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L)35(eiomyosar)-32(coma )]TJ 0.008 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he esopha)-17(gus. )]TJ /T1_1 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Thoracic and Cardiov)16.1(ascular Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1978;75\(5\):740\226746. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1442-2050.2003.00298.x)Tj 0 0 0 1 k /GS1 gs 0.333 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(W, S)-16(hao)]TJ /Span<>> BDC ( )Tj EMC (M, Hu)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he dia)-17(gnost)-32(ic v)-15(al)35(ue of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(o)]TJ 0 Tw (-)Tj 0.224 Tw -1.796 -1.25 Td [(scopic ul)56(tr)-33(asound for esopha)-17(geal subepi)-24(t)-13(hel)-30.9(ial lesions: A)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf 0.019 Tc 0.699 Tw T* (Medicine \(Baltimore\))Tj /T1_0 1 Tf [(. 2024;103\(46\):e40419. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.019 Tw (10.1097/)Tj 0 Tc 0 Tw T* (MD.0000000000040419)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ebi)Tj /Span<>> BDC ( )Tj EMC 1.601 0 Td [(M, )0.5(Sak)-16.9(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 5.423 0 Td [(K, )0.6(Inoue)]TJ /Span<>> BDC ( )Tj EMC 3.76 0 Td [(S, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.158 0 Td [(al. )0.6(Esopha)-17(geal )0.6(L)35(eiomyosar)-32(coma )]TJ 0.024 Tc 0.878 Tw -14.738 -1.25 Td [(Dia)-17.4(gnosed b)11.6(y End)-16.4(oscopic Ul)55.6(tr)-33.4(asound-guided F)-19.4(ine-needle)24( )]TJ 0 Tc 0.184 Tw T* [(Aspir)-33(a)15.1(t)-32(ion Biopsy and Cur)-23.9(ed wi)-24(t)-13(h Sur)-31.9(gical R)13(esec)-16(t)-32(ion. )]TJ /T1_1 1 Tf [(Inter)-14(n Med)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;58\(17\):2479\2262483. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.2169/inter)-15(nalmedic)-23.9(ine.2219-18)]TJ 0 0 0 1 k /GS1 gs 0.171 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mekr)-33(as)]TJ /Span<>> BDC ( )Tj EMC [(A, Kr)-24(enn)]TJ /Span<>> BDC ( )Tj EMC [(V, P)30(er)-24(r)-32.9(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gastr)-31.9(ointest)-32(inal schw)-12(an)]TJ 0 Tw (-)Tj 0.225 Tw -1.796 -1.25 Td (nomas: a)Tj /Span<>> BDC ( )Tj EMC [(r)-32.9(ar)-24(e but im)10(por)-21.9(t)15(ant dif)-56(fer)-23.9(ent)-32(ial dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC (mesenchy)Tj 0 Tw 27.286 0 Td (-)Tj 0.342 Tw -27.286 -1.25 Td [(mal tumor)-9.9(s of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-32(ointest)-31.9(inal tr)-33(a)-17(c)-16(t. )]TJ /T1_1 1 Tf 16.678 0 Td (BMC Surg)Tj /T1_0 1 Tf (. 2018;18\(1\):47. )Tj 0 Tw 12.377 73.75 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s12893-018-0379-2)Tj 0 0 0 1 k /GS1 gs 0.018 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hu)Tj /Span<>> BDC ( )Tj EMC [(J, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC (X, Ge)Tj /Span<>> BDC ( )Tj EMC [(N, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-32.9(asound and end)-15.9(o)]TJ 0 Tw (-)Tj 0.019 Tw -1.796 -1.25 Td [(scopic r)-24(esec)-16(t)-31.9(ion for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-37(ic schw)-12(annoma. )]TJ /T1_1 1 Tf 0 Tw (Medicine)Tj /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2017;96\(25\):e7175. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MD.0000000000007175)Tj 0 0 0 1 k /GS1 gs 0.312 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC (SH, Kim)Tj /Span<>> BDC ( )Tj EMC [(GH, P)40(ar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(DY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-15.9(osono)-16(gr)-33(aphic f)-28(indings )]TJ 0.095 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.143 0 Td [(gastr)-37(ic )0.5(ec)-16(t)17.1(opic )0.5(p)32(ancr)-24(eas: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 11.452 0 Td [(single )0.5(center )0.5(e)-18(xper)-36.9(ience. )]TJ /T1_1 1 Tf 10.667 0 Td [(J )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 1.889 0 Td (Gastro )Tj 0.02 Tc 0.718 Tw -25.151 -1.25 Td (and Hepatol)Tj /T1_0 1 Tf [(. 2011;26\(9\):1441\2261446. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.02 Tw (10.1111/j.1440-)Tj 0 Tc 0 Tw T* (1746.2011.06764.x)Tj 0 0 0 1 k /GS1 gs 0.006 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(ong)]TJ /Span<>> BDC ( )Tj EMC 2.273 0 Td [(L, )0.5(Kid)42.1(a)]TJ /Span<>> BDC ( )Tj EMC 2.824 0 Td [(M, )0.6(Y)49.9(amauchi)]TJ /Span<>> BDC ( )Tj EMC 5.16 0 Td [(H, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.104 0 Td [(al. )0.6(F)20(a)-17(c)-16(t)17(or)-10(s )0.5(af)-56(fec)-15.9(t)-32(ing )0.5(t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC 9.962 0 Td [(dia)-17(gnos)]TJ 0 Tw (-)Tj -0.021 Tw -24.119 -1.25 Td [(t)-32(ic a)-17(ccur)-32.9(a)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-33(asono)-16(gr)-32.9(aphy)]TJ /Span<>> BDC (-)Tj EMC [(guided f)-28(ine)]TJ /Span<>> BDC (-)Tj EMC (needle aspi)Tj 0 Tw (-)Tj 0.107 Tw T* [(r)-33(a)15(t)-32(ion \(EUS)]TJ /Span<>> BDC (-)Tj EMC [(FN)13.1(A\) for upper gastr)-32(ointest)-31.9(inal submucosal or e)-18(xtr)-32.9(al)34.9(u)]TJ 0 Tw (-)Tj 0.066 Tw T* [(minal sol)-31(id mass lesions. )]TJ /T1_1 1 Tf [(Dig)12.1(estiv)13(e Endoscop)12(y)]TJ /T1_0 1 Tf (. 2012;24\(5\):358\226363. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1443-1661.2012.01243.x)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.374 Tw -1.847 -1.25 Td (45.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(MK. End)-16(oscopic Ul)56(tr)-33(asound in Gastr)-31.9(oenter)-32(op)32(ancr)-24(ea)15(t)-32(ic)10( )]TJ 0 Tc -0.068 Tw -1.836 -1.25 Td [(Neur)-32(oend)-15.9(o)-16(cr)-37(ine T)60(umor)-10(s. )]TJ /T1_1 1 Tf [(Gut Liv)13(er)]TJ /T1_0 1 Tf [(. 2012;6\(4\):405\226410. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5009/)Tj T* (gnl.2012.6.4.405)Tj 0 0 0 1 k /GS1 gs -0.049 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(McL)35(ean)]TJ /Span<>> BDC ( )Tj EMC [(AM, F)20(air)-32(cl)30.1(ough)]TJ /Span<>> BDC ( )Tj EMC [(PD. End)-16(oscopic ul)56.1(tr)-33(asound in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(l)30.1(o)-16(cal)-31(isa)]TJ 0 Tw (-)Tj 0.008 Tw -1.796 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ancr)-24(ea)15(t)-32(ic isle)-12(t cell tumour)-9.9(s. )]TJ /T1_1 1 Tf [(Best Practice & R)21(esearch Clinical )]TJ 0.195 Tw T* [(Endocr)-36.9(inology & Metabolis)33.1(m)]TJ /T1_0 1 Tf [(. 2005;19\(2\):177\226193. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (beem.2004.11.012)Tj 0 0 0 1 k /GS1 gs 0.272 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(int)17.1(o-P)40(ais)]TJ /Span<>> BDC ( )Tj EMC [(T, F)10(er)-15(nandes)]TJ /Span<>> BDC ( )Tj EMC [(S, P)35(r)-32(oen\347a)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(L)-31.9(ar)-32(ge Gastr)-37(ic )]TJ 0.026 Tw -1.796 -1.25 Td [(Infl)-15.9(amma)15(t)17(or)-24(y F)-19(ibr)-32(oid P)10(ol)35(yp. )]TJ /T1_1 1 Tf [(GE P)15(or)-39.9(t J Gastroenterol)]TJ /T1_0 1 Tf (. 2015;22\(2\):61\226)Tj 0.023 Tw T* [(64. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jpge.2014.07.006)Tj 0 0 0 1 k /GS1 gs 0.321 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\207\036\035\034\n\036\030)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \025\024\f\021\t\030\022\024)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \215\030\017\r\024\030\024\021\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\205., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.238 Tw -1.796 -1.25 Td (\202\002\036\030\030\026\027\021\027\026\016 \023\024\007\032\036\035\031\ \007\024\004\027\026\016 \032\036\035\036\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\036\005. )Tj /T1_1 1 Tf (\211\031\033\032\031\024\013 \030\027\023\024\n\031\235 )Tj 0 Tw T* (\030\022\027\023\031\f\031\b\022\022)Tj /T1_0 1 Tf 0.069 Tw [(. 2013;11\(3\):49\22654. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.20953/1727-5784-2013-3-)Tj T* (49-54)Tj 0 0 0 1 k /GS1 gs -0.002 Tw ( / Belmer)Tj /Span<>> BDC ( )Tj EMC [(S)-13(V, K)25(ost)-10(yr)-23.9(ko)]TJ /Span<>> BDC ( )Tj EMC [(EV, P)35(r)-36.9(i)-16(vor)-32(o)17(tsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(VF, L)35(uppov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(NE. A)-14(ber)-23.9(r)-33(ant )]TJ 0.01 Tw T* [(p)32(ancr)-24(eas )0.6(in )0.5(childr)-23.9(en. )]TJ /T1_1 1 Tf 8.687 0 Td [(Issues )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 3.672 0 Td [(pediatr)-36.9(ic )0.5(dietetics.)]TJ /T1_0 1 Tf [( )0.6(2013;11\(3\):49\22654. )]TJ 0.023 Tw -12.359 -1.25 Td [(\(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.20953/1727-5784-2013-3-49-54)Tj 0 0 0 1 k /GS1 gs 0.272 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)30(t)-30(t)-32(well)]TJ /Span<>> BDC ( )Tj EMC (A, Sams)Tj /Span<>> BDC ( )Tj EMC [(S, F)10(uk)-17(ami)]TJ /Span<>> BDC ( )Tj EMC [(N. Dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(ec)-16(t)17(opic p)32(ancr)-24(eas )]TJ 0.005 Tc 0.349 Tw -1.796 -1.25 Td [(b)12.2(y end)-15.8(oscopic ul)56.2(tr)-32.7(asound wi)-23.7(t)-12.8(h f)-27.8(ine-needle aspir)-32.8(a)15.3(t)-31.8(ion. )]TJ /T1_1 1 Tf [(W)29.2(orld J)5( )]TJ 0 Tc 0 Tw T* (Gastroenterol)Tj /T1_0 1 Tf -0.054 Tw [(. 2015;21\(8\):2367\2262373. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v21.i8.2367)Tj 0 0 0 1 k /GS1 gs 0.319 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ar)-33(a)-17(ca)]TJ /Span<>> BDC ( )Tj EMC [(C, T)60(ur)-15(ner)]TJ /Span<>> BDC ( )Tj EMC (BG, Cizginer)Tj /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-24.9(ccur)-33(a)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC (EUS in )Tj 0.015 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ev)-15(al)35(ua)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(s)26(mall gastr)-37(ic subepi)-23.9(t)-13(hel)-31(ial lesions. )]TJ /T1_1 1 Tf 0 Tw 21.416 0 Td (Gastrointestinal )Tj -21.416 -1.25 Td [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.023 Tw [(. 2010;71\(4\):722\226727. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2009.10.019)Tj 0 0 0 1 k /GS1 gs -0.112 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(ev)-16(ia)]TJ /Span<>> BDC ( )Tj EMC [(RA, S)-16(hah)]TJ /Span<>> BDC ( )Tj EMC [(R, Mand)42(al)-31(ia)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Esopha)-16.9(geal G)20(r)-32.9(anul)-16(ar Cell T)60(umor: )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td (An)Tj /Span<>> BDC ( )Tj EMC [(U)13.2(ncommon Cause of)]TJ /Span<>> BDC ( )Tj EMC [(Dy)-12.8(spha)-16.7(gia. )]TJ /T1_1 1 Tf -0.001 Tw (Cureus)Tj /T1_0 1 Tf 0.349 Tw [(. 2023;15\(7\):e41846.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.7759/cur)-23.9(eus.41846)]TJ 0 0 0 1 k /GS1 gs -0.001 Tw -1.847 -1.25 Td (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-20(yu)]TJ /Span<>> BDC ( )Tj EMC (DG, Kim)Tj /Span<>> BDC ( )Tj EMC (SJ, Choi)Tj /Span<>> BDC ( )Tj EMC [(CW, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Combina)15(t)-32(ion convent)-32(ional end)-16(os)]TJ 0 Tw (-)Tj 0.077 Tw -1.796 -1.25 Td [(copy and end)-16(oscopic ul)56.1(tr)-33(asound can dif)-56(fer)-23.9(ent)-32(ia)15(te be)-12(t)-32(ween esopha)]TJ 0 Tw (-)Tj 0.251 Tw T* [(geal gr)-33(anul)-15.9(ar cell tumor)-10(s and leiomyomas. )]TJ /T1_1 1 Tf (Medicine \(Baltimore\))Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2022;101\(45\):e31435. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MD.0000000000031435)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.472 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (\212\r\024\030\026\022\024\r\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\230.\200., \202\030\017\220\035\034)Tj /Span<>> BDC ( )Tj EMC (\207.\204., \210\030\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0 Tc 0.212 Tw -1.847 -1.25 Td [(\003\036\030\027\017\f\021\024-\022\035\036\021\024\004\027\026\016 )0.7(\024\023\031\b\024\035\034 )0.6(\007\t\b\026\021\036\035\034\027\t\b )0.7(\023\031\021\036\005. )]TJ /T1_1 1 Tf 21.363 0 Td [(\003\032\200\022\021 )0.6(\033\020\023\031\f\031)]TJ 0 Tw (-)Tj -21.363 -1.25 Td (\b\022\022)Tj /T1_0 1 Tf 0.045 Tw [(. 75\(3\):34\22639. / Dvor)-33(akovsk)-16.9(aia)]TJ /Span<>> BDC ( )Tj EMC [(I.V., Ar)-37(i\351l\241 B.M., Or)-29.9(l)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.076 Tw T* [(Air)-38(w)-11.9(a)15(y gr)-33(anul)-16(ar cell tumor. )]TJ /T1_1 1 Tf [(R)22(ussian Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Archiv)13(e of)]TJ /Span<>> BDC ( )Tj EMC [(P)18(athology.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2013;75\(3\):34)Tj /Span<>> BDC (-)Tj EMC (39. \(In Russ.\))Tj 0.013 Tc 0.485 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.849 0 Td [(L)-32.2(iu)]TJ /Span<>> BDC ( )Tj EMC [(R, A)14.8(dler)]TJ /Span<>> BDC ( )Tj EMC [(DG. Dupl)-31.2(ica)14.8(t)-32.2(ion cy)-13.2(sts: Dia)-17.2(gnosis, mana)-17.2(ge)]TJ 0 Tc 0 Tw (-)Tj 0.231 Tw -1.849 -1.25 Td [(ment, and t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-32.9(asound. )]TJ /T1_1 1 Tf (Endosc Ultrasound)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2014;3\(3\):152\226160. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4103/2303-9027.138783)Tj 0 0 0 1 k /GS1 gs 0.037 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(El)30(oubeidi)]TJ /Span<>> BDC ( )Tj EMC (MA, Cohn)Tj /Span<>> BDC ( )Tj EMC [(M, Cer)-24(fol)-30.9(io)]TJ /Span<>> BDC ( )Tj EMC [(RJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic ul)56(tr)-32.9(asound-)]TJ -0.023 Tw -1.796 -1.25 Td [(guided f)-28(ine-needle aspir)-33(a)15(t)-32(ion in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(for)-24(egut dupl)-31(ica)15(t)-32(ion )]TJ -0.008 Tw T* [(cy)-13(sts: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(v)-15(al)35.1(ue of)]TJ /Span<>> BDC ( )Tj EMC [(demonstr)-32.9(a)15(t)-32(ing de)-12(t)15(a)-17(ched c)-24(il)-31(iar)-23.9(y tuf)-28(ts in cy)-13(st fl)35(uid. )]TJ /T1_1 1 Tf 0 Tw T* (Cancer)Tj /T1_0 1 Tf 0.023 Tw [(. 2004;102\(4\):253\226258. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cncr.20369)Tj 0 0 0 1 k /GS1 gs 0.258 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ahi)]TJ /Span<>> BDC ( )Tj EMC (JE, Safdie)Tj /Span<>> BDC ( )Tj EMC [(FM. 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Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.124 Tw 10 0 0 10 42.5197 724.8299 Tm (\222\021\026\030\004\036\027\022\024\r \212\036\027\017\f \212\n\017\021\ \030\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw 0 -1.218 TD (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0003-3726-8246)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Mikhail S. Bur)-23.9(d)17(yukov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4690-9335)Tj 0 -1.218 TD [(Nair)-33(a A. Ha)15.1(yr)-33(ape)-11.9(t)-10(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7295-8037)Tj 0 -1.218 TD [(Ild)42(ar R. V)25.1(al)-31(iul)-31(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-6110-8941)Tj T* [(Ale)-18(x)12(e)-10.9(y A. Gvozdev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3096-2070)Tj T* [(G)20(r)-37(igor)-23.9(y A. K)25(or)-32(olev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5730-3684)Tj T* [(Ox)-11(ana V. P)40.1(akl)-31(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6373-1888)Tj 23.244 12.178 Td [(V)25(aler)-37(i)-16(ia I. R)-19.9(y)22(ab)16(tsev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3174-7695)Tj T* [(Na)15(t)15(al)-31(ia V. A)-24.9(ge)-11(yk)-15.9(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8726-0929)Tj T* [(Ev)-21(genia V. Gusev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0009-3782-8366)Tj T* [(Il)-31(ia I. Iv)-14.9(anov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0002-8492-2856)Tj T* [(Ir)-37(ina Y)35.1(u. K)25(or)-24(zhev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-5984-5660)Tj T* [(Mak)-10(sim M. L)35.1(okhma)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8305-7592)Tj 0 -1.218 TD [(T)40(a)15(t)-32(iana V. 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A)Tj /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-23.9(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(sym)10(p)]TJ 0 Tw (-)Tj 0.004 Tw -1.296 -1.25 Td [(t)17(oma)15(t)-32(ic s)26(mall bo)-14(wel l)-30.9(ipomas of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he jejunum and ileum. )]TJ /T1_4 1 Tf (Ann Med Surg )Tj 0 Tw T* (\(Lond\))Tj /T1_1 1 Tf 0.023 Tw [(. 2020;58:52\22667. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.amsu.2020.08.028)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.349 Tw T* [(5)0.5(.)]TJ /Span<>> BDC 0.809 0 Td ( )Tj EMC 0.506 0 Td [(B)0.5(l)-15.4(a)0.5(n)0.5(c)0.5(h)0.6(e)-11.5(t)]TJ /Span<>> BDC 3.642 0 Td ( )Tj EMC [(M)0.6(C)0.5(,)0.5( A)0.5(r)-14.5(n)0.6(a)0.5(l)]TJ /Span<>> BDC 4.674 0 Td ( )Tj EMC [(E)0.6(,)0.5( P)40.5(a)0.5(p)32.5(a)0.6(r)-23.5(e)0.5(l)]TJ /Span<>> BDC 4.836 0 Td ( )Tj EMC [(P)0.6(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 2.731 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( O)0.5(b)0.5(s)0.6(t)0.5(r)-21.5(u)0.6(c)-15.5(t)-31.5(i)-15.4(v)0.5(e)0.5( d)0.5(u)0.5(o)0.6(d)0.5(e)]TJ 0 Tc 0 Tw 10.088 0 Td (-)Tj 0.013 Tc 0.485 Tw -27.286 -1.25 Td [(nal l)-31.2(ipoma successfull)34.8(y tr)-24.2(ea)14.7(ted b)11.8(y end)-16.2(oscopic pol)34.8(ypec)-16.2(t)16.8(omy.)13( )]TJ /T1_4 1 Tf 0.01 Tc 0.371 Tw T* [(Gastrointestinal Endoscop)12.1(y)]TJ /T1_1 1 Tf [(. 2003;58\(6\):938\226939. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1016/)Tj 0 Tc 0 Tw T* (S0016-5107\(03\)02232-6)Tj 0 0 0 1 k /GS1 gs 0.333 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(a)15(t)17(os)]TJ /Span<>> BDC ( )Tj EMC [(W, K)-16(a)10(wczyk-Kr)-21.9(upk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(A, S)15(tr)-24(zel)16(czyk)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Benign and )Tj 0.012 Tc 0.438 Tw -1.296 -1.25 Td [(non-neopl)-15.8(ast)-31.9(ic tumour)-9.9(s of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.8(he duodenum. )]TJ /T1_4 1 Tf [(Pr)-15.8(z Gastroenterol)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2019;14\(4\):233\226241. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5114/pg.2019.90250)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.451 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.333 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(JH, Y)39.8(o)-16.2(on)]TJ /Span<>> BDC ( )Tj EMC (HH, Jeong)Tj /Span<>> BDC ( )Tj EMC [(SH, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Spont)14.8(aneous peeled)12( )]TJ 0.015 Tc 0.531 Tw -1.333 -1.25 Td [(i)0.5(l)0.5(e)0.5(a)0.5(l)0.5( )0.5(g)0.5(i)0.5(a)0.5(nt)0.6( l)-30.5(i)0.5(p)0.5(o)0.5(m)0.5(a)0.5( )0.5(c)0.5(a)0.5(u)0.5(s)0.5(e)0.5(d)0.5( b)12.5(y)0.5( )0.5(l)30.5(o)-13.5(w)0.5(e)0.5(r)0.5( g)0.5(a)0.5(s)0.5(t)0.5(r)-31.5(o)0.5(i)0.5(n)0.5(t)0.5(e)0.5(s)0.5(t)-31.4(i)0.5(na)0.5(l)0.6( b)0.5(l)0.5(e)0.5(e)0.5(d)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj 0.013 Tc -0.013 Tw -27.286 -1.25 Td [(i)0.5(n)0.5(g)0.5(.)0.5( )]TJ /T1_4 1 Tf 0.461 Tw 2.35 0 Td [(M)0.5(e)0.5(d)0.5(i)0.5(c)0.5(i)0.5(n)0.5(e)0.5( )0.6(\()0.5(B)0.5(a)0.5(l)0.5(t)0.5(i)0.5(m)0.5(o)0.5(r)0.5(e)0.5(\))]TJ /T1_1 1 Tf 9.057 0 Td [(.)0.5( )0.5(2)0.5(0)0.5(1)0.5(7)0.5(;)0.5(9)0.5(6)0.5(\()0.5(5)0.5(1)0.5(\))0.5(:)0.5(e)0.5(9)0.5(2)0.5(5)0.5(3)0.5(.)0.5( )0.5(d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 11.697 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw 0.706 0 Td [(1)0.5(0)0.5(.)0.5(1)0.5(0)0.5(9)0.5(7)0.5(/)]TJ 0 Tc 0 Tw -23.811 -1.25 Td (MD.0000000000009253)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.349 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.308 0 Td [(W)12.1(ang)]TJ /Span<>> BDC ( )Tj EMC (CY, Hsu)Tj /Span<>> BDC ( )Tj EMC [(HS, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(Y)32.1(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Intr)-32.9(amur)-32.9(al L)-31.9(ipoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he)4( )]TJ 0 Tc 0 Tw -1.308 -1.25 Td [(Esopha)-17(gus. )]TJ /T1_4 1 Tf 0.178 Tw 4.987 0 Td (J Chin Med Assoc)Tj /T1_1 1 Tf [(. 2005;68\(5\):240\226243. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj -4.987 -1.25 Td (S1726-4901\(09\)70216-3)Tj 0 0 0 1 k /GS1 gs 0.163 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)20(aul)-32(x)]TJ /Span<>> BDC ( )Tj EMC [(AL, K)25(o)17(t)-12.9(har)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(S, A)-25(cost)15(a)]TJ /Span<>> BDC ( )Tj EMC [(RD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopy in )]TJ 0.276 Tw -1.296 -1.25 Td [(subepi)-24(t)-12.9(hel)-31(ial )0.6(lesions )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.463 0 Td [(t)-13(he )0.6(GI )0.5(tr)-33(a)-16.9(c)-16(t. )]TJ /T1_4 1 Tf 6.068 0 Td [(Gastrointestinal )0.7(Endoscop)12(y)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw -16.532 -1.25 Td [(2017;85\(6\):1117\2261132. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2017.02.022)Tj 0 0 0 1 k /GS1 gs 0.049 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(er)-16(mos)]TJ /Span<>> BDC ( )Tj EMC [(S, R)13(esl)-16(an)]TJ /Span<>> BDC ( )Tj EMC [(O, Al)25(qabandi)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Giant gastr)-36.9(ic l)-31(ipoma p)25(r)-24(e)]TJ 0 Tw (-)Tj 0.085 Tw -1.796 -1.25 Td [(sent)-32(ing as GI bleed: Enuclea)15(t)-32(ion or R)13(esec)-16(t)-31.9(ion? )]TJ /T1_4 1 Tf [(Int J Surg Case R)20.9(ep)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;41:39\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijscr.2017.10.004)Tj 0 0 0 1 k /GS1 gs 0.026 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Amundson)Tj /Span<>> BDC ( )Tj EMC [(JR, S)15(tr)-32.9(aus)]TJ /Span<>> BDC ( )Tj EMC [(D, A)-23.9(zab)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Giant sym)10(pt)17(oma)15(t)-31.9(ic gastr)-37(ic )]TJ 0.192 Tw -1.796 -1.25 Td [(l)-31(ipoma: A)]TJ /Span<>> BDC ( )Tj EMC [(case r)-24(epor)-22(t and l)-31(i)-24(ter)-32.9(a)15(tur)-24(e r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Int J Surg Case R)21(ep)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2018;51:313\226317. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijscr.2018.08.061)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.615 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.864 0 Td (\025\026\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \204\026\021\r\017\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\203.\202., \206\026\035\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\003.\200., \017)Tj /Span<>> BDC ( )Tj EMC 23.14 0 Td [(\f\024\026\r\021.)17( )]TJ 0 Tc 0.065 Tw -25.003 -1.25 Td (\233\027\007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\ \036\027\017\036 \017\027\021\036\f\021\017\027\026\035\034\027\024\005 \ \035\017\023\024\n\t \002\024\035\034\001\017\b \030\026)Tj 0 Tw (-)Tj T* (\n\036\030\024\r. )Tj /T1_4 1 Tf 0.301 Tw 3.344 0 Td (\220\031\n\020\016\020\023\027\f\017\025\020\t \b\020\024\023\032\031\204\ \025\023\027\032\031\f\031\b\022\t)Tj /T1_1 1 Tf (. 2018;7\(2\):70\22679. / )Tj 0.264 Tw -3.344 -1.25 Td [(K)-16(ashin)]TJ /Span<>> BDC ( )Tj EMC 3.199 0 Td [(S.V., )0.6(Ma)15(t)-24(v)-16(ienko)]TJ /Span<>> BDC ( )Tj EMC 6.896 0 Td [(N.A., )0.6(Galkov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC 6.041 0 Td [(Z.V., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.545 0 Td [(al. )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.411 0 Td [(end)-16(oscopic )]TJ -0.035 Tw -23.092 -1.25 Td [(r)-24(emov)-14.9(al of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(l)-16(ar)-32(ge-size intest)-32(inal l)-31(ipoma. )]TJ /T1_4 1 Tf [(R)22(ussian Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (Evidence-)Tj 0.018 Tw T* (Based Gastroenterology. )Tj /T1_1 1 Tf (2018;7\(2\):70)Tj /Span<>> BDC (-)Tj EMC [(79. \(In Russ.\). d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17116/)Tj T* [(d)-16(okgastr)-31.9(o20187270)]TJ 0 0 0 1 k /GS1 gs 0.189 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(er)-24(r)-33(ar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC 3.085 0 Td [(D, )0.5(Ber)-15(nar)-23.9(di)]TJ /Span<>> BDC ( )Tj EMC [(D, )0.5(S)-16(iboni)]TJ /Span<>> BDC ( )Tj EMC 9.167 0 Td [(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.322 0 Td [(al. )0.5(Esopha)-17(geal )0.5(L)-31.9(ipoma )0.5(and )]TJ 0.143 Tw -16.37 -1.25 Td [(L)-32(iposar)-32(coma: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew. )]TJ /T1_4 1 Tf [(W)29(orld J Surg)]TJ /T1_1 1 Tf (. 2021;45\(1\):225\226)Tj 0.023 Tw T* [(234. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00268-020-05789-4)Tj 0 0 0 1 k /GS1 gs 0.131 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(S, K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(A, Da)15(y)22(al)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gastr)-36.9(ic l)-31(ipoma: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(ar)-24(e cause )]TJ 0.09 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(massi)-15.9(ve haema)15(temesis. )]TJ /T1_4 1 Tf [(Ann R Coll Surg Eng)13(l)]TJ /T1_1 1 Tf (. 2021;103\(6\):e196\226)Tj 0.023 Tw T* [(e198. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1308/r)-32(csann.2020.7094)]TJ 0 0 0 1 k /GS1 gs 0.157 Tw 29.055 58.75 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(o)-14(wler)]TJ /Span<>> BDC ( )Tj EMC [(DL, Whi)-24(te)]TJ /Span<>> BDC ( )Tj EMC [(SA. L)-32(ap)32(ar)-32(oscopic R)13(esec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC (Submucosal )Tj 0.055 Tw -1.796 -1.25 Td [(Gastr)-36.9(ic L)-32(ipoma: A)]TJ /Span<>> BDC ( )Tj EMC [(Case R)13(epor)-22(t. )]TJ /T1_4 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Laparoendoscopic Surg)12(er)-43(y)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1991;1\(5\):303\226306. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1089/lps.1991.1.303)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.468 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td [(K)-15.7(ad)42.3(aba)]TJ /Span<>> BDC ( )Tj EMC [(R, Bo)-13.7(wer)-9.7(s)]TJ /Span<>> BDC ( )Tj EMC [(KA, W)-15.6(ijesur)-36.7(iy)22.2(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC (al. An)Tj /Span<>> BDC ( )Tj EMC [(U)13.3(nusual)13( )]TJ 0 Tc 0.341 Tw -1.847 -1.25 Td (Cause of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-32(ointest)-32(inal Bleeding: Duodenal L)-32(ipoma. )]TJ /T1_4 1 Tf [(Case R)21(ep )]TJ 0 Tw T* (Gastroenterol)Tj /T1_1 1 Tf 0.023 Tw [(. 2011;5\(1\):183\226188. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000327219)Tj 0 0 0 1 k /GS1 gs 0.23 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M\241r)-33(abe)-12(t S, Jar)-24(r)-32.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(MS, Akk)-16.9(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(onic intussuscept)-32(ion )]TJ 0.156 Tw -1.796 -1.25 Td [(caused b)12(y a)]TJ /Span<>> BDC ( )Tj EMC [(sigmoid)42(al l)-31(ipoma: A)]TJ /Span<>> BDC ( )Tj EMC [(case r)-24(epor)-22(t. )]TJ /T1_4 1 Tf [(Int J Surg Case R)21(ep)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2018;50:1\2264. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijscr.2018.06.009)Tj 0 0 0 1 k /GS1 gs -0.002 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(int)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(J, Castel)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(J, M\343o de F)10(er)-24(r)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(S. Jejunal L)-32(ipoma, an)]TJ /Span<>> BDC ( )Tj EMC [(U)13(ncommon )]TJ 0.012 Tc 0.455 Tw -1.796 -1.25 Td (Cause of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-32.3(ointest)-32.4(inal Bleeding. )]TJ /T1_4 1 Tf [(GE P)14.7(or)-40.4(t J Gastroenterol)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2018;25\(6\):337\226339. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000486560)Tj 0 0 0 1 k /GS1 gs 0.311 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ingason)Tj /Span<>> BDC ( )Tj EMC [(A)44(B, T)47.1(heod)-16(or)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(A, A)-25(gustsson)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Giant gastr)-37(ic )]TJ 0.003 Tc 0.35 Tw -1.796 -1.25 Td [(l)-31(ipoma )0.6(successfull)35(y )0.5(r)-24(emoved )0.5(b)12(y )0.6(end)-16(oscopic )0.5(submucosal )0.6(dissec)]TJ 0 Tc 0 Tw (-)Tj 0.007 Tc 0.349 Tw T* [(t)-31.7(ion: case r)-23.6(epor)-21.6(t and sy)-12.6(stema)15.3(t)-31.6(ic r)-23.6(ev)-15.6(iew. )]TJ /T1_4 1 Tf [(Scandinavian Jour)-13.7(nal)7( )]TJ 0 Tc 0.111 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (Gastroenterology)Tj /T1_1 1 Tf [(. 2018;53\(8\):1018\2261024. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/0036552)Tj T* (1.2018.1495259)Tj 0 0 0 1 k /GS1 gs 0.047 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Menegon )0.5(T)40(assell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(F, )0.5(U)15(r)-23.9(r)-33(ar)-32(o)]TJ /Span<>> BDC ( )Tj EMC 10.901 0 Td [(F, )0.5(S)-24(c)-24(iaud)-15.9(one)]TJ /Span<>> BDC ( )Tj EMC [(G, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Col)30.1(onic L)-31.9(ipoma )]TJ 0.023 Tw -12.697 -1.25 Td [(Causing )0.6(Bo)-14(wel )0.6(Intussuscept)-32(ion: )0.6(An)]TJ /Span<>> BDC ( )Tj EMC 14.478 0 Td [(U)13(p-t)17(o-Da)15(te )0.6(Sy)-13(stema)15(t)-32(ic )0.6(R)13(ev)-16(iew. )]TJ /T1_4 1 Tf 0 Tw 12.722 0 Td (J )Tj 0.023 Tw -27.2 -1.25 Td (Clin Med)Tj /T1_1 1 Tf [(. 2021;10\(21\):5149. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm10215149)Tj 0 0 0 1 k /GS1 gs 0.139 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)35(u)]TJ /Span<>> BDC ( )Tj EMC (HG, Ding)Tj /Span<>> BDC ( )Tj EMC [(YM, T)40(an)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(safe and ef)-56(f)-28(ic)-24(ient str)-32.9(a)15(teg)16(y for )]TJ 0.05 Tw -1.796 -1.25 Td [(end)-16(oscopic r)-24(esec)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ar)-32(ge, gastr)-32(ointest)-31.9(inal l)-31(ipoma. )]TJ /T1_4 1 Tf (Surg Endosc)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2007;21\(2\):265\226269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00464-006-0059-7)Tj 0 0 0 1 k /GS1 gs 0.251 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(iech)]TJ /Span<>> BDC ( )Tj EMC [(T, W)12(al)16(ch)]TJ /Span<>> BDC ( )Tj EMC [(A, W)22(er)-15(ner)]TJ /Span<>> BDC ( )Tj EMC [(M. Hist)17.1(op)32(a)15(t)-13(hol)30(o)-16(gical Cl)-16(assif)-28(ica)15(t)-32(ion )]TJ 0.012 Tc 0.424 Tw -1.796 -1.25 Td [(o)0.5(f)]TJ /Span<>> BDC 0.838 0 Td ( )Tj EMC [(N)-13.5(o)0.6(n)0.5(n)0.5(e)0.6(o)0.5(p)0.5(l)-15.4(a)0.5(s)0.5(t)-31.4(i)0.5(c)0.5( a)0.6(n)0.5(d)0.5( N)0.5(e)0.6(o)0.5(p)0.5(l)-15.4(a)0.5(s)0.6(t)-31.5(i)0.5(c)0.6( G)0.5(a)0.5(s)0.6(t)0.5(r)-31.5(o)0.6(i)0.5(n)0.5(t)0.6(e)0.5(s)0.6(t)-31.5(i)0.5(n)0.6(a)0.5(l)0.5( S)0.5(u)0.6(b)0.5(m)0.6(u)0.5(c)0.5(o)0.5(s)0.6(a)0.5(l)12( )]TJ 0.009 Tc -0.009 Tw -0.838 -1.25 Td [(L)34.6(esions. )]TJ /T1_4 1 Tf 3.917 0 Td [(Endoscop)11.6(y)]TJ /T1_1 1 Tf 0.352 Tw [(. 2005;37\(7\):630\226634. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw (10.1055/s-2005-)Tj 0 Tc 0 Tw -3.917 -1.25 Td (870127)Tj 0 0 0 1 k /GS1 gs 0.218 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\264\036\030\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\214., \207\t\f\021\030\024\r\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \212\024\035\020\026\001\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\206.\204., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.073 Tw -1.796 -1.25 Td (\233\027\007\024\f\024\027\024\020\030\026\235\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \027\036\220\023\017\021\036\035\ \017\026\035\034\027\t\b \024\023\031\b\024\035\036\005 \023\017\013\036\ )Tj 0 Tw (-)Tj 0.108 Tw T* (\r\024\007\026, \032\036\035\031\007\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\017. )Tj /T1_4 1 Tf 0 Tw (\230\n\024\033\027\032\022\026\027\025\023\020\f\017\025\020\t )Tj 0.025 Tc 0.891 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 1.672 0 Td [(\n\f\022\025\022\007\027\024\n\020\t )0.5(\b\020\024\023\032\031\204\025\023\027\032\031\f\031\b\022\t)]TJ /T1_1 1 Tf [(. )0.5(2010;\(10\):29\22631. /)25.1( )]TJ 0.012 Tc 0.441 Tw -1.672 -1.25 Td [(S)-15.9(hcher)-24(bakov)]TJ /Span<>> BDC ( )Tj EMC [(P.L., By)-12.9(str)-32(ovsk)-17(a)15.1(y)22.1(a)]TJ /Span<>> BDC ( )Tj EMC [(E.V., Dol)16.1(gashev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(G.M., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)12( )]TJ 0 Tc 0.321 Tw T* [(End)-16(osono)-15.9(gr)-33(aphy in dia)-17(gnost)-32(ics )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(non-epi)-24(t)-13(hel)-30.9(ial tumor)-10(s )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.001 Tw T* [(esopha)-17(gus, st)17(oma)-17(ch and duodenum. E)]TJ /T1_4 1 Tf [(xper)-37(imental and clinical g)12(astro)]TJ 0 Tw (-)Tj T* (enterology. )Tj /T1_1 1 Tf 0.023 Tw 4.707 0 Td (2010;\(10\):29\22631. \(In Russ.\).)Tj 0.146 Tw -4.707 -1.25 Td (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hw)-12(ang)]TJ /Span<>> BDC ( )Tj EMC [(JH, Saunder)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(MD, Rul)35.1(y)22(ak)]TJ /Span<>> BDC ( )Tj EMC [(SJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve stud)17.1(y )]TJ 0.319 Tw -1.796 -1.25 Td [(com)10(p)32(ar)-37(ing end)-16(oscopy and EUS in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (GI subepi)Tj 0 Tw (-)Tj 0.004 Tc 0.35 Tw T* [(t)-13.1(hel)-31.1(ial )0.5(masses. )]TJ /T1_4 1 Tf [(Gastrointestinal Endoscop)11.9(y)]TJ /T1_1 1 Tf [(. 2005;62\(2\):202\226208.)4( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/S0016-5107\(05\)01567-1)Tj 0 0 0 1 k /GS1 gs -0.078 Tw -1.847 -1.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(a)15(yl)30(or)]TJ /Span<>> BDC ( )Tj EMC [(AJ, S)15(tew)-12(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC (ET, Dodds)Tj /Span<>> BDC ( )Tj EMC [(W)31(J. Gastr)-32(ointest)-32(inal l)-30.9(ipomas: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(adio)]TJ 0 Tw (-)Tj 0.26 Tw -1.796 -1.25 Td [(l)30(o)-16(gic and p)32(a)15(t)-13(hol)30(o)-16(gic r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Amer)-36.9(ican Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(R)19(oentg)12(enology)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1990;155\(6\):1205\2261210. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2214/ajr.155.6.2122666)Tj 0 0 0 1 k /GS1 gs 0.013 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\203\036\004\017\023\026\005)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \210\030\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\224., \205\036\007\024\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\212. \233\211\222\002\031\022\026. \217\031\022\024\r\024\007\f\021\ \r\024 )Tj 0.241 Tw -1.796 -1.25 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \031\035\034\021\ \030\026\f\024\027\024\020\030\026\235\017\017. \204: \215\030\026\022\021\ \017\004\036\f\022\026\016 \n\036\007\017)Tj 0 Tw (-)Tj 0.216 Tw T* [(\006\017\027\026; 2013. / Nechip)32(a)15.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A.M., Or)-30(l)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.Y)35(u., F)10(ed)-16(or)-32(ov)]TJ /Span<>> BDC ( )Tj EMC [(E.D. EUSbo)-16(ok. )]TJ 0.086 Tw T* [(Guide t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-32.9(asono)-16(gr)-33(aphy. M: P)35(r)-33(a)-17(c)-16(t)-31.9(ical medic)-23.9(ine; 2013. )]TJ 0.023 Tw T* (\(In Russ.\))Tj 0.166 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ja)-17(cobson)]TJ /Span<>> BDC ( )Tj EMC [(BC, Bha)15(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(A, G)20(r)-24(eer)]TJ /Span<>> BDC ( )Tj EMC [(KB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)16(CG Cl)-31(inical Guidel)-30.9(ine: )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_5 1 Tf 25 0 0 25 505.5644 56.0378 Tm (179)Tj ET endstream endobj 87 0 obj <>>>/Subtype/Form>>stream 1 0.68 0 0.12 k /GS0 gs 42.52 54.638 453.543 1.375 re f 42.52 52.257 453.543 1.375 re f 42.52 755.476 453.543 1.375 re f endstream endobj 84 0 obj <> endobj 107 0 obj <> endobj 241 0 obj <> endobj 242 0 obj <> endobj 243 0 obj <>stream H\ˎ0D|E݋}Kb1 3@AB?[V"oέrv{5:\|N8}85|_p8ye۝٬~oãzj<~y8woӏW^|^i,i_r5i/x|sse!z̷~þ{˓Y=~l3~o^OaoѵHڪv Q/z9Aj9Fn8B^P_Qsu[Co9&B߀ǐߠ!s j[<ːߠ!iohxboѯ!չ[uO~~:Zj@mF6Q6Ԩo.+j`nѻ#3tqq:u:2;0;2;0;2Zrdv`v-5|2 f ބ !AȠkX `2 !(=x(PCB =xX?~`X?~`Oೂ>O?O?O?D?~!JrdE4XDcE4XDcRkbL ]"R D4(PR D(ЩaI%d*SR (i.~k 4׍Ԕ@G!n"jJ f5 8 ?^vSQ~А_7XS&iJ÷X-] E5uc/x}kZ(8dz8a0z멊38  Z*ɮ endstream endobj 244 0 obj <>stream HdTkTSW>< \ 7xBVKEBa@Bj>Z[AMJP*"YhE ,,ƷEWq:c&x33?][{sPhELOT%Eϋ**Z7ugY -lgk^x%X+\6>!|c/f?s_iz}F$uZo~~~n:+j1٣/ޕ-k#,DYCcT?{)Oky7!,YVU*{kߺAkg+5r080#&vM}Tz9yyDi23ѻh`.fg8)t.2.\>l8,2nb Q|JF1l[kS4_tf>\+?BYH]Z^LhT'P}) Nx㘷ZMQum}d_ _ͬ~JRʐZOe>Q$teRG;aQg7nj&~GsH>Rì6KD,Fr8<q"AAo`y&)R3TK(D*3VقOIVRՠinnhhn4TW:,߾ KmL29UE6{D & ͽ~ڼ<)]PX.LքQA ɴgWhu`*_rRԾ62]L/[]/_'ʽZ9:D Վ_ҟ굖_ 2 fk͉ 6d9m&ԙӄO:"4w=-8s<UB'3w׉k#~h<]AxǸTb]Ǣ 5M)@:7],$ w0ԶY8v|颏򊴛DM뫋wMUNh.WR)RRqBݥ5~w-!>En)~~zώI߾G|eiӘ`]J 7#i>rQ7w;N5&h Emܷ_N܊` E"ݡ6}(^S_N=(D^E/0rǶJ9Aܩ&Cft5Z#I&ΊόyHϞ!r {=e۶h`z ^8~IRIr\Gk&x˱,Fr^W[oFgs*J3?xIhD#쌝%AMv- %e A>[hyRŁz_޻&*1##IlGGGGi ZAۧW] ҭ=o^*K 0 @Qok+%'&|m&},N]1׵CWvFȵ VEͲh,dƼᬘ@}oպch^ ۓ3\싲jj²ջzPU O局@ ⣃R((y#7^Hn+]Jι?Qk;;7;{};_Wtcx;|(o-WǕ=`bQr0sTg#)"'b:--3 3#lptΩ}hqN'Р- ] 'B8: TR@8㑟df)={m:RE2hyEnܕ˭{=.iБT:.LC7 }'3D8q`A#Pм+R#R^H$HxCrXqgQ#{bbADK@:EE+_Tr iD"o!1SiۢS KXuL;?t̍#[afF> [,F@:wYV,K HBC2Rłԑ͙['X',j*вH Rh$eXXslXti _E >6sx`NA$ B>89,"=褎1]k@|b\wXhP; M@vϪ;xlQ:<]xDٸB?)U% F{@M+vkKo?OiL铑!!䓯Rn o@`yuen5 PɢM N%Q;Z/-AiG'Ɖ6 :nAUx|365/MuaP r @[*·eWM4W&+>< O毉LeB_;@X3<[E o_Ө(BoZJGIӿ8.Lɐ酫9ȟ!E4{Z6z{R8~! j:OgRDKۡ&Ɣ]*\5GKM X0n?[~%Ymr N&\qu\h;^ 2q)98ӧ1_odzv/fL O+Pgg30N盳:m4z{R4y?sڶL]mMc^n'uroO ‡P:x$uc%jQMeN ??h!+S3cR(8)MZ`O<3x;+zsg2b tĶ=iL&j2E;[GiiRU颤mΔV+hn'B 8Zn엏_^j753C%^=n1c5: zƠI 9 LR)Ӥ)cuJ&@l{Hk=Ku/M|2*j;YHkr3=BTnO}mfQ"^'7+d?xYq LD79_ _zѨJ\TE8ls*|j6 c,P ߨdv.Ԁ?̛ P*"!ΛǥM^&ódhw9x/Uuޒh6K}{j(jۤT"l"2E@GAdU@@`! 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\221\r)-23.3(\032)-18.9(\030)-13.7(\005)-13.7(\n)-9.2(\031)-9.4(\021)]TJ /Span<>> BDC 19.037 0 Td ( )Tj EMC [(\215.)24.7(\205)-21(.)]TJ /T1_0 1 Tf 0 Tc 0.594 Tw -19.037 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.6(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf [( \003)19.4(\235)4.7(\032)3(\020)1.8(\033)4.5(\027\023)12.2(\t)10.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.04 Tw T* [(\211)11.7(\020)-5.2(\f)9.6(\022\r)23.8(\f)9.7(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.8(.)29.3(\206)93.9(.)7.8(, \216)109.3(\021)-0.8(\031)14.2(\016)2.2(\030)1.9(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, \206)28.6(\t)1.7(\240)8.1(\006)2.8(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)29.3(\002)28.8(.)7.8(, \202)15.6(\031)4.9(\032\031)10.1(\f)3.3(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\216)122(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.015 Tw T* [(\004)15.1(\020)4.8(\n)-21.2(\f)9.6(\022)7.2(\025)9.6(\020)]TJ /Span<>> BDC ( )Tj EMC 3.658 0 Td [(\217)27.6(.)28.5(\211)24.3(.)7.8(, )0.6(\216)98(\r)6.6(\024)9.8(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC 4.766 0 Td [(\036)22.8(.)28.5(\211)24.3(.)7.8(, )0.6(\002)20.8(\021)2.1(\020)4.3(\025)3.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 5.135 0 Td [(\002)28.8(.)29.3(\002)28.8(.)7.8(, )0.6(\035)11.7(\031)2.8(\200)-1.9(\026)6.9(\020)1.8(\023)4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 6.526 0 Td [(\215)19.4(.)20.1(\215)19.4(.)7.8(, )]TJ 0 Tw -20.085 -1.218 Td [(\001)14.6(\022)7.7(\n)9.8(\031)10.1(\f)9(\020)4.4(\235)19.4(\007\r)8.8(\n)]TJ /Span<>> BDC ( )Tj EMC [()65(.)28.5(\211)24.3(.)7.8(, \205)8.8(\022)6.7(\030)1.9(\031)4.9(\032)6.4(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)28.5(\211)24.3(.)7.8(, \205)4.6(\023)6.9(\020)1.8(\032)13.2(\007)3.8(\027)2.3(\025)10.7(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.5(.)-9.6(\220)1.4(.)]TJ /T1_0 1 Tf 0.002 Tc 0.282 Tw 0 -1.218 TD [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 0 Tc 0.284 Tw 7.978 0 Td [( \003)19.5(\235)4.7(\032)3(\020)1.8(\033)4.5(\027\023)12.2(\t)10.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)7.3(\003)-2.3(.)7.8(, \211)11.7(\020)-5.1(\f)9.6(\022\r)23.8(\f)9.6(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.8(.)29.3(\206)93.9(.)7.8(, )]TJ 1.162 Tw -7.978 -1.218 Td [(\216)109.3(\021)-0.8(\031)14.2(\016)2.2(\030)1.9(\027)6.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, )0.5(\206)28.6(\t)1.7(\240)8.1(\006)2.7(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC 12.454 0 Td [(\211)24.3(.)29.3(\002)28.8(.)7.8(, )0.5(\202)15.6(\031)4.9(\032\031)10.1(\f)3.3(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC 8.001 0 Td [(\216)122(.)7.3(\003)-2.3(.)7.8(, )]TJ 0 Tw -20.455 -1.218 Td [(\004)8.8(\027)-0.9(\032)5.9(\203)5.5(\022)-2.3(\f)11.6(\017)0.7(\027)6.5(\021)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.9(.)27.5(\221)18.5(.)7.8(, \004)15.2(\022)4.7(\032\031)5.9(\b)3.7(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)43.7(\205)-2.1(.)]TJ /T1_0 1 Tf 0 -1.218 TD [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.679 Tw [( \221)19.2(\r)-4.2(\032\030)5.3(\005)5.3(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.4(.)43.8(\205)-2.1(.)7.8(, \003)6.4(\b)3.7(\027)2.7(\235)7.7(\n)12.7(\022)7.3(\025)9.5(\020)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)28.5(\211)24.3(.)7.9(, )]TJ 0 Tw T* [(\202)15.6(\031)4.9(\032)7.8(\255)18.5(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.9(.)27.5(\224)26.6(.)7.8(, \004)15.1(\022)4.8(\032\031)5.9(\b)3.7(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)43.7(\205)-2.1(.)]TJ /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf -0.005 Tc 0.005 Tw [( M)5.5(i)2.9(kha)-7(i)2.4(l)]TJ /Span<>> BDC 16.384 0 Td ( )Tj EMC [(S)-2.9(.)]TJ /Span<>> BDC 0.99 0 Td ( )Tj EMC [(B)2(u)1.1(r)-3.6(d)-8(y)-1.2(uk)7.9(o)-5.6(v)]TJ /T1_0 1 Tf 0 Tc 1.563 Tw -17.374 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.8(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-44.6(s)2.3(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -0.043 Tw T* [(N)8.7(a)-2(i)9.4(r)7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(H)9.7(a)-5.9(y)-2(r)7.7(a)-0.8(p)-7.2(e)-4.4(t)-30(y)3.8(a)-0.7(n)-6(, I)3.2(ld)1.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)26(al)4.3(i)9.3(u)2.8(l)4.3(i)8.4(n)-6(, A)3.6(l)4.9(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)5.8(v)7.6(o)12.3(z)8.8(d)-0.9(e)-4(v)33.6(, )]TJ -0.061 Tw T* [(V)25.9(al)4.8(e)-1.7(r)-35.3(i)3.5(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)3.8(a)3.5(b)0.9(t)-29(s)4.9(e)-4(v)10.8(a)-14(, G)4.7(r)-35.3(i)5.8(g)-2.5(o)1.3(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)1.4(r)2.4(o)-1.1(l)4.8(e)-4(v)33.6(, O)-6(x)5(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(P)30.8(a)1.7(k)11.6(l)4.3(i)8.4(n)4.8(a)-14(, )]TJ 0.07 Tw T* [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(us)4.9(e)-4(v)10.8(a)-14(, I)3.2(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(I)14(v)10.8(a)-0.8(n)1.9(o)-0.6(v)33.6(, M)5.2(a)1.7(k)-17.5(s)-8.3(i)8.5(m)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-5.5(o)2.8(k)5.3(h)5.2(m)4.3(a)-4.9(t)1.4(o)-0.6(v)33.6(, )]TJ 1.264 Tw T* [(T)49.7(a)-4.9(t)-25.2(i)5.9(a)-0.7(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8(i)7.9(k)13(o)-1.1(l)3.3(a)-2(i)2.6(c)1.8(h)8.2(u)4.6(k)-17.4(, V)25.9(a)-3(s)-8.3(i)7.4(l)4.4(iy)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)21.5(i)3(d)-0.9(o)1.3(r)-35.3(i)8.4(n)-6(, )]TJ -0.002 Tc 0.002 Tw T* [(D)-8.1(e)-4.6(n)4.2(i)9(s)]TJ /Span<>> BDC 2.107 0 Td ( )Tj EMC [(D)21.9(.)]TJ /Span<>> BDC 1.047 0 Td ( )Tj EMC [(S)14.3(ta)-1.8(r)0.9(che)-4.6(n)5.5(k)10.9(o)-2.6(v)]TJ /T1_0 1 Tf 0 Tc 0.899 Tw -3.155 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.1(:)]TJ /T1_2 1 Tf [( N)8.8(a)-2(i)9.4(r)7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(H)9.7(a)-5.9(y)-2(r)7.7(a)-0.8(p)-7.2(e)-4.4(t)-29.9(y)3.8(a)-0.8(n)-6(, )]TJ -0.002 Tw T* [(I)3.2(ld)1.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)25.9(al)4.3(i)9.3(u)2.8(l)4.3(i)8.4(n)-6(, A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)5.8(v)7.6(o)12.3(z)8.8(d)-1(e)-3.9(v)33.5(, V)25.9(al)4.8(e)-1.7(r)-35.3(i)3.4(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)3.8(a)3.5(b)0.9(t)-29.1(s)4.9(e)-3.9(v)10.8(a)-14(, )]TJ 0 Tw T* [(G)4.7(r)-35.3(i)5.8(g)-2.5(o)1.3(r)-40.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)1.3(r)2.4(o)-1.1(l)4.9(e)-4(v)33.6(, I)3.2(l)11(y)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(B)10.2(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24.1(e)-1.7(r)-27.8(\243)8(l)4.8(e)-4(v)33.6(,)-20.4(S)5.6(e)-1.7(r)2.3(g)-2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)-7.4(i)9.4(r)2.4(o)-4.4(g)-2.5(ov)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.382 Tw 3.238 0 Td [( M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)7(u)6.1(r)1.5(d)-3(y)3.8(u)4.6(k)12.9(o)-0.6(v)33.6(, N)8.7(a)-4.9(t)2.3(al)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)2.8(g)-2.5(e)-2.5(y)5.7(k)-18.5(i)8.4(n)4.8(a)-14(, )]TJ 0 Tw -3.238 -1.218 Td [(I)7.5(r)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(. K)13.3(o)1.3(r)-14.6(z)8.1(h)1.9(e)-4(v)10.8(a)-13.9(, S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)-7.3(i)9.4(r)2.4(o)-4.4(g)-2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\034\025\203\017\022\215\032\037\034\223 \017\224 \032\026\020\017\022\032\ \225 \(ORCID\))Tj /T1_0 1 Tf 0.255 Tw 0 -1.218 TD (\207\031\030\007\033\022\024\r \204\017\b\026\017\035 \222\036\030\020\036\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tw (-)Tj 0.174 Tw T* [(\235\036\007\030\t )0.5(\220\027\007\024\f\022\024\023\017\017 )0.6(\205\206\207\210\211 )0.5(\212\215\210 )0.5(\217\204\202\203\215\210 )0.6(\204\017\027\007\030\026\r\026 )]TJ 0.107 Tw T* (\217\024\f\f\017\017, \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\ \021 \206\207\211\003 \253\204\024\f\022\024\r\f\022\017\005 \n\027\024\020\ \024)Tj 0 Tw (-)Tj 0.518 Tw T* [(\023\030\024\235\017\035\034\027\t\005 )0.6(\022\035\017\027\017\022\024-\007\017\026\020\027\024\f\021\017\004\036\f\ \022\017\005 )0.6(\006\036\027\021\030 )0.6(\017\n. )]TJ 0.352 Tw T* (\222.\215.)Tj /Span<>> BDC ( )Tj EMC (\207\024\021\022\017\027\026 \212\003\204\273, \030\031\022\024\r\024\007\ \017\021\036\035\034 \006\036\027\021\030\026 \220\027\007\024\b\017)Tj 0 Tw (-)Tj 0.07 Tw T* (\030\031\030\020\017\017 \205\036\007\036\030\026\035\034\027\026\016 \f\ \036\021\034 \022\035\017\027\017\022 \253\213\r\030\024\024\027\022\024\ \273; ORCID )Tj 0 Tw T* (0000-0003-4690-9335)Tj -0.039 Tw T* (\202\005\030\026\023\036\021\016\027 \203\026\017\030\026 \202\027\007\030\ \026\027\017\022\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.232 Tw T* [(\206\207\211\003 )0.5(\253\204\024\f\022\024\r\f\022\017\005 )0.6(\n\027\024\020\024\023\030\024\235\017\035\034\027\t\005 )0.6(\022\035\017\027\017\022\024-\007\017\026)]TJ 0 Tw (-)Tj 0.222 Tw T* (\020\027\024\f\021\017\004\036\f\022\017\005 \006\036\027\021\030 \017\n\ . \222.\215.)Tj /Span<>> BDC ( )Tj EMC (\207\024\021\022\017\027\026 \212\003\204\273; ORCID )Tj 0 Tw T* (0000-0002-7295-8037)Tj 0.434 Tw T* [(\200\026\035\017\031\035\017\027 \230\035\034\007\026\030 )0.5(\217\026\031\235\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0005-6110-8941)Tj -0.077 Tw T* (\206\r\024\007\036\r \202\035\036\022\f\036\005 \202\035\036\022\f\026\027\ \007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\r\036\007\031\033\013\017\005 \024\021\007\036)Tj 0 Tw (-)Tj -0.031 Tw T* (\035\036\027\017\036\n \220\027\007\024\f\022\024\023\017\017 \206\207\211\ \003 \253\206\025\207 \017\n. \230.\200.)Tj /Span<>> BDC ( )Tj EMC (\212\026\r\t\007\024\r\f\022\024\020\024 )Tj 0 Tw T* (\212\003\204\273; ORCID 0000-0002-3096-2070)Tj 0.588 Tw T* (\025\024\030\024\035\036\r \206\030\017\020\024\030\017\005 \202\035\036\ \022\f\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 0.109 Tw T* [(\220\027\007\024\f\022\024\023\017\f\021 \205\206\202\211 \253\203\026\006\ \017\024\027\026\035\034\027\t\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 \017\f)]TJ 0 Tw (-)Tj 0.167 Tw T* [(\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 )0.5(\006\036\027\021\030 \007\024\030\024\r\034\016 \007\036\021\036\005\273\ \204\017\027\007\030\026\r\026 )]TJ 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0001-5730-3684)Tj 0.269 Tw 23.244 64.543 Td [(\215\026\022\035\017\027\026 )0.5(\210\022\f\026\027\026 )0.6(\200\035\026\007\017\n\017\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.923 0 Td [(\227 )0.5(\007.\n.\027., )0.5(\027\026\031\004\027\t\005 )]TJ 0.257 Tw -13.923 -1.218 Td [(\022\024\027\f\031\035\034\021\026\027\021 )0.6(\035\026\002\024\030\026\021\024\030\017\017 )0.5(\017\027\027\024\r\026\006\017\024\027\027\024\005 )0.5(\023\026\021\024\n\024\030)]TJ 0 Tw (-)Tj 0.337 Tw T* (\235\024\035\024\020\017\017 \206\207\211\003 \253\204\024\f\022\024\r\f\ \022\017\005 \022\035\017\027\017\004\036\f\022\017\005 \027\026\031\004\ \027\t\005 )Tj 0.08 Tw T* (\006\036\027\021\030 \017\n. \202.\222.)Tj /Span<>> BDC ( )Tj EMC (\214\024\020\017\027\024\r\026\273 \212\003\204, \020\035\026\r\027\t\005\ \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj -0.084 Tw T* (\021\030\031\007\027\017\022 \035\026\002\024\030\026\021\024\030\017\017\ \220\035\036\022\021\030\024\027\027\024\005 \n\017\022\030\024\f\022\024\ \023\017\017 \205\206\207\211 )Tj 0.773 Tw T* (\253\203\026\006\017\024\027\026\035\034\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\ \005 )Tj 0.246 Tw 0 -1.218 TD (\006\036\027\021\030 \b\017\030\031\030\020\017\017 \017\n. \202.\200.)Tj /Span<>> BDC ( )Tj EMC (\200\017\001\027\036\r\f\022\024\020\024\273 \204\017\027\007\030\026\r\ \026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017; ORCID 0000-0001-6373-1888)Tj 0.07 Tw T* (\217\016\002\006\036\r\026 \200\026\035\036\030\017\016 \230\020\024\030\ \036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj 0.271 Tw T* (\021\030\031\007\027\017\022, \026\f\023\017\030\026\027\021 \024\021\007\ \036\035\026 \220\027\007\024\f\022\024\023\017\017, \204\024\f\022\024\r\ \f\022\017\005 )Tj 0.078 Tw T* (\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034\f\ \022\017\005 \024\027\022\024\035\024\020\017\004\036\f\022\017\005 \017\ \027\f\021\017\021\031\021 )Tj 0.138 Tw T* (\017\n. \215.\202.)Tj /Span<>> BDC ( )Tj EMC (\206\036\030\006\036\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \205\206\207\211 \253\203\204\230\037 \030\ \026\007\017\024\035\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; O\ RCID 0000-0003-3174-7695)Tj 0.066 Tw 0 -1.218 TD (\202\020\036\005\022\017\027\026 \203\026\021\026\035\034\016 \200\035\026\ \007\017\n\017\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031\033)Tj 0 Tw (-)Tj -0.03 Tw 0 -1.218 TD (\013\026\016 \024\021\007\036\035\036\027\017\036\n \220\027\007\024\f\022\ \024\023\017\017 \025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 )Tj -0.02 Tw T* (\215\030\036\f\027\036\273, \202\210 \253\204\213\212\222\230-2\273; ORC\ ID 0000-0001-8726-0929)Tj 0.17 Tw T* (\206\031\f\036\r\026 \213\r\020\036\027\017\016 \200\035\026\007\017\n\017\ \030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0009-3782-8366)Tj 0.35 Tw T* (\230\r\026\027\024\r \230\035\034\016 \230\020\024\030\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 \025\212\037\ )Tj 0.121 Tw T* (\253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; ORCID )Tj 0 Tw T* (0009-0002-8492-2856)Tj 0.033 Tw T* (\025\024\030\032\036\r\026 \230\030\017\027\026 \224\030\034\036\r\027\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \030\031\022\024\r\024\007\017\021\036\035\034 \220\027\ )Tj 0 Tw (-)Tj 0.194 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\020\024 \006\036\027\021\030\026\ , \f\021\026\030\001\017\005 )0.5(\027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 )]TJ 0.232 Tw T* [(\206\207\211\003 )0.5(\253\204\024\f\022\024\r\f\022\017\005 )0.6(\n\027\024\020\024\023\030\024\235\017\035\034\027\t\005 )0.6(\022\035\017\027\017\022\024-\007\017\026)]TJ 0 Tw (-)Tj 0.11 Tw T* (\020\027\024\f\021\017\004\036\f\022\017\005 \006\036\027\021\030 \017\n\ . \222.\215.)Tj /Span<>> BDC ( )Tj EMC (\207\024\021\022\017\027\026 \212\003\204\273, \026\r. \022\026)Tj 0 Tw (-)Tj 0.093 Tw T* (\235\036\007\030\024\005 \220\027\007\024\f\022\024\023\017\017 \205\206\ \207\210\211 \212\215\210 \217\204\202\203\215\210 \204\017\027\007\030\ \026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0002-5984-5660)Tj 0.358 Tw T* (\214\024\b\n\026\021\024\r \204\026\022\f\017\n \204\017\b\026)Tj /Span<>> BDC (\005)Tj EMC (\035\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \020\035\026\r\027\t\005 )Tj 0.225 Tw T* [(\027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022, )0.5(\026\r\036\007\031\033\013\017\005 \024\021\007\036\035\036\027\017\036\ \n \220\027\007\024)]TJ 0 Tw (-)Tj 0.551 Tw T* (\f\022\024\023\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\ \017)Tj /Span<>> BDC (\005)Tj EMC ( \205\206\202\211 \253\203\026\006\017\024\027\026\035\034\027\t\005 )Tj 0.583 Tw T* (\n\036\007\017\006\017\027\f\022\017\005 \017\f\f\035\036\007\024\r\026\021\ \036\035\034\f\022\017\005 \006\036\027\021\030 \007\024\030\024\r\034\016\ )Tj 0.641 Tw T* (\007\036\021\036\005\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\ \017, \023\030\024\235\036\f\f\024\030 \022\026\235\036\007\030\t )Tj 0.792 Tw T* (\007\036\021\f\022\024\005 \b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\035\024\020\017\017-\026\027\007\030\024\035\024\020\017\017\ \017\n. )Tj 0.251 Tw T* (\214.\215.)Tj /Span<>> BDC ( )Tj EMC (\202\035\036\022\f\026\027\007\030\024\r\026, \205\206\202\210\211 \200\210\ \215\036\030\r\t\005 \204\024\f\022\024\r\f\022\017\005 )Tj 0.586 Tw T* [(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.6(\n\036\007\017\006\017\027\f\022\017\005 )0.6(\031\027\017\r\036\030\f\017\021\036\021 )0.5(\017\n\036)]TJ 0 Tw (-)Tj 0.361 Tw T* (\027\017 \230.\204.)Tj /Span<>> BDC ( )Tj EMC (\222\036\004\036\027\024\r\026 \204\017\027\017\f\021\036\030\f\021\r\026\ \007\030\026\r\024\024\b\030\026\027\036\027\017\016 )Tj 0.171 Tw T* (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017 \ \(\222\036\004\036\027\024\r\f\022\017\005 \211\027\017\r\036\030\f\017\021\ \036\021\); )Tj 0 Tw T* (ORCID 0000-0002-8305-7592)Tj -0.058 Tw T* [(\203\017\022\024\035\026\005\004\031\022 \221\026\021\034\016\027\026 )0.5(\200\017\022\021\024\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0008-4899-7221)Tj 0.794 Tw T* (\215\036\030\235\017\035\034\036\r \230\035\034\016 \207\024\030\017\f\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 0.444 Tw T* (\220\027\007\024\f\022\024\023\017\f\021, \205\017\035\017\026\035 \253\210\ \027\022\024\035\024\020\017\004\036\f\022\017\005 \006\036\027\021\030 \ \2231 )Tj 0.058 Tw T* (\206\024\030\024\007\f\022\024\005 \022\035\017\027\017\004\036\f\022\024\ \005 \002\024\035\034\027\017\006\t \017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 )Tj 0 Tw T* (\212\003\204\273; ORCID 0000-0002-2685-8721)Tj -0.063 Tw T* (\215\017\030\024\020\024\r \222\036\030\036\005 \222\036\030\020\036\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031\033\013\017\005 \024\021\007\036\ )Tj 0 Tw (-)Tj 0.064 Tw T* [(\035\024\n )0.5(\220\027\007\024\f\022\024\023\017\017, )0.5(\204\024\f\022\024\r\f\022\017\005 )0.5(\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034)]TJ 0 Tw (-)Tj 0.17 Tw T* (\f\022\017\005 \024\027\022\024\035\024\020\017\004\036\f\022\017\005 \017\ \027\f\021\017\021\031\021 \017\n. \215.\202.)Tj /Span<>> BDC ( )Tj EMC (\206\036\030\006\036\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.074 Tw T* (\235\017\035\017\026\035 \205\206\207\211 \253\203\204\230\037 \030\026\007\ \017\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\ \f\f\017\017; )Tj 0 Tw T* (ORCID 0000-0002-8101-2155)Tj -0.076 Tw T* (\222\017\007\024\030\017\027 \200\026\f\017\035\017\005 \200\035\026\007\ \017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0003-1836-7492)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8526 56.0378 Tm (178)Tj ET endstream endobj 106 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (4.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\231\b\240\002\217\002\b\002\n\006\004\226\t\201\r\217\220\002\r \t\217\217\ \f\r\240\002\004\b\t\r \(\231\222\255\))Tj -1.352 -1.218 Td (\037\r\f\001: )Tj /T1_2 1 Tf 0.015 Tw 2.704 0 Td (\031\f\021\026\027\024\r\017\021\034 \f\035\024\005 \024\002\030\026\024\ \r\026\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \024\027\024 )Tj 0 Tw -2.704 -1.218 Td (\017\f\b\024\007\017\021, \036\020\024 \f\021\030\031\022\021\031\030\031\ \017)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\020\036\027\027\024\f\021\034.)Tj /T1_1 1 Tf 0 -1.218 TD (\017\217\b\002\b\013\r \212\006\t\213\b\004\220\t \f\t\212\002\214\013:\ )Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\206\017\023\036\030\220\b\024\020\036\027\027\026\016 \024\007\027\024\030\ \024\007\027\026\016 \f\021\030\031\022\021\031\030\026.)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\230\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024\ \f\035\024\005\).)Tj -0.233 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\232\036\021\022\017\036 )-233(\020\030\026\027\017\006\t.)]TJ -0.024 Tw T* (\226)Tj /Span<>> BDC [( )-291( )]TJ EMC 1.056 0 Td (\222\r\024\002\024\007\027\026\016 \022\024\n\023\030\036\f\f\017\016 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\026\r\035\017\r\026\027\017\017 \007\017\f\021\026\035\034)Tj 0 Tw (-)Tj T* (\027\t\n \022\024\027\006\024\n \220\b\024\220\027\007\024\f\022\024\023\ \026.)Tj /T1_1 1 Tf -1.056 -1.218 Td (\033\b\004\201\t\214\013\r \212\004\006\004\214\r\003\006\013:)Tj /T1_2 1 Tf 0.029 Tw T* (\226)Tj /Span<>> BDC [( )-238( )]TJ EMC 1.056 0 Td [(\215\036\030\r\t\005 \f\035\024\005: \206\017\023\036\030\220\b\024\020\036\ \027\027\t\005 )0.5(\(\f\035\017\017\f\021\026\016 )0.5(\024\002\024\035\024\004)]TJ 0 Tw (-)Tj T* (\022\026\), \017\027\021\026\022\021\027\t\005.)Tj 0.092 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-175( )]TJ EMC 1.056 0 Td (\200\021\024\030\024\005 \f\035\024\005: \206\017\023\024\220\b\024\020\036\ \027\027\t\005 \(\n\t\001\036\004\027\026\016 \023\035\026\f\021\017\027\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\022\026 \f\035\017\017\f\021\024\005\), \017\027\021\026\022\021\027\t\ \005.)Tj -0.015 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-282( )]TJ EMC 1.056 0 Td (\221\030\036\021\017\005 \f\035\024\005: \206\017\023\036\030\220\b\024\020\ \036\027\027\t\005 \(\023\024\007\f\035\017\017\f\021\t\005 \f\035\024\005\ , )Tj 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \017\f\b\024\007\017\021 \035\017\023\024\ \n\026\).)Tj 0.179 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-88( )]TJ EMC 1.056 0 Td [(\232\036\021\r\036\030\021\t\005 \f\035\024\005: \206\017\023\024\220\b\024\ \020\036\027\027\t\005 )0.5(\(\n\t\001\036\004\027\026\016 )0.5(\024\002\024)]TJ 0 Tw (-)Tj T* (\035\024\004\022\026\), \017\027\021\026\022\021\027\t\005.)Tj -0.018 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-285( )]TJ EMC 1.056 0 Td [(\215\016\021\t\005 \f\035\024\005: \206\017\023\036\030\220\b\024\020\036\ \027\027\t\005 )0.5(\(\f\036\030\024\027\026\016 \024\002\024\035\024\004\022\026\), )]TJ 0 Tw T* (\017\027\021\026\022\021\027\t\005.)Tj /T1_1 1 Tf -1.056 -2.436 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\031\t\226\226\r\006\r\b\204\t\004\f\001\b\004\235 \240\t\004\n\b\002\217\ \003\t\220\004)Tj -1.352 -1.218 Td (\037\r\f\001: )Tj /T1_2 1 Tf 0.261 Tw 2.95 0 Td (\024\021\035\017\004\017\021\034 \035\017\023\024\n\031 \024\021 \007\030\ \031\020\017\b \017\027\021\030\026\n\031\030\026\035\034\027\t\b )Tj 0 Tw -2.95 -1.218 Td (\024\002\030\026\024\r\026\027\017\005)Tj /T1_1 1 Tf T* (\215\r\003\002\240\013 \217\006\004\b\r\b\t\235:)Tj /T1_2 1 Tf 0.03 Tc 0.267 Tw T* (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf -0.03 Tw 1.116 0 Td (\027\034\255\017: )Tj /T1_2 1 Tf 0.533 Tw 3.45 0 Td [(\206\017\023\024\220\b\024\020\036\027\027\t\036 )0.5(\024\002\030\026\024\r\026\027\017\016, )0.5(\017\f\b\024\007\016)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.5 Tw -3.45 -1.218 Td (\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC [(2/4 \220\b\024\f\035\024\016; \r\024\n\024\032\027\t \220\b\024\020\036\ \027\027\t\036)30( )]TJ -0.03 Tw T* (\r\022\035\033\004\036\027\017\016.)Tj 0 Tc 0.267 Tw -1.116 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\035\r\005\002\214\t\002\214\004: )Tj /T1_2 1 Tf 0.03 Tw 5.505 0 Td (\206\017\023\024\220\b\024\020\036\027\027\t\036 \024\002\030\026\024\r\ \026\027\017\016, \017\f\b\024\007\016)Tj 0 Tw (-)Tj -5.505 -1.218 Td (\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (2 \017\035\017 4 \220\b\024\f\035\024\016; \020\024\n\024\020\036\027\027\ \026\016 \f\021\030\031\022\021\031\030\026.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\016\004\b\b\002\214\004: )Tj /T1_2 1 Tf 0.16 Tw 5.246 0 Td [(\206\017\023\024\220\b\024\020\036\027\027\t\036 )0.6(\024\002\030\026\024\r\026\027\017\016, )0.6(\017\f\b\024\007\016)]TJ 0 Tw (-)Tj 0.043 Tw -5.246 -1.218 Td (\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (2 \017\035\017 3 \220\b\024\f\035\024\016; \021\030\036\002\031\036\021 \ \020\017\f\021\024\035\024\020\017\004\036\f\022\024\020\024 )Tj 0 Tw T* (\026\027\026\035\017\026 \007\035\016 \021\024\004\027\024\005 \017\007\ \036\027\021\017\235\017\022\026\006\017\017.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\025\231\017: )Tj /T1_2 1 Tf 0.09 Tw 2.348 0 Td (\222\030\036\007\027\036\023\024\027\017\032\036\027\027\026\016 \017\035\ \017 \017\024\220\b\024\020\036\027\027\026\016 \f\021\030\031\022)Tj 0 Tw (-)Tj -2.348 -1.218 Td (\021\031\030\026, \004\036\021\022\017\036 \022\024\027\021\031\030\t; \017\ \f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (2 \017\035\017 3 \220\b\024\f\035\024\016.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\026\203\200: )Tj /T1_2 1 Tf -0.024 Tw 2.442 0 Td (\206\017\023\024\220\b\024\020\036\027\027\t\036 \024\002\030\026\024\r\ \026\027\017\016, \017\f\b\024\007\016\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (2 )Tj 0 Tw -2.442 -1.218 Td (\017\035\017 3 \220\b\024\f\035\024\016; \027\036\004\036\021\022\017\036\ \022\024\027\021\031\030\t.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\032\200\207: )Tj /T1_2 1 Tf -0.02 Tw 2.526 0 Td (\206\036\021\036\030\024\020\036\027\027\026\016 \f\021\030\031\022\021\031\ \030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\017\n\017 \020\017\023\036\030\220\b\024)Tj 0 Tw (-)Tj -0.022 Tw -2.526 -1.218 Td (\020\036\027\027\t\n\017 \r\022\035\033\004\036\027\017\016\n\017, \027\026\ \035\017\004\017\036 \023\030\024\021\024\022\024\r\024\005 \f\017\f\021\ \036)Tj 0 Tw (-)Tj T* (\n\t; \017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (3 \017\035\017 4 \220\b\024\f\035\024\016.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.276 Tw 1.056 0 Td (\031\210\212\f\t\220\004\204\t\002\b\b\013\r \220\t\217\003\013: )Tj /T1_2 1 Tf (\206\024\n\024\020\036\027\027\t\036 \026\027\220\b\024\020\036\027)Tj 0 Tw (-)Tj 0.187 Tw T* (\027\t\036 \017\035\017 \020\017\023\024\220\b\024\020\036\027\027\t\036\ \024\002\030\026\024\r\026\027\017\016, \017\f\b\024\007\016\013\017\036\ )Tj 0.18 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (3 \220\b\024\f\035\024\016; \002\036 \022\030\024\r\024\021\024\022\026\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\023\035\036\030\024\r\f\022\024\n )Tj 0 Tw T* (\f\022\026\027\017\030\024\r\026\027\017\017.)Tj /T1_1 1 Tf 0.043 Tw -1.056 -2.436 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\215\002\006\226\002\f\002\n\t\201\r\217\220\004\235 \r\006\t\226\t\220\ \004\204\t\235 \(\212\006\t \212\002\240\002\213\006\r)Tj 0 Tw (-)Tj -1.352 -1.218 Td (\b\t\t \b\004)Tj /Span<>> BDC ( )Tj EMC (\213\f\002\220\004\201\r\217\003\r\b\b\002\r \212\r\006\r\006\002\202\240\ \r\b\t\r\))Tj T* (\215\r\003\002\240\013:)Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\264\017\023\006\024\r\026\016 \(\r \021.\004. \f\021\031\023\036\027\004\ \026\021\026\016\) \002\017\024\023\f\017\016.)Tj 0.183 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-84( )]TJ EMC 1.056 0 Td (\207\017\024\023\f\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\r\026\030\017\021\036\035\034\027\t\n \030\026\030\036\ \024\n \f\035\017\017\f\021\024\005 )Tj 0 Tw T* (\024\002\024\035\024\004\022\017.)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\221\024\027\022\024\017\020\024\035\034\027\026\016 \002\017\024\023\f\017\ \016 \023\024\007 \022\024\027\021\030\024\035\036\n \233\211\222-\221\230\ \215.)Tj 0.449 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )182( )]TJ EMC 1.056 0 Td (\215\024\035\027\024\036 \031\007\026\035\036\027\017\036 \024\002\030\026\ \024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 )Tj 0 Tw T* (\020\017\f\021\024\035\024\020\017\036\005.)Tj /T1_1 1 Tf 22.188 64.543 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\022\r\230\r\b\t\r \002)Tj /Span<>> BDC ( )Tj EMC (\003\004\220\003\t\220\r \f\r\201\r\b\t\235)Tj -0.01 Tw -1.352 -1.218 Td [(\036\217\f\t \f\t\212\002\214\004 \240\002\206\006\002\220\004\201\r\217\ \003\r\b\b\004\235 )0.5(\(\212\002 \240\004\b\b\013\214 \231\222\255\):)]TJ /T1_2 1 Tf 0.071 Tw T* (\226)Tj /Span<>> BDC [( )-196( )]TJ EMC 1.056 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (10 \n\n )Tj /C2_0 1 Tf 0 Tw <013A>Tj /T1_2 1 Tf 0.071 Tw ( \022\024\027\021\030\024\035\034\027\026\016 \233\206\212\222 \004\036\030\ \036 )Tj 0 Tw T* (2\2263 \020\024\007\026.)Tj -0.036 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-303( )]TJ EMC 1.056 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b 10\22620 \n\n )Tj /C2_0 1 Tf 0 Tw <013A>Tj /T1_2 1 Tf -0.036 Tw ( \022\024\027\021\030\024\035\034\027\026\016 \233\206\212\222 \004\036\030\ \036 )Tj 0 Tw T* (1\2262 \020\024\007\026.)Tj 0.082 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-185( )]TJ EMC 1.056 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 1.936 0 Td (\030\026\n\036\030\026\b)Tj /Span<>> BDC ( )Tj EMC 4.154 0 Td (>)Tj /Span<>> BDC ( )Tj EMC [(20 )0.5(\n\n \017\035\017 )0.5(\027\026\035\017\004\017\017 )0.5(\f\017\n\023\021\024\n\024\r )]TJ /C2_0 1 Tf 0 Tw 13.965 0 Td <013A>Tj /T1_2 1 Tf ( )Tj -20.054 -1.218 Td (\031\007\026\035\036\027\017\036.)Tj /T1_1 1 Tf 2.886 Tw -1.056 -1.218 Td (\036\217\f\t \212\002\240\002\213\006\r\004\r\003\217\235 \213\f\002\220\ \004\201\r\217\003\r\b\b\002\r )Tj 0 Tw T* (\212\r\006\r\006\002\202\240\r\b\t\r:)Tj /T1_2 1 Tf 0.05 Tw T* (\226)Tj /Span<>> BDC [( )-217( )]TJ EMC 1.056 0 Td (\230\f\023\024\035\034\024\r\026\027\017\036 \007\024\023\024\035\027\017\ \021\036\035\034\027\t\b \n\036\021\024\007\024\r \007\017\026\020\027\024\ \f)Tj 0 Tw (-)Tj T* (\021\017\022\017 \(\204\222\025\221, \204\217\221, \007\024\023\023\035\036\ \030\024\r\f\022\024\036 \f\022\026\027\017\030\024\r\026\027\017\036\).\ )Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\216\017\030\031\030\020\017\004\036\f\022\024\036 \017\035\017 \220\027\ \007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\036\027\ \017\036.)Tj /T1_1 1 Tf -1.056 -2.436 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\215\r\003\002\240\013 \210\240\004\f\r\b\t\235 \f\t\212\002\214\013)Tj -1.352 -1.218 Td (\231\b\240\002\217\220\002\212\t\201\r\217\220\t\r \214\r\003\002\240\013\ :)Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\217\036\036\022\006\017\016 \f\035\017\017\f\021\024\005 \024\002\024\ \035\024\004\022\017 \(EMR\).)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\212\017\f\f\036\022\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \(ESD\).)Tj 1.748 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )1481( )]TJ EMC 1.056 0 Td [(Hybr)-37(id-\n\036\021\024\007 p)25(r)-23.9(ecut-EMR \007\035\016 \f\035\024\032\027\024\005 )]TJ 0 Tw T* (\035\024\022\026\035\017\026\006\017\017.)Tj /T1_1 1 Tf -1.056 -1.218 Td (\225\t\006\210\006\n\t\201\r\217\220\t\r \214\r\003\002\240\013:)Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\221\024\030\026\022\024\f\022\024\023\017\004\036\f\022\017\036 \024\023\ \036\030\026\006\017\017 \(\007\035\016 \023\017\013\036\r\024\007\026\)\ .)Tj 0.951 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )684( )]TJ EMC 1.056 0 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\036 \024\023\ \036\030\026\006\017\017 \(\007\035\016 \032\036\035\031\007\022\026 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\026\).)Tj 0.031 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-236( )]TJ EMC 1.056 0 Td [(\210\021\022\030\t\021\t\036 \024\023\036\030\026\006\017\017 \(\023\030\ \017 )0.5(\027\036\r\024\n\024\032\027\024\f\021\017 \220\027\007\024\f\022\024)]TJ 0 Tw (-)Tj T* (\023\017\004\036\f\022\024\020\024 \007\024\f\021\031\023\026\).)Tj /T1_1 1 Tf -1.056 -2.436 Td (\021\f\211\201\r\013\r \230\004\n\t \004\f\n\002\006\t\003\214\004:)Tj 0.125 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\231\027\031\255/\021\255 )Tj /Span<>> BDC ( )Tj EMC (\206\r\f\002\214 \217\r\003\r)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 10.576 0 Td <013A>Tj /T1_2 1 Tf 0.125 Tw ( \210\023\030\036\007\036\035\036\027\017\036 \235\024\030\n\t, )Tj 0 Tw -11.928 -1.218 Td (\006\r\036\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\017\f\021\036\027\006\017\017 \024\002\030\026\024\r\026\ \027\017\016.)Tj /T1_1 1 Tf 0.179 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\200\004\f\001\212\004\003\002\006\b\013\r \003\r\217\003\013)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 9.674 0 Td <013A>Tj /T1_2 1 Tf 0.179 Tw ( \215\024\007\021\r\036\030\032\007\036\027\017\036 \n\016\020\022\024)Tj 0 Tw (-)Tj -11.026 -1.218 Td (\f\021\017, \253\f\017\n\023\021\024\n \023\024\007\031\001\022\017\273,\ \253\f\017\n\023\021\024\n \001\026\021\030\026\273.)Tj /T1_1 1 Tf 0.267 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC (\231\222\255)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 3.297 0 Td <013A>Tj /T1_2 1 Tf 0.185 Tw [( )0.5(\210\006\036\027\022\026 )0.5(\f\035\024\016, )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.65 0 Td [(\022\024\021\024\030\024\020\024 )0.5(\017\f\b\024\007\017\021 )0.6(\024\002\030\026)]TJ 0 Tw (-)Tj 0.225 Tw -11.947 -1.218 Td [(\024\r\026\027\017\036 \(3 \220\b\024\f\035\024\005\), \220\b\024\020\036\ \027\027\024\f\021\017 )0.5(\(\020\017\023\036\030\220\b\024\020\036\027\027\026\016, )]TJ 0 Tw T* (\024\007\027\024\030\024\007\027\026\016 \f\021\030\031\022\021\031\030\026\ \).)Tj /T1_1 1 Tf 0.154 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\031\t\226\226\r\006\r\b\204\t\004\f\001\b\004\235 \240\t\004\n\b\002\217\ \003\t\220\004)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 14.991 0 Td <013A>Tj /T1_2 1 Tf 0.154 Tw ( \222\030\026\r\027\036\027\017\036 )Tj 0 Tw -16.343 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \017\027\021\030\026\n\031\030\026\035\034\027\ \t\n\017 \024\002\030\026\024\r\026\027\017\016\n\017.)Tj /T1_1 1 Tf 0.237 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\215\002\006\226\002\f\002\n\t\201\r\217\220\004\235 \r\006\t\226\t\220\ \004\204\t\235)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 14.849 0 Td <013A>Tj /T1_2 1 Tf 0.237 Tw ( \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024)Tj 0 Tw (-)Tj -16.201 -1.218 Td (\030\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\004\036\f\021\r\036\027\027\024\036 \023\036\030\036\030\ \024\032\007\036\027\017\036.)Tj /T1_1 1 Tf T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\025\004\206\f\211\240\r\b\t\r \t\f\t \f\r\201\r\b\t\r)Tj /T1_2 1 Tf (:)Tj 0.267 Tw -1.352 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\025\004\206\f\211\240\r\b\t\r: )Tj /T1_2 1 Tf 0.317 Tw 6.369 0 Td (\007\035\016 \002\036\f\f\017\n\023\021\024\n\027\t\b \035\017\023\024\n\ \n\026\035\t\b )Tj 0 Tw -6.369 -1.218 Td (\030\026\n\036\030\024\r.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\222\240\004\f\r\b\t\r: )Tj /T1_2 1 Tf 0.371 Tw 5.078 0 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (2 \f\n \017\035\017 \027\026\035\017\004\017\017 )Tj 0 Tw -5.078 -1.218 Td (\f\017\n\023\021\024\n\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 164.6418 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.174 Tw 10 0 0 10 274.9606 140.2858 Tm (\214\017\023\024\n\t \032\036\035\031\007\024\004\027\024-\022\017\001\036\ \004\027\024\020\024 \021\030\026\022\021\026 \016\r\035\016\033\021\f\016\ \024\007)Tj 0 Tw (-)Tj -0.014 Tw T* [(\027\017\n\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.5 0 Td [(\027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\024 )0.5(\r\f\021\030\036\004\026\033\013\017\b\f\016 )0.6(\024\002\030\026\024\r\026\027\017\005 )]TJ 0.139 Tw -3.5 -1.218 Td (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ \021\030\026\022\021\026. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 )Tj 0.072 Tw T* (\023\026\021\024\020\027\024\n\024\027\017\004\027\t\b \023\030\017\027\ \026\022\024\r, \023\024\r\024\035\016\033\013\017\b \022\024\030\030\036\ \022\021)Tj /Span<>> BDC (-)Tj EMC 0.185 Tw T* (\027\024 \023\024\f\021\026\r\017\021\034 \007\017\026\020\027\024, \023\ \030\017\n\036\027\036\027\017\036 \007\024\023\024\035\027\017\021\036\035\ \034\027\t\b )Tj 0.266 Tw T* (\n\036\021\024\007\024\r \024\002\f\035\036\007\024\r\026\027\017\016, \021\ \026\022\017\b \022\026\022 \220\027\007\024\f\024\027\024\020\030\026\235\ \017\016, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 505.6144 56.0378 Tm (177)Tj ET endstream endobj 104 0 obj <> endobj 276 0 obj [278 0 R] endobj 277 0 obj <>stream H\j0 ~ Cq !PZ9dE6sWqC O|4׆|0EpimG]cC}PU&xمJC4As8"%8B]^nFCDi9Z"BS4Ѐ:JPJ 7aq/gqũ}{ egfɓw> endobj 279 0 obj <> endobj 280 0 obj <> endobj 281 0 obj <>stream Hj` (H endstream endobj 282 0 obj <>stream HWwNWݿs`S4A%D$y+"ě ["_PRD)z"eQe״aU;7m%V5jK3;f V^7~޳>P 1tdxYr)f.xyq'#77HfnRF^<@_xO̴sb=|L^h8q*3o;sȒDMI( .s< a8-97m7|"<<{V~GhQރ@7#]5K(T-ǜ:<0jpl bh8n.b Z>]lՌ_yM{MwTymnlBKsi|",#(WüBO A2JC16yT[vG[ $-%ORO:F)#s1/72z؁)_3ZhD8Ir9oowm0 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Uɗ<_0='A |{ZUJ/RNj$I.L߿jy7#Q]S Bg 7ýW}}ߤRׂ>0Js"GZo2'ch;MW qmGRb/f7BL޷ gf`8b)g}pއ< CN{5.=TPJ|a0tk:pZ1An1 +*oR;iq.7YHr.]@RsU.^%%R-8Fɾ!6NDEntM1IQ.v:Qi63e3k|EN V_Kkvxq#5}/с;oe^x7Χ=Ɵv(7&'1 )ZJSb)c:_Wر|î]Uo(x~syyyyyY3-y%ײcX-&b!촧wmmlm"$.rZzbJck M5ƶDUyc<ےXޘ4}үwP0 $OJ+O>ASإ%b'9;&5KKZ@2\賤ϒšĹvcåK5 l΢ݘڪ}}R9Dj'IrE鳵HEq aIR"H M0 ZRW;QRz֋ kNzwuה]ÞuRW+:$غB<&,"8e=Rs2Cj? eᤳvN(>`(x~^ku|HPD3IZȦwgR 7 q~y{ CfpJ3B uǰi{@`SВ[J+1]tsӐJ#1TrS J!W1,*bN1AzSOjZmmG}P:-+miGړ0VumG!v"C3h0\D<]q WtncQUP Ǩ|H_!ˇ³!>'+ .b/a.xL8|(g"K<+&i AZO%!򳆈"Y>[ z*Qm8pS2 XG PMa k`T@i~`y+1c֪%xRQ~||JQA\Gy* Ӣ'S}Z4;)WOҗ< vE^|- @zQ0D[ endstream endobj 103 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.072 Tw 10 0 0 10 70.8661 724.8299 Tm (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td [(\020\024\n\024\020\036\027\027\024\036 \020\017\023\024\220\b\024\020\036\ \027\027\024\036 )0.5(\017\035\017 \026\027\220\b\024\020\036\027\027\024\036 )0.5(\024\002\030\026)]TJ 0 Tw (-)Tj -1 -1.218 Td (\024\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 \022\024\027\021\031\030\026\n\017;)Tj 0.244 Tw 0 -1.218 TD (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024\ \f\035\024\005\) \017\035\017 )Tj 0.445 Tw -1 -1.218 Td (\030\026\f\023\024\035\026\020\026\036\021\f\016 \r\027\036 \024\030\020\ \026\027\024\r \240\025\221. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\035\036\030\024\r)Tj 0 Tw (-)Tj 0.662 Tw T* [(\f\022\024\n \f\022\026\027\017\030\024\r\026\027\017\017 )0.5(\022\030\024\r\024\021\024\022 \027\036 \024\023\030\036\007\036\035\016\ \036\021\f\016. )]TJ 0.267 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\f\021\017 \022\017\f\021\t \n\024\020\031\021 \024\023\030\ \036\007\036\035\016\021\034\f\016 \023\036\030\036\020\024\030\024\007\022\ \017, )Tj 0.402 Tw 0 -1.218 TD (\023\030\024\f\035\036\032\017\r\026\036\021\f\016 \023\036\030\017\f\021\ \026\035\034\021\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \022\024\035\034\006\036\r\t\b )Tj 0 Tw 0 -1.218 TD (\f\024\022\030\026\013\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC ([54\22656].)Tj -0.042 Tw T* (\212\017\026\020\027\024\f\021\017\022\026 \007\026\027\027\024\005 \023\ \026\021\024\035\024\020\017\017 \r\022\035\033\004\026\036\021 \r\t\023\ \024\035\027\036\027\017\036 )Tj -0.045 Tw T* (\025\221 \(\023\030\036\007\023\024\004\021\017\021\036\035\034\027\024 \ \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\r\036\027\027\t\n \022\024\027\021\030\026\f\021\017\ \030\024\r\026)Tj 0 Tw (-)Tj 0.098 Tw T* (\027\017\036\n\), \204\217\221, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\ \036 \017\f\f\035\036\007\024\r\026\027\017\036, )Tj 0.139 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017 \233\211\222, \023\024\r\024\035\016\033\ \013\036\036 \024\023\030\036\007\036\035\017\021\034 \b\026\030\026\022\ \021\036\030 )Tj 0.077 Tw 0 -1.218 TD [(\024\002\030\026\024\r\026\027\017\016 \(\022\017\f\021\024\027\024\036\ )0.5(\017\035\017 \f\024\035\017\007\027\024\036\), \023\026\021\024\035\024\020\ \017\004\036)]TJ 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\f\022\017\036 \017\n\036\027\036\027\017\016 \f\035\017\017\f\021\024\ \005 \024\002\024\035\024\004\022\017 [56]. \217\024\035\034 \233\211\222\ -)Tj 0.273 Tw 0 -1.218 TD (\221\230\215 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \007\031\023\035\017\022\026\006\ \017\024\027\027\t\b \022\017\f\021 \024\f\021\026\036\021\f\016 )Tj 0.164 Tw T* (\f\023\024\030\027\024\005, \021\026\022 \022\026\022 \004\026\f\021\024\ \021\026 \017\027\235\017\006\017\030\024\r\026\027\017\016 \007\024\f\021\ \017\020\026\036\021 )Tj 0 Tw T* (14% [57].)Tj /T1_1 1 Tf 0.163 Tw T* (\031\t\004\n\b\002\217\003\t\201\r\217\220\t\005 \004\f\n\002\006\t\003\214\ \234\b\240\002\217\220\002\212\t\201\r\217\220\002\n\002 \t\217)Tj 0 Tw (-)Tj T* (\217\f\r\240\002\004\b\t\235 \f\t\212\002\214 \207\021\020 )Tj /T1_0 1 Tf (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (11\))Tj /T1_1 1 Tf 0.159 Tw 0 -2.436 TD (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\025\004\201\004\f\001\b\013\005 \234\003\004\212: \026\t\213\210\004\f\t\ \213\004\204\t\235 )Tj /Span<>> BDC ( )Tj EMC (\206\r\f\002\214 \217\r\003\r )Tj 0 Tw -1.352 -1.218 Td (\(\231\027\031\255/\021\255\))Tj 0 -1.218 TD (\037\r\f\001: )Tj /T1_0 1 Tf -0.012 Tw 2.676 0 Td [(\024\023\030\036\007\036\035\017\021\034 )0.6(\n\026\022\030\024\f\022\024\023\017\004\036\f\022\017\036 )0.6(\b\026\030\026\022\021\036\030\017\f\021\017\022\017 )]TJ 0 Tw -2.676 -1.218 Td (\024\002\030\026\024\r\026\027\017\016.)Tj /T1_1 1 Tf T* (\017\217\b\002\b\013\r \212\006\t\213\b\004\220\t:)Tj /T1_0 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\215\024\035\031\f\235\036\030\017\004\036\f\022\026\016 \017\035\017 \023\ \024\035\031\024\r\024\017\007\027\026\016 \235\024\030\n\026.)Tj 1.63 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )1363( )]TJ EMC 1.056 0 Td [(\203\036\017\n\036\027\201\027\027\026\016 )0.6(\f\035\017\017\f\021\026\016 )0.5(\024\002\024\035\024\004\022\026 )0.5(\027\026\007 )]TJ 0 Tw T* (\024\002\030\026\024\r\026\027\017\036\n.)Tj 0.862 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )595( )]TJ EMC 1.056 0 Td (\240\036\035\021\024\r\026\021\t\005 \024\021\021\036\027\024\022 \(\f\023\ \036\006\017\235\017\004\027\t\005 \023\030\017\027\026\022 )Tj 0 Tw T* (\035\017\023\024\n\t\).)Tj -0.233 Tw 22.188 35.316 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\204\016\020\022\026\016 )-232.9(\022\024\027\f\017\f\021\036\027\006\017\016.)]TJ /T1_1 1 Tf 0 Tw 0 -2.436 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\017\204\r\b\220\004 \006\004\213\214\r\006\002 \t)Tj /Span<>> BDC ( )Tj EMC (\214\r\217\003\002\212\002\f\002\202\r\b\t\235)Tj -1.352 -1.218 Td (\215\r\003\002\240\013:)Tj /T1_0 1 Tf 0.025 Tw 0 -1.218 TD (\226)Tj /Span<>> BDC [( )-242( )]TJ EMC 1.056 0 Td (\233\024\235\026\020\024\020\026\f\021\030\024\007\031\024\007\036\027\024\ \f\022\024\023\017\016 \(\233\206\212\222\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \023\017\013\036)Tj 0 Tw (-)Tj T* (\r\024\007\026, \032\036\035\031\007\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\017.)Tj -0.029 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-296( )]TJ EMC 1.056 0 Td (\025\024\035\024\027\024\f\022\024\023\017\016 \(\025\222\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \021\024\035\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\027\022\024\005 \022\017\001\024\022.)Tj /T1_1 1 Tf 0 Tw -1.056 -1.218 Td (\026\004\202\b\013\r \214\002\214\r\b\003\013:)Tj /T1_0 1 Tf -0.021 Tw T* (\226)Tj /Span<>> BDC [( )-288( )]TJ EMC 1.056 0 Td (\213\f\035\017 \030\026\n\036\030)Tj /Span<>> BDC ( )Tj EMC 5.268 0 Td (\234)Tj /Span<>> BDC ( )Tj EMC (2 \f\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\021 \f\017\n\023\021\024\n\024\r )Tj /C2_0 1 Tf 0 Tw 9.606 0 Td <013A>Tj /T1_0 1 Tf -0.021 Tw ( \023\030\024\007\024\035\032\017\021\034 )Tj 0 Tw -14.874 -1.218 Td (\027\026\002\035\033\007\036\027\017\036.)Tj 0.199 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-68( )]TJ EMC 1.056 0 Td (\213\f\035\017 \030\026\n\036\030)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (2 \f\n \017\035\017 \023\030\017\f\031\021\f\021\r\031\033\021 \f\017\n\023\ \021\024\n\t )Tj 0.518 Tw T* [(\(\002\024\035\034, )0.6(\017\027\r\026\020\017\027\026\006\017\016, )0.5(\024\002\f\021\030\031\022\006\017\016, )0.5(\022\030\024\r\024\021\036\004\036\027\017\036, )]TJ 0 Tw 0 -1.218 TD (\017\255\016\r\035\036\027\017\036\) )Tj /C2_0 1 Tf <013A>Tj /T1_0 1 Tf ( \023\036\030\036\005\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\036\n\031 \220\021\026\023\031.)Tj /T1_1 1 Tf 0.122 Tw -1.056 -2.436 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\200\004\f\001\212\004\003\002\006\b\013\r \003\r\217\003\013 \240\f\235\ \210\003\002\201\b\r\b\t\235 \216\004\006\004\220\003\r\006\004 )Tj 0 Tw -1.352 -1.218 Td (\002\206\006\004\213\002\004\b\t\235)Tj 0 -1.218 TD (\215\r\003\002\240\013:)Tj /T1_0 1 Tf 0.054 Tw T* (\226)Tj /Span<>> BDC [( )-213( )]TJ EMC 1.056 0 Td (\230\027\f\021\030\031\n\036\027\021\026\035\034\027\026\016 \253\023\026\ \035\034\023\026\006\017\016\273 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \002\017\024\023\f\ \017\005\027\t\b \013\017\023\006\024\r.)Tj /T1_1 1 Tf -1.056 -1.218 Td (\200\006\t\213\b\004\220\t:)Tj /T1_0 1 Tf 0.267 Tw T* (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.522 Tw 1.056 0 Td [(\255\t\214\212\003\002\214 )0.5(\212\002\240\210\230\220\t)]TJ /T1_0 1 Tf [(: )0.5(\235\024\030\n\017\030\024\r\026\027\017\036 )0.6(\031\020\035\031\002\035\036\027\017\016 )]TJ 0.294 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\036\030\b\027\024\f\021\017 \024\002\030\026\024\r\026\027\017\ \016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\027\026\007\026\r\035\017\r\026\027\017\017 )Tj -0.086 Tw T* (\(\f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 98%, \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 40%\).)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.085 Tw 1.056 0 Td (\255\t\214\212\003\002\214 \230\004\003\006\004)Tj /T1_0 1 Tf [(: \235\024\030\n\017\030\024\r\026\027\017\036 \021\030\036\031\020\024\035\ \034\027\024\005 )0.5(\253\023\026)]TJ 0 Tw (-)Tj 0.08 Tw T* [(\035\026\021\022\017/\001\026\021\030\026\273 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.268 0 Td [(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\027\026\007 )0.5(\023\024\r\036\030\b)]TJ 0 Tw (-)Tj -7.268 -1.218 Td (\027\024\f\021\034\033 \024\002\030\026\024\r\026\027\017\016 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\036\201 \021\030\026\022\006\017\017.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.138 Tw 1.056 0 Td (\255\t\214\212\003\002\214 \002\206\b\004\202\t\230\r\n\002\217\235 \202\ \t\006\004)Tj /T1_0 1 Tf (: \r\t\f\r\024\002\024\032\007\036\027\017\036 )Tj 0.237 Tw T* (\032\036\035\021\024\005 \032\017\030\024\r\024\005 \021\022\026\027\017\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \f\021\031\023\036\027)Tj 0 Tw (-)Tj 0.151 Tw T* (\004\026\021\024\005 \002\017\024\023\f\017\017 \(\n\024\032\036\021 \002\ \t\021\034 \030\036\026\035\017\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 )Tj 0 Tw T* (\027\036\024\002\b\024\007\017\n\024\f\021\017\).)Tj ET q 70.866 122.57 453.543 226.461 re W n q /GS0 gs 453.543294 0 0 226.531677 70.8661346 122.499573 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 111.7701 Tm (\022\t\217\210\b\002\220 11.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\200\027\026\020 \030\022\020\b\025\031\024\023\022\007\027\024\n\031\ \b\031 \020\f\b\031\032\022\023\026\020 \204\025\030\031\024\n\031\033\022\ \007\027\024\n\031\b\031 \022\024\024\f\027\030\031\021\020\025\022\t \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\020\n\023\022\n\022 \021\027\030\027\025\022\t \f\022\033\031\026 \234\ \202)Tj 0 -1.2 TD (\004\032\022\026\027\007\020\025\022\027: *)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\240\200\031\030\022\026\031\024\023\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf T* [(F)-16(igure 1)158.1(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Illustration of)Tj /Span<>> BDC ( )Tj EMC [(the diagnostic algor)-36.7(ithm for endoscopic e)-14.8(x)10(amination and manag)12(ement of)]TJ /Span<>> BDC ( )Tj EMC [(g)12(astrointestinal lipomas)]TJ T* [(N)17(o)13(te: *)]TJ /Span<>> BDC ( )Tj EMC [(\227 if necessar)-42.8(y)32(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.84 56.0378 Tm (176)Tj ET endstream endobj 105 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  z !"1Q3ARq#$Ca %&'()*2456789:BDEFGHIJSTUVWXYZbcdefghijrstuvwxyz u!1AQaq"25RTbsBS %3 #$&'()*46789:CDEFGHIJUVWXYZcdefghijrtuvwxyz?@mzP krn.U!ROT׸{o?Vô,ݙ2fR\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`U}9՝5M''j7j2oV6f?MXе@/7f~̥Yk i~Y3e/sXl*78*WIZ~f}.mm'B;ZWzu(uJ 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sғVnc9zd%))Xvmi:sQKS߭x1/3O[ݔlݞNXI`Z{1/3%J{Oȗ#'폖[o#(c;=Ե@ T)miiTVz&U}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}Zh핢Si8KXʬl 6ݧf)ENroDu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.K6&Yӫ6~Lcfv[5j%%fNPmrn-iO{=??W{~SvO|flodzݭz?g[>1k|^kiO{=??W{~SvO|flodzݭz?g[>1k|^kiO{=??W{~SvO|flodzݭz?g[>1k|^kiO{=??WsIJsnRmɻ[o endstream endobj 283 0 obj <>stream endstream endobj 102 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.09 Tw 10 0 0 10 42.5197 724.8299 Tm (\025\035\036\021\022\017 \001\r\026\027\027\024\n\t \220\022\f\023\030\036\ \f\f\017\030\031\033\021 \002\036\035\024\022 S-100, SD57, )Tj 0.131 Tw 0 -1.218 TD (SD56 \017)Tj /Span<>> BDC ( )Tj EMC [(GF)24(AP \(\020\035\017\026\035\034\027\t\005 \235\017\002\030\017\035\035\016\ \030\027\t\005 \022\017\f\035\t\005 \002\036)]TJ 0 Tw (-)Tj 0.016 Tw T* (\035\024\022\), \021\026\022\032\036 \007\035\016 \024\006\036\027\022\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\026 \023\030\024\035\017\235\036\030\026\021\017\ \r\027\024\005 )Tj 0.095 Tw T* (\026\022\021\017\r\027\024\f\021\017 \017\f\f\035\036\007\031\036\021\f\016\ Ki-67. \206\017\f\021\024\035\024\020\017\004\036\f\022\026\016 \022\026\ \030)Tj 0 Tw (-)Tj 0.036 Tw T* (\021\017\027\026 \001\r\026\027\027\024\n\t \023\030\036\007\f\021\026\r\ \035\016\036\021 \f\024\002\024\005 \r\036\030\036\021\036\027\024\022\035\ \036\021\024\004)Tj 0 Tw (-)Tj 0.07 Tw T* (\027\t\036 \024\023\031\b\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\017\004\027\t\b \f\035\031\004\026\016\b \f\024\f\021\024\016\ \013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b )Tj 0.219 Tw 0 -1.218 TD (\022\024\n\023\024\027\036\027\021\024\r: \023\035\024\021\027\024 \031\023\ \026\022\024\r\026\027\027\t\b \r\036\030\036\021\036\027\024\r\017\007\027\ \t\b )Tj 0.129 Tw 0 -1.218 TD (\001\r\026\027\027\024\r\f\022\017\b \022\035\036\021\024\022 \(\021\017\ \023\026 \202\027\021\024\027\017 \202\) \017)Tj /Span<>> BDC ( )Tj EMC (\030\t\b\035\t\b \024\027, )Tj 0.201 Tw T* (\002\024\020\026\021\t\b \020\017\f\021\017\024\006\017\021\026\n\017 \(\ \021\017\023 \202\027\021\024\027\017 \207\), \021\026\022\032\036 \n\024\ \020\031\021 )Tj 0.104 Tw T* (\235\024\030\n\017\030\024\r\026\021\034\f\016 \f\023\036\006\017\235\017\ \004\036\f\022\017\036 \f\021\030\031\022\021\031\030\t)Tj /Span<>> BDC ( )Tj EMC (\227 \021\036\035\034\006\026 )Tj 0 Tw T* (\200\036\030\024\022\026\017 [52].)Tj /T1_2 1 Tf 0.061 Tw T* [(\025\r\005\006\002\234\b\240\002\220\006\t\b\b\013\r )0.5(\002\212\210\216\002\f\t)]TJ /Span<>> BDC ( )Tj EMC /T1_1 1 Tf (\227 \020\036\021\036\030\024\020\036\027\027\026\016 \020\030\031\023)Tj 0 Tw (-)Tj -0.002 Tw 0 -1.218 TD (\023\026 \027\024\r\024\024\002\030\026\024\r\026\027\017\005, \r\f\021\ \030\036\004\026\033\013\026\016\f\016 \r\024 \r\f\036\b \024\030\020\026\ \027\026\b )Tj -0.024 Tw 0 -1.218 TD (\240\025\221, \023\030\024\017\f\b\024\007\016\013\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\220\027\007\024\022\030\017\027\027\t\b \022\035\036\ \021\024\022 \220\n)Tj 0 Tw (-)Tj 0 -1.218 TD (\002\030\017\024\027\026\035\034\027\024\005 \022\017\001\022\017 [45].)Tj 0.141 Tw T* (\215\030\017 \220\027\007\024\f\024\027\024\020\030\026\235\017\004\036\f\ \022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \203\233\210 \r\017\ \031)Tj 0 Tw (-)Tj 0.097 Tw T* (\026\035\017\017\030\031\033\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\027\017\006\036 \f\035\017\017\f\021\024\005 \024\002\024\035\ \024\004\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.106 Tw T* (\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \220\b\024\f\035\024\017\), \017\n\036\033\021 \020\024\n\024\020\036\027\ \027\031\033 )Tj 0.122 Tw T* (\f\021\030\031\022\021\031\030\031, \004\036\021\022\017\036 \020\035\026\ \007\022\017\036 \022\024\027\021\031\030\t, \f\030\036\007\027\036\023\024\ \027\017\032\036\027)Tj 0 Tw (-)Tj T* (\027\031\033 \220\b\024\020\036\027\027\024\f\021\034 \017\035\017 \017\ \024\220\b\024\020\036\027\027\024\f\021\034 [26].)Tj 0.168 Tw T* (\233\211\222 \017\020\030\026\036\021 \r\026\032\027\031\033 \030\024\035\ \034 \r)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\020\027\024\f\021\017\022\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 )Tj 0.534 Tw T* [(\027\026\035\017\004\017\016 )0.6(\023\024\030\026\032\036\027\017\016 )0.5(\030\036\020\017\024\027\026\030\027\t\b )0.5(\035\017\n\235\026\021\017\004\036\f\022\017\b )]TJ 0.025 Tw T* (\031\035\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\017\016 \020\017\f\021\024\035\024\020\017\004\ \036\f\022\024\020\024 \n\026\021\036\030\017\026\035\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj -0.007 Tw T* (\n\024\013\034\033 \233\211\222-\221\230\215. \212\017\026\020\027\024\f\ \021\017\004\036\f\022\026\016 \021\024\004\027\024\f\021\034 \233\211\222\ \026\r\017)Tj 0 Tw (-)Tj 0.069 Tw T* (\f\017\021 \024\021 \030\026\n\036\030\026 \027\024\r\024\024\002\030\026\ \024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \035\024\022\026\035\017\026\006\017\017, )Tj 0.297 Tw T* [(\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )0.6(\n\036\021\024\007\026 )0.5(\r\026\030\034\017\030\031\036\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.887 0 Td [(\023\030\036\007\036\035\026\b )0.6(\024\021 )]TJ 0.068 Tw -16.887 -1.218 Td (40 \007\024)Tj /Span<>> BDC ( )Tj EMC (90% [46]. \210\007\027\026\022\024 \023\024\f\022\024\035\034\022\031 \021\ \024\004\027\024\f\021\034 \035\031\004\036\r\t\b )Tj 0.163 Tw T* (\n\036\021\024\007\024\r \r\017\031\026\035\017\026\006\017\017, \021\026\ \022\017\b \022\026\022 \025\221, \204\217\221 \017)Tj /Span<>> BDC ( )Tj EMC (\215\233\221/\025\221 )Tj 0.085 Tw T* [(\021\026\022\032\036 )0.5(\024\020\030\026\027\017\004\036\027\026, )0.6(\233\211\222 )0.5(\024\f\021\026\036\021\f\016 )0.5(\023\030\017\024\030\017\021\036\021\027\t\n )0.6(\007\017\026\020)]TJ 0 Tw (-)Tj 0.365 Tw T* (\027\024\f\021\017\004\036\f\022\017\n \f\023\024\f\024\002\024\n \024\006\ \036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \203\233\210. )Tj 0.241 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\022\024\030\024\f\021\017 \ \023\030\024\035\017\235\036\030\026\006\017\017 \007\036\035\016\021\f\016\ )Tj 0.174 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.38 0 Td [(3 )0.5(\020\030\031\023\023\t: )0.5(G1, )0.6(G2 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.54 0 Td [(G3. )0.5(\212\035\016 \r\t\016\r\035\036\027\017\016 )0.6(\035\024\022\026\004\036)]TJ 0 Tw (-)Tj 0.209 Tw -9.921 -1.218 Td (\f\021\r\036\027\027\024\020\024 \023\024\021\036\027\006\017\026\035\026\ \024\023\030\036\007\036\035\016\036\021\f\016 \004\017\f\035\024 \n\017\ \021\024\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\036\022\f Ki-67.)Tj /T1_2 1 Tf 0.542 Tw T* (\026\002\217\212\004\f\t\003\r\f\001\b\013\005 \226\t\206\006\002\213\b\013\ \005 \212\002\f\t\212 \(\026\203\200\))Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (\227 )Tj 0.601 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\036, \f\024\f\021\024\016\ \013\036\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\036\021\036\027\024\r\017\007\027\t\b )Tj 0.192 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \022\035\036\021\024\022\ , \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\036\035\022\017\b \f\024\f\031\007\024\r. )Tj 0.497 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\n \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.054 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \023\024\ \035\017\023\024\r\017\007\027\024\036 \027\024\r\024\024\002\030\026\024\ \r\026\027\017\036 )Tj 0.352 Tw T* [(\023\035\024\021\027\024\220\035\026\f\021\017\004\036\f\022\024\005 )0.6(\022\024\027\f\017\f\021\036\027\006\017\017. )0.6(\210\f\027\024\r\027\t\036 )0.6(\233\211\222-)]TJ 0 Tw T* (\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \200\205\215:)Tj -0.006 Tw T* (\251)Tj /Span<>> BDC [( )-273( )]TJ EMC 1 0 Td [(\020\017\023\024\220\b\024\020\036\027\027\024\036 )0.6(\024\002\030\026\024\r\026\027\017\036 )0.6(\024\007\027\024\030\024\007\027\024\005 )0.5(\220\b\024\f\021\030\031\022)]TJ 0 Tw (-)Tj T* (\021\031\030\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\201\021\022\017\n\017 \022\024\027\021\031\030\026\n\017;)Tj 0.211 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-56( )]TJ EMC 1 0 Td (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.062 Tw T* (\035\024\004\022\017 \(2 \220\b\024\f\035\024\005\) \017\035\017 \023\024\ \007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024)Tj /Span<>> BDC (-)Tj EMC 0 Tw T* (\f\035\024\005\) [26, 47].)Tj -0.022 Tw -1 -1.218 Td (\203\024\r\024\024\002\030\026\024\r\026\027\017\036 \f\024\f\021\024\017\ \021 \017)Tj /Span<>> BDC ( )Tj EMC 12.145 0 Td [(\r\036\030\036\021\036\027\024\r\017\007\027\t\b )0.5(\022\035\036\021\024\022, )]TJ -0.009 Tw -12.145 -1.218 Td [(\n\036\035\022\017\b )0.5(\f\024\f\031\007\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.412 0 Td [(\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.5(\022\035\036\021\024\022 )0.5(\(\220\024\017\027\024\235\017)]TJ 0 Tw (-)Tj -7.412 -1.218 Td (\035\t, \035\017\n\235\024\006\017\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\026\021\017\004\036\f\022\017\036 \022\035\036\021\022\017\ \) [27].)Tj /T1_2 1 Tf 0.034 Tw T* [(\032\206\r\006\006\004\b\003\b\004\235 )0.6(\212\002\240\202\r\f\210\240\002\201\b\004\235 )0.6(\202\r\f\r\213\004 )0.5(\(\032\200\207\))]TJ /T1_1 1 Tf /Span<>> BDC ( )Tj EMC [(\227 )0.5(\020\036)]TJ 0 Tw (-)Tj -0.051 Tw T* (\021\036\030\024\021\024\023\017\016 \023\026\027\022\030\036\026\021\017\ \004\036\f\022\024\005 \021\022\026\027\017 \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\t \024\030\021\024\021\024)Tj 0 Tw (-)Tj -0.015 Tw T* (\023\017\004\036\f\022\024\005 \023\024\007\032\036\035\031\007\024\004\027\ \024\005 \032\036\035\036\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \030\026\024\002\013\036)Tj 0 Tw (-)Tj 0.116 Tw T* (\027\017\036\n \017\b \022\030\024\r\024\f\027\026\002\032\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\027\036\030\r\026\006\017\017 \(\f\017\027\024\027\017\n\t: )Tj 0.002 Tw T* (\007\024\002\026\r\024\004\027\026\016 \023\024\007\032\036\035\031\007\024\ \004\027\026\016 \032\036\035\036\026, \b\024\030\017\f\021\024\n\026\)\ [48]. )Tj 0.497 Tw 23.244 64.543 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\n \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.294 Tw T* [(\023\030\036\007\f\021\026\r\035\016\036\021 )0.5(\f\024\002\024\005 \023\024\035\031\f\235\036\030\017\004\036\f\022\024\036\ \017\035\017 )0.5(\022\024\027\031\f\024)]TJ 0 Tw (-)Tj -0.008 Tw T* (\r\017\007\027\024\036 \027\024\r\024\024\002\030\026\024\r\026\027\017\ \036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\021\016\032\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\026\035\034\027\024\005 )Tj 0.381 Tw T* (\004\026\f\021\017, \022\024\021\024\030\024\036 \f\024\024\021\r\036\021\ \f\021\r\031\036\021 \r\t\r\024\007\027\024\n\031 \023\030\024\021\024\022\ \031. )Tj 0 Tw T* (\210\f\027\024\r\027\t\036 \233\211\222-\b\026\030\026\022\021\036\030\017\ \f\021\017\022\017 \202\215\240 [49]:)Tj -0.032 Tw T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\020\036\021\036\030\024\020\036\027\027\024\036 \024\002\030\026\024\r\ \026\027\017\036 \020\017\023\024\220\b\024\020\036\027\027\024\005 \017\ \035\017 \017\024)Tj 0 Tw (-)Tj 0.354 Tw -1 -1.218 Td (\220\b\024\020\036\027\027\024\005 \f\021\030\031\022\021\031\030\t \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\017\n\017 \020\017\023\036\030\220\b\024\020\036\027\027\t\ \n\017 )Tj 0 Tw T* (\r\022\035\033\004\036\027\017\016\n\017 \(\023\024 \021\017\023\031 \253\ \f\024\035\034\226\023\036\030\036\006\273\);)Tj 0.428 Tw T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\024\023\030\036\007\036\035\016\036\021\f\016 \023\030\024\021\024\022\024\ \r\026\016 \f\021\030\031\022\021\031\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\201\021\022\017)Tj 0 Tw (-)Tj 0.462 Tw -1 -1.218 Td [(\n\017 )0.5(\022\024\027\021\031\030\026\n\017. )0.6(\210\002\030\026\024\r\026\027\017\036 )0.6(\017\f\b\024\007\017\021 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.832 0 Td (\023\024\007\f\035\017)Tj 0 Tw (-)Tj 0.229 Tw -18.832 -1.218 Td (\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024\f\035\024\005\) \017\ \035\017 \n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 )Tj 0 Tw T* (\(4)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005\).)Tj 0.453 Tw 0 -1.218 TD (\203\036\017\027\r\026\017\r\027\t\036 \017\f\f\035\036\007\024\r\026\027\ \017\016 \r\017\031\026\035\017\026\006\017\017, \021\026\022\017\036 \ )Tj 0.098 Tw 0 -1.218 TD (\022\026\022 \025\221 \017)Tj /Span<>> BDC ( )Tj EMC (\204\217\221, \n\024\020\031\021 \023\024\022\026\026\021\034 \027\036\f\ \023\036\006\017\235\017\004\036\f\022\024\036 \031\f\017)Tj 0 Tw (-)Tj 0.24 Tw 0 -1.218 TD (\035\017\r\026\033\013\036\036\f\016 \031\021\024\035\013\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \017\035\017 \022\017\001\036\004\027\017\022\ \036, )Tj 0.258 Tw T* (\027\024 \027\036 \023\024\r\024\035\016\033\021 \024\022\024\027\004\026\ \021\036\035\034\027\024 \007\017\235\235\036\030\036\027\006\017\030\024\ \r\026\021\034 )Tj 0.087 Tw T* (\024\002\030\026\024\r\026\027\017\036, \233\211\222 \023\024\r\024\035\ \016\036\021 \024\023\030\036\007\036\035\017\021\034 \023\030\024\021\024\ \022\024\r\031\033 )Tj 0.287 Tw T* (\f\017\f\021\036\n\031)Tj /Span<>> BDC ( )Tj EMC (\227 \f\023\036\006\017\235\017\004\027\t\005 \023\030\017\027\026\022.\ \210\022\024\027\004\026\021\036\035\034\027\t\005 )Tj 0.04 Tw T* (\007\017\026\020\027\024 \r\036\030\017\235\017\006\017\030\031\036\021\ \f\016 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \020\017\f\021\024\035\024)Tj 0 Tw (-)Tj -0.012 Tw T* (\020\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016, \007\035\016 \023\024\035\031\004\036\027\017\016 \002\017\024\023\ \f\017\005\027\024\020\024 )Tj 0 Tw T* (\n\026\021\036\030\017\026\035\026 \r\024\n\024\032\027\024 \023\030\017\ \n\036\027\036\027\017\036 \233\211\222-\221\230\215 [50].)Tj /T1_2 1 Tf 0.601 Tw T* (\033\r\006\b\t\217\003\002-\220\f\r\003\002\201\b\004\235 \002\212\210\216\ \002\f\001 \(\033\021\017\), \t\f\t \002\212\210)Tj 0 Tw (-)Tj 0.236 Tw T* (\216\002\f\001 \032\206\006\t\220\002\217\002\004)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (\227 \024\021\027\024\f\017\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\n\031\030\026\035\034\027\t\n )Tj 0.432 Tw T* (\(\n\036\036\027\b\017\n\026\035\034\027\t\n\) \027\024\r\024\024\002\030\ \026\024\r\026\027\017\016\n \017)Tj /Span<>> BDC ( )Tj EMC (\022 \020\030\031\023\023\036 )Tj 0.422 Tw T* [(\030\036\007\022\017\b )0.5(\024\023\031\b\024\035\036\005 )0.6(\027\036\016\f\027\024\020\024 )0.5(\017\035\017 )0.6(\f\023\024\030\027\024\020\024 )0.5(\020\036\027\036\026. )]TJ 0.243 Tw T* (\215\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \027\036\ \002\024\035\034\001\024\036 \031\035\024\r\024\036 \027\024\r\024\024\002\ \030\026)Tj 0 Tw (-)Tj -0.011 Tw T* (\024\r\026\027\017\036 \002\035\036\007\027\024-\032\036\035\021\024\020\ \024 \006\r\036\021\026, \023\024\022\030\t\021\024\036 \027\036\017\n\036\ \027\036\027)Tj 0 Tw (-)Tj T* (\027\024\005 \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\024\ \005. \233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \ [51]:)Tj 0.198 Tw T* (\251)Tj /Span<>> BDC [( )-69( )]TJ EMC 1 0 Td (\020\036\021\036\030\024\020\036\027\027\026\016 \020\017\023\024\220\b\024\ \020\036\027\027\026\016 \f\021\030\031\022\021\031\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 )Tj 0 Tw T* (\022\024\027\021\031\030\026\n\017;)Tj 0.786 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )519( )]TJ EMC 1 0 Td (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 )Tj 0.401 Tw T* (\024\002\024\035\024\004\022\017 \(2 \220\b\024\f\035\024\005\) \017\035\ \017 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 )Tj 0 Tw T* (\(3)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005\).)Tj 0.063 Tw -1 -1.218 Td (\200\t\023\024\035\027\036\027\017\036 \233\211\222 \024\002\t\004\027\024\ \016\r\035\016\036\021\f\016 \f\035\036\007\031\033\013\017\n \001\026\020\ \024\n )Tj 0.045 Tw T* (\023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 \233\206\212\222\ , \007\035\016 \023\030\036\007\f\021\026\r\035\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024)Tj 0 Tw (-)Tj 0.226 Tw T* (\035\024\032\036\027\017\017 \024\002\030\026\024\r\026\027\017\016 \024\ \021\027\024\f\017\021\036\035\034\027\024 \f\035\024\036\r \024\030\020\ \026\027\024\r )Tj -0.018 Tw T* (\240\025\221, \021\026\022\032\036 \r\024\n\024\032\027\024 \r\t\023\024\ \035\027\036\027\017\036 \233\211\222-\221\230\215 \007\035\016 \023\024\ \035\031)Tj 0 Tw (-)Tj 0.037 Tw T* (\004\036\027\017\016 \002\017\024\023\f\017\005\027\024\020\024 \n\026\021\ \036\030\017\026\035\026 [51]. \216\026\030\026\022\021\036\030\027\026\016\ \n\017)Tj 0 Tw (-)Tj -0.039 Tw T* (\022\030\024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \003\025\210 \f\024\f\021\024\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\t\b )Tj 0.103 Tw T* (\020\027\036\007, \035\036\027\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\031\004\022\024\r \022\030\031\023\027\t\b \022\035\036\021\024\022\ \n\027\024\020\024\031\020\024\035\034\027\024\005 )Tj 0.354 Tw T* (\235\024\030\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\024\016\004\036\017\f\021\024\005 \026\006\017\007\024\235\ \017\035\034\027\024\005 \006\017\021\024\023\035\026)Tj 0 Tw (-)Tj 0.084 Tw T* (\n\024\005, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \r\f\021\030\036\004\026\033\021\f\016 \n\027\ \024\020\024\004\017\f\035\036\027\027\t\036 \026\006\017\007\024)Tj 0 Tw (-)Tj -0.008 Tw T* [(\235\017\035\034\027\t\036 )0.6(\036\030\027\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.254 0 Td [(\020\035\t\002\022\017 )0.5([52]. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.276 0 Td [(\230\206\216 )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )]TJ -0.007 Tw -14.531 -1.218 Td [(\n\026\030\022\036\030\026\n\017 )0.5(\024\023\031\b\024\035\017 )0.6(\202\002\030\017\022\024\f\024\r\026 )0.5(\016\r\035\016\033\021\f\016 )0.6(\n\026\030\022\036\030 )0.5(\r\017)]TJ 0 Tw (-)Tj 0.116 Tw T* (\n\036\027\021\017\027, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \002\036\035\022\017 S100, CD68, NSE, CD56 \017)Tj /Span<>> BDC ( )Tj EMC (EMA, )Tj 0.017 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\035\016 \024\023\030\036\007\036\035\036\027\017\ \016 \035\024\022\026\004\036\f\021\r\036\027\027\024\020\024 \023\024\021\ \036\027\006\017)Tj 0 Tw (-)Tj T* (\026\035\026 \024\023\030\036\007\036\035\016\036\021\f\016 \004\017\f\035\ \024 \n\017\021\024\024\r, \017\027\007\036\022\f Ki-67 [53].)Tj /T1_2 1 Tf 0.002 Tc 0.799 Tw T* [(\031\210\212\f\t\220\004\204\t\002\b\b\013\r )0.5(\220\t\217\003\013. )]TJ /T1_1 1 Tf 12.624 0 Td [(\212\031\023\035\017\022\026\006\017\024\027\027\t\036 )0.5(\022\017)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.302 Tw -12.624 -1.218 Td (\f\021\t \240\025\221 \004\026\013\036 \r\f\036\020\024 \r\f\021\030\036\ \004\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\r\007\024\001\027\024\005)2( )]TJ 0.326 Tw T* (\022\017\001\022\036, \023\017\013\036\r\024\007\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 [54]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.326 Tw T* (\007\024\f\022\024\023\017\004\036\f\022\024\n \024\f\n\024\021\030\036 \ \024\002\t\004\027\024 \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.345 Tw T* (\002\024\005 \007\036\235\024\030\n\026\006\017\033 \f\021\036\027\022\017\ \017\035\017 \021\024\027\022\024\f\021\036\027\027\024\036 \027\024\r\024\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.201 Tw T* [(\024\002\030\026\024\r\026\027\017\036, )0.5(\f\035\017\017\f\021\026\016 )0.5(\027\026\007 )0.5(\022\024\021\024\030\t\n )0.6(\027\036 )0.5(\017\n\036\027\036\027\026.)2( )]TJ -0.002 Tw T* (\233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\017:)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_3 1 Tf 25 0 0 25 505.5021 56.0378 Tm (175)Tj ET endstream endobj 100 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.158 Tw 10 0 0 10 70.8661 396.0239 Tm (\027\026\017\002\024\035\036\036 \f\023\036\006\017\235\017\004\027\t\n.\ \221\026\022\032\036 \023\030\024\r\024\007\017\021\f\016 \n\024\035\036\ \022\031)Tj 0 Tw (-)Tj 0.239 Tw 0 -1.218 TD (\035\016\030\027\024-\020\036\027\036\021\017\004\036\f\022\024\036 \017\ \f\f\035\036\007\024\r\026\027\017\036 \n\031\021\026\006\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj 0 Tw T* (KIT \017)Tj /Span<>> BDC ( )Tj EMC (PDGFR\202)Tj /Span<>> BDC ( )Tj EMC ([36].)Tj /T1_1 1 Tf T* (\035\r\005\002\214\t\002\214\004)Tj /T1_0 1 Tf 0.326 Tw ( \016\r\035\016\036\021\f\016 \017\f\021\017\027\027\t\n \n\t\001\036\004\ \027\t\n \017\027\021\030\026)Tj 0 Tw (-)Tj 1.154 Tw T* (\n\031\030\026\035\034\027\t\n \027\024\r\024\024\002\030\026\024\r\026\ \027\017\036\n, \030\026\r\017\r\026\033\013\017\n\f\016 )Tj 0.309 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\026\007\022\024\n\t\001\036\004\027\t\b \022\035\036\021\024\022\ , \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \035\024)Tj 0 Tw (-)Tj 0.312 Tw T* (\022\026\035\017\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\017\013\036\r\024\007\036. \003\035\024\022\026\004\036\f\021\r\036\ \027\027\t\005 )0.5(\r\026\030\017\026\027\021 )]TJ 0.03 Tw T* (\035\036\005\024\n\017\024\n\t)Tj /Span<>> BDC ( )Tj EMC (\227 \035\036\005\024\n\017\024\f\026\030\022\024\n\026, \027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\240\025\221 \024\027\026 \r\f\021\030\036)Tj 0 Tw (-)Tj 0.218 Tw T* (\004\026\036\021\f\016 \004\030\036\r\t\004\026\005\027\024 \030\036\007\ \022\024 \017,)Tj /Span<>> BDC ( )Tj EMC (\022\026\022 \023\030\026\r\017\035\024, \007\017\235\235\036)Tj 0 Tw (-)Tj 0.233 Tw T* (\030\036\027\006\017\026\035\034\027\026\016 \007\017\026\020\027\024\f\021\ \017\022\026 \023\030\024\r\024\007\017\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210 [38]. )Tj 0 Tw T* (\210\f\027\024\r\027\t\036 \233\211\222-\b\026\030\026\022\021\036\030\017\ \f\021\017\022\017 \035\036\005\024\n\017\024\n\t:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\004\036\021\022\017\036 \022\024\027\021\031\030\t;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\020\024\n\024\020\036\027\027\026\016 \020\017\023\024\220\b\024\020\036\ \027\027\026\016 \f\021\030\031\022\021\031\030\026;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\n\024\032\036\021 \002\t\021\034 \n\027\024\020\024\022\026\n\036\030\027\ \024\005.)Tj -0.035 Tw -1 -1.218 Td (\210\002\030\026\024\r\026\027\017\036 \017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 \(4)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f)Tj 0 Tw (-)Tj 0.29 Tw T* (\035\024\005\) \017\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.302 Tw T* (\035\024\004\022\017 \(2)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005\). \203\036\030\024\r\027\t\036 \022\030\026\016\ , \027\036\024\007\027\024\030\024\007\027\026\016 )Tj 0.087 Tw T* [(\220\b\024\020\036\027\027\024\f\021\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\220\b\024\020\036\027\027\t\n\017 )0.5(\r\022\035\033\004\036\027\017\016\n\017, \031\r\036\035\017\004\036)]TJ 0 Tw (-)Tj 0.094 Tw T* (\027\017\036 \030\036\020\017\024\027\026\035\034\027\t\b \035\017\n\235\ \026\021\017\004\036\f\022\017\b \031\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\017 \233\211\222-)Tj -0.045 Tw T* (\023\030\017\027\026\022\017 \n\024\020\031\021 \031\022\026\t\r\026\021\ \034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\004\036\f\021\r\036\027\027\t\005 \b\026\030\026\022)Tj 0 Tw (-)Tj T* (\021\036\030 \027\024\r\024\024\002\030\026\024\r\026\027\017\016.)Tj 0.092 Tw T* (\212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \021\024\004\027\ \024\f\021\034 \233\211\222 \n\024\032\036\021 \007\024\f\021\017\020\026\ \021\034 \024\022\024)Tj 0 Tw (-)Tj 0.079 Tw T* (\035\024 86\22688% [45]. \210\007\027\026\022\024 \027\036 \f\031\013\036\ \f\021\r\031\036\021 \f\023\036\006\017\235\017\004\036\f)Tj 0 Tw (-)Tj 0.454 Tw T* (\022\017\b \233\211\222-\022\030\017\021\036\030\017\036\r \007\035\016 \ \007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 \007\017\ \026\020)Tj 0 Tw (-)Tj 0.186 Tw T* (\027\024\f\021\017\022\017 \017\027\021\030\026\n\031\030\026\035\034\027\ \t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \024\030\020\026\ \027\024\r )Tj 0.163 Tw T* (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ , \021\024\004)Tj 0 Tw (-)Tj 0.262 Tw T* [(\027\024\f\021\034 )0.5(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\023\024\r\t\001\026\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.918 0 Td [(\f\024\004\036\021\026\027\017\017 )0.6(\233\211\222 )]TJ -0.047 Tw 7.326 31.663 Td (\f)Tj /Span<>> BDC ( )Tj EMC [(\021\024\027\022\024\017\020\024\035\034\027\024\005 )0.5(\023\031\027\022\006\017\036\005 )0.5(\(\221\230\215\) \f)]TJ /Span<>> BDC ( )Tj EMC 14.343 0 Td [(\023\024\f\035\036\007\031\033\013\036\005 )0.5(\n\024\030)]TJ 0 Tw (-)Tj 0.17 Tw -14.343 -1.218 Td (\235\024\035\024\020\017\004\036\f\022\024\005 \r\036\030\017\235\017\022\ \026\006\017\036\005)Tj /Span<>> BDC ( )Tj EMC ([39]. \206\017\f\021\024\035\024\020\017\004\036\f\022\026\016 )Tj 0.107 Tw T* [(\r\036\030\017\235\017\022\026\006\017\016 )0.6(\035\036\005\024\n\017\024\n )0.5(\027\036 )0.5(\r\t\t\r\026\036\021 )0.5(\021\030\031\007\027\024\f\021\036\005, )0.6(\027\024 )]TJ 0.25 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \r\f\036\020\007\026 \023\030\024\r\024\007\ \016\021 \230\206\216-)Tj 0.354 Tw T* (\235\036\027\024\021\017\023\017\030\024\r\026\027\017\036 \007\035\016 \ \017\f\022\035\033\004\036\027\017\016 \206\230\222\210. \210\023\031\b\024\ \035\017 )Tj -0.05 Tw T* (\016\030\022\024 \220\022\f\023\030\036\f\f\017\030\031\033\021 \007\036\ \f\n\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\026\007\022\024\n\t\001\036\004\027\t\005 \026\022\021\017\027 \ )Tj 0.447 Tw T* [(\(SM-\026\022\021\017\027\). )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.831 0 Td [(\035\024\022\026\004\036\f\021\r\036\027\027\024\005 )0.5(\021\030\026\027\f\235\024\030\n\026\006\017\017 )]TJ 0.271 Tw -7.831 -1.218 Td (\035\036\005\024\n\017\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\005\024\n\017\024\f\026\030\022\024\n\031)Tj /Span<>> BDC ( )Tj EMC (\227 \n\024\030\235\024\035\024\020\017\004\036\f\022\017 )Tj 0.226 Tw T* (\r\t\016\r\035\016\036\021\f\016 \r\t\f\024\022\017\005 \n\017\021\024\021\ \017\004\036\f\022\017\005 \017\027\007\036\022\f \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026)Tj 0 Tw (-)Tj T* (\032\036\027\027\t\005 \022\035\036\021\024\004\027\t\005 \023\024\035\017\ \n\024\030\235\017\n)Tj /Span<>> BDC ( )Tj EMC ([40].)Tj /T1_1 1 Tf T* (\016\004\b\b\002\214\004)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 0.132 Tw 4.923 0 Td (\227 \030\036\007\022\026\016 \017\027\021\030\026\n\031\030\026\035\034\ \027\026\016 \024\023\031\b\024\035\034 \027\036\005)Tj 0 Tw (-)Tj -0.04 Tw -4.923 -1.218 Td (\030\024\020\036\027\027\024\020\024 \023\030\024\017\f\b\024\032\007\036\ \027\017\016, \030\026\r\017\r\026\033\013\026\016\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\n\n\024)Tj 0 Tw (-)Tj 0.056 Tw T* (\006\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \022\035\036\021\024\022, \024\002\030\026\031\033\013\017\b \f\024\ \002\f\021\r\036\027\027\031\033 \024\002\024\035\024\004\022\031 )Tj 0.175 Tw T* [(\026\022\f\024\027\026. )0.5(\203\026\017\002\024\035\036\036 )0.6(\004\026\f\021\024 )0.5(\007\026\027\027\t\005 )0.5(\021\017\023 )0.5(\027\024\r\024\024\002\030\026\024\r\026)]TJ 0 Tw (-)Tj 0.115 Tw T* (\027\017\005 \024\002\027\026\030\031\032\017\r\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036, \023\017\013\036\r\024\007\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\n )Tj 0 Tw T* (\f\030\036\007\024\f\021\036\027\017\017)Tj /Span<>> BDC ( )Tj EMC ([41].)Tj 0.503 Tw T* (\215\024 \233\211\222-\022\026\030\021\017\027\036 \001\r\026\027\027\024\ \n\026 \f\b\024\032\026 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\005\024\n\017\024\n\024\005 )Tj 0.429 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210)Tj /Span<>> BDC ( )Tj EMC (\227 \004\026\013\036 \r\f\036\020\024 \030\026\f\023\024\035\026\020\026\ \036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004)Tj 0 Tw (-)Tj 0.457 Tw T* (\027\024\n \(4 \220\b\024\f\035\024\005\) \017\035\017 \023\024\007\f\035\ \017\017\f\021\024\n \(3 \220\b\024\f\035\024\005\) )Tj 0.799 Tw T* [(\f\035\024\036. )0.5(\212\017\235\235\036\030\036\027\006\017\026\035\034\027\026\016 )0.5(\007\017\026\020\027\024\f\021\017\022\026 )0.5(\r\024\n\024\032)]TJ 0 Tw (-)Tj 0.374 Tw T* (\027\026 \021\024\035\034\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \020\017\f\021\024\035\024\020\017\004\036\ \f\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\230\206\216 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([42].)Tj 0.487 Tw T* (\212\035\016 \023\024\035\031\004\036\027\017\016 \020\017\f\021\024\035\ \024\020\017\004\036\f\022\024\020\024 \n\026\021\036\030\017\026\035\026\ \r\024)Tj 0 Tw (-)Tj 0.269 Tw T* (\n\024\032\027\024 \r\t\023\024\035\027\036\027\017\036 \233\211\222-\221\ \230\215, \007\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \021\024\ \004)Tj 0 Tw (-)Tj 0.211 Tw T* [(\027\024\f\021\034 )0.6(\022\024\021\024\030\024\020\024 )0.5(\f\024\f\021\026\r\035\016\036\021 )0.6(\024\021 )0.5(50 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 16.002 0 Td [(85,2% )0.5([43,44]. )]TJ 0.013 Tw -16.002 -1.218 Td (\210\022\024\027\004\026\021\036\035\034\027\026\016 \n\024\030\235\024\035\ \024\020\017\004\036\f\022\026\016 \021\030\026\022\021\024\r\022\026 \007\ \017\026\020\027\024\026 )Tj 0.028 Tw T* (\r\024\n\024\032\027\026 \002\035\026\020\024\007\026\030\016 \023\030\024\ \r\036\007\036\027\017\033 \230\206\216 \017\f\f\035\036\007\024\r\026\027\ \017\016. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 70.8661 730.4829 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \220\022\203\203\027\032\027\025\006\022\020\f\017\025\020\t \030\022\020\ \b\025\031\024\023\022\n\020 \022\025\032\020\026\r\032\020\f\017\025\013\ \200 \025\031\021\031\031\240\032\020\016\031\021)0.5(\020\025\022\235 \031\032\b\020\025\031\021 \255\027\f\r\030\031\007\025\ \031-\n\022\213\027\007\025\031\b\031 \023\032\020\n\023\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)5.1(f)-42.3(f)-13.4(e)-6(r)-2(e)-7(n)-0.6(t)-29.1(i)1.5(a)-4.5(l d)-2.9(i)1.5(a)-5.2(g)-2.4(n)-2.4(o)-1.1(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(i)3.9(n)-0.6(t)-9.6(r)3.3(a)-5.1(m)1(u)1.6(r)3.3(a)-4.5(l n)-2.4(e)-10.4(o)-5.3(p)-4.9(l)-1.1(a)-7.1(s)5.1(m)3.2(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e g)-3.9(a)-7.2(s)-14.8(t)-9.6(r)-2(o)0.9(i)3.9(n)-0.6(t)-1.6(e)-22(s)-14.8(t)-29.1(i)4(na)-4.5(l t)-9.6(r)3.3(a)-9.2(c)-32.4(t)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.1809 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 153.3209 715.1809 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 212.8484 715.1809 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 715.1809 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 715.1809 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 436.7854 715.1809 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1117 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 153.3209 694.1117 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 212.8484 694.1117 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 246.8642 694.1117 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 694.1117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 436.7854 694.1117 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 673.0504 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 153.3209 673.0504 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 673.0504 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 246.8642 673.0504 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 337.5728 673.0504 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 436.7854 673.0504 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 632.7891 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 153.3209 632.7891 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 632.7891 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 246.8642 632.7891 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 337.5728 632.7891 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 436.7854 632.7891 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 592.5278 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 153.3209 592.5278 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 592.5278 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 246.8642 592.5278 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 337.5728 592.5278 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 436.7854 592.5278 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 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cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 337.5728 531.2053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 436.7854 531.2053 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 500.544 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 153.3209 500.544 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 500.544 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 246.8642 500.544 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 337.5728 500.544 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 436.7854 500.544 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 469.8827 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 153.3209 469.8827 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 469.8827 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 246.8642 469.8827 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 337.5728 469.8827 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 436.7854 469.8827 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 429.6214 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 153.3209 429.6214 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 212.8484 429.6214 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 246.8642 429.6214 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 337.5728 429.6214 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 436.7854 429.6214 cm 0 0 m 88.124 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 90.8228 701.7463 Tm (\020\t\212 \002\212\210\216\002\f\t)Tj 9.453 0.6 Td (\017\206\002\f\002\201\220\004 )Tj 0.607 -1.2 Td (\217\003\r\b\220\t)Tj 6.395 1.2 Td (\231\216\002-)Tj -0.099 -1.2 Td (\217\f\002\005)Tj 5.763 0.6 Td (\231\216\002-\217\003\006\210\220\003\210\006\004)Tj 11.248 0.6 Td (\027\t\217\003\002\f\002\n\t\201\r\217\220\002\r)Tj 1.654 -1.2 Td (\255\003\006\002\r\b\t\r)Tj 9.661 0.6 Td (\034\027\225-\t\217\217\f\r\240\002\004\b\t\r)Tj /T1_0 1 Tf -46.791 -2.033 Td (\214\017\023\024\n\026)Tj 10.83 0 Td (\023\024\007\f\035\017\017\f\021\026\016 )Tj 8.408 0 Td (3)Tj 4.775 0 Td (\020\017\023\036\030\220\b\024\020\036\027\027\026\016)Tj 10.519 0 Td (\030\036\035\026\016 \002\036\035\026\016 \032\017\030\024\r\026\016 )Tj 3.493 -1.2 Td (\021\022\026\027\034)Tj 10.187 1.2 Td (\027\036 \021\030\036\002\031\036\021\f\016)Tj -48.213 -2.633 Td (\206\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\026\ \016 )Tj T* (\f\021\030\024\n\026\035\034\027\026\016 \024\023\031\b\024\035\034)Tj 11.522 1.2 Td (\n\t\001\036\004\027\026\016 )Tj 7.257 0 Td (2, 4 )Tj 3.325 0 Td (\020\017\023\024\220\b\024\020\036\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 )Tj 3.004 -1.2 Td (\022\024\027\021\031\030\026\n\017)Tj 8.538 1.2 Td (\r\036\030\036\021\036\027\024\r\017\007\027\024-\022\035\036\021\024\004\ \027\t\005 )Tj 4.808 -1.2 Td (\021\017\023)Tj -4.589 -1.2 Td (\220\023\017\021\036\035\017\024\017\007\027\024-\022\035\036\021\024\004\ \027\t\005 )Tj 4.589 -1.2 Td (\021\017\023)Tj 9.486 3.6 Td (\221\030\036\002\031\036\021\f\016 \007\035\016 )Tj -1.746 -1.2 Td (\r\t\016\r\035\036\027\017\016 \021\026\030\020\036\030\021\027\024\005 \ )Tj -0.228 -1.2 Td (\n\031\021\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016 )Tj 1.486 -1.2 Td (\020\030\031\023\023\026 \023\030\024\020\027\024\026)Tj -47.452 -1.433 Td (\214\036\005\024\n\017\024\n\026)Tj 10.65 0 Td (\n\t\001\036\004\027\026\016 \017\035\017 )Tj 0.872 -1.2 Td (\n\t\001\036\004\027\026\016 )Tj 0.016 -1.2 Td (\023\035\026\f\021\017\027\022\026 )Tj -0 -1.2 Td (\f\035\017\017\f\021\024\005 )Tj 7.242 3.6 Td (4, 2)Tj 6.137 0 Td (\020\024\n\024\020\036\027\027\026\016)Tj 10.254 0 Td (\r\036\030\036\021\036\027\024\022\035\036\021\024\004\027\026\016 )Tj -1.029 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\r\024\005 \f\021\030\024\n\024\005)Tj 15.184 1.2 Td (\017\027\024\020\007\026, )Tj -3.468 -1.2 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )Tj 0.936 -1.2 Td (\007\017\026\020\027\024\f\021\017\022\036 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210)Tj -46.793 -2.633 Td (\231\r\026\027\027\024\n\026)Tj 10.65 0 Td (\n\t\001\036\004\027\026\016 \017\035\017 )Tj 0.181 -1.2 Td (\023\024\007\f\035\017\017\f\021\026\016)Tj 7.949 1.2 Td (4, 3)Tj 15.806 0 Td (\r\036\030\036\021\036\027\024\022\035\036\021\024\004\027\026\016 \f\024\ )Tj -0.641 -1.2 Td (\f\021\030\031\022\021\031\030\026\n\017 \r\036\030\024\022\026\016 \017\ \035\017 )Tj -0.513 -1.2 Td (\001\r\026\027\027\024\r\f\022\017\n\017 \f\021\030\031\022\021\031\030\026\ \n\017)Tj 15.894 2.4 Td (\017\027\024\020\007\026, )Tj -3.468 -1.2 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )Tj 0.936 -1.2 Td (\007\017\026\020\027\024\f\021\017\022\036 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210)Tj -46.793 -1.433 Td (\203\036\005\030\024\220\027\007\024\022\030\017\027\027\026\016 )Tj T* (\024\023\031\b\024\035\034)Tj 10.706 1.2 Td (\f\035\017\017\f\021\026\016 \017\035\017 )Tj 0.124 -1.2 Td (\023\024\007\f\035\017\017\f\021\026\016)Tj 7.949 1.2 Td (2, 3)Tj 3.993 0 Td (\020\024\n\024\020\036\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 )Tj 2.336 -1.2 Td (\022\024\027\021\031\030\026\n\017)Tj 8.468 1.2 Td (\024\030\020\026\027\024\017\007\027\t\005 \021\017\023 \f\021\030\024\036\ \027\017\016 )Tj 14.405 0 Td (\021\030\036\002\031\036\021\f\016 \007\035\016 )Tj -0.885 -1.2 Td (\235\036\027\024\021\017\023\017\030\024\r\026\027\017\016 )Tj -0.836 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016 \020\030\036\005\007\026 )Tj -46.26 -1.433 Td (\200\024\f\023\026\035\017\021\036\035\034\027\t\005 )Tj 0 -1.2 TD (\235\017\002\030\024\027\t\005 \023\024\035\017\023 )Tj 11.522 1.2 Td (\n\t\001\036\004\027\026\016 )Tj 0.016 -1.2 Td (\023\035\026\f\021\017\027\022\026 )Tj -0 -1.2 Td (\f\035\017\017\f\021\024\005 )Tj 7.701 2.4 Td (3)Tj 5.01 0 Td (\020\017\023\024\220\b\024\020\036\027\027\026\016 )Tj -1.773 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\036\021\022\017\n\017 \022\024\027\021\031\030\026\n\017)Tj 12.021 1.2 Td (\235\017\002\030\024\002\035\026\f\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\017 )Tj 2.248 -1.2 Td (\r\024\f\023\026\035\036\027\017\016 )Tj -36.745 -2.633 Td (\210\023\031\b\024\035\034 \202\002\030\017\022\024\f\024\r\026 )Tj 0 -1.2 TD (\(\036\030\027\017\f\021\024-\022\035\036\021\024\004\027\026\016\))Tj 11.522 1.2 Td (\n\t\001\036\004\027\026\016 )Tj 0.016 -1.2 Td (\023\035\026\f\021\017\027\022\026 )Tj -0 -1.2 Td (\f\035\017\017\f\021\024\005)Tj 7.701 2.4 Td (3)Tj 5.01 0 Td (\020\017\023\024\220\b\024\020\036\027\027\026\016 )Tj -1.773 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\036\021\022\017\n\017 \022\024\027\021\031\030\026\n\017)Tj 12.609 1.2 Td (\036\030\027\017\f\021\024\022\035\036\021\024\004\027\t\005 )Tj 14.334 0 Td (\017\027\024\020\007\026)Tj -49.418 -3.833 Td (\202\002\036\030\030\026\027\021\027\026\016 )Tj T* (\023\024\007\032\036\035\031\007\024\004\027\026\016 )Tj T* (\032\036\035\036\026)Tj 22.302 2.4 Td (\020\036\021\036\030\024\020\036\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\017\n\017 )Tj 1.327 -1.2 Td (\020\017\023\036\030\220\b\024\020\036\027\027\t\n\017 )Tj -1.639 -1.2 Td (\r\022\035\033\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n )Tj 1.047 -1.2 Td (\023\030\024\021\024\022\024\r\024\005 \f\017\f\021\036\n\t)Tj 12.668 3.6 Td (\026\006\017\027\026\030\027\026\016 \021\022\026\027\034 )Tj -1.489 -1.2 Td (\023\024\007\032\036\035\031\007\024\004\027\024\005 \032\036\035\036\t\ )Tj 13.998 1.2 Td (\027\036 \021\030\036\002\031\036\021\f\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.9152 56.0378 Tm (174)Tj ET endstream endobj 101 0 obj <> endobj 98 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.021 Tw 10 0 0 10 42.5197 724.8299 Tm (\025\026\022 \023\030\026\r\017\035\024, \020\017\f\021\024\035\024\020\017\ \004\036\f\022\026\016 \r\036\030\017\235\017\022\026\006\017\016 \035\017\ \023\024\n \027\036 )Tj 0.184 Tw 0 -1.218 TD [(\r\t\t\r\026\036\021 )0.5(\021\030\031\007\027\024\f\021\036\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.319 0 Td [(\027\036 )0.5(\021\030\036\002\031\036\021 )0.6(\007\024\023\024\035\027\017\021\036\035\034\027\t\b )]TJ -0.045 Tw -10.319 -1.218 Td (\n\036\021\024\007\024\r \235\036\027\024\021\017\023\017\030\024\r\026\027\ \017\016, \021\026\022\017\b \022\026\022 \017\n\n\031\027\024\020\017\f\ \021\024\b\017)Tj 0 Tw (-)Tj -0.036 Tw T* (\n\017\004\036\f\022\017\005 \017\035\017 \n\024\035\036\022\031\035\016\ \030\027\t\005 \n\036\021\024\007\t. \221\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\017 )Tj /T1_2 1 Tf 0 Tw T* (\f\r\005\002\214\t\002\217\004\006\220\002\214\013 )Tj /T1_1 1 Tf 0.039 Tw 7.894 0 Td (\r\024\027\017\022\026\036\021 \027\036\024\002\b\024\007\017\n\024\f\021\ \034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031)Tj 0 Tw (-)Tj 0.123 Tw -7.894 -1.218 Td (\027\024\020\017\f\021\024\b\017\n\017\004\036\f\022\024\020\024 \(\230\206\ \216\) \235\036\027\024\021\017\023\017\030\024\r\026\027\017\017 \024\023\ \031\b\024)Tj 0 Tw (-)Tj 0.192 Tw 0 -1.218 TD [(\035\017. )0.5(\214\036\005\024\n\017\024\f\026\030\022\024\n\t )0.5(\004\030\036\r\t\004\026\005\027\024 )0.6(\030\036\007\022\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 19.554 0 Td (2000\226)Tj 0.11 Tw -19.554 -1.218 Td (2019)Tj /Span<>> BDC ( )Tj EMC (\020\020. \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \024\023\017\f\t\r\026\036\021\f\ \016 \035\017\001\034 76)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036\r )Tj 0.086 Tw 0 -1.218 TD (\(\007\024 2000 \020\024\007\026 \n\027\024\020\017\036 \206\230\222\210\ \002\t\035\017 \027\036\023\030\026\r\017\035\034\027\024 \022\035\026\f\ )Tj 0 Tw (-)Tj 0.179 Tw T* (\f\017\235\017\006\017\030\024\r\026\027\t \022\026\022 \035\036\005\024\ \n\017\024\f\026\030\022\024\n\t\). \215\030\016\n\026\016 \022\017\001)Tj 0 Tw (-)Tj 0.416 Tw T* (\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 \036\007\017\027\f\021\r\036\027\027\t\005 \024\030\020\026\027 \032\ \036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024 )Tj 0.013 Tw T* (\021\030\026\022\021\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \035\036\005\024\n\017\024\f\026\030\022\024\n\ \026 \r\f\021\030\036\004\026\036\021\f\016 \004\026\013\036, )Tj 0.017 Tw 0 -1.218 TD (\004\036\n \206\230\222\210. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \n\024\030\235\024\035\ \024\020\017\004\036\f\022\031\033 \007\017\235)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\235\036\030\036\027\006\017\026\035\034\027\031\033 \007\017\026\020\027\ \024\f\021\017\022\031 \035\036\005\024\n\017\024\f\026\030\022\024\n \023\ \030\024\r\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\007\016\021 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210, \027\024 \027\036 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\023\024\n\024\005.)Tj /T1_2 1 Tf 0.32 Tw 0 -2.436 TD (\027\004\217\003\006\002\t\b\003\r\217\003\t\b\004\f\001\b\013\r \217\003\ \006\002\214\004\f\001\b\013\r \002\212\210\216\002\f\t)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (\227 )Tj 0.651 Tw 0 -1.218 TD [(\027\026\017\002\024\035\036\036 )0.6(\004\026\f\021\024 )0.5(\r\f\021\030\036\004\026\033\013\017\036\f\016 )0.6(\017\027\021\030\026\n\031\030\026\035\034\027\t\036 )]TJ 0.246 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\016. \210\027\017, \023\ \030\036\017\n\031\013\036\f\021\r\036\027\027\024, \030\026\r\017\r\026\ )Tj 0 Tw (-)Tj 0.253 Tw T* (\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\017 \022\035\026\f\f\017\ \235\017\006\017\030\031)Tj 0 Tw (-)Tj 0.181 Tw T* [(\033\021\f\016 )0.5(\022\026\022 \r\036\030\036\021\036\027\024\022\035\036\021\024\004\027\t\ \005 )0.5(\021\017\023 )0.5(\(\007\024 70%\) [31,32]. )]TJ 0.081 Tw T* (\233\021\017 \024\023\031\b\024\035\017 \r\024\027\017\022\026\033\021 \ \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\f\021\017\006\017\026\035\034\027\t\b \022\035\036\021\ \024\022 )Tj 0.24 Tw T* (\025\026\b\026\035\016, \022\024\021\024\030\t\036 \016\r\035\016\033\021\ \f\016 \220\035\036\022\021\030\017\004\036\f\022\017\n\017 \r\024\007\017\ \021\036)Tj 0 Tw (-)Tj 0.031 Tw T* (\035\016\n\017 \030\017\021\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\021\024\030\026\n\017 \220\027\021\036\030\026\035\034\ \027\024\005 \027\036\005\030\024\021\030\026\027\f)Tj 0 Tw (-)Tj -0.037 Tw T* (\n\017\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\036 \240\025\221\ [33]. \210\002\030\026\024\r\026\027\017\036 )Tj 0.359 Tw T* (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 \(4 \220\b\ \024\f\035\024\005\) \017\035\017 )Tj 0.336 Tw 23.244 30.445 Td (\030\036\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.382 Tw T* (\035\024\004\022\017 \(2 \220\b\024\f\035\024\005\). \210\f\027\024\r\027\ \t\036 \233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\017\ )Tj 0 Tw T* (\206\230\222\210)Tj /Span<>> BDC ( )Tj EMC ([34]:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\004\036\021\022\017\036 \022\024\027\021\031\030\t;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\024\007\027\024\030\024\007\027\026\016 \f\021\030\031\022\021\031\030\026\ ;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\020\017\023\024\220\b\024\020\036\027\027\024\f\021\034 \017\035\017 \023\ \024\027\017\032\036\027\027\026\016 \220\b\024\020\036\027\027\024\f\021\ \034;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\r\024\n\024\032\027\t \220\b\024\020\036\027\027\t\036 \r\022\035\033\004\ \036\027\017\016.)Tj -0.023 Tw -1 -1.218 Td (\025\030\024\n\036 \021\024\020\024, \027\036\022\024\021\024\030\t\036 \ \233\211\222-\023\030\017\027\026\022\017 \n\024\020\031\021 \031\022\026\ \t\r\026\021\034 )Tj 0.248 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\005 \030\017\f\022 \035\024\022\026\004\036\f\021\r\036\ \027\027\024\020\024 \023\036\030\036\030\024\032\007\036\027\017\016. )Tj 0 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n \023\030\017\027\026\022\026\n \024\021\027\024\f\016\ \021\f\016 [35]:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\027\036\030\024\r\027\t\036 \020\030\026\027\017\006\t;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\027\036\024\007\027\024\030\024\007\027\026\016 \220\b\024\020\036\027\027\ \024\f\021\034;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\026\027\220\b\024\020\036\027\027\t\036 \023\024\035\024\f\021\017;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\031\r\036\035\017\004\036\027\017\036 \030\036\020\017\024\027\026\035\034\ \027\t\b \035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\024\r.\ )Tj 0.135 Tw -1 -1.218 Td (\212\035\016 \023\024\f\021\026\027\024\r\022\017 \024\022\024\027\004\026\ \021\036\035\034\027\024\020\024 \007\017\026\020\027\024\026 \021\030\036\ \002\031\036\021\f\016 )Tj 0.152 Tw T* (\r\t\023\024\035\027\036\027\017\036 \233\211\222-\221\230\215 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036\n \023\024\f\035\036\007\031\033\013\ \036\020\024 )Tj 0.321 Tw T* (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\230\206\216 \023\024\007)Tj 0 Tw (-)Tj 0.231 Tw T* (\021\r\036\030\032\007\036\027\017\036\n [36]. \221\024\004\027\024\f\021\ \034 \233\211\222-\221\230\215 \r\026\030\034\017\030\031\036\021 \024\021\ )Tj 0.04 Tw T* (50% \007\024)Tj /Span<>> BDC ( )Tj EMC (93% \017)Tj /Span<>> BDC ( )Tj EMC [(\026\r\017\f\017\021 \024\021 \021\026\022\017\b )0.5(\235\026\022\021\024\030\024\r \022\026\022 \030\026\n\036\030 )]TJ 0.068 Tw T* (\024\002\030\026\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\026 \017\020\035\t [37]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 )Tj 0.292 Tw T* (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016 \031\022\026\t\r\026\033\021 \020\017\f\021\ \024)Tj 0 Tw (-)Tj 0.638 Tw T* (\035\024\020\017\004\036\f\022\017\005 \023\024\007\021\017\023 \024\023\ \031\b\024\035\017 \(\r\036\030\036\021\036\027\024\022\035\036\021\024\004\ \027\t\036 )Tj 0.272 Tw T* (\206\230\222\210 \f\024\f\021\026\r\035\016\033\021 \024\022\024\035\024\ 70%, \220\023\017\021\036\035\017\024\017\007\027\024\022\035\036\021\024\ \004)Tj 0 Tw (-)Tj 0.112 Tw T* (\027\t\036 \206\230\222\210 \f\024\f\021\026\r\035\016\033\021 \024\022\024\ \035\024 20% \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\001\026\027\027\t\005 \023\024\007)Tj 0 Tw (-)Tj 0.009 Tw T* (\021\017\023)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\022\024\035\024 10%\), \022\024\035\017\004\036\f\021\r\024 \n\ \017\021\024\024\r, )0.5(\031\030\024\r\036\027\034 \220\022\f)]TJ 0 Tw (-)Tj 0.147 Tw T* (\023\030\036\f\f\017\017 CD117, DOG1, CD34, \023\030\017\004\036\n CD117\ \016\r\035\016\036\021\f\016 )Tj ET q /GS0 gs 453.543294 0 0 220.5324361 42.5196838 176.6469767 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.073 Tw 9 0 0 9 42.5197 165.7701 Tm (\022\t\217\210\b\002\220 10.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\025\030\031\203\031\023\031. \230\025\030\031\024\031\025\031\b\032\ \020\203\022\t. \220\022\203\203\027\032\027\025\006\022\020\f\017\025\013\ \027 \204\200\031\033\032\022\016\025\020\n\022 \022\025\023\032\020\026\ \r\032\020\f\017\025\013\200 \025\031\021\031\031\240\032\020\016\031\021\ \020\025\022\235: \003)Tj /Span<>> BDC ( )Tj EMC (\227 \b\020)Tj 0 Tw (-)Tj 0.013 Tw 0 -1.2 TD (\024\023\032\031\022\025\023\027\024\023\022\025\020\f\017\025\020\t \024\ \023\032\031\026\020\f\017\025\020\t \031\033\r\200\031\f\017 \255\027\f\ \r\030\n\020; \221)Tj /Span<>> BDC ( )Tj EMC (\227 \f\027\235\031\026\022\031\026\020 \255\027\f\r\030\n\020; \211)Tj /Span<>> BDC ( )Tj EMC (\227 \213\021\020\025\025\031\026\020 \255\027\f\r\030\n\020; \216)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027\235\032\031\204\025\030\031)Tj 0 Tw (-)Tj 0.048 Tw T* (\n\032\022\025\025\020\t \031\033\r\200\031\f\017 \255\027\f\r\030\n\020\ ; \220)Tj /Span<>> BDC ( )Tj EMC (\227 \021\031\024\033\020\f\022\023\027\f\017\025\013\235 \203\022\240\032\ \031\016\025\013\235 \033\031\f\022\033 \033\022\212\027\021\031\030\020\ ; \036)Tj /Span<>> BDC ( )Tj EMC (\227 \020\240\027\032\032\020\025\023\025\020\t \033\031\030\255\027\f\r\ \030\031\007\025\020\t \255\027\f\027\016\020 )Tj 0.058 Tw T* (\255\027\f\r\030\n\020; \234)Tj /Span<>> BDC ( )Tj EMC (\227 \016\027\032\025\022\024\023\031\n\f\027\023\031\007\025\020\t \031\ \033\r\200\031\f\017 \033\022\212\027\021\031\030\020; \207)Tj /Span<>> BDC ( )Tj EMC (\227 \030\r\033\f\022\n\020\006\022\031\025\025\020\t \n\022\024\023\020\ \(\204\025\030\031\203\031\023\031 \016\020\022\026\024\023\021\031\021\ \020\025\031 Wahi J.E., )Tj 0 Tw T* (Safdie F.M. [56]\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.093 Tw T* [(F)-16(igure 1)70(0.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endopho)13(to. Endosonog)14(raph)12(y)32(. Dif)-39.9(ferential echo signs of)]TJ /Span<>> BDC ( )Tj EMC [(intramural neoplas)33(ms: \003)]TJ /Span<>> BDC ( )Tj EMC [(\227 g)12(astrointestinal stromal tumor )]TJ -0.032 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the stomach; \221)Tj /Span<>> BDC ( )Tj EMC [(\227 g)12(astr)-37(ic leiom)11.1(yoma; \211)]TJ /Span<>> BDC ( )Tj EMC [(\227 g)11.9(astr)-36.9(ic schw)13(annoma; \216)]TJ /Span<>> BDC ( )Tj EMC [(\227 neuroendocr)-37(ine tumor of)]TJ /Span<>> BDC ( )Tj EMC (the stomach; \220)Tj /Span<>> BDC ( )Tj EMC [(\227 inf)-22(lammator)-43(y )]TJ 0.005 Tw T* [(f)-43(ibrous )0.6(polyp )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.387 0 Td [(the )0.5(esophagus; )0.5(\036)]TJ /Span<>> BDC ( )Tj EMC 6.864 0 Td [(\227 )0.5(aber)-16(rant )0.5(pancreas )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 9.564 0 Td [(the )0.5(stomach; )0.5(\234)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(g)14(ranular )0.5(cell )0.5(tumor )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 16.353 0 Td [(the )0.5(esophagus; \207)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(duplica)]TJ 0 Tw (-)Tj -39.169 -1.2 Td [(tion cyst \(endopho)13.1(to bor)-15.9(row)12(ed from W)30.1(ahi J.E., Safdie F)94.2(.M. [56]\))]TJ ET 1 0.68 0 0.12 k /GS0 gs 42.52 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 49.2345 292.3557 Tm (A)Tj ET 1 0.68 0 0.12 k 42.52 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 49.1795 182.5039 Tm (\031)Tj ET 1 0.68 0 0.12 k 155.055 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 161.7755 292.3557 Tm (\224)Tj ET 1 0.68 0 0.12 k 155.055 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 162.2429 182.5039 Tm (\036)Tj ET 1 0.68 0 0.12 k 273.26 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 279.9747 292.3557 Tm (\026)Tj ET 1 0.68 0 0.12 k 273.26 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 278.7592 182.5039 Tm (\207)Tj ET 1 0.68 0 0.12 k 386.15 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 393.4639 292.3557 Tm (\027)Tj ET 1 0.68 0 0.12 k 386.15 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 393.3099 182.5039 Tm (\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 505.5395 56.0378 Tm (173)Tj ET endstream endobj 99 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  {!1A"Qaq2S#3BRbr $%&'()*456789:CDEFGHIJTUVWXYZcdefghijstuvwxyzy!1AQaq"2B#$CR3br %&'()*456789:DEFGHIJSTUVWXYZcdefghijstuvwxyz?ǝ}sqX5sasc.!#~%z\9dN/f(cU:׫s^Hơ m.CY38>ẳgY-˄ֺub9jTwf3j=3: ,Su_ϣ Igϣ Anhxƫvs?8 *"pY2, ՟.2ωt@0ËGu͹jU$uB!ru_ϣ HџGgī.+L?LuʟuwTSMd:?F]e>gѿp%ä ;=;_5B ՟.3#F]g[0R 0h_T1~SӻʫrY}_ˣ HїF{ւYx>GvbwWHB~to?pW28Q/u%[ݘ?GuwTїG .3.shS_T1~Sӻʪ: ˣ HїGMhh`2+TyTxGfDKze0$}gˣ aK ON*;=;! ?F]a>ze0%JON*;=;ABїG .3.b5h%Ghoj1~}SӻʟuwU8;! nto?pW28khZ:)ެ_Tݘ>P@ }uYto??^t?Xh{ݻ=;_"%S ՟.1#?F]cV@8#9\8V+ʩIe ՟.2ωzl?>%ZƏ=;UxvT}b*2fj92$cƘqHct ՟.1.|^}a<&+u-$A+i!H楉DڏiMKUe=Y_p]U1>ຫcѿ0%gݘzUB~ຫcѿ0%A U_1~}S;ʪ'H_?F]aj/V~?ľ/y(gvbw׊ꞙUY)! ?F]gG/V~?Ļ@EսًꞙTwf/ϪzwyUHB/V~7ďNt|K OL|_T򪐈\?pW2, ՟.0ωw"OL|_TʪB !pugˣ aHїGgĻ_T1~}S;ʪB~:e0$zeѿ0%D+{=;_T򪐚/V~?ď^t?w"ON*;=;! ?F]cG/U?ĻS ON*;=;! ?F]cG/U?Ļ_g5ON*$ ՟0ϵA^.1.P{=;_B>:e;A~&=ݍ" zUM"їGgďNt|K4D{z*LU؆2nq 0| >$PII|}V?6]eϢ8xÝ7 J&MUa5܀crM\s= C= v&hBk F=cGU~z7ľjON*;=3f&%R<;2jU9Z#nU Wǣ aNNmFjDe}礗bl4j 5(V/ϪzgyQX>]pZ#q<0qf Sˈ5g =sД3 ȋquֿpQ2>zeѿ0x}aǑBv6t#ж_Q_ѻ $mMx;=3_Tv"蔗џF >3-bu2iiS_T~}S;ʠzҋ,SuGˣ aH8'|lZUՌꞙTwV/ϪzgyT=ޤv"Pảgѿp$Ả?(}?dp%' Juc2#cs8d=Y4/j 6Ÿ?mg˄t>/1,f{Z?C];ccqZJNV/ϪzgyUܑ=[Yp)JgFpz atsnLKt>a4n-k<#nX>@cjzgyQ=画$BG:D>_?'WSa6LWWs,+F،v:.߅GxR_T򣺱5OL*$3tP->3$zEĸExk[`KKg$Ik X>GucU!4.>o?GU~z7گouw׋ꞙUR~cѿ0p}U1jĭlsG0v*r^|c|tAoLꞨ%IZ I@347@ES/u>h"'aAݠH@ Z3TPI+fq19䣺dY"".B o-q,DˈFɂ% -j(~(tNegH"Ԝ6*!*wa\*"i3D'(SBHЪex lNI BKL1waaAMpM%-R$K ,p睢-~(x% " m(&Naddۜ'KTʌ)A;nZ <0M$AA@q&@}HABEIBcG.ѽCn! 4IU%+tbzsBB)nB!QI$!B0Nf!L&7BR!)֋7b5.V͋"GxDHBq$Yma;jrVX) ޾12]1k͚+W`~&&vd[˜lh& EĨGdô0'1:oM M<5Ln:DžI]6yB849l֋`!I!ru ,CYvGGbG$c^6SklS2=z1?;KqEJxX m.4.n~6l%@nn6'f{- 0" oek)t=Ru) ?jͦLH7zPh=|~_iؘ&=&z?K0l!YJQtJkwZA]\]m6FM  %"FO)$# Ns[ԁfqeT(*mkk 16l;CK|WwEdݓDLNDZ/ݪMr 5v"@BP.;NE$ H,UxcIlPR B]=] bm;&LI&(\ L5wR&!@IDj(J]\BԒy(!MRI6LQ"`(.$I B{{T8(B/.$hBZ*Y>P.TB%Q\;- ewt$\P6L0DH>&(5 \'ڥt@ױ| bu/v^a CCm0|-!a7kBRv vɾ׶溎Li.6O( F8Kdw tn5FΓ GH2bFaըSD G-RMz| 6s#"`N@*0zKW}-gv[7.$qRޱa۴bs#-*\G4(Š .;&АHq։JW;kD{Fcytr&ѐF/[vxia8;Cf "$[R$hhQ "Q-HuapcqX; aC ƣG@ZC{XQk5$dJe}PxXb;UR gtQ0c s0 mȄ!ZK!B!BCtF!sbǒb(EBUMЁTҠNSI0 S 9J[YdA0ޕ04! 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(bHIEX8'zT:3f>!o<SUdRmGZA:&@~ &ZrkG s ;,k^qtA't-1C#E"Ri.Sc*7+{\ Mn,<+bb>XƚE=}vk ?x}'k?O A}FWU$d& xߍlDbyb}=M8)!D$u u*kC4h:,ŔoKCq ADPBНgb3)Y 9BLε]^nn!NqTS`Isu^n\嚩YGB1!wmZ#n=B=ӿBpK`S.&"2$G|% XhJ=D:w#؊7hRnA>%VxP/$HQBx![Dn՝^Ή^}ح (_1D 9Q ^aLlu+ WBaݪj8*3t,Fdm`'$꾓:&> s1CJي)ql1^Q~cW mx)J+8XaLxe`/貹#z?Y7`I P8;TGPtz;z1%$]?zkK;ʅjm ˇ#0YS_Oza<th{1 lm+Ac,iNҞi {*+2n%fvY]藧F._g}aaުJE{VJr3tLju4'I'%$Bd,[L[ NWohԔ'0֊I ^[>?V}/ |cąM 5+%up>Rh4 >e:ըs#@_gۣF3EZ}t޷~wa4kLSy_;ߥu&;E frXU3qUa)8H벛k:MׁqApJ'" BqquܾY^ݧ  tL-o34 uZzēƁ< Uԕ/<ݡo3+"CnOR8},`QU5L0S_ mЅy× f:z+?o 50htAKmsismouMZ$0&NI8ýnΕÆǖ RZ6EhHparܹzK5..%#EԂѸ,!~]?fWIjJo&ɅP~=4^{Ert1лSje7 m|6-CZ{;lz. %{qq6o:WMvHMhv.kN}6Դ!vq>MbpNe*-k溓y EqPL-սUӺ]Ǥ^bᆖ⊉"f(B! !B!B!B!B!B!B!B!B!B!B!B!B!B!B!M) B\[/-֌),U φ6voe}_Jf w:^AMi,w,8ڼkX YSB\]Vpy r]I$!BhB!B!B!B!BIB!BBHB!4$!BHB!9BHB&IB&R! IRd͔Tg!\]c WOh~-4_Buz*9KlJkcTоOK' f]hY{W{1a%.V +`Xp9H4Sw2Bynոİ6r!„/Wb0($8 踇4 @u(ד u. &GZ굁8H)V_ e7drVr6\ wfjQ:f-`\K U6S\89 u8hgIi!yT/9(ii6R8_C<#V3aͱ^)aJ@}bAA#u<<\x ln+\ :GI`Ƕ3m}Y-ЂJ>AXvHp  g5= 86dXY|tfgp&$ h{@p R 뮎Z k+l?l.ӗI 4{A]Z8jfRtbH=bl8|`HM*]O̫ YauBˀZa}uY8^Z\a軇 7VMGL0ִ2lS\eN(BGH'}>}b@*C  {$[k"Y[su& lRW9x:DGA6)!su]TU8r9i Pqv!sC$o hhoBm \H^Gҏf+JOszvA.WL`~& ?wzH@ endstream endobj 284 0 obj <>stream endstream endobj 93 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.018 Tw 10 0 0 10 70.8661 724.8299 Tm (\f\021\036\027\022\017 \032\036\035\031\007\024\004\027\024-\022\017\001\ \036\004\027\024\020\024 \021\030\026\022\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (7\2269\) [26]. )Tj 0.299 Tw 0 -1.218 TD (\222)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \027\026\035\017\004\017\016 \023\026\021\024\020\ \027\024\n\024\027\017\004\027\t\b \023\030\017\027\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.094 Tw T* [(\220\021\017\b )0.5(\031\027\017\022\026\035\034\027\t\b )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022 )0.6(\035\017\023\024\n\t, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.138 0 Td (\002\024\035\034\001\017\027)Tj 0 Tw (-)Tj 0.162 Tw -18.138 -1.218 Td (\f\021\r\036 \f\035\031\004\026\036\r \023\024\021\030\036\002\027\024\f\ \021\034 \020\017\f\021\024\035\024\020\017\004\036\f\022\024\005 \r\036\ \030\017\235\017)Tj 0 Tw (-)Tj T* (\022\026\006\017\017 \024\021\f\031\021\f\021\r\031\036\021 [28].)Tj 0.922 Tw T* (\200\t\001\036\031\022\026\026\027\027\t\036 \220\027\007\024\f\024\027\ \024\020\030\026\235\017\004\036\f\022\017\036 \023\030\017\027\026\022\ \017 )Tj 0.007 Tw 0 -1.218 TD (100% \f\023\036\006\017\235\017\004\027\t \007\035\016 \035\017\023\024\n\ \t \(\036\007\017\027\f\021\r\036\027\027\024\036 \020\017\023\036\030)Tj /Span<>> BDC (-)Tj EMC 0.301 Tw 0 -1.218 TD (\220\b\024\020\036\027\027\024\036 \017\027\021\030\026\n\031\030\026\035\ \034\027\024\036 \024\002\030\026\024\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\036\n )Tj 0.196 Tw T* (\220\b\024\f\035\024\036\), \023\024\f\022\024\035\034\022\031 \035\017\023\ \024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\240\025\221 \023\030\026\022\021\017\004\036\f\022\017 \027\036 )Tj 0.248 Tw T* (\017\n\036\036\021 \030\017\f\022\026 \035\024\022\026\004\036\f\021\r\036\ \027\027\024\020\024 \023\036\030\036\030\024\032\007\036\027\017\016, \021\ \024\027)Tj 0 Tw (-)Tj 0.064 Tw T* [(\022\024\017\020\024\035\034\027\026\016 \023\031\027\022\006\017\016 )0.5(\023\024\007 \022\024\027\021\030\024\035\036\n \220\027\007\024\f\024\027\ \024\020\030\026\235\017\017 )]TJ 0 Tw T* (\(\233\211\222-\221\230\215\) \027\036 \021\030\036\002\031\036\021\f\016\ .)Tj 0.073 Tw 0 -1.218 TD (\222\024\020\035\026\f\027\024 \030\036\022\024\n\036\027\007\026\006\017\ \016\n, \233\211\222-\221\230\215 \023\024\022\026\026\027\026 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\027)Tj 0 Tw 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[(\024\r\026\027\017\036 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b )0.5(\n\036\021\024\007\024\r )0.6(\r\017\031\026\035\017\026\006\017\017, )]TJ 0.133 Tw T* (\220\027\007\024\f\024\027\024\020\030\026\235\017\017 \017, \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017, \n\024\030\235\024\035\024\ \020\017)Tj 0 Tw (-)Tj 0.288 Tw T* (\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016. \230\ \027\021\030\026\n\031\030\026\035\034\027\t\036 \027\024\r\024\024\002\030\ \026)Tj 0 Tw (-)Tj 0.06 Tw T* [(\024\r\026\027\017\016 \024\030\020\026\027\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 )0.5(\021\030\026\022\021\026 \n\024\020\031\021 )]TJ 0.135 Tw T* (\002\t\021\034 \027\036 \021\024\035\034\022\024 \007\024\002\030\024\022\ \026\004\036\f\021\r\036\027\027\t\n\017, \027\024 \021\026\022\032\036 \ \035\024)Tj 0 Tw (-)Tj 0.008 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\n\017 \017\035\017 \017\n\036\021\ \034 \035\024\022\026\004\036\f\021\r\036\027\027\t\005 \023\024\021\036\ \027\006\017)Tj 0 Tw (-)Tj 0.146 Tw T* [(\026\035. \233\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \031\035\ \034\021\030\026\f\024\027\024\020\030\026\235\017\016 )0.5(\(\233\211\222\) \f\031\013\036)]TJ 0 Tw (-)Tj 0.007 Tw T* [(\f\021\r\036\027\027\024 )0.5(\030\026\f\001\017\030\016\036\021 )0.5(\r\024\n\024\032\027\024\f\021\017 )0.5(\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )]TJ 0.415 Tw T* [(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\017\027\021\030\026\n\031\030\026\035\034\027\t\b )0.6(\024\002\030\026\024\r\026\027\017\005 )0.5(\f\021\036\027\022\017 )]TJ 0 Tw T* (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ \021\030\026\022\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (10\).)Tj 0.028 Tw T* (\204\027\024\020\017\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\017\b \n\024\032\027\024 \017\007\036\027\021\017\235\017\006\017\030\ \024\r\026\021\034 )0.5(\f\030\026\031 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\017\b )Tj 0.08 Tw T* (\233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\026\n, \024\ \f\024\002\036\027\027\024 \035\017\023\024\n\t, \027\024 \007\035\016 \007\ \030\031)Tj 0 Tw (-)Tj 0.387 Tw T* [(\020\017\b \021\030\036\002\031\036\021\f\016 \020\017\f\021\024\035\024\ \020\017\004\036\f\022\026\016 )0.5(\r\036\030\017\235\017\022\026\006\017\016. \212\035\016 )]TJ -0.081 Tw T* (\022\026\032\007\024\020\024 \021\017\023\026 \024\002\030\026\024\r\026\ \027\017\016 \b\026\030\026\022\021\036\030\027\t \f\r\024\017 \f\023\036\ \006\017\235\017)Tj 0 Tw (-)Tj 0.012 Tw T* (\004\036\f\022\017\036 \233\211\222-\023\030\017\027\026\022\017, \004\021\ \024 \023\024\r\024\035\016\036\021 \024\021\035\017\004\026\021\034 \017\ \b \007\030\031\020 )Tj 0.109 Tw T* (\024\021 \007\030\031\020\026. \025\030\024\n\036 \021\024\020\024, \007\ \035\016 \022\026\032\007\024\020\024 \024\030\020\026\027\026 \b\026\030\ \026\022\021\036\030)Tj 0 Tw (-)Tj 0.12 Tw T* (\027\024 \023\030\036\024\002\035\026\007\026\027\017\036 \024\023\030\036\ \007\036\035\201\027\027\024\020\024 \r\017\007\026 \024\023\031\b\024\035\ \017. \221\026\022, )Tj 0.146 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\017\013\036\r\024\007\036 75% \r\f\036\b \027\024\r\024\024\002\030\ \026\024\r\026\027\017\005 \f\024\f\021\026\r\035\016\033\021 )Tj 0.008 Tw T* (\035\036\005\024\n\017\024\n\t, \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 60% \017\027\021\030\026\n\031\030\026\035\034\ \027\t\b \023\024\030\026\032\036)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\ \t\036 \f\021\030\024\n\026\035\034\027\t\036 \024\023\031\b\024\035\017\ )Tj 0.075 Tw T* (\(\206\230\222\210\), \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\036)Tj /Span<>> BDC ( )Tj EMC (\227 \035\036\005\024\n\017\024\n\t, )Tj 0.018 Tw T* (\206\230\222\210, \027\036\005\030\024\220\027\007\024\022\030\017\027\027\ \t\036 \024\023\031\b\024\035\017 \(\203\233\210\) \(20% \r \022\026\032\ )Tj 0 Tw (-)Tj -0.01 Tw T* (\007\024\n \f\035\031\004\026\036\) [30]. \222\r\024\036\r\030\036\n\036\ \027\027\026\016 \007\017\235\235\036\030\036\027\006\017\026\035\034\027\ \026\016 )Tj 0.077 Tw T* [(\007\017\026\020\027\024\f\021\017\022\026 \023\024\r\024\035\016\036\021\ )0.5(\024\023\030\036\007\036\035\017\021\034 \007\026\035\034\027\036\005\001\ \031\033 \021\026\022)]TJ 0 Tw (-)Tj T* (\021\017\022\031 \035\036\004\036\027\017\016 \023\026\006\017\036\027\021\ \026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj ET q 303.307 564.686 221.102 161.954 re W n q /GS0 gs 221.1023475 0 0 162.0457039 303.307086 564.5941099 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.4 Tw 9 0 0 9 303.3071 553.8859 Tm [(\022\t\217\210\b\002\220 )0.5(7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\230\025\030\031\024\031\025\031\b\032\020\203\022\t )0.5(\026\022\025\022\030\020\023\007\022\n\031\026 )]TJ 0 Tw 0 -1.2 TD (20)Tj /Span<>> BDC ( )Tj EMC (\215\216\006. \035\022\033\031\026\020 \025\022\255\025\027\b\032\r\030\025\ \031\b\031 \031\023\030\027\f\020 \033\022\212\027\021\031\030\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.189 Tw T* [(F)-16(igure 7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. Endosonog)14.1(raph)12(y with a)]TJ /Span<>> BDC ( )Tj EMC (20 MHz mini)Tj 0 Tw (-)Tj T* [(p)46(robe. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC [(the low)12.2(er thoracic esophagus)]TJ ET q 303.307 349.028 221.102 161.954 re W n q /GS0 gs 221.1023475 0 0 162.0457039 303.3070555 348.9361812 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.4 Tw 9 0 0 9 303.3071 338.2279 Tm [(\022\t\217\210\b\002\220 )0.5(8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\230\025\030\031\024\031\025\031\b\032\020\203\022\t )0.5(\026\022\025\022\030\020\023\007\022\n\031\026 )]TJ 0 Tw T* (20)Tj /Span<>> BDC ( )Tj EMC (\215\216\006. \035\022\033\031\026\020 \020\025\023\032\020\f\017\025\031\ \b\031 \031\023\030\027\f\020 \255\027\f\r\030\n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.174 Tw T* [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. Endosonog)14.1(raph)12(y with a)]TJ /Span<>> BDC ( )Tj EMC (20 MHz mini)Tj 0 Tw (-)Tj T* [(p)46(robe. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC (the antrum of)Tj /Span<>> BDC ( )Tj EMC (the stomach)Tj ET q 303.307 133.37 221.102 161.954 re W n q /GS0 gs 221.1023475 0 0 162.0457039 303.3070555 133.2782526 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.4 Tw 9 0 0 9 303.3071 122.57 Tm [(\022\t\217\210\b\002\220 )0.5(9.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\230\025\030\031\024\031\025\031\b\032\020\203\022\t )0.5(\026\022\025\022\030\020\023\007\022\n\031\026 )]TJ 0.156 Tw T* (20)Tj /Span<>> BDC ( )Tj EMC (\215\216\006. \035\022\033\031\026\020 \025\022\024\200\031\030\t\212\027\ \235 \007\020\024\023\022 \030\021\027\025\020\030\006\020\023\022\033\027\ \032\024\023\025\031\235 )Tj 0 Tw T* (\n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.178 Tw T* [(F)-16(igure 9)31.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13.1(to. Endosonog)14(raph)12.1(y with a)]TJ /Span<>> BDC ( )Tj EMC (20 MHz mini)Tj 0 Tw (-)Tj T* [(p)46(robe. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC (the descending duodenum)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8276 56.0378 Tm (172)Tj ET endstream endobj 95 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,R""  !1AQ"a2Bq# $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyzi!1A"Q2aqBR3 #$%&'()*456789r:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz?|E3ҽڲ.Ζ|\v03XI"w<~dʜX\WE\o})O/ t~ljVp U{op-uSpH}*gvm]KV& RPVHjίu<_n/ WO:V_uQYoyZHRA)wr:W/vun ;y+ Vh(A;c ]D+n)Mq46;q6dM+#ѲIKc־&S OG#n XQI}R͚G9/ ei.FTň؇0asgd[W xq;k(VVNId5Z}vZؾx-M Za%IЗ. ֹSonp\(wzTƥ k@!8. m&x&ꐎ YQq6҂. :$8#ۻ&`$'m \ئHc~!cbsO:*H"vp⸅IᕩiYǔנ s+@O Î޵x?JP TXt !BE:(B()RME袊M:( JHRJE_EcUeLEw>QMKNdQW5:8To }KK4R(4V~R7r})#Or(4Vpu}Iҕ(:cʒ+U]న!e.'A+eBRKx GT9"EyxlvK- )DRBtAVYիß1L]Q> ̀Ľ$&(["EeyvH9PS~Q p0 $AH+ew֒T94z#hhiV+ 8yM|MHR5K$&dPifoyDQ[h$q|bF!*)`kg B5ja)A9(TVu]X8&%kؘTSLL-Ek"H J|*^!jEdEۄ`#r㳁=o"z+M%VԐ;oZ\!QB46ʑk}(FhtWkOyLH|[j$!:OMny'En7CT,,:ďZJdx5(oQRTdu RrRt8\+q#_ى /IyvWwmϿU{ י!AټOm )! $$-(=p\aI^z1ӧ:ݧ?vW֑|׻X)Wx8950B4`^Mz/!qC6{G56Mqk;F㸾/ÁqUGxr_5UJ_{^G{S]'Ok}RyuL BTyJ*")*t!EQE$Ejtz?#FaOnivp&NK!xâIzsZCn Ɗ0 :Iaml3K!`1@kۤUR4H\i{7n]ht,oV8"z +5v*GoU~ ]$b猌.U=v⸎))hU IGRBnL_.{}޸> kTȂH9OF0G#c( TJ1FgٗMu~W#vvۛQcE 5^O/*þ/]x$\5[RqlWqa$'evƹ~+ci}~8v>Ci`q/|w@EkLd6Ğ ozw)[xV a P+I#X4kz%#CJETy"X V u!A"5(iuI 64USi#ʗKN-!j^OVӶudJitA&% q.]l)Ԃ{*%ٳV-5 e e*  Zqm|799> ܓo!ko?+J5*؟^Ҩ? ῥQ__|QEѣp`9O/>zZZ+pGZN\5;l114}e403[xF1`2\ni,xrE  fݸpQL +5v~V8Unn@5d%0i5_pmUmWl_B>H/r7j]#Mp܇F A)T^ǿoq?8Jav]$oVc8o>WLPЀj/:fM^5Vyv;#iw/_UP䓍n:i*\ē._n۵hEXr{Ͻ*$QSdqQyŭ^ԞSxt2M^bvuŪq'W/{PAӧGmz촧>J}ݷۙjIRBԣI"kUgPw4vJB[R 0Τ=DPv=5F(k8XME]tTRwˀ0vrNd:8 W.!vnJM'p/uVj(U%>Th6G0F#(iZyt)EwSvx 4*@ jEq9ѐzES[B8 CR0Oz69Q*)H.4'Mŕh>⨻w6(.q e*K8em[9)B!jQZt qVD -JG\7H (Dvn(sB Qiq \JH'?CXR]%-\LjIct0ީ4AJEQ`nj(W ڮ*bBoPZRN*< *ߥ6HLkXe I̳e\cjK6n@VuyjsEĺT,:_ϥ\O'5&[ډ`H_THsESq7MBxUYQ$}Vb_ZRh#aWrTBR0E:)-w=7kOh'P?yDBttP(Crk4oVKׯ[o@$ՋWr#|u1|sCY)wKZmj JC(<ɁU+b]+HCs^G}wo6o*xէHԝJv2^svnJ[WЕIySy24ESt^P: Hu`>Ke 4xɯi6qAj8yKb" ꀴ|>{&֎ JCAI#jk8}o%E"xC#Q,Up]{7ܿxrt=~ Jn@v 󣵻3v.8;|'n:='Y $5qMk8O K([;1aԖ} CŅKD"O bk[tH@޾sᬄVsWq) tTUHFqD6˨sܯxd_+OWh *>DW\B{nB{aTJ-'IY',TADž=1S 8QGCܐc.kI @$uă u,CZ|Lb"֊kZh.#zz\nl^N(@ N$ҮXRWm[,l7MX  $,Hb(j9fz-c洐9 1[]o𓙇J#4QM+!nj9̑cHpLGI>+0ș $cd % FC }Y|g mbp!W$gh|w nt".8ڮ -9Iy+}WM=WqJ{! , {0$|!wnm%qkJ. /Jn$_ 5J}(QHb ](Z]gXb2Vҹh%Egyn\$zmXMn@r Ҳ]U¿z*i~7-bIܝ sNn&y@"I N-HEiBN0jjZ 0NMh"zYU\j9nvmVL?ХMR6@v#>J#p=T="i !XqA#C8roU˓ r0F7)I"(E:|@ I:֒`)gDjw@ jFG:(dEh! :O~My *(%ZԠ5_I;Ңwzo6_OĨDBH-ObSmJY" |jzHi 3EjN-z?L C3Y^W,_KwkB݅h@%M=7&pZČRNХH$zM$rd 9]Iթ.Mm5Sa:u$Dh*E 45dȦt3Q~cPwtyD} r-*]\R-^վ%i%@sH 9c\'RI}YER CNj΢(JF(6w% ҭ^ *;7_eaI \ Bd:dljv;iЋjIp}uLCʗ^I׍U7V $'ٚnХ4',~ZKJRiQ t+p 5tT#H.w\EX D[r FQLwHQYm$>#^4*4!zfرïLwMM rJtR>;W[ %BAD3T+ҫh-+W*+_WǶ(4RW /|_mjeR T{7CpZZ^[n7C$z\᏷vo,\?ZNE5[?:j Ύ3W|z7xnuG?DЋ:.f>JB+TRÇ2ix-һ`"^~)6c0=˅z:9%ˋs[q.{c/ws'lb̗"Y$3 \y^B = ZepT'O) ƾ3 P ;:lC*^-jba6Uwb&R;+[vpxkh:qARUf\&N,,$s=8r9={wfhsaig=y{ƽ١\'DPZE?S,O=1gb;ⷲ7J !e)Co!&Np;ˡX ^ڞmokbOpZC%ckR;7m]Mz[,>WodX_pbYU뼵)F@%@V"dhptdQsK` "d &ˍc;Yjy83I?o onhx΃367GѭuiYL@cuvؼ.8~suGv,2v8;]M0ٷs VRhƹOv}ڷ\_ڷf;\@QtbOJF}[n+Е Za(@8p~1Y"!=ָ{@I a9 6t!T먹z br6$jx7{v3>#5x RBTP(䢤6EV]EEDZ5ĥz1e*OGT$%`iޠ]IH(`q@N| *EN9'[1=vf嵤,ԃ܏:ũڂL)4 H b(]I.SmJmMq"_ԑuӪځ;-4*NMR#ޅ ,[|VnG l{d7`uI(NcOe7Bk͹w|pw@صiDNހl[af\Ν%I9օ))pyBj$&ILi:5c[y|MSw;5\ o4TIQ)Zu BszH HN7HT@SY$`ҴiRi'HHۡIzVc)sNCE!Quy4=(R&,7E](@%R1o^O{?`KZBwn8*L"{7Cg~zra-o'#]WEzSj\I5W'EvTQEJ]qdd $޼ Hy+FvCj5%;Bl. {Rv!^ m{ܯޜGGa &-ڲP28,P˥ eݎF.y<#] `7i[9$j ݷdq]n\W zX6!N[w P#?=lv_h\ktii~j\OSIY+t/f_Zs} p{=iAEjot]G2ͻwJM )S&I`Fkѳ~v].ڂZ!I$hBEMjtP2vGakah.`ݷQID5q> nҫ$Mu9w9a$Vcd+"{94-!ع- UkgWAEd| +v>ܼ.qT fi;RԠ߶TT`vj[sQRVĝgR %fNNBO@n 4䞊Kw!9lMipH^ @ 򩋍ޠ դY>UѲ( DR![N=(I$2my%T*vf)O֮+Ttp{JM{ ! 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\024\f\027\024\r\027\t\b \023\016\021\ \017 )Tj 0 Tw T* (\f\035\024\036\r \f\021\036\027\022\017 \032\036\035\031\007\024\004\027\ \024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026:)Tj 0.029 Tw T* (\251)Tj /Span<>> BDC [( )-238( )]TJ EMC 1 0 Td (\023\036\030\r\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\220\b\024\020\036\027\027\t\005, \024\021\030\026\ \032\026\036\021 \031\035\034\021\030\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\r\031\022\024\r\024\005 \f\017\020\027\026\035 \024\021 \f\035\017\017\ \f\021\024\005 \024\002\024\035\024\004\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017)Tj 0 Tw (-)Tj 0.326 Tw T* [(\030\031\036\021\f\016 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 4.71 0 Td [(\f\004\201\021 )0.5(\026\022\031\f\021\017\004\036\f\022\024\020\024 )0.5(\017\n\023\036\007\026\027\f\026 )0.6(\n\036\032\007\031 )]TJ 0 Tw -4.71 -1.218 Td (\023\030\024\f\r\036\021\024\n \024\030\020\026\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \f\021\036\027\022\024\005;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\r\021\024\030\024\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\024\220\b\024\020\036\027\027\t\005, \f\024\007\026\201\ \021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj (-)Tj 0.068 Tw T* [(\b\024\032\007\036\027\017\017 \031\035\034\021\030\026\r\031\022\026 )0.5(\004\036\030\036 \f\024\002\f\021\r\036\027\027\031\033 \n\t\001\036\004\ )]TJ 0 Tw (-)Tj T* (\027\031\033 \023\035\026\f\021\017\027\022\031 \f\035\017\017\f\021\024\ \005;)Tj 0.46 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )193( )]TJ EMC 1 0 Td (\021\030\036\021\017\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\220\b\024\020\036\027\027\t\005, \f\024\024\021\ \r\036\021\f\021\r\031\036\021 )Tj 0 Tw T* (\023\024\007\f\035\017\017\f\021\024\n\031 \f\035\024\033;)Tj 0.252 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-15( )]TJ EMC 1 0 Td (\004\036\021\r\201\030\021\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC [(\227 \020\017\023\024\220\b\024\020\036\027\027\t\005, )0.5(\023\030\036\007\f\021\026\r\035\016\036\021 )]TJ 0 Tw T* (\f\024\002\024\005 \n\t\001\036\004\027\031\033 \024\002\024\035\024\004\ \022\031 \(\n\t\001\036\004\027\t\005 \f\035\024\005\);)Tj 0.5 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )233( )]TJ EMC 1 0 Td (\023\016\021\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\220\b\024\020\036\027\027\t\005, \220\021\024 \ \f\036\030\024\027\026\016 )Tj 0 Tw T* (\024\002\024\035\024\004\022\026.)Tj -0.041 Tw -1 -1.218 Td (\210\f\027\024\r\027\t\036 \220\027\007\024\f\024\027\024\020\030\026\235\ \017\004\036\f\022\017\036 \022\030\017\021\036\030\017\017 \007\035\016\ \017\027\021\030\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\n\031\030\026\035\034\027\t\b \024\002\030\026\024\r\026\027\017\005 \r\ \022\035\033\004\026\033\021 \220\b\024\020\036\027\027\024\f\021\034, \220\ \b\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\021\030\031\022\021\031\030\031 \017)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \017\f\b\024\007\017\021 \027\024\r\024\ \024\002\030\026)Tj 0 Tw (-)Tj 0.076 Tw T* (\024\r\026\027\017\036. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\024\027\024\020\030\026\235\017\017 \035\017\023\024\n\ \026 \024\023\030\036\007\036\035\016\036\021\f\016 )Tj -0.005 Tw T* [(\022\026\022 \017\027\021\036\027\f\017\r\027\024 \020\017\023\036\030\220\ \b\024\020\036\027\027\024\036, )0.5(\024\007\027\024\030\024\007\027\024\036 \024\002\030\026\024)]TJ 0 Tw (-)Tj 0.144 Tw T* [(\r\026\027\017\036, )0.5(\017\f\b\024\007\016\013\036\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.169 0 Td [(\021\030\036\021\034\036\020\024 )0.5(\(\023\024\007\f\035\017\017\f\021\024\020\024\) )0.6(\f\035\024\016 )]TJ ET q 42.52 570.6 209.764 166.408 re W n q /GS0 gs 209.7637708 0 0 167.523017 42.5196852 570.5821006 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.001 Tw 9 0 0 9 42.5197 559.7997 Tm [(\022\t\217\210\b\002\220 )0.5(4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\217\024\026\031\023\032 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 13.835 0 Td [(\240\027\f\031\026 )0.5(\024\021\027\023\027. )0.5(\035\022\033\031\026\020 )0.5(\025\022\024)]TJ 0 Tw (-)Tj -13.835 -1.2 Td (\200\031\030\t\212\027\235 \007\020\024\023\022 \030\021\027\025\020\030\ \006\020\023\022\033\027\032\024\023\025\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.304 Tw 0 -1.2 TD [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endopho)13(to. Ex)10(amination in white light. Lipoma )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the descending duodenum)Tj ET q /GS0 gs 212.5984234 0 0 170.3666824 42.5196877 346.5290695 cm /Im3 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.012 Tw 9 0 0 9 42.5197 335.619 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\025\030\031\203\031\023\031. \217\024\026\031\023\032 \021)Tj /Span<>> BDC ( )Tj EMC (\240\027\f\031\026 \024\021\027\023\027. \035\022\033\031\026\020 \024\022\ \b)Tj 0 Tw (-)Tj T* (\026\031\021\022\030\025\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.304 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endopho)13(to. Ex)10(amination in white light. Lipoma )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the sigmoid colon)Tj ET q /GS0 gs 212.5984234 0 0 170.1267366 42.51968 122.5883513 cm /Im4 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.18 Tw 9 0 0 9 42.5197 111.77 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\217\024\026\031\023\032 \021)]TJ /Span<>> BDC ( )Tj EMC [(\240\027\f\031\026 \024\021\027\023\027. )0.5(\205\022\026\033\023\031\026 )]TJ 0 Tw T* (\253\033\031\030\r\213\n\022\273 \f\022\033\031\026\013 \020\025\023\032\ \020\f\017\025\031\b\031 \031\023\030\027\f\020 \255\027\f\r\030\n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.131 Tw T* [(F)-16(igure )0.6(6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Endopho)13(to. )0.6(Ex)10(amination )0.6(in )0.5(white )0.6(light. )0.6(\253Cushion\273 )]TJ 0 Tw T* (sign of)Tj /Span<>> BDC ( )Tj EMC (antral lipoma)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 504.7145 56.0378 Tm (171)Tj ET endstream endobj 88 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;% ##   u!"1Qu2356Rr#AUaqSTbt $%&'()*4789:BCDEFGHIJVWXYZcdefghijsvwxyz?UU9Efb|z!4^Ff'Efb|z!D.:3B31>hO/D#3B31>hF`#\FB31>hO/D#0ئo0vSk@{arbZ>f'Efb|z!4^Ff'E}H2U*qsҊ*k9V4꤇וofys~Q۫'9-BN`M2"%b9>XqP:p*=IqGM< G&U*qsҊ$  /36_ͣ$`(D 9I >!|0h,riIX)$8`B!!a.(  Јl))FণSOKk OWJ@v &IS"@!@Cd^(JTE ) L ;v Cd*2htHIc'bZ;!%dPrǹL =v~aCJG.{)Mp@aVlSspR^4{mCJ6lq۱JyTi :rrYMMui5y R/ayvٲR݅hly\͒"B. it,'!F)jӇW>H<:ӌEX6𨦥Jٹd,%F8z$͗hI UVY Ђ 6Km4%c U*qsҊ^Gs}*d{d\۪,qEscoNHUo[Τx-\6Tc;v$Bk!CF+zBh/U3Gu#!XJXM21 Ra6؍t4/FA (dH!L F q˴5!WK:cQ1C}bazzT 3R:J7DE" j.u2Zr-D\ 8dì/n] za}.sLM8L0#R{DmL e@D|4O6UKD@rs@8; "P6Rle,2c}okv̛wB !kAYfƶ+7rj]mGM< G&U*qsҊ^Gs}*d{\۪,qEscoNH9(CJPab"1 KG(Ɩ; {*Om:!H}O'0Dlq)q(n Hq˴5"H1c2َ RhM% #E)ccXL#@4髪Y, #3ZW7@crQ@B& ĞpYtH69#!\wԇr.80T!q A$ytǧ<>ݧ.3&xZwYk4ɩwFꆍ4%c U*qsҊ@``qb w{Wp w{WDzI%r`+c *1a'<}+5|uRCkʌ{}b91 "#ٻiRʜADJb* DPP&1tasH;:fgT k&s^u "0BCiNc R`%۸cVK]H훤,E$Skٴ#2hw (s6":݄PmaWK]L[E(n.ckJsyKAt=nq$j@0w.^%EXO+/H(2Hc VO*5"1K}ܻj<&;qbK\x;Xl'8P&IH`($^0! :jέ"M`pƩ.8l0DLSIc4;A0)E \@B:ӇW>H7Ny}5ۦ/^(mqeZP])e^)e^ zbY9bb/N')P<ʽqFB4Vn.M di4NlBۅ. mh mh mh mh#3 d)YS1Tk cwGM< G&U*k`dzQZxZ*{:3#8Z*{:3#8Z*{:3#aOSU<"d51f(*AX+Z$LsR5$2ysqJẄ́T ""8aηIE)H(vjH@Gp5hL T&LsJ"%dUzBh$2H@Gu07E2y,H*ͪ+UȢ@Lc5 5M2,eڻrD*H K,q إ)6 †fWU˟QTU0 $!p)B zJe/tu T,`)@16DGzZkL#%P*\DcZ^5O :ĞmT$#}ZL9{b ISjF\Y,BqB:׉.'Ry0 tL8ɪp(&ئ59[պ1(37o%rAEWJ "A8@cEtHGm@-PeS:eDmskFLHpA3%),#[GS -T}=nGS -T}=nGS -T}=n zL%&E~f;DgHLS\C2U/k ݟs8u{8g8i1?3ZG}OÌ֑s8u{8g8_KXКQUNR&BA1aJ}qGKmX7;HPF5am4jʜdT1::'r4[t^rݝS,tBNe8HP VgY(U&z"ٱe%Y3 Kq#n"AOL֫˙% 9t"Q:*&9@  :=3b~E9TT٥IL'+fa 1Tt«+KR.\őQ"\p.b^ 4d%tfIH &@FׁYĹ ]-REQ" s9l[{V o+M$ЊJC,r GT͖3yc)"*C@@kF!1D@."6 A=)DƗ;ljJc P";Aݖg ^w6TԊvG+UY{1̊)@ len89RI"(q(\L"6ףTSnV#vVJG1P0a :fdβHT(ׄ`䓤*J0td~sJPDJ Gn.ddβ*SLsHF":Ig 2E"̢Ba"PƎ9v{~,iMz4H+"E2~}k[DG\궓 *K(#'8"#`׆^xRwẕᇅ(x^xRwfr:fNJ W**j bayOj<bEY Tt(FݤnE/`@sEQp&.8 kx4=+*irG5P !YY+)3v2"" a Bۂ2MSRx̡w"qda^h;j !G D%N-3*oR`qaÊ؂ڼ"Jp”{{MS\| x̬9B-aiY2}8`vMrR0Ȧu@%(ǿBFl,NvdΖ+׶ \dU*qsҊb5I$`ͩR1RZ!߱a19!Lc7T P(EzgKԭ̩Hj*T!`1"%\a;vHoI,JjPB&0<5B+9ېʪL&9d(k ԵJڥ8q*xIL[E!JU "a-!ֲ=|PA QCP 1Gtwf~ΰM)uTSL;vy֮^3&:먑$Q9 #IHJ&Joݚ\%٢gq+v!X(m5=|b=8,.95P"UM28 1J6SBڌo\PsVq,Y4QL(qb&0˰%-4|uREUo[Τx͛3LV]cL;@JdCONX,UjWr R&S Q0ZԌRYš`6̘a،vW,]̩I) He#;b@YiJ$SJjO2[HcPp$T(m{Xi2U0e,@W(%bu"*JT{4`d>b6rd. *xħ> r ۔)0@` ƺ_[RWrLPpvM2`y6pV@L`0@Db;EWUc#,_O5A%S>#lPּj[LT],F3. xhi4wC1bڷTF$zoL>8LQ!^nSU0&QĦ=Z$ea'vWZ]f<U*qsҊѕjd0 &`=lWm/S)aFQҵA5r(aıul&fPㄠ& oJ=ӄ"¢2p F(v;2`̙fI[k 4[$vbi/Y7NN 78$L (`"6)GXX>B^uL@)&8J"Me =+vƠp u}-*~i-$RӚeʙÄTdPb `lRzyW02b). a0v#i THXc5f6!SEMs XvH˗g$L[b+@L6 mldze|iJ?C,YJ8AĢ! 1`װmJqZ7pM'H@lR#C筥~lTa.#`\HPO.tu^?hVLjAM2 @T]ONg L݄]+0&c 1X6!F_zFhs'g;(@L;Aq Gv9Lx ?B,W{sGK'saM;6݉YqaⱰ:iRTLZLNĒ@)ba)=q'59Lw &t@>@!B(b\IR439k3=|I0Hs p `zOIu7Q092˕jE5S "`s'1TRio' )*$CR1bhɶ۵h,A(˜0kuIT4)4ɪ|Nk`sFE$s8XQMf:605RiNs/En$Nٙ8x@DJKNj%UFL\2dfb1=6YD4$KR5F<>g-lķ^qUr:?˙}M7j'lXx@A5.Pѱo:K”dU PֽFp³:Zɔbf#ĈbDP2*e1 ڎD]ֈuf@"e19 qi*SMtkk`CwZ?Hpd_1e.b8CV7+?n5ꄋ Uu4&EpQ( h."I)*:Ff֤ȳD8]b#`dKvN+(dRlCA9[FیEdAFMT^N騒7]S7;4UƑ.U/:|tą*qF 4唂i5 \$.3lPۘ"m])2q (1!lE q׾A\{9B%ҤWC)LT mqi\*(f<@J#\@,SA.@Z(،$P!;Q lqL1!l[_^xNͪY3VrteRzUNSؠ fmbҭD[x͑LGɩaDxUfMnQI4PΕ*V2s8kDc·wMAI)@g(UDԾ^\In,#w:SK>z! 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\023\030\017\027\026\022\026\ \n \035\017\023\024\n )Tj T* (\024\021\027\024\f\016\021\f\016:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.169 Tw 1 0 Td (\253\217\t\214\212\003\002\214 \212\002\240\210\230\220\t\273)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf (\227 \235\024\030\n\017\030\024\r\026\027\017\036 \031\020\035\031\002\035\ \036)Tj 0 Tw (-)Tj 0.129 Tw -1 -1.218 Td (\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\036\030\b\027\024\f\021\017 \027\024\r\024\024\002\030\026\024\ \r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\026\r\035\017)Tj 0 Tw (-)Tj 0.252 Tw 0 -1.218 TD (\r\026\027\017\017 \017\027\f\021\030\031\n\036\027\021\024\n \(\f\023\036\ \006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 98%, \004\031\r)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 40%\) [24];)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.31 Tw 1 0 Td [(\253\217\t\214\212\003\002\214 )0.5(\230\004\003\006\004\273)]TJ /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 8.634 0 Td [(\227 )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\f\r\016\036\005 )0.5(\n\036\032\007\031 )]TJ 0.579 Tw -9.634 -1.218 Td (\035\017\023\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\024\005, \030\ \036\026\035\017\031\033\013\036\036)Tj 0 Tw (-)Tj 0.238 Tw T* (\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\022\006\017\017 \f\035\017\017\f\021\024\005 \002\017\024\023\ \f\017\005\027\t\n\017 \013\017\023\006\026\n\017. )Tj -0.055 Tw T* (\215\024\035\024\032\017\021\036\035\034\027\t\005 \030\036\031\035\034\ \021\026\021 \b\026\030\026\022\021\036\030\017\031\036\021\f\016 \235\024\ \030\n\017\030\024)Tj 0 Tw (-)Tj 0.192 Tw 0 -1.218 TD (\r\026\027\017\036\n \021\030\036\031\020\024\035\034\027\024\005 \253\023\ \026\035\026\021\022\017/\001\026\021\030\026\273 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 )Tj 0 Tw 0 -1.218 TD (\024\002\024\035\024\004\022\017 \027\026\007 \023\024\r\036\030\b\027\024\ \f\021\034\033 \027\024\r\024\024\002\030\026\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([25];)Tj 0 -1.218 TD (\251)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.121 Tw 1 0 Td [(\253\217\t\214\212\003\002\214 \002\206\b\004\202\t\230\r\n\002\217\235\ )0.5(\202\t\006\004\273)]TJ /Span<>> BDC ( )Tj EMC /T1_0 1 Tf (\227 \r\t\f\r\024\002\024\032)Tj 0 Tw (-)Tj 0.171 Tw -1 -1.218 Td (\007\036\027\017\036 \032\036\035\021\024\005 \032\017\030\024\r\024\005\ \021\022\026\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \f\021\031)Tj 0 Tw (-)Tj 0.121 Tw T* (\023\036\027\004\026\021\024\005 \002\017\024\023\f\017\017, \017\027\024\ \020\007\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\020\024 \024\023\024\030\024\032\027\036\027\017\016\ )Tj 0 Tw T* (\035\017\023\024\n\t [25].)Tj -0.083 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \b\026\030\026\022\021\036\030\027\t\b \023\ \030\017\027\026\022\024\r \007\035\016 \007\026\027)Tj 0 Tw (-)Tj 0.054 Tw T* (\027\024\020\024 \021\017\023\026 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005, \r\t\016\r\035\016\036\n\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.077 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \n\036\021\024\007\ \024\r \r\017\031\026\035\017\026\006\017\017, \023\024\f\021\026\027\024\ \r\022\026 )Tj -0.018 Tw T* (\024\022\024\027\004\026\021\036\035\034\027\024\020\024 \007\017\026\020\ \027\024\026 \035\017\023\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031)Tj 0 Tw (-)Tj 0.111 Tw T* (\004\026\036\r \r\024\n\024\032\027\026 \021\024\035\034\022\024 \023\024\ \f\035\036 \220\027\007\024\f\024\027\024\020\030\026\235\017\004\036\f\022\ \024\020\024 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 [24].)Tj /T1_1 1 Tf 0 -2.436 TD (\231\b\240\002\217\002\b\002\n\006\004\226\t\201\r\217\220\004\235 \217\r\ \214\t\002\003\t\220\004)Tj /T1_0 1 Tf 0.058 Tw 0 -1.218 TD [(\215\030\017 )0.5(\220\027\007\024\f\024\027\024\020\030\026\235\017\017 )0.6(\f\021\036\027\022\017 )0.6(\023\024\035\024\020\024 )0.5(\024\030\020\026\027\026 )0.5(\023\024\035\031\004\026\036)]TJ 0 Tw (-)Tj 0.054 Tw T* (\n\024\036 \023\024\f\035\024\005\027\024\036 \017\024\002\030\026\032\036\ \027\017\036 \f\024\024\021\r\036\021\f\021\r\031\036\021 \026\027\026\021\ \024\n\017)Tj 0 Tw (-)Tj 0.12 Tw T* (\004\036\f\022\017\n \f\035\024\016\n, \024\023\030\036\007\036\035\016\036\ \n\t\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n )Tj 0.194 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017 \(\f\035\017\017\f\021\026\016\ \024\002\024\035\024\004\022\026, \n\t\001\036\004\027\026\016 \023\035\ \026)Tj 0 Tw (-)Tj 0.075 Tw T* (\f\021\017\027\022\026 \f\035\017\017\f\021\024\005 \024\002\024\035\024\ \004\022\017, \023\024\007\f\035\017\017\f\021\t\005 \f\035\024\005, \n\ \t)Tj 0 Tw (-)Tj T* (\001\036\004\027\026\016 \024\002\024\035\024\004\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\024\027\026\016 \024\002\024\035\024\004\022\026\).)Tj 0.416 Tw T* (\232\017\f\035\024 \r\017\031\026\035\017\017\030\031\036\n\t\b \f\035\ \024\201\r \026\r\017\f\017\021 \024\021 \004\026\f\021\024)Tj 0 Tw (-)Tj 0.39 Tw T* [(\021\t )0.5(\031\035\034\021\030\026\r\031\022\024\r\024\020\024 )0.5(\f\022\026\027\017\030\024\r\026\027\017\016: )0.6(\004\036\n )0.5(\r\t\001\036 )0.5(\004\026)]TJ 0 Tw (-)Tj 0.181 Tw T* (\f\021\024\021\026, \021\036\n \002\024\035\034\001\036 \007\036\021\026\ \035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\201\r \n\024\032\027\024 \031\r\017\007\036\021\034. )Tj 0.341 Tw T* (\230\f\023\024\035\034\024\r\026\027\017\036 \f\021\026\027\007\026\030\ \021\027\t\b \031\035\034\021\030\026\r\031\022\024\r\t\b \220\027\007\024\ )Tj 0 Tw (-)Tj 0.386 Tw T* [(\f\022\024\023\024\r )0.5(\(\022\024\027\r\036\022\f\027\t\b )0.6(\017\035\017 )0.5(\030\026\007\017\026\035\034\027\t\b\) )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.462 0 Td (\004\026\f\021\024\021\024\005 )Tj 0.331 Tw -18.462 -1.218 Td (7,5\22612 \204\206\006 \023\024\r\024\035\016\036\021 \r\017\031\026\035\ \017\017\030\024\r\026\021\034 \022\026\022 \021\022\026\027\017 )Tj 0.021 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\n\017 \240\025\221 \(\004\026\f\021\024\021\ \026 7,5\22610 \204\206\006\), \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\031 )Tj 0.062 Tw T* (\f\026\n\024\020\024 \024\030\020\026\027\026 \(\004\026\f\021\024\021\026\ 10\22612)Tj /Span<>> BDC ( )Tj EMC (\204\206\006\), \023\030\036\007\f\021\026\r\035\036\027\027\031\033 )Tj 0 Tw T* (\023\016\021\017\f\035\024\005\027\024\005 \017\035\017 \007\036\r\016\021\ \017\f\035\024\005\027\024\005 \f\021\030\031\022\021\031\030\024\005 [2\ 6].)Tj 0.825 Tw T* (\212\035\016 \007\017\026\020\027\024\f\021\017\022\017 \017\027\021\030\ \026\n\031\030\026\035\034\027\t\b \024\002\030\026\024\r\026\027\017\005\ )Tj 0.152 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027\026\022\024\r\024\005 \220\235\235\036\022\021\017\r\027\ \024\f\021\034\033 \n\024\020\031\021 \017\f\023\024\035\034\024\r\026\021\ \034)Tj 0 Tw (-)Tj 0.155 Tw T* (\f\016 \022\026\022 \030\026\007\017\026\035\034\027\t\005, \021\026\022\ \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\r\036\f\022\f\027\t\005 \220\b\024\220\027\007\024\f\022\024\ )Tj 0 Tw (-)Tj 0.065 Tw T* (\023\t [27]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n )0.5(\024\021\007\036\035\036\027\017\017 )]TJ 0.054 Tw T* (\022\026\022 \022\024\027\r\036\022\f\027\024\020\024, \021\026\022 \017\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\026\035\034\027\024\020\024 \031\035\034\021\030\026\r\ \031\022\024\r\024\020\024 )Tj 0.288 Tw T* (\220\027\007\024\f\022\024\023\026, \027\036\f\022\024\035\034\022\024 \031\ \007\024\002\027\036\036 \017\f\023\024\035\034\024\r\026\021\034 \030\026\ \007\017)Tj 0 Tw (-)Tj 0.279 Tw T* (\026\035\034\027\t\005 \220\b\024\220\027\007\024\f\022\024\023, \023\024\ \f\022\024\035\034\022\031 \220\021\024\021 \026\023\023\026\030\026\021\ \017\n\036)Tj 0 Tw (-)Tj 0.23 Tw T* (\036\021 \021\024\030\006\036\r\031\033 \024\023\021\017\022\031, \017\027\ \026\004\026\035\034\027\024 \023\030\036\007\027\026\027\026\004\036\027\ \007\035\016 )Tj -0.027 Tw T* (\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \006\036\035\036\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\007\026\036\021 \001\017\030\024\022\017\n\017 \031\021\ \024\004\027\016)Tj 0 Tw (-)Tj 0.113 Tw T* [(\033\013\017\n\017 )0.6(\r\024\n\024\032\027\024\f\021\016\n\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.032 0 Td [(\024\027\024\005 )0.6(\024\f\n\024\021\030\026, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.504 0 Td [(\021\024\n )0.5(\004\017\f)]TJ 0 Tw (-)Tj 0.212 Tw -18.537 -1.218 Td (\035\036 \007\024\023\023\035\036\030\024\r\f\022\024\005 \024\006\036\027\ \022\024\005 \022\030\024\r\024\021\024\022\026. \025\024\027\r\036\022\f\ \027\t\005 )Tj 0.453 Tw T* (\220\b\024\220\027\007\024\f\022\024\023 \017\f\023\024\035\034\031\036\ \021\f\016 \023\036\030\r\t\n \(\017 \036\007\017\027\f\021\r\036\027)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\t\n\) \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \f\035\031\004\026\036, \036\f\035\017 \026\023\035\026\027\017\ \030\024\r\026\027\024 \r\t\023\024\035\027\036\027\017\036 )Tj ET q 303.307 570.597 209.764 166.411 re W n q /GS0 gs 209.7637708 0 0 167.523017 303.3071013 570.5795982 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.034 Tw 9 0 0 9 303.3071 559.7972 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\025\030\031\203\031\023\031. \217\024\026\031\023\032 \021)Tj /Span<>> BDC ( )Tj EMC (\240\027\f\031\026 \024\021\027\023\027. \035\022\033\031\026\020 \025\022\ \255)Tj 0 Tw (-)Tj 0 -1.2 TD (\025\027\b\032\r\030\025\031\b\031 \031\023\030\027\f\020 \033\022\212\027\ \021\031\030\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.04 Tw T* [(F)-16(igure )0.5(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. )0.5(Ex)10(amination )0.5(in white light. )0.5(Lipoma )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0 Tw T* [(low)12(er thoracic esophagus)]TJ ET q 303.307 346.527 212.598 170.366 re W n q /GS0 gs 212.5984234 0 0 170.3666824 303.3070679 346.5266281 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.05 Tw 9 0 0 9 303.3071 335.6197 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\025\030\031\203\031\023\031. \217\024\026\031\023\032 \021)Tj /Span<>> BDC ( )Tj EMC (\240\027\f\031\026 \024\021\027\023\027. \035\022\033\031\026\020 \020\025\ )Tj 0 Tw (-)Tj T* (\023\032\020\f\017\025\031\b\031 \031\023\030\027\f\020 \255\027\f\r\030\ \n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.044 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13.1(to. Ex)9.9(amination in white light. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0 Tw T* (antrum of)Tj /Span<>> BDC ( )Tj EMC (the stomach)Tj ET q /GS0 gs 212.5984234 0 0 170.1267366 303.3070984 122.5889921 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.001 Tw 9 0 0 9 303.3071 111.7701 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\217\024\026\031\023\032 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 13.835 0 Td [(\240\027\f\031\026 )0.5(\024\021\027\023\027. )0.5(\035\022\033\031\026\020 )0.5(\025\022\024)]TJ 0 Tw (-)Tj -13.835 -1.2 Td (\200\031\030\t\212\027\235 \007\020\024\023\022 \030\021\027\025\020\030\ \006\020\023\022\033\027\032\024\023\025\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.304 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. Ex)10(amination in white light. Lipoma )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the descending duodenum)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8276 56.0378 Tm (170)Tj ET endstream endobj 306 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,^""  !1AQaq"2#Bb $%&'()*3456789:CDEFGHIJRSTUVWXYZcdefghijrstuvwxyz!1AQa"q2B$Rr #%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz?RI%tЄ$I!BI$!U%WzЮю HzV77VK´4 kF^ҾH.E +Kd\%q;*NTNƽ#@zCk-wh;Mպk=gQ0exf4ڷNhF6oQe8?p^ 0m&^&IC` 5+@<Mh`ݛMFunz]=f:CP ) zL0LpE !B 1\hS &0Bd!RI4PbRꬄ! jYFZetn82D6R)B2FIw N(tAL$!QiID{q驩"OT.ӧ/MA^i]:Wc>I:9I$v*]HI$B(BI$!I$B!RI%tЄ$I!Bp 0*Jewt$pH s;V!nCVM< *U4UDH$X3%I^oV,}[ti:Z/v;giEm1a "L;ԠCK1I9PhсH ˳9otw-#pj ;2jPoGv<UJO"ZvRk W*NԚ.BU jZQD$ʄB)ÆiĚҊ$M6**IBi9ѷ$(\e B֪x:DQJB)KH8faR$BbNQ<4p BnT$ qk\dXSbB:/qGHZ0|nO2zB'<zLIs3Λ. 2Wd!R ܁ wђڙqQ@֦BI%HLd)hq:Atԩ!D;HgfykB Nհ)8@5PKYBNxQA)_jm"% T)ISDL"*HB$l@`&LQ0\ (`^ڣM)e.!B5j_5/7Ic4FeF(#%huT)d*@2ţe~$kBʄALdtT-Ztuk2zq8l9'j@vw#6U!H[Nට[tuu_[tU/  *^ɯ$-#NV+Kqa'OO "o`rOE$ςcd.|*2*cK!fF)45S$Iˋ\*UTI! 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Re)11(vie)11(w\))]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 711.1159 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc 0.166 Tw 8 0 0 8 42.5596 731.2159 Tm [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.171 Tw 14.347 0 Td [( V)33(aler)-37(iia I. Ryabtsev)16.1(a, P)114(. Her)-40(tsen Moscow Oncology R)21(esearch Institute \(MORI\), 2nd Bo)13(tkinsky p)46(roezd, 3, )]TJ 0.023 Tw -14.352 -1.2 Td [(Moscow)52(, 125284, R)22(ussia; e-mail: v)16(aler)-42.9(yappv@gmail.com)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 05.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 05.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 651.7618 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc -0.035 Tw 10 0 0 10 42.5197 627.4058 Tm (\214\017\023\024\n\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\ \027\201\027\027\024\036 \017\027\021\030\026\n\031\030\026\035\034)Tj 0 Tw (-)Tj 0.003 Tw 0 -1.218 TD (\027\024\036 \027\024\r\024\024\002\030\026\024\r\026\027\017\036 \n\036\ \036\027\b\017\n\026\035\034\027\024\020\024 \023\030\024\017\f\b\024\032\ \007\036)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\017\016, \n\036\007\035\036\027\027\024 \030\026\r\017\r\026\033\013\ \036\036\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\030\024\r\024\005 \021\022\026\027\017 [1]. )Tj 0.017 Tw T* (\212\026\027\027\t\036 \024\023\031\b\024\035\017 \n\024\020\031\021 \r\f\ \021\030\036\004\026\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \024\030\020\026\027\026\b, )Tj 0.106 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\n \021\ \030\026\022\021\036 \(\240\025\221\), )Tj 0.052 Tw T* (\024\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\240\025\221 \035\017\023\024\n\t \007\017\026\020\027\024\f\021\017\030\ \031\033\021\f\016 \027\026\004\017\021\036\035\034\027\024 )Tj 0.059 Tw T* [(\030\036\032\036, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\017\b )0.5(\007\024\035\033 )0.5(\023\030\017\b\024\007\017\021\f\016 )0.5(\024\022\024\035\024 )0.5(4\2265% \024\021 )0.5(\024\002\013\036\020\024 )]TJ 0 Tw T* (\004\017\f\035\026 \007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\ \t\b \024\002\030\026\024\r\026\027\017\005 [2].)Tj 0.025 Tw T* [(\221\026\022, \002\024\035\034\001\017\027\f\021\r\024 )0.5(\035\017\023\024\n \240\025\221 )0.5(\024\002\027\026\030\031\032\017\r\026\033\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj 0.055 Tw T* (\f\021\024\005 \022\017\001\022\036 \(60\22675%\))Tj /Span<>> BDC ( )Tj EMC [(\227 \027\026\017\002\024\035\036\036 \021\017\023\017\004\027\t\n )0.5(\n\036\f\021\024\n )]TJ 0.329 Tw T* (\035\024\022\026\035\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\030\020\026\027\036 \016\r\035\016\033\021\f\016 \r\024\ \f\b\024\007\016\013\026\016 )Tj 0.072 Tw T* [(\024\002\024\007\024\004\027\026\016 )0.5(\(45%\) \017)]TJ /Span<>> BDC ( )Tj EMC 8.348 0 Td [(\f\017\020\n\024\r\017\007\027\026\016 )0.5(\(30%\) \022\017\001\022\017, )0.5(\021\024\020\007\026 )]TJ 0.187 Tw -8.348 -1.218 Td (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\f\b\024\007\016\013\036\005 \024\002\024\007\024\004\027\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\024-\024\002\024\007\024\004)Tj 0 Tw (-)Tj 0.068 Tw T* (\027\024\005 \022\017\001\022\026\b \024\027\017 \r\f\021\030\036\004\026\ \033\021\f\016 \030\036\032\036 \(\023\030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (15% )Tj 0.08 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (9% \f\035\031\004\026\036\r, \f\024\024\021\r\036\021\f\021\r\036\027\027\ \024\) [3]. \025\030\024\n\036 \021\024\020\024, \024\023\017)Tj 0 Tw (-)Tj 0.31 Tw T* (\f\026\027\t \036\007\017\027\017\004\027\t\036 \f\035\031\004\026\017 \035\ \017\023\024\n\026\021\024\026 \021\024\035\f\021\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.348 Tw T* [(\022\017, \022\024\021\024\030\t\005 \n\024\032\036\021 \023\030\024\016\ \r\035\016\021\034\f\016 )0.5(\027\036\f\023\036\006\017\235\017\004\036\f\022\024\005 )]TJ 0.271 Tw T* [(\f\017\n\023\021\024\n\026\021\017\022\024\005 )0.5(\253\024\f\021\030\024\020\024 \032\017\r\024\021\026\273 \017)]TJ /Span<>> BDC ( )Tj EMC (\n\026\f\022\017\030\024\r\026\021\034\f\016 )Tj 0.316 Tw T* (\023\024\007 \007\030\031\020\017\036 \026\002\024\035\036\r\026\027\017\ \016 [30]. \200\021\024\030\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 )Tj 0.096 Tw T* (\024\030\020\026\027\024\n, \020\007\036 \035\024\022\026\035\017\031\033\ \021\f\016 \035\017\023\024\n\t, \016\r\035\016\036\021\f\016 \021\024\027\ \022\026\016 )Tj 0.047 Tw T* (\022\017\001\022\026 \(\024\022\024\035\024 30%\). \222\024\020\035\026\f\ \027\024 \035\017\021\036\030\026\021\031\030\027\t\n \007\026\027\027\t\ \n, )Tj 0.085 Tw T* (\002\024\035\034\001\026\016 \017\b \004\026\f\021\034 \235\024\030\n\017\ \030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\r\007\024\001\027\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.169 Tw T* (\022\036 \(\007\024 20%\), \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 )Tj 0.041 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.791 0 Td [(\021\024\013\036\005 )0.6(\022\017\001\022\026\b )0.6(\017\b )0.6(\007\024\035\016 )0.6(\027\036\r\036\035\017\022\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.457 0 Td [(\f\024\f\021\026\r\035\016\036\021 )0.6(\035\017\001\034 )]TJ 0.293 Tw -15.249 -1.218 Td (10% [4]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\036, \007\024\f\021\031\023\027\024\005 )Tj 0.43 Tw T* (\024\f\n\024\021\030\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\024\235\026\020\024\020\026\f\021\030\024\007\031\024\007\036\027\024\ \f\022\024\023\017\017 \(\233\206\212\222\), )Tj 0.116 Tw T* (\024\023\031\b\024\035\017 \004\026\013\036 \024\023\030\036\007\036\035\ \016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\036\036 \027\017\f\b\024\007\016\013\036\005 \004\026\f\021\017 )Tj -0.01 Tw T* (\(D2\) [5,6]. \200)Tj /Span<>> BDC ( )Tj EMC (\023\017\013\036\r\024\007\036 \035\017\023\024\n\t \r\t\016\r\035\016\033\ \021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (10\22612% )Tj 0.035 Tw T* (\023\026\006\017\036\027\021\024\r, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \024\027\017, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024\ , \035\024\022\026)Tj 0 Tw (-)Tj -0.007 Tw T* (\035\017\031\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\001\036\005\027\024\n \017\035\017 \r\036\030\b\027\036\020\030\031\007\ \027\024\n \024\021\007\036\035\026\b [6,7]. )Tj 0.069 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \035\017\023\024\n\t \f\024\f\021\026\r\035\ \016\033\021 \n\036\027\036\036 1% \024\021 \r\f\036\b \027\024)Tj 0 Tw (-)Tj -0.043 Tw T* (\r\024\024\002\030\026\024\r\026\027\017\005 \220\021\024\020\024 \024\030\ \020\026\027\026, \017)Tj /Span<>> BDC ( )Tj EMC (\r \002\024\035\036\036 \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (75% \f\035\031)Tj 0 Tw (-)Tj 0.154 Tw T* (\004\026\036\r \030\026\f\023\024\035\026\020\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\030\026\035\034\027\024\n \024\021\007\036\035\036 [5,6]. \025\ \026\022 )Tj 0.032 Tw T* [(\023\030\026\r\017\035\024, \035\017\023\024\n\t \240\025\221 \030\026\f\ \023\024\035\026\020\026\033\021\f\016 )0.5(\017\027\021\030\026\n\031\030\026\035\034\027\024 )]TJ 0.21 Tw T* (\(90\22695%\), \f\031\002\f\036\030\024\027\024\036 \030\026\f\023\024\035\ \024\032\036\027\017\036 \027\026\002\035\033\007\026\036\021\f\016 )Tj 0 Tw T* (\027\026\004\017\021\036\035\034\027\024 \030\036\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (5\22610% \f\035\031\004\026\036\r [10].)Tj 0.024 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \023\026\021\024\ \020\036\027\036\021\017\004\036\f\022\017\005 \n\036\b\026\027\017\n \235\ \024\030)Tj 0 Tw (-)Tj 0.112 Tw T* (\n\017\030\024\r\026\027\017\016 \035\017\023\024\n \024\030\020\026\027\ \024\r \240\025\221 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\t \030\017\f\022\026 \017\b )Tj 0.29 Tw T* (\030\026\r\017\021\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\f\017\b \023\024\030 \007\024\f\021\024\r\036\030\027\024 \027\036 \031\ \f\021\026\027\024\r\035\036\027\t. )Tj 0.019 Tw T* [(\210\007\027\026\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.963 0 Td [(\035\017\021\036\030\026\021\031\030\036 )0.6(\024\023\017\f\026\027\026 )0.5(\026\022\024\027\024\n\036\030\027\024\f\021\034 )0.6(\031\r\036\035\017)]TJ 0 Tw (-)Tj -0.024 Tw -3.963 -1.218 Td (\004\036\027\017\016 \004\017\f\035\026 \r\t\016\r\035\016\036\n\t\b \035\ \017\023\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\030\036)Tj 0 Tw (-)Tj 0.092 Tw T* (\027\017\036\n \017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\n \027\026\002\024\030\036 \017\n\017 \n\026\f\f\t \ \021\036\035\026 [11]. )Tj -0.002 Tw T* (\025\026\022 \023\030\026\r\017\035\024, \220\021\024\021 \021\017\023 \027\ \024\r\024\024\002\030\026\024\r\026\027\017\005 \024\030\020\026\027\024\ \r \240\025\221 )Tj 0.603 Tw T* (\027\036 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \022\035\017\ \027\017\004\036\f\022\024\005 \f\017\n\023\021\024\n\026\021\017\022\024\ \005, )Tj 0.006 Tw T* (\023\030\024\021\036\022\026\036\021 \002\036\f\f\017\n\023\021\024\n\027\ \024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\027\026\030\031\032\017\r\026\036\021\f\016 \f\035\031\004\026\005\ \027\024 )Tj 0.076 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\024\n \220\027\007\024\f\022\024\023\017\004\036\f\ \022\024\n \024\002\f\035\036\007\024\r\026\027\017\017 [6,9]. )Tj 0.224 Tw 23.244 57.237 Td (\210\007\027\026\022\024 \027\026\035\017\004\017\036 \024\023\031\b\024\ \035\017 \002\024\035\034\001\017\b \030\026\n\036\030\024\r \n\024\032\ \036\021 )Tj 0.536 Tw T* (\023\030\024\016\r\035\016\021\034\f\016 \030\016\007\024\n \027\036\f\023\ \036\006\017\235\017\004\036\f\022\017\b \f\017\n\023\021\024\n\024\r. )Tj 0.02 Tw T* (\203\026\023\030\017\n\036\030, \035\017\023\024\n\t \023\017\013\036\r\024\ \007\026 \n\024\020\031\021 \b\026\030\026\022\021\036\030\017\024\r\026\ \021\034)Tj 0 Tw (-)Tj 0.326 Tw T* (\f\016 \007\017\f\235\026\020\017\036\005, \030\036\020\031\030\020\017\021\ \026\006\017\036\005 \f\024\007\036\030\032\017\n\024\020\024, \002\024\035\ \034\033 )Tj 0.12 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(\220\023\017\020\026\f\021\030\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 11.506 0 Td [(\021\026\022\032\036 )0.5(\022\030\024\r\024\021\036\004\036\027\017\016\n\017, )]TJ 0.008 Tw -12.333 -1.218 Td [(\030\026\r\017\r\026\033\013\017\n\017\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.144 0 Td [(\r\017\007\031 )0.5(\017\255\016\r\035\036\027\017\016 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024)]TJ 0 Tw (-)Tj -0.037 Tw -8.144 -1.218 Td [(\035\024\004\022\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\r\036\030\b\027\024\f\021\017 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 )0.5([13]. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\035\024)Tj 0 Tw (-)Tj 0.055 Tw T* (\022\026\035\017\026\006\017\017 \035\017\023\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \021\026\022\032\036 \n\024)Tj 0 Tw (-)Tj 0.27 Tw T* (\032\036\021 \027\026\002\035\033\007\026\021\034\f\016 \022\035\017\027\ \017\004\036\f\022\026\016 \022\026\030\021\017\027\026 \r\021\024\030\017\ \004\027\024\020\024 )Tj 0.079 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\030\024\b\024\007\017\n\024\f\021\017 \023\030\024\f\r\036\021\ \026 \r\r\017\007\031 \036\020\024 )Tj 0.006 Tw T* [(\f\021\036\027\024\017\030\024\r\026\027\017\016 )0.6(\022\030\031\023\027\t\n )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\036\n )0.5([11,12]. )]TJ 0.317 Tw T* (\230\027\021\030\026\n\031\030\026\035\034\027\t\036 \035\017\023\024\n\t\ \021\024\027\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.221 Tw T* (\017\n\036\033\021 \f\b\024\032\031\033 \022\035\017\027\017\004\036\f\022\ \031\033 \022\026\030\021\017\027\031: \022\026\022 \023\030\017\r\017\035\ \024, )Tj -0.027 Tw T* (\023\026\006\017\036\027\021\t \023\030\036\007\255\016\r\035\016\033\021\ \032\026\035\024\002\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\022\024\n\235\024\030\021 \r)Tj /Span<>> BDC ( )Tj EMC (\220\023\017)Tj 0 Tw (-)Tj 0.307 Tw T* [(\020\026\f\021\030\017\017, )0.5(\027\026\035\017\004\017\036 )0.6(\023\030\017\027\026\022\024\r )0.6(\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ )]TJ 0.024 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\036\n\017\017 [16]. \025\030\024\n\036 \021\024\020\024, \035\017\ \023\024\n\026 \n\024)Tj 0 Tw (-)Tj 0.063 Tw T* (\032\036\021 \017\n\036\021\034 \253\023\f\036\r\007\024\027\024\032\022\ \031\273)Tj /Span<>> BDC ( )Tj EMC (\227 \007\031\023\035\017\022\026\021\031\030\031 \f\035\017\017\f\021\024\ \005 )Tj 0.148 Tw T* (\024\002\024\035\024\004\022\017, \023\030\036\007\026\033\013\031\033 \036\ \005 \023\024\007\r\017\032\027\024\f\021\034 [10,11]. \221\026\022, )Tj 0.189 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\002\017\030\024\r\026\027\017\017 \024\023\031\b\024\ \035\017, \027\026\023\030\017\n\036\030, \004\036\030\036 \023\017)Tj 0 Tw (-)Tj 0.153 Tw T* (\035\024\030\017\004\036\f\022\017\005 \022\026\027\026\035, \n\024\032\036\ \021 \030\026\r\017\021\034\f\016 \024\002\f\021\030\031\022\006\017\016\ \036\020\024 )Tj 0.223 Tw T* (\023\030\024\f\r\036\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \f\023\036\006\017\235\017\004\036\f\022\024\ \005 \022\035\017\027\017\004\036\f\022\024\005 )Tj 0 Tw T* (\f\017\n\023\021\024\n\026\021\017\022\017 [5,17,18].)Tj /T1_5 1 Tf 0 -2.436 TD (\231\b\240\002\217\220\002\212\t\201\r\217\220\004\235 \217\r\214\t\002\003\ \t\220\004)Tj /T1_4 1 Tf 0.281 Tw 0 -1.218 TD [(\233\027\007\024\f\022\024\023\017\004\036\f\022\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 \(\r \004\026\f\021\027\024\f\ \021\017, )0.5(\233\206\212\222 )]TJ 0.232 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\022\024\035\024\027\024\f\022\024\023\017\016 )0.5(\(\025\222\)\) \026\027\017\n\026\036\021 )0.5(\024\007\027\024 \017)]TJ /Span<>> BDC ( )Tj EMC 18.028 0 Td (\022\035\033\004\036\r\t\b )Tj 0.179 Tw -18.028 -1.218 Td (\n\036\f\021 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \017\027\021\030\026\n\031\030\ \026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026)Tj 0 Tw (-)Tj 0.162 Tw T* (\027\017\005 \024\030\020\026\027\024\r \032\036\035\031\007\024\004\027\ \024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026, \r\022\ \035\033\004\026\016 )Tj 0.027 Tw T* (\035\017\023\024\n\t. \233\021\024\021 \n\036\021\024\007 \023\024\r\024\ \035\016\036\021 \024\023\030\036\007\036\035\017\021\034 \n\026\022\030\ \024\f\022\024)Tj 0 Tw (-)Tj 0.006 Tw T* [(\023\017\004\036\f\022\017\036 \b\026\030\026\022\021\036\030\017\f\021\017\ \022\017 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\r\t\023\024\035)Tj 0 Tw (-)Tj -0.027 Tw T* [(\027\017\021\034 )0.5(\007\024\023\024\035\027\017\021\036\035\034\027\t\036 )0.6(\017\027\f\021\030\031\n\036\027\021\026\035\034\027\t\036 )0.6(\021\036\f\021\t )0.6(\007\035\016 )0.5(\017\b )]TJ 0 Tw T* (\r\036\030\017\235\017\022\026\006\017\017.)Tj 0.085 Tw T* (\230\027\021\030\026\n\031\030\026\035\034\027\t\036 \027\024\r\024\024\002\ \030\026\024\r\026\027\017\016 \r\f\036\b \023\024\035\t\b \024\030\020\ \026)Tj 0 Tw (-)Tj 0.132 Tw T* (\027\024\r \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\ \024\020\024 \021\030\026\022\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\022\024\n \024\f\n\024\021\030\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\036\035\024\n \f\r\036\021\036 \007\036\n\024\027\f\021\030\017\030\ \031\033\021 \f\b\024\032\017\036 )Tj 0.216 Tw T* (\023\030\017\027\026\022\017. \210\002\t\004\027\024 \021\026\022\017\036\ \024\002\030\026\024\r\026\027\017\016 \017\n\036\033\021 \023\024\035\ \031)Tj 0 Tw (-)Tj 0.215 Tw T* [(\f\235\036\030\017\004\036\f\022\031\033 )0.6(\017\035\017 )0.5(\023\024\035\031o\ro\017\007\027\031\033 )0.6(\235\024\030\n\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.534 0 Td (\023\024\022\030\t\021\t )Tj 0.486 Tw -18.534 -1.218 Td (\027\036\017\n\036\027\201\027\027\024\005 \f\035\017\017\f\021\024\005\ \024\002\024\035\024\004\022\024\005 [21]. \210\007\027\024\005 )Tj -0.035 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.142 0 Td [(\027\026\017\002\024\035\036\036 )0.5(\f\023\036\006\017\235\017\004\036\f\022\017\b )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022 )0.6(\035\017\023\024\n )0.5(\016\r)]TJ 0 Tw (-)Tj 0.068 Tw -1.142 -1.218 Td (\035\016\036\021\f\016 \017\b \032\036\035\021\024\r\026\021\t\005 \024\021\ \021\036\027\024\022, \022\024\021\024\030\t\005 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.146 Tw T* [(\035\017\004\017\036\n )0.6(\026\007\017\023\024\006\017\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 8.633 0 Td [(\227 )0.5(\032\017\030\024\r\t\b )0.6(\022\035\036\021\024\022, )0.5(\253\023\030\024\f\r\036\004\017)]TJ 0 Tw (-)Tj 0.008 Tw -8.633 -1.218 Td [(\r\026\033\013\017\b\273 )0.6(\004\036\030\036 )0.5(\f\035\017\017\f\021\031\033 )0.5(\024\002\024\035\024\004\022\031 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.956 0 Td (\007\024\f\021\026\021\024\004\027\024\005 )Tj 0 Tw -16.956 -1.218 Td (\017\027\f\031\235\235\035\016\006\017\017 \r\024\007\031\b\024\n \(\217\ \017\f. 1\2265\) [7,20].)Tj 0.246 Tw T* (\212\035\016 \024\023\030\036\007\036\035\036\027\017\016 \022\024\027\f\ \017\f\021\036\027\006\017\017 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \r\026)Tj 0 Tw (-)Tj 0.249 Tw T* (\017\n\024\f\r\016\017 \f\024 \f\035\024\016\n\017 \f\021\036\027\022\017\ \024\030\020\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 )Tj 0.555 Tw T* [(\023\030\026\022\021\017\022\036 )0.5(\001\017\030\024\022\024 )0.5(\023\030\017\n\036\027\016\036\021\f\016 )0.5(\017\027\f\021\030\031\n\036\027\021\026\035\034\027\026\016 )]TJ 0.141 Tw T* [(\253\023\026\035\034\023\026\006\017\016\273 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \017\b )0.5(\002\017\024\023\f\017\005)]TJ 0 Tw (-)Tj 0.246 Tw T* (\027\t\b \013\017\023\006\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\). \233\021\024 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\t\b \023\030\024\f\021\t\b )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td 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S`%?r >| __ZN}yew„ 褺 lۙ|ԯ> 7đ˶%YU;j[ =ʪGF̫S"ch]J2/=97B VcAvIIpp}~x5ZAcD|$:rֶ.#5]0~Ե?0nD4J|~Gk/wGQUvnqM7Nn7{X+ Sp[$ߩ*aNI^5.3gTi@t/?]g} [H7ߐ/y7 Gt<}bEe(U |Yȋ$Z!2_mZZF(hʊf-qOmwOާ \P*>Zc0L>Vs[4_̐ '4ʯ $A qo3ps>\0Ia6x$f9j,Kxz9c)5XY[Q$c]V/ᢿQ_AQ\y|nG;؛nӽb-Rch\M4bP񾢘E \}Ms2Í(YϨ1jck`B7#>и97c`LWOC n{.5 /!:N|\i+mr:#/Laeo3ʈDՈF?aȺ@ց}I4&$';ts۬(F[o{ 0"&\bz0TR]X_c$xj&W>=ψvv$А r]thRz N q6Of*M^ЮiKߓK.v`".; \KNI"EtPq q&[dKA3:I,,q, 9"D>8]tNx;#7e?׷Wyj"Nx&%U^kYDܜy$:>^cMʞqɋ]kI`.J[8т(;~"3ښV)+>B_TnYQ?ـͤ+p: ܯJ~Mz0BaU?X?jȀ2`wGާ !|)ŬЯV(xpue\ܺ L&4Zm&MA#{N՛ShkYĕ="We8)$ ZNC.՝G6zes>C~ٍ\0X]ܵ_PNYsd0sQ,- e-g |BQp#;xT!66*~cD(4lsדtdSvвYHÛi8l G)$/JC/sGQfˬJ_HؼA~'lD><K! 'n,#cqZ)-kD<]9=  V$[x-X!~9rI8&aq!NϦ;a{k-,ڵ+\|`!gmlW\Φ3nӂGE*]edkKc6.H x+x 5stu`B9DsnN`IAm$I$?6v64Q~cV=gb'0{_K?Jm)ٜ{*:vy&zE@ɬ /v* oAATlkK|soo5nOlb.#%xKt-`bQF0y?"n &E/h8ڂ\0A(=փ)0j2zYB rUdAWrt;9ctދL+Rs0 O13/ O^p&MXm,}*6‘eˤR Z,iQO/ @J9Mo~U~+WRx/;tweyV}v  |މnuj])>7QWJ1sQE7mYPq8މCk9yݙG[h(U))_GlQE/29䩣iBuODM!X9kТ1^Oco] S;z|"|goi4j]]KVSuk1ѓ.0)-lf*%=KFD RTs"r.jx,So8> g][ޓuz,[ngvޝqi p83R[pJD)RUGχв T!BF:Kmp'R-Dى7*SR!C7/5(9`n'!wLiPL4jZ6hD#Evea, "کQ IhUhS2/楝/&kP*NKfVBViK|wza` Ev'\RY_Na&:-e=7tݻ?jƃxJ -&ə&$-f-AM"R)IVY=e:rLWm%8U32H ߸–~IT8F歱B#Ksc 5#1#Yը&wGz.:i8nbY밬5Q4l&zr#~?䇨@N(=Q6wF獷;\ C6A_Ȏ_ā%Qe( x\^lg;Y/cS!#8}p9挸~ע\45|&WGX"_ai n$ cԛz``ev|~M:z_OzX8%;!sl]w4ĹDT _8Ym]@Kx *կ47IJw4;Iېe[(F1 *AOJ>%rj컱Kԧpq(_j{p;fK!?h+2gP[x'۵QWp No1b ډqPPa>vJw4 0)yDˏkW'C,Zݼm۳Z O0klf1OG%ewgC}?_vWWz Z.2QtK!bN xp䟄 WtT\m1n 1 N"W5USH~uc%G%][tc F&)F 4ʬޕIޣW2a. GQ*#%=2G:cX[L 5弛Q95iq43@ou_NPy4k*ޢOa VIoC7:OUKTEe/όq-̌aKkpC[IduHeDp!C.=l(\~%F2#1 NM9R9ɾ=_\@O6yh߁q4<# yaKsBv:5q*3qƪ&G%|uH&Z  VHHόI)l.ZR ֲ?_OtLqcjE _aae ǒhc;ώ8=`4AwˬI,O:Z[c+O}ӽNGSD>)lDZ֚P1kNRᅾTWϫ HEd,:TTO?@,< 6:ݼo͌,0::՛!W{)Ifwŏ?EUN*V,rVh VoX|uz&%O I)IЮHI^e%68]trd8@6K74ZwLW]s3A:IY @5F2/2fL$6z4lI{liV09 ta}IMTPa #v!EZ(5gFnbn¬bm: r-5}Wt и#P,REJĻr s8_$ !'] ӷӋnՠt^v?{pڻkwEEZqºBZ"T endstream endobj 303 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 743.0544 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 743.0544 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 696.2466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 696.2466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 154.7623 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 154.7623 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 107.9545 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 107.9545 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.033 Tc 0.168 Tw 8 0 0 8 70.9061 731.2159 Tm [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_1 1 Tf 0.023 Tc 0.173 Tw 9.34 0 Td ( \207\031\030\007\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\222., \202\005\030\026\023\036\021\016\027)Tj /Span<>> BDC ( )Tj EMC (\203.\202., \200\026\035\017\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\230.\217., \206\r\024\007\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\024\030\024\035\036\r)Tj /Span<>> BDC ( )Tj EMC (\206.\202., \215\026\022\035\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\016\002\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC [(\200.\230.,)23( )]TJ 0.017 Tc -0.034 Tw -9.345 -1.2 Td (\202\020\036\005\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC 4.217 0 Td [(\203.\200., )0.6(\206\031\f\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 5.277 0 Td [(\213.\200., )0.6(\230\r\026\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.476 0 Td [(\230.\230., )0.6(\025\024\030\032\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.292 0 Td [(\230.\224., )0.6(\214\024\b\n\026\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.775 0 Td [(\204.\204., )0.6(\203\017\022\024\035\026\005\004\031\022)]TJ /Span<>> BDC ( )Tj EMC 7.725 0 Td [(\221.\200., )0.6(\215\036\030\235\017\035\034\036\r)]TJ /Span<>> BDC ( )Tj EMC 7.068 0 Td [(\230.\207., )0.6(\215\017\030\024\020\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.063 0 Td [(\222.\222., )0.6(\222\017\007\024\030\017\027)]TJ /Span<>> BDC ( )Tj EMC 5.862 0 Td [(\200.\200.,)17( )]TJ 0.023 Tc 0.09 Tw -54.754 -1.2 Td (\222\021\026\030\004\036\027\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\212. \212\017\026\020\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \035\017\023\024\n \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ \(\215\030\026\022\021\017\004\036\f\022\017\036)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026\006\017\017.)Tj /Span<>> BDC ( )Tj EMC (\210\002\024\030)Tj /Span<>> BDC ( )Tj EMC [(\035\017\021\036\030\026\021\031\030\t\).)23( )]TJ /T1_2 1 Tf -0.023 Tw 0 -1.2 TD (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_1 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (167\226180. https://doi.org/10.33878/2073-7556-2026-25-1-167-180)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0.023 Tw 18 0 0 18 114.6616 670.0774 Tm [(Diagnosis and tr)31(eatment of\022)-23.3(lipomas of\022)-23.3(th)11(e digestiv)12.1(e )]TJ 1.853 -1.167 Td [(tr)21(act \(Pr)21.1(actical r)31(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 624.5734 Tm [(Mikhail\022)-23.2(S.\022)-23.3(Bur)31(dy)10(uk)11.1(ov)]TJ 8.162 0 0 8.162 189.3404 629.2354 Tm [(1)69(,2,3)]TJ 0.023 Tw 14 0 0 14 207.9088 624.5734 Tm [(, Nair)21(a\022)-23.2(A)-31(.\022)-23.3(Hayr)21(apet)-19.9(y)21(an)]TJ 0 Tw 8.162 0 0 8.162 342.5848 629.2354 Tm (3)Tj 0.023 Tw 14 0 0 14 347.2208 624.5734 Tm [(, Ildar\022)-23.2(R.\022)-23.3(V)31(aliulin)]TJ 0 Tw 8.162 0 0 8.162 441.115 629.2354 Tm (4)Tj 14 0 0 14 445.7509 624.5734 Tm (, )Tj -26.777 -1.143 Td [(Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(Gv)10(o)15(z)21(de)11(v)]TJ 8.162 0 0 8.162 180.7592 613.2354 Tm (5)Tj 0.023 Tw 14 0 0 14 185.3951 608.5734 Tm [(, Grigor)-30.9(y\022)-23.3(A)-31(.\022)-23.3(K)41(or)20(ole)11(v)]TJ 0 Tw 8.162 0 0 8.162 301.4937 613.2354 Tm (6)Tj 0.023 Tw 14 0 0 14 306.1296 608.5734 Tm [(, Ox)11(ana\022)-23.2(V)61.9(.\022)-23.2(P)20(aklina)]TJ -0.127 Tc 0.127 Tw 8.162 0 0 8.162 412.3864 613.2354 Tm [(7,)-127(8)]TJ 0 Tc 0 Tw 14 0 0 14 423.2335 608.5734 Tm (, )Tj -25.169 -1.143 Td [(V)31(aleriia\022)-23.2(I.\022)-23.3(R)20(y)21(abtse)11(v)10(a)]TJ 8.162 0 0 8.162 185.8269 597.2354 Tm (9)Tj 0.023 Tw 14 0 0 14 190.4629 592.5734 Tm [(, Natalia\022)-23.2(V)62(.\022)-23.3(Ageykina)]TJ 0 Tw 8.162 0 0 8.162 312.679 597.2354 Tm (4)Tj 0.023 Tw 14 0 0 14 317.3149 592.5734 Tm [(, Ev)10(genia\022)-23.2(V)62(.\022)-23.3(Guse)11(v)10(a)]TJ 0 Tw 8.162 0 0 8.162 430.67 597.2354 Tm (4)Tj 0.023 Tw 14 0 0 14 435.3059 592.5734 Tm [(, Ilia\022)-23.2(I.\022)-23.3(Iv)10(anov)]TJ 0 Tw 8.162 0 0 8.162 512.7509 597.2354 Tm (4)Tj 14 0 0 14 517.3868 592.5734 Tm (, )Tj -31.894 -1.143 Td [(Irina\022)-23.2(Y)40(u.\022)-23.3(K)41(or)20(zh)11(e)11(v)10(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 173.9136 581.2354 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 185.2343 576.5734 Tm [(, Mak)11(sim\022)-23.2(M.\022)-23.3(Lokhmatov)]TJ 0 Tw 8.162 0 0 8.162 319.5468 581.2354 Tm [(6,1)75(0)]TJ 0.023 Tw 14 0 0 14 335.4543 576.5734 Tm [(, T)40(atiana\022)-23.2(V)62(.\022)-23.3(Nik)11(olaich)11(uk)]TJ 0 Tw 8.162 0 0 8.162 468.8704 581.2354 Tm (4)Tj 14 0 0 14 473.5063 576.5734 Tm (, )Tj -28.76 -1.143 Td [(Ily)21(a\022)-23.3(B.\022)-23.3(P)10(er)-10(f)-21(ile)11(v)]TJ -0.212 Tc 0.212 Tw 8.162 0 0 8.162 150.8547 565.2354 Tm (11)Tj 0 Tc 0.023 Tw 14 0 0 14 158.3964 560.5734 Tm [(, Ser)31(gey\022)-23.2(S.\022)-23.3(Pir)20(ogov)]TJ 0 Tw 8.162 0 0 8.162 266.2213 565.2354 Tm (9)Tj 0.023 Tw 14 0 0 14 270.8573 560.5734 Tm [(, V)31(asiliy\022)-23.2(V)62(.\022)-23.3(Sidorin)]TJ 0 Tw 8.162 0 0 8.162 373.3752 565.2354 Tm (4)Tj 0.023 Tw 14 0 0 14 378.0112 560.5734 Tm [(, Denis\022)-23.2(D.\022)-23.3(Star)31(ch)11(enk)11(ov)]TJ 0 Tw 8.162 0 0 8.162 504.5396 565.2354 Tm (4)Tj 5.83 0 0 5.83 70.8661 546.2342 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 542.9042 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education, Ministr)-31(y of\022)-23.3(Health of\022)-23.3(th)11(e Russian F)20(eder)21(ation )]TJ -0.331 -1.2 Td [(\(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69.1(, Building 1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 522.2342 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 518.9042 Tm [(F)20(eder)21(al Net)-19.9(w)11(ork of\022)-23.3(Clinics \232Eur)20(oonco)-41.9(\233 \(Dukh)11(ov)10(sk)11(oy Lane, 22B, Moscow)22(, 1)212(1)113(5)127(1)138(9)125(1)69(, Russia\);)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 510.2342 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 506.9042 Tm [(Moscow Multidisciplinar)-30.8(y Clinical and Diagnostic Center named af)-30.9(ter S.P)94(.\022)-23.3(Botkin, Depar)-20(tment of\022)-23.3(Health of\022)-23.3(th)11(e )]TJ -0.331 -1.2 Td [(Cit)-20(y of\022)-23.2(Moscow \(2nd Botkinsky Pr)20(oe)21(z)21(d, 5, Moscow)22.1(, 1)125(2)23(5)35(2)35(8)34(4, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 486.2343 Tm (4)Tj 0.023 Tw 10 0 0 10 74.1775 482.9043 Tm [(Medsi Clinical Diagnostic Center \(CDC\) on Kr)21(asnay)21(a Pr)31(esny)21.1(a Str)31(eet \(Kr)21(asnay)21.1(a Pr)31(esny)21(a\022)-23.2(st., 1)112(6, Moscow)22.1(, )]TJ -0.331 -1.2 Td [(1)125(23)46(2)69(42, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 462.2343 Tm (5)Tj 0.023 Tw 10 0 0 10 74.1775 458.9043 Tm [(Dav)-21(y)10(dov)10(sky Cit)-19.9(y Clinical Hospital, Depar)-20(tment of\022)-23.3(Health of\022)-23.3(th)11(e Cit)-20(y of\022)-23.3(Moscow \(Y)50(au)21(z)10(skay)21(a\022)-23.2(st., 1)212(1/6, Moscow)22(, )]TJ -0.331 -1.2 Td [(1)75(09)35(2)69(40, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 438.2344 Tm (6)Tj 0.023 Tw 10 0 0 10 74.1775 434.9044 Tm [(National Medical Resear)31.1(ch Center for Childr)31(en\236)63.1(s Health, Ministr)-30.9(y of\022)-23.3(Health of\022)-23.2(th)11(e Russian F)19.9(eder)21.1(ation )]TJ -0.331 -1.2 Td [(\(Lomonosov)10.1(sky Pr)20(ospect, 2, bld.\022)-23.3(1)69(, Moscow)22(, 1)212(1)138(999)125.1(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 414.2344 Tm (7)Tj 0.023 Tw 10 0 0 10 74.1775 410.9044 Tm [(Moscow Clinical Resear)31.1(ch Center named A)-31(.S.\022)-23.3(Loginov)21.1(, Depar)-20(tment of\022)-23.3(Health of\022)-23.3(th)11(e Cit)-20(y of\022)-23.2(Moscow )]TJ -0.331 -1.2 Td [(\(Nov)10(ogir)31(ee)11(v)10(skay)21.1(a\022)-23.3(st., 1)69(, bld.\022)-23.2(1)69(, Moscow)22(, 1)212(1)212(1)212(1)125(23, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 390.2345 Tm (8)Tj 0.023 Tw 10 0 0 10 74.1775 386.9045 Tm [(National Medical Resear)31.1(ch Center of\022)-23.3(Sur)31(ger)-31(y named A)-31(.V)62(.\022)-23.3(Vishne)11(v)10(sky)31(, Ministr)-31(y of\022)-23.2(Health of\022)-23.3(th)11(e Russian )]TJ -0.331 -1.2 Td [(F)20(eder)21(ation \(Bolshay)21(a Serpukh)11.1(ov)10(skay)21(a\022)-23.3(st., 2)46(7)127(, Moscow)22(, 1)212(1)113(509)35(3, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 366.2346 Tm (9)Tj 0.023 Tw 10 0 0 10 74.1775 362.9046 Tm [(P)94(.A)-31(.\022)-23.3(Her)-19.9(tsen Moscow Oncology Resear)31.1(ch Institute\022)-23.2(\230 br)21(anch of\022)-23.2(th)11(e National Medical Resear)31.1(ch Radiological )]TJ -0.331 -1.2 Td [(Centr)31(e, Ministr)-30.9(y of\022)-23.3(Health of\022)-23.2(th)11(e Russian F)20(eder)21(ation \(2nd Botkinsky Pr)20(oe)21(z)21(d, 3, Moscow)22.1(, 1)125(2)23(5)35(2)35(8)34(4, Russia\))]TJ 0 Tw ( )Tj -0.075 Tc 0.075 Tw 5.83 0 0 5.83 70.8661 342.2346 Tm (10)Tj 0 Tc 0.023 Tw 10 0 0 10 77.0517 338.9046 Tm [(Sech)11(enov Fir)20.1(st Moscow State Medical Univ)12.1(er)20(sit)-20(y \(Sech)11(enov Univ)12(er)20(sit)-19.9(y\), Ministr)-31(y of\022)-23.2(Health of\022)-23.2(th)11(e Russian )]TJ -0.619 -1.2 Td [(F)20(eder)21(ation \(T)20(r)10(ubetskay)21(a\022)-23.2(st., 8, Building 2, Moscow)22.1(, 1)212(1)138(90)25(48, Russia\))]TJ 0 Tw ( )Tj -0.212 Tc 0.212 Tw 5.83 0 0 5.83 70.8661 318.2347 Tm (11)Tj 0 Tc 0.023 Tw 10 0 0 10 76.253 314.9047 Tm [(Br)21(anch Oncology Center \0231 of\022)-23.3(th)11(e Moscow Cit)-20(y Hospital named S.S.\022)-23.3(Y)40(udina, Depar)-19.9(tment of\022)-23.2(Health of\022)-23.3(th)11(e Cit)-20(y )]TJ -0.539 -1.2 Td [(of\022)-23.3(Moscow \(Z)21(agor)20(odnoy)10(e Sh)11(osse, 1)112(8A)-31(, Building 7)127(, Moscow)22(, 1)212(1)138(7)127(1)113(5)35(2, Russia\))]TJ /T1_2 1 Tf 0.006 Tc 0.136 Tw 9 0 0 9 119.0551 284.4008 Tm [(Lipoma is a common benign subepithelial neoplas)33(m of mesench)12(ymal or)-37(igin that dev)13(elops slow)10(ly from adipose)6( )]TJ 0.106 Tw 0 -1.111 TD [(tissue )0.6(in )0.6(the )0.5(g)12(astrointestinal )0.5(tract. )0.6(Most )0.5(lipomas )0.6(occur )0.5(in )0.6(the )0.5(colon, )0.5(accounting )0.5(for )0.5(60-75% )0.6(of )0.5(cases, )0.6(with )0.5(less)6( )]TJ 0.076 Tw T* [(freq)14(uent occur)-16(rences in the s)33(mall intestine, esophagus, and stomach. Diagnosis is typically made thro\ ugh endo)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.094 Tw T* [(scopic e)-15(x)10(amination, while endosonog)14(raph)12(y can p)46(rovide more specif)-43(ic infor)-14(mation. In endosonog)14(raphic imaging,)6( )]TJ 0.018 Tw T* [(lipomas appear as homog)12(eneous, h)12(yperechoic masses or)-37(iginating from the submucosa \(third layer\). If the lipoma)6.1( )]TJ 0.046 Tw 0 -1.111 TD [(g)14(rows or becomes malignant, additional tests such as forceps biopsy)42(, step biopsy)42(, or f)-43(ine needle aspiration under)6( )]TJ -0.027 Tw 0 -1.111 TD [(endoscopic ultrasound guid)26(ance can be per)-34(for)-14(med for mor)-18(phological v)13(er)-37(if)-43(ication. T)56(reatment is recommended if the)6( )]TJ -0.016 Tw T* [(lipoma causes sym)16(p)13(toms lik)17(e pain, obstruction, or bleeding, or if it e)-15(xceeds 2 centimeters in size. F)12(or asym)16(p)13(tomatic)6( )]TJ 0.025 Tw T* [(lipomas, obser)-42(v)16(ation p)46(ro)13(tocols may in)11(v)13(olv)13(e regular endoscopic assess)33(ments based on size and location to monitor)6( )]TJ 0.023 Tw T* [(for an)11(y chang)12(es.)6.1( )]TJ /T1_0 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 179.1315 Tm [(KEYW)22(ORDS:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( lipoma, dig)12(estiv)13(e tract, upper endoscop)12.1(y)42(, endosonog)14.1(raph)12(y)42(, mor)-18(phological diagnosis)]TJ /T1_0 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_0 1 Tf 0.031 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.3(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.5(A)37.5(T)-24.4(I)-1.3(ON:)]TJ /T1_1 1 Tf 0.017 Tc -0.035 Tw 6.323 0 Td [( B)-6.6(u)-7.5(r)-18.1(d)-20.5(y)-21.4(u)-9.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-26.9(S)-9.5(.)-23.5(, H)-4.3(a)-14.9(y)-32.2(r)-30.7(a)-8.8(p)-24.7(e)-22.2(t)-50.9(y)-24.2(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.8(.)-23.9(A)-22.9(.)-23.5(, V)3.8(a)-11.3(l)-16.7(i)-3.5(u)-8.3(l)-16.7(i)-3.1(n)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.R)-21.3(.)-23.5(, G)-6.9(v)-15.4(o)-7.9(z)-15.3(d)-15.3(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)-23.9(A)-22.9(.)-23.5(, K)-11.1(o)-11.8(r)-15.8(o)-15.6(l)-23.6(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(G)-11.5(.)-23.9(A)-22.9(.)-23.5(, P)-10.3(a)-11.1(k)-17.3(l)-16.7(i)-3.1(n)-7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)40.7(V)39.7(.)-23.5(, R)-30.3(y)-24.2(a)-18.2(b)-22.7(t)-48.9(s)-22.9(e)-15.7(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-9.7(I)-10.3(.)-23.4(, A)-8.4(g)-14.4(e)-20(y)-21.9(k)-41.1(i)-3.1(n)-7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.7(.)40.6(V)39.7(.)-23.5(,)17( )]TJ 0.023 Tc 0.021 Tw -6.328 -1.2 Td [(G)-11.2(u)-21.9(s)-22.9(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)40.6(V)39.7(.)-23.5(, I)11.7(v)-28.4(a)-7.6(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-9.8(I)-10.3(.)-23.5(, K)-11.1(o)-11.9(r)-42.9(z)-12.6(h)-15(e)-15.9(v)-28.3(a I)-10.3(.)51.6(Y)12.6(u)-9(.)-23.5(, L)-24.8(o)-15.1(k)-16.8(h)-6.2(m)-8.3(a)-18.2(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7(.)-7.3(M)-7.1(.)-23.5(, N)-13.5(i)-6.6(k)-3.7(o)-15.6(l)-37.8(a)-14.9(i)-5(c)-10.2(h)-7(u)-9.6(k)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)40.6(V)39.7(.)-23.5(, P)-4.2(e)-12.1(r)-56(f)-63(i)-7(l)-23.7(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.B)3.3(.)-23.5(, P)-34(i)-6(r)-15.8(o)-18.6(g)-10.2(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-26.9(S)-9.6(.)-23.5(, S)-1.4(i)-8.8(d)-11.1(o)-11.8(r)-56.4(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)40.6(V)39.7(.)-23.5(, S)-3.2(t)-36.8(a)-10.2(r)-11.7(c)-10.2(h)-15.1(e)-11.5(n)-8.8(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)1.4(D)16.4(.)23.1( )]TJ 0.015 Tc -0.035 Tw 0 -1.2 TD [(D)-30.2(i)-5(a)-10.6(g)-8.7(n)-11.8(o)-15.7(s)-26(i)-7.3(s a)-7.5(n)-14.3(d t)-30.6(r)-19(e)-12.9(a)-18.1(t)-25.9(m)-16.5(e)-11.4(n)-17.2(t o)-12(f)]TJ /Span<>> BDC ( )Tj EMC [(l)-16.6(i)-2.5(p)-22.1(o)-9.1(m)-8.2(a)-26.5(s o)-12(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26(h)-14.9(e d)-15.7(i)-6.6(g)-14.3(e)-22.7(s)-29.2(t)-46.1(i)-14.3(v)-18.6(e t)-30.7(r)-30.7(a)-11(c)-41.3(t \()4.3(P)-18.5(r)-30.7(a)-10.9(c)-41.4(t)-46.1(i)-4.9(c)-21.4(a)-11.3(l r)-18.9(e)-19(c)-6.4(o)-9.1(m)-6.1(m)-16.4(e)-11.4(n)-14.4(d)-9.2(a)-18.1(t)-46.1(i)-6.6(o)-9.1(n)-11.1(s)-15.4(. R)-6.6(e)-15.7(v)-51.6(i)-10.9(e)-12.4(w)19.7(\))10.5(. )]TJ /T1_2 1 Tf 0.025 Tc -0.025 Tw [(K)14(ol)3.7(op)2.5(r)3.2(o)3.6(k)-19.1(t)2.3(ol)3.7(o)-3.1(g)-13.1(i)6.8(a)5.9(.)]TJ /T1_1 1 Tf 0 Tc -0.02 Tw 47.732 0 Td [( 2)-23.8(0)-18.7(2)-10.7(6)5(;)-5(2)-16.3(5)-14(\()22.8(1)29.4(\):)6.1(1)-2.3(6)-13.1(7)20.8(\226)35.9(1)-17.3(8)-38.3(0)-8.3(. )]TJ 0.023 Tc 0.024 Tw -47.732 -1.2 Td [(\()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.8(2)-1.4(5)-23.6(-)55.2(1)26.8(-)55.2(1)12.6(6)1.8(7)36.2(-)55.1(1)-2.5(8)-23.4(0)]TJ /T1_0 1 Tf 0.01 Tc 0.05 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.6(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_2 1 Tf 0 Tc 0.055 Tw 10.64 0 Td [( )0.5(\206\t\240\006\027\021\020 )0.6(\211\020\f\027\032\022\t )0.5(\002\b\031\032\027\021\025\020, )0.6(\215\001\002\217\002 )0.6(\022\026. )0.5(\004.\003.)]TJ /Span<>> BDC ( )Tj EMC 18.895 0 Td (\216\027\032\006\027\025\020)Tj /Span<>> BDC ( )Tj EMC 3.601 0 Td [(\227 )0.5(\203\022\f\022\020\f )0.6(\214\216\221\210 )0.5(\253\001\215\002\037 )0.5(\032\020\030\022\031\f\031\b\022\022\273 )0.6(\215\022\025\016\030\032\020\021\020 )0.6(\206\031\024\024\022\022, )]TJ 0.023 Tw -33.141 -1.2 Td (2-\235 \221\031\023\n\022\025\024\n\022\235 \033\032\031\027\016\030, \030\ .)Tj /Span<>> BDC ( )Tj EMC (3, \215\031\024\n\021\020, 125284, \206\031\024\024\022\t; e-mail: valer\ yappv@gmail.com)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 292.9053 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_0 1 Tf 0 Tw 9 0 0 9 73.5728 283.978 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8026 56.0378 Tm (168)Tj ET endstream endobj 295 0 obj [316 0 R] endobj 296 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-167-180)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 150.1359 695.3259 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022)-23.3(\020\004\225\004\t\n\004 \020\n\224\025\024 )]TJ 0.097 -1.105 Td [(\226\004\020\002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-9.9(\026)10.9(\017 )]TJ 0 Tw -4.434 -1.105 Td [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022)-23.2(\005\004\r)10(\025\024\004\t\202\017\n\n.\022)-23.2(\036\255\212\025\005\022)-23.3(\020\n\026)11(\004\005\017\026)-19.9(\002\005\217\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\006\002\005\202\206\r)10(\025\b\022)-23.2(\235.\001.)]TJ 8.162 0 0 8.162 131.5627 633.484 Tm [(1)69(,2,3)]TJ 0.023 Tw 14 0 0 14 150.131 628.822 Tm [(, \f\221\005\017\224\004\026\213\t\022)-23.2(\007.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 250.1397 633.484 Tm (3)Tj 0.023 Tw 14 0 0 14 254.7757 628.822 Tm [(, \021\017\020\n\002\020\n\t\022)-23.3(\030.\033)124(.)]TJ 0 Tw 8.162 0 0 8.162 344.3265 633.484 Tm (4)Tj 0.023 Tw 14 0 0 14 348.9624 628.822 Tm [(, \031)68(\b\025)21(\212\202\004\b\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 431.1631 633.484 Tm (5)Tj 14 0 0 14 435.799 628.822 Tm (, )Tj -28.091 -1.143 Td [(\037)31(\025\005\025\020\004\b\022)-23.3(\031)72(.\f)-30.9(.)]TJ 8.162 0 0 8.162 117.311 617.484 Tm (6)Tj 0.023 Tw 14 0 0 14 121.947 612.822 Tm [(, \034\017\r)-10(\020\n\t\017\022)-23.2(\036.\021.)]TJ -0.127 Tc 0.127 Tw 8.162 0 0 8.162 209.9857 617.484 Tm [(7,)-127(8)]TJ 0 Tc 0.023 Tw 14 0 0 14 220.8329 612.822 Tm [(, \033\213\255\004\b\017\022)-23.2(\021.\030.)]TJ 0 Tw 8.162 0 0 8.162 304.252 617.484 Tm (9)Tj 0.023 Tw 14 0 0 14 308.888 612.822 Tm [(, \f\013)10(\004\221\r\n\t\017\022)-23.2(\007.\021.)]TJ 0 Tw 8.162 0 0 8.162 399.2507 617.484 Tm (4)Tj 0.023 Tw 14 0 0 14 403.8867 612.822 Tm [(, \031)70(\002\016\004\b\017\022)-23.2(\240.\021.)]TJ 0 Tw 8.162 0 0 8.162 474.958 617.484 Tm (4)Tj 14 0 0 14 479.594 612.822 Tm (, )Tj -31.22 -1.143 Td [(\030\b\017\t\025\b\022)-23.2(\030.\030.)]TJ 8.162 0 0 8.162 117.1987 601.484 Tm (4)Tj 0.023 Tw 14 0 0 14 121.8346 596.822 Tm [(, \037)31(\025\005\226\004\b\017\022)-23.2(\030.\207.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 216.2161 601.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 227.5367 596.822 Tm [(, \035\025\220\024\017\026)11.1(\025\b\022)-23.3(\235.\235.)]TJ 0 Tw 8.162 0 0 8.162 327.6016 601.484 Tm [(6,1)75(0)]TJ 0.023 Tw 14 0 0 14 343.5091 596.822 Tm [(, \007\n\r)10(\025\020\017\221\225\002\r\022)-23.2(\032.\021.)]TJ 0 Tw 8.162 0 0 8.162 445.6598 601.484 Tm (4)Tj 14 0 0 14 450.2957 596.822 Tm (, )Tj -29.127 -1.143 Td [(\034\004\005\216\n\020\200\004\b\022)-23.2(\030.\006.)]TJ -0.212 Tc 0.212 Tw 8.162 0 0 8.162 135.3985 585.484 Tm (11)Tj 0 Tc 0.023 Tw 14 0 0 14 142.9401 580.822 Tm [(, \034\n\005\025\013)10(\025\b\022)-23.2(\001.\001.)]TJ 0 Tw 8.162 0 0 8.162 228.1514 585.484 Tm (9)Tj 0.023 Tw 14 0 0 14 232.7873 580.822 Tm [(, \001\n\202\025\005\n\t\022)-23.2(\021.\021.)]TJ 0 Tw 8.162 0 0 8.162 317.7463 585.484 Tm (4)Tj 0.023 Tw 14 0 0 14 322.3823 580.822 Tm [(, \001\026)11(\017\005\225\004\t\r)10.1(\025\b\022)-23.3(\201.\201.)]TJ 0 Tw 8.162 0 0 8.162 427.3192 585.484 Tm (4)Tj 5.83 0 0 5.83 42.5197 566.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 563.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \253\033\025\016\016\n\221\016\r\017\213 \024\004\202\n\ \n\t\016\r\017\213 \017\r\017\202\004\024\n\213 \t\004\224\005\004\005\217\ \b\t\025\013)10(\025 \224\005\025\216\004\016\016\n\025\t\017\020\200\t\025\013)10(\025 \025\255\005\017\212\025\b\017\t\n\213\273 )]TJ -0.331 -1.2 Td [(\235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020.\022)-23.3(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.3(\235\025\016\r\b\017,1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 542.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 539.1527 Tm [(\210\004\202\004\005\017\020\200\t\017\213 \016\004\026\200 \r)-10(\020\n\t\n\r \253\240\b\005\025\025\t\r)10(\025\273 \(\201\002)21(\220\025\b\016\r)10(\025\221 \224\004\005)-30.9(., \202.\022)-23.3(22\255, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)113(5)127(1)138(9)125(1)69(, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 530.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 527.1528 Tm [(\031\006)42(\227)31(\203 \253\235\025\016\r)10.1(\025\b\016\r\n\221 \024\t\025\013)10(\025\224\005\025\216\n\020\200\t\217\221 \r)-10(\020\n\t\n\r)10.1(\025-)-73(\202\n\017\013\t\025\016)-10(\026\n\225\004\016\r\n\221 \004\t\026\005 \n\024.\022)-23.3(\001.\034.\022)-23.3(\006\025\026\r\n\t\017 \201)21(\203\235\273 \(2-\221 )]TJ -0.331 -1.2 Td [(\006\025\026\r\n\t\016\r\n\221 \224\005\025\004\212\202, \202.\022)-23.3(5, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(2)23(5)35(2)35(8)34(4, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 506.4828 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 503.1528 Tm [(\037\201\003 \253\235\240\201\001\030 \t\017\022)-23.3(\037)20(\005\017\016\t\025\221 \034\005\004\016\t\004\273, \f\036 \253\235\240\201\ \001\030-2\273 \(\002\020.\022)-23.3(\037)20(\005\017\016\t\017\213 \034\005\004\016\t\213, \202.\022)-23.3(1)112(6, \013)62(.\022)-23.2(\235\025\016\r\b\017,1)125(23)46(2)69(42, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\016\016\n\213\))Tj ( )Tj 5.83 0 0 5.83 42.5197 482.4829 Tm (5)Tj 0.023 Tw 10 0 0 10 45.8311 479.1529 Tm [(\031\006)42(\227)31(\203 \253\031\037\006 \n\024.\022)-23.3(\030.\021.\022)-23.3(\201\017\b\217\202\025\b\016\r)10.1(\025\013)10(\025 \201)21(\203\235\273 \(\002\020.\022)-23.3(\027\002)31(\212\016\r\017\213, \202.\022)-23.2(1)212(1/6, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)75(09)35(2)69(40, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 470.4829 Tm (6)Tj 0.023 Tw 10 0 0 10 45.8311 467.1529 Tm [(\210\031)83(\f)41(\227 \253\007\017\n\025\t\017\020\200\t\217\221 \024\004\202\n\n\t\016\ \r\n\221 \n\016\016)-10(\020\004\202\025\b\017\026)11.1(\004\020\200\016\r\n\221 \004\t\026\005 \212\202\025\005\025\b\200\213 \ \202\004\026)11(\004\221\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n )]TJ -0.331 -1.2 Td [(\(\035\025\024\025\t\025\016\025\b\016\r\n\221 \224\005-)-42(\026, \202.\022)-23.3(2, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)138(999)125(1)69(, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 446.483 Tm (7)Tj 0.023 Tw 10 0 0 10 45.8311 443.153 Tm [(\031\006)42(\227)31(\203 \253\235\025\016\r)10.1(\025\b\016\r\n\221 \r)-10(\020\n\t\n\225\004\016\r\n\221 \t\017\002\225\t\217\221 \004\t\026\005 \ \n\024.\022)-23.3(\f)-30.9(.\001.\022)-23.3(\035\025\013\n\t\025\b\017\273 \201)21(\203\235 \(\002\020.\022)-23.3(\007\025\b\025\013\n\005\004\004\b\016\r\017\213, \202.\022)-23.2(1)68.9(, )]TJ -0.331 -1.2 Td [(\r)10(\025\005\224.\022)-23.3(1)69(, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)212(1)212(1)125(23, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 422.483 Tm (8)Tj 0.023 Tw 10 0 0 10 45.8311 419.153 Tm [(\210\031\006)42(\227 \253\007\017\n\025\t\017\020\200\t\217\221 \024\004\202\n\n\t\016\ \r\n\221 \n\016\016)-10(\020\004\202\025\b\017\026)11.1(\004\020\200\016\r\n\221 \004\t\026\005 \220\n\005\002\005\013\n\n \n\024\ .\022)-23.3(\f)-31(.\021.\022)-23.3(\021\n\204\t\004\b\016\r)10(\025\013)10(\025\273 \235\n\t\212\202\005\017\b\017 )]TJ -0.331 -1.2 Td [(\033\025\016\016\n\n \(\002\020.\022)-23.2(\006\025\020\200\204\017\213 \001\004\005\224\002)21(\220\025\b\016\r\017\213, \202.\022)-23.3(2)46(7)127(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)212(1)113(509)35(3, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 398.4831 Tm (9)Tj 0.023 Tw 10 0 0 10 45.8311 395.1531 Tm [(\235\025\016\r)10(\025\b\016\r\n\221 \t\017\002\225\t\025-\n\016\016)-10(\020\004\202\025\b\017\026)11.1(\004\020\200\016\r\n\221 \025\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \n\t\016)-9.9(\026\n\026)-20(\002)-20(\026 \n\024.\022)-23.3(\034.\f)-31(.\022)-23.3(\031)70(\004\005\004\t\017\022)-23.2(\230 \216\n\020\n\017\020 \210\031\006)42(\227 )]TJ -0.331 -1.2 Td [(\253\007\235\030\003 \005\017\202\n\025\020\025\013\n\n\273 \235\n\t\212\ \202\005\017\b\017 \033\025\016\016\n\n \(2-\221 \006\025\026\r\n\t\016\r\ \n\221 \224\005\025\004\212\202, \202.\022)-23.3(3, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125.1(2)22.9(5)35(2)35(8)34(4, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj -0.075 Tc 0.075 Tw 5.83 0 0 5.83 42.5197 374.4832 Tm (10)Tj 0 Tc 0.023 Tw 10 0 0 10 48.7052 371.1532 Tm [(\210\031)83(\f\036)20(\227 \021\036 \253\034\004\005\b\217\221 \235\025\016\r)10(\025\b\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-10(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026 \n\024\004\t\n \030.\235.\022)-23.3(\001\004\225\004\t\025\b\017\273 )]TJ -0.619 -1.2 Td [(\235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\001\004\225\004\t\ \025\b\016\r\n\221 \227)42(\t\n\b\004\005\016\n\026)11(\004\026\) \(\002\020.\022)-23.3(\032)30(\005\002\255\004\r\017\213, \202.\022)-23.3(8, \016)-10(\026\005)-31(.\022)-23.2(2, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)138(90)25(48, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj -0.212 Tc 0.212 Tw 5.83 0 0 5.83 42.5197 350.4832 Tm (11)Tj 0 Tc 0.023 Tw 10 0 0 10 47.9065 347.1532 Tm [(\210\n\020\n\017\020 \253\036\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \004\t\026\005 \0231 \031)80(\025\005\025\202\016\r)10(\025\221 \r)-10(\020\n\t\n\225\004\016\r)10(\025\221 \255\025\020\200\t\n\217 \n\024\004\t\n \001.\001.\022)-23.3(\207\202\n\t\017 \201)21(\203\235\273 )]TJ -0.539 -1.2 Td [(\(\203\017\013)10(\025\005\025\202\t\025\004 \204., \202.\022)-23.3(1)112(8\f)-52(, \016)-10(\026\005)-31(.\022)-23.3(7)127(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)212(1)138(7)127(1)113(5)35(2, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf -0.034 Tw 9 0 0 9 90.7087 316.6493 Tm (\037\036\035\034: \033\032\031\020\025\020\f\022\016\022\032\031\021\020\ \023\017 \204\025\030\031\024\n\031\033\022\007\027\024\n\022\027, \204\025\ \030\031\024\031\025\031\b\032\020\203\022\007\027\024\n\022\027 \033\032\ \022\016\025\020\n\022 \f\022\033\031\026 \031\032\b\020\025\031\021 \255\ \027\f\r\030\031\007\025\031-\n\022\213\027\007)Tj 0 Tw (-)Tj 0.002 Tw 0 -1.111 TD (\025\031\b\031 \023\032\020\n\023\020, \032\020\024\024\026\031\023\032\027\ \023\017 \022\200 \030\022\203\203\027\032\027\025\006\022\020\f\017\025\ \031-\030\022\020\b\025\031\024\023\022\007\027\024\n\022\027 \033\032\022\ \016\025\020\n\022, \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027, \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\020\025\022\022 \030\020\025\025\013\200 )Tj 0.212 Tw T* [(\026\022\032\031\021\031\235 )0.5(\f\022\023\027\032\020\023\r\032\013, \032\020\016\032\020\240\031\023\020\ \023\017 )0.5(\020\n\023\r\020\f\017\025\013\235 )0.5(\020\f\b\031\032\022\023\026 )0.5(\021\027\030\027\025\022\t \033\020\006\022\027\025\023\031\021 \024)]TJ /Span<>> BDC ( )Tj EMC 35.796 0 Td (\f\022\033\031\026\020\026\022 \255\027\f\r\030\031\007\025\031-)Tj 0.023 Tw -35.796 -1.111 Td (\n\022\213\027\007\025\031\b\031 \023\032\020\n\023\020.)Tj 0.261 Tw T* [(\217\205\001\217\211\001\201\036 )0.6(\004\217\035\217\234\036\001\002\226: )0.6(\f\022\033\031\026\013 )0.7(\t\021\f\t\005\023\024\t )0.6(\025\020\022\240\031\f\027\027 )0.7(\032\020\024\033\032\031\024\023\032\020\025\233\025\025\013\026\022 )0.5(\030\031\240\032\031\n\020\007\027\024\023\021\027\025\025\013\026\022 )0.6(\022\025\023\032\020)]TJ 0 Tw (-)Tj 0.177 Tw 0 -1.111 TD (\026\r\032\020\f\017\025\013\026\022 \025\031\021\031\031\240\032\020\016\ \031\021\020\025\022\t\026\022 \026\027\016\027\025\200\022\026\020\f\017\ \025\031\b\031 \033\032\031\022\024\200\031\255\030\027\025\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\255\027\f\r\030\031\007\025\031-\n\022\213\027\007\025\031\026 \023\032\ \020\n\023\027 \(\234\202\), )Tj 0.24 Tw 0 -1.111 TD (\026\027\030\f\027\025\025\031 \032\020\016\021\022\021\020\005\212\022\026\ \022\024\t \022\016)Tj /Span<>> BDC ( )Tj EMC (\255\022\032\031\021\031\235 \023\n\020\025\022. \217\024\025\031\021\025\ \020\t \007\020\024\023\017 \f\022\033\031\026 \f\031\n\020\f\022\016\r\027\ \023\024\t \021)Tj /Span<>> BDC ( )Tj EMC (\023\031\f\024\023\031\235 \n\022\213\n\027 )Tj 0.066 Tw T* (\(60\23175%\), \032\027\255\027)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\023\031\025\n\031\235 \n\022\213\n\027, \033\022\212\027\021\031\030\027\ \022)Tj /Span<>> BDC ( )Tj EMC (\255\027\f\r\030\n\027. \220\022\020\b\025\031\024\023\022\n\020 \031\024\ \025\031\021\013\021\020\027\023\024\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\204\025\030\031\024\n\031\033\022\007\027\024\n\031\026 )Tj 0.117 Tw T* (\022\024\024\f\027\030\031\021\020\025\022\022, \020)Tj /Span<>> BDC ( )Tj EMC (\023\031\007\025\r\005 \200\020\032\020\n\023\027\032\022\024\023\022\n\r\ \031\033\r\200\031\f\022 \033\031\016\021\031\f\t\027\023 \r\024\023\020\ \025\031\021\022\023\017 \204\025\030\031\024\031\025\031\b\032\020\203\022\ \t \(\230\210\205\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\230\210\205 )Tj -0.03 Tw T* (\f\022\033\031\026\013 \021\022\016\r\020\f\022\016\022\032\r\005\023\024\ \t \n\020\n \b\031\026\031\b\027\025\025\013\027 \b\022\033\027\032\204\200\ \031\b\027\025\025\013\027 \031\240\032\020\016\031\021\020\025\022\t, \022\ \024\200\031\030\t\212\022\027 \022\016)Tj /Span<>> BDC ( )Tj EMC (\033\031\030\024\f\022\016\022\024\023\031\b\031 \024\f\031\t \(3 )Tj 0.072 Tw T* [(\204\200\031\024\f\031\235\). )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC [(\024\f\r\007\020\027 \r\021\027\f\022\007\027\025\022\t )0.5(\032\020\016\026\027\032\031\021 )0.5(\022\f\022 \016\f\031\n\020\007\027\024\023\021\027\025\025\031\b\031 )0.5(\033\027\032\027\032\031\255\030\027\025\022\t \026\031\b\r\023 \033\032\ \022\026\027\025\t\023\017\024\t \026\027\023\031\030\013 )]TJ 0.176 Tw 0 -1.111 TD (\026\031\032\203\031\f\031\b\022\007\027\024\n\031\235 \021\027\032\022\203\ \022\n\020\006\022\022, \023\020\n\022\027 \n\020\n \212\022\033\006\027\ \021\020\t \240\022\031\033\024\022\t, \024\023\r\033\027\025\007\020\023\ \020\t \240\022\031\033\024\022\t \022\f\022 \023\031\025\n\031\022\b\031\ \f\017\025\020\t )Tj 0.222 Tw 0 -1.111 TD (\240\022\031\033\024\022\t \033\031\030 \n\031\025\023\032\031\f\027\026\ \230\210\205 \(\230\210\205-\002\004\). \210\030\020\f\027\025\022\027\ \033\031\n\020\016\020\025\031 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\022 \024\022\026\033\023\031\026\031\021 \(\240\031\ \f\017, \031\240\024\023\032\r\n\006\022\t, )Tj 0.147 Tw T* (\n\032\031\021\031\023\027\007\027\025\022\027\) \022\f\022 \033\032\022\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\016\026\027\032\020\200 \240\031\f\027\027 2 \024\026. \220\f\t\ \240\027\024\024\022\026\033\023\031\026\025\013\200 \031\240\032\020\016\ \031\021\020\025\022\235 \032\020\016\032\020\240\031\023\020\025\013 \033\ \032\031\023\031\n\031\f\013 )Tj 0.023 Tw T* (\025\020\240\f\005\030\027\025\022\t \024)Tj /Span<>> BDC ( )Tj EMC (\032\027\b\r\f\t\032\025\031\235 \204\025\030\031\024\n\031\033\022\007\027\ \024\n\031\235 \031\006\027\025\n\031\235 \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \032\020\016\026\027\ \032\031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\023\031\033\031\f\031\255\027\025\022\t.)Tj -0.002 Tc 0.019 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.5(\f\022\033\031\026\013 )0.5(\t\021\f\t\005\023\024\t )0.5(\031\030\025\022\026\022 )0.6(\022\016)]TJ /Span<>> BDC ( )Tj EMC 18.324 0 Td [(\025\020\022\240\031\f\027\027 )0.5(\007\020\024\023\031 )0.5(\021\024\023\032\027\007\020\005\212\022\200\024\t )0.6(\031\240\032\020\016\031\021\020\025\022\235 )0.5(\255\027\f\r\030\031\007\025\031-\n\022\213\027\007)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.009 Tw -18.324 -1.111 Td (\025\031\b\031 \023\032\020\n\023\020. \001\027\024\026\031\023\032\t \025\ \020)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\027 \033\020\023\031\b\025\031\026\031\025\022\007\ \025\013\200 \033\032\022\016\025\020\n\031\021, \033\031\016\021\031\f\t\ \005\212\022\200 \n\031\032\032\027\n\023\025\031 \033\031\024\023\020\021\ \022\023\017 \030\022\020\b)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw T* [(\025\031\016, )0.5(\033\032\022\026\027\025\027\025\022\027 \030\031\033\031\f\025\022\023\027\ \f\017\025\013\200 )0.5(\026\027\023\031\030\031\021 \031\240\024\f\027\030\031\021\020\025\022\t\ , )0.5(\023\020\n\022\200 )0.5(\n\020\n \204\025\030\031\024\031\025\031\b\032\020\203\022\t, \020)]TJ /Span<>> BDC ( )Tj EMC 36.413 0 Td [(\021 \025\027\n\031\023\031\032\013\200 )0.5(\024\f\r\007\020\t\200)-2( )]TJ -0.032 Tw -36.413 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\240\022\031\033\024\022\t \024)Tj /Span<>> BDC ( )Tj EMC (\006\027\f\017\005 \026\031\032\203\031\f\031\b\022\007\027\024\n\031\235\ \021\027\032\022\203\022\n\020\006\022\022, \030\031\f\255\025\013 \032\ \020\024\024\026\020\023\032\022\021\020\023\017\024\t \021)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\027 \024\023\020\025\030\020\032\023\025\031\b\ \031 \030\022\020\b)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.023 Tw T* (\025\031\024\023\022\007\027\024\n\031\b\031 \020\f\b\031\032\022\023\026\ \020, \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\020\025\022\022 \n\031\023\031\032\013\200 \021\013\ \024\023\032\020\022\021\020\027\023\024\t \030\020\f\017\025\027\235\213\ \020\t \023\020\n\023\022\n\020 \021\027\030\027\025\022\t \033\020\006\022\ \027\025\023\020.)Tj /T1_2 1 Tf 0.01 Tc 0.116 Tw 8 0 0 8 42.5596 111.3801 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.122 Tw 8.591 0 Td [( )0.5(\f\022\033\031\026\020, )0.5(\255\027\f\r\030\031\007\025\031-\n\022\213\027\007\025\013\235 )0.6(\023\032\020\n\023, )0.5(\204\025\030\031\024\n\031\033\022\007\027\024\n\020\t )0.5(\030\022\020\b\025\031\024\023\022\n\020, )0.5(\204\025\030\031\024\031\025\031\b\032\020\203\022\t, )0.6(\026\031\032\203\031\f\031\b\022\007\027\024\n\020\t )0.6(\021\027\032\022\203\022)]TJ 0 Tw (-)Tj -8.596 -1.2 Td (\n\020\006\022\t)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 325.1538 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 316.2265 Tm (\021\033\r\035\f\033)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5895 837.3533 Tm [(\200\n)43(\037\212\r\006\223\207\017\212\006\207)5( \n\207\212)21.1(\004\213\207\t\216)-21(\037\222\006\006)]TJ /T1_0 1 Tf 0 -1.605 TD [(PRA)15(CTIC)10(AL)5( REC)21(O)20(MMEND)20(A)30(TIONS)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 505.5644 56.0378 Tm (167)Tj ET q 0 g /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 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A)15.1(dipose-der)-37(i)-16(ved stem cells: )]TJ 0.012 Tc 0.433 Tw -1.796 -1.25 Td [(isol)-15.7(a)15.3(t)-31.7(ion, char)-32.7(a)-16.7(c)-15.7(ter)-36.7(iza)15.2(t)-31.7(ion, and dif)-55.7(fer)-23.7(ent)-31.7(ia)15.2(t)-31.7(ion po)17.3(tent)-31.7(ial. )]TJ /T1_1 1 Tf -0.012 Tw [(Cell)12( )]TJ 0 Tc 0 Tw T* [(T)56(ransplant.)]TJ /T1_0 1 Tf 0.023 Tw [( 2013;22\(4\):701\226709. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3727/096368912X655127)Tj 0 0 0 1 k /GS1 gs 0.121 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Johal)Tj /Span<>> BDC ( )Tj EMC [(K)-25(S, L)35(ees)]TJ /Span<>> BDC ( )Tj EMC [(VC, R)13(eid)]TJ /Span<>> BDC ( )Tj EMC [(AJ. A)15(dipose-der)-36.9(i)-16(ved stem cells: selec)-16(t)]TJ 0 Tw (-)Tj 0.012 Tc 0.446 Tw -1.796 -1.25 Td [(ing )0.5(for )0.5(tr)-33.1(ansl)-16(a)14.9(t)-32(ional )0.5(success. )]TJ /T1_1 1 Tf 14.035 0 Td [(R)20.9(eg)11.9(en )0.5(Med.)]TJ /T1_0 1 Tf [( )0.5(2015;10\(1\):79\22696.)12( )]TJ 0 Tc 0 Tw -14.035 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.2217/r)-16(me.14.72)]TJ 0 0 0 1 k /GS1 gs 0.122 Tw -1.847 -1.25 Td (73.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gent)-32(ile)]TJ /Span<>> BDC ( )Tj EMC [(P, Or)-30(l)-16(andi)]TJ /Span<>> BDC ( )Tj EMC [(A, S)-24(c)-23.9(iol)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(MG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Conc)-23.9(ise r)-23.9(ev)-16(iew: adipose-)]TJ 0.272 Tw -1.796 -1.25 Td [(der)-37(i)-15.9(ved str)-32(omal v)-15(ascul)-16(ar fr)-33(a)-17(c)-16(t)-32(ion cells and pl)-15.9(a)15(tele)-12(t-r)-37(ich pl)-16(as)26(ma: )]TJ 0.153 Tw T* [(basic and cl)-30.9(inical im)10(pl)-31(ica)15(t)-32(ions for t)-32(issue engineer)-36.9(ing t)-13(her)-32.9(apies in )]TJ 0.29 Tw T* [(r)-24(egener)-32.9(a)15(t)-32(i)-16(ve sur)-31.9(ger)-24(y. )]TJ /T1_1 1 Tf [(S)28(tem Cells T)56(ransl Med.)]TJ /T1_0 1 Tf ( 2012;1\(3\):230\226236. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.5966/sc)-16(tm.2011-0054)]TJ 0 0 0 1 k /GS1 gs 0.043 Tw -1.847 -1.25 Td (74.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhu)Tj /Span<>> BDC ( )Tj EMC [(M, )0.5(He)-11(yd)42(ar)-24(khan-Ha)-16.9(gv)-15(all)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(Hedr)-37(ick)]TJ /Span<>> BDC ( )Tj EMC [(M, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Manual isol)-15.9(a)15(t)-32(ion )]TJ 0.131 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(adipose-der)-36.9(i)-16(ved stem cells fr)-32(om human l)-31(ipoaspir)-32.9(a)15(tes. )]TJ /T1_1 1 Tf (J Vis Exp)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2013;\(79\):e50585. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3791/50585)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.364 Tw T* (75.)Tj /Span<>> BDC ( )Tj EMC 1.835 0 Td (\221\036\030\033\001\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\240.\230., \200\026\f\017\035\034\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\222., \200\026\032\036\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0 Tc 0.252 Tw -1.835 -1.25 Td (\214\036\004\036\027\017\036 \035\031\004\036\r\t\b \030\036\022\021\024\ \r\026\020\017\027\026\035\034\027\t\b \f\r\017\013\036\005. )Tj /T1_1 1 Tf (\215\031\024\n\031\021\024\n\022\235 \200\022\032\r\032)Tj 0 Tw (-)Tj 0.039 Tw T* (\b\022\007\027\024\n\022\235 \255\r\032\025\020\f.)Tj /T1_0 1 Tf [( 2019;\(2\):53\22656. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21518/1995-1477-2021-)Tj T* (18-1-82-90)Tj 0 0 0 1 k /GS1 gs 0.13 Tw [( / T)40(er)-24(yushkov)-14.9(a Zh.I., V)25(asil)35(yev)]TJ /Span<>> BDC ( )Tj EMC [(V.S., V)25(a)-24(zhenin)]TJ /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.009 Tc 0.354 Tw T* [(T)49.6(r)-24.4(ea)14.6(tment of)]TJ /Span<>> BDC ( )Tj EMC [(R)-10.4(adia)14.5(t)-32.4(ion R)12.6(ec)-16.4(t)16.6(ov)-15.4(a)-17.5(ginal F)-19.4(istul)-16.4(as. )]TJ /T1_1 1 Tf [(Moscow Surgical)9( )]TJ 0.004 Tc -0.004 Tw 29.055 23.75 Td [(Jour)-14.4(nal.)]TJ /T1_0 1 Tf 0.35 Tw [( 2019;\(2\):53\22656. \(in Russ.\). d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.21518/1995-1477-)Tj 0 Tc 0 Tw T* (2021-18-1-82-90)Tj 0 0 0 1 k /GS1 gs 0.002 Tw T* (76.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cheng)Tj /Span<>> BDC ( )Tj EMC (F, Huang)Tj /Span<>> BDC ( )Tj EMC [(Z, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(Z. Ef)-56(f)-28(ica)-17(cy and Safe)-12(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(Mesenchymal S)15(tem )]TJ 0.221 Tw -1.796 -1.25 Td [(Cells )0.5(in )0.5(T)50(r)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 9.344 0 Td [(Com)10(ple)-18(x )0.5(P)30(er)-37(ianal F)-19(istul)-15.9(as: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 12.425 0 Td [(Me)-12(t)15(a-Anal)35.1(y)-13(sis. )]TJ /T1_1 1 Tf 0.023 Tw -21.769 -1.25 Td [(S)28(tem Cells Int.)]TJ /T1_0 1 Tf [( 2020;2020:8816737. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2020/8816737)Tj 0 0 0 1 k /GS1 gs 0.018 Tc 0.662 Tw T* (77.)Tj /Span<>> BDC ( )Tj EMC 1.869 0 Td (\202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\222., \213\030\t\001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\224., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)18( )]TJ 0.01 Tc 0.375 Tw -1.869 -1.25 Td (\204\036\036\027\b\017\n\026\035\034\027\t\036 \f\021\r\024\035\024\r\t\ \036 \022\035\036\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\r\017\013\036\005 \023\036\030\017)Tj /Span<>> BDC (-)Tj EMC 0 Tc 0.296 Tw T* [(\026\027\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.266 0 Td [(\002\024\035\036\027\017 )0.5(\025\030\024\027\026 )0.5(\(\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 )0.6(\024\002\024\030 )]TJ 0.348 Tw -10.266 -1.25 Td (\035\017\021\036\030\026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_1 1 Tf 0 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf 0.348 Tw (. 2024;23\(3\):100\226)Tj 0.254 Tw T* [(111. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2024-23-3-100-111)Tj 0 0 0 1 k /GS1 gs 0.254 Tw ( / Anosov)Tj /Span<>> BDC ( )Tj EMC (I.S., )Tj 0.01 Tc 0.372 Tw T* [(Er)-23.9(y)-12.9(shov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(T.A., Khr)-24(yuk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(R.Y)35.1(u., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mesenchymal stem cells)10( )]TJ 0.004 Tc 0.35 Tw T* [(for per)-37.2(ianal f)-28.2(istul)-31.2(izing Cr)-32.2(ohn\241s disease \(sy)-13.2(stema)14.8(t)-32.2(ic r)-24.2(ev)-16.2(iew and)4( )]TJ 0 Tc 0 Tw T* [(me)-12.1(t)14.8(a-anal)34.9(y)-13.1(sis\). )]TJ /T1_1 1 Tf 6.786 0 Td [(K)17.9(olop)45.9(roktologia)]TJ /T1_0 1 Tf 0.35 Tw (. 2024;23\(3\):100\226111. \(in Russ.\). )Tj 0 Tw -6.786 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2024-23-3-100-111)Tj 0 0 0 1 k /GS1 gs -1.847 -1.25 Td (78.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mahmud)Tj /Span<>> BDC ( )Tj EMC [(N, P)40(ang)]TJ /Span<>> BDC ( )Tj EMC (W, Cobbs)Tj /Span<>> BDC ( )Tj EMC [(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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End)-16(oscopic appl)-30.9(ica)15(t)-32(ion )]TJ 0.221 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(human f)-28(ibr)-37(in seal)-16(ant in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-23.9(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer )]TJ 0.004 Tc -0.004 Tw T* [(s)0.5(yn)0.5(d)0.5(r)-31.6(o)0.5(m)0.5(e.)0.5( )]TJ /T1_2 1 Tf 4.802 0 Td [(E)0.5(nd)0.5(o)0.5(sc)0.5(o)0.5(p)12.4(y)]TJ /T1_1 1 Tf 0.349 Tw 4.112 0 Td [(.)0.5(19)0.5(9)0.5(2;)0.5(24)0.5(\()0.5(8\))0.5(:)0.5(73)0.5(6)0.5(\2267)0.5(37)0.5(.)0.5( d)-15.6(o)0.5(i)0.5(:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw [(1)0.5(0)0.5(.1)0.5(0)0.5(55)0.5(/s)0.5(-)0.5(2)0.5(00)0.5(7-)]TJ 0 Tc 0 Tw -8.914 -1.25 Td (1010574)Tj 0 0 0 1 k /GS1 gs 0.138 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)30(er)-32(gani)]TJ /Span<>> BDC ( )Tj EMC [(F)-10(J, S)-16(haiest)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (AA, Hajiani)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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End)-16(oscopic Submucosal )]TJ 0.014 Tc 0.52 Tw -1.796 -1.25 Td [(Dissec)-16.2(t)-32.2(ion Im)9.8(p)24.8(r)-32.1(oves Bl)29.8(o)-16.2(od)16.8(y S)14.8(t)16.8(o)-16.1(ol Asso)-16.2(c)-24.2(ia)14.8(ted wi)-24.1(t)-13.2(h P)9.9(ol)34.8(ypoid)14( )]TJ 0.01 Tc 0.385 Tw T* [(T)39.7(ype Mucosal P)34.7(r)-32.3(ol)-16.3(apse Syndr)-32.3(ome: A)]TJ /Span<>> BDC ( )Tj EMC [(Case Ser)-37.3(ies. )]TJ /T1_2 1 Tf [(Inter)-14.3(n Med.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2022;61\(21\):3211\2263215. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.2169/inter)-15(nalmedic)-23.9(ine.9182-21)]TJ 0 0 0 1 k /GS1 gs 0.008 Tc 0.349 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.827 0 Td [(Ai)-23.8(t)17.1(ol)-15.8(a)]TJ /Span<>> BDC ( )Tj EMC [(PT, Hil)56.2(tunen)]TJ /Span<>> BDC ( )Tj EMC [(KM, Ma)15.2(t)-31.9(ik)-16.8(ainen)]TJ /Span<>> BDC ( )Tj EMC [(MJ. F)10.2(unc)-15.8(t)-31.8(ional r)-23.8(esul)56.2(ts)8( )]TJ 0 Tc 0.289 Tw -1.827 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(oper)-33(a)15(t)-31.9(i)-16(ve tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15(al p)25(r)-31.9(ol)-16(apse over an)]TJ /Span<>> BDC ( )Tj EMC [(11-year per)-37(i)]TJ 0 Tw (-)Tj 0.01 Tc 0.37 Tw T* [(od: em)10.1(phasis on tr)-32.9(ansabd)-15.9(ominal app)25.1(r)-31.9(oa)-16.9(ch. )]TJ /T1_2 1 Tf [(Dis Colon R)21.1(ectum)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(1999;42\(5\):655\226660. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02234145)Tj 0 0 0 1 k /GS1 gs 0.124 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gaj)Tj /Span<>> BDC ( )Tj EMC [(F, L)-32(ai)]TJ /Span<>> BDC ( )Tj EMC [(Q, Gel)30(or)-15.9(mini)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-16.9(cy of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical tr)-23.9(ea)15(tments )]TJ 0.19 Tw -1.796 -1.25 Td [(for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-16.9(gement of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-24(t)15.1(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syndr)-32(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(ne)-12(t)-32(w)-14(or)-24(k )]TJ 0 Tw T* [(me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_2 1 Tf 0.155 Tw 6.22 0 Td (Colorectal Dis)Tj /T1_1 1 Tf [(. 2024;26\(8\):1515\226153. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -6.22 -1.25 Td (codi.17080)Tj 0 0 0 1 k /GS1 gs 0.088 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\200\024\005\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \221\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \207\017\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \003\026\032\017\r\035\036\027\017\036 )Tj 0.344 Tw -1.796 -1.25 Td (\f\024\035\017\021\026\030\027\t\b \016\r \023\030\016\n\024\005 \022\017\ \001\022\017 \023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 \035\036\004\036\027\017\016 )Tj -0.025 Tw T* (\030\036\022\021\026\035\034\027\024\020\024 \023\030\024\035\026\023\f\026\ . \221\036\017\f\t XII \222\255\036\007\026 \b\017\030\031\030\020\024\ \r \217\024\f\f\017\017, \217\024\f\021\024\r-)Tj 0.129 Tw T* (\027\026-\212\024\027\031. 7\2269)Tj /Span<>> BDC ( )Tj EMC [(\024\022\021\016\002\030\016. 2015 \020., \f. 199. / V)29(oinov)]TJ /Span<>> BDC ( )Tj EMC [(M.A., T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., )]TJ 0.11 Tw T* [(Bir)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC [(O.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Heal)-30.9(ing of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer)-9.9(s af)-28(ter sur)-32(gical )]TJ -0.025 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al p)25(r)-32(ol)-16(apse. A)-14(bstr)-32.9(a)-17(c)-16(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he XII Congr)-24(ess of)]TJ /Span<>> BDC ( )Tj EMC (Russian )Tj 0.023 Tw T* [(Sur)-32(geons, R)11(ost)17.1(ov-on-Don. O)-16(c)-16(t)17.1(ober 7\2269. 2015; \030. 199. \(in Russ.\).)]TJ 0.066 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ihna)15(t)]TJ /Span<>> BDC ( )Tj EMC [(P, Mar)-21.9(t)-32(inek)]TJ /Span<>> BDC ( )Tj EMC [(L, V)25(avr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(ovel combined app)25(r)-32(oa)-17(ch in )]TJ 0.153 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 1.736 0 Td [(mana)-17(gement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.795 0 Td [(non-heal)-31(ing )0.5(sol)-30.9(i)-24(t)15(ar)-24(y )0.5(r)-24(ec)-16(t)15.1(al )0.5(ul)16(cer )0.5(syndr)-32(ome)]TJ /Span<>> BDC ( )Tj EMC 18.106 0 Td (\227 )Tj 0.162 Tw -26.638 -1.25 Td [(l)-16(ap)32(ar)-32(oscopic r)-23.9(esec)-16(t)-32(ion r)-24(ec)-16(t)17(ope)-17.9(xy and tr)-32.9(ansanal end)-16(oscopic micr)-32(o)]TJ 0 Tw (-)Tj T* [(sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf 0.228 Tw 3.762 0 Td [(Wideochir Inne T)54(ech Maloin)12.1(w)13(azyjne)]TJ /T1_1 1 Tf (. 2015;10\(2\):295\226298. )Tj 0 Tw -3.762 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.5114/wi)-16(i)-23.9(tm.2015.52060)]TJ 0 0 0 1 k /GS1 gs 0.173 Tw -1.847 -1.25 Td (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)17(ol)56(tz)]TJ /Span<>> BDC ( )Tj EMC [(JF, de Isl)-16(a)]TJ /Span<>> BDC ( )Tj EMC [(N, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(YP, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(tem Cells and R)13(egener)-33(a)15(t)-32(i)-16(ve )]TJ 0.31 Tw -1.796 -1.25 Td [(Medic)-24(ine: M)16(y)-15.9(t)-13(h or R)13(eal)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he 21t)-13(h Centur)-24(y. )]TJ /T1_2 1 Tf [(S)28(tem Cells Int)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2015;2015:734731. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2015/734731)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.371 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td (\204\026\035\026\005\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \222\031\b\017\b)Tj /Span<>> BDC ( )Tj EMC [(\206.\221. \222\024\r\030\036\n\036\027\027\t\036)10( )]TJ 0 Tc 0.189 Tw -1.836 -1.25 Td (\023\030\036\007\f\021\026\r\035\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\017 \f\021\r\024\035\024\r\024\005 \022\035\ \036\021\022\017. )Tj /T1_2 1 Tf (\003\032\200\022\021 \033\020\023\031\f\031\b\022\022.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.228 Tw T* [(2002;64\(4\):7\22611. / Mal)-15.9(a)15(y)-16(tsev)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Bo)-15.9(gd)42(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (I.M., Sukhikh)Tj /Span<>> BDC ( )Tj EMC (G.T. )Tj 0.01 Tc 0.39 Tw T* [(M)-24.4(oder)-15.4(n )0.6(Concepts )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 9.519 0 Td [(S)14.5(tem )0.5(Cell )0.5(Biol)29.5(o)-16.4(g)15.5(y. )]TJ /T1_2 1 Tf 0.011 Tc 0.389 Tw 8.799 0 Td [(A)0.6(r)0.5(c)0.6(h)0.6(i)0.5(v)13.5(e)0.6( )0.6(o)0.5(f)]TJ /Span<>> BDC 4.362 0 Td ( )Tj EMC 0.632 0 Td [(P)18.6(a)0.5(t)0.6(h)0.5(o)0.6(l)0.6(o)0.5(g)0.6(y)0.5(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 4.324 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (2002;64\(4\):7\22611. \(in Russ.\).)Tj 0.154 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\024\035\021\026\r\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \217\036\r\017\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \202\035\036\022\f\026\027\007\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.017 Tw -1.796 -1.25 Td (\203\036\005\030\026\035\034\027\t\036 \f\021\r\024\035\024\r\t\036 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\036\027\017\021\024\030\027\t\036 \022\035\036\021\022\017\ \220\n\002\030\017\024\027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024)Tj 0 Tw (-)Tj 0.009 Tc 0.353 Tw T* (\007\024\r \004\036\035\024\r\036\022\026)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\f\027\024\r\026 \027\024\r\t\b \002\017\024\n\036\007\017\006\017\ \027\f\022\017\b \021\036\b\027\024\035\024\020\017\005.)9( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\217\025\023\031\b\027\025\027\016)Tj /T1_1 1 Tf 0.123 Tw [(. 2003;34\(3\):211\226215. / P)10(ol)56(t)15(av)-24(tsev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.A., R)13(ev)-16(ishin)]TJ /Span<>> BDC ( )Tj EMC (A.V., )Tj 0.038 Tw T* [(Alek)-9.9(sandr)-32(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Neur)-33(al stem and p)25(r)-32(o)-16(geni)-24(t)17(or cells of)]TJ /Span<>> BDC ( )Tj EMC (human )Tj 0.124 Tw T* [(embr)-24(yos )0.5(and fe)-12(tuses)]TJ /Span<>> BDC ( )Tj EMC [(\227 t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 11.886 0 Td (basis of)Tj /Span<>> BDC ( )Tj EMC 3.548 0 Td [(new biomedical )0.5(technol)30(o)-15.9(gies. )]TJ /T1_2 1 Tf 0 Tw -15.434 -1.25 Td [(Ontog)12(enesis)]TJ /T1_1 1 Tf 0.023 Tw (. 2003;34\(3\):211\226215. \(in Russ.\).)Tj 0.016 Tc 0.571 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.859 0 Td (\222\031\b\017\b)Tj /Span<>> BDC ( )Tj EMC (\206.\221., \204\026\035\026\005\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)16.1( )]TJ 0 Tc 0.158 Tw -1.859 -1.25 Td (\204\036\036\027\b\017\n\026\035\034\027\t\036 \f\021\r\024\035\024\r\t\ \036 \022\035\036\021\022\017. )Tj /T1_2 1 Tf 0 Tw (\221\230\221\215)Tj /T1_1 1 Tf 0.158 Tw (. 2002;133\(2\):124\226131. )Tj 0.105 Tw T* (/ Sukhikh)Tj /Span<>> BDC ( )Tj EMC [(G.T., Mal)-16(a)15(y)-16(tsev)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Bo)-16(gd)42(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(I.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Mesenchymal )Tj 0.023 Tw T* (stem cells. )Tj /T1_2 1 Tf 0 Tw (BEBM)Tj /T1_1 1 Tf 0.023 Tw (. 2002;133\(2\):124\226131. \(in Russ.\).)Tj 0.238 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(imonson)]TJ /Span<>> BDC ( )Tj EMC 4.376 0 Td [(OE, )0.6(Domo)-16(ga)15(tsk)-17(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC 7.945 0 Td [(A, )0.6(V)29(ol)16(chkov)]TJ /Span<>> BDC ( )Tj EMC 5.241 0 Td [(P, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.468 0 Td [(al. )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.359 0 Td [(safe)-12(t)-10(y )]TJ 0.246 Tw -25.185 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(human pl)35(ur)-36.9(ipo)17(tent stem cells in cl)-31(inical tr)-24(ea)15(tment. )]TJ /T1_2 1 Tf (Ann Med.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2015;47\(5\):370\226380. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3109/07853890.2015.1051579)Tj 0 0 0 1 k /GS1 gs 0.232 Tw 29.055 81.25 Td (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\217\036\023\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\222, \217\032\026\027\017\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \231\026\n\036\027\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202. \233\n\002\030\017\024\027\026\035\034\027\t\036 )Tj 0.013 Tc 0.471 Tw -1.796 -1.25 Td (\f\021\r\024\035\024\r\t\036 \022\035\036\021\022\017: \235\031\027\007\026\ \n\036\027\021\026\035\034\027\026\016 \002\017\024\035\024\020\017\016 \ \017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\007\017\006\017\027\026.)13( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\206\027\215\027\027\n\024)Tj /T1_1 1 Tf -0.039 Tw [(. 2002; 176 c./ R)13(epin)]TJ /Span<>> BDC ( )Tj EMC [(V.S., Rzhaninov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(A.A., S)-16(hamenkov)]TJ /Span<>> BDC ( )Tj EMC (D.A. )Tj 0.077 Tw T* [(Embr)-23.9(yonic S)15(tem Cells: )0.5(F)10(und)42(ament)15(al Biol)30(o)-16(g)16(y )0.5(and Medic)-24(ine. )]TJ /T1_2 1 Tf 0 Tw [(R)21(eMeT)54.1(e)-15(x.)]TJ /T1_1 1 Tf ( )Tj 0.023 Tw T* (2002; 176 p. \(in Russ.\).)Tj -0.011 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ohlstein)Tj /Span<>> BDC ( )Tj EMC [(B, K)-16(ai)]TJ /Span<>> BDC ( )Tj EMC [(T, Deco)17(t)-30(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(stem cell niche: t)-13(heme and )]TJ 0 Tw -1.796 -1.25 Td [(v)-15(ar)-36.9(ia)15(t)-32(ions. )]TJ /T1_2 1 Tf 0.067 Tw 4.668 0 Td [(Cur)-16(r Opin Cell Biol.)]TJ /T1_1 1 Tf [( 2004;16\(6\):693\226699. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -4.668 -1.25 Td (ceb.2004.09.003)Tj 0 0 0 1 k /GS1 gs 0.247 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\030\017\007\036\027\001\021\036\005\027)Tj /Span<>> BDC ( )Tj EMC (\202.\242., \214\026\035\t\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\025.\222. \230\027\007\031\022\006\017\016 \022\024\f\021\027\024\005 \021\ \022\026\027\017 )Tj 0.344 Tw -1.796 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\036\024\020\036\027\027\t\036 \022\035\036\021\022\017-\023\030\ \036\007\001\036\f\021\r\036\027\027\017\022\017. \204., \204\036\007\017\ \006\017\027\026, 1973./ )Tj 0.004 Tw T* [(F)10(r)-37(idenshtein)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)50.1(a., L)-32(al)35.1(yk)-16(ina)]TJ /Span<>> BDC ( )Tj EMC [(K.S. Induc)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(bone t)-32(issue and osteo)]TJ 0 Tw (-)Tj 0.023 Tw T* [(genic p)25(r)-23.9(ecur)-10(sor cells. M)-24(osco)-14(w, Medic)-23.9(ine. 1973. \(in Russ.\).)]TJ 0.033 Tw T* (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Majumd)42(ar)]TJ /Span<>> BDC ( )Tj EMC [(MK, T)47(hiede)]TJ /Span<>> BDC ( )Tj EMC [(MA. M)-24(osca)]TJ /Span<>> BDC ( )Tj EMC [(J.D. Pheno)17(t)-10(ypic and func)-16(t)-32(ional )]TJ 0.142 Tw -1.796 -1.25 Td [(com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(cul)56.1(tur)-24(es of)]TJ /Span<>> BDC ( )Tj EMC [(mar)-24(r)-32(o)-14(w-der)-36.9(i)-16(ved mesenchymal stem cells )]TJ 0.088 Tw T* [(and str)-31.9(omal cells. )]TJ /T1_2 1 Tf [(J Cell Ph)12(ysiol.)]TJ /T1_1 1 Tf [( 1998;176\(1\):57\22666. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/)Tj T* [(\(SICI\)1097-4652\(199807\)176:1<57::AID-JCP7>3.0.C)13.2(O;2-7)]TJ 0 0 0 1 k /GS1 gs 0.312 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)50(r)-24(emain)]TJ /Span<>> BDC ( )Tj EMC [(N, K)25.1(or)-24(kko)]TJ /Span<>> BDC ( )Tj EMC [(J, Ibber)-9.9(son)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(oSA)16(GE anal)35(y)-13(sis )]TJ 0.179 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(2353 e)-18(xp)25(r)-24(essed genes in a)]TJ /Span<>> BDC ( )Tj EMC [(single cell-der)-37(i)-15.9(ved col)30(ony of)]TJ /Span<>> BDC ( )Tj EMC (undif)Tj 0 Tw (-)Tj -0.007 Tw T* [(fer)-23.9(ent)-32(ia)15(t)-32(ia)15(ted )0.5(human )0.5(mesenchymal )0.5(stem )0.5(cells )0.5(r)-23.9(eveals )0.5(mRN)13(A)35(S )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (mul)Tj 0 Tw (-)Tj 0.141 Tw T* [(t)-32(iple cell l)-31(inea)-17(ges. )]TJ /T1_2 1 Tf [(S)28(tem Cells)]TJ /T1_1 1 Tf [(. 2001;19\(5\):408\226418. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1634/)Tj T* (stemcells.19-5-408)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.365 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.835 0 Td [(Al)-30.7(ison)]TJ /Span<>> BDC ( )Tj EMC [(MR, P)10.2(oulsom)]TJ /Span<>> BDC ( )Tj EMC [(R, Ot)-29.7(t)17.2(o)]TJ /Span<>> BDC ( )Tj EMC [(WR, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Sur)-32.2(gical tr)-24.2(ea)14.8(tment)6.1( )]TJ 0 Tc 0.051 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(f)16(amil)-30.9(ial adenoma)15.1(t)16.9(ous )0.5(pol)35(yposis )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30.1(on using cell)35.1(ul)-16(ar r)-24(econ)]TJ 0 Tw (-)Tj 0.105 Tw T* [(str)-21.9(uc)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-15.9(t)15(al mucosa. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46.1(roktologia)]TJ /T1_1 1 Tf 0.105 Tw (. 2017;\(3S\):84a\22685. )Tj 0.023 Tw T* (\(in Russ.\).)Tj 0.131 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hung)Tj /Span<>> BDC ( )Tj EMC (SC, Chen)Tj /Span<>> BDC ( )Tj EMC (NJ, Hsieh)Tj /Span<>> BDC ( )Tj EMC [(SL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Isol)-16(a)15.1(t)-32(ion and char)-32.9(a)-17(c)-16(ter)-37(iza)]TJ 0 Tw (-)Tj 0.071 Tw -1.796 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(size-sieved stem cells fr)-32(om human bone mar)-24(r)-32(o)-14(w. )]TJ /T1_2 1 Tf [(S)28(tem Cells.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2002;20\(3\):249\22658. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1634/stemcells.20-3-249)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.446 Tw T* (63.)Tj /Span<>> BDC ( )Tj EMC 1.844 0 Td (\215\036\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \230\r\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\233.\203., \215\036\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC [(\224.\202. \222\021\r\024\035\024\r\t\036)12( )]TJ 0.005 Tc 0.35 Tw -1.844 -1.25 Td (\022\035\036\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\030\024\r\024\005 \021\022\026\027\017. )Tj /T1_2 1 Tf -0.005 Tw (\221io\023\027\200\025\031\f\031\bi\t)Tj /T1_1 1 Tf 0.35 Tw [(. 2008;1\(4\):39\22647. /)5( )]TJ 0 Tc 0.064 Tw T* [(P)30(e)-12(tr)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., Iv)-15(anov)]TJ /Span<>> BDC ( )Tj EMC [(E.N., P)30(e)-12(tr)-23.9(enko Y)35(u.A. 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M)-24(or)-24(eir)-32.9(a V)-15(icente)]TJ /Span<>> BDC ( )Tj EMC [(V, R)13(ed)-16(ond)-16(o V)30(er)-31.9(ge)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.144 Tw -1.296 -1.25 Td [(Enfer)-15.9(med)42(ad de )0.5(l)-16(a )0.5(tr)-24(es )0.5(ment)-31.9(ir)-33(as: )0.5(s\355ndr)-32(ome )0.5(de )0.5(l)-16(a )0.5(\372l)16(cer)-33(a )0.5(r)-24(ec)-16(t)15(al )0.5(sol)-30.9(i)]TJ 0 Tw (-)Tj 0 -1.25 TD [(t)15(ar)-37(ia. )]TJ /T1_1 1 Tf 0.074 Tw 2.497 0 Td [(R)21(ev Esp Enfer)-14(m Dig. )]TJ /T1_0 1 Tf [(2007;99\(11\):663\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4321/s1130-)Tj -2.497 -1.25 Td (01082007001100009)Tj 0 0 0 1 k /GS1 gs 0.026 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(or)-32(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M, Dar)-32(v)-15.9(ishi)]TJ /Span<>> BDC ( )Tj EMC [(M. S)-16(ol)-31(i)-24(t)15(ar)-23.9(y r)-24(ec)-16(t)15.1(al ul)16(cer syndr)-32(ome: A)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stem)]TJ 0 Tw (-)Tj -0.016 Tw -1.296 -1.25 Td [(a)15(t)-32(ic r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf (Medicine \(Baltimore\).)Tj /T1_0 1 Tf [( 2018;97\(18\):e0565. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (MD.0000000000010565)Tj 0 0 0 1 k /GS1 gs 0.255 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Sadeghi)Tj /Span<>> BDC ( )Tj EMC [(A, Bigl)-16(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(M, F)10(or)-32(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-31(i)-23.9(t)15(ar)-24(y R)13(ec)-16(t)15(al Ul)16(cer )]TJ -0.053 Tw -1.296 -1.25 Td [(Syndr)-32(ome: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC [(Nar)-24(r)-32.9(a)15(t)-32(i)-16(ve )0.5(R)13(ev)-16(iew)]TJ /T1_1 1 Tf [(. Middle )0.5(East )0.5(J Dig )0.5(Dis.)]TJ /T1_0 1 Tf ( 2019;11\(3\):129\226)Tj 0.023 Tw T* [(134. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.15171/mejdd.2019.138)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ok)-17(a)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(K, Aok)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, Ued)42(a)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnost)-32(ic techniques for r)-24(ec)-16(t)15(al )]TJ -0.005 Tw -1.296 -1.25 Td [(mucosal p)25(r)-32(ol)-16(apse syndr)-32(ome. )]TJ /T1_1 1 Tf [(Nihon Syouk)11(aki N)18(aishikyou Gakk)11(ai Zasshi )]TJ 0.023 Tw T* (\(Gastroenterol Endosc\).)Tj /T1_0 1 Tf ( 2014;56:494\226503.)Tj 0.225 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(an)]TJ /Span<>> BDC ( )Tj EMC (Q, Zhou)Tj /Span<>> BDC ( )Tj EMC (J, Zhao)Tj /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(r)-33(ar)-23.9(e case r)-24(epor)-21.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(muc)-24(inous )]TJ 0.125 Tw -1.296 -1.25 Td [(adeno)-16(car)-32(c)-24(inoma e)-18(x)-10.9(a)-17(cer)-24(ba)15(ted b)12(y l)30(ong-st)15(anding sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer )]TJ 0 Tw T* [(syndr)-32(ome. )]TJ /T1_1 1 Tf 0.023 Tw 4.44 0 Td [(AME Case R)21(ep.)]TJ /T1_0 1 Tf [( 2024;24\(8\):63. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.21037/a)-17(cr-23-207)]TJ 0 0 0 1 k /GS1 gs 0.098 Tw -4.44 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-14(bid)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(cl)-31(inical, end)-16(oscopic and hist)17(ol)30(o)-16(gical spec)-16(tr)-22(um )]TJ 0.232 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he sol)-31(i)-24(t)15(ar)-23.9(y r)-24(ec)-15.9(t)15(al ul)16(cer syndr)-31.9(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(single-center e)-18(xper)-37(ience )]TJ 0.213 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (116 cases. )Tj /T1_1 1 Tf (BMC Gastroenterol.)Tj /T1_0 1 Tf [( 2012;12:72. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1471-)Tj T* (230X-12-72)Tj 0 0 0 1 k /GS1 gs 0.127 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dehghani)Tj /Span<>> BDC ( )Tj EMC [(SM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-31(i)-24(t)15.1(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syndr)-32(ome: Is i)-24(t r)-23.9(eall)35(y )]TJ 0.224 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(r)-33(ar)-23.9(e condi)-24(t)-32(ion in )0.5(childr)-24(en? )]TJ /T1_1 1 Tf [(W)29(orld )0.5(Jour)-14(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(Clinical )0.5(P)15(ediatr)-36.9(ics.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2016;5\(3\):343\226348. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5409/wjcp.v5.i3.343)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.349 Tw T* [(1)0.5(1)0.5(.)]TJ /Span<>> BDC 1.303 0 Td ( )Tj EMC 0.502 0 Td [(S)0.5(a)0.5(f)16.6(a)0.5( O)0.5(u)0.5(r)-36.4(i)0.5(d)42.5(a)0.5(,)0.6( M)0.5(a)0.6(r)-36.5(i)0.5(e)0.6(m)0.5( E)0.5(l)0.5(l)0.6(e)0.5(u)0.5(c)0.6(h)0.5(,)0.5( I)0.5(n)0.5(e)0.6(s)0.5( L)-31.4(a)0.5(m)0.5(l)30.6(o)0.5(u)0.5(m)0.6(,)0.5( e)-11.4(t)]TJ /Span<>> BDC 20.574 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( S)-15.5(o)0.6(l)56.5(t)15.5(a)0.6(i)0.5(r)-23.5(y)3( )]TJ 0 Tc 0.283 Tw -22.38 -1.25 Td [(R)13(ec)-16(t)15(al Ul)16(cer Syndr)-32(ome: An)]TJ /Span<>> BDC ( )Tj EMC [(E)35(x)-13(cept)-31.9(ional Ent)-32(i)-24(t)-10(y in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Elder)-30(l)35(y. )]TJ /T1_1 1 Tf 0 Tw (J. )Tj 0.022 Tc 0.809 Tw T* [(Gastroenterology P)17.6(ancreatology and Hepatobilar)-43.4(y Disorder.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;5\(4\):01\22602. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.31579/2641-5194/033)Tj 0 0 0 1 k /GS1 gs -0.017 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(KR, R)-24(iddell)]TJ /Span<>> BDC ( )Tj EMC 7.253 0 Td [(RH. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-24(t)15(ar)-23.9(y ul)16(cer syndr)-32(ome of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-16(tum. )]TJ /T1_1 1 Tf 0.023 Tw -9.049 -1.25 Td (Clin Gastroenterol)Tj /T1_0 1 Tf (. 1975;4\(3\):505\226530.)Tj 0.048 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Du Boul)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(CE, F)20(air)-23.9(br)-32(o)17(t)-13(her)]TJ /Span<>> BDC ( )Tj EMC [(J, Isaa)-17(cson)]TJ /Span<>> BDC ( )Tj EMC [(PG. Mucosal p)25(r)-32(ol)-16(apse syn)]TJ 0 Tw (-)Tj 0.029 Tw -1.796 -1.25 Td [(dr)-32(ome)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(unif)-34(ying concept for sol)-31(i)-24(t)15(ar)-23.9(y ul)16.1(cer syndr)-32(ome and r)-24(el)-15.9(a)15(ted )]TJ 0 Tw T* [(disor)-24(der)-9.9(s. )]TJ /T1_1 1 Tf 0.333 Tw 4.549 0 Td [(J )0.5(Clin )0.5(P)18(athol)]TJ /T1_0 1 Tf [(. )0.5(1983;36\(11\):1264\2261268. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 19.349 0 Td (10.1136/)Tj -23.899 -1.25 Td (jcp.36.11.1264)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.383 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.837 0 Td [(P)39.7(ar)-24.3(k)-10.2(s)]TJ /Span<>> BDC ( )Tj EMC [(A)15.7(G, P)9.8(or)-22.2(ter)]TJ /Span<>> BDC ( )Tj EMC [(NH, Har)-24.3(dcastle)]TJ /Span<>> BDC ( )Tj EMC [(J. T)46.7(he)]TJ /Span<>> BDC ( )Tj EMC [(syndr)-32.3(ome of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.2(he)10( )]TJ 0.012 Tc 0.456 Tw -1.837 -1.25 Td [(descending per)-37.3(ineum. )]TJ /T1_1 1 Tf (Proc R Soc Med)Tj /T1_0 1 Tf [(. 1966;59\(6\):477\226482.)12( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/003591576605900601)Tj 0 0 0 1 k /GS1 gs -0.034 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ni)-16(v)]TJ /Span<>> BDC ( )Tj EMC [(Y, S)-16(hemesh)]TJ /Span<>> BDC ( )Tj EMC [(E, Ba)15(t)]TJ /Span<>> BDC ( )Tj EMC [(L. S)-16(ol)-31(i)-24(t)15.1(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer syndr)-31.9(ome. )]TJ /T1_1 1 Tf 0 Tw (Harefuah.)Tj /T1_0 1 Tf ( )Tj -1.796 -1.25 Td (1981;100\(12\):581\226583.)Tj 0.278 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(and)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(RK, A)30(tmakur)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(SP, Mehr)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(NK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Is sol)-31(i)-24(t)15(ar)-24(y r)-24(ec)-15.9(t)15(al )]TJ 0.21 Tw -1.796 -1.25 Td [(ul)16(cer a)]TJ /Span<>> BDC ( )Tj EMC [(manifest)15(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stemic disease? )]TJ /T1_1 1 Tf (J Clin Gastroenterol. )Tj /T1_0 1 Tf 0.023 Tw T* [(1990;12\(3\):286\226290. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00004836-199006000-00010)Tj 0 0 0 1 k /GS1 gs 0.086 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Contr)-33(a)-17(c)-15.9(t)17(or)]TJ /Span<>> BDC ( )Tj EMC 4.587 0 Td [(T)25(Q, )0.5(Contr)-33(a)-17(c)-16(t)17(or)]TJ /Span<>> BDC ( )Tj EMC 6.083 0 Td [(QQ. )0.5(T)50(r)-33(auma)15(t)-32(ic )0.5(sol)-31(i)-24(t)15.1(ar)-24(y )0.5(r)-24(ec)-16(t)15(al )0.5(ul)16(cer )0.5(in )]TJ -0.002 Tw -12.466 -1.25 Td [(Saudi Ar)-32.9(abia. A)]TJ /Span<>> BDC ( )Tj EMC [(dist)-32(inc)-16(t ent)-32(i)-24(t)-10(y? )]TJ /T1_1 1 Tf (J Clin Gastroenterol)Tj /T1_0 1 Tf ( 1995;21\(4\):298\226)Tj 0.023 Tw T* [(300. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00004836-199512000-00010)Tj 0 0 0 1 k /GS1 gs 0.224 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(r)-24(eimanis)]TJ /Span<>> BDC ( )Tj EMC [(MG, W)12(ald)]TJ /Span<>> BDC ( )Tj EMC [(A, Car)-21.9(uana)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ev)-15(a)-17(cua)15(t)-32(ion p)25(r)-32(o)-16(c)-15.9(t)17(o)-16(g)]TJ 0 Tw (-)Tj 0.342 Tw -1.796 -1.25 Td [(r)-33(aphy in nor)-16(mal vol)35.1(unteer)-10(s. )]TJ /T1_1 1 Tf [(In)11(v)13(est R)20(adiol.)]TJ /T1_0 1 Tf ( 1991;26\(6\):581\226585. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/00004424-199106000-00015)Tj 0 0 0 1 k /GS1 gs 0.044 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (He)Tj /Span<>> BDC ( )Tj EMC [(CC, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (SP, Zhou)Tj /Span<>> BDC ( )Tj EMC [(PR, e)-12(t al. Inher)-36.9(i)-24(ted CHEK2 p.H371Y mut)15(a)]TJ 0 Tw (-)Tj 0.335 Tw -1.796 -1.25 Td [(t)-32(ion in sol)-31(i)-24(t)15.1(ar)-24(y r)-24(ec)-15.9(t)15(al ul)16(cer syndr)-32(ome among f)16(amil)-31(ial p)32(a)15(t)-32(ients: )]TJ 0.01 Tc 0.364 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(case r)-23.8(epor)-21.8(t. )]TJ /T1_1 1 Tf [(W)29.3(orld J Gastroenterol.)]TJ /T1_0 1 Tf [( 2023;29\(31\):4809\2264814.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3748/wjg.v29.i31.4809)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.454 Tw -1.847 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.845 0 Td (\207\024\002\030\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\207. \222\017\027\007\030\024\n \f\024\035\017\021\026\030\027\024\ \005 \016\r\t \023\030\016\n\024\005 \022\017\001\022\017.)12( )]TJ /T1_1 1 Tf 0 Tc 0 Tw -1.845 -1.25 Td (\230\025\030\031\024\n\031\033\022\t)Tj /T1_0 1 Tf 0.125 Tw [(. 2013;2:18\22622./ Bobr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.B. S)-16(ol)-31(i)-23.9(t)15(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syn)]TJ 0 Tw (-)Tj T* [(dr)-32(ome. )]TJ /T1_1 1 Tf 3.087 0 Td [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.023 Tw (. 2013;2:18\22622. \(in Russ.\).)Tj 0.018 Tw -3.087 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Huang)Tj /Span<>> BDC ( )Tj EMC [(Y, L)-31.9(in)]TJ /Span<>> BDC ( )Tj EMC (X, Han)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic fea)15(tur)-24(es of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al muco)]TJ 0 Tw (-)Tj -0.004 Tw -1.796 -1.25 Td [(sal p)25(r)-32(ol)-15.9(apse syndr)-32(ome \(RMPS\): Dif)-56(fer)-23.9(ent)-32(ia)15(t)-32(ion fr)-31.9(om mal)-31(ignant r)-24(ec)-16(t)15(al )]TJ 0 Tw T* (tumor)Tj /T1_1 1 Tf 0.016 Tw (. Endosc Int Open.)Tj /T1_0 1 Tf [( 2024;12\(11\):E1303\226E1308. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-)Tj T* (2390-2946)Tj 0 0 0 1 k /GS1 gs 0.293 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)20(ong)]TJ /Span<>> BDC ( )Tj EMC [(YP, K)-16(abincona)]TJ /Span<>> BDC ( )Tj EMC (C, Jabar)Tj /Span<>> BDC ( )Tj EMC [(MF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)15(al P)10(ol)35(yposis in )]TJ 0.243 Tw -1.796 -1.25 Td [(Mucosal P)35(r)-32(ol)-15.9(apse Syndr)-32(ome. )]TJ /T1_1 1 Tf (Diagnostics \(Basel\).)Tj /T1_0 1 Tf ( 2022;12\(4\):966. )Tj 0 Tw 0 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3390/dia)-17(gnost)-31.9(ics12040966)]TJ 0 0 0 1 k /GS1 gs 0.178 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Es)26(maeil)35(y)]TJ /Span<>> BDC ( )Tj EMC 3.855 0 Td [(H)49(A. )0.5(Hist)17(op)32(a)15(t)-13(hol)30.1(o)-16(gical )0.5(misdia)-17(gnosis )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y )0.5(r)-24(ec)-16(t)15(al )]TJ 0.016 Tw -5.651 -1.25 Td [(ul)16(cer syndr)-32(ome. )]TJ /T1_1 1 Tf [(R)21(esearch jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (biological sciences.)Tj /T1_0 1 Tf ( 2008;3:1171.)Tj -0.055 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-33(ak)-17(ash)]TJ /Span<>> BDC ( )Tj EMC [(N, V)-16(y)22(as)]TJ /Span<>> BDC ( )Tj EMC [(SJ, M)-23.9(ohammed)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Infl)-16(amma)15.1(t)17(or)-24(y Cl)30(oa)-17(co)-16(genic )]TJ 0.129 Tw -1.796 -1.25 Td [(P)10(ol)35(yp: A)]TJ /Span<>> BDC ( )Tj EMC [(R)-10(ar)-24(e Benign Col)30(or)-23.9(ec)-16(t)15(al P)10(ol)35(yp. )]TJ /T1_1 1 Tf 0 Tw (Cureus.)Tj /T1_0 1 Tf 0.129 Tw ( 2022;14\(2\):e22014. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.7759/cur)-23.9(eus.22014)]TJ 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw 27.208 81.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.805 0 Td [(L)34.6(ev)-16.4(ine)]TJ /Span<>> BDC ( )Tj EMC [(DS. \236S)-16.4(ol)-31.3(i)-24.4(t)14.7(ar)-24.4(y\237 r)-24.4(ec)-16.4(t)14.7(al ul)15.7(cer syndr)-32.4(ome. Ar)-24.4(e \236sol)-31.4(i)-24.3(t)14.6(ar)-24.4(y\237)2.1( )]TJ 0.007 Tc -1.805 -1.25 Td [(r)-24.3(ec)-16.4(t)14.7(al ul)15.7(cer syndr)-32.3(ome and \236l)29.6(o)-16.3(cal)-31.3(ized\237 col)-31.3(i)-24.4(t)-32.3(is cy)-13.3(st)-32.4(ica p)24.7(r)-32.3(ofund)41.7(a)7( )]TJ 0 Tc 0.176 Tw T* [(anal)30(o)-16(gous syndr)-31.9(omes caused b)12(y r)-24(ec)-15.9(t)15(al p)25(r)-32(ol)-16(apse? )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology.)Tj /T1_0 1 Tf ( )Tj T* (1987;92\(1\):243\226253.)Tj 0.153 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)20(ong)]TJ /Span<>> BDC ( )Tj EMC [(W, L)-32(ai)]TJ /Span<>> BDC ( )Tj EMC [(K, S)-16(hek)]TJ /Span<>> BDC ( )Tj EMC [(T)-48(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Self-infl)-30.9(ic)-16(ted r)-24(ec)-16(t)15(al ul)16(cer wi)-23.9(t)-13(h )]TJ 0.111 Tw -1.796 -1.25 Td [(e)-18(xuber)-32.9(ant gr)-33(anul)-16(a)15(t)-32(ion t)-13(ha)15.1(t mimics car)-32(c)-24(inoma. )]TJ /T1_1 1 Tf (Gastrointest Endosc.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2002;55\(7\):951\226952. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1067/mge.2002.124556)Tj 0 0 0 1 k /GS1 gs 0.165 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\036\030\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC [(\202.\213., )0.5(\221\030\031\002\026\004\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 10.99 0 Td (\224.\214., \200\t\001\036\020\024\030\024\007\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \017)Tj /Span<>> BDC ( )Tj EMC 12.302 0 Td (\f\024\026\r\021. )Tj 0.009 Tc 0.351 Tw -25.088 -1.25 Td (\211\035\034\021\030\026\r\031\022\024\r\026\016 \007\017\026\020\027\024\ \f\021\017\022\026 \f\017\027\007\030\024\n\026 \f\024\035\017\021\026\030\ \027\024\005 \016\r\t \023\030\016)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.584 Tw T* (\n\024\005 \022\017\001\022\017 \(\024\002\024\030 \035\017\021\036\030\ \026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\017\036 \023\030\017\n\036\030\t\).)16( )]TJ /T1_1 1 Tf 0.014 Tc -0.014 Tw T* (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_0 1 Tf 0.515 Tw [( 2022;21\(4\):100\226110. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.014 Tw (10.33878/2073-)Tj 0.016 Tc -0.016 Tw T* (7556-2022-21-4-100-110)Tj 0 0 0 1 k /GS1 gs 0.572 Tw [( / P)30.4(er)-9.6(shina)]TJ /Span<>> BDC ( )Tj EMC [(A.E., T)50.4(r)-21.7(uba)-16.7(chev)-14.6(a Y)35.3(u.L.,)16( )]TJ 0 Tc 0.083 Tw T* [(V)-16(y)-13(shegor)-31.9(od)17(tsev)]TJ /Span<>> BDC ( )Tj EMC [(D.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ul)56(tr)-32.9(asono)-16(gr)-33(aphy for sol)-31(i)-23.9(t)15(ar y r)-24(ec)-16(t)15(al)35(ul)16(cer )]TJ 0.021 Tw T* [(\(r)-24(ev)-15.9(iew and case r)-24(epor)-21.9(ts\). )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46.1(roktologia)]TJ /T1_0 1 Tf 0.021 Tw (. 2022;21\(4\):100\226110. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2022-21-4-100-110)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.465 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.846 0 Td (\215\036\030\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\213., \221\030\031\002\026\004\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\214., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0.012 Tc 0.452 Tw -1.846 -1.25 Td [(\211\035\034\021\030\026\r\031\022\024\r\026\016 \f\036\n\017\024\021\017\ \022\026 \f\024\035\017\021\026\030\027\024\005 \016\r\t \023\030\016\n\ \024\005 \022\017\001\022\017.)12( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf 0.321 Tw [(. 2024;23\(2\):68\22675. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2024-23-2-68-75)Tj 0 0 0 1 k /GS1 gs 0.338 Tw [( / P)30(er)-10(shina)]TJ /Span<>> BDC ( )Tj EMC [(A.E., T)50(r)-22(uba)-16.9(chev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(Y.L., V)29.9(esel)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (V.V., )Tj 0.219 Tw T* [(Bir)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC (O.M.,)Tj /Span<>> BDC ( )Tj EMC [(e)-12(t al. Ul)56(tr)-32.9(asound semio)17(t)-32(ics of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al)35(ul)16(cer. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.039 Tw [(. 2024;23\(2\):68\22675. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2024-23-2-68-75)Tj 0 0 0 1 k /GS1 gs 0.295 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)-14(bdel)-16(a)15.1(t)-30(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-30.9(i)-24(t)15(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syndr)-31.9(ome \(SR)12(US\): )]TJ 0.201 Tw -1.796 -1.25 Td [(obser)-32(v)-15(a)15.1(t)-32(ional case ser)-36.9(ies f)-28(indings on MR defeco)-15.9(gr)-33(aphy. )]TJ /T1_1 1 Tf 0 Tw (European )Tj 0.013 Tc -0.013 Tw T* [(R)20(adiology.)]TJ /T1_0 1 Tf 0.48 Tw [( )0.5(2021;31\(11\):8597\2268605. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw 18.571 0 Td (10.1007/s00330-021-)Tj 0 Tc 0 Tw -18.571 -1.25 Td (08075-6)Tj 0 0 0 1 k /GS1 gs 0.024 Tc 0.871 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.893 0 Td (\231\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 \030\036\022\ \024\n\036\027\007\026)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.581 Tw -1.893 -1.25 Td [(\006\017\017. )0.5(\200\t\023\026\007\036\027\017\036 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\(\02562.2, )0.6(\02562.3\) )0.5(\r\030\024\f\035\t\036.)16( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_0 1 Tf 0.321 Tw [( 2024;23\(3\):10\22622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2024-23-3-10-22)Tj 0 0 0 1 k /GS1 gs 0.168 Tw [( )0.5(/ )0.5(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC 11.984 0 Td [(Y.A., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.444 0 Td [(al. )0.5(Cl)-31(inical )0.6(guidel)-31(ines. )0.5(R)13(ec)-16(t)15(al )]TJ 0.014 Tw -15.428 -1.25 Td [(p)25(r)-32(ol)-16(apse \(62.2, 62.3\), adul)56.1(ts. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.014 Tw (. 2024;23\(3\):10\22622. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2024-23-3-10-22)Tj 0 0 0 1 k /GS1 gs 0.212 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(kno)-16(os)]TJ /Span<>> BDC ( )Tj EMC (SJ, Nicholls)Tj /Span<>> BDC ( )Tj EMC [(RJ, Henr)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(MM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Elec)-16(tr)-32(ophy)-12.9(siol)30(o)-16(gical )]TJ 0.126 Tw -1.796 -1.25 Td [(and manome)-12(tr)-36.9(ic assess)26.1(ment of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he pel)30(v)-16(ic fl)30(o)-16(or in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y r)-23.9(ec)]TJ 0 Tw (-)Tj 0.149 Tw T* [(t)15(al )0.5(ul)16(cer )0.6(syndr)-32(ome. )]TJ /T1_1 1 Tf 8.367 0 Td [(Br )0.5(J )0.5(Surg.)]TJ /T1_0 1 Tf [( )0.5(1985;72\(2\):131\226133. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 15.531 0 Td (10.1002/)Tj -23.899 -1.25 Td (bjs.1800720221)Tj 0 0 0 1 k /GS1 gs 0.006 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(or)-37(io)]TJ /Span<>> BDC ( )Tj EMC [(O, Meur)-23.9(e)-12(t)-30(te)]TJ /Span<>> BDC ( )Tj EMC [(G, Desfour)-14.9(neaux)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24(ec)-16(t)15.1(al phy)-13(siol)30.1(o)-16(g)16(y )]TJ 0.039 Tw -1.796 -1.25 Td [(in sol)-31(i)-24(t)15(ar)-24(y ul)16(cer syndr)-32(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(case-ma)15(tched ser)-37(ies. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2005;48\(10\):1917\2261922. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10350-005-0105-x)Tj 0 0 0 1 k /GS1 gs 0.255 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(uck)10(elman)]TJ /Span<>> BDC ( )Tj EMC (J, Johnson)Tj /Span<>> BDC ( )Tj EMC [(EK. \236S)-16(ol)-31(i)-24(t)15(ar)-23.9(y R)13(ec)-16(t)15(al Ul)16(cer Syndr)-32(ome\237. )]TJ 0.032 Tw -1.796 -1.25 Td [(Chapter in: Cl)-31(inical al)16(gor)-37(i)-23.9(t)-13(hms in gener)-32.9(al sur)-31.9(ger)-24(y: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-33(a)-17(c)-15.9(t)-32(ical guide. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Cham: Sp)46(r)-36.9(ing)12(er.)]TJ /T1_0 1 Tf ( 2019; pp. 269\226274)Tj 0.12 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gour)-36.9(iou)]TJ /Span<>> BDC ( )Tj EMC [(C, Chamba)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(M, R)11(oper)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic l)-31(i)-23.9(ter)-33(a)15(tur)-24(e )]TJ 0.255 Tw -1.796 -1.25 Td [(r)-24(ev)-15.9(iew on sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer syndr)-31.9(ome: is t)-12.9(her)-24(e a)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(her)-33(apeut)-32(ic )]TJ 0.218 Tw T* (consensus in 2018? )Tj /T1_1 1 Tf (Int J Colorectal Dis. 2018;)Tj /T1_0 1 Tf 0 Tw (33\(12\):1647\2261655. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-018-3162-z)Tj 0 0 0 1 k /GS1 gs 0.138 Tw -1.847 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Qar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(Y, M)-24(osl)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC (M. A)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15(a-anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.325 Tw -1.796 -1.25 Td [(ef)-56(f)-28(ica)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC [(medical tr)-23.9(ea)15(tments for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-16.9(gement of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-24(t)15(ar)-23.9(y )]TJ 0.005 Tc 0.349 Tw T* [(r)-23.7(ec)-15.7(t)15.3(al ul)16.3(cer syndr)-31.7(ome)]TJ /T1_1 1 Tf (. Saudi J Gastroenterol.)Tj /T1_0 1 Tf [( 2020;26\(1\):4\22612.)5( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4103/sjg.SJG_213_19)Tj 0 0 0 1 k /GS1 gs 0.074 Tw -1.847 -1.25 Td (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(or)-32(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M, S)-16(hek)-17(ar)-32(chizadeh)]TJ /Span<>> BDC ( )Tj EMC [(M, F)20(ar)-16(manar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biofeedba)-17(ck )]TJ 0.06 Tw -1.796 -1.25 Td [(ef)-56(f)-28(ica)-17(cy t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(im)10(p)25(r)-32(ove cl)-30.9(inical sym)10(pt)17(oms and end)-15.9(oscopic signs of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)]TJ 0 Tw (-)Tj 0.306 Tw T* [(t)15(ar)-24(y r)-24(ec)-15.9(t)15(al ul)16(cer syndr)-31.9(ome. )]TJ /T1_1 1 Tf [(Eur J T)56(ransl Myol)]TJ /T1_0 1 Tf (. 2018;28\(1\):7327. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4081/ejtm.2018.7327)Tj 0 0 0 1 k /GS1 gs 0.181 Tw -1.847 -1.25 Td (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\224., \215\024\030\016\007\017\027)Tj /Span<>> BDC ( )Tj EMC (\206.\200., \204\024\030\024\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\006\036\027\022\026 )Tj 0.012 Tc 0.455 Tw -1.796 -1.25 Td (\030\036\031\035\034\021\026\021\024\r \022\024\027\f\036\030\r\026\021\ \017\r\027\024\020\024 \035\036\004\036\027\017\016 \235\031\027\022\006\ \017\024\027\026\035\034\027\t\b \030\026\f)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.35 Tw T* (\f\021\030\024\005\f\021\r \007\036\235\036\022\026\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\026\023\f\024\n \021\026\024\r\t\b \024\030\020\026)Tj 0 Tc 0 Tw (-)Tj 0.001 Tc -0.001 Tw T* (\027\024\r. )Tj /T1_1 1 Tf 0.35 Tw 2.37 0 Td (\004\020\023\031\f\031\b\022\007\027\024\n\020\t \203\022\016\022\031\f\031\ \b\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\204\n\024\033\027\032\022\026\027\025\023\020\f\017\025\020\t \023\027\032\ \020)Tj 0 Tc 0 Tw (-)Tj -2.37 -1.25 Td (\033\022\t)Tj /T1_0 1 Tf 0.094 Tw [(. 2021;65\(2\):44\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.25557/0031-2991.2021.02.44-52)Tj 0 0 0 1 k /GS1 gs 0.094 Tw /Span<>> BDC ( )Tj EMC (/ )Tj 0.117 Tw T* [(F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(O.Y)35(u., P)10(or)-24(y)22(adin)]TJ /Span<>> BDC ( )Tj EMC [(G.V., M)-24(or)-32(ozov)]TJ /Span<>> BDC ( )Tj EMC [(S.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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\202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.221 Tw 10 0 0 10 42.5197 724.8299 Tm [(\n\036\032\007\031 )0.5(\024\002\255\201\n\024\n, )0.6(\022\024\035\017\004\036\f\021\r\024\n )0.5(\204\222\025-\240\221 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 17.778 0 Td (\f\022\024\030\024\f\021\034\033 )Tj 0.078 Tw -17.778 -1.218 Td [(\026\032\017\r\035\036\027\017\016 )0.5(\023\024\f\021\035\031\004\036\r\t\b \023\024\r\030\036\032\007\036\027\017\ \005 \023\030\016\n\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj -0.018 Tw 0 -1.218 TD (\022\017 \r\t\016\r\035\036\027\024 \027\036 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\033\007\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (100% \f\035\031\004\026\036\r )Tj 0.055 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (84 \007\027\036\005, \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\t\036 \024\f\035\024\032)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (79,2% \f\035\031\004\026\036\r)Tj /T1_2 1 Tf (.)Tj /T1_1 1 Tf 0.618 Tw 0 -1.218 TD [(\204\036\021\026\026\027\026\035\017 )0.5(\035\017\021\036\030\026\021\031\030\t, \023\030\024\r\036\007\036\027\027\ \t\005 Cheng F., )]TJ 0.079 Tw 0 -1.218 TD (Huang Z. \017)Tj /Span<>> BDC ( )Tj EMC [(L)-32(i Z. \(2020\) [76])]TJ /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.079 Tw 12.027 0 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\033 \220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.203 Tw -12.027 -1.218 Td (\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \021\024\023\017\004\036\f\022\ \024\005 \021\036\030\026\023\017\017 \204\222\025-\240\221 )Tj 0.155 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\035\024\032\027\t\b )0.5(\f\r\017\013\026\b, )0.5(\023\024\022\026\026\035 \r\t\f\024\022\017\005 )0.5(\023\030\024\006\036\027\021 \026)]TJ 0 Tw (-)Tj -0.007 Tw T* (\032\017\r\035\036\027\017\016. \215\024\035\027\026\016 \030\036\220\023\ \017\021\036\035\017\026\006\017\016 \027\026\030\031\032\027\024\020\024\ \024\021\r\036\030)Tj 0 Tw (-)Tj -0.087 Tw T* (\f\021\017\016 \f\r\017\013\036\r\t\b \b\024\007\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \204\222\025-\240\221 \027\026\002\ \035\033)Tj 0 Tw (-)Tj 0.13 Tw T* (\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (50,6% \023\030\024\021\017\r 34,4% \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 )Tj 0.072 Tw T* (\(\023\035\026\006\036\002\024\), \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\030\017\n\036\027\036\027\017\017 \204\222\025-\240\221\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 )Tj -0.018 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\017\027\024\r\t\n \022\035\036\036\n)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (51,6% \023\030\024\021\017\r 29,6% \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021)Tj 0 Tw (-)Tj 0.112 Tw T* (\030\024\035\034\027\024\005 \020\030\031\023\023\036 \(\021\024\035\034\ \022\024 \235\017\002\030\017\027\024\r\t\005 \022\035\036\005\). \233\235\ \235\036\022\021 )Tj 0.135 Tw T* (\021\036\030\026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \204\222\025-\240\221 \026\035\035\ \024\020\036\027\027\024\020\024 \023\030\024)Tj 0 Tw (-)Tj -0.026 Tw T* (\017\f\b\024\032\007\036\027\017\016 \f\024\f\021\026\r\017\035 53,4%, \026\ \031\021\024\035\024\020\017\004\027\024\020\024)Tj /Span<>> BDC ( )Tj EMC (\227 47,3%)Tj /T1_2 1 Tf 0 Tw (.)Tj /T1_1 1 Tf 0.079 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \f\017\f\021\036\n\026\021\ \017\004\036\f\022\024\020\024 \035\017\021\036\030\026\021\031\030\027\024\ \020\024 \024\002)Tj 0 Tw (-)Tj 0.273 Tw T* (\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026, \r\t\023\024\035\027\036\027\027\ \024\020\024 \202\027\024\f\024\r\t\n)Tj /Span<>> BDC ( )Tj EMC (\230.\222. )Tj 0.292 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.042 0 Td [(\f\024\026\r\021. )0.5(\(2024\), )0.6(\023\030\017\n\036\027\036\027\017\036 )0.6(\204\222\025-\240\221 )0.5(\026\035\035\024\020\036\027\027\024\020\024 )]TJ 0.113 Tw -1.042 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\026\031\021\024\035\024\020\017\004\027\024\020\024 \023\030\024\017\f\b\ \024\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\n \035\036\004\036\027\017\017 )Tj -0.013 Tw T* (\023\036\030\017\026\027\026\035\034\027\t\b \023\024\030\026\032\036\027\ \017\005 \(\f\r\017\013\017, \016\r\t\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\017 )Tj -0.003 Tw T* (\025\030\024\027\026 \016\r\035\016\036\021\f\016 \220\235\235\036\022\021\ \017\r\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\t\n \n\036\021\024\007\024\n )Tj 0.197 Tw T* (\021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n\017 \026\032\017\r\035\036\027\017\ \016 \024\021 50 \007\024)Tj /Span<>> BDC ( )Tj EMC (80% )Tj 0.127 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036\n \f\027\017\032\036\027\017\016 \220\ \235\235\036\022\021\017\r\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036\n )Tj 0 Tw T* (\r\030\036\n\036\027\017 [77].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 286.4218 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.2 Tw 10 0 0 10 42.5197 262.0658 Tm (\221\026\022\017\n \024\002\030\026\024\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034, \024\002\013\ \036\020\024 \022\024\027)Tj 0 Tw (-)Tj -0.026 Tw T* (\f\036\027\f\031\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \222\222\242\215\025 \027\036\021, \007\026\ \027\027\t\036 \017\f\f\035\036\007\024\r\026\027\017\005 )Tj 0.234 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\ \017 \021\024\020\024 \017\035\017 \017\027\024\020\024 \n\036\021\024\007\ \026 )Tj 0.185 Tw T* (\035\036\004\036\027\017\016 \r\026\030\034\017\030\031\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\017\b \023\030\036\007\036\035\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\036\007\022\024 )Tj 0.038 Tw T* [(\024\020\030\026\027\017\004\036\027\t \n\026\035\024\005 )0.5(\r\t\002\024\030\022\024\005 \023\026\006\017\036\027\021\024\r, )0.5(\024\021\f\031\021\f\021\r\017\036\n )]TJ -0.028 Tw T* [(\024\021\007\026\035\201\027\027\t\b )0.6(\030\036\031\035\034\021\026\021\024\r. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 11.27 0 Td [(\007\024\f\021\031\023\027\024\005 )0.5(\027\026\n )0.6(\035\017\021\036\030\026\021\031\030\036 )]TJ -0.053 Tw -11.27 -1.218 Td (\027\036 \024\002\027\026\030\031\032\036\027\024 \023\031\002\035\017\022\ \026\006\017\005 \024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \222\222\242\215\025 \n\036\021\024\007\024\ \n )Tj 0.246 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \026\031\021\024\ \021\030\026\027\f\023\035\026\027\021\026\006\017\017 \204\222\025-\240\ \221 \(\035\017)Tj 0 Tw (-)Tj 0.091 Tw T* (\023\024\235\017\035\017\027\020\). \212\026\027\027\t\005 \n\036\021\024\ \007 \035\036\004\036\027\017\016 \222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj -0.034 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\005 \030\036\022\021\026\035\034\027\024\ \005 \017\027\r\026\020\017\027\026\006\017\036\005 1 \f\021\036\023\036\ \027\017 )Tj -0.009 Tw 23.244 57.237 Td (\017\035\017 \002\036 \027\036\201 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\026\030\031\032\027\024\020\024 \r\t\023\026\007\036\027\017\ \016 \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.146 Tw 0 -1.218 TD (\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\027\026\001\036\n\031 )0.5(\n\027\036\027\017\033, )0.5(\n\024\032\036\021 \002\t\021\034 )0.5(\023\036\030\f\023\036\022\021\017\r\027\t\n, )]TJ 0.7 Tw 0 -1.218 TD (\031\004\017\021\t\r\026\016 \b\030\024\027\017\004\036\f\022\017\005 \r\ \024\f\023\026\035\017\021\036\035\034\027\t\005 \023\030\024\006\036\f\f\ )Tj 0.189 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \026\002\024\035\036\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\022\026\026\027\027\t\005 \030\036\020\036\027\036\030\017\030\ \031\033)Tj 0 Tw (-)Tj 0 -1.218 TD (\013\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\n\024\007\031\035\017\030\031\033\013\017\005 \023\024\ \021\036\027\006\017\026\035 \204\222\025-\240\221.)Tj 0.487 Tw 0 -1.218 TD (\215\030\017\027\017\n\026\016 \r\024 \r\027\017\n\026\027\017\036 \r\024\ \n\024\032\027\024\f\021\034 \022\024\030\024\021\022\024\007\017)Tj 0 Tw (-)Tj 0.205 Tw 0 -1.218 TD [(\f\021\026\027\021\027\024\005 \026\007\030\036\f\027\024\005 )0.5(\n\017\020\030\026\006\017\017 \204\222\025-\240\221, \f\023\030\024\r\024\ \006\017\030\024)]TJ 0 Tw (-)Tj 0.303 Tw 0 -1.218 TD (\r\026\027\027\024\005 \r\t\002\030\024\f\024\n \b\036\n\024\022\017\027\ \024\r \023\024\r\030\036\032\007\201\027\027\024\005 \021\022\026\027\017\ )Tj -0.011 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\024\f\021\034 \f\023\024\f\024\002\026 \007\024\f\021\026\ \r\022\017 \022\035\036\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\026\007\026\027\027\t\005 \022\024\n)Tj 0 Tw (-)Tj 0.061 Tw T* (\023\026\030\021\n\036\027\021 \024\030\020\026\027\017\n\026, \027\026\ \017\002\024\035\036\036 \023\030\017\036\n\035\036\n\t\n \n\036\021\024\ \007\024\n )Tj -0.009 Tw T* (\r\r\036\007\036\027\017\016 \204\222\025-\240\221 \n\024\032\036\021 \002\ \t\021\034 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\005 [78]\ .)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.259 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC 6.074 0 Td [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 )0.5(\017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-18.9(\007)-4.5(\024)-4.2(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.008 Tc 0.267 Tw [( )0.5(\035)6.6(\022\n)-25.8(\r)-5.9(\023)-4(\031)1.6(\021)]TJ /Span<>> BDC 13.683 0 Td ( )Tj EMC 0.492 0 Td [(\003)-10.3(.)-0.7(\003)-10.3(.,)-7.9( )]TJ -0.029 Tc 0.029 Tw -20.249 -1.218 Td [(\205)-24.5(\n)-27(\032)-22.6(\022)-22.4(\030)-11(\f)-25.7(\027)-22.4(\021)-30.3(\024)-25(\n)-16.3(\022)-18.9(\235)]TJ /Span<>> BDC 5.531 0 Td ( )Tj EMC [(\205)-31.1(.\001.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -5.531 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_2 1 Tf -0.004 Tc 0.004 Tw [( \221)-2.8(\031)1.9(\b\030)0.8(\020\025\031)5.6(\021)-1.9(\020)]TJ /Span<>> BDC 17.239 0 Td ( )Tj EMC [(\036)18.8(.)3.3(\003)-6.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -17.239 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf -0.004 Tc 0.004 Tw 7.694 0 Td [( \221)-2.9(\031)1.9(\b\030)0.8(\020\025\031)5.6(\021)-1.9(\020)]TJ /Span<>> BDC 4.5 0 Td ( )Tj EMC [(\036)18.8(.)3.3(\003)-6.3(.)3.9(,)-4( \205)0.5(\n)-2(\032)2.4(\022)2.6(\030)14(\f)-0.7(\027)2.6(\021)-5.2(\024\n)8.7(\022)6.1(\235)]TJ /Span<>> BDC 7.773 0 Td ( )Tj EMC [(\205)-6.1(.)25.3(\001)24.8(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -19.967 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.002 Tc -0.002 Tw [( \035)16.6(\022)9.7(\n)-15.8(\r)4.1(\023)6(\031)11.6(\021)]TJ /Span<>> BDC 10.989 0 Td ( )Tj EMC [(\003.)9.3(\003.)]TJ /T1_4 1 Tf 0 Tc 0.023 Tw -10.989 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.161 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.2(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, )]TJ -0.003 Tc 0.003 Tw T* [(S)2.6(e)-4.7(r)-0.7(g)-5.5(e)-5.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC [(N)10(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(S)11.8(kr)-38.3(idl)1.8(e)-7(v)-6.9(s)6.1(k)-21.5(i)-3(y)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -3.655 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -0.005 Tc 0.005 Tw -15.798 -1.218 Td [(E)14.6(le)-7.6(na)]TJ /Span<>> BDC 2.132 0 Td ( )Tj EMC [(A)-17.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(B)-4.2(o)-9.4(g)-7.5(d)-3.1(a)-5.8(n)-3.1(o)-5.6(v)5.8(a)]TJ /T1_1 1 Tf 0 Tc 0.996 Tw -3.212 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.8(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf [( E)19.6(l)4.8(e)-2.5(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(o)-4.4(g)-2.5(d)1.9(a)-0.8(n)1.9(ov)10.8(a)-14(, )]TJ -0.003 Tc 0.003 Tw T* [(S)2.6(e)-4.7(r)-0.7(g)-5.5(e)-5.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC [(N)10(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(S)11.8(kr)-38.3(idl)1.8(e)-7(v)-6.9(s)6.1(k)-21.5(i)-3(y)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -3.655 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( A)3.6(l)4.8(ek)-17.4(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.1(i)7.9(k)12.5(ut)1.4(o)-0.6(v)]TJ /T1_4 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.373 Tw T* (\207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213\035\036\027\026 \202\035\036\022\f\026\027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026)Tj 0 Tw (-)Tj 0.543 Tw T* (\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\ \026 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\017\026\ \020)Tj 0 Tw (-)Tj 0.414 Tw T* (\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\017 \205\206\207\211 \253\203\204\230\037 \022\ \024\035\024\023\030\024\022\021\024\035\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0009-0009-1982-2200)Tj 0.331 Tw T* (\222\022\030\017\007\035\036\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\222\036\030\020\036\005 \203\017\022\024\035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030)Tj 0 Tw (-)Tj 0.422 Tw T* (\001\017\005 \027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022\ \024\021\007\036\035\026 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 )Tj 0.24 Tw T* [(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.634 0 Td [(\b\017\030\031\030\020\017\017 )0.6(\205\206\207\211 )0.5(\253\203\204\230\037 )0.6(\022\024\035\024\023\030\024\022\021\024)]TJ 0 Tw (-)Tj 0.088 Tw -6.634 -1.218 Td (\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0001-8871-1891)Tj 0.003 Tw T* (\214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202\035\036\022\f\036\005 \202\035\036\022\f\026\027\007\030\024\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \030\031\022\024\r\024\007\017)Tj 0 Tw (-)Tj -0.064 Tw T* [(\021\036\035\034 )0.5(\024\021\007\036\035\026 )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 )0.6(\007\017\026\020\027\024\f\021\017\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.293 0 Td (\b\017\030\031\030\020\017\017 )Tj 0.221 Tw -18.293 -1.218 Td (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017; ORCID 0000-0001-5848-4050)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (Elena)Tj /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(Bo)-15.9(gd)42(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0009-1982-2200)Tj T* [(Ser)-32(ge)-11(y)]TJ /Span<>> BDC ( )Tj EMC (N.)Tj /Span<>> BDC ( )Tj EMC [(S)-15.9(kr)-37(idlevsk)-15.9(iy)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8871-1891)Tj T* [(Alek)-10(se)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(L)-31.9(ikut)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5848-4050)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 115.9299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCE)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.25 Tw 8 0 0 8 42.5197 103.0952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cr)-22(uveilhier)]TJ /Span<>> BDC ( )Tj EMC [(J. Ana)15.1(t)17(omie p)32(a)15(t)-12.9(hol)30(o)-16(gique du cor)-23.9(ps humain. P)40(ar)-36.9(is: )]TJ 0.023 Tw -1.296 -1.25 Td [(Baill)-30.9(ier)-24(e, Jean Bapt)-31.9(iste, 1829.)]TJ 0.35 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Madigan)Tj /Span<>> BDC ( )Tj EMC [(MR, M)-24.2(or)-10.2(son)]TJ /Span<>> BDC ( )Tj EMC [(BC. S)-16.2(ol)-31.1(i)-24.2(t)14.9(ar)-24.1(y ul)15.9(cer of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.2(he r)-24.2(ec)-16.2(tum. )]TJ /T1_2 1 Tf 0 Tw (Gut)Tj /T1_1 1 Tf (. )Tj 0.023 Tw 27.759 2.5 Td [(1969;10:871\226881. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/gut.10.11.871)Tj 0 0 0 1 k /GS1 gs 0.331 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(K.R. S)-16(ol)-31(i)-24(t)15(ar)-23.9(y r)-24(ec)-16(t)15(al ul)16(cer syndr)-32(ome. )]TJ /T1_2 1 Tf (Proc R Soc Med. )Tj /T1_1 1 Tf 0 Tw -1.296 -1.25 Td (1975;68\(1\):22\22626.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4895 56.0378 Tm (163)Tj ET endstream endobj 514 0 obj <>/Border[0 0 0]/H/N/Rect[351.461 110.391 427.436 101.095]/Subtype/Link/Type/Annot>> endobj 515 0 obj <> endobj 359 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.028 Tw 10 0 0 10 70.8661 724.8299 Tm (\021\024\035\f\021\024\005 \022\017\001\022\017, \026\022\035\033\004\026\ \033\013\017\005\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \024\023\036\030\026)Tj 0 Tw (-)Tj -0.001 Tw 0 -1.218 TD [(\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.481 0 Td [(\024\002\255\201\n\036 )0.5(\022\024\035\220\022\021\024\n\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 8.954 0 Td [(\030\036\036\022\006\017\036\005 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, )]TJ 0.18 Tw -11.435 -1.218 Td [(\021\030\026\027\f\026\027\026\035\034\027\024\005 )0.5(\007\036\n\031\022\024\026\006\017\017 \024\f\021\026\r\001\036\005\f\016\ \004\026\f\021\017 \023\030\016)]TJ 0 Tw (-)Tj 0.223 Tw T* (\n\024\005 \022\017\001\022\017 \(6\2268 \f\n\) \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \220\027\007\024\f\022\024\023\017\ \004\036)Tj 0 Tw (-)Tj 0.074 Tw T* (\f\022\017\n \r\r\036\007\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\t\005 \022\026\030\022\026\f \026\n\023\031\035\t \023\ \030\016\n\024\005 )Tj 0.035 Tw T* (\022\017\001\022\017 \f\031\n\n\026\030\027\024\005 \022\031\035\034\021\ \031\030\t \235\036\021\026\035\034\027\t\b \f\024\n\026\021\017\004\036\ \f\022\017\b )Tj 0.069 Tw 0 -1.218 TD (\022\035\036\021\024\022 \022\017\001\036\004\027\024\020\024 \220\023\017\ \021\036\035\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\036\027\b\017\n\026\035\034\027\t\b \f\021\030\024)Tj 0 Tw (-)Tj 0.037 Tw 0 -1.218 TD (\n\026\035\034\027\t\b \022\035\036\021\024\022 \020\036\023\026\021\024\ \006\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017)Tj 0 Tw (-)Tj 0.061 Tw T* (\r\036\027\027\t\n \r\r\036\007\036\027\017\036\n \204\222\025-\025\204 \ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\022\024\032\027\t\n \r\r\036\007\036\027\017\036\n )Tj 0.132 Tw T* (\002\017\024\035\024\020\017\004\036\f\022\017 \026\022\021\017\r\027\t\b\ \030\024\f\021\024\r\t\b \235\026\022\021\024\030\024\r \235\036\021\026\ \035\034)Tj 0 Tw (-)Tj 0.432 Tw T* [(\027\024\020\024 \023\030\024\017\f\b\024\032\007\036\027\017\016 )0.5(\007\035\016 \031\f\022\024\030\036\027\017\016 \030\036\020\036\027\036\ \030\026\006\017\017 )]TJ 0.131 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \024\f\021\ \026\r\001\036\005\f\016 \004\026\f\021\017 \023\030\016\n\024\005 \022\017\ \001)Tj 0 Tw (-)Tj 0.006 Tw 0 -1.218 TD (\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\036 \024\021\n\036\004\036\027\024, \004\021\024 \023\ \024\035\027\026\016 \220\023\017\021\036\035\017\026\006\017\016 \f\035\ \017)Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD (\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\016\n\024\005\ \022\017\001\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \220\027)Tj 0 Tw (-)Tj 0.079 Tw 0 -1.218 TD [(\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\ \024\r\026\027\017\016, )0.5(\027\026\002\035\033\007\026\035\026\f\034 \r)]TJ /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 )Tj 0.105 Tw T* (\024\021 8 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \027\036\007\036\035\034, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\017\n\024\005 \020\030\031\023\023\036 )Tj 0.328 Tw T* [(\023\026\006\017\036\027\021\024\r )0.5(\002\036 )0.6(\026\035\035\024\021\030\026\027\f\023\035\026\027\021\026\006\017\017 )0.6(\030\036\022\024\027\f\021\030\031\022\006\017\016 )]TJ -0.038 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\024\ \017\024\001\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \024\021 9 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \n\036)Tj 0 Tw (-)Tj 0.005 Tw T* (\f\016\006\036\r. \210\f\035\024\032\027\036\027\017\005, \f\r\016\026\027\ \027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\035\035\024\021\030\026\027\f\023\035\026\027\021\026\006\017)Tj 0 Tw (-)Tj 0.021 Tw T* (\036\005 \222\025, \027\036 \027\026\002\035\033\007\026\035\024\f\034 \022\ \026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.05 Tw T* (\027\t\036 \(120 \n\036\f\016\006\036\r\) \f\030\024\022\017 [61].)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.05 Tw 13.101 0 Td (\230\f\021\024\004\027\017\022\026\n\017 \204\222\025-\025\204 )Tj 0.167 Tw -13.101 -1.218 Td [(\016\r\035\016\036\021\f\016 )0.6(\f\021\030\024\n\026 )0.5(\022\024\f\021\027\024\020\024 )0.5(\n\024\020\026. )0.5(\204\222\025-\025\204 )0.5(\r\t\007\036\035\016\033\021 )]TJ 0.221 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\021\027\024\n\024\020\024\r\t\b \026\f\023\017\030\026\021\024\ \r \020\030\036\002\027\016 \023\024\007\r\007\024\001\027\024\005 )Tj 0.337 Tw T* (\022\024\f\021\017. \212\026\027\027\026\016 \024\023\036\030\026\006\017\ \016 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \r\t\f\024\022\024\ \005 )Tj -0.022 Tw T* (\017\027\r\026\017\r\027\024\f\021\034\033, \030\017\f\022\024\n \024\f\ \035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\t\n \022\024\035\017\004\036)Tj 0 Tw (-)Tj 0.014 Tw T* (\f\021\r\024\n, \023\024\035\031\004\026\036\n\t\b \204\222\025-\025\204\ \(\r \023\024\023\031\035\016\006\017\017 \022\026\030\017\024\006\017\021\ \024\r )Tj -0.02 Tw T* (\022\024\f\021\027\024\020\024 \n\024\020\026 \204\222\025-\025\204 \f\024\ \f\021\026\r\035\016\033\021 0,001\2260,01%\), \004\021\024 )Tj -0.005 Tw T* (\026\004\026\f\021\031\033 \021\030\036\002\031\036\021 \023\024\r\021\024\ \030\027\024\020\024 \026\002\024\030\026 \022\024\f\021\027\024\n\024\ \020\024\r\t\b )Tj -0.023 Tw T* [(\026\f\023\017\030\026\021\024\r )0.5(\017\035\017 )0.6(\022\031\035\034\021\017\r\017\030\024\r\026\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.256 0 Td [(\030\026\n\027\024\032\036\027\017\016 )0.6(\204\222\025-)]TJ 0.206 Tw -14.256 -1.218 Td (\025\204 \r)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\024\030\026\021\024\030\027\t\b \031\f\035\024\r\017\016\b.\ \233\021\024 \016\r\035\016\036\021\f\016 \r\036\f\034\n\026 )Tj 0.154 Tw T* (\f\035\024\032\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\036\030\017\026\035\034\027\024 \026\021\030\026\021\027\024\ \005 \026\007\026\004\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.07 Tw T* (\021\024\020\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\035\035\024\020\036\027\027\024\005 \021\030\026\027\f\023\035\026\027\ \021\026\006\017\017 \021\030\036\002\031\036\021\f\016 \023\024\007)Tj 0 Tw (-)Tj T* (\002\024\030 \017\007\036\027\021\017\004\027\024\020\024 \023\024)Tj /Span<>> BDC ( )Tj EMC [(HL)-34.8(A \007\024\027\024\030\026 [62].)]TJ 0.16 Tw T* (\202\035\034\021\036\030\027\026\021\017\r\027\t\n \017\f\021\024\004\027\ \017\022\024\n \204\222\025 \016\r\035\016\036\021\f\016 \023\024\007\022\ \024\032)Tj 0 Tw (-)Tj 0.316 Tw T* [(\027\026\016 )0.5(\032\017\030\024\r\026\016 )0.6(\021\022\026\027\034 )0.5(\(\240\221\). )0.5(\025\026\030\021\t )0.6(\220\022\f\023\030\036\f\f\017\030\031\036\n\t\b )]TJ 0.196 Tw T* [(\020\036\027\024\r )0.5(\204\222\025 )0.6(\032\017\030\024\r\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.269 0 Td [(\022\024\f\021\027\024\n\024\020\024\r\024\020\024 )0.6(\023\030\024\017\f\b\024\032)]TJ 0 Tw (-)Tj 0.23 Tw -10.269 -1.218 Td (\007\036\027\017\016 \023\030\026\022\021\017\004\036\f\022\017 \017\007\ \036\027\021\017\004\027\t [63]. \204\222\025 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\030\024)Tj 0 Tw (-)Tj 0.083 Tw T* (\r\024\005 \021\022\026\027\017 \(\204\222\025-\240\221\) \r\023\036\030\ \r\t\036 \002\t\035\017 \r\t\007\036\035\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\b\026)Tj 0 Tw (-)Tj 0.238 Tw T* (\030\026\022\021\036\030\017\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC [(2001 \020\024\007\031 Z)20(uk P.A. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [64])Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.013 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\027\024\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC [(\007\017\235\235\036\030\036\027\006\017\030\024\r\022\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b )0.5(\027\026)]TJ 0 Tw (-)Tj 0.07 Tw T* [(\023\030\026\r\035\036\027\017\016\b )0.5(\(\220\022\021\024\007\036\030\n\026\035\034\027\024\n, \220\027\021\024\ \007\036\030\n\026\035\034\027\024\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj T* (\024\007\036\030\n\026\035\034\027\024\n\))Tj /T1_1 1 Tf (. )Tj /T1_0 1 Tf 0.197 Tw 7.018 0 Td (\212\024\022\026\026\027\024, \004\021\024 \204\222\025-\240\221 \f\036\ \022\030\036\021\017\030\031\036\021 )Tj 0.409 Tw -7.018 -1.218 Td [(\006\017\021\024\022\017\027\024\r\t\005 )0.5(\023\030\024\235\017\035\034, )0.5(\r\022\035\033\004\026\033\013\017\005 )0.6(\026\027\020\017\024\020\036\027\027\t\036, )]TJ 0.638 Tw T* [(\026\027\021\017\024\022\f\017\007\026\027\021\027\t\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.49 0 Td [(\017\n\n\031\027\024\f\031\023\030\036\f\f\017\r\027\t\036 )0.6(\235\026\022\021\024)]TJ 0 Tw (-)Tj 0.209 Tw -9.49 -1.218 Td (\030\t, \027\036\024\002\b\024\007\017\n\t\036 \007\035\016 \017\027\007\ \031\022\006\017\017 \r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\ \t\b )Tj 0.201 Tw T* (\023\030\024\006\036\f\f\024\r [67,68]. \212\026\027\027\t\005 \022\024\n\ \023\035\036\022\f \002\017\024\035\024\020\017\004\036\f\022\017 )Tj 0.09 Tw T* [(\026\022\021\017\r\027\t\b )0.6(\r\036\013\036\f\021\r )0.5(\024\023\030\036\007\036\035\016\036\021 )0.5(\f\023\024\f\024\002\027\024\f\021\034 )0.6(\204\222\025 )0.5(\f\021\017)]TJ 0 Tw (-)Tj 0.505 Tw T* (\n\031\035\017\030\024\r\026\021\034 \027\036\024\r\026\f\022\031\035\016\ \030\017\026\006\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\017\235\036\030\026\006\017\033 )Tj -0.014 Tw T* (\022\035\036\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \023\024\r\030\036\032\007\036\027\017\016 [67]. \025\030\024\ \n\036 \021\024\020\024, \204\222\025-\240\221 )Tj 0.304 Tw T* (\027\036 \r\t\t\r\026\033\021 \027\036\002\035\026\020\024\023\030\017\016\ \021\027\t\b \017\n\n\031\027\027\t\b \030\036\026\022\006\017\005 )Tj 0.073 Tw T* [(\017-\026 \024\021\f\031\021\f\021\r\017\016 HL)-34.9(A-DR, \023\024\007\026\r\035\036\027\017\016 \023\030\024\035\017\235\036\ \030\026\006\017\017 )]TJ 0.212 Tw T* [(\035\017\n\235\024\006\017\021\024\r, )0.6(\017\027\020\017\002\017\030\024\r\026\027\017\016 )0.6(\f\036\022\030\036\006\017\017 )0.5(\023\030\024\r\024\f\023\026\035\017)]TJ 0 Tw (-)Tj 0.234 Tw T* [(\021\036\035\034\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.784 0 Td [(\f\021\017\n\031\035\017\030\024\r\026\027\017\016 )0.6(\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\t\ \b )]TJ 0.252 Tw -4.784 -1.218 Td (\006\017\021\024\022\017\027\024\r [67,68]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \027\036\024\023\035\026\f\021\017\004\ \036\f\022\024\020\024 )Tj 0.533 Tw 23.244 64.543 Td (\023\024\021\036\027\006\017\026\035\026 \204\222\025-\240\221 \f\031\013\ \036\f\021\r\031\033\021 \023\030\024\021\017\r\024\030\036\004\017\r\t\036\ )Tj 0.163 Tw T* [(\007\026\027\027\t\036, )0.5(\023\024\022\026\t\r\026\033\013\017\036, )0.6(\004\021\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.081 0 Td [(\024\007\027\017\b )0.5(\220\022\f\023\036\030\017\n\036\027\021\026\b )]TJ 0.112 Tw -13.081 -1.218 Td (\204\222\025-\240\221 \n\024\020\031\021 \f\023\024\f\024\002\f\021\r\024\ \r\026\021\034 \030\024\f\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024)Tj 0 Tw (-)Tj 0.161 Tw T* (\r\026\027\017\033 \024\023\031\b\024\035\017, \026)Tj /Span<>> BDC ( )Tj EMC (\r \007\030\031\020\017\b, \027\026\024\002\024\030\024\021,)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\007\026\r\035\016\021\034 )Tj 0.289 Tw T* [(\030\026\r\017\021\017\036 \024\023\031\b\024\035\036\r\024\020\024 )0.5(\023\030\024\006\036\f\f\026 [69,70]. \206\035\026\r\027\t\n\017 )]TJ 0.737 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\026\n\017 \204\222\025-\240\221 \024\ \021\027\024\f\017\021\036\035\034\027\024 \204\222\025-\025\204 )Tj 0 Tw 0 -1.218 TD (\f\035\036\007\031\033\013\017\036:)Tj 0.308 Tw 0 -1.218 TD (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\024\035\034\001\036\036 \022\024\035\017\004\036\f\021\r\024 \023\024\ \035\031\004\026\036\n\t\b \204\222\025 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\036)Tj 0 Tw (-)Tj 0.212 Tw -1.296 -1.218 Td (\027\017\021\024\030\027\t\b \022\035\036\021\024\022 \023\030\036\007\001\ \036\f\021\r\036\027\027\017\006. \200\024 \235\030\026\022\006\017\017 \ \240\221 )Tj 0.347 Tw T* (\f\024\007\036\030\032\017\021\f\016 0,5\2262,0)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 413.5784 618.5578 Tm (6 )Tj 0.347 Tw 10 0 0 10 419.8732 615.2278 Tm (\016\007\030\024\f\024\007\036\030\032\026\013\017\b \022\035\036\021\024\ \022 )Tj -0.023 Tw -11.657 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\n\n \021\022\026\027\017, \204\222\025-\240\221 1\22610% \r\ )Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\024\f)Tj 0 Tw (-)Tj -0.043 Tw T* (\021\024\016\027\017\016 \023\026\006\017\036\027\021\026, \036\020\024 \ \r\024\030\026\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\026 \026\002\024\030\026 \n\026\021\036\030\017)Tj 0 Tw (-)Tj 0.026 Tw 0 -1.218 TD [(\026\035\026, )0.5(\021\024 )0.5(\036\f\021\034 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.169 0 Td [(100 )0.5(\020\030\026\n\n )0.5(\240\221 )0.5(\023\024\035\031\004\026\036\021\f\016 )0.6(0,5\22620)]TJ /Span<>> BDC ( )Tj EMC 13.895 0 Td (\327)Tj /Span<>> BDC ( )Tj EMC 0.754 0 Td (10)Tj 0 Tw 5.83 0 0 5.83 521.4944 582.0239 Tm (6 )Tj -0.026 Tw 10 0 0 10 303.3071 566.5158 Tm (\204\222\025-\240\221, \004\021\024 \023\030\036\r\t\001\026\036\021 \022\ \024\035\017\004\036\f\021\r\024 \023\024\035\031\004\026\036\n\t\b \204\ \222\025-)Tj 0 Tw 0 -1.218 TD (\025\204 \017)Tj /Span<>> BDC ( )Tj EMC (\025\204 \r)Tj /Span<>> BDC ( )Tj EMC (500 \030\026 [71,72].)Tj 0.323 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\035\036\021\024\004\027\t\036 \235\030\026\022\006\017\017, \r\t\007\ \036\035\036\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\240\221, \n\024\020\031\021 )Tj 0.436 Tw -1.296 -1.218 Td (\002\t\021\034 \017\f\023\024\035\034\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ \002\036 )Tj 0.113 Tw T* [(\f\021\026\007\017\017 \022\031\035\034\021\017\r\017\030\024\r\026\027\017\ \016 )0.5([73,74]. \210\021\f\031\021\f\021\r\017\036 \022\031\035\034\021\017)]TJ 0 Tw (-)Tj 0.097 Tw T* (\r\017\030\024\r\026\027\017\016 \023\030\036\007\024\021\r\030\026\013\026\ \036\021 \030\017\f\022 \r\024\027\017\022\027\024\r\036\027\017\016 \022\ \024\027)Tj 0 Tw (-)Tj 0.042 Tw T* (\021\026\n\017\027\026\006\017\017 \022\035\036\021\024\004\027\024\020\024\ \n\026\021\036\030\017\026\035\026 \023\026\021\024\020\036\027\027\024\ \005 \n\017\022\030\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\235\035\024\030\024\005, \020\036\027\036\021\017\004\036\f\022\024\005\ \021\030\026\027\f\235\024\030\n\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\027\021\026\027\027\024\005 )Tj 0 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 \022\035\036\021\ \024\022 [71].)Tj -0.089 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\204\026\035\026\016 \017\027\r\026\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\005 \030\017\f\022 \030\026\r\017\021\ \017\016 )Tj 0.154 Tw -1.296 -1.218 Td (\024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\002\024\030\036 \n\026\021\036\030\017\026\035\026. \214\017\023\024\ \026\f\023\017\030\026\006\017\016 )Tj -0.011 Tw T* (\023\030\024\r\024\007\017\021\f\016 \023\024\007 \n\036\f\021\027\024\005\ \017\035\017 \017\027\235\017\035\034\021\030\026\006\017\024\027\027\024\ \005 \026\027\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\021\036\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\n \002\024\035\036\r\t\n \f\017\027\007\ \030\024\n\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f)Tj 0 Tw (-)Tj 0.016 Tw T* (\022\024\n\235\024\030\021\024\n \007\035\016 \023\026\006\017\036\027\021\ \026, \001\017\030\024\022\024 \023\030\017\n\036\027\016\036\021\f\016,\ \f\021\026\027)Tj 0 Tw (-)Tj T* (\007\026\030\021\017\017\030\024\r\026\027\026, \023\030\024\f\021\026 \ \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\027\036\027\017\017 [72].)Tj 0.321 Tw T* [(\221\036\030\026\023\036\r\021\017\004\036\f\022\026\016 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\204\222\025-\240\221 )0.5(\007\024\022\026\026\027\026 )]TJ 0.188 Tw T* (\030\016\007\024\n \007\024\022\035\017\027\017\004\036\f\022\017\b \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\ \017\005 )Tj 0.16 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.867 0 Td [(\030\026\035\017\004\027\t\b )0.6(\027\026\023\030\026\r\035\036\027\017\016\b )0.6(\n\036\007\017\006\017\027\t: )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.818 0 Td (\035\036\004\036\027\017\017 )Tj 0.121 Tw -18.684 -1.218 Td [(\021\030\024\235\017\004\036\f\022\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\007\035\017\021\036\035\034\027\024 )0.5(\027\036\026\032\017\r\026\033\013\017\b )0.5(\030\026\027 \017)]TJ /Span<>> BDC ( )Tj EMC (\016\r, )Tj 0.14 Tw T* (\024\f\021\036\024\026\030\021\030\024\026\b, \022\024\027\021\031\030\027\ \t\b \007\036\235\024\030\n\026\006\017\016\b \n\016\020\022\017\b \021\022\ \026)Tj 0 Tw (-)Tj 0.144 Tw T* (\027\036\005 \035\017\006\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\035\026, \024\032\024\020\026\b, \007\036\235\036\022\021\026\b\ \023\036\030\017\235\036\030\017\004\036\f\022\017\b )Tj 0.094 Tw T* (\027\036\030\r\024\r, \f\021\030\017\022\021\031\030\036 \031\030\036\021\ \030\t, \030\026\f\f\036\016\027\027\024\n \f\022\035\036\030\024\036, \ \017\027)Tj 0 Tw (-)Tj 0.042 Tw T* (\235\026\030\022\021\036 \n\017\024\022\026\030\007\026, \017\027\f\031\035\ \034\021\026\b \030\026\035\017\004\027\024\020\024 \020\036\027\036\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\007\030. )Tj 0.211 Tw T* ([72,73]. \200)Tj /Span<>> BDC ( )Tj EMC [(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\004\036\f\022\024\ \005 )0.5(\023\030\026\022\021\017\022\036 \204\222\025-\240\221 )]TJ -0.02 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\f\023\036\b\024\n \023\030\017\n\036\027\016\033\021\f\016 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\035\031\004\036\r\t\b \016\r\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022)Tj 0 Tw (-)Tj 0.07 Tw T* (\021\024\r\026\020\017\027\026\035\034\027\t\b \f\r\017\013\026\b, \022\030\ \017\023\021\024\020\035\026\027\007\031\035\016\030\027\t\b \f\r\017\013\ \026\b, )Tj -0.001 Tw T* [(\f\035\024\032\027\t\b )0.5(\023\036\030\017\026\027\026\035\034\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\022\021\026\035\034\027\t\b \f\r\017\013\026\b )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\002\024)Tj 0 Tw (-)Tj T* (\035\036\027\017 \025\030\024\027\026 [75,76].)Tj 1.137 Tw T* [(\215\024 )0.5(\030\036\031\035\034\021\026\021\026\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\r\t\023\024\035\027\036\027\027\024\020\024 )]TJ 0.001 Tw T* (\221\036\030\033\001\022\024\r\024\005 \240.\230. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2019\) [75], \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \027\036)Tj 0 Tw (-)Tj 0.181 Tw T* (\023\024\f\030\036\007\f\021\r\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\b \030\036\031\035\034\021\026\021\024\ \r \035\036\004\036\027\017\016 )Tj 0.217 Tw T* (\023\024\f\021\035\031\004\036\r\t\b \023\024\r\030\036\032\007\036\027\017\ \005 \023\030\016\n\024\005 \022\017\001\022\017 \(\023\030\024\022\021\017\ \021, )Tj 0.278 Tw T* (\016\r\026, \030\036\022\021\024\r\026\020\017\027\026\035\034\027\t\005\ \f\r\017\013\) \n\036\021\024\007\024\n \n\017\022\030\024\017\027\255)Tj 0 Tw (-)Tj 0.024 Tw T* (\036\022\006\017\017 \204\222\025-\240\221 \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.024 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (33\), \023\024\035\027\026\016 \220\023\017\021\036\035\017\026\006\017\ \016 \027\026\002\035\033)Tj 0 Tw (-)Tj 0.064 Tw T* (\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (100% \f\035\031\004\026\036\r, \007\035\016 \007\024\f\021\017\032\036\027\ \017\016 \022\024\021\024\030\024\005 \023\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\021\030\036\002\024\r\026\035\024\f\034 \024\021 2 \007\024)Tj /Span<>> BDC ( )Tj EMC (5 \017\027\255\036\022\006\017\005, \f\030\024\022\017 \026\032\017\r\035\ \036\027\017\016 )Tj 0.14 Tw T* (\r\026\030\034\017\030\024\r\026\035\017 \024\021 6 \n\036\f\016\006\036\ \r \007\024)Tj /Span<>> BDC ( )Tj EMC (2 \035\036\021 \(\f\030\036\007\027\036\036 \r\030\036\n\016 )Tj 0.373 Tw T* [(\007\035\016 \026\032\017\r\035\036\027\017\016 )0.5(\023\024\f\021\035\031\004\036\r\024\005 \016\r\t )0.5(6 \n\036\f\016\006\036\r)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.083 Tw -21.11 -1.218 Td (77,5%, \007\035\016 \023\024\f\021\035\031\004\036\r\t\b \f\r\017\013\036\ \005 12 \n\036\f\016\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 63%\) )Tj 0.162 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \021\016\032\036\f\021\017 \026\ \002\024\035\036\r\026\027\017\016. \202\r\021\024\030\t \024\021)Tj 0 Tw (-)Tj 0.463 Tw T* [(\n\036\004\026\033\021, \004\021\024 \f\021\026\021\017\f\021\017\004\036\ \f\022\017 )0.5(\027\026\004\017\n\024\005 \022\024\030\030\036\035\016\006\017\017 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (162)Tj ET endstream endobj 358 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, \202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.006 Tw 10 0 0 10 42.5197 724.8299 Tm (\026\007\027\036\023\036\021\035\036\r\026\016 \030\036\022\021\024\023\ \036\022\f\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\036\030\026\006\017\016 \211\220\035\035\f\026, \030\036\022\ )Tj 0 Tw (-)Tj 0.166 Tw 0 -1.218 TD [(\021\024\023\036\022\f\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\036\022\006\017\036\005 )0.5(\021\024\035\f\021\024\005 \022\017\001\022\017, )0.5(\023\036\030\036\007\027\016\016 )0.5(\030\036)]TJ 0 Tw (-)Tj T* (\036\022\006\017\016 \023\030\016\n\024\005 \022\017\001\022\017\) [30]\ .)Tj 0.393 Tw T* (\003\026\032\017\r\035\036\027\017\036 \016\r\036\027\027\024\020\024 \007\ \036\235\036\022\021\026 \023\024\f\035\036 \b\017\030\031\030\020\017\004\ \036)Tj 0 Tw (-)Tj 0.077 Tw T* (\f\022\024\020\024 \035\036\004\036\027\017\016 \030\036\020\017\f\021\030\ \017\030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\n \002\024\035\034)Tj 0 Tw (-)Tj 0.234 Tw T* (\001\017\027\f\021\r\036 \f\035\031\004\026\036\r, \024\007\027\026\022\024\ \007\024\035\020\024\f\030\024\004\027\t\036 \030\036\031\035\034\021\026\ \021\t )Tj 0.128 Tw 0 -1.218 TD (\024\f\021\026\033\021\f\016 \027\036\016\f\027\t\n\017 [46]. \217\017\f\ \022 \030\036\006\017\007\017\r\026 \030\036\022\021\026\035\034\027\024\ )Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD (\020\024 \023\030\024\035\026\023\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\t\b \027\026\030\031\001\ \036\027\017\005 \021\024\035\f\021\024\005 )Tj 0 Tw T* (\022\017\001\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ \007\024\f\021\017\020\026\036\021 30% [45,46].)Tj 0.687 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \030\036\021\030\024\f\023\ \036\022\021\017\r\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.004 Tw T* (\200\024\005\027\024\r\026 \204.\202. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2015\) [47], \b\017\030\031\030\020\017\004\036\f\022\ \024\036 \035\036)Tj 0 Tw (-)Tj 0.044 Tw T* (\004\036\027\017\036 \(\030\036\022\021\024\f\026\022\030\024\023\036\022\ \f\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\023\036\021\035\036\r\026\016 \030\036\022\021\024\023\ \036\022)Tj 0 Tw (-)Tj 0.03 Tw 0 -1.218 TD (\f\017\016\) \030\036\022\021\026\035\034\027\024\020\024 \023\030\024\035\ \026\023\f\026 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\026\006\017\017 )Tj 0.103 Tw 0 -1.218 TD (\222\222\242\215\025 \r)Tj /Span<>> BDC ( )Tj EMC (73,9% \f\035\031\004\026\036\r \(\f\030\036\007\027\017\036 \f\030\024\022\ \017 \027\026\002\035\033\007\036\027\017\016 )Tj 0.122 Tw 0 -1.218 TD (20,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,7 \n\036\f\016\006\036\r\). \200)Tj /Span<>> BDC ( )Tj EMC [(\021\024\032\036 \r\030\036\n\016 Ihna)15(t)]TJ /Span<>> BDC ( )Tj EMC (P. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.33 Tw T* ([48] \024\023\031\002\035\017\022\024\r\026\035\017 \031\f\023\036\001\027\ \024 \017\035\036\004\036\027\027\t\005 \022\035\017\027\017\004\036)Tj 0 Tw (-)Tj 0.01 Tw T* [(\f\022\017\005 \f\035\031\004\026\005 )0.5(\222\222\242\215\025 \027\026)]TJ /Span<>> BDC ( )Tj EMC 9.352 0 Td (\235\024\027\036 \f\017\027\007\030\024\n\026 \024\002\f\021\030\031\022\ \021\017\r\027\024\005 )Tj 0.077 Tw -9.352 -1.218 Td (\007\036\235\036\022\026\006\017\017 \(\030\036\022\021\024\006\036\035\036\ , \220\027\021\036\030\024\006\036\035\036, \r\027\031\021\030\036\027\027\ \017\005 \030\036\022)Tj 0 Tw (-)Tj 0.316 Tw T* (\021\026\035\034\027\t\005 \023\030\024\035\026\023\f \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\017\b\024\f\017\020\n\026\). \215\024\035\024\032\017\021\036\ \035\034\027\t\005 )Tj 0.454 Tw T* (\220\235\235\036\022\021 \002\t\035 \007\024\f\021\017\020\027\031\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\030\017\n\036\027\036\027\017\ \016 )Tj 1.471 Tw T* [(\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017-\026\f\f\017\ \f\021\017\030\024\r\026\027\027\024\005 )0.7(\030\036\022\021\024\023\036\022\f\017\017 )]TJ 0.315 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\026\027\026\035\034\027\024\005 \220\027\007\024\f\022\ \024\023\017\004\036\f\022\024\005 \n\017\022\030\024\b\017\030\031\030\020\ \017\017, )Tj 0.177 Tw T* (\004\021\024 \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034 \022\024\n\002\017\027\017\ \030\024\r\026\027\027\t\b )Tj 0.071 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\b \n\036\021\024\007\024\r \ \035\036\004\036\027\017\016 \222\222\242\215\025, \r\022\035\033\004\026\ \016 \n\026)Tj 0 Tw (-)Tj 0.244 Tw T* [(\035\024\017\027\r\026\017\r\027\t\036 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\036 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026, )0.6(\024\002\036\f)]TJ /Span<>> BDC (-)Tj EMC 0.066 Tw T* (\023\036\004\017\r\026\033\013\017\036 \022\026\022 \220\235\235\036\022\ \021\017\r\027\031\033 \022\024\030\030\036\022\006\017\033 \f\017\027\007\ \030\024\n\026 )Tj 0.051 Tw T* (\024\002\f\021\030\031\022\021\017\r\027\024\005 \007\036\235\036\022\026\ \006\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\235\024\030\021\027\t\005 \b\017\030\031\030)Tj 0 Tw (-)Tj -0.046 Tw T* (\020\017\004\036\f\022\017\005 \007\024\f\021\031\023 \007\035\016 \030\026\ \007\017\022\026\035\034\027\024\005 \030\036\036\022\006\017\017 \016\ \r\t \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017.)Tj 0.212 Tw T* (\215\024 \007\026\027\027\t\n \n\036\021\026\026\027\026\035\017\026 \035\ \017\021\036\030\026\021\031\030\t \007\035\016 \024\023\030\036\007\036\ \035\036)Tj 0 Tw (-)Tj 0.13 Tw T* (\027\017\016 \220\235\235\036\022\021\017\r\027\024\f\021\017 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \ \222\222\242\215\025, )Tj 0.027 Tw T* (\r\t\023\024\035\027\036\027\027\024\020\024 Gaj F. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2024 \020.)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.027 Tw 16.225 0 Td ([46], \220\027\007\024\f\022\024)Tj 0 Tw (-)Tj 0.309 Tw -16.225 -1.218 Td (\023\017\004\036\f\022\017\005 \(\026\030\020\024\027\027\024-\023\035\026\ \n\036\027\027\026\016 \022\024\026\020\031\035\016\006\017\016)Tj /Span<>> BDC ( )Tj EMC 19.139 0 Td (+)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-)Tj 0.605 Tw -19.139 -1.218 Td (\021\036\030\026\023\017\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \030\036\022\021\026\035\034\027\024\020\ \024 \023\030\024\035\026\023\f\026\) )Tj 0.297 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\017\005 )0.6(\(\023\030\017 )0.5(\r\027\031\021\030\036\027\027\036\005 )0.6(\030\036\022\021\026\035\034\027\024\005 )0.5(\017\027)]TJ 0 Tw (-)Tj 0.243 Tw -1.048 -1.218 Td (\r\026\020\017\027\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\022\021\024\023\036\022\f\017\016 \017\035\017 \023\036\030\ \036\007\027\016\016 \030\036\036\022\006\017\016 )Tj 0.352 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\024\n \r\t\023\026\007\036\027\017\017 \023\030\ \016\n\024\005 )Tj 0.153 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC [(\227 )0.5(\030\036\036\022\006\017\016 \f\035\017\017\f\021\024\005 )0.5(\024\002\024\035\024\004\022\017 )0.5(\017\035\017 \023\030\024\022\021)]TJ /Span<>> BDC (-)Tj EMC 0.349 Tw T* [(\220\022\021\024\n\017\016\) )0.5(\n\036\021\024\007\t )0.6(\035\036\004\036\027\017\016 )0.5(\002\t\035\017 )0.6(\027\026\017\002\024\035\036\036 )0.5(\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.227 Tw T* (\021\017\r\027\t\n\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \n\036\021\026\026\027\026\035\017\ \026 \024\023\030\036\007\036\035\036\027\024, )Tj 0.12 Tw T* (\004\021\024 \026\032\017\r\035\036\027\017\036 \016\r\t \027\026\002\035\ \033\007\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (74,2% \017)Tj /Span<>> BDC ( )Tj EMC (70,5% )Tj 0.36 Tw T* (\f\035\031\004\026\036\r, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\ , \004\021\024 \023\030\036\r\t\001\026\035\024 \220\235\235\036\022\021\ \t )Tj 0.091 Tw T* (\022\024\027\f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\ \017 \(\217\217 0,26, 95% CI 0,15\2260,37; )Tj 0 Tw T* (I)Tj 5.83 0 0 5.83 46.2596 204.5058 Tm (2)Tj 0.113 Tw /Span<>> BDC 10 0 0 10 49.1746 201.1758 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (88%, )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.113 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \017)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-\021\036\030\026\023\017\017 \(PP 0,39, 95% CI )Tj 0 Tw -0.665 -1.218 Td (0,27\2260,52; I)Tj 5.83 0 0 5.83 90.9593 192.3278 Tm ( 2)Tj /Span<>> BDC 10 0 0 10 95.2326 188.9978 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (57%, )Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\))Tj /T1_2 1 Tf (.)Tj /T1_1 1 Tf 0.004 Tc 0.208 Tw -5.271 -1.218 Td [(\217\026\027\024\024\002\030\026\017\036 )0.5(\023\024\007\b\024\007\024\r )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 11.582 0 Td [(\035\036\004\036\027\017\033 )0.5(\222\222\242\215\025 \024\021\030\026\032\026)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.269 Tw -11.582 -1.218 Td [(\036\021 \027\026\035\017\004\017\036 \022\026\022 \002\024\035\034\001\024\ \020\024 \022\024\035\017\004\036\f\021\r\026 \027\036\030\036\001\036\027\ \027\t\b)4.1( )]TJ 0.358 Tw T* (\r\024\023\030\024\f\024\r, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\031\026\035\034\027\024\f\021\034 \007\026\035\034\027\036\005\ \001\017\b \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.331 Tw T* (\007\024\r\026\027\017\005, \r\022\035\033\004\026\016 \023\030\017\n\036\ \027\036\027\017\036 \022\035\036\021\024\004\027\t\b \002\017\024\021\036\ \b)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.254 Tw T* (\027\024\035\024\020\017\005, \022\024\021\024\030\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\024\r\030\036\n\036\027\027\024\n \220\021\026\023\036 \030\026\r\017\ \021\017\016)4.1( )]TJ 0.327 Tw T* (\030\036\020\036\027\036\030\026\021\017\r\027\024\005 \n\036\007\017\006\ \017\027\t \017\n\036\033\021 \r\t\f\024\022\017\005 \023\024\021\036\027\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.049 Tw T* (\006\017\026\035 \023\030\017\n\036\027\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\036\021\024\n \r\024\n\024\032\027\024\f\021\036\005 \f\021\r\024\ \035\024\r\t\b)4( )]TJ 0.033 Tw T* [(\022\035\036\021\024\022 )0.5(\(\222\025\) )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.836 0 Td [(\r\024\f\f\021\026\027\024\r\035\036\027\017\017 \023\024\r\030\036\032\007\ \036\027\027\t\b )0.5(\021\022\026\027\036\005)4( )]TJ 0 Tw -5.836 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC ([49].)Tj ET 0 0 0 1 K 0.5 w q 1 0 0 1 274.9606 723.83 cm 0 0 m 221.102 0 l S Q q 1 0 0 1 274.9606 711.652 cm 0 0 m 27.64 0 l S Q BT /T1_3 1 Tf 0 Tc -0.029 Tw 10 0 0 10 274.9606 724.8299 Tm [(\200\r\006\217\212\r\220\003\t\013 \220\f\r\003\002\201\b\013\216 )0.5(\206\t\002\003\r\216\b\002\f\002\n\t\005 )]TJ /Span<>> BDC ( )Tj EMC (\f\r\201\r\b\t\t )Tj 0 Tw T* (\255\255\223\200\021)Tj /T1_1 1 Tf 0.621 Tw T* (\222\025 \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\002\024\005\ \027\036\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\ \036 )Tj 0.25 Tw T* (\022\035\036\021\022\017, \030\026\f\023\024\035\026\020\026\033\013\017\ \036\f\016 \023\030\026\022\021\017\004\036\f\022\017 \r\024 \r\f\036\b \ \024\030)Tj 0 Tw (-)Tj 0.101 Tw T* (\020\026\027\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \004\036\035\024\r\036\022\026 [50,51]. \025)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\n\031 \r\030\036)Tj 0 Tw (-)Tj 0.334 Tw T* (\n\036\027\017 \024\023\017\f\026\027\t \n\036\036\027\b\017\n\026\035\034\ \027\t\036, \027\036\005\030\026\035\034\027\t\036, \n\017\024)Tj /Span<>> BDC (-)Tj EMC 0.351 Tw 0 -1.218 TD (\020\036\027\027\t\036, \023\026\027\022\030\036\026\021\017\004\036\f\022\ \017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 \021\017\023\t \222\025 [52].)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.21 Tw 0 -1.218 TD (\206\035\026\r\027\t\n\017 \002\017\024\035\024\020\017\004\036\f\022\017\ \n\017 \f\r\024\005\f\021\r\026\n\017 \222\025 \016\r\035\016\036\021\f\016\ )Tj 0.502 Tw T* (\023\030\024\016\r\035\036\027\017\036 \001\017\030\024\022\024\020\024 \ \007\017\235\235\036\030\036\027\006\017\030\024\r\024\004\027\024\020\024\ \023\024)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\036\027\006\017\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \f\r\024\036\005 \022\024\n\023\036\021\036\ \027\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002)Tj 0 Tw (-)Tj 0.25 Tw T* (\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\024\002\027\024\r\035\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n \220\021\024\020\024 \023\024)Tj 0 Tw (-)Tj 0.569 Tw T* [(\021\036\027\006\017\026\035\026 )0.6([50,53,54]. )0.5(\205\026\022\021\024\030\026\n\017, )0.6(\024\023\030\036\007\036\035\016\033\013\017\n\017 )]TJ 0.028 Tw 0 -1.218 TD (\031\027\017\022\026\035\034\027\024\f\021\034 \222\025, \016\r\035\016\033\ \021\f\016: \017\002\t\021\024\022 \n\217\203\025 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 )Tj 0.179 Tw 0 -1.218 TD (\021\036\035\024\n\036\030\026\027\024\005 \026\022\021\017\r\027\024\f\ \021\017, \021\024 \036\f\021\034 \022\024\027\006\t \017\b \b\030\024\n\ \024)Tj 0 Tw (-)Tj 0.038 Tw 0 -1.218 TD (\f\024\n \027\026\007\f\021\030\026\017\r\026\033\021\f\016, \220\021\017\ \022\035\036\021\022\017 \f\023\024\f\024\002\027\t \023\030\024\b\024\007\ \017\021\034 )Tj 0.445 Tw T* (\023\024\021\036\027\006\017\026\035\034\027\024 \002\036\f\022\024\027\036\ \004\027\024\036 \022\024\035\017\004\036\f\021\r\024 \022\035\036\021\024\ \004\027\t\b )Tj 0.16 Tw T* (\007\036\035\036\027\017\005, \024\027\017 \002\036\f\f\n\036\030\021\027\ \t [50,55]. \222\025 \n\024\032\027\024 \030\026\007\036)Tj 0 Tw (-)Tj 0.151 Tw T* [(\035\017\021\034 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\030\017 )0.5(\024\f\027\024\r\027\t\036 )0.5(\020\030\031\023\023\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\026\r\017\f\017\n\024\f\021\017 )0.5(\024\021 \017\f)]TJ 0 Tw (-)Tj 0.266 Tw T* (\021\024\004\027\017\022\026 \017\b \023\024\035\031\004\036\027\017\016\ : \220\n\002\030\017\024\027\026\035\034\027\t\036, \235\036\021\026\035\ \034\027\t\036 )Tj 0.394 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\027\026\021\026\035\034\027\t\036 \(\222\025 \r\030\024\f\ \035\024\020\024 \024\030\020\026\027\017\n\026\))Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 20.074 0 Td ([51].)Tj /T1_2 1 Tf ( )Tj /T1_1 1 Tf 0.076 Tw -20.074 -1.218 Td [(\210\021\022\030\t\021\017\036 \020\036\n\024\023\024\220\021\017\004\036\ \f\022\017\b )0.5(\222\025 \(\n\031\035\034\021\017\023\024\021\036\027\021\027\t\036 )0.5(\n\036)]TJ 0 Tw (-)Tj 0.246 Tw T* [(\036\027\b\017\n\026\035\034\027\t\036 )0.6(\f\021\030\024\n\026\035\034\027\t\036 )0.6(\022\035\036\021\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 16.422 0 Td [(\022\024\f\021\027\024\n )0.5(\n\024)]TJ 0 Tw (-)Tj 0.155 Tw -16.422 -1.218 Td (\020\036)Tj /Span<>> BDC ( )Tj EMC (\227 \204\222\025-\025\204\) \016\r\035\016\036\021\f\016 \027\026\004\026\ \035\024\n \017\f\021\024\030\017\017 \017\031\004\036\027\017\016 )Tj 0.14 Tw T* (\030\036\020\017\024\027\026\030\027\t\b \222\025 \r\030\024\f\035\024\020\ \024 \024\030\020\026\027\017\n\026 [50]. \204\222\025-\025\204 )Tj 0.225 Tw T* (\r\023\036\030\r\t\036 \002\t\035\017 \017\007\036\027\021\017\235\017\006\ \017\030\024\r\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\b\026\030\026\022\021\036\030\017\024)Tj 0 Tw (-)Tj 0.067 Tw T* (\r\026\027\t \030\024\f\f\017\005\f\022\017\n \031\004\201\027\t\n \205\030\ \017\007\036\027\001\021\036\005\027\024\n)Tj /Span<>> BDC ( )Tj EMC (\202.\242. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.281 Tw T* (\026\r\021. [56]. \200\t\007\036\035\036\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\021\027\024\020\024 \n\024\020\026 \204\222\025-\025\204 )Tj 0.297 Tw T* [(\023\030\024\035\017\235\036\030\017\030\031\033\021 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.5(\007\017\f\022\030\036\021\027\t\b \026\007)]TJ 0 Tw (-)Tj 0.512 Tw T* (\020\036\017\r\027\t\b \022\024\035\024\027\017\005 \235\017\002\030\024\ \002\035\026\f\021\024\023\024\007\024\002\027\t\b \022\035\036\021\024\022\ . )Tj 0.204 Tw T* [(\025\026\032\007\026\016 )0.5(\022\024\035\024\027\017\016 )0.6(\024\002\030\026\031\036\021\f\016 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 13.782 0 Td [(\f\004\201\021 )0.5(\023\030\024\035\017\235\036\030\026\006\017\017 )]TJ 0.115 Tw -13.782 -1.218 Td [(\036\007\017\027\017\004\027\024\005 )0.6(\022\035\036\021\022\017-\023\030\036\007\001\036\f\021\r\036\027\027\017\ \006\t. )0.6(\025\024\035\024\027\017\017 )0.5(\204\222\025-)]TJ 0.256 Tw T* (\025\204 \024\007\027\024\r\030\036\n\036\027\027\024 \220\022\f\023\030\ \036\f\f\017\030\031\033\021 \021\030\026\027\f\022\030\017\023\021\t \007\ \035\016 )Tj 0.113 Tw T* (\030\026\035\017\004\027\t\b \035\017\027\017\005 \n\036\036\027\b\017\ \n\026\035\034\027\t\b \022\035\036\021\024\022, \n\217\203\025 \220\027\ )Tj 0 Tw (-)Tj -0.046 Tw T* [(\007\024\021\036\035\017\026\035\034\027\024\005, )0.6(\220\023\017\021\036\035\017\026\035\034\027\024\005, )0.5(\027\036\005\030\026\035\034\027\024\005 )0.6(\022\035\036\021\024\004\027\t\b )]TJ 0.204 Tw T* (\035\017\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \030\026\035\017\004\027\t\036 \002\017\024\n\024\035\ \036\022\031\035\t, \031\004\026\f\021\r\031\033)Tj 0 Tw (-)Tj 0.168 Tw T* (\013\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\017 \030\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\036 \027\036\005\030\024\021\030\024\235\027\ \t\036 )Tj 0.257 Tw T* (\235\026\022\021\024\030\t, \004\021\024 \024\023\030\036\007\036\035\016\ \036\021, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \002\024\035\034\001\017\027\f\021\r\026 )Tj 0.109 Tw T* [(\017\f\f\035\036\007\024\r\026\021\036\035\036\005, )0.6(\n\031\035\034\021\017\023\024\021\036\027\021\027\024\f\021\034 )0.5(\204\222\025-\025\204 )0.5([57,58].)]TJ /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf -0.044 Tw T* (\204\222\025-\025\204 \220\022\f\023\030\036\f\f\017\030\031\033\021 \030\ \026\035\017\004\027\t\036 \030\036\006\036\023\021\024\030\t \007\035\016\ \030\024)Tj 0 Tw (-)Tj 0.048 Tw T* (\f\021\024\r\t\b \235\026\022\021\024\030\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\006\017\021\024\022\017\027\024\r, \004\021\024 \007\026\201\021 \r\024\ \n\024\032\027\024\f\021\034 )Tj 0.393 Tw T* [(\007\035\016 )0.5(\023\024\035\031\004\036\027\017\016 )0.6(\017\n\017 )0.5(\017\027\007\031\022\021\017\r\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.426 0 Td (\030\036\020\031\035\016\021\024\030\027\t\b )Tj 0.112 Tw -16.426 -1.218 Td (\f\017\020\027\026\035\024\r \024\021 \024\022\030\031\032\026\033\013\017\ \b \022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \026\031\021\024\022\030\017\027\027\024\n\031 )Tj 0.057 Tw T* [(\n\036\b\026\027\017\n\031. )0.6(\025\030\024\n\036 )0.5(\021\024\020\024, )0.5(\204\222\025-\025\204 )0.5(\f\017\027\021\036\017\030\031\033\021 )0.6(\022\024\n\023\024)]TJ 0 Tw (-)Tj 0.173 Tw T* (\027\036\027\021\t \r\027\036\022\035\036\021\024\004\027\024\020\024 \n\ \026\021\030\017\022\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\017\r\026\033\021 \036\020\024 )Tj 0.038 Tw T* (\f\021\030\031\022\021\031\030\017\026\006\017\033. \212\024\022\026\026\ \027\024 \023\035\026\f\021\017\004\027\024\036 \023\024\r\036\007\036\027\ \017\036 \222\025 )Tj 0.143 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\017\n\t\b \023\030\024\006\036\f\f\026\b \220\023\017\ \021\036\035\017\026\035\034\027\024-\n\036\036\027\b\017\n\026\035\034\ )Tj 0 Tw (-)Tj -0.034 Tw T* (\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\036\027\b\017\n\026\035\034\027\024-\220\023\017\021\036\035\017\ \026\035\034\027\024\005 \021\030\026\027\f\235\024\030\n\026\006\017\017\ )Tj 0.123 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \023\026\021\024\035\024\020\017\004\036\ \f\022\017\b \023\030\024\006\036\f\f\026\b \r\024 \r\030\024\f)Tj 0 Tw (-)Tj 0.155 Tw T* (\035\024\n \024\030\020\026\027\017\n\036, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\024\r\035\036\004\036\027\017\036 \220\021\024\020\ \024 \023\030\024\006\036\f\f\026 )Tj -0.036 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\036\027\036\030\026\006\017\033 \024\030\020\026\027\024\r \ \017)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 \023\024\f\021)Tj 0 Tw (-)Tj T* (\027\026\021\026\035\034\027\024\020\024 \024\027\021\024\020\036\027\036\ \026 [59,60].)Tj 0.375 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\034\027\t\b \017\f\f\035\036\007\024\r\ \026\027\017\005 \026\035\035\024\021\030\026\027)Tj 0 Tw (-)Tj -0.084 Tw T* [(\f\023\035\026\027\021\026\006\017\017 )0.6(\022\035\036\021\024\004\027\024\020\024 )0.5(\n\026\021\036\030\017\026\035\026 )0.6(\016\r\035\016\036\021\f\016 )0.5(\027\024\r\t\005 )0.6(\n\036)]TJ 0 Tw (-)Tj 0.085 Tw T* [(\021\024\007 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016 \f\036\n\036\005\027\024\020\024 \026\007\036\ \027\024\n\026\021\024\026 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 504.6646 56.0378 Tm (161)Tj ET endstream endobj 54 0 obj 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\f\r\016\017 \(\207\210\222-\021\036\030\026\023\017\016\) \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\035\017)Tj 0 Tw (-)Tj 0.172 Tw T* (\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\f\031\022\030\026\035\034\235\026\021\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\017\n\036\027\036\027\017\036 \004\036\035\ \024\r\036\004\036)Tj 0 Tw (-)Tj -0.006 Tw T* (\f\022\024\020\024 \235\017\002\030\017\027\026 \023\024\022\026\026\035\ \017 \031\f\023\036\001\027\024\f\021\034 \007\026\027\027\t\b \n\036\021\ \024\007\024\r )Tj 0.213 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\032\017\r\035\036\027\017\016 \016\r, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \r)Tj /Span<>> BDC ( )Tj EMC (57% \f\035\031\004\026\036\r )Tj 0.35 Tw T* [(\(\007\017\026\023\026\024\027 )0.6(41\22674%\). )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 11.597 0 Td [(\026\027\026\035\017\036 )0.6(\023\024\007\020\030\031\023\023 )0.5(\030\036\020\017)]TJ 0 Tw (-)Tj 0.055 Tw -11.597 -1.218 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/Span<>> BDC ( )Tj EMC 6.355 0 Td [(\030\036\022\021\024\026\027\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.661 0 Td [(\006\036\035\034\033 )0.6(\022\031\023\017)]TJ 0 Tw (-)Tj 0.15 Tw -17.017 -1.218 Td (\030\024\r\026\027\017\016 \030\036\022\021\026\035\034\027\024\020\024 \ \023\030\024\035\026\023\f\026, \031\r\036\035\017\004\036\027\017\016 \022\ \030\024\r\024\f)Tj 0 Tw (-)Tj 0.266 Tw T* (\027\026\002\032\036\027\017\016 \f\035\017\017\f\021\024\005 \024\002\024\ \035\024\004\022\017 \007\017\f\021\026\035\034\027\024\020\024 \024\021\ \007\036\035\026 )Tj -0.008 Tw T* [(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.009 0 Td [(\031\035\031\004\001\036\027\017\016 )0.6(\r\036\020\036\021\026\021\017\r\027\024\005 )0.5(\b\024\035\017\027\036\030\020\017)]TJ 0 Tw (-)Tj 0.061 Tw -7.009 -1.218 Td (\004\036\f\022\024\005 \017\027\027\036\030\r\026\006\017\017 \022\017\001\ 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\016\r\t\))Tj /T1_1 1 Tf (.)Tj /T1_0 1 Tf 0.046 Tw T* [(\200 )0.6(\021\024\032\036 )0.6(\r\030\036\n\016 )0.5(Gour)-36.9(iou )0.5(\222. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.193 0 Td [(\f\024\026\r\021. )0.6([34])]TJ /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.046 Tw 4.847 0 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.752 0 Td [(\f\r\024\036\n )0.6(\f\017\f\021\036)]TJ 0 Tw (-)Tj 0.365 Tw -16.792 -1.218 Td (\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036 \024\021\n\036\021\ \017\035\017, \004\021\024 \022\024\027\f\036\030\r\026\021\017\r\027\026\ \016 )Tj 0.009 Tw T* (\021\036\030\026\023\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-\021\036\030\026\023\017\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.229 Tw T* (\006\017\036\027\021\024\r \002\036 \030\036\022\021\026\035\034\027\024\ \020\024 \023\030\024\035\026\023\f\026 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\030\036\022\021\026\035\034\027\024\036 )Tj 0 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\036 [34].)Tj 0.173 Tw T* (\204\036\f\021\027\026\016 \021\036\030\026\023\017\016 \n\036\021\024\007\ \024\n \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \r\r\ \036\007\036)Tj 0 Tw (-)Tj 0.222 Tw T* [(\027\017\016 \023\030\036\023\026\030\026\021\026 \253P)20(ur)-33(aS)15(t)15(a)15(t\273 \(\2533D-Ma)15.1(tr)-37(ix Eur)-31.9(ope SA)35(S\273, )]TJ 0.164 Tw T* (\205\030\026\027\006\017\016)Tj /Span<>> BDC ( )Tj EMC 4.004 0 Td [(\227 )0.5(\r\027\036\022\035\036\021\024\004\027\026\016 )0.6(\n\026\021\030\017\006\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.587 0 Td (\026\n\017\027\024\022\017\f\035\024\021, )Tj ET q 1 0 0 1 303.3071 175.8199 cm 0 0 m 159.297 0 l S Q BT /T1_0 1 Tf 0.34 Tw 10 0 0 10 303.3071 724.8299 Tm (\f\026\n\024\024\030\020\026\027\017\031\033\013\026\016\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\023\021\017\007 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\007\020\036\017\r\027\024)Tj 0 Tw (-)Tj 0.209 Tw T* (\020\024 \002\026\030\034\036\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\036\f\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\031 \022\030\024\r\024\021\036\004\036\027\017\016\) )Tj 0.101 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\016 \016\r\036\027\027\024\020\024 \007\036\235\036\022\021\ \026 \002\t\035\026 \031\f\023\036\001\027\024 \023\030\017\n\036\027\036\ \027\026 )Tj 0.027 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \024\023\031\002\035\017\022\024\r\026\027\027\024\n \ \027\026\002\035\033\007\036\027\017\017 \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.027 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\). \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj -0.048 Tw T* (\027\024\n \022\035\017\027\017\004\036\f\022\024\n \f\035\031\004\026\036\ \002\t\035\024 \026\030\036\020\017\f\021\030\017\030\024\r\026\027\024\ \023\024\035)Tj 0 Tw (-)Tj T* (\027\024\036 \026\032\017\r\035\036\027\017\036 \016\r\t [38].)Tj 0.018 Tc -0.016 Tw 0 -1.218 TD (\215\030\017\n\036\027\036\027\017\036 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\005 \026\023\023\035\017\022\026\006\017\017 \027\026\ )Tj /Span<>> BDC ( )Tj EMC [(\222\242\215\025)18( )]TJ 0.37 Tw 0 -1.218 TD (\235\017\002\030\017\027\024\r\024\020\024 \022\035\036\016 \r)Tj /Span<>> BDC ( )Tj EMC 10.064 0 Td [(100% )0.5(\f\035\031\004\026\036\r, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n)18( )]TJ 0.174 Tw -10.064 -1.218 Td [(Eder)-29.9(le)]TJ /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1992\) [39], \023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\024\005)18( )]TJ 0.53 Tw T* (\220\023\017\021\036\035\017\026\006\017\017 \016\r\036\027\027\024\020\ \024 \007\036\235\036\022\021\026, \024\007\027\026\022\024 \007\026\027\ )Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.377 Tw T* (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \024\020\030\026\ \027\017\004\036\027\024 \027\036\002\024\035\034\001\024\005 \f\036\030\ \017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.215 Tw T* (\036\005 \f\035\031\004\026\036\r \017)Tj /Span<>> BDC ( )Tj EMC [(\024\021\f\031\021\f\021\r\017\036\n \007\026\027\027\t\b \024\002 \024\021\ \007\026\035\201\027\027\t\b)18( )]TJ -0.018 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\026\b.)Tj 0 Tc 0.79 Tw 0 -1.218 TD (\233\235\235\036\022\021\017\r\027\024\f\021\034 \023\030\017\n\036\027\036\ \027\017\016 \026\030\020\024\027\027\024-\023\035\026\n\036\027\027\024\ \005 )Tj 0.175 Tw 0 -1.218 TD (\022\024\026\020\031\035\016\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\036\022\f\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\024\005 \022\024\027\f\036\030\r\ \026)Tj 0 Tw (-)Tj 0.238 Tw T* (\021\017\r\027\024\005 \021\036\030\026\023\017\036\005 \(\007\017\036\021\ \026)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-\021\036\030\026\023\017\016\) \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\002\035\017)Tj 0 Tw (-)Tj 0.191 Tw T* (\022\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (2017 \017)Tj /Span<>> BDC ( )Tj EMC (2024 \020\020. \023\030\024\f\023\036\022\021\017\r\027\t\b \030\026\027\ \007\024)Tj 0 Tw (-)Tj 0.427 Tw T* (\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\016\b \022\024\035\036\002\035\036\021\f\016 \024\021 66,7 )Tj 0.649 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC [(76,3%, \020\036\n\024\f\021\026\021\017\004\036\f\022\017\005 )0.5(\220\235\235\036\022\021 \007\024\f\021\017\020\026\036\021\f\016 )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (100% \f\035\031\004\026\036\r)Tj /Span<>> BDC ( )Tj EMC ([40,41].)Tj -0.026 Tw T* (\233\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \235\024\021\024\ \002\017\024\n\024\007\031\035\016\006\017\024\027\027\026\016 \(\035\026\ \036\030\027\026\016\) )Tj 0.008 Tw T* (\021\036\030\026\023\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \024\023\031\002\035\017\022\024\r\026\027\027\024\005\ \f\036\030\017\017 \022\035\017\027\017\004\036\f\022\017\b )Tj 0.277 Tw T* (\f\035\031\004\026\036\r \002\t\035\026 \220\235\235\036\022\021\017\r\027\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r 93% \027\026\002\035\033\007\026\035\026\f\034 )Tj 0.007 Tw T* (\023\024\035\027\026\016 \220\023\017\021\036\035\017\026\006\017\016 \016\ \r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \002\036 \r\t\023\026\007\036\027\017\ \016 )Tj T* (\023\030\016\n\024\005 \022\017\001\022\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \007\026\035\034\027\036\005\001\036\020\024 \027\026\ \002\035\033\007\036\027\017\016, )Tj 0.273 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026 \016\r \027\036 \030\036\020\017\f\021\030\ \017\030\024\r\026\035\024\f\034, )Tj -0.026 Tw T* [(\024\007\027\026\022\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 )0.6(\002\t\035\024 )0.5(\024\020\030\026\027\017\004\036\027\024 )0.6(\n\026\035\024\005 )0.5(\r\t\002\024\030)]TJ 0 Tw (-)Tj T* (\022\024\005 \023\026\006\017\036\027\021\024\r [42].)Tj 0.01 Tc -0.007 Tw T* (\215\024 \007\026\027\027\t\n Jha A.K. \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \(2021\) [43], Ha)15(y)22(asak)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(J.)10( )]TJ 0.285 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2022\) [44], \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\036 \024\023\036\030\026\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.161 Tw T* [(\027\024\036 )0.5(\035\036\004\036\027\017\036 )0.5(\023\030\017\n\036\027\016\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.526 0 Td [(\023\024\035\017\023\024\r\017\007\027\024\005 )0.5(\235\024\030)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.61 Tw -13.526 -1.218 Td (\n\036 \222\222\242\215\025 \f)Tj /Span<>> BDC ( )Tj EMC [(\n\026\027\017\235\036\f\021\017\030\031\033\013\017\n \022\030\024\r\024\ \021\036\004\036\027\017\036\n)9.9( )]TJ 0.33 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\031\007\026\004\027\024\005 \022\024\027\f\036\030\r\026\021\017\ \r\027\024\005 \021\036\030\026\023\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.107 Tw T* (\027\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \n\031\022\024\220\022\021\024\n\017\017 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.01 Tc 0.107 Tw /Span<>> BDC 14.543 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\) \017\035\017 \007\017\f\f\036\022)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.185 Tw -14.543 -1.218 Td (\006\017\017 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.01 Tc 0.185 Tw /Span<>> BDC 2.892 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4\) \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036)Tj /T1_1 1 Tf 0 Tc 0 Tw (.)Tj /T1_0 1 Tf 0.01 Tc 0.185 Tw 12.128 0 Td ( \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n)10( )]TJ 0.265 Tw -15.02 -1.218 Td [(\007\026\027\027\t\b \027\026\002\035\033\007\036\027\017\005 \024\002\026\ \220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \n\036\021\024\007\ \026)10( )]TJ 0.262 Tw T* (\002\t\035\017 \220\235\235\036\022\021\017\r\027\t\n\017 \r)Tj /Span<>> BDC ( )Tj EMC [(100% \f\035\031\004\026\036\r \002\036 \030\026\027\027\017\b)10( )]TJ 0.705 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\021\007\026\035\201\027\027\t\b \023\024\f\035\036\024\023\036\030\026\ \006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005)10( )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\r)Tj /Span<>> BDC ( )Tj EMC ([43,44].)Tj 0 Tc 0.016 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \021\026\022\017\036 \220\027\ \007\024\f\022\024\023\017\004\036\f\022\017\036 \n\036\021\024\007\t \035\ \036\004\036)Tj 0 Tw (-)Tj 0.16 Tw T* (\027\017\016 \222\242\215\025, \022\026\022 \023\030\017\n\036\027\036\027\ \017\036 \235\017\002\030\017\027\024\r\024\020\024 \022\035\036\016, \023\ \030\036)Tj 0 Tw (-)Tj 0.035 Tw T* [(\023\026\030\026\021\026 \253P)20(ur)-33(aS)15(t)15.1(a)14.9(t\273 \017)]TJ /Span<>> BDC ( )Tj EMC (\026\030\020\024\027\027\024-\023\035\026\n\036\027\027\024\005 \022\024\ \026\020\031\035\016\006\017\017 )Tj 0.173 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\017 \024\007\017\027\026\022\024\r\ \024\005 \220\235\235\036\022\021\017\r\027\024\f\021\034\033 \023\030\017\ \n\036)Tj 0 Tw (-)Tj -0.018 Tw T* (\027\016\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \235\024\030\n\026\b \222\242\215\025 \(\023\024\035\017\023\024\ \r\017\007\027\026\016, \016\r\036\027)Tj 0 Tw (-)Tj T* (\027\026\016, \f\n\036\001\026\027\027\026\016\).)Tj T* (\216\017\030\031\030\020\017\004\036\f\022\017\036 \n\036\021\024\007\t \ \035\036\004\036\027\017\016 \222\222\242\215\025)Tj 0.195 Tw T* (\216\017\030\031\030\020\017\004\036\f\022\017\036 \n\036\021\024\007\t \ \035\036\004\036\027\017\016 \222\222\242\215\025 \027\026\023\030\026\r\ \035\036\027\t, )Tj 0.14 Tw T* [(\022\026\022 )0.5(\023\030\026\r\017\035\024, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.094 0 Td [(\022\031\023\017\030\024\r\026\027\017\036 )0.6(\030\036\022\021\026\035\034\027\024\020\024 )0.5(\023\030\024\035\026\023\f\026 )]TJ 0.143 Tw -7.094 -1.218 Td (\030\026\035\017\004\027\024\005 \f\021\036\023\036\027\017 \021\016\032\ \036\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\016\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.291 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.6(\r\f\036\b )0.5(\r\t\001\036\023\036\030\036\004\017\f\035\036\027\027\t\b )0.6(\n\036\021\024\007\024\r. )]TJ 0.263 Tw T* (\222\030\036\007\017 \b\017\030\031\030\020\017\004\036\f\022\017\b \024\ \023\036\030\026\006\017\005 \r\t\007\036\035\016\033\021 \023\030\024\n\ \036\032)Tj 0 Tw (-)Tj 0.22 Tw T* [(\027\024\f\021\027\t\036 )0.6(\(\024\023\036\030\026\006\017\016 )0.5(\212\036\035\024\030\n\026, )0.5(\202\035\034\021\n\026\005\036\030\026\) )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 19.465 0 Td (\021\030\026\027\f)Tj 0 Tw (-)Tj 0.271 Tw -19.465 -1.218 Td (\026\002\007\024\n\017\027\026\035\034\027\t\036 \(\001\024\r\027\026\016\ \030\036\022\021\024\023\036\022\f\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\036\030\026\006\017\016 )Tj 0.551 Tw T* (\003\036\030\036\027\017\027\026\226\025\033\n\n\036\035\016, \030\036\022\ \021\024 \(\022\024\035\034\023\024\) \f\026\022\030\024\023\036\022\f\017\ \016, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (160)Tj ET endstream endobj 522 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, \202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.287 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\030\024\022\021\017\021\024\n, \022\035\024\026\022\024\020\036\027\ \027\t\n \023\024\035\017\023\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\b )Tj 0 Tw 0 -1.218 TD (\f\035\031\004\026\016\b \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\030\006\017\027\024\n\024\005 [24,25,26].)Tj /T1_2 1 Tf 0.184 Tw 0 -2.436 TD [(\222\f\001\003\006\004\213\210\220\002\004\235 )0.5(\220\004\006\003\t\b\004)]TJ /T1_1 1 Tf [( \222\242\215\025 \023\030\036\007\f\021\026\r\035\036\027\026 )0.5(\031\021\024\035)]TJ 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\013\036\027\027\024\005 \f\021\036\027\022\024\005 \022\017\001\022\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\026\r\027\024\n\036\030\027\t\n \030\026\f\023\030\036\007\036\ )Tj 0 Tw (-)Tj 0.257 Tw T* [(\035\036\027\017\036\n )0.6(\f\035\024\201\r. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.747 0 Td [(\027\026\035\017\004\017\017 )0.6(\030\036\022\021\026\035\034\027\024\020\024 )0.5(\023\030\024\035\026\023\f\026 )]TJ 0.105 Tw -8.747 -1.218 Td (\(\r\027\031\021\030\036\027\027\016\016 \030\036\022\021\026\035\034\027\ \026\016 \017\027\r\026\020\017\027\026\006\017\016, \027\026\030\031\032\ \027\024\036 \r\t)Tj 0 Tw (-)Tj 0.405 Tw T* (\023\026\007\036\027\017\036 \023\030\016\n\024\005 \022\017\001\022\017\ \) \024\023\030\036\007\036\035\016\036\021\f\016 \031\021\024\035\013\036\ \027\017\036 )Tj 0.189 Tw T* (\f\021\036\027\022\017 \022\017\001\022\017, \023\030\036\017\n\031\013\036\ \f\021\r\036\027\027\024, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \n\t\001\036\004\027\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\020\024)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\020\024 \017\035\017 \021\024\035\034\ \022\024 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016. )Tj 0.078 Tw T* [(\214\024\022\026\035\034\027\t\036 )0.5(\017\n\036\027\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\027\036 \016\r\036\027\027\024\020\024 )0.5(\007\036\235\036\022\021\026 )0.5(\b\026)]TJ 0 Tw (-)Tj -0.049 Tw T* (\030\026\022\021\036\030\017\031\033\021\f\016 \022\026\022 \017\n\036\ \027\201\027\027\t\005 \031\004\026\f\021\024\022 \f\021\036\027\022\017\ \022\017\001\022\017 )Tj -0.058 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\017\032\036\027\027\024\005 \220\b\024\020\036\027\027\024\f\ \021\034\033 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\036\007\017\027\017\021\036\035\034\027\024\021\022\026\027\027\024\005\ \023\030\024\f\035\024\005\022\017, \021.\036. \020\030\026\027\017\006\ \t \n\036\032\007\031 )Tj 0.146 Tw 0 -1.218 TD (\f\035\024\016\n\017 \f\n\026\026\027\t. \215\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\013\017\027\036 \f\035\017\017)Tj 0 Tw (-)Tj 0.115 Tw T* [(\f\021\024\005 \024\002\024\035\024\004\022\017 \024\023\030\036\007\036\ \035\016\033\021\f\016 )0.5(\r\f\036 \n\026\022\030\024\f\022\024\023\017\004\036\f\022\017\036 )]TJ 0.144 Tw T* (\r\026\030\017\026\027\021\t \222\242\215\025: \f\035\017\017\f\021\t\005\ \f\035\024\005 \f\024\b\030\026\027\201\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\030\017)Tj 0 Tw (-)Tj 0.114 Tw T* (\021\036\n\026\021\024\027\024\005 \235\024\030\n\036 \(\027\026 \235\024\ \027\036 \031\021\024\035\013\036\027\017\016 \r\f\036\005 \f\021\036\027\ \022\017 )Tj 0.03 Tw T* [(\022\017\001\022\017\), )0.5(\f\024\b\030\026\027\201\027 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.323 0 Td [(\031\021\024\035\013\036\027 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.501 0 Td [(\023\024\035\017\023\024\r\017\007\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.054 0 Td (\024\021)Tj 0 Tw (-)Tj 0.25 Tw -20.878 -1.218 Td (\f\031\021\f\021\r\031\036\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\016\r\036\027\027\024\005 [27,28]. \206\035\026\r\027\t\n\017 \007\017\ \235\235\036)Tj 0 Tw (-)Tj -0.028 Tw T* (\030\036\027\006\017\026\035\034\027\t\n\017 \031\035\034\021\030\026\r\ \031\022\024\r\t\n\017 \023\030\017\027\026\022\026\n\017 \027\036\024\023\ \035\026)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\021\017\004\036\f\022\024\020\024 \023\030\024\006\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\017\020\027\017\026\006\017\017 \222\242\215\025 \016\r\035\016\ \036\021\f\016 )Tj 0.277 Tw T* (\024\021\f\031\021\f\021\r\017\036 \030\026\030\031\001\036\027\017\016\ \n\t\001\036\004\027\024\020\024 \f\035\024\016 \022\017\001\036\004\027\ \024\005 )Tj 0.176 Tw T* (\f\021\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\030\027\t\b \035\017\n\235\026\021\017\004\036\ \f\022\017\b )Tj 0.134 Tw T* (\031\035\026\b [27]. \204\026\035\017\020\027\017\026\006\017\016 \222\ \242\215\025, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026)Tj 0 Tw (-)Tj 0.131 Tw T* (\021\031\030\t, \r\f\021\030\036\004\026\036\021\f\016 \007\024\f\021\026\ \021\024\004\027\024 \030\036\007\022\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\026 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\b \022\035\017\027\017\004\036\f\022\017\b\ \027\026\002\035\033\007\036\027\017\016\b)Tj /Span<>> BDC ( )Tj EMC ([8,26].)Tj /T1_2 1 Tf 1.027 Tw 0 -2.436 TD (\022\r\b\003\n\r\b\002\f\002\n\t\201\r\217\220\004\235 \240\r\226\r\220\002\ \n\006\004\226\t\235 )Tj /T1_1 1 Tf 0 Tw (\023\024\r\024\035\016\036\021 )Tj 0.479 Tw 0 -1.218 TD (\007\017\026\020\027\024\f\021\017\030\024\r\026\021\034 \f\021\036\023\036\ \027\034 \024\023\031\013\036\027\017\016 \023\030\024\n\036\032\027\024\ \f\021\017, )Tj 0.035 Tw T* [(\030\026\n\036\030 \030\036\022\021\024\006\036\035\036, \027\026\035\017\ \004\017\036 )0.5(\030\036\022\021\026\035\034\027\024\005 \017\027\r\026\020\017\027\026\006\ \017\017, )]TJ 0.184 Tw T* (\f\017\020\n\024\006\036\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\f\017\027\036\030\020\017\017 \n\t\001\006 \021\026\024\r\024\ \020\024 \007\027\026 [29]. )Tj 0.118 Tw T* (\025\026\022 \007\024\023\024\035\027\017\021\036\035\034\027\t\005 \n\036\ \021\024\007 \017\f\f\035\036\007\024\r\026\027\017\016 \007\035\016 \023\ \026\006\017)Tj 0 Tw (-)Tj 0.059 Tw T* [(\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.352 0 Td [(\030\036\022\021\026\035\034\027\t\n )0.6(\023\030\024\035\026\023\f\024\n )0.5(\017\f\023\024\035\034\031\036\021\f\016 )0.6(\030\036\027\021\020\036)]TJ 0 Tw (-)Tj 0.183 Tw -3.352 -1.218 Td (\027\024\035\024\020\017\004\036\f\022\024\036 \017\f\f\035\036\007\024\r\ \026\027\017\036 \023\026\f\f\026\032\026 \002\026\030\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj 0.154 Tw T* (\f\021\024\005 \022\017\001\022\036, \030\036\031\035\034\021\026\021\t\ \022\024\021\024\030\024\020\024 \017\027\021\036\030\023\030\036\021\017\ \030\031\033\021\f\016 )Tj 0.112 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \023\024\022\026\026\021\036\035\036\005 \007\036\ \235\036\022\024\020\030\026\235\017\017, \007\035\016 \031\021\024\004\027\ \036\027\017\016 )Tj 0.091 Tw T* (\235\031\027\022\006\017\024\027\026\035\034\027\t\b \024\f\024\002\036\027\ \027\024\f\021\036\005 \021\024\035\f\021\024\005 \022\017\001\022\017 \(\ \023\030\036)Tj 0 Tw (-)Tj 0.091 Tw T* (\024\002\035\026\007\026\027\017\036 \n\036\007\035\036\027\027\024-\021\ \030\026\027\017\021\027\024\020\024 \026\023\024\030\026 \017\035\017\ \220\r\026\022\031)Tj 0 Tw (-)Tj T* (\026\021\024\030\027\t\b \027\026\030\031\001\036\027\017\005\) [30].)Tj 0.049 Tw T* (\204\217\221 \024\030\020\026\027\024\r \n\026\035\024\020\024 \021\026\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\204\217-\007\036\235\036\022\024\020\030\026\235\017\016 \023\024\r\024\ )Tj 0 Tw (-)Tj 0.141 Tw T* (\035\016\033\021 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\021\ \034 \222\242\215\025 \024\021 \027\036\024\023\035\026\f\021\017\004\036\ \f\022\024\020\024 )Tj 0.087 Tw T* (\023\030\024\006\036\f\f\026 [5]. \203\036\n\026\035\024\r\026\032\027\t\ \n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \222\222\242\215\025 )Tj 0.457 Tw T* (\016\r\035\016\033\021\f\016 \235\031\027\022\006\017\024\027\026\035\034\ \027\t\036 \n\036\021\024\007\t \017\f\f\035\036\007\024\r\026\027\017\016\ . )Tj 0.147 Tw T* [(S)-16(kno)-16(os S.J. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1985\) \023\024\007\004\201\030\022\017\r\026\033\021\ , \004\021\024 \027\026\017)Tj 0 Tw (-)Tj 0.505 Tw T* (\002\024\035\036\036 \017\027\235\024\030\n\026\021\017\r\027\t\n \235\031\ \027\022\006\017\024\027\026\035\034\027\t\n \n\036\021\024\007\024\n )Tj 0.311 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \016\r\035\016\036\021\f\016 \ \026\027\024\030\036\022\021\026\035\034\027\026\016 \n\026\027\024\n\036\ \021\030\017\016 )Tj 0.158 Tw T* (\r\t\f\024\022\024\020\024 \030\026\030\036\001\036\027\017\016, \031\004\ \017\021\t\r\026\016, \004\021\024 \024\007\027\017\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.101 Tw T* [(\027\024\r\027\t\b \023\026\021\024\020\036\027\036\021\017\004\036\f\022\ \017\b )0.5(\235\026\022\021\024\030\024\r \030\026\r\017\021\017\016 \222\222\242\215\ \025 )]TJ 0.447 Tw T* (\016\r\035\016\033\021\f\016 \235\031\027\022\006\017\024\027\026\035\034\ \027\t\036 \027\026\030\031\001\036\027\017\016 \007\036\235\036\022\026\ \006\017\017 )Tj 0.448 Tw T* (\017\035\017 \027\036\007\024\f\021\026\021\024\004\027\024\f\021\034 \030\ \036\022\021\024\026\027\026\035\034\027\024\005 \022\024\024\030\007\017\ \027\026\006\017\017 )Tj 0 Tw T* ([31].)Tj /T1_3 1 Tf ( )Tj /T1_1 1 Tf 0.034 Tw 2.303 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \023\026\006\017\036\027\021\024\ \r \030\036\020\017\f\021\030\017)Tj 0 Tw (-)Tj 0.281 Tw -2.303 -1.218 Td [(\030\031\036\021\f\016 )0.6(\026\007\036\022\r\026\021\027\024\036 )0.5(\(\023\030\017 )0.5(III )0.6(\021\017\023\036 )0.5(\n\026\027\024\n\036\021\030\017\004\036\f\022\017\b )]TJ 0.04 Tw T* (\023\026\021\021\036\030\027\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\007\036\022\r\026\021\027\024\036 \(\023\030\017 IV )Tj ET 0 0 0 1 K 0.5 w q 1 0 0 1 274.9606 358.4899 cm 0 0 m 166.528 0 l S Q BT /T1_1 1 Tf 0.126 Tw 10 0 0 10 274.9606 724.8299 Tm (\021\017\023\036 \n\026\027\024\n\036\021\030\017\004\036\f\022\017\b \023\ \026\021\021\036\030\027\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017\) )Tj -0.02 Tw T* (\031\r\036\035\017\004\036\027\017\036 \007\026\r\035\036\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036, \f\024\023\030\024\r\024\032\ \007\026\033)Tj 0 Tw (-)Tj 0.038 Tw T* (\013\036\036\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\b \021\017\023\026\b \027\036\007\024\f\021\026\021\024\ \004\027\t\n \031\n\036\027\034\001\036\027\017\036\n )Tj 0.226 Tw T* [(\007\026\r\035\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\026\035\034\027\024\n )0.5(\022\026\027\026\035\036. \215\024)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n )0.5(\026\027\024)]TJ 0 Tw (-)Tj 0.138 Tw T* [(\030\036\022\021\026\035\034\027\024\005 \n\026\027\024\n\036\021\030\017\ \017 S)-16(kno)-16(os S.J. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1985\) )Tj -0.01 Tw T* [([31], M)-24(or)-37(io O. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2005\) [32] \002\t\035\024 \023\024\022\026\026\027\ \024, \004\021\024 )Tj 0.07 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \027\026\002\035\033\007\026\036\021\f\016 \007\017\ \f\f\017\027\036\030\020\017\016 \035\024\002)Tj 0 Tw (-)Tj 0.156 Tw 0 -1.218 TD (\022\024\r\024-\023\030\016\n\024\022\017\001\036\004\027\024\005 \n\t\001\ \006\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\007\024\022\f\026\035\034\027\t\n \f\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\022\030\026\013\036\027\017\036\n \026\027\026\035\034\027\024\020\024 \ \f\235\017\027\022\021\036\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (25\22682% \f\035\031\004\026\036\r, )Tj 0.015 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\201\027 \235\026\022\021 \030\026\r\017\ \021\017\016 \222\222\242\215\025 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\024\030\007\017)Tj 0 Tw (-)Tj -0.052 Tw T* (\027\017\030\024\r\026\027\027\024\005 \007\036\235\036\022\026\006\017\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\004\030\036\n\036\030\027\t\n \027\026\021\031\032\017\r\026\027\017\036\ \n)Tj /T1_3 1 Tf 0 Tw (.)Tj /T1_1 1 Tf ( )Tj 0.024 Tw T* (\221\026\022\032\036, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n M)-24(or)-36.9(io O. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [32], \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.425 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \030\036\020\017\f\021\030\017\030\024\r\026\035\026\ \f\034 \020\017\023\036\030\004\031\r\f\021\r\017\021\036\035\034\027\024\ \f\021\034 )Tj 0.098 Tw 0 -1.218 TD [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, \004\021\024 )0.5(\023\030\017\r\024\007\017\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\f\021\024\016\027\027\t\n )0.5(\023\024\t\r\026\n )]TJ 0.092 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\033 \017/\017\035\017 \024\013\031\013\036\ \027\017\033 \027\036\023\024\035\027\024\020\024 \024\023\024\030\024\032\ )Tj 0 Tw (-)Tj 0.213 Tw T* (\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\016\036\021\f\016 \017\002\t\021\024\004\027\t\n\ \027\026\023\030\016\032\036\027\017\036\n \r\024 )Tj 0 Tw T* (\r\030\036\n\016 \007\036\235\036\022\026\006\017\017)Tj /T1_3 1 Tf (.)Tj /T1_4 1 Tf 0 -2.436 TD (\f\n\002\004\207 \003\n\006\n\005\007\202)Tj /T1_1 1 Tf 0.474 Tw 0 -1.218 TD (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034, \023\ \024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n K)25(uck)10.1(elman)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj 0.051 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (Johnson E.K. \(2019\))Tj /T1_3 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.051 Tw 9.383 0 Td ([33], \n\024\032\027\024 \r\t\007\036\035\017\021\034 \f\035\036\007\031\ \033)Tj 0 Tw (-)Tj 0.101 Tw -9.383 -1.218 Td (\013\017\036 \n\036\021\024\007\t \035\036\004\036\027\017\016 \222\222\242\ \215\025: \022\024\027\f\036\030\r\026\021\017\r\027\t\005 \(\n\036\f\021\ )Tj 0 Tw (-)Tj -0.015 Tw T* (\027\026\016 \021\036\030\026\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \f\r\036\004\036\005, \022\035\017\ \n, \023\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\017)Tj 0 Tw (-)Tj 0.331 Tw T* (\f\021\036\n\027\026\016 \021\036\030\026\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \021\026\002\035\036\021\017\030\ \024\r\026\027\027\t\b )Tj 0.347 Tw T* (\023\030\036\023\026\030\026\021\024\r\) \022\026\022 \n\024\027\024\021\ \036\030\026\023\017\016 \017\035\017 \022\024\n\002\017\027\017\030\024\ \r\026\027)Tj 0 Tw (-)Tj 0.113 Tw T* (\027\t\005 \022\024\027\f\036\030\r\026\021\017\r\027\t\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\036\022\026\030\f\021\r\036\ \027\027\t\b )Tj 0.15 Tw T* (\023\030\036\023\026\030\026\021\024\r \022\026\022 \n\036\f\021\027\024\ , \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\024, \235\017\017\024\021\036\030\026)Tj 0 Tw (-)Tj 0.401 Tw T* (\023\036\r\021\017\004\036\f\022\017\005 \(\207\210\222-\021\036\030\026\ \023\017\016\), \220\027\007\024\f\022\024\023\017\004\036\f\022\017\005\ \(\021\024)Tj 0 Tw (-)Tj 0.364 Tw T* (\023\017\004\036\f\022\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\036 \035\036\004\036\027\017\036\)\ , \b\017\030\031\030\020\017\004\036\f\022\017\005 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\017\030\024\r\026\027\027\t\005)Tj /T1_3 1 Tf (.)Tj /T1_1 1 Tf T* (\025\024\027\f\036\030\r\026\021\017\r\027\t\036 \n\036\021\024\007\t \035\ \036\004\036\027\017\016 \222\222\242\215\025)Tj 0.129 Tw T* (\215\024 \007\026\027\027\t\n \f\017\f\021\036\n\026\021\017\004\036\f\022\ \024\020\024 \024\002\024\030\026, \r\t\023\024\035\027\036\027\027\024\ \020\024 )Tj 0.024 Tw T* [(Gour)-36.9(iou C. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2018\) [34], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\017\f\021\036\n\026\021\017\004\036)Tj 0 Tw (-)Tj 0.037 Tw T* (\f\022\024\020\024 \024\002\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\026\026\027\026\035\017\026 Qar)-37(i Y. \017)]TJ /Span<>> BDC ( )Tj EMC [(M)-24(osl)-31(i M. \(2020\) )]TJ 0.353 Tw T* [([35], \007\035\016 )0.5(\n\036\f\021\027\024\005 \021\036\030\026\023\017\017 )0.5(\222\222\242\215\025 \023\030\017\n\036\027\016\033\021 )0.5(\f\031)]TJ 0 Tw (-)Tj 0.096 Tw T* [(\022\030\026\035\034\235\026\021, )0.6(\f\026\035\017\006\017\035\026\021\t, )0.5(\020\035\033\022\024\022\024\030\021\017\022\024\f\021\036\030\024\017\007\ \t, )0.6(\f\031\035\034)]TJ 0 Tw (-)Tj 0.084 Tw T* (\235\026\f\026\035\026\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\026\035\026\n\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \035\036\022\026\030\f\021\r\036\027\027\t\ \b )Tj 0.194 Tw T* (\235\024\030\n\026\b \(\f\r\036\004\017, \022\035\017\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\027\026\), \f\017\f\021\036\n\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 \f\031\035\034)Tj 0 Tw (-)Tj 0.247 Tw T* (\235\026\f\026\035\026\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\021\017\022\024\f\021\036\030\024\017\007\t \(\r \021\026\002\ \035\036\021\017\030\024\r\026\027\027\024\005 )Tj 0 Tw T* (\235\024\030\n\036)Tj /T1_3 1 Tf (\).)Tj /T1_1 1 Tf 0.168 Tw [( Gour)-36.9(iou C. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\021\n\036\004\026\033\021, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n )Tj 0.581 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \022\024\027\f\036\030\r\ \026\021\017\r\027\024\020\024 \n\036\021\024\007\026 \035\036\004\036\027\ \017\016 )Tj 0.41 Tw T* (\222\222\242\215\025 \(\f\031\035\034\235\026\f\026\035\026\017\027, \f\ \031\022\030\026\035\034\235\026\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\026\035\026\n\017\027\) )Tj 0.077 Tw T* (\022\024\035\036\002\035\036\021\f\016 \024\021 28 \007\024)Tj /Span<>> BDC ( )Tj EMC (80%, \024\007\027\026\022\024 \004\026\f\021\024\021\026 \030\036\006\017\ \007\017\r\024\r )Tj 0.148 Tw T* (\007\024\f\021\017\020\026\036\021 50% [34]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \030\026\002\024\021\026\b \024\021\n\036\004\036\027\ \024, \004\021\024 )Tj 0.292 Tw T* (\027\036\024\021\255\036\n\035\036\n\024\005 \004\026\f\021\034\033 \f\017\ \f\021\036\n\027\024\020\024 \022\024\027\f\036\030\r\026\021\017\r\027\024\ \020\024 )Tj 0.078 Tw T* (\n\036\021\024\007\026 \035\036\004\036\027\017\016 \222\222\242\215\025\ \016\r\035\016\036\021\f\016 \n\024\007\017\235\017\022\026\006\017\016\ \023\024\r\036)Tj 0 Tw (-)Tj 0.004 Tw T* (\007\036\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \007\017\036\021\026, \024\002\024\020\026\013\036\027\ \027\026\016 )0.5(\022\035\036\021\004\026\021\022\024\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tw (-)Tj 0.024 Tw T* (\n\036\027\036\027\017\036 \f\035\026\002\017\021\036\035\034\027\t\b \f\ \030\036\007\f\021\r, \031\r\036\035\017\004\017\r\026\033\013\017\b \024\ \002\255)Tj 0 Tw (-)Tj T* (\201\n \022\026\035\024\r\t\b \n\026\f\f [34,35].)Tj 0.109 Tw T* [(\200 \021\024\032\036 \r\030\036\n\016 Qar)-37(i Y. \017)]TJ /Span<>> BDC ( )Tj EMC [(M)-24(osl)-30.9(i M. [35] \r)]TJ /Span<>> BDC ( )Tj EMC (\f\r\024\036\n \f\017\f\021\036)Tj 0 Tw (-)Tj 0.292 Tw T* (\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\036 \024\006\036\027\022\017 \220\235\ \235\036\022)Tj 0 Tw (-)Tj 0.212 Tw T* (\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \022\024\027\f\036\030\r\026\021\ \017\r\027\024\020\024 \035\036\004\036\027\017\016 )Tj 0.167 Tw T* (\222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\026\035\034\027\t\n \023\030\024\035\026\023\f\024\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\002\036, )Tj -0.035 Tw T* (\r\022\035\033\004\026\016 \022\024\n\002\017\027\017\030\024\r\026\027\027\ \t\005 \n\036\021\024\007)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\036\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4521 56.0378 Tm (159)Tj ET endstream endobj 521 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.226 Tw 10 0 0 10 70.8661 724.8299 Tm [(\210\007\027\026\022\024, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 5.089 0 Td [(\n\027\036\027\017\033 )0.6(F)10(r)-24(eimanis)]TJ /Span<>> BDC ( )Tj EMC 8.042 0 Td [(M.G. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.231 0 Td [(\f\024\026\r\021. )0.5(\(1991\) )]TJ 0.13 Tw -16.362 -1.218 Td ([18], \031\022\026\026\r\001\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \030\026\r\017\021\017\036 \023\026\021\024\035\024\ \020\017\004\036\f\022\017\b )Tj 0.257 Tw 0 -1.218 TD [(\017\n\036\027\036\027\017\005 )0.6(\r\024\n\024\032\027\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.635 0 Td [(\002\036 )0.5(\030\036\022\021\026\035\034\027\024\020\024 )0.6(\023\030\024\035\026\023\f\026, )]TJ 0.27 Tw -10.635 -1.218 Td (\002\024\035\036\036 \021\024\020\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\022\026\n\017 \r\027\031\021\030\036\027\027\036\005\ )Tj 0.038 Tw T* (\030\036\022\021\026\035\034\027\024\005 \017\027\r\026\020\017\027\026\006\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\026\007\036\027\017\036\n \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj T* (\022\017 \021\026\022\032\036 \027\036 \r\f\036\020\007\026 \030\026\r\017\ \r\026\036\021\f\016 \222\222\242\215\025.)Tj 0.075 Tw 0 -1.218 TD (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034 \030\ \026\002\024\021\031 He)Tj /Span<>> BDC ( )Tj EMC (C.C. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2023\) )Tj -0.047 Tw 0 -1.218 TD ([19], \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \r\t\f\022\026\026\027\t \023\030\036\007\023\ \024\035\024\032\036\027\017\016, \004\021\024 \222\222\242\215\025 )Tj -0.003 Tw T* (\016\r\035\016\036\021\f\016 \026\002\024\035\036\r\026\027\017\036\n \f\ )Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\024\005 \023\030\036\007\030\026\f\ \023\024\035\024)Tj 0 Tw (-)Tj 0.074 Tw T* (\032\036\027\027\024\f\021\034\033, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \n\017\f\f\036\027\f-\n\031\021\026\006\017\016\ \020\036\027\026 )Tj /T1_1 1 Tf 0 Tw [(C)14(HEK )]TJ 0.139 Tw T* (2p. H371Y)Tj /T1_0 1 Tf ( \n\024\032\036\021 \017\020\030\026\021\034 \030\036\001\026\033\013\031\ \033 \030\024\035\034 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.018 Tw T* (\r\017\021\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \023\030\024\020\027\024\036 \026\002\024\035\036\r\026\027\017\016\ . \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n )Tj 0.271 Tw 0 -1.218 TD (\007\026\027\027\024\020\024 \030\036\021\030\024\f\023\036\022\021\017\r\ \027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \023\024\022\ \026\026\027\024, )Tj 0.144 Tw 0 -1.218 TD (\004\021\024 \n\031\021\026\006\017\016 \020\036\027\026 )Tj /T1_1 1 Tf [(C)14(HEK 2p. H371Y)]TJ /T1_0 1 Tf ( \027\036 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\022\f)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\023\030\036\f\f\017\033 \002\036\035\022\026 )Tj /T1_1 1 Tf [(C)14(HEK 2\032.)]TJ /T1_0 1 Tf ( \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\t\b, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\030\026)Tj 0 Tw (-)Tj 0.083 Tw T* (\007\017\004\036\f\022\017\b \f\035\031\004\026\016\b \222\222\242\215\025\ , \027\024 \024\027\026 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 )Tj /T1_1 1 Tf -0.013 Tw T* [(C)14(HEK 2\032)]TJ /T1_0 1 Tf (., \004\021\024 \024\021\030\026\032\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\030\036\f\f\017\017 \027\017\032\036\f\021\024\016\013\017\ \b )Tj 0 Tw T* (\020\036\027\024\r: )Tj /T1_1 1 Tf -0.038 Tw 2.812 0 Td [(CDC )0.5(25A)]TJ /T1_0 1 Tf [( )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 4.051 0 Td [(p-P53 )0.5(\(Ser )0.6(20\).)]TJ /T1_0 1 Tf [( )0.5(\203\026)]TJ /Span<>> BDC ( )Tj EMC 7.512 0 Td [(\024\f\027\024\r\026\027\017\017 )0.6(\030\036\031\035\034)]TJ 0 Tw (-)Tj 0.176 Tw -14.376 -1.218 Td (\021\026\021\024\r \017\n\n\031\027\024\020\017\f\021\024\b\017\n\017\004\ \036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.034 Tw T* (\027\024\005 \030\026\002\024\021\036 \002\t\035\024 \023\030\024\007\036\ \n\024\027\f\021\030\017\030\024\r\026\027\024, \004\021\024 \r\026\030\017\ \026\006\017\017 )Tj 0.064 Tw T* (\031\030\024\r\027\016 \220\022\f\023\030\036\f\f\017\017 )Tj /T1_1 1 Tf (CDC 25A)Tj /T1_0 1 Tf ( \002\024\035\036\036 \027\026\004\017\021\036\035\034\027\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.043 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\t\n \026\027\026\n\027\036\024\n \222\222\242\215\025\ , \021\024\020\007\026 \022\026\022 \017)Tj 0 Tw (-)Tj 0.158 Tw T* (\n\036\027\036\027\017\016 \031\030\024\r\027\016 \220\022\f\023\030\036\ \f\f\017\017 )Tj /T1_1 1 Tf 0 Tw (p-P53)Tj /T1_0 1 Tf 0.158 Tw ( \002\024\035\036\036 \r\t\030\026\032\036\027\t )Tj 0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\030\026\007\017\004\036\f\022\017\b \f\035\031\004\026\016\b \ \026\002\024\035\036\r\026\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016, )Tj 0.314 Tw T* (\026\r\021\024\030\026\n\017 \024\021\n\036\004\036\027\t \024\020\030\026\ \027\017\004\036\027\017\016 \017\f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.345 Tw T* (\027\036\002\024\035\034\001\026\016 \004\017\f\035\036\027\027\024\f\021\ \034 \022\024\020\024\030\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )Tj 0.012 Tw T* (\023\026\006\017\036\027\021\024\r, \030\036\021\030\024\f\023\036\022\021\ \017\r\027\t\005 \b\026\030\026\022\021\036\030 \017\f\f\035\036\007\024\ \r\026\027\017\016, )Tj 0.079 Tw T* (\r \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \r\t\f\022\026\026\027\026 \027\036\024\002\b\024\007\017\n\024\ \f\021\034 \023\030\024\r\036\007\036\027\017\016 )Tj 0.207 Tw T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \022\024\027\021\ \030\024\035\017\030\031\036\n\t\b \017\f\f\035\036\007\024\r\026\027\017\ \005 )Tj 0.189 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\031 \n\031\021\026\006\017\017 \020\036\027\026 )Tj /T1_1 1 Tf [(C)14(HEK 2p.H371Y)]TJ /T1_0 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \030\024\035\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \222\222\242\215\025)Tj /T1_1 1 Tf (.)Tj /T1_0 1 Tf 0.049 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \222\222\242\ \215\025)Tj /Span<>> BDC ( )Tj EMC (\227 \026)Tj 0 Tw (-)Tj 0.046 Tw T* (\002\024\035\036\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\t\n \023\026\021\024\020\036\ \027\036\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\024 \022\024\027)Tj 0 Tw (-)Tj T* (\006\026 \027\036\016\f\027\024\005 \220\021\017\024\035\024\020\017\036\ \005.)Tj /T1_2 1 Tf 0 -2.436 TD (\021\f\t\b\t\220\004 \t)Tj /Span<>> BDC ( )Tj EMC (\240\t\004\n\b\002\217\003\t\220\004)Tj /T1_0 1 Tf 0.412 Tw 0 -1.218 TD (\207\024\035\034\001\017\027\f\021\r\024 \026\r\021\024\030\024\r \031\022\ \026\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\030\024\004\036\027\027\031\033 )Tj 0.354 Tw T* (\007\017\026\020\027\024\f\021\017\022\031 \222\222\242\215\025; \f\030\036\ \007\027\036\036 \r\030\036\n\016 \024\021 \023\024\016\r\035\036\027\017\ \016 )Tj 0.078 Tw T* (\f\017\n\023\021\024\n\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026 \f\024\ \f\021\026\r\035\016\036\021 5 \035\036\021 )Tj 0.112 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\034\017\030\031\036\021 \024\021 3 \n\036\f\016\006\036\r \007\ \024)Tj /Span<>> BDC ( )Tj EMC (30 \035\036\021 \031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b, \004\021\024 )Tj 0.305 Tw T* [(\002\024\035\034\001\036, )0.5(\004\036\n \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\007\036\021\f\022\024\020\024 )0.5(\r\024\030\026\f\021\026 \(1,2\226)]TJ 0 Tw T* (5,5)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\) [5,6,10].)Tj 0.556 Tw T* (\025\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036\027\ \017\016 \222\222\242\215\025, \r\036\f\034\n\026, \r\026\030\017\026)Tj 0 Tw (-)Tj 0.16 Tw T* (\002\036\035\034\027\t, \r\023\035\024\021\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017\b \024\021\f\031\021\f\021\r\017\016 [5,18]. \222\030\036\007\017 \024\ \002\255)Tj 0 Tw (-)Tj 0.396 Tw T* (\036\022\021\017\r\027\t\b \f\017\n\023\021\024\n\024\r \n\024\032\027\024\ \r\t\007\036\035\017\021\034 \030\036\022\021\026\035\034\027\024\036 )Tj 0.597 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\036, \024\002\017\035\034\027\ \024\036 \r\t\007\036\035\036\027\017\036 \f\035\017\017, \002\024\035\034\ )Tj 0.239 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036, \024\013\031\013\036\027\017\036 \027\036\023\024\ \035\027\024\005 \007\036)Tj 0 Tw (-)Tj 0.319 Tw T* (\235\036\022\026\006\017\017, \026\023\024\030, \007\035\017\021\036\035\ \034\027\024\036 \004\030\036\n\036\030\027\024\036 \027\026\023\030\016\ \032\036)Tj 0 Tw (-)Tj 0.11 Tw T* (\027\017\036 \r\024 \r\030\036\n\016 \007\036\235\036\022\026\006\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\036 \r\t\023\026\007\036\027\017\036 \023\030\016\n\024\005\ )Tj 0.203 Tw T* (\022\017\001\022\017 [5,6,11].)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.203 Tw 6.906 0 Td (\253\003\024\035\024\021\t\n\273 \f\021\026\027\007\026\030\021\024\n \007\ \017\026\020\027\024\f\021\017\022\017 )Tj 0.174 Tw -6.906 -1.218 Td (\222\222\242\215\025 \016\r\035\016\036\021\f\016 \022\024\035\024\027\024\ \f\022\024\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036\n \002\017\024)Tj 0 Tw (-)Tj 0.399 Tw T* (\023\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\n \017\ \f\f\035\036\007\024\r\026\027\017\036\n \n\026)Tj 0 Tw (-)Tj 0.325 Tw T* (\021\036\030\017\026\035\026. \222\030\036\007\017 \007\024\023\024\035\027\ \017\021\036\035\034\027\t\b \n\036\021\024\007\024\r \007\017\026\020\027\ \024\f)Tj 0 Tw (-)Tj 0.085 Tw T* (\021\017\022\017 \r\t\007\036\035\016\033\021 \023\026\035\034\006\036\r\ \024\036 \030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036, )Tj 0.344 Tw 23.244 64.543 Td (\030\036\022\021\024\030\024\n\026\027\024\f\022\024\023\017\033, \021\030\ \026\027\f\030\036\022\021\026\035\034\027\024\036 \031\035\034\021\030\026\ \r\031\022\024)Tj 0 Tw (-)Tj 0.252 Tw T* [(\r\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036, )0.5(\030\036\027\021\020\036\027\024\035\024\020\017\004\036\f\022\031\033 )0.6(\007\036\235\036\022\024\020\030\026)]TJ 0 Tw (-)Tj 0.241 Tw T* (\235\017\033, \n\026\027\024\n\036\021\030\017\033 \r\t\f\024\022\024\020\ \024 \030\026\030\036\001\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\020\027\017\021)Tj 0 Tw (-)Tj 0.074 Tw T* (\027\024-\030\036\024\027\026\027\f\027\031\033 \021\024\n\024\020\030\026\ \235\017\033 [5,6,7]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\006\036\r\024\n )Tj 0.378 Tw T* (\030\036\022\021\026\035\034\027\024\n \017\f\f\035\036\007\024\r\026\027\ \017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036\r )Tj 0.684 Tw T* (\024\023\030\036\007\036\035\016\036\021\f\016 \031\023\035\024\021\027\036\ \027\017\036 \017/\017\035\017 \023\026\021\024\035\024\020\017\004\036\f\ \022\026\016 )Tj 0.155 Tw 0 -1.218 TD (\023\024\007\r\017\032\027\024\f\021\034 \f\035\017\017\f\021\024\005 \024\ \002\024\035\024\004\022\017 \007\017\f\021\026\035\034\027\024\005 \004\ \026\f\021\017 )Tj -0.014 Tw 0 -1.218 TD (\(4\22610 \f\n \023\030\024\022\f\017\n\026\035\034\027\036\036 \r\027\031\ \021\030\036\027\027\036\020\024 \022\030\026\016 \026\027\026\035\034\027\ \024\020\024 )Tj 0.102 Tw T* [(\022\026\027\026\035\026\), \023\030\036\017\n\031\013\036\f\021\r\036\027\ \027\024, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \023\024\035\031\024\022\030\031\032)Tj 0 Tw (-)Tj 0.397 Tw T* [(\027\024\f\021\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\(\021\017\023\017\004\027\026\016 )0.5(\035\024\022\026\035\017\026\006\017\016 )0.6(\007\035\016 )]TJ 0.205 Tw T* (\222\222\242\215\025\), \017\035\017 \035\033\002\024\005 \007\030\031\020\ \024\005 \035\024\022\026\035\017\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032)Tj 0 Tw (-)Tj 0.195 Tw T* (\027\024\f\021\017; \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \f\035\031\004\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \006\017\030\022\031\035\016\030\027\024\036 \023\024\030\026\032\036\ \027\017\036. )Tj 0.108 Tw 0 -1.218 TD (\211\023\035\024\021\027\036\027\017\036 \n\024\032\036\021 \017\n\036\021\ \034 \031\035\024\r\026\021\031\033 \017\035\017 \023\024\035\017\023\024\ \r\017\007)Tj 0 Tw (-)Tj 0.371 Tw 0 -1.218 TD (\027\031\033 \235\024\030\n\031 [5,20].)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.371 Tw 8.848 0 Td (\233\027\007\024\f\022\024\023\017\004\036\f\022\017 \r\t\007\036\035\016\ \033\021 \016)Tj 0 Tw (-)Tj 0.113 Tw -8.848 -1.218 Td (\r\036\027\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\016\r\036\027\027\024\036 \023\024\030\026\032\036\027\017\036\ \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\t\030\036 \r\026\030\017\026\027\021\026 )Tj 0.081 Tw 0 -1.218 TD [(\222\242\215\025: )0.5(\220\030\017\021\036\n\026\021\024\027\t\005 )0.6(\(\26320%\), )0.5(\016\r\036\027\027\t\005 )0.6(\(\26355%\), )0.5(\023\024)]TJ 0 Tw (-)Tj 0.123 Tw T* (\035\017\023\024\r\017\007\027\t\005 \(\26324%\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\001\026\027\027\t\005 \(\2636%\). \242\r\036\027\027\t\005 )Tj -0.023 Tw T* [(\r\026\030\017\026\027\021 \b\026\030\026\022\021\036\030\017\031\036\021\ \f\016 )0.5(\027\026\035\017\004\017\036\n \016\r\036\027\027\024\020\024 \007\036\235\ \036\022)]TJ 0 Tw (-)Tj -0.013 Tw T* (\021\026 \030\026\035\017\004\027\024\005 \235\024\030\n\t \(\024\022\030\ \031\020\035\026\016, \024\r\026\035\034\027\026\016, \027\036\023\030\026\ \r\017\035\034)Tj 0 Tw (-)Tj 0.079 Tw T* (\027\026\016\), \020\035\031\002\017\027\t \(\004\026\013\036 \023\024\r\ \036\030\b\027\024\f\021\027\t\036, \027\024 \r\f\021\030\036\004\026\033\ \021\f\016 )Tj 0.181 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\017\036, \022\024\021\024\030\t\036 \027\036 \007\ \024\f\021\017\020\026\033\021 \n\t\001\036\004\027\024\020\024 \f\035\024\ \016 )Tj 0.009 Tw T* [(\f\021\036\027\022\017 )0.6(\022\017\001\022\017\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.014 0 Td [(\030\026\n\036\030\026 )0.5(\(\r )0.6(\f\030\036\007\027\036\n, )0.5(1,5\2262,0 )0.5(\f\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.731 0 Td (\007\017)Tj 0 Tw (-)Tj 0.02 Tw -20.745 -1.218 Td [(\026\n\036\021\030\036\). )0.5(\025\030\026\016 \016\r\036\027\027\024\020\024 )0.5(\007\036\235\036\022\021\026 )0.5(\n\024\020\031\021 \002\t\021\034 )0.5(\023\035\024\f\022\017)]TJ 0 Tw (-)Tj 0.097 Tw T* (\n\017, \023\035\024\f\022\024-\023\030\017\023\024\007\027\016\021\t\n\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\030\t\021\t\n\017, \026)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \016\r\t, )Tj 0.1 Tw T* (\022\026\022 \023\030\026\r\017\035\024, \030\024\r\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\030\t\021\024 \021\024\027\022\017\n \027\026\035\201\021\024\ \n \235\017)Tj 0 Tw (-)Tj 0.038 Tw T* (\002\030\017\027\026. \222\035\017\017\f\021\026\016 \024\002\024\035\024\ \004\022\026 \r\024\022\030\031\020 \016\r\t \027\036 \017\n\036\027\036\ \027\026 )Tj -0.023 Tw T* [(\017\035\017 )0.5(\020\017\023\036\030\036\n\017\030\024\r\026\027\026, )0.5(\f\024\f\031\007\017\f\021\t\005 )0.6(\030\017\f\031\027\024\022 )0.5(\f\n\026\026\027 )0.6(\017\035\017 )]TJ 0.233 Tw T* (\023\036\030\036\f\021\030\024\036\027. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\030\017\021\036\n\026\021\024\027\024\n \r\026\030\017\026\027\021\ \036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.108 Tw T* (\027\036\017\n\036\027\036\027\027\024\005 \f\035\017\017\f\021\024\005\ \024\002\024\035\024\004\022\017 \r\017\031\026\035\017\017\030\031\036\ \021\f\016 )Tj 0.29 Tw T* (\035\024\022\026\035\034\027\t\005 \031\004\026\f\021\024\022 \017\027\235\ \017\035\034\021\030\026\006\017\017, \004\026\013\036 \r\f\036\020\024 \ \023\024)Tj 0 Tw (-)Tj 0.319 Tw T* (\022\030\t\021\t\005 \002\036\035\036\f\024\r\026\021\t\n, \b\024\030\024\ \001\024 \f\n\t\r\026\036\n\t\n \027\026\035\201\021\024\n )Tj 0.011 Tw T* (\235\017\002\030\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\026\020\026\033\013\017\005\f\016, \022\026\022 \023\ \030\026\r\017\035\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007)Tj 0 Tw (-)Tj 0.159 Tw T* [(\027\036\005 \023\024\035\031\024\022\030\031\032\027\024\f\021\017 )0.5(\023\030\016\n\024\005 \022\017\001\022\017. \215\024\035\017\023\024\r\017\ \007\027\t\005 )]TJ 0.244 Tw T* (\r\026\030\017\026\027\021 \b\026\030\026\022\021\036\030\017\031\036\021\ \f\016 \027\026\035\017\004\017\036\n \n\027\024\032\036\f\021\r\036\027\ \027\t\b )Tj 0.173 Tw T* (\023\024\035\017\023\024\r\017\007\027\t\b \030\026\030\026\f\021\026\027\ \017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\036, )Tj 0.195 Tw T* (\f\035\017\r\026\033\013\017\b\f\016 \n\036\032\007\031 \f\024\002\024\005\ , \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \027\036\017\n\036\027\036\027\027\024\005 )Tj 0.215 Tw T* (\017\035\017 \020\017\023\036\030\036\n\017\030\024\r\026\027\027\024\005\ /\220\030\024\017\r\027\024-\r\024\f\023\026\035\036\027\027\024\005 \f\ \035\017)Tj 0 Tw (-)Tj T* (\017\f\021\024\005 \(\020\030\026\027\031\035\016\006\017\024\027\027\026\ \016 \021\022\026\027\034)Tj /T1_1 1 Tf (\))Tj /T1_0 1 Tf ( [9,20,21].)Tj /T1_2 1 Tf 0.331 Tw 0 -2.436 TD (\215\002\006\226\002\f\002\n\t\201\r\217\220\004\235 \220\004\006\003\t\b\ \004)Tj /T1_0 1 Tf ( \027\036\016\r\036\027\027\024\020\024 \r\026\030\017\026\027\021\026 \ )Tj 0.33 Tw 0 -1.218 TD (\222\242\215\025 \023\030\036\007\f\021\026\r\035\036\027\026 \020\017\023\ \036\030\021\030\024\235\017\036\005 \n\t\001\036\004\027\024\005 \023\035\ \026)Tj 0 Tw (-)Tj 0.142 Tw T* (\f\021\017\027\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\036\035\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\024\022\027\026, \022\024\021\024\030\t\036 \027\026\023\030\026\ \r)Tj 0 Tw (-)Tj 0.098 Tw T* (\035\016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\031\033 \024\002\024\035\024\004\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\201\n \023\030\024)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\016\032\036\027\017\017 \036\201 \f\024\002\f\021\r\036\027\027\024\ \005 \023\035\026\f\021\017\027\022\017. \215\030\024\035\017\235\036\030\ \026\006\017\016 )Tj -0.038 Tw T* (\020\035\026\007\022\024\n\t\001\036\004\027\t\b \r\024\035\024\022\024\027\ \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \235\017\002\030\024\ \024\n )Tj -0.019 Tw T* [(\030\026\027\024\005 )0.5(\f\021\036\023\036\027\017, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 7.49 0 Td [(\021\026\022\032\036 )0.5(\007\036\235\024\030\n\026\006\017\036\005 )0.6(\032\036\035\201. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.369 0 Td (\016)Tj 0 Tw (-)Tj 0.07 Tw -20.859 -1.218 Td (\r\036\027\027\024\n \r\026\030\017\026\027\021\036 \b\026\030\026\022\021\ \036\030\027\024 \023\030\024\035\026\002\017\030\024\r\026\027\017\036 \ \032\036\035\201 )Tj -0.01 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\235\030\026\020\n\036\027\021\024\r \f\024\002\f\021\r\036\027\027\024\005\ \023\035\026\f\021\017\027\022\017 \f\035\017\017\f\021\024\005 \024\002\ \024)Tj 0 Tw (-)Tj -0.034 Tw T* (\035\024\004\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\031\033 \024\f\027\024\r\031. \212\036\ \235\024\030\n\026\006\017\016 \022\030\017\023\021 \n\024)Tj 0 Tw (-)Tj -0.028 Tw T* (\032\036\021 \r\026\030\034\017\030\024\r\026\021\034 \024\021 \030\024\n\ \002\024\r\017\007\027\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\002\004\026\021\024\005 \235\024\030\n\t, )Tj -0.045 Tw T* [(\017\n\017\021\017\030\031\016 )0.6(\031\002\004\026\021\t\036 )0.5(\026\007\036\027\024\n\t )0.6([9,22,23].)]TJ /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf -0.045 Tw 15.977 0 Td [(\025\026\023\017\035\035\016\030\t )0.6(\007\017)]TJ 0 Tw (-)Tj -0.082 Tw -15.977 -1.218 Td (\035\026\021\017\030\024\r\026\027\t, \024\021\n\036\004\026\036\021\f\016\ \017\b \021\030\024\n\002\024. \222\035\036\007\031\036\021 \024\021\n\ \036\021\017\021\034, )Tj 0.112 Tw T* (\004\021\024 \023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\ \022\017 \017\027\024\020\007\026 \f\035\024\032\027\024 \007\017\235\235\ \036\030\036\027)Tj 0 Tw (-)Tj 0.034 Tw T* (\006\017\030\024\r\026\021\034 \027\036\016\r\036\027\027\t\005 \r\026\030\ \017\026\027\021 \f)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\017\n \022\017\f\021\024\027\t\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.7403 56.0378 Tm (158)Tj ET endstream endobj 520 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, \202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 711.1159 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc 0.14 Tw 8 0 0 8 42.5596 731.2159 Tm [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.145 Tw 14.294 0 Td [( Elena A. Bogd)26(anov)16(a, )0.5(Ryzhikh N)18(ational )0.5(Medical R)21(esearch )0.5(Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46(roctology)42.1(, Salyama )0.5(Adilya st., 2, )]TJ 0.023 Tw -14.299 -1.2 Td [(Moscow)52(, 123423, R)22(ussia; e-mail: info@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 16.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 16.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 651.7618 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf -0.023 Tw 10 0 0 10 42.5197 627.4058 Tm (\222\024\035\017\021\026\030\027\026\016 \016\r\026 \023\030\016\n\024\005\ \022\017\001\022\017 \(\222\242\215\025\))Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \007\024\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.027 Tw 0 -1.218 TD (\021\024\004\027\024 \030\036\007\022\024\036, \n\026\035\024\017\031\004\ \036\027\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\035\024\b\024 \023\024\007\007\026\033\013\036\036\f\016)10( )]TJ 0.117 Tw T* [(\035\036\004\036\027\017\033 \026\002\024\035\036\r\026\027\017\036, \027\ \036 \017\n\036\033\013\036\036 \f\023\036\006\017\235\017\004\036\f\022\ \017\b)10( )]TJ 0.296 Tw T* (\f\017\n\023\021\024\n\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\b\026\030\026\022\021\036\030\017\031\033\013\036\036\f\016 \022\024\n\ \023\035\036\022\f\024\n \022\026\022)10( )]TJ 0.442 Tw T* (\022\035\017\027\017\004\036\f\022\017\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \017\027\f\021\030\ \031\n\036\027)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.289 Tw T* (\021\026\035\034\027\t\b \023\030\024\016\r\035\036\027\017\005, \020\035\ \026\r\027\t\n \023\030\017\027\026\022\024\n \022\024\021\024\030\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.149 Tw T* (\020\024, \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\026\r\035\016\033\013\036\n \002\024\035\034\001\017\027\f\021\ \r\036 \f\035\031\004\026\036\r, \016\r\035\016\036\021\f\016)10( )]TJ 0.212 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\036 \016\r\036\027\027\024\020\ \024 \007\036\235\036\022\021\026 \f\035\017\017\f\021\024\005 \024\002\ \024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.514 Tw T* [(\035\024\004\022\017 \007\017\f\021\026\035\034\027\024\020\024 \024\021\ \007\036\035\026 \022\017\001\036\004\027\017\022\026. \200\023\036\030\r\ \t\036)9.9( )]TJ 0.195 Tw T* [(\024\023\017\f\026\035 )0.5(\024\007\017\027\024\004\027\031\033 )0.5(\016\r\031 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\023\026\021\024\035\024\020\024\026)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.12 Tw T* [(\027\026\021\024\n Cr)-22(uveilhier)]TJ /Span<>> BDC ( )Tj EMC (J. [1] \r)Tj /Span<>> BDC ( )Tj EMC (1829 \020\024\007\031, \026)Tj /Span<>> BDC ( )Tj EMC (\027\024\024\035\024\020\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.217 Tw T* [(\f\022\024\036 \027\026\017\n\036\027\024\r\026\027\017\036 \002\t\035\024\ \023\030\036\007\035\024\032\036\027\024 \002\030\017\021\026\027\f\022\ \017\n)10( )]TJ 0.126 Tw T* [(\b\017\030\031\030\020\024\n Ll)30(oyd-Dav)-16(ies)]TJ /Span<>> BDC ( )Tj EMC (O.V. \r)Tj /Span<>> BDC ( )Tj EMC [(1937 \020\024\007\031 [2]. \222\023\031\f\021\016)10( )]TJ -0.004 Tw T* (40 \035\036\021, \r)Tj /Span<>> BDC ( )Tj EMC (1969)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\031 Madigan)Tj /Span<>> BDC ( )Tj EMC (M.R. \017)Tj /Span<>> BDC ( )Tj EMC [(M)-24(or)-10(son B.C. \r\023\036\030)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.525 Tw T* (\r\t\036 \023\030\036\007\f\021\026\r\017\035\017 \007\026\027\027\t\036\ \024)Tj /Span<>> BDC ( )Tj EMC [(\f\017\n\023\021\024\n\024\022\024\n\023\035\036\022\f\036)10( )]TJ -0.029 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\ \026\022\026\b \007\026\027\027\024\020\024 \026\002\024\035\036\r\026\027\ \017\016)10( )]TJ 0.136 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \026\027\026\035\017\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\017\016 68)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\017\b)10( )]TJ 0.29 Tw T* (\f\035\031\004\026\036\r [2]. \200)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\034\027\036\005\001\036\n, Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(K.R.P. \(1975\),)10( )]TJ 0.545 Tw T* [(\031\004\017\021\t\r\026\016 \030\026\027\024\024\002\030\026\017\036 \ \022\035\017\027\017\004\036\f\022\017\b \f\017\n\023\021\024\n\024\r)10( )]TJ 0.528 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r \222\242\215\025, \024\023\030\036\007\036\035\017\035)10( )]TJ 0.14 Tw T* (\007\026\027\027\024\036 \026\002\024\035\036\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n \(\222\222\242\215\025\) [3]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.04 Tw T* (\f\021\024\016\013\036\036 \r\030\036\n\016 \030\016\007 \026\r\021\024\030\ \024\r \031\021\r\036\030\032\007\026\033\021, \004\021\024 \027\026\017\ \n\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.136 Tw T* [(\027\024\r\026\027\017\036 \026\002\024\035\036\r\026\027\017\016 \027\036\ \016\r\035\016\036\021\f\016 \022\024\030\030\036\022\021\027\t\n, \021\ \026\022)10( )]TJ 0.163 Tw T* [(Cr)-24(espo)]TJ /Span<>> BDC ( )Tj EMC [(P\351r)-24(ez)]TJ /Span<>> BDC ( )Tj EMC (L. \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. [4] \027\026\t\r\026\033\021 \222\222\242\215\025 \253\ T)47(he)9.9( )]TJ 0.069 Tw T* [(t)-13(hr)-24(ee-l)-30.9(ies disease\273/\253\002\024\035\036\027\034 \021\030\201\b\022\030\026\ \021\027\024\005 \035\032\017\273, \004\021\024)10( )]TJ 0.153 Tw T* (\020\024\r\024\030\017\021 \024)Tj /Span<>> BDC ( )Tj EMC [(\021\030\201\b \027\036\f\024\024\021\r\036\021\f\021\r\017\016\b, \020\007\ \036 \022\026\032\007\024\036 \f\035\024\r\024)10( )]TJ 0.094 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.82 0 Td [(\027\026\017\n\036\027\024\r\026\027\017\017 )0.5(\027\024\024\035\024\020\017\017 )0.5(\027\036 )0.5(\023\024\035\027\024\f\021\034\033 )0.5(\024\021\030\026\032\026\036\021)10( )]TJ 0.15 Tw -0.82 -1.218 Td (\030\036\026\035\034\027\031\033 \022\026\030\021\017\027\031 \026\002\024\ \035\036\r\026\027\017\016. \230\n\036\027\036\027\017\016 \f\035\017\017\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.007 Tw T* [(\f\021\024\005 \024\002\024\035\024\004\022\017 \007\017\f\021\026\035\034\ \027\024\020\024 \024\021\007\036\035\026 \022\017\001\036\004\027\017\022\ \026 \n\024\020\031\021)10( )]TJ 0.318 Tw T* (\r\026\030\034\017\030\024\r\026\021\034 \024\021 \020\017\023\036\030\036\ \n\017\017, \017\027\235\017\035\034\021\030\026\006\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\016)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.096 Tw T* (\r\036\027\027\024\020\024 \007\036\235\036\022\021\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\017\023\024\r\017\007\027\t\b \030\026\030\026\f\021\026\027\ \017\005, \020\007\036)10( )]TJ 0.238 Tw T* (\016\r\t \n\024\020\031\021 \002\t\021\034 \n\027\024\032\036\f\021\r\036\ \027\027\t\n\017, \026)Tj /Span<>> BDC ( )Tj EMC [(\035\024\022\026\035\017\026\006\017\016)10( )]TJ 0.136 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 \023\030\024\006\ \036\f\f\026 \027\036 \024\020\030\026\027\017\004\017\r\026\036\021\f\016\ \023\030\016)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.085 Tw T* (\n\024\005 \022\017\001\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\032\036\021 \030\026\f\023\030\024\f\021\030\026\027\016\021\034\f\ \016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.039 Tw T* [(\027\031\033 \021\030\036\021\034 \f\017\020\n\024\r\017\007\027\024\005\ \022\017\001\022\017 [5,6]. \003\026\002\024\035\036\r\026\036\n\024\f\021\ \034)10( )]TJ 0.043 Tw T* [(\222\222\242\215\025 )0.5(\f\024\f\021\026\r\035\016\036\021 )0.5(1\2263,6)]TJ /Span<>> BDC ( )Tj EMC 10.448 0 Td [(\f\035\031\004\026\036\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.866 0 Td [(100 )0.5(\021\t\f\016\004 )0.5(\027\026\f\036)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.041 Tw -15.314 -1.218 Td (\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\024\007, \024\007\027\026\022\024 \007\026\027\027\t\005 \023\024\022\ \026\026\021\036\035\034 \027\036 \016\r\035\016\036\021\f\016)10( )]TJ 0.293 Tw T* [(\017\f\021\017\027\027\t\n, \031\004\017\021\t\r\026\016 \001\017\030\024\ \022\017\005 \007\017\235\235\036\030\036\027\006\017\026\035\034\027\t\005\ )10( )]TJ 0.407 Tw T* [(\030\016\007 \026\002\024\035\036\r\026\027\017\005 \(\200\003\025, \220\ \027\007\024\n\036\021\030\017\024, \027\036\024\023\035\026\017\016\)\ )10( )]TJ 0.022 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\r\016\026\027\027\031\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\017\n \f\035\024\032\027\024\f\021\034 \023\024\f\021\026\027\024\ \r\022\017 \007\017\026\020\027\024\026)10( )]TJ -0.094 Tw T* ([5\2269]. \222\222\242\215\025 \f\021\030\026\007\026\033\021 \035\033\007\ \017 \r\f\036\b \r\024\030\026\f\021\027\t\b \022\026\021\036\020\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.01 Tw T* (\030\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\f\022\024\n \r\024\030\026\f\021\036 \007\026\027\027\024\036\ \026\002\024\035\036\r\026\027\017\036 \r\f\021\030\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.141 Tw T* (\004\026\036\021\f\016 \030\036\007\022\024, \024\007\027\026\022\024 \n\ \026\035\034\004\017\022\017 \002\024\035\036\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (3\2264)Tj /Span<>> BDC ( )Tj EMC [(\030\026\026)10( )]TJ -0.041 Tw T* [(\004\026\013\036 \007\036\r\024\004\036\022 [10]. \222\030\036\007\017 \r\ \030\024\f\035\024\020\024 \027\026\f\036\035\036\027\017\016 \004\026\013\ \036)10( )]TJ 0.154 Tw T* [(\002\024\035\036\033\021 \035\033\007\017 \n\024\035\024\007\024\020\024\ \r\024\030\026\f\021\026 \(\f\030\036\007\027\017\005 \r\024\030\026\f\ \021)9.9( )]TJ 0.085 Tw T* (30\22640)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\), \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n \023\030\036\024\002\035\026\007\026\027\ \017\036\n \031)Tj /Span<>> BDC ( )Tj EMC [(\032\036\027\013\017\027)10( )]TJ 0.049 Tw 23.244 57.237 Td ([5,6]. \222\222\242\215\025 \022\030\026\005\027\036 \030\036\007\022\024\ \r\f\021\030\036\004\026\036\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc T* (\035\024\020\024 \r\024\030\026\f\021\026)Tj /Span<>> BDC ( )Tj EMC ([11].)Tj /T1_5 1 Tf 0 Tc 0 -2.436 TD (\231\003\t\002\f\002\n\t\235 \t)Tj /Span<>> BDC ( )Tj EMC (\212\004\003\002\n\r\b\r\213)Tj /T1_4 1 Tf 0.923 Tw 0 -1.218 TD (\222\031\013\036\f\021\r\031\036\021 \n\027\024\020\024 \021\036\024\030\ \017\005 \023\026\021\024\020\036\027\036\026 \222\222\242\215\025. )Tj 0.154 Tw T* [(Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC (K.R. \017)Tj /Span<>> BDC ( )Tj EMC [(R)-24(iddell)]TJ /Span<>> BDC ( )Tj EMC (R.H. \r)Tj /Span<>> BDC ( )Tj EMC (1975 \020\024\007\031 \023\030\036\007\023\024\035\024\032\017)Tj 0 Tw (-)Tj 0.033 Tw T* (\035\017, \004\021\024 \222\222\242\215\025 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\036\005 \023\026\021\024\035\024\020\017\ \004\036\f\022\024\005 )Tj 0.384 Tw T* (\023\024\007\r\017\032\027\024\f\021\017 \f\035\017\017\f\021\024\005 \024\ \002\024\035\024\004\022\017 \007\017\f\021\026\035\034\027\t\b \024\021\ )Tj 0 Tw (-)Tj 0.179 Tw T* (\007\036\035\024\r \023\030\016\n\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \023\024\035\031\024\022\030\031\032\027\ \024\f\021\017, )Tj 0.037 Tw T* [(\021\022\026\027\036\r\024\005 )0.5(\017\001\036\n\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.362 0 Td [(\023\024\f\021\024\016\027\027\024\005 )0.5(\021\030\026\r\n\026\021\017\026\006\017\017 )0.6(\220\021\024\020\024 )]TJ -0.021 Tw -8.362 -1.218 Td (\031\004\026\f\021\022\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\n \027\026\021\031\032\017\r\026\027\ \017\017 \r\024 \r\030\036\n\016 \007\036\235\036)Tj 0 Tw (-)Tj -0.021 Tw T* (\022\026\006\017\017 [12]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\n\027\036\027\017\033 Du Boul)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC (C.E. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1983\), )Tj 0.157 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.91 0 Td [(\017\002\t\021\024\004\027\t\n )0.5(\f\024\022\030\026\013\036\027\017\017 )0.5(\035\024\002\022\024\r\024-\023\030\016\n\024\022\017\001\036\004)]TJ 0 Tw (-)Tj 0.041 Tw -1.91 -1.218 Td (\027\024\005 \n\t\001\006\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\017 \r\027\031\021\030\017\002\030\033\001\027\ \024\020\024 \007\026\r\035\036\027\017\016 )Tj 0.138 Tw T* (\023\036\030\036\007\027\016\016 \f\021\036\027\022\026 \023\030\016\n\024\ \005 \022\017\001\022\017 \023\030\024\035\026\002\017\030\031\036\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.064 Tw T* (\f\r\036\021 \022\017\001\022\017 \r\023\035\024\021\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, \023\036\030\ \036\022\030\t\r\026\016 )Tj 0.232 Tw T* (\036\020\024, \023\030\036\023\016\021\f\021\r\031\016 \007\036\235\036\022\ \026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 )Tj 0.109 Tw T* [(\026\002\024\035\036\r\026\027\017\016 )0.6(\004\026\f\021\034 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\n\024\032\036\021 )0.5(\f\007\026\r)]TJ 0 Tw (-)Tj 0.545 Tw T* (\035\017\r\026\021\034\f\016 \f\024\022\030\026\013\026\033\013\017\n\f\016\ \f\235\017\027\022\021\036\030\024\n, \031\f\031\020\031\002\035\016\016\ )Tj 0.15 Tw T* (\021\022\026\027\036\r\031\033 \017\001\036\n\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017\021\036\035\034\027\024 \021\030\026\r\n\017\ \030\031\016 \f\035\017)Tj 0 Tw (-)Tj 0.125 Tw T* (\017\f\021\031\033 [13]. \212\024)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\020\024 P)40(ar)-23.9(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (1966 \020\024\007\031 )Tj 0.05 Tw T* (\027\026\r\026\035\017 \007\026\027\027\t\005 \023\026\021\024\020\036\027\ \036\021\017\004\036\f\022\017\005 \023\030\024\006\036\f\f \n\036\b\026\ \027\017)Tj 0 Tw (-)Tj 0.023 Tw T* (\n\024\n \253\b\035\024\023\026\033\013\036\005 \026\f\035\024\027\022\017\ \273 [14]. \210\007\027\026\022\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 )Tj -0.026 Tw T* [(Ni)-16(v)]TJ /Span<>> BDC ( )Tj EMC 1.534 0 Td [(Y. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.708 0 Td [(\f\024\026\r\021. )0.5(\(1981\) )0.5([15], )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 8.504 0 Td [(\021\026\022\032\036 )0.5(Sadeghi)]TJ /Span<>> BDC ( )Tj EMC 6.033 0 Td [(A. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.781 0 Td (\f\024\026\r\021. )Tj 0.087 Tw -19.56 -1.218 Td [(\(2019\) [6] )0.5(\f\031\013\036\f\021\r\031\036\021 )0.5(\007\r\026 \024\f\027\024\r\027\t\b )0.5(\n\036\b\026\027\017\n\026 )0.5(\030\026)]TJ 0 Tw (-)Tj 0.297 Tw T* (\r\017\021\017\016 \026\002\024\035\036\r\026\027\017\016, \022\024\021\ \024\030\t\n\017 \016\r\035\016\033\021\f\016 \n\036\b\026\027\017\004\036\ )Tj 0 Tw (-)Tj 0.186 Tw T* (\f\022\017\005/\021\030\026\r\n\026\021\017\004\036\f\022\017\005 \(\b\030\ \024\027\017\004\036\f\022\017\005 \n\036\007\035\036\027\027\024-\021\030\ \026\027)Tj 0 Tw (-)Tj 0.303 Tw T* (\017\021\027\t\005 \026\023\024\030, \030\036\022\021\026\035\034\027\t\ \005 \023\030\024\035\026\023\f\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\031\007\017\f\021\t\005 )Tj 0 Tw T* (\(\017\001\036\n\017\016)Tj /T1_2 1 Tf (\))Tj /T1_4 1 Tf 0.179 Tw [(. \025\030\024\n\036 \021\024\020\024, T)40(and)-16(on)]TJ /Span<>> BDC ( )Tj EMC (R.K. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1990\) )Tj 0.17 Tw T* (\023\030\036\007\023\024\035\024\032\017\035\017, \004\021\024 \016\r\026\ \023\030\016\n\024\005 \022\017\001\022\017 \n\024\032\036\021 \002\t\021\ \034 )Tj 0.073 Tw T* (\023\030\024\016\r\035\036\027\017\036\n \f\017\f\021\036\n\027\024\020\024\ \026\002\024\035\036\r\026\027\017\016 \026\031\021\024\017\n\n\031\027\ \027\024)Tj 0 Tw (-)Tj 0.084 Tw T* (\020\024 \b\026\030\026\022\021\036\030\026 \017\035\017 \027\036\f\022\024\ \035\034\022\017\b \026\002\024\035\036\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004)Tj 0 Tw (-)Tj T* (\027\024\005 \220\021\017\024\035\024\020\017\036\005 [16].)Tj 0.215 Tw T* (\222\030\036\007\017 \235\026\022\021\024\030\024\r, \f\023\024\f\024\002\ \f\021\r\031\033\013\017\b \030\026\r\017\021\017\033 \222\222\242\215\025\ , )Tj 0.033 Tw T* (Madigan)Tj /Span<>> BDC ( )Tj EMC (M.R. \017)Tj /Span<>> BDC ( )Tj EMC [(M)-23.9(or)-10(son B.C. \017)]TJ /Span<>> BDC ( )Tj EMC [(\030\016\007 \007\030\031\020\017\b )0.5(\026\r\021\024\030\024\r \r\t)]TJ 0 Tw (-)Tj 0.119 Tw T* [(\007\036\035\016\033\021 )0.6(\021\030\026\r\n\026\021\017\026\006\017\033 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.724 0 Td (\n\026)Tj 0 Tw (-)Tj 0.005 Tw -20.724 -1.218 Td (\027\031\026\035\034\027\024\n \023\024\f\024\002\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \026\021\030\031\007\027\036\027\027\024\005 \007\ \036\235\036\022\026\006\017\017 )Tj 0.002 Tw T* [([2,17]. )0.6(\221\036\n )0.5(\027\036 )0.6(\n\036\027\036\036, )0.6(Contr)-32.9(a)-17(c)-16(t)17(or )0.5(T.Q. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.903 0 Td [(Contr)-33(a)-17(c)-15.9(t)17(or )0.5(Q.Q. )]TJ 0.415 Tw -15.903 -1.218 Td (\(1975\) \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \f\r\024\036\020\024 \017\f\f\035\036\007\024\r\026\ \027\017\016 \031\021\r\036\030\032\007\026)Tj 0 Tw (-)Tj 0.106 Tw T* (\033\021, \004\021\024 \007\026\027\027\t\005 \235\026\022\021\024\030 \027\ \036 \024\002\255\016\f\027\016\036\021 \235\024\030\n\017\030\024\r\026\ \027\017\036 )Tj 0.07 Tw T* [(\016\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\007\017\f\021\026\035\034\027\024\005 )0.5(\021\030\036\021\017 )0.5(\f\017\020\n\024\r\017\007\027\024\005 )0.5(\022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC 20.283 0 Td (\023\030\016)Tj 0 Tw (-)Tj 0.515 Tw -20.283 -1.218 Td [(\n\024\005 \022\017\001\022\036, \027\026\b\024\007\016\013\017\b\f\016 \ )0.5(\023\030\024\022\f\017\n\026\035\034\027\036\036 \r\t\f\024\021\t )]TJ 0 Tw T* (\023\026\035\034\006\026)Tj /Span<>> BDC ( )Tj EMC ([17].)Tj 0.048 Tw T* [(\200 \030\026\002\024\021\036 F)10(or)-31.9(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M., Dar)-32(v)-15.9(ishi)]TJ /Span<>> BDC ( )Tj EMC (M. \(2018 \020.\) [5], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.073 Tw T* (\032\036 Sadeghi)Tj /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2019\) [6] \031\022\026\t\r\026\036\021\f\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\021\024, )Tj 0.217 Tw T* (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\024\002\035\026\007\026\033\013\036\n \002\024\035\034\001\017\ \027\f\021\r\036 \f\035\031\004\026\036\r \222\222\242\215\025 )Tj 0.186 Tw T* (\030\026\r\017\r\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \r\027\031\021\030\036\027\027\036\005 \030\036\022\021\ \026\035\034\027\024\005 \017\027\r\026)Tj 0 Tw (-)Tj 0.213 Tw T* (\020\017\027\026\006\017\017 \017\035\017 \027\026\030\031\032\027\024\020\ \024 \r\t\023\026\007\036\027\017\016 \023\030\016\n\024\005 \022\017\001\ \022\017)Tj /T1_2 1 Tf 0 Tw (.)Tj /T1_4 1 Tf ( )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_6 1 Tf 25 0 0 25 505.5021 56.0378 Tm (157)Tj ET endstream endobj 516 0 obj [524 0 R] endobj 517 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 419.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 419.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 381.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 381.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 132.3176 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 132.3176 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 104.7097 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 104.7097 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-156-166)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 81.7489 695.3259 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, )]TJ 1.32 -1.105 Td [(\202\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022)-23.3(\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217 \r\022\ )-23.3(\020\004\225\004\t\n\206 )]TJ 0 Tw 5.889 -1.105 Td [(\(\025\255\212\025\005\022)-23.3(\020\n\026)11.1(\004\005\017\026)-20(\002\005\217\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 628.822 Tm [(\006\025\013)21(\202\017\t\025\b\017\022)-23.2(\240.\f)-31(.)]TJ 8.162 0 0 8.162 159.377 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 164.013 628.822 Tm [(, \001\r\005\n\202)-21(\020\004\b\016\r\n\221\022)-23.2(\001.\007.)]TJ 0 Tw 8.162 0 0 8.162 282.8933 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 287.5293 628.822 Tm [(, \035\n\r\002)-20(\026)11.1(\025\b\022)-23.3(\f)-31(.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 373.4258 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 10 0 0 10 70.8661 611.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.2(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, )]TJ 0 -1.2 TD [(\013)62(.\022)-23.3(\235\025\016\r\b\017,1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 587.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.127 Tw 9 0 0 9 119.0551 568.6488 Tm (\037\036\035\034: \022\016\r\007\022\023\017 \026\027\200\020\025\022\016\ \026\013 \032\020\016\021\022\023\022\t, \026\027\023\031\030\013 \030\022\ \020\b\025\031\024\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\t \024\022\025\030\032\031\026\020 \024\031\f\022\ \023\020\032\025\031\235 \t\016\021\013 \033\032\t\026\031\235 )Tj 0.257 Tw 0 -1.111 TD (\n\022\213\n\022 \(\205\205\226\004\202\), \021\n\f\005\007\020\t \021\031\ \016\026\031\255\025\031\024\023\017 \033\032\022\026\027\025\027\025\022\ \t \020\r\023\031\f\031\b\022\007\025\013\200 \024\023\021\031\f\031\021\ \013\200 \n\f\027\023\031\n \(\205\202\), \033\031\f\r\007\027\025\025\013\ \200 )Tj 0.023 Tw T* (\022\016)Tj /Span<>> BDC ( )Tj EMC (\255\022\032\031\021\031\235 \023\n\020\025\022 \(\234\).)Tj 0.157 Tw T* [(\205\022\025\030\032\031\026 )0.5(\024\031\f\022\023\020\032\025\031\235 \t\016\021\013 )0.5(\033\032\t\026\031\235 \n\022\213\n\022 )0.5(\(\205\205\226\004\202\))]TJ /Span<>> BDC ( )Tj EMC 21.814 0 Td [(\227 \204\023\031 )0.5(\200\032\031\025\022\007\027\024\n\031\027, )0.5(\032\027\006\022\030\022\021\022\032\r\005\212\027\027 \016\020\240\031\f\ \027\021\020\025\022\027, )0.5(\025\027 )]TJ 0.076 Tw -21.814 -1.111 Td (\022\026\027\005\212\027\027 \024\033\027\006\022\203\022\007\027\024\n\022\ \200 \024\022\026\033\023\031\026\031\021, \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\t\024\025\031\235 \204\023\022\031\f\031\b\022\027\235 \022)Tj /Span<>> BDC ( )Tj EMC (\033\020\023\031\b\027\025\027\016\031\026, \021\020\032\022\020\240\027\ \f\017\025\031\235 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\235\ )Tj 0.288 Tw 0 -1.111 TD (\n\020\032\023\022\025\031\235 \021\031\024\033\020\f\022\023\027\f\017\025\ \013\200 \022\016\026\027\025\027\025\022\235 \024\f\022\016\022\024\023\ \031\235 \031\240\031\f\031\007\n\022 \030\022\024\023\020\f\017\025\013\ \200 \031\023\030\027\f\031\021 \255\027\f\r\030\031\007\025\031-\n\022\213\ \027\007\025\031\b\031 )Tj 0.277 Tw 0 -1.111 TD (\023\032\020\n\023\020. \220\022\020\b\025\031\024\023\022\n\020 \205\205\ \226\004\202 \021)Tj /Span<>> BDC ( )Tj EMC (\033\032\027\031\240\f\020\030\020\005\212\027\026 \240\031\f\017\213\022\ \025\024\023\021\027 \024\f\r\007\020\027\021 \016\020\023\032\r\030\025\ \027\025\020. \217\240\212\027\b\031 \n\031\025\024\027\025\024\r\024\020\ )Tj 0.002 Tw T* (\033\031)Tj /Span<>> BDC ( )Tj EMC (\020\f\b\031\032\022\023\026\r \f\027\007\027\025\022\t \205\205\226\004\ \202 \025\020)Tj /Span<>> BDC ( )Tj EMC (\024\027\b\031\030\025\t\213\025\022\235 \030\027\025\017 \025\027\023. \ \211)Tj /Span<>> BDC ( )Tj EMC (\024\021\t\016\022 \024)Tj /Span<>> BDC ( )Tj EMC (\204\023\022\026 \026\027\023\031\030\013 \f\027\007\027\025\022\t \026\031\ \b\r\023 \240\013\023\017 \032\020\016\025\013)Tj 0 Tw (-)Tj 0.094 Tw T* (\026\022, \n\020\n \n\031\025\024\027\032\021\020\023\022\021\025\013\026\ \022, \023\020\n \022)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\022\026\022. \217\030\025\020\n\031\ \025\020)Tj /Span<>> BDC ( )Tj EMC (\025\020\024\023\031\t\212\022\235 \026\031\026\027\025\023 \025\027\023\ \032\020\025\030\031\026\022\016\022\032\031\021\020\025\025\013\200 )Tj 0.35 Tw T* [(\n\031\025\023\032\031\f\022\032\r\027\026\013\200 )0.5(\022\024\024\f\027\030\031\021\020\025\022\235, \022\016\r\007\020\005\212\ \022\200 )0.5(\031\023\030\020\f\027\025\025\013\027 )0.5(\032\027\016\r\f\017\023\020\023\013 \f\027\007\027\025\022\t. )0.5(\206\020\016\025\031\031\240\032\020\016\022\027 )0.5(\033\031\030\200\031\030\031\021 )]TJ 0.041 Tw T* (\n)Tj /Span<>> BDC ( )Tj EMC [(\f\027\007\027\025\022\005 )0.5(\205\205\226\004\202 \031\023\032\020\255\020\027\023 )0.5(\025\020\f\022\007\022\027 )0.5(\n\020\n \240\031\f\017\213\031\b\031 )0.5(\n\031\f\022\007\027\024\023\021\020 )0.5(\025\027\032\027\213\027\025\025\013\200 \021\031\033\032\031\024\031\021\ , \023\020\n \022)]TJ /Span<>> BDC ( )Tj EMC (\020\n\023\r\020\f\017\025\031\024\023\017 )Tj 0.023 Tw T* (\030\020\f\017\025\027\235\213\022\200 \022\024\024\f\027\030\031\021\020\ \025\022\235, \021\n\f\005\007\020\t \033\032\022\026\027\025\027\025\022\ \027 \n\f\027\023\031\007\025\013\200 \240\022\031\023\027\200\025\031\f\ \031\b\022\235.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.906 443.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \024\031\f\022\023\020\032\025\020\t \t\016\021\020 \033\032\t\026\031\235\ \n\022\213\n\022, \030\022\020\b\025\031\024\023\022\n\020 \024\031\f\022\ \023\020\032\025\031\235 \t\016\021\013, \f\027\007\027\025\022\027 \024\ \031\f\022\023\020\032\025\031\235 \t\016\021\013, \024\023\021\031\f\031\ \021\013\027 \n\f\027\023\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.036 Tc 0.344 Tw -10.401 -2.617 Td [(\020\036\017)5.1( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.026 Tc 0.349 Tw 9.558 0 Td ( \207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \222\022\030\017\007\035\036\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\222.\203., \214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \222\024\035\017\021\026\030\027\026\016 \016\r\026 \023\030\ \016\n\024\005 \022\017\001\022\017: \n\036\b\026\027\017\n\t \030\026\ )Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.17 Tw -9.563 -1.2 Td (\r\017\021\017\016, \007\017\026\020\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\036 \023\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \(\024\002\024\030 \035\017\021\036\030\026\ \021\031\030\t\). )Tj /T1_0 1 Tf -0.023 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.17 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(156\226166.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2026-25-1-156-166)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 119.8147 356.6332 Tm [(Solitar)-30.9(y r)31(ectal ulcer: mechanisms of\022)-23.3(de)11(v)12(elopment, )]TJ -1.29 -1.111 Td [(diagnosis and modern appr)20(oach)11(es to\022)-23.3(tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 312.1292 Tm [(Elena\022)-23.2(A)-31(.\022)-23.3(Bogdanov)10(a)]TJ 8.162 0 0 8.162 187.0589 316.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 191.6949 312.1292 Tm [(, Ser)31(gey\022)-23.2(N.\022)-23.3(Skridle)11(v)10(skiy)]TJ 0 Tw 8.162 0 0 8.162 325.5167 316.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 330.1526 312.1292 Tm [(, Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(Lik)11(utov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 440.6649 316.7912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 297.79 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 294.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 285.79 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 282.46 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_0 1 Tf 0.131 Tw 9 0 0 9 119.0551 251.9561 Tm [(The mechanis)33(ms of dev)13(elopment, methods of diagnosis and treatment of solitar)-43(y rectal ulcer syndrome \(SR)27.1(US\), )]TJ -0.022 Tw 0 -1.111 TD [(including the possibility of using autologous stem cells obtained from a\ dipose tissue in this pathology are descr)-37(ibed. )]TJ 0.035 Tw T* [(Solitar)-42.9(y ulcer syndrome of the rectum \(SR)27(US\) is a chronic, recur)-15.9(rent disease that does no)13(t hav)13(e specif)-42.9(ic sym)16(p)12.9(toms, )]TJ 0.009 Tw T* [(with unclear aetiology and pathog)12(enesis, v)16(ar)-37(iable endoscopic picture of inf)-22(lammator)-43(y chang)11.9(es in the mucous mem)]TJ 0 Tw (-)Tj -0.019 Tw T* [(brane of the rectum. Diagnosis of SR)27(US is dif)-40(f)-43(icult in the v)16(ast ma)10(jor)-36.9(ity of cases. There is no g)12.1(eneral consensus on the )]TJ 0.013 Tw 0 -1.111 TD [(algor)-36.9(ithms for treating SR)27(US to d)26(ate. T)56(reatment methods can be dif)-39.9(ferent, bo)13(th conser)-42(v)16(ativ)12.9(e and surgical. How)12(ev)13(er)61(, )]TJ 0.126 Tw 0 -1.111 TD [(at the moment there are no randomized controlled tr)-37(ials on late results of treatment. The v)16(ar)-36.9(iety of treatment )]TJ 0.052 Tw T* [(app)46(roaches of SR)27(US ref)-21.9(lects bo)13(th the p)46(resence of a larg)12(e number of unresolv)13(ed issues and the relev)16(ance of fur)-39.9(ther )]TJ 0.023 Tw T* [(research, including the use of cellular bio)13(technology)32.1(.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.906 156.6868 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( solitar)-42.9(y rectal ulcer)61.1(, diagnosis of)]TJ /Span<>> BDC ( )Tj EMC [(solitar)-42.9(y ulcer)61(, treatment of)]TJ /Span<>> BDC ( )Tj EMC [(solitar)-42.9(y ulcer)61(, stem cells)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.025 Tc -0.043 Tw -9.871 -2.617 Td [(F)3(O)-4.8(R)8.5( )0.5(C)-17.7(I)-15.8(T)45.2(A)37.3(T)-24.7(I)-1.5(ON:)]TJ /T1_3 1 Tf 0.012 Tc -0.035 Tw 6.248 0 Td [( )0.5(B)-14.1(o)-17.8(g)-11.6(d)-8.5(a)-6.7(n)-11.2(o)-9.5(v)-27.5(a)]TJ /Span<>> BDC ( )Tj EMC 5.068 0 Td [(E)-4.8(.)-23.1(A)-22.2(.)-22.7(,)0.5( )0.5(S)-11.8(k)-24.9(r)-55.6(i)-8(d)-10.4(l)-22.9(e)-15(v)-28.1(s)-10.3(k)-40.3(i)-16.4(y)]TJ /Span<>> BDC 7.277 0 Td ( )Tj EMC 0.21 0 Td [(S)-8.8(.)-1.1(N)-2(.)-22.7(,)0.5( )0.5(L)-11.4(i)-5.8(k)-14.1(u)-15.5(t)-21.1(o)-9.5(v)]TJ /Span<>> BDC 5.277 0 Td ( )Tj EMC 0.21 0 Td [(A)-22.2(.)-23.1(A)-22.2(.)0.5( )0.5(S)-24.4(o)-14.8(l)-15.9(i)-15(t)-36(a)-9.4(r)-59.8(y)0.5( r)-18.3(e)-18.2(c)-40.8(t)-35.9(a)-10.6(l)0.5( u)-7.6(l)-21.1(c)-8.9(e)-11.3(r)-23.9(:)0.5( )0.5(m)-15.8(e)-18.3(c)-9.4(h)-7.5(a)-6.8(n)-13.2(i)-6.6(s)-5.8(m)-10.8(s)0.5( o)-11.3(f)]TJ /Span<>> BDC 17.101 0 Td ( )Tj EMC 0.21 0 Td [(d)-14.5(e)-15(v)-17.9(e)-17.2(l)-20.1(o)-7.5(p)-12.2(m)-15.8(e)-10.7(n)-16.5(t)-52.4(,)0.5( )0.5(d)-15(i)-4.3(a)-10(g)-8(n)-11.2(o)-15(s)-25.3(i)-6.6(s)0.6( a)-6.8(n)-13.7(d)0.5( m)-11.6(o)-19.6(d)-14.5(e)-11.3(r)-35.1(n)12( )]TJ -0.005 Tc -0.048 Tw -41.605 -1.2 Td [(a)-8.2(p)-11.8(p)-13.1(r)-15.2(o)-17.6(a)-10.6(c)-9.6(h)-14.5(e)-22.3(s t)-21.3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-30.2(r)-18.5(e)-12.4(a)-17.7(t)-25.5(m)-16(e)-10.9(n)-16.8(t \()39.8(r)-18.5(e)-15.3(v)-51.2(i)-10.4(e)-11.9(w)20.1(\))11(. )]TJ /T1_0 1 Tf 0.001 Tc -0.001 Tw [(K)10.5(o)-3.5(lo)-3.5(p)-1(rok)-22.6(t)-1.2(o)-3.5(lo)-6.8(g)-16.6(i)3.3(a)2.4(.)]TJ /T1_3 1 Tf 0.003 Tc -0.056 Tw 20.513 0 Td [( 20)4.8(2)12.8(6)28.4(;)18.4(2)7.2(5)9.5(\()46.3(1)52.8(\))23.1(:)29.5(1)9.5(56)-17.4(\226)59.4(1)21.2(6)-2.2(6)13.5(.)8.3( \()7.7(i)5.4(n)8.3( R)2.1(u)-13.3(s)-13.7(s)-7(.)51.8(\))19(.)8.3( 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R)-24(isk f)16(a)-17(c)-16(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(post-end)-16(oscopic )]TJ 0.184 Tw -1.296 -1.25 Td [(submucosal )0.6(dissec)-15.9(t)-32(ion )0.6(elec)-16(tr)-32(o)-16(coa)-17(gul)-15.9(a)15(t)-32(ion )0.5(syndr)-31.9(ome )0.6(for )0.6(col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(neopl)-16(as)26(m)]TJ /T1_2 1 Tf 0.334 Tw (. J Gastroenterol Hepatol.)Tj /T1_1 1 Tf ( 2018 Dec;33\(12\):2001\2262006. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/jgh.14302)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2018 Jun 26. PMID: 29864790.)Tj 0.104 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(himur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Iw)-12(asak)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(H, Ozek)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. 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PMID: 38098318.)Tj 0.125 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)15(teinbr\374ck)]TJ /Span<>> BDC ( )Tj EMC 4.639 0 Td [(I, )0.5(Ebigbo)]TJ /Span<>> BDC ( )Tj EMC 4.036 0 Td [(A, )0.5(K)25.1(uellmer)]TJ /Span<>> BDC ( )Tj EMC 4.953 0 Td [(A, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.285 0 Td [(al. )0.5(Cold )0.6(V)30(er)-10(sus )0.6(Ho)17(t )0.5(Snar)-23.9(e )]TJ 0.109 Tw -17.209 -1.25 Td [(End)-16(oscopic R)13(esec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ar)-32(ge N)-14(on)11(peduncul)-16(a)15(ted Col)30(or)-23.9(ec)-16(t)15(al P)10(ol)35(yps: )]TJ 0.166 Tw T* [(R)-10(and)-16(omized Contr)-32(olled Ger)-15.9(man CHRONICLE )0.5(T)49.9(r)-36.9(ial. )]TJ /T1_2 1 Tf 0 Tw (Gastroenterology)Tj /T1_1 1 Tf (. )Tj 0.057 Tw 29.055 48.75 Td [(2024 Sep;167\(4\):764\226777. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1053/j.gastr)-31.9(o.2024.05.013)]TJ 0 0 0 1 k /GS1 gs 0.057 Tw ( Epub )Tj 0.023 Tw T* [(2024 Ma)15(y 23. 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(\027\026\004\017\021\036\035\034\027\024 \027\017\032\036, \004\036\n \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036: \002\ \024\035\034 )Tj 0.028 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036 3/107 \(2,8%\) \023\030\024\021\017\r 16/107 \(15\ %\), )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.028 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,01 )Tj 0.043 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.793 0 Td [(\035\017\b\024\030\026\007\022\026 )0.6(1/107 )0.5(\(1%\) )0.5(\023\030\024\021\017\r )0.6(9/107 )0.5(\(8%\), )]TJ /T1_1 1 Tf 0 Tw 17.918 0 Td (\032)Tj /T1_0 1 Tf 0.043 Tw /Span<>> BDC ( )Tj EMC 0.753 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td (0,05, )Tj 0.353 Tw -20.24 -1.218 Td [(\f\024\024\021\r\036\021\f\021\r\036\027\027\024. )0.6(\211\030\024\r\027\017 )0.5(\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.6(\n\026\030\022\036\030\024\r )]TJ 0.064 Tw T* (\022\030\024\r\017 \021\026\022\032\036 \002\t\035\017 \027\026\004\017\ \021\036\035\034\027\024 \027\017\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036, \023\024\035\031)Tj 0 Tw (-)Tj 0.226 Tw 0 -1.218 TD (\004\026\r\001\036\005 \026\027\021\017\002\017\024\021\017\022\017, \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 )Tj 0.323 Tw 0 -1.218 TD (\020\030\031\023\023\024\005: \035\036\005\022\024\006\017\021\024 2/10\ 7 \(1,8%\) \023\030\024\021\017\r 12/107 )Tj 0 Tw T* (\(11,2%\), )Tj /T1_1 1 Tf 3.589 0 Td (\032)Tj /T1_0 1 Tf -0.013 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,01 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\255\036\n \222-\030\036\026\022\021\017\r\027\024\020\024 \002\ \036\035\022\026 2/107 )Tj 0.12 Tw -3.589 -1.218 Td (\(1,8%\) \023\030\024\021\017\r 8/107 \(7,5%\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.12 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05 [15]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\036 )Tj 0.162 Tw T* [(S)-16(hi \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\031\033 \020\030\031\023\023\031 \002\ \t\035\024 \r\022\035\033)Tj 0 Tw (-)Tj 0.049 Tw T* (\004\036\027\024 38)Tj /Span<>> BDC ( )Tj EMC (\004\036\035\024\r\036\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\f\027\024\r\027\031\033 \020\030\031\023\023\031)Tj /Span<>> BDC ( )Tj EMC (\227 77 \004\036\035\024\r\036\022, )Tj 0.021 Tw 0 -1.218 TD (\027\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\ \005 )Tj 0.197 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \035\017\b\024\030\026\007\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\016 \031\030\024\r\027\016 \r\024\f\023\026\ )Tj 0 Tw (-)Tj 0.267 Tw 0 -1.218 TD (\035\017\021\036\035\034\027\t\b \n\026\030\022\036\030\024\r \022\030\024\ \r\017 \023\024\f\035\036 \031\007\026\035\036\027\017\016 \220\023\017\021\ \036)Tj 0 Tw (-)Tj 0.274 Tw T* (\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\ \017\005 \n\036\021\024\007\024\n \n\031\022\024\220\022\021\024\n\017\017\ )Tj 0.246 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\024\035\031\004\026\r\001\017\b\ \017\027\255\036\022\006\017\017 \035\036\r\024\235\035\024\022\f\026\006\ \017)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 3)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (0,4 \020\030\026\n\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \017\035\017 \006\036\235)Tj 0 Tw (-)Tj 0.235 Tw T* [(\021\026\017\007\017\n\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.244 0 Td [(\021\036\004\036\027\017\036 )0.6(3)]TJ /Span<>> BDC ( )Tj EMC 4.715 0 Td [(\007\027\036\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 3.927 0 Td [(1,0 )0.5(\020\030\026\n\n\031 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.983 0 Td (\f\031\021\022\017 )Tj 0.037 Tw -19.869 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \027\036 \023\024\035\031\004\026\ \r\001\017\b \026\027\021\017\002\026\022)Tj 0 Tw (-)Tj 0.058 Tw T* (\021\036\030\017\026\035\034\027\t\036 \023\030\036\023\026\030\026\021\t\ , 2/38 \(5%\) \023\030\024\021\017\r 0/77 \(0%\), )Tj 0.077 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024 [16]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 Zheng \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj -0.027 Tw T* (\021\026\022\032\036 \002\t\035 \023\030\024\r\036\007\036\027 \026\027\026\ \035\017 \030\026\r\017\021\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \035\017)Tj 0 Tw (-)Tj 0.056 Tw T* [(\b\024\030\026\007\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.478 0 Td [(\002\024\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.05 0 Td [(\032\017\r\024\021\036 )0.5(\023\024\f\035\036 )0.6(\r\t\023\024\035\027\036\027\027\024\005 )0.6(\n\031\022\024)]TJ 0 Tw (-)Tj 0.146 Tw -7.528 -1.218 Td [(\220\022\021\024\n\017\017. \215\026\006\017\036\027\021\026\n )0.5(\024\f\027\024\r\027\024\005 \020\030\031\023\023\t, \r\022\035\033\004\026\ \033\013\036\005 )]TJ 0.134 Tw T* (120)Tj /Span<>> BDC ( )Tj EMC (\004\036\035\024\r\036\022, \r\r\024\007\017\035\017 1,0 \020\030\026\n\n\ \006\036\235\017\022\f\017\n\026 \r\027\031\021\030\017)Tj 0 Tw (-)Tj -0.008 Tw T* (\r\036\027\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (30)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021 \007\024)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \036\013\036 \024\007\027\031 )Tj 0.318 Tw T* (\007\024\031 \026\027\021\017\002\017\024\021\017\022\026 \004\036\030\036\  6 \004\026\f\024\r \023\024\f\035\036 \024\023\036\030\026\006\017\017\ , )Tj -0.008 Tw T* (126)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \022\024\027\021\030\024\035\034\027\024\ \005 \020\030\031\023\023\t \r\t\023\024\035\027\016\035\017 \n\031\022\024\ )Tj 0 Tw (-)Tj -0.077 Tw T* [(\220\022\021\024\n\017\033 )0.5(\002\036 )0.6(\022\026\022\024\005-\035\017\002\024 )0.5(\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022\021\017\022\017. )]TJ 0.018 Tw T* (\204\036\032\007\031 \024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\024\005\ \027\036 \002\t\035\024 \r\t)Tj 0 Tw (-)Tj 0.14 Tw T* (\016\r\035\036\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 )Tj 0.096 Tw T* (\030\026\r\017\021\017\016 \035\017\b\024\030\026\007\022\017, \002\024\ \035\036\r\t\b \024\013\031\013\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 )Tj -0.012 Tw T* (\023\024\035\024\f\021\017 \017\035\017 \031\030\024\r\027\016 \r\024\f\023\ \026\035\017\021\036\035\034\027\t\b \n\026\030\022\036\030\024\r \022\030\ \024\r\017, )Tj 0.117 Tw T* (14/120 \(12%\) \023\030\024\021\017\r 13/126 \(10%\), \f\024\024\021\r\036\ \021\f\021\r\036\027\027\024 )Tj 0.331 Tw T* ([17]. \215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005\ \f\017\027\007\030\024\n \007\036\005\f\021\r\017\021\036\035\034\027\024\ )Tj 0.281 Tw T* (\027\036 \024\022\026\t\r\026\036\021 \030\026\007\017\022\026\035\034\027\ \024\020\024 \022\035\017\027\017\004\036\f\022\024\020\024 \r\035\017\016\ \027\017\016 )Tj -0.008 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.198 0 Td [(\021\036\004\036\027\017\036 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\023\036\030\017\024\007\026, )0.5(\024\007\027\026\022\024 )0.6(\r\t)]TJ 0 Tw (-)Tj 0.018 Tw -1.198 -1.218 Td [(\t\r\026\036\021 )0.6(\007\017\f\022\024\n\235\024\030\021 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.053 0 Td [(\023\026\006\017\036\027\021\024\r, )0.5(\021\030\036\002\031\036\021 )0.5(\023\030\024\r\036\007\036\027\017\036 )]TJ 0.138 Tw -9.053 -1.218 Td (\007\024\023\024\035\027\017\021\036\035\034\027\t\b \007\017\026\020\027\ \024\f\021\017\004\036\f\022\017\b \017\027\r\026\017\r\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.286 Tw T* (\017\027\r\026\017\r\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ . \221\026\022\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\017 )Tj 0.159 Tw T* (\007\026\027\027\024\020\024 \f\017\027\007\030\024\n\026 \r\024\027\017\ \022\026\036\021 \027\036\024\002\b\024\007\017\n\024\f\021\034 \027\026\ \027\026)Tj 0 Tw (-)Tj 0.512 Tw T* (\004\036\027\017\016 \f\017\f\021\036\n\027\t\b \026\027\021\017\002\026\ \022\021\036\030\017\026\035\034\027\t\b \023\030\036\023\026\030\026\021\ \024\r, )Tj 0.166 Tw T* (\r\r\017\007\031 \r\t\f\024\022\017\b \006\017\235\030 \f\036\023\021\017\ \004\036\f\022\017\b \n\026\030\022\036\030\024\r. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036)Tj 0 Tw (-)Tj 0.22 Tw T* [(\020\024\007\027\016\001\027\017\005 )0.6(\007\036\027\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.309 0 Td [(\n\036\007\017\006\017\027\f\022\024\n )0.5(\f\024\024\002\013\036\f\021\r\036 )0.6(\024\021\f\031\021)]TJ 0 Tw (-)Tj 0.188 Tw -8.309 -1.218 Td (\f\021\r\031\036\021 \036\007\017\027\026\016 \022\024\027\006\036\023\006\ \017\016 \027\036 \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 )Tj 0.072 Tw T* (\024\023\021\017\n\026\035\034\027\024\020\024 \026\027\021\017\002\026\022\ \021\036\030\017\026\035\034\027\024\020\024 \023\030\036\023\026\030\026\ \021\026, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r )Tj 0.017 Tw T* (\007\024\017\030\024\r\022\036, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\031\021\017 \036\020\024 \r\r\036\007\036\027\017\ \016 \007\035\016 \023\030\024\235\017\035\026\022)Tj 0 Tw (-)Tj 0.117 Tw T* (\021\017\022\017 \215\025\222. \203\036\024\002\b\024\007\017\n\t \004\036\ \021\022\017\036 \022\030\017\021\036\030\017\017 \007\035\016 \023\030\017\ \n\036)Tj 0 Tw (-)Tj 0.188 Tw T* (\027\036\027\017\016 \026\027\021\017\002\017\024\021\017\022\024\023\030\ \024\235\017\035\026\022\021\017\022\017 \023\036\030\036\007 \220\027\007\ \024\f\022\024\023\017)Tj 0 Tw (-)Tj 0.152 Tw T* (\004\036\f\022\017\n \031\007\026\035\036\027\017\036\n \220\023\017\021\ \036\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005 )Tj 0 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017.)Tj 0.2 Tw T* (\215\030\024\r\036\007\036\027\027\t\005 \n\036\021\026\026\027\026\035\017\  \023\024\022\026\026\035 \f\027\017\032\036\027\017\036 \004\026\f\021\ \024)Tj 0 Tw (-)Tj 0.126 Tw T* (\021\t \030\026\r\017\021\017\016 \023\024\f\021\022\024\026\020\031\035\ \016\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0.043 Tw 23.244 64.543 Td [(\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022\021\017\022\017 )0.7(\f)]TJ /Span<>> BDC ( )Tj EMC 12.206 0 Td [(16,1% )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 3.99 0 Td (5,9%, )Tj /T1_1 1 Tf 0 Tw 2.404 0 Td (p)Tj /T1_0 1 Tf 0.043 Tw /Span<>> BDC ( )Tj EMC 0.753 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td (0,04. )Tj 0.343 Tw -20.129 -1.218 Td [(\210\007\027\026\022\024 \023\024\035\031\004\036\027\027\t\036 \027\026\ \n\017 )0.5(\030\036\031\035\034\021\026\021\t \n\036\021\026\026\027\026\035\017\026\ )]TJ 0.151 Tw T* (\f\035\036\007\031\036\021 \017\027\021\036\030\023\030\036\021\017\030\024\ \r\026\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\024\030\024\032\027\024\f\021\034\033. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.198 Tw T* [(\027\t\005 \n\036\021\026\026\027\026\035\017 \r\022\035\033\004\036\027\ \t )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036 \017\f)]TJ 0 Tw (-)Tj 0.224 Tw T* (\f\035\036\007\024\r\026\027\017\016, \024\007\027\026\022\024 \007\026\027\ \027\t\036 \023\031\002\035\017\022\026\006\017\017 \002\t\035\017 \027\017\ )Tj 0 Tw (-)Tj 0.327 Tw T* (\022\024\020\024 \022\026\004\036\f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \031\030\024\r\027\036\n \020\036\021\036\030\024\020\ \036\027\027\024\f\021\017 )Tj 0 Tw 0 -1.218 TD (I)Tj 5.83 0 0 5.83 307.047 655.0919 Tm (2)Tj -0.024 Tw /Span<>> BDC 10 0 0 10 309.962 651.7618 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (80%. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \027\036 \r\f\036 \r\022\035\033\004\036\027\027\t\036 \017\f\ \f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.172 Tw -0.665 -1.218 Td (\027\017\016 \023\024\f\r\016\013\036\027\t \021\024\035\034\022\024 \220\ \027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\017\f\f\036\022\ \006\017\017 )Tj 0.151 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \023\024\035\024\ \r\017\027\026 \r\024\001\036\007\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 )Tj -0.038 Tw 0 -1.218 TD [(\017\f\f\035\036\007\024\r\026\027\017\005 \026\021\030\026\020\017\r\026\ \033\021 )0.5(\021\036\n\031 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \ )0.5(\030\036)]TJ 0 Tw (-)Tj 0 -1.218 TD (\036\022\006\017\017 \f\035\017\017\f\021\024\005 \024\002\024\035\024\ \004\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017.)Tj 0.397 Tw 0 -1.218 TD (\233\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \007\017\f\f\036\ \022\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 )Tj 0.261 Tw T* (\016\r\035\016\036\021\f\016 \n\026\035\024\017\027\r\026\017\r\027\024\ \005 \n\036\021\024\007\017\022\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \004\026)Tj 0 Tw (-)Tj -0.005 Tw T* (\f\021\024\021\024\005 \024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n \022\024\035\017\004\036\f\021\r\024\n\ \023\024\f\035\036)Tj 0 Tw (-)Tj 0.257 Tw T* [(\024\023\036\030\026\006\017\024\027\027\t\b )0.6(\022\024\005\022\024-\007\027\036\005, )0.6(\r\027\031\021\030\017\r\036\027\027\024\036 )0.5(\r\r\036\007\036\027\017\036 )]TJ 0.236 Tw 0 -1.218 TD (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\t\b \023\030\ \036\023\026\030\026\021\024\r \f\024\023\030\016\032\036\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024)Tj 0 Tw (-)Tj 0.141 Tw 0 -1.218 TD (\022\017\n \030\017\f\022\024\n \030\026\r\017\021\017\016 \022\026\022\ \n\036\f\021\027\t\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\t\b )Tj 0 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005.)Tj 0.579 Tw T* [(\210\021\035\017\004\017\021\036\035\034\027\024\005 )0.6(\024\f\024\002\036\027\027\024\f\021\034\033 )0.6(\023\036\030\024\030\026\035\034\027\024\020\024 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.227 Tw T* (\036\n\026 \023\030\036\023\026\030\026\021\024\r \016\r\035\016\036\021\ \f\016 \023\030\024\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\017\022\026\016 )Tj 0.428 Tw T* (\f\021\024\017\n\024\f\021\034 \007\026\027\027\024\020\024 \n\036\021\024\ \007\026 \023\030\024\235\017\035\026\022\021\017\022\017, \024\007\027\026\ \022\024 )Tj 0.216 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\007\024\f\021\031\023\027\024\005 \035\017\021\036\030\026\ \021\031\030\036 )Tj 0.247 Tw T* (\024\021\f\031\021\f\021\r\031\033\021 \007\026\027\027\t\036 \017\f\f\035\ \036\007\024\r\026\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\024\030\026\035\034\027\024\005 )Tj 0.637 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\036 \023\024\f\021\022\024\026\020\ \031\035\016\006\017)Tj 0 Tw (-)Tj 0.123 Tw T* (\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\024\f\035\036\ \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \031\007\026\ \035\036\027\017\016 )Tj -0.017 Tw T* (\220\023\017\021\036\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\ \026\024\r\026\027\017\005 \n\036\021\024\007\024\n \007\017\f\f\036\022\ \006\017\017 )Tj -0.007 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036. \037\036\035\036\ \f\024\024\002\030\026\027\024 \023\030\024\r\036\007\036\027\017\036 \017\ \f)Tj 0 Tw (-)Tj 0.176 Tw T* [(\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 6.63 0 Td [(\023\036\030\024\030\026\035\034\027\024\005 )0.6(\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022)]TJ 0 Tw (-)Tj -6.63 -1.218 Td (\021\017\022\036 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\ \027\024\020\024 \f\017\027\007\030\024\n\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 347.3118 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.223 Tw 10 0 0 10 303.3071 322.9558 Tm [(\215\030\024\r\036\007\036\027\017\036 )0.5(\r\027\031\021\030\017\r\036\027\027\024\005 )0.5(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 )0.6(\023\030\024)]TJ 0 Tw (-)Tj 0.534 Tw T* [(\235\017\035\026\022\021\017\022\017 )0.6(\023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\024\020\024\ )0.6(\f\017\027\007\030\024\n\026 )0.5(\023\036\030\036\007 )]TJ 0.372 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\017\f\f\036\ \022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 )Tj 0.115 Tw T* (\023\024\022\026\026\035\024 \220\235\235\036\022\021\017\r\027\024\f\021\ \034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\026\035\034)Tj 0 Tw (-)Tj 0.405 Tw T* (\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017\ \021\024\035\f\021\024\005 \022\017\001\022\017, \024\007\027\026\022\024\ )Tj 0.267 Tw T* (\007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\024\030\026\035\034\027\024\005 \026\027\021\017\002\017\024\ \021\017\022\024\023\030\024\235\017\035\026\022\021\017\022\036 )Tj 0.087 Tw T* (\024\021\f\031\021\f\021\r\031\033\021, \004\021\024 \021\030\036\002\031\ \036\021 \023\030\024\r\036\007\036\027\017\036 \023\030\024\f\023\036\022\ \021\017\r\027\t\b )Tj 0 Tw T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.365 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.375 Tw [( \004)-1.2(\031)-4(\b)-6.3(\031)-10.8(\024\031\021)-10( \001)18.8(.)33.7(\205)-12.1(.)-2.2(,)-9.9( )]TJ 0 Tc 0 Tw T* [(\035)14.6(\022)7.7(\n)-17.8(\r)2.1(\023)4(\031)9.7(\021 \003)-2.3(.)7.3(\003)-2.3(.)7.8(, \001)14.6(\020)0.6(\016)5.2(\020)1.8(\032\031)9.6(\021 \002)28.8(.)28.5(\211)24.3(.)]TJ /T1_0 1 Tf T* [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw [( \004)-1.1(\031)-4.1(\b)-6.3(\031)-10.8(\024\031\021)-9.9( \001)18.8(.)33.7(\205)-12.1(.)]TJ /T1_0 1 Tf 0.018 Tc -0.018 Tw T* [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw 11.349 0 Td [( \221)-5(\020)-15.1(\f\n)2.7(\020)-8.2(\032)-9.9(\031\021)-10( \003)-12.2(.)-2.7(\003)-12.3(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -11.349 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \004)-1.2(\031)-4(\b)-6.3(\031)-10.8(\024\031\021)-10( \001)18.8(.)33.8(\205)-12.1(.)-2.2(,)-10( \221)-5(\020)-15.2(\f\n)2.7(\020)-8.2(\032)-9.9(\031\021)-10( \003)-12.2(.)-2.7(\003)-12.3(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_1 1 Tf 0.722 Tw [( \221)5(\020)-5.2(\f)10.2(\n)12.7(\020)1.8(\032\031)9.6(\021 \003)-2.3(.)7.3(\003)-2.3(.)7.8(, \035)14.6(\022)7.7(\n)-17.8(\r)2.1(\023)4(\031)9.7(\021 \003)-2.3(.)7.3(\003)-2.3(.)7.9(, )]TJ 0 Tw T* [(\001)14.6(\020)0.6(\016)5.1(\020)1.8(\032\031)9.6(\021 \002)28.9(.)28.5(\211)24.3(.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.133 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.8(y)-11.8(:)]TJ /T1_1 1 Tf [( N)8(i)7.9(k)12.9(o)-1.1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(o)-4.4(g)-2.5(o)3.3(s)4.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.1(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, I)3.3(l)11(y)3.8(a V)53.1(. N)8.8(a)-4.5(z)12.9(ar)2.4(o)-0.6(v)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.8028 56.0378 Tm (154)Tj ET endstream endobj 533 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-10(\026\n\r\017 \224\025\016)-9.9(\026\r)10(\025\017\013)-20(\002\020\213\n\025\t\t\025\013)10.1(\025 )]TJ 0 -1 TD [(\016\n\t\202\005\025\024\017 \224\005\n\022\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 \002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\ \b\017\t\n\221 )]TJ T* [(\026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n \(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022\025\255\212\025\005\022\n\022\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 36.366 2 Td [(Antibacterial pr)31.1(e)10.9(v)12(ention of\022postcoagulation s)10(yndr)20(ome during )]TJ -2.695 -1 Td [(endoscopic r)31(emov)10(al of\022colon neoplasms \(r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.253 Tw 10 0 0 10 42.5197 724.8299 Tm (\215\025\222 \031\007\026\036\021\f\016 \030\026\030\036\001\017\021\034\ \022\024\027\f\036\030\r\026\021\017\r\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD [(\027\017\036\n )0.5(\f\017\f\021\036\n\027\t\b )0.6(\026\027\021\017\002\017\024\021\017\022\024\r, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.186 0 Td [(\027\036\022\024\021\024\030\t\b )0.6(\f\035\031\004\026\016\b )]TJ 0.286 Tw -14.186 -1.218 Td (\022\035\017\027\017\004\036\f\022\024\036 \021\036\004\036\027\017\036 \ \007\026\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\030\024\021\ \036\022\026\036\021 )Tj 0.011 Tw T* (\023\024\007 \n\026\f\022\024\005 \024\021\f\030\024\004\036\027\027\024\ \005 \023\036\030\235\024\030\026\006\017\017 \021\024\035\f\021\024\005\ \022\017\001\022\017, )Tj 0.196 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\024\032\036\021 \017\n\017\021\017\030\024\r\026\ \021\034 \023\036\030\017\021\024\027\036\026\035\034\027\031\033 \f\017\ \n\023)Tj 0 Tw (-)Tj 0.346 Tw T* (\021\024\n\026\021\017\022\031, \004\021\024 \023\030\017\r\024\007\017\021\ \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\033 \023\024\035\024\f\021\027\t\b )Tj 0.083 Tw 0 -1.218 TD (\b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\ \034\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\033 \030\036\r\017\017\017 )Tj 0.154 Tw 0 -1.218 TD (\024\030\020\026\027\024\r \002\030\033\001\027\024\005 \023\024\035\024\ \f\021\017 [10]. \222\017\n\023\021\024\n\t, \r\t\r\026\027)Tj 0 Tw (-)Tj -0.011 Tw T* (\027\t\036 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\ \t\n \f\017\027\007\030\024\n\024\n, \n\024\020\031\021 \017\n\036\027\017\ \021\034 )Tj -0.037 Tw T* [(\r\036\022\021\024\030 )0.5(\022\024\027\f\036\030\r\026\021\017\r\027\024\005 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\021\036\030\026\023\017\017. )]TJ 0.062 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\017 \215\025\222 \r)Tj /Span<>> BDC ( )Tj EMC (66,7% \f\035\031\004\026\036\r \023\026\006\017\036\027\021\026\n \027\026\ )Tj 0 Tw (-)Tj -0.015 Tw T* (\027\026\004\026\033\021 \f\017\f\021\036\n\027\t\036 \023\026\030\036\027\ \021\036\030\026\035\034\027\t\036 \026\027\021\017\002\026\022\021\036\030\ \017\026\035\034)Tj 0 Tw (-)Tj -0.014 Tw 0 -1.218 TD (\027\t\036 \023\030\036\023\026\030\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\021\036\030\024\017\007\027\t\036 \023\030\024\021\017\r\024\r\ \024\f\023\026\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.103 Tw 0 -1.218 TD (\027\t\036 \f\030\036\007\f\021\r\026, \004\021\024 \031\r\036\035\017\004\ \017\r\026\036\021 \f\030\024\022 \020\024\f\023\017\021\026\035\017\026\ \006\017\017 )Tj 0.065 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (3 \007\027\016, \f\021\024\017\n\024\f\021\034 \035\036\004\036\027\017\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (15%, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\027\017\032\026)Tj 0 Tw (-)Tj 0.22 Tw T* [(\036\021 )0.5(\022\026\004\036\f\021\r\024 )0.6(\032\017\027\017 )0.5(\023\026\006\017\036\027\021\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.678 0 Td (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )Tj 0.216 Tw -13.678 -1.218 Td (\023\036\030\017\024\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\007\035\017\027\036\027\017\036\n \023\036\030\017\024\007\026 \020\ \024\035\024\007\026\027\017\016 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\030\026\026 [7,3].)Tj 0.162 Tw T* (\025\035\026\f\f\017\235\017\006\017\030\031\033\021 \007\r\026 \021\017\ \023\026 \215\025\222)Tj /Span<>> BDC ( )Tj EMC (\227 I \021\017\023 \b\026\030\026\022\021\036\030\017)Tj 0 Tw (-)Tj 0.521 Tw T* (\031\036\021\f\016 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\ \027\027\t\n \f\017\027\007\030\024\n\024\n \002\036 \020\026\026 )Tj 0.085 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\024\035\017\004\036\f\022\024\005 \022\035\036\021\004\ \026\021\022\036; II \021\017\023 \b\026\030\026\022\021\036\030\017\031\ \036\021\f\016 )Tj -0.096 Tw T* (\023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\n \f\017\ \027\007\030\024\n\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \020\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.074 Tw T* [(\030\026\022\024\035\017\004\036\f\022\024\005 )0.6(\022\035\036\021\004\026\021\022\036. )0.5(\215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 )0.6(\f\017\027\007)]TJ 0 Tw (-)Tj -0.077 Tw T* (\030\024\n II \021\017\023\026 \f\024\023\030\024\r\024\032\007\026\036\021\ \f\016 \002\024\035\036\036 \016\030\022\024\005 \022\035\017\027\017\004\ \036\f\022\024\005 )Tj 0.245 Tw T* [(\022\026\030\021\017\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\035\017\004\017\036 \024\021 I )0.5(\021\017\023\026. \212\017\235\235\036\030\036\027\006\017\030\024\r\026\ \021\034 )]TJ 0.417 Tw T* (\007\026\027\027\t\036 \021\017\023\t \215\025\222 \f\021\026\027\024\r\017\ \021\f\016 \r\024\n\024\032\027\t\n \021\024\035\034\022\024 )Tj 0.093 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\017\017 \022\024\n\023\034\033\021\036\030\ \027\024\005 )0.5(\021\024\n\024\020\030\026\235\017\017 )0.5(\024\030\020\026\027\024\r )]TJ 0.11 Tw T* (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017. \200\t\016\r\035\ \036\027\027\t\005, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\031\004\036\r\024\005 )Tj 0.104 Tw T* (\007\017\026\020\027\024\f\021\017\022\017, \020\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\024\035\017\004\036\f\022\024\005 \022\035\036\021\004\ \026\021\022\036 \n\024\032\036\021 )Tj 0.061 Tw T* (\023\024\r\t\f\017\021\034 \030\017\f\022\017 \r\t\023\024\035\027\036\027\ \017\016 \026\002\007\024\n\017\027\026\035\034\027\024\020\024 \b\017\030\ \031\030)Tj 0 Tw (-)Tj T* (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 [6,8].)Tj 0.245 Tw T* (\200 \035\017\021\036\030\026\021\031\030\036 \022)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\n \235\026\022\021\024\030\026\n \030\017\f\022\026\ \023\024\f\021\022\024)Tj 0 Tw (-)Tj 0.583 Tw T* (\026\020\031\035\016\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\ \n\026 \024\021\027\024\f\016\021: \032\036\027\f\022\017\005 \023\024\035\ , )Tj 0.796 Tw T* [(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.5(\024\023\036\030\026\006\017\017 \002\024\035\036\036 )0.5(90 \n\017\027\031\021 )]TJ -0.064 Tw 23.244 40.187 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\024\032\036\027\017\036 \024\023\031\b\024\035\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024\007\024\004\027\ \024\005 )Tj 0.095 Tw T* (\022\017\001\022\017 [11]. \215\030\024\007\024\035\032\017\021\036\035\034\ \027\024\f\021\034 \024\023\036\030\026\006\017\017, \f\024\020\035\026\f\ \027\024 )Tj 0.383 Tw T* (\024\002\013\036\023\030\017\027\016\021\t\n \007\026\027\027\t\n, \016\r\ \035\016\036\021\f\016 \235\026\022\021\024\030\024\n \030\017\f\022\026\ )Tj -0.033 Tw T* (\030\026\r\017\021\017\016 \007\026\027\027\024\020\024 \f\017\027\007\030\ \024\n\026, \f\031\013\036\f\021\r\031\036\021 \023\030\016\n\026\016 \026\ \r\017)Tj 0 Tw (-)Tj 0.211 Tw T* (\f\017\n\024\f\021\034 \024\021 \030\026\n\036\030\024\r \031\007\026\035\ \016\036\n\024\020\024 \027\024\r\024\024\002\030\026\024\r\026\027\017\ \016, )Tj 0.037 Tw T* (\035\024\022\026\035\017\026\006\017\017 \036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024\007\024\004\027\ \024\005 \022\017\001\022\017 )Tj 0.052 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(\r\030\036\n\036\027\036\n \024\023\036\030\026\006\017\017 [12]. \230\f\ \f\035\036\007\024\r\026\027\017\036 Ar)-36.9(imo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj 0.189 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r\022\035\033\004\026\033\013\036\036 106 \023\026\006\ \017\036\027\021\024\r, \023\024\f\r\016\013\201\027\027\024\036 )Tj 0.195 Tw T* (\024\023\030\036\007\036\035\036\027\017\033 \235\026\022\021\024\030\024\ \r \030\017\f\022\026 \023\024\f\021\022\024\026\020\031\035\016\006\017\ \024\027\027\024\020\024 )Tj 0.079 Tw T* [(\f\017\027\007\030\024\n\026 )0.5(\023\024\022\026\026\035\024, )0.6(\004\021\024 )0.5(\r\030\036\n\016 )0.5(\r\t\023\024\035\027\036\027\017\016 )0.6(\220\027\007\024\f\022\024)]TJ 0 Tw (-)Tj 0.159 Tw T* (\023\017\004\036\f\022\024\005 \007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \002\024\035\036\036\ 90 )Tj 0.215 Tw T* (\n\017\027\031\021 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024\007\024\004\027\ \024\005 )Tj 0.424 Tw 0 -1.218 TD (\022\017\001\022\017 \016\r\035\016\033\021\f\016 \027\036\026\r\017\f\017\ \n\t\n\017 \235\026\022\021\024\030\026\n\017 \030\017\f\022\026 )Tj 0.102 Tw 0 -1.218 TD (\030\026\r\017\021\017\016 \215\025\222. \221\026\022\024\005 \235\026\022\ \021\024\030 \030\017\f\022\026 \022\026\022 \035\024\022\026\035\017\026\ \006\017\016 )Tj 0.039 Tw 0 -1.218 TD (\024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \021\024\035\f\021\024\005\ \022\017\001\022\017 \024\002\255\016\f\027\016\036\021)Tj 0 Tw (-)Tj -0.022 Tw T* (\f\016 \002\024\035\036\036 \021\024\027\022\024\005 \f\021\036\027\022\024\ \005 \024\030\020\026\027\026, \004\021\024 \f\023\024\f\024\002\f\021\r\ \031\036\021 \002\024)Tj 0 Tw (-)Tj 0.018 Tw T* (\035\036\036 \020\035\031\002\024\022\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\n\031 \030\026\f\023\030\024\f\021\030\026\027\036\027\ \017\033 \220\027\036\030\020\017\017 )Tj 0.064 Tw T* (\022\024\026\020\031\035\016\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\t\005 \f\035\024\005 \f\021\036\027\022\017 \022\017\ \001\022\017. \200\030\036\n\016 )Tj 0.065 Tw T* (\023\030\024\r\036\007\036\027\017\016 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \ \n\024\032\036\021 )Tj 0.214 Tw T* (\002\t\021\034 \f\024\022\030\026\013\036\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \023\024\r\t\001\036\027\017\016 \022\r\026\035\017\235\017\ \022\026\006\017\017 )Tj 0.101 Tw T* [(\024\023\036\030\017\030\031\033\013\036\020\024 \b\017\030\031\030\020\026\ )0.5([12]. \210\023\030\036\007\036\035\036\027\017\036 \235\026\022\021\024\030\ \024\r )]TJ 0.037 Tw T* [(\030\017\f\022\026 \023\024\r\024\035\017\021 \030\026\030\026\002\024\ \021\026\021\034 )0.5(\027\024\n\024\020\030\026\n\n\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026 )0.5(\007\024\024\023\036)]TJ 0 Tw (-)Tj 0.06 Tw T* (\030\026\006\017\024\027\027\024\n \220\021\026\023\036 \r\t\016\r\035\016\ \021\034 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017)Tj 0 Tw (-)Tj -0.028 Tw T* (\f\022\024\n \r\024\027\017\022\027\024\r\036\027\017\016 \215\025\222 \ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\006\036\035\034\027\024 \017\f\023\024\035\034\024\r\026\021\ \034 \031 )Tj 0 Tw T* (\027\017\b \026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\ \035\026\022\021\017\022\031.)Tj 0.087 Tw T* (\203\026 \007\026\027\027\t\005 \n\024\n\036\027\021 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\007\024\f\021\031\023\027\t\b \017\f\021\024\004\027\017\ \022\026\b \035\017)Tj 0 Tw (-)Tj 0.208 Tw T* (\021\036\030\026\021\031\030\t \017\n\036\033\021\f\016 \007\026\027\027\ \t\036 \021\024\035\034\022\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\r\036\027\027\024\005 )Tj 0.132 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\036 \023\024\f\021\022\024\026\020\ \031\035\016\006\017\024\027)Tj 0 Tw (-)Tj 0.029 Tw T* (\027\024\020\024 \f\017\027\007\030\024\n\026 \023\024\f\035\036 \r\t\023\ \024\035\027\036\027\027\024\005 \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\005 )Tj -0.039 Tw T* (\007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \030\026\027\007\024\n\017)Tj 0 Tw (-)Tj -0.034 Tw T* [(\017\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\ \017\016 L)35(ee)]TJ /Span<>> BDC ( )Tj EMC (SP. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r \022\024\021\024\030\024\n )Tj 0.14 Tw T* [(\023\030\017\027\016\035\017 )0.5(\031\004\026\f\021\017\036 \023\024)]TJ /Span<>> BDC ( )Tj EMC (50 \004\036\035\024\r\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (2 \020\030\031\023\023\026\b, \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 )Tj 0.003 Tw T* (\022\024\021\024\030\024\020\024 1,5 \020\030\026\n\n\026 \026\n\023\017\ \006\017\035\035\017\027-\f\031\035\034\002\026\022\021\026\n\026 \r\r\024\ \007\017)Tj 0 Tw (-)Tj 0.057 Tw T* (\035\017 \r\027\031\021\030\017\r\036\027\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (1 \004\026\f \007\024, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \004\036\030\036 8 \017)Tj /Span<>> BDC ( )Tj EMC (16)Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.026 Tw T* [(\f\024\r \023\024\f\035\036 \220\027\007\024\f\022\024\023\017\004\036\f\ \022\024\005 )0.5(\023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\022\006\017\017\ )]TJ 0.122 Tw T* (\002\t\035\024 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \027\024 \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\036 \030\ \026)Tj 0 Tw (-)Tj 0.368 Tw T* (\r\017\021\017\016 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\ \027\027\024\020\024 \f\017\027\007\030\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 )Tj 0.044 Tw T* (\020\030\031\023\023\036, 1/50 \(2%\) \023\030\024\021\017\r 8/50 \(16%\)\ , )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,031 [13]. )Tj 0.193 Tw T* [(\217\026\027\007\024\n\017\017\030\024\r\026\027\027\024\036 \017\f\f\035\ \036\007\024\r\026\027\017\036 S)-16(hichijo)]TJ /Span<>> BDC ( )Tj EMC (S. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.204 Tw T* (\026\r\021., \r\022\035\033\004\017\r\001\036\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036 \020\030\031\023\023\t 380 \004\036\035\024\r\036\022, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.329 Tw T* (\021\024\030\024\n 3 \020\030\026\n\n\026 \026\n\023\017\006\017\035\035\ \017\027-\f\031\035\034\002\026\022\021\026\n\026 \r\r\024\007\017\035\017\ )Tj 0.14 Tw T* (\r\027\031\021\030\017\r\036\027\027\024 \027\036\023\024\f\030\036\007\f\ \021\r\036\027\027\024 \023\036\030\036\007, \004\036\030\036 8 \004\026\ \f\024\r )Tj 0.135 Tw T* (\023\024\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \f\035\036\007\031\033\013\036\036 \031\021\030\024 \023\024\f\035\ \036 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 )Tj 0.185 Tw T* (\023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\022\006\017\017\ \027\036 \r\t\016\r\017\035\024 \f\031\013\036\f\021\r\036\027\027\t\b \ )Tj 0.081 Tw T* (\030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022)Tj 0 Tw (-)Tj -0.06 Tw T* (\021\017\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\036)Tj /Span<>> BDC ( )Tj EMC (\227 9/192 \(4,7%\) \023\030\024\021\017\r 14/188 \(7,5%\), )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.163 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,29 [14]. \200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(Zhang \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\026 )Tj 0.167 Tw T* (\023\030\024\017\r\036\007\036\027\026 \024\006\036\027\022\026 \030\026\ \r\017\021\017\016 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\ \027\027\024\020\024 )Tj 0.031 Tw T* (\f\017\027\007\030\024\n\026 \022\026\022 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\036\030\036\027\036\f\001\017\b \ \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.023 Tw T* [(\f\022\031\033 \007\017\f\f\036\022\006\017\033, )0.5(\021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\033; \r)Tj /Span<>> BDC ( )Tj EMC 16.812 0 Td (\022\024\027\021\030\024\035\034\027\024\005 )Tj 0.1 Tw -16.812 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\024\005 \020\030\031\023\023\036 \002\t\035\024 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (107 \004\036\035\024\r\036\022. \200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 )Tj -0.018 Tw T* [(\020\030\031\023\023\036 \023\026\006\017\036\027\021\026\n \r\r\024\007\ \017\035\017 )0.5(\006\036\235\031\030\024\022\f\017\n )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (1,5 \020\030\026\n\n\026 )Tj -0.041 Tw T* (\r\027\031\021\030\017\r\036\027\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\004\026\f\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\004\036\030\036 6 \004\026\f\024\r \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.137 Tw T* (\030\026\006\017\017. \232\026\f\021\024\021\026 \030\026\r\017\021\017\ \016 \002\024\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 )Tj ET q 42.52 111.77 184.252 192.872 re W n q /GS0 gs 184.2519685 0 0 192.8887796 42.5196838 111.7532492 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.148 Tw 9 0 0 9 42.5197 100.9701 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \202\020\007\027\024\023\021\031 \022\024\024\f\027\030\031\021\020\025\ \022\235, )0.6(\021\n\f\005\007\027\025\025\013\200 \021)]TJ /Span<>> BDC ( )Tj EMC 22.056 0 Td (\026\027\023\020)Tj 0 Tw (-)Tj -22.056 -1.2 Td (\020\025\020\f\022\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.01 Tc -0.035 Tw 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC [(q)14(uality of)]TJ /Span<>> BDC ( )Tj EMC (the studies included in the)Tj /Span<>> BDC ( )Tj EMC (meta-analy)Tj /Span<>> BDC ( )Tj EMC 23.588 0 Td (sis)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 505.4271 56.0378 Tm (153)Tj ET endstream endobj 534 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQa"q3B #$%&'()*2456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1A"2QaBq#R $%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?@`*FTh{\i-2;Pllg8Z׭OTkk1 9hԠNM0ZZAخƧ US-}aF @i֍֛֙Tasrnezt*5 {LI 3( oYssχRQc0tGb$') Y/mV pkze7pe6ւOw-.<)7-h%Ù;$j8@EkQ5l+Ҥ{8Vv8OQ{iu{kvmni,45+ 3\mg\֩Y^ƶq""" """е@`sXuĬ,꾛_5j m@Oh:NV:`{j=,vHIH@EE VSnql$ 1܀.Ѷs_TٜEH?mt]qHb +c.^[N 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\S2p-kϸ굪uGq1O<zMCMwS.4[I7߯59juz  lskGy&o~֞ZŎWjpyGK . sU%Zݼ&rXZQՖVIVҲ)V2F3mKznIIوPxsK,,uIوtseWT\[1oIKP{L5`D.}gm&ת)2Llܰ)"?IMƟY$%ReƍZFQZK[h2@[M-ozw&iu;:ZZ*sjhByq3hu,GgUivOW>3䖱eͪ,y=6B44kteց)޺VX7W6,HRZ/~zîcKW,~ŗSIRz]:tq|K;4[\T?J-2wWAi׵@`5{{[:軆؁Ru4Ri; Yz菪Pƪ[:럿e=~9V[5ُPm}~9V{p-jѯz^sECGI#pǤ]ocf>CF@EκO_|~f>Moc[__|~OYe,8S}B%r)}RIQM@"s]s짿>u?~kT1JIl[ m}~9V׀zq{k>zm6W@Rګ$sĮW[5ُPÌe$Gim}~9S:럿ejُS[aF1XIrl2EκY}fx.(>5I4 +I}R(à^bJ»ս潬%k8{s]sV{1JkT$->u?~{s]sV1JkT"߬l:+U7idFji:럿ejُS[cV+y# [__|~κZocf>@EUP5Vqz:n7Z@>j~9V[5ُV0m}~9S:럿ejُS[Imoo nږUAwQ0's̯E8$L(е@` endstream endobj 582 0 obj <>stream endstream endobj 531 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.406 Tw 10 0 0 10 70.8661 371.6679 Tm (\024\023\036\030\026\006\017\017, \021\026\022 \022\026\022 \017\027\f\031\ \235\235\035\017\030\024\r\026\027\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 )Tj 0.037 Tw 0 -1.218 TD (\022\017\001\022\017 \020\026 \r\024 \r\030\036\n\016 \024\023\036\030\026\ \006\017\017 \n\024\032\036\021 \021\026\022\032\036 \r\t\t\r\026\021\034\ )Tj 0 Tw T* (\002\024\035\017, \f\b\024\032\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\026\n\017 \215\025\222 [7].)Tj 0.227 Tw T* [(\222\024\020\035\026\f\027\024 \007\026\027\027\t\n \035\017\021\036\030\ \026\021\031\030\t, )0.5(\004\026\f\021\024\021\026 \023\024\f\021\022\024\026\020\031\035\016)]TJ 0 Tw (-)Tj 0.097 Tw T* [(\006\017\024\027\027\024\020\024 )0.5(\f\017\027\007\030\024\n\026 \n\024\032\036\021 )0.5(\007\024\f\021\017\020\026\021\034 )0.5(16% \024\021 \024\002\013\036\020\024 )]TJ 0.384 Tw T* (\022\024\035\017\004\036\f\021\r\026 \r\f\036\b \r\t\023\024\035\027\036\ \027\027\t\b \023\024\007\f\035\017\017\f\021\t\b \007\017\f)Tj 0 Tw (-)Tj 0.177 Tw T* (\f\036\022\006\017\005, \004\021\024 \027\026\004\017\021\036\035\034\027\ \024 \004\026\013\036, \004\036\n \023\024\f\035\036 \r\t\023\024\035\027\ \036)Tj 0 Tw (-)Tj 0.376 Tw T* (\027\017\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \023\ \024\035\017\023\220\022\021\024\n\017\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 )Tj 0.186 Tw T* (\007\026\027\027\t\005 \f\017\027\007\030\024\n \030\026\r\017\r\026\036\ \021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (4,4% \f\035\031\004\026\036\r [8,9]. )Tj 0.165 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC 5.709 0 Td [(\021\024, \004\021\024 )0.5(\002\024\035\034\001\017\027\f\021\r\024 \f\035\031\004\026\036\r )0.5(\030\026\r\017\021\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\ \025\023\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\f\r)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s b)-2.3(y g)-6.8(e)-7(n)-4.8(d)-5.3(e)-6(r)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 703.7118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 715.181 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 155.9055 703.7118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 156.1555 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 703.7118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 692.2426 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 692.2426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 692.2426 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 680.7813 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 680.7813 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 680.7813 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.32 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 669.32 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 669.32 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 657.8588 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 657.8588 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 657.8588 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 646.3975 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 646.3975 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 646.3975 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 634.9362 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 634.9362 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 224.187 634.9362 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 103.3919 700.8118 Tm (\032\003\002\006)Tj 14.26 0.717 Td (\200\002\f)Tj -4.273 -1.434 Td (\032\224\241)Tj 8.504 0 Td (\032\224+)Tj /T1_0 1 Tf -22.171 -1.433 Td (Lee et al.)Tj 12.212 0 Td (\204 68% \(34\))Tj 8.504 0 Td (\204 58% \(29\))Tj -20.716 -1.433 Td (Shichijo et al.)Tj 11.962 0 Td (\204 62% \(118\))Tj 8.504 0 Td (\204 61% \(115\))Tj -20.466 -1.433 Td (Zhang et al.)Tj 12.212 0 Td (\204 63% \(68\))Tj 8.504 0 Td (\204 58% \(62\))Tj -20.716 -1.433 Td (Shi et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Zheng et al.)Tj 12.212 0 Td (\204 52% \(63\))Tj 8.504 0 Td (\204 63% \(68\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 618.2169 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\ \025\023\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\032\020\024\023\r)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s b)-2.3(y a)-5.2(g)-6.8(e)]TJ ET /GS2 gs q 1 0 0 1 70.8661 602.9149 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 591.4457 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 602.9149 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 591.6957 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 602.9149 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 591.6957 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 580.2265 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 155.9055 591.4457 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 156.1555 580.2265 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 591.4457 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 580.2265 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 580.2265 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 579.9765 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 579.9765 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 579.9765 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 568.5152 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 568.5152 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 568.5152 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 557.0539 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 557.0539 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 557.0539 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 545.5927 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 534.3813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 545.5927 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 534.3813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 545.5927 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 534.3813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 534.1313 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 534.1313 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 534.1313 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 522.67 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 522.67 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 224.187 522.67 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 103.3919 588.5457 Tm (\032\003\002\006)Tj 13.399 0.717 Td (\026\002\213\006\004\217\003)Tj -3.412 -1.434 Td (\032\224\241)Tj 8.504 0 Td (\032\224+)Tj /T1_0 1 Tf -22.171 -1.433 Td (Lee et al.)Tj 11.86 0 Td (60,56)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (12,71)Tj 8.504 0 Td (61,52)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (12,86)Tj -20.364 -1.433 Td (Shichijo et al.)Tj 12.263 0 Td (69)Tj /Span<>> BDC ( )Tj EMC (\(35\22680\))Tj 8.504 0 Td (68)Tj /Span<>> BDC ( )Tj EMC (\(32\22680\))Tj -20.767 -1.433 Td (Zhang et al.)Tj 12.61 0 Td (63,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,5)Tj 8.254 0 Td (68,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (12,5)Tj -20.864 -1.433 Td (Shi et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Zheng et al.)Tj 12.11 0 Td (51,11)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,52)Tj 8.504 0 Td (52,74)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (8,89)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.156 Tw 9 0 0 9 70.8661 505.9508 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\032\031\030\031\f\255\022\023\027\f\017\025\031\024\023\017 \204\025\ \030\031\024\n\031\033\022\007\027\024\n\022\200 \021\026\027\213\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\023\027\f\017\024\023\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.001 Tc -0.001 Tw 3.318 0 Td [( D)-3.1(u)2.6(r)4.4(a)-8.2(t)-28.1(io)-3(n)1( o)5(f)]TJ /Span<>> BDC 4.707 0 Td ( )Tj EMC [(e)-6(n)-3.8(d)-4.2(os)1.1(c)3.8(o)-4.3(p)2.3(i)-0.8(c)1.1( i)4.9(nt)-0.6(e)-5(r)-41.8(v)3.3(e)-6(nt)-28.1(io)-3(n)4.7(s)]TJ ET /GS2 gs q 1 0 0 1 70.8661 479.8488 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 468.3796 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 479.8488 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 468.6296 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 479.8488 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 468.6296 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 457.1604 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 155.9055 468.3796 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 156.1555 457.1604 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 468.3796 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 457.1604 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 457.1604 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 456.9104 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 456.9104 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 456.9104 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 445.4491 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 445.4491 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 445.4491 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 433.9878 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 422.7765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 433.9878 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 422.7765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 433.9878 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 422.7765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 422.5265 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 411.3152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 422.5265 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 411.3152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 422.5265 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 411.3152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 411.0652 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 399.854 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 411.0652 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 399.854 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 411.0652 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 399.854 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 399.604 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 399.604 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 224.187 399.604 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 103.392 465.4796 Tm (\032\003\002\006)Tj 8.434 0.717 Td (\200\006\002\240\002\f\202\t\003\r\f\001\b\002\217\003\001 \002\212\r\006\ \004\204\t\005)Tj 1.552 -1.434 Td (\032\224\241)Tj 8.504 0 Td (\032\224+)Tj /T1_0 1 Tf -22.171 -1.433 Td (Lee et al.)Tj 11.86 0 Td (55,56)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (33,30)Tj 8.504 0 Td (61,40)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (56,55)Tj -20.364 -1.433 Td (Shichijo et al.)Tj 11.236 0 Td (86,0)Tj /Span<>> BDC ( )Tj EMC (\(78,3\22693,7\))Tj 8.504 0 Td (86,1)Tj /Span<>> BDC ( )Tj EMC (\(77,7\22694,5\))Tj -19.74 -1.433 Td (Zhang et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Shi et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Zheng et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.132 Tw 9 0 0 9 303.3071 730.483 Tm [(\020\004\206\f\t\204\004 )0.6(4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\206\020\024\033\032\027\030\027\f\027\025\022\027 )0.6(\025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 )0.7(\033\031)]TJ /Span<>> BDC ( )Tj EMC 20.507 0 Td (\f\031\n\020\f\022\016\020)Tj 0 Tw (-)Tj -20.507 -1.2 Td (\006\022\t\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(n)-2.3(e)-10.4(o)-5.3(p)-4.9(l)-1.1(a)-7.2(s)5.1(m)3.2(s b)-2.3(y l)-1.6(o)-12.5(c)3.2(a)-9.2(t)-29(i)-1.4(o)-4(n)]TJ ET /GS2 gs q 1 0 0 1 303.3071 704.381 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 691.778 cm 0 0 m 0 12.353 l S Q q 1 0 0 1 354.5807 704.381 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 692.028 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 439.6201 704.381 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 524.6594 692.028 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 303.5571 679.4249 cm 0 0 m 0 12.353 l S Q q 1 0 0 1 354.3307 691.778 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 354.5807 679.4249 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 439.6201 691.778 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 679.4249 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 524.6594 679.4249 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 303.3071 679.1749 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 354.5807 679.1749 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 439.6201 679.1749 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 524.6594 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 303.3071 618.5798 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 354.5807 618.5798 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 439.6201 618.5798 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 524.6594 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 303.3071 557.9846 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 354.5807 557.9846 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 439.6201 557.9846 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 524.6594 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 303.3071 506.9895 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 494.6443 cm 0 0 m 0 12.095 l S Q q 1 0 0 1 354.5807 506.9895 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 494.6443 cm 0 0 m 0 12.095 l S Q q 1 0 0 1 439.6201 506.9895 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 524.6594 494.6443 cm 0 0 m 0 12.095 l S Q q 1 0 0 1 303.3071 494.3943 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 354.5807 494.3943 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 439.6201 494.3943 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 524.6594 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 303.3071 433.7992 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 354.5807 433.7992 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 439.6201 433.7992 cm 0 0 m 85.289 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 318.825 688.878 Tm (\032\003\002\006)Tj 8.255 0.788 Td (\035\002\220\004\f\t\213\004\204\t\235 \b\002\002\002\206\006\004\213\002\ \004\b\t\005)Tj 0.669 -1.575 Td (\032\224\241)Tj 10.63 0 Td (\032\224+)Tj /T1_0 1 Tf -21.108 -1.574 Td (Lee et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 30% )Tj 3.887 -1.2 Td (\(15\))Tj -3.629 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 36% )Tj 3.629 -1.2 Td (\(18\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 34% )Tj 3.686 -1.2 Td (\(17\))Tj 6.743 6 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 40% )Tj 3.887 -1.2 Td (\(20\))Tj -3.629 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 28% )Tj 3.629 -1.2 Td (\(14\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 32% )Tj 3.686 -1.2 Td (\(16\))Tj -21.099 -1.574 Td (Shichijo et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 52% )Tj 3.887 -1.2 Td (\(99\))Tj -3.629 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 15% )Tj 3.629 -1.2 Td (\(28\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 33% )Tj 3.686 -1.2 Td (\(61\))Tj 6.743 6 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 53% )Tj 3.637 -1.2 Td (\(101\))Tj -3.379 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 18% )Tj 3.629 -1.2 Td (\(35\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 29% )Tj 3.686 -1.2 Td (\(56\))Tj -21.099 -1.574 Td (Zhang et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 25% )Tj 3.887 -1.2 Td (\(27\))Tj -3.99 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\026\016 )Tj 1.961 -1.2 Td (\022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 75%)Tj 2.029 -1.2 Td (\(80\))Tj 6.743 4.8 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 24% )Tj 3.887 -1.2 Td (\(26\))Tj -3.99 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\026\016 )Tj 1.961 -1.2 Td (\022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 76%)Tj 2.029 -1.2 Td (\(81\))Tj -21.099 -1.574 Td (Shi et al.)Tj 14.288 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -14.288 -1.574 Td (Zheng et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 39% )Tj 3.637 -1.2 Td (\(103\))Tj -3.379 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 42% )Tj 3.379 -1.2 Td (\(111\))Tj -3.436 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 19% )Tj 3.686 -1.2 Td (\(50\))Tj 6.743 6 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 39% )Tj 3.637 -1.2 Td (\(103\))Tj -3.379 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 41% )Tj 3.379 -1.2 Td (\(109\))Tj -3.436 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 20% )Tj 3.686 -1.2 Td (\(56\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 303.3071 417.0798 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \025\031\021\031\031\ \240\032\020\016\031\021\020\025\022\235 \033\031)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\026\027\032\020\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.323 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(n)-2.3(e)-10.4(o)-5.3(p)-4.9(l)-1.1(a)-7.2(s)5.1(m)3.2(s b)-2.3(y s)-12.5(i)7.9(z)7.9(e)]TJ ET /GS2 gs q 1 0 0 1 303.3071 401.7779 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 388.6078 cm 0 0 m 0 12.92 l S Q q 1 0 0 1 371.5886 401.7779 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 388.8578 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 448.124 401.7779 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 524.6594 388.8578 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 303.5571 375.6879 cm 0 0 m 0 12.92 l S Q q 1 0 0 1 371.3386 388.6078 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 371.5886 375.6879 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 448.124 388.6078 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 375.6879 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 524.6594 375.6879 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 303.3071 375.4379 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 375.4379 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 375.4379 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 362.2758 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 362.2758 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 362.2758 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 349.1137 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 371.5886 349.1137 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 448.124 349.1137 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 524.6594 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 303.3071 287.9516 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 287.9516 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 287.9516 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 274.7896 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 274.7896 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 274.7896 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 261.6275 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 371.5886 261.6275 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 448.124 261.6275 cm 0 0 m 76.785 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 327.3289 385.7079 Tm (\032\003\002\006)Tj 9.534 0.823 Td (\022\004\213\214\r\006 \b\002\002\002\206\006\004\213\002\004\b\t\005)Tj -0.079 -1.646 Td (\032\224\241)Tj 9.567 0 Td (\032\224+)Tj /T1_0 1 Tf -21.64 -1.645 Td (Lee et al.)Tj 10.515 0 Td (20,42)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (8,22)Tj 9.567 0 Td (20,56)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (8,90)Tj -20.082 -1.645 Td (Shichijo et al.)Tj 10.669 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(20\22660\))Tj 9.567 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(20\22660\))Tj -20.236 -1.645 Td (Zhang et al.)Tj 9.424 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (10 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 17,8% )Tj 2.639 -1.2 Td (\(19\))Tj -3.05 -1.2 Td (10\22620)Tj /Span<>> BDC ( )Tj EMC (\n\n)Tj /Span<>> BDC ( )Tj EMC (\227 60,7% )Tj 3.05 -1.2 Td (\(65\))Tj -2.639 -1.2 Td (>)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 21,5% )Tj 2.639 -1.2 Td (\(23\))Tj 6.928 6 Td (<)Tj /Span<>> BDC ( )Tj EMC (10 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 20,5% )Tj 2.639 -1.2 Td (\(22\))Tj -3.05 -1.2 Td (10\22620 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 56,1% )Tj 3.05 -1.2 Td (\(60\))Tj -2.639 -1.2 Td (>)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 23,4% )Tj 2.639 -1.2 Td (\(25\))Tj -21.63 -1.645 Td (Shi et al.)Tj 11.379 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj 9.567 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj -20.946 -1.645 Td (Zheng et al.)Tj 10.968 0 Td (10\22620 \n\n)Tj 9.567 0 Td (10\22620 \n\n)Tj ET q 70.866 122.703 453.543 123.344 re W n q /GS0 gs 453.543294 0 0 123.3445784 70.8661499 122.7032427 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.048 Tw 9 0 0 9 70.8661 111.7701 Tm [(\022\t\217\210\b\002\220 )0.5(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \220\032\027\021\031\021\022\030\025\013\235 )0.6(\b\032\020\203\022\n )0.5(\026\027\023\020\020\025\020\f\022\016\020: )0.5(\021\f\022\t\025\022\027 )0.5(\020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\031\235 )0.5(\033\032\031\203\022\f\020\n\023\022\n\022 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 40.536 0 Td (\032\020\016\021\022\023\022\027 \033\031\024\023\n\031\020\b\r\f\t)Tj 0 Tw (-)Tj -40.536 -1.2 Td [(\006\022\031\025\025\031\b\031 \024\022\025\030\032\031\026\020 \033\031\ \024\f\027 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\b\031 \r\ \030\020\f\027\025\022\t \204\033\022\023\027\f\022\020\f\017\025\013)0.6(\200 \025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\031\ \f\024\023\031\235 \n\022\213\n\022)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.037 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC 5.485 0 Td [(ef)-40(fect of)]TJ /Span<>> BDC ( )Tj EMC [(antibacter)-37(ial )0.5(p)46(roph)12(ylaxis )0.5(on )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(dev)13(elopment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 22.121 0 Td [(postcoagulation )0.5(syndrome af)-46(ter )0.5(endoscopic )0.5(remov)16(al )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (epi)Tj 0 Tw (-)Tj -27.606 -1.2 Td [(thelial neoplas)33.1(ms of)]TJ /Span<>> BDC ( )Tj EMC (the colon)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.7153 56.0378 Tm (152)Tj ET endstream endobj 532 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyzk!1AQa"q2$BRc#br %&'()*3456789:CDEFGHIJSTUVWXYZdefghijstuvwxyz?"" 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"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" endstream endobj 583 0 obj <>stream endstream endobj 529 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-10(\026\n\r\017 \224\025\016)-9.9(\026\r)10(\025\017\013)-20(\002\020\213\n\025\t\t\025\013)10.1(\025 )]TJ 0 -1 TD [(\016\n\t\202\005\025\024\017 \224\005\n\022\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 \002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\ \b\017\t\n\221 )]TJ T* [(\026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n \(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022\025\255\212\025\005\022\n\022\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 36.366 2 Td [(Antibacterial pr)31.1(e)10.9(v)12(ention of\022postcoagulation s)10(yndr)20(ome during )]TJ -2.695 -1 Td [(endoscopic r)31(emov)10(al of\022colon neoplasms \(r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.777 Tw 10 0 0 10 42.5197 724.8299 Tm (\024\006\036\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 I)Tj 0 Tw 5.83 0 0 5.83 163.901 728.1599 Tm (2)Tj 0.777 Tw 10 0 0 10 166.816 724.8299 Tm (-\021\036\f\021\026. \222\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.405 Tw -12.43 -1.218 Td (\027\026\004\017\n\024\005 \020\036\021\036\030\024\020\036\027\027\024\ \f\021\034 \f\004\017\021\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 0 Tw 5.83 0 0 5.83 222.3973 715.9819 Tm (2)Tj 0.405 Tw /Span<>> BDC 10 0 0 10 225.3123 712.6519 Tm ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (50%. )Tj 0.492 Tw -18.279 -1.218 Td (\222\021\026\021\017\f\021\017\004\036\f\022\031\033 \024\002\030\026\002\ \024\021\022\031 \007\026\027\027\t\b, \023\030\024\r\036\030\022\031 \030\ \017)Tj 0 Tw (-)Tj 0.484 Tw 0 -1.218 TD (\f\022\026 \f\n\036\013\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\036\027\017\036 \007\017\026\020\030\026\n\n\t \023\ \030\024\r\024)Tj 0 Tw (-)Tj 0.275 Tw T* (\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\026\n\n\036 R)13(ev)-16(iew Mana)-16.9(ger \(R)13(evMan\) 5.4.1 )]TJ 0 Tw T* [(\(Co)-16(chr)-33(ane coll)-15.9(abor)-33(a)15(t)-32(ion sof)-27.9(t)-32(w)-12(ar)-23.9(e\) \(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC (2\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 627.4059 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.717 Tw 10 0 0 10 42.5197 603.0499 Tm (\215\030\024\026\027\026\035\017\017\030\024\r\026\027\t \030\036\031\035\ \034\021\026\021\t \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\ \024 )Tj -0.056 Tw T* (\031\007\026\035\036\027\017\016 \220\023\017\021\036\035\017\026\035\034\ \027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (1055)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj -0.057 Tw T* (\006\017\036\027\021\024\r, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \020\036\021\036\030\024\020\036\027\027\024\f\021\ \017 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD (\007\024\r\026\027\017\005 I)Tj 0 Tw 5.83 0 0 5.83 84.0709 569.8458 Tm (2)Tj 0.069 Tw /Span<>> BDC 10 0 0 10 86.9859 566.5158 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (80% \023\024\035\031\004\036\027\t \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\036 )Tj 0.023 Tw -4.447 -1.218 Td (\030\026\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\017 \f\035\031\004\026\036\r \030\026\ \r\017\021\017\016 \023\024\f\021\022\024\026\020\031)Tj 0 Tw (-)Tj -0.025 Tw 0 -1.218 TD (\035\016\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \r\027\031\021\030\017\r\036\027\027\ \024\005 )Tj 0.182 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\017 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,30; 95% )Tj 0 Tw T* (\212\230: 0,09\2260,96, )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\) \(\217\017\f. 2\).)Tj 0.348 Tw T* [(\211\004\017\021\t\r\026\016, )0.6(\004\021\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\r\022\035\033\004\036\027\027\t\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 19.877 0 Td (\n\036\021\026)Tj 0 Tw (-)Tj 0.529 Tw -19.877 -1.218 Td [(\026\027\026\035\017 )0.6(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036, )0.6(\023\030\024\017\r\036\007\036\027\026 )0.6(\024\006\036\027\022\026 )]TJ 0.15 Tw T* (\022\026\004\036\f\021\r\026 \007\026\027\027\t\b \017\f\f\035\036\007\024\ \r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\017\f\021\036\n\t )Tj -0.063 Tw T* [(C)13(ONSOR)-12(T. \215\024)]TJ /Span<>> BDC ( )Tj EMC 5.354 0 Td [(\030\036\031\035\034\021\026\021\026\n )0.5(\024\006\036\027\022\017 \022\026\004\036\f\021\r\026 )0.5(\002\t\035\024 \r\t\016\r)]TJ 0 Tw (-)Tj 0.054 Tw -5.354 -1.218 Td (\035\036\027\024 \027\026\035\017\004\017\036 \017\f\f\035\036\007\024\r\ \026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \022\026\004\036\f\021\r\024\n, \004\021\024 )Tj -0.043 Tw T* (\016\r\035\016\036\021\f\016 \027\036\007\024\f\021\026\021\022\024\n \023\ \030\024\r\036\007\036\027\027\024\020\024 \n\036\021\026\026\027\026\035\ \017\026)Tj /Span<>> BDC ( )Tj EMC ([5].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 724.8299 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.103 Tw 10 0 0 10 274.9606 700.4739 Tm (\215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 \f\017\ \027\007\030\024\n \(\215\025\222\) \023\024\f\035\036 \220\027\007\024\f\ \022\024)Tj 0 Tw (-)Tj -0.077 Tw T* (\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \007\017\f\f\036\022\006\017\017 \016\r\035\016\036\021\f\016 \024\f\035\ \024\032\027\036)Tj 0 Tw (-)Tj 0.058 Tw T* (\027\017\036\n, \b\026\030\026\022\021\036\030\017\031\033\013\017\n\f\016\ \r\024\f\023\026\035\017\021\036\035\034\027\024\005 \030\036\026\022\006\ \017\036\005 )Tj 0.123 Tw T* (\024\030\020\026\027\017\n\026, \r\024\027\017\022\026\033\013\036\005\ \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\024\r\030\036\032\007\036\027\ \017\016 )Tj 0.139 Tw T* (\f\021\036\027\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017 \023\ \024\f\030\036\007\f\021\r\024\n \220\035\036\022\021\030\024\022\024\026\ \020\031\035\016)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\006\017\017 \r\024 \r\030\036\n\016 \r\t\023\024\035\027\036\027\017\016\ \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \023\024\007\f\ \035\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\017\f\021\024\005 \007\017\f\f\036\022\006\017\017.)Tj 1.155 Tw T* (\204\036\b\026\027\017\n \r\024\027\017\022\027\024\r\036\027\017\016 \ \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\024\020\024\ )Tj 0.028 Tw T* (\f\017\027\007\030\024\n\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\026 \027\036 \016\f\036\027, \017\n\036\036\021\f\016 \023\ \030\036\007\023\024\035\024\032\036\027\017\036, )Tj 0.194 Tw T* (\004\021\024 \021\036\030\n\017\004\036\f\022\024\036 \023\024\r\030\036\ \032\007\036\027\017\036 \n\t\001\036\004\027\024\005 \024\002\024\035\024\ \004\022\017 )Tj 0.066 Tw 0 -1.218 TD (\r\024 \r\030\036\n\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 \030\036\036\022\006\017\017 \f\035\017\017\f\021\024\005 \024\ \002\024)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD [(\035\024\004\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.479 0 Td [(\n\017\022\030\024\002\017\024\021\026 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017, )0.5(\r\024\007\036\005\f\021\r\031\033\013\026\016 )]TJ 0.431 Tw -3.479 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\005 \007\036\ \235\036\022\021 \017\020\030\026\033\021 \022\035\033\004\036\r\031\033\ )Tj 0 Tw T* (\030\024\035\034 [6].)Tj 0.226 Tw 0 -1.218 TD [(\215\025\222 \031\f\021\026\027\026\r\035\017\r\026\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 )0.5(\035\024\022\026\035\017\024\r\026\027\027\024\005 )]TJ -0.024 Tw 0 -1.218 TD (\002\024\035\036\027\036\027\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, \f\024\024\021\r\ \036\021\f\021\r\031\033\013\036\005 )Tj 0.38 Tw 0 -1.218 TD (\n\036\f\021\031 \r\t\023\024\035\027\036\027\017\016 \220\027\007\024\f\ \022\024\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\ \024\005 )Tj 0.057 Tw 0 -1.218 TD (\007\017\f\f\036\022\006\017\017, \017)Tj /Span<>> BDC ( )Tj EMC (\235\036\002\030\017\035\034\027\024\005 \035\017\b\024\030\026\007\022\017\ \017\035\017 \023\024\r\t\001\036\027\017)Tj 0 Tw (-)Tj 0.239 Tw T* (\036\n \r\024\f\023\026\035\017\021\036\035\034\027\t\b \n\026\030\022\036\ \030\024\r \022\030\024\r\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\005\022\024\006\017\021\024\r. )Tj 0.234 Tw 0 -1.218 TD (\222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \023\024\f\035\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\ \b \r\n\036)Tj 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\001\026\021\036\035\034\f\021\r \024\006\036\027\022\026 \002\024\035\036\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \023\030\024\017\ )Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\r\024\007\017\021\f\016 \027\036 \030\026\027\036\036 \004\036\n \004\036\ \030\036 6 \004\026\f\024\r \023\024\f\035\036 \024\022\024\027\004\026\ \027\017\016 )Tj ET q 42.52 212.149 379.842 206.357 re W n q /GS0 gs 379.8425035 0 0 206.3578966 42.5196838 212.1486647 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 9 0 0 9 42.5197 201.2362 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\032\027\021\031 \033\031\022\024\n\020 \021)Tj /Span<>> BDC ( )Tj EMC (\240\020\016\027 \030\020\025\025\013\200 MedLine)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( Search in the)Tj /Span<>> BDC ( )Tj EMC [(MedLine d)26.2(atabase)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.83 TD (\034\213 \217\003\004\003\r\005 \t\213\f\r\201\r\b\013 \240\004\b\b\013\ \r:)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 169.4649 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 105.1319 169.4649 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 136.313 169.4649 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 193.0059 169.4649 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 249.6988 169.4649 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 148.6457 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 314.8957 169.4649 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 380.0925 169.4649 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 148.6457 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 148.6457 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.7697 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 105.1319 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 136.313 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 193.0059 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 249.4488 148.3957 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 249.6988 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 148.3957 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 380.0925 148.3957 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 136.9265 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 136.9265 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 136.9265 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 136.9265 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 136.9265 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 136.9265 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 136.9265 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 125.4652 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 125.4652 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 125.4652 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 125.4652 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 125.4652 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 125.4652 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 125.4652 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 114.0039 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 114.0039 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 114.0039 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 114.0039 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 114.0039 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 114.0039 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 114.0039 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 102.5426 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 102.5426 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 102.5426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 102.5426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 102.5426 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 102.5426 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 102.5426 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 91.0814 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 91.0814 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 91.0814 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 91.0814 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 91.0814 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 91.0814 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 91.0814 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 79.6201 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 105.1319 79.6201 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 136.313 79.6201 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 79.6201 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 249.6988 79.6201 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 79.6201 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 380.0925 79.6201 cm 0 0 m 116.47 0 l S Q BT 0 0 0 1 k /GS1 gs /T1_4 1 Tf 8 0 0 8 63.7069 150.2957 Tm (\032\003\002\006)Tj 6.363 0 Td (\027\002\240)Tj 5.498 0.6 Td (\020\t\212)Tj -2.304 -1.2 Td (\t\217\217\f\r\240\002\004\b\t\235)Tj 9.391 1.2 Td (\020\t\212)Tj -1.35 -1.2 Td (\002\212\r\006\004\204\t\t)Tj 12.135 1.917 Td (\030\004\217\003\002\003\004)Tj -1.296 -1.2 Td (\006\004\213\t\003\t\235 \200\021\255)Tj 15.803 0.6 Td (\032\b\003\t\206\t\002\003\t\220)Tj -17.775 -2.034 Td (\032\224\241)Tj 8.15 0 Td (\032\224+)Tj /T1_1 1 Tf -36.876 -1.433 Td (Lee et al.)Tj 8.39 0 Td (2017)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.861 0 Td (ESD)Tj 6.032 0 Td (8/50)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 8.4 0 Td (1/50)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.547 0 Td (\202\n\023\017\006\017\035\017\027/\f\031\035\034\002\026\022\021\026\n)Tj -44.196 -1.433 Td (Shichijo et al.)Tj 8.39 0 Td (2021)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.861 0 Td (ESD)Tj 5.439 0 Td (14/188)Tj /Span<>> BDC ( )Tj EMC (\(7,5%\))Tj 8.4 0 Td (9/192)Tj /Span<>> BDC ( )Tj EMC (\(4,7%\))Tj 9.14 0 Td (\202\n\023\017\006\017\035\017\027/\f\031\035\034\002\026\022\021\026\n)Tj -44.196 -1.433 Td (Zhang et al.)Tj 8.39 0 Td (2015)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 6.54 0 Td (ESD)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (EMR)Tj 6.853 0 Td (45/107)Tj /Span<>> BDC ( )Tj EMC (\(42%\))Tj 8.307 0 Td (8/107)Tj /Span<>> BDC ( )Tj EMC (\(7,5%\))Tj 11.431 0 Td (\037\036\235\031\030\024\022\f\017\n)Tj -46.487 -1.433 Td (Shi et al.)Tj 8.39 0 Td (2016)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.774 0 Td (EMR)Tj 6.369 0 Td (2/38)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 8.15 0 Td (0/77)Tj /Span<>> BDC ( )Tj EMC (\(0%\))Tj 7.429 0 Td (\214\036\r\024\235\035\024\022\f\026\006\017\027, \006\036\235\021\026\017\ \007\017\n)Tj -43.078 -1.433 Td (Zheng et al.)Tj 8.39 0 Td (2022)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.774 0 Td (EMR)Tj 5.619 0 Td (13/126)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 8.15 0 Td (14/120)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 12.053 0 Td (\037\036\235\017\022\f\017\n)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 504.6022 56.0378 Tm (151)Tj ET endstream endobj 530 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;c   I-!1"AQUV25aqu#3BS&RT $%'()*46789:CDEFGHIJWXYZbcdefghijrstvwxyz⳴?iJR)JR)JT>vfڋYrKqjQSjz'y+=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNImwlչ:{ERTz8 Ҕ)JR)JR)JR)JR)JRiJR)JR)JUCo}J})JR)JR)JR#%D;&P.6Vpxcðk)JR*[{?[JR)JR)JR)JR)JR)@iJR)JR)JUCo}J})JRJNRDW0A UfX`(GzՕu|ԄU 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A)-12.6(n)-17.3(t)-46.2(i)-5.9(b)-17.7(a)-11.1(c)-41.5(t)-24.7(e)-12.1(r)-56.4(i)-5.1(a)-11.4(l p)-13.7(r)-19.1(e)-15.8(v)-18.7(e)-11.5(n)-17.3(t)-46.2(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-22.3(o)-15.8(s)-29.3(t)-22.4(c)-6.5(o)-18.2(a)-10.8(g)-9.5(u)-8.4(l)-37.8(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n s)-30.8(y)-27.5(n)-14.5(d)-10.4(r)-15.8(o)-9.2(m)-16.6(e)23( )]TJ 0.252 Tw -6.621 -1.2 Td [(d)-8.9(u)-7.6(r)-56.4(i)-3.2(n)-11.9(g )0.5(e)-11.5(n)-14.5(d)-11.1(o)-15.8(s)-17.7(c)-6.5(o)-8.3(p)-18.6(i)-5(c )0.5(r)-19.1(e)-11.5(m)-12.4(o)-10.3(v)-28.3(a)-11.4(l )0.5(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC 14.053 0 Td [(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n )0.5(n)-16.1(e)-21(o)-8.3(p)-20.1(l)-37.8(a)-26.6(s)-6.6(m)-11.6(s )0.5(\()39.2(r)-19.1(e)-15.8(v)-51.7(i)-11(e)-12.5(w )0.5(a)-7.6(n)-14.5(d )0.5(m)-16.6(e)-22.3(t)-36.8(a)-19.6(-)-13.1(a)-7.6(n)-7.8(a)-11.4(l)-8.3(y)-28.9(s)-26.1(i)-7.4(s)41.5(\))10.4(. )]TJ /T1_2 1 Tf 0.033 Tc -0.033 Tw 20.988 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_1 1 Tf 0.023 Tc 0.252 Tw 7.019 0 Td [( )0.5(2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)12.5(4)16.3(9)-22.6(\226)50.8(1)0.9(55)6.9(. )0.5(\()-0.9(i)-3.2(n )0.5(R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(.)23( )]TJ -0.023 Tw -42.061 -1.2 Td [(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.1(1)26.9(-)55.1(1)12.5(4)16.3(9)-23.6(-)55.1(1)0.9(55)]TJ /T1_0 1 Tf 0.01 Tc 0.046 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_2 1 Tf 0 Tc 0.051 Tw 10.632 0 Td ( \004\031\b\031\024\031\021 \001\022\n\031\f\020\235 \205\027\032\b\027\027\ \021\022\007, \214\216\221\210 \253\001\215\002\037 \n\031\f\031\033\032\ \031\n\023\031\f\031\b\022\022 \022\026\027\025\022 \003.\001.)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 )Tj 0.023 Tw -10.637 -1.2 Td (\003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: kolia\ .pogosov@yandex.ru)Tj /T1_0 1 Tf 0.01 Tc 0.169 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.174 Tw 14.353 0 Td [( Nik)13.1(olay S. P)15(ogosov)63(, Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology)42(, Salyama Adilya st., 2, )]TJ 0.023 Tw -14.358 -1.2 Td [(Moscow)52(,123423, R)22.1(ussia; e-mail: k)13(olia.pogosov@yande)-14.8(x.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 22.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 22.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 590.8719 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.146 Tw 10 0 0 10 70.8661 566.5159 Tm (\203\026\017\002\024\035\036\036 \004\026\f\021\t\n \024\f\035\024\032\027\ \036\027\017\036\n \023\024\f\035\036 \220\027\007\024\f\022\024\023\017\ \004\036)Tj 0 Tw (-)Tj 0.279 Tw 0 -1.218 TD (\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\ \022\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \220\023\017\021\036\035\017)Tj 0 Tw (-)Tj 0.26 Tw T* (\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005\ \021\024\035\f\021\024\005 \022\017\001\022\017 \030\026\n\036\030\024\ \n )Tj 0.085 Tw T* [(\002\024\035\036\036 )0.5(30 \n\n)]TJ /Span<>> BDC ( )Tj EMC [(\227 \016\r\035\016\036\021\f\016 )0.5(\023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 )0.6(\f\017\027\007)]TJ 0 Tw (-)Tj 0.363 Tw T* (\030\024\n \(\215\025\222\). \215\030\024\016\r\035\036\027\017\016 \007\ \026\027\027\024\020\024 \f\017\027\007\030\024\n\026 \f\b\024\032\017 )Tj 0.445 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \022\026\030\021\017\027\024\005\ \023\036\030\017\021\024\027\017\021\026, \r\t\r\026\027\027\024\020\024\ )Tj -0.017 Tw T* (\023\036\030\235\024\030\026\006\017\036\005 \023\024\035\024\020\024 \024\ \030\020\026\027\026, \004\021\024 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\017\033 \027\036\024\002\024\f\027\024\r\026\027\027\t\b \007\017\026\ \020\027\024\f\021\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\ \027\017\005 )Tj 0.142 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\033 \026\022\021\017\r\027\024\005 \035\ \036\004\036\002\027\024\005 \021\026\022\021\017\022\017, \r\022\035\033\ \004\026)Tj 0 Tw (-)Tj 0.151 Tw T* [(\033\013\036\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.578 0 Td [(\f\036\002\016 )0.5(\r\t\023\024\035\027\036\027\017\036 )0.6(\023\024\035\024\f\021\027\t\b )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\b )]TJ 0 Tw -3.578 -1.218 Td (\r\n\036\001\026\021\036\035\034\f\021\r [1].)Tj 0.386 Tw T* (\222\024\020\035\026\f\027\024 \026\027\026\035\017\031 \030\036\031\035\ \034\021\026\021\024\r 1000 \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.226 Tw T* (\f\022\017\b \007\017\f\f\036\022\006\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \215\025\222 \030\ \026\r\017\035)Tj 0 Tw (-)Tj 0.183 Tw T* (\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (13,6%)Tj /Span<>> BDC ( )Tj EMC ([2]. \204\036\007\017\026\027\027\024\036 \022\024\035\017\004\036\f\021\ \r\024 \022\024\005\022\024-\007\027\036\005, )Tj 0.264 Tw T* (\023\030\024\r\036\007\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \220\027\007\024)Tj 0 Tw (-)Tj 0.469 Tw T* (\f\022\024\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\ \024\005 \007\017\f\f\036\022\006\017\017, \f\024\f\021\026\r\035\016\036\ \021 )Tj 0.189 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005, \024\007\027\026\022\024 \023\030\024\016\r\035\036\027\ \017\016 \215\025\222 \023\030\017\r\024\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017)Tj 0 Tw (-)Tj 0.199 Tw T* (\004\036\027\017\033 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\017 \020\024\f\023\017\021\026\035\017\026\006\017\017 \023\026\ \006\017\036\027)Tj 0 Tw (-)Tj 0.091 Tw T* (\021\026, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \007\027\016, \004\021\024 \023\024\r\t\001\026\036\021 \f\021\024\017\ \n\024\f\021\034 \036\020\024 )Tj 0 Tw T* (\035\036\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([3].)Tj 0.03 Tc 0.019 Tw T* [(\200 )0.5(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )0.5(\024\021\f\031\021\f\021\r\031\036\021 )0.5(\036\007\017\027\026\016 )0.5(\022\024\027\006\036\023\006\017\016)30( )]TJ 0.033 Tw T* (\023\026\021\024\020\036\027\036\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\235\017\035\026\022\021\017\022\017 \007\026\027\027\024\020\ \024 \024\f\035\024\032\027\036\027\017\016.)30( )]TJ 0.037 Tw T* [(\213\007\017\027\f\021\r\036\027\027\t\n \017\r\036\f\021\027\t\n \n\036\ \021\024\007\024\n \b\017\030\031\030\020\017\004\036\f\022\024\005)30( )]TJ 0.134 Tw T* (\023\030\024\235\017\035\026\022\021\017\022\017 \016\r\035\016\036\021\f\ \016 \022\035\017\023\017\030\024\r\026\027\017\036 \023\024\f\035\036\024\ \023\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.152 Tw T* (\030\026\006\017\024\027\027\024\020\024 \007\036\235\036\022\021\026, \r\ \n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\036\n, \023\030\024\r\036\007\036\027\027\t\005)30( )]TJ 0.195 Tw T* [(L)-32(iu \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \n\036\021\026\026\027\026\035\017, \r\022\035\033\004\ \026\r\001\017\005 477 \023\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.309 Tw T* (\036\027\021\024\r, \027\036 \r\t\016\r\017\035 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\024\005 \030\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.38 Tw T* (\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036 \030\026\r\017\021\017\016 \023\024\f\021\022\ \024\026\020\031\035\016\006\017\024\027\027\024\020\024)30( )]TJ 0.271 Tw T* (\f\017\027\007\030\024\n\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \020\030\031\023\023 \f)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.18 Tw T* (\f\022\017\n \022\035\017\023\017\030\024\r\026\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\020\024 \210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,75 95%)30( )]TJ 0.022 Tw T* [(\212\230: )0.5(\(0,26\2262,18\), )]TJ /T1_2 1 Tf 0 Tc 0 Tw (p)Tj /T1_1 1 Tf 0.03 Tc 0.022 Tw /Span<>> BDC 7.896 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.099 0 Td [(0,6 )0.5([4]. \211\004\017\021\t\r\026\016, \004\021\024 )0.5(\007\026\027\027\t\005)30( )]TJ 0.186 Tw -8.995 -1.218 Td [(\f\017\027\007\030\024\n \f\024\023\030\024\r\024\032\007\026\036\021\f\016\ \023\030\017\027\026\022\026\n\017 \f\017\f\021\036\n\027\024\005)30( )]TJ 0.051 Tw T* [(\r\024\f\023\026\035\017\021\036\035\034\027\024\005 )0.5(\030\036\026\022\006\017\036\005 )0.5(\024\030\020\026\027\017\n\026, )0.5(\023\030\036\007\023\030\017\027\017)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.19 Tw T* (\n\026\035\017\f\034 \023\024\023\t\021\022\017 \023\030\024\r\036\007\036\ \027\017\016 \026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\ \017)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.13 Tw T* [(\035\026\022\021\017\022\017 )0.6(\007\026\027\027\024\020\024 )0.5(\f\017\027\007\030\024\n\026. )0.5(\210\007\027\026\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.241 0 Td [(\035\017\021\036\030\026\021\031\030\036)30.1( )]TJ 0.364 Tw -17.241 -1.218 Td [(\017\n\036\033\021\f\016 )0.5(\023\030\024\021\017\r\024\030\036\004\017\r\t\036 )0.5(\007\026\027\027\t\036 )0.5(\024\021\027\024\f\017\021\036\035\034\027\024)30( )]TJ 0.495 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 \023\030\024\235\017\035\ \026\022\021\017\004\036\f\022\024\020\024 \027\026\027\026\004\036\027\ \017\016)30( )]TJ 0.704 Tw T* [(\026\027\021\017\002\017\024\021\017\022\024\r )0.5(\023\036\030\036\007 )0.5(\r\t\023\024\035\027\036\027\017\036\n )0.5(\007\017\f\f\036\022\006\017\017)30( )]TJ 0.079 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036. \215\030\017\027\ \017\n\026\016 \r\024 \r\027\017\n\026\027\017\036 \007\024)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.482 Tw T* [(\f\021\026\021\024\004\027\024\036 \022\024\035\017\004\036\f\021\r\024 \ \017\f\f\035\036\007\024\r\026\027\017\005, \023\030\024\r\036\007\036\027\ )30( )]TJ 0 Tw T* (\n\036\021\026\026\027\026\035\017 \007\026\027\027\t\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 590.8719 Tm [(\207)21(\026)45(\024\034\033\031\026)-10(\r\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.178 Tw 10 0 0 10 303.3071 566.5159 Tm (\204\036\021\026\026\027\026\035\017 \r\t\023\024\035\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026)Tj 0 Tw (-)Tj 0.171 Tw T* [(\006\017\016\n\017 )0.6(\253T)47(he )0.6(p)25(r)-24(efer)-24(r)-23.9(ed )0.6(r)-24(epor)-22(t)-32(ing )0.6(i)-24(tems )0.6(for )0.6(sy)-13(stema)15.1(t)-32(ic )]TJ 0.163 Tw T* [(r)-24(ev)-15.9(iews )0.5(and me)-11.9(t)15(a-anal)35(y)-13(ses )0.5(\(PRISMA\)\273. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 17.372 0 Td (\n\036\021\026\026\027\026\035\017 )Tj 0.486 Tw -17.372 -1.218 Td (\r\022\035\033\004\036\027\t \023\024\035\027\024\021\036\022\f\021\024\r\ \t\036 \f\021\026\021\034\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n )Tj 0.271 Tw T* (\016\t\022\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\021\030\026\032\036\027\024 \030\026\r\017\ \021\017\036 \023\024\f\021\022\024\026\020\031\035\016)Tj 0 Tw (-)Tj 0.196 Tw T* (\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\024\f\ \035\036 \031\007\026\035\036\027\017\016 \220\023\017\021\036\035\017\026\ \035\034\027\t\b )Tj -0.007 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\ \024\005 \022\017\001\022\017 \023\031\021\036\n \220\027\007\024\f\022\024\ \023\017\004\036)Tj 0 Tw (-)Tj 0.002 Tw T* (\f\022\024\005 \007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\036.)Tj 0.014 Tw T* [(\200 )0.5(\030\036\031\035\034\021\026\021\036 )0.5(\023\024\017\f\022\026 \r)]TJ /Span<>> BDC ( )Tj EMC 9.332 0 Td [(\002\026\036 )0.5(\007\026\027\027\t\b )0.5(P)20(ubMed \023\024)]TJ /Span<>> BDC ( )Tj EMC 10.033 0 Td (\026\023\030\024)Tj 0 Tw (-)Tj -0.027 Tw -19.365 -1.218 Td [(\f\031 \253end)-16(oscopic submucosal dissec)-16(t)-32(ion\273 \017)]TJ /Span<>> BDC ( )Tj EMC [(\253coa)-17(gul)-15.9(a)15(t)-32(ion )]TJ 0.204 Tw T* [(syndr)-32(ome\273 )0.5(\002\t\035\024 \027\026\005\007\036\027\024 )0.5(58 \017\f\f\035\036\007\024\r\026\027\017\005. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\b\024\007\036 )Tj 0.029 Tw T* (\023\030\024\r\036\007\036\027\017\016 \f\022\030\017\027\017\027\020\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\b \030\026\002\024\021 \r\t\007\036\035\036\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.055 Tw T* (50. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \017\f\022\035\033\004\036\027\t \ 48 \023\031\002\035\017\022\026\006\017\005, \023\024\f\r\016)Tj 0 Tw (-)Tj 0.056 Tw T* [(\013\036\027\027\t\b )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n\031 )0.5(\031\007\026\035\036\027\017\033 )0.5(\220\023\017\021\036\035\017\026\035\034\027\t\b )]TJ -0.029 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\ \024\005 \022\017\001\022\017, \021\036\b\027\017\004\036\f\022\017\n \026\ \f\023\036\022)Tj 0 Tw (-)Tj -0.002 Tw T* (\021\026\n \r\t\023\024\035\027\036\027\017\016 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \007\017\f)Tj 0 Tw (-)Tj 0.049 Tw T* (\f\036\022\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \235\026\022\021\024\030\026\n \030\017\f\022\026 \030\ \026\r\017\021\017\016 \215\025\222 \023\024\f\035\036 )Tj 0.237 Tw T* [(\036\036 )0.5(\r\t\023\024\035\027\036\027\017\016. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 8.229 0 Td [(\030\036\031\035\034\021\026\021\036 )0.6(\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 )0.6(\023\024)]TJ 0 Tw (-)Tj 0.278 Tw -8.229 -1.218 Td (\017\f\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\017\002\035\017\024\020\030\026\235\017\004\036\f\022\017\n \007\026\ \027\027\t\n, \f\030\036\007\017 \r\022\035\033)Tj 0 Tw (-)Tj 0.163 Tw T* (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \017\f\f\035\036\007\024\r\026\027\017\ \005 \002\t\035\024 \r\t\016\r\035\036\027\024 )Tj 0.363 Tw T* [(\007\024\023\024\035\027\017\021\036\035\034\027\024 )0.5(3)]TJ /Span<>> BDC ( )Tj EMC [(\023\031\002\035\017\022\026\006\017\017, )0.5(\023\024\f\r\016\013\036\027\027\t\036 )0.5(\026\027\021\017)]TJ 0 Tw (-)Tj 0.303 Tw T* (\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\030\024\235\017\ \035\026\022\021\017\022\036 \023\024\f\021\022\024\026\020\031\035\016\006\ \017\024\027\027\024\020\024 )Tj 0.01 Tw T* (\f\017\027\007\030\024\n\026 \023\024\f\035\036 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\024\020\024 \031\007\026\035\036\027\017\016 \027\ \024\r\024\024\002)Tj 0 Tw (-)Tj 0.059 Tw T* (\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005 \022\017\001\022\ \017. \221\026\022\017\n \024\002\030\026\024\n, \r\022\035\033\004\036\ \027\024 )Tj 0 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.302 Tw T* (\215\030\017 \023\024\017\f\022\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\002\026\036 \007\026\027\027\t\b eL)-32(ibr)-33(ar)-24(y \035\017\021\036\030\026\021\031\030\027\t\b )]TJ 0.164 Tw T* (\017\f\021\024\004\027\017\022\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\026\023\030\024\f\031 \253\023\024\f\021\022\024\026\020\031\035\016\006\ \017\024\027\027\t\005 )0.5(\f\017\027\007)]TJ 0 Tw (-)Tj 0.069 Tw T* (\030\024\n\273 \027\036 \027\026\005\007\036\027\024 \027\017 \024\007\027\ \024\005 \f\021\026\021\034\017, \022\024\021\024\030\026\016 \024\f\r\036\ \013\026\036\021 )Tj 0.257 Tw T* (\023\030\024\002\035\036\n\031 \030\026\r\017\021\017\016 \023\024\f\021\ \022\024\026\020\031\035\016\006\017\024\027\027\024\020\024 \f\017\027\007\ \030\024\n\026 )Tj 0.481 Tw T* [(\023\024\f\035\036 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 )0.7(\031\007\026\035\036\027\017\016 )0.5(\027\024\r\024\024\002\030\026\024\r\026)]TJ 0 Tw (-)Tj 0.143 Tw T* (\027\017\005 \021\024\035\f\021\024\005 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \036\020\024 \026\027\021\017\002\026\022\021\036\030\ \017\026\035\034\027\024\005 )Tj 0 Tw T* (\023\030\024\235\017\035\026\022\021\017\022\017.)Tj /T1_0 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.303 Tw 0 -1.218 TD (\222\031\n\n\026\030\027\024\036 \027\026\004\036\027\017\036 \007\017\b\ \024\021\024\n\017\004\036\f\022\017\b \007\026\027\027\t\b \024\023\017\ )Tj 0 Tw (-)Tj 0.088 Tw T* (\f\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \024\021\027\024\001\036\027\017\016 \001\026\027\f\024\r\ \(\210\231\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017)Tj 0 Tw (-)Tj 0.103 Tw T* (\021\036\035\034\027\t\n \017\027\021\036\030\r\026\035\024\n \(\212\230\ \). \210\231 \030\026\f\f\004\017\021\t\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.483 Tw T* [(\021\024\007\031 )0.5(Mantel\226Haenszel. )0.6(\212\035\016 )0.6(\n\036\021\026\026\027\026\035\017\026 )0.6(\r\024 \r\f\036\b )]TJ 0.141 Tw T* (\f\035\031\004\026\016\b \017\f\023\024\035\034\024\r\026\035\017 \n\024\ \007\036\035\034 \f\035\031\004\026\005\027\t\b \220\235\235\036\022\021\ \024\r. )Tj 0.126 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\031\033 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034 \f\030\036\007\017 \017\f\f\035\036\007\ \024\r\026\027\017\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7153 56.0378 Tm (150)Tj ET endstream endobj 615 0 obj [619 0 R] endobj 616 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-10(\026\n\r\017 \224\025\016)-9.9(\026\r)10(\025\017\013)-20(\002\020\213\n\025\t\t\025\013)10.1(\025 )]TJ 0 -1 TD [(\016\n\t\202\005\025\024\017 \224\005\n\022\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 \002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\ \b\017\t\n\221 )]TJ T* [(\026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n \(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022\025\255\212\025\005\022\n\022\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 36.366 2 Td [(Antibacterial pr)31.1(e)10.9(v)12(ention of\022postcoagulation s)10(yndr)20(ome during )]TJ -2.695 -1 Td [(endoscopic r)31(emov)10(al of\022colon neoplasms \(r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 388.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 388.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 351.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 351.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-149-155)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 131.3031 695.3259 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-9.9(\026\n\r\017 )]TJ -3.998 -1.105 Td [(\224\025\016)-10(\026\r)10(\025\017\013)-19.9(\002\020\213\n\025\t\t\025\013)10(\025 \016\n\t\202\005\025\024\017 \224\005\n\022)-23.3(\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 )]TJ 2.223 -1.105 Td [(\002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\b\017\t\n\ \221 \026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n )]TJ 0 Tw 1.413 -1.105 Td [(\(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022)-23.3(\025\255\212\025\005\022)-23.3(\n\022)-23.2(\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 607.822 Tm [(\034\025\013)10(\025\016\025\b\022)-23.2(\007.\001.)]TJ 8.162 0 0 8.162 118.8231 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 123.459 607.822 Tm [(, \006\017\020\r\017\005\025\b\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 217.4055 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 222.0415 607.822 Tm [(, \035\n\r\002)-20(\026)11.1(\025\b\022)-23.3(\f)-31(.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 307.938 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 319.2587 607.822 Tm (, \007\017\212\017\005\025\b \030.\021.)Tj 0 Tw 8.162 0 0 8.162 406.4297 612.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 593.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 590.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 569.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 566.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 9 0 0 9 90.7087 547.6488 Tm (\037\036\035\034: \022\016\r\007\022\023\017 \204\203\203\027\n\023\022\021\ \025\031\024\023\017 \020\025\023\022\240\022\031\023\022\n\031\023\027\032\ \020\033\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\203\022\f\020\n\023\022\n\027 \033\031\024\023\n\031\020\b\r\ \f\t\006\022\031\025\025\031\b\031 \024\022\025\030\032\031\026\020.)Tj 0.01 Tw 0 -1.111 TD (\215\003\036\206\002\003\035\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \033\031\022\024\n \f\022\023\027\032\020\023\r\032\ \013 \022)Tj /Span<>> BDC ( )Tj EMC (\026\027\023\020\020\025\020\f\022\016 \033\032\031\022\016\021\031\030\022\ \f\024\t \021)Tj /Span<>> BDC ( )Tj EMC (\024\031\031\023\021\027\023\024\023\021\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\032\027\n\031\026\027\025\030\020\006\022\t\026\022 )Tj -0.022 Tw T* (PRISMA \033\032\022)Tj /Span<>> BDC ( )Tj EMC [(\033\031\026\031\212\022 \033\031\022\024\n\031\021\031\235 )0.5(\024\022\024\023\027\026\013 PUBMED \021)]TJ /Span<>> BDC ( )Tj EMC [(\204\f\027\n\023\032\031\025\025\031\235 )0.5(\240\020\016\027 Medline \240\027\016 \031\b\032\020\025\022\007\027\025\ \022\t \030\020\023\013 \033\r\240\f\022\n\020)]TJ 0 Tw (-)Tj 0.03 Tw T* (\006\022\022 \024\032\027\030\022 \020\025\b\f\031\t\016\013\007\025\031\ \235 \f\022\023\027\032\020\023\r\032\013. \211)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\023\027\026\020\023\022\007\027\024\n\022\235 \031\240\016\031\ \032 \021\n\f\005\007\027\025\013 \021\024\027 \022\024\024\f\027\030\031\ \021\020\025\022\t, \033\031\024\021\t\212\027\025\025\013\027 )Tj 0.059 Tw T* (\020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\031\235 \033\032\ \031\203\022\f\020\n\023\022\n\027 \033\031\024\023\n\031\020\b\r\f\t\006\ \022\031\025\025\031\b\031 \024\022\025\030\032\031\026\020 \033\031\024\ \f\027 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\b\031 \r\030\ \020\f\027\025\022\t \204\033\022)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\023\027\f\022\020\f\017\025\013\200 \025\031\021\031\031\240\032\020\016\ \031\021\020\025\022\235 \023\031\f\024\023\031\235 \n\022\213\n\022.)Tj 0.147 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\022\016 \021\n\f\005\007\027\025\013 5 \022\024\024\f\027\ \030\031\021\020\025\022\235)Tj /Span<>> BDC ( )Tj EMC (\227 1055 \033\020\006\022\027\025\023\031\021, 546)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \020\025\023\022\240\022\031\023\022\n\031\033\032\031\ )Tj 0 Tw (-)Tj 0.147 Tw T* (\203\022\f\020\n\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (509)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \240\027\016 \025\027\027. \004\031\024\023\n\031\020\ \b\r\f\t\006\022\031\025\025\013\235 \024\022\025\030\032\031\026 \016\025\ \020\007\022\026\031 \007\020\212\027 \032\020\016\021\022\021\020\f\024\ \t \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 )Tj -0.025 Tw T* (\033\020\006\022\027\025\023\031\021 \240\027\016 \020\025\023\022\240\020\ \n\023\027\032\022\020\f\017\025\031\235 \033\032\031\203\022\f\020\n\023\ \022\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\027\025\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\031\235 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \030\020\025\025\031\ \b\031 \026\027\023\031\030\020 )Tj 0.023 Tw T* (\033\032\031\203\022\f\020\n\023\022\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 16,1% \033\032\031\023\022\021 5,9% \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,30; 95% \220\002: 0,09\2310,96; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\).)Tj 0.215 Tw T* (\207\003\202\035\224\232\036\001\002\036: \020\025\023\022\240\022\031\023\ \022\n\031\033\032\031\203\022\f\020\n\023\022\n\020 \024\025\022\255\020\ \027\023 \007\020\024\023\031\023\r \032\020\016\021\022\023\022\t \033\031\ \024\023\n\031\020\b\r\f\t\006\022\031\025\025\031\b\031 \024\022\025\030\ \032\031\026\020 )Tj 0.023 Tw T* (\033\031\024\f\027 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\b\ \031 \r\030\020\f\027\025\022\t \204\033\022\023\027\f\022\020\f\017\025\ \013\200 \025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\ \031\f\024\023\031\235 \n\022\213\n\022.)Tj /T1_2 1 Tf 0.01 Tc 0.225 Tw 8 0 0 8 42.5596 422.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.23 Tw 8.7 0 Td ( \033\031\024\023\n\031\020\b\r\f\t\006\022\031\025\025\013\235 \024\022\ \025\030\032\031\026, \020\025\023\022\240\020\n\023\027\032\022\020\f\017\ \025\020\t \033\032\031\203\022\f\020\n\023\022\n\020, \204\025\030\031\024\ \n\031\033\022\007\027\024\n\031\027 \r\030\020\f\027\025\022\027 \204\033\ \022\023\027\f\022\020\f\017\025\013\200 )Tj 0.023 Tw -8.705 -1.2 Td (\025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\031\f\024\ \023\031\235 \n\022\213\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.021 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.8( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.011 Tc -0.035 Tw 8.94 0 Td ( \215\024\020\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\222., \207\026\035\022\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\202., \203\026\026\030\024\r \230.\200. \202\027\021\017\002\026\022\ \021\036\030\017\026\035\034\027\026\016 \023\030\024\235\017\035\026\022\ \021\017\022\026 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\ \027\024\020\024)11( )]TJ 0.02 Tc -8.945 -1.2 Td (\f\017\027\007\030\024\n\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n \031\007\026\035\036\ \027\017\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\ \035\f\021\024\005 \022\017\001\022\017 \(\035\017\021\036\030\026\021\031\ \030\027\t\005 \024\002\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_1 1 Tf -0.02 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (149\226155. https://doi.org/10.33878/2073-7556-2026-25-1-149-155)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 114.0002 326.0332 Tm [(Antibacterial pr)31(e)11(v)12(ention of\022)-23.3(postcoagulation )]TJ -0.592 -1.111 Td [(s)10(yndr)20(ome during endoscopic r)31(emov)10(al of\022)-23.3(colon )]TJ 1.6 -1.111 Td [(neoplasms \(r)31(e)11(vie)11(w and meta-analy)10.1(sis\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 261.5293 Tm [(Nik)11(olay\022)-23.2(S.\022)-23.3(P)10(ogosov)]TJ 8.162 0 0 8.162 152.3006 266.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 156.9366 261.5293 Tm [(, Ar)-20(tem\022)-23.2(A)-31(.\022)-23.3(Balkar)20.1(ov)]TJ 0 Tw 8.162 0 0 8.162 268.9607 266.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 273.5966 261.5293 Tm [(, Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(Lik)11(utov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 379.5451 266.1913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 390.8658 261.5293 Tm [(, Ily)21(a V)61.9(. Na)20(z)15(ar)20(ov)]TJ 0 Tw 8.162 0 0 8.162 487.393 266.1913 Tm (1)Tj 5.83 0 0 5.83 42.5197 247.19 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 243.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 235.19 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 231.86 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf 0.143 Tw 9 0 0 9 90.7087 201.3561 Tm [(A\237IM: to assess ef)-40(f)-43(icacy of antibacter)-37(ial p)46(rev)13(ention for postcoagulation syndrome af)-46(ter endoscopic remov)16(al of )]TJ 0.023 Tw T* [(colon neoplas)33(ms.)]TJ -0.014 Tc -0.033 Tw T* [(MA)45(TERIAL)-28(S )0.5(A)53(ND METHODS: )0.5(literature )0.5(search )0.5(and )0.5(meta-analysis )0.5(w)12(ere per)-34(for)-14(med )0.5(in )0.5(accord)26(ance )0.5(with )0.5(the P)66(RISMA )0.5(guidelines)-14( )]TJ 0.016 Tw T* [(using the PUBMED search system in the Medline electronic d)26(atabase. The systematic revie)10(w included all studies dev)13(o)12.9(ted)-14( )]TJ 0.023 Tw T* [(to antibacter)-37(ial p)46(roph)12(ylactic of postcoagulation syndrome af)-46(ter endoscopic submucosal resection neoplas)32.9(ms of colon.)]TJ 0 Tc 0.065 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the analysis )0.5(included 5 studies)]TJ /Span<>> BDC ( )Tj EMC [(\227 1055 patients, 546 in the antibio)13(tic p)46.1(rev)12.9(ention g)14(roup and 509 in the )]TJ 0.099 Tw 0 -1.111 TD [(g)14(roup without it. P)15(ostcoagulation syndrome w)13(as low)12(er in antibacter)-36.9(ial p)46(roph)12(ylaxis g)13.9(roup 5,9% vs 16,1% without )]TJ 0.023 Tw T* [(antibacter)-36.9(ial p)46(rev)13(ention g)14(roup \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.30; 95% CI: 0,09\2310,96; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.04\).)Tj 0.071 Tw T* [(C)21(ON)22(CLUSION: )0.6(antibio)13.1(tic )0.5(p)46(roph)12(ylactic )0.6(reduces )0.6(the )0.6(incidence )0.6(of )0.5(postcoagulation )0.6(syndrome )0.6(af)-46(ter )0.5(endoscopic )0.5(remov)16(al )]TJ 0.023 Tw T* [(of epithelial neoplas)33.1(ms of the colon.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 96.0869 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( postcoagulation syndrome, antibacter)-36.9(ial p)46(roph)12(ylactic, endoscopic remov)16(al of)]TJ /Span<>> BDC ( )Tj EMC [(epithelial neoplas)33(ms of)]TJ /Span<>> BDC ( )Tj EMC (the colon)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 556.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 547.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 209.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 200.9331 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5895 837.3533 Tm [(\213\207)-21(\r)41(\037\037\t\037)-19.9(\b\006\215)]TJ /T1_0 1 Tf 0 -1.605 TD [(MET)30(A)5(\243)5(ANAL)30(Y)30(SIS)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.5896 56.0378 Tm (149)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 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P)35(r)-37(inc)-24(iples of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical )]TJ 0.072 Tw -1.296 -1.25 Td [(car)-24(e for r)-24(ec)-15.9(t)15(al w)-14(ounds. )]TJ /T1_1 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC [(the N)18(ational Medical and Surgical )]TJ 0.023 Tw T* [(Center named af)-46(ter N.I.)]TJ /Span<>> BDC ( )Tj EMC (Pirogov.)Tj /T1_0 1 Tf ( 2024;19\(2\):52\22657. \(In Russ.\).)Tj -0.006 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)50(r)-33(ansi)-24(t)-31.9(ions)]TJ /Span<>> BDC ( )Tj EMC (S.N., Onnintsev)Tj /Span<>> BDC ( )Tj EMC [(I.E., K)25(ozl)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(N.S., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Ana)15(t)17(omical )]TJ 0.06 Tw -1.796 -1.25 Td [(and sur)-32(gical stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ef)-55.9(f)-28(ic)-24(iency and safe)-12(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(per)-37(ineal dr)-32.9(aina)-17(ge )]TJ -0.029 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic cell)35(ul)-16(ar sp)32(a)-17(ces in r)-24(ec)-16(t)15(al w)-14(ounds. )]TJ /T1_1 1 Tf 0 Tw [(P)15(olytrauma)]TJ /T1_0 1 Tf -0.029 Tw (. 2025;2:77\22688. )Tj 0.023 Tw T* [(\(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1819-1495-2025-2-88-88)Tj /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ 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of\022th)11(e )]TJ -0.724 -1 Td [(e)21(xtr)21(aperitoneal par)-19.9(t of\022th)11(e r)31(ectum complicated b)10(y F)15(ournier\236)63(s gangr)31(ene)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.185 Tw 10 0 0 10 42.5197 724.8299 Tm [(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.5(\026\021\030\031\007\027\036\027\026 )0.6(\024\f\024\002\036\027\027\024\f\021\016\n\017 )]TJ 0 Tw 0 -1.218 TD (\024\002\036\f\023\036\004\036\027\017\016 \023\030\036\036\n\f\021\r\036\ \027\027\024\f\021\017 \n\036\032\007\031 \220\021\026\023\026\n\017.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\031\002\212\002\f\b\t\003\r\f\001\b\004\235 \t\b\226\002\006\214\004\204\ \t\235)Tj 0.295 Tw 0 -1.218 TD (\255\017\027\035\032\255\034\036 \200\032\037\034\036\025\020\032:)Tj /T1_1 1 Tf ( \215\026\006\017\036\027\021 \007\024\002\030\024\r\024\035\034\027\024\ \023\024\007)Tj 0 Tw (-)Tj 0.34 Tw T* (\023\017\f\026\035 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\036\ \f\024\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\033 )Tj 0.214 Tw 0 -1.218 TD (\023\036\030\f\024\027\026\035\034\027\024\005 \n\036\007\017\006\017\027\ \f\022\024\005 \017\027\235\024\030\n\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\035\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\027\027\024\005 \235\024\030\n\036.)Tj /T1_2 1 Tf T* (\224\035\032\027\017\031\032\022\025\017\255\020\205: )Tj /T1_1 1 Tf 0.903 Tw 8.709 0 Td (\025\024\035\035\036\022\021\017\r \026\r\021\024\030\024\r \r\t\030\026\ \032\026)Tj 0 Tw (-)Tj 0.402 Tw -8.709 -1.218 Td (\036\021 \002\035\026\020\024\007\026\030\027\024\f\021\034 \215\026\027\ \024\r\031 \200\016\004\036\f\035\026\r\031 \200\026\f\017\035\034\036\r\ \017\004\031, )Tj 0.007 Tw T* [(\222\024\020\024\n\024\027\016\027\031 \025\026\023\030\036\035\031 \216\ \026\004\026\021\031\030\024\r\017\004\031, )0.5(\214\031\002\036\027\006\031 \200\026\f\017\035\017\033 )]TJ 0.543 Tw T* [(\202\035\036\022\f\026\027\007\030\024\r\017\004\031, )0.6(\217\016\007\027\024\r\031 )0.5(\202\027\007\030\017\026\027\031 )0.5(\202\035\036\022\f\036\036\r\017\004\031, )]TJ -0.011 Tw 0 -1.218 TD [(\215\017\013\026\035\034\027\017\022\024\r\024\005 )0.5(\224\035\017\017 \210\035\036\020\024\r\027\036, \212\017\007\026\b\026\ \027\024\r\031 \202\030\f\036\027\031 )]TJ -0.08 Tw 0 -1.218 TD [(\025\026\002\036\022\024\r\017\004\031, \207\017\007\032\017\036\r\024\005\ )0.5(\202\035\017\027\036 \230\f\n\026\017\035\024\r\027\036, \025\024\030\032\ \031\022\031 )]TJ 0 Tw 0 -1.218 TD (\204\017\b\026\017\035\031 \222\036\030\020\036\036\r\017\004\031)Tj /T1_2 1 Tf T* [(GRA)28(T)-23(ITUDE: )]TJ /T1_1 1 Tf 0.144 Tw 5.35 0 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC (team of)Tj /Span<>> BDC ( )Tj EMC [(aut)-13(hor)-10(s e)-18(xp)25(r)-24(esses i)-24(ts gr)-33(a)15(t)-32(i)]TJ 0 Tw (-)Tj 0.191 Tw -5.35 -1.218 Td [(tude t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(V)-16(y)22(a)-17(chesl)-16(av V. P)40(anov, K)-15.9(ap)25(r)-24(el)]TJ /Span<>> BDC ( )Tj EMC (K.)Tj /Span<>> BDC ( )Tj EMC [(S)-16(o)-16(gomony)22(an, )]TJ 1.373 Tw T* [(V)25(asil)35(y)]TJ /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(L)35(ubents, Andr)-36.9(ian A. R)-19.9(y)22(adnov, )]TJ 0.705 Tw T* [(Y)35(ul)-31(ia)]TJ /Span<>> BDC ( )Tj EMC (O.)Tj /Span<>> BDC ( )Tj EMC [(P)-24(ishchalnikov)-14.9(a, Ar)-10(sen K. Dzid)42(akhanov, )]TJ 0 Tw T* [(Al)-31(ina)]TJ /Span<>> BDC ( )Tj EMC (I.)Tj /Span<>> BDC ( )Tj EMC [(Bid)17.1(zhiev)-14.9(a, Mikhail S.)]TJ /Span<>> BDC ( )Tj EMC [(K)25.1(or)-24(zhuk)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.522 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-5.9(\017)-5.5(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \205)27.6(\r)-4.3(\032\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.024 Tc 0.024 Tw T* [(\036\024)-14.2(\027)-44.6(\f)-20.7(\027)-17.4(\021)-18.5(\022)-4.6(\007)]TJ /Span<>> BDC 3.617 0 Td ( )Tj EMC [(\206)69.9(.)4.5(\211.)]TJ /T1_1 1 Tf 0 Tc 0.742 Tw -3.617 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.029 Tc 0.771 Tw [( \205)-21.2(\020)-27.3(\026)-25(\031)-26.2(\200)-21.6(\022)-21.8(\025)]TJ /Span<>> BDC 19.281 0 Td ( )Tj EMC [(\217)-1.4(.\002.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -19.281 -1.218 Td [(\003)-27.3(\f\022)-5.3(\026)-6(\031\021)]TJ /Span<>> BDC 3.021 0 Td ( )Tj EMC [(\004)19.3(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0 Tc 0.977 Tw -3.021 -1.218 Td [(\210)-9.4(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\026\027)-0.6(\026)-33.1(\035)2.2(\017)2.7( \007)-20.1(\026\027)1.7(\027)1.7(\t)-12.8(\b)-9.3(:)]TJ /T1_3 1 Tf -0.028 Tc 1.005 Tw [( \221)-23(\020)-33.2(\f)-18.2(\005)-23.5(\032)-25(\020)]TJ /Span<>> BDC 19.116 0 Td ( )Tj EMC [(\217.)0.5(\211)-3.7(.)-20.2(,)-28( )]TJ -0.029 Tc 0.029 Tw -19.116 -1.218 Td [(\206)-39.5(\r)-21.9(\026)-20.2(\t)-18.8(\025)-18.9(\006)-26.3(\027)-22.4(\021)]TJ /Span<>> BDC 3.867 0 Td ( )Tj EMC [(\211)-4.7(.\001.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -3.867 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.024 Tc 0.024 Tw 7.694 0 Td [( \036\024)-14.2(\027)-44.6(\f)-20.7(\027)-17.3(\021)-18.5(\022)-4.7(\007)]TJ /Span<>> BDC 3.85 0 Td ( )Tj EMC [(\206)69.9(.)4.5(\211.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.543 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf [( \205)27.6(\r)-4.3(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.5(.)7.3(\003)-2.3(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.276 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 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/T1_1 1 Tf -0.002 Tc 0.715 Tw T* [(D)-3.6(a)-10.4(t)-29.7(a)-2( p)-5.8(r)-8(o)-9(c)-1.8(e)-15.3(s)-14.8(s)-18.6(i)5.1(n)-3.8(g)-2( an)-6.6(d)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_3 1 Tf 0 Tc 0.713 Tw 14.072 0 Td [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(al)4.3(u)6.1(r)7.7(a)-14(, )]TJ -0.005 Tc 0.005 Tw -14.072 -1.218 Td [(V)20.9(a)-5.1(le)-6.7(r)-40.3(i)-5.1(y)]TJ /Span<>> BDC 2.664 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(R)5.2(umy)-1.2(a)-5.8(n)-1.2(t)-34.1(se)-9(v)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.752 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.2(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(E)-3.6(s)4.9(e)-1.9(l)4.8(e)-4(v)-28.6(i)2.6(c)1.8(h)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf -0.006 Tc 0.006 Tw 3.238 0 Td [( D)-8(mi)-5(t)-11.4(r)-41.3(i)-2.6(i)]TJ /Span<>> BDC 2.951 0 Td ( )Tj EMC [(A)-18.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(S)9.8(ur)-3.6(o)-6.6(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 15.976 47.494 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.124 Tw T* (\213\f\036\035\036\r\017\004 \217\024\n\026\027 \200\035\026\007\017\n\017\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \027\026\004\026\035\034\027\017\022 )Tj 0.238 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 \022\035\017\027\017\022\017 \022\026\235\036\007\030\t\ \r\024\036\027)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\ \036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\ \036\n\017\017 )Tj 0.003 Tw T* (\017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, \232\210\211\200\210 \253\222\026\ \027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005 )Tj 0.326 Tw T* [(\n\036\007\017\022\024-\f\024\006\017\026\035\034\027\t\005 )0.6(\017\027\f\021\017\021\031\021\273, )0.6(\020.)]TJ /Span<>> BDC ( )Tj EMC 14.925 0 Td (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; )Tj 0 Tw -14.925 -1.218 Td (ORCID 0000-0003-3249-233X; SPIN-\022\024\007: 1037\2268736)Tj 0.086 Tw T* (\222\026\n\024\b\017\027 \210\035\036\020 \230\020\024\030\036\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\004\026\035\034\027\017\022 \024\021\007\036\035\036\027\017\ \016 \027\036)Tj 0 Tw (-)Tj 0.042 Tw T* (\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\017\017 \205\206\ \025\211 \2531602 \200\025\206\273 \204\210 \217\205, \217\024\f\021\024\ \r-)Tj 0.618 Tw T* (\027\026-\212\024\027\031; ORCID 0009-0004-9011-872X; SPIN-\022\024\007:\ )Tj 0 Tw T* (2945\2269017)Tj 0.222 Tw T* (\202\035\017\n\024\r \215\026\r\036\035 \202\035\017\n\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\031\001\026\021\036\035\034 \024\030\007\017\027\026\021\031\ \030\t )Tj 0.15 Tw 0 -1.218 TD (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.042 Tw 0 -1.218 TD (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0009-00\ 07-3105-764X; )Tj 0 Tw 0 -1.218 TD (SPIN-\022\024\007: 5928\2263805)Tj 0.327 Tw T* (\207\026\035\033\030\026 \210\035\036\020 \200\026\035\036\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030\001\017\005 \023\030\036)Tj 0 Tw (-)Tj 0.821 Tw T* (\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\ \036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017\ )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.337 Tw T* [(\217\205, )0.5(\232\210\211\200\210 )0.6(\253\222\026\027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005\ )0.5(\n\036\007\017\022\024-\f\024\006\017\026\035\034)]TJ 0 Tw (-)Tj 0.006 Tw T* (\027\t\005 \017\027\f\021\017\021\031\021\273, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-)Tj 0 Tw T* (7826-8056; SPIN-\022\024\007: 9260\2269850)Tj 0.229 Tw T* (\217\031\n\016\027\006\036\r \200\026\035\036\030\017\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \023\030\036\023\024\007\026)Tj 0 Tw (-)Tj 0.2 Tw T* (\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\036\027\027\024\ -\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\036\027\ \027\024-)Tj 0.429 Tw T* (\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\036\n\017\017 \ \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, )Tj 0.571 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-7526-6282; )Tj 0 Tw T* (SPIN-\022\024\007: 8166\2269820)Tj 0.311 Tw T* [(\222\031\030\024\r )0.5(\212\n\017\021\030\017\005 )0.6(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 13.948 0 Td [(\227 )0.5(\007.\n.\027., )0.6(\023\030\024\235\036\f)]TJ 0 Tw (-)Tj 0.238 Tw -13.948 -1.218 Td (\f\024\030, \027\026\004\026\035\034\027\017\022 \022\026\235\036\007\030\ \t \r\024\036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\ \017\017 )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.038 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 02-4519-0018; )Tj 0 Tw T* (SPIN-\022\024\007: 5346\2261613)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(R)11(oman V. Eselev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3249-233X)Tj T* (Oleg)Tj /Span<>> BDC ( )Tj EMC (I. Samokhin)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0004-9011-872X)Tj T* [(P)40(avel A. Al)-30.9(imov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3105-764X)Tj T* [(Oleg V. Bal)35.1(ur)-33(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7826-8056)Tj T* [(V)25(aler)-37(iy N. Rumy)22.1(antsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7526-6282)Tj T* [(Dmi)-24(tr)-36.9(i)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(A. Sur)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4519-0018)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 213.3539 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.303 Tw 8 0 0 8 42.5197 200.5192 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bo)-14(wen)]TJ /Span<>> BDC ( )Tj EMC [(D, Hughes T)47.1(h, Jul)-30.9(ieb\370-Jones)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(our)-15(nier\241s gan)]TJ 0 Tw (-)Tj 0.011 Tc 0.414 Tw -1.296 -1.25 Td [(gr)-24.1(ene: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24.2(ev)-16.1(iew of)]TJ /Span<>> BDC ( )Tj EMC [(p)24.8(r)-24.2(edic)-16.1(t)-32.2(i)-16.1(ve scor)-37.2(ing sy)-13.1(stems and p)24.8(r)-33.1(a)-17.2(c)-16.1(t)-32.2(ical)11( )]TJ 0.004 Tc 0.35 Tw 0 -1.25 TD [(guide )0.5(for )0.5(p)31.9(a)15(t)-32(ient )0.5(mana)-17(gement. )]TJ /T1_3 1 Tf 14.269 0 Td [(Ther )0.5(Adv )0.5(Infect )0.5(Dis.)]TJ /T1_1 1 Tf [( )0.5(2024 )0.5(Mar)4( )]TJ 0 Tc 0.023 Tw -14.269 -1.25 Td [(19;11:20499361241238521. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1177/20499361241238521)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.381 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td [(L)34.8(ewis)]TJ /Span<>> BDC ( )Tj EMC (GD, Majeed)Tj /Span<>> BDC ( )Tj EMC [(M, Ol)-16.2(ang)]TJ /Span<>> BDC ( )Tj EMC [(C)19.8(A, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)9.8(our)-15.2(nier\241s Gangr)-24.1(ene)10( )]TJ 0 Tc 0.217 Tw -1.327 -1.25 Td [(Dia)-17(gnosis )0.5(and )0.5(T)50(r)-24(ea)15(tment: )0.6(A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-12.9(stema)15(t)-32(ic )0.5(R)13(ev)-16(iew. )]TJ /T1_3 1 Tf 0 Tw 20.507 0 Td (Cureus)Tj /T1_1 1 Tf 0.217 Tw [(. )0.5(2021 )0.5(O)-16(c)-16(t )]TJ 0.023 Tw -20.507 -1.25 Td [(21;13\(10\):e18948. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.18948)]TJ 0 0 0 1 k /GS1 gs 0.197 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\206\030\017\027\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \206\030\017\027\036\r)Tj /Span<>> BDC ( )Tj EMC (\025.\204. \203\036\022\030\024\021\017\017\030\031\033\013\017\005 \235\ \026\f\006\017\017\021. \222\026\027\022\021-)Tj 0.023 Tw -1.296 -1.25 Td (\215\036\021\036\030\002\031\030\020, 2008. \230\007\026\021\036\035\034\ \f\021\r\024: \206\017\023\023\024\022\030\026\021. 120 \f.)Tj 0.245 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\026\f\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217., \222\026\n\024\b\r\026\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \003\026\r\030\026\032\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \222\024\007\036\030\032\026\027\017\036 )Tj 0.003 Tw -1.296 -1.25 Td (\027\036\024\021\035\024\032\027\024\005 \f\023\036\006\017\026\035\017\ \017\030\024\r\026\027\027\024\005 \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036)Tj 0 Tw (-)Tj 0.008 Tc 0.349 Tw T* (\n\036\027\027\024\n \r\024\036\027\027\024\n \022\024\027\235\035\017\022\ \021\036. )Tj /T1_3 1 Tf (\215\027\030\022\006\022\025\020: \023\027\031\032\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\020\n\023\022\n\020.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2023;4:7\22617. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.56871/MTP.2023.98.31.042)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.604 Tw 29.055 15 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.346 0 Td (\213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 0 Tc 0.104 Tw -1.346 -1.25 Td (4D-\025\024\027\006\036\023\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \r\027\036\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\005\ )Tj 0.111 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \200\f\036 \035\017 \021\026\ \022 \024\007\027\024\027\026\004\027\024? )Tj /T1_3 1 Tf 0 Tw (\004\031\f\022\023\032\020\021\026\020)Tj /T1_1 1 Tf 0.111 Tw (. 2025;1:59\226)Tj -0.018 Tw T* [(66. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1819-1495-2025-1-59-66)Tj 0 0 0 1 k /GS1 gs -0.018 Tw [( \217\036\032\017\n \007\024\f\021\031\023\026: ht)-30(tp://)]TJ 0 Tw T* [(pol)35(y-tr)-32.9(auma.r)-22(u/inde)-17.9(x.php/pt/ar)-22(t)-32(icle/v)-15.9(iew/587.)]TJ 0.105 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(avenson)]TJ /Span<>> BDC ( )Tj EMC (GS, Cohen)Tj /Span<>> BDC ( )Tj EMC [(A. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15(al injur)-37(ies. )]TJ /T1_3 1 Tf 0 Tw [(Amer)-37(ican )]TJ 0.011 Tc 0.389 Tw -1.296 -1.25 Td [(J)0.5(o)0.6(u)0.5(r)-13.4(n)0.5(a)0.5(l)0.6( o)0.5(f)]TJ /Span<>> BDC 4.503 0 Td ( )Tj EMC [(S)0.6(u)0.5(r)0.5(g)12.6(e)0.5(r)-42.5(y)]TJ /T1_1 1 Tf 3.671 0 Td [(.)0.5( 1)0.5(9)0.5(7)0.6(1)0.5(;)0.5(1)0.5(2)0.6(2)0.5(\()0.5(2)0.6(\))0.5(:)0.5(2)0.6(2)0.5(6)0.5(\226)0.5(2)0.6(3)0.5(0)0.5(.)0.6( d)-15.5(o)0.5(i)0.6(:)]TJ /Span<>> BDC 12.615 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw [(1)0.5(0)0.6(.)0.5(1)0.6(0)0.5(1)0.5(6)0.5(/)0.6(0)0.5(0)0.5(0)0.5(2)0.6(-)]TJ 0 Tc 0 Tw -20.788 -1.25 Td (9610\(71\)90322-9)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\036\f\017\022\017\027)Tj /Span<>> BDC ( )Tj EMC 3.852 0 Td [(\230.\203., )0.5(\215\036\030\036\b\024\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.143 0 Td [(\222.\203., )0.5(\210\027\027\017\006\036\r)]TJ /Span<>> BDC ( )Tj EMC 6.079 0 Td [(\230.\213., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.083 0 Td [(\f\024\026\r\021. )0.5(\233\021\026\023\027\024\036 )]TJ 0.19 Tw -21.453 -1.25 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\036 )0.5(\035\036\004\036\027\017\036 \030\026\027\036\027\017\005 \r\027\036\002\ \030\033\001\017\027\027\024\020\024 \024\021\007\036\035\026 \023\030\016\ \n\024\005 )]TJ 0 Tw T* (\022\017\001\022\017. )Tj /T1_3 1 Tf 3.197 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_1 1 Tf 0.04 Tw [(. 2024;23\(3\):41\22649. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.197 -1.25 Td (7556-2024-23-3-41-49)Tj 0 0 0 1 k /GS1 gs 0.012 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\017\n)Tj /Span<>> BDC ( )Tj EMC (\230.\224., \215\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \204\031\f\026\017\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\030\017\027\006\017\023\t \024\022\026\026)Tj 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.6396 56.0378 Tm (147)Tj ET endstream endobj 640 0 obj <>/Border[0 0 0]/H/N/Rect[150.572 177.815 248.484 168.519]/Subtype/Link/Type/Annot>> endobj 641 0 obj <>/Border[0 0 0]/H/N/Rect[120.228 147.815 193.851 138.519]/Subtype/Link/Type/Annot>> endobj 642 0 obj <>/Border[0 0 0]/H/N/Rect[103.02 87.8152 203.515 78.5192]/Subtype/Link/Type/Annot>> endobj 643 0 obj <>/Border[0 0 0]/H/N/Rect[301.49 177.815 417.482 168.519]/Subtype/Link/Type/Annot>> endobj 644 0 obj <>/Border[0 0 0]/H/N/Rect[446.33 147.815 496.063 138.359]/Subtype/Link/Type/Annot>> endobj 645 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 137.815 331.696 128.519]/Subtype/Link/Type/Annot>> endobj 646 0 obj <>/Border[0 0 0]/H/N/Rect[443.335 107.815 496.063 98.3592]/Subtype/Link/Type/Annot>> endobj 647 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 97.8152 349.04 88.5192]/Subtype/Link/Type/Annot>> endobj 655 0 obj <> endobj 654 0 obj <> endobj 653 0 obj <> endobj 652 0 obj <> endobj 651 0 obj <> endobj 650 0 obj <> endobj 649 0 obj <> endobj 648 0 obj <> endobj 610 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.06 Tw 10 0 0 10 70.8661 724.8299 Tm [(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\031\033 )0.6(\(\006\036\235\021\030\017\026\022\f\024\027 )0.5(2 \020)]TJ /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC 16.79 0 Td [(2 \030\026\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\031\021)Tj 0 Tw (-)Tj 0.029 Tw -16.79 -1.218 Td (\022\017, \n\036\021\030\024\027\017\007\026\024\035 100 \n\035)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017\), \007\036\017\027\021\024\022)Tj 0 Tw (-)Tj 0.649 Tw 0 -1.218 TD (\f\017\022\026\006\017\024\027\027\031\033, \023\030\024\021\017\r\024\r\ \024\f\023\026\035\017\021\036\035\034\027\031\033, \f\017\n\023\021\024\ \n\026)Tj 0 Tw (-)Tj 0.337 Tw T* [(\021\017\004\036\f\022\031\033. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\255\036\022\021\017\r\027\t\n )0.5(\023\030\017\004\017\027\026\n \r\t\023\024\035\027\036\027\017\036 )]TJ 0.266 Tw T* (\002\026\022\021\036\030\017\024\035\024\020\017\004\036\f\022\024\020\024\ \017\f\f\035\036\007\024\r\026\027\017\016 \030\026\027\036\r\024\020\024\ \024\021\007\036)Tj 0 Tw (-)Tj 0.088 Tw T* (\035\016\036\n\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036\023\036\030\036\004\017\f\035\036\027\027\t\b \220\021\026\023\ \026\b \027\036 )Tj 0.14 Tw 0 -1.218 TD (\r\t\023\024\035\027\016\035\024\f\034. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\036 \f\031\021\022\017 \023\026\006\017\036\ \027\021 \023\036\030\036\r\036)Tj 0 Tw (-)Tj -0.027 Tw 0 -1.218 TD (\007\036\027 \026\r\017\026\006\017\024\027\027\t\n \021\030\026\027\f\023\ \024\030\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\036 \n\036\007\017\006\017\027\f\022\024\036 )Tj -0.039 Tw T* (\031\004\030\036\032\007\036\027\017\036 4 \211\204\215 \007\035\016 \023\ \030\024\007\024\035\032\036\027\017\016 \035\036\004\036\027\017\016. \200\ )Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\036\005\001\036\n \023\024\035\031\004\026\035 \022\024\027\f\036\030\ \r\026\021\017\r\027\024\036 \035\036\004\036\027\017\036: \023\030\024\007\ \024\035\032\036)Tj 0 Tw (-)Tj 0.171 Tw T* [(\027\026 )0.5(\026\027\021\017\002\017\024\021\017\022\024\021\036\030\026\023\017\016\ )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 11.743 0 Td [(\f\b\036\n\036 )0.5(\023\030\036\007\t\007\031\013\036\020\024 )0.6(\220\021\026)]TJ 0 Tw (-)Tj 0.103 Tw -11.743 -1.218 Td (\023\026, \023\036\030\036\r\016\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\016\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\024\030\026\f\021\r\024\030\017\n\024\005 \024\f\027\024\r\036\ )Tj 0.025 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\). \025)Tj /Span<>> BDC ( )Tj EMC (14-\n \f\031\021\022\026\n \023\024\f\035\036 \024\023\036\030\026\006\017\ \017 \016\r\035\036\027\017\016 \r\024\f)Tj 0 Tw (-)Tj 0.216 Tw 0 -1.218 TD (\023\026\035\036\027\017\016 \030\036\020\030\036\f\f\017\030\024\r\026\035\ \017, \035\026\002\024\030\026\021\024\030\027\t\036 \023\024\022\026\026\ \021\036\035\017 )Tj 0.074 Tw 0 -1.218 TD (\027\024\030\n\026\035\017\024\r\026\035\017\f\034, \030\026\027\t \n\024\ \001\024\027\022\017 \026\032\017\035\017 \r\021\024\030\017\004\027\t\n\ )Tj 0 Tw T* (\027\026\021\016\032\036\027\017\036\n \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.267 Tw T* [(\215\030\017 \r\t\023\024\035\027\036\027\017\017 \030\036\022\021\024\030\ \024\n\026\027\024\f\022\024\023\017\017 )0.5(\024\021\n\036\004\036\027\024 \026)]TJ 0 Tw (-)Tj 0.246 Tw T* (\032\017\r\035\036\027\017\036 \030\026\027\t \023\030\016\n\024\005 \022\ \017\001\022\017 \r\021\024\030\017\004\027\t\n \027\026\021\016\032\036\ )Tj 0 Tw (-)Tj 0.297 Tw T* [(\027\017\036\n. )0.5(\215\026\006\017\036\027\021 )0.6(\r\t\023\017\f\026\027 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.423 0 Td [(\026\n\002\031\035\026\021\024\030\027\024\036 )0.5(\035\036\004\036\027\017\036 )]TJ 0.233 Tw -12.423 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026\006\017\036\005 \023\035\026\027\024\r\ \024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\ \036\027\017\016 )Tj 0.267 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \r\024\f\f\021\026\027\024\r\035\036\027\017\016 \ \027\036\023\030\036\030\t\r\027\024\f\021\017 \021\024\035\f\021\024\005\ )Tj 0 Tw T* (\022\017\001\022\017 \004\036\030\036 3 \n\036\f\016\006\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 432.5578 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.013 Tw 10 0 0 10 70.8661 408.2018 Tm (\210\f\027\024\r\027\t\n \023\024\007\b\024\007\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \200\002\217\215\025 )Tj 0.234 Tw T* (\016\r\035\016\036\021\f\016 \023\030\017\n\036\027\036\027\017\036 4D-\022\ \024\027\006\036\023\006\017\017. \210\007\027\026\022\024 \f\031\013\036\ )Tj 0 Tw (-)Tj 0.201 Tw T* [(\f\021\r\031\036\021 )0.5(\030\026\027\024\030\024\007\027\024\f\021\034 )0.6(\023\024\007\b\024\007\024\r )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 14.855 0 Td [(\030\036\026\035\017\026\006\017\017 )0.6(\022\035\033)]TJ 0 Tw (-)Tj 0.146 Tw -14.855 -1.218 Td (\004\036\r\t\b \036\036 \220\035\036\n\036\027\021\024\r, \004\021\024 \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\t\b \022\035\017\027\017\004\036\f\022\017\ \b )Tj 0.028 Tw T* (\f\017\021\031\026\006\017\016\b \n\024\032\036\021 \024\022\026\026\021\ \034 \027\026\004\017\n\t\005 \022\035\017\027\017\004\036\f\022\017\005\ \220\235)Tj 0 Tw (-)Tj 0.241 Tw T* (\235\036\022\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 )Tj 0 Tw T* ([5,8,9].)Tj 0.173 Tw T* (\200 \023\030\036\007\f\021\026\r\035\036\027\027\024\n \022\035\017\027\ \017\004\036\f\022\024\n \f\035\031\004\026\036 \r\t\023\024\035\027\036\ \027\017\036 )Tj 0.069 Tw T* [(\024\f\027\024\r\027\024\020\024 )0.5(\220\035\036\n\036\027\021\026 )0.6(\025\024\027\006\036\023\006\017\017)]TJ /Span<>> BDC ( )Tj EMC 13.575 0 Td [(\227 )0.5(\024\021\r\036\007\036\027\017\036 )0.6(\023\026\f\f\026)]TJ 0 Tw (-)Tj 0.085 Tw -13.575 -1.218 Td (\032\026 \023\030\024\022\f\017\n\026\035\034\027\036\036 \030\026\027\036\ \027\017\016 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.07 Tw T* (\036\n\036 \026\020\035\031\001\036\027\017\016 \024\021\r\024\007\016\013\ \036\005 \004\026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017\ \002\036 )Tj 0.136 Tw T* (\r\024\n\024\032\027\024\f\021\017 \023\030\024\r\036\007\036\027\017\016\ \026\027\021\036\020\030\026\007\027\024\020\024 \007\017\f\021\026\035\ \034\027\024\020\024 )Tj 0.088 Tw T* (\024\021\n\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\005 \n\036\030\036 \023\024\r\035\ \017\016\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\026)Tj 0 Tw (-)Tj 0.257 Tw T* (\n\017\027\026\006\017\033 \022\035\036\021\004\026\021\024\004\027\t\b \ \023\030\024\f\021\030\026\027\f\021\r \021\026\026 \f\024\007\036\030\032\ \017)Tj 0 Tw (-)Tj 0.16 Tw T* (\n\t\n \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \021\026\022\024\020\024 \020\030\024\027\024\ \020\024 \024\f)Tj 0 Tw (-)Tj T* (\035\024\032\027\036\027\017\016, \022\026\022 \206\205.)Tj 0.17 Tw T* [(\203\036\024\002\b\024\007\017\n \023\036\030\f\024\027\026\035\017\017\ \030\024\r\026\027\027\t\005 )0.5(\023\024\007\b\024\007 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 )Tj 0.046 Tw T* (\220\035\036\n\036\027\021\024\r \025\024\027\006\036\023\006\017\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \031\030\024\r\027\016 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026)Tj 0 Tw (-)Tj 0.095 Tw T* (\030\026\022\021\036\030\026 \023\024\r\030\036\032\007\036\027\017\016 \ \022\017\001\022\017, \021\016\032\036\f\021\017 \f\024\f\021\024\016\027\ \017\016 \030\026)Tj 0 Tw (-)Tj -0.073 Tw T* (\027\036\027\024\020\024. \200)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\027\024\005 \f\017\021\031\026\006\017\017 \002\024\ \035\036\036 \006\036\035\036\f\024\024\002\030\026\027\t\n )Tj 0.355 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021\f\016 \r\026\030\017\026\027\ \021 \023\036\030\r\017\004\027\024\005 \b\017\030\031\030\020\017\004\036\ \f\022\024\005 )Tj 0.105 Tw T* [(\021\026\022\021\017\022\017, )0.6(\030\036\026\035\017\024\r\026\027\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.181 0 Td [(\f\035\036\007\031\033\013\036\n )0.6(\024\002\255\036\n\036: )0.5(\035\026\023\026)]TJ 0 Tw (-)Tj 0.027 Tw -11.181 -1.218 Td [(\030\024\021\024\n\017\016, )0.5(\030\036\r\017\017\016 )0.6(\024\030\020\026\027\024\r )0.5(\002\030\033\001\027\024\005 )0.6(\023\024\035\024\f\021\017, )0.5(\235\024\030\n\017)]TJ 0 Tw (-)Tj 0.154 Tw T* (\030\024\r\026\027\017\036 \007\r\031\f\021\r\024\035\034\027\024\005 \f\ \017\020\n\024\f\021\024\n\t, \023\024\f\035\024\005\027\024\036 \031\001\ \017)Tj 0 Tw (-)Tj 0.114 Tw T* (\r\026\027\017\036 \035\026\023\026\030\024\021\024\n\027\024\005 \030\026\ \027\t, \r\t\023\024\035\027\036\027\017\036 \007\017\f\021\026\035\034\027\ \024\020\024 )Tj 0.005 Tw T* [(\024\021\n\t\r\026\027\017\016 )0.6(\024\021\022\035\033\004\036\027\027\024\020\024 )0.5(\031\004\026\f\021\022\026 )0.6(\022\017\001\022\017 )0.5(\004\036\030\036 )0.6(\f\021\024\n\031, )]TJ 0.09 Tw T* (\024\021\022\026 \024\021 \031\001\017\r\026\027\017\016 \030\026\027\036\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \036\020\024 \027\036\027\026\004\017\021\036\035\034)Tj 0 Tw (-)Tj 0.167 Tw T* (\027\024\020\024 \030\026\n\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\026 \024\021 \030\031\021\017\027\027\024\020\024 \002\017\ \035\026\021\036\030\026\035\034\027\024\020\024 )Tj 0.108 Tw 23.244 64.543 Td (\023\026\030\026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\ \027\017\030\024\r\026\027\017\016 \027\036\017\n\036\027\036\027\027\t\ \b \022\035\036\021)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\r \021\ \026\026.)Tj 0.349 Tw 0 -1.218 TD (\211\f\021\030\026\027\036\027\017\036 \027\036\007\036\f\021\030\031\022\ \021\017\r\027\024\020\024 \(\n\036\027\036\036 \274 \024\022\030\031\032\ \027\024)Tj 0 Tw (-)Tj 0.102 Tw 0 -1.218 TD (\f\021\017\) \007\036\235\036\022\021\026 \f\021\036\027\022\017 \r\027\036\ \002\030\033\001\017\027\027\024\020\024 \024\021\007\036\035\026 \023\030\ \016\n\024\005 )Tj 0.241 Tw 0 -1.218 TD (\022\017\001\022\017 \016\r\035\016\036\021\f\016 \r\026\032\027\t\n \220\ \035\036\n\036\027\021\024\n \025\024\027\006\036\023\006\017\017, \027\024\ )Tj 0.005 Tw 0 -1.218 TD (\027\036 \023\030\017\024\030\017\021\036\021\027\t\n. \211\004\017\021\t\ \r\026\033\021\f\016 \f\035\036\007\031\033\013\017\036 \235\026\022\021\ \024\030\t: )Tj 0.159 Tw 0 -1.218 TD (\007\024\f\021\031\023\027\024\f\021\034 \030\026\027\036\027\017\016 \007\ \035\016 \031\001\017\r\026\027\017\016, \024\002\255\036\n \023\024\r\030\ \036\032)Tj 0 Tw (-)Tj 0.067 Tw 0 -1.218 TD [(\007\036\027\017\016, )0.5(\f\024\f\021\024\016\027\017\036 )0.6(\023\026\006\017\036\027\021\026, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 12.527 0 Td [(\021\026\022\032\036 )0.5(\n\036\007\017\022\024-\021\026\022\021\017\004\036)]TJ 0 Tw (-)Tj 0.161 Tw -12.527 -1.218 Td (\f\022\026\016 \024\002\f\021\026\027\024\r\022\026, \024\023\t\021 \b\017\ \030\031\030\020\026. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \r\t\023\024\035\027\036\027\017\016 )Tj 0.134 Tw T* (\007\026\027\027\024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024\ \023\030\017\036\n\026 \027\036\024\002\b\024\007\017\n\024 \017\002\036\ \020\026\021\034 )Tj -0.026 Tw T* (\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 \023\024\r\030\ \036\032\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\026\n\017\027\026\006\017\017 \022\035\036\021)Tj 0 Tw (-)Tj T* (\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\r \021\ \026\026.)Tj 0.263 Tw T* (\217\031\021\017\027\027\t\005 \b\026\030\026\022\021\036\030 \023\026\030\ \026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\027\017\030\ \024\r\026\027\017\016 )Tj 0.037 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\027\024\020\024 \007\024\f\021\031\023\ \026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \027\036 \023\024\r\024\035\016\036\021 )Tj 0.172 Tw T* (\022\024\027\021\030\024\035\017\030\024\r\026\021\034 \020\035\031\002\017\ \027\031 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\036 \007\030\036\027\026\032\026, \004\021\ \024 )Tj 0.055 Tw T* [(\026\022\024\027\024\n\036\030\027\024 \f\023\024\f\024\002\f\021\r\031\ \036\021 )0.5(\r\t\f\024\022\017\n \030\017\f\022\026\n \016\021\030\024\020\036\027)]TJ 0 Tw (-)Tj 0.051 Tw T* (\027\t\b \023\024\r\030\036\032\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \024\002\036\f\023\036\004\017\r\026\036\021 \027\026\007\036\032\ \027\031\033 \023\030\024)Tj 0 Tw (-)Tj 0.168 Tw T* (\235\017\035\026\022\021\017\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\031\033 \007\017\026\020\027\024\f\021\ \017\022\031 \017\027\235\036\022\006\017)Tj 0 Tw (-)Tj T* (\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 [5,7,10].)Tj 0.042 Tw T* (\206\205, \016\r\035\016\016\f\034 \n\024\007\036\035\034\033 \f\036\023\ \f\017\f\026, \031\004\017\021\t\r\026\016 \235\031\035\034\n\017\027\026\ \027\021)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\024\036 \021\036\004\036\027\017\036, \023\030\036\007\f\021\026\r\035\ \016\036\021 \024\007\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \020\030\024\027\t\b )Tj 0.039 Tw T* (\024\f\035\024\032\027\036\027\017\005 \024\020\027\036\f\021\030\036\035\ \034\027\t\b \030\026\027\036\027\017\005 \021\026\026, \f\024\023\030\016\ \032\036\027)Tj 0 Tw (-)Tj 0.149 Tw T* (\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \035\036\021\026\035\034\027\024\f\021\034\033 [2\ ,3]. \215\030\036\007\f\021\026\r\035\036\027\027\t\005 )Tj 0.314 Tw T* (\022\035\017\027\017\004\036\f\022\017\005 \023\030\017\n\036\030 \027\026\ \020\035\016\007\027\024 \007\036\n\024\027\f\021\030\017\030\031\036\021\ , \004\021\024 )Tj 0.459 Tw T* (\f\r\024\036\r\030\036\n\036\027\027\026\016 \007\017\026\020\027\024\f\021\ \017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\026\016 \b\017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.606 Tw T* [(\004\036\f\022\026\016 )0.6(\021\026\022\021\017\022\026, )0.5(\024\023\036\030\036\032\026\033\013\026\016 )0.6(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 )]TJ 0.421 Tw T* (\017\027\235\036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\ \f\f\026, \016\r\035\016\036\021\f\016 \036\007\017\027\f\021\r\036\027\027\ \t\n )Tj 0.012 Tw T* (\022\035\033\004\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\033 \032\017\027\017 \023\026\006\017\036\ \027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \027\024)Tj 0 Tw (-)Tj T* (\024\035\024\020\017\004\036\f\022\024\005 \235\024\030\n\024\005.)Tj 0.004 Tc 0.228 Tw T* [(\025\024\027\006\036\023\006\017\016 )0.5(\n\027\024\020\024\220\021\026\023\027\024\020\024 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016)4( )]TJ 0.273 Tw T* (\026\022\035\033\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\r\t\r\036\030\036\027\027\t\b \027\026\007\036\032\027\t\b \021\026\022\ \021\017\004\036\f\022\017\b)4( )]TJ 0.117 Tw T* [(\030\036\001\036\027\017\016\b. )0.5(\222\024\022\030\026\013\036\027\027\t\005 )0.5(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\005 )0.5(\026\035\020\024\030\017\021\n)4( )]TJ 0.047 Tw T* (\024\002\031\f\035\024\r\035\036\027 \027\036 \024\021\f\031\021\f\021\r\ \017\036\n \f\030\036\007\f\021\r, \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\022\024-\021\026\022\021\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.007 Tw T* (\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\002\024\021\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\031\f\035\024\r\017\016\b \n\026\f\f\024\r\024\020\024)4( )]TJ 0.01 Tw T* [(\023\024\f\021\031\023\035\036\027\017\016. \221\026\022, \027\026\023\030\ \017\n\036\030, \b\030\024\027\024\035\024\020\017\004\036\f\022\017\036\ \030\026\n\022\017)4( )]TJ 0.165 Tw T* [(\r\t\023\024\035\027\036\027\017\016 \002\026\022\021\036\030\017\024\035\ \024\020\017\004\036\f\022\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\n\024)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.197 Tw T* (\020\031\021 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\036\f\022\024\035\034\022\024 \030\026 \023\030\036\r\t\001\026\021\ \034 \r\030\036\n\016 \027\026\b\024\032\007\036\027\017\016)4( )]TJ 0.245 Tw T* (\023\026\006\017\036\027\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\n \233\204\233, \004\021\024 \016\r\ \035\016\036\021\f\016 \027\036\f\021\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.152 Tw T* [(\030\036\024\021\017\023\027\t\n \007\035\016 \253\n\017\030\027\024\005\ \273 \b\017\030\031\030\020\017\017. \216\017\030\031\030\020\017\004\036\ \f\022\024\005)4( )]TJ 0.297 Tw T* [(\022\024\n\026\027\007\036 \024\021\f\035\036\007\017\021\034 \030\036\031\ \035\034\021\026\021 \f\r\024\036\005 \030\026\002\024\021\t \023\024\f\035\ \036)4( )]TJ 0.137 Tw T* (\023\036\030\036\r\024\007\026 \023\026\006\017\036\027\021\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC [(\f\035\036\007\031\033\013\017\005 \233\204\233 \026\004\026\f\021\031\033\ \027\036)4( )]TJ 0.513 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021\f\016 \r\024\n\024\032\027\ \t\n \r)Tj /Span<>> BDC ( )Tj EMC [(\f\017\035\031 \024\002\255\036\022\021\017\r\027\t\b)4.1( )]TJ -0.004 Tw T* (\023\030\017\004\017\027.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 176.8198 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.044 Tw 10 0 0 10 303.3071 152.4638 Tm (\212\017\026\020\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233 \016\r\035\016\036\021\f\016 \026\022\021\031)Tj 0 Tw (-)Tj 0.195 Tw T* (\026\035\034\027\024\005 \023\030\024\002\035\036\n\024\005 \f\024\r\030\ \036\n\036\027\027\t\b \r\024\024\030\031\032\036\027\027\t\b \022\024\027\ )Tj 0 Tw (-)Tj 0.107 Tw T* (\235\035\017\022\021\024\r. \216\017\030\031\030\020\017\004\036\f\022\026\ \016 \023\024\n\024\013\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \007\024\035\032\027\026 )Tj 0.132 Tw T* (\017\n\036\021\034 \023\036\030\f\024\027\017\235\017\006\017\030\024\r\026\ \027\027\t\005 \023\024\007\b\024\007, \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017)Tj 0 Tw (-)Tj -0.09 Tw T* (\n\024\f\021\017 \024\021 \b\026\030\026\022\021\036\030\026 \030\026\027\ \036\027\017\016, \f\024\f\021\024\016\027\017\016 \023\026\006\017\036\027\ \021\026, \024\023\t)Tj 0 Tw (-)Tj -0.008 Tw T* (\021\026 \n\036\007\017\006\017\027\f\022\024\020\024 \023\036\030\f\024\ \027\026\035\026, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021 \n\036\007\017\022\024-\021\026\022\021\017\004\036)Tj 0 Tw (-)Tj 0.16 Tw T* (\f\022\024\005 \024\002\f\021\026\027\024\r\022\017. \217\026\002\024\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \n\027\024\020\024\220\021\026\023\027\024\020\ \024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.8652 56.0378 Tm (146)Tj ET endstream endobj 600 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 601 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 602 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 603 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 604 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 665 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\t\025\013)10(\025)21(\237\026)11(\017\224\t\025\004 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\004 \020\004\225\004\t\n\004 \224\025\016)-9.9(\026\005\017\202\017\b\204\004\013)10(\025 )]TJ 0 -1 TD [(\016\022\025\013\t\004\016)-9.9(\026\005\004\020\200\t\217\024 \005\017\t\004\t\n\004\024 \b\t\004\255\005\ \206\204\n\t\t\025\013)10(\025 \025\026)11(\202\004\020\017 )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n, \025\016)-10(\020\025\226\t\242\t\t\217\024 \013)10(\017\t\013\005\004\t\025\221 \210\002\005\t\200\004)]TJ 33.406 2 Td [(Multistage sur)31(gical tr)31(eatment of\022a\022victim with a\022gunsh)11(ot w)11(ound of\022th)11(e )]TJ -0.724 -1 Td [(e)21(xtr)21(aperitoneal par)-19.9(t of\022th)11(e r)31(ectum complicated b)10(y F)15(ournier\236)63(s gangr)31(ene)]TJ ET q 42.52 448.349 221.102 288.659 re W n q 221.1023475 0 0 290.0017943 42.5196833 448.2279928 cm /Im0 Do Q Q BT /T1_1 1 Tf -0.022 Tw 9 0 0 9 42.5197 437.5498 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \002\025\023\032\020\031\033\027\032\020\006\022\031\025\025\020\t \n\020\ \032\023\022\025\020: \021\024\n\032\013\023\022\027 \022)Tj /Span<>> BDC ( )Tj EMC (\030\032\027)Tj 0 Tw (-)Tj 0.19 Tw 0 -1.2 TD (\025\022\032\031\021\020\025\022\027 \b\025\031\235\025\031-\025\027\n\032\ \031\023\022\007\027\024\n\031\b\031 \031\007\020\b\020 \026\031\213\031\ \025\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031)Tj 0 Tw (-)Tj T* (\026\027\255\025\031\024\023\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.026 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Intraoperativ)13.1(e picture: )0.5(opening and drainag)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC (pu)Tj 0 Tw (-)Tj T* [(rulent-necro)13.1(tic focus of)]TJ /Span<>> BDC ( )Tj EMC [(the scro)13.2(tum and per)-36.9(ineum)]TJ ET q 42.52 100.97 221.102 282.875 re W n q /GS0 gs 221.1023475 0 0 284.2401643 42.5196795 100.8455849 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\n\031\025\007\020\023\027\f\017\025\013\235 \021\022\030 \033\031\024\ \f\027\031\033\027\032\020\006\022\031\025\025\031\235 \032\020\025\013)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Final appearance of)Tj /Span<>> BDC ( )Tj EMC [(the postoperativ)13.3(e w)12(ound)]TJ ET q 274.961 437.55 221.102 299.458 re W n q /GS0 gs 222.4476172 0 0 300.922376 274.9606323 437.5498524 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.037 Tw 9 0 0 9 274.9606 426.7498 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\031\024\023\031\t\025\022\027 \033\031\024\f\027\031\033\027\032\020\ \006\022\031\025\025\031\235 \032\020\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (4-\027 \024\r\023)Tj 0 Tw (-)Tj 0 -1.2 TD (\n\022 \033\031\024\f\027 \031\033\027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.012 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC (condition of)Tj /Span<>> BDC ( )Tj EMC [(the postoperativ)13.1(e w)12.1(ound on the)]TJ /Span<>> BDC ( )Tj EMC (4th )Tj 0 Tw T* [(d)26(ay af)-45.9(ter surg)12(er)-43(y)]TJ ET q 274.961 122.57 221.102 261.275 re W n q /GS0 gs 221.1023475 0 0 263.5943325 274.9606228 121.3782113 cm /Im3 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.219 Tw 9 0 0 9 274.9606 111.7701 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\031\024\023\031\t\025\022\027 \033\031\024\f\027\031\033\027\032\020\ \006\022\031\025\025\031\235 \032\020\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (14-\027 )Tj 0 Tw T* (\024\r\023\n\022 \033\031\024\f\027 \031\033\027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.038 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC (condition of)Tj /Span<>> BDC ( )Tj EMC [(the postoperativ)13(e w)12(ound on the)]TJ /Span<>> BDC ( )Tj EMC (14th )Tj 0 Tw T* [(d)26(ay af)-45.9(ter surg)12(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.5273 56.0378 Tm (145)Tj ET 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"ۄ-Q[LtHRJiА'$*UT7+F4Z]e K5&jS BUVS-:RFsa4G!(-=I{5Jٽ 2ThnZklj^URjN}~Y*F]!qQ̞xSʙm CuZod8n[n3sZV^f)@:0p삒\tK8Tw1IJѯ+Y+I%Q2kCUVQe1+2J(S]D jTR^RjTR endstream endobj 673 0 obj <>stream endstream endobj 672 0 obj <>stream endstream endobj 671 0 obj <>stream endstream endobj 670 0 obj <>stream endstream endobj 663 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.388 Tw 10 0 0 10 70.8661 724.8299 Tm (\027\036\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\017\004\036\ \f\022\024\005 \f\017\021\031\026\006\017\036\005, \021\030\036\002\031\033\ \013\036\005 )Tj 0.175 Tw 0 -1.218 TD [(\023\036\030\r\024\024\004\036\030\036\007\027\024\005 \007\017\026\020\027\ \024\f\021\017\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\036)Tj 0 Tw (-)Tj 0.093 Tw T* (\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\024\022\026\026\027\017\017 )0.5(\f\r\024\036\r\030\036\n\036\027\027\024\005 \b\017\030\031\030\020\017\004\ \036\f\022\024\005 )]TJ 0.069 Tw T* (\023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \024\002\255\036\n\036 \027\026\002\035\033\007\026\ \036\021\f\016 \002\t\f\021\030\024\036 \030\026\f)Tj 0 Tw (-)Tj T* (\023\030\024\f\021\030\026\027\036\027\017\036 \017\027\235\036\022\006\017\ \017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\026\033\013\017\036 \021\022\026\027\017 [2,3].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 639.5839 Tm [(\037\f\031\032\026\022\031\034)5( \032\r\224\225\026\025)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.152 Tw 10 0 0 10 70.8661 615.2279 Tm [(\215\026\006\017\036\027\021 )0.5(\216. )0.6(\023\024\035\031\004\017\035 )0.5(\024\f\022\024\035\024\004\027\024\036 )0.6(\030\026\027\036\027\017\036 )0.5(\r\t\f\024\022\024\022\017)]TJ 0 Tw (-)Tj 0.199 Tw T* (\027\036\021\017\004\036\f\022\017\n \030\026\027\016\013\017\n \220\035\ \036\n\036\027\021\024\n. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\024\021\022\017\036 \f\030\024\022\017 )Tj 0.033 Tw T* (\007\024\f\021\026\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023 \022\r\026\035\017\235\017\006\017\030\024\r\026\027\027\ \024\005 \n\036\007\017\006\017\027\f\022\024\005 )Tj 0.133 Tw 0 -1.218 TD (\023\024\n\024\013\017 \(2 \211\204\215\), \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \024\002\f\035\036\007\024\r\026\027\017\016 \031\f\021\026\ \027\024\r)Tj 0 Tw (-)Tj -0.041 Tw 0 -1.218 TD (\035\036\027 \007\017\026\020\027\024: \222\024\004\036\021\026\027\027\ \024\036 \024\f\022\024\035\024\004\027\024\036 \030\026\027\036\027\017\ \036 \020\024\035\024\r\t, )Tj 0.177 Tw 0 -1.218 TD [(\021\026\026, \022\024\027\036\004\027\024\f\021\036\005. \222\035\036\023\ \024\036 )0.5(\027\036\023\030\024\027\017\022\026\033\013\036\036 \030\026\027\036\027\ \017\036 )]TJ 0.046 Tw T* (\020\024\035\024\r\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\f\024\004\027\024\005 \024\002\035\026\f\021\017 \f\023\030\026\r\ \026. \222\035\036\023\024\036 \023\030\024\027\017\022\026)Tj 0 Tw (-)Tj 0.009 Tw T* (\033\013\036\036 \030\026\027\036\027\017\036 \023\030\024\n\036\032\027\ \024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \023\030\016\n\024\005 )Tj 0.142 Tw T* (\022\017\001\022\017. \204\027\024\032\036\f\021\r\036\027\027\024\036 \f\ \035\036\023\024\036 \030\026\027\036\027\017\036 \024\002\036\017\b \027\ \017\032)Tj 0 Tw (-)Tj 0.119 Tw T* (\027\017\b \022\024\027\036\004\027\024\f\021\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\027\017\022\026\033\013\017\n \030\026\027\036\027\017\036\n\ \023\030\026\r\024\020\024 )Tj 0.157 Tw T* (\022\024\035\036\027\027\024\020\024 \f\031\f\021\026\r\026. \215\026\006\ \017\036\027\021\031 \r\t\023\024\035\027\036\027\t \023\026\035\034\006\ \036\r\024\036 )Tj 0.248 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\n\024\021\030 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026\035\026\b, )Tj 0.149 Tw T* (\r\t\016\r\035\036\027\024 \027\036\007\036\f\021\030\031\022\021\017\r\027\ \024\036 \(\n\036\027\036\036 1/4 \024\022\030\031\032\027\024\f\021\017\ \) )Tj 0.196 Tw T* [(\030\026\027\036\027\017\036 \f\030\036\007\027\036\026\n\023\031\035\016\ \030\027\024\020\024 )0.5(\024\021\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017. )]TJ 0.013 Tw T* (\200\t\023\024\035\027\036\027\024 \027\036\024\021\035\024\032\027\024\036\ \024\023\036\030\026\021\017\r\027\024\036 \r\n\036\001\026\021\036\035\ \034\f\021\r\024. )Tj 0.299 Tw T* (\230)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\024\022\024\035\026 \024\023\036\030\026\006\017\017: \253\ \246\r\t\023\024\035\027\036\027\026 \f\030\036\007\017\027\027\026\016 \ )Tj 0.267 Tw T* (\035\026\023\026\030\024\021\024\n\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \023\026\021\024\ \035\024\020\017\004\036\f\022\024\020\024 )Tj 0.406 Tw T* (\024\021\007\036\035\016\036\n\024\020\024 \027\036\021, \023\024\r\030\036\ \032\007\036\027\017\005 \024\030\020\026\027\024\r \002\030\033\001\027\ \024\005 )Tj 0.233 Tw T* (\023\024\035\024\f\021\017 \027\036\021. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\r\017\017\017 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026)Tj 0 Tw (-)Tj 0.207 Tw T* [(\035\026\b )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 3.235 0 Td [(12 )0.5(\004\026\f\026\b )0.6(\031\f\035\024\r\027\024\020\024 )0.5(\006\017\235\036\030\002\035\026\021\026 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 15.608 0 Td [(7 )0.5(\f\n )0.5(\024\021 )]TJ 0.331 Tw -18.843 -1.218 Td (\026\027\026\035\034\027\024\020\024 \032\024\n\026 \r\017\031\026\035\017\ \017\030\024\r\026\027\024 \030\026\027\036\027\017\036 \f\021\036\027\022\ \017 )Tj 0.13 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 0,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (0,3 \f\n. \217\026\027\026 \031\001\017\021\026. \200\t\023\024\035\027\036\ \027\024 )Tj 0.289 Tw T* (\002\017\035\026\021\036\030\026\035\034\027\024\036 \023\026\030\026\030\ \036\022\021\026\035\034\027\024\036 \007\030\036\027\017\030\024\r\026\027\ \017\036 \023\030\024)Tj 0 Tw (-)Tj 0.394 Tw T* [(\n\036\032\027\024\f\021\027\t\n )0.6(\007\024\f\021\031\023\024\n. )0.5(\222\235\024\030\n\017\030\024\r\026\027\026 )0.5(\f\017\020\n\024\f\021\024\n\026 )]TJ 0.279 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\r\t\r\036\007\036\027\017\036\n \023\030\024\022\f\017\n\026\035\034\027\ \024\020\024 )0.5(\024\021\007\036\035\026, \007\017\f\021\026\035\034\027\t\005 )]TJ 0.045 Tw T* (\030\036\022\021\024\f\017\020\n\024\017\007\027\t\005 \024\021\007\036\035\ \021\024\035\f\021\024\005 \022\017\001\022\017 \031\001\017\021 \027\026\ \020\035\031\b\024 )Tj -0.037 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\020\030\031\032\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\031\033 \023\024\035\024\f\021\034. \200\t\023\024\035\ \027\036\027\024 \007\030\036\027\017\030\024)Tj 0 Tw (-)Tj 0.065 Tw T* [(\r\026\027\017\036 )0.5(\n\026\035\024\020\024 )0.6(\021\026\026. )0.5(\215\024\f\035\024\005\027\024\036 )0.6(\031\001\017\r\026\027\017\036 )0.5(\035\026\023\026\030\024\021\024\n)]TJ 0 Tw (-)Tj -0.048 Tw T* (\027\024\005 \030\026\027\t\246\273. \212\026\035\036\036 \f\026\027\017\ \021\026\030\027\t\n \021\030\026\027\f\023\024\030\021\024\n \007\024\f\ \021\026\r)Tj 0 Tw (-)Tj -0.034 Tw T* (\035\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\f\022\031\033 \024\030\020\026\027\017\026\006\ \017\033 3 \211\204\215, \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.032 Tw T* (\007\r\031\b \f\031\021\024\022 \023\024\035\031\004\026\035 \022\024\027\ \f\036\030\r\026\021\017\r\027\024\036 \035\036\004\036\027\017\036. \203\ \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\036)Tj 0 Tw (-)Tj 0.197 Tw T* (\021\034\017 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017 \220\r\026\022\031\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\002\027\024\036 )Tj 0.238 Tw T* [(\031\004\030\036\032\007\036\027\017\036 )0.6(4 )0.5(\211\204\215, )0.5(\020\024\f\023\017\021\026\035\017\017\030\024\r\026\027 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.83 0 Td (\024\021\007\036\035\036\027\017\036 )Tj 0.237 Tw -17.83 -1.218 Td (\027\036\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\017\017.\ \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\031\023\035\036\027\017\017 \f\024\f\021\024\016\027\017\036\ )Tj 0.063 Tw 0 -1.218 TD (\f\030\036\007\027\036\005 \f\021\036\023\036\027\017 \021\016\032\036\f\ \021\017, \032\026\035\024\002\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.195 Tw 0 -1.218 TD [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )0.5(\030\026\027, \n\036\f\021\026\b \f\021\024\016\027\017\016 \007\030\036\ \027\026\032\036\005, )]TJ -0.014 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \n\024\001\024\027\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\n\024\021\030\036: \035\026\023\026\030\024\021\024\n\027\026\016\ \030\026\027\026 )Tj 0.215 Tw T* (\002\036 \024\f\024\002\036\027\027\024\f\021\036\005, \022\017\001\036\ \004\027\026\016 \f\021\024\n\026 \235\031\027\022\006\017\024\027\017\030\ \031\036\021, )Tj 0.07 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\026\032\026\n \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\020\024 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\ )Tj 0 Tw (-)Tj -0.009 Tw T* (\004\026\021\022\017 \f\035\036\007\t \f\036\030\024\027\024-\020\036\n\ \024\030\030\026\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\016\ \036\n\024\020\024. )Tj 0.195 Tw T* (\204\024\001\024\027\022\026 \002\026\020\030\024\r\024-\006\017\026\027\ \024\021\017\004\027\024\020\024 \006\r\036\021\026, \027\026\004\017\021\ \036\035\034\027\024 )Tj 0.155 Tw T* (\031\r\036\035\017\004\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\023\026\006\017\017 \030\036\022\024 \002\024\035\036\ )Tj 0 Tw (-)Tj T* (\027\036\027\027\026\016, \022\030\036\023\017\021\017\030\031\036\021 \(\ \217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj -0.057 Tw T* [(\217\036\022\021\026\035\034\027\024: )0.6(\f\235\017\027\022\021\036\030 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.446 0 Td [(\021\024\027\031\f\036, )0.5(\f\035\036\007\t )0.6(\022\026\035\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.953 0 Td (\023\036\030\004\026\021\022\036 )Tj -0.01 Tw -18.399 -1.218 Td (\022\024\030\017\004\027\036\r\024\020\024 \006\r\036\021\026 \f\024 \f\035\ \036\007\026\n\017 \235\017\002\030\017\027\024\027\024-\020\027\024\005\ \027\024\020\024 )Tj 0.01 Tw 23.244 64.543 Td (\024\021\007\036\035\016\036\n\024\020\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\b\024\030\024\027\t\n \026\023\026\b\024\n. \221\036\n\023\036\030\ \026\021\031\030\026 \021\036\035\026 )Tj 0 Tw T* (37,8)Tj /Span<>> BDC ( )Tj EMC 5.83 0 0 5.83 321.407 715.9819 Tm (\260)Tj 0.411 Tw 10 0 0 10 324.322 712.6519 Tm (\222. \202\030\021\036\030\017\026\035\034\027\024\036 \007\026\r\035\036\ \027\017\036 110/70 \n\n \030\021.\f\021. )Tj 0.162 Tw -2.102 -1.218 Td [(\215\031\035\034\f )0.5(95 )0.5(\031\007./\n\017\027. )0.5(\232\026\f\021\024\021\026 )0.5(\007\t\b\026\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 15.662 0 Td [(\227 )0.5(18 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.657 0 Td [(1 )0.5(\n\017\027. )]TJ 0.407 Tw -19.32 -1.218 Td (\214\026\002\024\030\026\021\024\030\027\024: \020\036\n\024\020\035\024\ \002\017\027 119 \020/\035, \035\036\005\022\024\006\017\021\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.177 Tw T* (16,0)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 343.3089 679.4479 Tm (9)Tj 0.177 Tw 10 0 0 10 346.2239 676.1179 Tm [(/\035. \200\t\023\024\035\027\036\027\026 )0.5(\007\017\f\021\026\035\034\027\026\016 )0.5(\022\024\035\024\027\024\f\022\024\023\017\016: )]TJ 0.035 Tw -4.292 -1.218 Td (\024\f\n\024\021\030\036\027\024 40 \f\n \022\017\001\022\017, \022\031\035\ \034\021\016 \f\024\f\021\024\016\021\036\035\034\027\026, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007)Tj 0 Tw (-)Tj 0.31 Tw T* (\027\036\026\n\023\031\035\016\030\027\024\n \024\021\007\036\035\036 \023\ \030\016\n\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 )Tj 0.242 Tw 0 -1.218 TD [(\f\021\036\027\022\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.646 0 Td [(5 )0.5(\f\n )0.5(\024\021 )0.5(\026\027\024\030\036\022\021\026\035\034\027\024\020\024 )0.5(\023\036\030\036\b\024\007\026 )0.6(\024\023\030\036)]TJ 0 Tw (-)Tj 0.279 Tw -4.646 -1.218 Td (\007\036\035\016\036\021\f\016 \007\036\235\036\022\021 \f\021\036\027\022\ \017 \023\030\016\n\024\005 \022\017\001\022\017 \030\026\n\036\030\026\ \n\017 )Tj 0.041 Tw T* (0,4)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (0,4 \f\n, \023\024\022\030\t\021 \235\017\002\030\017\027\024\n. \211\004\ \017\021\t\r\026\016 \007\026\027\027\t\036 \024\002)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\f\035\036\007\024\r\026\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\035\017\027\017\004\036\f\022\031\033 \022\026\ \030\021\017\027\031, \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\021)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD [(\035\024\032\027\t\n \023\024\022\026\026\027\017\016\n )0.5(\023\026\006\017\036\027\021\031 \r\t\023\024\035\027\036\027\026 \024\023\ \036\030\026\006\017\016: )]TJ 0.174 Tw 0 -1.218 TD [(\r\f\022\030\t\021\017\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.186 0 Td [(\007\030\036\027\017\030\024\r\026\027\017\036 )0.6(\020\027\024\005\027\024\020\024 )0.5(\024\004\026\020\026 )0.6(\n\024\001\024\027\022\017 )]TJ 0.329 Tw -5.186 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017. \230)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\024\022\024\035\026 \024\023\036\030\026\006\017\017: \253\ \246\023\030\024)Tj 0 Tw (-)Tj 0.338 Tw 0 -1.218 TD (\007\024\035\034\027\t\n \035\017\027\036\005\027\t\n \030\026\030\036\ \024\n \r\t\023\024\035\027\036\027\024 \001\017\030\024\022\024\036 )Tj 0.084 Tw 0 -1.218 TD (\030\026\f\f\036\004\036\027\017\036 \022\024\032\017 \n\024\001\024\027\ \022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \027\036\017\n\036\027\036\027\027\t\b )Tj 0.252 Tw 0 -1.218 TD (\021\022\026\027\036\005, \023\024\035\031\004\036\027\024 \007\024)Tj /Span<>> BDC ( )Tj EMC (100 \n\035 \235\017\002\030\017\027\024\027\024-\020\027\024\005\027\024\ \020\024 )Tj 0.183 Tw 0 -1.218 TD [(\024\021\007\036\035\016\036\n\024\020\024 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.465 0 Td [(\017\b\024\030\024\027\t\n )0.6(\026\023\026\b\024\n. )0.5(\221\022\026\027\017 )0.6(\n\024\001\024\027\022\017 )]TJ 0.062 Tw -6.465 -1.218 Td (\027\036\022\030\024\021\017\004\036\f\022\017 \017\n\036\027\036\027\t\ , \021\031\f\022\035\024\020\024 \021\036\n\027\024\020\024 \006\r\036\021\ \026, \r\024)Tj 0 Tw (-)Tj 0.088 Tw 0 -1.218 TD [(\007\016\027\017\f\021\t\036. )0.5(\222\022\036\035\036\021\017\030\024\r\026\027\t )0.5(\024\002\026 \016\017\004\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\036\n\036\027\027\t\036 \022\026)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\027\026\021\017\022\017, \023\030\017\027\026\027\t \032\017\027\036\f\ \023\024\f\024\002\027\t\n\017. \203\036\022\030\024\021\017\004\036\f\022\ \017\005 )Tj 0.059 Tw 0 -1.218 TD (\023\030\024\006\036\f\f \030\026\f\023\030\024\f\021\030\026\027\016\036\ \021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\034, \022)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD (\027\036\005 \f\021\036\027\022\036 \027\017\032\027\036\026\n\023\031\035\ \016\030\027\024\020\024 \024\021\007\036\035\026 \023\030\016\n\024\005\ \022\017\001\022\017. )Tj -0.023 Tw T* (\203\036\022\030\024\021\017\004\036\f\022\017 \017\n\036\027\036\027\027\ \026\016 \022\035\036\021\004\026\021\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\032\026 \n\024\001\024\027\022\017 )Tj 0.111 Tw 0 -1.218 TD (\017\f\f\036\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \007\024\030\024\r\t\b \021\022\026\027\036\ \005. \221\031\026\035\036\021 \030\026\027\t )Tj 0.268 Tw 0 -1.218 TD (\030\026\f\021\r\024\030\026\n\017 \026\027\021\017\f\036\023\021\017\022\ \024\r. \217\t\b\035\024\036 \021\026\n\023\024\027\017\030\024\r\026\027\ \017\036 )Tj 0.001 Tw 0 -1.218 TD [(\030\026\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.996 0 Td [(\030\026\f\021\r\024\030\024\n )0.6(\023\024\r\017\007\024\027-\005\024\007\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.374 0 Td [(\n\026\034\033 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.017 0 Td (\r\024\007\024\030\026\f)Tj 0 Tw (-)Tj 0.134 Tw -18.387 -1.218 Td (\021\r\024\030\017\n\024\005 \024\f\027\024\r\036. \213\007\017\027\017\004\ \027\t\005 \001\024\r \022\024\032\017 \007\035\016 \235\017\022\f\026)Tj 0 Tw (-)Tj 0.283 Tw 0 -1.218 TD (\006\017\017 \023\024\r\016\022\017. \217\036\021\030\024\020\030\026\007\ \027\024\036 \007\017\f\021\026\035\034\027\024\036 \024\021\n\t\r\026\027\ \017\036 )Tj 0 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017\273 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2, 3\).)Tj 0.003 Tw 0 -1.218 TD (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \023\026\006\017\036\027\021 \023\024\035\031\004\ \026\035 \022\024\027)Tj 0 Tw (-)Tj 0.085 Tw 0 -1.218 TD (\f\036\030\r\026\021\017\r\027\031\033 \021\036\030\026\023\017\033 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\n \027\026\023\030\026\r\035\036\027\017\016\ \n: )Tj ET q 303.307 122.57 221.102 205.917 re W n q /GS0 gs 221.1023475 0 0 205.9780881 303.307086 122.5097284 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.118 Tw 9 0 0 9 303.3071 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\027\024\023\025\013\235 \024\023\020\023\r\024 \025\020)Tj /Span<>> BDC ( )Tj EMC (3-\022 \024\r\023\n\022 \033\031\024\f\027 \033\027\032\021\031\b\031 )Tj 0 Tw 0 -1.2 TD (\031\033\027\032\020\023\022\021\025\031\b\031 \021\026\027\213\020\023\027\ \f\017\024\023\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.117 Tw T* [(F)-16(igure )0.6(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Local )0.6(status )0.5(on )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 12.276 0 Td [(3rd )0.5(d)26(ay )0.6(af)-46(ter )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 7.267 0 Td [(f)-43(irst )0.6(surgical )]TJ 0 Tw -19.543 -1.2 Td [(inter)-41.9(v)12.9(entio)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.9403 56.0378 Tm (144)Tj ET endstream endobj 664 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   y!1AQ"aq#2$cs 3BCSr%&'()*456789:DEFGHIJRTUVWXYZbdefghijtuvwxyz!1AQ"aq2BRb#r $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?dn, YqM.̬qI5qyO4@.1;a g>ʞ狈ӟFJ D=zuef*"YBt5o[v {<Ut {neunuHPBf)ه!Ӝz"HHNRb8,m+*x֭sKg?R\F:i=OKCӛ[NmmXXx[V t-;r)nWE SԈ(KsYKQk֕s՛|Y:CH%SK1n(>kYt wS]쩮{8r `Nzb3>"{n b^rS%AvitU`Y_xX)9JjIf(tDh݌v ֣RY֋ 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378.6986 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 5.83 0 0 5.83 42.5197 733.048 Tm (2)Tj 0.023 Tw /Span<>> BDC 10 0 0 10 45.8311 729.718 Tm ( )Tj EMC 0.125 0 Td [(1)112(602 Militar)-30.9(y Clinical Hospital \(Dachnay)21(a\022)-23.2(st., 1)75(0, Rostov)-51.9(-on-Don, 3)58(4406)34.1(4, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 721.0481 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 717.7181 Tm [(St. P)10(eter)20.1(sbur)31(g Medical and social institute \(K)41(ondr)21.1(atie)11(v)10(sky A)20(v)12(e., 7)58.1(2, let)-20(ter A)-31(, St. P)10(eter)20(sbur)31(g, 1)138(9)46(5)35(2)46(7)127(1)69(, Russia\))]TJ /T1_1 1 Tf -0.016 Tw 9 0 0 9 90.7087 699.2141 Tm [(AIM: to p)46(resent a clinical case of e)-15(xtraper)-36.9(itoneal rectal w)12(ound com)16(plicated by F)12(our)-13.9(nier\222)37(s g)11.9(ang)14.1(rene, within the frame)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD [(w)12(ork of multi-stag)12.1(e surgical treatment.)]TJ 0.025 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: patient H., sustained a shrapnel w)12(ound to the per)-37(ineum with non-destructiv)13(e e)-15(xtraper)-37(ito)]TJ 0 Tw (-)Tj 0.062 Tw T* [(neal )0.6(d)26(amag)12(e )0.5(to )0.5(the )0.6(middle )0.6(rectum. )0.5(A)14.1(t )0.5(the )0.5(2nd )0.5(lev)13(el )0.6(of )0.5(medical )0.6(care, )0.6(surgical )0.5(treatment )0.5(included )0.6(end )0.5(sigmostom)11(y)42(, )]TJ 0.031 Tw T* [(sutur)-37(ing of the rectal w)12(ound, bilateral pararectal drainag)12.1(e. Three d)26(ays af)-45.9(ter)61(, a surgical inter)-42(v)13(ention w)13(as per)-34(for)-13.9(med )]TJ 0.007 Tw 0 -1.111 TD [(at )0.5(the )0.5(4th )0.5(lev)13(el )0.5(of )0.5(medical )0.5(care )0.6(for )0.5(the dev)13.1(eloped )0.5(com)16(plication)]TJ /Span<>> BDC ( )Tj EMC 24.63 0 Td [(\227 )0.5(F)12(our)-14(nier\222)37(s )0.5(g)12(ang)14(rene. )0.5(On )0.5(the )0.5(14th )0.5(d)26(ay)42(, )0.5(the )0.5(patient )]TJ 0.023 Tw -24.63 -1.111 Td [(w)13(as discharg)12.1(ed for outpatient treatment.)]TJ 0.065 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: this )0.5(clinical case )0.5(show)12(ed that the end colostom)11.1(y in case of )0.5(non-destructiv)13(e e)-15(xtraper)-37(itoneal rectal injur)-42.9(y )]TJ 0.07 Tw T* [(became the reason for refusing to per)-34(for)-13.9(m an im)16(por)-40(tant element of the 4D concep)13(t)]TJ /Span<>> BDC ( )Tj EMC [(\227 anteg)14(rade distal w)13(ashout. )]TJ 0.056 Tw T* [(Thus, the )0.5(unsanitized )0.5(disconnected )0.5(section )0.5(of )0.5(the rectum )0.5(most lik)17.1(ely became the source of a for)-13.9(mid)26(able com)16(plica)]TJ 0 Tw (-)Tj 0.005 Tw T* (tion)Tj /Span<>> BDC ( )Tj EMC [(\227 F)12(our)-13.9(nier\222)37(s g)12(ang)14(rene. In addition, sutur)-36.9(ing the defect of the rectal w)13(all in this clinical case w)13(as no)13(t a p)46(r)-36.9(ior)-37(ity )]TJ 0.048 Tw T* [(element of the 4D concep)13(t, and routine pararectal drainag)12.1(e did no)13(t hav)13(e a signif)-43(icant im)16(pact on the p)45.9(rev)13(ention of )]TJ 0.023 Tw T* [(infectious com)16(plications.)]TJ 0.007 Tw T* [(C)21(ON)22(CLUSION: e)-15(xtraper)-36.9(itoneal rectal w)12(ounds are associated with a high r)-37(isk of dev)13(eloping life-threatening com)16(plica)]TJ 0 Tw (-)Tj 0.052 Tw 0 -1.111 TD [(tions. Surgical treatment of this categor)-43(y of victims at v)16(ar)-36.9(ious stag)12(es of medical ev)16(acuation should be based on a )]TJ 0.006 Tw 0 -1.111 TD [(personalized app)46(roach, depending on the nature of the injur)-42.9(y)42(, the patient\222)37(s condition, the e)-15(xper)-37(ience of the medical )]TJ -0.015 Tw T* [(staf)-40(f, and the medical tactical situation. Despite the dif)-40(f)-43(iculties in continuity betw)12(een the stag)12(es of medical ev)16(acua)]TJ 0 Tw (-)Tj -0.032 Tw T* [(tion in the system of multi-stag)12.1(e surgical treatment, timely diagnosti\024s and treatment of com)16(plications can minimize )]TJ 0.023 Tw T* [(the conseq)14.1(uences of combat surgical trauma.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 503.9449 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc -0.026 Tw 4.948 0 Td [( F)12(our)-14(nier\222)37(s g)12(ang)14(rene; necro)13(tizing sof)-46(t tissue infection; e)-15(xtraper)-37(itoneal rectal injur)-36.9(ies; gunsho)13(t w)12(ound; multi-stag)12.1(e surgical treatment.)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.05 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.059 Tw 6.494 0 Td [( E)-25.2(s)-22.9(e)-18(l)-23.7(e)-15.8(v)-51.8(i)-5(c)-10.2(h)]TJ /Span<>> BDC ( )Tj EMC [(R)-21.4(.)40.6(V)39.7(.)-23.5(, S)-27.1(a)-9.6(m)-12.4(o)-15.2(k)-16.7(h)-14.1(i)-3.1(n)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-9.8(I)-10.3(.)-23.5(, A)-11.7(l)-16.7(i)-3.2(m)-12.4(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(P)107.7(.)-23.9(A)-23(.)-23.5(, B)-16.4(a)-11.4(l)-23.3(u)-7.6(r)-30.8(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)40.6(V)39.7(.)-23.5(, R)-6.5(u)-7(m)-15.4(y)-24.2(a)-7.6(n)-17.3(t)-48.9(s)-22.9(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-1.9(N)-2.8(.)-23.5(, S)-12.1(u)-7.6(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-22.9(. M)-5.7(u)-8.4(l)-15.3(t)-46.3(i)-7.3(s)-29.3(t)-36.8(a)-10.8(g)-14.4(e s)-8.8(u)-7.6(r)-16.7(g)-28.8(i)-5(c)-21.5(a)-11.4(l t)-30.8(r)-19.1(e)-13(a)-18.1(t)-26.2(m)-16.5(e)-11.5(n)-17.3(t)23( )]TJ 0.045 Tw -6.499 -1.2 Td [(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(v)-51.8(i)-5(c)-41.4(t)-46.3(i)-3.1(m w)-45.7(i)-15.8(t)-26.1(h a)]TJ /Span<>> BDC ( )Tj EMC [(g)-9.5(u)-5(n)-11.2(s)-8.8(h)-10.9(o)-15.8(t w)-13.5(o)-13.3(u)-5(n)-14.5(d o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e e)-33.1(x)-44.8(t)-30.8(r)-30.8(a)-8.8(p)-24.7(e)-12.1(r)-56.3(i)-15.8(t)-21.9(o)-9.2(n)-16.1(e)-13(a)-11.4(l p)-20(a)-10.2(r)-59.7(t o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e r)-19.1(e)-19.1(c)-41.5(t)-22.2(u)-7(m c)-6.5(o)-9.2(m)-5.2(p)-20.1(l)-16.7(i)-5(c)-21.5(a)-18.2(t)-24.7(e)-21(d b)-20(y F)-21(o)-13.3(u)-7.6(r)-35.9(n)-14(i)-11(e)-12.1(r)-63.5(\241)20.6(s g)-8.1(a)-7.6(n)-11.9(g)-13.5(r)-19.1(e)-11.4(n)-16.2(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)12.5(4)-14.1(2)9.8(\226)50.8(1)12.5(4)-35(8)-11.1(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.6(s)-8.1(:)2(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.4(-)41.3(7)10.7(55)-9(6)-26.7(-)9.8(2)-9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.1(1)26.9(-)55.1(1)12.5(4)-14.1(2)12.1(-)55.1(1)12.5(4)-35(8)]TJ /T1_2 1 Tf 0.01 Tc 0.005 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.01 Tw 10.551 0 Td ( \036\024\027\f\027\021\022\007 \206\031\026\020\025 \211\f\020\030\022\026\ \022\032\031\021\022\007, \214\216\221\211\217\210 \211\217 \253\211\031\ \027\025\025\031-\026\027\030\022\006\022\025\024\n\020\t \020\n\020\030\ \027\026\022\t \022\026\027\025\022 \205.\215.)Tj /Span<>> BDC ( )Tj EMC (\202\022\032\031\021\020\273 \215\022\025\022\024\023\027\032\024\023\021\ \020 )Tj 0.177 Tw -10.556 -1.2 Td (\031\240\031\032\031\025\013 \206\031\024\024\022\235\024\n\031\235 \214\ \027\030\027\032\020\006\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\003\n\020\030\027\026\022\n\020 \035\027\240\027\030\027\021\020, \030.\ )Tj /Span<>> BDC ( )Tj EMC (6, \205\020\025\n\023-\004\027\023\027\032\240\r\032\b, \206\031\024\024\ \022\t, 194044; \023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(911\) 128-21-05; \027-mail: )Tj 0 Tw 0 -1.2 TD (r_eselevich@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.005 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.01 Tw 14.025 0 Td [( Eselevich R)19(oman Vladimirovich, Militar)-42.9(y Medical Academ)11(y named af)-46(ter S.M.)]TJ /Span<>> BDC ( )Tj EMC [(Kirov)63.1(, Academica Lebedev)16.1(a st., 6, )]TJ 0.023 Tw -14.03 -1.2 Td [(Saint P)15(etersburg, R)22(ussia, 194044; tel.:)]TJ /Span<>> BDC ( )Tj EMC (+7 \(911\) 128-21-05; e-mail: r_eselevich@mail.ru)Tj 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 10.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 10.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 322.9559 Tm [(\026\027)10(\024)-10(\224)62(\026)-10(\r\237\022\037\032\024\237)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.157 Tw 10 0 0 10 42.5197 298.5999 Tm [(\221\026\022\021\017\022\026 \b\017\030\031\030\020\017\004\036\f\022\024\ \005 )0.5(\023\024\n\024\013\017 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\b )Tj 0.155 Tw 0 -1.218 TD (\030\026\027\036\027\017\016\b \023\030\016\n\024\005 \022\017\001\022\017\ \(\200\002\217\215\025\) \016\r\035\016\036\021\f\016 \026\022\021\031\026\ \035\034)Tj 0 Tw (-)Tj 0.211 Tw T* (\027\024\005 \023\030\024\002\035\036\n\024\005 \f\024\r\030\036\n\036\027\ \027\t\b \r\024\036\027\027\t\b \022\024\027\235\035\017\022\021\024\r. \ )Tj -0.003 Tw T* (\204\036\021\024\007\t \035\036\004\036\027\017\016 \030\026\027\036\027\ \017\005 \023\030\016\n\024\005 \022\017\001\022\017 \026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \004\036\n )Tj 0.375 Tw T* [(\f\021\024\035\036\021\027\017\005 \023\036\030\017\024\007 )0.5(\220\r\024\035\033\006\017\024\027\017\030\024\r\026\035\017 \024\021 \r\ \t\032\017\007\026)]TJ 0 Tw (-)Tj 0.077 Tw T* [(\021\036\035\034\027\024\005 )0.6(\021\026\022\021\017\022\017 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 8.395 0 Td [(\002\024\035\036\036 )0.5(\026\022\021\017\r\027\024\020\024 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )]TJ 0.275 Tw -8.395 -1.218 Td (\023\024\007\b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\026\002\024\021\022\017 4D-\022\024\027\006\036\023\006\017\ \017, \r\022\035\033\004\026\033\013\036\005 )Tj 0.159 Tw T* [(\004\036\021\t\030\036 \024\f\027\024\r\027\t\b \220\035\036\n\036\027\021\ \026: di)-15.9(ver)-10(sion)]TJ /Span<>> BDC ( )Tj EMC (\227 \024\021\r\036\007\036\027\017\036, )Tj 0.515 Tw T* [(debr)-37(idement)]TJ /Span<>> BDC ( )Tj EMC [(\227 \b\017\030\031\030\020\017\004\036\f\022\026\016 )0.5(\024\002\030\026\002\024\021\022\026, dr)-33(ain)]TJ 0 Tw (-)Tj 0.143 Tw T* [(a)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(\227 \007\030\036\027\017\030\024\r\026\027\017\036, dist)15(al w)-11.9(ashout)]TJ /Span<>> BDC ( )Tj EMC (\227 \007\017\f\021\026\035\034\027\024\036 )Tj 0.209 Tw T* (\024\021\n\t\r\026\027\017\036. \216\017\030\031\030\020\017\004\036\f\022\ \017\036 \023\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \023\024)Tj 0 Tw (-)Tj T* (\f\021\030\026\007\026\r\001\017\b \f)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \007\024\f\021\026\021\024\004\027\024 \030\026\027\ \024\030\024\007\027\t [5\2268].)Tj 0.074 Tw T* (\200 \f\017\f\021\036\n\036 \035\036\004\036\002\027\024-\220\r\026\022\031\ \026\006\017\024\027\027\024\020\024 \024\002\036\f\023\036\004\036\027\017\ \016 \r\024)Tj 0 Tw (-)Tj 0.109 Tw T* (\005\f\022 \r\t\007\036\035\016\033\021 5 \031\030\024\r\027\036\005 \024\ \022\026\026\027\017\016 \n\036\007\017\006\017\027\f\022\024\005 \023\024\ )Tj 0 Tw (-)Tj 0.438 Tw T* (\n\024\013\017 \(\211\204\215\). \025\r\026\035\017\235\017\006\017\030\024\ \r\026\027\027\031\033 \b\017\030\031\030\020\017\004\036\f\022\031\033 \ )Tj 0.187 Tw T* (\023\024\n\024\013\034 \023\024\f\021\030\026\007\026\r\001\017\005 \023\ \024\035\031\004\026\036\021, \027\026\004\017\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\026 2 )Tj 0.226 Tw T* (\211\204\215, \022\024\021\024\030\t\005 \004\026\013\036 \r\f\036\020\024\ \n\026\022\f\017\n\026\035\034\027\024 \023\030\017\002\035\017\032\036\ \027 )Tj 0.114 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \023\030\024\r\036\007\036\027\017\016 \002\024\036\r\t\b \ \007\036\005\f\021\r\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\031)Tj 0 Tw (-)Tj 0.362 Tw T* [(\036\021\f\016 )0.5(\024\023\030\026\r\007\026\027\024 )0.6(\024\020\030\026\027\017\004\036\027\027\t\n\017 )0.6(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\n\017 )]TJ 0.445 Tw 23.244 24.356 Td (\r\024\n\024\032\027\024\f\021\016\n\017. \003\026\007\026\004\036\005 \ \007\026\027\027\024\020\024 \220\021\026\023\026 \016\r\035\016\036\021\ \f\016 )Tj 0.133 Tw T* (\f\024\b\030\026\027\036\027\017\036 \032\017\027\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \022\024\027\006\036\023\006\017\017 \n\027\024\020\ \024\220\021\026\023)Tj 0 Tw (-)Tj 0.136 Tw T* (\027\024\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036\027\017\016 \007\024\023\031\f\022\026\036\021\f\016 \024\022\ \026\026\027\017\036 )Tj 0.085 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\027\024\n \024\002\255\036\n\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.419 Tw T* [(\r\017\f\017\n\024\f\021\017 \024\021 \024\023\036\030\026\021\017\r\027\ \024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\n\036\007\017\022\024-\021\026\022\021\017\004\036\f\022\024\005 )Tj 0.199 Tw T* (\024\002\f\021\026\027\024\r\022\017 [4,7]. \003\026\007\026\004\026 \024\ \022\026\026\027\017\016 \017\f\004\036\030\023\t\r\026\033\013\036\005\ )Tj 0.302 Tw T* (\023\024\n\024\013\017 \024\021\r\036\007\036\027\026 \220\021\026\023\026\ \n \f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\024\005 \b\017\ )Tj 0 Tw (-)Tj 0.267 Tw T* [(\030\031\030\020\017\004\036\f\022\024\005 )0.5(\023\024\n\024\013\017 \(3, 4, )0.5(5 \211\204\215\), )0.5(\b\026\030\026\022\021\036\030\017\031\033)]TJ 0 Tw (-)Tj 0.363 Tw T* [(\013\017\n\f\016 )0.6(\r\t\f\024\022\024\005 )0.5(\024\f\027\026\013\036\027\027\024\f\021\034\033 )0.5(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\n\017 )]TJ 0.184 Tw T* (\017\027\f\021\030\031\n\036\027\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \002\035\026\020\024\023\030\017\016\021\027\024\005\ \n\036\007\017\022\024-\021\026\022)Tj 0 Tw (-)Tj T* (\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\024\005 \ [4].)Tj 0.262 Tw T* (\206\026\027\020\030\036\027\026 \205\031\030\027\034\036 \(\206\205\))Tj /Span<>> BDC ( )Tj EMC (\227 \235\024\030\n\026 \027\036\022\030\024\021\017\017\030\031\033\013\ \036)Tj 0 Tw (-)Tj 0.236 Tw T* (\020\024 \235\026\f\006\017\017\021\026 \023\024\035\017\n\017\022\030\024\ \002\027\024\005 \220\021\017\024\035\024\020\017\017, \023\030\024\016\r\ \035\016\033)Tj 0 Tw (-)Tj 0.191 Tw T* (\013\026\016\f\016 \002\t\f\021\030\024 \023\030\024\020\030\036\f\f\017\ \030\031\033\013\036\005 \017\027\235\036\022\006\017\036\005 \021\022\026\ \027\036\005 )Tj 0.317 Tw T* [(\023\030\024\n\036\032\027\024\f\021\017, \020\036\027\017\021\026\035\017\ \005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017\ . )Tj 0.148 Tw T* (\232\026\013\036 \020\026\027\020\030\036\027\026 \n\024\001\024\027\022\ \017 \016\r\035\016\036\021\f\016 \r\021\024\030\017\004\027\024\005 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.175 Tw T* (\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\017\027\235\036\022\006\017\016\n \026\027\024\030\036\022\021\026\035\034\ \027\024\005 \024\027\t, \031\030\024\020\036)Tj 0 Tw (-)Tj 0.31 Tw T* [(\027\017\021\026\035\034\027\024\020\024 )0.6(\021\030\026\022\021\026, )0.5(\f\r\016\026\027\027\t\n )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 14.591 0 Td [(\n\036\f\021\027\024\005 )0.5(\021\030\026\r\n\024\005, )]TJ 0.334 Tw -14.591 -1.218 Td (\024\023\036\030\026\021\017\r\027\t\n\017 \r\n\036\001\026\021\036\035\034\ \f\021\r\026\n\017 \017\035\017 \026\002\024\035\036\r\026\027\017\016)Tj 0 Tw (-)Tj 0.23 Tw T* (\n\017 \n\024\004\036\r\t\r\024\007\016\013\017\b \023\031\021\036\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \024\021\007\ \036)Tj 0 Tw (-)Tj 0.216 Tw T* (\035\026 \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\ \020\024 \021\030\026\022\021\026 [1,2]. \206\205 \016\r\035\016\036\021\ \f\016 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 707.7183 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 698.791 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5646 56.0378 Tm (143)Tj ET endstream endobj 659 0 obj [675 0 R] endobj 660 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 247.8104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 247.8104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 210.6026 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 210.6026 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-142-148)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 82.1531 695.3259 Tm [(\235\t\025\013)10(\025)21(\237\026)11(\017\224\t\025\004 \220\n\005\002\005\013\n\225\004\016\r)10(\025\004 \020\004\225\004\t\n\004 \224\025\016)-10(\026\005\017\202\017\b\204\004\013)10(\025 )]TJ 0.688 -1.105 Td [(\016\022)-23.3(\025\013\t\004\016)-9.9(\026\005\004\020\200\t\217\024 \005\017\t\004\t\n\004\024 \b\t\004\255\005\ \206\204\n\t\t\025\013)10(\025 \025\026)11(\202\004\020\017 )]TJ 0.581 -1.105 Td [(\224\005\213\024\025\221 \r\n\204\r\n, \025\016)-10(\020\025\226\t\242\t\t\217\024 \013)10(\017\t\013\005\004\t\025\221 \210\002\005\t\200\004)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\240\016\004\020\004\b\n\225\022)-23.2(\033)124(.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 146.4413 633.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 157.7619 628.822 Tm [(, \001\017\024\025\220\n\t\022)-23.2(\036.\030.)]TJ 0 Tw 8.162 0 0 8.162 250.1408 633.484 Tm (2)Tj 0.023 Tw 14 0 0 14 254.7768 628.822 Tm [(, \f)-21(\020\n\024\025\b\022)-23.2(\034.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 337.1315 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 341.7674 628.822 Tm [(, \006\017\020\206\005\017\022)-23.2(\036.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 424.9065 633.484 Tm [(1,)-69(3)]TJ 0 Tc 0 Tw 14 0 0 14 436.2271 628.822 Tm (, )Tj -26.097 -1.143 Td [(\033)-21(\002\024\213\t\004\b\022)-23.2(\021.\007.)]TJ 8.162 0 0 8.162 152.587 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 157.223 612.822 Tm [(, \001\002\005\025\b\022)-23.2(\201.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 231.1081 617.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 598.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 595.1527 Tm [(\210\031\006\021\036)20(\227 \021\036 \253\021\025\004\t\t\025-\024\004\202\n\n\t\016\r\017\213\ \017\r\017\202\004\024\n\213 \n\024\004\t\n \001.\235.\022)-23.2(\037)19.9(\n\005\025\b\017\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\ \n\n \(\002\020.\022)-23.3(\f\r\017\202\004\024\n\r\017 )]TJ -0.331 -1.2 Td [(\035\004\255\004\202\004\b\017, \202.\022)-23.3(6\223, \013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)80(40)25(44, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 574.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 571.1527 Tm [(\210\031\037\227 \2531)112(602 \021\025\004\t\t\217\221 \r)-10(\020\n\t\n\225\004\016\r\n\221 \013)10.1(\025\016\224\n\026)11(\017\020\200\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\n\n\ \(\002\020.\022)-23.3(\201\017\225\t\017\213, \202.\022)-23.3(1)75(0, \033\025\016)-10(\026)11(\025\b\016\r\017\213 )]TJ -0.331 -1.2 Td [(\025\255\020\017\016)-10(\026\200, \013)62(.\022)-23.3(\033\025\016)-10(\026)11(\025\b-\t\017)-84(-)-52(\201\025\t\002)31.1(, 3)58(4406)34(4, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 550.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 547.1528 Tm [(\215\036)20(\227\021\036 \253\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)10.1(\016\r\n\221 \024\004\202\n\r)10(\025-\016\025\n\017\020\200\t\217\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026\273 \(\224\005-)-41.9(\026 \037)31(\025\t\202\005\017\026\200\004\b\016\r\n\221, \202.\022)-23.3(7)58(2, \020\n\026)11(\004\005 \f)-52(, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)46(5)35(2)46(7)127(1)69(, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.036 Tw 9 0 0 9 119.0551 516.6489 Tm (\037\036\035\034: \033\032\031\030\027\026\031\025\024\023\032\022\032\031\ \021\020\023\017 \n\f\022\025\022\007\027\024\n\031\027 \025\020\240\f\005\ \030\027\025\022\027 \030\022\020\b\025\031\024\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\t \021\025\027\240\032\005\213\022\025\025\031\b\031\ \032\020\025\027\025\022\t \033\032\t)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\026\031\235 \n\022\213\n\022, \031\024\f\031\255\025\027\025\025\031\b\031\ \b\020\025\b\032\027\025\031\235 \214\r\032\025\017\027, \021)Tj /Span<>> BDC ( )Tj EMC (\032\020\026\n\020\200 \026\025\031\b\031\204\023\020\033\025\031\b\031 \ \200\022\032\r\032\b\022\007\027\024\n\031\b\031 \f\027\007\027\025\022\t\ .)Tj 0.062 Tw 0 -1.111 TD (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \033\020\006\022\027\025\023 \225. \033\031\f\r\007\ \022\f \031\024\n\031\f\031\007\025\031\027 \032\020\025\027\025\022\027\ \033\032\031\026\027\255\025\031\024\023\022 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\024\023\032\r\n\023\022\021\025\013\026 \021\025\027\240\ \032\005)Tj 0 Tw (-)Tj 0.02 Tw 0 -1.111 TD (\213\022\025\025\013\026 \033\031\021\032\027\255\030\027\025\022\027\026\ \024\032\027\030\025\027\020\026\033\r\f\t\032\025\031\b\031 \031\023\030\ \027\f\020 \033\032\t\026\031\235 \n\022\213\n\022. \001\020)Tj /Span<>> BDC ( )Tj EMC (2 \r\032\031\021\025\027 \031\n\020\016\020\025\022\t \026\027\030\022\006\ \022\025\024\n\031\235 \033\031\026\031)Tj 0 Tw (-)Tj 0.159 Tw T* (\212\022 \021\013\033\031\f\025\027\025\031 \031\033\027\032\020\023\022\ \021\025\031\027 \f\027\007\027\025\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\236\027\026\027: \203\031\032\026\022\032\031\021\020\025\022\027\ \n\031\025\006\027\021\031\235 \024\022\b\026\031\024\023\031\026\013, \ \r\213\022\021\020\025\022\027 \030\027\203\027\n\023\020 )Tj 0.055 Tw T* (\033\032\t\026\031\235 \n\022\213\n\022, \240\022\f\020\023\027\032\020\f\ \017\025\031\027 \033\020\032\020\032\027\n\023\020\f\017\025\031\027 \030\ \032\027\025\022\032\031\021\020\025\022\027. \205\033\r\024\023\t 3 \024\ \r\023\031\n \033\031\024\f\027 \031\033\027\032\020\006\022\022 \025\020\ )Tj /Span<>> BDC ( )Tj EMC (4 \r\032\031\021\025\027 )Tj 0.053 Tw T* (\031\n\020\016\020\025\022\t \026\027\030\022\006\022\025\024\n\031\235 \ \033\031\026\031\212\022 \021\013\033\031\f\025\027\025\031 \031\033\027\ \032\020\023\022\021\025\031\027 \021\026\027\213\020\023\027\f\017\024\023\ \021\031 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r \032\020\016\021\022\021\213\027\b\031\024\t \031\ \024\f\031\255\025\027)Tj 0 Tw (-)Tj 0.023 Tw T* (\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 \b\020\025\b\032\027\025\013 \214\r\032\025\017\027. \001\020)Tj /Span<>> BDC ( )Tj EMC (14-\027 \024\r\023\022 \033\020\006\022\027\025\023 \021\013\033\022\024\ \020\025 \025\020)Tj /Span<>> BDC ( )Tj EMC (\020\026\240\r\f\020\023\031\032\025\031\027 \f\027\007\027\025\022\027.\ )Tj 0.103 Tw T* (\206\036\207\210\035\034\003\201: \031\033\022\024\020\025\025\013\235\ \n\f\022\025\022\007\027\024\n\022\235 \024\f\r\007\020\235 \033\031\n\020\ \016\020\f, \007\023\031 \203\031\032\026\022\032\031\021\020\025\022\027\ \n\031\025\006\027\021\031\235 \024\022\b\026\031\024\023\031\026\013 \033\ \032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027)Tj 0 Tw (-)Tj 0.251 Tw T* (\024\023\032\r\n\023\022\021\025\031\026 \021\025\027\240\032\005\213\022\ \025\025\031\026 \032\020\025\027\025\022\022 \033\032\t\026\031\235 \n\022\ \213\n\022 \024\023\020\f\031 \033\032\022\007\022\025\031\235 \031\023\n\ \020\016\020 \031\023 \021\013\033\031\f\025\027\025\022\t \021\020\255\025\ \031\b\031 )Tj -0.019 Tw T* (\204\f\027\026\027\025\023\020 4D-\n\031\025\006\027\033\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 \020\025\023\027\b\032\020\030\025\031\b\031 \030\022\024\023\020\f\ \017\025\031\b\031 \031\023\026\013\021\020\025\022\t. \020\n\022\026 \031\ \240\032\020\016\031\026, \025\027\024\020\025\022\032\031\021\020\025\025\ \013\235 \031\023\n\f\005)Tj 0 Tw (-)Tj 0.179 Tw 0 -1.111 TD (\007\027\025\025\013\235 \r\007\020\024\023\031\n \033\032\t\026\031\235\ \n\022\213\n\022, \021\027\032\031\t\023\025\027\027 \021\024\027\b\031\ , \t\021\022\f\024\t \022\024\023\031\007\025\022\n\031\026 \032\020\016\ \021\022\023\022\t \b\032\031\016\025\031\b\031 \031\024\f\031\255\025\027\ \025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.11 Tw 0 -1.111 TD [(\b\020\025\b\032\027\025\013 \214\r\032\025\017\027. )0.5(\202\032\031\026\027 \023\031\b\031, \r\213\022\021\020\025\022\027 )0.5(\030\027\203\027\n\023\020 \024\023\027\025\n\022 \033\032\t\026\031\235\ )0.5(\n\022\213\n\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\030\020\025\025\031\026 \n\f\022\025\022\007\027\024\n\031\026 \024\f\r\ \007\020\027 \025\027 )Tj -0.023 Tw T* (\t\021\f\t\f\031\024\017 \033\032\022\031\032\022\023\027\023\025\013\026\ \204\f\027\026\027\025\023\031\026 4D-\n\031\025\006\027\033\006\022\022\ , \020)Tj /Span<>> BDC ( )Tj EMC (\032\r\023\022\025\025\031\027 \021\013\033\031\f\025\027\025\022\027 \033\ \020\032\020\032\027\n\023\020\f\017\025\031\b\031 \030\032\027\025\022\032\ \031\021\020\025\022\t )Tj 0.023 Tw T* (\025\027 \031\n\020\016\020\f\031 \016\025\020\007\022\023\027\f\017\025\ \031\b\031 \021\f\022\t\025\022\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\203\022\f\020\n\023\022\n\r \032\020\016\021\022\023\022\t \ \022\025\203\027\n\006\022\031\025\025\013\200 \031\024\f\031\255\025\027\ \025\022\235.)Tj 0.039 Tw T* (\207\003\202\035\224\232\036\001\002\036: \021\025\027\240\032\005\213\022\ \025\025\013\027 \032\020\025\027\025\022\t \033\032\t\026\031\235 \n\022\ \213\n\022 \024\031\033\032\t\255\027\025\013 \024)Tj /Span<>> BDC ( )Tj EMC (\021\013\024\031\n\022\026 \032\022\024\n\031\026 \032\020\016\021\022\023\ \022\t \255\022\016\025\027\r\b\032\031\255\020)Tj 0 Tw (-)Tj 0.028 Tw T* (\005\212\022\200 \031\024\f\031\255\025\027\025\022\235. \225\022\032\r\032\ \b\022\007\027\024\n\031\027 \f\027\007\027\025\022\027 \030\020\025\025\ \031\235 \n\020\023\027\b\031\032\022\022 \033\031\024\023\032\020\030\020\ \021\213\022\200 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \204\023\020\033\020\200 \026\027\030\ \022\006\022\025)Tj 0 Tw (-)Tj 0.053 Tw T* (\024\n\031\235 \204\021\020\n\r\020\006\022\022 \030\031\f\255\025\031 \031\ \024\025\031\021\013\021\020\023\017\024\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\024\031\025\022\203\022\006\022\032\031\021\020\025\025\031\ \026 \033\031\030\200\031\030\027, \n\020\n \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \200\020\032\020\n\ \023\027\032\020 )Tj -0.009 Tw T* (\032\020\025\027\025\022\t, \024\031\024\023\031\t\025\022\t \033\020\006\ \022\027\025\023\020, \031\033\013\023\020 \026\027\030\022\006\022\025\024\ \n\031\b\031 \033\027\032\024\031\025\020\f\020, \023\020\n \022)Tj /Span<>> BDC ( )Tj EMC (\031\023 \026\027\030\022\n\031-\023\020\n\023\022\007\027\024\n\031\235\ \031\240\024\023\020\025\031\021\n\022. )Tj 0.052 Tw T* (\001\027\024\026\031\023\032\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\255\025\031\024\023\022 \031\240\027\024\033\027\007\027\025\022\ \t \033\032\027\027\026\024\023\021\027\025\025\031\024\023\022 \026\027\ \255\030\r \204\023\020\033\020\026\022 \026\027\030\022\006\022\025\024\ \n\031\235 \204\021\020\n\r\020\006\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\023\027\026\027 )Tj 0.257 Tw 0 -1.111 TD (\026\025\031\b\031\204\023\020\033\025\031\b\031 \200\022\032\r\032\b\022\ \007\027\024\n\031\b\031 \f\027\007\027\025\022\t, \024\021\031\027\021\032\ \027\026\027\025\025\020\t \030\022\020\b\025\031\024\023\022\n\020 \022\ )Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\027 \031\024\f\031\255\025\027\025\022\235 \033\031\ \016\021\031\f\t\005\023 )Tj 0.023 Tw 0 -1.111 TD (\026\022\025\022\026\022\016\022\032\031\021\020\023\017 \033\031\024\f\027\ \030\024\023\021\022\t \240\031\027\021\031\235 \200\022\032\r\032\b\022\ \007\027\024\n\031\235 \023\032\020\021\026\013.)Tj /T1_2 1 Tf 0.01 Tc 0.079 Tw 8 0 0 8 70.9061 291.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.084 Tw 8.554 0 Td ( \b\020\025\b\032\027\025\020 \214\r\032\025\017\027; \025\027\n\032\031\ \023\022\016\022\032\r\005\212\020\t \022\025\203\027\n\006\022\t \026\t\ \b\n\022\200 \023\n\020\025\027\235; \021\025\027\240\032\005\213\022\025\ \025\013\027 \033\031\021\032\027\255\030\027\025\022\t \033\032\t\026\031\ \235 \n\022\213\n\022; \031\b\025\027)Tj 0 Tw (-)Tj 0.023 Tw -8.559 -1.2 Td (\024\023\032\027\f\017\025\031\027 \032\020\025\027\025\022\027; \026\025\ \031\b\031\204\023\020\033\025\031\027 \200\022\032\r\032\b\022\007\027\024\ \n\031\027 \f\027\007\027\025\022\027)Tj /T1_2 1 Tf 0.01 Tc 0.015 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.02 Tw 10.398 0 Td ( \020\021\023\031\032\013 \030\027\n\f\020\032\022\032\r\005\023 \031\023\ \024\r\023\024\023\021\022\027 \t\021\025\013\200 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\023\027\025\006\022\020\f\017\025\013\200 \n\031\025\203\f\022\n\ \023\031\021 \022\025\023\027\032\027\024\031\021, \024\021\t\016\020\025\ \025\013\200 \024)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\027\235 )Tj 0.023 Tw -10.403 -1.2 Td (\025\020\024\023\031\t\212\027\235 \024\023\020\023\017\022)Tj /T1_2 1 Tf 0.033 Tc 0.016 Tw 0.005 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.021 Tw 9.189 0 Td ( \213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \222\026\n\024\b\017\027)Tj /Span<>> BDC ( )Tj EMC (\210.\230., \202\035\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\202., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \222\031\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202. \204\027\024\020\024\220\021\026\023\027\024\036 \b\017\030\031\ \030\020\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.036 Tw -9.194 -1.2 Td (\f\022\024\036 \035\036\004\036\027\017\036 \023\024\f\021\030\026\007\026\ \r\001\036\020\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\020\027\036\f\021\030\036\035\034\027\t\n \030\026\027\036\027\017\036\ \n \r\027\036\002\030\033\001\017\027\027\024\020\024 \024\021\007\036\035\ \026 \023\030\016\n\024\005 \022\017\001\022\017, \024\f\035\024\032\027\ \201\027\027\t\n \020\026\027\020\030\036\027\024\005 \205\031\030\027\034\ \036.)23.1( )]TJ /T1_0 1 Tf -0.023 Tw 0 -1.2 TD (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (142\226148. https://doi.org/10.33878/2073-7556-2026-25-1-142-148)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 138.3163 184.4333 Tm [(Multistage sur)31(gical tr)31(eatment of\022)-23.2(a\022)-23.3(victim with )]TJ -1.218 -1.167 Td [(a\022)-23.3(gunsh)11(ot w)10.9(ound of\022)-23.3(th)11(e e)21(xtr)21.1(aperitoneal par)-20(t of\022)-23.3(th)11(e )]TJ 1.469 -1.167 Td [(r)31(ectum complicated b)10(y F)15(ournier\236)63.1(s gangr)31(ene)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 117.9294 Tm [(Roman\022)-23.3(V)62(.\022)-23.2(Esele)11(vich)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 178.589 122.5914 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 189.9096 117.9294 Tm [(, Oleg\022)-23.2(I.\022)-23.3(Samokhin)]TJ 0 Tw 8.162 0 0 8.162 295.4661 122.5914 Tm (2)Tj 0.023 Tw 14 0 0 14 300.1021 117.9294 Tm [(, P)20(av)12(el\022)-23.3(A)-30.9(.\022)-23.3(Alimov)]TJ 0 Tw 8.162 0 0 8.162 397.2309 122.5914 Tm (1)Tj 0.023 Tw 14 0 0 14 401.8669 117.9294 Tm [(, Oleg\022)-23.2(V)62(.\022)-23.3(Balur)21(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 492.9476 122.5914 Tm [(1,)-69(3)]TJ 0 Tc 0 Tw 14 0 0 14 504.2682 117.9294 Tm (, )Tj -30.957 -1.143 Td [(V)31(aler)-31(y\022)-23.2(N.\022)-23.3(Rum)21(y)21(antse)11(v)]TJ 8.162 0 0 8.162 194.8286 106.5914 Tm (1)Tj 0.023 Tw 14 0 0 14 199.4646 101.9294 Tm [(, Dmitrii\022)-23.2(A)-31(.\022)-23.3(Sur)20(ov)]TJ 0 Tw 8.162 0 0 8.162 296.1168 106.5914 Tm (1)Tj 5.83 0 0 5.83 70.8661 87.5901 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 84.2601 Tm [(S.M.\022)-23.3(Kir)20(ov Militar)-30.9(y Medical Academ)21(y \(Akademika Lebede)11(v)10(a\022)-23.2(st., 6J, Saint P)10(eter)20(sbur)31(g, 1)138(9)79.9(40)25.1(44, Russia\))]TJ 0 Tw ( )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 525.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 516.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8528 56.0378 Tm (142)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 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Eur)-32(opean S)-16(o)-16(c)-24(ie)-12(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(op)25(r)-32(o)-16(c)-16(t)17(ol)30.1(o)-16(g)16(y Cor)-23.9(e )]TJ -0.034 Tw -1.296 -1.25 Td [(Outcome se)-12(t for haemor)-23.9(r)-24(hoid)42(al disease: an)]TJ /Span<>> BDC ( )Tj EMC [(inter)-14.9(na)15(t)-32(ional Delphi stud)17(y )]TJ 0.081 Tw T* [(among heal)56(t)-13(hcar)-24(e p)25(r)-32(ofessionals. )]TJ /T1_4 1 Tf 13.475 0 Td (Colorectal Dis)Tj /T1_3 1 Tf (. 2019;21\(5\):570\22680. )Tj 0 Tw -13.475 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.14553)Tj 0 0 0 1 k /GS1 gs -0.015 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bl)-16(a)-17(ck)]TJ /Span<>> BDC ( )Tj EMC [(N. P)40(a)15(t)-32(ient r)-24(epor)-22(ted outcome measur)-24(es could help tr)-33(ansfor)-15.9(m )]TJ 0 Tw -1.296 -1.25 Td [(heal)56(t)-13(hcar)-23.9(e. )]TJ /T1_4 1 Tf 4.794 0 Td (BMJ)Tj /T1_3 1 Tf 0.023 Tw [(. 2013;346:f167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.f167)Tj 0 0 0 1 k /GS1 gs 0.161 Tw -4.794 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(uiper)]TJ /Span<>> BDC ( )Tj EMC (SZ, Kimman)Tj /Span<>> BDC ( )Tj EMC [(ML, V)25(an T)45(ol)]TJ /Span<>> BDC ( )Tj EMC [(RR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(a)15(t)-32(ient r)-24(epor)-22(ted out)]TJ 0 Tw (-)Tj 0.071 Tw -1.296 -1.25 Td [(come measur)-24(e-haemor)-23.9(r)-24(hoid)42(al im)10.1(p)32(a)-17(c)-16(t and sa)15(t)-32(isf)16(a)-17(c)-16(t)-32(ion scor)-24(e \(PROM-)]TJ 0.001 Tw T* [(HIS)17(S\): devel)30.1(opment, r)-24(el)-31(iabil)-30.9(i)-24(t)-10(y and constr)-22(uc)-16(t )0.5(v)-15(al)-31(idi)-24(t)-10(y. )]TJ /T1_4 1 Tf [(Colorectal )0.5(Dis. )]TJ /T1_3 1 Tf 0.023 Tw 29.055 20 Td [(2022;24:992\2269. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16079)Tj 0 0 0 1 k /GS1 gs 0.223 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(er)-38(wee)]TJ /Span<>> BDC ( )Tj EMC [(CB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-15.9(ual)-31(i)-24(t)-10(y cr)-37(i)-24(ter)-37(ia wer)-24(e p)25(r)-32(oposed for measur)-24(e)]TJ 0 Tw (-)Tj 0.181 Tw -1.296 -1.25 Td [(ment p)25(r)-32(oper)-21.9(t)-32(ies of)]TJ /Span<>> BDC ( )Tj EMC [(heal)56(t)-13(h st)15.1(a)14.9(tus quest)-32(ionnair)-23.9(es. )]TJ /T1_4 1 Tf (J Clin Epidemiol.)Tj /T1_3 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2007;60\(1\):34\22642. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.jcl)-30.9(inepi.2006.03.012)]TJ 0 0 0 1 k /GS1 gs 0.196 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(uiper)]TJ /Span<>> BDC ( )Tj EMC [(SZ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al., Engl)-31(ish tr)-33(ansl)-15.9(a)15(t)-32(ion and cr)-32(oss-cul)56(tur)-32.9(al v)-15(al)-30.9(id)42(a)]TJ 0 Tw (-)Tj 0.159 Tw -1.296 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he p)32(a)15(t)-32(ient-r)-24(epor)-22(ted outcome measur)-23.9(ement-haemor)-24(r)-23.9(hoid)42(al )]TJ 0.006 Tc 0.349 Tw T* [(im)10.1(p)32.1(a)-16.9(c)-15.9(t and sa)15.1(t)-31.9(isf)16(a)-16.8(c)-16(t)-31.9(ion scor)-23.9(e \(PROM-HIS)17.1(S\). )]TJ /T1_4 1 Tf [(Colorectal Disease.)6( )]TJ /T1_3 1 Tf 0 Tc 0.023 Tw T* [(2023;25:1671\2261678. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16650)Tj 0 0 0 1 k /GS1 gs 0.118 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(ild)]TJ /Span<>> BDC ( )Tj EMC [(D, G)20(r)-32(ove)]TJ /Span<>> BDC ( )Tj EMC [(A, Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-37(inc)-24(iples of)]TJ /Span<>> BDC ( )Tj EMC [(go)-16(od p)25(r)-33(a)-17(c)-15.9(t)-32(ice for )]TJ 0.052 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 1.635 0 Td [(tr)-33(ansl)-15.9(a)15(t)-32(ion )0.5(and )0.6(cul)56(tur)-32.9(al )0.5(ad)42(apt)15(a)15(t)-32(ion )0.6(p)25(r)-32(o)-16(cess )0.6(for )0.5(p)32(a)15(t)-32(ient-r)-23.9(epor)-22(ted )]TJ 0.069 Tw -1.635 -1.25 Td [(outcomes \(PRO\) measur)-23.9(es: r)-24(epor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ISPOR t)15(ask for)-31.9(ce for tr)-33(ans)]TJ 0 Tw (-)Tj 0.316 Tw T* [(l)-16(a)15(t)-32(ion and cul)56.1(tur)-33(al ad)42(apt)15(a)15(t)-32(ion. )]TJ /T1_4 1 Tf [(V)33(alue Health.)]TJ /T1_3 1 Tf ( 2005;8\(2\):94\226104. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1524-4733.2005.04054.x)Tj 0 0 0 1 k /GS1 gs 0.013 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(ohamad A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC (B, Hon)Tj /Span<>> BDC ( )Tj EMC [(YK, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC (KY. A)Tj /Span<>> BDC ( )Tj EMC [(step-b)12.1(y-step guide t)17(o)]TJ /Span<>> BDC ( )Tj EMC (ques)Tj 0 Tw (-)Tj 0.08 Tw -1.796 -1.25 Td [(t)-32(ionnair)-23.9(e v)-15(al)-31(id)42(a)15(t)-32(ion r)-23.9(esear)-32(ch. K)25(ual)-15.9(a L)35(um)10(pur, Mal)-16(a)15(y)-12.9(sia: Inst)-32(i)-24(tute for )]TJ 0.023 Tw T* [(Cl)-31(inical R)13(esear)-32(ch. )]TJ /T1_4 1 Tf (NIH MY.)Tj /T1_3 1 Tf [( 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.5281/zenod)-15.9(o.6801209)]TJ /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.7397 56.0378 Tm (141)Tj ET endstream endobj 658 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   r!1"AQ#2TaqBRS3Uc$4rs %&'()*56789:CDEFGHIJVWXYZbdefghijtuvwxyz?jEQEQEQEQEQEQEQEQEQEQEQEQEQEQ@j^71N.v88PMp֗W:vHPD(nN0G#.D+FLs*SSYݮ-,KIs6~P#Z_í*·U@INLt`yp+AƼ2S/|Y@=le1H@ 1@FEGqFq[\yp'49!OA8Qql|5 ȂFac[Rʹ A\ӈElSFUR<=]ZGln+3H$FSa; ֶYw&oM 4>##:͆i"ܡ\(8#;;bɣxyk*rHfxe#Y  Ij7YcYRApk]l Kaۡ HStXÇ%KQ#BvJ YX rAk'w!J* !* ~\xo0PBJr dyGjCNuhNlK#͵a;GXQ'~\xI$,Xb+s6Ap1BsgN*˛R3ߝ^_!)x;@y]:=x7ႆA{X8Ll^^,crB0(0|{tC1Ls,ѕY"F ! uuΛ46kr%^oo4su{ %*bKI$ ;WC2@ =pk]o&12s6HPv%TҼcY([nB C |> )J)܌#ls=3^.\7g7-f6=S㷞>Z $2p+p`QDUI,r h%H+9Bߡ=kSIDg/&paے'[_zeE,IcIQ8+x74|JJ( yɭdN4FGpDs7'`פWQ-⩁Qd%C;6zیi^`/7'7NN93f!;RxEt8#* 5s:=U.{c)&=pC.ާ~?pCqrc{qA$o<Gn/%ZUo[b!dH0p3NTہD8/=8ˆ7F" ,ydL^NTRv7ֺwO͂ep0jA[ I<&7* t7q'Gk.؃qb.02OJ.ViD8Z;t##;dT Ktk6#dro/cY5m0cYqq>Fvi xJ .R3,#}=W'xDЉpZ4=͟7JtSmkqkwډ&z8J[[ɘ-ÄMrxod2#*ox9{UdeDF=0Q'YZֱ"(F[ fN+ia7R+q4r%Vq$nan "m=G%gNnNJYb(oD)^CaֽB6Ϩl&X"Uf ;ne.7*'i{/{5V `q"̡d9G1Va9`kYԧ7Z#wxѻ״/0I%̍om4Gnʍ&#r$nM\PVq,I b@cw2 铎q\#k9oJ,jY] yKSVؐF[qDU-gMC' Gh KD##NݍE8c|*j#ڻCjR\xƯFF>iOzm23A(Np;Jb:GP]C䟁-g#V9Q|s̯G »#de/: ?#Ea>d7QHFA*!=<'ü52ܴlC6G߹9kHZ#@R $0u8=Q]O )]G,{=YWyr-feĞ*".tp܅H r$eC8cֵga ܬƼiy8u< !ɢR 低0 s8NOJmq׍0]g"_Wusgp$ݹ7F[+ҤA|qy8q!FI׶GڥJ<3qe&ܧb+bIc&PU&@svG[n/^! 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\r\n\036\001\026\021\036\ \035\034\f\021\r\024 )Tj -0.008 Tw 0 -1.218 TD [(\f\024\024\021\r\036\021\f\021\r\031\036\021 )0.6(\024\032\017\007\026\027\017\016\n )0.6(\023\026\006\017\036\027\021\026 )0.5(\017, )0.5(\021\026\022\017\n )0.6(\024\002\030\026\024\n, )]TJ 0.005 Tw T* (\027\026\f\022\024\035\034\022\024 \024\027 \031\007\024\r\035\036\021\r\ \024\030\036\027 \021\036\n \017\035\017 \017\027\t\n \b\017\030\031\030\ \020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\n \r\n\036\001\026\021\036\035\034\f\021\r\024\n.)Tj -0.012 Tw T* [(\210\030\017\020\017\027\026\035\034\027\t\005 )0.5(\020\024\035\035\026\027\007\f\022\017\005 \024\023\030\024\f\027\017\022\ PROM-HIS)17.1(S \031\032\036 )]TJ 0.14 Tw T* (\002\t\035 \023\030\024\021\036\f\021\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \036\020\024 \023\f\017\b\024\n\036\ \021\030\017\004\036)Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\f\022\017\b \b\026\030\026\022\021\036\030\017\f\021\017\022 \(\f\021\030\ \031\022\021\031\030\027\t\036 \f\r\024\005\f\021\r\026, \027\026\007\036\ \032)Tj 0 Tw (-)Tj 0.15 Tw 0 -1.218 TD (\027\024\f\021\034, \022\024\027\f\021\030\031\022\021\017\r\027\026\016\ \r\026\035\017\007\027\024\f\021\034\), \004\021\024 \027\036\024\002\b\ \024\007\017\n\024 )Tj 0.196 Tw T* (\007\035\016 \021\026\022\024\020\024 \030\024\007\026 \024\023\030\024\f\ \027\017\022\024\r, \023\030\036\007\027\026\027\026\004\036\027\027\t\b\ \007\035\016 )Tj 0.175 Tw T* (\017\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \f\022\030\t\021\t\b \023\036\030\036\n\036\027\ \027\t\b, \021\026\022\017\b \022\026\022 )Tj -0.015 Tw T* (\022\026\004\036\f\021\r\024 \032\017\027\017 \(\r\024\023\030\024\f \212\ 2\) \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\034 \035\036)Tj 0 Tw (-)Tj 0.085 Tw T* (\004\036\027\017\036\n \(\r\024\023\030\024\f \2123\). \211\004\017\021\t\ \r\026\016 \220\021\024\021 \235\026\022\021, \027\026\n\017 \024\032\017\ )Tj 0 Tw (-)Tj 0.058 Tw 0 -1.218 TD (\007\026\035\024\f\034, \004\021\024 \030\031\f\f\022\024\016\t\004\027\ \026\016 \r\036\030\f\017\016 \024\023\030\024\f\027\017\022\026 \f\022\024\ \030\036\036 )Tj 0.264 Tw 0 -1.218 TD (\r\f\036\020\024 \002\031\007\036\021 \017\007\036\027\021\017\004\027\024\ \005 \024\030\017\020\017\027\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\035\034 \032\036 )Tj 0.134 Tw 0 -1.218 TD (\023\024\027\016\021\027\024\005 \007\035\016 \030\024\f\f\017\005\f\022\ \024\020\024 \023\026\006\017\036\027\021\026. \210\007\027\026\022\024 \ \220\021\024 \027\036 )Tj 0.048 Tw T* (\r\f\036\020\007\026 \021\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \r\r\017\007\031 \021\ \024\020\024, \004\021\024 \021\026\030\020\036\021)Tj 0 Tw (-)Tj 0.008 Tw T* (\027\t\005 \016\t\022 \n\024\032\036\021 \023\030\017\r\027\024\f\017\021\ \034 \024\023\030\036\007\036\035\036\027\027\t\036 \022\024\027\021\036\ \022\f\021)Tj 0 Tw (-)Tj 0.09 Tw T* [(\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.757 0 Td [(\f\036\n\026\027\021\017\004\036\f\022\017\036 )0.5(\030\026\035\017\004\017\016, \027\036 )0.5(\f\024\024\021\r\036\021\f\021\r\031\033\013\017\036 )]TJ 0.107 Tw -2.757 -1.218 Td [(\f\n\t\f\035\031 \017/\017\035\017 )0.5(\f\021\030\031\022\021\031\030\036 )0.5(\024\030\017\020\017\027\026\035\026. \200)]TJ /Span<>> BDC ( )Tj EMC 16.332 0 Td (\027\026\001\036\n \f\035\031\004\026\036 )Tj 0.047 Tw -16.332 -1.218 Td [(\017\n\036\027\027\024 )0.5(\220\021\024 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.758 0 Td [(\f\035\031\004\017\035\024\f\034, )0.6(\004\021\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.044 0 Td [(\017\021\024\020\036 )0.5(\023\030\017\r\036\035\024 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 6.971 0 Td (\027\036\024\002)Tj 0 Tw (-)Tj 0.161 Tw -19.774 -1.218 Td (\b\024\007\017\n\024\f\021\017 \024\021\024\005\021\017 \024\021 \007\024\ \f\035\024\r\027\024\020\024 \023\036\030\036\r\024\007\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.452 Tw T* (\r\027\036\f\021\017 \027\036\022\024\021\024\030\t\036 \007\024\023\024\ \035\027\036\027\017\016/\026\022\006\036\027\021\t, \007\035\016 \031\f\ \017)Tj 0 Tw (-)Tj 0.201 Tw T* [(\035\036\027\017\016 )0.5(\r\026\032\027\024\f\021\017 \017\027\235\024\030\n\026\006\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\017\r\035\036\004\036\027\017\016 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\027\036\005 )Tj 0.182 Tw T* (\r\027\017\n\026\027\017\016 \023\026\006\017\036\027\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \f\035\031\004\026\036 \n\t \002\t\035\017 \r\t)Tj 0 Tw (-)Tj 0.104 Tw T* (\027\031\032\007\036\027\t \024\021\024\005\021\017 \024\021 \007\024\f\035\ \024\r\027\024\020\024 \023\036\030\036\r\024\007\026 \023\030\036\007\035\ \024\032\036)Tj 0 Tw (-)Tj 0.159 Tw T* (\027\017\005, \031\022\026\t\r\026\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\034 \r\024\027\017\022\027\024\r\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.153 Tw T* (\035\017\004\017\016 \f\017\n\023\021\024\n\024\r, \021\026\022 \022\026\ \022 \r)Tj /Span<>> BDC ( )Tj EMC (\022\031\035\034\021\031\030\036 \027\026\001\036\005 \f\021\030\026\027\ \t )Tj 0.096 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\017\b\024\007\036 \030\036\007\022\024 \017\f\023\024\035\034\031\ \036\021\f\016 \f\035\024\r\024 \253\026\027\031\f\273, \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\013\036 )Tj -0.027 Tw T* (\007\035\016 \031\022\026\026\027\017\016 \035\024\022\026\035\017\026\ \006\017\017, \027\026\023\030\017\n\036\030, \002\024\035\017, \023\026\ \006\017\036\027\021\t )Tj -0.021 Tw T* (\017\f\023\024\035\034\031\033\021 \024\023\030\036\007\036\035\036\027\ \017\036 \253\024\002\035\026\f\021\034 \026\007\027\036\020\024 \023\030\ \024\b\024\007\026\273. )Tj 0.098 Tw T* (\212\030\031\020\017\n \023\030\017\n\036\030\024\n \016\r\035\016\036\021\ \f\016 \026\n\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\024\005 )Tj 0.165 Tw T* [(\r\036\030\f\017\017 \024\023\030\024\f\027\017\022\026 \020\035\026\020\ \024\035\026 )0.5(\253\n\036\001\026\021\034\273 \027\026)]TJ /Span<>> BDC ( )Tj EMC 17.338 0 Td [(\020\035\026\020\024\035 )0.5(\253\026)]TJ 0 Tw (-)Tj 0.005 Tw -17.338 -1.218 Td (\021\030\031\007\027\016\021\034\273, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \024\023\017\f\026\027\017\016 \r\035\017\016\027\ \017\016 \f\017\n\023\021\024\n\024\r )Tj 0.157 Tw T* (\020\036\n\024\030\030\024\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \032\017\027\034 \023\026\006\ \017\036\027\021\026, \021\024\004\027\036\036 )Tj 0.019 Tw T* (\024\021\030\026\032\026\036\021 \f\n\t\f\035 \021\024\020\024, \024)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \f\023\030\026\001\017\r\026\036\021\f\016. \200\024 \r\021\024\ \030\024\n )Tj 0.009 Tw T* (\f\035\031\004\026\036, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \022\024\020\027\017\021\017\r\027\ \024\020\024 \007\036\002\030\017\235\017\027\020\026 \023\026)Tj 0 Tw (-)Tj 0.144 Tw T* (\006\017\036\027\021\024\r \n\t \023\024\027\016\035\017, \004\021\024 \027\ \036\024\002\b\024\007\017\n\024 \r\t\007\036\035\036\027\017\036 \021\036\ \b )Tj 0.15 Tw T* [(\004\026\f\021\036\005 )0.5(\021\036\022\f\021\026, \022\024\021\024\030\t\036 \031\022\026\t\r\026\ \033\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\020\024\030\017\024\027\021 )0.5(\r\030\036)]TJ 0 Tw (-)Tj 0.023 Tw T* (\n\036\027\017, \026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\005 \023\026\006\017\036\027\021\031 \023\030\036\ \007\035\026\020\026\036\021\f\016 \007\026\021\034 \024\006\036\027\022\ \031 )Tj 0.104 Tw T* [(\021\016\032\036\f\021\017 )0.6(\f\017\n\023\021\024\n\024\r )0.5(\020\036\n\024\030\030\024\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.512 0 Td [(\017\b )0.5(\r\035\017\016\027\017\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.385 0 Td (\022\026\004\036)Tj 0 Tw (-)Tj 0.019 Tw -19.897 -1.218 Td (\f\021\r\024 \032\017\027\017. \233\021\024 \032\036 \022\026\f\026\036\ \021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\026 \2123, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.121 Tw T* (\f\023\030\026\001\017\r\026\036\021\f\016 \024\002 \031\007\024\r\035\036\ \021\r\024\030\036\027\027\024\f\021\017 \b\017\030\031\030\020\017\004\036\ \f\022\017\n )Tj 0.095 Tw T* (\035\036\004\036\027\017\036\n, \023\030\024\r\036\007\036\027\027\t\n \r\ )Tj /Span<>> BDC ( )Tj EMC (\002\035\017\032\026\005\001\031\033 \022)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\036 \017\027\021\036\030)Tj 0 Tw (-)Tj 0.189 Tw T* (\r\034\033\017\030\024\r\026\027\017\016 \027\036\007\036\035\033. \200\026\ \032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \r\027\036\f\036\ \027)Tj 0 Tw (-)Tj 0.183 Tw T* (\027\t\036 \027\026\n\017 \017\n\036\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\022\f\021 \024\023\030\024\f\027\017\022\026, \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj 0.009 Tw T* (\f\022\026\026\027\024 \030\026\027\036\036, \027\036 \023\030\017\r\036\ \035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\033 \022\024\027\f\021\030\031\022\006\017\017\ )Tj 0.103 Tw T* (\007\024\n\036\027\024\r \017, \004\021\024 \f\026\n\024\036 \020\035\026\ \r\027\024\036, \026\035\024\032\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017)Tj 0 Tw (-)Tj T* (\027\026\035\034\027\024\n \024\023\030\024\f\027\017\022\036 \f\n\t\f\035\ \024\r.)Tj 0.088 Tw T* (\200 \b\024\007\036 \023\030\024\r\036\007\036\027\017\016 \022\024\020\027\ \017\021\017\r\027\t\b \017\027\021\036\030\r\034\033 \002\t\035\017 \r\t\ )Tj 0 Tw (-)Tj 0.069 Tw T* (\016\r\035\036\027\t \024\023\030\036\007\036\035\036\027\027\t\036 \024\ \020\030\026\027\017\004\036\027\017\016, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\036 \031\022\026)Tj 0 Tw (-)Tj 0.206 Tw T* (\026\035\017 \030\036\f\023\024\027\007\036\027\021\t. \200\024-\023\036\ \030\r\t\b, \021\024, \004\021\024 \024\023\030\024\f\027\017\022 \027\036\ )Tj 0.216 Tw T* (\031\004\017\021\t\r\026\036\021 \017\n\036\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036)Tj 0 Tw (-)Tj 0.079 Tw T* (\n\024\030\030\024\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\024\f\030\024\004\027\024\005 \023\036\030\f\023\036\022\ \021\017\r\036, \024\020\030\026\027\017\004\017\r\026\036\021 )Tj -0.039 Tw T* [(\036\020\024 )0.5(\023\030\017\n\036\027\036\027\017\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.468 0 Td [(\021\030\026\022\021\024\r\022\031 )0.5(\023\024\035\031\004\036\027\027\t\b )0.6(\030\036\031\035\034\021\026\021\024\r. )]TJ 0.158 Tw 15.776 64.543 Td (\200\024-\r\021\024\030\t\b, \023\030\017\n\036\027\017\n\024\f\021\034 \ \024\023\030\024\f\027\017\022\026 \f\030\036\007\017 \023\026\006\017\036\ \027)Tj 0 Tw (-)Tj 0.119 Tw T* (\021\024\r, \023\030\024\001\036\007\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\026\r\027\036\n \r\030\036\n\036\027\017 \b\017\030\031\030\ \020\017\004\036\f\022\024\036 )Tj 0.088 Tw T* (\035\036\004\036\027\017\036, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \031\004\026\f\021\027\017\022\024\r \022\024\020\ \027\017\021\017\r\027\t\b \017\027\021\036\030)Tj 0 Tw (-)Tj 0.245 Tw T* (\r\034\033, \027\036 \031\004\017\021\t\r\026\036\021 \017\b \024\023\t\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \n\036\007\017\022\026)Tj 0 Tw (-)Tj 0.152 Tw T* (\n\036\027\021\024\027\024\005 \021\036\030\026\023\017\017, \004\021\024\ \n\024\032\036\021 \f\024\007\026\r\026\021\034 \024\013\031\013\036\027\ \017\036 )Tj 0.361 Tw T* (\027\036\007\024\f\022\026\026\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\024\021\t \220\021\024\020\024 \017\027\f\021\030\ \031\n\036\027\021\026. )Tj 0.324 Tw 0 -1.218 TD (\222\023\036\006\017\235\017\022\026 \024\023\030\024\f\027\017\022\026 \ \002\036 \027\036\024\002\b\024\007\017\n\t\b \026\022\006\036\027\021\024\ \r, )Tj 0.151 Tw 0 -1.218 TD (\f\007\036\035\026\027\027\t\b \023\036\030\036\007 \027\026\004\026\035\ \024\n \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\n, \n\024\032\036\021 \023\024)Tj 0 Tw (-)Tj 0.25 Tw T* (\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\030\017\016\021\017\036 \r\024\023\030\024\f\024\r \017, \f\ \024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj 0.021 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\t. \203\026\023\030\017\n\036\030, \024\021\n\036\004\ \036\027\026 \r\036\030\024\016\021\027\024\f\021\034 \021\024\020\024, \ \004\021\024 )Tj 0.354 Tw T* [(\030\036\f\023\024\027\007\036\027\021\t \002\031\007\031\021 )0.5(\007\026\r\026\021\034 \253\031\f\030\036\007\027\036\027\027\t\036\273 \ )0.5(\024\021\r\036\021\t, )]TJ -0.043 Tw T* [(\031\004\017\021\t\r\026\033\013\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.556 0 Td [(\006\036\035\024\n \017\b )0.5(\024\023\t\021 )0.5(\027\026\035\017\004\017\016 )0.5(\020\036\n\024\030\030\024\016, \026)]TJ /Span<>> BDC ( )Tj EMC 14.576 0 Td (\027\036 )Tj 0.349 Tw -21.132 -1.218 Td (\022\024\027\022\030\036\021\027\t\005 \024\023\t\021, \024\021\030\026\032\ \026\033\013\017\005 \r\035\017\016\027\017\036 \020\036\n\024\030\030\024\ \016 )Tj 0.101 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\032\017\027\034 \023\026\006\017\036\027\021\026 \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\001\036\007\001\031\033 \027\036\007\036\035\033 \(\002\035\ \017\032\026\005)Tj 0 Tw (-)Tj 0.11 Tw 0 -1.218 TD (\001\031\033 \022)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\036 \026\023\024\035\027\036\027\017\016 \024\023\030\024\f\ \027\017\022\026\). \215\024\220\021\024\n\031 \021\030\036\002\031)Tj 0 Tw (-)Tj 0.029 Tw T* (\036\021\f\016 \022\026\022 \n\024\032\027\024 \002\024\035\036\036 \004\ \036\021\022\024 \031\022\026\t\r\026\021\034, \004\021\024 \030\036\004\ \034 \017\007\036\021 )Tj 0 Tw T* (\024\002 \017\027\021\036\030\r\026\035\036 \r\030\036\n\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\031, \002\035\017\032\026\005\001\031\033, \027\036\007\036\ \035\033.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.322 Tw 10 0 0 10 303.3071 469.0918 Tm [(\210\023\030\024\f\027\017\022 PROM-HIS)17(S, \023\030\036\007\027\026\027\026\004\036\027\027\t\005 \007\035\016 \ \024\006\036\027)]TJ 0 Tw (-)Tj 0.23 Tw T* [(\022\017 )0.5(\r\035\017\016\027\017\016 )0.6(\020\036\n\024\030\030\024\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 11.127 0 Td [(\023\024\r\f\036\007\027\036\r\027\031\033 )0.6(\026\022\021\017\r\027\024\f\021\034 )]TJ -0.011 Tw -11.127 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\034 \b\017\030\ \031\030\020\017\004\036\f\022\017\n \035\036\004\036\027\017\036\n \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj -0.041 Tw T* (\r\024\007\031 \007\026\027\027\024\020\024 \026\002\024\035\036\r\026\027\ \017\016, \023\030\024\001\036\035 \016\t\022\024\r\031\033 \r\026\035\017\ \007\026)Tj 0 Tw (-)Tj 0.033 Tw T* (\006\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \016\t\022. \221\026\022\017\n \024\002\030\026\ \024\n, \036\020\024 \235\017\027\026\035\034\027\026\016 )Tj 0.399 Tw T* [(\r\036\030\f\017\016, PROM-HIS)17(S_R)12(U, \n\024\032\036\021 \002\t\021\034 \017\f\023\024\035\034\024\r\026\027\ \026 )]TJ 0.094 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \022\026\022 PRO \017\027\f\021\030\ \031\n\036\027\021, \017\f\023\024\035\034\031\033\013\017\005\f\016 )Tj 0.001 Tw T* (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\031\004\027\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\024\005 \007\036\016\021\036\035\034\027\ \024\f\021\017 \030\024\f)Tj 0 Tw (-)Tj 0.16 Tw T* (\f\017\005\f\022\017\b \r\030\026\004\036\005, \026\027\017\n\026\033\013\ \017\b\f\016 \035\036\004\036\027\017\036\n \030\031\f\f\022\024\020\024\ )Tj 0 Tw (-)Tj T* (\r\024\030\016\013\017\b \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 322.9558 Tm [(\f\033\031\r\037)21(\222\034\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 303.3071 298.5998 Tm (\013\t\007\003\004\206\n\005\007\n 1)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.185 Tw 9 0 0 9 303.3071 279.2959 Tm [(\020\004\206\f\t\204\004 )0.6(1.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(\225\020\032\020\n\023\027\032\022\024\023\022\n\022 )0.6(\033\020\006\022\027\025\023\031\021, )0.6(\033\032\022\025\t\021\213\022\200 )0.6(\r\007\020)]TJ 0 Tw (-)Tj 0 -1.2 TD (\024\023\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\n\031\b\025\022\023\022\021\025\013\200 \022\025\023\027\032\021\017\005\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.035 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.008 Tw 3.332 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s w)6(h)-2.4(o p)-6.3(a)-4.2(r)-41.8(t)-29.1(i)-1.8(c)-30.1(i)1.3(p)-6.3(a)-9.2(t)-1.6(e)-12.9(d i)4(n c)2.8(o)-8.6(g)-2.4(n)1.7(i)]TJ 0 Tw 20.939 0 Td (-)Tj 0.001 Tc -0.001 Tw -24.271 -1.2 Td [(t)-28.1(i)-1.9(v)3.3(e)1.1( i)4.9(nt)-0.6(e)-5(r)-41.9(v)-31.4(ie)-7(w)-2.4(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 242.3939 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 230.4377 cm 0 0 m 0 11.706 l S Q q 1 0 0 1 450.9586 242.3939 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 230.4377 cm 0 0 m 0 11.706 l S Q q 1 0 0 1 524.6594 230.4377 cm 0 0 m 0 11.706 l S Q q 1 0 0 1 303.3071 230.1877 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 199.0394 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 450.9586 230.1877 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 199.0394 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 524.6594 199.0394 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 303.3071 198.7894 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 186.8411 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 450.9586 198.7894 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 186.8411 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 524.6594 186.8411 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 303.3071 186.5911 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 174.6428 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 450.9586 186.5911 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 174.6428 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 524.6594 174.6428 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 303.3071 174.3928 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 143.2445 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 450.9586 174.3928 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 143.2445 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 524.6594 143.2445 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 303.3071 142.9945 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 131.0462 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 450.9586 142.9945 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 131.0462 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 524.6594 131.0462 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 303.3071 130.7962 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 80.448 cm 0 0 m 0 50.098 l S Q q 1 0 0 1 450.9586 130.7962 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 80.448 cm 0 0 m 0 50.098 l S Q q 1 0 0 1 524.6594 80.448 cm 0 0 m 0 50.098 l S Q q 1 0 0 1 303.3071 80.198 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 450.9586 80.198 cm 0 0 m 73.951 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 349.6823 233.3908 Tm (\225\004\006\004\220\003\r\006\t\217\003\t\220\004)Tj 13.134 0 Td (\200\004\204\t\r\b\003\013 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10\))Tj /T1_0 1 Tf -18.545 -1.525 Td (\215\024\035)Tj 1.063 -1.2 Td (\204\031\032. \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj T* (\240\036\027. \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 19.998 1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj T* (5)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj -21.061 -1.525 Td (\200\024\030\026\f\021, \035\036\021 \(\f\030\036\007\027\036\036, \007\ \017\026\023\026\024\027\))Tj 20.413 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(31\22671\))Tj -20.413 -1.525 Td (\203\024\f\017\021\036\035\034 \030\031\f\f\022\024\020\024 \016\t\022\026\ \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 20.561 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj -20.561 -1.525 Td (\210\002\030\026\024\r\026\027\017\036 \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 1.063 -1.2 Td (\222\030\036\007\027\036\036-\f\023\036\006\017\026\035\034\027\024\036 \ )Tj T* (\200\t\f\001\036\036)Tj 19.998 1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj T* (7)Tj /Span<>> BDC ( )Tj EMC (\(70%\))Tj -21.061 -1.525 Td (\222\021\026\032 \020\036\n\024\030\030\024\016, \035\036\021 \(\f\030\036\ \007\027\036\036, \007\017\026\023\026\024\027\))Tj 20.663 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(3\22650\))Tj -20.663 -1.525 Td (\222\021\026\007\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (Goliger \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 1.063 -1.2 Td (I)Tj T* (II)Tj T* (III)Tj T* (IV)Tj 19.998 3.6 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 20.8528 56.0378 Tm (140)Tj ET endstream endobj 702 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \213\212\217\r)10(\025\b\025\221 \n\022\r\005\025\016\016-\r\002\020\200)21(\026)-19.9(\002\005\t\025\221 \b\017\020\n\202\017\n\n )]TJ 0 -1 TD [(\025\224\005\025\016\t\n\r\017 PRO)20(M-HIS)21(S \202)-21(\020\213 \224\017\n\004\t\026)11(\025\b \016\022\013)10(\004\024\025\005\005\025\004\024)]TJ 39.217 1 Td [(Results of\022linguistic and cr)20(oss-cultur)21(al v)10(alidation of\022th)11(e )]TJ 21.255 0 Td ( )Tj -25.84 -1 Td [(PRO)20(M-HIS)21(S questionnair)31.1(e for patients with h)11(emorrh)11(oidal disease)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.214 Tw 10 0 0 10 42.5197 724.8299 Tm (\253\024\013\031\013\036\027\017\017\273, \022\024\021\024\030\024\036 \027\ \036 \024\002\016\026\021\036\035\034\027\024 \007\024\035\032\027\024 \ \023\024\007)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\r\036\030\032\007\026\021\034\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\f\021\024\016\021\036\035\034\027\024\n \024\002\f\035\036\007\ \024\r\026\027\017\017.)Tj -0.07 Tw T* (\200 \006\036\035\024\n, \r\024\023\030\024\f \2122 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \017\n\036\033\021\f\016 \035\017 \026\021\030\031\007\027\036\ \027\017\016, \024\002)Tj 0 Tw (-)Tj 0.072 Tw T* (\031\f\035\024\r\035\036\027\027\t\036 \027\026\035\017\004\017\036\n \023\ \036\030\036\004\017\f\035\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\2121 \f\017\n\023\021\024)Tj 0 Tw (-)Tj -0.001 Tw T* (\n\024\r \020\036\n\024\030\030\024\016, \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\024\005 \032\017\027\017 \024\023\030\ \026\001\017\r\026\036\n\t\b, )Tj -0.011 Tw T* (\002\t\035 \007\035\016 \027\017\b \023\024\027\016\021\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \r\t\t\r\026\r\001\036\n \026\021\030\031\007\027\036\027\017\ \005 )Tj -0.049 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.704 0 Td [(\024\021\r\036\021\036. )0.5(\210\007\027\026\022\024 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.021 0 Td [(\024\002\f\031\032\007\036\027\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.859 0 Td [(\023\026\006\017\036\027\021\026\n\017 )0.6(\r\t)]TJ 0 Tw (-)Tj -0.038 Tw -15.585 -1.218 Td [(\016\f\027\017\035\024\f\034, )0.6(\004\021\024 )0.6(\n\027\024\020\017\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.985 0 Td [(\027\017\b )0.6(\(6/10\) )0.6(\023\030\024\023\031\f\021\017\035\017 )0.6(\021\024, )0.6(\004\021\024 )]TJ 0.039 Tw -9.985 -1.218 Td (\r\024\023\030\024\f \007\026\027\027\024\020\024 \007\024\n\036\027\026\ \022\026\f\026\036\021\f\016 \021\024\035\034\022\024 \002\035\017\032\026\ \005\001\036\020\024 )Tj 0.157 Tw 0 -1.218 TD [(1-\027\036\007\036\035\034\027\024\020\024 )0.6(\024\023\t\021\026. )0.5(\221\024 )0.5(\036\f\021\034 )0.5(\030\036\f\023\024\027\007\036\027\021\t )0.6(\024\021\r\036\004\026\035\017 )]TJ 0.149 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\024\023\030\024\f \2122, \r\f\023\024\n\017\027\026\016 )0.5(\r\035\017\016\027\017\036 \f\017\n\023\021\024\n\024\r \027\026)]TJ /Span<>> BDC ( )Tj EMC (\017\b )Tj -0.034 Tw T* (\032\017\027\036\007\036\016\021\036\035\034\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\036 \023\036\030\017\024\007\t \021\036\004\036\027\017\016\ \002\024\035\036)Tj 0 Tw (-)Tj -0.051 Tw 0 -1.218 TD [(\027\017: )0.5(\253\022\024\020\007\026 )0.6(\002\t\035\024 )0.5(\024\002\024\f\021\030\036\027\017\036\273, )0.5(\253\r\027\036 )0.6(\024\002\024\f\021\030\036\027\017\016\273 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.637 0 Td (\021.\023. )Tj 0.029 Tw -20.637 -1.218 Td (\025\026\022 \030\036\031\035\034\021\026\021, \007\035\016 \002\024\035\ \036\036 \004\036\021\022\024\020\024 \023\024\027\017\n\026\027\017\016\ \023\026\006\017\036\027)Tj 0 Tw (-)Tj -0.026 Tw 0 -1.218 TD [(\021\024\n \020\024\030\017\024\027\021\026 )0.5(\r\030\036\n\036\027\017, )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n\031 )0.5(\024\021\027\024\f\017\021\f\016 \r\024\023\030\024\f, )]TJ 0.051 Tw T* [(\030\026\002\024\004\036\005 \020\030\031\023\023\024\005 \002\t\035\024\ \030\036\001\036\027\024 \r\t\007\036\035\017\021\034 )0.5(\021\036\022\f\021 \f)]TJ /Span<>> BDC ( )Tj EMC (\031\022\026)Tj 0 Tw (-)Tj -0.035 Tw T* [(\026\027\017\036\n \024\007\027\024\027\036\007\036\035\034\027\024\020\ \024 )0.5(\017\027\021\036\030\r\026\035\026 \032\017\030\027\t\n \001\030\017\235\ \021\024\n, )]TJ 0.202 Tw T* (\004\021\024 \f\007\036\035\026\036\021 \007\026\027\027\031\033 \017\027\ \235\024\030\n\026\006\017\033 \002\024\035\036\036 \024\004\036\r\017\007\ \027\024\005 )Tj 0 Tw T* (\007\035\016 \030\036\f\023\024\027\007\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\002\031\007\031\013\036\n.)Tj -0.002 Tc 0.091 Tw T* (\200\024\023\030\024\f \2123 \024\002 \031\007\024\r\035\036\021\r\024\030\ \036\027\027\024\f\021\017 \023\026\006\017\036\027\021\026 \b\017\030\031\ \030\020\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.112 Tw T* (\004\036\f\022\017\n \035\036\004\036\027\017\036\n, \023\030\024\r\036\007\ \036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.235 Tw T* (\f\035\036\007\027\033\033 \027\036\007\036\035\033, \002\t\035, \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \023\024\027\016\021\036\027 \007\035\016 \024\021\r\ \036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.187 Tw T* (\004\026\033\013\017\b. \210\007\027\026\022\024, \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \021\024\020\024, \004\021\024 \007\036\r\016\021\034 \017\ )Tj /Span<>> BDC ( )Tj EMC [(\007\036\f\016\021\017)-2( )]TJ 0.077 Tw T* (\024\023\030\024\001\036\027\027\t\b \023\026\006\017\036\027\021\024\r \ \027\036 \023\030\024\b\024\007\017\035\017 \b\017\030\031\030\020\017\004\ \036\f\022\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.239 Tw T* (\020\024 \035\036\004\036\027\017\016, \r\024\023\030\024\f \r\t\t\r\026\ \035 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \024\013\031\013\036\027\017\036 \023\030\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.257 Tw T* (\027\036\002\030\036\032\036\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\027\024\005 \f\r\016\017 \024)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\027\024\n \017\035\017)-2( )]TJ 0.028 Tw T* (\023\030\024\r\024\007\017\n\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \n\036\007\017\022\026\n\036\027\021\024\027\024\n \035\036\004\ \036\027\017\017. \200)Tj /Span<>> BDC ( )Tj EMC [(\b\024\007\036)-2( )]TJ 0.076 Tw T* [(\024\002\f\031\032\007\036\027\017\016 )0.5(\024\021\r\036\021\024\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.039 0 Td [(\r\024\023\030\024\f )0.5(\2123 )0.6(\002\t\035\024 )0.5(\021\026\022\032\036 )0.5(\r\t\016\f)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.044 Tw -10.039 -1.218 Td [(\027\036\027\024, )0.5(\004\021\024 \004\026\f\021\024 )0.5(\017\f\023\024\035\034\031\033\013\017\036\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\017 \020\036\n\024\030\030\024\016)-2( )]TJ 0.039 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\030\024\f\f\017\005\f\022\017\b \023\026\006\017\036\027\021\024\r \n\026\ \035\024\017\027\r\026\017\r\027\t\036 \b\017\030\031\030\020\017\004\036\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.008 Tw T* (\f\022\017\036 \024\023\036\030\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\026\036\030\026 \027\036 \ \002\t\035\017 \031\023\024\n\016)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.081 Tw T* (\027\031\021\t \r\024\r\f\036, \004\021\024 \027\036 \023\024\r\024\035\ \017\035\024, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\027\036\027\017\033 \027\036\022\024\021\024\030\t\b)-2( )]TJ 0.178 Tw T* (\030\036\f\023\024\027\007\036\027\021\024\r \(3/10\), \023\024\035\027\024\ \006\036\027\027\024 \024\006\036\027\017\021\034 \017\b \031\007\024\r)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.24 Tw T* (\035\036\021\r\024\030\036\027\027\024\f\021\034 \b\017\030\031\030\020\017\ \004\036\f\022\017\n \035\036\004\036\027\017\036\n, \024)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n)-2( )]TJ 0.248 Tw T* (\f\023\030\026\001\017\r\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\036. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\220\021\017\n, \023\024\f\035\036)-2( )]TJ 0.164 Tw T* (\024\002\f\031\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\004\036\005 \020\030\031\023\023\036, \002\t\035\024 \023\ \030\017\027\016\021\024 \030\036\001\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.17 Tw T* [(\027\017\036 \007\024\023\024\035\027\017\021\034 \017\n\036\033\013\017\ \005\f\016 \023\036\030\036\004\036\027\034 \b\017\030\031\030\020\017\004\ \036\f\022\017\b)-2( )]TJ 0.047 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r \031\023\024\n\017\027\026\027\017\ \036\n \024)Tj /Span<>> BDC ( )Tj EMC (\035\026\036\030\027\024\n \031\007\026\035\036\027\017\017 \031)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.003 Tw T* (\035\024\r, \024)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n \023\026\006\017\036\027\021\t \024\004\036\027\ \034 \b\024\030\024\001\024 \024\f\r\036\007\024\n\035\036\027\t.)-2( )]TJ -0.014 Tw T* (\200\f\036 \004\035\036\027\t \030\026\002\024\004\036\005 \020\030\031\023\ \023\t \023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\022\035\033\004\036\027\017\033, \004\021\024)-2( )]TJ 0.027 Tw T* [(\007\026\027\027\024\036 \007\024\023\024\035\027\036\027\017\036 )0.5(\027\036 \n\036\027\016\036\021 \f\036\n\026\027\021\017\022\031 \r\024\023\ \030\024\f\026 \2123,)-2( )]TJ -0.006 Tw T* (\027\024 \023\024\r\024\035\017\021 \023\026\006\017\036\027\021\031 \024\ \006\036\027\017\021\034 \f\r\024\036 \024\021\027\024\001\036\027\017\036\ \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.095 Tw T* (\r\036\007\036\027\027\024\n\031 \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\n\031 \035\ \036\004\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\036\021\024\n)-2( )]TJ 0.43 Tw T* [(\027\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\t\b )0.5(\r\017\007\024\r )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\b)-2( )]TJ 0.038 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \020\036\n\024\030\030\024\016 \r)Tj /Span<>> BDC ( )Tj EMC (\217\205. \217\016\007 \022\024\n\n\036\027)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.038 Tw T* (\021\026\030\017\036\r \(2/10\) \002\t\035 \007\026\027 \030\036\f\023\024\ \027\007\036\027\021\026\n\017 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \027\024\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.039 Tw T* (\035\024\020\017\016, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \022\024\021\024\030\024\005 \023\030\024\r\024\007\ \017\035\024\f\034 \b\017\030\031\030\020\017\004\036\f\022\024\036)-2( )]TJ 0.212 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\024, )0.5(\021.\036. )0.6(\020\036\n\024\030\030\024\016, )0.5(\f\021\024\017\021 )0.6(\r\027\031\021\030\017 )0.5(\f\022\024\002\024\022,)-2( )]TJ 0.091 Tw T* (\f\024\007\036\030\032\026\013\017\b \031\021\024\004\027\036\027\017\036\ \030\026\035\017\004\027\t\b \r\017\007\024\r \b\017\030\031\030\020\017\ \004\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.185 Tw T* (\f\022\017\b \r\n\036\001\026\021\036\035\034\f\021\r. \233\021\024 \023\ \030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\n\036\001\026\021\036\035\034\f\021\r\031)-2( )]TJ 0.012 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.714 0 Td [(\024\021\027\024\001\036\027\017\017 )0.5(\021\024\020\024, )0.5(\r\f\036 )0.5(\035\017 )0.5(\036\013\036 )0.5(\030\036\004\034 )0.5(\017\007\036\021 )0.5(\024\002 )0.5(\031\022\026\026\027\027\024\005)-2( )]TJ 0.11 Tw -0.714 -1.218 Td (\002\024\035\036\027\017 \017\035\017 \032\036 \017\b \f\023\030\026\001\ \017\r\026\033\021 \024\002 \031\007\024\r\035\036\021\r\024\030\036\027\ \027\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.024 Tw T* (\f\021\017 \035\033\002\t\n\017 \007\030\031\020\017\n\017 \b\017\030\031\ \030\020\017\004\036\f\022\017\n\017 \r\n\036\001\026\021\036\035\034\f\021\ \r\026)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.139 Tw T* (\n\017, \022\024\021\024\030\t\n \024\027\017 \n\024\020\035\017 \023\024\ \007\r\036\030\020\027\031\021\034\f\016 \026)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\027\036\036)-2( )]TJ 0.094 Tw 23.244 64.543 Td [(\r\030\036\n\016. \221\026\022, \027\026\023\030\017\n\036\030, \027\036\ \f\022\024\035\034\022\024 \023\026\006\017\036\027\021\024\r \f\022\026\ \026\035\017,)-2( )]TJ 0.03 Tw T* [(\004\021\024 )0.5(\f\027\026\004\026\035\026 \002\t\035\017 \f\024\n\027\036\027\017\016, \ \004\021\024 )0.5(\017\b \f\023\030\026\001\017\r\026\033\021 \024)]TJ /Span<>> BDC ( )Tj EMC 20.82 0 Td (\035\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.017 Tw -20.82 -1.218 Td (\004\036\027\017\017 \020\036\n\024\030\030\024\016, \017, \004\021\024 \ \036\f\035\017 \002\t \r)Tj /Span<>> BDC ( )Tj EMC [(\r\024\023\030\024\f\036 \031\023\024\n\017\027\026\027\017\036)-2( )]TJ 0.053 Tw T* (\020\036\n\024\030\030\024\016 \002\t\035\024 \002\t \r\t\027\036\f\036\027\ \024 \026)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\002\022\017, \021\024 \220\021\024 \024\002\035\036\020)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.124 Tw T* [(\004\026\035\024 )0.5(\002\t )0.5(\002\024\035\036\036 )0.5(\035\036\020\022\024\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.439 0 Td [(\002\t\f\021\030\024\036 )0.5(\r\024\f\023\030\017\016\021\017\036 )0.5(\r\024\023\030\024)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.275 Tw -10.439 -1.218 Td (\f\026. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n \007\026\027\027\t\b \022\024\n\n\ \036\027\021\026\030\017\036\r \030\026\002\024\004\036\005)-2( )]TJ -0.022 Tw 0 -1.218 TD (\020\030\031\023\023\024\005 \030\036\001\036\027\024 \002\t\035\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\235\017\027\026\035\034\027\024\005 \r\036\030\f\017\017 \024\023\030\024\ \f\027\017\022\026)-2( )]TJ 0.238 Tw 0 -1.218 TD [(\031\023\024\n\017\027\026\027\017\036 \f\026\n\024\005 \027\024\024\035\ \024\020\017\017, \020\036\n\024\030\030\024\016, \023\036\030\036\027\036\ \f\021\017)-2( )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\002\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \021\036\022\f\021.)Tj 0 Tc 0.227 Tw T* (\200 \006\036\035\024\n, \023\024\f\035\036 \023\030\024\r\036\007\036\027\ \017\016 \022\024\020\027\017\021\017\r\027\t\b \017\027\021\036\030\r\034\ \033 )Tj 0.302 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \017\b \030\036\031\035\034\021\026\021\026\n \f\007\036\035\026\ \027 \r\t\r\024\007, \004\021\024 \024\023\030\024\f\027\017\022 )Tj 0.119 Tw T* (\r\024\f\023\030\017\027\017\n\026\036\021\f\016 \031\004\026\f\021\027\017\ \022\026\n\017 \023\024\017\021\017\r\027\024: \036\020\024 \f\024\007\036\ \030)Tj 0 Tw (-)Tj 0.197 Tw 0 -1.218 TD [(\032\017\n\024\036 \f\024\024\021\r\036\021\f\021\r\031\036\021 )0.5(\023\030\036\007\f\021\026\r\035\036\027\017\016\n \017)]TJ /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\027\017\016\n )Tj 0.161 Tw 0 -1.218 TD [(\023\026\006\017\036\027\021\024\r )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\026\n\024\n \026\002\024\035\036\r\026\027\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\036\020\024 )0.5(\r\024\007\036\005\f\021\r\017\017 )]TJ 0.101 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\024\r\f\036\007\027\036\r\027\031\033 \032\017\027\034. \217\ \036\f\023\024\027\007\036\027\021\026\n\017 \024\021\n\036\004\036\027 \ )Tj 0.053 Tw T* (\b\024\030\024\001\024 \r\024\f\023\030\017\027\017\n\026\036\n\t\005, \023\ \030\026\r\017\035\034\027\t\005 \030\031\f\f\022\017\005 \016\t\022, )Tj 0.057 Tw T* [(\022\024\021\024\030\t\n \027\026\023\017\f\026\027 )0.5(\024\023\030\024\f\027\017\022, )0.5(\031\022\026\026\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\b\024\030\024\001\031\033 )0.5(\r\017)]TJ 0 Tw (-)Tj -0.027 Tw T* (\031\026\035\017\026\006\017\033 \007\024\n\036\027\024\r, \r\t\f\024\022\ \024 \024\006\036\027\036\027\026 \022\030\026\021\022\024\f\021\034 \235\ \024\030)Tj 0 Tw (-)Tj 0.021 Tw T* (\n\031\035\017\030\024\r\024\022, \n\017\027\017\n\031\n \r\030\036\n\036\ \027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\017\035\017\005, \022\024\021\024\030\t\036 \021\030\036)Tj 0 Tw (-)Tj -0.038 Tw T* (\002\031\033\021\f\016 \007\035\016 \036\020\024 \026\023\024\035\027\036\ \027\017\016. \221\026\022\032\036, \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\026\n \024\023\030\024\f\024\r )Tj 0.033 Tw T* (\002\t\035\024 \f\007\036\035\026\027\024 \026\022\035\033\004\036\027\017\ \036, \004\021\024 \017\f\023\024\035\034\031\036\n\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (PROM )Tj 0.238 Tw T* [(HIS)17(S_R)12(US )0.5(10-\002\026\035\035\034\027\t\036 )0.6(\004\017\f\035\024\r\t\036 )0.6(\001\022\026\035\t )0.5(\024\006\036\027\022\017 )0.6(\024\021 )]TJ 0.214 Tw T* (0 \007\024)Tj /Span<>> BDC ( )Tj EMC (10, \020\007\036 0 \024\002\024\027\026\004\026\035 \253\f\024\r\f\036\n\ \027\036 \026\021\030\031\007\027\036\027\024\273, )Tj -0.029 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (10)Tj /Span<>> BDC ( )Tj EMC [(\227 \253\024\004\036\027\034 \026\021\030\031\007\027\036\027\024\273 \ )0.5(\002\t\035\017 \023\026\006\017\036\027\021\026\n \023\024\027\016\021\027\ \t, )]TJ 0.168 Tw T* (\023\024\r\024\035\016\035\017 \035\036\020\022\024 \f\007\036\035\026\021\ \034 \024\021\n\036\021\022\031, \f\024\024\021\r\036\021\f\021\r\031\033\ \013\031\033 )Tj 0.01 Tw T* (\017\b \024\023\t\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\027\031\032\027\024\n\031 \r\026\030\017\026\027\021\031 \024\021\r\036\ \021\026. \221\026\022\017\n \024\002\030\026\024\n, )Tj 0.153 Tw T* (\030\026\002\024\004\026\016 \020\030\031\023\023\026 \f\007\036\035\026\ \035\026 \r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \024\023\030\024\f\027\017\022 )Tj 0.127 Tw T* [(PROM-HIS)17.1(S_R)11.9(US \024\002\035\026\007\026\036\021 \007\024\f\021\026\021\024\004\027\024\ \005 \022\026\022 \r\027\036\001\027\036\005, )]TJ 0.074 Tw T* (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\036\030\032\026\021\036\035\034\027\024\005 \r\026\035\017\007\ \027\024\f\021\034\033, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.318 Tw T* (\024\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\020\024\r\024\030\016\013\036\005 \023\024\023\031\035\ \016\006\017\017 \023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n, \023\030\024\032\017\r\026\033\013\017\ \b \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\030\017\021\024\030\017\017 \217\205.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 322.9558 Tm [(\230\031\032\027)10(\224)1(\032\032\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.166 Tw 10 0 0 10 274.9606 298.5998 Tm (\217\036\031\035\034\021\026\021\t \023\030\024\r\036\007\036\027\027\024\ \005 \027\026\n\017 \016\t\022\024\r\024\005 \r\026\035\017\007\026\006\ \017\017 )Tj 0.044 Tw T* [(\020\024\035\035\026\027\007\f\022\024\020\024 \024\023\030\024\f\027\017\ \022\026 PROM-HIS)17.1(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \016\t\022 )Tj 0.061 Tw T* (\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \b\024\ \030\024\001\031\033 \r\027\036\001\027\033\033 \r\026\035\017\007\027\024\ \f\021\034 )Tj 0.19 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\035\034 \032\036 \r\t\f\024\022\024\005 \f\021\030\031\022\021\ \031\030\027\024\005 \r\026\035\017\007\027\024\f\021\017 \036\020\024 )Tj 0.068 Tw T* [(\030\031\f\f\022\024\016\t\004\027\024\005 )0.6(\r\036\030\f\017\017. )0.5(\233\021\024 )0.5(\023\024\r\024\035\016\036\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.033 0 Td (\007\026\035\034\027\036\005\001\036\n )Tj 0.315 Tw -17.033 -1.218 Td (\017\f\023\024\035\034\024\r\026\021\034 \007\026\027\027\t\005 \024\023\ \030\024\f\027\017\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036 )Tj 0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.73 0 Td [(\022\026\004\036\f\021\r\036 )0.5(\017\027\f\021\030\031\n\036\027\021\026 )0.5(\007\035\016 )0.5(\017\031\004\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.869 0 Td [(\024\006\036\027\022\017 )0.5(\r\035\017\016)]TJ 0 Tw (-)Tj 0.012 Tw -16.599 -1.218 Td (\027\017\016 \f\017\n\023\021\024\n\024\r \020\036\n\024\030\030\024\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \032\017\027\034 \023\026)Tj 0 Tw (-)Tj 0.012 Tw T* (\006\017\036\027\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \022\026\004\036\f\021\r\024, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\006\036\027\017\021\034 \031\007\024\r\035\036\ \021\r\024\030\036\027)Tj 0 Tw (-)Tj 0.085 Tw T* (\027\024\f\021\034 \023\026\006\017\036\027\021\026 \023\030\024\r\024\007\ \017\n\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \026\002\024\035\036\r\026\027\017\016 )Tj 0.147 Tw T* (\024\023\036\030\026\021\017\r\027\t\n \035\036\004\036\027\017\036\n. \221\ \024\021 \235\026\022\021, \004\021\024 \024\023\030\024\f\027\017\022 \017\ \f)Tj 0 Tw (-)Tj 0.046 Tw T* (\b\024\007\027\024 \f\024\007\026\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\017 \023\026\006\017\036\027\021\024\r [6], \004\021\ \024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 )Tj 0.129 Tw T* (\024\004\036\030\036\007\034, \016\r\035\016\036\021\f\016 \027\036\024\021\ \255\036\n\035\036\n\t\n \031\f\035\024\r\017\036\n \007\035\016 \f\024\ )Tj 0 Tw (-)Tj 0.157 Tw T* (\007\026\027\017\016 PROM, \017)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \024\027 \r\022\035\033\004\026\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \r\024\023\030\024\f\t )Tj -0.019 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC 0.713 0 Td [(\f\017\n\023\021\024\n\026\b, )0.5(\016\r\035\016\033\013\017\b\f\016 )0.6(\024\f\027\024\r\027\t\n\017 )0.5(\f\017\n\023\021\024\n\026\n\017 )0.6(\020\036)]TJ 0 Tw (-)Tj 0.028 Tw -0.713 -1.218 Td (\n\024\030\030\024\016, \r\f\036 \220\021\024 \023\024\r\024\035\016\036\ \021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 PROM-)Tj -0.051 Tw T* [(HIS)17(S \023\024\035\031\004\026\021\034 \024\006\036\027\022\031 \017\031\004\ \026\036\n\t\b \023\026\030\026\n\036\021\030\024\r \024\021 \f\026\n\017\ \b )]TJ -0.033 Tw T* (\023\026\006\017\036\027\021\024\r, \004\021\024 \022\030\026\005\027\036\ \r\026\032\027\024 \007\035\016 \023\024\027\017\n\026\027\017\016 \021\ \024\020\024, \022\026\022 )Tj 0.096 Tw T* (\002\024\035\036\027\034 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\036 \022\024\027\022\030\036\021\027\024\020\ \024 \023\026\006\017\036\027\021\026, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.4895 56.0378 Tm (139)Tj ET endstream endobj 701 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.042 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\030\017\004\017\027\024\005 \027\036\016\f\027\024\f\021\017, \024)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\024\005 \022\024\027\022\030\036\021\027\024 \024\023\036\030\ \026\006\017\017 \036\020\024 )Tj 0.019 Tw 0 -1.218 TD [(\f\023\030\026\001\017\r\026\033\021, \030\036\001\036\027\024 \017\f\023\ \024\035\034\024\r\026\021\034 )0.5(\024\023\030\036\007\036\035\036\027\017\036 \253\b\017)]TJ 0 Tw (-)Tj T* (\030\031\030\020\017\004\036\f\022\024\036 \031\007\026\035\036\027\017\036\ \020\036\n\024\030\030\024\016\273.)Tj 0.152 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \023\024\f\035\036 \023\030\016\ \n\024\020\024 \023\036\030\036\r\024\007\026 \024\023\030\024\f\027\017\ \022\026 )Tj 0.02 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\031\032\007\036\027\017\016 \017\n\036\033\013\017\b\f\016 )Tj 0.081 Tw T* (\030\026\027\024\004\021\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\026\b, \r\t\023\024\035\027\036\027\027\t\b \007\ \r\031\n\016 \027\036\026)Tj 0 Tw (-)Tj 0.111 Tw 0 -1.218 TD [(\r\017\f\017\n\t\n\017 )0.5(\023\030\024\235\036\f\f\017\024\027\026\035\034\027\t\n\017 \023\036\030\ \036\r\024\007\004\017\022\026\n\017, )0.6(\f\021\026)]TJ 0 Tw (-)Tj 0.209 Tw 0 -1.218 TD [(\035\024 )0.5(\r\024\n\024\032\027\024 )0.6(\f\024\007\026\027\017\036 )0.5(\210\222\200 )0.6(\024\023\030\024\f\027\017\022\026 )0.5(PROM-HIS)17.1(S_)]TJ 0.05 Tw T* [(R)12(US, \022\024\021\024\030\026\016 \026\021\036\n \023\024\007\r\036\030\020\ \035\026\f\034 \024\002\030\026\021\027\024\n\031 \023\036\030\036\r\024\ \007\031 )]TJ -0.017 Tw T* [(\024\007\027\017\n, \030\026\027\036\036 )0.5(\027\036 \r\024\r\035\036\004\036\027\027\t\n )0.5(\023\036\030\036\r\024\007\004\017\022\024\n, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.114 Tw T* (\023\030\024\r\036\030\022\017 \f\024\b\030\026\027\036\027\017\016 \f\n\ \t\f\035\024\r\t\b \027\026\004\036\027\017\005 \007\024\n\036\027\024\r\ )Tj 0.302 Tw T* (\024\023\030\024\f\027\017\022\026. \215\024\035\031\004\036\027\027\026\ \016 \r\036\030\f\017\016 \024\002\030\026\021\027\024\020\024 \023\036\030\ \036\r\024)Tj 0 Tw (-)Tj 0.332 Tw 0 -1.218 TD (\007\026 \024\023\030\024\f\027\017\022\026 \023\024\007\r\036\030\020\035\ \026\f\034 \030\036\r\034\033\017\030\024\r\026\027\017\033, \004\021\024\ \002\t )Tj 0.068 Tw 0 -1.218 TD [(\031\002\036\007\017\021\034\f\016, \004\021\024 \022\024\027\006\036\023\ \021\031\026\035\034\027\024 )0.5(\023\036\030\036\r\024\007 \220\022\r\017\r\026\035\036\027\021\036\027 \ )]TJ 0.205 Tw 0 -1.218 TD [(\024\030\017\020\017\027\026\035\031. \215\024\021\030\036\002\024\r\026\ \035\026\f\034 )0.5(\r\f\021\030\036\004\026 \030\026\002\024\004\036\005 \020\030\031\023\023\ \t )]TJ 0.044 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\004\017\022\024\n \007\035\016 \024\002\f\031\ \032\007\036\027\017\016 \017\n\036\027\036\027\017\005, \r\027\036\f\036\ \027)Tj 0 Tw (-)Tj 0.091 Tw T* (\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\t\007\031\013\036\n \220\021\026\023\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\031\033 \r\036\030\f\017\033, )Tj 0.204 Tw T* (\023\024\007\r\036\030\020\001\031\033\f\016 \024\002\030\026\021\027\024\ \n\031 \023\036\030\036\r\024\007\031. \200\027\036\f\036\027\027\t\036 \ \017)Tj 0 Tw (-)Tj 0.225 Tw T* (\n\036\027\036\027\017\016 \023\030\017\027\026\027\t \r\f\036\n\017 \031\ \004\026\f\021\027\017\022\026\n\017 \024\002\f\031\032\007\036\027\017\016\ )Tj 0.509 Tw T* (\027\036\024\002\b\024\007\017\n\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \017\n\036\027\016\033\013\017\n\017 \022\024\027\006\036\023\021\ \031\026\035\034)Tj 0 Tw (-)Tj 0.204 Tw T* [(\027\024 \f\n\t\f\035 )0.5(\024\030\017\020\017\027\026\035\034\027\024\020\024 )0.5(\024\023\030\024\f\027\017\022\026 \017)]TJ /Span<>> BDC ( )Tj EMC 16.819 0 Td (\036\020\024 \007\024\n\036\027\024\r )Tj 0 Tw -16.819 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\024\f\021\017.)Tj /T1_1 1 Tf 0.186 Tw 0 -2.436 TD [(\021\006\002\217\217-\220\210\f\001\003\210\006\b\004\235 )0.6(\212\006\002\r\006\220\004 )0.6(\(\004\f\t\240\004\204\t\235\) )0.5(\006\210\217\217\220\002)]TJ /Span<>> BDC (-)Tj EMC 0 Tw 0 -1.218 TD (\235\213\013\201\b\002\005 \r\006\217\t\t)Tj /T1_0 1 Tf 0.287 Tw T* (\203\026 \220\021\024\n \220\021\026\023\036 \n\t \023\030\024\021\036\f\ \021\017\030\024\r\026\035\017 \210\222\200 \024\023\030\024\f\027\017\022\ \026 )Tj 0.002 Tw T* [(PROM-HIS)17.1(S_R)12(US \f\030\036\007\017 \023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\235\024\030)Tj 0 Tw (-)Tj -0.012 Tw T* [(\n\026\021\036 )0.5(\022\024\020\027\017\021\017\r\027\024\020\024 )0.5(\017\027\021\036\030\r\034\033. )0.6(\222)]TJ /Span<>> BDC ( )Tj EMC 13.106 0 Td [(\220\021\024\005 )0.5(\006\036\035\034\033 )0.6(\027\026\n\017 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.174 Tw -13.106 -1.218 Td (\r\035\036\022\026\035\017\f\034 \f\023\036\006\017\026\035\017\f\021\t \ \021\030\036\021\034\036\005 \f\021\024\030\024\027\t \(\026\020\036\027\ \021\f\021\r\024 )Tj 0.254 Tw T* [(TRENCH INSIGHT)25.1(S\), \f\023\036\006\017\026\035\017\017\030\031\033\013\036\036\f\016 \027\ \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\024\020\024 )Tj 0 Tw T* (\030\024\007\026 \017\027\021\036\030\r\034\033\017\030\024\r\026\027\017\ \017.)Tj 0.074 Tw T* [(\200 \022\024\020\027\017\021\017\r\027\024\036 \017\027\021\036\030\r\034\ \033\017\030\024\r\026\027\017\036 )0.5(\002\t\035\017 \023\030\017\020\035\026\001\036\027\t )]TJ 0.116 Tw T* (10 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \f\021\026\007\017\016\n\017 \b\030\024\ \027\017\004\036\f\022\024\020\024 )Tj 0.243 Tw T* (\020\036\n\024\030\030\024\016 \023\024)Tj /Span<>> BDC ( )Tj EMC [(Gol)-30.9(igher. \200\f\036 \023\026\006\017\036\027\021\t \023\030\036\007\024\f\021\ \026\r\017\035\017 )]TJ 0.135 Tw T* (\017\027\235\024\030\n\017\030\024\r\026\027\027\024\036 \f\024\020\035\026\ \f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\034\033. )Tj 0.028 Tw T* (\210\f\027\024\r\027\t\036 \b\026\030\026\022\021\036\030\017\f\021\017\022\ \017 \031\004\026\f\021\027\017\022\024\r \031\022\026\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002)Tj 0 Tw (-)Tj 0.246 Tw T* (\035\017\006\036 1 \(\215\030\017\035\024\032\036\027\017\036\). \215\026\ \006\017\036\027\021\026\n \002\t\035\024 \023\030\036\007\035\024\032\036\ )Tj 0 Tw (-)Tj 0.127 Tw T* (\027\024 \024\027\026\022\024\n\017\021\034\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\017\021\034 \210\222\200 \024\023\030\024\f\027\017\ \022\026, \023\024\f\035\036 )Tj 0.036 Tw T* (\004\036\020\024 \017\b \f\023\030\026\001\017\r\026\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\021\036 \017\027\f\021\030\031\022\006\017\005, \r\024\ \023\030\024\f\024\r )Tj 0.196 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\027\021\024\r \024\021\r\036\021\024\r, \r\022\035\033\ \004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024 \(\r\027\036\001\027\016\016 )Tj -0.023 Tw T* (\r\026\035\017\007\027\024\f\021\034\) [10]. \025\030\024\n\036 \021\024\ \020\024, \023\026\006\017\036\027\021\024\r \023\030\024\f\017\035\017 \ \r\t)Tj 0 Tw (-)Tj 0.277 Tw T* (\f\022\026\026\021\034 \n\027\036\027\017\036 \022\026\f\026\021\036\035\ \034\027\024 \030\036\035\036\r\026\027\021\027\024\f\021\017 \023\031\027\ \022\021\024\r )Tj 0.057 Tw T* (\024\023\030\024\f\027\017\022\026 \017\b \f\024\002\f\021\r\036\027\027\ \024\n\031 \024\023\t\021\031 \032\017\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\036\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024 \027\036\007\024\f\021\026\033\013\017\b \030\026\ \007\036\035\026\b \017\035\017 )Tj 0.196 Tw T* (\023\031\027\022\021\026\b, \022\024\021\024\030\t\036 \023\024\n\024\020\ \035\017 \002\t \023\024\035\027\024\006\036\027\027\024 \024\021\030\026\ \017\021\034 )Tj 0.037 Tw T* (\r\f\036 \026\f\023\036\022\021\t \027\026\035\017\004\017\016 \020\036\n\ \024\030\030\024\016 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\036 )Tj -0.028 Tw T* [(\026\002\024\035\036\r\026\027\017\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.659 0 Td [(\022\026\004\036\f\021\r\024 )0.5(\032\017\027\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.415 0 Td (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\017 )Tj 0.018 Tw -14.074 -1.218 Td (\023\030\024\r\024\007\017\n\t\n \035\036\004\036\027\017\036\n \(\f\024\ \007\036\030\032\026\021\036\035\034\027\026\016 \r\026\035\017\007\027\024\ \f\021\034\) )Tj 0.21 Tw T* ([10]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\017 \024\023\030\024\f\027\017\022\026\ \027\026\n\017 \235\017\022\f\017\030\024\r\026)Tj 0 Tw (-)Tj 0.048 Tw T* (\035\024\f\034 \r\030\036\n\016, \021\030\036\002\031\033\013\036\036\f\016\ \022\026\032\007\024\n\031 \031\004\026\f\021\027\017\022\031 \007\035\016\ \026)Tj 0 Tw (-)Tj T* (\r\036\030\001\036\027\017\016 \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\n.)Tj 0.205 Tw T* (\200 \006\036\035\024\n, \r\f\036 \031\004\026\f\021\027\017\022\017 \f\n\ \024\020\035\017 \024\021\r\036\021\017\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024)Tj 0 Tw (-)Tj 0.078 Tw T* (\f\t \024\023\030\024\f\027\017\022\026 \f\026\n\024\f\021\024\016\021\036\ \035\034\027\024, \007\035\016 \004\036\020\024 \021\030\036\002\024\r\026\ \035\024\f\034 )Tj 0.08 Tw T* (\024\022\024\035\024 \024\007\027\024\005 \n\017\027\031\021\t \(\007\017\ \026\023\026\024\027 \024\021 40 \007\024)Tj /Span<>> BDC ( )Tj EMC (70 \f\036\022\031\027\007\). )Tj 0.187 Tw 23.244 64.543 Td [(\200\f\036 \031\004\026\f\021\027\017\022\017 )0.5(\017\027\021\036\030\r\034\033 )0.5(\024\021\n\036\021\017\035\017, \004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b )Tj 0.04 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\t \017\n \031\007\026\035\024\f\034 \024\021\030\026\ \017\021\034 \024\f\024\002\036\027\027\024\f\021\017 \f\r\024\036\020\024\ )Tj -0.003 Tw T* [(\f\024\f\021\024\016\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.204 0 Td [(\024\021\n\036\021\017\035\017 )0.6(\f\024\024\021\r\036\021\f\021\r\017\036 )0.5(\r\024\023\030\024\f\024\r )0.5(\031\030\024\r\027\033 )]TJ 0.143 Tw -5.204 -1.218 Td [(\017\b )0.5(\024\002\030\026\024\r\026\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.942 0 Td [(\r\020\035\016\007\026\n )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.472 0 Td [(\002\024\035\036\027\034. )0.6(\231\022\026\035\t, )0.5(\017\f)]TJ 0 Tw (-)Tj 0.131 Tw -13.414 -1.218 Td (\023\024\035\034\024\r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\210\222\200, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \031\004\026\f\021\027\017\022\024\r, \023\024\027\ \016\021)Tj 0 Tw (-)Tj 0.071 Tw T* (\027\t, \007\026\033\021 \r\024\n\024\032\027\024\f\021\034 \024\021\030\ \026\017\021\034 \f\021\036\023\036\027\034 \r\t\030\026\032\036\027\027\ \024)Tj 0 Tw (-)Tj 0.272 Tw 0 -1.218 TD (\f\021\017 \f\017\n\023\021\024\n\024\r/\023\030\024\002\035\036\n, \024\ \002\031\f\035\024\r\035\036\027\027\t\b \002\024\035\036\027\034\033. \ )Tj 0.096 Tw 0 -1.218 TD [(\215\036\030\036\004\036\027\034 )0.5(\f\017\n\023\021\024\n\024\r \002\024\035\036\027\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\2121 \023\024\004\021\017 \023\024\035\027\024\f\021\034\033 )Tj 0.005 Tw T* (\f\024\024\021\r\036\021\f\021\r\024\r\026\035 \024\032\017\007\026\027\017\ \016\n \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\030\036\007\f\021\026\r)Tj 0 Tw (-)Tj 0.074 Tw T* (\035\036\027\017\016\n \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\016\b \020\036\n\024\030\030\024\016:\ \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\253\r\t\007\036\035\036)Tj 0 Tw (-)Tj 0.058 Tw T* (\027\017\017 \022\030\024\r\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\020\024 \023\030\024\b\024\007\026\273 \002\t\035 \023\ \024\027\016\021\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\035\036)Tj 0 Tw (-)Tj 0.149 Tw T* (\r\026\027\021\036\027 \007\035\016 10 \017)Tj /Span<>> BDC ( )Tj EMC (10 \024\023\030\024\001\036\027\027\t\b, \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \253\002\024\035\017 )Tj 0.029 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 \026\007\027\036\020\024 )0.5(\023\030\024\b\024\007\026\273)]TJ /Span<>> BDC ( )Tj EMC 11.917 0 Td [(\227 )0.5(\007\035\016 \007\036\r\016\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.239 0 Td (\007\036\f\016\021\017, )Tj -0.035 Tw -19.156 -1.218 Td (\024)Tj /Span<>> BDC ( )Tj EMC [(\253\r\t\023\026\007\036\027\017\017 \020\036\n\024\030\030\024\017\007\026\ \035\034\027\t\b \031\035\024\r/\024\013\031\013\036\027\017\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\002\031\b\026\027\017\016\273)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \r\024\f\034\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017, \024)Tj /Span<>> BDC ( )Tj EMC (\253\031\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.127 Tw T* (\026\007\027\036\020\024 \023\030\024\b\024\007\026\273)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \f\036\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017 \023\026\006\017\036\027\021\024\r )Tj 0.114 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\034\022\024 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \253\r\024\007\016\027\017\f\021\t\b \r\t\007\ \036\035\036\027\017\005 )Tj 0.046 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\020\024 \023\030\024\b\024\007\026\273 \002\t\035 \030\ \036\035\036\r\026\027\021\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\016\021\036\027 \021\030\036\n )Tj 0.022 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017 \024\023\030\024\001\036\027\027\t\b. \221\030\017\ \031\022\026\026\027\027\t\b \023\026\006\017\036\027\021\026 \f\022\026\ )Tj 0 Tw (-)Tj 0.058 Tw T* (\026\035\017, \004\021\024 \007\026\027\027\t\005 \f\017\n\023\021\024\n\ \017\n \027\026\022\024\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \021\024\035\034)Tj 0 Tw (-)Tj 0.079 Tw T* (\022\024 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031\022\026\026\035, \004\021\024 \017\n\036\036\021 \f\024\ \002\f\021\r\036\027\027\t\005 \024\023\t\021, )Tj 0.017 Tw T* (\f\r\016\026\027\027\t\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\007\016\027\017\f\021\t\n\017 \r\t\007\036\035\036\027\017\016\n\017\ . )0.5(\210\f\021\026\r\001\017\036\f\016 )]TJ 0.088 Tw T* (\f\036\n\034 \030\036\f\023\024\027\007\036\027\021\024\r, \031\022\026\ \026\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \024\027\017 \027\036 \017\n\036\035\017 )Tj 0.072 Tw T* (\024\023\t\021\026 \027\026\035\017\004\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031\022\026\026\027\027\024\020\024 \f\017\n\023\021\024\n\026\ \020\036\n\024\030\030\024\016 )Tj 0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\220\021\024\n\031 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\017 \r\024\007\016\027\017\f\021\t\ \b \r\t\007\036)Tj 0 Tw (-)Tj -0.055 Tw T* (\035\036\027\017\005 \r\t\t\r\026\035 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \027\036\022\024\021\024\030\024\036 \026\021\030\031\007\027\ \036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\036.)Tj 0.218 Tw T* (\200\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\026\007\036\027\017\017 \020\036\n\024\030\030\024\017\007\026\035\ \034\027\t\b \031\035\024\r \(\206\211\)/)Tj 0.83 Tw T* (\024\013\031\013\036\027\017\017 \r\t\002\031\b\026\027\017\016 \r\t\t\r\ \026\035 \026\n\036\001\026\021\036\035\034\f\021\r\024 )Tj 0.24 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \023\030\017\004\017\027. \210\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \002\t\035\024, )Tj 0.578 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \027\036\022\024\021\024\030\t\b \030\036\f\023\024\ \027\007\036\027\021\024\r, \024\002\255\036\007\017\027\036)Tj 0 Tw (-)Tj 0.147 Tw T* (\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\024\023\030\024\f\036 \007\r\031\b \f\017\n\023\021\024\ \n\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027 \024\002\013\017\005. )Tj 0.281 Tw T* (\211\022\026\026\027\027\t\005 \r\024\023\030\024\f \027\036 \r\t\t\r\026\ \035 \f\035\024\032\027\024\f\021\036\005 \021\024\035\034\022\024 )Tj 0.15 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \021\016\032\036\035\t\n\017 \f\021\026\007\017\016\ \n\017 \020\036\n\024\030\030\024\016: )Tj 0.03 Tw T* [(III )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(IV )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(Gol)-30.9(igher \(5/10, )0.5(50%\), )0.5(\r\r\017\007\031 \027\026\035\017\004\017\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC (\027\017\b )Tj 0.164 Tw T* (\024\023\t\021\026 \032\017\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\n\017 \f\024\f\021\024\016\027\017\016\n\017, \022\026\022\ \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\026\007\036)Tj 0 Tw (-)Tj 0.048 Tw T* (\027\017\036\n \206\211, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f \024\013\031\013\036\027\017\036\n \r\t\002\031\b\026\027\017\016, \022\ \024\021\024\030\t\036 \024\027\017 )Tj 0.239 Tw T* (\f\r\016\t\r\026\033\021 \n\036\032\007\031 \f\024\002\024\005 \022\026\ \022 \024\021\030\026\032\036\027\017\036 \030\026\035\017\004\027\024\005\ )Tj 0.341 Tw T* (\f\021\036\023\036\027\017 \r\t\030\026\032\036\027\027\024\f\021\017 \024\ \007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\020\024 \032\036 \f\024\f\021\024\016)Tj 0 Tw (-)Tj -0.016 Tw T* (\027\017\016)Tj /Span<>> BDC ( )Tj EMC 1.717 0 Td [(\227 )0.6(\r\024\r\035\036\004\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.946 0 Td [(\023\026\021\024\035\024\020\017\004\036\f\022\017\005 )0.6(\023\030\024\006\036\f\f )0.6(\206\211. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 12.567 0 Td (\021\024 )Tj 0.059 Tw -21.23 -1.218 Td (\032\036 \r\030\036\n\016 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\253\035\036\020\022\024\005\273 \022\035\017\027\017\004\036\f\022\024\005\ \235\024\030\n\024\005 )Tj 0.187 Tw T* (\020\036\n\024\030\030\024\016 \004\026\013\036 \030\026\007\031\n\t\r\026\ \035\017 \027\026\007 \021\036\n, \022\026\022 \023\030\026\r\017\035\034\ )Tj 0 Tw (-)Tj 0.14 Tw T* [(\027\024 )0.5(\024\021\r\036\021\017\021\034, )0.6(\036\f\035\017 )0.5(\027\026\002\031\b\026\027\017\036 )0.5(\036\f\021\034, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 15.567 0 Td [(\r\t\023\026\007\036\027\017\016 )0.5(\027\036\021. )]TJ 0.221 Tw -15.567 -1.218 Td [(\215\024\f\035\036 \024\002\f\031\032\007\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.324 0 Td [(\030\026\002\024\004\036\005 \020\030\031\023\023\036 )0.5(\002\t\035\024 \030\036\001\036\027\024 )]TJ 0.21 Tw -9.324 -1.218 Td (\024\021\f\036\023\026\030\017\030\024\r\026\021\034 \007\r\026 \r\t\001\ \036 \024\002\024\027\026\004\036\027\027\t\b \f\024\f\021\024\016\027\017\ \016 )Tj 0.051 Tw T* [(\023\031\021\036\n )0.5(\026\n\036\027\t \027\026\022\026 )0.5(\253/\273 \n\036\032\007\031 )0.5(\027\017\n\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\253\017/\017\035\017\273, )0.5(\004\021\024 )]TJ 0.25 Tw T* [(\023\024\n\024\032\036\021 \023\026\006\017\036\027\021\031 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.339 0 Td (\024\021\r\036\021\036 \027\026)Tj /Span<>> BDC ( )Tj EMC 4.607 0 Td (\r\024\023\030\024\f \024\021\007\036\035\034\027\024 )Tj 0.089 Tw -14.946 -1.218 Td (\031\004\017\021\t\r\026\021\034 \f\r\024\005 \024\023\t\021 \027\026\035\ \017\004\017\016 \022\026\022 \r\t\023\026\007\036\027\017\016 \206\211,\ \021\026\022 )Tj -0.038 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\013\031\013\036\027\017\016 \r\t\002\031\b\026\027\017\016, \017\035\ \017 \024\002\024\017\b \f\017\n\023\021\024\n\024\r \r\n\036\f\021\036.\ )Tj 0.077 Tw T* (\212\030\031\020\024\005 \023\030\017\004\017\027\024\005 \026\n\036\001\ \026\021\036\035\034\f\021\r\026 \016\r\017\035\024\f\034 \021\024, \004\ \021\024 \r\024 )Tj 0.042 Tw T* (\r\030\036\n\016 \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \030\036\f\023\024\027\007\036\027)Tj 0 Tw (-)Tj -0.009 Tw T* (\021\024\r \(2/10\) \r\024\027\017\022\026\035\026 \023\031\021\026\027\ \017\006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021\036, \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.211 Tw T* (\017\b \f\023\030\026\001\017\r\026\035\017: \004\026\f\021\034 \023\026\ \006\017\036\027\021\024\r \f\004\017\021\026\035\024, \004\021\024 \030\ \036\004\034 )Tj 0.068 Tw T* (\017\007\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\024 \027\026\002\031\b\026\027\017\017, \022\ \024\021\024\030\024\036 \024\027\017 \024\013\031\013\026\033\021 )Tj 0.112 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\023\017\030\024\r\026\027\017\017, \007\030\031\020\017\ \036 \032\036 \f\004\017\021\026\035\017, \004\021\024 \030\036\004\034 \ \024\002 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (138)Tj ET endstream endobj 700 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \213\212\217\r)10(\025\b\025\221 \n\022\r\005\025\016\016-\r\002\020\200)21(\026)-19.9(\002\005\t\025\221 \b\017\020\n\202\017\n\n )]TJ 0 -1 TD [(\025\224\005\025\016\t\n\r\017 PRO)20(M-HIS)21(S \202)-21(\020\213 \224\017\n\004\t\026)11(\025\b \016\022\013)10(\004\024\025\005\005\025\004\024)]TJ 39.217 1 Td [(Results of\022linguistic and cr)20(oss-cultur)21(al v)10(alidation of\022th)11(e )]TJ 21.255 0 Td ( )Tj -25.84 -1 Td [(PRO)20(M-HIS)21(S questionnair)31.1(e for patients with h)11(emorrh)11(oidal disease)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.129 Tw 10 0 0 10 42.5197 724.8299 Tm (\r\022\035\033\004\017\r\001\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \007\r\031\b \023\030\036\007\f\021\026\r\017\021\036\035\ \036\005 \017\027\017\006\017\017\030\031)Tj 0 Tw (-)Tj 0.15 Tw 0 -1.218 TD (\033\013\036\005 \f\021\024\030\024\027\t \(\202\210 \253\222\036\030\r\034\ \036\273, \217\024\f\f\017\016\), \024\007\027\024\020\024 \023\030\026\022\ )Tj 0 Tw (-)Tj 0.324 Tw T* [(\021\017\022\031\033\013\036\020\024 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\026 \f)]TJ /Span<>> BDC ( )Tj EMC (\024\023\t\021\024\n \024\030\020\026\027\017\026\006\017\017 )Tj 0.608 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 \027\026\031\004\027\024-\017\f\f\ \035\036\007\024\r\026\021\036\035\034\f\022\024\005 \030\026\002\024\021\ \t )Tj 0.072 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.778 0 Td [(\220\021\024\005 )0.6(\024\002\035\026\f\021\017, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.737 0 Td [(\007\r\031\b )0.5(\023\036\030\036\r\024\007\004\017\022\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 9.037 0 Td (\020\024\035\035\026\027\007\f\022\024\020\024 )Tj -0.042 Tw -16.553 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005. \212\r\026 \027\036\026\r\017\f\017\n\t\b \023\ \036\030\036\r\024\007\004\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007)Tj 0 Tw (-)Tj 0.172 Tw 0 -1.218 TD (\f\022\024\020\024 \016\t\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \(\024\002\026 \024\002\035\026\007\026\035\017\ \007\035\017\021\036\035\034\027\t\n )Tj 0.175 Tw 0 -1.218 TD [(\024\023\t\021\024\n )0.5(\023\036\030\036\r\024\007\024\r )0.6(\n\036\007\017\006\017\027\f\022\017\b )0.6(\021\036\022\f\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.469 0 Td (\020\024\035\035\026\027\007)Tj 0 Tw (-)Tj 0.142 Tw -18.469 -1.218 Td (\f\022\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005\) \r\t\023\024\035\027\017\035\017 \023\030\016\ \n\024\005 \023\036\030\036\r\024\007 \024\030\017)Tj 0 Tw (-)Tj 0.292 Tw T* [(\020\017\027\026\035\034\027\024\005 )0.5(\r\036\030\f\017\017 \024\023\030\024\f\027\017\022\026, \023\030\036\f\035\ \036\007\031\016 )0.5(\024\f\027\024\r\027\024\005 )]TJ 0.2 Tw T* (\026\007\026\004\036\005 \n\026\022\f\017\n\026\035\034\027\024 \021\024\ \004\027\031\033 \021\036\022\f\021\024\r\031\033 \026\007\026\023\021\026\ \006\017\033 )Tj 0.172 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\023\021\031\026\035\034\027\t\n \023\036\030\036\027\ \024\f\024\n \f\n\t\f\035\024\r, \024\021\030\026\032\036\027\027\t\b )Tj 0.1 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\030\017\020\017\027\026\035\034\027\024\005 \r\036\030\f\017\017 \024\ \023\030\024\f\027\017\022\026 PROM-HIS)17(S, \r)]TJ /Span<>> BDC ( )Tj EMC (\036\020\024 )Tj 0.188 Tw 0 -1.218 TD (\030\031\f\f\022\024\016\t\004\027\031\033 \r\036\030\f\017\033. \217\036\ \031\035\034\021\026\021\024\n \007\026\027\027\024\020\024 \220\021\026\ \023\026 )Tj 0.291 Tw 0 -1.218 TD (\016\r\017\035\024\f\034 \f\024\007\026\027\017\036 \007\r\031\b \r\036\ \030\f\017\005 \023\030\016\n\024\020\024 \023\036\030\036\r\024\007\026\ : )Tj -0.012 Tw T* (\023\030\016\n\024\005 \023\036\030\036\r\024\007 \215\215)Tj /Span<>> BDC ( )Tj EMC (\227 1.1 \017)Tj /Span<>> BDC ( )Tj EMC (\215\215)Tj /Span<>> BDC ( )Tj EMC (\227 1.2, \022\024\021\024\030\t\036 \026\021\036\n )Tj -0.018 Tw T* (\002\t\035\017 \024\002\255\036\007\017\027\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\036\030\f\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036. )Tj 0.063 Tw T* (\221\026\022 \032\036, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\r \024\030\017\020\017\027\026\035\034\027\024\n \024\023\030\024\f\027\ \017\022\036 PROM-HIS)17.1(S, )]TJ 0.236 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\031\f\f\022\024\016\t\004\027\024\005 \024\002\255\036\ \007\017\027\036\027\027\024\005 \r\036\030\f\017\017 \f\024\007\036\030\ )Tj 0 Tw (-)Tj 0.081 Tw T* (\032\026\035\024\f\034 \021\030\017 \007\024\n\036\027\026 \(\212\): 1\)\ )Tj /Span<>> BDC ( )Tj EMC (\222\017\n\023\021\024\n\t \020\036\n\024\030\030\024\016 \(\2121\), )Tj 0.238 Tw T* (2\))Tj /Span<>> BDC ( )Tj EMC (\200\035\017\016\027\017\036 \020\036\n\024\030\030\024\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\024\f\021\ \034 )Tj 0.119 Tw T* (\(\2122\) \017)Tj /Span<>> BDC ( )Tj EMC (3\))Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\034 \035\036\004\ \036\027\017\036\n \(\2123\). \2121 \f\024)Tj 0 Tw (-)Tj 0.019 Tw T* [(\007\036\030\032\026\035 \023\016\021\034 )0.5(\027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\t\b \024\002\255\036\022\021\017\r\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\031\002\255\036\022)Tj 0 Tw (-)Tj 0.043 Tw T* [(\021\017\r\027\t\b \f\017\n\023\021\024\n\024\r \026\002\024\035\036\r\026\ \027\017\016, )0.5(\r\t\030\026\032\036\027\027\024\f\021\034 \022\024\021\024)]TJ 0 Tw (-)Tj -0.069 Tw T* (\030\t\b \023\026\006\017\036\027\021 \024\006\036\027\017\r\026\035 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (5-\002\026\035\035\034\027\024\005 \001\022\026\035\036 \214\026\005\022\ \036\030\021\026, )Tj -0.046 Tw T* (\021\024\020\007\026 \022\026\022 \2122 \017)Tj /Span<>> BDC ( )Tj EMC (\2123 \r\022\035\033\004\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n\031 \r\024\023\030\024\f\031, )Tj 0.037 Tw T* (\024\021\r\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\036 \023\030\036\007\023\024\035\026\020\026\035\024\ \f\034 \007\026\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.017 Tw T* (\027\017\036\n 10-\002\026\035\035\034\027\024\005 \004\017\f\035\024\r\024\ \005 \001\022\026\035\t \024\006\036\027\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.421 Tw T* (\036\007\017\027\036\027\017\017 \007\r\031\b \023\030\016\n\t\b \023\036\ \030\036\r\024\007\024\r \023\024\021\030\036\002\024\r\026\035\024\f\034\ )Tj 0.195 Tw T* (\024\002\f\031\032\007\036\027\017\036 \027\036\022\024\021\024\030\t\b \ \024\023\030\036\007\036\035\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004)Tj 0 Tw (-)Tj 0.225 Tw T* (\027\024\005 \r\036\030\f\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \022)Tj /Span<>> BDC ( )Tj EMC (\031\021\r\036\030\032\007\036\027\017\033 \021\024\020\024, \004\021\024\ )Tj 0.046 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \024\023\030\024\f\027\017\022\036 \027\036\021 \023\ \030\026\r\017\035\034\027\t\b \017\035\017 \027\036\023\030\026\r\017\035\ \034)Tj 0 Tw (-)Tj 0.065 Tw T* (\027\t\b \024\021\r\036\021\024\r \002\t\035\024 \030\036\001\036\027\024\ \007\024\002\026\r\017\021\034 \235\030\026\031 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 )Tj 0.009 Tw T* (\023\026\006\017\036\027\021\031 \023\030\036\007\035\026\020\026\036\021\ \f\016 \r\t\002\030\026\021\034 \021\024\021 \r\026\030\017\026\027\021,\ \022\024\021\024\030\t\005 )Tj 0.133 Tw T* (\253\027\026\017\002\024\035\036\036 \021\024\004\027\024 \024\021\030\026\ \032\026\036\021 \036\020\024 \f\024\f\021\024\016\027\017\036\273. \217\ \026\002\024\004\026\016 )Tj 0.082 Tw T* [(\020\030\031\023\023\026 )0.5(\023\024\f\004\017\021\026\035\026, )0.6(\004\021\024 )0.5(\021\026\022\024\036 )0.6(\007\024\002\026\r\035\036\027\017\036 )0.5(\027\026\023\030\026\r\035\036\027\024 )]TJ 0.144 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \016\f\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\024\036 \007\035\016 \030\024\f\f\017\005\f\022\024\020\ \024 \023\026\006\017\036\027\021\026 )Tj 0.024 Tw T* (\r\024\f\023\030\017\016\021\017\036 \026\007\026\004\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\033 \007\026\027\027\024\020\024 \024\023\ \030\024\f\027\017)Tj 0 Tw (-)Tj 0.157 Tw T* (\022\026. \212\026\035\036\036, \030\026\002\024\004\026\016 \020\030\031\ \023\023\026 \024\002\f\031\007\017\035\026 \r\024\027\017\022\001\017\036\ \023\024)Tj 0 Tw (-)Tj 0.131 Tw T* (\f\035\036 \023\036\030\036\r\024\007\026 \030\026\f\b\024\032\007\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016\b \f\021\036\023\036\027\017\ )Tj 0.18 Tw T* (\r\t\030\026\032\036\027\027\024\f\021\017 \f\017\n\023\021\024\n\024\r,\ \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\023\030\026\001\017\r\026\035\024\f\034 )Tj 0.127 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\2121. \202)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024, \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f, \007\024\f\035\024\r\027\024 \023\036\030\036\r\024\ \007\016\013\017\005)Tj 0 Tw (-)Tj 0.108 Tw T* (\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \022\026\022 \253\200 \022\026\022\024\005 \f\021\ \036\023\036\027\017 \r\t \017\f\023\t\021\t\r\026\035\017 )Tj 0.076 Tw T* [(\023\030\017\r\036\007\201\027\027\t\036 )0.6(\027\017\032\036 )0.5(\032\026\035\024\002\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.109 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.6(\023\030\024\001\035\024\005 )]TJ 0.123 Tw -13.109 -1.218 Td (\027\036\007\036\035\017?\273 \r)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\f\017\017 \024\007\027\024\020\024 \023\036\030\036\r\024\007\ \004\017\022\026 \031\023\024\n\016\027\031\021\t\036 )Tj 0.1 Tw T* (\f\021\036\023\036\027\017 \002\t\035\017 \r\t\030\026\032\036\027\t \004\ \036\030\036 \022\026\004\036\f\021\r\036\027\027\t\036 \b\026\030\026\022\ )Tj 0 Tw (-)Tj 0.267 Tw T* (\021\036\030\017\f\021\017\022\017 \253\027\036\027\026\004\017\021\036\ \035\034\027\024\273, \253\031\n\036\030\036\027\027\024\273, \253\f\017\ \035\034\027\024\273, )Tj 0.111 Tw T* (\253\024\004\036\027\034 \f\017\035\034\027\024\273 \017\035\017 \253\024\ \021\f\031\021\f\021\r\024\r\026\035\017\273, \021\024\020\007\026 \022\026\ \022 \r\021\024)Tj 0 Tw (-)Tj 0.232 Tw T* (\030\024\005 \023\036\030\036\r\024\007\004\017\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \032\036 \r\024\023\030\024\f, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\036, )Tj 0.092 Tw T* (\023\030\036\007\024\f\021\026\r\017\035 \r\026\030\017\026\027\021\t \024\ \021\r\036\021\024\r \f\022\024\030\036\036 \031\022\026\t\r\026\033\013\ \017\b )Tj 0.185 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \017\b \r\024\027\017\022\027\024\r\036\027\017\ \016: \253\023\030\026\022\021\017\004\036\f\022\017 \027\017\022\024\020\ )Tj 0 Tw (-)Tj -0.042 Tw T* (\007\026\273, \253\024\004\036\027\034 \030\036\007\022\024\273, \253\030\ \036\007\022\024\273, \253\004\026\f\021\024\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\024\004\036\027\034 \004\026\f\021\024\273. )Tj 0.068 Tw T* [(\217\026\002\024\004\036\005 )0.5(\020\030\031\023\023\024\005 )0.6(\002\t\035\024 )0.5(\030\036\001\036\027\024 )0.5(\023\030\017\007\036\030\032\017\r\026\021\034\f\016 )0.6(\r\036\030)]TJ 0 Tw (-)Tj 0.125 Tw T* [(\f\017\017 )0.5(\023\036\030\036\r\024\007\026 )0.6(\023\036\030\r\024\020\024 )0.5(\023\036\030\036\r\024\007\004\017\022\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.235 0 Td [(\f\017\035\031 )0.5(\021\024\020\024, )0.6(\004\021\024 )]TJ -0.016 Tw 7.009 64.543 Td (\024\027\026 \n\026\022\f\017\n\026\035\034\027\024 \f\024\024\021\r\036\ \021\f\021\r\031\036\021 \027\026\004\036\027\017\016\n \024\023\030\036\ \007\036\035\036)Tj 0 Tw (-)Tj 0.078 Tw T* (\027\017\005, \017\f\023\024\035\034\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\005 \r\036\030\f\017\017 \024\ \023\030\024\f)Tj 0 Tw (-)Tj 0.309 Tw T* (\027\017\022\026, \026)Tj /Span<>> BDC ( )Tj EMC 3.684 0 Td [(\021\026\022\032\036 )0.5(\023\024\021\024\n\031, \004\021\024 \r\t\030\026\032\036\027\027\024\f\021\ \034 )0.6(\r\035\017\016\027\017\016 )]TJ 0.038 Tw -3.684 -1.218 Td (\031\022\026\026\027\027\t\b \f\017\n\023\021\024\n\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \035\031\004\001\036 \023\036\030\036\007\ \026\036\021\f\016 )Tj 0 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\n\017 \b\026\030\026\022\021\036\030\ \017\f\021\017\022\026\n\017.)Tj 0.294 Tw T* (\215\036\030\036\r\024\007\t \f\026\n\017\b \f\017\n\023\021\024\n\024\r\ , \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\023\030\026\001\017\r\026)Tj 0 Tw (-)Tj -0.008 Tw 0 -1.218 TD (\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\2121 \021\026\022\032\036 \023\024\021\030\036\002\024\r\026\035\017 \024\ \002\f\031\032\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\016\021\017\016 )Tj 0.268 Tw 0 -1.218 TD [(\022\024\027\f\036\027\f\031\f\027\024\020\024 \030\036\001\036\027\017\016\ )0.5(\024\002 \024\022\024\027\004\026\021\036\035\034\027\024\005 \r\036\030\ \f\017\017. )]TJ 0.201 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \002\t\035\024 \030\036\001\036\027\024\ , \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\026\b \024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b )Tj 0.174 Tw T* (\f\017\n\023\021\024\n\026\b, \022\026\022 \253\207\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\027\031\f\026\273, \253\003\031\007 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 0.047 Tw T* (\035\026\f\021\017 \026\027\031\f\026\273 \017\035\017 \253\200\024\007\016\ \027\017\f\021\t\036 \r\t\007\036\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\031\f\026\273, )Tj 0.022 Tw T* (\023\030\036\007\f\021\026\r\035\016\033\013\017\b \007\024\f\035\024\r\027\ \t\005 \023\036\030\036\r\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024, )Tj 0.126 Tw 0 -1.218 TD (\002\024\035\036\036 \023\024\007\b\024\007\016\013\017\n \007\035\016 \030\ \024\f\f\017\005\f\022\024\020\024 \023\026\006\017\036\027\021\026 \002\ \031\007\036\021 )Tj 0.133 Tw 0 -1.218 TD (\026\n\036\027\026 \f\035\024\r\026 \253\026\027\031\f\273 \027\026)Tj /Span<>> BDC ( )Tj EMC (\253\026\007\027\017\005 \023\030\024\b\024\007\273. \200)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024)Tj 0 Tw (-)Tj 0.035 Tw 0 -1.218 TD (\f\036, \024\023\017\f\t\r\026\033\013\036\n \027\026\035\017\004\017\036\ \r\t\023\026\007\036\027\017\016 \017\035\017 \027\026\002\031\b\026\027\ \017\016 )Tj 0.277 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\007\027\036\020\024 \023\030\024\b\024\007\ \026, \007\024\f\035\024\r\027\024: \253\210\013\031\013\036\027\017\036\ )Tj 0.171 Tw T* [(\r\t\023\016\004\017\r\026\027\017\016/\023\030\017\023\031\b\035\024\f\021\ \017 )0.7(\026\027\031\f\026\273, )0.5(\030\026\002\024\004\036\005 )0.5(\020\030\031\023\023\024\005 )]TJ T* (\002\t\035\024 \030\036\001\036\027\024, \004\021\024 \n\026\022\f\017\n\ \026\035\034\027\024 \007\024\f\035\024\r\027\t\005 \023\036\030\036\r\024\ \007 )Tj 0.093 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024 \027\036 \023\024\r\024\035\ \017\021 \024\021\030\026\017\021\034 \f\n\t\f\035 \f\017\n\023\021\024\ )Tj 0 Tw (-)Tj 0.064 Tw T* (\n\024\r, \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\023\030\026\001\017\r\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \021\024\020\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.077 Tw T* (\235\036\f\f\017\024\027\026\035\034\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\f\022\024\n \f\024\024\002\013\036\f\021\r\026\ \b \217\205 \031\023\024)Tj 0 Tw (-)Tj 0.241 Tw T* (\021\030\036\002\035\016\036\021\f\016 \007\030\031\020\026\016 \021\036\ \030\n\017\027\024\035\024\020\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \f\035\031\004\026\036 )Tj -0.027 Tw T* (\002\t\035\024 \030\036\001\036\027\024 \024\021\024\005\021\017 \024\021\ \007\024\f\035\024\r\027\024\020\024 \023\036\030\036\r\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024)Tj 0 Tw (-)Tj -0.003 Tw T* (\027\031 \002\024\035\036\036 \022\024\027\006\036\023\021\031\026\035\034\ \027\024\020\024, \022\024\021\024\030\t\005 \023\024\r\024\035\016\036\ \021 \f\024\b\030\026)Tj 0 Tw (-)Tj 0.011 Tw T* (\027\017\021\034 \022\026\022 \f\n\t\f\035, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\034 \024\030\017\020\017\027\026\035\034\027\024\ \020\024 \r\024\023\030\024)Tj 0 Tw (-)Tj 0.13 Tw T* [(\f\026: \253\200\t\023\026\007\036\027\017\036 \020\036\n\024\030\030\024\ \017\007\026\035\034\027\t\b )0.5(\031\035\024\r /\024\013\031\013\036\027\017\036 )]TJ 0 Tw T* (\027\026\002\031\b\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\007\027\036\020\024 \023\030\024\b\024\007\ \026\273.)Tj 0.041 Tw T* (\200 \r\024\023\030\024\f\036 \2122 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \027\026\f\022\024\035\034\022\024 \023\036\030\036\004\017\f\ \035\036\027\027\t\036 \f\017\n\023)Tj 0 Tw (-)Tj 0.214 Tw T* (\021\024\n\t \r\035\017\016\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \023\024\r\f\036\007\027\036\r\027\024\005 \ \032\017\027\017 \023\026)Tj 0 Tw (-)Tj 0.314 Tw T* (\006\017\036\027\021\024\r, \007\017\f\022\031\f\f\017\016 \r\024\027\017\ \022\035\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\036\030\036\r\024\007\026 )Tj 0.273 Tw T* [(\023\030\024\017\r\024\007\027\024\020\024 \024\021 \020\024\035\035\026\ \027\007\f\022\024\020\024 \020\035\026\020\024\035\026 \253gehindr)-24(e\273, )]TJ 0.137 Tw T* (\007\024\f\035\024\r\027\024 \023\036\030\036\r\024\007\016\013\036\020\024\ \f\016 \022\026\022 \253\n\036\001\026\021\034 \004\036\n\031-\035\017\002\ \024\273. )Tj 0.194 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\f\017\017 \024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\004\017\022\024\r, \f\024\007\036\030\032\026\ \035\f\016 \007\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\035\024\r\027\t\005 \023\036\030\036\r\024\007 \031\022\026\026\027\027\ \024\020\024 \020\035\026\020\024\035\026, \021\024\020\007\026 \022\026\ \022 \007\030\031)Tj 0 Tw (-)Tj 0.109 Tw T* [(\020\024\005 \023\036\030\036\r\036\035 )0.5(\036\020\024 \022\026\022 \253\026\021\030\031\007\027\016\021\034 )0.5(\004\021\024-\035\017\002\024\273. )0.5(\217\036\001\036\027\024 )]TJ 0.049 Tw T* (\017\f\023\024\035\034\024\r\026\021\034 \020\035\026\020\024\035 \253\ \026\021\030\031\007\027\016\021\034\273, \021\026\022 \022\026\022 \024\ \027 \027\026\017\002\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\035\036\036 \023\024\027\016\021\036\027 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\n\t\f\035\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\036 \024)Tj /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\017 \f\017\n\023)Tj 0 Tw (-)Tj 0.103 Tw T* (\021\024\n\024\r \002\024\035\036\027\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\036 \026\f\023\036\022\021\t \023\024\r\f\036\ \007\027\036\r\027\024\005 )Tj 0.305 Tw T* [(\032\017\027\017. )0.5(\221\026\022\032\036, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\f\031\032\007\036\027\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\002\024\004\036\005 )0.5(\020\030\031\023\023\036 )]TJ 0.284 Tw T* [(\023\036\030\036\r\024\007\024\r \007\r\031\b \023\024\035\016\030\027\t\ \b \f\021\036\023\036\027\036\005 )0.5(\r\t\030\026\032\036\027\027\024\f\021\017 )]TJ 0.435 Tw T* (\031\023\024\n\016\027\031\021\024\020\024 \253\026\021\030\031\007\027\ \036\027\017\016\273, \022\024\021\024\030\t\036 \017\f\023\024\035\034\ \031\033\021)Tj 0 Tw (-)Tj 0.122 Tw T* (\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \214\026\005\022\036\030\021\026, \002\t\035\024 \030\ \036\001\036\027\024 \023\030\017\007\036\030\032\017\r\026\021\034\f\016\ )Tj -0.002 Tw T* (\r\036\030\f\017\005 \253\f\024\r\036\030\001\036\027\027\024 \027\036 \ \026\021\030\031\007\027\016\035\017\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\022\030\026\005\027\036 \f\017\035\034)Tj 0 Tw (-)Tj 0.332 Tw T* [(\027\024 )0.5(\026\021\030\031\007\027\016\035\017\273 )0.6(\r\n\036\f\021\024 )0.5(\253\023\030\026\022\021\017\004\036\f\022\017 )0.6(\027\036 )0.5(\n\036\001\026\035\017\273 )]TJ -0.012 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\253\024\004\036\027\034 \n\036\001\026\035\017\273 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\035\031 \030\026\027\036\036 \031\023\024\n\016\027\031\021\024\005\ \023\030\017\004\017\027\t.)Tj -0.066 Tw T* (\212\017\f\022\031\f\f\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\031 \r\024\023\030\024\f\026 \2123, \022\026\f\ \026\033\013\036\020\024\f\016 \023\030\024)Tj 0 Tw (-)Tj 0.321 Tw T* [(\b\024\032\007\036\027\017\016 )0.6(\024\023\030\026\001\017\r\026\036\n\t\n )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016, )]TJ 0.21 Tw T* (\022\024\f\027\031\035\026\f\034 \027\036\024\002\b\024\007\017\n\024\f\021\ \017 \024\021\024\005\021\017 \024\021 \023\030\016\n\024\020\024 \023\036\ \030\036)Tj 0 Tw (-)Tj 0.104 Tw T* [(\r\024\007\026 )0.5(\027\026\r\026\027\017\005 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\r\n\036\001\026\021\036\035\034\f\021\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.238 0 Td (\024\030\017)Tj 0 Tw (-)Tj 0.017 Tw -20.238 -1.218 Td (\020\017\027\026\035\034\027\024\020\024 \024\023\030\024\f\027\017\022\026\ , \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \002\024\035\036\036 \031\021\024\004\027\036\ \027\027\024\020\024. )Tj -0.036 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \r\n\036\f\021\024 \024\002\013\036\020\ \024 \024\023\030\036\007\036\035\036\027\017\016 \253\024\023\036\030\026\ \006\017\016\273, )Tj 0.087 Tw T* (\004\021\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \022\024\035\024\023\030\024\022\021\024\035\024\020\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \023\030\036\007\f\021\026\r\017\021\036)Tj 0 Tw (-)Tj -0.044 Tw T* (\035\036\005 \017\027\017\006\017\017\030\031\033\013\036\005 \f\021\024\ \030\024\027\t, \r\b\024\007\016\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r \030\026\002\024)Tj 0 Tw (-)Tj -0.035 Tw T* (\004\036\005 \020\030\031\023\023\t, \002\031\007\036\021 \007\035\016 \030\ \024\f\f\017\005\f\022\024\020\024 \023\026\006\017\036\027\021\026 \016\ \r\035\016\021\034\f\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_2 1 Tf 25 0 0 25 505.5395 56.0378 Tm (137)Tj ET endstream endobj 699 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.159 Tw 10 0 0 10 70.8661 724.8299 Tm (\212\026\035\036\036 \r\t\023\024\035\027\016\035\024\f\034 \024\002\255\ \036\007\017\027\036\027\017\036 \023\024\035\031\004\036\027\027\t\b \023\ \036\030\036)Tj 0 Tw (-)Tj 0.125 Tw 0 -1.218 TD (\r\024\007\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\031 \r\036\030\f\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \f\024\020\035\026\f\024\r\026\027\017\036. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017)Tj 0 Tw (-)Tj 0.259 Tw T* (\004\017\017 \022\026\022\017\b-\035\017\002\024 \016\t\022\024\r\t\b \017\ \035\017 \f\n\t\f\035\024\r\t\b \030\026\f\b\024\032)Tj 0 Tw (-)Tj 0.384 Tw T* [(\007\036\027\017\005, )0.6(\030\026\002\024\004\026\016 )0.5(\020\030\031\023\023\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 11.792 0 Td [(\f\024\f\021\026\r\036 )0.5(\023\030\036\007\f\021\026\r\017\021\036\035\036\005 )]TJ 0.153 Tw -11.792 -1.218 Td (\202\210)Tj /Span<>> BDC ( )Tj EMC (\253\222\036\030\r\034\036\273, \f\023\036\006\017\026\035\017\f\021\026\ \007\030\026\r\024\024\b\030\026\027\036\027\017\016 \f\024 \f\023\036\ )Tj 0 Tw (-)Tj 0.153 Tw T* [(\006\017\026\035\017\026\006\017\036\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\004\017\022\026\(\024\r\) )Tj 0.058 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024, \024\002\f\031\032\007\026\ \035\017 \017\n\036\033\013\017\036\f\016 \030\026\f\b\024\032\007\036\027\ \017\016 )Tj 0.104 Tw 0 -1.218 TD (\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\036 \f\235\024\030\n\017\030\024\r\026\035\017 \024\002\ \255\036\007\017\027\036\027\027\031\033 \f\024\020\035\026\f\024\r\026\027\ )Tj 0 Tw (-)Tj 0.079 Tw T* [(\027\031\033 \r\036\030\f\017\033 \024\023\030\024\f\027\017\022\026 \(\210\ \222\200\) PROM-HIS)17.1(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n )Tj 0 Tw T* (\016\t\022\036.)Tj -0.033 Tw T* (\215\024\f\035\036 \021\024\020\024, \022\026\022 \210\222\200 \002\t\035\ \026 \f\235\024\030\n\017\030\024\r\026\027\026, \r\t\023\024\035\027\036\ \027 \036\036 )Tj 0 Tw T* (\024\002\030\026\021\027\t\005 \023\036\030\036\r\024\007.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 554.3378 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.007 Tw 10 0 0 10 70.8661 529.9818 Tm (\037\036\035\034\033 \220\021\024\020\024 \220\021\026\023\026 \016\r\035\ \016\035\024\f\034 \024\f\031\013\036\f\021\r\035\036\027\017\036 \022\024\ \027\021\030\024\035\016 )Tj 0.179 Tw T* (\022\026\004\036\f\021\r\026 \023\036\030\036\r\024\007\026, \004\021\024\ \023\024\r\024\035\017\035\024 \023\030\017\005\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\026\022\035\033)Tj 0 Tw (-)Tj 0.188 Tw T* (\004\036\027\017\033: \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\027\024\n \023\036\030\036\r\024\007\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\020\036\021\027\024\020\024 \016\t\022\026 )Tj 0.307 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\t\005 \f\n\t\f\035 \017\f\b\024\ \007\027\024\020\024 \024\023\030\024\f\027\017\022\026 \f\024)Tj 0 Tw (-)Tj 0.16 Tw T* (\b\030\026\027\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \024\002\255\036\n\036. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\f\r\024\036\005 \f\031\021\017 )0.5(\007\026\027\027\t\005 )]TJ 0.067 Tw T* (\220\021\026\023 \r\t\023\024\035\027\036\027 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\022\031\f\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\035\024\r\027\t\005 \(\027\036 \022\024\027\006\036\023)Tj 0 Tw (-)Tj 0.129 Tw T* (\021\031\026\035\034\027\t\005\) \023\036\030\036\r\024\007, \024\007\027\ \026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \r\024\023\030\024\f\026\b, \022\024\021\024\030\t\036 )Tj 0.145 Tw T* (\024\021\027\024\f\016\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \f\031\002\255\036\022\021\017\r\027\t\n \021\036\n\ \026\n \(\031\007\024\r\035\036\021\r\024)Tj 0 Tw (-)Tj 0.333 Tw T* (\030\201\027\027\024\f\021\034 \023\030\024\r\036\007\036\027\027\t\n \035\ \036\004\036\027\017\036\n\), \023\036\030\036\r\024\007 \n\024\032\036\021\ )Tj 0.342 Tw T* (\002\t\021\034 \f\022\024\030\036\036 \022\024\027\006\036\023\021\031\026\ \035\034\027\t\n. \212\035\016 \027\036\024\002\b\024\007\017\n\024\f\021\ \017 )Tj 0.213 Tw T* [(\030\026\030\036\001\036\027\017\016 \r\t\016\r\035\036\027\027\t\b )0.5(\030\026\027\024\004\021\036\027\017\005 \r)]TJ /Span<>> BDC ( )Tj EMC (\021\030\026\022\021\024\r\022\026\b )Tj -0.015 Tw T* [(\023\036\030\036\r\036\007\036\027\027\024\020\024 )0.6(\021\036\022\f\021\026 )0.5(\002\t\035 )0.5(\007\024\f\021\017\020\027\031\021 )0.6(\022\024\027\f\036\027\f\031\f )0.5(\023\031\021\036\n )]TJ -0.019 Tw T* (\024\002\f\031\032\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\001\036\027\017\016 \f\023\024\030\027\t\b \n\036\f\021 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\036 \004\035\036)Tj 0 Tw (-)Tj 0.046 Tw T* (\027\026\n\017 \030\026\002\024\004\036\005 \020\030\031\023\023\t. \215\ \024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \007\026\027\027\024\020\024 \220\ \021\026\023\026 )Tj 0.068 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\210\222\200 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036 \002\t\035\017 \r\027\036\f\036\027\ \t \027\036\024\002\b\024\007\017\n\t\036 )Tj 0.165 Tw T* (\023\024\023\030\026\r\022\017. \213\f\035\017 \021\026\022\024\r\024\005\ \023\024\021\030\036\002\027\024\f\021\017 \027\036 \r\024\027\017\022\ \026\035\024, )Tj 0.084 Tw T* (\021\024 \210\222\200 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036, \f\024\007\026\027\027\026\016 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\t\007\031\013\036\n )Tj 0.113 Tw T* [(\220\021\026\023\036, )0.6(\f\004\017\021\026\035\026\f\034 )0.5(\024\022\024\027\004\026\021\036\035\034\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.619 0 Td [(\002\t\035\026 )0.5(\r\016\021\026 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 6.202 0 Td (\024\f)Tj 0 Tw (-)Tj -20.821 -1.218 Td (\027\024\r\031 \007\035\016 \022\024\020\027\017\021\017\r\027\024\020\024\ \017\027\021\036\030\r\034\033.)Tj 0.346 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \024\022\024\027\004\026\021\ \036\035\034\027\t\n \030\036\031\035\034\021\026\021\024\n \220\021\026\ \023\026 )Tj -0.011 Tw T* (\016\t\022\024\r\024\020\024 \023\036\030\036\r\024\007\026 \f\021\026\035\ \026 \f\024\007\026\027\027\026\016 \235\017\027\026\035\034\027\026\016\ \r\036\030)Tj 0 Tw (-)Tj 0.105 Tw T* [(\f\017\016 \024\023\030\024\f\027\017\022\026 PROM-HIS)17.1(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036 \(PROM-)Tj 0.152 Tw T* [(HIS)17(S_R)12(U\), \022\024\021\024\030\026\016 \017\f\023\024\035\034\024\r\026\035\026\ \f\034 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n )Tj 0 Tw T* (\220\021\026\023\036 \022\030\024\f\f-\022\031\035\034\021\031\030\027\024\ \005 \023\030\024\r\036\030\022\017.)Tj /T1_2 1 Tf 0.186 Tw 0 -2.436 TD [(\021\006\002\217\217-\220\210\f\001\003\210\006\b\004\235 )0.6(\212\006\002\r\006\220\004 )0.6(\(\004\f\t\240\004\204\t\235\) )0.5(\006\210\217\217\220\002)]TJ /Span<>> BDC (-)Tj EMC 0 Tw 0 -1.218 TD (\235\213\013\201\b\002\005 \r\006\217\t\t)Tj /T1_0 1 Tf 0.049 Tw T* (\212\026\027\027\t\005 \220\021\026\023 \r\026\035\017\007\026\006\017\017\ \r\t\023\024\035\027\036\027 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\030\024\r\036\030\022\017 )Tj -0.08 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\016\021\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\021\031 \026\007\026\r\026\036\n\t\b \r\024\023\030\ \024\f\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007)Tj 0 Tw (-)Tj 0.08 Tw T* (\035\026\020\026\036\n\t\b \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\031 \024\021\r\036\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\024\005 \r\036\030\f\017\017 )Tj 0.098 Tw T* [(\024\023\030\024\f\027\017\022\026 PROM-HIS)17.1(S_R)12(U. \221\026\022\017\n \024\002\030\026\024\n, \023\030\017\036\n\035\036\ )]TJ 0 Tw (-)Tj 0.107 Tw T* [(\n\024\f\021\034 )0.5(\007\035\016 )0.5(\006\036\035\036\r\024\005 )0.5(\023\024\023\031\035\016\006\017\017 )0.5(\023\036\030\036\r\036\007\036\027\027\024\005 )0.6(\r\036\030\f\017\017 )]TJ 0.154 Tw T* (\002\t\035\026 \023\030\024\r\036\030\036\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\036\027\026, \004\021\024 \002\t\035\024\ \027\036\024\002\b\024)Tj 0 Tw (-)Tj 0.029 Tw T* (\007\017\n\024 \007\035\016 \021\024\020\024, \004\021\024\002\t \031\002\ \036\007\017\021\034\f\016, \004\021\024 \023\030\036\007\023\024\035\026\ \020\026\036\n\t\005 )Tj 0.15 Tw T* [(\f\n\t\f\035 \024\023\030\024\f\027\017\022\026 PROM-HIS)17(S )0.5(\027\036 \002\t\035 \017\f\022\026\032\201\027 )0.5(\023\036\030\036)]TJ 0 Tw (-)Tj 0.017 Tw T* (\r\024\007\024\n. \230\027\021\036\030\r\034\033 \f)Tj /Span<>> BDC ( )Tj EMC (\026\n\002\031\035\026\021\024\030\027\t\n\017 \023\026\006\017\036\027\021\ \026\n\017, \017\n\036)Tj 0 Tw (-)Tj 0.032 Tw T* (\033\013\017\n\017 \030\026\035\017\004\027\t\036 \f\021\036\023\036\027\ \034 \021\016\032\036\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\016 \020\036)Tj 0 Tw (-)Tj -0.047 Tw T* (\n\024\030\030\024\017\007\026\035\034\027\024\005 \002\024\035\036\027\ \017, \023\030\024\r\024\007\017\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.253 Tw 23.244 64.543 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\006\017\023\024\n \253\022\024\020\027\017\021\017\r\027\ \024\020\024 \017\027\021\036\030\r\034\033\273, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.119 Tw 0 -1.218 TD (\024\006\036\027\017\r\026\035\024\f\034 \023\024\027\017\n\026\027\017\036\ \022\026\032\007\t\n \031\004\026\f\021\027\017\022\024\n \r\024\023\030\ \024)Tj 0 Tw (-)Tj 0.089 Tw 0 -1.218 TD (\f\024\r, \f\024\007\036\030\032\026\013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\035\026\020\026\036\n\t\b \r\026)Tj 0 Tw (-)Tj 0.09 Tw 0 -1.218 TD (\030\017\026\027\021\024\r \024\021\r\036\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\017\b. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\017 \024\023\030\024\f\027\017\022\026\ )Tj -0.014 Tw 0 -1.218 TD (\031\004\026\f\021\027\017\022\026\n \002\t\035\024 \023\030\036\007\035\ \024\032\036\027\024 \253\007\031\n\026\021\034 \r\f\035\031\b\273, \021\ \026\022 \022\026\022 )Tj 0.07 Tw 0 -1.218 TD (\220\021\024 \023\024\r\024\035\016\036\021 \007\036\035\026\021\034 \n\ \t\f\035\017\021\036\035\034\027\t\036 \023\030\024\006\036\f\f\t \002\024\ \035\036\036 )Tj 0 Tw 0 -1.218 TD (\016\r\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\016\021\027\t\n\017.)Tj /T1_2 1 Tf 0 -2.436 TD (\222\201\004\217\003\b\t\220\t \t\b\003\r\006\001\211)Tj /T1_0 1 Tf -0.013 Tw 0 -1.218 TD (\212\035\016 \022\024\020\027\017\021\017\r\027\024\020\024 \017\027\021\ \036\030\r\034\033 \023\035\026\027\017\030\024\r\026\035\024\f\034 \023\ \030\017\r\035\036\004\034 )Tj 0.122 Tw T* (\024\021 5 \007\024)Tj /Span<>> BDC ( )Tj EMC (10 \004\036\035\024\r\036\022 \f\021\026\030\001\036 18 \035\036\021, \f\ )Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027\027\t\n )Tj 0.111 Tw T* [(\007\017\026\020\027\024\024\n \020\036\n\024\030\030\024\016 I-IV \f\021\ \026\007\017\017 \(Gol)-31(igher\), \f)]TJ /Span<>> BDC ( )Tj EMC (\007\024\f\021\026)Tj 0 Tw (-)Tj 0.112 Tw T* (\021\024\004\027\t\n \023\024\027\017\n\026\027\017\036\n \022\026\022 \031\ \f\021\027\024\020\024, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\017\f\034\n\036\027\027\024\020\024 )Tj 0.071 Tw T* (\030\031\f\f\022\024\020\024 \016\t\022\026. \215\024\007\023\017\f\026\ \027\027\024\036 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\036\ \f\024)Tj 0 Tw (-)Tj 0.294 Tw T* (\020\035\026\f\017\036 \023\026\006\017\036\027\021\026 \016\r\035\016\035\ \024\f\034 \024\002\016\026\021\036\035\034\027\t\n \031\f\035\024\r\017\ \036\n )Tj 0 Tw T* (\031\004\026\f\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\034\033.)Tj 0.119 Tw T* [(\213\f\035\017 )0.5(\r\024 )0.5(\r\030\036\n\016 )0.6(\022\024\020\027\017\021\017\r\027\024\020\024 )0.5(\017\027\021\036\030\r\034\033\017\030\024\r\026\027\017\016 )0.7(\r\t)]TJ 0 Tw (-)Tj 0.26 Tw T* [(\016\r\035\016\035\017\f\034 \023\024\021\030\036\002\027\024\f\021\017 \ )0.5(\r\024 \r\027\036\f\036\027\017\017 \017\n\036\027\036\027\017\005/\007\ \024)]TJ 0 Tw (-)Tj 0.343 Tw T* (\023\024\035\027\036\027\017\005/\031\021\024\004\027\036\027\017\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (\235\017\027\026\035\034\027\031\033 \r\036\030\f\017\033 \024\023\030\024\ \f)Tj 0 Tw (-)Tj 0.081 Tw T* (\027\017\022\026, \007\026\027\027\026\016 \027\036\024\002\b\024\007\017\ \n\024\f\021\034 \024\002\f\031\032\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\004\036\005 )Tj 0.103 Tw T* (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\016\021\017\036\n \022\024\027\f\036\027\f\031\f\026 \024\ )Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 )Tj 0.277 Tw T* (\017\n\036\027\036\027\017\016. \217\036\031\035\034\021\026\021\024\n\ \024\002\f\031\032\007\036\027\017\016 \016\r\035\016\035\026\f\034 \235\ \017)Tj 0 Tw (-)Tj 0.55 Tw T* (\027\026\035\034\027\026\016 \007\024\030\026\002\024\021\026\027\027\026\ \016 \r\036\030\f\017\016 \024\023\030\024\f\027\017\022\026 PROM-)Tj 0.254 Tw T* [(HIS)17(S_R)12(U, )0.5(\022\024\021\024\030\026\016 )0.6(\007\024\035\032\027\026 )0.5(\002\t\035\026 )0.5(\002\t\021\034 )0.6(\f\024\023\024\f\021\026\r\035\036\027\026 )]TJ 0.244 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\005 \r\036\030\f\017\036\005\ \024\023\030\024\f\027\017\022\026, \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\020\035\026\f\024\r\026\027)Tj 0 Tw (-)Tj 0.141 Tw T* (\027\024\f\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \024\002\036 \r\036\030\f\017\017 \022\024\027\006\ 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v)10(alidation of\022th)11(e )]TJ 21.255 0 Td ( )Tj -25.84 -1 Td [(PRO)20(M-HIS)21(S questionnair)31.1(e for patients with h)11(emorrh)11(oidal disease)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 615.9841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 615.9841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 578.7763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 578.7763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 524.7071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tw 9 0 0 9 90.7087 730.4919 Tm [(RESUL)30(T)-10(S: )0.6(the translated )0.5(v)13(ersion, )0.6(P)66(R)19(OM-HISS_R)27(U)47(, )0.5(has )0.5(good )0.5(e)-15(xter)-13.9(nal )0.5(and )0.5(content )0.5(v)16(alidity )0.5(and )0.5(adeq)14(uately )0.5(ref)-22(lects the )]TJ -0.005 Tw 0 -1.111 TD [(haemor)-15.9(rhoids sym)16(p)13(toms, )0.5(their im)16.1(pact on q)14(uality )0.5(of life, )0.5(and treatment )0.5(satisfaction. 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Linnik are full-time em)16(plo)12(yees of)]TJ /Span<>> BDC ( )Tj EMC [(the JSC \244Ser)-41.9(vier\245)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 0.005 -1.909 Td [(A)29(CKN)21(O)15(WLEDGEMENTS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.462 0 Td ( The)Tj /Span<>> BDC ( )Tj EMC [(authors w)12(ould lik)17(e to)]TJ /Span<>> BDC ( )Tj EMC (thank the)Tj /Span<>> BDC ( )Tj EMC [(TREN)22(C)14(H INSIGHT)-9.9(S ag)12(ency for conducting cognitiv)13(e inter)-41.9(vie)10(ws)]TJ /T1_2 1 Tf 0.037 Tc 0.313 Tw -9.462 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.322 Tw 6.758 0 Td [( S)-10.3(h)-15.1(e)-18(l)-8.3(y)-17.2(g)-28.9(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)12.6(u)-9(.)-23.9(A)-23(.)-23.5(, K)-11.2(o)-15.8(s)-29.3(t)-36.8(a)-10.2(r)-19.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)40.6(V)39.7(.)-23.5(, K)12.1(v)-28.4(a)-26.6(s)-6.6(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(B)3.3(.B)3.3(.)-23.5(, L)-12.2(i)-3.2(n)-5.7(n)-14(i)-6.6(k O)11.4(.)-28.6(Z)-19.6(h)-5.1(. R)-6.7(e)-22.8(s)-8.8(u)-8.4(l)-15.4(t)-48.9(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(l)-16.7(i)-3.2(n)-11.9(g)-9.5(u)-13(i)-7.4(s)-29.3(t)-46.2(i)-5(c a)-7.6(n)-14.5(d c)-22.3(r)-15.8(o)-15.8(s)-22.2(s)-12.7(-)-28.6(c)-12.1(u)-8.4(l)-15.4(t)-22.3(u)-7.6(r)-30.8(a)-11.4(l v)-28.4(a)-11.4(l)-16.7(i)-8.8(d)-9.3(a)]TJ 0 Tc 0 Tw 49.578 0 Td (-)Tj 0.023 Tc 0.153 Tw -56.341 -1.2 Td [(t)-46.2(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e P)-1.9(R)-9.8(O)-6.5(M)-15.6(-)-12.5(H)-2.8(I)-35.5(S)-24.8(S q)-16(u)-12.5(e)-22.8(s)-29.3(t)-46.2(i)-6.8(o)-9.2(n)-5.7(n)-7.8(a)-14.9(i)-6(r)-19.1(e f)-25.2(o)-11.8(r p)-20(a)-18.2(t)-46.2(i)-10.9(e)-11.6(n)-17.3(t)-48.8(s w)-45.7(i)-15.8(t)-26.1(h h)-15.1(e)-11.5(m)-12.4(o)-11.8(r)-40.5(r)-28.4(h)-10.9(o)-12.5(i)-8.8(d)-9.3(a)-11.4(l d)-15.8(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.9(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)14(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.8(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.163 Tw 42.348 0 Td [( 2)-18.9(0)-13.8(2)-5.8(6)9.9(;2)-11.4(5)-9.1(\()27.7(1)34.3(\))4.5(:)11(1)-17.9(3)-29.3(4)-34.7(\226)40.9(1)2.5(4)30.1(1)-5.8(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.3(\).)13( )]TJ -0.032 Tc 0.032 Tw -42.348 -1.2 Td [(h)-72.2(t)-104.4(t)-84.4(p)-73.7(s)-62.9(:)-53.1(/)29.7(/)-18.6(d)-66.1(o)-67.5(i)-55.2(.)-52.3(o)-66.8(r)-71.7(g)-77.8(/)-43.7(1)-41(0)-48.5(.)-60.6(3)-47.1(3)-70.9(8)-53.7(7)-50.4(8)-55(/)-47.1(2)-63.9(0)-45.7(7)-56.9(3)-68.3(-)-13.8(7)-44.3(5)-54.6(5)-63.9(6)-81.7(-)-45.2(2)-63.9(0)-58.8(2)-50.8(6)-81.7(-)-45.3(2)-56.4(5)-78.5(-1)-28.1(-1)-62.9(3)-74.2(4)-83.5(-1)-42.4(4)-14.9(1)]TJ /T1_2 1 Tf 0.01 Tc -0.006 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc -0.001 Tw 10.529 0 Td ( \035\022\025\025\022\n \217\f\017\b\020 \234\020\025\031\021\025\020, \003\ \217 \253\205\027\032\021\017\027\273, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\035\027\024\025\020\t, \030.)Tj /Span<>> BDC ( )Tj EMC (7, \215\031\024\n\021\020, 125196, \206\031\024\024\022\t; \023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(915\) 113-51-23; e-mail: )Tj 0 Tw -10.534 -1.2 Td (olga.linnik@servier.com)Tj /T1_2 1 Tf 0.01 Tc 0.072 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.077 Tw 14.159 0 Td [( Linnik Olg)12(a Zhanovna, JSC \244Ser)-42(vier\245, Lesnaya st., 7, Moscow)52(, 125196, R)22(ussia; phone:)]TJ /Span<>> BDC ( )Tj EMC (+7 \(915\) 113-51-23; )Tj 0.023 Tw -14.164 -1.2 Td [(e-mail: olg)12(a.linnik@ser)-41.9(vier)51.1(.com.)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 20.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 20.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 469.0919 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.277 Tw 10 0 0 10 42.5197 444.7359 Tm (\206\036\n\024\030\030\024\005)Tj /Span<>> BDC ( )Tj EMC 4.504 0 Td [(\227 )0.5(\024\007\027\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.442 0 Td [(\027\026\017\002\024\035\036\036 )0.6(\030\026\f\023\030\024\f\021\030\026\027\201\027\027\t\b )]TJ 0.225 Tw -9.947 -1.218 Td (\023\030\017\004\017\027 \024\002\030\026\013\036\027\017\016 \023\026\006\ \017\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\r\030\026\004\031 \f)Tj /Span<>> BDC ( )Tj EMC (\032\026\035\024\002\026\n\017 )Tj 0.061 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \023\030\024\002\035\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\030\036\022\021\026\035\034\027\024\005 \024\002\035\026\f\021\ \017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f)Tj 0 Tw (-)Tj 0.186 Tw T* (\023\030\024\f\021\030\026\027\201\027\027\024\f\021\034\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (44% [1]. \222\017\n\023\021\024\n\t \020\036\n\024\030\030\024\016 )Tj 0.059 Tw T* (\r\022\035\033\004\026\033\021 \022\030\024\r\024\021\036\004\036\027\017\ \036, \r\t\023\026\007\036\027\017\036 \031\035\024\r, \002\024\035\034\ , \031\007, )Tj 0.08 Tw T* (\007\017\f\022\024\n\235\024\030\021. \025\026\004\036\f\021\r\036\027\027\ \t\036 \017\f\f\035\036\007\024\r\026\027\017\016 \023\024\022\026\t\r\026\ )Tj 0 Tw (-)Tj 0.15 Tw T* (\033\021, \004\021\024 \f\017\n\023\021\024\n\t \020\036\n\024\030\030\024\ \016 \024\022\026\t\r\026\033\021 \r\t\030\026\032\036\027\027\024\036 \ )Tj 0.213 Tw T* (\r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017 \023\026\006\017\036\027\021\ \024\r [1], \r\035\017\016\033\021 )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\ \024\f\021\034 [2,3].)Tj -0.01 Tc 0.512 Tw T* [(\200\026\032\027\024 )0.5(\024\021\n\036\021\017\021\034, )0.5(\004\021\024 )0.5(\023\030\036\007\f\021\026\r\035\036\027\017\016 )0.5(\023\026\006\017\036\027\021\026 )0.5(\024\002)-10( )]TJ 0.094 Tw T* (\031\f\023\036\001\027\024\f\021\017 \035\036\004\036\027\017\016 \n\024\ \020\031\021 \f\017\035\034\027\024 \024\021\035\017\004\026\021\034\f\016\ \024\021 \022\030\017)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.051 Tw T* (\021\036\030\017\036\r \031\f\023\036\001\027\024\f\021\017 \035\036\004\ \036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\024\004\022\017 \030\036\027\017\016 \r\030\026\004\026 [3].)-10( )]TJ -0.023 Tw T* (\213\r\030\024\023\036\005\f\022\024\036 \024\002\013\036\f\021\r\024 \022\ \024\035\024\023\030\024\022\021\024\035\024\020\017\017 \(ESCP\) \r)Tj /Span<>> BDC ( )Tj EMC [(2019)-9.9( )]TJ 0.324 Tw T* [(\020\024\007\031 \024\023\031\002\035\017\022\024\r\026\035\024 \024\f\027\ \024\r\027\024\005 \027\026\002\024\030 \017\f\b\024\007\024\r \(\210\203\ \230,)-10( )]TJ 0.169 Tw T* [(\026\027\020\035. C)13(OS\) \007\035\016 \020\036\n\024\030\030\024\016, \023\024\007\004\036\030\ \022\017\r\026\033\013\017\005 \r\026\032\027\024\f\021\034)-9.9( )]TJ 0.077 Tw T* (\031\004\201\021\026 \n\027\036\027\017\016 \023\026\006\017\036\027\021\ \026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\f\036\007\027\036\r\027\024\005 \023\030\026\022\021\017\022\036\ ,)-10( )]TJ 0.075 Tw T* [(\021\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.377 0 Td [(\r )0.5(\027\026\031\004\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.5([4]. )0.5(\210\f\027\024\r\027\t\n\017 )0.5(\017\f\b\024)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc 0.086 Tw -2.377 -1.218 Td [(\007\026\n\017, \023\030\036\007\f\021\026\r\035\016\033\013\017\n\017 \017\ \027\021\036\030\036\f \007\035\016 \024\006\036\027\022\017 \r\035\017\016\ \027\017\016)-10( )]TJ -0.059 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \021\024\005 \017\035\017 \017\027\024\005 \f\021\030\026\021\ \036\020\017\017 \035\036\004\036\027\017\016, \016\r\035\016\033\021\f\016\ \f\017\n\023)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc -0.032 Tw T* (\021\024\n\t \020\036\n\024\030\030\024\016, \026)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\n)Tj /Span<>> BDC ( )Tj EMC (\227 \031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\034 \035\ \036)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.061 Tw T* (\004\036\027\017\036\n. \233\021\017 \017\f\b\024\007\t \035\031\004\001\ \036 \r\f\036\020\024 \017\n\036\030\016\021\034 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033)-10( )]TJ 0.138 Tw T* [(\023\024\022\026\026\021\036\035\036\005, \f\024\024\002\013\026\036\n\t\ \b \f\026\n\017\n \023\026\006\017\036\027\021\024\n \(p)32(a)15.1(t)-32(ient-)]TJ -0.039 Tw T* [(r)-24(epor)-21.9(ted outcome measur)-23.9(e, PROM\), \022\024\021\024\030\t\036 \f\024\002\017\030\026\033\021\f\016\ )-10( )]TJ 0.057 Tw T* [(\027\026\023\030\016\n\031\033 \024\021 \023\026\006\017\036\027\021\026\ \002\036 \017\027\021\036\030\023\030\036\021\026\006\017\017 \f\024 \f\ \021\024\030\024\027\t)-10( )]TJ 0 Tw T* (\n\036\007\017\006\017\027\f\022\017\b \030\026\002\024\021\027\017\022\024\ \r \017\035\017 \007\030\031\020\017\b \035\017\006 [5].)Tj 0 Tc 0.127 Tw T* (\203\036\007\026\r\027\024 \002\t\035 \030\026\030\026\002\024\021\026\027\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\035\017\007\017\030\024\r\026\027 PROM, \f\023\036)Tj 0 Tw (-)Tj 0.227 Tw T* (\006\017\026\035\034\027\024 \023\030\036\007\027\026\027\026\004\036\027\ \027\t\005 \007\035\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030)Tj 0 Tw (-)Tj 0.03 Tw T* (\030\024\036\n)Tj /Span<>> BDC ( )Tj EMC (\227 \001\022\026\035\026 \024\006\036\027\022\017 \f\021\036\023\036\027\ \017 \r\035\017\016\027\017\016 \026\002\024\035\036\r\026\027\017\016 \ )Tj 0.282 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\024\f\021\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\017 )Tj 0.256 Tw T* [(\035\036\004\036\027\017\036\n \(PROM-HIS)17(S\) [6]. PROM-HIS)17(S \002\t\035 \f\024\007\026\027 )]TJ 0.379 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \017\027\021\036\030\r\034\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017, \f\021\030\026\007\026\033\013\017\ \n\017 )Tj 0.131 Tw 23.244 38.97 Td (\020\036\n\024\030\030\024\036\n, \026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\026\030\026\002\024\021\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\f\021\017\030\024\r\026\027\017\036 \f\021\030\024\020\024 )Tj -0.031 Tw T* [(\f\024\024\021\r\036\021\f\021\r\024\r\026\035\017 \030\036\022\024\n\036\ \027\007\026\006\017\016\n C)13(OSMIN [3,7]. PROM-)]TJ 0.179 Tw T* [(HIS)17(S )0.5(\023\030\017\027\026\027 )0.6(\r\026\035\017\007\027\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.614 0 Td [(\027\026\007\201\032\027\t\n )0.5(\017\027\f\021\030\031\n\036\027\021\024\n )]TJ 0.235 Tw -11.614 -1.218 Td (\007\035\016 \024\006\036\027\022\017 \f\017\n\023\021\024\n\024\r \020\036\ \n\024\030\030\024\016, \r\035\017\016\027\017\016 \002\024\035\036\027\ \017 )Tj 0.302 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\024\f\021\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\034 )Tj 0 Tw T* (\023\026\006\017\036\027\021\026 \035\036\004\036\027\017\036\n [6].)Tj -0.002 Tc -0.071 Tw T* [(\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 PROM-HIS)17(S \007\024\f\021\031\023\036\027 \021\024\035\034\022\024 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\020\024\035)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.107 Tw T* (\035\026\027\007\f\022\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n \016\t\022\026\b [6,8]. \232\021\024\ \002\t \024\002\036\f\023\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.2 Tw T* [(\004\017\021\034 \001\017\030\024\022\024\036 \020\036\024\020\030\026\235\ \017\004\036\f\022\024\036 \023\030\017\n\036\027\036\027\017\036 \007\026\ \027\027\024\020\024)-2( )]TJ 0.377 Tw T* [(\017\027\f\021\030\031\n\036\027\021\026, \f\035\036\007\031\033\013\017\ \n \001\026\020\024\n \016\r\035\016\036\021\f\016 \023\036\030\036\r\024\ \007)-2( )]TJ 0.167 Tw T* [(PROM-HIS)17(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 \016\t\022\017 \n\017\030\026. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.199 Tw T* [(\007\024\r\026\027\017\017 \024\023\017\f\t\r\026\036\021\f\016 \023\030\ \024\006\036\f\f \023\036\030\036\r\024\007\026 PROM-HIS)17(S)-2( )]TJ 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \016\t\022 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005 \r\ \026\035\017\007\026\006\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 286.4219 Tm [(\207\034)-31(\024)35(\037\230\037\r\037\021\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf -0.012 Tc 0.021 Tw 10 0 0 10 274.9606 262.0659 Tm (\212\017\026\005\027 \007\026\027\027\024\020\024 \017\f\f\035\036\007\024\ \r\026\027\017\016 \f\024\f\021\024\016\035 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\r\031\b \004\026\f\021\036\005:)-12( )]TJ -0.052 Tw T* [(1\) \016\t\022\024\r\024\005 \023\036\030\036\r\024\007 PROM-HIS)17(S \f)]TJ /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.071 Tw T* (\f\022\017\005 \016\t\022; \017)Tj /Span<>> BDC ( )Tj EMC (2\) \022\030\024\f\f-\022\031\035\034\021\031\030\027\026\016 \r\026\035\ \017\007\026\006\017\016 \030\031\f\f\022\024\016)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.171 Tw T* [(\t\004\027\024\005 \r\036\030\f\017\017 PROM-HIS)17(S \r)]TJ /Span<>> BDC ( )Tj EMC [(\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017.\ )-12( )]TJ 0.192 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \023\036\030\036\r\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005 \r\026\035\017\ \007\026\006\017\017)-12( )]TJ 0.141 Tw T* (\002\t\035\017 \f\024\002\035\033\007\036\027\t \024\235\017\006\017\026\ \035\034\027\t\036 \030\036\022\024\n\036\027\007\026\006\017\017 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\023\036)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.393 Tw T* [(\030\036\r\024\007\031 \017\f\b\024\007\024\r, \f\024\024\002\013\026\036\ \n\t\b \023\026\006\017\036\027\021\026\n\017 \(P)40(a)15(t)-32(ient-)]TJ -0.03 Tw T* [(R)13(epor)-21.9(ted )0.5(Outcomes )0.5(Measur)-23.9(es )0.5(\017\035\017 )0.5(PROM\). )0.6(\230\f\023\024\035\034\024\r\026\027\t)-12( )]TJ 0.151 Tw T* [(\030\031\022\024\r\024\007\016\013\017\036 \023\030\017\027\006\017\023\t\ \027\026\007\035\036\032\026\013\036\005 \023\030\026\022\021\017\022\017\ ISPOR)-12( )]TJ 0 Tw T* ([9] \007\035\016 \022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005\ \023\030\024\r\036\030\022\017 PROM.)Tj /T1_5 1 Tf 0 Tc 0 -2.436 TD (\223\213\013\220\002\002\005 \212\r\006\r\002\240)Tj /T1_3 1 Tf 0.281 Tw 0 -1.218 TD (\215\030\016\n\024\005 \023\036\030\036\r\024\007 \023\030\024\017\r\024\ \007\017\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\024\020\024 \016\t\022\026 )Tj 0.035 Tw T* (\(\020\024\035\035\026\027\007\f\022\024\020\024\) \027\026)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\r\024\005 \016\t\022 \(\030\031\f\f\022\017\005\) \007\ \r\031\n\016 \027\036)Tj 0 Tw (-)Tj 0.254 Tw T* (\026\r\017\f\017\n\t\n\017 \027\024\f\017\021\036\035\016\n\017 \030\031\ \f\f\022\024\020\024 \016\t\022\026, \f\r\024\002\024\007\027\024 )Tj 0 Tw T* (\020\024\r\024\030\016\013\017\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 505.4271 56.0378 Tm (135)Tj ET endstream endobj 709 0 obj [713 0 R] endobj 710 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 325.5411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 325.5411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 288.3333 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 288.3333 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-134-141)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 90.3587 695.3259 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \213\212\217\r)10(\025\b\025\221 \n\022)-23.2(\r\005\025\016\016-\r\002\020\200)21(\026)-19.9(\002\005\t\025\221 \b\017\020\n\202\017\n\n )]TJ 0.228 -1.105 Td [(\025\224\005\025\016\t\n\r\017 PRO)20.1(M-HIS)21(S \202)-21(\020\213 \224\017\n\004\t\026)11(\025\b \016\022)-23.3(\013)10(\004\024\025\005\005\025\004\024)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 649.822 Tm [(\222\004\020\217\013\n\t\022)-23.2(\207.\f)-31(.)]TJ 8.162 0 0 8.162 158.3548 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 162.9908 649.822 Tm [(, \037)31(\025\016)-10(\026)11(\017\005\004\b\022)-23.2(\030.\021.)]TJ 0 Tw 8.162 0 0 8.162 252.906 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 257.5419 649.822 Tm [(, \037)20(\b\017\016\t\n\r)10(\025\b\022)-23.2(\006.\006.)]TJ 0 Tw 8.162 0 0 8.162 352.1047 654.484 Tm (2)Tj 0.023 Tw 14 0 0 14 356.7407 649.822 Tm [(, \035\n\t\t\n\r\022)-23.2(\036.\223.)]TJ 0 Tw 8.162 0 0 8.162 441.7556 654.484 Tm (2)Tj 5.83 0 0 5.83 70.8661 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 632.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 608.1527 Tm [(\f\036 \253\001\004\005\b\200\004\273 \(\002\020.\022)-23.3(\035\004\016\t\017\213 \202.\022)-23.3(7)127(, \235\025\016\r\b\017, 1)125(2)23(5)127(1)138(9)23(6, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.086 Tw 9 0 0 9 119.0551 589.6488 Tm [(\216\027\026\031\032\032\031\235 )0.6(\t\021\f\t\027\023\024\t )0.6(\031\030\025\022\026 )0.6(\022\016)]TJ /Span<>> BDC ( )Tj EMC 12.524 0 Td [(\025\020\022\240\031\f\027\027 )0.6(\032\020\024\033\032\031\024\023\032\020\025\027\025\025\013\200 )0.7(\016\020\240\031\f\027\021\020\025\022\235 )0.5(\020\025\031\032\027\n\023\020\f\017\025\031\235 )0.6(\031\240\f\020\024\023\022, )0.5(\025\027\b\020\023\022\021)]TJ 0 Tw (-)Tj 0.151 Tw -12.524 -1.111 Td (\025\031 \021\f\022\t\005\212\022\200 \025\020)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\031 \255\022\016\025\022 \033\020\006\022\027\ \025\023\031\021. PROM-HISS)Tj /Span<>> BDC ( )Tj EMC (\227 \024\031\021\032\027\026\027\025\025\013\235 \031\033\032\031\024\025\ \022\n, \024\031\016\030\020\025\025\013\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\027 )Tj 0.078 Tw 0 -1.111 TD (\032\027\n\031\026\027\025\030\020\006\022\235 COSMIN \(Consensus-based \ Standards for the)Tj /Span<>> BDC ( )Tj EMC (selection of)Tj /Span<>> BDC ( )Tj EMC (health status Measurement Instruments\) )Tj 0.117 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\021\n\f\005\007\020\005\212\022\235 \031\006\027\025\n\r \024\022\026\033\ \023\031\026\031\021 \016\020\240\031\f\027\021\020\025\022\t, \021\f\022\ \t\025\022\t \b\027\026\031\032\032\031\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\024\027\030\025\027\021\025\r\005 \020\n\023\022\021\025\031\ \024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\r )Tj 0.169 Tw T* (\r\030\031\021\f\027\023\021\031\032\233\025\025\031\024\023\022 \033\032\ \031\021\027\030\027\025\025\013\026 \f\027\007\027\025\022\027\026. \217\ \033\032\031\024\025\022\n \032\020\016\032\020\240\031\023\020\025 \025\ \020)Tj /Span<>> BDC ( )Tj EMC (\b\031\f\f\020\025\030\024\n\031\026 \t\016\013\n\027 \022)Tj /Span<>> BDC ( )Tj EMC (\021\020\f\022\030\022\032\031\021\020\025 )Tj 0.023 Tw 0 -1.111 TD (\025\020)Tj /Span<>> BDC ( )Tj EMC (\020\025\b\f\022\235\024\n\022\235 \t\016\013\n.)Tj 0.25 Tw 0 -1.111 TD (\037\036\035\034: \033\032\031\021\027\024\023\022 \t\016\013\n\031\021\r\ \005 \020\030\020\033\023\020\006\022\005 \022)Tj /Span<>> BDC ( )Tj EMC (\n\032\031\024\024-\n\r\f\017\023\r\032\025\r\005 \021\020\f\022\030\020\ \006\022\005 PROM-HISS \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\r\024\024\n\022\235 \t\016\013\n \030\f\t )Tj 0.023 Tw T* (\022\024\033\031\f\017\016\031\021\020\025\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\206\214.)Tj 0.117 Tw T* (\215\036\217\220\201: \033\027\032\027\021\031\030 \031\033\032\031\024\ \025\022\n\020 \021\013\033\031\f\025\027\025 \030\021\r\026\t \025\027\016\ \020\021\022\024\022\026\013\026\022 \033\027\032\027\021\031\030\007\022\ \n\020\026\022 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\030\r\005\212\022\026 \031\240\236\027\030\022\025\027\ \025\022\027\026 )Tj -0.014 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\031\240\024\r\255\030\027\025\022\027\026 \023\027\032\026\022\025\031\f\ \031\b\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\032\020\240\031\007\027\235 \b\032\r\033\033\031\235, \021\n\f\005\007\020\ \005\212\027\235 \n\031\f\031\033\032\031\n\023\031\f\031\b\020 \022)Tj /Span<>> BDC ( )Tj EMC (\024\033\027\006\022\020\f\022\024\023\031\021 \026\027\030\022\006\022\025\ \024\n\031)Tj 0 Tw (-)Tj 0.014 Tw T* (\b\031 \033\027\032\027\021\031\030\020. \004\032\031\021\027\030\233\025\ \031\240\032\020\023\025\013\235 \033\027\032\027\021\031\030 \030\f\t \ \n\031\025\023\032\031\f\t \n\020\007\027\024\023\021\020 \022)Tj /Span<>> BDC ( )Tj EMC (\024\031\200\032\020\025\027\025\022\t \n\031\025\006\027\033\023\r\020\f\ \017\025\031\b\031 \024\031\031\023\021\027\023)Tj 0 Tw (-)Tj 0.049 Tw T* (\024\023\021\022\t \031\032\022\b\022\025\020\f\r. \211)Tj /Span<>> BDC ( )Tj EMC (\032\020\026\n\020\200 \n\032\031\024\024-\n\r\f\017\023\r\032\025\031\235\ \033\032\031\021\027\032\n\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \n\031\b\025\022\023\ \022\021\025\013\200 \022\025\023\027\032\021\017\005 \r\007\020\024\023\ \021\031)Tj 0 Tw (-)Tj 0.06 Tw T* (\021\020\f\022 10 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\025\013\026\022 \024\023\020\030\022\t\026\022 \200\032\031\ \025\022\007\027\024\n\031\b\031 \b\027\026\031\032\032\031\t \(\n\f\020\ \024\024\022\203\022\n\020\006\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (Goligher\). \217\240\024\r\255\030\020\f\022\024\017 )Tj 0.023 Tw T* (\033\031\025\t\023\025\031\024\023\017, \033\031\f\025\031\023\020 \022)Tj /Span<>> BDC ( )Tj EMC (\032\027\f\027\021\020\025\023\025\031\024\023\017 \021\031\033\032\031\024\ \031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\021\020\032\022\020\025\023\031\021 \031\023\021\027\023\031\021.)Tj 0.121 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \031\033\032\031\024\025\022\n PROM-\ HISS_RU \031\240\f\020\030\020\027\023 \200\031\032\031\213\027\235 \021\ \025\027\213\025\027\235 \022)Tj /Span<>> BDC ( )Tj EMC (\024\031\030\027\032\255\020\023\027\f\017\025\031\235 \021\020\f\022\030\ \025\031\024\023\017\005, \020\030\027\n)Tj 0 Tw (-)Tj 0.203 Tw 0 -1.111 TD [(\021\020\023\025\031 )0.5(\031\023\032\020\255\020\027\023 )0.5(\024\022\026\033\023\031\026\013 )0.6(\b\027\026\031\032\032\031\t, )0.5(\022\200 \021\f\022\t\025\022\027 )0.6(\025\020)]TJ /Span<>> BDC ( )Tj EMC [(\n\020\007\027\024\023\021\031 )0.5(\255\022\016\025\022 \022)]TJ /Span<>> BDC ( )Tj EMC 32.046 0 Td (\r\030\031\021\f\027\023\021\031\032\233\025\025\031\024\023\017 \f\027\007\ \027\025\022\027\026. )Tj 0.149 Tw -32.046 -1.111 Td (\210\007\020\024\023\025\022\n\022 \031\006\027\025\022\f\022 \031\033\032\ \031\024\025\022\n \n\020\n \033\031\025\t\023\025\013\235, \022\025\203\ \031\032\026\020\023\022\021\025\013\235 \022)Tj /Span<>> BDC ( )Tj EMC (\n\031\026\033\020\n\023\025\013\235. \211)Tj /Span<>> BDC ( )Tj EMC (\200\031\030\027 \021\020\f\022\030\020\006\022\022 \021\025\027\024\027\ \025\013 )Tj 0.023 Tw T* (\026\022\025\022\026\020\f\017\025\013\027 \t\016\013\n\031\021\013\027 \ \022)Tj /Span<>> BDC ( )Tj EMC (\023\027\032\026\022\025\031\f\031\b\022\007\027\024\n\022\027 \n\031\032\ \032\027\n\006\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\024\031\200\032\020\025\027\025\022\027\026 \024\026\013\024\f\031\021\031\ \235 \024\023\032\r\n\023\r\032\013 \031\033\032\031\024\025\022\n\020.)Tj -0.031 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.5(\031\033\032\031\024\025\022\n )0.5(PROM-HISS_RU )0.5(\t\021\f\t\027\023\024\t )0.5(\030\027\235\024\023\021\027\025\025\013\026 )0.5(\022\025\024\023\032\r\026\027\025\023\031\026 )0.5(\030\f\t \031\006\027\025\n\022 \024\022\026\033\023\031\026\031\021 \b\027\ \026\031\032)]TJ 0 Tw (-)Tj 0.023 Tw T* (\032\031\t \022)Tj /Span<>> BDC ( )Tj EMC (\027\b\031 \021\f\022\t\025\022\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\024\027\030\025\027\021\025\r\005 \030\027\t\023\027\f\017\025\ \031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\030\031\021\f\027\023\021\031\032\027\025\025\031\024\023\017 \033\020\ \006\022\027\025\023\031\021 \f\027\007\027\025\022\027\026.)Tj /T1_2 1 Tf 0.01 Tc -0.015 Tw 8 0 0 8 70.906 384.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc -0.01 Tw 8.46 0 Td ( \031\033\032\031\024\025\022\n \030\f\t \031\006\027\025\n\022 \n\020\007\ \027\024\023\021\020 \255\022\016\025\022 \022)Tj /Span<>> BDC ( )Tj EMC (\r\030\031\021\f\027\023\021\031\032\027\025\025\031\024\023\022 \f\027\007\ \027\025\022\027\026 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\b\027\026\031\032\032\031\027\026, PROM-HISS, \b\027\026\031\032\032\031\ \235)Tj /T1_2 1 Tf 0.01 Tc 0.066 Tw -8.46 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.071 Tw 10.449 0 Td ( \237\027\f\013\b\022\025 \224.\003. \016\020\t\021\f\t\027\023 \031\240\ \031\023\024\r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\ \025\023\027\032\027\024\031\021. \202\031\024\023\020\032\027\021 \002.\ \211. \024\031\031\240\212\020\027\023 \031)Tj /Span<>> BDC ( )Tj EMC (\033\031\f\r\007\027\025\022\022 \b\031\025\031)Tj 0 Tw (-)Tj 0.043 Tw -10.454 -1.2 Td [(\032\020\032\031\021 )0.5(\016\020)]TJ /Span<>> BDC ( )Tj EMC (\f\027\n\023\031\032\024\n\r\005 \022)Tj /Span<>> BDC ( )Tj EMC [(\n\031\025\024\r\f\017\023\020\023\022\021\025\r\005 \033\031\030\030\027\ \032\255\n\r )0.5(\n\031\026\033\020\025\022\022 )0.5(\253\205\027\032\021\017\027\273. )0.5(\202\021\020\024\025\022\n\031\021 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/Span<>> BDC ( )Tj EMC (\230.\200., \025\r\026\f\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\207.\207., \214\017\027\027\017\022)Tj /Span<>> BDC ( )Tj EMC (\210.\240. \217\036\031\035\034\021\026\021\t \016\t\022\024\r\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC [(\022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005 \r\026\035\017\ \007\026\006\017\017)12( )]TJ -0.011 Tc -0.063 Tw -8.961 -1.2 Td (\024\023\030\024\f\027\017\022\026 PROM-HISS \007\035\016 \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n. )Tj /T1_0 1 Tf 0.011 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.063 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (134\226141. https://doi.org/10.33878/2073-7556-2026-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (25-1-134-141)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 165.3393 262.164 Tm [(Results of\022)-23.3(linguistic and cr)20.1(oss-cultur)21(al )]TJ -1.265 -1.167 Td [(v)10(alidation of\022)-23.3(th)11(e PRO)20(M-HIS)21.1(S questionnair)31.1(e )]TJ 1.008 -1.167 Td [(for patients with h)11(emorrh)11(oidal disease)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 195.66 Tm [(Y)40(ur)-31(y\022)-23.2(A)-31(.\022)-23.3(Sh)11(ely)10(gin)]TJ 8.162 0 0 8.162 164.4486 200.322 Tm (1)Tj 0.023 Tw 14 0 0 14 169.0845 195.66 Tm [(, Iv)10(an\022)-23.3(V)62.1(.\022)-23.3(K)40.9(ostar)31.1(e)11(v)]TJ 0 Tw 8.162 0 0 8.162 267.3759 200.322 Tm (1)Tj 0.023 Tw 14 0 0 14 272.0119 195.66 Tm [(, Boris\022)-23.2(B.\022)-23.3(K)41(v)10(asnik)11(ov)]TJ 0 Tw 8.162 0 0 8.162 381.5723 200.322 Tm (2)Tj 0.023 Tw 14 0 0 14 386.2083 195.66 Tm [(, Olga\022)-23.2(Zh.\022)-23.3(Linnik)]TJ 0 Tw 8.162 0 0 8.162 480.0464 200.322 Tm (2)Tj 5.83 0 0 5.83 70.8661 181.3208 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 177.9908 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 169.3208 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 165.9908 Tm [(JSC \232Ser)-20.9(vier\233 \(Lesnay)21.1(a\022)-23.3(st., 7)127(, Moscow)22(, 1)125(2)23(5)127(1)138(9)23(6, Russia\))]TJ /T1_0 1 Tf 0.129 Tw 9 0 0 9 119.0551 147.4869 Tm [(AIM: to per)-34(for)-13.9(m languag)12(e ad)26(ap)13(tation into R)22(ussian and cross-cultural v)16(alid)26(ation of P)66(R)19.1(OM-HISS for its use in the )]TJ 0.023 Tw 0 -1.111 TD [(R)22(ussian F)11(ederation.)]TJ 0.091 Tw T* [(METHODS: the q)14(uestionnaire w)13(as translated by tw)12(o independent translators, then combined and discussed with a )]TJ 0.13 Tw T* [(w)12(orking g)14(roup including a p)46(roctologist and medical translation specialists. A back)32(-translation w)13(as conducted to )]TJ 0.055 Tw T* [(ensure q)14(uality control and concep)13(tual f)-43(idelity to the or)-36.9(iginal. T)54(en patients with v)15.9(ar)-43(ying stag)12(es of chronic haemor)]TJ 0 Tw 44.743 0 Td (-)Tj 0.149 Tw -44.743 -1.111 Td [(rhoids )0.5(\(Goligher\222)37.1(s classif)-42.9(ication\) )0.5(par)-40(ticipated )0.5(in )0.5(cross-cultural )0.5(v)16(alid)26.1(ation )0.5(using cognitiv)13(e inter)-42(vie)10(ws. The )0.5(clar)-37(ity)41.9(, )]TJ 0.023 Tw T* [(com)16(pleteness, and relev)16.1(ance of the q)14(uestions and answ)12(er op)13(tions w)12(ere discussed.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 598.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 589.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 155.9912 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 147.0639 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8402 56.0378 Tm (134)Tj ET 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[(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.936 Tw [( \205)27.6(\r)9.3(\213)7.2(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\217)27.6(.)29.3(\002)28.8(.)7.8(, \205)27.6(\r)-4.3(\032\031)9.6(\021)-0.8(\027)0.7(\b)10(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\036)22.8(.)43.7(\205)-2.1(. )]TJ -0.01 Tc 0.01 Tw 0 -1.218 TD [(\214)-2.9(\032)-9.9(\031\f)-6.6(\031\021)]TJ /Span<>> BDC 2.968 0 Td ( )Tj EMC [(\205)-12.1(.)-2.7(\003)-12.2(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -2.968 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.304 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)13(o)-0.6(v)33.6(, )]TJ 0 Tw 0 -1.218 TD [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.6(e)-3.5(g)-14.5(i)8.4(n)-6(, E)20.7(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)1.9(o)0.5(m)4.8(y)3.8(a)1.7(k)12.9(o)-0.6(v)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(I)-18.1(s)9.3(l)3.3(a)-0.8(m)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(a)-4.4(v)0.9(l)3.3(a)-4.5(e)-3.9(v)33.5(, M)5.3(a)-17(x)-26.2(i)8.4(m)]TJ /Span<>> BDC ( )Tj EMC [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)5.2(l)4.3(u)-1.6(d)-1(o)-0.6(v)33.6(, Y)33.7(u)2.9(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(E)19.6(l)10.4(\243)9(m)-1.1(o)-0.6(v)10.8(a)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-13.9(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 9.088 0 Td [( A)9.6(i)9.4(r)7.7(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.3(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(n)3.8(ga)-4.5(z)12.4(o)-0.6(v)33.7(,)]TJ /T1_1 1 Tf -0.128 Tw -9.088 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf [( I)-18.1(s)9.3(l)3.3(a)-0.8(m)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(a)-4.4(v)0.9(l)3.3(a)-4.5(e)-4(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.6(e)-3.5(g)-14.5(i)8.4(n)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.708 Tw 3.238 0 Td [( O)-7.4(l)4.9(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.7(h)7.4(k)13(o)-0.6(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.7(e)-3.6(g)-14.4(i)8.4(n)-6(, )]TJ -0.002 Tc 0.002 Tw -3.238 -1.218 Td [(S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC [(A)-14.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(F)32.1(ro)-3.1(l)0.9(o)-2.5(v)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.646 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\231\026\r\035\026\036\r \230.\217.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0000-7500-6245)Tj 23.244 19.485 Td (\222\031\030\024\r\036\020\017\027 \213.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-5743-1344)Tj T* (\205\030\024\035\024\r \222.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4697-2839)Tj T* (\204\017\027\020\026\024\r \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj T* (\207\035\031\007\024\r \204.\210.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0001-0816-2560)Tj T* (\213\035\235\017\n\024\r\026 \224.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0007-3316-7041)Tj T* (\216\024\n\016\022\024\r \213.\202)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0005-4677-1841)Tj 0 -1.218 TD (\222\031\001\022\024\r \210.\230.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Isl)-16(am R. S)-15.9(havl)-16(aev)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0000-7500-6245)Tj T* [(Ev)-21(geni)-16(i S. Sur)-31.9(ovegin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5743-1344)Tj T* [(Ser)-32(ge)-11(y A. F)10.1(r)-32(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4697-2839)Tj 0 -1.218 TD [(Air)-33(a)15(t F. Minga)-23.9(zov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj 0 -1.218 TD [(Maxim O. Bl)35.1(ud)-16(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0001-0816-2560)Tj 0 -1.218 TD [(Y)35(ul)-31(ia A. El\225mov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3316-7041)Tj T* [(Ev)-21(geniy A. Khomy)22.1(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-4677-1841)Tj T* (Oleg I. Sushkov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 493.4479 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.072 Tw 8 0 0 8 42.5197 480.6132 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mehme)-12(t )0.5(A)15(yhan )0.5(K)25(uzu. )0.6(S)15(t)15(and)42(ar)-24(dizing )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 16.33 0 Td [(Def)-28(ini)-24(t)-31.9(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.573 0 Td [(Ea)-17(ch )0.5(Col)30(on )]TJ 0.14 Tw -23.199 -1.25 Td [(Cancer Segment: Delphi Consensus on Cl)-31(inical Dec)-24(ision-Mak)-15.9(ing for )]TJ 0.095 Tw 0 -1.25 TD [(Oncol)30(o)-16(gic Outcomes. )]TJ /T1_2 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf [( 2025 Ap)25(r 11. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (DCR.0000000000003739)Tj 0 0 0 1 k /GS1 gs 0.096 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(anak)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(S, Ma)15(tsud)42(a)]TJ /Span<>> BDC ( )Tj EMC [(A, Y)50(amad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Segment)15.1(al or R)-24(ight Hemi-)]TJ 0.282 Tw -1.296 -1.25 Td [(Colec)-16(t)17(omy? )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 7.002 0 Td [(Opt)-32(imal )0.6(Sur)-32(gical )0.6(P)35(r)-32(o)-16(cedur)-23.9(e )0.5(for )0.6(T)50(r)-33(ansver)-10(se )0.6(Col)30(on )]TJ 0.006 Tc 0.349 Tw -7.002 -1.25 Td (Cancer: A)Tj /Span<>> BDC ( )Tj EMC [(P)35.2(r)-31.8(opensi)-23.8(t)-9.8(y S)-23.8(cor)-23.8(e-Ma)15.2(tched, Mul)56.2(t)-31.9(icenter, R)13.1(e)-11.8(tr)-31.8(ospec)-15.8(t)-31.8(i)-15.8(ve)6( )]TJ 0 Tc 0 Tw T* [(S)15(tud)17(y. )]TJ /T1_2 1 Tf 0.171 Tw 2.946 0 Td [(Int J )0.5(Colorectal )0.5(Dis.)]TJ /T1_1 1 Tf [( )0.5(2023;38:58. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-023-)Tj -2.946 -1.25 Td (04360-6)Tj 0 0 0 1 k /GS1 gs 0.286 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hyeong-Min )0.5(P)40(ar)-24(k. Distr)-36.9(ibut)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)35(ym)10(ph )0.5(node me)-12(t)15(ast)15(asis )0.5(and )]TJ 0.339 Tw -1.296 -1.25 Td [(oncol)30(o)-16(gical outcomes of)]TJ /Span<>> BDC ( )Tj EMC [(mid-tr)-33(ansver)-9.9(se col)30(on cancer: e)-18(xtended )]TJ 0.138 Tw T* [(ver)-10(sus tr)-33(ansver)-9.9(se colec)-15.9(t)17(omy. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf [( 2021 A)10(ug;23\(8\):2007\226)]TJ 0.023 Tw T* [(2013. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.15659)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2021 Ap)25.1(r 17.)]TJ 0.009 Tc 0.353 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.324 0 Td (\025\035\017\027\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\007\ \026\006\017\017. \003\035\024\022\026\004\036\f\021\r\036\027\027\t\036\ \027\024\r\024\024\002\030\026\024)Tj 0 Tc 0 Tw (-)Tj 0.268 Tw -1.324 -1.25 Td (\r\026\027\017\016 \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\f\017\020\n\024\017\007\027\024\020\024 \024\021\007\ \036\035\026. \212\024\f\021\031\023\027\024 )Tj 0.003 Tc 0.349 Tw T* [(\023\024: ht)-29.7(tps://cr.minzdr)-32.7(av.gov.r)-21.6(u/p)25.3(r)-23.6(ev)-15.7(iew-cr/396_4. \222\f\t\035\022\026 \026\022\021\017\r)]TJ 0 Tc 0 Tw (-)Tj 0.001 Tc 0.35 Tw T* (\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(01.07.2025 / Cl)-31.3(inical R)12.7(ecommend)41.7(a)14.7(t)-32.3(ions. Mal)-31.2(ignant neo)]TJ 0 Tc 0 Tw (-)Tj 0.169 Tw T* [(pl)-16(as)26(ms of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(on and r)-24(ec)-16(t)17(osigmoid sec)-15.9(t)-32(ion. A)15.1(v)-15(ail)-16(able: ht)-30(tps://)]TJ 0.028 Tw T* [(cr.minzdr)-32.9(av.gov.r)-21.9(u/p)25(r)-24(ev)-16(iew-cr/396_4. )0.6(L)-31.9(ink )0.5(a)-17(c)-16(t)-31.9(i)-16(ve )0.6(as )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 22.75 0 Td (01.07.2025. )Tj 0.023 Tw -22.75 -1.25 Td (\(in Russ.\).)Tj 0.06 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(v)-15(an R)11(ongen)]TJ /Span<>> BDC ( )Tj EMC (I, Dambuis)Tj /Span<>> BDC ( )Tj EMC [(RA, v)-15(an der Hoeven)]TJ /Span<>> BDC ( )Tj EMC [(J)15.1(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison )]TJ 0.038 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(E)35(xtended Hemicolec)-16(t)17.1(omy V)30(er)-9.9(sus T)49.9(r)-32.9(ansver)-10(se Colec)-16(t)17.1(omy in P)40(a)15(t)-32(ients )]TJ -0.056 Tw T* [(wi)-24(t)-12.9(h Cancer of)]TJ /Span<>> BDC ( )Tj EMC 5.83 0 Td [(t)-13(he )0.5(T)49.9(r)-32.9(ansver)-10(se )0.5(Col)30(on. )]TJ /T1_2 1 Tf [(Acta )0.5(Chir Belg.)]TJ /T1_1 1 Tf ( 2013;113\(2\):107\226)Tj 0.023 Tw -5.83 -1.25 Td [(111. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/00015458.2013.11680794)Tj 0 0 0 1 k /GS1 gs 0.279 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Guan)Tj /Span<>> BDC ( )Tj EMC (X, Zhao)Tj /Span<>> BDC ( )Tj EMC [(Z, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Whe)-12(t)-12.9(her P)40(ar)-22(t)-32(ial Colec)-16(t)17.1(omy is )]TJ 0.001 Tw -1.296 -1.25 Td [(Oncol)30(o)-16(gicall)35.1(y Safe for )0.5(P)40(a)15(t)-32(ients )0.5(wi)-24(t)-13(h )0.5(T)50(r)-33(ansver)-10(se )0.5(Col)30(on Cancer: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ar)-31.9(ge )]TJ 0.012 Tc 0.436 Tw T* [(P)10.2(opul)-15.8(a)15.2(t)-31.8(ion-Based S)15.2(tud)17.2(y. )]TJ /T1_2 1 Tf -0.012 Tw [(Onco)13.2(targ)12.2(et)]TJ /T1_1 1 Tf 0.436 Tw [(. 2017;8\(54\):93236\22693244.)12( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.18632/onco)17(t)15(ar)-32(ge)-11.9(t.21275)]TJ 0 0 0 1 k /GS1 gs 0.187 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mil)30(one)]TJ /Span<>> BDC ( )Tj EMC [(M, Degiul)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(M, All)-15.9(aix)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mid-tr)-32.9(ansver)-9.9(se col)30(on can)]TJ 0 Tw (-)Tj 0.007 Tc 0.35 Tw -1.296 -1.25 Td [(cer and e)-18.4(xtended ver)-10.4(sus tr)-33.4(ansver)-10.3(se colec)-16.4(t)16.6(omy: R)12.5(esul)55.6(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.4(he)7( )]TJ 0.006 Tc 0.349 Tw T* [(I)0.5(t)15.6(a)0.5(l)-30.5(i)0.6(a)0.5(n)0.5( s)0.5(o)-15.5(c)-23.4(i)0.5(e)-11.5(t)-9.4(y)0.5( o)0.5(f)]TJ /Span<>> BDC 7.734 0 Td ( )Tj EMC [(s)0.5(u)0.5(r)-31.4(g)0.5(i)0.5(c)0.5(a)0.6(l)0.5( o)0.6(n)0.5(c)0.5(o)0.5(l)30.6(o)-15.5(g)16.5(y)0.6( c)0.5(o)0.5(l)30.6(o)0.5(r)-23.4(e)0.5(c)-15.5(t)15.5(a)0.6(l)0.5( c)0.5(a)0.5(n)0.5(c)0.6(e)0.5(r)0.5( n)0.5(e)-11.5(t)-31.4(w)-13.5(o)0.5(r)-23.4(k)6( )]TJ 0 Tc 0.114 Tw 21.321 37.5 Td [(\(SIC)13(O CCN\) mul)56.1(t)-32(icenter coll)-16(abor)-33(a)15(t)-32(i)-15.9(ve stud)17(y. )]TJ /T1_2 1 Tf (Eur J Surg Oncol.)Tj /T1_1 1 Tf ( 2020 )Tj 0.161 Tw T* [(Sep;46\(9\):1683\2261688. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso.2020.01.006)Tj 0 0 0 1 k /GS1 gs 0.161 Tw ( Epub 2020 )Tj 0.023 Tw T* (Mar 19. PMID: 32220542.)Tj 0.037 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(or)-33(ar)-32.9(asu)]TJ /Span<>> BDC ( )Tj EMC [(S, Cl)-16(ancy)]TJ /Span<>> BDC ( )Tj EMC [(C, Cr)-32(onin)]TJ /Span<>> BDC ( )Tj EMC [(CT, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Segment)15(al ver)-9.9(sus E)35(xtended )]TJ 0.008 Tc 0.35 Tw -1.296 -1.25 Td [(Colec)-16.2(t)16.7(omy for T)59.8(umour)-10.3(s of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.3(he T)49.8(r)-33.3(ansver)-10.2(se Col)29.7(on: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-13.2(stema)14.8(t)-32.3(ic)8( )]TJ 0.009 Tc 0.349 Tw T* [(R)13.3(ev)-15.6(iew and Me)-11.7(t)15.3(a-Anal)35.3(y)-12.7(sis. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf [( 2021;23\(3\):625\226634.)9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.15403)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.38 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td [(Ar)-33.2(asar)-33.1(adnam)]TJ /Span<>> BDC ( )Tj EMC [(RP, Br)-32.2(o)-14.2(wn)]TJ /Span<>> BDC ( )Tj EMC [(S, F)9.8(or)-24.1(bes)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Guidel)-31.2(ines for)10( )]TJ 0 Tc 0.25 Tw -1.327 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(invest)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(chr)-32(onic diar)-23.9(r)-24(hoea in adul)56(ts. Br)-36.9(i)-24(t)-32(ish S)-16(o)-16(c)-23.9(ie)-12(t)-10(y )]TJ 0.016 Tc 0.576 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-31.8(oenter)-31.8(ol)30.2(o)-15.7(g)16.2(y. 3r)-23.8(d edi)-23.8(t)-31.7(ion. )]TJ /T1_2 1 Tf -0.016 Tw (Gut)Tj /T1_1 1 Tf 0.576 Tw [(. 2018;67:1380\2261399.)16( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/gutjnl-2017-315909)Tj 0 0 0 1 k /GS1 gs 0.223 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(D, Demar)-21.9(t)-32(ines)]TJ /Span<>> BDC ( )Tj EMC [(N, Cl)-16(av)-16(ien)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A. Cl)-16(assif)-28(ica)15(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical )]TJ 0.102 Tw -1.796 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ions: a)]TJ /Span<>> BDC ( )Tj EMC [(new p)25(r)-32(oposal wi)-24(t)-12.9(h ev)-15(al)35(ua)15(t)-32(ion in a)]TJ /Span<>> BDC ( )Tj EMC [(cohor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC (6336 )Tj 0.169 Tw T* [(p)32(a)15(t)-32(ients and r)-23.9(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(sur)-32(ve)-11(y. )]TJ /T1_2 1 Tf (Ann Surg.)Tj /T1_1 1 Tf ( 2004;240\(2\):205\226213. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1097/01.sl)-15.9(a.0000133083.54934.ae)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.464 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.846 0 Td [(\200\f\036\n)0.5(\017\030\027\026\016 \024\030\020\026\027)0.5(\017\026\006\017)0.5(\016 \007\030\026\r\024\024\b)0.5(\030\026\027\036\027\017)0.5(\016. \212\017\026\030\036\016)0.5( [\006)0.5(\017\021.)13( )]TJ 0 Tc 0.088 Tw -1.846 -1.25 Td [(2024 \n\026\030\021 07]. \230\027\235\024\030\n\026\006\017\024\027\027\t\ \005 \002\033\035\035\036\021\036\027\034; 2025. [W)20(or)-30(ld Heal)56.1(t)-13(h )]TJ 0.063 Tw T* [(Or)-32(ganiza)15(t)-31.9(ion. )0.5(Diar)-23.9(r)-24(hea )0.5([c)-23.9(i)-24(t)15(a)15(t)-32(ion )0.6(2024 )0.5(Mar)-32(ch )0.6(07]. )0.6(Newsle)-12(t)-30(ter; )0.6(2025. )]TJ 0.014 Tc 0.506 Tw T* [(\212\024\f\021\031\023\027\024 \023\024: ht)-29.8(tps://www.who.int/r)-21.8(u/news-r)-31.8(o)-15.8(om/f)16.3(a)-16.8(c)-15.8(t-shee)-11.8(ts/)]TJ 0 Tc 0.299 Tw T* [(de)-12(t)15(ail/diar)-23.9(r)-24(hoeal-disease. \222\f\t\035\022\026 \026\022\021\017\r\027\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC [(01.07.2025/ W)20(or)-30(ld )]TJ -0.01 Tw T* [(Heal)56(t)-12.9(h Or)-32(ganiza)15.1(t)-32(ion. Diar)-24(r)-24(hea [c)-23.9(i)-24(ted 2024 Mar 07]. F)20(a)-17(c)-16(t shee)-12(t; 2025. )]TJ 0.002 Tc 0.349 Tw T* [(A)15.6(v)-14.5(a)0.6(i)0.6(l)-15.5(a)0.6(b)0.5(l)0.6(e)0.5(:)0.6( h)0.5(t)-29.4(t)0.6(p)0.5(s)0.6(:)0.5(/)0.6(/)0.5(w)0.6(w)0.6(w)0.5(.)0.6(w)0.5(h)0.6(o)0.5(.)0.6(i)0.6(n)0.5(t)0.6(/)0.5(r)-21.4(u)0.6(/)0.5(n)0.6(e)0.5(w)0.6(s)0.6(-)0.5(r)-31.4(o)-15.5(o)0.6(m)0.5(/)0.6(f)16.5(a)-16.4(c)-15.4(t)0.5(-)0.6(s)0.5(h)0.6(e)0.6(e)-11.5(t)0.6(s)0.5(/)0.6(d)0.5(e)-11.4(t)15.6(a)0.5(i)0.6(l)0.5(/)]TJ 0 Tc 0.023 Tw T* [(diar)-24(r)-23.9(hoeal-disease. 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R)13.2(esul)56.2(ts of)]TJ /Span<>> BDC ( )Tj EMC [(enhanced r)-23.8(ecover)-23.8(y af)-27.8(ter sur)-31.8(ger)-23.8(y \(ERA)35.2(S\) in)11( )]TJ -0.011 Tw T* [(\fol)29.8(op)24.8(r)-32.2(o)-16.1(c)-16.2(t)16.8(ol)29.8(o)-16.2(g)15.8(y. )]TJ /T1_2 1 Tf 7.091 0 Td [(K)17.8(olop)45.8(roktologia)]TJ /T1_1 1 Tf 0.416 Tw [(. )0.5(2018;2\(64\):32\22638. )0.6(\(in )0.5(Russ.\).)11( )]TJ 0 Tc 0 Tw -7.091 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2018-0-2-32-38)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.4645 56.0378 Tm (133)Tj ET endstream endobj 716 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 467.909 263.622 458.453]/Subtype/Link/Type/Annot>> endobj 717 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 457.909 121.288 448.613]/Subtype/Link/Type/Annot>> endobj 718 0 obj <>/Border[0 0 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(\024\002\027\026\030\031\032\036\027\027\024\005 \027\036\024\007\027\024\ \030\024\007\027\024\f\021\017 \020\030\031\023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \023\030\017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.198 Tw 0 -1.218 TD [(\027\026\022\024\r )0.6(\002\t\035 )0.5(\023\030\024\r\036\007\036\027 )0.5(\030\036\020\030\036\f\f\017\024\027\027\t\005 )0.5(\026\027\026\035\017. )0.5(\210\027)24( )]TJ 0.022 Tw T* (\023\024\022\026\026\035, \004\021\024 \024\002\255\036\n \024\023\036\030\ \026\006\017\017 \027\036 \016\r\035\016\035\f\016 \f\021\026\021\017\f\021\ \017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.115 Tw T* [(\004\036\f\022\017 \027\026\004\017\n\t\n \235\026\022\021\024\030\024\n\ \030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\005.)24( )]TJ 0.185 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016 \022\035\033\004\036\r\t\n\017 \023\030\ \036\007\017\022\021\024\030\026\n\017, \027\026\004\017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc -0.011 Tw T* (\021\036\035\034\027\024 \031\r\036\035\017\004\017\r\026\033\013\017\n\017\ \r\036\030\024\016\021\027\024\f\021\034 \030\026\r\017\021\017\016 \024\ \f)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.115 Tw 0 -1.218 TD (\035\024\032\027\036\027\017\005, \f\021\026\035\017 \235\024\030\n\017\030\ \024\r\026\027\017\036 \026\027\026\f\021\024\n\024\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc -0.011 Tw 0 -1.218 TD (\n\024\013\034\033 \f\001\017\r\026\033\013\017\b \026\023\023\026\030\026\ \021\024\r \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(9,48; 95% \212\230:)24( )]TJ -0.024 Tw 0 -1.218 TD (1,88\22657,66; )Tj /T1_1 1 Tf 0 Tc 0 Tw 5.3 0 Td (p)Tj /T1_0 1 Tf 0.024 Tc 0.042 Tw /Span<>> BDC 0.502 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\005 pN2 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3,63;)24( )]TJ 0.138 Tw -5.802 -1.218 Td (95% \212\230: 1,11\22612,34; )Tj /T1_1 1 Tf 0 Tc 0 Tw (p)Tj /T1_0 1 Tf 0.024 Tc 0.138 Tw /Span<>> BDC 10.109 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,01\). \200\024\030\026\f\021 \023\026\006\017\036\027\021\026)24( )]TJ 0.029 Tw -10.109 -1.218 Td (\021\026\022 \032\036 \002\t\035 \r\026\032\027\t\n \235\026\022\021\024\ \030\024\n, \023\024\r\t\001\026\033\013\017\n \r\036\030\024)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.183 Tw T* (\016\021\027\024\f\021\034 \030\026\r\017\021\017\016 \024\f\035\024\032\ \027\036\027\017\005, \024\007\027\026\022\024 \036\020\024 \f\021\026\021\ \017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.201 Tw T* (\f\021\017\004\036\f\022\026\016 \027\026\004\017\n\024\f\021\034 \017\n\ \036\035\026 \023\024\020\030\026\027\017\004\027\024\036 \027\026\004\036\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc -0.047 Tw T* (\027\017\036 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,06; 95% \212\230: 1,00\2261,14; )Tj /T1_1 1 Tf 0 Tc 0 Tw (p)Tj /T1_0 1 Tf 0.024 Tc -0.047 Tw /Span<>> BDC 15.891 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,07\). \221\026\022\017\n)24( )]TJ 0.018 Tw -15.891 -1.218 Td [(\024\002\030\026\024\n, \002\t\035\024 )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.5(\004\021\024 )0.6(\027\026\002\035\033\007\026\036\n\026\016 )0.6(\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.024 Tc 0.039 Tw T* [(\027\017\006\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.185 0 Td [(\004\026\f\021\024\021\036 )0.5(\030\026\r\017\021\017\016 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.5(\024\002\031\f\035\024\r\035\036\027\026)24( )]TJ 0.055 Tw -3.185 -1.218 Td (\027\036 \024\002\255\036\n\024\n \030\036\036\022\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\n\017 \b\026\030\026\022\021\036\030\017\f\021\017\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.014 Tw T* (\022\026\n\017 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\017\n\017 \026\f\023\036\022\021\026\n\017\ \r\t\023\024\035)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc T* (\027\036\027\027\t\b \024\023\036\030\026\006\017\005.)Tj 0 Tc 0.17 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\036 \002\024\035\034\001\036\020\024 \004\017\ \f\035\026 \035\017\n\235\024\031\035\024\r )Tj 0.277 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\b \030\036\036\022\006\017\016\b \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\020)Tj 0 Tw (-)Tj 0.078 Tw T* (\n\036\027\021\026\030\027\t\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 29 \(21;48\) \023\030\024\021\017\r 20 \(15,7;32,2\), \f\024)Tj 0 Tw (-)Tj 0.204 Tw T* (\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.204 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005\), \004\026\f\021\024\021\026 \n\036\021\026\f\021\026\021\017\004\ \036\f\022\024\020\024 )Tj 0.291 Tw T* [(\023\024\030\026\032\036\027\017\016 \035\017\n\235\024\031\035\024\r )0.5(\024\022\026\026\035\026\f\034 \f\024\023\024\f\021\026\r\017\n\026)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.024 Tw -21.11 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (19)Tj /Span<>> BDC ( )Tj EMC (\(34,5%\) \027\026\002\035\033\007\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r 15 \(48,4%\) )Tj 0 Tw T* (\f\035\031\004\026\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\).)Tj 0.098 Tw T* (\200 \f\r\024\033 \024\004\036\030\036\007\034, \026\027\026\035\017 \024\ \021\007\026\035\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r\ \035\036)Tj 0 Tw (-)Tj 0.288 Tw T* [(\004\036\027\017\016 )0.5(\023\024\022\026\026\035, )0.5(\004\021\024 )0.5(5-\035\036\021\027\016\016 )0.6(\024\002\013\026\016 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )]TJ 0.236 Tw T* (\f\024\f\021\026\r\017\035\026 86% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (78,3%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.108 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.108 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,69\), \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024)Tj 0 Tw (-)Tj 0.435 Tw T* (\021\026 \r\t\016\r\035\036\027\027\t\b \024\021\007\026\035\036\027\027\ \t\b \n\036\021\026\f\021\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 10,9% )Tj 0.227 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (10,7%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.227 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \221\026\022\017\n \024\002\030\026\024\n, )Tj 0.209 Tw T* (\024\021\f\031\021\f\021\r\017\036 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.161 Tw T* [(\007\026\035\036\027\027\t\b \030\036\031\035\034\021\026\021\026\b )0.5(\023\024\r\024\035\016\036\021 \023\030\036\007\023\024\035\024\032\017\ \021\034, \004\021\024 )]TJ -0.037 Tw T* (\035\017\n\235\024\007\017\f\f\036\022\006\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \f\030\036\007\027\017\b \024\002\024\007\024\004\027\t\b\ \f\024\f\031\007\024\r )Tj 0.231 Tw T* (\007\024\f\021\026\021\024\004\027\026 \007\035\016 \024\023\031\b\024\035\ \036\005, \035\024\022\026\035\017\031\033\013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007)Tj 0 Tw (-)Tj 0.148 Tw T* (\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\004\027\024\005\ \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021)Tj 0 Tw (-)Tj 0.634 Tw T* (\f\021\r\017\017 \022\035\017\027\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )Tj 0.148 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t \002\030\t\032\036\005\022\017 \023\030\026\ \r\t\b \024\021\007\036\035\024\r \024\002\024\007\024\004\027\024\005 )Tj 0.195 Tw T* (\022\017\001\022\017. \211\007\026\035\036\027\017\036 \002\030\t\032\036\ \005\022\017 \023\030\026\r\024\005 \023\024\035\024\r\017\027\t \024\002\ \024)Tj 0 Tw (-)Tj 0.267 Tw T* [(\007\024\004\027\024\005 )0.5(\022\017\001\022\017 \f)]TJ /Span<>> BDC ( )Tj EMC [(\035\017\n\235\024\031\035\026\n\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\b\024\007\036 )0.5(\r\t\023\024\035\027\036\027\017\016 )]TJ 0.099 Tw T* (\030\026\f\001\017\030\036\027\027\t\b \r\n\036\001\026\021\036\035\034\f\ \021\r \027\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \035\024 )Tj 0.325 Tw T* (\031\035\031\004\001\036\027\017\016 \023\024\022\026\026\021\036\035\036\ \005 \r\t\032\017\r\026\036\n\024\f\021\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.215 Tw T* [(\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.036 0 Td [(\f\036\020\n\036\027\021\026\030\027\024\005 )0.6(\030\036\036\022\006\017\036\005. )0.5(\210\007\027\026\022\024 )0.6(\024\021\f\031\021\f\021\r\017\036 )]TJ 0.139 Tw -3.036 -1.218 Td (\030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \n\024\032\036\021 \002\t\021\034\ \024\002\031\f\035\024\r\035\036\027\024 )Tj 0.059 Tw T* (\021\026\022\032\036 \024\021\027\024\f\017\021\036\035\034\027\024 \027\ \036\002\024\035\034\001\017\n \023\030\036\024\002\035\026\007\026\027\017\ \036\n \024\023\031)Tj 0 Tw (-)Tj 0.103 Tw T* (\b\024\035\036\005 \030\026\027\027\017\b \f\021\026\007\017\005. \200)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\030\026\f)Tj 0 Tw (-)Tj 0.03 Tw T* (\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (63,6% \017)Tj /Span<>> BDC ( )Tj EMC (51,6% \027\026\002\035\033\007\036\027\017\005, )Tj 0.198 Tw 23.244 64.543 Td (\f\024\024\021\r\036\021\f\021\r\036\027\027\024, \027\036 \002\t\035\024\ \n\036\021\026\f\021\026\021\017\004\036\f\022\024\020\024 \023\024\030\ \026\032\036)Tj 0 Tw (-)Tj T* (\027\017\016 \035\017\n\235\024\031\035\024\r.)Tj 0.132 Tw T* (\221\026\022\032\036 \r\026\032\027\t\n \026\f\023\036\022\021\024\n \024\ \006\036\027\022\017 \220\235\235\036\022\021\017\r\027\024\f\021\017 \b\ \017)Tj 0 Tw (-)Tj 0.043 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ \016\r\035\016\036\021\f\016 \f\024\b\030\026\027\036\027\017\036 \022\026\ \004\036\f\021\r\026 )Tj 0.142 Tw T* (\032\017\027\017 \002\024\035\034\027\t\b. \210\023\030\024\f \002\024\035\ \034\027\t\b, \023\030\024\r\036\007\036\027\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.194 Tw T* (\007\026\035\036\027\027\t\036 \f\030\024\022\017 \023\024\f\035\036 \r\n\ \036\001\026\021\036\035\034\f\021\r\026, \023\024\022\026\026\035, \004\ \021\024 )Tj -0.022 Tw 0 -1.218 TD (\004\026\f\021\024\021\026 \007\036\235\036\022\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\036 \030\026\035\017\004\026\035\026\f\034\ \(2 \030\026\026/)Tj 0.035 Tw 0 -1.218 TD [(\f\031\021\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.25 0 Td [(\024\002\036\017\b )0.5(\020\030\031\023\023\026\b, )]TJ /T1_1 1 Tf 0 Tw 6.381 0 Td (p)Tj /T1_0 1 Tf 0.035 Tw /Span<>> BDC ( )Tj EMC 0.745 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.767 0 Td [(0,97\), )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.238 0 Td [(\235\024\030\n\026 )0.5(\022\026\035\026 )0.6(5 )0.5(\021\017\023\026 )]TJ 0.043 Tw -14.382 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\036 \027\036\ \002\t\035\026 \024\021\n\036\004\036\027\026 \027\017 )Tj -0.019 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \002\024\035\034\027\024\020\024, \004\021\024 \ \024\023\030\024\r\036\030\020\026\036\021 \024\023\026\f\036\027\017\016\ \027\036\022\024\021\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\030\t\b \b\017\030\031\030\020\024\r \024)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\024\n \030\017\f\022\036 \030\026\r\017\021\017\016 )0.5(\007\017\026\030\036\017 \023\024)]TJ 0 Tw (-)Tj T* (\f\035\036 \030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\ \017\017 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017.)Tj 0.198 Tw 0 -1.218 TD (\215\024\035\031\004\036\027\027\t\036 \027\026\n\017 \007\026\027\027\t\ \036 \035\017\n\017\021\017\030\024\r\026\027\t \024\020\030\026\027\017\ \004\036)Tj 0 Tw (-)Tj 0.152 Tw 0 -1.218 TD [(\027\017\016\n\017 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\n \n\024\032\027\024 \024\021\027\036\f\021\017 )0.5(\036\020\024 )]TJ 0.001 Tw 0 -1.218 TD (\030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 \b\026\030\026\022\ \021\036\030, \024\021\027\024\f\017\021\036\035\034\027\024 \027\036\002\ \024\035\034\001\031\033 )Tj 0.058 Tw T* (\r\t\002\024\030\022\031 \023\026\006\017\036\027\021\024\r \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (86\), \024\021\f\031\021\f\021\r\017\036 \036\007\017\027\t\b \023\030\024\ )Tj 0 Tw (-)Tj 0.109 Tw T* (\021\024\022\024\035\024\r \r\036\007\036\027\017\016 \002\024\035\034\027\ \t\b, \r\t\002\024\030\026 \024\002\255\036\n\026 \024\023\036\030\026\006\ \017\017 )Tj 0.218 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\026 \035\017\n\235\024\007\017\f\f\036\022\006\017\017\ , \004\021\024 \n\024\020\035\024 \f\031\013\036\f\021\r\036\027\027\024\ )Tj 0.072 Tw T* (\023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \022\024\027\021\036\022\f\021\036 \017\f\023\024\035\034\ \024)Tj 0 Tw (-)Tj T* [(\r\026\027\017\036 \215\030\024\020\030\026\n\n\t \031\f\022\024\030\036\ \027\027\024\020\024 )0.5(\r\t\007\024\030\024\r\035\036\027\017\016 )0.5(\n\024\020\035\024 )]TJ 0.175 Tw T* (\002\t \024\002\036\f\023\036\004\017\021\034 \f\021\026\027\007\026\030\ \021\017\026\006\017\033 \023\036\030\017\024\023\036\030\026\006\017\024\ \027\027\024\020\024 )Tj 0.265 Tw T* (\r\036\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\235\017\006\017\030\024\r\026\021\034 \036\020\024 \r\035\017\ \016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\t )Tj 0.262 Tw T* (\035\036\004\036\027\017\016 [12]. \003\027\026\004\017\021\036\035\034\027\ \t\n \024\020\030\026\027\017\004\036\027\017\036\n \030\026\002\024\021\ \t )Tj 0.044 Tw T* (\021\026\022\032\036 \016\r\035\016\036\021\f\016 \023\024\021\036\030\016\ \007\026\027\027\t\b 12)Tj /Span<>> BDC ( )Tj EMC (\(13,9%\) \023\026\006\017\036\027\021\024\r )Tj 0.242 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \024\021\007\026\035\036\027\027\t\b \030\036\031\ \035\034\021\026\021\024\r, \023\024\021\036\027\006\017\026\035\034\027\ \024 )Tj -0.03 Tw T* (\n\026\f\022\017\030\031\016 \030\026\035\017\004\017\016 \n\036\032\007\ \031 \020\030\031\023\023\026\n\017. \025\030\024\n\036 \021\024\020\024\ , \007\035\017)Tj 0 Tw (-)Tj 0.092 Tw T* (\021\036\035\034\027\024\f\021\034 \027\026\002\035\033\007\036\027\017\016\ \(\204\036)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52 \(34,7; 68,5\) \n\036\f\016\006\026\) )Tj 0.032 Tw T* (\n\024\032\036\021 \002\t\021\034 \027\036\007\024\f\021\026\021\024\004\ \027\024\005 \007\035\016 \024\006\036\027\022\017 \r\f\036\b \024\021\007\ \026\035\036\027)Tj 0 Tw (-)Tj 0.115 Tw T* (\027\t\b \017\f\b\024\007\024\r. \212\035\016 \r\036\030\017\235\017\022\ \026\006\017\017 \023\024\035\031\004\036\027\027\t\b \007\026\027\027\t\ \b )Tj 0.031 Tw T* (\027\036\024\002\b\024\007\017\n\t \023\030\024\f\023\036\022\021\017\r\027\ \t\036 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036 \017\f\ )Tj 0 Tw (-)Tj 0.07 Tw T* (\f\035\036\007\024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 \027\036\023\024\f\030\036\007\f\021\r\036\027\ \027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.148 Tw T* (\027\t\b \030\036\031\035\034\021\026\021\024\r \024\023\036\030\026\006\ \017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\026\004\036\f\021\r\026 \032\017\027\017 )Tj 0 Tw T* (\002\024\035\034\027\t\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 298.5998 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.702 Tw 10 0 0 10 303.3071 274.2438 Tm (\215\030\024\r\036\007\036\027\027\024\036 \017\f\f\035\036\007\024\r\026\ \027\017\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\ \024, )Tj -0.043 Tw T* (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\ \036\036\022\006\017\017 \023\024\023\036\030\036\004\027\024\005 \024\002\ \024)Tj 0 Tw (-)Tj 0.072 Tw T* (\007\024\004\027\024\005 \022\017\001\022\017 \004\026\f\021\024\021\026\ \030\026\r\017\021\017\016 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b )Tj 0.032 Tw T* (\024\f\035\024\032\027\036\027\017\005 \027\017\032\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\t\b \030\036\ \036\022)Tj 0 Tw (-)Tj 0.189 Tw T* (\006\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \030\036\020\030\036\f\f\017\024\027\027\024\020\024 \026\ \027\026\035\017\026 \002\t\035\024 \024\002\027\026\030\031)Tj 0 Tw (-)Tj 0.118 Tw T* (\032\036\027\024, \004\021\024 \024\002\255\036\n \024\023\036\030\026\006\ \017\017 \027\036 \016\r\035\016\035\f\016 \027\036\026\r\017\f\017\n\t\ \n )Tj 0.135 Tw T* (\023\030\036\007\017\022\021\024\030\024\n \030\026\r\017\021\017\016 \024\ \f\035\024\032\027\036\027\017\005. \200\036\030\024\016\021\027\024\f\021\ \034 \017\b )Tj -0.04 Tw T* [(\030\026\r\017\021\017\016 )0.5(\023\024\r\t\001\026\035\024 \017\f\023\024\035\034\024\r\026\027\017\036\ )0.5(\f\001\017\r\026\033\013\017\b )0.5(\026\023\023\026)]TJ 0 Tw (-)Tj 0.054 Tw T* (\030\026\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \n\036\032\022\017\001\036\004\ \027\024\020\024 \026\027\026\f\021\024\n\024\026 )Tj -0.001 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\005 pN2. \210\021\007\026\035\036\027\027\t\ \036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\036 )Tj 0 Tw T* (\030\026\035\017\004\026\035\017\f\034.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.399 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.8(:)]TJ /T1_1 1 Tf -0.029 Tc 0.428 Tw [( \205)-1.4(\r)-19.8(\213)-21.8(\n)-19.1(\031)-19.5(\021)]TJ /Span<>> BDC 19.624 0 Td ( )Tj EMC [(\217)-1.4(.\002.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -19.624 -1.218 Td [(\205)17.6(\r)-14.3(\032)-9.9(\031\021)-10.7(\027)-9.4(\b\022)-2.8(\025)]TJ /Span<>> BDC 4.077 0 Td ( )Tj EMC [(\036)12.8(.)33.7(\205)-12(.)-2.2(,)-10( \225)6.6(\031)-7.6(\026)-1.2(\t)0.8(\n\031\021)]TJ /Span<>> BDC 5.436 0 Td ( )Tj EMC [(\036)12.8(.)-2.7(\003)-12.2(.)]TJ /T1_0 1 Tf 0 Tc 0.81 Tw -9.513 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_1 1 Tf -0.029 Tc 0.839 Tw [( \237)-14.9(\020)-20.3(\021)-35.6(\f)-20(\020)-28.1(\027)-22.4(\021)]TJ /Span<>> BDC 19.299 0 Td ( )Tj EMC [(\002.\206)65(.)-21.2(,)-29.1( )]TJ 0 Tc 0 Tw -19.299 -1.218 Td [(\221)3.8(\f)-0.9(\r)7.1(\030)1.9(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.4(.)43.7(\217)27.6(.)7.8(, \036)-7.6(\f)3.4(\203)5.4(\022)4.7(\026)4(\031)9.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\224)26.6(.)7.3(\003)-2.3(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (132)Tj ET endstream endobj 704 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.028 Tw 10 0 0 10 274.9606 298.5999 Tm (\212\036\235\036\022\026\006\017\016 3 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017, \004\021\024 \n\024\032\036\021 \f\024\024\021\r\036\ \021)Tj 0 Tw (-)Tj 0.249 Tw 0 -1.218 TD [(\f\021\r\024\r\026\021\034 \024\023\030\036\007\036\035\036\027\017\033 \ )0.5(\253\007\017\026\030\036\016\273, \002\t\035\026 \026\030\036\020\017\f\ \021\030\017)]TJ 0 Tw (-)Tj 0.202 Tw T* (\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (3/28 \(10,7%\) \027\026\002\035\033\007\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f)Tj 0 Tw (-)Tj 0.019 Tw T* (\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031 1/46 \(1,82%\) \023\026\006\017\036\027\021\026 \023\024\f\035\036 \ )Tj 0.091 Tw T* (\f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022\006\017\017\ [11]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \023\026\030\026\n\036\021\030\031 )Tj 0.039 Tw T* (\020\030\031\023\023\t \002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t\ \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.039 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,1\). \211)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\020\024 )Tj 0.047 Tw T* [(\002\024\035\034\001\017\027\f\021\r\026 )0.6(\002\024\035\034\027\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.178 0 Td [(\020\030\031\023\023\026\b )0.5(\022\026\035 )0.6(\017\n\036\035 )0.5(\235\024\030\n\031, )0.5(\f\024)]TJ 0 Tw (-)Tj -0.014 Tw -10.178 -1.218 Td (\024\021\r\036\021\f\021\r\031\033\013\026\016 \021\017\023\031 3 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\036. \222\021\ \031\035 5, )Tj 0.102 Tw T* (6 \017)Tj /Span<>> BDC ( )Tj EMC (7 \021\017\023\026, \b\026\030\026\022\021\036\030\027\t\005 \007\035\016\ \007\017\026\030\036\017, \002\024\035\034\027\t\036 \024\002\036\017\b\ )Tj 0 Tw T* (\020\030\031\023\023 \027\036 \024\021\n\036\004\026\035\017 \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 152.4639 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.024 Tc 0.264 Tw 10 0 0 10 274.9606 128.1078 Tm (\215\030\024\r\036\007\036\027\027\024\036 \017\f\f\035\036\007\024\r\026\ \027\017\036 \r\t\016\r\017\035\024 \f\021\026\021\017\f\021\017\004\036\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.069 Tw T* (\f\022\017 \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\036 \024\ \002\013\036\005 \004\026\f\021\024\021\t \023\024\f\035\036\024\023\036\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.146 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.154 Tw T* (\006\017\017 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033)24( )]TJ 0.066 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\n\017 \r\n\036\001\026\021\036\035\034\ \f\021\r\026\n\017)Tj /Span<>> BDC ( )Tj EMC [(\227 20% \023\030\024\021\017\r)24( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\b\032\027\024\024\022\031\025\025\013\235 \020\025\020\f\022\016\ \033\032\027\030\022\n\023\031\032\031\021 \032\020\016\021\022\023\022\ \t \031\024\f\031\255\025\027\025\022\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.323 0 Td [( R)2.8(e)-7.7(g)-1.5(r)-1.9(e)-22.1(s)-10.4(s)-12.5(i)-1.4(o)-4(n a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-2.8(r)-2(e)-12.9(d)-3(i)-1.7(c)-32.4(t)-3(o)-3(r)-14.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-4.9(li)-1.8(c)3.2(a)-9.1(t)-29.1(i)-1.4(o)-4(n)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 703.7118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 201.5098 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 348.9114 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 496.313 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 201.2598 703.7118 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 201.5098 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 348.9114 703.7118 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 703.7118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 692.2426 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 692.2426 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 692.2426 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 692.2426 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7813 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 680.7813 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 680.7813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 680.7813 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 680.7813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.32 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 669.32 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 669.32 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 669.32 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 669.32 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8588 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 657.8588 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 657.8588 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 657.8588 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 657.8588 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.3975 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 646.3975 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 646.3975 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 646.3975 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 646.3975 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.9362 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 634.9362 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 634.9362 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 634.9362 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 634.9362 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 623.4749 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 623.4749 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 623.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 623.4749 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 623.4749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 612.0136 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 612.0136 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 612.0136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 612.0136 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 612.0136 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 600.5523 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 600.5523 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 600.5523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 600.5523 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 600.5523 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 589.0911 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 589.0911 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 589.0911 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 589.0911 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 589.0911 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 577.6298 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 577.6298 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 577.6298 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 577.6298 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 577.6298 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.1685 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 201.5098 566.1685 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 303.5571 566.1685 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 348.9114 566.1685 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 450.9586 566.1685 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 102.5001 700.8118 Tm (\200\004\006\004\214\r\003\006\013)Tj 16.478 0.717 Td (\222\b\t\004\006\t\004\b\003\b\013\005 \004\b\004\f\t\213)Tj 17.657 0 Td (\215\210\f\001\003\t\004\006\t\004\b\003\b\013\005 \004\b\004\f\t\213)Tj -18.381 -1.434 Td (\017\016 \(95% \031\034\))Tj /T1_5 1 Tf 11.953 0.001 Td (\t)Tj /T1_4 1 Tf 6.473 -0.001 Td (\017\016 \(95% \031\034\))Tj /T1_5 1 Tf 11.953 0.001 Td (\t)Tj /T1_1 1 Tf -53.244 -1.433 Td (\200\024\030\026\f\021)Tj 22.574 0 Td (1,05)Tj /Span<>> BDC ( )Tj EMC (\(0,99\2261,12\))Tj 11.662 0 Td (0,07)Tj 7.356 0 Td (1,06)Tj /Span<>> BDC ( )Tj EMC (\(1\2261,14\))Tj 11.07 0 Td (0,07)Tj -52.661 -1.433 Td (\215\024\035 \(\n\031\032\f\022\024\005\))Tj 22.824 0 Td (0,76)Tj /Span<>> BDC ( )Tj EMC (\(0,24\2262,2\))Tj 11.662 0 Td (0,6)Tj -34.486 -1.433 Td (\230\027\007\036\022\f \n\026\f\f\t \021\036\035\026)Tj 22.574 0 Td (0,97)Tj /Span<>> BDC ( )Tj EMC (\(0,86\2261,09\))Tj 11.662 0 Td (0,63)Tj -34.236 -1.433 Td (ASA II/III)Tj 22.574 0 Td (0,67)Tj /Span<>> BDC ( )Tj EMC (\(0,23\2261,90\))Tj 11.662 0 Td (0,45)Tj -34.236 -1.433 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005 \007\024\ \f\021\031\023)Tj 22.574 0 Td (1,12)Tj /Span<>> BDC ( )Tj EMC (\(0,35\2263,30\))Tj 11.662 0 Td (0,84)Tj -34.236 -1.433 Td (\025\030\024\r\024\023\024\021\036\030\016)Tj 23.167 0 Td (0,99)Tj /Span<>> BDC ( )Tj EMC (\(0,99\2261\))Tj 11.07 0 Td (0,63)Tj -34.236 -1.433 Td (\202\023\023\026\030\026\021\027\t\005 \026\027\026\f\021\024\n\024)Tj 22.324 0 Td (8,33)Tj /Span<>> BDC ( )Tj EMC (\(1,82\22644,92\))Tj 11.662 0 Td (0,007)Tj 6.763 0 Td (9,48)Tj /Span<>> BDC ( )Tj EMC (\(1,88\22657,66\))Tj 11.662 0 Td (0,008)Tj -52.411 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017)Tj 23.167 0 Td (0,99)Tj /Span<>> BDC ( )Tj EMC (\(0,98\2261\))Tj 11.07 0 Td (0,63)Tj -34.236 -1.433 Td (\030N2)Tj 22.324 0 Td (3,53)Tj /Span<>> BDC ( )Tj EMC (\(1,19\22610,69\))Tj 11.912 0 Td (0,02)Tj 6.513 0 Td (3,63)Tj /Span<>> BDC ( )Tj EMC (\(1,11\22612,34\))Tj 11.912 0 Td (0,03)Tj -52.661 -1.433 Td (\030\2214b)Tj 22.759 0 Td (3,2)Tj /Span<>> BDC ( )Tj EMC (\(0,58\22616,05)Tj 11.477 0 Td (0,15)Tj -34.236 -1.433 Td (\217\026\f\001\017\030\036\027\027\026\016 \030\036\036\022\006\017\016\ \024\002\024\007\024\004\027\024\005 \022\017\001\022\017)Tj 22.824 0 Td (2,8)Tj /Span<>> BDC ( )Tj EMC (\(0,97\2268,33\))Tj 11.412 0 Td (0,11)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 549.4492 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\023\030\020\f\027\025\025\013\027 \032\027\016\r\f\017\023\020\023\ \013 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.002 Tc -0.002 Tw 3.329 0 Td [( L)-7.7(o)-2(n)1.4(g)-11.7(-)-7.4(te)-3.9(r)-16.6(m)2( re)-20(s)8.7(ul)7.3(t)-30.9(s)2( i)5.9(n)2( g)0.5(ro)-1.4(up)3.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 534.1472 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 534.1472 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 534.1472 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 534.1472 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 522.678 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 522.678 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 522.678 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 522.678 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 511.2088 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 511.2088 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 511.2088 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 511.2088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 499.7475 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 499.7475 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 499.7475 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 499.7475 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 488.2862 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 488.2862 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 488.2862 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 488.2862 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 476.8249 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 476.8249 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 476.8249 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 476.8249 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 465.3636 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 224.187 465.3636 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 465.3636 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 450.9586 465.3636 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 8 0 0 8 116.7386 525.5126 Tm (\200\004\006\004\214\r\003\006)Tj 15.36 0 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 14.227 0 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj /T1_5 1 Tf 14.766 0.001 Td (\t)Tj /T1_4 1 Tf -53.244 -1.434 Td (\200\006\002\217\f\r\202\r\b\002 \206\002\f\001\b\013\216, )Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf ( \(%\))Tj 27.311 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(83,6\))Tj 14.173 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(90,3\))Tj /T1_1 1 Tf 10.677 0.001 Td (0,52**)Tj -52.161 -1.434 Td (\202\007\255\033\r\026\027\021\027\026\016 \b\017\n\017\024\021\036\030\026\ \023\017\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 27.201 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(52,8%\))Tj 14.173 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(64,3%\))Tj 10.787 0 Td (0,34**)Tj -52.161 -1.433 Td (\215\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\016, \204\036\ \(Q1; Q3\))Tj 26.808 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(41; 79,5\))Tj 13.488 0 Td (41,5)Tj /Span<>> BDC ( )Tj EMC (\(28,5; 64,7\))Tj 11.865 0 Td (0,08**)Tj -52.161 -1.433 Td (\210\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 27.451 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10,9%\))Tj 14.173 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\))Tj 11.037 0 Td (1,0*)Tj -52.661 -1.433 Td (5-\035\036\021\027\016\016 \210\200, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 28.53 0 Td (86%)Tj 13.831 0 Td (78,3%)Tj 9.551 0 Td (0,69***)Tj /T1_2 1 Tf 7 0 0 7 42.5197 453.879 Tm (\004\032\022\026\027\007\020\025\022\027: \215)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \020\032\022\203\026\027\023\022\007\027\ \024\n\031\027, SD)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\020\025\030\020\032\023\025\031\027 \031\023\n\f\031\025\027\ \025\022\027; *)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\027\024\023)0.7( \214\022\213\027\032\020; **)]TJ /Span<>> BDC ( )Tj EMC (\227 t-\n\032\022\023\027\032\022\235 \205\023\017\005\030\027\025\023\020\ ; ***)Tj /Span<>> BDC ( )Tj EMC (\227 \f\031\b-\032\020\025\b\031\021\013\235 )Tj 0 -1.2 TD (\023\027\024\023.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 426.1751 Tm (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \024\023\r\f\020 \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.076 Tc 0.076 Tw T* [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.25 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e c)-2.5(ha)-6.2(i)4.9(r i)3.9(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 410.8731 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 410.8731 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 410.8731 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 410.8731 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 410.8731 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 399.4039 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 399.4039 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 399.4039 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 399.4039 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 399.4039 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 387.9347 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 387.9347 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 387.9347 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 387.9347 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 387.9347 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 376.4734 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 376.4734 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 376.4734 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 376.4734 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 376.4734 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 365.0121 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 343.9508 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 184.502 365.0121 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 184.502 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 224.187 365.0121 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 365.0121 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9586 365.0121 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.7697 332.7395 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.252 343.9508 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 184.502 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 343.9508 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 343.9508 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 343.9508 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 332.4895 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 184.502 332.4895 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 332.4895 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 332.4895 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 450.9586 332.4895 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 116.7386 402.2385 Tm (\200\004\006\004\214\r\003\006)Tj 15.36 0 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 14.227 0 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235)Tj /T1_5 1 Tf 14.766 0.001 Td (\t)Tj /T1_4 1 Tf -53.244 -1.434 Td (\200\006\002\217\f\r\202\r\b\002 \206\002\f\001\b\013\216, )Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf ( \(%\))Tj 27.311 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(83,6\))Tj 14.173 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(90,3\))Tj /T1_1 1 Tf 10.927 0.001 Td (0,52*)Tj -52.411 -1.434 Td (\232\026\f\021\024\021\026 \f\021\031\035\026, \204\036 \(Q1; Q3\))Tj 28.017 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 14.173 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 10.221 0 Td (1,0**)Tj -52.411 -1.433 Td (\222\021\031\035 3 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 27.451 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,82%\))Tj 14.173 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\))Tj 11.037 0 Td (0,1*)Tj -52.661 -1.433 Td (\221\017\023 \022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 )Tj T* (\001\022\026\035\024\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 19.593 1.2 Td (3)Tj T* (4)Tj 7.608 1.2 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(67,4%\))Tj T* (15)Tj /Span<>> BDC ( )Tj EMC (\(32,6%\))Tj 14.173 1.2 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(71,4%\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(28,6%\))Tj 10.537 1.2 Td (0,80**)Tj -33.097 -2.633 Td (5\2267)Tj 10.095 0 Td (0)Tj 14.173 0 Td (0)Tj 9.893 0 Td (\226)Tj /T1_2 1 Tf 7 0 0 7 42.5197 321.0049 Tm (\004\032\022\026\027\007\020\025\022\027: \215\027)Tj /Span<>> BDC ( )Tj EMC (\227 \026\027\030\022\020\025\020; Q1, Q3)Tj /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023)0.7(\027\024\023 \215\020\025\025\020\231\210)50(\022\023\025\022; ***)]TJ /Span<>> BDC ( )Tj EMC (\227 \250)Tj 4.081 0 0 4.081 381.0127 323.3359 Tm (2)Tj 7 0 0 7 383.0532 321.0049 Tm ( \004\022\032\024\031\025\020.)Tj ET q 42.52 100.97 221.102 179.702 re W n q /GS0 gs 221.1023475 0 0 179.8107056 42.5196833 100.861898 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \202\032\022\021\013\027 \021\013\255\022\021\020\027\026\031\024\023\022\ \202\020\033\f\020\025\020-\215\027\235\027\032\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( K)17(aplan-Meyer sur)-41.9(viv)16(al cur)-41.9(v)13(es)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.6396 56.0378 Tm (131)Tj ET endstream endobj 705 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,w""   !12ASU "#$%&'()*3456789:BCDEFGHIJQRTVWXYZabcdefghijqrstuvwxyz!1A"Qa2qB3r #$%&'()*456789:CDEFGHIJRSTUVWXYZbcdefghijstuvwxyz?0ؾzL>m<,:q]JV59K*}: y1%֓éRMYN Ъ0uEbTUU44m$l.q SX4QCTV*yE`ζ>`ғQEu᪴xJslg[}hgeVTUbSF&%4衴vϜ푩~;M>]-RiiiS\gֽ]wYs3zR*œhĭڦk};I֯5-Ygvxu'KV|XѪ0!?Z'4Zp2®jţ::TE}ޭcvWc)z*vg̵6~e/ER^5GZ濥>.(;j _՟aUY*[sG,-;))CNZyrMX*Bz*r$) ,2XdYie ffrzwpRJXe@Wh㒈H⮳SK$SJXs\jx|V%Y+L:Q)s'Z\Ǐ̼J\чO;XuUTUf&- mCDuҩir%oiJ g٣~g7 Ϫ͚8wzZ:~gpO5 Oc?kXfR$sQI%9f!r,ҭE-@n SEIQS432A,ReSY$,^~%tK5NRzMVjS٩DV54%'RkXڅڐJPѼ)ȴNr8Ҫ0=STҥIj`|3Jy@<,Z*ĢMTWKR4ᦸ4s672Wι,LՓMYkUKiM-5m5]uu VVNyl铞Ce}=Ο4'dO;7Pd1W[faJ0 >׶+)s1E|ԩ^ J畺XS @Ovxu'KV|Y򝴞;j _՟&~DTF| baSrӛl0ұ4Dug("*))!rI)-;PնgRZCz*94SS]tRXo^'Jd@*j&ٜ\CSE$MFMIeE rC 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(\022\030\017\021\036\030\017\016\n N0, N1 \017)Tj /Span<>> BDC ( )Tj EMC (N2 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017)Tj 0 Tw (-)Tj T* (\n\024 \027\036 \030\026\035\017\004\026\035\024\f\034 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.056 Tw T* (\215\024\f\022\024\035\034\022\031 \f\235\024\030\n\017\030\024\r\026\027\ \027\t\036 \r\t\002\024\030\022\017 \002\t\035\017 \027\036\f\024\023\024\ \f)Tj /Span<>> BDC (-)Tj EMC 0.032 Tw T* (\021\026\r\017\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \r\026\032\027\t\b \235\026\022\021\024\030\024\r, \021\ \026\022\017\b \022\026\022 \r\024\030\026\f\021, )Tj 0.197 Tw T* (\017\027\007\036\022\f \022\024\n\024\030\002\017\007\027\024\f\021\017 \ \232\026\030\035\f\024\027\026, \f\023\024\f\024\002 \235\024\030\n\017\030\ \024)Tj 0 Tw (-)Tj 0.032 Tw T* (\r\026\027\017\016 \026\027\026\f\021\024\n\024\026, \007\035\017\021\036\ \035\034\027\024\f\021\034 \024\023\036\030\026\006\017\017, \004\021\024\ \n\024\020\035\024 )Tj 0.051 Tw T* (\024\022\026\t\r\026\021\034 \f\031\013\036\f\021\r\036\027\027\024\036\ \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\027\t\036 \030\036)Tj 0 Tw (-)Tj -0.082 Tw T* (\031\035\034\021\026\021\t, \007\035\016 \002\024\035\036\036 \024\002\255\ \036\022\021\017\r\027\024\005 \024\006\036\027\022\017 \027\026\n\017 \002\ \t\035 \r\t)Tj 0 Tw (-)Tj -0.059 Tw T* (\023\024\035\027\036\027 \030\036\020\030\036\f\f\017\024\027\027\t\005 \ \026\027\026\035\017 \007\026\027\027\t\b, \027\026\023\030\026\r\035\036\ \027\027\t\005 )Tj 0.321 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \023\030\036\007\017\022\021\024\030\024\r\ \030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\005. )Tj 0.1 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 \023\030\024\r\036\007\036\027\027\ \024\020\024 )0.5(\031\027\017\r\026\030\017\026\027\021\027\024\020\024 )0.5(\235\026\022\021\024\030)]TJ 0 Tw (-)Tj 0.098 Tw T* [(\027\024\020\024 )0.5(\026\027\026\035\017\026 )0.6(\017\n\017 )0.5(\024\022\026\026\035\017\f\034: )0.6(\026\023\023\026\030\026\021\027\t\005 )0.6(\026\027\026\f\021\024\n\024 )]TJ 0.071 Tw T* (\(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8,33; 95% \212\230: 1,82\22644,92; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.071 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\016 )Tj -0.041 Tw T* (pN2 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,53; 95% \212\230: 1,19\22610,69; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \200)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034)Tj 0 Tw (-)Tj 0.226 Tw T* (\021\017\r\026\030\017\026\027\021\027\024\005 \n\024\007\036\035\017 \027\ \036\026\r\017\f\017\n\t\n\017 \023\030\036\007\017\022\021\024\030\026\ \n\017 )Tj 0.285 Tw T* (\024\f\035\024\032\027\036\027\017\005 \024\f\021\026\035\017\f\034 \021\ \036 \032\036 \235\026\022\021\024\030\t: \026\023\023\026\030\026\021\027\ \t\005 )Tj 0.154 Tw T* (\f\023\024\f\024\002 \235\024\030\n\017\030\024\r\026\027\017\016 \026\027\ \026\f\021\024\n\024\026 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9,48; 95% )Tj 0.088 Tw T* (\212\230: 1,88\22657,66; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.088 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\016 pN2 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,63; )Tj 0.087 Tw T* (95% \212\230: 1,11\22612,34; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.087 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \215\024\f\021\030\024\036\027\027\026\016 \n\031\035\034\021\017\ )Tj 0 Tw (-)Tj 0.244 Tw T* (\r\026\030\017\026\027\021\027\026\016 \035\024\020\017\f\021\017\004\036\ \f\022\026\016 \n\024\007\036\035\034 \023\030\017\027\026\027\026 \031\ \f\021\024\005)Tj 0 Tw (-)Tj 0.38 Tw T* (\004\017\r\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \f\024\024\021\r\036\021\f\021\r\031\033\ \013\017\b \022\030\017\021\036\030\017\036\r: )Tj 0.29 Tw 23.244 40.187 Td (\024\021\027\024\001\036\027\017\036 \023\030\026\r\007\024\023\024\007\024\ \002\017\016 \(LR\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (16; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.29 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0011; )Tj 0.183 Tw T* (\022\030\017\021\036\030\017\005 \216\024\f\n\036\030\026\226\214\036\n\036\ \001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6,53, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.183 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,5886; R)Tj 0 Tw 5.83 0 0 5.83 521.4944 472.4219 Tm (2 )Tj 0.237 Tw 10 0 0 10 303.3071 456.9139 Tm (\204\026\022\235\026\007\007\036\027\026)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18. \222\035\036\007\031\036\021 \023\024\007\004\036\030\022\027\031\021\ \034, \004\021\024 \030\026\f)Tj 0 Tw (-)Tj 0.498 Tw T* (\001\017\030\036\027\027\t\005 \017\035\017 \f\036\020\n\036\027\021\026\ \030\027\t\005 \b\026\030\026\022\021\036\030 \030\036\036\022\006\017\017\ )Tj 0.285 Tw T* (\027\026\004\017\n\024 \027\036 \r\035\017\016\035 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\035\ \034\021\026)Tj 0 Tw (-)Tj 0.094 Tw T* [(\021\t )0.6(\035\036\004\036\027\017\016 )0.6(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 7.097 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(2,8; )0.6(95% )0.5(\212\230: )0.6(0,97\2268,33; )]TJ /T1_1 1 Tf 0 Tw 10.316 0 Td (p)Tj /T1_0 1 Tf 0.094 Tw /Span<>> BDC ( )Tj EMC 0.804 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td (0,11\), )Tj 0 Tw -19.87 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \031\027\017\r\026\030\017\026\027\021\027\024\020\024\ \026\027\026\035\017\026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.041 Tw T* (\210\021\007\026\035\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t \023\030\024\f\035\036\032\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (46/55 \(83,6%\) )Tj -0.01 Tw T* [(\023\026\006\017\036\027\021\024\r )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.241 0 Td [(\020\030\031\023\023\036 )0.6(\f\036\020\n\036\027\021\026\030\027\024\005 )0.5(\030\036\036\022\006\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 13.759 0 Td [(\031 )0.5(28/31 )]TJ 0.381 Tw -19 -1.218 Td (\(90,3%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022)Tj 0 Tw (-)Tj 0.132 Tw T* (\006\017\017. \215\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \020\030\031\023\023\036 \f\024\f\021\026\r\017\035\ )Tj 0.083 Tw T* [(55 )0.5(\(41; )0.5(79,5\) )0.6(\n\036\f\016\006\036\r, )0.5(\r\024 )0.5(\r\021\024\030\024\005)]TJ /Span<>> BDC ( )Tj EMC 14.058 0 Td [(\227 )0.5(41,5 )0.5(\(28,5; )0.6(64,7\) )]TJ 0.194 Tw -14.058 -1.218 Td (\n\036\f\016\006 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.194 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,08\). \202\007\255\033\r\026\027\021\027\026\016 \b\017\n\017\024\021\036\ \030\026\023\017\016 \002\t\035\026 )Tj 0.206 Tw T* (\023\030\024\r\036\007\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (24)Tj /Span<>> BDC ( )Tj EMC (\(52,8%\) \023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\ \001\017\b \222\217 )Tj 0.073 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031 18)Tj /Span<>> BDC ( )Tj EMC (\(64,3%\) \023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\ \001\017\b \217\217 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.073 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34\). )Tj 0.286 Tw T* (\210\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t \002\t\ \035\017 \r\t\016\r\035\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(8,7%\) )Tj -0.038 Tw T* (\002\024\035\034\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\031 3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.011 Tw T* (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.011 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \204\036\f\021\027\t\b \030\036\006\017\007\017\r\024\r )Tj 0 Tw T* (\026\002\024\035\036\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\036 \026\235\017\022\f\017\030\024\r\026\ \027\024.)Tj 0.147 Tw T* (\215\030\017 \024\006\036\027\022\036 \024\002\013\036\005 \r\t\032\017\r\ \026\036\n\024\f\021\017 \n\036\007\017\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b )Tj 0.086 Tw T* (\020\030\031\023\023\026\b \027\036 \007\024\f\021\017\020\027\031\021\t\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \n\026\035\024\020\024 \004\017\f\035\026 \f\ \024)Tj 0 Tw (-)Tj 0.094 Tw T* (\002\t\021\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \023\030\036\007\f\021\026\r\035\036\027\026 \007\024\035\ \016 \r\t\032\017\r\001\017\b )Tj 0.103 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\017\030\024\r\026\027\027\t\b \020\024\030\017\024\027\021\ \026\b. \221\026\022, 5-\035\036\021\027\016\016 \210\200 \f\024)Tj 0 Tw (-)Tj 0.17 Tw T* (\f\021\026\r\017\035\026 86%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (78,3%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.254 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017, \020\030\031\023\023\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n\031 )Tj 0.465 Tw T* [(\023\030\017\027\026\022\031 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )0.5(\027\026\004\017\n\024 \027\036 \030\026\035\017\004\026\035\017\f\034\ )]TJ 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,69\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.495 Tw T* (\230\031\004\036\027\017\036 \004\026\f\021\024\021\t \007\036\235\036\022\ \026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.441 Tw T* (\032\036 \235\024\030\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\017\f\021\036\027\006\017\017 \022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.073 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\024\005, \023\ \030\024\r\024\007\017\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \021\036)Tj 0 Tw (-)Tj 0.025 Tw T* (\035\036\235\024\027\027\024\020\024 \024\023\030\024\f\026. \207\t\035\024\ \024\002\027\026\030\031\032\036\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.188 Tw T* (\027\024\n \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\ \n \023\036\030\017\024\007\036 \007\026\027\027\t\005 \023\026\030\026\n\ \036\021\030 )Tj 0.161 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\036\017\b \020\030\031\023\023\026\b \027\036 \030\026\035\017\ \004\026\035\f\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035 2 \(1; 2\) )Tj 0 Tw T* (\007\036\235\036\022\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,97\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \206\027\016\r\f\017\023\020\023\013 \033\020\023\031\026\031\032\203\031\ \f\031\b\022\007\027\024\n\031\b\031 \022\024\024\f\027\030\031\021\020\025\ \022\t \031\033\027\032\020\006\022\031\025)0.5(\025\013\200 \033\032\027\033\020\032\020\023\031\021 \021)]TJ /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 3.337 0 Td [( R)4.8(e)-20(s)8.7(u)0.5(l)7.2(t)-30.9(s)2.1( o)6(f)]TJ /Span<>> BDC 4.088 0 Td ( )Tj EMC [(t)-8.6(he)2( p)-4.3(a)-7.2(t)-8.6(ho)-1.9(m)-3.3(o)-1(r)-22.3(p)0.9(ho)-3.3(lo)-6.6(g)-16.7(ic)5.3(a)-2.5(l)2( e)-30.4(x)2.5(a)-3.1(m)3.3(i)5.9(n)2.4(a)-7.1(t)-27.1(i)0.6(o)-2(n)2( o)6(f)]TJ /Span<>> BDC 15.91 0 Td ( )Tj EMC [(s)8.7(u)3.6(rg)-16.7(ic)5.2(a)-2.4(l)2( p)-0.8(re)-5.7(p)-4.3(a)-2.2(r)5.3(a)-7.2(t)-27.1(i)0.6(o)-1.9(n)5.7(s)2( i)5.9(n)2( g)0.5(ro)-1.4(up)3.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 715.181 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 391.4311 715.181 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 303.5571 694.1118 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 391.4311 694.1118 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 479.3051 694.1118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 653.8505 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 303.5571 653.8505 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 391.4311 653.8505 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 479.3051 653.8505 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 524.6594 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 70.8661 594.3892 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 594.3892 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 594.3892 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 594.3892 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 582.928 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 582.928 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 582.928 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 582.928 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 571.4667 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 303.5571 571.4667 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 391.4311 571.4667 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 479.3051 571.4667 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 540.8054 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 540.8054 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 540.8054 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 540.8054 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 529.3441 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 529.3441 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 529.3441 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 529.3441 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 517.8828 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 303.5571 517.8828 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 517.8828 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 479.3051 517.8828 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 8 0 0 8 170.5969 701.7465 Tm (\200\004\006\004\214\r\003\006)Tj -0.04 Tw 16.974 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 0 Tw 3.306 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 7.712 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_3 1 Tf 9.899 0.6 Td (p)Tj /T1_0 1 Tf -53.244 -2.033 Td (\222\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\030\ \024\r\022\017 \024\023\031\b\024\035\017 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (Grade I)Tj T* (Grade II)Tj T* (Grade III)Tj 31.551 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10,9\))Tj 0.092 -1.2 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(60\))Tj -0.343 -1.2 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(29,1\))Tj 12.563 2.4 Td (0)Tj -1.579 -1.2 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(67,7\))Tj T* (10)Tj /Span<>> BDC ( )Tj EMC (\(32,3\))Tj 9.063 3.6 Td (0,16*)Tj -52.411 -5.033 Td (\206\035\031\002\017\027\026 \017\027\r\026\017\017, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (T1)Tj T* (T2)Tj T* (T3)Tj 0 -1.2 TD (T4a)Tj 0 -1.2 TD (T4b)Tj 31.801 4.8 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,1\))Tj -0.5 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(18,2\))Tj 0 -1.2 TD (18)Tj /Span<>> BDC ( )Tj EMC (\(32,7\))Tj 0 -1.2 TD (19)Tj /Span<>> BDC ( )Tj EMC (\(34,5\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,4\))Tj 12.063 4.8 Td (0)Tj -1.079 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj -0.5 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(35,5\))Tj T* (14)Tj /Span<>> BDC ( )Tj EMC (\(45,2\))Tj 0.25 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(12,9\))Tj 8.313 6 Td (0,15)Tj /T1_1 1 Tf (***)Tj /T1_0 1 Tf -51.911 -7.433 Td (\210\002\013\036\036 \022\024\035\017\004\036\f\021\r\024 \035\017\n\235\ \024\031\035\024\r, \204\036 \(Q1; Q3\))Tj 31.249 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(15,7; 32,2\))Tj 11.669 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(21; 48\))Tj 8.993 0 Td (0,005**)Tj -51.911 -1.433 Td (\025\024\035\017\004\036\f\021\r\024 \n\036\021\026\f\021\026\021\017\004\ \036\f\022\017\b \023\024\030\026\032\036\027\027\t\b \035\017\n\235\024\ \031\035\024\r, \204\036 \(Q1; Q3\))Tj 32.684 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 4\))Tj 10.984 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 4\))Tj 8.493 0 Td (0,49**)Tj -52.161 -1.433 Td (N0 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (N1 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (N2 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.984 2.4 Td (35)Tj /Span<>> BDC ( )Tj EMC (\(63,6%\))Tj 0.5 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,1%\))Tj -0.121 -1.2 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(25,4\))Tj 10.605 2.4 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(51,6%\))Tj 0.25 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(16,1%\))Tj -0.25 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(32,3%\))Tj 8.943 2.4 Td (0,44***)Tj -51.911 -3.833 Td (\214\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 \017\027\r\026\ \017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.984 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(50,9%\))Tj 11.364 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(71,0\))Tj 9.063 0 Td (0,11*)Tj -52.411 -1.433 Td (\200\036\027\024\027\026\016 \017\027\r\026\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.984 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(34,5%\))Tj 11.614 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(29,0\))Tj 9.063 0 Td (1,0*)Tj /T1_1 1 Tf 7 0 0 7 70.8661 506.3982 Tm (\004\032\022\026\027\007\020\025\022\027: \215\027)Tj /Span<>> BDC ( )Tj EMC (\227 \026\027\030\022\020\025\020; Q1, Q3)Tj /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023)0.7(\027\024\023 \215\020\025\025\020\231\210)50(\022\023\025\022; ***)]TJ /Span<>> BDC ( )Tj EMC (\227 \250)Tj 4.081 0 0 4.081 409.3591 508.7292 Tm (2)Tj 7 0 0 7 411.3996 506.3982 Tm ( \004\022\032\024\031\025\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (130)Tj ET endstream endobj 749 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.179 Tw 10 0 0 10 42.5197 310.7779 Tm (\030\036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (54 \(98,2%\) \002\024\035\034\027\t\b, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 )Tj 0.303 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (24 \(77,4%\) )Tj 0.138 Tw T* (\023\026\006\017\036\027\021\024\r \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.138 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,003\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\017 \f\022\024\030\024\f\021\017 \r\024\f)Tj 0 Tw (-)Tj 0.261 Tw T* (\f\021\026\027\024\r\035\036\027\017\016 \n\024\021\024\030\027\024\005 \ \235\031\027\022\006\017\017 \032\036\035\031\007\024\004\027\024-\022\017\ \001\036\004)Tj 0 Tw (-)Tj 0.356 Tw T* [(\027\024\020\024 )0.5(\021\030\026\022\021\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.769 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036, )0.6(\002\t\035\024 )]TJ 0.223 Tw -6.769 -1.218 Td (\024\021\n\036\004\036\027\024, \004\021\024 \r\030\036\n\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\020\024 \024\021\b\024\032\007\036\027\017\016 \020\026\ \024\r )Tj 0.138 Tw T* (\027\036 \030\026\035\017\004\026\035\024\f\034, \n\036\007\017\026\027\ \026 \220\021\024\020\024 \023\024\022\026\026\021\036\035\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.109 Tw T* (\f\036\020\n\036\027\021\026\030\027\024\005 \f\024\f\021\026\r\017\035\026\ 2 \(1; 3\) \f\031\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (2 \(2; 3\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.153 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.859 0 Td [(\020\030\031\023\023\036 )0.6(\030\026\f\001\017\030\036\027\027\024\005 )0.5(\030\036\036\022\006\017\017 )0.6(\()]TJ /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.153 Tw /Span<>> BDC ( )Tj EMC 14.643 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.885 0 Td [(0,42\). )0.5(\210\007\027\026\022\024 )]TJ 0.034 Tw -16.388 -1.218 Td (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \020\030\031\023\023\t \030\026\f\001\ \017\030\036\027\027\024\005 \030\036\036\022\006\017\017 \002\t\035\024\ \026)Tj 0 Tw (-)Tj 0.236 Tw T* (\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \002\024\035\036\036\ \030\026\027\027\036\036 \024\021\b\024\032\007\036\027\017\036 \023\036\ \030\r\024\020\024 )Tj 0.001 Tw T* (\f\021\031\035\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \(2; 4\) \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016, )Tj 0.142 Tw T* (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\ \036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (4 \(3; 5\) )Tj 0.101 Tw T* (\f\031\021\022\017 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.101 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\). \222\030\024\022\017 \023\030\036\002\t\r\026\027\017\016 \023\024\ \f\035\036 \024\023\036\030\026\006\017\017 )Tj 0.092 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\006\017\024\027\026\030\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 )0.5(\f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022\006\017\017\ )0.5(\002\t\035\017 )]TJ 0.143 Tw T* (\022\024\030\024\004\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027 \007\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 8 \(6; 10\) \023\030\024\021\017\r 9 \(7; 11\), )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.576 Tw T* (\210\f\035\024\032\027\036\027\017\016 \030\026\r\017\035\017\f\034 \031\ )Tj /Span<>> BDC ( )Tj EMC (11/55 \(20%\) \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.163 Tw T* [(\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.619 0 Td [(\020\030\031\023\023\036 )0.5(\222\217 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.468 0 Td [(\031 )0.5(13/31 )0.5(\(41,9%\))]TJ /Span<>> BDC ( )Tj EMC 7.258 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.265 0 Td [(\020\030\031\023\023\036 )0.5(\217\217. )]TJ 0.3 Tw -17.611 -1.218 Td (\215\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\f\021\017 \030\026\r\017\r\001\017\b\f\016 \024\f\035\024\ \032\027\036\027\017\005 )Tj 0.309 Tw 23.244 23.138 Td (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\ \026\035\017\004\017\005 \n\036\032\007\031 \022\024\020\024\030\021\026\ )Tj 0 Tw (-)Tj 0.097 Tw T* (\n\017 \024\002\027\026\030\031\032\036\027\024 \027\036 \002\t\035\024.\ \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \023\030\017\n\036\030\027\ \024 )Tj -0.03 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\024\005 \004\026\f\021\024\021\024\005 \017\n\036\035\017\ \n\036\f\021\024 \024\f\035\024\032\027\036\027\017\016 I \017)Tj /Span<>> BDC ( )Tj EMC (II)Tj /Span<>> BDC ( )Tj EMC (\f\021\036)Tj 0 Tw (-)Tj 0.335 Tw T* [(\023\036\027\017 \(\023\024 \001\022\026\035\036 Cl)-16(av)-16(ien\226Dind)-15.9(o [10]\). \210\f\035\024\032\027\036\027\017\016 )]TJ -0.036 Tw T* (III)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017, \023\024\021\030\036\002\024\r\026\r\001\017\ \036 \023\024\r\021\024\030\027\t\b \r\n\036\001\026\021\036\035\034\f\021\ \r, )Tj 0.065 Tw T* (\030\026\r\017\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (2 \(3,6%\) \023\026\006\017\036\027\021\024\r \023\024\f\035\036 \f\036\020\ \n\036\027\021\026\030\027\t\b )Tj 0.09 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031 4 \(12,9%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\f\035\036 \030\026\f\001\017\030\036\027\027\t\b \024\023\036\ \030\026\006\017\005. \210\027\017 )Tj 0.691 Tw T* (\002\t\035\017 \023\030\036\007\f\021\026\r\035\036\027\t \027\036\f\024\ \f\021\024\016\021\036\035\034\027\024\f\021\034\033 \n\036\032\022\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026 \031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8%\) \023\026\006\017\036\027\021\026 \020\030\031\023\023\t \222\217\ )Tj -0.029 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023\023\t \217\217, \023\036\030\235\024\030\026\006\017\ \036\005 \021\024\027\022\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.007 Tw T* (\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2%\) \027\026\002\035\033\007\036\027\017\017 \023\024\f\035\036 \030\ \026\f\001\017\030\036\027\027\024\005 \030\036\036\022)Tj 0 Tw (-)Tj -0.049 Tw T* [(\006\017\017 \024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 10.054 0 Td (\021\026\022\032\036 \027\036\005\030\024\020\036\027\027\024\005 \007\017\ \f\235\031\027\022)Tj 0 Tw (-)Tj 0.293 Tw -10.054 -1.218 Td [(\006\017\036\005 \n\024\004\036\r\024\020\024 \023\031\t\030\016, )0.5(\023\024\021\030\036\002\024\r\026\r\001\036\005 \027\026\035\024\032\036\ \027\017\016 )]TJ -0.015 Tw T* (\220\023\017\006\017\f\021\024\f\021\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8%\) \f\035\031\004\026\036 \023\024\f\035\036 \f\036\020\n\036\027\021\ \026\030\027\024\005 )Tj -0.006 Tw T* (\030\036\036\022\006\017\017 \023\024\023\036\030\036\004\027\024\005 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017. \210\007\027\024 \ \(3,2%\) )Tj 0.119 Tw T* (\024\f\035\024\032\027\036\027\017\036 IV \f\021\036\023\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \217\217 \002\t\035\024 \023\030\036\007\f\021\026\ \r)Tj 0 Tw (-)Tj 0.057 Tw T* (\035\036\027\024 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \034\033 \n\036\032\022\017\001\036\004\027\024\020\024 \026\027\026\f\021\ \024\n\024\026 )Tj 0.286 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\r\017\r\001\017\n\f\016 \r\023\024\f\035\036\007\f\021\r\017\017\ )0.5(\026\002\007\024\n\017\027\026\035\034\027\t\n \f\036\023)]TJ 0 Tw (-)Tj 0.236 Tw T* (\f\017\f\024\n. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \035\036\021\026\035\034\027\024\f\021\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \026\030\036\020\017\f\021\030\017\030\024\r\ \026\027\024 \027\036 \002\t\035\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \031\033\027\032\020\ \006\022\235 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\031\b\031 \033\ \027\032\022\031\030\020 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29(i)-1.4(o)-4(n)3.7(s a)-5.1(n)-4.8(d t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(p)-9(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-2.8(v)2.3(e p)-11.3(e)-6(r)-39(i)-1.4(o)-12(d i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 715.181 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 346.0768 715.181 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 241.1949 694.1118 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 346.0768 694.1118 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 450.9586 694.1118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 663.4505 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 663.4505 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 663.4505 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 663.4505 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 651.9893 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 651.9893 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 651.9893 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 651.9893 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 640.528 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 241.1949 640.528 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 346.0768 640.528 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 450.9586 640.528 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 609.8667 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 609.8667 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 609.8667 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 609.8667 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 598.4054 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 598.4054 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 598.4054 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 598.4054 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 586.9441 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 586.9441 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 586.9441 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 586.9441 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 575.4828 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 241.1949 575.4828 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 575.4828 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 450.9586 575.4828 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 122.3426 701.7465 Tm (\200\004\006\004\214\r\003\006\013)Tj 16.254 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.326 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 9.838 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 10.962 0.6 Td (p)Tj /T1_1 1 Tf -53.244 -2.033 Td (\200\017\007 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \007\024\ \f\021\031\023\026)Tj 1.063 -1.2 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj -0 -1.2 Td (\210\021\022\030\t\021\t\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 28.112 1.2 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(69,1\))Tj T* (17)Tj /Span<>> BDC ( )Tj EMC (\(30,9\))Tj 13.11 1.2 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(67,7\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(32,3\))Tj 10.126 2.4 Td (1,0*)Tj -52.661 -3.833 Td (\025\030\024\r\024\023\024\021\036\030\016, \n\035 \204\036 \(Q1; Q3\))Tj 28.403 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(26,2; 50\))Tj 13.203 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(50; 100\))Tj 10.306 0 Td (0,02***)Tj -51.911 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017, \n\017\027 \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD\))Tj 28.586 0 Td (196,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (57,1)Tj 13.11 0 Td (192,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (60,2)Tj 10.465 0 Td (0,73**)Tj -52.161 -1.433 Td (\200\017\007 \026\027\026\f\021\024\n\024\026)Tj 1.063 -1.2 Td (\217\031\004\027\024\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj -0 -1.2 Td (\202\023\023\026\030\026\021\027\t\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 28.112 1.2 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(98,2\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 12.61 1.2 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(77,4\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(22,6\))Tj 9.626 2.4 Td (0,003*)Tj -52.161 -3.833 Td (\210\021\b\024\032\007\036\027\017\036 \023\036\030\r\t\b \020\026\024\r\ , \f\031\021\022\017 \204\036 \(Q1; Q3\))Tj 29.495 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1; 3\))Tj 13.11 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(2; 3\))Tj 9.306 0 Td (0,42***)Tj -51.911 -1.433 Td (\210\021\b\024\032\007\036\027\017\036 \023\036\030\r\024\020\024 \f\021\ \031\035\026, \f\031\021\022\017 \204\036 \(Q1; Q3\))Tj 29.495 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(3; 5\))Tj 13.11 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(2; 4\))Tj 9.306 0 Td (0,06***)Tj -51.911 -1.433 Td (\025\024\005\022\024-\007\036\027\034 \023\024\f\035\036 \024\023\036\030\ \026\006\017\017, \204\036 \(Q1; Q3\))Tj 29.245 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(6; 10\))Tj 13.11 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(7; 11\))Tj 9.556 0 Td (0,13***)Tj /T1_2 1 Tf 7 0 0 7 42.5197 563.9982 Tm (\004\032\022\026\027\007\020\025\022\027: \215)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \020\032\022\203\026\027\023\022\007\027\ \024\n\031\027, SD)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\020\025\030\020\032\023\025\031\027 \031\023\n\f\031\025\027\ \025\022\027, \215\027)Tj /Span<>> BDC ( )Tj EMC [(\227 \026\027\030\022\020\025)0.7(\020; Q1, Q3)]TJ /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD (t-\n\032\022\023\027\032\022\235 \205\023\017\005\030\027\025\023\020; *\ **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\027\024\023 \215\020\025\025\020\231\210)50.3(\022\023\025\022.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 536.2943 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \232\020\024\023\031\023\020 \022)Tj /Span<>> BDC ( )Tj EMC (\024\023\032\r\n\023\r\032\020 \033\031\024\f\027\031\033\027\032\020\006\ \022\031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235 \033\031\ )Tj /Span<>> BDC ( )Tj EMC 29.3 0 Td (\213\n\020\f\027 Clavien-Dindo \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw -29.3 -1.2 Td [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.318 0 Td [( F)29.2(r)-2(e)-9.4(q)-3(u)-3.2(e)-6.9(n)-2.9(c)-32.4(y a)-5.1(n)-4.8(d s)-14.8(t)-9.6(r)-9(u)-3.7(c)-32.4(t)-1.1(u)1.6(r)-2(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-9(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-2.9(v)2.3(e c)2.9(o)-4(m)-1(p)-4.9(li)-1.8(c)3.3(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-9.2(c)2.3(c)2.8(o)-3(r)-2.9(d)-3(i)3.9(n)-0.6(g t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e C)1.2(l)-1.1(a)-8.7(v)-32.5(i)-1.4(e)-7(n)-13.4(-)-14.3(D)-12.1(i)3.9(n)-4.8(d)-5.2(o sc)3.2(a)-4.5(le i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 520.9923 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 520.9923 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 346.0768 520.9923 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9587 520.9923 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 499.9231 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 241.1949 499.9231 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 346.0768 499.9231 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 450.9587 499.9231 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 469.2618 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 241.1949 469.2618 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 346.0768 469.2618 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 450.9587 469.2618 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 496.313 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 42.5197 419.4005 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 241.1949 419.4005 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 346.0768 419.4005 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 450.9587 419.4005 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 379.1392 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 379.1392 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 379.1392 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 379.1392 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 367.678 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 367.678 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 367.678 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 367.678 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 356.2167 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 356.2167 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 356.2167 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 356.2167 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 344.7554 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 241.1949 344.7554 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 344.7554 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 450.9587 344.7554 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 83.1589 507.5577 Tm (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\013\r \002\217\f\002\202\ \b\r\b\t\235)Tj 21.152 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.326 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 9.838 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 10.962 0.6 Td (p)Tj /T1_1 1 Tf -53.244 -2.033 Td (I \f\021\036\023\036\027\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\214\017\b\024\030\026\007\022\026)Tj 0 -1.2 TD (\206\036\n\026\021\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\005 \030\026\027\t)Tj 28.612 2.4 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,4\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(3,6\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 13.11 2.4 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj 9.876 2.4 Td (1,0*)Tj T* (1,0*)Tj T* (1,0*)Tj -52.661 -1.433 Td (II \f\021\036\023\036\027\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\210\f\021\030\t\005 \023\026\027\022\030\036\026\021\017\021)Tj T* (\215\026\030\036 \240\025\221)Tj T* (\025\035\024\f\021\030\017\007\017\026\035\034\027\t\005 \022\024\035\017\ \021)Tj T* (\233\r\036\027\021\030\026\006\017\016)Tj 28.362 4.8 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10,9\))Tj 1.329 -1.2 Td (0)Tj -1.079 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,4\))Tj 1.079 -1.2 Td (0)Tj -1.079 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 12.86 4.8 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(19,3\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(3,4\))Tj 1.079 -1.2 Td (0)Tj 8.547 4.8 Td (0,34*)Tj T* (0,36*)Tj 0.25 -1.2 Td (1,0*)Tj T* (1,0*)Tj T* (1,0*)Tj -52.661 -1.433 Td (III \f\021\036\023\036\027\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \026\027\026\ \f\021\024\n\024\026)Tj T* (\215\036\030\235\024\030\026\006\017\016 \021\024\027\022\024\005 \022\017\ \001\022\017)Tj T* (\203\036\005\030\024\020\036\027\027\026\016 \007\017\f\235\031\027\022\006\ \017\016 \n\024\004\036\r\024\020\024 \023\031\t\030\016)Tj 28.612 3.6 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,6\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 1.079 -1.2 Td (0)Tj -1.079 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 12.86 3.6 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(12,9\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj 1.079 -1.2 Td (0)Tj 8.547 3.6 Td (0,18*)Tj T* (0,11*)Tj T* (0,36*)Tj 0.25 -1.2 Td (1,0*)Tj -52.661 -1.433 Td (IV \f\021\036\023\036\027\034 \(\222\036\023\f\017\f\), )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 30.754 0 Td (0)Tj 12.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj 9.626 0 Td (0,36*)Tj -52.411 -1.433 Td (V \f\021\036\023\036\027\034)Tj 30.754 0 Td (0)Tj 13.11 0 Td (0)Tj 9.362 0 Td (\226)Tj -53.226 -1.433 Td (\232\026\f\021\024\021\026 \024\f\035\024\032\027\036\027\017\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 29.175 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(20,0\))Tj 13.11 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(41,9\))Tj 10.126 0 Td (0,04*)Tj /T1_2 1 Tf 7 0 0 7 42.5197 333.2707 Tm (\004\032\022\026\027\007\020\025\022\027: *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (129)Tj ET endstream endobj 747 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.165 Tw 10 0 0 10 70.8661 542.1599 Tm (\023\030\026\r\007\024\023\024\007\024\002\017\016 \(LR)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (10\), \021\036\f\021\026 \216\024\f\n\036\030\026\226\214\036\n\036\001\024\ \r\026 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf -0.028 Tw /Span<>> BDC ( )Tj EMC 1.052 0 Td (>)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(0,05\), )0.5(R)]TJ 0 Tw 5.83 0 0 5.83 118.151 533.3119 Tm (2)Tj -0.028 Tw 10 0 0 10 121.066 529.9819 Tm [( )0.5(\204\026\022\235\026\007\007\036\027\026. )0.6(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\027\026\004\017\n\024\f\021\034 )]TJ 0.044 Tw -5.02 -1.218 Td (\023\030\017\027\017\n\026\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \210\002\030\026\002\024\021\022\026 \007\026\027\027\t\b \r\t\023\ \024\035)Tj 0 Tw (-)Tj T* (\027\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC [(G)20.1(r)-33(aphP)40(adP)35(r)-37(is)26(m v.10 \(\222\231\202\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 469.0919 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.372 Tw 10 0 0 10 70.8661 444.7359 Tm [(\206\030\031\023\023\t )0.5(\002\t\035\017 )0.6(\f\024\023\024\f\021\026\r\017\n\t)]TJ /Span<>> BDC ( )Tj EMC 12.325 0 Td [(\227 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 3.21 0 Td [(\023\024\035\031, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.789 0 Td (\020\030\031\023\023\036 )Tj 0.202 Tw -19.324 -1.218 Td (\222\217 \n\031\032\004\017\027 \002\t\035\024 23)Tj /Span<>> BDC ( )Tj EMC (\(41,8%\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \217\217)Tj /Span<>> BDC ( )Tj EMC (\227 10)Tj /Span<>> BDC ( )Tj EMC (\(32,3%\) )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.08 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,36\). \221\026\022\032\036 \027\036 \024\021\n\036\004\036\027\024 \030\ \026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\036\007\036)Tj 0 Tw (-)Tj 0.084 Tw T* (\035\036\027\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\031: \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \222\217 \f\030\036\007\027\017\005 \r\024\030\ \026\f\021 \f\024)Tj 0 Tw (-)Tj 0.04 Tw T* (\f\021\026\r\017\035 65,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (11,7 \035\036\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \217\217)Tj /Span<>> BDC ( )Tj EMC (\227 69,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,9 \035\036\021 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.046 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07\). \230\027\007\036\022\f \n\026\f\f\t \021\036\035\026 \(\230\204\221\ \) \002\t\035 \f\024\023\024\f\021\026\r\017\n )Tj 0.234 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\235\024\030\n\017\030\024\r\026\027\027\t\b \r\t\002\024\030\022\026\b\ , \036\020\024 \n\036\007\017\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.443 Tw T* (\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022\006\ \017\017 \f\024\f\021\026\r\017\035\026 28,1 \(25,1; )Tj 0.273 Tw T* (30,6\) \022\020/\n)Tj 0 Tw 5.83 0 0 5.83 114.9287 350.6418 Tm (2)Tj 0.273 Tw 10 0 0 10 117.8437 347.3119 Tm (, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.296 Tw -4.698 -1.218 Td (26,0 \(23,9; 27,7\) \022\020/\n)Tj 0 Tw 5.83 0 0 5.83 166.2453 338.4639 Tm (2)Tj 0.296 Tw 10 0 0 10 169.1603 335.1339 Tm (, \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.296 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\). \217\026\f\023\030\036\007\036\035\036\027\017\036 )Tj 0.179 Tw 13.415 20.703 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\026\n \026\027\036\f\021\036\017\024\035\024\020\017\004\ \036\f\022\024\020\024 \030\017\f\022\026 A)35(SA \(I-III\) )]TJ T* (\021\026\022\032\036 \027\036 \030\026\035\017\004\026\035\024\f\034 \(\ )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.179 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,58\). \210\007\027\026\022\024 \023\026\006\017\036\027\021\t )Tj -0.006 Tw T* (\020\030\031\023\023\t \217\217 \017\n\036\035\017 \002\024\035\036\036 \ \r\t\f\024\022\017\005 \017\027\007\036\022\f \022\024\n\024\030\002\017\ \007\027\024)Tj 0 Tw (-)Tj -0.002 Tw T* (\f\021\017 \232\026\030\035\f\024\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 8,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,4 \002\026\035\035\024\r \023\030\024\021\017\r 6,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,7)Tj /Span<>> BDC ( )Tj EMC (\002\026\035)Tj 0 Tw (-)Tj T* (\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \222\217 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.247 Tw T* (\215\030\017 \r\t\023\024\035\027\036\027\017\017 \024\023\036\030\026\006\ \017\005 \023\030\036\024\002\035\026\007\026\035 \035\026\023\026\030\024\ \f\022\024)Tj 0 Tw (-)Tj 0.007 Tw T* (\023\017\004\036\f\022\017\005 \007\024\f\021\031\023, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\ \036\036\022\006\017\017 \024\027 )Tj 0.037 Tw T* (\002\t\035 \023\030\017\n\036\027\036\027 \031)Tj /Span<>> BDC ( )Tj EMC (38/55 \(69,1%\) \023\026\006\017\036\027\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 )Tj 0.062 Tw T* (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (21/31 \(67,7%\) \002\024\035\034\027\024\020\024 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.05 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\ \006\017\005 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026)Tj 0 Tw (-)Tj 0.18 Tw T* (\004\017\n\024 \027\036 \030\026\035\017\004\026\035\026\f\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 196,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (57,1)Tj /Span<>> BDC ( )Tj EMC (\n\017\027 )Tj 0.242 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.949 0 Td [(\020\030\031\023\023\036 )0.5(\222\217 )0.5(\023\030\024\021\017\r )0.5(192,3)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC 11.697 0 Td [(60,2 )0.5(\n\017\027 \r)]TJ /Span<>> BDC ( )Tj EMC 5.183 0 Td [(\020\030\031\023\023\036 )0.5(\217\217 )]TJ 0 Tw -17.828 -1.218 Td (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.251 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,73\). \204\036\007\017\026\027\026 \022\030\024\r\024\023\024\021\036\030\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b )Tj -0.017 Tw T* (\002\t\035\026 \n\017\027\017\n\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 50 \n\035. \217\026\035\017\004\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.001 Tw T* [(\007\017\026\027\027\t\b )0.6(\027\026\004\036\027\017\016\b )0.6(\024\002\255\036\n\026 )0.5(\022\030\024\r\024\023\024\021\036\030\017 )0.5(\n\036\032\007\031 )0.6(\020\030\031\023)]TJ 0 Tw (-)Tj 0.11 Tw T* (\023\026\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n \002\t\035\017 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 \()]TJ /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.11 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,02\), \027\024 )0.5(\027\036 )]TJ 0.107 Tw T* [(\022\035\017\027\017\004\036\f\022\017 \027\026\004\017\n\t. )0.5(\204\036\032\022\017\001\036\004\027\t\005 \026\027\026\f\021\024\n\024\ \030\031\004)]TJ 0 Tw (-)Tj 0.062 Tw T* (\027\t\n \f\023\024\f\024\002\024\n \004\026\013\036 \235\024\030\n\017\030\ \024\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\n\036\027\021\026\030\027\024\005 )Tj ET q 70.866 100.97 345.827 215.937 re W n q /GS0 gs 345.8267624 0 0 215.9917297 70.8661499 100.9151917 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \221\f\031\n-\024\200\027\026\020 \022\024\024\f\027\030\031\021\020\025\ \022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(esearch scheme)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \b\032\r\033\033 \033\ \020\006\022\027\025\023\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 3.324 0 Td [( C)0.9(h)2.4(a)-2.2(r)5.3(a)-7.2(c)-30.3(te)-4(r)-37(i)8.6(s)-12.8(t)-27.1(ic)-24.7(s)2( o)6.1(f)]TJ /Span<>> BDC 7.087 0 Td ( )Tj EMC [(p)-4.3(a)-7.2(t)-27.1(i)0.7(e)-5.1(n)1.5(t)2( g)0.5(ro)-1.4(up)3.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 252.5335 715.181 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 360.25 715.181 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 467.9666 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 252.5335 694.1118 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 360.25 694.1118 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 467.9666 694.1118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 663.4504 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 663.4504 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 663.4504 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 663.4504 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 651.9892 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 651.9892 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 651.9892 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 651.9892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 640.5279 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 252.5335 640.5279 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 360.25 640.5279 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 467.9666 640.5279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 600.2666 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 600.2666 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 600.2666 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 600.2666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 588.8054 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 252.5335 588.8054 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 588.8054 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 467.9666 588.8054 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 142.1851 701.7464 Tm (\200\004\006\004\214\r\003\006\013)Tj 15.368 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.326 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 10.193 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 11.848 0.6 Td (p)Tj /T1_0 1 Tf -52.536 -2.033 Td (\215\024\035, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\204\031\032\f\022\024\005)Tj T* (\240\036\027\f\022\017\005)Tj 26.163 1.2 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(41,8\))Tj T* (32)Tj /Span<>> BDC ( )Tj EMC (\(58,2\))Tj 13.465 1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(32,3\))Tj T* (21)Tj /Span<>> BDC ( )Tj EMC (\(67,7\))Tj 11.012 2.4 Td (0,49*)Tj -51.703 -3.833 Td (\200\024\030\026\f\021, \035\036\021 \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD\))Tj 27.23 0 Td (65)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (11,7)Tj 13.372 0 Td (69,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,9)Tj 10.851 0 Td (0,07**)Tj -51.453 -1.433 Td (\230\027\007\036\022\f \n\026\f\f\t \021\036\035\026, \022\020/\n\262 \204\ \036 \(Q1; Q3\))Tj 25.769 0 Td (28,1)Tj /Span<>> BDC ( )Tj EMC (\(25,1; 30,6\))Tj 13.807 0 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(23,9; 27,7\))Tj 11.627 0 Td (0,13***)Tj -51.203 -1.433 Td (\025\035\026\f\f \023\024 \001\022\026\035\036 ASA, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (ASA I)Tj 0 -1.2 TD (ASA II)Tj 0 -1.2 TD (ASA III)Tj 26.663 2.4 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,1\))Tj -0.5 -1.2 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(47,3\))Tj T* (24)Tj /Span<>> BDC ( )Tj EMC (\(43,6\))Tj 13.965 2.4 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj -0.5 -1.2 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(48,4\))Tj T* (15)Tj /Span<>> BDC ( )Tj EMC (\(48,4\))Tj 10.262 3.6 Td (0,58****)Tj -50.953 -5.033 Td (\230\027\007\036\022\f \022\024\n\024\030\002\017\007\027\024\f\021\017 \ \232\026\030\035\f\024\027\026 \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD\))Tj 27.387 0 Td (6,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,7)Tj 13.465 0 Td (8,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,4)Tj 10.601 0 Td (0,03**)Tj /T1_1 1 Tf 7 0 0 7 70.8661 577.3207 Tm (\004\032\022\026\027\007\020\025\022\027: \215)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \020\032\022\203\026\027\023\022\007\027\ \024\n\031\027, SD)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\020\025\030\020\032\023\025\031\027 \031\023\n\f\031\025\027\ \025\022\027, \215\027)Tj /Span<>> BDC ( )Tj EMC [(\227 \026\027\030\022\020\025)0.7(\020; Q1, Q3)]TJ /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD (t-\n\032\022\023\027\032\022\235 \205\023\017\005\030\027\025\023\020; *\ **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\027\024\023 \215\020\025\025\020\231\210)50.3(\022\023\025\022; ****)]TJ /Span<>> BDC ( )Tj EMC (\227 \250)Tj 4.081 0 0 4.081 253.8083 571.2516 Tm (2)Tj 7 0 0 7 255.8488 568.9207 Tm ( \004\022\032\024\031\025\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 20.7902 56.0378 Tm (128)Tj ET endstream endobj 748 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;Z   V#!1"AQRUa2ST#Bq$34b %&'()*56789:CDEFGHIJVWXYZcdefghijrstuvwxyz?QеQcp!1P8`pL>F=ϐtms+{GNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O9kԫaEf6nvZB9ܭov!N.,q+{ÚZátݭZ'b!p|Y6KL6jVy-llHQ>N-xiWOńqB[S״ev:#c%j\K3VϧZ, Y9͉f@.!mǵ$N*fV =I3˴HIu݇9>ڊ= ۗbK%x7z?4DGK>` o! wv+F_ 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RZ;5h$oksO dݯJN>!ݯJN>!ݯJN>!ݯJZ0x5Cf'F8f8!DMOzKH,JT8hyr ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJ\%7 {L"dԱuK#X\I9M$EZ@M.S̴G9YfˆmtGeXf;^ #: c q B ndySC3c5k1[A TfHɔO夞nnt {gYA4#4Qhm} C8+J59 GG 9F[4Ay:Hi+uW>; 5F4:\.p >嚍I%u1#nlb&[ ioGRwܒ[*5eh49獡Iic v>DU23!e+z1AȭVyQ$Nuwds7̘xlXdv0ޮ fEpk^ִFsA O y^颚S;ۘldc^pA bfs,}{08#%x07>+*٪l e$֦Yk|Fhef9;0ANnoWIۊ>e+0N4vLˏ9-T- b^,] h7ś`fb !&ؘpXG\'HrhcF9oz6֗O"\r Ï3chdut (z{'(z{'(z{'(z{'(z{'(z{/cfn[(#?C Ef$`n̴ὡe:{ U؞+q'Ǽu+;,#%mr7r7r7r7r7r7r7r7r7r7r7Ç!vB0k f, oXx8s)DDDDDDDDDDDDDDDDDDDDDֵQ׵Q endstream endobj 751 0 obj <>stream endstream endobj 746 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.017 Tw 10 0 0 10 42.5197 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\f\035\036\007\027\017\036 \024\002\036\f\023\036\004\017\r\ \026\033\021 \031\007\026\035\036\027\017\036 \002\024\035\034)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\001\036\020\024 \022\024\035\017\004\036\f\021\r\026 \035\017\n\235\026\ \021\017\004\036\f\022\017\b \031\035\024\r \017, \021\036\024\030\036\021\ \017\004\036)Tj 0 Tw (-)Tj 0.188 Tw T* (\f\022\017, \n\024\020\031\021 \002\t\021\034 \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\n \030\026\007\017\022\026\035\017\n\024\n. )Tj 0.06 Tw T* (\203\024, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024, )0.5(\004\026\f\021\024\021\026 \023\024\030\026\032\036\027\017\016 )0.5(\035\017\n\235\024\031\035\024\r )]TJ 0.123 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \024\002\024\017\b \021\017\023\024\ \r \r\n\036\001\026\021\036\035\034\f\021\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.127 Tw T* (\027\t\n Guan X. \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\ \004\017\n\024 \027\036 \030\026\035\017\004\026\035\026\f\034 )Tj 0.083 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 34% \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.083 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,985\) [6]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 )Tj 0.104 Tw 0 -1.218 TD (\024\023\031\002\035\017\022\024\r\026\027\t \030\026\002\024\021\t, \f\030\ \026\r\027\017\r\026\033\013\017\036 \f\036\020\n\036\027\021\026\030\027\ \031\033 )Tj 0.279 Tw T* (\030\036\036\022\006\017\033 \023\024\023\036\030\036\004\027\024\005 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017)Tj 0 Tw (-)Tj 0.389 Tw T* (\030\036\027\027\031\033 \023\030\026\r\024\f\021\024\030\024\027\027\033\ \033 \020\036\n\017\022\024\035\220\022\021\024\n\017\033, \017\b \030\036\ )Tj 0 Tw (-)Tj 0.05 Tw T* [(\031\035\034\021\026\021\t \023\030\024\021\017\r\024\030\036\004\017\r\ \t. Mil)30.1(one e)-12(t al. \(2020\) \023\030\024\007\036)]TJ 0 Tw (-)Tj 0.07 Tw T* (\n\024\027\f\021\030\017\030\024\r\026\035 \023\030\036\017\n\031\013\036\ \f\021\r\026 \030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\ \006\017\017 )Tj 0.093 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 \f\027\017\032\036\027\017\016 )0.5(\004\026\f\021\024\021\t \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\b )]TJ -0.022 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (30,1% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\t\b \030\036\ \036\022\006\017\005 )Tj 0.042 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (23,6% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\t\b \030\036\ \036\022\006\017\005 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.042 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\). )Tj 0.55 Tw T* (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \026\027\026\ \f\021\024\n\024\026 \004\026\013\036 \030\026\r\017\r\026\035\026\f\034\ )Tj 0.167 Tw T* (\023\024\f\035\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\036\ \036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 4,4% \023\030\024\021\017\r 2,2% )Tj 0.063 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \217\217 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.063 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \221\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 )Tj 0.53 Tw T* [(\030\036\036\022\006\017\017 )0.5(3-\035\036\021\027\016\016 )0.5(\002\036\030\036\006\017\007\017\r\027\026\016 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )]TJ 0.282 Tw T* (\002\t\035\026 \027\017\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 78,1% \023\030\024\021\017\r 86,2% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f)Tj 0 Tw (-)Tj 0.21 Tw T* (\001\017\030\036\027\027\t\b \024\023\036\030\026\006\017\005 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.21 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) [7]. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, )Tj 0.26 Tw T* [(M)-24(or)-33(ar)-32.9(asu)]TJ /Span<>> BDC ( )Tj EMC (S. \(2021\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\n \n\036\021\026\026\027\026\035\017\036 \027\036 \024\002\ \027\026)Tj 0 Tw (-)Tj 0.214 Tw T* [(\030\031\032\017\035 )0.5(\027\026\004\017\n\t\b )0.6(\030\026\035\017\004\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.769 0 Td [(\r\036\030\024\016\021\027\024\f\021\017 )0.6(\030\026\r\017\021\017\016 )]TJ 0.176 Tw -12.769 -1.218 Td [(\030\036\006\017\007\017\r\026 )0.5(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 6.504 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td [(0,88; )0.5(95% )0.6(\212\230 )0.5(0,59\2261,34; )]TJ /T1_2 1 Tf 0 Tw 10.848 0 Td (\032)Tj /T1_1 1 Tf 0.176 Tw /Span<>> BDC ( )Tj EMC 0.886 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td (0,56\) )Tj 0.172 Tw -20.055 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \024\002\013\036\005 \r\t\032\017\ \r\026\036\n\024\f\021\017 \n\036\032\007\031 \020\030\031\023\023\026)Tj 0 Tw (-)Tj 0.027 Tw T* (\n\017 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,98; 95% \212\230 0,68\2261,4; )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.027 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,9\) [8]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 )Tj 0.08 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \027\026\n\017 \002\t\035\024 \023\030\024\r\036\007\036\027\ \024 \f\030\026\r\027\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r )Tj 0.37 Tw T* (\f\036\020\n\036\027\021\026\030\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0 Tw T* (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 347.3118 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.082 Tw 10 0 0 10 42.5197 322.9558 Tm [(\222\030\026\r\027\017\021\034 \027\036\023\024\f\030\036\007\f\021\r\036\ \027\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\021\t \f\036\020\n\036\027\021\026\030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\b \030\036\036\022\006\017\005 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0 Tw T* (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 262.0658 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.097 Tw 10 0 0 10 42.5197 237.7098 Tm [(\215\030\024\r\036\007\036\027 )0.5(\030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 )0.6(\026\027\026\035\017 )0.6(\002\026\t )0.5(\007\026\027\027\t\b )0.5(\002\024\035\034)]TJ 0 Tw (-)Tj 0.268 Tw T* (\027\t\b, \023\036\030\036\027\036\f\001\017\b \023\035\026\027\024\r\024\ \036 \b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\ \017\036 )Tj 0.167 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \f\030\036\007\027\036\005 \021\030\ \036\021\017 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\ \004)Tj 0 Tw (-)Tj -0.006 Tw T* (\027\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\016 2017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\034 2023 \020\020. )Tj 0.019 Tw T* [(\221\026\022\017\b )0.5(\023\026\006\017\036\027\021\024\r )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 8.313 0 Td [(6 )0.5(\035\036\021 )0.5(\024\022\026\026\035\024\f\034 )0.6(101. )0.5(\025\030\017\021\036\030\017\016\n\017 )]TJ 0.758 Tw -8.313 -1.218 Td (\027\036\r\022\035\033\004\036\027\017\016 \016\r\035\016\035\017\f\034 \ \023\036\030\r\017\004\027\024-\n\027\024\032\036\f\021\r\036\027\027\t\036\ )Tj 0.342 Tw T* (\035\024\022\026\004\036\f\021\r\036\027\027\t\036 \027\024\r\024\024\002\ \030\026\024\r\026\027\017\016 \(\031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b\), )Tj 0.108 Tw T* (\f\036\n\036\005\027\t\005 \026\007\036\027\024\n\026\021\024 \021\024\035\ \f\021\024\005 \022\017\001\022\017 \(\031)Tj /Span<>> BDC ( )Tj EMC (2 \002\024\035\034\027\t\b\), )Tj 0.164 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\036 \026\002\024\035\036\ \r\026\027\017\016 \022\017\001\036\004\027\017\022\026 \(\031 2 \002\024\ \035\034)Tj 0 Tw (-)Tj 0.275 Tw T* (\027\t\b\), \024\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\ \t \(\031)Tj /Span<>> BDC ( )Tj EMC (8)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b\). \200)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.359 Tw T* (\031\035\034\021\026\021\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \002\t\035\024 \r\022\035\033\004\036\027\024 86 \023\ \026\006\017\036\027\021\024\r. )Tj 0.224 Tw T* (\214\024\022\026\035\017\026\006\017\016 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 )Tj 0.182 Tw T* (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \031\f\021\026\ \027\026\r\035\017\r\026\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\023\026\007\036\027\017\017 )Tj 0.43 Tw T* (\007\026\027\027\t\b \022\024\035\024\027\024\f\022\024\023\017\017, \022\ \024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\235\ \017\017 )Tj -0.001 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \030\ \036\r\017\017\017. \210\002\255\036\n \b\017\030\031\030\020\017\004\036\ \f\022\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\024 \035\036\004\036\027\017\016 \024\023\030\036\007\036\035\016\035\ \f\016 \024\023\036\030\017\030\031\033\013\017\n \b\017\030\031\030\020\ \024\n.)Tj 0.383 Tw 0 -1.218 TD (\207\t\035\026 \023\030\024\r\036\007\036\027\026 \024\006\036\027\022\026\ \f\035\036\007\031\033\013\017\b \007\026\027\027\t\b: \023\024\035, )Tj 0.307 Tw 0 -1.218 TD (\r\024\030\026\f\021, \017\027\007\036\022\f \n\026\f\f\t \021\036\035\026\ , \022\035\026\f\f \026\027\036\f\021\036\017\024\035\024\020\017)Tj 0 Tw (-)Tj 0.097 Tw T* (\004\036\f\022\024\020\024 \030\017\f\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 A)35(SA, \017\027\007\036\022\f \022\024\n\024\030\002\017\007\027\024\f\021\017\ )]TJ 0.037 Tw T* (\232\026\030\035\f\024\027\026, \r\017\007 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 \007\024\f\021\031\023\026, \024\002\255\036\n \017\ \027\021\030\026)Tj 0 Tw (-)Tj 0.081 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\024\027\027\024\005 \022\030\024\r\024\023\024\ \021\036\030\017, \007\035\017\021\036\035\034\027\024\f\021\034 \024\023\ \036\030\026\006\017\017, )Tj 0.059 Tw 0 -1.218 TD [(\r\017\007 )0.5(\026\027\026\f\021\024\n\024\026, \r\030\036\n\016 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\020\024 )0.5(\024\021\b\024\032\007\036\027\017\016 )0.5(\020\026\024\r )]TJ 0.134 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\031\035\026, \004\026\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj -0.023 Tw T* (\035\024\032\027\036\027\017\005, \022\024\035\017\004\036\f\021\r\024 \031\ \007\026\035\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\027\t\b \035\017\n)Tj 0 Tw (-)Tj 0.153 Tw T* (\235\026\021\017\004\036\f\022\017\b \031\035\024\r, \f\021\026\007\017\ \016 pTNM, \004\026\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030 )Tj 0.401 Tw T* [(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016, )0.6(\235\026\022\021 )0.5(\023\030\024\r\036\007\036\027\017\016 )0.6(\026\007\255\033\r\026\027\021\027\024\005 )]TJ 0.029 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (5-\035\036\021\027\016\016 \024\002\013\026\016 \r\t\032\017\r\026\036\n\ \024\f\021\034 \(\210\200\). )Tj -0.017 Tw T* (\221\026\022\032\036 \n\036\021\024\007\024\n \024\023\030\024\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \f\030\024\022\017 \017\031\004\026\ \035\026\f\034 )Tj 0.08 Tw T* (\022\030\026\021\027\024\f\021\034 \f\021\031\035\026, \021\017\023 \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\017\f\021\036\027\006\017\016 \022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\024\005 [9\ ].)Tj -0.041 Tw T* (\200 \026\r\017\f\017\n\024\f\021\017 \024\021 \023\030\024\r\036\007\036\ \027\027\024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\ \036\001\026)Tj 0 Tw (-)Tj T* (\021\036\035\034\f\021\r\026 \002\024\035\034\027\t\036 \002\t\035\017 \030\ \026\007\036\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \020\030\031\023\023\t:)Tj 0.199 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \023\026\006\017\036\ \027\021\026\n \r\t\023\024\035\027\016\035\026\f\034 \f\036\020)Tj 0 Tw (-)Tj 0.238 Tw -1.296 -1.218 Td (\n\036\027\021\026\030\027\026\016 \030\036\036\022\006\017\016 \023\024\ \023\036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017 )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \023\030\024\r\024\007\017\035\024\f\034 \031\ \007\026\035\036\027\017\036 \035\017\n\235\024)Tj 0 Tw (-)Tj 0.18 Tw T* (\031\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\002\026\f\f\036\005\027\036 \f\030\036\007\027\036\005 \024\002\024\007\ \024\004\027\024\005 \026\030\021\036\030\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\036\036 )Tj 0.017 Tw T* (\023\036\030\036\r\016\022\024\005 \031)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\016. \204\024\002\017\035\017\026\006\017\016\ \023\030\026\r\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tw (-)Tj -0.04 Tw T* [(\r\024\020\024 \017\020\017\002\024\r \024\002\024\007\024\004\027\024\005\ )0.5(\022\017\001\022\017 \r\t\023\024\035\027\016\035\026\f\034 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 19.805 0 Td (\031\f\n\024)Tj 0 Tw (-)Tj -19.805 -1.218 Td (\021\030\036\027\017\033 \b\017\030\031\030\020\026.)Tj 0.107 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \023\030\024\017\ \r\024\007\017\035\026\f\034 \030\026\f\001\017\030\036\027\027\026\016\ )Tj 0.234 Tw -1.296 -1.218 Td (\023\030\026\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\ \035\220\022\021\024\n\017\016 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.234 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\) \f)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\027\017\036\n \035\017\n\235\024\031\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \f\030\036\007\027\017\b \024\002\024\007\024\004\027\t\b\ , \023\024\007)Tj 0 Tw (-)Tj T* (\r\007\024\001\027\024-\024\002\024\007\024\004\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\002\024\007\024\004\027\t\b \f\024\f\031\007\024\ \r.)Tj /T1_4 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.332 Tw 0 -1.218 TD (\215\030\024\r\036\030\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\024\036 \030\026\f\023\030\036\007\036\035\ \036\027\017\036 \024\f\031\013\036\f\021)Tj 0 Tw (-)Tj 0.109 Tw T* (\r\035\016\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \022\030\017\021\036\030\017\016 \212\241\202\020\ \024\f\021\017\027\026\226\215\017\030\f\024\027\026. )Tj 0.371 Tw T* (\025\024\035\017\004\036\f\021\r\036\027\027\t\036 \r\036\035\017\004\017\ \027\t \024\023\017\f\t\r\026\035\017\f\034 \f\030\036\007\027\017\n\017\ )Tj -0.022 Tw T* (\027\026\004\036\027\017\016\n\017 \(\204\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\t\n\017 \024\021\022\035\024\027\036\027\ \017\016\n\017 \(\261)Tj /Span<>> BDC ( )Tj EMC (SD\) )Tj 0.484 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \206\026\031\f\f\024\r\026 \030\026\f\023\030\036\ \007\036\035\036\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034)Tj 0 Tw (-)Tj 0.298 Tw T* (\027\t\b \f\035\031\004\026\016\b \007\026\027\027\t\036 \023\030\036\007\ \f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \n\036\007\017\026)Tj 0 Tw (-)Tj 0.255 Tw T* (\027\t \(\204\036\), \027\017\032\027\036\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\036\020\024 \022\r\026\030\021\017\035\036\005 \(Q1; Q3\ \). )Tj 0.05 Tw T* (\222\030\026\r\027\036\027\017\036 \020\030\031\023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \r\036\035\017\004\017\027\026\n \024\f\031\013\036\f\021\ \r\035\016\035\024\f\034 )Tj 0.395 Tw T* (t-\022\030\017\021\036\030\017\036\n \222\021\034\033\007\036\027\021\026\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \027\024\030\n\026\035\034\027\024\020\024 )Tj 0.146 Tw T* [(\030\026\f\023\030\036\007\036\035\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.552 0 Td [(U-\022\030\017\021\036\030\017\036\n )0.6(\204\026\027\027\026\226\211\017\021\027\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.58 0 Td (\027\036 )Tj 0.292 Tw -21.132 -1.218 Td (\206\026\031\f\f\024\r\024\n \030\026\f\023\030\036\007\036\035\036\027\017\ \017. \232\036\021\t\030\036\b\023\024\035\034\027\t\036 \021\026\002\035\ \017)Tj 0 Tw (-)Tj 0.536 Tw T* (\006\t \026\027\026\035\017\017\030\024\r\026\035\017\f\034 \007\r\031\f\ \021\024\030\024\027\027\017\n \021\024\004\027\t\n \022\030\017)Tj 0 Tw (-)Tj 0.233 Tw T* [(\021\036\030\017\036\n \205\017\001\036\030\026; )0.5(\n\027\024\020\024\023\024\035\034\027\t\036)]TJ /Span<>> BDC ( )Tj EMC 13.829 0 Td [(\227 \245\262 )0.5(\215\017\030\f\024\027\026 \r\027\036 )]TJ 0.304 Tw -13.829 -1.218 Td (\026\r\017\f\017\n\024\f\021\017 \024\021 \024\032\017\007\026\036\n\t\b\ \027\026\004\036\027\017\005. \202\027\026\035\017 \r\t)Tj 0 Tw (-)Tj 0.239 Tw T* (\032\017\r\026\036\n\024\f\021\017 \023\030\024\017\r\024\007\017\035\026\ \f\034 \023\031\021\036\n \023\024\f\021\030\024\036\027\017\016 \022\030\ \017)Tj 0 Tw (-)Tj 0.16 Tw T* (\r\t\b \025\026\023\035\026\027\026\226\204\036\005\036\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\024\020-\030\026\027\020\024\ \r\024\020\024 )Tj 0.281 Tw T* (\021\036\f\021\026 \007\035\016 \f\030\026\r\027\036\027\017\016. \212\035\ \016 \r\t\016\r\035\036\027\017\016 \023\030\036\007\017\022\021\024\030\ \024\r )Tj 0.13 Tw T* (\017\f\b\024\007\024\r \023\030\017\n\036\027\016\035\026\f\034 \023\030\ \024\f\021\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\036\027\027\026\016 \002\017)Tj 0 Tw (-)Tj 0.046 Tw T* (\027\026\030\027\026\016 \035\024\020\017\f\021\017\004\036\f\022\026\016\ \030\036\020\030\036\f\f\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\024\n \024\021\027\024\001\036)Tj 0 Tw (-)Tj 0.153 Tw T* [(\027\017\016 )0.5(\001\026\027\f\024\r \(\210\231\) \017)]TJ /Span<>> BDC ( )Tj EMC 8.728 0 Td [(95% \007\024\r\036\030\017\021\036\035\034\027\024\020\024 )0.5(\017\027\021\036\030\r\026\035\026 )]TJ 0.318 Tw -8.728 -1.218 Td (\(\212\230\). \200)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017\r\026\030\017\026\027\021\027\031\033 \n\024\007\036\ \035\034 \r\022\035\033\004\026\035\017 \023\030\036)Tj 0 Tw (-)Tj 0.036 Tw T* (\007\017\022\021\024\030\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.036 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,1 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\r\026\030\017\026\027\021\027\024\n \026\027\026\035\017\036\ ; \022\026)Tj 0 Tw (-)Tj 0.164 Tw T* [(\004\036\f\021\r\024 )0.5(\n\024\007\036\035\017 )0.6(\024\006\036\027\017\r\026\035\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.775 0 Td [(\027\026\004\036\027\017\016\n )0.6(\024\021\027\024\001\036\027\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.552 56.0378 Tm (127)Tj ET endstream endobj 745 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 480.8534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 480.8534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 443.6456 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 443.6456 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 389.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.104 Tw 9 0 0 9 119.0551 730.4919 Tm [(AIM: )0.5(to )0.5(com)16(pare )0.5(early )0.5(and )0.6(late )0.5(results )0.5(af)-45.9(ter )0.5(segmental )0.6(and )0.5(e)-15(xtended )0.5(resections )0.5(in )0.5(middle )0.5(third )0.5(transv)13(erse )0.5(colon )]TJ 0 Tw 0 -1.111 TD [(cancer)51.1(.)]TJ 0.186 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a retrospectiv)13(e study included 86 patients with middle third transv)13(erse colon cancer )]TJ 0.073 Tw T* [(who under)-32(w)12(ent resection betw)12.1(een 2017\2312023. P)18(atients w)12(ere divided into segmental resection \(SR\) \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\) and )Tj 0.098 Tw T* [(e)-15(xtended colectom)11.1(y \(EC\) \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(31\) g)14(roups. Intraoperativ)13.1(e parameters, incidence, nature of postoperativ)13(e morbid)]TJ 0 Tw (-)Tj 0.05 Tw 0 -1.111 TD [(ity and histopathological f)-43(indings w)12(ere ev)16(aluated. Late outcomes and functional results w)12.1(ere analysed. S)28(tatistical )]TJ 0.023 Tw 0 -1.111 TD [(analysis included reg)14(ression models to identify com)16(plication p)46(redictors.)]TJ 0.125 Tw T* [(RESUL)30(T)-10(S: postoperativ)13(e com)16(plications in the CP g)14(roup w)12(ere low)12(er than af)-46(ter e)-15(xtended surg)11.9(er)-43(y)]TJ /Span<>> BDC ( )Tj EMC (\227 11/55 \(20%\) )Tj -0.003 Tw T* [(v)13(ersus 13/31 \(41.9%\) cases \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.04\). In multiv)16.1(ar)-37(iate analysis, independent p)46(redictors of an increase in the lik)17(eli)]TJ 0 Tw (-)Tj -0.019 Tw T* [(hood of com)16(plications w)12(ere stapler anastomosis \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9.48; 95% CI: 1.88\23157.66; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.008\) and the pN2 \(odd ratio )Tj -0.023 Tw T* (\(OR\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3.63; 95% conf)-42.9(idence inter)-42(v)16(al \(CI\): 1.11\23112.34; p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.03\). The v)13(olume of resection had no signif)-43(icant ef)-40(fect )]TJ -0.019 Tw T* [(on the r)-37(isk of com)16(plications \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.8; 95% CI: 0.97\2318.33; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.11\). With EC, more lym)16(ph nodes w)12(ere remov)13(ed than )]TJ 0.055 Tw T* (with SR)Tj /Span<>> BDC ( )Tj EMC (\227 20)Tj /Span<>> BDC ( )Tj EMC [(\(15.7; 32.2\) v)13(ersus 29)]TJ /Span<>> BDC ( )Tj EMC (\(21; 48\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.005\), while the rate of their metastatic lesion w)13(as 0 \(0; 4\) )]TJ 0.019 Tw T* [(for bo)13.1(th g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.44\), and the 5\231year ov)13(erall sur)-41.9(viv)16(al with a median follow-up of 52 \(34.7; 68.5\) months w)13(as )]TJ -0.006 Tw 0 -1.111 TD [(86% for SR v)13(ersus 78.3% for EC \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.0\) did no)13(t dif)-39.9(fer signif)-43(icantly betw)12(een the g)14(roups. The study of the freq)14(uency )]TJ 0.051 Tw 0 -1.111 TD [(of bow)12.1(el mov)13(ements in the late per)-37(iod w)13(as 2)]TJ /Span<>> BDC ( )Tj EMC [(\(1;2\) times/d)26(ay in bo)13(th g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.97\), as w)11.9(ell as the shape and )]TJ 0.02 Tw T* [(consistency of faeces \(type 3 p)46(rev)16(ailed according to the Br)-37(istol scale)]TJ /Span<>> BDC ( )Tj EMC (\227 31/46)Tj /Span<>> BDC ( )Tj EMC (\(67.4%\) for SR and 20/28)Tj /Span<>> BDC ( )Tj EMC (\(71.4%\) )Tj 0.023 Tw T* (for EC \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\)\) rev)13(ealed no signif)-42.9(icant dif)-39.9(ferences betw)12.1(een the g)14(roups.)]TJ T* [(C)21(ON)22(CLUSION: )0.5(postoperativ)13(e com)16.1(plications in the segmental )0.5(colon resection g)14(roup is low)12(er than in the dilated colon )]TJ 0.08 Tw T* [(g)14(roup. The v)13(olume of surg)12(er)-42.9(y w)13(as no)13(t an independent p)46(redictor of com)16(plications. The lik)17(elihood of their dev)13(elop)]TJ 0 Tw (-)Tj 0.052 Tw T* [(ment w)13(as increased by the use of stapler for anastomosis and the pN2 cr)-36.9(iter)-37(ion. The late results in the g)14(roups did )]TJ 0.023 Tw T* [(no)13(t dif)-40(fer)51.1(.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 505.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colon cancer)61(, segmental resection, e)-15(xtended hemicolectom)11.1(y)41.9(, resection e)-14.9(xtent for transv)13.1(erse colon cancer)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.031 Tc -0.043 Tw -9.871 -2.617 Td [(F)3(O)-4.7(R)8.5( )0.5(C)-17.7(I)-15.7(T)45.2(A)37.4(T)-24.7(I)-1.5(ON:)]TJ /T1_2 1 Tf 0.028 Tc -0.045 Tw 6.325 0 Td [( )0.5(S)0.5(h)2.5(av)-17.2(l)-27(a)-4.2(e)-4.9(v)]TJ /Span<>> BDC 4.001 0 Td ( )Tj EMC 0.216 0 Td [(I)0.5(.)10.4(R)-10.6(.)-12.7(,)10.5( )0.5(S)-1.3(u)3.3(r)-5(o)0.5(v)-7.8(e)-10.2(g)-18.1(i)7.6(n)]TJ /Span<>> BDC 6.313 0 Td ( )Tj EMC 0.216 0 Td [(E)5.2(.)-16(S)1.2(.)-12.7(,)10.5( )0.5(S)-18.5(e)-1.3(r)-5.9(g)-3.6(e)-9.3(y)10.6( )0.5(A)-12.2(.)10.5( )0.5(Fr)-4.9(o)-4.8(l)-10.1(o)0.5(v)21.5(,)10.5( )0.5(M)1(i)7.6(n)-1(g)2.7(a)-16.7(zo)0.6(v)]TJ /Span<>> BDC 13.32 0 Td ( )Tj EMC 0.216 0 Td [(A)-12.2(.)11.3(F)79(.)-12.7(,)10.5( )0.5(B)0.5(l)-12.5(udo)0.5(v)]TJ /Span<>> BDC 4.972 0 Td ( )Tj EMC 0.216 0 Td [(M)3.7(.)23.3(O)22.2(.)-12.7(,)10.5( )0.5(E)3.4(l)-11.6(f)-52.2(i)7.6(m)-1.5(o)0.5(v)-17.6(a)]TJ /Span<>> BDC 6.057 0 Td ( )Tj EMC 0.216 0 Td [(Y)62.1(.)-13(A)-12.2(.)-12.7(,)10.6( K)-9.6(ho)1.6(m)-4.6(y)-13.3(ak)7.1(o)0.5(v)]TJ /Span<>> BDC 6.95 0 Td ( )Tj EMC 0.216 0 Td [(E)5.2(.)-13(A)-12.2(.)-12.7(,)10.5( )0.5(S)-1.2(u)-11.1(s)2(h)2.2(k)7.2(o)0.5(v)]TJ /Span<>> BDC 5.658 0 Td ( )Tj EMC 0.216 0 Td [(O)22.2(.)1(I)0.6(.)28( )]TJ 0.003 Tc -0.035 Tw -55.111 -1.2 Td [(O)-16.7(u)-16(t)-22.2(c)-6.2(o)-8.9(m)-16.3(e)-22.6(s o)-11.9(f)]TJ /Span<>> BDC ( )Tj EMC [(s)-22.6(e)-20.7(g)-8.5(m)-16.4(e)-11.2(n)-17(t)-36.5(a)-11.2(l a)-7.4(n)-14.2(d e)-32.8(x)-44.5(t)-24.4(e)-11.3(n)-14.2(d)-15(e)-20.7(d c)-6.3(o)-15.3(l)-23.4(e)-18.8(c)-41.3(t)-21.6(o)-8.9(m)-15.1(y f)-24.9(o)-11.6(r m)-14.2(i)-8.5(d)-17.4(-)-8(t)-30.5(r)-30.6(a)-7.3(n)-10.9(s)-27.7(v)-18.5(e)-11.8(r)-30(s)-22.6(e c)-6.2(o)-15.4(l)-20.6(o)-8.9(n c)-21.2(a)-7.4(n)-9.7(c)-9.4(e)-11.8(r)30.9(. A)]TJ /Span<>> BDC ( )Tj EMC [(r)-18.8(e)-22.1(t)-30.5(r)-15.5(o)-15.5(s)-9(p)-24.5(e)-18.8(c)-41.2(t)-45.9(i)-14.3(v)-18.4(e s)-29.1(t)-22(u)-10.1(d)-20.2(y)18.3(. )]TJ /T1_0 1 Tf 0.009 Tc -0.009 Tw [(K)10.2(o)-3.8(lo)-3.8(p)-1.4(r)-0.6(ok)-22.9(t)-1.6(o)-3.8(lo)-7(g)-16.9(i)2.9(a)2.1(.)]TJ /T1_2 1 Tf 0.004 Tc -0.036 Tw 49.665 0 Td [( 2)-7.6(0)-2.6(2)5.5(6)21.2(;)11.1(25)2.2(\()38.9(1)45.6(\))15.8(:)22.2(1)1.2(25)-21.4(\226)]TJ 0.023 Tc 0.024 Tw -49.665 -1.2 Td [(1)-7.9(3)7.9(3)6.8(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.6(-)55.2(1)26.9(-)55.1(12)-1.4(5)-23.6(-)55.2(1)-7.9(3)7.9(3)]TJ /T1_1 1 Tf 0.01 Tc 0.087 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.6(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.092 Tw 10.714 0 Td [( )0.5(\237\020\021\f\020\027\021 )0.6(\002.\206., )0.5(\214\216\221\210 )0.6(\253\001\215\002\037 )0.5(\n\031\f\031\033\032\031\n\023\031\f\031\b\022\022 )0.7(\022\026\027\025\022 )0.6(\003.\001.)]TJ /Span<>> BDC ( )Tj EMC 24.721 0 Td [(\206\013\255\022\200\273 )0.6(\215\022\025\016\030\032\020\021\020 )0.6(\206\031\024\024\022\022, )0.6(\r\f.)]TJ /Span<>> BDC ( )Tj EMC 13.179 0 Td [(\205\020\f\t\026\020 )0.6(\003\030\022\f\t, )0.6(\030.)]TJ /Span<>> BDC ( )Tj EMC 7.37 0 Td (2, )Tj 0.023 Tw -55.989 -1.2 Td (\215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: shavlaev\ _ir@gnck.ru)Tj /T1_1 1 Tf 0.01 Tc -0.012 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.5(F)13(OR)5( )0.5(C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc -0.007 Tw 13.99 0 Td [( )0.5(Islam )0.5(R. )0.5(Shavlaev)63(, )0.5(Ryzhikh )0.5(N)18(ational )0.6(Medical )0.5(R)21(esearch )0.5(Center )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 24.888 0 Td [(Colop)46(roctology)42.1(, )0.5(Salyama )0.5(Adilya )0.6(st., 2, )0.5(Moscow)52.1(, )]TJ 0.023 Tw -38.883 -1.2 Td [(123423, R)22(ussia; e-mail: shavlaev_ir@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 22.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 22.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 335.1339 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.166 Tw 10 0 0 10 70.8661 310.7779 Tm (\217\026\022 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \(\217\215\210\025\) \016\r\035\016\ \036\021\f\016 )Tj 0.247 Tw 0 -1.218 TD (\007\024\f\021\026\021\024\004\027\024 \030\036\007\022\024\005 \023\026\ \021\024\035\024\020\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\036\021 \024\022\024\035\024 )Tj -0.016 Tw T* (10% \r\f\036\b \035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\ \r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005\ )Tj 0.009 Tw T* (\022\017\001\022\017. \212\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\020\024 \r\030\036\n\036\027\017 \r\t\002\ \024\030 \024\002\255\036\n\026 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.27 Tw T* (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \035\024\022\026\035\017\026\006\017\017 )Tj 0.151 Tw T* (\024\023\031\b\024\035\017 \024\f\021\026\036\021\f\016 \023\030\036\007\ \n\036\021\024\n \007\017\f\022\031\f\f\017\005. \222\031\013\036\f\021\r\ \031\036\021 )Tj -0.01 Tw T* (\030\016\007 \027\036\030\036\001\036\027\027\t\b \r\024\023\030\024\f\024\ \r, \026\021\030\031\007\027\016\033\013\017\b \f\021\026\027\007\026\030\ \021\017)Tj 0 Tw (-)Tj 0.04 Tw T* (\026\006\017\033 \035\036\004\036\027\017\016, \024\007\027\017\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \016\r\035\016\036\021\f\016 \027\036\004\036\021\ \022\024\036 )Tj -0.034 Tw T* [(\024\023\030\036\007\036\035\036\027\017\036 \f\026\n\024\020\024 \023\024\ \027\016\021\017\016 )0.5(\253\023\024\023\036\030\036\004\027\026\016 \024\002\024\007\024\004\027\ \026\016 )]TJ -0.043 Tw T* (\022\017\001\022\026\273. \222\024\020\035\026\f\027\024 \030\036\022\024\ \n\036\027\007\026\006\017\016\n \212\036\035\034\235\017\005\f\022\024\020\ \024 \022\024\027)Tj 0 Tw (-)Tj 0.13 Tw T* (\f\036\027\f\031\f\026, \253\022 \024\023\031\b\024\035\016\n \023\024\023\ \036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\ \001\022\017 )Tj 0.214 Tw T* (\f\035\036\007\031\036\021 \024\021\027\024\f\017\021\034 \035\033\002\t\ \036 \027\024\r\024\024\002\030\026\024\r\026\027\017\016, \035\024\022\ \026\035\017)Tj 0 Tw (-)Tj 0.044 Tw T* (\024\r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\ \005 \022\017\001\022\036, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033)Tj 0 Tw (-)Tj 0.15 Tw T* (\004\036\027\017\036\n \031\004\026\f\021\022\024\r, \027\026\b\024\007\016\ \013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b 10 \f\n \024\021 )Tj 0.226 Tw T* (\023\036\004\036\027\024\004\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\035\036\036\027\024\004\027\024\020\024 \017\020\017\002\024\r\273\ [1]. \025\030\024\n\036 )Tj -0.034 Tw T* (\021\024\020\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \024\002\255\036\n\026 \030\036\036\022\006\017\017\ , \f\035\036\007\031\036\021 \031\004\017\021\t\r\026\021\034 )Tj 0.022 Tw T* (\021\024\021 \235\026\022\021, \004\021\024 \007\026\027\027\t\005 \f\036\ \020\n\036\027\021 \022\017\001\036\004\027\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\220\n\002\030\017\024\020\036)Tj 0 Tw (-)Tj 0.056 Tw T* (\027\036\036 \030\026\r\017\r\026\036\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \022\017\001\022\017 \017, \021\036\024\030\036\ \021\017\004\036\f\022\017, )Tj 0.122 Tw T* (\035\017\n\235\024\024\021\021\024\022 \024\021 \027\036\036 \r\024\n\024\ \032\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t, \035\024\022\026\035\017)Tj 0 Tw (-)Tj 0.274 Tw T* [(\031\033\013\017\036\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.605 0 Td [(\002\030\t\032\036\005\022\036 )0.5(\023\030\026\r\t\b )0.5(\024\021\007\036\035\024\r )0.5(\024\002\024\007\024\004\027\024\005 )]TJ 0.256 Tw 17.639 25.574 Td [(\022\017\001\022\017, \022\024\021\024\030\t\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 \235\024\030\n\026\035\034\027\024 )0.5(\027\036 )]TJ 0.565 Tw T* (\030\026\f\f\n\026\021\030\017\r\026\033\021\f\016 \022\026\022 \030\036\ \020\017\024\027\026\035\034\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 )Tj 0.133 Tw T* (\035\024\022\026\035\017\026\006\017\017 [2]. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \f\r\016\017, \f\021\024\017\021 \031\023\024\n\016\027\ \031\021\034 \017\f)Tj 0 Tw (-)Tj 0.062 Tw T* [(\f\035\036\007\024\r\026\027\017\036 P)40(ar)-24(k H.M. \(2021\), \020\007\036 \004\026\f\021\024\021\026 \023\024\030\026\ \032\036\027\017\016 )]TJ 0.285 Tw T* (\035\017\n\235\024\031\035\024\r, \030\026\f\023\024\035\024\032\036\027\ \027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \023\030\026\r\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.149 Tw T* (\007\024\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\r\007\024\001\027\024-\024\002\024\007\024\004\027\024\005\ \026\030\021\036\030\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0.111 Tw T* (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017\ \007\024\f\021\017)Tj 0 Tw (-)Tj 0.143 Tw T* (\020\026\035\026 32% [3]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\036\005\f\021\r\031\033\013\017\n\017 \030\024\f)Tj 0 Tw (-)Tj 0.286 Tw T* [(\f\017\005\f\022\017\n\017 )0.5(\022\035\017\027\017\004\036\f\022\017\n\017 )0.5(\030\036\022\024\n\036\027\007\026\006\017\016\n\017 )0.6(\007\024\023\031\f\021\017)]TJ 0 Tw (-)Tj 0.27 Tw T* (\n\t\n\017 \024\002\255\036\n\026\n\017 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \035\036\004\036\027\017\016 \016\r\035\016\033\021\f\ \016 )Tj 0.411 Tw T* (\030\036\036\022\006\017\016 \023\024\023\036\030\036\004\027\024\005 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017, \022\024\021\024\030\ \031\033 )Tj 0.388 Tw T* (\n\024\032\027\024 \f\004\017\021\026\021\034 \253\f\036\020\n\036\027\021\ \026\030\027\024\005\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\030\026\f\001\017\030\036\027\027\t\036\273 )Tj 0.401 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026: \030\026\f\001\017\030\036\ \027\027\026\016 \023\030\026\r\024\f\021\024\030\024\027\027\016\016 \017\ \035\017 )Tj 0.273 Tw T* (\035\036\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\035\ \220\022\021\024\n\017\016. \215\030\036\007\023\024\004\021\017\021\036\ \035\034\027\t\n )Tj 0.063 Tw T* (\024\002\255\036\n\024\n \027\026\t\r\026\036\021\f\016 \f\031\002\021\024\ \021\026\035\034\027\026\016 \030\036\036\022\006\017\016 \024\002\024\007\ \024\004)Tj 0 Tw (-)Tj 0.078 Tw T* (\027\024\005 \022\017\001\022\017. \210\007\027\026\022\024 \f\021\024\017\ \021 \024\021\n\036\021\017\021\034, \004\021\024 \031\030\024\r\036\027\ \034 \031\002\036)Tj 0 Tw (-)Tj 0.12 Tw T* (\007\017\021\036\035\034\027\024\f\021\017 \030\036\022\024\n\036\027\007\ \026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \023\031\027\022\021\031)Tj /Span<>> BDC ( )Tj EMC (\227 \222, )Tj 0.1 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\036\027\034 \007\024\f\021\024\r\036\030\027\024\f\021\017\ \007\024\022\026\026\021\036\035\034\f\021\r)Tj /Span<>> BDC ( )Tj EMC (\227 5, \004\021\024 \027\036 )Tj 0.191 Tw T* (\023\024\r\024\035\016\036\021 \f\004\017\021\026\021\034 \220\021\031 \ \030\036\022\024\n\036\027\007\026\006\017\033 \031\002\036\007\017\021\036\ \035\034\027\024\005 )Tj 0.079 Tw T* ([4]. \222)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t, \030\036\036\022\006\017\ \016 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\004)Tj 0 Tw (-)Tj 0.152 Tw T* (\027\024\005 \022\017\001\022\017 \f\004\017\021\026\036\021\f\016 \n\036\ \027\036\036 \021\030\026\r\n\026\021\017\004\027\024\005 \023\030\024\006\ \036\007\031)Tj 0 Tw (-)Tj 0.047 Tw T* (\030\024\005, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\n\017 \024\023\036\030\026\006\017\016\ \n\017 [5], )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 0 Tw 9 0 0 9 73.5728 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (126)Tj ET endstream endobj 34 0 obj <> endobj 35 0 obj <> endobj 36 0 obj <> endobj 37 0 obj <> endobj 38 0 obj <> endobj 772 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 773 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 774 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 775 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 776 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 784 0 obj [787 0 R] endobj 785 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 235.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 235.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 198.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 198.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-125-133)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 65.8878 695.3259 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022)-23.3(\005\017\016\204\n\005\004\t\t\025\221 \005\004\212\004\r\n\n )]TJ -0.859 -1.105 Td [(\224\005\n\022)-23.3(\005\017\r\004 \016\005\004\202\t\004\221 \026\005\004\026\n \224\025\224\ \004\005\004\225\t\025\221 \025\255\025\202\025\225\t\025\221 \r\n\204\r\ \n. )]TJ 5.022 -1.105 Td [(\033\004\026\005\025\016\224\004\r)-9.9(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\222\017\b\020\017\004\b\022)-23.2(\030.\033)124(., \001\002\005\025\b\004\013\n\t\022)-23.2(\240.\001., \210\005\025\020\025\b\022)-23.3(\001.\f)-30.9(., \235\n\t\013)10(\017\212\025\b\022)-23.2(\f)-31(.\210., \006\020\002\202\025\b\022)-23.2(\235.\036., )]TJ 0 -1.143 TD [(\240\020\216\n\024\025\b\017\022)-23.2(\207.\f)-31(., \205\025\024\213\r)10(\025\b\022)-23.2(\240.\f)-31(., \001\002\204\r)10(\025\b\022)-23.3(\036.\030.)]TJ 10 0 0 10 42.5197 595.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.2(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ 0 -1.2 TD [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0.09 Tw 9 0 0 9 90.7087 564.6488 Tm (\035\027\007\027\025\022\027 \032\020\n\020 \024\032\027\030\025\027\235\ \023\032\027\023\022 \033\031\033\027\032\027\007\025\031\235 \031\240\031\ \030\031\007\025\031\235 \n\022\213\n\022 \t\021\f\t\027\023\024\t \020\n\ \023\r\020\f\017\025\031\235 \033\032\031\240\f\027\026\031\235 \n\031\f\ \031\033\032\031\n\023\031)Tj 0 Tw (-)Tj 0 -1.111 TD (\f\031\b\022\022.)Tj 0.02 Tw T* (\037\036\035\034: \024\032\020\021\025\027\025\022\027 \025\027\033\031\024\ \032\027\030\024\023\021\027\025\025\013\200 \022)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\020\f\027\025\025\013\200 \032\027\016\r\f\017\023\020\023\031\ \021 \033\031\024\f\027 \024\027\b\026\027\025\023\020\032\025\013\200 \022\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\024\213\022\032\027\025\025\013\200 \032\027\016\027\n)Tj 0 Tw (-)Tj 0.023 Tw T* (\006\022\235 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\032\020\n\027 \024\032\027\030\025\027\235 \023\032\027\023\022 \033\031\ \033\027\032\027\007\025\031\235 \031\240\031\030\031\007\025\031\235 \n\ \022\213\n\022.)Tj 0.231 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC [(\215\036\217\220\201: \033\032\031\021\027\030\027\025\031 \032\027\023\ \032\031\024\033\027\n\023\022\021\025\031\027 )0.5(\022\024\024\f\027\030\031\021\020\025\022\027 \032\027\016\r\f\017\023\020\ \023\031\021 \f\027\007\027\025\022\t 86 \033\020\006\022\027\025\023\031\ \021, )]TJ 0.096 Tw 0 -1.111 TD (\031\033\027\032\022\032\031\021\020\025\025\013\200 \021)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\022\031\030 \024)Tj /Span<>> BDC ( )Tj EMC (\t\025\021\020\032\t 2017 \033\031)Tj /Span<>> BDC ( )Tj EMC (\t\025\021\020\032\017 2023 \b\b. \004\020\006\022\027\025\023\013 \032\020\ \016\030\027\f\027\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\013 \024\027\b\026\027\025\023\020\032\025\031\235 )Tj 0.149 Tw 0 -1.111 TD (\032\027\016\027\n\006\022\022 \(\205\206\) \033\031\033\027\032\027\007\ \025\031\235 \031\240\031\030\031\007\025\031\235 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\) \022)Tj /Span<>> BDC ( )Tj EMC (\032\020\024\213\022\032\027\025\025\031\235 \032\027\016\027\n\006\022\022\ \(\206\206\) \031\240\031\030\031\007\025\031\235 \n\022\213\n\022 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\). )Tj 0.005 Tc 0.35 Tw T* [(\217\006\027\025\022\021\020\f\022\024\017 )0.5(\022\025\023\032\020\031\033\027\032\020\006\022\031\025\025\013\027 )0.5(\033\020\032\020\026\027\023\032\013, \007\020\024\023\031\023\020 \022)]TJ /Span<>> BDC ( )Tj EMC 26.285 0 Td [(\200\020\032\020\n\023\027\032 \033\031\024\f\027\031\033\027\032\020\006\ \022\031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235.)5.1( )]TJ 0.349 Tw -26.285 -1.111 Td [(\004)0.5(\032)0.5(\031)0.5(\021)0.5(\031)0.5(\030\022)0.5(\f)0.5(\031)0.5(\024)0.5(\017)0.5( \022)0.5(\016)0.5(\r\007)0.5(\027)0.5(\025)0.5(\022)0.5(\027)0.5( \032)0.5(\027)0.5(\016)0.5(\r\f)0.5(\017)0.5(\023)0.5(\020)0.5(\023)0.5(\031)0.5(\021)0.5( \033)0.5(\020\023)0.5(\031)0.5(\026)0.5(\031)0.5(\032)0.5(\203)0.5(\031)0.5(\f)0.5(\031)0.5(\b\022)0.5(\007)0.5(\027)0.5(\024)0.5(\n)0.5(\031)0.5(\b\031)0.5( \022)0.5(\024)0.5(\024)0.5(\f)0.5(\027)0.5(\030)0.5(\031)0.5(\021)0.5(\020)0.5(\025\022)0.5(\t)0.5( \031)0.5(\033)0.5(\027)0.5(\032)0.5(\020)0.5(\006\022)0.5(\031)0.5(\025)0.5(\025)0.5(\013)0.5(\200)0.5( \033)0.5(\032\027)0.5(\033)0.5(\020)0.5(\032)0.5(\020)0.5(\023)0.5(\031)0.5(\021)0.5(.)5( )]TJ 0 Tc 0.077 Tw T* (\002\016\r\007\020\f\022\024\017 \031\023\030\020\f\027\025\025\013\027 \ \032\027\016\r\f\017\023\020\023\013 \f\027\007\027\025\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\203\r\025\n\006\022\031\025\020\f\017\025\013\027 \022\024\200\031\030\013\ \031\033\027\032\020\006\022\235 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\027\030\022\n\023\031\032\013 \032\020\016\021\022\023\022\t )Tj 0 Tw T* (\031\024\f\031\255\025\027\025\022\235.)Tj 0.026 Tw 0 -1.111 TD [(\206\036\207\210\035\034\003\201: \007\020\024\023\031\023\020 \033\031\ \024\f\027\031\033\027\032\020\006\022\031\025\025\013\200 )0.5(\031\024\f\031\255\025\027\025\022\235 \021)]TJ /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \205\206 \240\013\f\020 \025\022\255\027, \007\027\026\ \033\031\024\f\027 \032\020\024\213\022\032\027\025\025\013\200 \031\033\ \027)Tj 0 Tw (-)Tj 0.046 Tw 0 -1.111 TD (\032\020\006\022\235)Tj /Span<>> BDC ( )Tj EMC (\227 11/55 \(20%\) \033\032\031\023\022\021 13/31 \(41,9%\) \024\f\r\007\ \020\027\021, \024\031\031\023\021\027\023\024\023\021\027\025\025\031\(\ p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\r\f\017\023\022\021\020\032\022\020\025\023\025\031\026 )Tj 0.096 Tw T* [(\020\025\020\f\022\016\027 )0.5(\025\027\016\020\021\022\024\022\026\013\026\022 )0.5(\033\032\027\030\022\n\023\031\032\020\026\022 )0.5(\r\021\027\f\022\007\027\025\022\t )0.6(\021\027\032\031\t\023\025\031\024\023\022 )0.6(\032\020\016\021\022\023\022\t )0.5(\031\024\f\031\255\025\027\025\022\235 )0.5(\024\023\020\f\022: )0.5(\203\031\032\026\022\032\031\021\020)]TJ 0 Tw (-)Tj 0.067 Tw T* [(\025\022\027 \020\025\020\024\023\031\026\031\016\020 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC [(\033\031\026\031\212\017\005 )0.5(\024\213\022\021\020\005\212\022\200 \020\033\033\020\032\020\023\031\021\ )0.5(\(\031\023\025\031\213\027\025\022\027 )0.5(\213\020\025\024\031\021 \(\217\237\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9,48; 95% \030\031\021\027\032\022\023\027\f\017\025\013\235 )Tj 0.101 Tw T* (\022\025\023\027\032\021\020\f \(\220\002\): 1,88\23157,66; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \022)Tj /Span<>> BDC ( )Tj EMC (\n\032\022\023\027\032\022\235 pN2 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,63; 95% \220\002: 1,11\23112,34; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \217\240\236\027\026 )Tj 0.14 Tw T* [(\032\027\016\027\n\006\022\022 )0.6(\025\027 )0.5(\031\n\020\016\013\021\020\f )0.6(\024\023\020\023\022\024\023\022\007\027\024\n\022 )0.6(\016\025\020\007\022\026\031\b\031 )0.6(\021\f\022\t\025\022\t )0.6(\025\020)]TJ /Span<>> BDC ( )Tj EMC 26.491 0 Td [(\032\022\024\n )0.6(\032\020\016\021\022\023\022\t )0.6(\031\024\f\031\255\025\027\025\022\235 )0.6(\(\217\237)]TJ /Span<>> BDC ( )Tj EMC 14.045 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.872 0 Td [(2,8; )0.5(95% )]TJ 0.013 Tw -41.408 -1.111 Td (\220\002: 0,97\2318,33; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,11\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\206\206 \r\030\020\f\t\f\031\024\017 \240\031\f\017\213\027 \f\022\026\203\ \031\r\016\f\031\021, \007\027\026 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\205\206)Tj /Span<>> BDC ( )Tj EMC (\227 20)Tj /Span<>> BDC ( )Tj EMC (\(15,7; 32,2\) \033\032\031\023\022\021 29)Tj /Span<>> BDC ( )Tj EMC (\(21; )Tj 0.027 Tw T* (48\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005\), \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \007\020\024\023\031\023\020 \022\200 \026\027\023\020\024\ \023\020\023\022\007\027\024\n\031\b\031 \033\031\032\020\255\027\025\022\ \t)Tj /Span<>> BDC ( )Tj EMC (\227 0 \(0; 4\) \030\f\t \031\240\027\022\200 \b\032\r\033\033 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\), )Tj 0.008 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (5-\f\027\023\025\t\t \031\240\212\020\t \021\013\255\022\021\020\027\026\ \031\024\023\017 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\027\030\022\020\025\027 \033\032\031\024\f\027\255\027\025\025\031\024\ \023\022 \021)Tj /Span<>> BDC ( )Tj EMC (52 \(34,7; 68,5\) \026\027\024\t\006\020 \024\031\024\023\020\021\022\f\020\ 86% \030\f\t )Tj 0 Tw 0 -1.111 TD (\205\206 \033\032\031\023\022\021 78,3% \030\f\t \206\206 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\) \026\027\255\030\r \b\032\r\033\033\020\026\022 \024\023\020\023\022\ \024\023\022\007\027\024\n\022 \016\025\020\007\022\026\031 \025\027 \032\ \020\016\f\022\007\020\f\022\024\017. \002\016\r\007\027\025\022\027 \007\ \020\024\023\031)Tj (-)Tj 0.096 Tw 0 -1.111 TD (\023\013 \030\027\203\027\n\020\006\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\020\f\027\025\025\031\026 \033\027\032\022\031\030\027)Tj /Span<>> BDC ( )Tj EMC (\227 \033\031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\) \032\020\016\020/\024\r\023\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\027\022\200 \b\032\r\033\033 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,97\), \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \203\031\032\026\013 )Tj 0.037 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 0.769 0 Td [(\n\031\025\024\022\024\023\027\025\006\022\t )0.5(\n\020\f\020 )0.5(\(\033\032\027\031\240\f\020\030\020\f \023\022\033 )0.5(3 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 17.313 0 Td [(\024\031\031\023\021\027\023\024\023\021\022\022 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 7.221 0 Td [(\221\032\022\024\023\031\f\017\024\n\031\235 )0.5(\213\n\020\f\031\235)]TJ /Span<>> BDC ( )Tj EMC 9.497 0 Td [(\227 )0.5(31/46)]TJ /Span<>> BDC ( )Tj EMC (\(67,4%\) \030\f\t \205\206 )Tj 0.023 Tw -34.799 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (20/28)Tj /Span<>> BDC ( )Tj EMC (\(71,4%\) \030\f\t \206\206 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\)\) \025\027 \021\013\t\021\022\f\031 \024\023\020\023\022\024\023\022\ \007\027\024\n\022 \016\025\020\007\022\026\013\200 \032\020\016\f\022\007\ \022\235 \026\027\255\030\r \b\032\r\033\033\020\026\022.)Tj 0.008 Tc 0.35 Tw T* (\207\003\202\035\224\232\036\001\002\036: \007\020\024\023\031\023\020 \032\ \020\016\021\022\023\022\t \033\031\024\f\027\031\033\027\032\020\006\022\ \031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235 \021)Tj /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\027 \024\027\b\026\027\025\023\020\032\025\031\235 \032\ \027\016\027\n\006\022\022)8( )]TJ 0 Tc 0.132 Tw T* [(\033\031\033\027\032\027\007\025\031\235 )0.5(\031\240\031\030\031\007\025\031\235 )0.5(\n\022\213\n\022 \025\022\255\027, )0.5(\007\027\026 \021)]TJ /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\027 )0.5(\032\020\024\213\022\032\027\025\025\013\200. )0.5(\217\240\236\027\026 )0.5(\031\033\027\032\020\006\022\022 \025\027 )0.5(\t\021\f\t\f\024\t \025\027\016\020\021\022\024\022\026\013\026 )]TJ 0.007 Tw T* (\033\032\027\030\022\n\023\031\032\031\026 \032\020\016\021\022\023\022\t\ \031\024\f\031\255\025\027\025\022\235. \211\027\032\031\t\023\025\031\024\ \023\017 \022\200 \032\020\016\021\022\023\022\t \033\031\021\013\213\020\ \f\031 \022\024\033\031\f\017\016\031\021\020\025\022\027 \024\213\022\021\ \020\005\212\022\200 \020\033\033\020)Tj 0 Tw (-)Tj 0.058 Tw T* (\032\020\023\031\021 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\203\031\032\026\022\032\031\021\020\025\022\022 \026\027\255\n\022\213\027\ \007\025\031\b\031 \020\025\020\024\023\031\026\031\016\020 \022)Tj /Span<>> BDC ( )Tj EMC (\n\032\022\023\027\032\022\235 pN2. \217\023\030\020\f\027\025\025\013\027\ \032\027\016\r\f\017\023\020\023\013 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 )Tj 0.023 Tw T* (\025\027 \032\020\016\f\022\007\020\f\022\024\017.)Tj /T1_2 1 Tf 0.01 Tc 0.002 Tw 8 0 0 8 42.5596 269.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.007 Tw 8.477 0 Td ( \032\020\n \031\240\031\030\031\007\025\031\235 \n\022\213\n\022, \024\027\ \b\026\027\025\023\020\032\025\020\t \032\027\016\027\n\006\022\t, \032\020\ \024\213\022\032\027\025\025\020\t \b\027\026\022\n\031\f\204\n\023\031\026\ \022\t, \031\240\236\027\026 \032\027\016\027\n\006\022\022 \033\032\022\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\n\027 \033\031\033\027\032\027\007\025\031\235 )Tj 0.023 Tw -8.482 -1.2 Td (\031\240\031\030\031\007\025\031\235 \n\022\213\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.019 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.9( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.009 Tc -0.035 Tw 8.907 0 Td ( \231\026\r\035\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\217., \222\031\030\024\r\036\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\213.\222., \205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \204\017\027\020\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\205., \207\035\031\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\210., \213\035\235\017\n\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \216\024\n\016\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \222\031\001\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\210.\230.)9( )]TJ 0.022 Tc -8.912 -1.2 Td (\217\036\031\035\034\021\026\021\t \f\036\020\n\036\027\021\026\030\027\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 \f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\ \023\036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017. \217\036\021\030\024\f\023\036\022\021\017\r\027\024\036\ \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (\007\024\r\026\027\017\036. )Tj /T1_1 1 Tf 4.19 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (125\226133. https://doi.org/10.33878/2073-7556-2026-25-1-125-133)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 82.3034 172.0331 Tm [(Outcomes of\022)-23.3(segmental and e)21(xtended colectom)21(y for )]TJ 0.436 -1.167 Td [(mid-tr)21(ans)21.1(v)12(er)20(se colon cancer)52.1(. A\022)-23.3(r)31(etr)20(ospectiv)12.1(e study)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 126.5292 Tm [(Islam\022)-23.2(R.\022)-23.3(Shavlae)11(v)21(, Ev)10(genii\022)-23.2(S.\022)-23.3(Sur)20(ov)12(egin, Ser)31(gey\022)-23.3(A)-31(.\022)-23.3(Fr)20.1(olov)21(, Air)21(at\022)-23.3(F)94(.\022)-23.3(Minga)20.1(z)10(ov)21(, )]TJ 0 -1.143 TD [(Maxim\022)-23.2(O.\022)-23.3(Bludov)21(, Y)40(ulia\022)-23.3(A)-31(.\022)-23.3(Elf)-21(imov)10.1(a, Ev)10(geniy\022)-23.3(A)-31(.\022)-23.2(Kh)11(om)21(y)21(ak)11(ov)21(, Oleg\022)-23.3(I.\022)-23.3(Sushk)11.1(ov)]TJ 10 0 0 10 42.5197 92.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 573.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 564.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 505.4397 56.0378 Tm (125)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 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(\022\026\032)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD (\007\024\020\024 \023\016\021\024\020\024 \023\026\006\017\036\027\021\026\ \n\024\032\036\021 \002\t\021\034 \007\024\f\021\017\020\027\031\021 \023\ \024\035\027\t\005 )Tj 0 Tw T* (\024\021\r\036\021 \024\023\031\b\024\035\017.)Tj 0.014 Tw T* (\222\030\036\007\017 \024\020\030\026\027\017\004\036\027\017\005 \017\f\ \f\035\036\007\024\r\026\027\017\016 \f\021\024\017\021 \r\t\007\036\035\ \017\021\034 \024\021)Tj 0 Tw (-)Tj 0.086 Tw T* (\f\031\021\f\021\r\017\036 \024\f\035\036\023\035\036\027\017\016, \004\021\ \024 \n\024\020\035\024 \023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\031\002\255\036\022)Tj 0 Tw (-)Tj -0.025 Tw T* (\021\017\r\027\031\033 \024\006\036\027\022\031 \021\024\022\f\017\004\027\ \024\f\021\017 \035\031\004\036\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017. )Tj 0.18 Tw 0 -1.218 TD [(\230\f\f\035\036\007\024\r\026\027\017\036 \023\030\024\r\024\007\017\035\ \024\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\031\022\024\023\030\024\235\017\035\034\027\024\n )0.5(\f\023\036)]TJ 0 Tw (-)Tj 0.291 Tw 0 -1.218 TD (\006\017\026\035\017\017\030\024\r\026\027\027\024\n \006\036\027\021\030\ \036, \004\021\024 \n\024\032\036\021 \024\020\030\026\027\017\004\017\r\ \026\021\034 )Tj 0.117 Tw T* (\024\002\024\002\013\026\036\n\024\f\021\034 \030\036\031\035\034\021\026\ \021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \001\017\030\024\022\031\033 \023\024\023\031)Tj 0 Tw (-)Tj 0.224 Tw T* (\035\016\006\017\033. \221\026\022\032\036 \f\035\036\007\031\036\021 \024\ \021\n\036\021\017\021\034 \027\036\002\024\035\034\001\024\005 \023\036\ \030\017\024\007 )Tj -0.043 Tw T* (\027\026\002\035\033\007\036\027\017\016 \023\026\006\017\036\027\021\024\ \r, \004\021\024 \027\036 \007\024\f\021\026\021\024\004\027\024 \007\035\ \016 \024\006\036\027\022\017 )Tj 0 Tw T* (\024\021\007\026\035\036\027\027\t\b \024\027\022\024\035\024\020\017\004\ \036\f\022\017\b \030\036\031\035\034\021\026\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 554.3378 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.019 Tw 10 0 0 10 42.5197 529.9818 Tm [(\025\024\030\024\021\022\017\005 )0.5(\022\031\030\f \035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 \f)]TJ /Span<>> BDC ( )Tj EMC 14.176 0 Td (\022\031\030\f\024\n \022\024\027\f\024\035\017\007\017)Tj 0 Tw (-)Tj -0.033 Tw -14.176 -1.218 Td (\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\017 \f\ \024\023\024\f\021\026\r\017\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \023\024\035\027\t\b )Tj 0.055 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021\r\036\021\024\r \024\023\031\b\024)Tj 0 Tw (-)Tj 0.177 Tw T* (\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005 \b\017\n\017\ \024\035\031\004\036\r\024\005 )Tj 0 Tw T* (\021\036\030\026\023\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\024\n \022\024\027\f\024\035\017\007\017\030\031\033\013\036\ \005 \b\017\n\017\024\021\036\030\026\023\017\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.243 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.8()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.4(\016)13.7(:)]TJ /T1_4 1 Tf -0.003 Tc 0.246 Tw [( \003)-20.4(\f\027\n)6.3(\024)6.8(\027)-3.9(\027)3.6(\021)]TJ /Span<>> BDC 19.73 0 Td ( )Tj EMC [(\215)16.4(.)25.5(\211)21.3(.)4.8(,)-3( )]TJ -0.029 Tc 0.029 Tw -19.73 -1.218 Td [(\214)-19.1(\020)-24.6(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 3.841 0 Td ( )Tj EMC [(\206)64.9(.\002.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.841 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.8(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw [( \214)-19.1(\020)-24.5(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 16.813 0 Td ( )Tj EMC [(\206)64.9(.\002.)]TJ /T1_1 1 Tf 0.018 Tc 1.544 Tw 6.431 30.445 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf -0.029 Tc 1.591 Tw 12.911 0 Td [( \214)-19.1(\020)-24.6(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 5.636 0 Td ( )Tj EMC [(\206)64.9(.\002.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -18.547 -1.218 Td [(\221)-5(\020)-15.2(\f\n)2.7(\020)-8.2(\032)-9.9(\031\021)]TJ /Span<>> BDC 3.81 0 Td ( )Tj EMC [(\003)-12.3(.)-2.7(\003)-12.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -3.81 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw 7.694 0 Td [( \214)-19.1(\020)-24.6(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 4.074 0 Td ( )Tj EMC [(\206)64.9(.\002.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.767 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \003)-27.3(\f)-6.7(\027)-7.1(\n)-0.7(\024\027)-10.9(\027)-3.4(\021)]TJ /Span<>> BDC 11.023 0 Td ( )Tj EMC [(\215)9.4(.)18.5(\211)14.4(.)-2.2(,)-10( \206)13.8(\013)-8.3(\240)-5.3(\020)-5.1(\n\031\021)]TJ /Span<>> BDC 5.844 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\216)112(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -16.867 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.124 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.3(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf -0.005 Tc 0.129 Tw [( M)5.4(i)3(kha)-7(i)2.4(l)]TJ /Span<>> BDC 17.13 0 Td ( )Tj EMC [(V)48.1(.)]TJ /Span<>> BDC 1.079 0 Td ( )Tj EMC [(A)-1.3(le)-5.2(k)-22.5(se)-11.2(e)-9(v)28.6(,)-5( )]TJ -0.01 Tc 0.01 Tw -18.21 -1.218 Td [(Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 2.583 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -3.447 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.01 Tc 0.01 Tw -15.798 -1.218 Td [(Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 2.583 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_1 1 Tf -0.007 Tc 1.421 Tw -3.447 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf 0 Tc 1.414 Tw 10.502 0 Td [( R)10.1(a)-3(s)9.6(h)6.2(i)3(d)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(F)25.4(a)-5.9(y)-2.5(z)13(u)2.8(l)4.3(i)8.4(n)-5.9(, )]TJ 0 Tw -10.502 -1.218 Td [(A)4.8(r)-38.3(t)-30(y)0.9(om)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(al)-6.3(k)15.8(ar)2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0 -1.218 TD [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 10.729 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -11.593 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( M)10.5(i)7.9(k)5.3(h)4.8(a)-1.9(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.9(ek)-17.4(s)4.9(e)-6.2(e)-4(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-8.9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw T* (\205\026\005\031\035\017\027 \217.\230.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-0719-7910)Tj T* (\202\035\036\022\f\036\036\r \204.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* (\217\t\002\026\022\024\r \213.\206.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj T* (\207\026\035\022\026\030\024\r \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-7342-5753)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(R)-10(ashid I. F)20.1(a)15(yzul)-31(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0719-7910)Tj T* [(Mikhail V. Alek)-9.9(seev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* [(Ev)-21(geny G. R)-19.9(ybakov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj T* [(Ar)-22(t)-9.9(yom A. Balk)-16.9(ar)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7342-5753)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 383.8459 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.004 Tw 8 0 0 8 42.5197 371.0112 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(udmir)]TJ /Span<>> BDC ( )Tj EMC [(EB, P)40(al)56(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(M, W)-16(ille)-11.9(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(CG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)17(t)15(al neoad)17(juv)-14.9(ant t)-13(her)-33(apy for )]TJ -0.019 Tw -1.296 -1.25 Td [(r)-24(ec)-16(t)15.1(al cancer: An)]TJ /Span<>> BDC ( )Tj EMC [(emer)-32(ging opt)-32(ion. )]TJ /T1_4 1 Tf 0 Tw (Cancer)Tj /T1_1 1 Tf -0.019 Tw [(. 2017 Ma)15(y 1;123\(9\):1497\226)]TJ 0.023 Tw 0 -1.25 TD [(1506. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cncr.30600)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2017 Mar 10. PMID: 28295220.)Tj 0.304 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(asi)]TJ /Span<>> BDC ( )Tj EMC [(A, A)-13.9(bbasi)]TJ /Span<>> BDC ( )Tj EMC [(S, Hand)42(a)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)17(t)15(al Neoad)17(juv)-14.9(ant T)47(her)-33(apy )]TJ 0.018 Tc 0.66 Tw -1.296 -1.25 Td [(vs S)14.8(t)14.9(and)41.8(ar)-24.2(d T)46.8(her)-33.2(apy in L)34.8(o)-16.2(call)34.8(y A)14.8(d)-17.1(v)-15.2(anced R)12.8(ec)-16.1(t)14.8(al Cancer:)18( )]TJ 0 Tc 0.302 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_4 1 Tf [(J)30(AMA N)18(etw Open)]TJ /T1_1 1 Tf (. 2020 )Tj 0.074 Tw T* [(Dec 1;3\(12\):e2030097. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/jamane)-12(t)-32(w)-13.9(or)-24(kopen.2020.30097)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (PMID: 33326026; PMCID: PMC7745099.)Tj 0.146 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(ok)-17(as)]TJ /Span<>> BDC ( )Tj EMC [(E, All)16(g\344uer)]TJ /Span<>> BDC ( )Tj EMC [(M, P)10(ol)-16(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ger)-15.9(man R)13(ec)-16(t)15(al Cancer S)15(tud)17.1(y )]TJ 0.01 Tc 0.379 Tw -1.296 -1.25 Td [(G)19.8(r)-32.1(oup. R)-10.2(and)-16.2(omized Phase II T)49.8(r)-37.2(ial of)]TJ /Span<>> BDC ( )Tj EMC [(Chemor)-33.1(adio)16.8(t)-13.1(her)-33.1(apy Pl)34.8(us)10( )]TJ 0.001 Tc 0.35 Tw T* [(Induc)-16.4(t)-32.4(ion or Consol)-31.4(id)41.6(a)14.6(t)-32.3(ion Chemo)16.7(t)-13.4(her)-33.4(apy as T)44.6(o)16.7(t)14.6(al Neoad)16.6(juv)-15.4(ant)1( )]TJ 0 Tc 0.036 Tw T* [(T)47(her)-33(apy for L)35(o)-16(call)35(y A)15(d)-17(v)-14.9(anced R)13(ec)-16(t)15(al Cancer: C)20(A)15(O/ARO/AIO-12. )]TJ /T1_4 1 Tf (J Clin )Tj 0 Tw T* (Oncol.)Tj /T1_1 1 Tf 0.194 Tw [( 2019 Dec 1;37\(34\):3212\2263222. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1200/JC)13(O.19.00308)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* [(Epub 2019 Ma)15.1(y 31. PMID: 31150315.)]TJ 0.002 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bahad)-16(oer)]TJ /Span<>> BDC ( )Tj EMC [(RR, Dijk)-10(str)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(EA, v)-15(an Et)-30(ten)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. RAPIDO coll)-16(abor)-33(a)15(t)-32(i)-15.9(ve )]TJ 0.096 Tw -1.296 -1.25 Td [(invest)-31.9(iga)15(t)17(or)-10(s. S)-15.9(hor)-22(t-cour)-10(se r)-33(adio)17(t)-12.9(her)-33(apy foll)30.1(o)-14(wed b)12(y chemo)17(t)-13(her)-32.9(apy )]TJ 0.109 Tw T* [(befor)-24(e t)17(o)17(t)15(al mesor)-24(ec)-16(t)15(al e)-18(x)-13(c)-23.9(ision \(TME\) ver)-10(sus p)25(r)-24(eoper)-33(a)15(t)-31.9(i)-16(ve chemo)]TJ 0 Tw (-)Tj 0.188 Tw T* [(r)-33(adio)17(t)-12.9(her)-33(apy, TME, and )0.5(opt)-32(ional ad)17(juv)-15(ant )0.5(chemo)17(t)-13(her)-32.9(apy in l)30(o)-16(call)35(y )]TJ 0.133 Tw T* [(ad)-17(v)-15(anced r)-23.9(ec)-16(t)15(al cancer \(RAPIDO\): a)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omised, open-l)-16(abel, phase )]TJ 0.17 Tw T* [(3 tr)-37(ial. )]TJ /T1_4 1 Tf (Lancet Oncol.)Tj /T1_1 1 Tf [( 2021 Jan;22\(1\):29\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-)Tj 0.001 Tc -0.001 Tw T* [(2)0.5(04)0.5(5\()0.5(2)0.5(0\))0.5(30)0.5(55)0.5(5)0.5(-6)]TJ 0 0 0 1 k /GS1 gs 0.349 Tw 7.1 0 Td [( E)0.5(pu)0.5(b 2)0.5(02)0.5(0)0.5( De)0.5(c 7)0.5(.)0.5( E)0.5(r)-23.5(r)-32.5(a)15.4(t)0.5(u)0.5(m i)0.5(n)0.5(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw ( )Tj /T1_1 1 Tf 0.001 Tc 0.349 Tw 14.656 0 Td [(L)-31.5(an)0.5(c)0.5(e)-11.6(t)0.5( O)0.5(nc)0.5(ol)0.5(.)1( )]TJ 0 Tc 0.268 Tw -21.756 -1.25 Td [(2021 F)10(eb;22\(2\):e42. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-2045\(20\)30781-6)Tj 0 0 0 1 k /GS1 gs 0.268 Tw ( PMID: )Tj 0 Tw T* (33301740.)Tj -0.006 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cl)-16(av)-15.9(ien)]TJ /Span<>> BDC ( )Tj EMC [(P)25.1(A, Bar)-24(kun)]TJ /Span<>> BDC ( )Tj EMC [(J, de Ol)-31(i)-16(veir)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(ML, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Cl)-16(av)-15.9(ien-Dind)-16(o cl)-16(as)]TJ 0 Tw (-)Tj 0.041 Tw -1.296 -1.25 Td [(sif)-28(ica)15(t)-31.9(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.219 0 Td [(sur)-32(gical )0.6(com)10(pl)-31(ica)15(t)-31.9(ions: )0.5(f)-28(i)-16(ve-year )0.7(e)-18(xper)-37(ience. )]TJ /T1_4 1 Tf 18.563 0 Td [(Ann )0.5(Surg)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.01 Tc 0.375 Tw -23.781 -1.25 Td [(2009 A)10(ug;250\(2\):187\22696. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw [(10.1097/SL)-35(A.0b013e3181b13ca2)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 19638912.)Tj -0.021 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Co)14(x)]TJ /Span<>> BDC ( )Tj EMC [(JD, S)15(te)-12(tz)]TJ /Span<>> BDC ( )Tj EMC 5.274 0 Td [(J, P)40(ajak)]TJ /Span<>> BDC ( )Tj EMC [(TF. )0.5(T)45(o)14(xic)-24(i)-24(t)-10(y )0.5(cr)-37(i)-24(ter)-36.9(ia of)]TJ /Span<>> BDC ( )Tj EMC 12.227 0 Td [(t)-13(he )0.5(R)-10(adia)15(t)-32(ion )0.5(T)47(her)-33(apy )]TJ 0.039 Tw -18.797 -1.25 Td [(Oncol)30(o)-16(g)16(y G)20(r)-32(oup \(R)-12(T)20(OG\) and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Eur)-31.9(opean Or)-32(ganiza)15(t)-32(ion for R)13(esear)-32(ch )]TJ 0.053 Tw T* [(and T)50(r)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(Cancer \(EOR)-11.9(T)35(C\). )]TJ /T1_4 1 Tf [(Int J R)20(adiat Oncol Biol Ph)12(ys.)]TJ /T1_1 1 Tf ( 1995 )Tj 0.229 Tw 29.055 36.25 Td [(Mar 30;31\(5\):1341\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/0360-3016\(95\)00060-C)Tj 0 0 0 1 k /GS1 gs 0.229 Tw ( PMID: )Tj 0 Tw T* (7713792.)Tj 0.295 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(r)-24(ei)-23.9(tes-Mar)-22(t)-32(inez)]TJ /Span<>> BDC ( )Tj EMC [(A, Sant)15(ana)]TJ /Span<>> BDC ( )Tj EMC [(N, Ar)-36.9(ias-Sant)-32(ia)-17(go)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Using )Tj 0.296 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Common T)40(er)-16(minol)30(o)-16(g)16(y Cr)-37(i)-24(ter)-36.9(ia for A)15.1(d)-17.1(ver)-9.9(se Events \(CT)35(C)20(AE)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj -0.002 Tw T* [(V)30(er)-10(sion 5.0\) t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Ev)-15(al)35(ua)15(te t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Sever)-36.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(A)15(d)-17(ver)-9.9(se Events of)]TJ /Span<>> BDC ( )Tj EMC [(Ant)-31.9(icancer )]TJ 0 Tw T* [(T)47(her)-33(apies. )]TJ /T1_4 1 Tf 0.169 Tw 4.546 0 Td [(Actas Der)-14(mosif)-42.9(iliog)14(r \(Eng)13(l Ed\).)]TJ /T1_1 1 Tf ( 2021 Jan;112\(1\):90\22692. )Tj 0.137 Tw -4.546 -1.25 Td [(Engl)-31(ish, Sp)32(anish. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ad.2019.05.009)Tj 0 0 0 1 k /GS1 gs 0.137 Tw ( Epub 2020 Sep 3. )Tj 0.023 Tw T* (PMID: 32891586.)Tj 0.01 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(or)-24(r)-23.9(est)]TJ /Span<>> BDC ( )Tj EMC 3.044 0 Td [(J)15(A, )0.5(F)-19(inl)-16(a)15(y)-12.9(son)]TJ /Span<>> BDC ( )Tj EMC [(ND, )0.5(S)-16(hear)-15.9(man)]TJ /Span<>> BDC ( )Tj EMC 11.269 0 Td [(DJ. )0.5(End)-16(oscopy )0.5(in )0.5(gastr)-32(ointes)]TJ 0 Tw (-)Tj 0.121 Tw -15.609 -1.25 Td [(t)-32(inal bleeding. )]TJ /T1_4 1 Tf 0 Tw (Lancet)Tj /T1_1 1 Tf 0.121 Tw [(. 1974 A)10(ug 17;2\(7877\):394\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj T* (s0140-6736\(74\)91770-x)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 4136718.)Tj 0.027 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, P)30(er)-23.9(ez)]TJ /Span<>> BDC ( )Tj EMC [(RO, Nad)42(al)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15.1(t)-32(i)-16(ve ver)-10(sus nonop)]TJ 0 Tw (-)Tj 0.015 Tw -1.296 -1.25 Td [(er)-33(a)15(t)-31.9(i)-16(ve tr)-24(ea)15(tment for st)15(a)-17(ge 0 dist)15(al r)-24(ec)-15.9(t)15(al cancer foll)30(o)-14(wing chemor)-32.9(a)]TJ 0 Tw (-)Tj 0.058 Tw T* [(dia)15(t)-32(ion t)-13(her)-32.9(apy: l)30(ong-ter)-16(m r)-24(esul)56.1(ts. )]TJ /T1_4 1 Tf (Ann Surg.)Tj /T1_1 1 Tf [( 2004 O)-16(c)-15.9(t;240\(4\):711\226)]TJ 0.009 Tc 0.349 Tw T* [(7; discussion 717-8. d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw [(10.1097/01.sl)-15.6(a.0000141194.27992.32)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 15383798; PMCID: PMC1356472.)Tj 0.318 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jin)Tj /Span<>> BDC ( )Tj EMC [(J, T)40(ang)]TJ /Span<>> BDC ( )Tj EMC (Y, Hu)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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-0.016 Tw 0 -1.218 TD (\030\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\021\007\036\035\034\027\024 \f\021\024\017\021 \r\t\007\ \036\035\017\021\034 \024\f\035\024\032\027\036\027\017\016 III )Tj 0 Tw T* (\f\021\036\023\036\027\017.)Tj 0.319 Tw T* (\200 \020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\n \023\026\006\017\036\027\021\026\n \023\024\021\030\036\ \002\024\r\026\035\024\f\034 \023\024\r)Tj 0 Tw (-)Tj 0.286 Tw T* [(\021\024\030\027\024\036 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\036 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\024. )0.6(\210\f\035\024\032\027\036\027\017\036 )]TJ 0.251 Tw T* (III\202)Tj /Span<>> BDC ( )Tj EMC 2.16 0 Td [(\227 \032\036\035\031\007\024\004\027\024\036 \022\030\024\r\024\021\036\ \004\036\027\017\036 )0.5(\(F)10(or)-24(r)-23.9(est 1B\) [8] )]TJ -0.074 Tw -2.16 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\024\005 \220\030\024\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \021\036\035\026 \032\036\035\031\007\022\026\ \(\026\030\036\020\017\f\021\030\017)Tj 0 Tw (-)Tj 0.067 Tw T* (\030\024\r\026\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \f\031\021\022\017 \023\024\f\035\036 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.148 Tw T* (\f\021\r\026\))Tj /Span<>> BDC ( )Tj EMC 2.504 0 Td [(\227 )0.5(\022\031\023\017\030\024\r\026\027\024 )0.5(\023\031\021\036\n )0.6(\031\f\021\026\027\024\r\022\017 )0.5(\220\027\007\024\f\022\024\023\017\004\036)]TJ 0 Tw (-)Tj 0.045 Tw -2.504 -1.218 Td (\f\022\024\005 \022\035\017\023\f\t. \210\f\035\024\032\027\036\027\017\036\ IIIB)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )Tj 0.131 Tw T* (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\ \f\021\024\n\024\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (6-\036 \f\031\021\022\017 \023\024\f\035\036 \035\026)Tj 0 Tw (-)Tj 0.75 Tw T* (\023\026\030\024\f\022\024\023\017\004\036\f\022\017-\026\f\f\017\f\021\017\ \030\031\036\n\024\005 \027\017\022\024\005 \023\036\030\036\007\027\036\ \005 )Tj 0.129 Tw 0 -1.218 TD (\030\036\036\022\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017\ , \017\035\036\024\f\021\024\n\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\221\024\030\027\002\024\035\035\031. )Tj 0.012 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\021\024\030\027\024\n \b\017\030\031\030\020\017\004\036\f\022\ \024\n )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\036 \023\024\021\030\036)]TJ 0 Tw (-)Tj 0 -1.218 TD (\002\024\r\026\035\024\f\034 \030\026\024\002\013\036\027\017\036 \022\024\ \035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\ \n\024\026.)Tj -0.011 Tw T* (\200 \020\030\031\023\023\036 \207 \024\f\035\024\032\027\036\027\017\036\ IIIB \023\024)Tj /Span<>> BDC ( )Tj EMC [(Cl)-15.9(av)-16(ien\226Dind)-16(o \026\030\036\020\017)]TJ 0 Tw (-)Tj 0.059 Tw T* [(\f\021\030\017\030\024\r\026\027\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 5.815 0 Td [(\024\007\027\024\020\024 )0.5(\023\026\006\017\036\027\021\026)]TJ /Span<>> BDC ( )Tj EMC 7.27 0 Td [(\227 )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )]TJ -0.009 Tw -13.085 -1.218 Td (\022\024\035\024\026\027\026\035\034\027\024\020\024 \026\027\026\f\021\024\ \n\024\026 \023\024\f\035\036 \035\026\023\026\030\024\f\022\024\023\017\ \004\036\f\022\024\005 )Tj 0.052 Tw T* (\002\030\033\001\027\024-\026\027\026\035\034\027\024\005 \030\036\036\022\ \006\017\017 \023\030\016\n\024\005 \022\017\001\022\017, \017\035\036\024\ \f\021\024)Tj 0 Tw (-)Tj 0.177 Tw T* (\n\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\221\024\030\027\002\024\035\035\031. \215\026\006\017\036\027\021\031 \r\ \t\023\024\035\027\036\027\024 \023\024\r\021\024\030\027\024\036 )Tj 0.076 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \030\036\035\026\023\026\030\024\021\024)Tj 0 Tw (-)Tj 0.061 Tw T* (\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\024\002\013\036\027\017\016 \022\024\035\024\026\027\026\035\034\ \027\024\020\024 \026\027\026\f\021\024\n\024\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (8-\036 )Tj 0 Tw T* (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 420.3798 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.02 Tw 10 0 0 10 70.8661 396.0238 Tm (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\036\r \220\235\235\036\022\021\017\r\027\024\ \f\021\017 \027\036\024\026\007\255\033\r\026\027\021\027\024\005 )Tj 0.31 Tw T* [(\021\036\030\026\023\017\017 \016\r\035\016\036\021\f\016 )0.5(\f\021\036\023\036\027\034 \035\036\004\036\002\027\024\020\024 \023\026\ \021\024\n\024\030\235\024\026 )]TJ 0.071 Tw T* (\024\023\031\b\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036, \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \023\024\035\027\t\b \022\035\017\027\017\004\ \036\f\022\017\b )Tj 0.148 Tw T* (\024\021\r\036\021\024\r \024\023\031\b\024\035\017. \221\026\022, \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \017\f\f\035\036\007\024\r\026\027\ \017\016 )Tj 0.056 Tw T* (Habr-Gama \202., \023\024\f\035\036 \023\030\024\r\036\007\036\027\017\016\ \023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\024 )Tj 0.02 Tw T* (\022\031\030\f\026 \027\036\024\026\007\255\033\r\026\027\021\027\024\005\ \216\214\221, 10-\035\036\021\027\016\016 \r\t\032\017\r\026\036\n\024\f\ \021\034 )Tj 0.122 Tw T* [(\007\024\f\021\017\020\035\026 )0.5(97,7%, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 7.793 0 Td (\002\036\030\036\006\017\007\017\r\027\026\016)Tj /Span<>> BDC ( )Tj EMC 6.682 0 Td [(\227 )0.5(84%. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.739 0 Td (\220\021\024\n )Tj 0.609 Tw -20.215 -1.218 Td (\004\026\f\021\024\021\026 \023\024\035\027\t\b \022\035\017\027\017\004\ \036\f\022\017\b \024\021\r\036\021\024\r \f\024\f\021\026\r\017\035\026\ )Tj 0 Tw T* (26,8% [9].)Tj 0.469 Tw T* [(\200 )0.5(\n\031\035\034\021\017\006\036\027\021\030\024\r\024\n )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n )0.6(\017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj 0.383 Tw T* [(\r\026\027\017\017 S)-21(TELL)-34.9(AR \024\021\030\026\032\036\027\t \030\036\031\035\034\021\026\021\t \023\ \030\017\n\036\027\036\027\017\016 )]TJ 0.302 Tw T* [(\021\024\021\026\035\034\027\024\005 )0.6(\027\036\024\026\007\255\033\r\026\027\021\027\024\005 )0.6(\021\036\030\026\023\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.08 0 Td [(\030\036\032\017\n\036 )0.5(\022\024)]TJ 0 Tw (-)Tj 0.336 Tw -17.08 -1.218 Td [(\030\024\021\022\024\020\024 \022\031\030\f\026 )0.5(\022\030\031\023\027\024\235\030\026\022\006\017\024\027\027\024\005 \214\ \221 )0.5(\222\210\212 25 )0.5(\206\030 )]TJ 0.06 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ \021\036\030\026\023\017\036\005: \004\026\f\021\024\021\026 \023\024\035\ \027\t\b )Tj 0.115 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \024\021\r\036\021\024\r \f\024\ \f\021\026\r\017\035\026 11,1% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221, )Tj 0.273 Tw T* (\021\024\020\007\026 \022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \023\030\024\035\024\027\020\017\030\ \024\r\026\027\027\024\005 \216\214\221 )Tj 0 Tw T* (\222\210\212 50)Tj /Span<>> BDC ( )Tj EMC (\206\030)Tj /Span<>> BDC ( )Tj EMC (\227 4,4% [10].)Tj 0.132 Tw T* (\222 \006\036\035\034\033 \024\006\036\027\022\017 \024\021\r\036\021\026\ \024\023\031\b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\036 )Tj 0.173 Tw T* (\035\036\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \023\024\035\027\024\020\024 \022\035\017\ \027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026 )Tj 0.006 Tw T* (\(cCR\) \024\023\031\b\024\035\017 \023\030\017\n\036\027\016\033\021: \023\ \026\035\034\006\036\r\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj -0.104 Tw T* (\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\026\020\027\017\021\027\024-\030\036\024\027\026\ \027\f\027\024\005 \021\024)Tj 0 Tw (-)Tj -0.005 Tw T* (\n\024\020\030\026\235\017\017 \(\204\217\221\) \024\030\020\026\027\024\ \r \n\026\035\024\020\024 \021\026\026. \222\024\004\036\021\026\027\017\ \036 \220\021\017\b )Tj 0.104 Tw T* (\021\030\036\b \n\036\021\024\007\024\r \017\f\f\035\036\007\024\r\026\027\ \017\016 \023\024\r\024\035\016\036\021 \f\023\030\024\020\027\024\017\ \030\024)Tj 0 Tw (-)Tj 0.172 Tw T* (\r\026\021\034 \024\021\f\031\021\f\021\r\017\036 \024\f\021\026\021\024\ \004\027\024\005 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (98% \f\035\031\004\026\036\r )Tj 0.076 Tw T* ([11]. \221\026\022, \024\030\017\036\027\021\017\030\024\n \007\035\016 \ \023\024\f\021\026\027\024\r\022\017 cCR \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034)Tj 0 Tw (-)Tj 0.307 Tw T* (\006\036\r\024\n \030\036\022\021\026\035\034\027\024\n \017\f\f\035\036\ \007\024\r\026\027\017\017 \016\r\035\016\036\021\f\016 \020\035\026\007\ \022\026\016 )Tj 0.464 Tw T* (\f\035\017\017\f\021\026\016 \024\002\024\035\024\004\022\026 \023\030\016\ \n\024\005 \022\017\001\022\017 \017\035\017 \027\026\035\017\004\017\036\ )Tj -0.01 Tw 23.244 64.543 Td (\n\016\020\022\024\020\024, \220\035\026\f\021\017\004\027\024\020\024 \030\ \031\002\006\026. \233\027\007\024\f\022\024\023\017\004\036\f\022\017\n\ \022\030\017\021\036)Tj 0 Tw (-)Tj 0.029 Tw T* (\030\017\036\n \023\024\035\027\024\020\024 \022\035\017\027\017\004\036\ \f\022\024\020\024 \024\021\r\036\021\026 \024\023\031\b\024\035\017 \016\ \r\035\016\036\021\f\016 )Tj 0.207 Tw T* (\023\035\024\f\022\017\005, \002\036\035\036\f\024\r\026\021\t\005 \030\031\ \002\036\006 \002\036 \017\255\016\r\035\036\027\017\016, \r\024)Tj 0 Tw (-)Tj 0.224 Tw T* [(\n\024\032\027\024 )0.5(\027\026\035\017\004\017\036 )0.6(\021\036\035\036\026\027\020\017\024\220\022\021\026\017\005 )0.6([12]. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC 18.943 0 Td (\007\026\027\027\t\n )Tj 0.095 Tw -18.943 -1.218 Td (\204\217\221 \023\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\ \005 \024\021\r\036\021 \b\026\030\026\022\021\036\030\017\031\036\021\f\ \016 \027\026)Tj 0 Tw (-)Tj 0.016 Tw T* (\035\017\004\017\036\n \030\031\002\006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \030\026\027\036\036 \030\026\f\023\024\035\026\ \020\026\r\001\036\005\f\016 \024\023\031)Tj 0 Tw (-)Tj 0.104 Tw 0 -1.218 TD (\b\024\035\017, \027\036 \024\020\030\026\027\017\004\017\r\026\033\013\017\ \n \007\017\235\235\031\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\2212, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.246 Tw 0 -1.218 TD (\024\021\f\031\021\f\021\r\017\036\n \r\017\031\026\035\034\027\024 \017\ \n\036\027\036\027\027\t\b \035\017\n\235\026\021\017\004\036\f\022\017\ \b )Tj 0 Tw T* (\031\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\024\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\004\ \026\021\022\036 [13].)Tj 0.213 Tw T* (\200 \023\030\024\r\036\007\036\027\027\024\n \027\026\n\017 \030\026\027\ \007\024\n\017\017\030\024\r\026\027\027\024\n \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj 0.149 Tw T* [(\r\026\027\017\017, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\017 )0.5(\221\203\221 \f)]TJ /Span<>> BDC ( )Tj EMC 12.469 0 Td [(\023\030\017\n\036\027\036\027\017\036\n )0.5(\022\024\030\024\021\022\024)]TJ 0 Tw (-)Tj 0.287 Tw -12.469 -1.218 Td (\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\024 \022\031\ \030\f\024\r \214\221, \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.046 Tw T* (\027\026\004\017\n\t\b \030\026\035\017\004\017\005 \022\026\022 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \004\026\f\021\024\021\t \023\024\035\027\t\b \ )Tj 0.053 Tw T* [(\022\035\017\027\017\004\036\f\022\017\b, )0.6(\021\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.143 0 Td [(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.6(\024\021\r\036\021\024\r )0.5(\027\036 )]TJ 0.148 Tw -8.143 -1.218 Td (\023\024\035\031\004\036\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\ \035\034\021\026\021\t \035\036\004\036\027\017\016 )Tj 0 Tw T* (\f\024\023\024\f\021\026\r\017\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b.)Tj 0.211 Tw T* (\221\024\021\026\035\034\027\026\016 \027\036\024\026\007\255\033\r\026\027\ \021\027\026\016 \021\036\030\026\023\017\016 \024\021\022\030\t\r\026\036\ \021 \r\024)Tj 0 Tw (-)Tj -0.009 Tw T* (\n\024\032\027\024\f\021\017 \007\035\016 \007\017\027\026\n\017\004\036\ \f\022\024\020\024 \027\026\002\035\033\007\036\027\017\016 \023\026\006\ \017\036\027\021\024\r )Tj 0.056 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\t\n )0.5(\022\035\017\027\017\004\036\f\022\017\n )0.5(\024\021\r\036\021\024\n \017)]TJ /Span<>> BDC ( )Tj EMC [(\r )0.5(\030\016\007\036 )0.5(\f\035\031\004\026\036\r \023\024)]TJ 0 Tw (-)Tj 0.18 Tw T* [(\r\024\035\016\036\021 \017\002\036\032\026\021\034 \b\017\030\031\030\ \020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016, \023\030\017\007\036\030)]TJ 0 Tw (-)Tj 0.096 Tw T* (\032\017\r\026\016\f\034 \f\021\030\026\021\036\020\017\017 \027\026\002\ \035\033\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\027\017\016 [14,15]. )Tj 0.015 Tw T* (\222\035\036\007\031\036\021 \026\n\036\021\017\021\034, \004\021\024 \007\ \026\027\027\026\016 \f\021\030\026\021\036\020\017\016 \016\r\035\016\036\ \021\f\016 \220\022\f)Tj 0 Tw (-)Tj 0.114 Tw T* [(\023\036\030\017\n\036\027\021\026\035\034\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.035 0 Td [(\023\030\017\n\036\027\017\n\026 )0.6(\021\024\035\034\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.891 0 Td (\f\023\036\006\017\026\035\017\017)Tj 0 Tw (-)Tj 0.228 Tw -16.926 -1.218 Td [(\030\024\r\026\027\027\t\b \n\036\007\017\006\017\027\f\022\017\b )0.5(\031\004\030\036\032\007\036\027\017\016\b, \026)]TJ /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\024\n )Tj 0.07 Tw T* [(\035\036\004\036\027\017\016 )0.6(\030\026\022\026 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\024\f\021\026\036\021\f\016 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\036 )]TJ 0.168 Tw T* [(\035\036\004\036\027\017\036, )0.6(\026\004\026\f\021\031\033 )0.5(\f\024\023\030\024\r\024\032\007\026\033\013\036\036\f\016 )0.6(\027\036\024\002\b\024\007\017\n\024)]TJ 0 Tw (-)Tj T* (\f\021\034\033 \235\024\030\n\017\030\024\r\026\027\017\016 \022\017\001\ \036\004\027\024\005 \f\021\024\n\t.)Tj 0.416 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016, \026\022\021\031\ \026\035\034\027\t\n \024\f\021\026\036\021\f\016 \r\024\023\030\024\f )Tj 0.337 Tw T* (\024\023\030\036\007\036\035\036\027\017\016 \022\026\021\036\020\024\030\ \017\017 \023\026\006\017\036\027\021\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\024)Tj 0 Tw (-)Tj 0.185 Tw T* (\f\035\036 \023\030\024\r\036\007\036\027\017\016 \221\203\221 \f\035\036\ \007\031\036\021 \024\032\017\007\026\021\034 \023\024\035\027\024\020\024\ \022\035\017)Tj 0 Tw (-)Tj 0.242 Tw T* (\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n Guid)42.1(a A.M. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., )Tj 0.441 Tw T* (\027\026\017\002\024\035\036\036 \r\026\032\027\t\n\017 \023\030\024\020\ \027\024\f\021\017\004\036\f\022\017\n\017 \235\026\022\021\024\030\026\n\ \017, )Tj 0.507 Tw T* (\017\f\023\024\035\034\031\033\013\017\n\017\f\016 \007\035\016 \024\006\ \036\027\022\017 \023\030\024\020\027\024\026 \023\024\035\027\024\020\024\ )Tj 0.449 Tw T* [(\030\036\020\030\036\f\f\026 \024\023\031\b\024\035\017, \016\r\035\016\033\ \021\f\016: )0.5(\022\035\017\027\017\004\036\f\022\026\016 \f\021\026\007\017\016 )]TJ 0.055 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 TNM, \220\022\f\021\030\ \026\n\031\030\026\035\034\027\026\016 \f\024\f\031\007\017\f\021\026\016\ )Tj 0.127 Tw T* (\017\027\r\026\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024\021\036\027\006\017\026\035\034\027\024\036\ \r\024\r\035\036\004\036\027\017\036 \006\017\030\022\031)Tj 0 Tw (-)Tj 0.201 Tw T* [(\035\016\030\027\024\020\024 )0.5(\022\030\026\016 \030\036\036\022\006\017\017 )0.5([16]. \222\035\036\007\031\036\021 )0.5(\026\n\036\021\017\021\034, )0.5(\004\021\024 )]TJ 0.196 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \022\030\031\023\027\t\b \030\026\027\007\024\n\017\017\ \030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017)Tj 0 Tw (-)Tj 0.107 Tw T* [(\016\b, \022\026\022 RAPIDO [4], P)10(ol)-31(ishII [17], K)20(CSGC)13(O 14-03 [18], )]TJ 0.05 Tw T* [(W)31(AIT [19], PRODIGE-23 [20], \f\021\026\021\017\f\021\017\004\036\f\022\017\ \027\026\004\017\n\t\b )]TJ 0.431 Tw T* (\030\026\035\017\004\017\005 \024\021\027\024\f\017\021\036\035\034\027\ \024 \022\035\017\027\017\004\036\f\022\024\005 \f\021\026\007\017\017 \024\ \023\031)Tj 0 Tw (-)Tj 0.108 Tw T* (\b\024\035\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \024\021\r\036\021\024\n, \027\036 \002\t\035\024 )Tj 0.405 Tw T* (\023\024\035\031\004\036\027\024. \203\026\035\017\004\017\036 \017\027\r\ \026\017\017 \220\022\f\021\030\026\n\031\030\026\035\034\027\t\b \f\024\ )Tj 0 Tw (-)Tj 0.164 Tw T* (\f\031\007\024\r \024\006\036\027\017\r\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 RAPIDO, \024\007\027\026\022\024\ )Tj 0.066 Tw T* (\036\201 \f\r\016\034 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\024\n \024\023\031\b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\221\203\221 \027\036 \002\t\035\026 \017\031\004\036\027\026. )Tj -0.029 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \023\024\035\031\004\036\027\027\t\b \027\026\n\ \017 \007\026\027\027\t\b, \f\030\036\007\017 \023\030\036\007\017\022)Tj 0 Tw (-)Tj 0.03 Tw T* (\021\024\030\024\r \023\024\035\027\024\020\024 \024\021\r\036\021\026 \024\ \023\031\b\024\035\017 \r\t\016\r\035\036\027\t \020\035\031\002\017\027\ \026 \017\027)Tj 0 Tw (-)Tj -0.034 Tw T* (\r\026\017\017 \023\036\030\r\017\004\027\024\005 \024\023\031\b\024\035\ \017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\021\026\021\031\f \035\017\n\235\024\031\035\024\ \r )Tj 0 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016.)Tj 0.486 Tw T* (\230\f\f\035\036\007\031\036\n\t\036 \030\036\032\017\n\t \021\024\021\026\ \035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\027\024\005\ )Tj 0.069 Tw T* (\021\036\030\026\023\017\017 \f\024\023\024\f\021\026\r\017\n\t \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\ \t\b )Tj 0.232 Tw T* [(\030\036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n, \022\026\022 \022\024\030\024\021\022\017\005 )Tj 0.019 Tw T* (\022\031\030\f \214\221, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\026\016 \216\214\221\ \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031)Tj 0 Tw (-)Tj -0.023 Tw T* [(\033\013\036\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\036\005 )0.6(\n\024\020\031\021 )0.5(\023\030\017\n\036\027\016\021\034\f\016 )0.6(\007\035\016 )0.5(\035\036\004\036\027\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7653 56.0378 Tm (122)Tj ET endstream endobj 777 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-10(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ \026)11(\004\005\017\224\n\n \b\022\020\004\225\004\t\n\n \005\017\r\017 )]TJ 0 -1 TD [(\224\005\213\024\025\221 \r\n\204\r\n: \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 42.014 1 Td [(Ef)-31(f)-21(icacy of\022total neoadju)10(v)10(ant th)11(er)21.1(apy for r)31(ectal )]TJ 4.252 -1 Td [(cancer: r)31.1(esults of\022a\022r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.065 Tw 10 0 0 10 42.5197 432.5579 Tm (\(26,5%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\035\024\027\020\017\030\024\r\026\027\ \027\024\005 \216\214\221 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.065 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\) )Tj 0 Tw 0 -1.218 TD (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.234 Tw T* (\222\024\023\024\f\021\026\r\017\n\t \024\022\026\026\035\017\f\034 \030\ \036\031\035\034\021\026\021\t \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 )Tj 0.068 Tw T* (\035\036\004\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \024\021\030\017\006\026\021\036\035\034\027\t\ \b \020\030\026\027\017\006 \030\036\036\022\006\017\017, )Tj -0.029 Tw T* (\022\026\004\036\f\021\r\031 \n\036\024\030\036\022\021\031\n\220\022\021\ \024\n\017\017, \f\021\036\023\036\027\017 \024\021\r\036\021\026 \024\023\ \031\b\024\035\017 )Tj 0.216 Tw 23.244 4.871 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\027\036\024\026\007\255\033\r\026\027\021\027\024\036 )0.5(\035\036\004\036\027\017\036 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\n )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\016\n \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.238 Tw T* (\200 \f\021\030\031\022\021\031\030\036 \024\f\035\024\032\027\036\027\017\ \005 \f\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\ \024 \024\f)Tj 0 Tw (-)Tj 0.621 Tw T* (\035\024\032\027\036\027\017\016 I-II \f\021\036\023\036\027\017 \023\024\ )Tj /Span<>> BDC ( )Tj EMC [(Cl)-16(av)-16(ien\226Dind)-16(o \002\t\035\017 )]TJ 1.543 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\t \023\026\030\036\024\n \032\036\ \035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024 )Tj ET q 42.52 122.57 368.504 243.183 re W n q /GS0 gs 368.5039142 0 0 243.1885765 42.5196833 122.5642987 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.029 Tw 9 0 0 9 42.5197 111.7701 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\202\032\022\021\013\027 )0.6(\202\020\033\f\020\025\020-\215\020\235\027\032\020 )0.6(\033\031)]TJ /Span<>> BDC ( )Tj EMC 16.641 0 Td [(\023\032\027\200\f\027\023\025\027\235 )0.6(\240\027\016\032\027\006\022\030\022\021\025\031\235 )0.7(\021\013\255\022\021\020\027\026\031\024\023\022 )0.6(\033\031)]TJ /Span<>> BDC ( )Tj EMC 19.696 0 Td [(\b\032\r\033\033\020\026 )0.6(\n\031\032\031\023\n\031\b\031 )0.5(\n\r\032\024\020 )0.6(\f\r\007\027\021\031\235 )]TJ 0 Tw -36.338 -1.2 Td (\023\027\032\020\033\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\f\031\025\b\022\032\031\021\020\025\025\031\235 \225\035)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.068 Tw 0 -1.2 TD [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( K)17(aplan-Mayer cur)-41.9(v)12.9(es for three-year disease-free sur)-42(viv)16(al among g)14(roups with shor)-40(t-course radiation therap)12(y and long-)]TJ 0 Tw T* [(course chemoradio)13.2(therap)12(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \232\020\024\023\031\023\020 \033\031\f\025\013\200 \031\023\021\027\023\ \031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.323 0 Td [( R)5.7(a)-9.2(t)-1.5(e o)4(f c)2.8(o)-4(m)-1(p)-4.9(le)-8.6(t)-1.6(e r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)3.7(s)0.5(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.1809 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 224.187 715.1809 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 715.1809 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 715.1809 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1117 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 694.1117 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 694.1117 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 694.1117 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 682.6504 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 682.6504 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 682.6504 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 682.6504 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1891 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 671.1891 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 671.1891 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 671.1891 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.7278 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 659.7278 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 659.7278 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 659.7278 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 648.2665 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 224.187 648.2665 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 648.2665 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 450.9586 648.2665 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 116.7386 701.7463 Tm (\200\004\006\004\214\r\003\006)Tj 15.8 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 10.861 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_4 1 Tf 11.494 0.6 Td (\t)Tj /T1_1 1 Tf -53.244 -2.033 Td (pCR)Tj 26.729 0 Td (9/53)Tj /Span<>> BDC ( )Tj EMC (\(14,7%\))Tj 14.423 0 Td (6/51)Tj /Span<>> BDC ( )Tj EMC (\(9,3%\))Tj 11.759 0 Td (0,6)Tj -52.911 -1.433 Td (cCR \(\n\036\007\017\026\027\026 \023\030\024\f\035\036\032\036\027\027\024\ \f\021\017, \n\036\f\016\006\036\r: 18)Tj /Span<>> BDC ( )Tj EMC (\(3-35\)\) )Tj 27.701 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj 13.673 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(17,2%\))Tj 11.287 0 Td (0,18)Tj -52.661 -1.433 Td (\217\036\006\017\007\017\r \023\024\f\035\036 \023\024\035\027\024\020\024\ \022\035\017\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026)Tj 27.322 0 Td (4/9)Tj /Span<>> BDC ( )Tj EMC (\(44%\))Tj 13.923 0 Td (5/16)Tj /Span<>> BDC ( )Tj EMC (\(31%\))Tj 11.666 0 Td (0,7)Tj -52.911 -1.433 Td (\210\002\013\026\016 \004\026\f\021\024\021\026 \023\024\035\027\t\b \024\ \021\r\036\021\024\r)Tj 27.201 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(22,9%\))Tj 14.173 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(26,5%\))Tj 11.537 0 Td (0,6)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 631.5473 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \200\022\032\r\032\b\022\007\027\024\ \n\031\b\031 \f\027\007\027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.002 Tc -0.002 Tw 3.329 0 Td [( R)4.8(e)-20(s)8.7(u)0.5(l)7.2(t)-30.9(s)2.1( o)6(f)]TJ /Span<>> BDC 4.088 0 Td ( )Tj EMC [(s)8.7(u)3.6(rg)-16.7(ic)5.2(a)-2.4(l)2( t)-7.6(re)-5.5(a)-7.2(t)-8.6(m)-3.3(e)-5(n)1.4(t)]TJ ET /GS2 gs q 1 0 0 1 42.5197 616.2453 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 201.5098 616.2453 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 269.5413 616.2453 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 360.25 616.2453 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 616.2453 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 595.1761 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 583.7148 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 595.1761 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 595.1761 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 595.1761 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 595.1761 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.7148 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 572.5035 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 583.7148 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 583.7148 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 583.7148 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 572.5035 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 572.2535 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 560.7922 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 572.2535 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 572.2535 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 572.2535 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 572.2535 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 560.7922 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 549.3309 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 560.7922 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 560.7922 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 560.7922 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 549.3309 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 538.1197 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 549.3309 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 549.3309 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 549.3309 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 538.1197 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 537.8697 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 526.4084 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 537.8697 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 537.8697 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 537.8697 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 537.8697 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 526.4084 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 514.9471 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 526.4084 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 526.4084 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 526.4084 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 514.9471 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 503.4858 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 514.9471 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 514.9471 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 514.9471 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 503.4858 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 492.2745 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 503.4858 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 503.4858 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 503.4858 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 492.2745 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 492.0245 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 480.5632 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 492.0245 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 492.0245 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 492.0245 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 492.0245 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 480.5632 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 469.102 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 480.5632 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 480.5632 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 480.5632 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 469.102 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 457.8907 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 469.102 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 469.102 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 469.102 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 457.8907 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 457.6407 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 201.5098 457.6407 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 269.5413 457.6407 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 457.6407 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 450.9586 457.6407 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 139.4158 602.8107 Tm (\200\004\006\004\214\r\003\006)Tj 17.217 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (54\))Tj 8.027 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_4 1 Tf 10.076 0.6 Td (\t)Tj /T1_1 1 Tf -53.244 -2.033 Td (\206\030\026\027\017\006\t \030\036\036\022\006\017\017)Tj 23.227 0 Td (R0)Tj 8.569 0 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(91%\))Tj 11.339 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(92%\))Tj 9.777 0 Td (1,0)Tj -29.685 -1.433 Td (R1)Tj 9.069 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 11.339 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj -43.634 -1.433 Td (\025\026\004\036\f\021\r\024 \n\036\024\030\036\022\021\031\n\220\022\021\ \024\n\017\017)Tj 22.083 0 Td (Quirke 1)Tj 9.713 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(19%\))Tj 11.589 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.527 0 Td (0,5)Tj -30.829 -1.433 Td (Quirke 2)Tj 9.963 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(15%\))Tj 11.339 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj -21.301 -1.433 Td (Quirke 3)Tj 9.713 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(66%\))Tj 11.339 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(76%\))Tj -43.134 -1.433 Td (\222\021\036\023\036\027\034 \024\021\r\036\021\026 \024\023\031\b\024\035\ \017 \023\024)Tj /Span<>> BDC ( )Tj EMC (Ryan)Tj 23.49 0 Td (0)Tj 8.555 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17%\))Tj 11.339 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.527 0 Td (0,6)Tj -29.421 -1.433 Td (1)Tj 8.555 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(15%\))Tj 11.089 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(25%\))Tj -19.644 -1.433 Td (2)Tj 8.305 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(47%\))Tj 11.339 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(47%\))Tj -19.644 -1.433 Td (3)Tj 8.305 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(21%\))Tj 11.589 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj -43.384 -1.433 Td 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\r\t\016\r\035\036\027\026 \031)]TJ /Span<>> BDC ( )Tj EMC (2% \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \207 \(\216\214\221\), )Tj -0.037 Tw 0 -1.218 TD (\021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\(\214\221\))Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (9% \023\026\006\017\036\027\021\024\r \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.193 Tw 0 -1.218 TD (\222\030\036\007\017 125 \023\026\006\017\036\027\021\024\r, \r\022\035\033\ \004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036, )Tj 0.009 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (25 \(20%\) \002\t\035 \007\017\026\020\027\024\f\021\017\030\024\r\026\027\ \023\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\005 )Tj 0.211 Tw 0 -1.218 TD [(\024\021\r\036\021. )0.5(\230)]TJ /Span<>> BDC ( )Tj EMC 4.437 0 Td [(\027\017\b )0.5(9/61 )0.5(\(15%\) )0.6(\023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.928 0 Td [(\020\030\031\023\023\036 )0.5(\202)]TJ /Span<>> BDC ( )Tj EMC 4.227 0 Td (\017 )Tj 0 Tw -21.592 -1.218 Td (16/64 \(25%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.064 Tw 0 -1.218 TD (\215\030\017 \023\030\024\f\035\036\032\036\027\027\024\f\021\017 \024\021\ 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (35 \n\036\f\016\006\036\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 )Tj 0.177 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (18 \n\036\f\016\006\036\r, \004\026\f\021\024\021\026 \023\024\035\027\t\ \b \022\035\017\027\017\004\036\f\022\017\b \024\021\r\036\021\024\r )Tj 0.131 Tw 0 -1.218 TD (\f\024\f\021\026\r\017\035\026 5/61 \(8,2%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 \022\031\030\ \f\026 \214\221 )Tj 0.321 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (11/64 \(17,2%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\035\024\027\020\017\030\024\r\026\027\ \027\024\005 \216\214\221 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf 0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\). \211)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\(36%\) \017)Tj /Span<>> BDC ( )Tj EMC (25 \023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \007\017\ \026\020)Tj 0 Tw (-)Tj 0.276 Tw 0 -1.218 TD (\027\024\f\021\017\030\024\r\026\027 cCr \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\035\024\032\036\027\026 \021\026\022\021\017\022\026 \253\ w)-12(a)15(tch and )]TJ 0.198 Tw 0 -1.218 TD [(w)-12(ai)-24(t\273, \026\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \023\030\ \024\020\030\036\f\f\017\030\024\r\026\027\017\036 \026\002\024\035\036\ )]TJ 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\016 \()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7\).)Tj 0.094 Tw 0 -1.218 TD (\200 \020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \026\002\024\ \035\036\r\026\027\017\016 \007\017\026\020\027\024\f)Tj 0 Tw (-)Tj 0.028 Tw 0 -1.218 TD (\021\017\030\024\r\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (4 \f\035\031\004\026\016\b: \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\b \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\f\021\027\t\005 )Tj 0.175 Tw 0 -1.218 TD (\030\036\006\017\007\017\r, \036\013\036 \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\b)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\f\021\027\t\005 \030\036\006\017\007\017\r \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026)Tj 0 Tw (-)Tj 0.189 Tw 0 -1.218 TD (\035\036\027\027\t\036 \n\036\021\026\f\021\026\t. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207 \r\t\016\r\035\036\027\024 5 \f\035\031\004\ \026\036\r )Tj 0.125 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Tw T* (\020\030\036\f\f\017\030\024\r\026\027\017\016 \026\002\024\035\036\r\026\ \027\017\016. \221\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 )Tj 0.088 Tw 0 -1.218 TD (\022\031\030\f\026 \035\031\004\036\r\024\005 \021\036\030\026\023\017\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 10/61 \(16,3%\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 )Tj 0.166 Tw 0 -1.218 TD (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005 \216\214\221\ )Tj /Span<>> BDC ( )Tj EMC (\227 10/64 \(15,6%\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026)Tj 0 Tw (-)Tj 0.127 Tw 0 -1.218 TD [(\035\017\036 12-\n\036\f\016\004\027\024\005 )0.5(\002\036\030\036\006\017\007\017\r\027\024\005 \r\t\032\017\r\026\036\n\ \024\f\021\017)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.15 Tw -21.11 -1.218 Td (\r\036\030\024\016\021\027\024\f\021\034 \024\021\f\031\021\f\021\r\017\016\ \030\036\006\017\007\017\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026)Tj 0 Tw (-)Tj 0.104 Tw T* (\r\017\035\026 84,8% \(95% \212\230: 74,5\22696,4\), \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207)Tj /Span<>> BDC ( )Tj EMC (\227 96% )Tj 0.009 Tw 0 -1.218 TD (\(95% \212\230: 90,7\226100\). \204\036\007\017\026\027\026 \007\024\032\ \017\021\017\016 \007\024\f\021\017\020\027\031\021\026 \027\036 )Tj 0.173 Tw 0 -1.218 TD (\002\t\035\026, \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\024 \027\036 \030\026\035\017\004\026)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\035\017\f\034 \n\036\032\007\031 \f\024\002\024\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\006\017\007\017\r\027\024\005 \r\t\032\017\r\026\036\n\ \024\f\021\017 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,54\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.194 Tw 0 -1.218 TD [(\215\024 )0.5(\f\024\f\021\024\016\027\017\033 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.784 0 Td [(\027\024\016\002\030\034 )0.6(2025 )0.5(\020\024\007\026 )0.5(\023\024\007 )0.5(\007\017\027\026\n\017\004\036)]TJ 0 Tw (-)Tj 0.097 Tw -7.784 -1.218 Td (\f\022\017\n \027\026\002\035\033\007\036\027\017\036\n, \002\036 \023\030\ \017\027\026\022\024\r \r\024\r\030\026\021\026 \026\002\024\035\036)Tj 0 Tw (-)Tj 0.204 Tw 0 -1.218 TD (\r\026\027\017\016 \027\026\b\024\007\017\021\f\016 5/61 \(8,2%\) \023\026\ \006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t )Tj 0.219 Tw 0 -1.218 TD (\202, \017)Tj /Span<>> BDC ( )Tj EMC (11/64 \(17,2%\))Tj /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \207. \210\007\017\027 \023\026\006\017\036\027\021\ )Tj 0.019 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \202, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \007\017\026\020\027\024\f\021\017\030\024\ \r\026\027 \023\024\035\027\t\005 \022\035\017)Tj 0 Tw (-)Tj 0.297 Tw 0 -1.218 TD (\027\017\004\036\f\022\017\005 \024\021\r\036\021, \023\030\017\027\016\035\ \030\036\001\036\027\017\036 \r\024\007\036\030\032\026\021\034\f\016 \ \024\021 )Tj 0.162 Tw 0 -1.218 TD (\f\021\030\026\021\036\020\017\017 \027\026\002\035\033\007\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035 \024\023\036\030\017\030\024)Tj 0 Tw (-)Tj 0.05 Tw 0 -1.218 TD (\r\026\027)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024 \007\017\026\020\027\024\f\021\017\030\024\r\026\027 \023\ \024\035\027\t\005 \023\026\021\024\n\024\030\235\024\035\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\017\004\036\f\022\017\005 \024\021\r\036\021.)Tj 0.307 Tw 0 -1.218 TD [(\232\026\f\021\024\021\026 \023\024\035\027\t\b )0.5(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.5(\024\021\r\036\021\024\r \f\024)]TJ 0 Tw (-)Tj 0.2 Tw 0 -1.218 TD (\f\021\026\r\017\035\026 9/53 \(14,7%\) \023\030\024\021\017\r 6/51 \(9,\ 3%\), \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\). \210\002\013\026\016 \004\026\f\021\024\021\026 \023\024\035\027\t\ \b \024\021\r\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.109 Tw 0 -1.218 TD (14/61 \(22,9%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 \022\031\030\ \f\026 \214\221 \017)Tj /Span<>> BDC ( )Tj EMC (17/64 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8662 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \004\027\032\027\025\031\024\022\026\031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\023\031\n\024\022\007\025\031\024\023\017 \n\031\025\024\031\f\022\030\022\ \032\r\005\212\027\235 \200\022\026\022\031\023\027\032\020\033\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.337 0 Td [( T)41.8(o)-5.3(le)-5.9(r)3.3(a)-0.9(b)-1.1(i)2.9(li)-3.4(t)-33.8(y a)-5(n)-4.8(d t)-3(o)-4.1(x)-30(i)-1.8(c)-30.1(i)-3.3(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(n)3.7(s)0.6(o)-5.3(li)-1.4(d)-2.5(a)-9.2(t)-29.1(i)-1.4(o)-4(n c)-2.4(h)-2.4(e)-7(m)-5.3(o)-2.9(t)-10.6(h)-2.4(e)-6(r)3.3(a)-5.2(p)-3.4(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8662 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1162 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 394.2657 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 490.6437 715.181 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6595 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8662 694.1118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1162 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 694.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 694.1118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 682.6505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1162 671.1893 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.502 682.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 682.6505 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 671.1893 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 71.1162 659.978 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.252 671.1893 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 671.1893 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 671.1893 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 394.2657 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 659.978 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8662 659.728 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 659.728 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 659.728 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 659.728 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 490.6437 659.728 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 110.9372 701.7465 Tm (\021\006\t\003\r\006\t\005)Tj 14.136 0 Td (\022\r\213\210\f\001\003\004\003)Tj 10.539 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (58\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj /T1_3 1 Tf 9.722 0.6 Td (\t)Tj /T1_0 1 Tf -53.953 -2.033 Td (\215\036\030\036\027\024\f\017\n\024\f\021\034)Tj 16.88 0 Td (\211\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\024)Tj 15.27 0 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(82%\))Tj 12.047 0 Td (52)Tj /Span<>> BDC ( )Tj EMC (\(85%\))Tj 9.423 0 Td (0,8)Tj -53.62 -1.433 Td (\221\024\022\f\017\004\027\024\f\021\034)Tj T* (\(NCI-CTCAE\))Tj 18.371 1.2 Td (1\2262 \f\021\036\023\036\027\017)Tj 14.279 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 11.797 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13%\))Tj 8.923 0 Td (0,19)Tj -35 -1.433 Td (3\2264 \f\021\036\023\036\027\017)Tj 14.279 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 12.047 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj ET q /GS0 gs 453.543294 0 0 209.493808 70.8661499 101.0429351 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \221\f\031\n-\024\200\027\026\020 \032\020\024\033\032\027\030\027\f\027\ \025\022\t \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC [(\033\031\f\025\013\026 \n\f\022\025\022\007\027\024)0.5(\n\022\026 \031\023\021\027\023\031\026)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( P)18(atient allocation f)-21.8(low char)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(patients with clinical com)16.3(plete response)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (120)Tj ET endstream endobj 850 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;w    m!1AQSTUa"235qt#BR$4bs %&'()*6789:CDEFGHIJVWXYZcdefghijruvwxyz?QQpQ55 $FS4v)rсû9ha݊~朴`}0?sNZ0>wb-L;OӖاiFS4v)rсû9ha݊~朴`}0?sNZ0>wb. ,Y52NJQV$5VaV0+Ww 62-o#X׬wP^xk"xp$d4q,?cìi99н4vm$sEucʏ6(&8$pnCs̀7oaØng&fxn fuVlӕ$F AP'ҍ3i4N-7^ \*)c&M =9k`7A_U *p՘"""""""""""""""""""""""""" QV$5VaV4 aYR'su uD C0֭` c>h:2hp[™ıX~B"3lA$Y<5YBIZG@`xZ{M4n)2 F-v7<`u}6a+aU q"6|!UiJs\7f%jQV$5VaV%_DDDDDDDDDDDDDDDDDDDDDDDDDDDQlB+k8s5p wO% %4g$-gp˼KMG]8~''86b- -3>&ĭ_NU7O 49[ Ht3 :!)>匽JFpX]i6ڴNК:6{|ܯ7[{:I/g~19[p1O_'Ƨ!gO^ByY 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obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-10(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ \026)11(\004\005\017\224\n\n \b\022\020\004\225\004\t\n\n \005\017\r\017 )]TJ 0 -1 TD [(\224\005\213\024\025\221 \r\n\204\r\n: \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 42.014 1 Td [(Ef)-31(f)-21(icacy of\022total neoadju)10(v)10(ant th)11(er)21.1(apy for r)31(ectal )]TJ 4.252 -1 Td [(cancer: r)31.1(esults of\022a\022r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.482 Tw 10 0 0 10 42.5197 371.6679 Tm (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017 26.09.2022 \020\024\007\026.)Tj /T1_2 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.11 Tw 0 -1.218 TD (\222\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \023\030\024\r\024\007\017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \023\030\024)Tj 0 Tw (-)Tj 0.135 Tw T* [(\020\030\026\n\n\t S)15(t)15(a)15(t)-32(ist)-31.9(ica 13.3 \(TIBC)13(O, \222\231\202\) \017)]TJ /Span<>> BDC ( )Tj EMC [(RS)15(tudio \(R v. )]TJ -0.016 Tw T* [(4.4.1 \(R Cor)-23.9(e T)40(eam, \200\036\027\026, \202\r\f\021\030\017\016\)\). \215\030\024\r\036\030\ \022\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\027\024\030)Tj 0 Tw (-)Tj 0.249 Tw T* (\n\026\035\034\027\024\036 \030\026\f\023\030\036\007\036\035\036\027\017\ \036 \024\f\031\013\036\f\021\r\035\016\035\026\f\034 \022\030\017\021\036\ \030\017\036\n )Tj 0.403 Tw T* (\025\024\035\n\024\020\024\030\024\r\026\226\222\n\017\030\027\024\r\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\f \023\024\n\024\013\034\033 \r\017\031\026\035\034\027\024\005 )Tj -0.033 Tw T* [(\024\006\036\027\022\017 \020\017\f\021\024\020\030\026\n\n\t \030\026\f\ \023\030\036\007\036\035\036\027\017\016 )0.5(\004\026\f\021\024\021 \023\030\017\027\026\022\026. )]TJ 0.156 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \206\026\031\f\f\024\r\026 \030\026\f\023\030\036\ \007\036\035\036\027\017\016 \027\036\023\030\036\030\t\r\027\t\036 )Tj 0.179 Tw T* (\007\026\027\027\t\036 \024\023\017\f\t\r\026\035\017\f\034 \f\030\036\007\ \027\017\n\017 \027\026\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027)Tj 0 Tw (-)Tj 0.08 Tw T* (\007\026\030\021\027\t\n\017 \024\021\022\035\024\027\036\027\017\016\n\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD; \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b )Tj 0.226 Tw T* (\f\035\031\004\026\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\007\017\026\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\022\r\026\030\021\017\035\034\027\t\n \030\026\n\026\b\024\n\ )Tj -0.019 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 Me \(IQR\). \222\030\026\r\027\036\027\017\036 \020\030\031\ \023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\036\027\027\t\n )Tj 0.125 Tw T* [(\023\030\017\027\026\022\026\n )0.6(\r\027\036 )0.5(\026\r\017\f\017\n\024\f\021\017 )0.6(\024\021 )0.5(\b\026\030\026\022\021\036\030\026 )0.5(\030\026\f\023\030\036\007\036)]TJ 0 Tw (-)Tj 0.427 Tw T* (\035\036\027\017\016 \024\f\031\013\036\f\021\r\035\016\035\026\f\034 U-\ \022\030\017\021\036\030\017\036\n \204\026\027\027\026\226\211\017\021\027\ \017, )Tj 0.039 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\n)Tj /Span<>> BDC ( )Tj EMC (\227 \245)Tj 0 Tw 5.83 0 0 5.83 134.4544 167.9718 Tm (2)Tj 0.039 Tw 10 0 0 10 137.3694 164.6418 Tm ( \215\017\030\f\024\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\036\n\t\b \027\026)Tj 0 Tw (-)Tj 0.044 Tw -9.485 -1.218 Td (\004\036\027\017\016\b \002\024\035\036\036 10 \007\035\016 \r\f\036\b \016\ \004\036\036\022 \007\035\016 \004\036\021\t\030\036\b\023\024\035\034\027\ \t\b )Tj 0.199 Tw T* (\021\026\002\035\017\006 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 5)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036 \n\036\027\036\036 \004\036\n \007\035\016 20% \016\004\036\ \036\022 )Tj -0.022 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\023\024\035\034\027\t\b, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b \f\035\031\004\026\016\b \023\030\017\n\036\ \027\016\035\017 \007\r\031)Tj 0 Tw (-)Tj -0.06 Tw T* [(\f\021\024\030\024\027\027\017\005 )0.5(\021\024\004\027\t\005 \022\030\017\021\036\030\017\005 )0.5(\205\017\001\036\030\026. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \002\036)Tj 0 Tw (-)Tj -0.034 Tw T* (\030\036\006\017\007\017\r\027\024\005 \r\t\032\017\r\026\036\n\024\f\021\ \017 \r\t\f\004\017\021\t\r\026\035\017 \023\030\024\n\036\032\031\021\024\ \022 )Tj 0.145 Tw T* (\r\030\036\n\036\027\017 \024\021 \007\026\021\t \027\026\004\026\035\026\ \035\036\004\036\027\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\t \030\036\006\017\007\017\r\026 )Tj 0.451 Tw T* (\017\035\017 \023\024\f\035\036\007\027\036\020\024 \022\024\027\021\030\ \024\035\016. \210\006\036\027\022\026 \r\t\032\017\r\026\036\n\024\f\021\ \017 )Tj 0.429 Tw 23.244 29.227 Td (\023\030\024\r\024\007\017\035\026\f\034 \023\031\021\036\n \023\024\f\021\ \030\024\036\027\017\016 \022\030\017\r\t\b \025\026\023\035\026\027\026\ \226)Tj 0.034 Tw T* (\204\026\005\036\030\026, \f\030\026\r\027\036\027\017\036 \020\030\031\023\ \023 \024\f\031\013\036\f\021\r\035\016\035\017 \035\024\020\030\026\027\ \020\024\r\t\n )Tj 0.125 Tw T* (\021\036\f\021\024\n. \217\026\035\017\004\017\016 \f\004\017\021\026\035\ \017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\ \n\017 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 298.5999 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.017 Tw 10 0 0 10 274.9606 274.2439 Tm (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\004\036\027\ \t 125 \023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj -0.026 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 \022\031\030\ \f\026 \214\221)Tj /Span<>> BDC ( )Tj EMC (\227 61 \023\026\006\017\036\027\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 )Tj 0 Tw T* (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005 \216\214\221\ )Tj /Span<>> BDC ( )Tj EMC (\227 64 \023\026\006\017\036\027\021\026.)Tj -0.016 Tw T* (\206\030\031\023\023\t \002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031, \r\024\030\026\f\021\031, \030\026\n\036\030\031 )Tj -0.001 Tw T* (\024\023\031\b\024\035\017, \027\026\035\017\004\017\033 \017\035\017 \024\ \021\f\031\021\f\021\r\017\033 \r\024\r\035\036\004\036\027\017\016 \006\ \017\030\022\031)Tj 0 Tw (-)Tj 0.195 Tw T* (\035\016\030\027\024\020\024 \022\030\026\016 \030\036\036\022\006\017\017\ \017\035\017 \017\027\r\026\017\017 \220\022\f\021\030\026\n\031\030\026\ \035\034)Tj 0 Tw (-)Tj T* (\027\t\b \f\024\f\031\007\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016 \(\221\026\002\035\ . 1\).)Tj 0.059 Tw T* (\200 \024\002\036\017\b \020\030\031\023\023\026\b \023\024\035\031\004\036\ \027\t \f\024\023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034\021\026\ \021\t )Tj -0.025 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\026\036\027\021\027\024\f\021\017, \023\036\030\036\027\ \024\f\017\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\022\f\017\004\027\024\f\021\017 \035\031)Tj 0 Tw (-)Tj 0.08 Tw T* [(\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 )0.6(\(\221\026\002\035.)]TJ /Span<>> BDC ( )Tj EMC 9.286 0 Td [(2\). )0.5(\200\f\036 )0.5(\023\026\006\017\036\027\021\t )0.6(\023\030\024\001\035\017 )0.5(\023\024\035)]TJ 0 Tw (-)Tj 0.072 Tw -9.286 -1.218 Td (\027\t\005 \022\031\030\f \214\221/\216\214\221, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \021\024\022\f\017\004\027\024\f\021\034 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 )Tj 0.263 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 R)-12(T)19.9(OG \026\030\036\020\017\f\021\030\017\030\024\r\026\027\026 \031)]TJ /Span<>> BDC ( )Tj EMC (2% \023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\t.)Tj 0.126 Tw T* (\025\024\n\023\035\026\036\027\021\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\026)Tj 0 Tw (-)Tj -0.052 Tw T* (\004\017\n\024 \027\036 \030\026\035\017\004\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b. \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\n \023\030\017)Tj 0 Tw (-)Tj 0.003 Tw T* (\004\017\027\026\n \022\024\027\f\024\035\017\007\017\030\031\033\013\026\ \016 \b\017\n\017\024\021\036\030\026\023\017\016 \027\036 \002\t\035\026\ \023\030\024)Tj 0 Tw (-)Tj T* (\r\036\007\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (5% \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\t \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \b\032\r\033\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.002 Tc -0.002 Tw 3.324 0 Td [( C)0.9(h)2.4(a)-2.2(r)5.3(a)-7.2(c)-30.3(te)-4(r)-37(i)8.6(s)-12.8(t)-27.1(ic)-24.7(s)2( o)6.1(f)]TJ /Span<>> BDC 7.087 0 Td ( )Tj EMC [(g)0.5(ro)-1.4(up)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 195.8405 715.181 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 715.181 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 682.6505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.8405 694.1118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 195.8405 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 694.1118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.6505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 671.4392 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 682.6505 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 195.8405 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 682.6505 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4392 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 671.1892 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 195.8405 671.1892 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 671.1892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 671.1892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 671.1892 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 650.1279 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 195.8405 650.1279 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 650.1279 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 650.1279 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 650.1279 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 629.0667 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 617.6053 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.8405 629.0667 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 195.8405 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 629.0667 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 629.0667 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 629.0667 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 617.6053 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 606.394 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 617.6053 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 195.8405 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 617.6053 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 617.6053 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 606.394 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 606.144 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 594.6827 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.8405 606.144 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 195.8405 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 606.144 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 606.144 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 606.144 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 594.6827 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 583.4715 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 594.6827 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 195.8405 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 594.6827 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 594.6827 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.4715 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 583.2215 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 195.8405 583.2215 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 583.2215 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 583.2215 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 462.2972 583.2215 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_5 1 Tf 0 Tc 0 Tw 8 0 0 8 139.4158 701.7464 Tm (\200\004\006\004\214\r\003\006)Tj 17.571 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_2 1 Tf 9.722 0.6 Td (\t)Tj /T1_1 1 Tf -53.953 -2.033 Td (\215\024\035)Tj 22.501 0 Td (\204\031\032)Tj 9.649 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(59%\))Tj 12.047 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj 9.423 0 Td (0,3)Tj -31.13 -1.433 Td (\240\036\027)Tj 9.66 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(41%\))Tj 12.047 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj -44.197 -1.433 Td (\200\024\030\026\f\021, \035\036\021, \204)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD \(Min\226Max\) )Tj 31.848 0 Td (63,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,9)Tj 0.52 -1.2 Td (\(31\22680\))Tj 11.527 1.2 Td (62,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (11,4)Tj 0.52 -1.2 Td (\(29\22683\))Tj 9.205 1.2 Td (0,3)Tj -53.62 -2.633 Td (\217\026\n\036\030 \024\023\031\b\024\035\017, \n\n)Tj T* (\204\036 \(Q1\226Q3\))Tj 31.501 1.2 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(24\226123\))Tj 12.297 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(27\22676\))Tj 9.822 0 Td (0,4)Tj -53.62 -2.633 Td (\037\017\030\022\031\035\016\030\027\t\005 \022\030\026\005 \030\036\036\ \022\006\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016)Tj 22.305 0 Td (CRM+)Tj 9.844 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(51%\))Tj 12.047 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(52%\))Tj 9.423 0 Td (0,9)Tj -31.343 -1.433 Td (CRM\226)Tj 9.872 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(49%\))Tj 12.047 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(48%\))Tj -44.197 -1.433 Td (\230\027\r\026\017\016 \220\022\f\021\030\026\n\031\030\026\035\034\027\ \t\b \f\024\f\031\007\024\r )Tj 0 -1.2 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016)Tj 22.124 1.2 Td (EMVI+)Tj 10.026 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(38%\))Tj 12.047 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(36%\))Tj 9.423 0 Td (0,8)Tj -31.524 -1.433 Td (EMVI\226)Tj 10.054 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(62%\))Tj 12.047 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(64%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 566.5022 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \033\032\031\021\027\030\027\025\022\ \t \f\r\007\027\021\031\235 \023\027\032\020\033\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf -0.003 Tc 0.003 Tw 3.334 0 Td [( Re)-25(s)3.7(u)-4.6(l)2.3(t)-35.9(s)-3( o)1(f)]TJ /Span<>> BDC 4.088 0 Td ( )Tj EMC [(ra)-11.7(d)-6(i)-1.5(a)-12.2(t)-32.1(i)-4.4(o)-6.9(n)-3( t)-13.6(h)-5.4(e)-9(ra)-8.2(p)-6.4(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 551.2003 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 551.2003 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 269.5413 551.2003 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 551.2003 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 551.2003 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 530.131 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 530.131 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 530.131 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 530.131 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 530.131 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 518.6697 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 518.6697 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 518.6697 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 518.6697 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 518.6697 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 507.2085 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 495.7472 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 156.1555 507.2085 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 507.2085 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 507.2085 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 507.2085 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 495.7472 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 484.5359 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 155.9055 495.7472 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 495.7472 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 495.7472 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 484.5359 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 484.2859 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 484.2859 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 484.2859 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 484.2859 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 462.2972 484.2859 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_5 1 Tf 0 Tc 0 Tw 8 0 0 8 82.5907 537.7657 Tm (\021\006\t\003\r\006\t\005)Tj 14.136 0 Td (\022\r\213\210\f\001\003\004\003)Tj 10.539 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_2 1 Tf 9.722 0.6 Td (\t)Tj /T1_1 1 Tf -53.953 -2.033 Td (\025\024\n\023\035\026\036\027\021\027\024\f\021\034)Tj 16.662 0 Td (\211\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\026\016)Tj 15.238 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 12.047 0 Td (64)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 9.988 0 Td (\226)Tj -53.935 -1.433 Td (\215\036\030\036\027\024\f\017\n\024\f\021\034)Tj 16.662 0 Td (\211\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\026\016)Tj 15.488 0 Td (59)Tj /Span<>> BDC ( )Tj EMC (\(96%\))Tj 12.047 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(94%\))Tj 9.423 0 Td (0,7)Tj -53.62 -1.433 Td (\221\024\022\f\017\004\027\024\f\021\034 \(RTOG\))Tj 18.371 0 Td (1\2262 \f\021\036\023\036\027\017)Tj 14.279 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 12.047 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 8.923 0 Td (0,8)Tj -35.25 -1.433 Td (3\2264 \f\021\036\023\036\027\017)Tj 14.279 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 12.047 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 467.5666 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \202\031\026\033\f\020\027\025\023\025\031\024\023\017 \n)Tj /Span<>> BDC ( )Tj EMC (\n\031\025\024\031\f\022\030\022\032\r\005\212\027\235 \200\022\026\022\031\ \023\027\032\020\033\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.318 0 Td [( C)1.2(o)-4(m)-1(p)-4.9(li)1.5(a)-5.1(n)-2.9(c)2.8(e w)-26.7(i)-3.4(t)-10.6(h c)2.9(o)-4(n)3.7(s)0.5(o)-5.3(li)-1.4(d)-2.5(a)-9.1(t)-29.2(i)4(n)-0.6(g c)-2.5(h)-2.4(e)-7(m)-5.3(o)-2.9(t)-10.6(h)-2.4(e)-6(r)3.4(a)-5.2(p)-3.4(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 452.2646 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 452.2646 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 269.5413 452.2646 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 452.2646 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 452.2646 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 431.1954 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 419.7341 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 156.1555 431.1954 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 431.1954 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 431.1954 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 431.1954 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 419.7341 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 408.2728 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 155.9055 419.7341 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 419.7341 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 419.7341 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 408.2728 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 397.0616 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 155.9055 408.2728 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 408.2728 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 408.2728 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 397.0616 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 396.8116 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 396.8116 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 396.8116 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 396.8116 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 462.2972 396.8116 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 82.5907 438.83 Tm (\021\006\t\003\r\006\t\005)Tj 14.136 0 Td (\022\r\213\210\f\001\003\004\003)Tj 10.539 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_2 1 Tf 9.722 0.6 Td (\t)Tj /T1_1 1 Tf -53.953 -2.033 Td (\025\024\n\023\035\026\036\027\021\027\024\f\021\034)Tj 16.886 0 Td (\215\030\024\001\035\017 3 \022\031\030\f\026 \b/\021)Tj 15.264 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(88%\))Tj 12.047 0 Td (57)Tj /Span<>> BDC ( )Tj EMC (\(89%\))Tj 9.423 0 Td (1,0)Tj -37.1 -1.433 Td (\215\030\024\001\035\017 1\2262)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\026 \216\221)Tj 16.13 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 12.047 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj -26.079 -1.433 Td (\210\021\022\026 \024\021 \216\221)Tj 14.032 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 12.047 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.6646 56.0378 Tm (119)Tj ET endstream endobj 847 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.016 Tc 0.295 Tw 10 0 0 10 70.8661 724.8299 Tm (\200 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n \017\f\f\ \035\036\007\024\r\026\027\017\017 RAPIDO \023\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.224 Tw 0 -1.218 TD (\022\026\026\027\024 \023\030\036\017\n\031\013\036\f\021\r\024 \221\203\ \221, \r\022\035\033\004\026\033\013\036\005 \023\030\024\r\036\007\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.05 Tw T* [(\027\017\036 \022\024\030\024\021\022\024\020\024 \022\031\030\f\026 \022\ \030\031\023\027\024-\235\030\026\022\006\017\024\027\027\024\005 \035\031\ \004\036\r\024\005)16( )]TJ 0.206 Tw T* [(\021\036\030\026\023\017\017 \222\210\212 )0.5(25 \206\030 \f)]TJ /Span<>> BDC ( )Tj EMC 9.855 0 Td (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ \021\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.207 Tw -9.855 -1.218 Td (\030\026\023\017\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\n \022\031\030\f\ \024\n)16( )]TJ 0.148 Tw T* (\216\214\221 \222\210\212 50,4 \206\030. \232\026\f\021\024\021\026 \023\ \024\035\027\t\b \023\026\021\024\n\024\030\235\024\035\024\020\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.184 Tw 0 -1.218 TD (\004\036\f\022\017\b \024\021\r\036\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221 \f\024\f\021\026\r\017\035\026 28%\ , \021\024\020)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.297 Tw 0 -1.218 TD (\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\035\024\027\020\017\030\024\r\026\027\ \027\024\005 \216\214\221)Tj /Span<>> BDC ( )Tj EMC [(\227 14%)16( )]TJ 0 Tc 0 Tw T* (\()Tj /T1_1 1 Tf 0.386 0 Td (p)Tj /T1_0 1 Tf 0.016 Tc /Span<>> BDC 0.494 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\))Tj /Span<>> BDC ( )Tj EMC ([4].)Tj 0 Tc 0.301 Tw -0.88 -1.218 Td (\221\024\021\026\035\034\027\026\016 \027\036\024\026\007\255\033\r\026\027\ \021\027\026\016 \021\036\030\026\023\017\016 \017\n\036\036\021 \023\030\ \036\r\024\f)Tj 0 Tw (-)Tj 0.04 Tw T* (\b\024\007\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC 4.249 0 Td [(\f\030\026\r\027\036\027\017\017 )0.5(\f\024 \f\021\026\027\007\026\030\021\027\t\n )0.5(\030\036\032\017\n\024\n \023\030\036\007)]TJ 0 Tw (-)Tj 0.284 Tw -4.249 -1.218 Td (\024\023\036\030\026\006\017\024\027\027\024\005 \216\214\221, \024\007\027\ \026\022\024 \024\f\021\026\036\021\f\016 \024\021\022\030\t\021\t\n \r\024\ )Tj 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\023\030\024\f \r\t\002\024\030\026 \030\036\032\017\n\026 \035\031\004\036\ \r\024\005 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \221\203\221. )Tj 0.25 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\f\022\036 \035\017\021\036\030\026\021\031\030\t \027\036 \027\ \026\005\007\036\027\024 \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.065 Tw 0 -1.218 TD (\022\024\021\024\030\t\036 \f\030\026\r\027\017\r\026\033\021 \030\036\031\ \035\034\021\026\021\t \035\036\004\036\027\017\016 \n\036\f\021\027\024\ \030\026\f)Tj /Span<>> BDC (-)Tj EMC 0.141 Tw T* (\023\030\024\f\021\030\026\027\036\027\027\024\020\024 \030\026\022\026 \ \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\026\b \221\203\221 )Tj -0.009 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \022\024\030\024\021\022\024\020\ \024 \022\031\030\f\026 \214\221 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027)Tj 0 Tw (-)Tj -0.019 Tw T* (\027\024\020\024 \022\031\030\f\026 \216\214\221, \r)Tj /Span<>> BDC ( )Tj EMC [(\f\r\016\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\004\036\n \027\026\n\017 \002\t\035\024 \017\027\017\006\017\017\030\024\ \r\026)Tj 0 Tw (-)Tj T* (\027\024 \007\026\027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 469.0918 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.03 Tw 10 0 0 10 70.8661 444.7358 Tm [(\222 \f\036\027\021\016\002\030\016 )0.5(2022 \023\024)]TJ /Span<>> BDC ( )Tj EMC 8.265 0 Td [(\235\036\r\030\026\035\034 )0.5(2025 \020\020. )0.5(\023\030\024\r\036\007\036\027\024 )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.905 Tw -8.265 -1.218 Td (\f\023\036\022\021\017\r\027\024\036, \024\007\027\024\006\036\027\021\030\ \024\r\024\036, \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\ \036 )Tj 0.414 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\036 \r\022\035\033\004\036\027\024 125 \004\036\ \035\024\r\036\022. )Tj -0.023 Tw T* [(\230\f\f\035\036\007\024\r\026\027\017\036 )0.5(\007\r\031\b\020\030\031\023\023\024\r\024\036, \030\026\027\007\024\n\017\ \026\006\017\016 )0.5(1:1 \023\030\024)]TJ 0 Tw (-)Tj 0.344 Tw T* (\017\r\024\007\017\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \030\026\027\007\024\n\026\005\036\030\026 \007\035\ \016 \004\017\f\036\035 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\b r)-32.9(and)-16(omus.r)-21.9(u.)]TJ /T1_1 1 Tf T* (\206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\025\ \023\031\021:)Tj /T1_0 1 Tf 0.054 Tw T* (\200 \020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \023\030\024\r\024\007\017\035\f\016 \ \022\024\030\024\021\022\017\005 \022\031\030\f \035\031)Tj 0 Tw (-)Tj 0.089 Tw T* (\004\036\r\024\005 \021\036\030\026\023\017\017 \(\214\221\) \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n\016 \022\031\030\f\026\n\017 \022\024\027\f\024\035\017\007\ \017\030\031\033)Tj 0 Tw (-)Tj -0.044 Tw T* [(\013\036\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 9.128 0 Td [(\f\b\036\n\036 )0.5(XEL)35(O)17(X )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\024\005 )0.6(\220\235\235\036\022\021\026 )]TJ 0 Tw -9.128 -1.218 Td (\004\036\030\036 10\22618)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\016 \214\221.)Tj 0.137 Tw T* (\200 \020\030\031\023\023\036 \207 \023\030\024\r\024\007\017\035\f\016 \ \023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \022\031\030\ \f \b\017)Tj 0 Tw (-)Tj 0.03 Tw T* (\n\017\024\035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \(\216\ \214\221\) \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n\016 \022\031\030\f\026\n\017 \022\024\027\f\024\035\017)Tj 0 Tw (-)Tj 0.139 Tw T* (\007\017\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\ \017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\b\036\n\036 XEL)35(O)17(X \f)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 )Tj 0 Tw T* (\220\235\235\036\022\021\026 \004\036\030\036 10\22618)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\016 \216\214\221.)Tj 0.436 Tw T* (\215\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\005 \024\021\ \r\036\021 \(cCR\) \031\f\021\026\027\026\r\035\017\r\026\035\f\016 )Tj 0.107 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \007\026\027\027\t\b \023\026\035\034\006\ \036\r\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016, \022\024)Tj 0 Tw (-)Tj 0.008 Tw T* [(\035\024\027\024\f\022\024\023\017\017, )0.5(\204\217\221 \024\030\020\026\027\024\r )0.5(\n\026\035\024\020\024 \021\026\026 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.641 0 Td (\024\021\f\031\021\f\021\r\017\017 )Tj 0.46 Tw -17.641 -1.218 Td [(\n\026\022\030\024\f\022\024\023\017\004\036\f\022\017\b )0.5(\023\030\017\027\026\022\024\r \024\023\031\b\024\035\017 )0.5(\004\036\030\036 10\226)]TJ 0.213 Tw T* (18)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\036 \035\031\004\036\r\024\005/\b\017\n\017\024\035\031\004\036\r\024\ \005 )Tj 0.066 Tw T* (\021\036\030\026\023\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \022\024\027\f\021\026\021\026\006\017\017 \023\024\ \035\027\024\020\024 \022\035\017\027\017\004\036\f\022\024)Tj 0 Tw (-)Tj 0.089 Tw T* (\020\024 \024\021\r\036\021\026 \024\023\031\b\024\035\017, \023\026\006\ \017\036\027\021\026\n \023\030\036\007\035\026\020\026\035\024\f\034 \007\ \017\027\026\n\017)Tj 0 Tw (-)Tj 0.071 Tw T* [(\004\036\f\022\024\036 \027\026\002\035\033\007\036\027\017\036, )0.5(\f\024\020\035\026\f\027\024 \f\021\030\026\021\036\020\017\017 )0.5(\027\026\002\035\033\007\036\027\017\016 )]TJ 0.039 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\032\017\007\026\027\017\016 \(\253w)-12(a)15(tch and w)-12(ai)-24(t\273\). \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \023\024\035)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\024\020\024 \022\035\017\027\017\004\036\f\022\024\020\024 \030\036\ \020\030\036\f\f\026 \024\023\031\b\024\035\017, \023\026\006\017\036\027\ \021\026\n \023\030\024)Tj 0 Tw (-)Tj T* (\r\024\007\017\035\024\f\034 \b\017\030\031\030\020\017\004\036\f\022\024\ \036 \035\036\004\036\027\017\036.)Tj 0.17 Tw T* [(\215\024\035\027\t\005 \023\026\021\024\n\024\030\235\024\035\024\020\017\ \004\036\f\022\017\005 )0.5(\024\021\r\036\021 \(pCR\) \031\f\021\026\027\026\r)]TJ 0 Tw (-)Tj 0.008 Tw T* (\035\017\r\026\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \n\024\030\235\024\035\024\020\017\004\036\ \f\022\024\020\024 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.113 Tw T* (\027\017\016 \024\023\036\030\026\006\017\024\027\027\024\020\024 \n\026\ \021\036\030\017\026\035\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \030\036\020\030\036\f\f\036 )Tj 0.101 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\016 \n\036\021\026\f\021\026\021\017\004\036\ \f\022\017 \017\n\036)Tj 0 Tw (-)Tj T* (\027\036\027\027\t\b \035\017\n\235\024\031\035\024\r.)Tj -0.021 Tw 23.244 64.543 Td [(\206\017\023\024\021\036\026 \017\f\f\035\036\007\024\r\026\027\017\016\ : )0.5(\022\024\n\002\017\027\026\006\017\016 \022\024\030\024\021\022\024\020\024\ )0.5(\022\031\030\f\026 )]TJ 0.059 Tw 0 -1.218 TD [(\035\031\004\036\r\024\005 )0.6(\021\036\030\026\023\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.009 0 Td [(\022\031\030\f\024\n )0.5(\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 )0.6(\b\017\n\017\024)]TJ 0 Tw (-)Tj 0.17 Tw -8.009 -1.218 Td (\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\n \030\036\032\017\n\036\ \027\036 \b\031\032\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.019 Tw 0 -1.218 TD (\f\021\024\021\036 \023\024\035\027\t\b \024\021\r\036\021\024\r \024\023\ \031\b\024\035\017 \023\030\016\n\024\005 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj 0.344 Tw 0 -1.218 TD (\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\n \022\031\030\f\ \024\n \b\017\n\017\024\035\031\004\036\r\024\005 )Tj 0 Tw 0 -1.218 TD (\021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\024\n \022\024\027\f\024\035\017\007\017\030\031\033\013\036\ \005 \b\017\n\017\024\021\036\030\026\023\017\017.)Tj /T1_1 1 Tf 0 -1.218 TD (\202\032\022\023\027\032\022\022 \021\n\f\005\007\027\025\022\t:)Tj /T1_0 1 Tf 0 -1.218 TD (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\202\007\036\027\024\022\026\030\006\017\027\024\n\026 \023\030\016\n\024\ \005 \022\017\001\022\017 cT3-T4\026N0-2M0;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td [(\210\006\036\027\022\026 \024\002\013\036\020\024 \f\024\f\021\024\016\027\ \017\016 \002\024\035\034\027\024\020\024 EC)13.2(OG 0-2;)]TJ 0.012 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-255( )]TJ EMC 1 0 Td [(\215\024\007\023\017\f\026\027\027\024\036 )0.6(\007\024\002\030\024\r\024\035\034\027\024\036 )0.5(\017\027\235\024\030\n\017\030\024\r\026\027\027\024\036 )0.6(\f\024)]TJ 0 Tw (-)Tj T* (\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj /T1_1 1 Tf -1 -1.218 Td (\202\032\022\023\027\032\022\022 \025\027\021\n\f\005\007\027\025\022\t:\ )Tj /T1_0 1 Tf T* (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\200\024\030\026\f\021 \n\036\027\036\036 18 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 80 \035\036\021;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\217\036\006\017\007\017\r \030\026\022\026 \023\030\016\n\024\005 \022\017\ \001\022\017;)Tj 1.761 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )1494( )]TJ EMC 1 0 Td (\215\036\030\r\017\004\027\024-\n\027\024\032\036\f\021\r\036\027\027\t\036\ \024\023\031\b\024\035\017 \007\030\031\020\017\b )Tj 0 Tw T* (\035\024\022\026\035\017\026\006\017\005;)Tj -0.029 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-296( )]TJ EMC 1 0 Td (\215\030\036\007\001\036\f\021\r\031\033\013\026\016 \035\031\004\036\r\026\ \016 \021\036\030\026\023\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\t \n\026\035\024)Tj 0 Tw (-)Tj T* (\020\024 \021\026\026;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\207\036\030\036\n\036\027\027\024\f\021\034, \022\024\030\n\035\036\027\ \017\036 \020\030\031\007\034\033;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\203\026\035\017\004\017\036 \024\021\007\026\035\036\027\027\t\b \n\036\ \021\026\f\021\026\024\r;)Tj 0.694 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )427( )]TJ EMC 1 0 Td (\203\026\035\017\004\017\036 \b\030\024\027\017\004\036\f\022\017\b \026\ \002\024\035\036\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 )Tj 0 Tw T* (\007\036\022\024\n\023\036\027\f\026\006\017\017;)Tj -0.044 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-311( )]TJ EMC 1 0 Td [(\210\f\035\024\032\027\036\027\027\t\005 )0.6(\b\026\030\026\022\021\036\030 )0.5(\024\023\031\b\024\035\017 )0.5(\(\023\026\030\026\021\031\n\024\030\026\035\034\027\t\005 )]TJ 0 Tw T* (\026\002\f\006\036\f\f, \026\027\036\n\017\016 Hb)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (100 \020/\035\).)Tj /T1_1 1 Tf -1 -1.218 Td (\202\032\022\023\027\032\022\022 \022\024\n\f\005\007\027\025\022\t:)Tj /T1_0 1 Tf T* (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\210\021\022\026 \023\026\006\017\036\027\021\026 \024\021 \031\004\026\ \f\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017)Tj 0.088 Tw -1 -1.218 Td (\215\036\030\r\017\004\027\026\016 \021\024\004\022\026: \004\026\f\021\024\ \021\026 \023\024\035\027\t\b \024\021\r\036\021\024\r \(\022\035\017\027\ \017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b\)\ .)Tj T* (\200\021\024\030\017\004\027\t\036 \021\024\004\022\017:)Tj 0.055 Tw T* (\251)Tj /Span<>> BDC [( )-212( )]TJ EMC 1 0 Td (\022\024\n\023\035\026\036\027\021\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\005 \021\036\030\026\023\ \017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tw (-)Tj 0.094 Tw T* (\n\036\027\036\027\017\036\n \022\024\030\024\021\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\024 \022\031\ \030\f\024\r )Tj 0 Tw T* (\214\221;)Tj 0.131 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-136( )]TJ EMC 1 0 Td (\004\026\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\026 \017\027\021\030\026- \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Cl)-15.8(av)-15.9(ien\226Dind)-16(o [5];)]TJ 0.045 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-222( )]TJ EMC 1 0 Td [(\004\026\f\021\024\021\026 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(3\2264)]TJ /Span<>> BDC ( )Tj EMC 10.576 0 Td [(\f\021\036\023\036\027\017 )0.6(\035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 )]TJ 0.094 Tw -10.576 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 )0.5(R)-12(T)20(OG )0.5([6] \017)]TJ /Span<>> BDC ( )Tj EMC 9.001 0 Td [(\b\017\n\017\024\021\036\030\026\023\017\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 7.554 0 Td [(\001\022\026\035\036 )0.5(\021\024\022)]TJ 0 Tw (-)Tj -16.555 -1.218 Td [(\f\017\004\027\024\f\021\017 NCI-CT)35.1(C)20(AE [7];)]TJ -0.233 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\022\026\004\036\f\021\r\024 )-233(\n\036\024\030\036\022\021\031\n\220\022\021\024\n\017\017;)]TJ T* (\251)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\004\026\f\021\024\021\026 )-233(R0-\030\036\036\022\006\017\005.)]TJ 0.044 Tw T* (\215\030\017 \n\024\013\027\024\f\021\017 \017\f\f\035\036\007\024\r\026\ \027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 80%, \007\024\r\036\030\017\021\036\035\034\027\024\n )Tj 0.062 Tw T* (\017\027\021\036\030\r\026\035\036)Tj /Span<>> BDC ( )Tj EMC (\227 95%, \024\032\017\007\026\036\n\024\005 \r\036\035\017\004\017\027\036\ \220\235\235\036\022\021\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.019 Tw T* (\n\036\027\036\036 10% \(\023\030\017\n\036\027\036\027\017\036 \022\024\ \030\024\021\022\024\020\024 \022\031\030\f\026 \214\221 \027\036 \b\031\ \032\036, )Tj 0.354 Tw T* (\004\036\n \023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005\ \216\214\221 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\030\024\r\036\007\036\027\017\016 )Tj 0.119 Tw T* (\221\203\221\), \017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\036\n\024\005 \004\026\f\021\024\021\036 \023\024\035\ \027\t\b \024\021\r\036\021\024\r \024\023\031\b\024\035\017 )Tj 0.291 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(20\22630%, )0.5(\030\026\n\036\030 \r\t\002\024\030\022\017, )0.5(\f\024\020\035\026\f\027\024 )0.5(\020\017\023\024\021\036\036 \027\036 )]TJ 0.043 Tw T* [(\n\036\027\034\001\036\005 \220\235\235\036\022\021\017\r\027\024\f\021\017\ \(\253non-infer)-36.9(ior)-37(i)-23.9(t)-10(y tr)-36.9(ial\273\), \f\024)]TJ 0 Tw (-)Tj 0.112 Tw T* (\f\021\026\r\035\016\036\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (250 \023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.248 Tw T* (\024\021\r\036\021\f\021\r\017\036\n \r\036\035\017\004\017\027\t \220\235\ \235\036\022\021\026 \024\032\017\007\026\036\n\024\005 \(\n\036\027\036\ \036 )Tj -0.034 Tw T* (10%\) \023\024)Tj /Span<>> BDC ( )Tj EMC 3.527 0 Td [(\023\036\030\r\017\004\027\024\005 )0.5(\021\024\004\022\036 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.856 0 Td [(\023\030\024\n\036\032\031\021\024\004\027\024\n )0.5(\026\031\007\017\021\036, )]TJ 0.178 Tw -12.383 -1.218 Td (\002\t\035\024 \023\030\017\027\016\021\024 \030\036\001\036\027\017\036\ \026\022\024\027\004\017\021\034 \027\026\002\024\030 \023\026\006\017\ \036\027\021\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\027\024\r\017\021\034 \017\f\f\035\036\007\024\r\026\027\017\ \036 \007\024\f\030\024\004\027\024.)Tj 0.554 Tw T* (\215\030\024\021\024\022\024\035 \030\026\027\007\024\n\017\017\030\024\ \r\026\027\027\024\020\024 \022\035\017\027\017\004\036\f\022\024\020\024\ \017\f)Tj 0 Tw (-)Tj 0.474 Tw T* (\f\035\036\007\024\r\026\027\017\016 \030\026\f\f\n\024\021\030\036\027 \ \017)Tj /Span<>> BDC ( )Tj EMC (\031\021\r\036\030\032\007\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\f\036\007\026)Tj 0 Tw (-)Tj 0.261 Tw T* (\027\017\017 \035\024\022\026\035\034\027\024\020\024 \220\021\017\004\036\ \f\022\024\020\024 \022\024\n\017\021\036\021\026 \205\206\207\211 \253\203\ \204\230\037 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 19.9527 56.0378 Tm (118)Tj ET endstream endobj 846 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-10(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ \026)11(\004\005\017\224\n\n \b\022\020\004\225\004\t\n\n \005\017\r\017 )]TJ 0 -1 TD [(\224\005\213\024\025\221 \r\n\204\r\n: \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 42.014 1 Td [(Ef)-31(f)-21(icacy of\022total neoadju)10(v)10(ant th)11(er)21.1(apy for r)31(ectal )]TJ 4.252 -1 Td [(cancer: r)31.1(esults of\022a\022r)21(andomiz)10(ed trial)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 440.8534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 440.8534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 413.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 413.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 359.1763 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.014 Tw 9 0 0 9 90.7087 730.4919 Tm [(AIM: )0.6(to )0.6(com)16(pare )0.6(the )0.6(treatment )0.6(outcomes )0.6(of )0.5(rectal )0.7(cancer )0.6(patients )0.6(using )0.6(tw)12(o )0.6(regimens )0.6(of )0.6(to)13(tal )0.6(neoadjuv)16(ant )0.6(therap)12(y )]TJ 0.158 Tw 0 -1.111 TD [(\(TNT\): )0.6(shor)-40(t-course )0.7(radio)13(therap)12(y )0.6(with )0.5(three )0.6(cycles )0.6(of )0.5(consolid)26.1(ating )0.6(chemo)13(therap)12(y )0.5(and )0.5(long-course )0.6(chemoradio)]TJ 0 Tw (-)Tj 0.023 Tw T* [(therap)12(y with three cycles of consolid)26.1(ating chemo)13(therap)12.1(y)32(.)]TJ 0.056 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a p)46(rospectiv)13(e, Sing)13(le-Center)61.1(, R)20(andomized S)28(tudy)32.1(. F)27(rom Sep)13(tember 2022 to F)11(ebruar)-43(y 2025, )]TJ 0.119 Tw T* [(125 patients w)12(ere enrolled in the study)32(. Of these, 64 w)12(ere assigned to Group A and 61 to Group B. In Group A)12(, )]TJ 0.026 Tw 0 -1.111 TD [(patients receiv)13.1(ed a shor)-39.9(t-course radio)13(therap)12(y \(RT\) regimen follow)12.1(ed by three cycles of consolid)26(ating chemo)13(therap)12(y )]TJ 0.093 Tw 0 -1.111 TD [(with )0.5(the )0.5(XELO)20(X )0.5(regimen. )0.5(T)56(reatment )0.6(response )0.5(w)13(as )0.5(assessed )0.5(10\23118)]TJ /Span<>> BDC ( )Tj EMC [(w)12(eek)-22.9(s af)-45.9(ter )0.5(the )0.5(com)16(pletion )0.5(of )0.5(radio)13(therap)12(y)32(. )0.5(In )]TJ 0.061 Tw T* [(Group B, patients receiv)13(ed a long-course chemoradio)13.1(therap)12(y \(CRT\) regimen follow)12(ed by three cycles of consolid)26(at)]TJ 0 Tw (-)Tj 0.125 Tw T* [(ing chemo)13(therap)12.1(y with the XELO)20.1(X regimen. T)56(reatment response w)13(as assessed 10\23118)]TJ /Span<>> BDC ( )Tj EMC [(w)12(eek)-23(s af)-46(ter the com)16(pletion )]TJ 0.138 Tw T* [(of )0.5(chemoradio)13.1(therap)12(y)32(. )0.5(The )0.5(p)46(r)-37(imar)-43(y )0.5(endpoint )0.5(of )0.5(the )0.5(study )0.5(is the )0.5(rate )0.5(of )0.5(com)16(plete tumor response \(pathological )]TJ 0.023 Tw T* [(com)16(plete response, pCR\).)]TJ 0.061 Tw T* [(RESUL)30(T)-10(S: the median tumor size w)13(as 50 mm \(interq)14.1(uar)-40(tile rang)12(e, IQR: 24\231123 mm\) in Group A and 47 mm \(IQR: )]TJ -0.03 Tw T* (27\23176 mm\) in Group B \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.3\). There w)12(ere no signif)-42.9(icant dif)-40(ferences in the p)46(resence or absence of in)11(v)13(olv)13(ed circular )]TJ -0.034 Tw T* [(resection )0.6(margin )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 7.786 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.698 0 Td [(0.9\) )0.5(or )0.6(e)-15(xtramural )0.5(v)16(ascular )0.6(in)11(v)16(asion )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 15.282 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.698 0 Td [(0.8\) )0.5(before )0.5(treatment )0.5(initiation. )0.6(Bo)13(th )0.5(g)14(roups )0.6(show)12(ed )]TJ 0.047 Tw -24.465 -1.111 Td [(com)16(parable results in ter)-14(ms of com)16(pliance \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.0\), tolerability \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.7\), and to)14(xicity \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\) of radio)13(therap)12(y)32(. )]TJ 0.068 Tw T* [(N)17(o statistically signif)-42.9(icant dif)-39.9(ferences w)12(ere found in the com)16(pliance \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.0\), tolerability \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\), and to)14(xicity )]TJ -0.03 Tw T* (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.2\) of chemo)13(therap)12.1(y)32(. Surgical outcomes w)12(ere also com)16.1(parable reg)12(arding the rate of neg)12(ativ)12.9(e resection margins )]TJ -0.033 Tw T* (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.0\), q)14(uality of mesorectal e)-15(xcision \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.5\), deg)14(ree of tumor response to neoadjuv)16(ant treatment \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.6\), and )Tj 0.071 Tw T* [(postoperativ)13.1(e com)16(plications \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\). The rate of com)16.1(plete tumor responses \(bo)13(th clinical and pathological\) did )]TJ -0.001 Tw T* [(no)13(t )0.6(dif)-40(fer )0.6(signif)-43(icantly )0.6(betw)12.1(een )0.5(the )0.6(g)13.9(roups. )0.7(With )0.5(a )0.6(follow-up )0.6(ranging )0.6(from )0.6(3 )0.5(to )0.6(35 )0.5(months )0.5(\(median )0.5(18 )0.6(months\), )0.6(the )]TJ 0.022 Tw T* [(clinical com)16.1(plete response rate w)13(as 5/61)]TJ /Span<>> BDC ( )Tj EMC (\(8.2%\) in Group A and 11/64 \(17.2%\) in Group B \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.18\). The)Tj /Span<>> BDC ( )Tj EMC (patho)Tj 0 Tw (-)Tj 0.11 Tw T* [(logical com)16(plete response rate w)13(as 9/53 \(14.7%\) vs. 6/51)]TJ /Span<>> BDC ( )Tj EMC [(\(9.3%\), respectiv)13(ely \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.6\). The ov)13(erall com)16(plete )]TJ -0.019 Tw T* [(response rate w)13(as 14/61)]TJ /Span<>> BDC ( )Tj EMC [(\(22.9%\) in the shor)-40(t-course RT and 17/64 \(26.5%\) in the long-course CRT g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.6\).)Tj 0.03 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: the com)16(pared TNT regimens are com)16.1(parable in com)16(pliance, tolerability)42(, and to)14(xicity)32(. The combination )]TJ 0.127 Tw 0 -1.111 TD [(of SCRT with consolid)26(ation chemo)13(therap)12.1(y in a neoadjuv)16(ant regimen is com)16(parable in the freq)14(uency of com)16(plete )]TJ 0.023 Tw T* [(responses com)16(pared with a CRT with consolid)26(ation chemo)13(therap)12(y)32.1(.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 465.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( to)13(tal neoadjuv)16.1(ant therap)12.1(y)14(; rectal cancer; TNT)82(; locally adv)16.1(anced rectal cancer)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.076 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.5(C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.085 Tw 6.52 0 Td [( )0.5(F)-6.5(a)-14.9(y)-34(z)-12.1(u)-8.4(l)-16.7(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC 4.289 0 Td [(R)-21.4(.)-9.8(I)-10.3(.)-23.5(, )0.5(A)-11.7(l)-23.6(e)-16.2(k)-39.6(s)-22.9(e)-25.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 6.372 0 Td [(M)-7.1(.)40.6(V)39.7(.)-23.5(, )0.5(R)-30.3(y)-19.6(b)-17.7(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.271 0 Td [(E)-5.6(.)15(G)-11.6(.)-23.5(, )0.5(B)-16.4(a)-11.4(l)-33(k)-24.3(a)-10.1(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.362 0 Td [(A)-23(.)-23.9(A)-23(. )0.5(Ef)-62.5(f)-63(i)-5(c)-21.5(a)-11.1(c)-42.4(y )0.5(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC 7.321 0 Td [(t)-21.9(o)-15.8(t)-36.8(a)-11.4(l )0.5(n)-16.1(e)-21(o)-18.2(a)-13(d)-16.3(j)-3.5(u)-14.9(v)-28.4(a)-7.6(n)-17.3(t )0.5(t)-26.1(h)-15.1(e)-12.1(r)-30.8(a)-8.7(p)-19.7(y )0.5(f)-25.1(o)-11.8(r )0.5(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l )0.5(c)-21.5(a)-7.6(n)-10(c)-9.7(e)-12.1(r)-24.7(:)23( )]TJ 0.011 Tc -0.035 Tw -37.14 -1.2 Td [(r)-19.1(e)-22.8(s)-8.8(u)-8.4(l)-15.3(t)-48.9(s o)-12(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(r)-30.8(a)-7.6(n)-14.5(d)-11.1(o)-9.2(m)-14.5(i)-8.3(z)-13.9(e)-21(d t)-30.7(r)-56.4(i)-5.1(a)-11.4(l)-31.7(. )]TJ /T1_1 1 Tf 0.021 Tc -0.021 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.7(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.011 Tc -0.035 Tw 19.177 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)29.8(1)12.6(6)-25.9(\226)50.8(12)8.8(4)-0.9(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.4(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.8(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.2(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.1(1)26.9(-)55.2(1)29.8(1)12.6(6)-26.7(-)55.1(12)8.8(4)]TJ /T1_2 1 Tf 0.01 Tc 0.07 Tw -19.172 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.075 Tw 10.681 0 Td ( \214\020\235\016\r\f\022\025 \206.\002., \214\216\221\210 \253\001\215\002\ \037 \n\031\f\031\033\032\031\n\023\031\f\031\b\022\022 \022\026\027\025\ \022 \003.\001.)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 \003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.686 -1.2 Td (\024\023\032.)Tj /Span<>> BDC ( )Tj EMC (28, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: faiz\ ulin_ri@gnck.ru)Tj /T1_2 1 Tf 0.01 Tc 0.024 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.5(F)12.9(OR)4.9( )0.6(C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.029 Tw 14.062 0 Td [( )0.5(F)15(ayzulin )0.6(R.I., )0.5(Ryzhikh )0.6(N)18(ational )0.6(Medical )0.6(R)20.9(esearch )0.5(Center )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 23.353 0 Td [(Colop)46(roctology )0.6(Salyama )0.5(Adilya )0.6(st., )0.5(2/28, )0.5(Moscow)52.1(, )]TJ 0.023 Tw -37.42 -1.2 Td [(123423, R)22(ussia; e-mail: faizulin_r)-37(i@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 17.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 17.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 298.5999 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.255 Tw 10 0 0 10 42.5197 274.2439 Tm (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\021\026\027\007\ \026\030\021\024\n \035\036\004\036\027\017\016 \n\036\f\021\027\024\030\ \026)Tj 0 Tw (-)Tj 0.154 Tw 0 -1.218 TD (\f\023\030\024\f\021\030\026\027\036\027\027\024\020\024 \030\026\022\026\ \023\030\016\n\024\005 \022\017\001\022\017 \016\r\035\016\036\021\f\016\ \023\030\024)Tj 0 Tw (-)Tj 0.604 Tw T* (\r\036\007\036\027\017\036 \027\036\024\026\007\255\033\r\026\027\021\027\ \024\005 \b\017\n\017\024\035\031\004\036\r\024\005 \021\036\030\026\023\ \017\017 )Tj 0.365 Tw T* (\(\216\214\221\), \022\024\021\024\030\026\016 \023\024\r\024\035\016\036\ \021 \031\n\036\027\034\001\017\021\034 \030\026\n\036\030 \023\036\030\ )Tj 0 Tw (-)Tj 0.327 Tw T* (\r\017\004\027\024\005 \024\023\031\b\024\035\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\027\017\032\026\036\021 \030\017\f\022 \030\036\006\ \017\007\017\r\026 )Tj 0 Tw T* (\026\002\024\035\036\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([1].)Tj 0.501 Tw T* (\203\024\r\t\n \220\021\026\023\024\n \030\026\r\017\021\017\016 \027\036\ \024\026\007\255\033\r\026\021\027\024\005 \021\036\030\026\023\017\017 \ )Tj 0.562 Tw T* [(\f\021\026\035\026 \021\024\021\026\035\034\027\026\016 \027\036\024\026\ \007\255\033\r\026\027\021\027\026\016 )0.5(\021\036\030\026\023\017\016 \(\221\203\221\), )]TJ 0.321 Tw T* (\r\022\035\033\004\026\033\013\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \023\030\024\r\036\007\036\027\017\036 \022\026\022 \035\031\ \004\036\r\024\005, \021\026\022 )Tj 0.041 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\n \030\036\032\017\n\036\ . \200\026\032\027\t\n )Tj 0.357 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\024\n \221\203\221 \016\r\035\016\ \036\021\f\016 \031\r\036\035\017\004\036\027\017\036 \004\026\f\021\024\ \021\t )Tj 0.349 Tw T* (\023\024\035\027\t\b \024\021\r\036\021\024\r \024\023\031\b\024\035\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\021\027\024\036 \035\036\004\036)Tj 0 Tw (-)Tj 0.406 Tw T* [(\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\017 )0.5(\f\024 \f\021\026\027\007\026\030\021\027\t\n )0.5(\030\036\032\017\n\024\n )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.193 Tw T* [(\035\024\027\020\017\030\024\r\026\027\027\024\005 )0.6(\b\017\n\017\024\035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017. )0.6(\221\026\022, )0.5(K)-16(asi)]TJ /Span<>> BDC ( )Tj EMC 21.26 0 Td (A. )Tj 0.207 Tw -21.26 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2020 \020. \023\030\024\r\036\035\017 \n\036\021\026\026\027\026\035\017\  \022\026\022 \030\026\027\007\024)Tj 0 Tw (-)Tj 0.232 Tw T* (\n\017\017\030\024\r\026\027\027\t\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036)]TJ 0 Tw (-)Tj 0.28 Tw T* [(\007\024\r\026\027\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n \023\024\022\026\026\035\017, )0.5(\004\021\024 \004\026\f\021\024\021\026 )0.5(\023\024\035\027\t\b )]TJ 0.074 Tw 23.244 21.92 Td (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021\r\036\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\036 \221\203\221 \f\021\026\021\017\f)Tj 0 Tw (-)Tj -0.042 Tw T* [(\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024 \r\t\001\036, )0.5(\004\036\n \r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\032\017\n\036 )0.5(\023\030\024\035\024\027\020\017\030\024\r\026\027)]TJ 0 Tw (-)Tj 0.141 Tw T* (\027\024\005 \216\214\221 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\036\021 29,9% \023\030\024\021\017\r 14,9%, \f\ \024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\036\027\027\024 \(\210\231 2,44; 95% \212\230 1,99\2265,98;p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\))Tj /Span<>> BDC ( )Tj EMC ([2].)Tj 0.447 Tw T* [(\200\026\032\027\024 )0.6(\023\024\007\004\036\030\022\027\031\021\034, )0.5(\004\021\024 )0.6(\221\203\221 )0.5(\n\024\032\036\021 )0.5(\023\030\024\r\024\007\017\021\034\f\016 )]TJ 0.086 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \022\026\022 \017\027\007\031\022\ \006\017\024\027\027\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017)Tj 0 Tw (-)Tj 0.327 Tw T* (\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\017. \200\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n \017\f)Tj 0 Tw (-)Tj 0.433 Tw T* [(\f\035\036\007\024\r\026\027\017\017 C)20(A)15(O/ARO/AIO-12 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\ \024, )]TJ 0.3 Tw T* (\004\021\024 \023\030\036\007\023\024\004\021\017\021\036\035\034\027\t\n\ \007\035\016 \r\024\027\017\022\027\024\r\036\027\017\016 \023\024\035\ \027\t\b )Tj -0.036 Tw T* (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021\r\036\021\024\r \024\023\031\b\024\035\017 \016\r\035\016\036\021\f\ \016 \023\030\017)Tj 0 Tw (-)Tj 0.097 Tw T* (\n\036\027\036\027\017\036 \022\024\027\f\024\035\017\007\017\030\031\033\ \013\036\005 \b\017\n\017\024\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj -0.011 Tw T* (\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\024\027\027\024\005. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \004\026\ \f\021\024\021\026 )Tj 0.26 Tw T* (\023\024\035\027\t\b \023\026\021\024\n\024\030\235\024\035\024\020\017\004\ \036\f\022\017\b \024\021\r\036\021\024\r \024\023\031\b\024\035\017 \f\024\ )Tj 0 Tw (-)Tj -0.046 Tw T* (\f\021\026\r\017\035\026 25% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ )Tj /Span<>> BDC (-)Tj EMC 0.115 Tw T* (\021\036\030\026\023\017\036\005 \023\030\024\021\017\r 17% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\024\027\027\024\005 )Tj 0.044 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\036\005 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_3 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) [3]. \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034\ , \004\021\024 )Tj 0.065 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \023\026\006\017\036\027\021\ \026\n \023\030\024\r\024\007\017\035\f\016 \023\030\024\035\024\027\020\ \017\030\024)Tj 0 Tw (-)Tj 0.19 Tw T* [(\r\026\027\027\t\005 )0.5(\022\031\030\f \216\214\221 )0.5(\f\031\n\n\026\030\027\024\005 \024\004\026\020\024\r\024\005 )0.5(\007\024\024\005 )0.5(\(\222\210\212\) )]TJ 0 Tw T* (50,4 \206\030.)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.7145 56.0378 Tm (117)Tj ET endstream endobj 843 0 obj [852 0 R] endobj 844 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 259.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 259.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 221.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 221.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-116-124)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 125.5518 695.3259 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-9.9(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ )]TJ -1.595 -1.105 Td [(\026)11(\004\005\017\224\n\n \b\022)-23.2(\020\004\225\004\t\n\n \005\017\r\017 \224\005\213\024\025\221 \r\n\204\r\ \n: \005\004\212)21.1(\002\020\200)21(\026)11(\017\026\217 )]TJ 3.159 -1.105 Td [(\005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\210\017\221\212)21(\002\020\n\t\022)-23.2(\033)124(.\030.)]TJ 8.162 0 0 8.162 155.8351 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 160.4711 628.822 Tm [(, \f)-21(\020\004\r\016\004\004\b\022)-23.2(\235.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 253.0316 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 264.3522 628.822 Tm [(, \033\217\255\017\r)10(\025\b\022)-23.2(\240.\031)72(.)]TJ 0 Tw 8.162 0 0 8.162 344.3835 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 349.0195 628.822 Tm [(, \006\017\020\r\017\005\025\b\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 442.966 633.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 614.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 611.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n\022)-23.3(\f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \016)-10(\026\005)-31(.\022)-23.3(2)35(8, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 587.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf -0.022 Tw 9 0 0 9 119.0551 568.6488 Tm (\037\036\035\034: \024\032\020\021\025\022\023\017 \032\027\016\r\f\017\023\ \020\023\013 \f\027\007\027\025\022\t \240\031\f\017\025\013\200 \032\020\ \n\031\026 \033\032\t\026\031\235 \n\022\213\n\022 \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\022\026\027\025\027\025\022\027\026 \030\021\r\200 \032\027\255\ \022\026\031\021 \023\031\023\020\f\017\025\031\235 )Tj 0.04 Tw 0 -1.111 TD [(\025\027\031\020\030\236\005\021\020\025\023\025\031\235 )0.6(\023\027\032\020\033\022\022 )0.5(\(\001\): )0.5(\n\031\032\031\023\n\031\b\031 )0.5(\n\r\032\024\020 )0.5(\f\r\007\027\021\031\235 )0.5(\023\027\032\020\033\022\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\023\032\027\026\t \n\r\032\024\020\026\022 )0.5(\n\031\025\024\031\f\022\030\022\032\r\005\212\027\235 \200\022)]TJ 0 Tw (-)Tj -0.005 Tw T* (\026\022\031\023\027\032\020\033\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\f\031\025\b\022\032\031\021\020\025\025\031\235 \200\022\026\ \022\031\f\r\007\027\021\031\235 \023\027\032\020\033\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\023\032\027\026\t \n\r\032\024\020\026\022 \n\031\025\024\031\f\022\030\ \022\032\r\005\212\027\235 \200\022\026\022\031\023\027\032\020\033\022\022\ .)Tj 0.004 Tw T* (\004\003\037\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \024)Tj /Span<>> BDC ( )Tj EMC 9.557 0 Td [(\024\027\025\023\t\240\032\t )0.5(2022 \033\031)]TJ /Span<>> BDC ( )Tj EMC [(\203\027\021\032\020\f\017 )0.5(2025 \b\b. )0.5(\033\032\031\021\027\030\027\025\031 \033\032\031\024\033\027\n\023\022\021\ \025\031\027 \031\030\025\031\006\027\025\023\032\031\021\031\027 \032\020\ \025\030\031)]TJ 0 Tw (-)Tj 0.062 Tw -9.557 -1.111 Td (\026\022\016\022\032\031\021\020\025\025\031\027 \022\024\024\f\027\030\031\ \021\020\025\022\027. \211)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\021\031\030\022\f\024\t \n\031\032\031\023\n\022\235 \n\r\032\ \024 \f\r\007\027\021\031\235 \023\027\032\020\033\022\022 \(\035\) \024\ )Tj /Span<>> BDC ( )Tj EMC (\023\032\027\026\t \n\r\032\024\020\026\022 )Tj -0.022 Tw 0 -1.111 TD (\n\031\025\024\031\f\022\030\022\032\r\005\212\027\235 \200\022\026\022\031\ \023\027\032\020\033\022\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\024\200\027\026\027 XELOX \024)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\031\235 \204\203\203\027\n\023\020 \007\027\032\027\016\ 10\23118)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\f\017 \033\031\024\f\027 \031\n\031\025\007\020\025\022\ \t \035. )Tj 0.045 Tw 0 -1.111 TD (\211)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221 \033\032\031\021\031\030\022\f\024\t \033\032\031\ \f\031\025\b\022\032\031\021\020\025\025\013\235 \n\r\032\024 \200\022\026\ \022\031\f\r\007\027\021\031\235 \023\027\032\020\033\022\022 \(\225\035\ \) \024)Tj /Span<>> BDC ( )Tj EMC (\023\032\027\026\t \n\r\032\024\020\026\022 \n\031\025\024\031\f\022\030\ \022\032\r)Tj 0 Tw (-)Tj 0.059 Tw T* (\005\212\027\235 \200\022\026\022\031\023\027\032\020\033\022\022 \033\031\ )Tj /Span<>> BDC ( )Tj EMC (\024\200\027\026\027 XELOX \024)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\031\235 \204\203\203\027\n\023\020 \007\027\032\027\016\ 10\23118)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\f\017 \033\031\024\f\027 \031\n\031\025\007\020\025\022\ \t \225\035. \207\020)Tj /Span<>> BDC ( )Tj EMC (\031\240\031\016)Tj /Span<>> BDC (-)Tj EMC 0.043 Tw T* (\025\020\007\027\025\025\013\235 \033\027\032\022\031\030 \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027 \021\n\f\005\007\027\025\031\ 125 \007\027\f\031\021\027\n, \022\016)Tj /Span<>> BDC ( )Tj EMC (\025\022\200 64 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\022 61)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221. \004\027\032\021\022\007\025\020\t )Tj 0.023 Tw T* (\023\031\007\n\020 \022\024\024\f\027\030\031\021\020\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 \007\020\024\023\031\023\020 \033\031\f\025\013\200 \031\023\021\027\ \023\031\021 \031\033\r\200\031\f\022.)Tj 0.173 Tw T* (\206\036\207\210\035\034\003\201: \026\027\030\022\020\025\020 \032\020\ \016\026\027\032\020 \031\033\r\200\031\f\022 \024\031\024\023\020\021\022\ \f\020 50 \(\022\025\023\027\032\n\021\020\032\023\022\f\017\025\013\235\ \032\020\016\026\020\200 \(IQR\): 24\231123\) \026\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.099 Tw T* (\021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\022 47 \(IQR: 27\23176\) \026\026)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,3\), \025\027 \240\013\f\031 \032\020\016\f\022\007\022\235 \033\031)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\005 \022\f\022 \031\023\024\r\023\024\023\021\022\ \005 )Tj 0.019 Tw T* (\021\031\021\f\027\007\027\025\022\t \006\022\032\n\r\f\t\032\025\031\b\031\ \n\032\020\t \032\027\016\027\n\006\022\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,9\) \022\f\022 \022\025\021\020\016\022\022 \204\n\024\023\032\020\026\ \r\032\020\f\017\025\013\200 \024\031\024\r\030\031\021 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\) \030\031)Tj /Span<>> BDC ( )Tj EMC (\025\020\007\020\f\020 )Tj 0.157 Tw T* (\f\027\007\027\025\022\t. \211)Tj /Span<>> BDC ( )Tj EMC [(\031\240\027\022\200 \b\032\r\033\033\020\200 \033\031\f\r\007\027\025\013\ \024\031\033\031\024\023\020\021\022\026\013\027 )0.5(\032\027\016\r\f\017\023\020\023\013 \033\031)]TJ /Span<>> BDC ( )Tj EMC (\n\031\026\033\f\020\027\025\023\025\031\024\023\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\), \033\027\032\027\025\031\024\022)Tj 0 Tw (-)Tj 0.102 Tw 0 -1.111 TD (\026\031\024\023\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7\) \022)Tj /Span<>> BDC ( )Tj EMC (\023\031\n\024\022\007\025\031\024\023\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\) \f\r\007\027\021\031\235 \023\027\032\020\033\022\022. \020\n\255\ \027 \025\027 \021\013\t\021\f\027\025\031 \024\023\020\023\022\024\023\022\ \007\027\024\n\022 \016\025\020\007\022\026\013\200 )Tj 0.09 Tw 0 -1.111 TD [(\032\020\016\f\022\007\022\235 )0.6(\033\031)]TJ /Span<>> BDC ( )Tj EMC 5.425 0 Td [(\n\031\026\033\f\020\027\025\023\025\031\024\023\022 )0.7(\(\032)]TJ /Span<>> BDC ( )Tj EMC 8.78 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.822 0 Td [(1,0\), )0.6(\033\027\032\027\025\031\024\022\026\031\024\023\022 )0.6(\(\032)]TJ /Span<>> BDC ( )Tj EMC 10.111 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.822 0 Td [(0,8\) )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 2.775 0 Td [(\023\031\n\024\022\007\025\031\024\023\022 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 7.155 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.822 0 Td [(0,2\) )0.5(\200\022\026\022\031\023\027\032\020\033\022\022. )]TJ 0.075 Tw -36.713 -1.111 Td (\205\031\033\031\024\023\020\021\022\026\013 \031\n\020\016\020\f\022\024\ \017 \022)Tj /Span<>> BDC ( )Tj EMC (\032\027\016\r\f\017\023\020\023\013 \200\022\032\r\032\b\022\007\027\024\ \n\031\b\031 \f\027\007\027\025\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (\007\020\024\023\031\023\027 \031\023\032\022\006\020\023\027\f\017\025\013\ \200 \b\032\020\025\022\006 \032\027\016\027\n)Tj 0 Tw (-)Tj -0.014 Tw T* (\006\022\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\), \n\020\007\027\024\023\021\r \026\027\016\031\032\027\n\023\r\026\ \204\n\023\031\026\022\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,5\), \024\023\027\033\027\025\022 \031\023\021\027\023\020 \031\033\r\200\ \031\f\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\020\030\236\005\021\020\025\023\025\031\027 \f\027\007\027\025\ \022\027 )Tj 0.003 Tw T* (\(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\) \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\013\026 \031\024\ \f\031\255\025\027\025\022\t\026 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\). \232\020\024\023\031\023\020 \033\031\f\025\013\200 \031\023\021\027\ \023\031\021 \031\033\r\200\031\f\022 \(\n\020\n \n\f\022\025\022\007\027\ \024\n\022\200, )Tj 0.13 Tw T* (\023\020\n \022)Tj /Span<>> BDC ( )Tj EMC (\033\020\023\031\026\031\032\203\031\f\031\b\022\007\027\024\n\022\200\)\ \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\ \026\031 \025\027 \032\020\016\f\022\007\020\f\020\024\017 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\027\022\200 \b\032\r\033\033\020\200: \007\020\024\023\031\023\020\ \033\031\f\025\013\200 )Tj 0.118 Tw T* (\n\f\022\025\022\007\027\024\n\022\200 \031\023\021\027\023\031\021 \033\ \032\022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\024\f\027\255\027\025\025\031\024\023\022 \031\023 3 \030\031\ )Tj /Span<>> BDC ( )Tj EMC (35 \026\027\024\t\006\027\021 \024)Tj /Span<>> BDC ( )Tj EMC (\026\027\030\022\020\025\031\235 \021)Tj /Span<>> BDC ( )Tj EMC (18 \026\027\024\t\006\027\021 \024\031\024\023\020\021\022\f\020 5/61 )Tj -0.017 Tw T* (\(8,2%\) \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\022 11/64 \(17,2%\))Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\). \232\020\024\023\031\023\020 \033\031\f\025\013\200 \033\020\023\ \031\026\031\032\203\031\f\031\b\022\007\027\024\n\022\200 \031\023\021\027\ \023\031\021 )Tj 0.042 Tw T* (\024\031\024\023\020\021\022\f\020 9/53 \(14,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\031\023\022\021 6/51 \(9,3%\), \024\031\031\023\021\027\023\ \024\023\021\027\025\025\031 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\). \217\240\212\020\t \007\020\024\023\031\023\020 \033\031\f\025\013\ \200 \031\023\021\027)Tj 0 Tw (-)Tj -0.026 Tw 0 -1.111 TD (\023\031\021)Tj /Span<>> BDC ( )Tj EMC (\227 14/61 \(22,9%\) \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \n\031\032\031\023\n\031\b\031 \n\r\032\024\020 \035\  \022)Tj /Span<>> BDC ( )Tj EMC (17/64 \(26,5%\) \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \033\032\031\f\031\025\b\022\032\031\021\020\025\025\ \031\235 \225\035 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\).)Tj 0.139 Tw 0 -1.111 TD (\207\003\202\035\224\232\036\001\002\036: \024\032\020\021\025\022\021\020\ \027\026\013\027 \032\027\255\022\026\013 \001 \024\031\033\031\024\023\ \020\021\022\026\013 \033\031)Tj /Span<>> BDC ( )Tj EMC (\n\031\026\033\f\020\027\025\023\025\031\024\023\022, \033\027\032\027\025\ \031\024\022\026\031\024\023\022 \022)Tj /Span<>> BDC ( )Tj EMC (\023\031\n\024\022\007\025\031)Tj 0 Tw (-)Tj 0.027 Tw T* (\024\023\022. \202\031\026\240\022\025\020\006\022\t \n\031\032\031\023\n\ \031\b\031 \035 \024)Tj /Span<>> BDC ( )Tj EMC (\n\r\032\024\031\026 \n\031\025\024\031\f\022\030\022\032\r\005\212\027\235\ \200\022\026\022\031\023\027\032\020\033\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\020\030\236\005\021\020\025\023\025\031\026 \032\027\255\022\ \026\027 \024\031\033\031)Tj 0 Tw (-)Tj 0.053 Tw T* (\024\023\020\021\022\026\020 \033\031)Tj /Span<>> BDC ( )Tj EMC [(\007\020\024\023\031\023\027 \033\031\f\025\013\200 \031\023\021\027\023\ \031\021 )0.5(\031\033\r\200\031\f\022 \033\032\t\026\031\235 \n\022\213\n\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\027\025\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\f\031\025\b\022\032\031\021\020\025\025\013\026 \n\r\032\024\ \031\026 \225\035 )Tj 0.023 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\n\r\032\024\031\026 \n\031\025\024\031\f\022\030\022\032\r\005\212\027\235\ \200\022\026\022\031\023\027\032\020\033\022\022.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 283.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \023\031\023\020\f\017\025\020\t \025\027\031\020\030\236\005\021\020\025\ \023\025\020\t \023\027\032\020\033\022\t; \032\020\n \033\032\t\026\031\ \235 \n\022\213\n\022; \001; \026\027\024\023\025\031\032\020\024\033\032\ \031\024\023\032\020\025\027\025\025\013\235 \032\020\n \033\032\t\026\031\ \235 \n\022\213\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.033 Tc 0.009 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.014 Tw 9.181 0 Td ( \205\026\005\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\230., \202\035\036\022\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\206., \207\026\035\022\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \233\235\235\036\022\021\017\r\027\024\f\021\034 \021\024\021\ \026\035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\027\024\ \005 \021\036\030\026)Tj 0 Tc 0 Tw (-)Tj 0.022 Tc -0.035 Tw -9.186 -1.2 Td (\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\026\022\026 \023\030\016\n\024\005 \022\ \017\001\022\017: \030\036\031\035\034\021\026\021\t \030\026\027\007\024\ \n\017\017\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\ \026\027\017\016. )Tj /T1_0 1 Tf -0.022 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.035 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(116\226124.)22( )]TJ 0.023 Tc -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2026-25-1-116-124)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 130.2518 195.6332 Tm [(Ef)-31(f)-21(icacy of\022)-23.3(total neoadju)10(v)10(ant th)11(er)21(apy for r)31(ectal )]TJ 2.138 -1.167 Td [(cancer: r)30.9(esults of\022)-23.2(a\022)-23.3(r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 150.1292 Tm [(Rashid\022)-23.2(I.\022)-23.3(F)25(ay)21(z)10(ulin)]TJ 8.162 0 0 8.162 168.6908 154.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 173.3267 150.1292 Tm [(, Mikhail\022)-23.3(V)62(.\022)-23.3(Alek)11.1(see)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 291.0208 154.7912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 302.3415 150.1292 Tm [(, Ev)10(geny\022)-23.2(G.\022)-23.3(R)20(ybak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 420.9328 154.7912 Tm (1)Tj 14 0 0 14 425.5688 150.1292 Tm (, )Tj -25.336 -1.143 Td [(Ar)-20(t)-19.9(y)21(om\022)-23.3(A)-31(.\022)-23.3(Balkar)20.1(ov)]TJ 8.162 0 0 8.162 182.2283 138.7912 Tm (1)Tj 5.83 0 0 5.83 70.8661 119.79 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 116.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, 2)35(8, Moscow)22(, 1)125(23)58.1(423, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj ( )Tj 5.83 0 0 5.83 70.8661 95.79 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 92.46 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1-1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 577.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 568.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 19.9401 56.0378 Tm (116)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 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A)-14(bd)-16(ominal injur)-36.9(ies. P)40(ar)-22(t 2 )]TJ 0.071 Tw T* [(\(cl)-31(inic, dia)-17(gnosis, tr)-24(ea)15(tment\). )]TJ /T1_2 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC (Hygiene and Epidemiology)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2022;26\(2\):179\226187. \(In Russ.\).)Tj 0.265 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Clemens)Tj /Span<>> BDC ( )Tj EMC [(MS, P)30(ea)-17(ce)]TJ /Span<>> BDC ( )Tj EMC [(KM, Y)-28.9(i)]TJ /Span<>> BDC ( )Tj EMC [(F. R)13(ec)-16(t)15(al T)50(r)-32.9(auma: Ev)-16(idence-Based )]TJ 0.009 Tc -0.009 Tw -1.796 -1.25 Td [(P)34.6(r)-33.3(a)-17.4(c)-16.3(t)-32.4(ices. )]TJ /T1_2 1 Tf 0.352 Tw 4.696 0 Td [(Clinics in Colon and R)20.6(ectal Surg)11.6(er)-43.4(y)]TJ /T1_1 1 Tf [(. 2018;31:17\22623.)9( )]TJ 0 Tc 0 Tw -4.696 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-0037-1602182)Tj 0 0 0 1 k /GS1 gs 0.104 Tw -1.847 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bosar)-32(ge)]TJ /Span<>> BDC ( )Tj EMC (PL, Como)Tj /Span<>> BDC ( )Tj EMC [(JJ, F)10(o)14(x)]TJ /Span<>> BDC ( )Tj EMC [(N. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(pene)-12(tr)-33(a)15(t)-32(ing )]TJ -0.067 Tw -1.796 -1.25 Td [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal r)-24(ec)-16(t)15(al injur)-37(ies: An)]TJ /Span<>> BDC ( )Tj EMC [(Easter)-14.9(n Asso)-16(c)-23.9(ia)15(t)-32(ion for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Sur)-31.9(ger)-24(y )]TJ 0.276 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(T)50(r)-33(auma p)25(r)-33(a)-17(c)-16(t)-32(ice mana)-17(gement guidel)-31(ine. )]TJ /T1_2 1 Tf [(J T)56(rauma Acute Care )]TJ 0 Tw T* (Surg.)Tj /T1_1 1 Tf 0.023 Tw [(2016;80\(3\):546\226551. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/T)35(A.0000000000000953)]TJ 0 0 0 1 k /GS1 gs 0.282 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dild)42(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(J, O)-32(w)-12(a)15(t)-30(t)15(anap)32(anich)]TJ /Span<>> BDC ( )Tj EMC (N, Benjamin)Tj /Span<>> BDC ( )Tj EMC [(E.R., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15(t)-32(i)-15.9(ve )]TJ 0.333 Tw -1.796 -1.25 Td [(mana)-17(gement and outcomes of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-15.9(t)15(al injur)-36.9(ies af)-28(ter gunsho)17.1(t )]TJ 0.043 Tw T* [(w)-14(ounds in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(depl)30.1(oyed mil)-31(i)-24(t)15(ar)-23.9(y se)-12(t)-30(t)-32(ing ver)-10(sus c)-23.9(i)-16(v)-16(il)-31(ian tr)-32.9(auma cen)]TJ 0 Tw (-)Tj T* [(ter)-10(s. )]TJ /T1_2 1 Tf 0.111 Tw 2.172 0 Td [(J )0.5(T)56.1(rauma )0.5(Acute )0.6(Care )0.6(Surg.)]TJ /T1_1 1 Tf [( )0.5(2023; )0.6(95\(2S\):60\22665. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 21.726 0 Td (10.1097/)Tj -23.899 -1.25 Td [(t)15(a.0000000000004016)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.465 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (\207\026\001\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\216., \206\030\017\027\006\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \216\030\017\f\021\031\035\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0.008 Tc 0.349 Tw -1.847 -1.25 Td (\215\030\036\007\031\023\030\036\032\007\036\027\017\036 \023\024\f\035\036\ \024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tc 0 Tw (-)Tj 0.007 Tc 0.35 Tw T* (\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017 \002\024\035\034\ \027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\r\n\026\n\017 \023\030\016\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\002\024\007\024\004\027\024\005)7.1( )]TJ 0.001 Tc -0.001 Tw T* (\022\017\001\022\017. )Tj /T1_2 1 Tf 0.35 Tw 3.516 0 Td (\211\027\024\023\025\022\n \025\027\031\023\f\031\255\025\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\021\031\024\024\023\020\025\031\021\022\023\027\f\017\025\031\235 \200\022\ \032\r\032\b\022\022)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.128 Tw 25.539 80 Td [(2021;6\(1\):33\22636. / \200a)-17(cheev)]TJ /Span<>> BDC ( )Tj EMC [(V.H., )0.5(G)19.9(r)-36.9(intsov)]TJ /Span<>> BDC ( )Tj EMC [(A.G., )0.5(Khr)-37(istulenko)]TJ /Span<>> BDC ( )Tj EMC 25.753 0 Td (A.A., )Tj 0.145 Tw -25.753 -1.25 Td [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(post)17.1(oper)-33(a)15(t)-32(i)-16(ve com)10(pl)-31(ica)15(t)-31.9(ions in sur)-31.9(gical tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.227 Tw T* (ment of)Tj /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-23.9(t)-13(h injur)-37(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-23.9(ec)-16(tum and col)30(on. )]TJ /T1_2 1 Tf 0 Tw [(Jour)-14(nal )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Exper)-36.9(imental and Clinical Surg)12(er)-43(y)]TJ /T1_1 1 Tf (. 2021;6\(1\):33\22636. \(In Russ.\))Tj 0.104 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bost)-32(ick)]TJ /Span<>> BDC ( )Tj EMC [(P)35(J, Johnson)]TJ /Span<>> BDC ( )Tj EMC [(D)20(A, Hear)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(JF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-33(a)]TJ 0 Tw (-)Tj 0.023 Tw -1.796 -1.25 Td [(per)-37(i)-23.9(t)17(oneal r)-24(ec)-16(t)15(al injur)-37(ies. )]TJ /T1_2 1 Tf [(J N)18(atl Med Assoc)]TJ /T1_1 1 Tf (. 1993;85\(6\):460\226463)Tj 0.173 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\024\022\030\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\025.\202., \212\024\007\017\006\026)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\230. \222\030\026\r\027\017\021\036\035\034\027\t\005 )Tj 0.188 Tw -1.796 -1.25 Td (\026\027\026\035\017 \030\036\031\035\034\021\026\021\024\r \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \ \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033)Tj 0 Tw (-)Tj 0.012 Tc 0.448 Tw T* [(\001\017\027\027\t\n\017 )0.6(\023\024\r\030\036\032\007\036\027\017\016\n\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017. )]TJ /T1_2 1 Tf -0.012 Tw 19.714 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.225 Tw -19.714 -1.25 Td [(2016; 55\(S1\):38\22639. / P)10(okr)-32(ovsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(K.A., Dodi)-24(tsa)]TJ /Span<>> BDC ( )Tj EMC [(A.N., V)30(esel)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (D.I. )Tj 0.043 Tw T* [(Com)10(p)32(ar)-33(a)15(t)-32(i)-15.9(ve anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-23.9(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(p)32.1(a)14.9(t)-31.9(ients )]TJ 0.152 Tw T* [(wi)-24(t)-12.9(h )0.5(e)-18(xtr)-33(aper)-36.9(i)-24(t)17(oneal )0.6(lesions )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 13.231 0 Td [(t)-13(he )0.5(r)-23.9(ec)-16(tum. )]TJ /T1_2 1 Tf 0 Tw 5.266 0 Td [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.152 Tw [(. )0.6(2016; )]TJ 0.023 Tw -18.496 -1.25 Td (55\(S1\):38\22639. \(In Russ.\).)Tj 0.346 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\204\026\005\f\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC 5.484 0 Td [(\203.\202., )0.6(\222\026\024\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.441 0 Td [(\202.\202., )0.6(\217\024\n\026\013\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 7.703 0 Td [(\215.\203., )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.664 0 Td (\f\024\026\r\021. )Tj 0.194 Tw -25.088 -1.25 Td (\215\030\024\235\017\035\026\022\021\017\022\026 \024\f\035\024\032\027\036\ \027\017\005 \035\026\023\026\030\024\021\024\n\027\024\005 \030\026\027\ \t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\020\027\036\f\021\030\036\035\034)Tj 0 Tw (-)Tj 0.01 Tc 0.379 Tw T* (\027\024\005 \021\030\026\r\n\036 \032\017\r\024\021\026. )Tj /T1_2 1 Tf (\211\027\024\023\025\022\n \200\022\032\r\032\b\022\022 \022\026\027\025\ \022 \002.\002.)Tj /Span<>> BDC ( )Tj EMC (\216\032\027\n\031\021\020.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.118 Tw -27.638 -1.25 Td [(2023;182\(2\):46\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24884/0042-4625-2023-182-2-46-52)Tj 0 0 0 1 k /GS1 gs 0.118 Tw ( / )Tj 0.012 Tw T* [(Maistr)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(N.A., Sa)-24(zonov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., R)11(omashchenko)]TJ /Span<>> BDC ( )Tj EMC [(P.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(event)-32(ion )]TJ 0.071 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-32(ions fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ap)32(ar)-32(o)17(t)17(omy w)-14(ound in abd)-16(ominal gunsho)17(t )]TJ 0 Tw T* [(injur)-23.9(y. )]TJ /T1_2 1 Tf 0.111 Tw 3.019 0 Td [(Grek)13(ov\222s Bulletin )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y)]TJ /T1_1 1 Tf (. 2023;182\(2\):46\22652. \(In Russ.\). )Tj 0 Tw -3.019 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.24884/0042-4625-2023-182-2-46-52)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw -1.847 -1.25 Td (32.)Tj /Span<>> BDC ( )Tj EMC 1.805 0 Td (\233\005\002\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217.)Tj /Span<>> BDC ( )Tj EMC (\215\030\024\235\017\035\026\022\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\036 \023\024\007\027\017\b \f\021\024\n\026\035\ \034\027\t\b)2( )]TJ 0.006 Tc 0.349 Tw -1.805 -1.25 Td [(\024\f\035\024\032\027\036\027\017\005: \007\017\f\f. ... \022\026\027\007\ . \n\036\007. \027\026\031\022. \211\235\026, 2023; 140 \f. /)6( )]TJ 0 Tc 0.075 Tw T* (Jejbov)Tj /Span<>> BDC ( )Tj EMC (R.R.)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-24(event)-32(ion and tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(a)15(te st)17(omal com)10(pl)-31(ica)15(t)-31.9(ions: )]TJ 0.023 Tw T* (Cand. of)Tj /Span<>> BDC ( )Tj EMC [(med. sc)-24(i. diss. Uf)16(a, 2023; 140 p. \(In Russ.\))]TJ 0.038 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(il)16(gr)-36.9(im)]TJ /Span<>> BDC ( )Tj EMC [(C, McInt)-10(yr)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(R, Baile)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(M. P)35(r)-32(ospec)-16(t)-32(i)-16(ve audi)-23.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ar)-33(ast)17(omal )]TJ -0.075 Tw -1.796 -1.25 Td [(her)-15(nia: p)25(r)-23.9(ev)-15(alence and asso)-16(c)-23.9(ia)15(ted comor)-24(bidi)-23.9(t)-32(ies. )]TJ /T1_2 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the Colon )Tj 0.023 Tw T* [(& R)21(ectum)]TJ /T1_1 1 Tf [(. 2010; 53\(1\)6:1\22676. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/dcr.0b013e3181bdee8c)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.46 Tw T* [(3)0.5(4)0.5(.)]TJ /Span<>> BDC 1.333 0 Td ( )Tj EMC 0.512 0 Td [(\202)0.5(\035)0.5(\017)0.6(\n)0.5(\024)0.5(\r)]TJ /Span<>> BDC 3.167 0 Td ( )Tj EMC [(\215)0.5(.)0.5(\202)0.5(.)0.5(,)0.6( \213)0.5(\f)0.5(\036)0.6(\035)0.5(\036)0.5(\r)0.5(\017)0.5(\004)]TJ /Span<>> BDC 7.297 0 Td ( )Tj EMC [(\217)0.5(.)0.5(\200)0.5(,)0.5( \214)0.5(\017)0.5(\021)0.6(\r)0.5(\017)0.5(\027)0.5(\036)0.5(\027)0.6(\022)0.5(\024)]TJ /Span<>> BDC 8.048 0 Td ( )Tj EMC [(\202)0.5(.)0.5(\230)0.5(.)0.6(,)0.5( \017)]TJ /Span<>> BDC 3.962 0 Td ( )Tj EMC [(\f)0.6(\024)0.5(\026)0.5(\r)0.5(\021)0.5(.)13( )]TJ 0 Tc -0.004 Tw -24.319 -1.25 Td (\233\027\007\024\r\017\007\036\024\b\017\030\031\030\020\017\004\036\f\022\ \017\036 \021\036\b\027\024\035\024\020\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\030\020\036\027\021\027\t\b \026\002\024\035\036\r\026\027\017\016\ \b )Tj 0.115 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.821 0 Td [(\031\f\035\024\r\017\016\b )0.6(\024\021\007\026\035\036\027\027\024\020\024 )0.7(\020\026\030\027\017\024\027\026. )]TJ /T1_2 1 Tf 14.54 0 Td [(\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 )0.7(\255\r\032\025\020\f.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.008 Tc 0.349 Tw -15.362 -1.25 Td [(2)0.5(0)0.6(2)0.5(4)0.5(;)0.5(3)0.6(4)0.5(5)0.5(\()0.5(9)0.6(\))0.5(:)0.5(4)0.5(4)0.5(\226)0.6(4)0.5(6)0.5(.)0.6( d)-15.5(o)0.6(i)0.5(:)]TJ /Span<>> BDC 10.544 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.008 Tw [(1)0.6(0)0.5(.)0.5(5)0.6(2)0.5(4)0.5(2)0.5(4)0.5(/)0.6(0)0.5(0)0.5(2)0.5(6)0.6(9)0.5(0)0.5(5)0.5(0)0.5(_)0.6(2)0.5(0)0.5(2)0.5(4)0.6(_)0.5(3)0.5(4)0.5(5)0.6(_)0.5(9)0.5(_)0.5(4)0.5(4)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.357 Tw 16.061 0 Td ( / )Tj 0.033 Tw -26.605 -1.25 Td [(Al)-31(imov)]TJ /Span<>> BDC ( )Tj EMC [(P.A., Eselev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC [(R.V., L)-32(i)-24(t)-24(v)-15.9(inenko)]TJ /Span<>> BDC ( )Tj EMC [(A.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(ov)-15.9(ideosur)-32(gical )]TJ 0.335 Tw T* [(technol)30(o)-15.9(gies for ur)-32(gent diseases in a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(emo)17(te gar)-23.9(r)-37(ison. )]TJ /T1_2 1 Tf 0 Tw [(Militar)-43(y )]TJ 0.071 Tw T* [(Medical Jour)-14(nal)]TJ /T1_1 1 Tf [(. \(In Russ.\). 2024;345\(9\):44\22646. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.52424/002)Tj T* (69050_2024_345_9_44)Tj 0 0 0 1 k /GS1 gs 0.189 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gonzalez)Tj /Span<>> BDC ( )Tj EMC [(RP, F)20(al)-31(imir)-10(sk)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(ME, Holev)-15(ar)]TJ /Span<>> BDC ( )Tj EMC [(MR. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(esa)-17(cr)-33(al )]TJ -0.031 Tw -1.796 -1.25 Td [(dr)-33(aina)-17(ge in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(pene)-12(tr)-32.9(a)15(t)-32(ing r)-23.9(ec)-16(t)15(al injur)-37(ies. )]TJ /T1_2 1 Tf [(J T)56(rauma)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1998;45\(4\):656\226661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00005373-199810000-00002)Tj 0 0 0 1 k /GS1 gs 0.127 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\031\035\031\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\203. \221\016\032\036\035\026\016 \f\024\004\036\021\026\027\027\026\ \016 \021\030\026\r\n\026. \204\024\027\024\020\030\026\235\017\016. \222\ \215\002: )Tj -0.03 Tw -1.796 -1.25 Td [(\217\202 \253\217\031\f\f\022\017\005 \224\r\036\035\017\030\273, 2015; \ \f. 221\226223. / T)60(ul)35(upov)]TJ /Span<>> BDC ( )Tj EMC [(A.N. Sever)-24(e com)]TJ 0 Tw (-)Tj 0.095 Tw T* [(bined injur)-24(y. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mono)-16(gr)-32.9(aph. S)15(t. P)30(e)-12(ter)-10(sbur)-32(g: RA \236Russian Jeweler\237 )]TJ 0.023 Tw T* [(P)20(ubl. 2015; pp. 221\226223. \(In Russ.\).)]TJ 0.276 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)-19(ields)]TJ /Span<>> BDC ( )Tj EMC 2.847 0 Td [(A, )0.6(Sal)-31(im)]TJ /Span<>> BDC ( )Tj EMC 3.972 0 Td [(A. )0.6(Contem)10(por)-33(ar)-23.9(y )0.5(dia)-17(gnosis )0.6(and )0.6(mana)-17(gement )]TJ 0.074 Tw -8.615 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-15.9(t)15(al injur)-37(ies: wha)15(t you need t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(kno)-14(w. )]TJ /T1_2 1 Tf [(J. T)56(rauma Acute Care )]TJ 0 Tw T* (Surg.)Tj /T1_1 1 Tf 0.023 Tw [( 2024;97\(4\):497\226504. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/t)15.1(a.0000000000004352)]TJ 0 0 0 1 k /GS1 gs 0.33 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\035\017\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\206. \210\020\027\036\f\021\030\036\035\034\027\t\036 \030\026\027\ \036\027\017\016 \032\017\r\024\021\026. \210\f\024\002\036\027\027\024\f\ \021\017, )Tj 0.012 Tw -1.796 -1.25 Td [(\007\017\026\020\027\024\f\021\017\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.123 0 Td [(\035\036\004\036\027\017\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.838 0 Td [(\220\021\026\023\026\b )0.5(\n\036\007\017\006\017\027\f\022\024\005 )0.6(\220\r\026\022\031\026\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.945 0 Td (\f\024\r\030\036)Tj 0 Tw (-)Tj 0.206 Tw -24.906 -1.25 Td [(\n\036\027\027\t\b )0.6(\031\f\035\024\r\017\016\b: )0.6(\007\017\f\f. )0.5(... )0.6(\007-\030\026 )0.6(\n\036\007. )0.5(\027\026\031\022. )0.6(\222\215\002, )0.5(2016; )0.5(388 )0.6(\f. )0.5(/ )]TJ 0.111 Tw T* [(Al)-31(isov)]TJ /Span<>> BDC ( )Tj EMC [(P.G. Gunsho)17(t w)-14(ounds t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he abd)-15.9(omen. F)10(ea)15(tur)-23.9(es, dia)-17(gnost)-32(ics )]TJ 0.024 Tw T* [(and tr)-24(ea)15(tment a)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(st)15(a)-17(ges of)]TJ /Span<>> BDC ( )Tj EMC [(medical ev)-14.9(a)-17(cua)15(t)-32(ion in moder)-15(n condi)]TJ 0 Tw (-)Tj 0.023 Tw T* [(t)-32(ions. Dr. med. sc)-24(i. diss. S)15(t.P)30(e)-11.9(ter)-10(sbur)-32(g, 2016; 388 p. \(In Russ.\).)]TJ 0.177 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\036\030\036\b\024\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\203., \205\024\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\203., \003\031\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\025., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\023\t\021 \024\030\020\026)Tj 0 Tw (-)Tj 0.006 Tc 0.349 Tw -1.796 -1.25 Td (\027\017\026\006\017\017 \b\017\030\031\030\020\017\004\036\f\022\024\005\ \023\024\n\024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\024\020\027\036\f\021\030\036\035\034\027\t\b \030\026\027\036\027\017\016\ \b)6( )]TJ 0 Tc 0.095 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\024\030\031\032\036\027\027\t\b \022\024\027\235\035\017\022\021\026\ \b \027\026)Tj /Span<>> BDC ( )Tj EMC (\222\036\r\036\030\027\024\n \025\026\r\022\026\036. )Tj /T1_2 1 Tf 0.037 Tw T* (\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 \255\ \r\032\025\020\f)Tj /T1_1 1 Tf [(. 2009;7:4\2269. / P)30(er)-24(ekhod)-16(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.N., F)10(ok)-16(in )]TJ 0.162 Tw T* [(Y)35(u.N., Z)20(uev)]TJ /Span<>> BDC ( )Tj EMC [(V.K., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Sur)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4519-0018)Tj T* [(R)11(oman V. Eselev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3249-233X)Tj T* [(P)40(avel A. Al)-30.9(imov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3105-764X)Tj T* [(Oleg V. Bal)35.1(ur)-33(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7826-8056)Tj T* [(V)25(aler)-24(y N. Rumy)22.1(antsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7526-6282)Tj 0 -1.218 TD [(Ser)-32(ge)-11(y N. Bar)-23.9(d)42(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3804-6245)Tj 0 -1.218 TD [(K)25(onst)15(ant)-32(in Y)35.1(u. Z)25(o)17(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-0897-8921)Tj T* [(Dmi)-24(tr)-36.9(i)-16(i V. Obchinnikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8408-5301)Tj T* (Denis A. Dymnikov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4579-2027)Tj T* [(Mikhail S. K)25.1(or)-24(zhuk)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4579-2027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 542.1599 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.318 Tw 8 0 0 8 70.8661 529.3252 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\017\n)Tj /Span<>> BDC ( )Tj EMC (\230.\224., \215\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \204\031\f\026\017\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202. \222\r\024\036\r\030\036\n\036\027\027\026\016 \007\017\026\020\ )Tj 0 Tw (-)Tj 0.203 Tw -1.296 -1.25 Td (\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\026\035\034\027\026\016 \b\017\030\031\030\020\017\004\ \036\f\022\026\016 \021\026\022\021\017\022\026, \022\026\022 \024\f\027\ \024\r\026 \023\030\024)Tj 0 Tw (-)Tj 0.003 Tc 0.35 Tw 0 -1.25 TD (\235\017\035\026\022\021\017\022\017 \024\f\035\024\032\027\036\027\017\005\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC 12.9 0 Td [(\035\036\004\036\027\017\017 )0.5(\030\026\027\036\027\017\005 )0.5(\023\030\016\n\024\005 \022\017\001\022\017.)3( )]TJ /T1_3 1 Tf 0 Tc 0.195 Tw -12.9 -1.25 Td (\001\020\006\022\031\025\020\f\017\025\020\t \020\024\024\031\006\022\020\ \006\022\t \r\007\027\025\013\200)Tj /T1_0 1 Tf (. 2023;96\(1\):26\22629. / Kim)Tj /Span<>> BDC ( )Tj EMC (I.Y., )Tj 0.05 Tw T* [(P)40(anov)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Musail)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.A. T)35(imel)35(y dia)-17(gnosis and opt)-32(imal sur)-32(gical t)15(a)-17(c)]TJ 0 Tw (-)Tj -0.015 Tw T* [(t)-32(ics as t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(basis for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-32(ions in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment )]TJ 0.069 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC 1.116 0 Td [(r)-24(ec)-15.9(t)15(al )0.5(w)-14(ounds. )]TJ /T1_3 1 Tf 6.287 0 Td [(N)18(ational )0.6(Association )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 9.509 0 Td (Scientists)Tj /T1_0 1 Tf [(. )0.5(2023;96\(1\):26\226)]TJ 0.023 Tw -16.912 -1.25 Td (29. \(In Russ.\).)Tj 0.229 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\030\017\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC 4.102 0 Td [(\212.\200., )0.5(\025\030\033\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.013 0 Td [(\213.\200., )0.5(\202\035\036\022\f\036\036\r)]TJ /Span<>> BDC ( )Tj EMC 6.531 0 Td [(\212.\213., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.297 0 Td [(\f\024\026\r\021. )0.5(\200\024\036\027\027\024-)]TJ 0.197 Tw -21.239 -1.25 Td [(\023\024\035\036\r\026\016 \b\017\030\031\030\020\017\016. )0.5(\203\026\006\017\024\027\026\035\034\027\024\036 \030\031\022\024\r\024\007\ \f\021\r\024. )0.5(\204\024\f\022\r\026: \206\233\210\221\202\217-)]TJ 0.169 Tw T* [(\204\036\007\017\026, 2024; 1056 \f. / T)50(r)-37(ishk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(D.V., Kr)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC [(E.V., Alek)-10(seev)]TJ /Span<>> BDC ( )Tj EMC (D.E., )Tj 0.08 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mil)-31(i)-24(t)15(ar)-23.9(y F)-19(ield Sur)-32(ger)-24(y: Na)15(t)-32(ional guidel)-31(ines. M)-23.9(osco)-14(w: GEOT)35(AR-)]TJ 0.023 Tw T* [(Media P)20(ubl. 2024; 1056 p. \(In Russ.\).)]TJ 0.017 Tc 0.604 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.346 0 Td (\213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021)0.5(.)17( )]TJ 0 Tc 0.124 Tw -1.346 -1.25 Td (4D-\022\024\027\006\036\023\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \r\027\036\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\005\ )Tj 0.111 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \200\f\036 \035\017 \021\026\ \022 \024\007\027\024\027\026\004\027\024? )Tj /T1_3 1 Tf 0 Tw (\004\031\f\022\023\032\020\021\026\020)Tj /T1_0 1 Tf 0.111 Tw (. 2025;1:59\226)Tj 0.011 Tc 0.403 Tw T* [(66. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.24412/1819-1495-2025-1-59-66)Tj 0 0 0 1 k /GS1 gs 0.403 Tw [( / Y)30.1(eselev)-15.8(ich)]TJ /Span<>> BDC ( )Tj EMC [(R.V.,)11( )]TJ 0 Tc 0.06 Tw T* [(Bal)35(yur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(O.V., Rumy)22(antsev)]TJ /Span<>> BDC ( )Tj EMC [(V.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. 4 Dis a)Tj /Span<>> BDC ( )Tj EMC [(concept in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(gical )]TJ 0.178 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal r)-24(ec)-16(t)15(al w)-14(ounds. Is ever)-23.9(y)-16(t)-13(hingso)-16(clear? )]TJ /T1_3 1 Tf 0 Tw T* [(P)15(olytrauma)]TJ /T1_0 1 Tf 0.229 Tw [(. 2025;1:59\22666. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1819-1495-)Tj T* (2025-1-59-66)Tj 0 0 0 1 k /GS1 gs 0.339 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\230\r\004\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \210\r\004\017\027\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200. \210\f\027\024\r\027\t\036 \027\026\031\004\027\024-\023\030\026\ \022\021\017\004\036)Tj 0 Tw (-)Tj 0.326 Tw -1.296 -1.25 Td (\f\022\017\036 \017\021\024\020\017 \017\031\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \002\024\036\r\024\005 )Tj 0.333 Tw T* (\023\026\021\024\035\024\020\017\017 \023\036\030\017\024\007\026 \222\023\ \036\006\017\026\035\034\027\024\005 \r\024\036\027\027\024\005 \024\023\ \036\030\026\006\017\017. )Tj /T1_3 1 Tf 0 Tw (\002\016\021\027\024\023\022\t )Tj 0.273 Tw T* (\206\031\024\024\022\235\024\n\031\235 \211\031\027\025\025\031-\026\027\ \030\022\006\022\025\024\n\031\235 \020\n\020\030\027\026\022\022)Tj /T1_0 1 Tf (. 2024;43\(4\):457\226469. )Tj 0.004 Tc -0.004 Tw T* [(d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.194 0 Td [(10.17816/r)-16.1(mmar636549)]TJ 0 0 0 1 k /GS1 gs 0.35 Tw ( / Ivchenko)Tj /Span<>> BDC ( )Tj EMC 15.818 0 Td [(E.V., O)-24.1(vchinnikov)]TJ /Span<>> BDC ( )Tj EMC [(D.V.)3.9( )]TJ 0 Tc 0.046 Tw -18.012 -1.25 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(main sc)-24(ient)-32(if)-28(ic and p)25(r)-33(a)-17(c)-16(t)-32(ical r)-24(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he stud)17.1(y a)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Mil)-31(i)-24(t)15(ar)-23.9(y )]TJ 0.163 Tw T* [(Medical A)-25(cademy of)]TJ /Span<>> BDC ( )Tj EMC [(comba)15.1(t p)32(a)15(t)-13(hol)30(o)-16(g)16(y dur)-37(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Spec)-24(ial Mil)-31(i)-24(t)15(ar)-23.9(y )]TJ 0 Tw T* [(oper)-33(a)15(t)-32(ion. )]TJ /T1_3 1 Tf -0.098 Tw 4.378 0 Td [(R)22(ussian Militar)-42.9(y Medical Academ)11(y R)21(epor)-40(ts.)]TJ /T1_0 1 Tf ( 2024;43\(4\):457\226)Tj 0.023 Tw -4.378 -1.25 Td [(469. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.17816/r)-16(mmar636549)]TJ 0 0 0 1 k /GS1 gs 0.107 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\036\f\017\022\017\027)Tj /Span<>> BDC ( )Tj EMC 3.852 0 Td [(\230.\203., )0.5(\215\036\030\036\b\024\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.143 0 Td [(\222.\203., )0.5(\210\027\027\017\006\036\r)]TJ /Span<>> BDC ( )Tj EMC 6.079 0 Td [(\230.\213., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.083 0 Td [(\f\024\026\r\021. )0.5(\233\021\026\023\027\024\036 )]TJ 0.19 Tw -21.453 -1.25 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 )0.5(\030\026\027\036\027\017\005 \r\027\036\002\030\033\001\017\027\027\024\020\ \024 \024\021\007\036\035\026 \023\030\016\n\024\005 )]TJ 0 Tw T* (\022\017\001\022\017. )Tj /T1_3 1 Tf 3.197 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf 0.04 Tw [(. 2024;23\(3\):41\22649. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.197 -1.25 Td (7556-2024-23-3-41-49)Tj 0 0 0 1 k /GS1 gs -0.001 Tw [( / P)30(esik)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(I.N., P)30(er)-24(ekhod)-15.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.N., Onni)-24(tsev)]TJ /Span<>> BDC ( )Tj EMC (I.E., )Tj 0.307 Tw T* [(e)-12(t)15(al. )0.5(S)15(t)15.1(a)-17(ged sur)-31.9(gical )0.5(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 15.287 0 Td [(w)-14(ounds )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.964 0 Td [(t)-13(he )0.5(e)-18(xtr)-32.9(a-abd)-16(om)]TJ 0 Tw (-)Tj 0.015 Tc 0.549 Tw -20.251 -1.25 Td [(inal r)-24(ec)-16(tum. )]TJ /T1_3 1 Tf -0.015 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.549 Tw [(. 2024;23\(3\):41\22649. \(In Russ.\).)15.1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2024-23-3-41-49)Tj 0 0 0 1 k /GS1 gs -0.074 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\017\004\031\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\202.,\207\026\007\026\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\230., \204\026\030\022\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\200.\224., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\f\024\002\036\027\027\024\f\021\017 )Tj 0.255 Tw -1.296 -1.25 Td (\024\022\026\026\027\017\016 \f\023\036\006\017\026\035\017\017\030\024\ \r\026\027\027\024\005 \b\017\030\031\030\020\017\004\036\f\022\024\005 \ \023\024\n\024\013\017 \030\026\027\036\027\t\n )Tj 0.035 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \024\030\ \020\026\027\017\026\006\017\017 5-\020\024 \031\030\024\r\027\016. )Tj /T1_3 1 Tf 0 Tw (\211\031\027\025\025\031-)Tj 0.002 Tc 0.349 Tw -0 -1.25 Td (\026\027\030\022\006\022\025\024\n\022\235 \255\r\032\025\020\f)Tj /T1_0 1 Tf [(. 2023;344\(1\):4\22611. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.002 Tw (10.52424/002690)Tj 0 Tc 0 Tw T* (50_2023_344_8_4)Tj 0 0 0 1 k /GS1 gs 0.219 Tw [( / P)-24(ichugin)]TJ /Span<>> BDC ( )Tj EMC 12.884 0 Td [(A.A., )0.5(Bad)42(al)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.I., Mar)-23.9(k)10(ev)-16(ich)]TJ /Span<>> BDC ( )Tj EMC [(V.Y)35.1(u., )]TJ 0.056 Tw -12.884 -1.25 Td [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.119 0 Td [(al. )0.6(F)9.9(ea)15.1(tur)-24(es )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.094 0 Td [(t)-13(he )0.5(p)25.1(r)-32(ov)-16(ision )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.781 0 Td [(spec)-24(ial)-30.9(ized )0.5(sur)-32(gical )0.6(car)-24(e )0.6(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 11.403 0 Td [(t)-13(hose )]TJ -0.034 Tw -25.398 -1.25 Td [(w)-14(ounded in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(st)17.1(oma)-17(ch in a)]TJ /Span<>> BDC ( )Tj EMC [(mil)-30.9(i)-24(t)15(ar)-24(y medical or)-31.9(ganiza)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he 5t)-13(h )]TJ 0 Tw T* (level. )Tj /T1_3 1 Tf -0.001 Tw 2.423 0 Td [(Militar)-42.9(y Medical )0.6(Jour)-14(nal)]TJ /T1_0 1 Tf [(. )0.5(2023;344\(1\):4\22611. )0.5(\(In )0.5(Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 24.214 0 Td (10)Tj 2.417 55 Td (.52424/00269050_2023_344_8_4)Tj 0 0 0 1 k /GS1 gs 0.061 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hammer)Tj /Span<>> BDC ( )Tj EMC [(\330, Har)-24(per)]TJ /Span<>> BDC ( )Tj EMC [(D)20(A)15(T, R)-20(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(PD. P)25(A)35(S)-20.9(T: P)40(aleont)17.1(ol)30(o)-16(gical S)15(t)15(a)15(t)-32(ist)-32(ics )]TJ 0.161 Tw -1.296 -1.25 Td [(S)-16(of)-28(t)-32(w)-11.9(ar)-24(e P)40(a)-17(ck)-17(a)-16.9(ge for Educa)15.1(t)-32(ion and Da)15(t)15(a Anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0 Tw [(P)18(alaeontologia )]TJ T* (Electronica)Tj /T1_0 1 Tf 0.023 Tw (. 2001;4:9.)Tj 0.022 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Esposi)-24(t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(T)25(J, Ingr)-33(aham)]TJ /Span<>> BDC ( )Tj EMC [(A, L)35(uche)-12(t)-29.9(te)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(easons t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(omi)-23.9(t digi)]TJ 0 Tw (-)Tj 0.068 Tw -1.296 -1.25 Td [(t)15(al )0.5(r)-23.9(ec)-16(t)15(al )0.5(e)-18(x)-10.9(am )0.5(in )0.5(tr)-32.9(auma )0.5(p)32(a)15(t)-32(ients: )0.6(no )0.5(f)-28(inger)-10(s, )0.6(no )0.5(r)-24(ec)-16(tum, )0.6(no )0.5(useful )]TJ 0.212 Tw T* [(addi)-24(t)-32(ional infor)-15.9(ma)15(t)-32(ion. )]TJ /T1_3 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(T)56.1(rauma.)]TJ /T1_0 1 Tf ( 2005;59\(6\):1314\226)Tj 0.023 Tw T* [(1319. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.t)15(a.0000198375.83830.62)]TJ 0 0 0 1 k /GS1 gs 0.205 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)50(r)-22(ust)]TJ /Span<>> BDC ( )Tj EMC [(MD, V)30(ei)-24(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC [(J, Br)-31.9(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(CVR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-32.9(auma)15(t)-32(ic r)-24(ec)-16(t)15(al injur)-36.9(ies: )]TJ 0.27 Tw -1.296 -1.25 Td [(Is t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(combina)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(puted t)17(omo)-16(gr)-33(aphy and r)-37(igid p)25(r)-32(o)-16(c)-16(t)17(os)]TJ 0 Tw (-)Tj 0.294 Tw T* [(copy )0.6(suf)-56(f)-28(ic)-24(ient? )]TJ /T1_3 1 Tf 7.341 0 Td (The)Tj /Span<>> BDC ( )Tj EMC 1.896 0 Td [(Jour)-13.9(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.828 0 Td [(T)56(rauma )0.6(and )0.6(Acute )0.5(Care )0.5(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -14.065 -1.25 Td [(2018;85\(6\):1033\2261037. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/T)35(A.0000000000002070)]TJ 0 0 0 1 k /GS1 gs 0.071 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\212\036\007\031\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\222., \037\t\002\031\035\016\022)Tj /Span<>> BDC ( )Tj EMC (\206.\203. \232\026\f\021\027\026\016 \b\017\030\031\030\020\017\016 \n\036\ \b\026\027\017\004\036\f\022\017\b )Tj 0.327 Tw -1.796 -1.25 Td [(\023\024\r\030\036\032\007\036\027\017\005. \222\215\002: \206\017\023\023\ \024\022\030\026\021, 2011; 571 \f. / Dedushk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (V.S., )Tj 0.04 Tw T* (Cybuljak)Tj /Span<>> BDC ( )Tj EMC [(G.N. P)35(r)-37(i)-16(v)-15(a)15(te sur)-32(ger)-24(y of)]TJ /Span<>> BDC ( )Tj EMC [(mechanical injur)-37(ies. S)15(t. P)30(e)-12(ter)-10(sbur)-31.9(g: )]TJ 0.023 Tw T* [(Hippo)-16(cr)-32.9(a)15(tes P)20(ubl. 2011; 571 p. \(In Russ.\).)]TJ 0.239 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\231\031\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\230., \213\030\036\f\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \212\r\024\030\024\027\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200. \221\030\026\r\n\026 \023\030\016\n\024\005 )Tj 0.004 Tc 0.35 Tw -1.796 -1.25 Td (\022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016 \(\024\002\024\030 \035\017\021\ \036\030\026\021\031\030\t\). )Tj /T1_3 1 Tf (\211\027\024\023\025\022\n \205\020\025\n\023-)Tj 0 Tc 0.257 Tw T* (\004\027\023\027\032\240\r\032\b\024\n\031\b\031 \r\025\022\021\027\032\024\ \022\023\027\023\020. \215\027\030\022\006\022\025\020.)Tj /T1_0 1 Tf ( 2013; \222\036\030. 11. \200\t\023. )Tj 0.089 Tw T* [(1, \f. 127\226133. / S)-16(hugaev)]TJ /Span<>> BDC ( )Tj EMC [(A.I., Er)-33(ast)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.M., Dvor)-23.9(y)22(ank)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(D.V. R)13(ec)-16(t)15(al )]TJ 0.033 Tw T* [(tr)-33(auma in c)-24(i)-15.9(v)-16(il)-31(ian t)-31.9(ime \(l)-31(i)-23.9(ter)-33(a)15(tur)-23.9(e r)-24(ev)-16(iew\). )]TJ /T1_3 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC [(S)28(t. P)15(etersburg )]TJ 0.023 Tw T* [(S)28(tate U)22(niv)13(ersity)]TJ /T1_0 1 Tf (. 2013; \(1\):127\226131. \(In Russ.\).)Tj 0.291 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\222\036\007\036\035\034\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\222., \212\024\030\024\r\f\022\017\b)Tj /Span<>> BDC ( )Tj EMC (\206.\203. \204\031\035\034\021\017\f\030\036\024\r\026\016 \022\024\n\023\ \034\033)Tj 0 Tw (-)Tj 0.043 Tw -1.796 -1.25 Td (\021\036\030\027\026\016 \021\024\n\024\020\030\026\235\017\016 \r\f\036\ \020\024 \021\036\035\026 \022\026\022 \220\021\026\023 \030\026\027\027\ \036\005 \007\017\026\020\027\024\f\021\017\022\017 \023\024\035\017)Tj 0 Tw (-)Tj 0.151 Tw T* (\021\030\026\r\n\t \(\024\002\024\030 \035\017\021\036\030\026\021\031\030\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\t\005 \024\023\t\021 \017\f\023\024\035\034\ \024\r\026\027\017\016\). )Tj /T1_3 1 Tf 0.314 Tw T* (\206\020\030\022\031\f\031\b\022\t)Tj /Span<>> BDC ( )Tj EMC 5.346 0 Td [(\227 )0.5(\033\032\020\n\023\022\n\020)]TJ /T1_0 1 Tf [(. )0.5(2017;65\(5\):22\22630. )0.6(/ Sedelnikov)]TJ /Span<>> BDC ( )Tj EMC 20.588 0 Td (S.S., )Tj 0.018 Tw -25.935 -1.25 Td [(Dor)-32(ovsk)-15.9(ikh)]TJ /Span<>> BDC ( )Tj EMC [(G.N. Whole-Bod)17.1(y mul)56(t)-32(ide)-11.9(tec)-16(t)17(or com)10(puted t)17(omo)-16(gr)-33(aphy as )]TJ -0.034 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(st)15(a)-17(ge of)]TJ /Span<>> BDC ( )Tj EMC [(ear)-30(l)35(y dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(pol)35(y)-16(tr)-33(auma \(r)-24(ev)-15.9(iew of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-24(ter)-32.9(a)15(tur)-24(e and o)-14(wn )]TJ 0 Tw T* [(e)-18(xper)-36.9(ience\). )]TJ /T1_3 1 Tf 0.023 Tw 5.341 0 Td [(R)20(adiology)]TJ /Span<>> BDC ( )Tj EMC [(\227 p)46(ractice. )]TJ /T1_0 1 Tf (2017;65\(5\):22\22630. \(In Russ.\).)Tj 0.013 Tc 0.459 Tw -5.341 -1.25 Td [(1)0.5(3)0.6(.)]TJ /Span<>> BDC 1.333 0 Td ( )Tj EMC 0.512 0 Td [(\221)0.5(\017)0.6(\n)0.5(\036)0.6(\030)0.5(\002)0.5(\031)0.6(\035)0.5(\026)0.6(\021)0.5(\024)0.6(\r)]TJ /Span<>> BDC 5.912 0 Td ( )Tj EMC [(\200)0.5(.)0.6(\204)0.5(.)0.5(,)0.6( \206)0.6(\026)0.5(\030)0.5(\036)0.6(\036)0.5(\r)]TJ /Span<>> BDC 6.345 0 Td ( )Tj EMC [(\217)0.5(.)0.6(\203)0.5(.)0.5(,)0.6( \205)0.6(\026)0.5(\016)0.6()0.5(\024)0.6(\r)]TJ /Span<>> BDC 6.416 0 Td ( )Tj EMC [(\217)0.6(.)0.5(\217)0.6(.)0.5(,)0.6( \017)]TJ /Span<>> BDC 3.802 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.6(\r)0.5(\021)0.6(.)13( )]TJ 0.017 Tc 0.626 Tw -24.32 -1.25 Td (\216\017\030\031\030\020\017\004\036\f\022\026\016 \021\026\022\021\017\022\ \026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\021\030\026\r\n\026\021\017\004\036\f\022\017\b \023\024\r\030\036\032\007\ \036\027\017\016\b)17.1( )]TJ 0.011 Tc 0.408 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. )Tj /T1_3 1 Tf (\215\027\030\022\006\022\025\024\n\022\235 \020\f\017\026\020\025\020\200\ )Tj /T1_0 1 Tf [(. 2015;36\(1\):50\22662. /)11( )]TJ 0 Tc 0.1 Tw T* [(T)35(imer)-24(bul)-15.9(a)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.M., Gar)-24(eev)]TJ /Span<>> BDC ( )Tj EMC [(R.N., F)20(a)15(y)22(a)-24(zov)]TJ /Span<>> BDC ( )Tj EMC [(R.R., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32(gical t)15(a)-17(c)-16(t)-32(ics )]TJ -0.001 Tw T* [(for tr)-33(auma)15(t)-32(ic injur)-37(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he col)30(on. )]TJ /T1_3 1 Tf (Medical almanac)Tj /T1_0 1 Tf (. 2015;36\(1\):50\226)Tj 0.023 Tw T* (62. \(In Russ.\).)Tj 0.03 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Johnson)Tj /Span<>> BDC ( )Tj EMC (EK, Judge)Tj /Span<>> BDC ( )Tj EMC [(T, L)35.1(und)17(y)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnost)-32(ic pel)30(v)-16(ic com)10(puted )]TJ 0.023 Tw -1.796 -1.25 Td [(t)17(omo)-16(gr)-33(aphy in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al-injur)-24(ed comba)15(t casual)56(t)-10(y. )]TJ /T1_3 1 Tf [(Militar)-43(y Medicine.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2008;173\(3\):293\226299. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.7205/milmed.173.3.293)Tj 0 0 0 1 k /GS1 gs 0.129 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Khan)Tj /Span<>> BDC ( )Tj EMC (MS, Khan)Tj /Span<>> BDC ( )Tj EMC [(BM, Na)-23.9(z)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Is est)-32(ima)15.1(ted bulle)-11.9(t tr)-33(ajec)-16(t)17(or)-23.9(y )]TJ -0.019 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(r)-24(el)-31(iable p)25(r)-23.9(edic)-16(t)17(or of)]TJ /Span<>> BDC ( )Tj EMC [(sever)-24(e injur)-24(y? Case r)-23.9(epor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(t)-12.9(hor)-33(a)-17(co-abd)-16(om)]TJ 0 Tw (-)Tj 0.097 Tw T* [(inal gunsho)17(t wi)-24(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)17(tr)-33(a)-17(c)-15.9(ted tr)-32.9(ajec)-16(t)17(or)-24(y mana)-17(ged nonoper)-33(a)15(t)-32(i)-15.9(vel)35(y. )]TJ /T1_3 1 Tf 0.023 Tw T* [(BMCR)21(es N)17(o)13(tes)]TJ /T1_0 1 Tf [(. 2013;63\(6\):1\2264. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1756-0500-6-63)Tj 0 0 0 1 k /GS1 gs 0.043 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(avenson)]TJ /Span<>> BDC ( )Tj EMC (GS, Cohen)Tj /Span<>> BDC ( )Tj EMC [(A. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15.1(al injur)-37(ies. )]TJ /T1_3 1 Tf 0 Tw [(Amer)-36.9(ican )]TJ 0.023 Tw -1.796 -1.25 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y. )]TJ /T1_0 1 Tf 0 Tw (1971;122\(2\):226\226230)Tj 0.017 Tc 0.612 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.863 0 Td (\221\030\017\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \025\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \232\031\023\030\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\215., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, 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0 obj <> endobj 927 0 obj <> endobj 926 0 obj <> endobj 925 0 obj <> endobj 858 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.309 Tw 10 0 0 10 42.5197 724.8299 Tm (\030\031\021\017\027\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\ \017\016 \023\030\036\f\035\036\007\031\033\021 \006\036\035\034 \023\030\ \024\235\017)Tj 0 Tw (-)Tj -0.035 Tw 0 -1.218 TD (\035\026\022\021\017\022\017 \017\027\235\036\022\006\017\024\027\027\t\b\ \024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\024\030\024\027\t \ \022\035\036\021)Tj 0 Tw (-)Tj 0.096 Tw T* (\004\026\021\022\017 \021\026\026. \210\007\027\026\022\024 11 \030\036\ \f\023\024\027\007\036\027\021\024\r \023\031\021\036\n \030\031\021\017\ \027\027\024)Tj 0 Tw (-)Tj 0.271 Tw T* (\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \030\026\f\f\004\ \017\021\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\031\033 )Tj 0.093 Tw T* (\007\017\026\020\027\024\f\021\017\022\031 \017\027\235\036\022\006\017\024\ \027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\024\030\ \024\027\t )Tj 0.219 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r \021\026\026, \026)Tj /Span<>> BDC ( )Tj EMC (10 \030\036\f\023\024\027\007\036\027\021\024\r )Tj 0.695 Tw 0 -1.218 TD (\026\030\020\031\n\036\027\021\017\030\024\r\026\035\017 \r\t\023\024\035\ \027\036\027\017\036 \007\026\027\027\024\020\024 \220\035\036\n\036\027\ \021\026 )Tj -0.014 Tw 0 -1.218 TD (\025\024\027\006\036\023\006\017\017 \030\036\026\035\017\026\006\017\036\ \005 \021\030\036\002\024\r\026\027\017\005 \030\036\020\035\026\n\036\027\ \021\017\030\031\033)Tj 0 Tw (-)Tj 0.107 Tw T* (\013\017\b \007\024\022\031\n\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\017\005 \f\021\026\030\001\036\020\024 \n\036\007\017\ \006\017\027\f\022\024\020\024 )Tj 0 Tw T* (\027\026\004\026\035\034\027\017\022\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 578.6938 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.214 Tw 10 0 0 10 42.5197 554.3378 Tm (\203\036\007\024\f\021\026\021\024\004\027\026\016 \f\024\020\035\026\f\024\ \r\026\027\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.289 Tw T* (\001\017\027\f\021\r\024 \r\024\023\030\024\f\024\r \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \n\036\021\024\007\024\r \007\017\026\020\027\024\f\ \021\017\022\017 )Tj 0.027 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\017 \b\017\030\031\030\020\017\004\036\f\022\024\ \020\024 \035\036\004\036\027\017\016 \200\002\217\215\025 \f\r\017\007\036\ \021\036\035\034)Tj 0 Tw (-)Tj 0.023 Tw T* (\f\021\r\031\036\021 \024\002 \024\021\f\031\021\f\021\r\017\017 \036\007\ \017\027\024\020\024 \026\035\020\024\030\017\021\n\026 \007\017\026\020\ \027\024\f\021\017\022\017 )Tj 0.055 Tw T* (\200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233. \204\017\027\017\n\026\035\034\027\024\036 \022\024\035\017\ \004\036\f\021\r\024 \030\036\f\023\024\027\007\036\027)Tj 0 Tw (-)Tj 0.293 Tw T* (\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233 \023\030\036\007\023\024\004\017\021\026\035\024 \022\024\n\ \023\034\033\021\036\030\027\031\033 \021\024\n\024\020\030\026)Tj 0 Tw (-)Tj -0.001 Tw T* (\235\017\033 \007\035\016 \007\017\026\020\027\024\f\021\017\022\017 \200\ \002\217\215\025, \004\021\024, \r\036\030\024\016\021\027\024, \024\021\ \030\026\032\026\036\021 )Tj 0.394 Tw T* (\027\036\007\024\024\006\036\027\022\031 \007\017\026\020\027\024\f\021\017\ \004\036\f\022\024\020\024 \023\024\021\036\027\006\017\026\035\026 \r\027\ \031\021\030\017)Tj 0 Tw (-)Tj 0.301 Tw T* (\023\030\024\f\r\036\021\027\t\b \n\036\021\024\007\024\r \017\f\f\035\036\ \007\024\r\026\027\017\016 \023\030\016\n\024\005 \022\017\001\022\017. \ )Tj 0.153 Tw T* [(\215\030\024\r\036\007\036\027\027\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\r\t\016\r\017\035\024 )0.6(\030\026\027\024\030\024\007\027\024\f\021\034 )]TJ 0.25 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \021\026\022\021\017\022\ \017 \035\036\004\036\027\017\016 \200\002\217\215\025, \022\026\022 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.012 Tw T* (\007\036\035\034\027\t\b \233\204\233, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \r\f\036\b \211\204\215 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n. \203\036\026\r\017\f\017\n\024 )Tj 0.131 Tw T* [(\024\021 )0.5(\f\021\026\032\026 )0.5(\b\017\030\031\030\020\024\r )0.5(\023\030\024\f\035\036\032\017\r\026\035\024\f\034 )0.5(\030\026\035\017\004\017\036 )0.6(\r\020\035\016)]TJ 0 Tw (-)Tj 0.167 Tw T* (\007\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC 3.242 0 Td [(\006\036\035\036\f\024\024\002\030\026\027\024\f\021\034 )0.5(\030\036\026\035\017\026\006\017\017 )0.5(\021\036\b )0.5(\017\035\017 \017\027\t\b )]TJ 0.263 Tw -3.242 -1.218 Td [(\220\035\036\n\036\027\021\024\r )0.6(4D\226\022\024\027\006\036\023\006\017\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.4 0 Td [(\200\002\217\215\025, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.873 0 Td (\n\036\021\024\007\017\022\031 )Tj 0 Tw -18.273 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\034 \017\b\ \r\t\023\024\035\027\036\027\017\016.)Tj 0.244 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\024\r\t\001\036\027\017\016 \022\026\004\036\f\ \021\r\026 \024\022\026)Tj 0 Tw (-)Tj 0.661 Tw T* (\t\r\026\036\n\024\005 \b\017\030\031\030\020\017\004\036\f\022\024\005\ \023\024\n\024\013\017 \023\024\f\021\030\026\007\026\r\001\017\n )Tj 0.143 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \027\036\024\002\b\024\007\017\n\024 \031\021\024\004\ \027\036\027\017\036 \021\026\022\021\017\004\036\f\022\017\b \023\024\007\ \b\024)Tj 0 Tw (-)Tj 0.085 Tw T* (\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\017\b \026\f\023\036\022\021\024\r \017\ \b \023\030\026\022\021\017\004\036\f\022\024\005 \030\036\026\035\017)Tj 0 Tw (-)Tj 0.135 Tw T* (\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233. \210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\t\b \023\031\021\036\005 \030\036\001\036\027\017\016\ )Tj 0.263 Tw T* (\007\026\027\027\024\005 \026\007\026\004\017 \016\r\035\016\036\021\f\016\ \023\030\024\r\036\007\036\027\017\036 \022\024\035\035\036\022\021\017\ \r\027\024\005 )Tj 0.135 Tw T* (\220\022\f\023\036\030\021\027\024\005 \024\006\036\027\022\017 \n\036\021\ \024\007\024\n \212\036\035\235\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\035\036\004\036\027\017\036\n )Tj 0.03 Tw T* [(\020\030\031\023\023\t \220\022\f\023\036\030\021\024\r. \215\030\017\027\ \016\021\017\036 )0.5(\022\024\027\f\036\027\f\031\f\027\024\020\024 \030\036\001\036\027\017\016\ )]TJ 0.127 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \f\023\024\030\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\t\n \r\024\023\030\024\f\026\n \007\017\026\020\027\024\f\ )Tj 0 Tw (-)Tj 0.301 Tw T* (\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\017 \035\036\004\036\027\017\016 \023\024\r\024\ \035\017\021 \031\035\031\004\001\017\021\034 \027\036\023\024)Tj 0 Tw (-)Tj 0.066 Tw T* [(\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t )0.5(\035\036\004\036\027\017\016 \007\026\027\027\024\005 \022\026\021\036\020\ \024\030\017\017 )]TJ 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj /T1_3 1 Tf T* (\224\035\032\027\017\031\032\022\025\017\255\020\205: )Tj /T1_1 1 Tf 0.738 Tw 8.544 0 Td (\025\024\035\035\036\022\021\017\r \026\r\021\024\030\024\r \r\t\030\026\ \032\026\036\021 )Tj 0.23 Tw -8.544 -1.218 Td (\002\035\026\020\024\007\026\030\027\024\f\021\034 \230\002\030\026\020\017\ \n\024\r\031 \202\035\036\022\f\026\027\007\030\031 \217\036\235\026\021\ \024\r\017\004\031 )Tj 0 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\024\021\024\r\022\031 \017\035\035\033\f\021\030\026\006\ \017\017 \022)Tj /Span<>> BDC ( )Tj EMC (\030\031\022\024\023\017\f\017.)Tj /T1_3 1 Tf T* [(GRA)28(T)-23(ITUDE: )]TJ /T1_1 1 Tf 0.144 Tw 5.35 0 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC (team of)Tj /Span<>> BDC ( )Tj EMC [(aut)-13(hor)-10(s e)-18(xp)25(r)-24(esses i)-24(ts gr)-33(a)15(t)-32(i)]TJ 0 Tw (-)Tj 0.104 Tw -5.35 -1.218 Td [(tude t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Ibr)-33(a)-17(gimov Ale)-17.9(x)-11(ander R)13(ef)16(a)15(t)17(ov)-16(ich for p)25(r)-24(ep)32(ar)-36.9(ing )]TJ 0 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ill)35.1(ustr)-33(a)15(t)-32(ions for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(manuscr)-36.9(ipt.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.522 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf [( \205)27.6(\r)-4.3(\032\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)7.3(\003)-2.3(.)7.8(, )]TJ 0 Tw T* [(\036)24.3(\024)9.8(\027)-20.6(\f)3.3(\027)6.6(\021)5.5(\022)19.4(\007)]TJ /Span<>> BDC ( )Tj EMC [(\206)93.9(.)28.5(\211)24.3(.)7.8(, \202)15.6(\031)4.9(\032)7.9(\255)-9.1(\r)8.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.4(.)43.7(\205)-2.1(.)]TJ /T1_1 1 Tf 0.572 Tw T* [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.01 Tc 0.582 Tw [( \220)-3.5(\013)-2.1(\026\025\022)-2.3(\n\031\021)]TJ /Span<>> BDC 19.396 0 Td ( )Tj EMC [(\220)-8.6(.)-2.7(\003)-12.3(.)-2.2(,)-10( )]TJ 0 Tc 0 Tw -19.396 -1.218 Td [(\221)5(\020)-5.2(\f)9.7(\005)4.5(\032)3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\217)27.6(.)28.5(\211)24.3(.)7.8(, \207)8(\031)3(\023)4.1(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)27.5(\224)26.6(.)7.8(, \206)-10.5(\r)7.2(\026)8.8(\t)10.2(\025)10.1(\006)2.7(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)29.3(\001)28.8(.)]TJ /T1_1 1 Tf 0.894 Tw 23.244 64.543 Td [(\222)17.2(\021)-21.5(\026)-11.8(\021)-17.7(\017)-2.4(\f)-36(\021)-17.7(\017)4.6(\004)-8.2(\036)-10.4(\f)-1.6(\022)-19.1(\026)-21.1(\016 \024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\026\027)-0.6(\026)-33.1(\035)2.2(\017)2.7( \007)-20.1(\026\027)1.7(\027)1.7(\t)-12.8(\b)-9.4(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.01 Tc 0.01 Tw 0 -1.218 TD [(\221)-5(\020)-8.2(\032)-9.9(\030)-5.1(\020)-5.2(\n\031\021)]TJ /Span<>> BDC 3.824 0 Td ( )Tj EMC [(\205)-12.1(.)19.3(\001)18.9(.)-2.2(,)-10( \003)-27.3(\f\022)-5.4(\026)-5.9(\031\021)]TJ /Span<>> BDC 5.228 0 Td ( )Tj EMC [(\004)19.3(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -9.052 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \036)14.3(\024\027)-30.5(\f)-6.7(\027)-3.4(\021)-4.5(\022)9.3(\007)]TJ /Span<>> BDC 3.85 0 Td ( )Tj EMC [(\206)83.9(.)18.5(\211)14.3(.)-2.1(,)-10( \003)-27.3(\f\022)-5.4(\026)-6(\031\021)]TJ /Span<>> BDC 5.186 0 Td ( )Tj EMC [(\004)19.3(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -16.729 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \205)17.6(\r)-14.3(\032)-9.9(\031\021)]TJ /Span<>> BDC 9.622 0 Td ( )Tj EMC [(\220)-8.6(.)-2.7(\003)-12.3(.)-2.1(,)-10( \217)-3.2(\021)6.1(\007\022)-2.7(\025\025\022)-2.3(\n\031\021)]TJ /Span<>> BDC 7.152 0 Td ( )Tj EMC [(\220)-8.6(.)18.5(\211)14.3(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -16.775 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.276 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.8(y)-11.8(:)]TJ /T1_4 1 Tf [( D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(ov)33.6(, )]TJ 0 Tw 0 -1.218 TD [(R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(E)-3.6(s)4.9(e)-1.9(l)4.8(e)-4(v)-28.6(i)2.6(c)1.9(h)-6(, M)10.5(i)8.4(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.4(o)1.3(r)-14.6(z)8.1(h)8.2(u)4.6(k)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0.088 Tw -15.798 -1.218 Td [(D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-10.9(ym)4.7(n)6.2(i)7.9(k)12.9(ov)33.5(, O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(al)4.3(u)6.1(r)7.7(a)-14(, K)13.3(on)8.1(s)-10.7(t)2.3(a)-0.8(n)3.8(t)-25.2(i)8.4(n)]TJ /Span<>> BDC ( )Tj EMC [(U)25.4(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.1(o)1.4(t)1.4(o)-0.6(v)33.6(, )]TJ -0.005 Tc 0.005 Tw T* [(V)20.9(a)-5.1(le)-6.7(r)-40.3(i)-5.1(y)]TJ /Span<>> BDC 2.664 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(R)5.2(umy)-1.2(a)-5.8(n)-1.2(t)-34.1(se)-9(v)]TJ /T1_1 1 Tf -0.002 Tc 1.448 Tw -3.752 -1.218 Td [(S)5(t)-29.7(a)-10.4(t)-39.4(i)0.7(s)-21.9(t)-39.4(i)3.2(c)-13.8(a)-3.5(l)-2( d)-1.3(a)-10.4(t)-29.7(a)-2( p)-5.8(r)-8(o)-9(c)-1.8(e)-15.3(s)-14.8(s)-18.6(i)5.1(n)-3.9(g)-1.9( an)-6.6(d)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 22.11 0 Td ( )Tj -22.11 -1.218 Td [(S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(N)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(ar)1.4(d)1.9(a)1.7(k)13(o)-0.6(v)33.6(, P)30.8(a)-4.4(v)6.6(e)-1.9(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.7(l)4.3(i)8.4(m)-1.1(o)-0.6(v)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf [( R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(E)-3.5(s)4.9(e)-1.9(l)4.8(e)-4(v)-28.6(i)2.6(c)1.8(h)-6(, P)30.9(a)-4.4(v)6.6(e)-1.9(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.3(i)8.5(m)-1.1(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf -0.006 Tc 0.006 Tw 3.238 0 Td [( D)-8(mi)-5(t)-11.4(r)-41.3(i)-2.6(i)]TJ /Span<>> BDC 2.951 0 Td ( )Tj EMC [(A)-18.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(S)9.8(ur)-3.6(o)-6.5(v)27.6(,)-6( D)-8(mi)-5.1(t)-11.4(r)-41.2(i)-2.6(i)]TJ /Span<>> BDC 5.491 0 Td ( )Tj EMC [(V)47.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(O)-18.2(v)1.4(c)-4.2(hi)2.5(n)-0.8(ni)1.9(k)6.9(o)-6.6(v)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -13.714 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.311 Tw T* [(\222\031\030\024\r )0.5(\212\n\017\021\030\017\005 )0.6(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 13.948 0 Td [(\227 )0.5(\007.\n.\027., )0.6(\023\030\024\235\036\f)]TJ 0 Tw (-)Tj 0.238 Tw -13.948 -1.218 Td (\f\024\030, \027\026\004\026\035\034\027\017\022 \022\026\235\036\007\030\ \t \r\024\036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\ \017\017 )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.038 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 02-4519-0018; )Tj 0 Tw T* (SPIN-\022\024\007: 5346\2261613)Tj 0.124 Tw T* (\213\f\036\035\036\r\017\004 \217\024\n\026\027 \200\035\026\007\017\n\017\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \027\026\004\026\035\034\027\017\022 )Tj 0.238 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 \022\035\017\027\017\022\017 \022\026\235\036\007\030\t\ \r\024\036\027)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\ \036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\ \036\n\017\017 )Tj 0.003 Tw T* (\017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, \232\210\211\200\210 \253\222\026\ \027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005 )Tj 0.326 Tw T* [(\n\036\007\017\022\024-\f\024\006\017\026\035\034\027\t\005 )0.6(\017\027\f\021\017\021\031\021\273, )0.6(\020.)]TJ /Span<>> BDC ( )Tj EMC 14.925 0 Td (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; )Tj 0 Tw -14.925 -1.218 Td (ORCID 0000-0003-3249-233X; SPIN-\022\024\007: 1037\2268736)Tj 0.222 Tw T* (\202\035\017\n\024\r \215\026\r\036\035 \202\035\017\n\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\031\001\026\021\036\035\034 \024\030\007\017\027\026\021\031\ \030\t )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.042 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0009-00\ 07-3105-764X; )Tj 0 Tw T* (SPIN-\022\024\007: 5928\2263805)Tj 0.327 Tw T* (\207\026\035\033\030\026 \210\035\036\020 \200\026\035\036\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030\001\017\005 \023\030\036)Tj 0 Tw (-)Tj 0.821 Tw T* (\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\ \036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017\ )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.337 Tw T* [(\217\205, )0.5(\232\210\211\200\210 )0.6(\253\222\026\027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005\ )0.5(\n\036\007\017\022\024-\f\024\006\017\026\035\034)]TJ 0 Tw (-)Tj 0.006 Tw T* (\027\t\005 \017\027\f\021\017\021\031\021\273, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-)Tj 0 Tw T* (7826-8056; SPIN-\022\024\007: 9260\2269850)Tj 0.229 Tw T* (\217\031\n\016\027\006\036\r \200\026\035\036\030\017\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \023\030\036\023\024\007\026)Tj 0 Tw (-)Tj 0.2 Tw T* (\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\036\027\027\024\ -\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\036\027\ \027\024-)Tj 0.429 Tw T* (\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\036\n\017\017 \ \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, )Tj 0.571 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-7526-6282; )Tj 0 Tw T* (SPIN-\022\024\007: 8166\2269820)Tj 0.19 Tw T* (\207\026\030\007\026\022\024\r \222\036\030\020\036\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \023\030\036\023\024\007\026\r\026)Tj 0 Tw (-)Tj 0.253 Tw T* (\021\036\035\034 \022\026\235\036\007\030\t \027\036\030\r\027\t\b \002\024\ \035\036\027\036\005, \022\026\235\036\007\030\t \027\036\235\030\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\030\036\027\021\027\024\005 \021\036\030\026\023\017\017\ \200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 )Tj -0.001 Tw T* (\026\022\026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; )Tj 0 Tw T* (ORCID 0000-0002-3804-6245; SPIN-\022\024\007: 2351-4096)Tj 0.002 Tw T* (\003\024\021\024\r \025\024\027\f\021\026\027\021\017\027 \224\030\034\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\031\001\026\021\036\035\034 \024\030\007\017\027\026\021\031\ \030\t )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0009-00\ 05-0897-8921)Tj 0.513 Tw T* (\210\r\004\017\027\027\017\022\024\r \212\n\017\021\030\017\005 \200\026\ \035\036\030\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024)Tj 0 Tw (-)Tj 0.354 Tw T* (\006\036\027\021, \027\026\004\026\035\034\027\017\022 \024\021\007\036\035\ \026 \024\030\020\026\027\017\026\006\017\017 \027\026\031\004\027\024\005\ \030\026)Tj 0 Tw (-)Tj 0.333 Tw T* (\002\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\024\021\024\r\022\017 \027\026\031\004\027\024-\023\036\ \007\026\020\024\020\017\004\036\f\022\017\b \022\026\007\030\024\r )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.6396 56.0378 Tm (113)Tj ET endstream endobj 856 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.192 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\024\035\024\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017-\007\024\f\021\031\023\026 \016\r\035\016\036\021\f\016 \027\ \036\023\030\036\030\t\r\027\t\005 )Tj 0.437 Tw 0 -1.218 TD (\n\024\027\017\021\024\030\017\027\020 \f\024\f\021\024\016\027\017\016 \ \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034\033 )Tj 0.131 Tw T* (\r\t\023\024\035\027\036\027\017\016 \022\024\027\021\030\024\035\034\027\ \t\b \017\f\f\035\036\007\024\r\026\027\017\005, \004\021\024 \022\030\026\ \005\027\036 )Tj 0.187 Tw T* [(\026\021\030\031\007\027\017\021\036\035\034\027\024 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.327 0 Td [(\023\036\030\036\007\024\r\t\b )0.5(\233\204\233. )0.6(\212\026\027\027\t\005 )0.5(\023\024\007\b\024\007 )]TJ 0.257 Tw -8.327 -1.218 Td [(\016\r\035\016\036\021\f\016 \f\022\024\030\036\036 \017\f\022\035\033\004\ \036\027\017\036\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\002\013\036\023\030\017\027\026\027\027\t\b )Tj 0.052 Tw T* (\023\030\026\r\017\035 \b\017\030\031\030\020\017\004\036\f\022\024\020\024\ \035\036\004\036\027\017\016 \200\002\217\215\025. \215\030\017\n\036\027\ \036\027\017\036 )Tj 0.307 Tw 0 -1.218 TD (\220\027\007\024\r\017\007\036\024\b\017\030\031\030\020\017\004\036\f\022\ \017\b \021\036\b\027\024\035\024\020\017\005, \023\024\r\024\035\016\033\ \013\017\b )Tj 0.097 Tw 0 -1.218 TD (\023\030\024\r\036\f\021\017 \007\036\021\026\035\034\027\t\005 \024\f\n\ \024\021\030 \002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\n\026)Tj 0 Tw (-)Tj 0.078 Tw T* (\035\024\020\024 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\235\024\030\n\017\030\024\r\026\021\034 \007\017\r\036\030\f\017\024\027\ \027\031\033 \022\024\035\024\f\021\024\n\031, )Tj 0.197 Tw T* (\017\n\036\036\021 \002\036\031\f\035\024\r\027\t\036 \023\030\036\017\n\ \031\013\036\f\021\r\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027)Tj 0 Tw (-)Tj T* (\027\024\n \200\002\217\215\025 [34].)Tj 0.291 Tw T* (\221\030\026\027\f\035\033\n\017\027\026\035\034\027\024\036 \031\001\017\ \r\026\027\017\036 \030\026\027\t \023\030\016\n\024\005 \022\017\001\022\ \017, )Tj 0.36 Tw 0 -1.218 TD (\024\f\024\002\036\027\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024\r\t\b \233\204\233, \023\030\036\007\f\021\026\r\ \035\016\036\021 \f\024\002\024\005 )Tj 0.032 Tw 0 -1.218 TD [(\021\036\b\027\017\004\036\f\022\017 )0.6(\f\035\024\032\027\031\033 )0.5(\n\026\027\017\023\031\035\016\006\017\033 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.607 0 Td [(\r\t\t\r\026\036\021 )0.5(\024\023\030\036)]TJ 0 Tw (-)Tj 0.14 Tw -15.607 -1.218 Td (\007\036\035\036\027\027\t\036 \021\030\031\007\027\024\f\021\017 \007\026\ \032\036 \031)Tj /Span<>> BDC ( )Tj EMC (\024\023\t\021\027\t\b \f\023\036\006\017\026\035\017\f\021\024\r. )Tj 0.246 Tw 0 -1.218 TD (\025\030\024\n\036 \021\024\020\024, \004\021\024 \007\026\027\027\026\016\ \n\026\027\017\023\031\035\016\006\017\016 \f\023\024\f\024\002\f\021\r\ \031\036\021 )Tj 0.12 Tw T* (\007\024\023\024\035\027\017\021\036\035\034\027\024\005 \002\026\022\021\ \036\030\017\026\035\034\027\024\005 \022\024\027\021\026\n\017\027\026\006\ \017\017 \022\035\036\021)Tj 0 Tw (-)Tj 0.187 Tw T* (\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\r \021\ \026\026, \r\t\023\024\035\027\036\027\017\036 \036\036 \023\030\026\022\ \021\017)Tj 0 Tw (-)Tj 0.129 Tw T* (\004\036\f\022\017 \r\f\035\036\023\031\033, \022\026\022 \023\030\026\r\ \017\035\024, \027\036 \023\024\r\024\035\016\036\021 \007\024\002\017\021\ \034\f\016 )Tj 0.055 Tw T* (\022\026\004\036\f\021\r\036\027\027\024\005 \026\007\026\023\021\026\006\ \017\017 \f\035\024\036\r \f\021\036\027\022\017 \022\017\001\022\017. \210\ \007\027\017\n )Tj 0.069 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\027\021\024\r \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \021\026\022\021\017\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022)Tj 0 Tw (-)Tj -0.016 Tw T* (\021\017\r\027\t\b \200\002\217\215\025 \016\r\035\016\036\021\f\016 \024\ \021\022\026 \024\021 \031\001\017\r\026\027\017\016 \030\026\027\t \022\ \017\001)Tj 0 Tw (-)Tj 0.13 Tw T* (\022\017. \207\024\020\026\021\024\036 \022\030\024\r\024\f\027\026\002\032\ \036\027\017\036 \023\030\016\n\024\005 \022\017\001\022\017 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.229 Tw T* (\022\035\033\004\036\027\027\024\n \023\026\f\f\026\032\036 \021\024\035\ \f\021\024\022\017\001\036\004\027\024\020\024 \f\024\007\036\030\032\017\ \n\024\020\024 )Tj 0.216 Tw T* (\004\036\030\036 \024\027\031 \200\002\217\215\025 \023\024\r\024\035\ \016\036\021 \007\024\002\017\021\034\f\016 \026\032\017\r\035\036\027\017\ \016 )Tj 0.086 Tw T* [(\007\036\235\036\022\021\026 )0.5(\n\036\027\036\036 )0.5(\274 \036\036 )0.5(\024\022\030\031\032\027\024\f\021\017 )0.5([1,5]. \221\026\022 )0.5(\032\036 \024\021\n\036)]TJ 0 Tw (-)Tj 0.198 Tw T* (\004\026\033\021\f\016 \030\026\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \f\021\026\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b )Tj -0.004 Tw T* (\030\036\f\023\024\027\007\036\027\021\024\r, \023\030\036\007\023\024\004\ \017\021\026\033\013\017\b \031\001\017\r\026\021\034 \007\036\235\036\022\ \021 \023\030\016)Tj 0 Tw (-)Tj 0.134 Tw T* (\n\024\005 \022\017\001\022\017 \(t \022\030\017\021\036\030\017\005 \222\ \021\034\033\007\036\027\021\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.134 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\). \204\036\027\036\036 )Tj 0.033 Tw T* [(\024\023\t\021\027\t\036 )0.5(\b\017\030\031\030\020\017 \004\026\013\036 )0.5(\023\030\036\007\023\024\004\017\021\026\033\021 )0.5(\027\036 \031\001\017\r\026\021\034 )0.5(\027\036)]TJ 0 Tw (-)Tj T* (\007\036\f\021\030\031\022\021\017\r\027\t\036 \200\002\217\215\025.)Tj 0.286 Tw T* (\233\035\036\n\036\027\021\024\n \025\024\027\006\036\023\006\017\017, \023\ \024\r\024\035\016\033\013\017\n \f\027\017\017\021\034 \022\024\027)Tj 0 Tw (-)Tj 0.445 Tw T* (\021\026\n\017\027\026\006\017\033 \022\035\036\021\004\026\021\024\004\027\ \t\b \023\030\024\f\021\030\026\027\f\021\r \021\026\026 \004\036\030\036\  )Tj 0.086 Tw T* (\030\026\027\031 \023\030\016\n\024\005 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\n\036\027\034\001\017\021\034 \r\036\030\024\016\ \021\027\024\f\021\034 )Tj 0.417 Tw T* (\030\026\r\017\021\017\016 \017\027\235\036\022\006\017\024\027\027\t\b\ \024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025, )Tj 0.152 Tw T* (\016\r\035\016\036\021\f\016 \007\017\f\021\026\035\034\027\024\036 \024\ \021\n\t\r\026\027\017\036 \024\021\022\035\033\004\036\027\027\024\005 \ \004\026\f\021\017 )Tj -0.008 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \211\204\215 \017\n\036\033\021\f\016 \f\021\ \026\021\017\f\021\017)Tj 0 Tw (-)Tj 0.039 Tw T* (\004\036\f\022\017 \027\026\004\017\n\t\036 \030\026\035\017\004\017\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \f\023\024\f\024\002\026 \024\021\n\t\r\026)Tj 0 Tw (-)Tj -0.009 Tw T* (\027\017\016 \023\030\016\n\024\005 \022\017\001\022\017 \(\022\030\017\021\ \036\030\017\005 \215\017\030\f\024\027\026 \245)Tj 0 Tw 5.83 0 0 5.83 237.1827 265.3958 Tm (2)Tj 10 0 0 10 240.0977 262.0658 Tm (, )Tj /T1_1 1 Tf 0.409 0 Td (p)Tj /T1_0 1 Tf -0.009 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0001\). )Tj 0.307 Tw -17.333 -1.218 Td (\203\026\002\035\033\007\026\036\n\026\016 \020\036\021\036\030\024\020\036\ \027\027\024\f\021\034 \f\024\024\021\027\024\001\036\027\017\016 \r\t\002\ \024\030\026 )Tj 0.145 Tw T* (\f\023\024\f\024\002\026 \024\021\n\t\r\026\027\017\016 \n\036\032\007\031\ \211\204\215 \027\036 \016\r\035\016\036\021\f\016 \f\021\026\021\017\f\ )Tj 0 Tw (-)Tj 0.127 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\024\005 \(\022\030\017\021\ \036\030\017\005 \025\030\026\n\036\030\026 V)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34, \f\035\026)Tj 0 Tw (-)Tj 0.191 Tw T* (\002\024\005 \f\017\035\t\). \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \211\204\215 \027\026\004\017\n\024 \030\ \026\035\017\004\026\033\021\f\016 )Tj -0.025 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \024\021\n\t\r\026\027\017\016 \023\030\016\n\ \024\005 \022\017\001\022\017 \004\036\030\036 \f\021\024\n\031 \(\026\027\ )Tj 0 Tw (-)Tj 0.105 Tw T* (\021\036\020\030\026\007\027\024\) \f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\036\024\002\035\026\007\026\027\017\036\n \027\026\ )Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 \(\022\030\017\021\036\030\017\005 )Tj -0.004 Tw T* (\215\017\030\f\024\027\026 \245)Tj 0 Tw 5.83 0 0 5.83 113.9657 180.1498 Tm (2)Tj 10 0 0 10 116.8807 176.8198 Tm (, )Tj /T1_1 1 Tf 0.414 0 Td (p)Tj /T1_0 1 Tf -0.004 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \). \203\026)Tj /Span<>> BDC ( )Tj EMC (4 )Tj 0.206 Tw -5.015 -1.218 Td (\211\204\215 \030\036\f\023\024\027\007\036\027\021\t \024\021\007\026\033\ \021 \023\030\036\007\023\024\004\021\036\027\017\036 \030\036\021\030\024\ \020\030\026\007)Tj 0 Tw (-)Tj -0.041 Tw T* [(\027\024\n\031 )0.5(\024\021\n\t\r\026\027\017\033 )0.6(\024\021\022\035\033\004\036\027\027\024\020\024 )0.6(\024\021\007\036\035\026 )0.5(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )]TJ 0 Tw T* (\(\004\036\030\036 \026\027\026\035\034\027\t\005 \022\026\027\026\035\)\ \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.414 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \007\017\f\022\031\f\f\017\024\027\027\t\ \b \026\f\023\036\022\021\024\r \024\002)Tj 0 Tw (-)Tj 0.282 Tw T* [(\f\031\032\007\026\036\n\024\005 \023\030\024\002\035\036\n\t \016\r\035\ \016\036\021\f\016 )0.5(\027\036\024\002\b\024\007\017\n\024\f\021\034 \r\t)]TJ 0 Tw (-)Tj 0.52 Tw T* (\023\024\035\027\036\027\017\016 \021\026\022\024\005 \021\030\026\r\n\026\ \021\017\004\027\024\005 \n\026\027\017\023\031\035\016\006\017\017, \022\ \026\022 )Tj 0.308 Tw T* (\030\031\021\017\027\027\024\036 \023\026\030\026\030\036\022\021\026\035\ \034\027\024\036 \017\035\017 \023\030\036\f\026\022\030\026\035\034\027\ \024\036 \007\030\036)Tj 0 Tw (-)Tj 0.229 Tw T* (\027\017\030\024\r\026\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 [35\22637]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\n\036\033\021\f\016 )Tj 0.193 Tw 23.244 64.543 Td (\f\024\024\002\013\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\004\026\f\021\031\033 \027\036\026\007\036\022)Tj 0 Tw (-)Tj 0.067 Tw 0 -1.218 TD (\r\026\021\027\024\n \017\f\023\024\035\027\036\027\017\017 \007\026\027\ \027\024\005 \n\026\027\017\023\031\035\016\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\t\b \233\204\233 [38\22640].)Tj 0.062 Tw 0 -1.218 TD (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \007\035\016 15 \030\036\f\023\024\027\007\036\027\021\024\r \024\ \030\017)Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\036\027\021\017\030\026\n\017 \031\f\021\026\027\024\r\022\017 \023\026\ \030\026\030\036\022\021\026\035\034\027\t\b \007\030\036\027\026\032\036\ \005 \016\r)Tj 0 Tw (-)Tj 0.298 Tw 0 -1.218 TD (\035\016\035\017\f\034 \f\036\007\026\035\017\013\027\t\036 \002\031\020\ \030\t, \r\t\f\024\021\026 \023\026\035\034\006\026 \017\035\017 \032\036\ )Tj 0.258 Tw 0 -1.218 TD (\020\035\031\002\017\027\026 \031\f\021\026\027\024\r\022\017 \n\036\027\ \036\036 7 \f\n. \211\022\026\026\027\027\t\005 \023\024\007\b\024\007 \ )Tj 0.317 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\036 \007\030\036\027\026\032\036\005, \r\036\ \030\024\016\021\027\036\036 \r\f\036\020\024, \027\036 \002\031\007\036\ \021 )Tj 0.073 Tw T* (\024\002\036\f)Tj /Span<>> BDC ( )Tj EMC 1.91 0 Td (\023\036\004\017\r\026\021\034 \007\024\035\032\027\024\005 \007\030\036\ \027\026\032\027\024\005 \235\031\027\022\006\017\017, \004\021\024, \027\ \036)Tj 0 Tw (-)Tj 0.071 Tw -1.91 -1.218 Td (\f\024\n\027\036\027\027\024, \016\r\035\016\036\021\f\016 \023\030\036\007\ \017\022\021\024\030\024\n \030\026\r\017\021\017\016 \024\f\035\024\032\ \027\036)Tj 0 Tw (-)Tj 0.039 Tw T* (\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \022\035\036\021\004\026\021\024\004\027\t\b \ \023\030\024\f\021\030\026\027\f\021\r \021\026\026, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024)Tj 0 Tw (-)Tj 0.444 Tw T* (\002\036\027\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\017\b \030\026\027\036\027\017\016\b )0.5(\r\027\036\002\030\033\001\017\027\027\024\020\024 )]TJ 0 Tw T* (\024\021\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017 \(\217\ \017\f.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.438 Tw T* [(\202\027\026\035\017 \030\036\031\035\034\021\026\021\024\r )0.5(\026\027\022\036\021\017\030\024\r\026\027\017\016 \r\t\016\r\017\035 \026\ \002\f\024)]TJ 0 Tw (-)Tj 0.268 Tw T* [(\035\033\021\027\031\033 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\023\024\007\b\024\007\024\r )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 15.835 0 Td [(\r\t\002\024\030\031 )0.5(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.483 Tw -15.835 -1.218 Td [(\007\024\r\026\021\036\035\034\027\024\f\021\017 )0.6(\r\t\023\024\035\027\036\027\017\016 )0.6(\220\035\036\n\036\027\021\024\r )0.5(\025\024\027\006\036\023\006\017\017 )]TJ 0.036 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.242 0 Td [(\r\f\036\b )0.5(\211\204\215. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 6.306 0 Td [(\220\021\024\n )0.5(49 )0.5(\030\036\f\023\024\027\007\036\027\021\024\r )0.6(\024\f\031\013\036\f\021\r\035\016)]TJ 0 Tw (-)Tj 0.287 Tw -7.549 -1.218 Td (\033\021 \023\026\030\026\030\036\022\021\026\035\034\027\024\036 \007\030\ \036\027\017\030\024\r\026\027\017\036 \023\024\f\035\036 \031\001\017\r\ \026\027\017\016 )Tj 0.135 Tw T* (\035\026\023\026\030\024\021\024\n\027\024\005 \030\026\027\t, \004\021\024\ \027\036 \023\024\r\024\035\016\036\021 \024\f\031\013\036\f\021\r\035\ \016\021\034 )Tj -0.021 Tw T* (\022\024\027\021\030\024\035\034 \031\f\021\026\027\024\r\022\017 \007\030\ \036\027\026\032\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\031\f\035\024\r\035\017\r\026\036\021 \r\t\f\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\022\017\036 \030\017\f\022\017 \023\024\r\030\036\032\007\036\027\017\016\ \032\017\027\036\027\027\024 \r\026\032\027\t\b \026\027\026\021\024\n\ \017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017\b \f\021\030\031\022\021\031\030 \021\026\026 \(\217\ \017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.316 Tw T* (\211\004\017\021\t\r\026\016 \r\t\f\024\022\031\033 \021\030\026\r\n\026\ \021\017\004\027\024\f\021\034 \023\026\030\026\030\036\022\021\026\035\034\ \027\024)Tj 0 Tw (-)Tj 0.257 Tw T* (\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\024\n\036\ \032\027\024\f\021\027\t\n \007\024\f\021\031\023\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.108 Tw T* [(\032\036 )0.5(\030\017\f\022\017 )0.6(\016\021\030\024\020\036\027\027\024\020\024 )0.5(\023\024\r\030\036\032\007\036\027\017\016 )0.5(\024\030\020\026\027\024\r )0.6(\n\026\035\024\020\024 )]TJ 0.118 Tw T* (\021\026\026, \007\026\027\027\026\016 \n\026\027\017\023\031\035\016\006\ \017\016, 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0 0 1 k /GS1 gs /T1_1 1 Tf ( \205\200\027\026\020\023\022\007\027\024\n\031\027 \022\016\031\240\032\ \020\255\027\025\022\027 \b\f\r\240\022\025\013 \240\022\f\020\023\027)Tj 0 Tw (-)Tj 0 -1.2 TD (\032\020\f\017\025\031\235 \r\024\023\020\025\031\021\n\022 \033\020\032\ \020\032\027\n\023\020\f\017\025\013\200 \030\032\027\025\020\255\027\235\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.041 Tw T* [(F)-16(igure 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Schematic rep)46(resentation of)]TJ /Span<>> BDC ( )Tj EMC [(the dep)13(th of)]TJ /Span<>> BDC ( )Tj EMC (the bilateral )Tj 0 Tw T* (installation of)Tj /Span<>> BDC ( )Tj EMC (pararectal drains)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td 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$n'y+A2tVg1R'ؐ;6]F~W_'=e(`-huƝ/D >y'[QEQEPҪEQEQEQE!0䗎l \gv$bE[!*QEQE’`)*wk( dd^"<6/')<Q.Ȑ-;Q}z((ӪEQEQEQEk۱#8:&GI.p["7 x-z̶z7!!#W((+Y\3iӶGv|Ƌ^PY` $~-΂seiU #y+qks:=@Ӫ- }QEժEQEQEQE&xu|FϩMQEQEQXQ6M1{(Ot5\&_^r\^J; GFMU`J0EE U6jKݏO2+!D%i( (s44eI׉O*yʐSSjݙs)yn1Ds Υm ḧz˹ݬR,m!Ai>EE|+i@B[STRq]W JVGU.ܴ/DsrP=xF{vkgviM!4m`8S%;Koh`S-uJĐmMUy!ج՗քgp;2 "袊ЪEQEQEQJ(ޕjv-Dp87v6H~նP2aN8}iCuhEQERΦ֌Z[~h]!G^ݑo&r7C4):@G@FNq(NVׅ 8]ZYhAmpg)i%K;= tuzXjn1+&Qµvg"\Fk֍A>=zZSqoh(ꮷ#U9N,%L}h@rAp0f[BP)JFAKL3->* =A;h#)ڮw{%4̋*Kpj(}Y )ӕYn|sA\)<{ m{LQEQI4.\f?ʣdOiNQEѪEQEQERԎY#ѓuKpHPϫٚHsceɳ7in\s'[I=((%J 2I4qMI-v=9;2`!zN4VdMtzcY;vFz=\QEQ^;Ů5"/) 8P*kp"Lͼl[C;(Q;3gLɅ-u(79(*GX; |:n> e_u5cs'ljmqiuK#e&hjm d'7vBCe1ջgOzLZ[}2[0zFz]jybO ߋ\%{\^ $osW4QErlqcNdUq$9MΆ~ni uPҪEQEQEWW2|t 7G(x'vEQE0}imT)$IKmZiW"P.#SΎ'Sm̥'D$^(((xIrhԶZfC%D6QHA M0ɅH$ea{yJ{!"S2D4PKYyV Q}۲[(3!JO–?65ݖcR^%cKiZ{ԇ=ΓNxv3.ZKBTc(yA(+Lvv+-XJIҖ?s/Btt%3QEӪEQEQEQEQEQH'뢬vՎ'wrAe$H#7ieRi (((5/Z^JۀfXH ,B;ȯN'R[S@|4za%=꭭s>4"b)2MLGBqi#g '^IJn^۶œy׈?q=j l+,\qHV9G{Ǡj;Q;%Ӝ-uom-QBJHfmSm%1nXgMwQERu~dxAfsYi^;SPԪEQEQEQEQERLoFW.Rs:@#}}L$S of;-2d%(%ƽQEQEQEQ]RGȒe8pRN)fv[.qt 9=!Jbʆp{xv(Z(((((jsXBl+ poigp (dE#<,,)znTUnݣ{Niy֐-$)*x WQE&:hIJe7.OyWe9Q@תEQEQEQEQEfjn2㨶n!.Hczjv|ۋYB[m ` ((((+:fȵG1|J7~B=MՏ$6杼kҮ.:ӸM iq6Zq%+m`)  ƷqeYf;*K]v)ZhWh+'R èyZL %҄`mz]ЪEQEQEQEQEQEQEQEQEQEQKzKuSW{C)yΎy>3_gVzwLkn6fkќ7qǼoZ(((ѪEQEQEQEQEQEQEQEQEQEQEa]%ohK&4qLks#xm gwAlM?-!gf-?:ꎚr((ҪEQEQEQEQEQEQEQEQEQEQEڠޠo6eܤ$ioJ=v\/%O3vV7xуъp(( endstream endobj 941 0 obj <>stream User endstream endobj 855 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.17 Tw 10 0 0 10 42.5197 724.8299 Tm (\022\026\027\026\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\007\ \036\035\026 \023\030\016\n\024\005 \022\017\001\022\017. )Tj 0.036 Tw 0 -1.218 TD (\215\030\017\n\036\027\036\027\017\036 \032\036 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\017\b \n\036\021\024\007\017\022 \(\030\017\020\017\ \007\027\026\016 )Tj -0.02 Tw T* (\023\030\024\022\021\024\f\022\024\023\017\016, \235\017\002\030\024\022\ \024\035\024\027\024\f\022\024\023\017\016\), \027\036\f\n\024\021\030\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.514 Tw T* (\f\024\022\031\033 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(\030\036\027\021\020\036\027\024\035\024\020\017\004\036\f\022\017\036 \n\ \036\021\024\007\017\022\017 \(\030\036\027\021\020\036\027\024\020\030\026\ \235\017\016 )Tj 0.09 Tw T* [(\002\030\033\001\027\024\005 )0.6(\023\024\035\024\f\021\017, )0.5(\006\017\f\021\024\031\030\036\021\030\024\020\030\026\n\n\026, )0.5(\r\031\035\034\027\036\030\024\020\030\026)]TJ 0 Tw (-)Tj T* (\235\017\016, \022\024\027\021\030\026\f\021\027\026\016 \023\030\024\022\ \021\024\020\030\026\235\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007.\) [10,11].)Tj -0.052 Tw T* (\200\027\031\021\030\017\023\030\024\f\r\036\021\027\t\036 \n\036\021\024\ \007\t \007\017\026\020\027\024\f\021\017\022\017 \023\024\r\030\036\032\ \007\036\027\017\005 )Tj -0.002 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017 \(\023\030\024\022\021\024-,\ \030\036\022\021\024-, \235\017\002\030\024\022\024\035\024\027\024\f\022\ \024\023\017\016\) )Tj -0.055 Tw 0 -1.218 TD (\023\030\017\n\036\027\016\033\021 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(\f\035\024\032\027\024\005 \n\036\007\017\022\024-)Tj 0.03 Tw T* (\021\026\022\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\ \036, \b\026\030\026\022\021\036\030\027\024\005 \007\035\016 \023\036\030\ \036\007\024\r\t\b )Tj 0.215 Tw T* (\220\021\026\023\024\r. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\024\021\031 \017\f\023\024\035\027\036\027\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024)Tj 0 Tw (-)Tj 0.22 Tw T* [(\022\031\033 \007\017\026\020\027\024\f\021\017\004\036\f\022\031\033 )0.5(\006\036\027\027\024\f\021\034, \026\027\024\f\022\024\023\017\016 \030\036\ \f\023\024\027)]TJ 0 Tw (-)Tj 0.154 Tw T* (\007\036\027\021\026\n\017 \017\f\023\024\035\034\031\036\021\f\016 \022\ \030\026\005\027\036 \030\036\007\022\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\017 )Tj -0.033 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\036\007\024\r\t\b \233\204\233. \207\024\035\036\036 )0.5(\004\026\f\021\024\036 \023\030\017\n\036\027\036\027\017\036 )0.5(\007\026\027\027\024\020\024 )]TJ 0.083 Tw T* (\n\036\021\024\007\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215, \r\036\030\024\016\021\027\024, \023\024\r\024\035\017\021\ \027\026\004\017\021\036\035\034)Tj 0 Tw (-)Tj 0.06 Tw T* (\027\024 \f\027\017\017\021\034 \004\026\f\021\024\021\031 \023\024\007\ \027\036\005 \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\ \025, \004\021\024, )Tj 0.216 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \031\n\036\027\034\001\017\021\ \022\024\035\017\004\036\f\021\r\024 \024\f\035\024\032\027\036\027\017\ \005 )Tj 0 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \022\026\021\036\020\024\030\017\017 \023\024\f\021\030\ \026\007\026\r\001\017\b.)Tj 0.124 Tw T* (\217\036\f\023\024\027\007\036\027\021\t \021\026\022\032\036 \024\021\n\ \036\004\026\033\021, \004\021\024 \021\026\022\017\036 \n\036\021\024\007\ \t \022\026\022 )Tj 0.09 Tw T* (\030\036\027\021\020\036\027\024\020\030\026\235\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026\r\031\022\024\r\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036 \n\026)Tj 0 Tw (-)Tj 0.098 Tw T* (\035\024\220\235\235\036\022\021\017\r\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \200\002\217\215\025, \021\026\ \022 \022\026\022 \023\024\r\024)Tj 0 Tw (-)Tj -0.043 Tw T* [(\035\016\033\021 )0.5(\026\023\024\007\024\030\017\021\034 )0.5(\023\024\r\030\036\032\007\036\027\017\036 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.5(\021\024\035\034\022\024 )]TJ 0.023 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\r\036\027\027\t\n \023\030\017\027\026\022\026\n. \215\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\007\017\027 \030\036\f\023\024\027\007\036\027\021 )Tj 0.298 Tw T* (\024\002\030\026\021\017\035 \r\027\017\n\026\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034 \017\f\023\024\035\034\024\r\026\027\ \017\016 )Tj 0.436 Tw T* [(\n\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\024\005 )0.6(\021\024\n\024\020\030\026\235\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.99 0 Td (\007\017\026\020\027\024\f\021\017\022\036 )Tj 0.105 Tw -16.99 -1.218 Td [(\200\002\217\215\025, )0.5(\022\024\021\024\030\026\016 )0.6(\024\020\030\026\027\017\004\036\027\026, )0.5(\022\026\022 )0.5(\017\r\036\f\021\027\024, )0.6(\027\026\035\017\004\017\036\n )]TJ 0.033 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \023\024\f\021\030\026\007\026\r\001\036\020\024 \ \235\036\030\030\024\n\026\020\027\017\021\027\t\b \017\027\024\030\024\007\ \027\t\b )Tj 0 Tw T* (\021\036\035.)Tj 0.413 Tw T* (\203\026\017\002\024\035\036\036 \031\007\024\002\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n \n\036\021\024\007\ \024\n )Tj 0.271 Tw T* (\007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\025, \024\f\024\ \002\036\027\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\b \(\r\036\030\b)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\036- \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\ \007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017\) \030\026)Tj 0 Tw (-)Tj 0.095 Tw T* (\027\036\027\017\016\b, \016\r\035\016\036\021\f\016 \022\024\n\023\034\033\ \021\036\030\027\026\016 \021\024\n\024\020\030\026\235\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0.202 Tw T* [(\024\021\f\031\021\f\021\r\017\016 )0.6(\027\036\024\002\b\024\007\017\n\024\f\021\017 )0.5(\f\023\036\006\017\026\035\034\027\024\005 )0.6(\023\024\007\020\024\021\024\r\022\017 )]TJ 0.049 Tw T* (\023\026\006\017\036\027\021\026, \f\022\024\030\024\f\021\017 \r\t\023\024\ \035\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \030\036\031\035\034\021\026\021\026 )Tj 0.164 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \(\r \021\024\n \004\017\f\035\ \036 \007\017\f\021\026\027\006\017\024\027\027\024\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.118 Tw T* (\r\024\n\024\032\027\024\f\021\017 \007\017\026\020\027\024\f\021\017\022\ \017 \f\024\004\036\021\026\027\027\t\b \023\024\r\030\036\032\007\036\027\ \017\005 )Tj 0.206 Tw T* ([12\22615]. \210\f\024\002\036\027\027\024 \r\t\f\024\022\024\005 \004\031\ \r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 \(\007\024 )Tj 0.14 Tw T* (97%\) \024\002\035\026\007\026\036\021 \022\024\n\002\017\027\026\006\017\ \016 \030\017\020\017\007\027\024\005 \023\030\024\022\021\024\f\022\024\ \023\017\017 )Tj 0.084 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\ \235\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \025\221)Tj /Span<>> BDC ( )Tj EMC (\227 \017\030\030\017\020\024)Tj 0 Tw (-)Tj 0.243 Tw T* (\020\030\026\235\017\016 [9]. \210\007\027\026\022\024 \024\f\027\024\r\027\ \t\036 \n\036\021\024\007\t \007\017\026\020\027\024\f\021\017\022\017 )Tj 0.445 Tw T* [(\200\002\217\215\025, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\r\017\007\031 )0.5(\f\r\024\017\b )0.5(\021\036\b\027\017\004\036\f\022\017\b )0.5(\024\f\024\002\036\027\027\024\f\021\036\005, )]TJ 0.102 Tw T* (\021\030\031\007\027\024\007\024\f\021\031\023\027\t \007\035\016 \023\030\ \017\n\036\027\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024\r\t\b \233\204\233, )Tj 0.039 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \007\017\027\026\n\017\004\027\024 \017\n\036\ \027\016\033\013\036\005\f\016 )Tj 0.247 Tw T* (\n\036\007\017\022\024-\021\026\022\021\017\004\036\f\022\024\005 \024\002\ \f\021\026\027\024\r\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \036\f\035\017 )Tj 0.33 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (2 \211\204\215 \024\f\027\024\r\027\t\n \n\036\021\024\007\024\n \007\017\ \026\020\027\024\f\021\017\022\017 \200\002\217\215\025 )Tj 0.435 Tw 23.244 64.543 Td (\016\r\035\016\036\021\f\016 \023\026\035\034\006\036\r\024\036 \030\036\ \022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036\ , \021\024 )Tj 0.184 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\b \031\030\024\r\027\016\b \024\021\ \n\036\004\026\036\021\f\016 \026\022\024\027\024\n\036\030\027\024\036\ )Tj 0.088 Tw T* (\007\024\n\017\027\017\030\024\r\026\027\017\036 \022\024\n\023\034\033\021\ \036\030\027\024\005 \021\024\n\024\020\030\026\235\017\017 \027\026\007\ \007\030\031)Tj 0 Tw (-)Tj T* (\020\017\n\017 \n\036\021\024\007\026\n\017 \017\f\f\035\036\007\024\r\026\ \027\017\016.)Tj 0.302 Tw T* (\210\023\030\036\007\036\035\036\027\027\t\036 \021\030\031\007\027\024\f\ \021\017 \023\030\036\007\f\021\026\r\035\016\036\021 \r\t\002\024\030 \021\ \026\022)Tj 0 Tw (-)Tj 0.231 Tw T* (\021\017\022\017 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036\027\017\016 \022\026\022 \027\036\007\036\f\021\030\031\022\ \021\017\r\027\t\b )Tj 0.366 Tw 0 -1.218 TD (\(\n\036\027\036\036 \274 \024\022\030\031\032\027\024\f\021\017 \022\017\ \001\022\017\), \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.228 Tw 0 -1.218 TD (\027\t\b \200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \233\204\233 \r\027\036 \026\r\017\f\017\n\ \024\f\021\017 \024\021 )Tj 0.216 Tw T* (\211\204\215. \215\030\036\007\035\024\032\036\027\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (1971 \020\024\007\031 4D)Tj /Span<>> BDC ( )Tj EMC (\227 \022\024\027\006\036\023\006\017\016 )Tj 0.014 Tw T* (\(\025\024\027\006\036\023\006\017\016\), \f\024\f\021\024\016\013\026\016\ \017)Tj /Span<>> BDC ( )Tj EMC [(4 \220\035\036\n\036\027\021\024\r \(di)-15.9(ver)-10(sion)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj T* [(\024\021\r\036\007\036\027\017\036, debr)-37(idement)]TJ /Span<>> BDC ( )Tj EMC (\227 \b\017\030\031\030\020\017\004\036\f\022\026\016 \024\002\030\026\002\ \024\021\022\026, )Tj -0.021 Tw T* [(dr)-33(aina)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(\227 \007\030\036\027\017\030\024\r\026\027\017\036, dist)15(al w)-12(ashout)]TJ /Span<>> BDC ( )Tj EMC (\227 \007\017\f\021\026\035\034)Tj 0 Tw (-)Tj 0.041 Tw 0 -1.218 TD (\027\024\036 \024\021\n\t\r\026\027\017\036\) \f\021\026\035\026 \024\f\027\ \024\r\024\005 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD (\027\017\016 \030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\t\ \n \023\024\r\030\036\032\007\036\027\017\036\n )Tj 0.309 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017 [16]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \r\024\024\030\031\032\036\027\027\t\b\ )Tj 0.118 Tw T* (\022\024\027\235\035\017\022\021\026\b \007\026\027\027\024\005 \025\024\ \027\006\036\023\006\017\017 \023\030\017\007\036\030\032\017\r\026\036\021\ \f\016 \022\026\022 )Tj 0.115 Tw T* (\024\021\036\004\036\f\021\r\036\027\027\026\016, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026\030\031\002\036\032\027\026\016 \r\024\036\027\027\026\016 \n\036\007\ \017\006\017\027\026 )Tj 0.081 Tw T* ([2,17\22620]. \210\007\027\026\022\024 \030\016\007 \017\f\f\035\036\007\ \024\r\026\021\036\035\036\005 \024\021\n\036\004\026\033\021 \027\036)Tj 0 Tw (-)Tj 0.223 Tw T* [(\024\002\b\024\007\017\n\024\f\021\034 )0.5(\r\t\002\024\030\026 \002\024\035\036\036 \017\002\017\030\026\021\036\035\ \034\027\024\020\024, )0.5(\023\036\030\f\024)]TJ 0 Tw (-)Tj 0.481 Tw T* (\027\017\235\017\006\017\030\024\r\026\027\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\017\017\030\024\r\026\027\027\024\020\024 \023\024\007\ \b\024\007\026 )Tj 0.321 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 1.014 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\n\031 )0.6(\035\036\004\036\027\017\033 )0.6(\200\002\217\215\025, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.829 0 Td (\024\f\024\002\036\027\027\024\f\021\017 )Tj 0.329 Tw -16.843 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \024\020\030\026\027\017\004\036\027\017\016 \ \030\036\f\031\030\f\024\r, \007\036\235\017\006\017\021\026 \r\030\036)Tj 0 Tw (-)Tj 0.236 Tw T* (\n\036\027\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\036\007\024\f\021\026\021\024\004\027\024\020\024\ \024\023\t\021\026 \f\023\036\006\017\026\035\017\f\021\024\r )Tj 0.071 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \211\204\215 [21\22625]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\023\030\036\007\036\035\036\027\027\031\033 )Tj 0.024 Tw T* (\022\030\017\021\017\022\031 \r\t\t\r\026\036\021 \023\030\026\022\021\017\ \004\036\f\022\017 \022\026\032\007\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\n\036\027\021\024\r )Tj -0.008 Tw T* (\025\024\027\006\036\023\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\006\017\016 \220\022\f\023\036\030\021\024\r \r\026\030\034\ \017\030\031\036\021 \024\021 \023\024\035\027\024)Tj 0 Tw (-)Tj 0.129 Tw T* (\020\024 \024\021\022\026\026 \024\021 \027\036\022\024\021\024\030\t\b\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\016\026\021\036\035\034\027\024\020\024 \017\b )Tj 0.216 Tw T* (\017\f\023\024\035\027\036\027\017\016, \035\017\002\024 \023\030\017\n\036\ \027\036\027\017\016 \017\r\036\f\021\027\t\b \023\024\007\b\024\007\024\ \r )Tj 0.113 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\027\024\n \r\026\030\ \017\026\027\021\036, \027\026\023\030\017\n\036\030, \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.144 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\016 \022\024\035\024\f\021\024\n\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017-\007\024\f\021\031\023\026 \017\035\017 \r\t)Tj 0 Tw (-)Tj T* (\023\024\035\027\036\027\017\016 \007\017\r\031\035\034\f\017\017 \026\027\ \026\035\034\027\024\020\024 \032\024\n\026 [20,26\22630].)Tj -0.028 Tw T* [(\215\030\024\r\036\007\036\027\027\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\024 )0.6(\r\t)]TJ 0 Tw (-)Tj 0.276 Tw T* (\f\024\022\031\033 \023\030\017\r\036\030\032\036\027\027\024\f\021\034 \ \030\036\f\023\024\027\007\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\016\026\021\036\035\034)Tj 0 Tw (-)Tj 0.408 Tw T* (\027\024\n\031 \024\021\022\035\033\004\036\027\017\033 \023\024\r\030\036\ \032\007\036\027\027\024\020\024 \031\004\026\f\021\022\026 \022\017\001\ \022\017, )Tj 0.017 Tw T* [(\024\007\027\026\022\024 )0.5(17/75 )0.5(\024\023\030\024\001\036\027\027\t\b )0.6(\017\035\017 )0.5(23 )0.5(\(14; )0.6(34\))]TJ /Span<>> BDC ( )Tj EMC 17.779 0 Td [(% )0.5(\f\004\017\021\026\033\021 )]TJ 0.242 Tw -17.779 -1.218 Td [(\r\024\n\024\032\027\t\n \017\f\022\035\033\004\017\021\034 )0.5(\r\t\023\024\035\027\036\027\017\036 \002\026\017\f\027\024\020\024 \220\ \035\036)]TJ 0 Tw (-)Tj 0.263 Tw T* (\n\036\027\021\026 \025\024\027\006\036\023\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \235\024\030\n\017\030\024\r\026\027\017\036 \007\017\r\036\030\f\017\ \024\027\027\024\005 )Tj 0.078 Tw T* (\022\017\001\036\004\027\024\005 \f\021\024\n\t. \203\036\024\002\b\024\007\ \017\n\024\f\021\034 \024\021\022\035\033\004\036\027\017\016 \023\026\f\ \f\026)Tj 0 Tw (-)Tj 0.155 Tw T* [(\032\026 )0.5(\022\017\001\036\004\027\024\020\024 )0.6(\f\024\007\036\030\032\017\n\024\020\024 )0.5(\027\036 )0.5(\r\t\t\r\026\036\021 )0.6(\f\024\n\027\036\027\017\016, )]TJ 0.087 Tw T* (\023\030\017\004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b \200\002\217\215\025\ \023\030\036\007\023\024\004\021\017\021\036\035\034)Tj 0 Tw (-)Tj 0.421 Tw T* (\027\t\n \030\036\001\036\027\017\036\n \016\r\035\016\036\021\f\016 \235\ \024\030\n\017\030\024\r\026\027\017\036 \023\036\021\035\036\r\024\005 \ )Tj 0.074 Tw T* [(\007\r\031\f\021\r\024\035\034\027\024\005 \022\024\035\024\f\021\024\n\t\ , )0.5(\004\021\024 \027\026\004\017\021\036\035\034\027\024 )0.5(\024\002\035\036\020\004\026\036\021 )]TJ 0.212 Tw T* (\021\036\004\036\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\020\024 \023\036\030\017\024\007\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024)Tj 0 Tw (-)Tj 1.771 Tw T* [(\f\035\036\007\031\033\013\017\036 )0.6(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024-\r\024\f\f\021\026\ \027\024\r\017\021\036\035\034\027\t\036 )]TJ 0.169 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\026. )0.5(\221\026\022\032\036, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b )0.5(\200\002\217\215\025 )]TJ 0.73 Tw T* (\007\024\023\031\f\021\017\n\024 \235\024\030\n\017\030\024\r\026\027\017\ \036 \023\036\021\035\036\r\024\005 \f\017\020\n\024\f\021\024\n\t )Tj 0.337 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017-\007\024\f\021\031\023\026, \004\021\024 \023\024\021\036\ \027\006\017\026\035\034\027\024 \n\024\032\036\021 \027\026\004\017)Tj 0 Tw (-)Tj 0.361 Tw T* (\021\036\035\034\027\024 \031\f\022\024\030\017\021\034 \023\030\024\006\ \036\f\f \r\024\f\f\021\026\027\024\r\035\036\027\017\016 \030\026\027\036\ \027\024)Tj 0 Tw (-)Tj 0.207 Tw T* (\020\024. \203\036\031\021\036\001\017\021\036\035\034\027\026\016 \f\021\ \026\021\017\f\021\017\022\026 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b )Tj 0.165 Tw T* (\024\f\035\024\032\027\036\027\017\005 \021\026\022\024\020\024 \007\024\ \f\021\031\023\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\r\024\n\024\032\027\024\f\021\034 \026\007\036\022)Tj 0 Tw (-)Tj 0.206 Tw T* (\r\026\021\027\024\005 \030\036\r\017\017\017 \002\030\033\001\027\024\005\ \023\024\035\024\f\021\017 \027\026\004\017\021\036\035\034\027\024 \f\ \024)Tj 0 Tw (-)Tj 0.186 Tw T* (\022\030\026\013\026\036\021 \036\020\024 \022\026\032\031\013\017\036\f\ \016 \023\030\036\017\n\031\013\036\f\021\r\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj -0.034 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\036\027\027\t\n\017 \024\f\022\024\035\024\004\ \027\t\n\017 \030\026\027\036\027\017\016\n\017 [31\22633]. )Tj 0.671 Tw T* [(\200\026\032\027\t\n )0.6(\031\f\035\024\r\017\036\n )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 )0.6(\007\017\r\036\030\f\017\024\027\027\024\005 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_2 1 Tf 25 0 0 25 503.8146 56.0378 Tm (111)Tj ET endstream endobj 757 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 758 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 759 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 760 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 761 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 950 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.045 Tw 10 0 0 10 70.8661 383.8459 Tm (\017\035\017 13 \(7; 23\) % \030\036\f\023\024\027\007\036\027\021\024\r\ \026\030\020\031\n\036\027\021\017\030\024\r\026\035\017 \r\t)Tj 0 Tw (-)Tj 0.046 Tw 0 -1.218 TD (\023\024\035\027\036\027\017\036 \007\026\027\027\024\020\024 \220\035\036\ \n\036\027\021\026 \025\024\027\006\036\023\006\017\017 \030\036\026\035\ \017\026\006\017\036\005 )Tj 0.105 Tw T* (\021\030\036\002\024\r\026\027\017\005 \030\036\020\035\026\n\036\027\021\ \017\030\031\033\013\017\b \007\024\022\031\n\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026)Tj 0 Tw (-)Tj T* (\027\017\005 \f\021\026\030\001\036\020\024 \n\036\007\017\006\017\027\f\ \022\024\020\024 \027\026\004\026\035\034\027\017\022\026.)Tj /T1_1 1 Tf 0.126 Tw 0 -2.436 TD [(\026\002\212\006\002\217 )0.5(\2369:)]TJ /T1_0 1 Tf [( \253\200\t\023\024\035\027\016\036\021\036 )0.5(\035\017 \200\t )0.5(\007\017\r\031\035\034\f\017\033 )0.5(\f\235\017\027\022)]TJ 0 Tw (-)Tj 0 -1.218 TD (\021\036\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017\ \023\030\016\n\024\005 \022\017\001\022\017?\273)Tj 0.716 Tw 23.244 7.307 Td (\025\024\035\017\004\036\f\021\r\024 \030\036\f\023\024\027\007\036\027\021\ \024\r, \023\030\036\007\023\024\004\017\021\026\033\013\017\b \r\t)Tj 0 Tw (-)Tj 0.141 Tw T* [(\023\024\035\027\036\027\017\036 )0.6(\007\017\r\031\035\034\f\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.364 0 Td [(\017\f\f\035\036\007\031\036\n\t\b )0.6(\211\204\215 )0.5(\f\021\026\021\017\f\021\017)]TJ 0 Tw (-)Tj 0.184 Tw -10.364 -1.218 Td (\004\036\f\022\017 \027\026\004\017\n\024 \027\036 \030\026\035\017\004\ \026\035\017\f\034 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\ \026\226)Tj 0 Tw T* (\205\030\017\n\026\027\026\226\216\024\035\021\024\027\026, )Tj /T1_2 1 Tf 8.247 0 Td (p)Tj /T1_0 1 Tf 0.301 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,15\). \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 )Tj 0.024 Tw -8.247 -1.218 Td (\007\017\r\031\035\034\f\017\016 \026\027\026\035\034\027\024\020\024 \f\ \235\017\027\022\021\036\030\026 \027\036 \016\r\035\016\036\021\f\016 \220\ \035\036\n\036\027)Tj 0 Tw (-)Tj 0.11 Tw T* (\021\024\n \025\024\027\006\036\023\006\017\017, \022\024\035\017\004\036\ \f\021\r\024 \030\036\f\023\024\027\007\036\027\021\024\r, \r\t\023\024\035\ \027\016)Tj 0 Tw (-)Tj 0.035 Tw T* (\033\013\017\b \036\036, \r)Tj /Span<>> BDC ( )Tj EMC (1,5 \(0,8; 2,8\) \030\026\026 \002\024\035\034\001\036, \004\036\n \f\004\ \017\021\026\033\013\017\b )Tj 0.387 Tw T* (\007\026\027\027\031\033 \n\026\027\017\023\031\035\016\006\017\033 \027\ \036\024\002\016\026\021\036\035\034\027\024\005 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (10\). )Tj 0.173 Tw T* [(\200\t\023\024\035\027\036\027\017\036 )0.5(\007\026\027\027\024\005 \n\026\027\017\023\031\035\016\006\017\017 )0.5(\017\035\017 )0.5(\024\021\022\026 \024\021 )0.5(\027\036\036 )]TJ 0.235 Tw T* (\027\036 \026\r\017\f\036\035 \024\021 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \f\021\026\032\026 \030\036\f\023\024\027\007\036\027\ \021\024\r )Tj 0.389 Tw T* (\(t-\022\030\017\021\036\030\017\005 \222\021\034\033\007\036\027\021\026\ , )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.389 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,77; \024\007\027\024\235\026\022\021\024\030\027\t\005 )Tj /T1_2 1 Tf -0.053 Tc 0.053 Tw T* [(AN)-33(O)-37(V)-11(A)]TJ /T1_0 1 Tf 0 Tc 0 Tw 2.533 0 Td (, )Tj /T1_2 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 213.3539 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.149 Tw 10 0 0 10 303.3071 188.9979 Tm (\215\030\017 \200\002\217\215\025 \007\017\026\020\027\024\f\021\017\004\ \036\f\022\017\005 \026\035\020\024\030\017\021\n \n\024\032\036\021 \r\022\ \035\033)Tj 0 Tw (-)Tj 0.392 Tw T* (\004\026\021\034 \022\026\022 \235\017\017\022\026\035\034\027\t\036 \n\ \036\021\024\007\t \017\f\f\035\036\007\024\r\026\027\017\016, \021\026\022\ )Tj -0.021 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\036 \017\027\f\021\030\031\n\036\027\021\026\ \035\034\027\t\036 \n\036\021\024\007\017\022\017. \215\026\035\034\006\036\ \r\024\036 )Tj 0.401 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 \023\030\016\n\024\005 \022\017\ \001\022\017 \016\r\035\016\036\021\f\016 \f\026\n\024\005 \007\024)Tj 0 Tw (-)Tj 0.314 Tw T* [(\f\021\031\023\027\024\005 )0.6(\n\036\021\024\007\017\022\024\005, )0.5(\027\024 )0.5(\017\n\036\033\013\036\005 )0.5(\027\017\022\031\033 )0.6(\004\031\r\f\021\r\017)]TJ 0 Tw (-)Tj 0.204 Tw T* (\021\036\035\034\027\024\f\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \031\030\024\r\027\036\n \035\024\032\027\024\024\021\ \030\017\006\026\021\036\035\034\027\t\b )Tj 0.115 Tw T* (\030\036\031\035\034\021\026\021\024\r [8]. \200\026\032\027\031\033 \030\ \024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \200\002\217\215\025 )Tj 0.362 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \024\020\030\026\027\017\004\036\027\027\t\b \ \030\036\f\031\030\f\024\r \n\024\032\036\021 \017\020\030\026\021\034 )Tj 0.436 Tw T* (\026\027\024\f\022\024\023\017\016, \023\024\r\024\035\016\033\013\026\016\ \r\t\016\r\017\021\034 \027\026\035\017\004\017\036 \022\030\024\r\017 \ )Tj 0.169 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024\r\030\036\032\007\036\027\017\036 \026\027\ \026\035\034\027\024\020\024 )Tj ET q 70.866 178.639 221.102 108.456 re W n q /GS0 gs 221.1023475 0 0 108.5106011 70.8661504 178.5853609 cm /Im0 Do Q Q BT /T1_2 1 Tf 0.021 Tw 8 0 0 8 70.8661 169.0394 Tm (\004\032\022\026\027\007\020\025\022\027: \(1\) 4120; \(2\) 1230; \(3\) \ 1234; \(4\) 1240; \(5\) 1243; \(6\) )Tj 0.152 Tw 0 -1.2 TD (1324; \(7\) 1342; \(8\) 1423; \(9\) 1432; \(10\) 3120; \(11\) 3124; \(12\ \) )Tj 0 Tw T* (3412; \(13\) 0 \(\025\027 \030\032\027\025\022\032\r\005\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.469 Tw 9 0 0 9 70.8661 133.3701 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \021\020\032\022\020\ \025\023\031\021 \033\031\024\f\027\030\031\021\020\023\027\f\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\025\031\024\023\022 \030\032\027\025\022\032\031\021\020\025\022\t \004\ \202 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \204\023\020\033\020\200 )Tj 0 Tw T* (\204\021\020\n\r\020\006\022\022. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.228 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Distr)-37(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the seq)14(uence of)]TJ /Span<>> BDC ( )Tj EMC (pararectal tissue )Tj 0.063 Tw T* [(drainag)12.1(e )0.5(op)13(tions )0.5(in )0.6(e)-15(xtraper)-36.9(itoneal )0.5(rectal )0.6(w)12(ounds )0.6(at )0.5(dif)-40(ferent )]TJ 0 Tw T* [(stag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(ev)16.1(acuation. A)14.1(t dif)-39.9(ferent stag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(ev)16.1(acuation. )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 9.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \032\027\024\033\031\ \025\030\027\025\023\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\030\031\021\020\023\027\f\017\025\031\024\023\022 \021\ \013\033\031\f\025\027\025\022\t \030\032\027\025\022\032\031\021\020\025\ \022\t \022)Tj /Span<>> BDC ( )Tj EMC (\r\213\022\021\020\025\022\t \032\020\025\013)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 9.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.299 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-1.9(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(n)-0.6(t)-32.9(s a)-9.1(c)2.3(c)2.8(o)-3(r)-3(d)-3(i)3.9(n)-0.6(g t)-2.9(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e s)0.5(e)-9.4(q)-3(u)-3.1(e)-7(n)-2.9(c)2.8(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(d)0.8(r)3.4(a)-6.3(i)3.9(na)-5.2(g)-6.8(e a)-5.1(n)-4.8(d w)2.3(o)-3.4(u)0.6(n)-4.8(d s)6.7(u)-4.8(t)-1.1(u)1.6(r)-39(i)4(n)-0.6(g)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8662 715.181 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 295.0532 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 340.4075 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 385.7618 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 431.1161 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6595 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8662 694.1118 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 694.1118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 295.0532 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.4075 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 385.7618 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 431.1161 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 694.1118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6595 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8662 682.6425 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 671.1813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 682.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 682.6425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 659.97 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 671.1813 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 246.8642 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 671.1813 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 659.72 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 648.2587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 659.72 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 659.72 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 637.0474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 648.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 246.8642 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 648.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 636.7974 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 636.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 636.7974 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 625.3361 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 625.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 625.3361 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 613.8748 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 613.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 613.8748 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 602.4136 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 602.4136 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 295.0532 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 602.4136 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 91.8389 706.5464 Tm (\200\002\217\f\r\240\002\004\003\r\f\001\b\002\217\003\001 \240\006\r\b\ \t\006\002\004\b\t\r)Tj /Span<>> BDC ( )Tj EMC (\237 )Tj 4.948 -1.2 Td (\210\230\t\004\b\t\r \006\004\b\013)Tj 15.463 0.6 Td (\255\t\214\002\f\013)Tj 5.637 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj 6.81 0 Td (\026\217\r\n\002)Tj -52.102 -2.034 Td (\017\206\233\r\214 \013\206\002\006\220\t)Tj /T1_4 1 Tf 24.313 0.001 Td (N)Tj /T1_1 1 Tf 5.603 -0.001 Td (22)Tj 5.669 0 Td (20)Tj 5.669 0 Td (18)Tj 5.947 0 Td (8)Tj 5.568 0 Td (68)Tj /T1_0 1 Tf -52.771 -1.433 Td (\212\030\036\027\017\030\024\r\026\027\017\036 \026\021\036\n \031\001\017\ \r\026\027\017\036)Tj /T1_2 1 Tf 24.376 0 Td (n)Tj /T1_0 1 Tf 5.846 0 Td (6)Tj 5.669 0 Td (5)Tj 5.669 0 Td (7)Tj 5.669 0 Td (1)Tj 5.596 0 Td (19)Tj /T1_2 1 Tf -29.224 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.611 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(11; 50\))Tj 5.919 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(6; 46\))Tj 5.419 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(17; 64\))Tj 5.919 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(0; 53\))Tj 5.596 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(17; 39\))Tj -51.068 -1.433 Td (\211\001\017\r\026\027\017\036 \026\021\036\n \007\030\036\027\017\030\024\ \r\026\027\017\036)Tj /T1_2 1 Tf 24.34 0 Td (N)Tj /T1_0 1 Tf 5.632 0 Td (16)Tj 5.669 0 Td (15)Tj 5.669 0 Td (11)Tj 5.919 0 Td (7)Tj 5.596 0 Td (49)Tj /T1_2 1 Tf -29.224 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.611 0 Td (73)Tj /Span<>> BDC ( )Tj EMC (\(50; 89\))Tj 5.669 0 Td (79)Tj /Span<>> BDC ( )Tj EMC (\(54; 94\))Tj 5.669 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(36; 83\))Tj 5.669 0 Td (87)Tj /Span<>> BDC ( )Tj EMC (\(47; 99\))Tj 5.846 0 Td (73)Tj /Span<>> BDC ( )Tj EMC (\(61; 83\))Tj /T1_2 1 Tf -51.068 -1.433 Td (p)Tj /T1_0 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 24.387 0 Td (p)Tj /T1_0 1 Tf 13.747 0 Td (0,59)Tj -38.134 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_2 1 Tf (V)Tj /T1_0 1 Tf ( \025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 24.386 0 Td (V)Tj /T1_0 1 Tf 11.244 0 Td (0,18\(-0,07; 0,39\))Tj -35.631 -1.433 Td (\231\026\027\f\t)Tj /T1_2 1 Tf 22.987 0 Td (f)Tj /T1_0 1 Tf (/\(1)Tj /Span<>> BDC ( )Tj EMC (\244 f\))Tj 27.804 0 Td (2,7)Tj /Span<>> BDC ( )Tj EMC (\(1,6; 4,6\))Tj /T1_2 1 Tf 7 0 0 7 70.8661 590.929 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ T* (\032\020\024\033\032\027\030\027\f\027\025\022\t.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 563.225 Tm (\020\004\206\f\t\204\004 10.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\031\f\t \032\027\024\033\031\025\030\027\025\023\031\021, \021\013\ \033\031\f\025\t\005\212\022\200 \030\022\021\r\f\017\024\022\005 \024\203\ \022\025\n\023\027\032\020 \033\032\t\026\031\235 \n\022\213\n\022 \033\032\ \022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-5(0)-29.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.863 0 Td [( T)-6.4(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(p)-2.7(r)-2(o)-5.3(p)-9.1(o)-3(r)-41.9(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(nt)-32.9(s p)-11.3(e)-6(r)-32.9(f)-13.4(o)-3(r)-18.6(m)1.4(i)3.9(n)-0.6(g a)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-10.9(c)-32.4(t)-2(a)-4.4(l s)4.4(p)-1.1(h)1.7(i)3.9(n)-2.9(c)-32.4(t)-1.6(e)-6(r c)2.9(o)-4(nv)-2.5(u)-1.6(l)-32.4(s)-12.5(i)-1.4(o)-4(n d)0.8(u)1.6(r)-38.9(i)3.9(n)-0.6(g f)-13.4(o)-3(r e)-32.3(x)-32.6(t)-9.5(r)3.3(a)-5.2(p)-11.3(e)-6(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.4(l r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.8(s)]TJ ET /GS2 gs q 1 0 0 1 70.8661 547.9231 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 292.2185 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9272 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 473.6358 547.9231 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 526.8539 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 428.2815 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 473.6358 526.8539 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 515.3846 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 503.9234 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 515.3846 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 492.7121 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 503.9234 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 246.8642 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 503.9234 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 492.4621 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 481.0008 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 492.4621 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 469.7895 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 481.0008 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 246.8642 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 481.0008 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 469.5395 cm 0 0 m 175.998 0 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1 428.2815 458.0782 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 473.6358 458.0782 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 446.8669 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 446.8669 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 446.6169 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 473.6358 446.6169 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 435.1557 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 473.6358 435.1557 cm 0 0 m 51.274 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 83.599 539.2885 Tm (\026\013\212\002\f\b\r\b\t\r \240\t\210\f\001\217\t\t \217\226\t\b\220\003\ \r\006\004 \212\006\235\214\002\005 )Tj 7.985 -1.2 Td (\220\t\230\220\t)Tj 13.278 0.6 Td (\255\t\214\002\f\013)Tj 5.46 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj 6.988 0 Td (\026\217\r\n\002)Tj -51.925 -2.034 Td (\017\206\233\r\214\013 \013\206\002\006\002\220)Tj /T1_4 1 Tf 24.136 0.001 Td (N)Tj /T1_1 1 Tf 5.426 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj 5.746 0 Td (75)Tj /T1_0 1 Tf -52.594 -1.433 Td (\212\026, \r\t\023\024\035\027\016\033)Tj /T1_2 1 Tf 24.199 0 Td (n)Tj /T1_0 1 Tf 5.419 0 Td (16)Tj 5.919 0 Td (8)Tj 5.419 0 Td (16)Tj 5.919 0 Td 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VeE2Rd+c  uRnU;l-Uו I%ZC܏&YIM95(Efcn\T۳F"! Tel{_T T4:rL'\Mi=d, lyKmy RsNOļռkFUM)dxdŴhI|"$E)9ȉ`x8\:Ɠ:Sf;G1NXD';ݮY=iN҈he%h7@׵@t.$ +EHl[)y0QuwkUt&-fbۇ\J&c6Y2󧴁|/:{H"%H%2ᛅ1ɍ$V-bzOHQMC'kBcge9-yվBɗ= [,yAR%Y[(hi=lZI)fusꊧ$$zJ&̫qn*b\J3cy|/:{HY2󧴂"]i'qHgo][,y@վBɗ=Ou Ze2nF$г}BS֜ǍlOPORIA/ɮ-uo96QWK|/:{HY2󧴂"7u*MLR3=}!dΞL UQ֙v̮!@iRTI"T̺X I|/:{HY2󧴂%U\qp]jP>9;(%վBɗ= [,yAUHdY-ȷuMj]&# R]igD:\5&(oeOiV &^txfQIZ.O$Ibٍ#p-I3g9Eh_":enkuȞi'!dΞ T23uס f4%xM9'yTJ2^b(m:ui4-$ſ|/:{HY2󧴂i*5~=6aCӅ\K:zJO0* Vd*y|ִOnZ7z[,yAՔPk)9VS1&۞؃Ԍ(Hq/&>* pqQoľM5o׸Vgl[9-վBɗ= [,yAESff˳De UJ.t@Y2󧴁|/:{H8TȉrThԤXc"1е@ڕ7"]MߎLsz919]i{LX15PuG'GHЕ9֤q)#%Vf6LC)j͆Xr2"%jKm5ZI*)JQRDX9I2R%ʐ댼˓WJ4-1Xc14++nP7J]i!o $ȎQֆb py֘iodIj j$=co%j;fVjXIQn Ȓi07[^(ufF*TF=<=4څ7>=iO Lcx۪)R%fy2eG5bESp0Ʀ%lݕ#ARhёUTC$3W%(fU#TRdE⟅BL֓IM03Ze5(*AMi&Dg1эp L *!MgZ9m["{C$1R`"O:&F^NSAҵ@ӵ@ endstream endobj 952 0 obj <>stream endstream endobj 948 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.258 Tw 10 0 0 10 42.5197 493.4479 Tm (\026\002\212\006\002\217 \2367:)Tj /T1_2 1 Tf ( \253\211\022\026\032\017\021\036 \023\024\f\035\036\007\024\r\026\021\036\ \035\034\027\024\f\021\034 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.107 Tw 0 -1.218 TD [(\027\036\027\017\016 )0.6(\220\021\026\023\024\r )0.5(\024\023\036\030\026\021\017\r\027\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.306 0 Td (\r\027\036)Tj 0 Tw (-)Tj 0.065 Tw -20.306 -1.218 Td (\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\ \016\n\024\005 \022\017\001\022\017: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \235\024\030\n\017\030\031\033 )Tj -0.004 Tw T* (\022\024\035\024\f\021\024\n\031; 2)Tj /Span<>> BDC ( )Tj EMC (\227 \031\001\017\r\026\033 \035\026\023\026\030\024\021\024\n\027\031\033\ \030\026\027\031; 3)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021)Tj 0 Tw (-)Tj 0.112 Tw T* (\n\t\r\026\033 \007\017\f\021\026\035\034\027\031\033 \004\026\f\021\034\ \022\017\001\022\017; 4)Tj /Span<>> BDC ( )Tj EMC (\227 \007\030\036\027\017\030\031\033 \023\026)Tj 0 Tw (-)Tj 0.052 Tw T* (\030\026\030\036\022\021\026\035\034\027\031\033 \022\035\036\021\004\026\ \021\022\031; 0)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036 \007\030\036\027\017\030\031\033 \023\026\030\026\030\036\022\ )Tj 0 Tw (-)Tj T* (\021\026\035\034\027\031\033 \022\035\036\021\004\026\021\022\031\273.)Tj 0.574 Tw T* (\222\030\026\r\027\036\027\017\036 \022\024\n\002\017\027\026\006\017\005\ \023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017 \007\ \030\036)Tj 0 Tw (-)Tj 0.473 Tw T* (\027\017\030\024\r\026\027\017\016 \023\026\030\026\030\036\022\021\026\035\ \034\027\024\005 \022\035\036\021\004\026\021\022\017 \f\021\026\021\017\ \f\021\017\004\036)Tj 0 Tw (-)Tj 0.254 Tw T* (\f\022\017 \027\026\004\017\n\024 \027\036 \030\026\035\017\004\026\035\ \f\016 \n\036\032\007\031 \211\204\215 \(\022\030\017\021\036\030\017\005\ )Tj 0 Tw T* (\205\017\001\036\030\026\226\205\030\017\n\026\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_3 1 Tf 11.821 0 Td (\032)Tj /T1_2 1 Tf 0.066 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,95\), )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\027\031\021)Tj 0 Tw (-)Tj 0.466 Tw -11.821 -1.218 Td [(\030\036\027\027\016\016 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\b\026\030\026\022\021\036\030\017\024\r\026\035\026\f\034 )0.6(\f\035\026\002\024\005 )]TJ 0.072 Tw 23.244 13.396 Td (\f\017\035\024\005 \f\r\016\017 \(\022\024\220\235\235\017\006\017\036\027\ \021 \f\024\023\030\016\032\036\027\027\024\f\021\017 \025\030\026\n\036\ \030\026, )Tj /T1_3 1 Tf 0 Tw T* (V)Tj /T1_2 1 Tf -0.022 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,33 \(0,11; 0,52\))Tj /Span<>> BDC ( )Tj EMC 8.053 0 Td (%. \203\026\017\002\024\035\036\036 \004\026\f\021\t\n\017 \022\024\n\002\ \017\027\026\006\017)Tj 0 Tw (-)Tj 0.076 Tw -8.053 -1.218 Td [(\016\n\017 )0.5(\016\r\035\016\035\017\f\034 )0.5(\2531-2-3-4\273 )0.6(\023\030\017\n\036\027\016\036\n\026\016 )0.5(25/75 )0.5(\030\036\f\023\024\027)]TJ 0 Tw (-)Tj 0.225 Tw T* (\007\036\027\021\026\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 33 \(22; 45\))Tj /Span<>> BDC ( )Tj EMC 10.414 0 Td (% \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\016 \2531-2-4-3\273 )Tj 0.381 Tw -10.414 -1.218 Td (\017\f\023\024\035\034\031\036\n\026\016 16/75 \b\017\030\031\030\020\026\ \n\017)Tj /Span<>> BDC ( )Tj EMC (\227 21 \(13; 32\))Tj /Span<>> BDC ( )Tj EMC 21.351 0 Td (% )Tj 0 Tw -21.351 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.394 Tw T* (\222\024\r\024\022\031\023\027\024\f\021\034 \r\026\030\017\026\027\021\024\ \r \023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\036\005\ \r\t)Tj 0 Tw (-)Tj 0.268 Tw T* [(\023\024\035\027\036\027\017\016 )0.6(\007\030\036\027\017\030\024\r\026\027\017\016 )0.5(\023\026\030\026\030\036\022\021\026\035\034\027\024\005 )0.6(\022\035\036\021\004\026\021\022\017 )]TJ 0.251 Tw T* (\030\026\007\036\035\017\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \022\035\033\004\036\r\t\036 \020\030\031\023\023\t: 1 \020\030\ \031\023\023\026 \023\024)Tj 0 Tw (-)Tj 0.132 Tw T* (\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\036\005, \020\007\ \036 \007\030\036\027\017\030\024\r\026\027\017\036 \023\030\036\007\001\ \036\f\021\r\031\036\021 )Tj 0.065 Tw T* (\031\001\017\r\026\027\017\033 \035\026\023\026\030\024\021\024\n\027\024\ \005 \030\026\027\t,)Tj /Span<>> BDC ( )Tj EMC (\227 49/68 \030\036\f\023\024\027\007\036\027)Tj 0 Tw (-)Tj 0.013 Tw T* [(\021\024\r )0.6(\017\035\017 )0.5(73 )0.6(\(61; )0.6(83\))]TJ /Span<>> BDC ( )Tj EMC 8.023 0 Td [(% )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 1.768 0 Td [(2 )0.6(\020\030\031\023\023\026, )0.6(\020\007\036 )0.5(\026\022\030\t\021\017\036 )0.6(\002\030\033\001)]TJ 0 Tw (-)Tj 0.131 Tw -9.791 -1.218 Td (\027\024\005 \023\024\035\024\f\021\017 \023\030\036\007\001\036\f\021\r\ \031\036\021 \007\030\036\027\017\030\024\r\026\027\017\033,)Tj /Span<>> BDC ( )Tj EMC (\227 19/68 )Tj 0.128 Tw T* (\017\035\017 27 \(17; 39\))Tj /Span<>> BDC ( )Tj EMC 6.771 0 Td (% \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (9\). \221\026\022\017\n \024\002\030\026\024\n, \022\024\n\002\017)Tj 0 Tw (-)Tj 0.017 Tw -6.771 -1.218 Td (\027\026\006\017\017 \023\024\f\035\036\007\024\r\026\021\036\035\034\027\ \024\f\021\036\005 \031\001\017\r\026\027\017\016 \035\026\023\026\030\024\ \021\024\n\027\024\005 )Tj 0.087 Tw T* (\030\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \023\036\030\017\027\036\026\035\ \034\027\t\n \007\030\036\027\017\030\024\r\026\027\017\036\n )Tj 0 Tw T* (\023\030\017\n\036\027\016\035\017\f\034 \004\026\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (2,7 \(1,6; 4,6\) \030\026.)Tj /T1_1 1 Tf 0.124 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2368: )Tj /T1_2 1 Tf (\253\025\026\022\026\016 \024\f\027\024\r\027\026\016 \006\036\035\034 \r\ \t\023\024\035\027\036\027\017\016 \030\031)Tj 0 Tw (-)Tj -0.013 Tw 0 -1.218 TD (\021\017\027\027\024\020\024 \023\026\030\026\030\036\022\021\026\035\034\ \027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033)Tj 0 Tw (-)Tj T* (\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\016\n\024\005\ \022\017\001\022\017?\273)Tj 0.326 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \006\036\035\017 )Tj -0.013 Tw T* (\007\030\036\027\017\030\024\r\026\027\017\016 \f\030\036\007\017 \030\036\ \f\023\024\027\007\036\027\021\024\r \017\f\f\035\036\007\031\036\n\t\b \ \211\204\215 )Tj 0.227 Tw T* (\027\036 \r\t\016\r\035\036\027\024 \(\022\030\017\021\036\030\017\005 \205\ \017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\024\ \027\026, )Tj /T1_3 1 Tf 0 Tw T* (\032)Tj /T1_2 1 Tf 0.22 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,23\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\027\031\021\030\036\027\027\016\016 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034 \b\026)Tj 0 Tw (-)Tj 0.382 Tw T* (\030\026\022\021\036\030\017\024\r\026\035\026\f\034 \f\035\026\002\024\ \005 \f\017\035\024\005 \f\r\016\017 \(\022\024\220\235\235\017\006\017\ )Tj 0 Tw (-)Tj 0.091 Tw T* (\036\027\021 \f\024\023\030\016\032\036\027\027\024\f\021\017 \025\030\026\ \n\036\030\026, )Tj /T1_3 1 Tf 0 Tw (V)Tj /T1_2 1 Tf 0.091 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,23 \(\2440,002; 0,43\). )Tj 0.216 Tw T* (\207\024\035\034\001\017\027\f\021\r\024 \024\023\030\024\001\036\027\027\ \t\b \f\023\036\006\017\026\035\017\f\021\024\r 53/75 \017\035\017 )Tj 0.147 Tw T* (70 \(59; 81\) % \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \211\204\215 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \030\031\021\017\027)Tj 0 Tw (-)Tj 0.167 Tw T* (\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\ \036\f\035\036\007\031\033\021 \006\036\035\034 \023\030\024\235\017\035\ \026\022\021\017\022\017 )Tj 0.349 Tw T* [(\017\027\235\036\022\006\017\024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\024\030\024\027\t \022\ \035\036\021\004\026\021\022\017 )]TJ 0.19 Tw T* (\021\026\026. \210\007\027\026\022\024 11/75 \017\035\017 15 \(7; 25\))Tj /Span<>> BDC ( )Tj EMC 15.183 0 Td (% \030\036\f\023\024\027\007\036\027\021\024\r )Tj -0.046 Tw -15.183 -1.218 Td (\030\026\f\f\004\017\021\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\031\033 \007\017\026\020\027\024\f\021\ \017\022\031 \017\027\235\036\022)Tj 0 Tw (-)Tj 0.074 Tw T* [(\006\017\024\027\027\t\b )0.6(\024\f\035\024\032\027\036\027\017\005 )0.5(\f\024 )0.5(\f\021\024\030\024\027\t )0.6(\022\035\036\021\004\026\021\024\004\027\t\b )0.6(\023\030\024)]TJ 0 Tw (-)Tj -0.038 Tw T* (\f\021\030\026\027\f\021\r \021\026\026 \023\031\021\036\n \030\031\021\ \017\027\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016,\ \026)Tj /Span<>> BDC ( )Tj EMC (10/75 )Tj ET q 42.52 218.239 221.102 126.508 re W n q /GS0 gs 221.1023475 0 0 126.5156782 42.5196833 218.2307037 cm /Im0 Do Q Q BT /T1_3 1 Tf 0.119 Tw 8 0 0 8 42.5197 208.6394 Tm (\004\032\022\026\027\007\020\025\022\027: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \253\016\020\024\027\007\n\022\273 \025\020)Tj /Span<>> BDC ( )Tj EMC (\030\032\027\025\020\255\020\200, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \r\032\031\021\027\025\017 \030\027\203\027\n\023\020 )Tj 0.072 Tw 0 -1.2 TD (\n\022\213\n\022, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \025\020)Tj /Span<>> BDC ( )Tj EMC (2 \024\026 \b\f\r\240\255\027 \030\027\203\027\n\023\020 \n\022\213\n\022\ , 4)Tj /Span<>> BDC ( )Tj EMC (\227 \021\013\024\031\023\020 \033\020\f\017\006\020, )Tj -0.036 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\227 2\2314)Tj /Span<>> BDC ( )Tj EMC (\024\026 \b\f\r\240\255\027 \023\020\016\031\021\031\235 \030\022\020\203\ \032\020\b\026\013, 6)Tj /Span<>> BDC ( )Tj EMC (\227 \n)Tj /Span<>> BDC ( )Tj EMC (\023\020\016\031\021\031\235 \030\022\020\203\032\020\b\026\027, )Tj 0.017 Tw T* (\f\027\021\020\023\031\032\020\026, 7)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031)Tj /Span<>> BDC ( )Tj EMC (\023\020\016\031\021\031\235 \240\032\005\213\022\025\013, 8)Tj /Span<>> BDC ( )Tj EMC (\227 \016\020)Tj /Span<>> BDC ( )Tj EMC (\024\027\030\020\f\022\212\025\013\027 \240\r\b\032\013, )Tj 0.14 Tw T* (9)Tj /Span<>> BDC ( )Tj EMC 0.873 0 Td [(\227 )0.5(\031\032\022\027\025\023\022\032\r\005\024\017 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 9.111 0 Td [(\032\027\016\r\f\017\023\020\023\013 )0.6(\n\031\026\033\017\005\023\027\032\025\031\235 )0.5(\023\031\026\031\b\032\020\203\022\022, )]TJ 0 Tw -9.984 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\227 \016\020\023\032\r\030\025\t\005\024\017 \031\023\021\027\023\022\023\ \017, 11)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027 \030\032\027\025\022\032\r\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.235 Tw 9 0 0 9 42.5197 144.1701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\022\020\b\032\020\026\026\020 \032\020\024\033\032\027\030\027\f\027\ \025\022\t \030\031\f\027\235 \021\013\240\031\032\020 \032\027)Tj 0 Tw (-)Tj -0.029 Tw T* (\024\033\031\025\030\027\025\023\020\026\022 \031\032\022\027\025\023\022\ \032\020 \030\f\t \n\031\025\023\032\031\f\t \b\f\r\240\022\025\013 \r\024\ \023\020\025\031\021\n\022 )Tj 0 Tw T* (\033\020\032\020\032\027\n\023\020\f\017\025\013\200 \030\032\027\025\020\ \255\027\235 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.036 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Diag)14(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the distr)-36.9(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(ropor)-40(tions of)]TJ /Span<>> BDC ( )Tj EMC (re)Tj 0 Tw (-)Tj -0.004 Tw T* [(spondents)33(\222 )0.5(choice of)]TJ /Span<>> BDC ( )Tj EMC 8.084 0 Td (a)Tj /Span<>> BDC ( )Tj EMC [(reference )0.5(point )0.5(for monitor)-36.9(ing the)]TJ /Span<>> BDC ( )Tj EMC [(dep)13(th )]TJ 0.21 Tw -8.084 -1.2 Td (of)Tj /Span<>> BDC ( )Tj EMC (installation of)Tj /Span<>> BDC ( )Tj EMC [(pararectal drains in e)-15(xtraper)-37(itoneal rectal )]TJ 0 Tw T* [(w)12(ounds)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.123 Tw 0 72.346 TD [(\020\004\206\f\t\204\004 )0.5(8.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(\216\f\r\240\022\025\020 )0.5(\r\024\023\020\025\031\021\n\022 )0.5(\033\020\032\020\032\027\n\023\020\f\017\025\013\200 )0.5(\030\032\027\025\020\255\027\235 )0.6(\032\027\024\033\031\025\030\027\025\023\020\026\022 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC 33.965 0 Td [(\211\240\206\004\202 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 4.367 0 Td [(\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 )0.5(\031\n\020\016\020\025\022\t )]TJ 0 Tw -38.332 -1.2 Td (\026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.163 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(8)-39.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.136 Tw 3.474 0 Td [( )0.5(T)-6.4(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC 2.116 0 Td [(d)-5.3(e)-7.7(p)-2.5(t)-10.6(h )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 3.794 0 Td [(i)3.9(n)3.7(s)-14.8(t)-2(a)-4.5(l)-3.8(l)-1.1(a)-9.2(t)-29.1(i)-1.4(o)-4(n )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 6.098 0 Td [(p)-6.3(a)-4.2(r)3.3(a)-4.2(r)-1.9(e)-10.9(c)-32.4(t)-2(a)-4.5(l )0.5(d)0.8(r)3.3(a)-6.3(i)3.9(na)-5.2(g)-6.7(e )0.5(b)-2.4(y )0.5(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(n)-0.6(t)-32.9(s )0.6(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 15.823 0 Td [(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.2(e)-6(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l )0.5(r)-2(e)-10.9(c)-32.4(t)-1.9(a)-4.5(l )0.5(w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.8(s )0.5(a)-9.2(t )0.5(v)6.3(a)-4.1(r)-39(i)-1.4(o)-3.4(u)-4.4(s )0.5(le)-8.2(v)2.3(e)-6.1(l)-32.4(s )]TJ -0.003 Tc 0.003 Tw -31.306 -1.2 Td [(o)1(f)]TJ /Span<>> BDC 0.792 0 Td ( )Tj EMC [(m)-8.3(e)-15.9(d)-6(i)-4.8(ca)-7.5(l)-2.9( ca)-7.2(r)-5(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.5809 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 207.1791 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 255.3681 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 693.5809 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 682.1117 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 207.1791 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 255.3681 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 682.1117 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 670.6425 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 659.1812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 670.6425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 647.9699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 659.1812 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 659.1812 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 659.1812 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 659.1812 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 659.1812 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 659.1812 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 647.7199 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 636.2587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 647.7199 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 625.0474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 636.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 636.2587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 636.2587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 636.2587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 636.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 636.2587 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 624.7974 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 613.3361 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 624.7974 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 602.1248 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 613.3361 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 613.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 613.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 613.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 613.3361 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 613.3361 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 601.8748 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 590.4135 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 601.8748 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 579.2022 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 590.4135 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 590.4135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 590.4135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 590.4135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 590.4135 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 590.4135 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 578.9522 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 158.9902 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 578.9522 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 567.491 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 158.9902 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 207.1791 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 448.124 567.491 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 546.4297 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 158.9902 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 448.124 546.4297 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 49.4486 684.9464 Tm (\027\f\210\206\t\b\004 \210\217\003\004\b\002\220\t \240\006\r\b\004\202\ \r\005)Tj 14.725 0 Td (\255\t\214\002\f\013)Tj 5.814 0 Td (2 \210\006\002\r\b\001)Tj 6.024 0 Td (3 \210\006\002\r\b\001)Tj 6.024 0 Td (4 \210\006\002\r\b\001)Tj 6.024 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 7.953 0.001 Td (\t)Tj /T1_1 1 Tf 5.058 -0.001 Td (\026\217\r\n\002)Tj /T1_2 1 Tf -52.102 -1.433 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 16.873 0 Td (N)Tj /T1_1 1 Tf 5.78 -0.001 Td (17)Tj 6.024 0 Td (12)Tj 6.024 0 Td (14)Tj 6.302 0 Td (5)Tj 11.769 0 Td (48)Tj /T1_2 1 Tf -52.771 -1.433 Td (\212\024 7 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (5)Tj 6.024 0 Td (1)Tj 6.024 0 Td (1)Tj 6.024 0 Td (1)Tj 5.181 0 Td (0,64*)Tj 6.866 0 Td (8)Tj /T1_3 1 Tf -36.915 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 5.039 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(9; 60\))Tj 6.274 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(0; 44\))Tj 6.14 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(0;39\))Tj 5.657 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(0; 76\))Tj 12.047 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(7; 30\))Tj -51.318 -1.433 Td (8\22610 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (7)Tj 6.024 0 Td (4)Tj 6.024 0 Td (7)Tj 6.024 0 Td (3)Tj 5.181 0 Td (0,96*)Tj 6.616 0 Td (21)Tj /T1_3 1 Tf -36.665 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 4.789 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(16; 71\))Tj 6.274 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(8; 69\))Tj 5.89 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(20;80\))Tj 5.907 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(11; 96\))Tj 12.047 0 Td (44)Tj /Span<>> BDC ( )Tj EMC (\(29; 59\))Tj -51.068 -1.433 Td (11\22615 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (5)Tj 6.024 0 Td (5)Tj 6.024 0 Td (5)Tj 6.024 0 Td (1)Tj 5.181 0 Td (0,94*)Tj 6.616 0 Td (16)Tj /T1_3 1 Tf -36.665 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 5.039 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(9; 60\))Tj 5.89 0 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(13;76\))Tj 6.024 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(11;71\))Tj 6.274 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(0;76\))Tj 11.681 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(20; 48\))Tj -51.068 -1.433 Td (\207\024\035\036\036 15 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (0)Tj 6.024 0 Td (2)Tj 6.024 0 Td (1)Tj 6.024 0 Td (0)Tj 5.181 0 Td (0,63*)Tj 6.866 0 Td (3)Tj /T1_3 1 Tf -36.915 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 5.289 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.774 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(2; 56\))Tj 6.274 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(0; 39\))Tj 6.024 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 58\))Tj 12.047 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(1; 17\))Tj /T1_3 1 Tf -51.568 -1.433 Td (p)Tj /T1_2 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_3 1 Tf 16.946 0 Td (p)Tj /T1_2 1 Tf 14.456 0 Td (0,63)Tj -31.402 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_3 1 Tf (V)Tj /T1_2 1 Tf ( )Tj 0 -1.2 TD (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_3 1 Tf 16.946 1.2 Td (V)Tj /T1_2 1 Tf 11.837 0 Td (0,23)Tj /Span<>> BDC ( )Tj EMC (\(-0,02; 0,48\))Tj /T1_3 1 Tf 7 0 0 7 42.52 534.945 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ 0 -1.2 TD (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (109)Tj ET endstream endobj 949 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   Y!13s4ASq"7QRTUa#$26BCbt %&'()*589:DEFGHIJVWXYZcdefghijruvwxyz?DAAAAAAAAAAAAAADAAYr|{rl<ѯv:3AG}"k).DגS]5MFbERh;:J{5G}"k).G5FbEReJi).DגS]$8L%"E4^IOtqw&My%=H<2LfEJkμMy%=HJ{NyEFd,'B;? gli 39mi 4-*X @h\uNBDU 4Wg ]PHqu_Wze&.Hu_V Rb =(j摎JXZADABt͙r1Z.NC6 * 68n&FgbɈ>\b\TdAE!Hh2JI: 4Ž fJv^"TBȉ 3I"ACRDm8dIQUQ6|15ቬ,诟 y=EA2=΂ΊttWφ&|1J!!ՊdѠ `ȫ z.΂ΊttWφ&|0v )EAh|0gAgE|bk: :+YY_><4FVt؝F|15ቬ,诟  ߉#h:*'z,诟 MgAgE|bk: :+QKEYk: :+YY_>΂Ί` ʌ+sd{ЍgAgE|bk: :+YY_>< QEntbz,诟 MgAgE|cITdž  P3hOk<΂ΊttWφ8\P"+|1႓ʍM5i<΂ΊttWφ8\R"+|1ၓʍM5i<΂ΊttWφ/@7"ƭ )0' zRլDAA_s], XH $jڭP&?#mQIJ<2xP2xPi*Kq*c5+ji4Rm;ye Z*e ZZcmJuklӐ*#'ʁ&cNiI$ATg,2xP2xPґcqŶiRDG{=)`yj G JVJȔGd[l6kYBLgY$EdHXXJ" >љ-%&\zJlI2Iġ<îÚU+Ԛ;M"5xum&2Ԩw**L&Dduʐ:Ma6):)5(Ft晏Rf+ X,7yf64^4Dd%X v NQKc:r (N9VNv^1Q8fnӷRtfP5"*r 4.X!" e몂DЫj @h Ja$A¸@dL A|a]c#H A'oSO`&'t$ہ NQsHi,-Z @$&.=JUY&dU Tt4RI.>lTH+qpa08YP+Xae ^_ɱ0<N5Tk[)qFUU-PVLR <$h6er;Mft:=ӇR34 jy#)DGs], XH >E'ȾBd<6,;[yd<L"qt"AF:HA'[Qy/>>E.:\L2y27gdg()FGD&$\FKURJ"H"m3٢JREX".F,JJJ:h;X rT#m+T#m+T^!G1ntMd66X!xFЯJJ;)NK~XNam***HI)FEmg狽B6Ҽ%B6Ҽ-0 d֕4mtrșDl*|(CPd%U5:mxJmxzvo%Y4N"V6SIr̮(g1k$N5 ćSRёwLFWFWFWeUg+PEB6Ҽ%B6Ҽ%B6Ҽ*V9Z**TV6d+'[QFWFW B*=WVii5UFIGe%=»dž)1rF@N;,0LOI!=(j摎JXZADA?&[;DjV4W]Djjs'U ɖ҅DVJISAdi^Zr:L&.5&IQITנ"'g)A M]%WfS@ 2:X;po a" .\XH[+m.P,I2A$ߑ$w'r 2pffM3M&i*(*@ OsRDT{H'"Y4UjFuG"!P%y\~Uvq'"*,Ң !v:[y ZxAG樂/)z' @Zv{ A" iU5+I*t;qn1ԒL\ʒ:, %rlS^Q(vV9XJq1&)X]Wަ<0I4vؕ9d bBM=tGW4vzRլDAe)6V88Ԛ5fDf'IW##<'ʢI;N4-FTd4L D@5&jZvT&iNqkbŀA⊊b ȸT4 kU1M5ndP09ĔZ骬uȓE2!ð+ 2U-$< >'./}5xAM?8\Z乽 Ue$fgfHzYh'Ś}imۉԣ2iZ\DmwoCSrp-AlDi=6d5Kө!r^H {E*g0 ʒyĚ]gb#*N͚׹/_NLzu"d5KөS)eIٮ{ \zu"d5Kө!r^Hb{pP󈩗bKa4עJN5Kө!r^H" dSQNN@J<(-^zb׹/_NLzu#a/Z՚RĶNMř<8dh[Ԙ5Kө!r^HD,<S>R+8Cɛ}q,Edh+jzu"d5KөV4CD3G>R=&&rg@q݅&8ڶ1hkܗR&C^}:%$%M؅ 4PTYIx&đ:=Ȅ<$TTsiX%ԉ׹/_N^Z$XCà4n zRլDAF5]E$u+"Ri*t#T sDk 6FFHu q4m #!eaKKM6U(BfC9ݮx}-2GK. ,$A2nlÜ(sAF||=՟/" n)6nH͔xL[]$Tʜݠ$TRIQ-'^- Pl-%H(NBoII6Zo(""4[5 JiQGȷ蔪$Zާ)x WGa#+s^~%v](zF*q˄b Қ7x́w B 0 :A]8zQG#'./}5xAM?8\:Dr6Sxd뙙""f(9%G%DLT{֫BPv) $Ag&RsrjJkJ2:K8$IMDax$,׍LgA&آtˆ{MQ+t{˃xK AL0=\v,,0  %IIU3;HYnWKSjAQ(Sr7>RYq-Ғ5Rh 'ӺDf:R['Im!JR\fyLf8B9 '6*NԑЕ(Rgm6ac%&QRM$gSACdI";4#b  #4!h:)4fdtҒy :$%F"Z3$'J{}9(zF*q˄b Ʊi)j1dT1!PuQ\:&vJeFTԒ(:3@:+@dž)1rN@NQsHi,-Z DAVNxIKЍɯDSKr-N ߋzJbXr) QmCCt a$vx)8*k/L2i5R=85唷GiTQ!Etl)3I5 /:8ACYiiw*H!ET%JNu唷G,8x_%O.6Q>yu唷G,8Ue=y6Kq45d(XS!$P8U(lL+&Xm,Ey3^YKtq[G~RmWHVJaBI?8yu唷G,8tz^F7 E:iY!IdP8&˩R%DddDVjw[DזRgrT{rl| s 񶴺UAJ"2bJ4gEY%J2JRE32"OTL4umTF(=S$NHn:> g8lmfi @)bSD崷Tt֧EIYVh&J񦲌$T2U6H7=|-CȰy-u,ðR*K3zfvT~*LJh5 W":H{e8"A@9j3&u4mqŦ KŴpNd7 4)RRԢ:+R=2rFGi,..&1jJV"5ң$1̍,+cKxىvmtfFF###Aꥉy\D< FPԥU*VR)"*Jɏ4+3+2y w(YIIc## kKi5)IGXU%Ή.X# BL͢nx-8G'?SHjȪʓ*pfI#R"O'Ω*Tbd826kQ_0vD+JL}P!A(RGMs*+X{qADAAiS.Ҥr2:F+m;eJP3'%$I"*sYDe*OzPTIa5k3*lX"-_n[Q/J104$mŲ5)u*:V (R{m-Z4I"5&Ɋ䘸4.J9Up..)嬢)JA%'Taqz즉-MIPD:&q 5jASEEvd;Q9%Fl q'YU+VĪLR/"C<%9'2i/ Qlԥ5SdosM咤o|U**IW"=*ѕ*F8f9XIrQ-IM4Tv)c,ɰJ{ 2"Q<<[XHEAֱH=TW%H[ɥB2m}D;5L 4nSQ{!Zw- X ^Z`u(p6j#:硚9JbXXUT#q)R#bq%WVPETZ NF)@ƦRL(%/6ΠÍIڪ De}e8e#4hmKIW*RdUuq:ښq$-&$c!VANr)n& BEN>stream endstream endobj 945 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.272 Tw 10 0 0 10 70.8661 493.4479 Tm (\200\t\002\024\030 \030\036\f\023\024\027\007\036\027\021\026\n\017 \024\ \030\017\036\027\021\017\030\024\r \007\035\016 \007\030\036\027\017\030\ \024\r\026)Tj 0 Tw (-)Tj 0.128 Tw 0 -1.218 TD (\027\017\016 \022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\ \021\030\026\027\f\021\r \021\026\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\031\036\n\t\b )Tj -0.012 Tw T* (\211\204\215 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 \027\036 \030\026\035\017\004\026\035\f\016 \(\022\030\017\021\ \036\030\017\005 )Tj 0 Tw T* (\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_1 1 Tf 11.982 0 Td (\032)Tj /T1_0 1 Tf 0.222 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,27\), \024\007\027\026\022\024 \r\027\031\021)Tj 0 Tw (-)Tj 0.24 Tw -11.982 -1.218 Td [(\030\036\027\027\016\016 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\r\t\002\024\030\022\017 )0.5(\b\026\030\026\022\021\036\030\017\024\r\026\035\026\f\034 )]TJ 0.123 Tw T* (\031\n\036\030\036\027\027\024\005 \f\017\035\024\005 \f\r\016\017 \(\022\ \024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\027\ \024)Tj 0 Tw (-)Tj 0.053 Tw T* (\f\021\017 \025\030\026\n\036\030\026, )Tj /T1_1 1 Tf 0 Tw (V)Tj /T1_0 1 Tf 0.053 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,55 \(0,21; 0,73\)\). \210\f\027\024\r\027\t\n \024\030\017\036\027)Tj 0 Tw (-)Tj 0.109 Tw T* (\021\017\030\024\n \007\035\016 \002\024\035\034\001\017\027\f\021\r\026\ \030\036\f\023\024\027\007\036\027\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024)Tj 0 Tw (-)Tj 0.049 Tw T* (\r\026\027\017\017 \022\035\036\021\004\026\021\024\004\027\t\b \023\030\ \024\f\021\030\026\027\f\021\r \021\026\026 \023\036\030\017\027\036\026\ \035\034\027\t\n )Tj 0.04 Tw T* (\007\024\f\021\031\023\024\n \016\r\035\016\035\026\f\034 \035\024\022\026\ \035\017\026\006\017\016 \030\026\027\t \f\021\036\027\022\017 \023\030\ \016\n\024\005 )Tj 0.256 Tw T* (\022\017\001\022\017, \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \031\f\021\026\027\026\r\035\017\r\026\035\017\ \f\034 \007\030\036\027\026\032\017 13/48 )Tj 0.267 Tw T* (\017\035\017 31 \(18; 47\))Tj /Span<>> BDC ( )Tj EMC 7.187 0 Td (% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\). \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\ \024 )Tj 0.017 Tw -7.187 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (1/48 \030\036\f\023\024\027\007\036\027\021\031 \017\035\017 2 \(0; 13\)\ )Tj /Span<>> BDC ( )Tj EMC 14.346 0 Td (% \023\030\036\007\023\024\004\035\017 \031\f\021\026)Tj 0 Tw (-)Tj -0.014 Tw -14.346 -1.218 Td (\027\024\r\022\031 \007\030\036\027\026\032\036\005 \022)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\005 \002\030\033\001\017\027\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026 \f\036\007\026\035\017\013\027\t\036 )Tj 0.036 Tw 23.244 15.831 Td (\002\031\020\030\t, \026)Tj /Span<>> BDC ( )Tj EMC (6/48 \030\036\f\023\024\027\007\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 14 \(5; 29\))Tj /Span<>> BDC ( )Tj EMC 17.334 0 Td (% \024\030\017\036\027\021\017)Tj 0 Tw (-)Tj -17.334 -1.218 Td (\030\031\033\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\027\031 \023\026\035\034\006\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.018 Tc 0.021 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \020\035\031\002\017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.042 Tw T* [(\027\t \007\030\036\027\017\030\024\r\026\027\017\016 \023\026\030\026\030\ \036\022\021\026\035\034\027\024\005 \022\035\036\021\004\026\021\022\017\ \f\030\036\007\017)18( )]TJ 0.017 Tw T* (\030\036\f\023\024\027\007\036\027\021\024\r \017\f\f\035\036\007\031\036\ \n\t\b \211\204\215 \027\036 \r\t\016\r\035\036\027\024 \(\022\030\017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.089 Tw T* (\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\n\036\027\026\ \226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tc 0 Tw (\032)Tj /T1_0 1 Tf 0.018 Tc 0.089 Tw /Span<>> BDC 15.592 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,63\). \222\030\036\007\017)18.1( )]TJ 0.519 Tw -15.592 -1.218 Td [(\r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\r \027\026\017\002\ \024\035\036\036 \023\030\036\007\023\024\004\021\017\021\036\035\034\027\ \024\005)18( )]TJ 0.067 Tw T* (\020\035\031\002\017\027\024\005 \031\f\021\026\027\024\r\022\017 \023\026\ \030\026\030\036\022\021\026\035\034\027\t\b \007\030\036\027\026\032\036\ \005 \016\r)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.033 Tw T* (\035\016\035\026\f\034 8\22610)Tj /Span<>> BDC ( )Tj EMC (\f\n 21/48 \017\035\017 44 \(29; 59\))Tj /Span<>> BDC ( )Tj EMC 16.484 0 Td [(%. \210\021\n\036\004\036\027\024,)18( )]TJ 0.078 Tw -16.484 -1.218 Td (\004\021\024 3/48 \030\036\f\023\024\027\007\036\027\021\026 \017\035\017\ 6 \(1; 17\))Tj /Span<>> BDC ( )Tj EMC 15.709 0 Td (% \024\f\031\013\036\f\021\r\035\016)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.111 Tw -15.709 -1.218 Td (\033\021 \031\f\021\026\027\024\r\022\031 \023\026\030\026\030\036\022\021\ \026\035\034\027\t\b \007\030\036\027\026\032\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.035 Tw T* [(\027\031 \002\024\035\036\036 15 \f\n, \021\024\020\007\026 \022\026\022\ 8/48 \b\017\030\031\030\020\024\r \017\035\017 17 \(7;)18.1( )]TJ 0.205 Tw T* (30\))Tj /Span<>> BDC ( )Tj EMC 1.567 0 Td (% \031\f\021\026\027\026\r\035\017\r\026\033\021 \007\030\036\027\026\032\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\031 \007\024)Tj /Span<>> BDC ( )Tj EMC [(7 \f\n)18( )]TJ 0 Tw -1.567 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \205\033\031\024\031\240\013 \030\022\024\023\020\f\017\025\031\b\031 \031\ \023\026\013\021\020\025\022\t \031\023\n\f\005\007\027\025\025\031\235 \ \007\020\024\023\022 \023)0.5(\031\f\024\023\031\235 \n\022\213\n\022 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.076 Tc 0.076 Tw 0 -1.2 TD [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.25 0 Td [( M)-2(e)-8.6(t)-10.6(h)-2.4(o)-11.9(d)-5.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-3(i)6.7(s)-14.9(t)-1.9(a)-4.5(l w)5.1(a)-7.2(s)5.1(h)1.7(i)3.9(n)-0.6(g o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e d)-3(i)6.6(sc)2.9(o)-4(n)0.8(n)-2.4(e)-10.9(c)-32.4(t)-1.6(e)-12.9(d p)-6.3(a)-4.1(r)-41.9(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e c)2.9(o)-5.3(l)-1.6(o)-4(n i)3.9(n c)3.2(a)-7.1(s)0.5(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.1(p)-11.3(e)-6(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l w)2.2(o)-3.3(u)0.6(n)-4.8(d)-5.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 204.3445 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 249.6988 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 295.0532 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 340.4075 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 385.7618 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 431.1161 715.181 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 204.3445 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 249.6988 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 295.0532 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.4075 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 385.7618 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 431.1161 694.1118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 694.1118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 682.6425 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 671.1813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 682.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 682.6425 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 652.2313 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 204.0945 671.1813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 249.6988 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 295.0532 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 340.4075 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 385.7618 671.1813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 431.1161 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 479.0551 671.1813 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 651.9813 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 640.52 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 651.9813 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 651.9813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 621.5699 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 204.0945 640.52 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 249.6988 640.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 295.0532 640.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 340.4075 640.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 385.7618 640.52 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 431.1161 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 479.0551 640.52 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 621.3199 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 609.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 621.3199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 621.3199 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 598.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.0945 609.8587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 609.8587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 609.8587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 609.8587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 609.8587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.0551 609.8587 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 598.3974 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 586.9361 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 598.3974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 598.3974 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 575.7249 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.0945 586.9361 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 586.9361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 586.9361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 586.9361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 586.9361 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.0551 586.9361 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 575.4749 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 204.3445 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 575.4749 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 575.4749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 564.0135 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 204.3445 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 249.6988 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 295.0532 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 564.0135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 479.3051 564.0135 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 542.9523 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 204.3445 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 542.9523 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 479.3051 542.9523 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 82.551 706.5464 Tm (\255\212\002\217\002\206 \240\t\217\003\004\f\001\b\002\n\002 \002\003\214\ \013\004\b\t\235 )Tj 3.657 -1.2 Td (\003\002\f\217\003\002\005 \220\t\230\220\t)Tj 12.422 0.6 Td (\255\t\214\002\f\013)Tj 5.46 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_3 1 Tf 7.776 0.001 Td (\t)Tj /T1_2 1 Tf 4.881 -0.001 Td (\026\217\r\n\002)Tj /T1_0 1 Tf -52.279 -2.033 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_3 1 Tf 18.821 0 Td (N)Tj /T1_2 1 Tf 5.426 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_3 1 Tf 5.846 0.001 Td (\226)Tj /T1_2 1 Tf 5.568 -0.001 Td (75)Tj /T1_0 1 Tf -52.948 -1.433 Td (\232\036\030\036 \026\027\026\035\034\027\t\005 \022\026\027\026\035)Tj /T1_1 1 Tf 18.884 0 Td (n)Tj /T1_0 1 Tf 5.669 0 Td (7)Tj 5.669 0 Td (0)Tj 5.419 0 Td (11)Tj 5.919 0 Td (2)Tj 4.754 0 Td (0,002*)Tj /T1_1 1 Tf -0.636 -1.2 Td (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 443.5219 667.08 Tm (3-2)Tj /Span<>> BDC 8 0 0 8 449.8276 664.416 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj /T1_1 1 Tf -1.555 -1.2 Td (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 441.5219 657.4799 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 447.8276 654.8159 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.269 2.4 Td (20)Tj /T1_1 1 Tf -34.894 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.434 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(11; 55\))Tj 6.169 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.169 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(25; 75\))Tj 5.919 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(2; 64\))Tj 11.443 0 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(17; 38\))Tj -51.245 -2.4 Td (\232\036\030\036 \f\021\024\n\031)Tj /T1_1 1 Tf 18.884 0 Td (n)Tj /T1_0 1 Tf 5.419 0 Td (10)Tj 5.669 0 Td (16)Tj 5.919 0 Td (3)Tj 5.669 0 Td (6)Tj 4.025 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 463.8116 646.0187 Tm (-4)Tj 8 0 0 8 467.7853 643.3547 Tm (*)Tj /T1_1 1 Tf -3.515 -1.2 Td (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 443.7993 636.4187 Tm (4-3)Tj /Span<>> BDC 8 0 0 8 450.105 633.7547 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 465.8328 636.4187 Tm (\2264)Tj /T1_1 1 Tf 8 0 0 8 437.3859 624.1547 Tm (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 441.5219 626.8187 Tm (4-5)Tj /Span<>> BDC 8 0 0 8 447.8276 624.1547 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,019)Tj 6.269 2.4 Td (35)Tj /T1_1 1 Tf -34.894 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.434 0 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(18; 68\))Tj 5.669 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(51; 95\))Tj 5.919 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(2; 40\))Tj 5.419 0 Td (67)Tj /Span<>> BDC ( )Tj EMC (\(26; 94\))Tj 11.693 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(35; 59\))Tj -51.245 -2.4 Td (\232\036\030\036 \f\021\024\n\031 \017)Tj T* (\026\027\026\035\034\027\t\005 \022\026\027\026\035)Tj /T1_1 1 Tf 18.884 1.2 Td (n)Tj /T1_0 1 Tf 5.669 0 Td (1)Tj 5.669 0 Td (3)Tj 5.669 0 Td (2)Tj 5.669 0 Td (0)Tj 5.004 0 Td (0,51*)Tj 6.689 0 Td (6)Tj /T1_1 1 Tf -35.144 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.934 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 25\))Tj 5.169 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(25; 42\))Tj 6.169 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(1; 34\))Tj 5.786 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;43\))Tj 11.576 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(3; 17\))Tj -51.745 -1.433 Td (\203\036 \024\021\n\t\r\026\033)Tj /T1_1 1 Tf 18.884 0 Td (n)Tj /T1_0 1 Tf 5.669 0 Td (6)Tj 5.669 0 Td (1)Tj 5.669 0 Td (6)Tj 5.669 0 Td (1)Tj 5.004 0 Td (0,26*)Tj 6.439 0 Td (14)Tj /T1_1 1 Tf -34.894 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.684 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(8; 52\))Tj 5.919 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(0; 31\))Tj 5.169 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(10; 56\))Tj 5.919 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(0; 57\))Tj 11.443 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(11; 29\))Tj /T1_1 1 Tf -51.245 -1.433 Td (p)Tj /T1_0 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_1 1 Tf 18.895 0 Td (p)Tj /T1_0 1 Tf 12.951 0 Td (1,3\26710)Tj /Span<>> BDC 4.664 0 0 4.664 348.1206 569.5123 Tm (-)Tj EMC (4)Tj 8 0 0 8 73.9508 555.387 Tm (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_1 1 Tf (V)Tj /T1_0 1 Tf ( )Tj T* (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_1 1 Tf 18.894 1.2 Td (V)Tj /T1_0 1 Tf 11.127 0 Td (0,35)Tj /Span<>> BDC ( )Tj EMC (\(0,13; 0,53\))Tj /T1_1 1 Tf 7 0 0 7 70.8661 531.4677 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ T* (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020; \032)Tj 4.081 0 0 4.081 331.8351 525.3987 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 342.1558 523.0677 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj ET q 70.866 169.05 198.762 147.391 re W n q /GS0 gs 198.7624821 0 0 147.3915086 70.8661514 169.0494184 cm /Im0 Do Q Q BT /T1_1 1 Tf 0.003 Tw 8 0 0 8 70.8661 159.4394 Tm (\004\032\022\026\027\007\020\025\022\027: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027\032\027\016 \020\025\020\f\017\025\013\235 \n\020\025\020\f\ , 2)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027\032\027\016 \024\023\031\026\r, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027)Tj 0 Tw (-)Tj T* (\032\027\016 \024\023\031\026\r \022)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\013\235 \n\020\025\020\f, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027 \031\023\026\013\021\020\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw 9 0 0 9 70.8661 133.3701 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\220\022\020\b\032\020\026\026\020 )0.7(\032\020\024\033\032\027\030\027\f\027\025\022\t )0.6(\030\031\f\027\235 )0.6(\033\032\022\026\027\025\t\027\026\013\200 )]TJ 0.04 Tw T* (\032\027\024\033\031\025\030\027\025\023\020\026\022 \024\033\031\024\031\ \240\031\021 \030\022\024\023\020\f\017\025\031\b\031 \031\023\026\013\021\ \020\025\022\t \031\023\n\f\005)Tj 0 Tw (-)Tj T* (\007\027\025\025\031\235 \007\020\024\023\022 \023\031\f\024\023\031\235\ \n\022\213\n\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.336 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Diag)14.1(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the distr)-37(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(ropor)-40(tions )]TJ 0.073 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(methods used by respondents for distal w)13(ashing of)]TJ /Span<>> BDC ( )Tj EMC (the dis)Tj 0 Tw (-)Tj T* [(connected par)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(the colon in e)-14.8(xtraper)-36.9(itoneal rectal w)12.1(ounds)]TJ ET q 303.307 169.04 192.371 147.401 re W n q /GS0 gs 192.3715316 0 0 147.460826 303.3071116 168.9801569 cm /Im1 Do Q Q BT /T1_1 1 Tf 0.036 Tw 8 0 0 8 303.3071 159.4394 Tm (\004\032\022\026\027\007\020\025\022\027: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \240\022\f\020\023\027\032\020\f\017\025\031 \033\020\032\020\032\027\ \n\023\020\f\017\025\031, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\027\024\020\n\032\020\f\017)Tj 0 Tw (-)Tj T* (\025\031, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027\032\027\016 \032\020\025\r, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027 \030\032\027\025\022\032\r\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw 9 0 0 9 303.3071 133.3701 Tm [(\022\t\217\210\b\002\220 )0.6(3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\220\022\020\b\032\020\026\026\020 )0.7(\032\020\024\033\032\027\030\027\f\027\025\022\t )0.6(\030\031\f\027\235 )0.6(\033\032\022\026\027\025\t\027\026\013\200 )]TJ 0.586 Tw T* (\032\027\024\033\031\025\030\027\025\023\020\026\022 \024\033\031\024\031\ \240\031\021 \033\027\032\022\025\027\020\f\017\025\031\b\031 \030\032\027\ \025\022\032\031\021\020\025\022\t )Tj 0 Tw T* (\n\f\027\023\007\020\023\031\007\025\013\200 \033\032\031\024\023\032\020\ \025\024\023\021 \023\020\016\020 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.013 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Diag)14(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the distr)-37(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(ropor)-39.9(tions of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj -0.032 Tw T* (methods of)Tj /Span<>> BDC ( )Tj EMC [(per)-37(ineal drainag)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC (the cellular spaces of)Tj /Span<>> BDC ( )Tj EMC (the pelvis )Tj 0 Tw T* [(used by respondents in e)-14.8(xtraper)-36.9(itoneal rectal w)12.1(ounds)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7902 56.0378 Tm (108)Tj ET endstream endobj 946 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;4 4  y!16s3"AQRSa#ETqu2U $%&'()*45789:BCDFGHIJVWXYZbcdefghijrtvwxyz?ЪKMwj>؊u7[fj}H\(iAJ^W%tJ|JŜ(8R2K)%(JRJVR:Jj'S_6y 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VwHkzPЪw6}ĥio!fO"6d ƣɑDK)mJtd^eq4 ]7niwwg ͧ&f"UvK6IİIDIIDW!y=IzZsojRP+Iܫe(&8 >1ffhmy;tZd)p!La*Sdwl.K&Ԥ'xi--"1SXx0G`0l6|nx >7<{ =Ύ#CY%w_QYC"Ǹ`\9#Ǥ`^xݘ38 6|\Gc5FluE}QHj1sǸ(Eϕ6>7<{nxf=$5.(46|nx >7<{<6|nx x1|.;ycIΎY{>7<{ =ύ჊0l6|nx pҒiIčsydѪ6@t} $\g妉j )"2M|jӌiVN-"Rȉ$f\}<(dGueyg /26$JJ*[s1-"\U7*FTĔ)-8y8i5apBUPˍg I̔3.YJ* @ݦ٤B*)--WrI2R^1SI?Ö &X # a3Jm!W$Gg$"-d#-B9 d#-B9 d#- !Ž-%'zdp)SxuZ2l~re 2#ZNJ⑐t-n2Ζ- G:[ sC%Mؽ]WkG:[t-n8Z9 ps@hKpΖ Г~U[ir2C^B9 d#-B9 d#-B9 psBU*ɦ3I&I/q򃅏 YZf?,ٚ_<V!n2Ζ!n2Ζ!n2Ζ9w523x0ҪUIF}52%2UĮx=pՈl-%§,“~+ȅ:ѱLѻ2A^ ljF! $|2\:aETmkCnLuiD(22~>\I/_~{$f6Sj~G\H[|iukn 2߰ƺƟ6 VwHkzu(ӪMZm%%Ʋ̲MH;ȏT-uFlh5>2\n H-  LVҖ+DCW g&%n^R[qZI/xb0(qWB2*xxQ'q643/*UjK樒ԗbY :YT5Bq=G'^ Fyk<02]*QdVXn69`#^69`#^8>l_j0d9}2׺]8'ϯtEx']8}{ !6o,rCWϯtOG>q=G'^siSZAf#xs(pɖ/RI;lԞqp83ѓTx}{sg`ЖuI>DLXo3 -Y!@Ъ֔!sm M0ɨJNʹd[3fJ5ޒÙxi*zra^2J͹33<;aҭ US" 8I4hI!5t\z-FK.J,IykX~5k)e=3"y<,35;&n{ %Oɯ!yHVX(&RDJ_kfs5n4q$m%BI).a=#p^і4iL#j gt@eѪ-]:lG"4n-IderD|=- .ܸQ8ѡq$p(2УT"hfYɞ-[27R`>VW4zv %jL2&3f}I&Wx6kKX$U$px\*l#W_=qB<H[tv 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#$%'()*36789:CDEFGHIJVWXYZcdefghijtuvwxyz?Ъ8%%XyDCﴧԧm$T [냀9in:L4Ͳt漣] tTx$|SaCC-(և D0U23PѪ慓\LQ4VZPx-ժ`'{o=ބ* =pIBh r-y1D8R[2VL*7"b]~1C4J&t -͹:TJS$VQ:Њ/O~ hEpo4"x7߃\ ƄOz{^)Zo^(ʚr(*sFЊ/O~ hDo4"7߃< ƄOz{sF(WY4׊abQ`Nk ƄOz{cB+x=1^Њ/O~ hDok&%!J(,Ѷ4"x7߃\ ƄWz{cB'x=1^yvi6ڜxΊs v>N1^,I#ɩW^Њ/O~ hDo4"7߃< FI39QE2*Q:t,ҪԔ$:Um-J0ġ %.$Dy YCL$(<H^\DPT-m,ى.$ư;|0Ԋmx}V{ZLh>M`Ul:իB6ޡqXeӪ^iZ[NF fI-3|A8ҒBd!Ḙwhi8*Jt"gKc1.̒FULΡqPQ TZNF}mRVԙ(¶Sed@m\W| gmx|A֭Zz~z@Ԫ\&W,IA R֩SDEL5:mg'Pm*5̞KIQ(e2IFIlpH23rTSʳG" 'ƺhB^6 uHZclɇ7]=sP=~ P=~ P=~ P=~ P=~2};y6 Pt(:ȔK3>F\b1 SĵR'Kd"MJ#scU*uj=~ P=~ >zN|;ڝ1@;ڝTyew6\:u!48zNzNzNzNzNzN}emzڍ,-8|;ڝ1@;ڝ0w;ajwjwqƦ,.Rdp{ il!d'qw;ajwjwx# * 4ժܹ$KEmT3Ϋ]fj%%TN}2 +D,lmm4x64):#3*2Tc_ehi)D 5KGE,RےL{OMMiszV{ZLh>I`UlJ٫DP߆P֪ gnKc1. >It&gBY:',zФDlA$6$$Υ%TSbXDT#y I¶Sed@M\W| gmx|A֭ZzaתZnrvGCfnUL#* %qPemr+3e hVgBi1ؖ܅TMRh[.(DJ3:E@[;r]I`vv`?ѕ)$ES:jz-1Fq &i*Jn)P OtcI|=h>I`Ul:իBP2Ъvn:dcBM(}i#*ct XM05JJte*32oKDKE]rSA*@Jj")qIJУM:#Dd>ǂs$ĺDO;YNx0%+x $w ;\ⷀNxo6}ŶM+Iddy%%aHгM!58TN Sٽ #'8 4U*3:j.[a'tKewD[a'tKVI t ;y7UٔKUjiNtx $wLNtx $wLNtx $wL.Pi8eq.L].IwDo.[atKewDoqnĻQ X7N.,]ⷀ.x0%+x $w]ⷀ.tx8FښRΕQHhѪi$ȔD#,=T(a'-Nô׳)% Y7;>}G,W!(E^uV6ޡqXeӪ'$L+,`FMFX%SDYc1svVĘWdCfid4Di<2 @rSItu6jj:Q5ADBBiAGT֘ōծAV/H|t aΗ >YqRȆyp)ǐڍBR'LK88dq]JKM&IիNXH2ĩ'j"J%4L ꎆ,z@,|taΖGV^O$Zygt aΗ Y;X0gKGøZ["XL3eQ5/H|t aΗ >Y:^){=Ձ4IJsC@ԪxumO8JRyETp#ʑg^!nB4LY%,Sj^C')&ٞ %5H=>6QBcL8)6Y&6ȩuJ''q9'(sQ$"kgnKc1;|0Պ>Zmx}V{ZLh>I`Ul:իDP2ժT(N QzH()pzԺ$ECPzR,<Z`"RM)I(,@2.$ư(;|0Ԋ᭕x}V{ZLh>I`Ul:իBP2֪*H4(*cE# D+ Y yE!XwTV(ʓIT1 rKSsLZT9ZBRTgWt<"_eiyt%-tP]52*y]6%XGYYDPt8ۚLz )ϝEWpʼ>|+e=я&VMQ$w}*vWjա iw~V@ת|RCʱR3m QkR+IIe>+[!n'$I<´1 \mkxYK3L"iI"5eUB`gjTE+i %%N2je8!G0 Kv1(2U 5TtdQӕ&\D^)FBtT:Td1do:t:le NN|ϝӟ;0bzsuF ON|QvյnQӟ;'>wT`ꁉϝI+ی}y>+mZҦ$}ON|ϝӟ;0bzsu@Qh׮igiϝ1=9bzsu@P1=9@%,8zڈVո 8f_;U`;''>wT NN|P199brsuF8&3=JR ,Y4Ъ#„rr4̯(DIGKKef(#:sQIʔl(&=L/IAH&:"[JD4ie9.N;lPI-Y4揯'I}qRtP,*Z t>Mlwq&5E>Uu n¶Sed@m\W| gmx|A֭ZzaѪ)7xqMbԢqH%x#MJFP3wefV'QMSR>2*Ҍ cK~:jRRlg@N S}p|cQ6FjBJn*v8"R*U[)}i2otw}Y6+CQU> Vl OCҪ%ϙ:NL[2L% F"3:Ẍ́2z./]G2"<,y-$@-Ѵ7EF!gr (쪡eP̍ԥF{ 3I 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gnkc1. "ke^l9GWΠ>M`R#2-Y&Y I8f`,(n OC~@ԪrN8iNۏ(iJ"2#&>hXd ՀJi=pN P *aP<N`0U234Mlwq&5E>Uw n|s. ɑ1jE#Si5A6qpy*)8'gi2hWa `}G,W!*&(xtb\,iT4E&T5rs:%N9L:K9*NAzaժӕN](gh Ȋ!Q+Spѳ% JYUHz.$ǰ(;|0Ԋmx}F>Y71p眶ߛR=IjQF?(Qz%E`Dd{fS.pj烈^72Ԛ*C N(q F)hRp%AJ9ͦ\ 8cDj5v7HEI @-?ۊ(ЪgcSj!ekqm5IdN,U r%Y& mF1CeH4RZ M':JGbTpp~ p ZP҄kNi:IL3DuèT!̟b f |+,W1b?Bq^P.<˅ Cff|d f |+|Oб\Fc2~3ψ#"e d f |+|cOб\Fc8$-HRkqK$#Tݗ)< SS`VT$6A:L>`4,W1'X#1?Bq|+б\FaZt7[6uҡћJ:NHjnEC)>zIdEmFIӐqb?Bq0+б\F`3>`4,W|Rj6eE!Ju8ÀѪ9G)vH~M58Dh^M Azd8P,cd)ai)Du>KF2, QT7`Ry$ZCm@#m-"ii0KHFZC'ĻÍk&4Ӛ>iim@#m-"ii0KH*SzG|tȕ232#3ep % +mi%%Ixm@#m- `0KHm<><3+|mԵ""1d~CԴq 5J9t9>0 - `0KHm@#m-"IˌZan.I S$T2:cii0KHFZD 6ii0KHFZCEDCҪ> G![ypp:iܑ9'1$9jKZ6q2#3Q&@^Y)m&:VQ]Y BJ*Gޙ\L7 cIi*%v} fJ`=J&V(ҕ`0X%iRAX&{ADJml P'jX3"M2O'QKqu)F%)芛BHd¬):JH}Ӫȓ#e XAtQ4pPSvR`rQ {j6"raMjPf(DLASqkeJL}zFj]ʩ% HZj. lJnPҔLrRxU 7PJ=UNPYߕab+Pq"Q(Pc$Ip4ĝ Kl R U3:Ԫժ endstream endobj 955 0 obj <>stream endstream endobj 954 0 obj <>stream endstream endobj 944 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.102 Tw 10 0 0 10 42.5197 274.2439 Tm (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \b\017\030\031\030\020\017\004\036\f\022\017\005 \f\021\026\ \032 \f\023\036\006\017\026\035\017\f\021\024\r \027\036 \r\035\017)Tj 0 Tw (-)Tj 0.021 Tw 0 -1.218 TD (\016\035 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \007\017\f\021\026\035\034\027\024\020\024 \024\ \021\n\t\r\026\027\017\016 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030 )Tj -0.027 Tw T* (\021\036\b\027\017\004\036\f\022\024\020\024 \r\026\030\017\026\027\021\026\ \030\036\026\035\017\026\006\017\017 \007\026\027\027\024\020\024 \220\ \035\036\n\036\027\021\026 )Tj 0 Tw T* (\025\024\027\006\036\023\006\017\017 \(\024\007\027\024\235\026\022\021\024\ \030\027\t\005 )Tj /T1_2 1 Tf -0.053 Tc 0.053 Tw [(AN)-33(O)-37(V)-11(A)]TJ /T1_1 1 Tf 0 Tc 0 Tw 14.582 0 Td (, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56\).)Tj 0.028 Tw -14.582 -1.218 Td (\222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\ \r 14/75 \017\035\017 19 \(11; 29\) % \027\036 )Tj 0 Tw T* (\r\t\023\024\035\027\016\033\021 \007\017\f\021\026\035\034\027\024\036 \ \024\021\n\t\r\026\027\017\036 \022\017\001\022\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj /T1_3 1 Tf 0.063 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2365:)Tj /T1_1 1 Tf ( \253\025\026\022\017\n \f\023\024\f\024\002\024\n \200\t \r\t\023\024\035\ \027\016\036\021\036 \023\036\030\017)Tj 0 Tw (-)Tj 0.309 Tw 0 -1.218 TD [(\027\036\026\035\034\027\024\036 )0.6(\007\030\036\027\017\030\024\r\026\027\017\036 )0.5(\022\035\036\021\004\026\021\024\004\027\t\b )0.6(\023\030\024\f\021\030\026\027\f\021\r )]TJ 0 Tw T* (\021\026\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017\ \023\030\016\n\024\005 \022\017\001\022\017?\273)Tj 0.002 Tc 0.594 Tw T* (\215\030\036\007\023\024\004\017\021\026\036\n\t\036 \030\036\f\023\024\027\ \007\036\027\021\026\n\017 \f\023\024\f\024\002\t \030\031\021\017\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.204 Tw T* [(\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \022\035\ \036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\ \r \021\026\026)2( )]TJ 0.077 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\031\036\n\t\b \211\204\215 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\024 \027\036 \030\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 1.002 Tw T* [(\035\017\004\026\035\017\f\034 \(\022\030\017\021\036\030\017\005 \205\017\ \001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\ \026,)2( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (p)Tj /T1_1 1 Tf 0.002 Tc 0.182 Tw /Span<>> BDC 0.48 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,077\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\). \222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\ \024\r \027\026\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.364 Tw -0.48 -1.218 Td (\002\024\035\036\036 \004\026\f\021\024 \023\030\017\n\036\027\016\035\f\ \016 \002\017\035\026\021\036\030\026\035\034\027\t\005 \023\026\030\026\ \030\036\022)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.077 Tw T* [(\021\026\035\034\027\t\005 )0.5(\f\023\024\f\024\002 )0.5(\007\030\036\027\017\030\024\r\026\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 13.201 0 Td [(\227 )0.5(54/75 )0.5(\017\035\017 )0.5(72 )0.5(\(60;)2( )]TJ 0.331 Tw 10.043 19.485 Td (82\))Tj /Span<>> BDC ( )Tj EMC 1.503 0 Td [(%. )0.5(\215\030\036\f\026\022\030\026\035\034\027\t\005 )0.5(\f\023\024\f\024\002 )0.5(\r\t\002\030\026\035\017 )0.6(15/75 )0.6(\030\036)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.176 Tw -1.503 -1.218 Td (\f\023\024\027\007\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 20 \(12; 31\))Tj /Span<>> BDC ( )Tj EMC 11.639 0 Td [(%, \021\024\020\007\026 \022\026\022 \004\036\030\036 \030\026\027\031)2( )]TJ 0.179 Tw -11.639 -1.218 Td [(\007\030\036\027\017\030\024\r\026\035\017 )0.6(2/75 )0.5(\b\017\030\031\030\020\024\r)]TJ /Span<>> BDC ( )Tj EMC 12.409 0 Td [(\227 )0.5(3 )0.5(\(0,3; )0.5(9\))]TJ /Span<>> BDC ( )Tj EMC 5.621 0 Td [(%. )0.5(\025\030\024\n\036)2( )]TJ -0.012 Tw -18.031 -1.218 Td (\021\024\020\024, 4/75 \030\036\f\023\024\027\007\036\027\021\026 \017\035\ \017 5 \(1; 13\) % \(3/22 \030\036\f\023\024\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.057 Tw T* (\007\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (4 \211\204\215 \017)Tj /Span<>> BDC ( )Tj EMC (1/9 \030\036\f\023\024\027\007\036\027\021 \f)Tj /Span<>> BDC ( )Tj EMC [(5 \211\204\215\) \007\024\023\031\f\022\026\035\017)2( )]TJ 0.042 Tw T* [(\r\024\n\024\032\027\024\f\021\034 \024\021\022\026\026 \024\021 \024\002\ \016\026\021\036\035\034\027\024\020\024 \007\030\036\027\017\030\024\r\ \026\027\017\016)2( )]TJ -0.006 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r \021\026\026 \023\036\030\017\027\036\026\035\034\027\t\n \007\ \024\f\021\031)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.031 Tw T* (\023\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\). \200\t\002\024\030 \f\023\024\f\024\002\026 \023\026\030\026\030\036\ \022\021\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.094 Tw T* [(\027\024\020\024 )0.6(\007\030\036\027\017\030\024\r\026\027\017\016 )0.6(\017\035\017 )0.6(\024\021\022\026 )0.6(\024\021 )0.5(\027\036\020\024 )0.6(\027\036 )0.6(\026\r\017\f\036\035 )0.6(\024\021)2.1( )]TJ 0.085 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \f\021\026\032\026 \ \f\023\036\006\017\026\035\017\f\021\026 \(\024\007\027\024\235\026\022\021\ \024\030\027\t\005)2( )]TJ /T1_2 1 Tf -0.051 Tc 0.051 Tw T* [(AN)-33(O)-37(V)-11(A)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw 2.543 0 Td (, )Tj /T1_2 1 Tf 0 Tc 0 Tw 0.422 0 Td (p)Tj /T1_1 1 Tf 0.002 Tc /Span<>> BDC 0.48 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,26\).)Tj /T1_3 1 Tf 0 Tc -0.045 Tw -3.445 -2.436 Td [(\026\002\212\006\002\217 )0.5(\2366:)]TJ /T1_1 1 Tf [( \253\200 \b\024\007\036 )0.5(\r\t\023\024\035\027\036\027\017\016 )0.5(\023\036\030\017\027\036\026\035\034\027\024\020\024 \007\030\036)]TJ 0 Tw (-)Tj 0.139 Tw T* (\027\017\030\024\r\026\027\017\016 \022\035\036\021\004\026\021\024\004\027\ \t\b \023\030\024\f\021\030\026\027\f\021\r \021\026\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036)Tj 0 Tw (-)Tj -0.061 Tw T* (\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\ \016\n\024\005 \022\017\001\022\017, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\031\033 \020\035\031\002\017\027\031 )Tj -0.014 Tw T* (\031\f\021\026\027\026\r\035\017\r\026\036\021\036 \023\026\030\026\030\036\ \022\021\026\035\034\027\t\005 \007\030\036\027\026\032 \(\f\n\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\017\n )Tj 0 Tw T* (\024\030\017\036\027\021\017\030\024\n \023\024\035\034\031\036\021\036\ \f\034 \007\035\016 \220\021\024\020\024?\273)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.08 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\033\031\024\031\240\013 \203\031\032\026\022\032\031\021\020\025\022\ \t \032\027\024\033\031\025\030\027\025\023\020\026\022 \030\022\021\027\ \032\024\022\031\025\025\031\235 \n\031\f\031\024\023\031\026\013 \025\020\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025)Tj 0 Tw (-)Tj 0 -1.2 TD (\024\n\031\235 \033\031\026\031\212\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\024\023\032\r\n\023\022\021\025\013\200 \211\240\206\004\ \202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.01 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.017 Tw 3.306 0 Td [( M)-2(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(f)-13.4(o)-3(r)-18.5(m)1.3(i)3.9(n)-0.6(g a)]TJ /Span<>> BDC ( )Tj EMC [(d)-3(i)-2.9(v)2.3(e)-6(r)-14.9(s)-12.5(i)-2.9(v)2.3(e c)2.8(o)-5.3(l)-1.5(o)-1.1(s)-14.8(t)-3(o)-4(my b)-2.4(y r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-6.9(n)-0.7(t)-32.8(s a)-9.1(t v)6.3(a)-4.2(r)-39(i)-1.4(o)-3.4(u)-4.4(s le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-2.9(i)-1.8(c)3.2(a)-4.5(l c)3.2(a)-4.2(r)-2(e f)-13.4(o)-3(r n)-2.4(o)-4(n)-13.4(-)-29.4(d)-5.3(e)-22(s)-14.8(t)-9.6(r)-9.1(u)-3.7(c)-32.4(t)-29.1(i)-2.9(v)2.3(e e)-32.4(x)-32.5(t)-9.6(r)3.4(a)-5.2(p)-11.3(e)-6(r)-39(i)]TJ 0 Tw 46.792 0 Td (-)Tj 0.002 Tc -0.002 Tw -50.098 -1.2 Td [(t)-1(o)-2(ne)-5.5(a)-2.5(l)2( re)-8.9(c)-30.4(ta)-2.5(l)2( w)4.2(o)-1.4(u)2.6(n)-2.8(d)-3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 158.9902 693.581 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 221.3524 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 266.7067 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 312.061 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 357.4153 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 402.7697 693.581 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 693.581 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 672.5118 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 672.5118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 221.3524 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 312.061 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 357.4153 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 402.7697 672.5118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 672.5118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 661.0425 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 649.5813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 661.0425 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 661.0425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 661.0425 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 638.37 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 649.5813 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 649.5813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 649.5813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 649.5813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 649.5813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7086 649.5813 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 638.12 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 626.6587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 638.12 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 638.12 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 638.12 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 607.7087 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 158.7402 626.6587 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 221.3524 626.6587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 266.7067 626.6587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 312.061 626.6587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 357.4153 626.6587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 402.7697 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 450.7086 626.6587 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 496.313 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 42.5197 607.4587 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 595.9974 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 607.4587 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 607.4587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 607.4587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 577.0474 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 158.7402 595.9974 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 221.3524 595.9974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 266.7067 595.9974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 312.061 595.9974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 357.4153 595.9974 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 402.7697 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 450.7086 595.9974 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 496.313 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 42.5197 576.7974 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 565.3361 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 576.7974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 576.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 576.7974 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 554.1249 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 565.3361 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 565.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 565.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 565.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 565.3361 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7086 565.3361 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 553.8749 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 158.9902 553.8749 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 402.7697 553.8749 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 553.8749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 542.4136 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 158.9902 542.4136 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 221.3524 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 266.7067 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 402.7697 542.4136 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9586 542.4136 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 521.3523 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 158.9902 521.3523 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 221.3524 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 402.7697 521.3523 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 450.9586 521.3523 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 61.3765 684.9464 Tm (\255\212\002\217\002\206 \226\002\006\214\t\006\002\004\b\t\235 )Tj 2.548 -1.2 Td (\220\002\f\002\217\003\002\214\013)Tj 11.571 0.6 Td (\255\t\214\002\f\013)Tj 6.523 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 7.776 0.001 Td (\t)Tj /T1_3 1 Tf 4.881 -0.001 Td (\026\217\r\n\002)Tj /T1_1 1 Tf -52.279 -2.033 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 17.758 0 Td (N)Tj /T1_3 1 Tf 6.489 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_4 1 Tf 5.846 0.001 Td (\226)Tj /T1_3 1 Tf 5.568 -0.001 Td (75)Tj /T1_1 1 Tf -52.948 -1.433 Td (\212\r\031- \017\035\017 \024\007\027\024\f\021\r\024\035\034\027\026\016\ )Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (9)Tj 5.669 0 Td (6)Tj 5.669 0 Td (5)Tj 5.669 0 Td (5)Tj 5.004 0 Td (0,45*)Tj 6.439 0 Td (25)Tj /T1_2 1 Tf -35.957 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.497 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(17; 64\))Tj 5.669 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(10; 58\))Tj 5.919 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(6; 50\))Tj 5.419 0 Td (56)Tj /Span<>> BDC ( )Tj EMC (\(18; 89\))Tj 11.693 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(23; 45\))Tj -51.245 -1.433 Td (\212\r\031\f\021\r\024\035\034\027\026\016 \023\036\021\035\036\r\026\016\ )Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.482 0 Td (11)Tj 5.919 0 Td (9)Tj 5.669 0 Td (2)Tj 5.669 0 Td (2)Tj 4.754 0 Td (0,035*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 622.5573 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 419.3252 619.8933 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,034)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 612.9573 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 419.3252 610.2933 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,049)Tj 6.289 2.4 Td (24)Tj /T1_2 1 Tf -35.957 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.497 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(23; 70\))Tj 5.669 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(21; 72\))Tj 6.169 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(1; 34\))Tj 5.419 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(2; 64\))Tj 11.443 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(22; 44\))Tj -51.245 -2.4 Td (\210\007\027\024\f\021\r\024\035\034\027\026\016 \022\024\027\006\036\r\026\ \016)Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (1)Tj 5.669 0 Td (0)Tj 5.669 0 Td (8)Tj 5.669 0 Td (0)Tj 4.754 0 Td (0,003*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 591.8961 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 419.3252 589.2321 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,029)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 582.296 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 419.3252 579.632 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013)Tj 6.539 2.4 Td (9)Tj /T1_2 1 Tf -36.207 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.997 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 25\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.169 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(15; 34\))Tj 6.169 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 11.443 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(6; 22\))Tj -51.495 -2.4 Td (\203\036 \r\f\036\020\007\026 \235\024\030\n\017\030\031\033)Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (3)Tj 5.669 0 Td (5)Tj 5.669 0 Td (7)Tj 5.669 0 Td (2)Tj 5.004 0 Td (0,46*)Tj 6.439 0 Td (17)Tj /T1_2 1 Tf -35.957 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.747 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(2; 36\))Tj 5.669 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(7; 54\))Tj 5.419 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(12; 60\))Tj 5.919 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(2; 64\))Tj 11.559 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(14;34\))Tj /T1_2 1 Tf -51.362 -1.433 Td (p)Tj /T1_1 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 17.832 0 Td (p)Tj /T1_1 1 Tf 14.133 0 Td (0,0032)Tj -31.965 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017)Tj /T1_2 1 Tf T* (V)Tj /T1_1 1 Tf ( \025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 17.831 1.2 Td (V)Tj /T1_1 1 Tf 12.19 0 Td (0,34)Tj /Span<>> BDC ( )Tj EMC (\(0,16; 0,53\))Tj /T1_2 1 Tf 7 0 0 7 42.5197 509.8676 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ 0 -1.2 TD (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020; \032)Tj 4.081 0 0 4.081 303.4887 503.7986 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 313.8094 501.4676 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.055 Tw 9 0 0 9 42.5197 482.1636 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\031\f\t \032\027\024\033\031\025\030\027\025\023\031\021, \033\032\ \022\026\027\025\t\005\212\022\200 \023\032\020\025\024\f\005\026\022\025\ \020\f\017\025\031\027 \r\213\022\021\020\025\022\027 \032\020\025\013 \033\ \032\t\026\031\235 \n\022\213\n\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\024\023\032\r\n\023\022\021\025\013\200 )Tj 0 Tw 0 -1.2 TD (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.136 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.109 Tw 3.437 0 Td [( )0.5(T)-6.3(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC 2.062 0 Td [(p)-2.8(r)-2(o)-5.3(p)-9.1(o)-3(r)-41.9(t)-29(i)-1.4(o)-4(n )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 5.686 0 Td [(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.2(e)-7(n)-0.6(t)-32.9(s )0.5(u)-4.4(s)-12.5(i)3.9(n)-0.6(g )0.6(t)-9.6(r)3.3(a)-5.1(n)3.7(s)4.8(lu)0.7(m)1.3(i)3.9(na)-4.5(l )0.5(r)-2(e)-10.8(c)-32.4(t)-2(a)-4.5(l )0.5(w)2.3(o)-3.4(u)0.6(n)-4.8(d)-5.8(s )0.5(s)6.8(u)-4.8(t)-1.1(u)1.6(r)-39(i)3.9(n)-0.6(g )0.5(f)-13.4(o)-2.9(r )0.5(n)-2.4(o)-4(n)-13.4(-)-29.5(d)-5.2(e)-22(s)-14.8(t)-9.6(r)-9.1(u)-3.7(c)-32.4(t)-29.1(i)-2.9(v)2.3(e )0.6(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.3(e)-6(r)-39(i)-3.3(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l )0.5(r)-1.9(e)-10.9(c)-32.4(t)-2(a)-4.5(l )]TJ -0.002 Tc 0.002 Tw -11.185 -1.2 Td [(wo)-5.4(u)-1.4(n)-6.8(d)-7.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 445.2617 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 161.8248 445.2617 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 224.187 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 269.5414 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 314.8957 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 360.25 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 405.6044 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 450.9587 445.2617 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 414.5924 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 161.8248 414.5924 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5414 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6044 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9587 414.5924 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 403.1232 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 391.6619 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.8248 403.1232 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 403.1232 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 380.4507 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.5748 391.6619 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 161.8248 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 391.6619 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 380.2007 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 368.7394 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.8248 380.2007 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 380.2007 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 380.2007 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 380.2007 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 380.2007 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 360.25 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 380.2007 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 357.5281 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.5748 368.7394 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 161.8248 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 368.7394 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 368.7394 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 368.7394 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 368.7394 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 360.25 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 368.7394 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 357.2781 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 357.2781 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 357.2781 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 345.8168 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 161.8248 345.8168 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 224.187 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 269.5414 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9587 345.8168 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 324.7555 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 161.8248 324.7555 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 224.187 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 450.9587 324.7555 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 80.4135 436.6271 Tm (\200\006\t\214\r\b\r\b\t\r )Tj -3.999 -1.2 Td (\003\006\004\b\217\f\211\214\t\b\004\f\001\b\002\n\002 \210\230\t\004\b\ \t\235 )Tj 2.287 -1.2 Td (\006\004\b\013 \212\006\235\214\002\005 \220\t\230\220\t)Tj 13.807 1.2 Td (\255\t\214\002\f\013)Tj 6.523 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 7.599 0.001 Td (p)Tj /T1_3 1 Tf 4.704 -0.001 Td (\026\217\r\n\002)Tj /T1_1 1 Tf -52.279 -2.633 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 18.113 0 Td (N)Tj /T1_3 1 Tf 6.489 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_4 1 Tf 5.669 0.001 Td (\226)Tj /T1_3 1 Tf 5.391 -0.001 Td (75)Tj /T1_1 1 Tf -52.948 -1.433 Td (\212\026, \023\030\017\n\036\027\016\033)Tj /T1_2 1 Tf 18.175 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (7)Tj 5.419 0 Td (16)Tj 5.669 0 Td (13)Tj 5.919 0 Td (3)Tj /T1_4 1 Tf 5.641 0 Td (\226)Tj /T1_1 1 Tf 5.447 0 Td (39)Tj /T1_2 1 Tf -35.602 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.497 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(15; 49\))Tj 5.669 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(58; 92\))Tj 5.669 0 Td (59)Tj /Span<>> BDC ( )Tj EMC (\(39; 77\))Tj 5.669 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(12; 65\))Tj /T1_2 1 Tf 5.719 0 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 414.4368 385.6993 Tm (2-3)Tj /Span<>> BDC 8 0 0 8 420.7425 383.0353 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005)Tj 4.353 0 Td (52)Tj /Span<>> BDC ( )Tj EMC (\(41; 63\))Tj -51.245 -1.433 Td (\203\036\021, \027\036 \023\030\017\n\036\027\016\033)Tj /T1_2 1 Tf 18.175 0 Td (n)Tj /T1_1 1 Tf 6.482 0 Td (17)Tj 5.919 0 Td (4)Tj 5.669 0 Td (9)Tj 5.669 0 Td (6)Tj 11.089 0 Td (36)Tj /T1_2 1 Tf -35.602 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.614 0 Td (71)Tj /Span<>> BDC ( )Tj EMC (\(51;85\))Tj 5.803 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(8; 42\))Tj 5.536 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(23;61\))Tj 5.553 0 Td (67)Tj /Span<>> BDC ( )Tj EMC (\(35; 88\))Tj 11.339 0 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(37; 59\))Tj /T1_2 1 Tf -51.245 -1.433 Td (p)Tj /T1_1 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 18.186 0 Td (p)Tj /T1_1 1 Tf 11.548 0 Td (0,004)Tj -29.734 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017)Tj /T1_2 1 Tf ( V)Tj /T1_1 1 Tf ( )Tj T* (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 18.186 1.2 Td (V)Tj /T1_1 1 Tf 9.355 0 Td (0,42)Tj /Span<>> BDC ( )Tj EMC (\(0,22; 0,61\))Tj /T1_2 1 Tf 7 0 0 7 42.5197 313.2709 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ T* (\032\020\024\033\032\027\030\027\f\027\025\022\t; \032)Tj 4.081 0 0 4.081 92.3589 307.2019 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 102.6796 304.8709 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.552 56.0378 Tm (107)Tj ET endstream endobj 942 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.139 Tw 10 0 0 10 70.8661 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\ \226\216\024\b)Tj /Span<>> BDC ( )Tj EMC 12.849 0 Td (\002\036\030\020\026\), \022\024\n\023\034\033\021\036\030\027\024\005 )Tj 0.447 Tw -12.849 -1.218 Td (\021\024\n\024\020\030\026\235\017\017 \(\022\030\017\021\036\030\017\005\ \205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\032)Tj /T1_0 1 Tf 0.541 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\ \226\216\024\b\002\036\030\020\026\). )Tj 0.117 Tw T* [(\215\030\036\017\n\031\013\036\f\021\r\036\027\027\t\005 )0.5(\r\t\002\024\030 \023\030\024\022\021\024-, \030\036\022\021\024\f\022\024\ \023\017\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.187 Tw T* (\002\035\033\007\026\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (5 \211\204\215 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f\024 \021\030\036\021\034\017\n \211\204\ \215 )Tj 0.366 Tw T* (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 5.83 0 0 5.83 245.2554 667.2699 Tm (3-5)Tj 0.366 Tw /Span<>> BDC 10 0 0 10 253.1374 663.9399 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,038 )Tj 0.105 Tw -18.227 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \). \221\024\020\007\026 \022\026\022 \235\017\002\030\024\022\024\035\024\ \027\024)Tj 0 Tw (-)Tj 0.326 Tw 0 -1.218 TD (\f\022\024\023\017\016 \002\t\035\026 \023\030\036\007\023\024\004\021\017\ \021\036\035\034\027\t\n \n\036\021\024\007\024\n \007\017\026\020\027\024\ \f)Tj 0 Tw (-)Tj 0.168 Tw 0 -1.218 TD (\021\017\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\r\036\030\021\024\n \211\204\215 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 )Tj 0.328 Tw T* (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj 5.83 0 0 5.83 244.4936 618.5578 Tm (2-4)Tj /T1_0 1 Tf 0.328 Tw /Span<>> BDC 10 0 0 10 252.0492 615.2278 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,018, )Tj /T1_1 1 Tf 0 Tw -18.118 -1.218 Td (\032)Tj 5.83 0 0 5.83 75.6461 606.3798 Tm (3-4)Tj /T1_0 1 Tf 0.024 Tw /Span<>> BDC 10 0 0 10 83.2017 603.0498 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \). \222\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.019 Tw -1.234 -1.218 Td (\027\026\017\n\036\027\034\001\026\016 \007\024\035\016 \r\t\002\024\030\ \026 \022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\ \026\235\017\017 )Tj 0.11 Tw T* [(\022\026\022 )0.5(\024\f\027\024\r\027\024\020\024 )0.5(\n\036\021\024\007\026 )0.6(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\200\002\217\215\025 )0.5(\027\026\002\035\033\007\026)]TJ 0 Tw (-)Tj 0.026 Tw T* (\035\026\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \211\204\215 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\ \226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj 5.83 0 0 5.83 75.6461 557.6678 Tm (2-3)Tj /T1_0 1 Tf 0.276 Tw /Span<>> BDC 10 0 0 10 83.2017 554.3378 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001; )Tj /T1_1 1 Tf 0 Tw (\032)Tj 5.83 0 0 5.83 133.2049 557.6678 Tm (2-4)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 0.276 Tw 10 0 0 10 143.7267 554.3378 Tm (=)Tj /Span<>> BDC ( )Tj EMC (0,006; )Tj /T1_1 1 Tf 0 Tw (\032)Tj 5.83 0 0 5.83 188.6421 557.6678 Tm (2-5)Tj /T1_0 1 Tf 0.276 Tw /Span<>> BDC 10 0 0 10 196.1977 554.3378 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 )Tj 0 Tw -12.533 -1.218 Td (\207\024\027\235\036\030\030\024\027\017\).)Tj -0.025 Tw T* [(\210\007\017\027 )0.5(\030\036\f\023\024\027\007\036\027\021 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 7.91 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\017\n )0.5(\f\021\026\032\036\n )0.5(20 )0.5(\035\036\021 )0.6(\f\004\036\035 )]TJ 0.265 Tw -7.91 -1.218 Td (\r\024\n\024\032\027\t\n \023\030\017\n\036\027\036\027\017\036 \n\026\020\ \027\017\021\027\024-\030\036\024\027\026\027\f\027\024\005 \021\024)Tj 0 Tw (-)Tj 0.138 Tw T* (\n\024\020\030\026\235\017\017 \007\035\016 \007\017\026\020\027\024\f\021\ \017\022\017 \200\002\217\215\025, \027\036\f\n\024\021\030\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.017 Tw T* (\f\024\022\031\033 \030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\ \f\021\034 \235\036\030\030\024\n\026\020\027\017\021\027\t\b \017\027\024\ \030\024\007)Tj 0 Tw (-)Tj T* (\027\t\b \021\036\035.)Tj /T1_2 1 Tf 0.222 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2362)Tj /T1_0 1 Tf (: \253\025\026\022\024\005 \f\023\024\f\024\002 \235\024\030\n\017\030\024\ \r\026\027\017\016 \007\017\r\036\030)Tj 0 Tw (-)Tj 0.678 Tw 0 -1.218 TD (\f\017\024\027\027\024\005 \022\024\035\024\f\021\024\n\t \016\r\035\016\ \036\021\f\016 \023\030\036\007\023\024\004\021\017\021\036\035\034\027\t\ \n )Tj 0.268 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\024\n \(\007\024 \274 \024\ \022\030\031\032\027\024\f\021\017\) \r\027\036\002\030\033)Tj 0 Tw (-)Tj T* (\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\016\n\024\005\ \022\017\001\022\017?\273)Tj 0.516 Tw T* (\200\t\002\024\030 \n\036\021\024\007\024\r \235\024\030\n\017\030\024\r\ \026\027\017\016 \022\024\035\024\f\021\024\n\t \f\030\036\007\017 )Tj 0.15 Tw T* (\r\f\036\b \020\030\031\023\023 \211\204\215 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \024\021\035\017\004\026\035\f\016 \(\022\030\017\021\ \036\030\017\005 )Tj 0 Tw T* (\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_1 1 Tf 12.112 0 Td (\032)Tj /T1_0 1 Tf 0.352 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0032\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\), )Tj 0.093 Tw -12.112 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\004\017\n\024 \n\036\027\034\001\036 \b\017\030\ \031\030\020\017-\030\036\f\023\024\027\007\036\027\021\t \r\t)Tj 0 Tw (-)Tj 0.051 Tw T* (\023\024\035\027\016\035\017 \024\007\027\024\f\021\r\024\035\034\027\031\ \033 \022\024\035\024\f\021\024\n\017\033)Tj /Span<>> BDC ( )Tj EMC (\227 12 \(6; 22\) % )Tj 0.129 Tw 23.244 36.534 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC 2.494 0 Td [(1\). \216\017\030\031\030\020\017\004\036\f\022\017\005 \f\021\026\032 )0.5(\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 )0.5(\030\036)]TJ 0 Tw (-)Tj -2.494 -1.218 Td (\f\023\024\027\007\036\027\021\024\r \f\024\f\021\026\r\017\035)Tj /Span<>> BDC ( )Tj EMC (\227 16 \(12; 19\) \035\036\021.)Tj 0.569 Tw T* (\200\t\002\024\030 \007\r\031\f\021\r\024\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\f\021\r\024\035\034\027\024\005 \022\024\035\024\f\021\024\ \n )Tj 0.442 Tw 0 -1.218 TD (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \030\ \026\035\017\004\026\035\f\016 \f\030\036\007\017 \030\026\027\t\b )Tj 0.157 Tw 0 -1.218 TD [(\031\030\024\r\027\036\005 )0.5(\211\204\215 )0.6(\(\022\030\017\021\036\030\017\005 )0.5(\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )]TJ /T1_1 1 Tf 0 Tw 0 -1.218 TD (\032)Tj /T1_0 1 Tf 0.277 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035 \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.277 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,003 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\ \226)Tj 0.372 Tw 0 -1.218 TD (\216\024\b\002\036\030\020\026\). \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \007\r\031\b\f\021\r\024\035\034\027\031\ \033 \022\024\035\024\f\021\024\n\031 )Tj 0.339 Tw 0 -1.218 TD (\f\021\026\021\017\f\021\017\004\036\f\022\017 \n\036\027\034\001\036 \235\ \024\030\n\017\030\031\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (4 \211\204\215, \004\036\n )Tj 0.116 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\ \226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj /T1_0 1 Tf 5.83 0 0 5.83 308.087 618.5578 Tm (2-4)Tj 0.174 Tw /Span<>> BDC 10 0 0 10 315.9691 615.2278 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,034; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 5.83 0 0 5.83 362.9075 618.5578 Tm (3-4)Tj 0.174 Tw /Span<>> BDC 10 0 0 10 370.7896 615.2278 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,049 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \), )Tj -0.018 Tw -6.748 -1.218 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \023\030\036\007\023\024\004\021\036\027\017\016 \024\007\ \027\024\f\021\r\024\035\034\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 36 \(15; 34\))Tj /Span<>> BDC ( )Tj EMC 21.351 0 Td (% )Tj 0 Tw -21.351 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj /T1_2 1 Tf 0.098 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2363:)Tj /T1_0 1 Tf ( \253\215\030\017\n\036\027\016\036\021\036 \035\017 \200\t \021\030\026\ \027\f\035\033\n\017\027\026\035\034\027\024\036 )Tj 0.076 Tw 0 -1.218 TD (\031\001\017\r\026\027\017\036 \007\036\235\036\022\021\026 \023\030\016\ \n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj -0.014 Tw T* (\027\024\n \(\007\024 \274 \024\022\030\031\032\027\024\f\021\017\) \r\027\ \036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\ \030\016)Tj 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017?\273)Tj 0.187 Tw T* [(\222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\ \r \f\024\024\021\027\024\001\036\027\017\036, )0.5(\017\f\023\024\035\034\031\033)]TJ 0 Tw (-)Tj -0.079 Tw T* (\013\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \017\f\023\024\035\034\031\033\013\017\b, \021\030\026\027\f\035\ \033\n\017\027\026\035\034\027\024\036 \031\001\017\r\026\027\017\036 )Tj 0.193 Tw T* (\030\026\027 \023\030\016\n\024\005 \022\017\001\022\017 \027\036 \024\021\ \035\017\004\026\035\024\f\034 \024\021 \030\026\r\027\024\n\036\030\027\ \024\020\024 )Tj 0.106 Tw T* (\002\017\027\024\n\017\027\026\035\034\027\024\020\024 \030\026\f\023\030\ \036\007\036\035\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\036\n\024\005 \007\024\035\036\005 )Tj 0.051 Tw T* (50% \(\022\030\017\021\036\030\017\005 \f\024\020\035\026\f\017\016 )Tj /T1_1 1 Tf 0 Tw (\250)Tj 5.83 0 0 5.83 413.9756 472.4218 Tm (2\032)Tj 0.051 Tw /Span<>> BDC 10 0 0 10 419.6773 469.0918 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf (0,729\). \210\007\027\026\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj -0.098 Tw -11.637 -1.218 Td (\027\t\b \211\204\215 \027\026\002\035\033\007\026\035\017\f\034 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\036 \030\026\ \035\017)Tj 0 Tw (-)Tj 0.218 Tw T* [(\004\017\016 )0.5(\004\026\f\021\024\021\t )0.5(\r\t\023\024\035\027\036\027\017\016 )0.5(\b\017\030\031\030\020\026\n\017-\030\036\f\023\024\027\007\036\027\021\026\ \n\017 )]TJ 0.085 Tw T* (\021\030\026\027\f\035\033\n\017\027\026\035\034\027\024\020\024 \031\001\ \017\r\026\027\017\016 \007\036\235\036\022\021\026 \023\030\016\n\024\005\ \022\017\001)Tj 0 Tw (-)Tj 0.075 Tw T* (\022\017 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\ \205\030\017\n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\). )Tj 0.139 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \b\017\030\031\030\020\017 2 \211\204\215 \030\036\032\036\ \r\t\023\024\035\027\016\035\017 \021\030\026\027\f\035\033)Tj 0 Tw (-)Tj 0.198 Tw T* [(\n\017\027\026\035\034\027\024\036 )0.6(\031\001\017\r\026\027\017\036 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 17.552 0 Td (\f\030\026\r\027\036\027\017\033 )Tj -0.032 Tw -17.552 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\f\023\024\027\007\036\027\021\026\n\017 3 \211\204\215, \020\007\ \036 \007\026\027\027\t\005 \023\024\007\b\024\007 \002\t\035 \023\030\036\ \007)Tj 0 Tw (-)Tj 0.026 Tw T* (\023\024\004\021\017\021\036\035\034\027\t\n \(\022\030\017\021\036\030\017\ \005 \205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\ \021\024\027\026, )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.178 Tw T* [(\217\036\f\023\024\027\007\036\027\021\t, )0.6(\023\030\036\007\023\024\004\017\021\026\033\013\017\036 )0.5(\r\t\023\024\035\027\016\021\034 )0.6(\021\030\026\027\f\035\033)]TJ 0 Tw (-)Tj -0.023 Tw T* (\n\017\027\026\035\034\027\024\036 \031\001\017\r\026\027\017\036 \200\002\ \217\215\025, \027\036 \024\021\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tw (-)Tj 0.098 Tw T* (\020\017\004\036\f\022\024\n\031 \f\021\026\032\031 \024\021 \030\036\f\023\ \024\027\007\036\027\021\024\r, \027\036 \023\030\026\022\021\017\022\031\ \033\013\017\b )Tj 0 Tw T* (\031\001\017\r\026\027\017\036 \()Tj /T1_1 1 Tf (t )Tj /T1_0 1 Tf (\022\030\017\021\036\030\017\005 \222\021\034\033\007\036\027\021\026, )Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\).)Tj /T1_2 1 Tf 0.152 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2364:)Tj /T1_0 1 Tf ( \253\025\026\022\017\n \f\023\024\f\024\002\024\n \200\t \r\t\023\024\035\ \027\016\036\021\036 \007\017\f)Tj 0 Tw (-)Tj 0.057 Tw 0 -1.218 TD [(\021\026\035\034\027\024\036 )0.6(\024\021\n\t\r\026\027\017\036 )0.5(\024\021\022\035\033\004\036\027\027\024\005 )0.6(\004\026\f\021\017 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001)]TJ 0 Tw (-)Tj T* (\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017\ \023\030\016\n\024\005 \022\017\001\022\017?\273)Tj 0.004 Tc 0.264 Tw T* [(\222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\ \r \002\024\035\034\001\026\016 \004\026\f\021\034 \024\021\007\026\r\026\ \035\026)4( )]TJ 0.094 Tw T* [(\023\030\036\007\023\024\004\021\036\027\017\036 \024\021\n\t\r\026\027\017\ \033 \004\036\030\036 \f\021\024\n\031 \024\021\022\035\033\004\036\027\ \027\024\005)4( )]TJ 0.077 Tw T* (\004\026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 47 \(35; 59\) %. \200\t\002\024\030 \n\036\021\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.248 Tw T* [(\007\024\r \024\021\n\t\r\026\027\017\016 \024\021\022\035\033\004\036\027\ \027\024\005 \004\026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\ \017)4( )]TJ 0.23 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \030\ \026\035\017\004\026\035\f\016 \f\030\036\007\017 \017\f\f\035\036\007\031\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.542 Tw T* [(\036\n\t\b )0.5(\211\204\215 )0.6(\(\022\030\017\021\036\030\017\005 )0.5(\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026,)4( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (p)Tj /T1_0 1 Tf 0.004 Tc /Span<>> BDC 0.482 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,3\26710)Tj -0.004 Tw 5.83 0 0 5.83 342.3966 180.1498 Tm (-4)Tj 10 0 0 10 347.4104 176.8198 Tm (\).)Tj 0 Tc 0.22 Tw -4.41 -1.218 Td (\200 \004\026\f\021\027\024\f\021\017, \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 \f\021\026\021\017\f\021\017\004\036\f\022\017 \030\036\032\ \036 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.182 Tw T* 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\221\026\022\032\036 \f\021\026\021\017\f\021\017\004\036)Tj 0 Tw (-)Tj -0.036 Tw T* (\f\022\017\036 \027\026\004\017\n\t\036 \030\026\035\017\004\017\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \211\204\215 \027\026\002\035\033\007\026\035\017\f\034\ )Tj 0.093 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \r\027\031\021\030\017\023\030\024\f\r\036\021\027\t\ \b \n\036\021\024\007\024\r \007\017\026\020\027\024\f\021\017\022\017 )Tj 0.139 Tw 23.244 3.653 Td (\023\024\r\030\036\032\007\036\027\017\005 \023\030\016\n\024\005 \022\017\ \001\022\017 \(\023\030\024\022\021\024-, \030\036\022\021\024\f\022\024\ \023\017\016\) )Tj -0.001 Tw T* (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf -0.001 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,014 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.226 Tw T* (\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\226\216\024\ \b\002\036\030\020\026\) \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\024\022\024\035\024\027\024\f\022\024)Tj 0 Tw (-)Tj 0.097 Tw T* [(\023\017\017 )0.5(\(\022\030\017\021\036\030\017\005 )0.6(\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )]TJ /T1_2 1 Tf 0 Tw 18.288 0 Td (\032)Tj /T1_1 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC 0.807 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.829 0 Td (0,005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.047 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \003\025\020\f\022\016 \021\025\r\023\032\027\025\025\027\235 \024\031\b\ \f\020\024\031\021\020\025\025\031\024\023\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\n\031\204\203\203\022\006\022\027\025\023\r \003\2051 \216\021\027\023\020\ \021)Tj /Span<>> BDC ( )Tj EMC (\030\022\020\b\025\031\024\023\022\n\027 \022)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\031\235 \023\020\n\023\022\n\027 \ )Tj 0.039 Tw 0 -1.2 TD (\f\027\007\027\025\022\t \021\025\027\240\032\005\213\022\025\025\013\200\ \032\020\025\027\025\022\235 \033\032\t\026\031\235 \n\022\213\n\022 \026\ \027\255\030\r \b\032\r\033\033\020\026\022 \032\027\024\033\031\025\030\ \027\025\023\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025)Tj 0 Tw (-)Tj T* (\024\n\031\235 \033\031\026\031\212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.002 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.025 Tw 3.293 0 Td [( )0.5(Ana)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 4.625 0 Td [(i)3.9(n)-0.6(t)-1.6(e)-6(r)-18.6(na)-4.4(l c)2.9(o)-4(n)3.7(s)-12.5(i)6.6(s)-14.8(t)-1.6(e)-7(n)-2.9(c)-32.4(y )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 9.059 0 Td [(d)-3(i)1.5(a)-5.2(g)-2.4(n)-2.4(o)-1.1(s)-14.7(t)-29.1(i)-1.8(c)-26.7(s )0.5(a)-5.1(n)-4.8(d )0.5(s)6.7(u)1.6(r)-2(g)-18.7(i)-1.8(c)3.2(a)-4.5(l )0.5(t)-1.9(a)-9.2(c)-32.4(t)-29.1(i)-1.8(c)-26.7(s )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 13.516 0 Td [(t)-9.6(r)-2(e)-7.5(a)-9.2(t)-10.6(m)-5.2(e)-7(n)-0.6(t )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 5.162 0 Td [(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.3(e)-6(r)-38.9(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l )0.5(w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.8(s )0.5(o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC 10.492 0 Td [(t)-10.6(h)-2.4(e )0.5(r)-2(e)-10.9(c)-32.4(t)-1.1(u)0.7(m )]TJ 0 Tw -46.146 -1.2 Td [(b)-10.1(e)-8.6(t)-22.9(w)2.2(e)-10.4(e)-6.9(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-1.9(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(n)-0.6(t)-32.9(s a)-9.1(t d)-3(i)5.1(f)-42.4(f)-13.4(e)-6(r)-2(e)-6.9(n)-0.6(t le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-3(i)-1.8(c)3.2(a)-4.5(l c)3.3(a)-4.2(r)-2(e w)-26.7(i)-3.4(t)-10.5(h t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(G)2.5(w)2.2(e)-8.6(t)-35.2(\222)25.1(s a)-5.2(g)-1.5(r)-2(e)-10.4(e)-7(m)-5.3(e)-7(n)-0.6(t c)2.8(o)-11.9(ef)-40.6(\243)-1.2(c)-30.1(i)-1.4(e)-7(n)-0.6(t A)10.5(C)18.7(1)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 682.7811 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 292.2185 682.7811 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 348.9114 682.7811 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 405.6044 682.7811 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 462.2972 682.7811 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 652.1119 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 652.1119 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 652.1119 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 652.1119 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 652.1119 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 631.0505 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 631.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 631.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 631.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 631.0505 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 609.9893 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 609.9893 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 609.9893 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 609.9893 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 609.9893 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 588.928 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 588.928 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 588.928 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 588.928 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 588.928 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 577.4667 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 577.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 577.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 577.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 577.4667 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.0054 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 566.0054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 566.0054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 566.0054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 566.0054 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 544.9442 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 544.9442 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 544.9442 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 544.9442 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 544.9442 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 523.8829 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 523.8829 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 523.8829 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 523.8829 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 523.8829 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 502.8216 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 502.8216 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 502.8216 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 502.8216 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 502.8216 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 491.3603 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 491.3603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 491.3603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 491.3603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 491.3603 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 470.299 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 292.2185 470.299 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 470.299 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 470.299 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 462.2972 470.299 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 85.4071 664.5466 Tm (\231\f\r\214\r\b\003 \240\t\004\n\b\002\217\003\t\220\t \t)Tj /Span<>> BDC ( )Tj EMC (\216\t\006\210\006\n\t\201\r\217\220\002\005 \003\004\220\003\t\220\t)Tj 26.873 1.2 Td (\021\002\f\t\201\r\217\003\002 )Tj -0.52 -1.2 Td (\006\r\217\212\002\b\240\r\b\003\002 )Tj 0.749 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\013\206\002\006\220\r)Tj 6.348 1.8 Td (\021\002\234\226\226\t\204\t\r\b\003 )Tj /T1_4 1 Tf 2.23 -1.2 Td (\026\0301)Tj /T1_3 1 Tf 5.276 1.2 Td (95% \031\034 \240\f\235 )Tj /T1_4 1 Tf 1.81 -1.2 Td (AC1)Tj 6.212 0.601 Td (\t)Tj /T1_1 1 Tf -53.953 -2.633 Td (\222\023\024\f\024\002 \235\024\030\n\017\030\024\r\026\027\017\016 \007\ \017\r\036\030\f\017\024\027\027\024\005 \022\024\035\024\f\021\024\n\t \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b )Tj T* (\200\002\217\215\025)Tj 33.87 1.2 Td (75)Tj 6.244 0 Td (\2440,069)Tj 5.602 0 Td (\(\2440,17; 0,031\))Tj 7.654 0 Td (0,91)Tj -53.37 -2.633 Td (\215\030\017\n\036\027\036\027\017\036 \021\030\026\027\f\035\033\n\017\027\ \026\035\034\027\024\020\024 \031\001\017\r\026\027\017\016 \007\036\235\ \036\022\021\026 \023\030\016\n\024\005 \022\017\001\022\017 )Tj T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b \200\002\217\215\025\ )Tj 33.87 1.2 Td (75)Tj 6.244 0 Td (\2440,074)Tj 5.852 0 Td (\(\2440,32; 0,17\))Tj 7.404 0 Td (0,73)Tj -53.37 -2.633 Td (\222\023\024\f\024\002 \007\017\f\021\026\035\034\027\024\020\024 \024\021\ \n\t\r\026\027\017\016 \024\021\022\035\033\004\036\027\027\024\005 \004\ \026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0 -1.2 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (75)Tj 6.494 0 Td (0,044)Tj 5.602 0 Td (\(\2440,07; 0,56\))Tj 7.404 0 Td (0,21)Tj -53.37 -2.633 Td (\200\t\023\024\035\027\036\027\017\036 \007\017\r\031\035\034\f\017\017 \ \f\235\017\027\022\021\036\030\026 \023\030\016\n\024\005 \022\017\001\022\ \017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 0 Td (75)Tj 6.744 0 Td (0,17)Tj 5.352 0 Td (\(\2440,14; 0,48\))Tj 7.404 0 Td (0,13)Tj -53.37 -1.433 Td (\210\f\027\024\r\027\024\005 \023\030\017\n\036\027\016\036\n\t\005 \n\036\ \021\024\007 \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\ \025)Tj 33.87 0 Td (75)Tj 6.494 0 Td (0,081)Tj 5.602 0 Td (\(\2440,01; 0,18\))Tj 7.404 0 Td (0,04)Tj -53.37 -1.433 Td (\206\035\031\002\017\027\026 \031\f\021\026\027\024\r\022\017 \023\026\030\ \026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\027\026\032\ \026 \023\030\024\n\036\032\027\024\f\021\027\t\n \007\024\f\021\031\023\ \024\n )Tj T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (48)Tj 6.494 0 Td (0,082)Tj 5.602 0 Td (\(\2440,01; 0,17\))Tj 6.904 0 Td (0,0037)Tj -52.87 -2.633 Td (\210\030\017\036\027\021\017\030 \007\035\016 \022\024\027\021\030\024\035\ \016 \020\035\031\002\017\027\t \031\f\021\026\027\024\r\022\017 \023\026\ \030\026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\027\026\ \032\026 )Tj T* (\023\030\024\n\036\032\027\024\f\021\027\t\n \007\024\f\021\031\023\024\n\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (42)Tj 6.744 0 Td (0,16)Tj 5.352 0 Td (\(0,072; 0,24\))Tj 6.785 0 Td (3,9\26710)Tj /Span<>> BDC 4.664 0 0 4.664 487.0183 538.9816 Tm (-)Tj EMC (4)Tj 8 0 0 8 45.6044 515.2563 Tm (\211\f\021\026\027\024\r\022\026 \023\026\030\026\030\036\022\021\026\035\ \034\027\t\b \007\030\036\027\026\032\036\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017\035\017 \023\024\f\035\036 \031\001\017\r\026\027\017\016 )Tj 0 -1.2 TD (\035\026\023\026\030\024\021\024\n\027\024\005 \030\026\027\t \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (67)Tj 6.744 0 Td (0,38)Tj 5.602 0 Td (\(0,12; 0,65\))Tj 6.654 0 Td (0,0032)Tj -52.87 -2.633 Td (\037\036\035\034 \030\031\021\017\027\027\024\020\024 \023\026\030\026\030\ \036\022\021\026\035\034\027\024\020\024 \007\030\036\027\017\030\024\r\026\ \027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 0 Td (75)Tj 6.744 0 Td (0,45)Tj 5.602 0 Td (\(0,22; 0,63\))Tj 6.535 0 Td (1,4\26710)Tj /Span<>> BDC 4.664 0 0 4.664 487.0183 496.859 Tm (-)Tj EMC (4)Tj 8 0 0 8 45.6044 482.7337 Tm (\222\023\024\f\024\002 \007\030\036\027\017\030\024\r\026\027\017\016 \022\ \035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\ \021\r \021\026\026 \023\030\024\n\036\032\027\024\f\021\027\t\n )Tj T* (\007\024\f\021\031\023\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (75)Tj 6.744 0 Td (0,46)Tj 5.602 0 Td (\(0,23; 0,69\))Tj 6.535 0 Td (2,3\26710)Tj /Span<>> BDC 4.664 0 0 4.664 487.0183 485.3977 Tm (-)Tj EMC (4)Tj /T1_2 1 Tf 7 0 0 7 42.5197 458.8144 Tm [(\004\032\022\026\027\007\020\025\022\027: \021\027\032\240\020\f\017\025\ \020\t \213\n\020\f\020 \030\f\t \n\031\204\203\203\022\006\022\027\025\023\ \020 \024\031\b)28.5(\f\020\024\031\021\020\025\025\031\024\023\022 \003)48.1(\2051 \(Gw)12(et K., 2014\): 0,0\2310,4)]TJ /Span<>> BDC ( )Tj EMC (\227 \025\022\016\n\020\t \024\023\027\033\027\025\017; 0,4\2310,8)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\t\t \024\023\027\033\027\025\017; 0,8\2311,0)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj T* (\021\013\024\031\n\020\t \024\023\027\033\027\025\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.01 Tc 9 0 0 9 42.5197 431.1105 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\032\022\026\027\025\027\025\022\027 \032\027\024\033\031\025\030\027\ \025\023\020\026\022 \026\027\023\031\030\031\021 \030\022\020\b\025\031\ \024\023\022\n\022 \211\240\206\004\202 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\ \212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( R)2.8(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.2(e)-7(n)-0.6(t)-32.9(s u)-4.4(s)0.5(e o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-3(i)1.5(a)-5.2(g)-2.4(n)-2.4(o)-1.1(s)-14.8(t)-29.1(i)-1.8(c m)-5.2(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.8(s f)-13.3(o)-3(r e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.3(e)-5.9(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l r)-2(e)-10.8(c)-32.4(t)-2(a)-4.5(l w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.7(s a)-9.2(t v)6.3(a)-4.2(r)-39(i)-1.4(o)-3.3(u)-4.4(s le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-3(i)-1.8(c)3.2(a)-4.5(l c)3.2(a)-4.2(r)-2(e)]TJ ET /GS2 gs q 1 0 0 1 42.5197 415.8085 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 415.8085 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 215.6831 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 261.0374 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 306.3918 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 415.8085 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9587 415.8085 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 404.3393 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 404.3393 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 215.6831 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 261.0374 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 306.3918 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 404.3393 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9587 404.3393 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 392.8701 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 381.4088 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 392.8701 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 392.8701 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 392.8701 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 352.8588 cm 0 0 m 0 28.55 l S Q q 1 0 0 1 158.7402 381.4088 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 215.6831 381.4088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 261.0374 381.4088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 306.3918 381.4088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 351.7461 381.4088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 397.1004 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 450.7087 381.4088 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 496.313 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 42.5197 352.6088 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 341.1475 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 352.6088 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 352.6088 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 352.6088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 329.9362 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 341.1475 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 341.1475 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 341.1475 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 341.1475 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 341.1475 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 341.1475 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 329.6862 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 318.2249 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 329.6862 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 329.6862 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 329.6862 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 307.0136 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 318.2249 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 318.2249 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 318.2249 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 318.2249 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 318.2249 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 318.2249 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 306.7636 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 295.3024 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 306.7636 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 306.7636 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 306.7636 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 266.7524 cm 0 0 m 0 28.55 l S Q q 1 0 0 1 158.7402 295.3024 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 215.6831 295.3024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 261.0374 295.3024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 306.3918 295.3024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 351.7461 295.3024 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 397.1004 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 450.7087 295.3024 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 496.313 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 42.5197 266.5024 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 255.0411 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 266.5024 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 266.5024 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 266.5024 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 243.8298 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 255.0411 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 255.0411 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 255.0411 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 255.0411 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 255.0411 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 255.0411 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 243.5798 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 232.1185 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 243.5798 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 243.5798 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 243.5798 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 213.1685 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 158.7402 232.1185 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 215.6831 232.1185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 261.0374 232.1185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 306.3918 232.1185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 351.7461 232.1185 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 397.1004 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 450.7087 232.1185 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 496.313 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 42.5197 212.9185 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 201.4572 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 212.9185 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 212.9185 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 212.9185 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 190.2459 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 201.4572 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 201.4572 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 201.4572 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 201.4572 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 201.4572 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 201.4572 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 189.9959 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 158.9902 189.9959 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 397.1004 189.9959 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 189.9959 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 178.5347 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 158.9902 178.5347 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 215.6831 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 261.0374 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 397.1004 178.5347 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9587 178.5347 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 157.4734 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 158.9902 157.4734 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 215.6831 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 397.1004 157.4734 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 450.9587 157.4734 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 67.3123 407.174 Tm (\215\r\003\002\240 \240\t\004\n\b\002\217\003\t\220\t)Tj 13.024 0 Td (\255\t\214\002\f\013)Tj 6.168 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 8.13 0.001 Td (\t)Tj /T1_3 1 Tf 5.017 -0.001 Td (\017\206\227\r\r)Tj /T1_1 1 Tf -52.061 -1.433 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 17.404 0 Td (N)Tj /T1_3 1 Tf 6.134 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_4 1 Tf 6.201 0.001 Td (\226)Tj /T1_3 1 Tf 5.923 -0.001 Td (75)Tj /T1_1 1 Tf -52.948 -1.433 Td (\215\026\035\034\006\036\r\024\036 \030\036\022\021\026\035\034\027\024\036\ )Tj T* (\017\f\f\035\036\007\024\r\026\027\017\036)Tj /T1_2 1 Tf 17.467 1.2 Td (n)Tj /T1_1 1 Tf 6.128 0 Td (18)Tj 5.919 0 Td (8)Tj 5.669 0 Td (1)Tj 5.669 0 Td (0)Tj 5.452 0 Td (10)Tj 4.664 0 0 4.664 424.0427 386.9075 Tm (-6)Tj 8 0 0 8 428.0164 384.2435 Tm (*)Tj /T1_2 1 Tf -2.422 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 412.4622 377.3075 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 418.7679 374.6435 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 434.4957 377.3075 Tm (\2265)Tj /T1_2 1 Tf 8 0 0 8 408.6382 365.0435 Tm (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 412.4622 367.7075 Tm (2-5)Tj /Span<>> BDC 8 0 0 8 418.7679 365.0435 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 434.4957 367.7075 Tm (\2263)Tj /T1_2 1 Tf 8 0 0 8 406.7495 355.4435 Tm (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.5734 358.1075 Tm (3-4)Tj /Span<>> BDC ( )Tj EMC 8 0 0 8 417.9658 355.4435 Tm (=)Tj /Span<>> BDC ( )Tj EMC (0,031)Tj 6.459 3.6 Td (27)Tj /T1_2 1 Tf -38.369 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.201 0 Td (78)Tj /Span<>> BDC ( )Tj EMC (\(50; 95\))Tj 5.669 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(15; 69\))Tj 6.169 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 29\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 11.902 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(25; 48\))Tj -51.245 -3.6 Td (\217\036\027\021\020\036\027\024\020\030\026\235\017\016)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (3)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.358 0 Td (0,15*)Tj 7.043 0 Td (3)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.201 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(17; 40\))Tj 6.169 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 22\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 12.059 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0,8; 11\))Tj -51.403 -1.433 Td (\215\030\024\022\021\024-, \030\036\022\021\024\f\022\024\023\017\016, \024\ \f\n\024\021\030 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026\035\026\b)Tj /T1_2 1 Tf 17.467 1.2 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (1)Tj 5.669 0 Td (0)Tj 5.669 0 Td (5)Tj 5.669 0 Td (3)Tj 5.108 0 Td (0,014*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 314.1236 Tm (3-5)Tj /Span<>> BDC 8 0 0 8 416.4905 311.4596 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,038)Tj 6.893 1.2 Td (9)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 28\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.419 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(6; 53\))Tj 5.669 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(5; 77\))Tj 12.402 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(5; 22\))Tj -51.495 -1.433 Td (\025\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\026\ \235\017\016)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (1)Tj 5.419 0 Td (11)Tj 5.669 0 Td (10)Tj 5.919 0 Td (5)Tj 5.108 0 Td (0,001*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 291.201 Tm (2-3)Tj /Span<>> BDC 8 0 0 8 416.4905 288.537 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 281.601 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 416.4905 278.937 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 272.001 Tm (2-5)Tj /Span<>> BDC 8 0 0 8 416.4905 269.337 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004)Tj 6.643 3.6 Td (27)Tj /T1_2 1 Tf -38.369 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.818 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0;28\))Tj 5.053 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(25; 81\))Tj 5.669 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(20; 73\))Tj 5.669 0 Td (56)Tj /Span<>> BDC ( )Tj EMC (\(16; 90\))Tj 12.402 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(25; 48\))Tj -51.245 -3.6 Td (FAST-\023\030\024\021\024\022\024\035)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (1)Tj 5.669 0 Td (1)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.358 0 Td (0,81*)Tj /T1_2 1 Tf -1.116 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 250.9398 Tm (3-5)Tj /Span<>> BDC 8 0 0 8 416.4905 248.2758 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,038)Tj 6.893 1.2 Td (2)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 28\))Tj 5.669 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(0; 32\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 22\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 12.309 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(0,3; 9\))Tj -51.653 -1.433 Td (\205\017\002\030\024\022\024\035\024\027\024\f\022\024\023\017\016)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (6)Tj 5.669 0 Td (0)Tj 5.108 0 Td (0,005*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 228.0172 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 416.4905 225.3532 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,018)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 218.4172 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 416.4905 215.7532 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035)Tj 6.893 2.4 Td (6)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.419 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(8; 58\))Tj 5.919 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 12.402 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(2; 17\))Tj -51.745 -2.4 Td (\204\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ )Tj T* (\021\024\n\024\020\030\026\235\017\016)Tj /T1_2 1 Tf 17.467 1.2 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (1)Tj 5.358 0 Td (0,15*)Tj 7.043 0 Td (1)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 22\))Tj 5.419 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(0; 57\))Tj 12.902 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(0; 7\))Tj /T1_2 1 Tf -51.995 -1.433 Td (p)Tj /T1_1 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 17.478 0 Td (p)Tj /T1_1 1 Tf 13.179 0 Td (1,6 \b 10)Tj 4.664 0 0 4.664 315.6187 184.0333 Tm (-10)Tj 8 0 0 8 421.8055 181.3693 Tm (\226)Tj 6.201 0 Td (\226)Tj -53.226 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_2 1 Tf (V)Tj /T1_1 1 Tf ( )Tj T* (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 17.477 1.2 Td (V)Tj /T1_1 1 Tf 11.835 0 Td (0,55)Tj /Span<>> BDC ( )Tj EMC (\(0,37; 0,69\))Tj 17.713 0 Td (\226)Tj 6.201 0 Td (\226)Tj /T1_2 1 Tf 7 0 0 7 42.5197 145.9888 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ 0 -1.2 TD (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020; \032)Tj 4.081 0 0 4.081 303.4887 139.9198 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 313.8094 137.5888 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.4397 56.0378 Tm (105)Tj ET endstream endobj 962 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.134 Tw 10 0 0 10 70.8661 603.0499 Tm (\212\035\016 \n\036\030\027\t\b \007\026\027\027\t\b \030\026\f\f\004\017\ \021\t\r\026\035\017 95% \007\024\r\036\030\017\021\036\035\034)Tj 0 Tw (-)Tj 0.366 Tw 0 -1.218 TD (\027\t\036 \017\027\021\036\030\r\026\035\t \(\212\230\) \027\036\023\026\ \030\026\n\036\021\030\017\004\036\f\022\017\n \n\036\021\024\007\024\n \ )Tj 0.348 Tw T* (\030\036\f\026\n\023\035\017\027\020\026 \(\002\031\021\f\021\030\036\023\ \). \221\024\004\027\t\036 95% \007\024\r\036\030\017\021\036\035\034)Tj 0 Tw (-)Tj 0.135 Tw 0 -1.218 TD (\027\t\036 \017\027\021\036\030\r\026\035\t \007\035\016 \r\t\002\024\030\ \024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\002\017\027\024\n\017\027\026\035\034\027\t\n \030\026\f)Tj 0 Tw (-)Tj 0.375 Tw 0 -1.218 TD (\023\030\036\007\036\035\036\027\017\036\n \r\036\030\024\016\021\027\024\ \f\021\036\005 \030\026\f\f\004\017\021\t\r\026\035\017 \n\036\021\024\007\ \024\n )Tj 0.075 Tw 0 -1.218 TD (\025\035\024\023\023\036\030\026\226\215\017\030\f\024\027\026. \212\035\ \016 \023\030\024\r\036\030\022\017 \020\017\023\024\021\036 \023\030\017\ \n\036\027\016)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD [(\035\017 \030\026\027\007\024\n\017\026\006\017\024\027\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\036\f\021\026\027\024\r\024\004\027\t\036 \023\030\024\006\036\ \007\031)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\t \204\024\027\021\036-\025\026\030\035\024.)Tj 0.336 Tw 0 -1.218 TD (\212\035\016 \026\027\026\035\017\026 \021\026\002\035\017\006 \f\024\023\ \030\016\032\036\027\027\024\f\021\017 \017\f\023\024\035\034\024\r\026\ \035\017 )Tj 0.214 Tw 0 -1.218 TD (\021\024\004\027\t\005 \022\030\017\021\036\030\017\005 \205\017\001\036\ \030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\026. \ \200)Tj /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tw (-)Tj 0.244 Tw T* (\004\036\f\021\r\036 \n\036\030\t \f\r\016\017 \017\035\017 \027\036\024\ \007\027\024\030\024\007\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \017\f)Tj 0 Tw (-)Tj 0.018 Tw 0 -1.218 TD [(\023\024\035\034\024\r\026\035\017 \022\024\220\235\235\017\006\017\036\ \027\021 )0.5(\f\024\023\030\016\032\036\027\027\024\f\021\017 )]TJ /T1_1 1 Tf 0 Tw 17.558 0 Td (V)Tj /T1_0 1 Tf 0.018 Tw ( \025\030\026\n\036\030\026. )Tj -0.014 Tw -17.558 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \n\036\030\t \f\024\020\035\026\f\017\016 \n\ \036\032\007\031 \007\r\031\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \024\006\036\027)Tj 0 Tw (-)Tj 0.475 Tw 0 -1.218 TD (\013\017\022\026\n\017 \017\f\023\024\035\034\024\r\026\035\017 \022\024\ \220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\027\024\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\017 )Tj /T1_1 1 Tf 1.73 0 Td (\003\2051 )Tj /T1_0 1 Tf 0.162 Tw 1.868 0 Td [(\206\r\036\021\026, \r\t\004\017\f\035\016\036\n\t\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(\023\030\024\020\030\026\n\n\t )]TJ 0.383 Tw -3.597 -1.218 Td [(A)-25(gr)-24(eeS)15.1(t)15(a)15(t \(ht)-30(tps://a)-17(gr)-24(eest)15(a)15(t360.com/; 06.08.2025\). )]TJ 0.369 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \007\024\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\026\b \f\024\023\030\016\032\036\027\027\024\f\021\ \017 )Tj 0.102 Tw 0 -1.218 TD [(\023\030\017\n\036\027\016\035\017 \023\024\023\030\026\r\022\031 )0.5(\007\035\016 \n\027\024\032\036\f\021\r\036\027\027\t\b \f\030\026\r\027\ \036\027\017\005 )]TJ 0.128 Tw 0 -1.218 TD [(\207\024\027\235\036\030\030\024\027\017 )0.6(\(\023\030\017 )0.5(\023\024\023\026\030\027\024\n )0.6(\f\030\026\r\027\036\027\017\017\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.263 0 Td (\023\024\023\030\026\r\022\031 )Tj 0.386 Tw -18.263 -1.218 Td [(\207\036\027\007\032\026\n\017\027\017\226\216\024\b\002\036\030\020\026\ )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \020\030\031\023\023. \212\035\016 )Tj 0.181 Tw 0 -1.218 TD (\023\030\024\r\036\030\022\017 \024\007\027\024\030\024\007\027\024\f\021\ \017 \n\036\030\027\t\b \007\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034)Tj 0 Tw (-)Tj 0.042 Tw 0 -1.218 TD [(\022\017\b \r\t\002\024\030\022\026\b \017\f\023\024\035\034\024\r\026\035\ \017 )0.5(\024\007\027\024\235\026\022\021\024\030\027\t\005 )0.5(\007\017\f\023\036\030)]TJ 0 Tw (-)Tj 0 -1.218 TD (\f\017\024\027\027\t\005 \026\027\026\035\017.)Tj 0.083 Tw 0 -1.218 TD [(\212\035\016 \f\030\026\r\027\036\027\017\016 )0.5(\007\r\031\b )0.5(\027\036\026\r\017\f\017\n\t\b )0.5(\r\t\002\024\030\024\022 \f)]TJ /Span<>> BDC ( )Tj EMC (\n\036\030\027\t)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\n\017 \007\026\027\027\t\n\017 \023\030\017\n\036\027\016\035\017 \002\031\ \021\f\021\030\036\023 \030\036\026\035\017\026\006\017\033 t \022\030\017\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\021\036\030\017\016 \222\021\034\033\007\036\027\021\026.)Tj 0.521 Tw 0 -1.218 TD [(\212\035\016 \002\017\027\024\n\017\026\035\034\027\t\b )0.5(\017\f\b\024\007\024\r \r\t\004\017\f\035\016\035\017 \253\001\026\027\f\ \t\273 )]TJ /T1_1 1 Tf 0 Tw 0 -1.218 TD (f)Tj /T1_0 1 Tf 0.095 Tw (/\(1)Tj /Span<>> BDC ( )Tj EMC (\244)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (f)Tj /T1_0 1 Tf 0.095 Tw (\) \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\024\n \002\036\005\024\r\f\022\017\b \026\f\035\ \031\032\017\r\026\033\013\017\b \007\024)Tj 0 Tw (-)Tj -0.028 Tw 0 -1.218 TD (\r\036\030\017\016 \017\027\021\036\030\r\026\035\024\r \(\003\212\230\)\ \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \023\030\024\020\030\026\n\n\t L)35(eP)25.1(A)16(C )]TJ 0 Tw 0 -1.218 TD [(\(ht)-30(tps://er)-36.9(is62.eu/Er)-36.9(isL)35(eP)25(A)16(C.html/; 06.08.2025\))]TJ -0.002 Tc 0.387 Tw 0 -1.218 TD (\212\035\016 \023\030\024\r\036\030\022\017 \f\024\020\035\026\f\017\016\ \023\024\035\017\027\024\n\017\026\035\034\027\024\020\024 \030\026\f\023\ \030\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.605 Tw 0 -1.218 TD (\007\036\035\036\027\017\016 \030\036\f\023\024\027\007\036\027\021\024\r\ \027\026)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\031\036\n\t\b \031\030\024\r\027\016\b)-2( )]TJ 0.296 Tw 0 -1.218 TD (\030\026\r\027\024\n\036\030\027\024\n\031 \030\026\f\023\030\036\007\036\ \035\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\032\017\007\026\036\n\024\005 \007\024\035\036\005)-2( )]TJ 0.201 Tw 0 -1.218 TD (25% \023\030\017\n\036\027\016\035\017 \022\030\017\021\036\030\017\005 \ \f\024\020\035\026\f\017\016 )Tj /T1_1 1 Tf 0 Tc 0 Tw (\250)Tj 5.83 0 0 5.83 231.3884 204.5058 Tm (2)Tj /T1_0 1 Tf -0.002 Tc 0.201 Tw 10 0 0 10 234.2917 201.1758 Tm ( \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\026\n\n\036)-2( )]TJ -0.054 Tw -16.343 -1.218 Td [(L)-32(ang)17(test \(ht)-30(tps://l)-16(ang)17(test.jp/shiny/chi/; 06.08.2025\).)-2( )]TJ 0.794 Tw T* [(\233\235\235\036\022\021\t \023\030\017\027\026\r\026\035\017 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\017)-2( )]TJ 0.002 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tc 0 Tw 1.714 0 Td (p)Tj /T1_0 1 Tf -0.002 Tc -0.032 Tw /Span<>> BDC 0.476 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \212\035\016 \020\030\026\235\017\004\036\f\022\024\005 \030\036\026\ \035\017\026\006\017\017 \007\026\027\027\t\b \017\f)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -2.19 -1.218 Td [(\023\024\035\034\024\r\026\035\026\f\034 \023\030\024\020\030\026\n\n\026\ P)40.1(ast \(\r\036\030\f\017\016 5.2.2\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 115.9298 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.058 Tw 10 0 0 10 70.8661 91.5738 Tm (\206\030\031\023\023\t \030\036\f\023\024\027\007\036\027\021\024\r \027\ \036 \030\026\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\032\031 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.071 Tw 0 -1.218 TD [(\020\017\004\036\f\022\024\005 )0.5(\023\030\026\022\021\017\022\017 )0.5(\(\024\007\027\024\235\026\022\021\024\030\027\t\005 )]TJ /T1_1 1 Tf -0.053 Tc 0.053 Tw 15.449 0 Td [(AN)-33(O)-37(V)-11(A)]TJ /T1_0 1 Tf 0 Tc 0 Tw 2.533 0 Td (, )Tj /T1_1 1 Tf 0.489 0 Td (p)Tj /T1_0 1 Tf 0.071 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.585 0 Td (0,13\) )Tj 0.245 Tw 3.189 52.365 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\035\017 \024\007\027\024\030\024\007\027\031\033 \007\017\f\023\ \036\030\f\017\033 \(\021\036\f\021 \214\036\r\017\027\026 \007\035\016 \ )Tj 0.124 Tw T* [(\f\030\036\007\027\017\b )0.5(\027\026\004\036\027\017\005, )]TJ /T1_1 1 Tf 0 Tw 8.157 0 Td (p)Tj /T1_0 1 Tf 0.124 Tw /Span<>> BDC ( )Tj EMC 0.834 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.857 0 Td [(0,93\). )0.5(\222\030\036\007\027\036\036 )0.5(\027\026\004\036\027\017\036 )0.6(\f\021\026)]TJ 0 Tw (-)Tj 0.081 Tw -9.848 -1.218 Td (\032\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \211\204\215 \f\024\f\021\026\r\017\035\024 15 \(13; 16\) \035\ \036\021 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\). )Tj 0.129 Tw 0 -1.218 TD (\204\017\027\017\n\026\035\034\027\t\005 \b\017\030\031\030\020\017\004\036\ \f\022\017\005 \f\021\026\032 \030\036\f\023\024\027\007\036\027\021\024\ \r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.002 Tw 0 -1.218 TD (1)Tj /Span<>> BDC ( )Tj EMC (\020\024\007, \026)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\t\005)Tj /Span<>> BDC ( )Tj EMC [(\227 25 \035\036\021. \230\b )0.5(\007\024\035\017 \f\021\026\021\017\f\021\017\004\036)]TJ 0 Tw (-)Tj 0.012 Tw T* (\f\022\017 \027\026\004\017\n\024 \027\036 \024\021\035\017\004\026\035\ \017\f\034 \024\021 \030\026\r\027\024\n\036\030\027\024\020\024 \023\024\ \035\017\027\024)Tj 0 Tw (-)Tj T* (\n\017\026\035\034\027\024\020\024 \(\022\030\017\021\036\030\017\005 \f\ \024\020\035\026\f\024\r\026\027\027\024\f\021\017 \245)Tj 5.83 0 0 5.83 471.3848 533.3118 Tm (2)Tj 10 0 0 10 474.2997 529.9818 Tm (, )Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,066\).)Tj 0.106 Tw -17.099 -1.218 Td [(\210\023\030\024\f \b\017\030\031\030\020\024\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.241 0 Td [(\017\f\f\035\036\007\031\036\n\t\b )0.5(\211\204\215 \r\t\016\r\017\035 )0.5(\030\026\f\f\024)]TJ 0 Tw (-)Tj 0.111 Tw -8.241 -1.218 Td (\020\035\026\f\024\r\026\027\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \024\021\r\036\021\024\r \030\036\ \f\023\024\027\007\036\027\021\024\r )Tj 0.126 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\031 \007\017\026\020\027\024\f\021\017\004\036\f\022\017\ \b \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\t\b \n\036\021\024\007\024\r )Tj 0.034 Tw T* (\035\036\004\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n \233\204\233. \222\030\036\007\027\016\016 \f\021\ \036\023\036\027\034 )Tj 0.156 Tw T* [(\f\024\020\035\026\f\024\r\026\027\027\024\f\021\017 )0.6(\007\024\f\021\017\020\027\031\021\026 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.161 0 Td [(\024\021\r\036\021\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.419 0 Td (\r\024\023\030\024\f\t )Tj -0.014 Tw -18.58 -1.218 Td (\024)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\036 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\016\b \r\t\023\024\035\027\036\027\017\016 \030\031\021\017\ \027\027\024\020\024 \007\030\036\027\017\030\024\r\026)Tj 0 Tw (-)Tj 0.039 Tw T* (\027\017\016 \022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\ \021\030\026\027\f\021\r \021\026\026. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tw (-)Tj -0.026 Tw T* (\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017 \r\t\023\ \024\035\027\036\027\017\016 \024\023\036\030\026\021\017\r\027\t\b )Tj 0.289 Tw T* (\023\030\017\036\n\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\t\ \b \023\024\r\030\036\032\007\036\027\017\016\b )Tj 0.115 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \022\024\220\235\235\017\006\ \017\036\027\021 )Tj /T1_1 1 Tf 0 Tw (\003\2051 )Tj /T1_0 1 Tf 0.115 Tw 14.195 0 Td (\206\r\036\021\026 \023\030\017\002\035\017\017\035\f\016 )Tj 0.091 Tw -14.195 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \f\021\036\023\036\027\017 \f\024\020\035\026\ \f\024\r\026\027\027\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 0,383 \(0,119; )Tj 0 Tw T* (0,647\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.211 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \024\021\f\031\021\f\021\r\017\ \036 \017\035\017 \027\017\022\026\016 \f\024\020\035\026\f\024\r\026\027\ )Tj 0 Tw (-)Tj 0.012 Tw T* (\027\024\f\021\034 \007\035\016 \002\024\035\034\001\017\027\f\021\r\026\ \024\021\r\036\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\t \024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\036 )Tj 0.283 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \200\002\217\215\025 \b\017\030\031\030\020\026\n\017-\030\036\f\ \023\024\027)Tj 0 Tw (-)Tj -0.091 Tw T* (\007\036\027\021\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \233\204\233 \023\024\f\035\031\032\017\035\026 \024\f\ \027\024\r\026\027\017\036\n \007\035\016 \017)Tj 0 Tw (-)Tj T* (\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \023\030\017\004\017\027 \f\035\024\032\017\ \r\001\017\b\f\016 \023\024\007\b\024\007\024\r.)Tj /T1_3 1 Tf 0.022 Tw 0 -2.436 TD (\026\002\212\006\002\217 1:)Tj /T1_0 1 Tf ( \253\025\026\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\r\026\001\036\n \220\021\026\023\036 \024\022\026)Tj 0 Tw (-)Tj -0.015 Tw 0 -1.218 TD (\026\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\ \n\024\013\017 \016\r\035\016\036\021\f\016 \024\f\027\024\r\027\t\n \007\ \035\016 )Tj 0.005 Tw T* (\031\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026 \r\027\036\ \002\030\033\001\017\027\027\024\020\024 \030\026\027\036\027\017\016 \023\ \030\016\n\024\005 )Tj 0 Tw T* (\022\017\001\022\017?\273)Tj 0.186 Tw T* (\200 \b\024\007\036 \023\030\024\r\036\007\036\027\027\024\020\024 \026\027\ \022\036\021\017\030\024\r\026\027\017\016 \r\t\016\r\035\036\027\024, \004\ \021\024 )Tj 0.235 Tw T* (\020\030\031\023\023\t \030\036\f\023\024\027\007\036\027\021\024\r \027\ \026\004\017\n\024 \030\026\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.161 Tw T* (\002\024\030\031 \024\f\027\024\r\027\024\020\024 \n\036\021\024\007\026\ \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\025 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.347 Tw T* (\035\017\004\027\t\b \211\204\215 \(\022\030\017\021\036\030\017\005 \205\ \017\001\036\030\026\226\205\030\017\n\026\027\026\226\216\024\035\021\024\ \027\026 )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj /T1_0 1 Tf 0.018 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 328.1108 204.5058 Tm (-10)Tj 0.018 Tw 10 0 0 10 335.9929 201.1758 Tm (;\). \212\035\016 \r\f\036\b \211\204\215 \027\026\017\002\024\035\036\036\ \023\030\036\007\023\024\004\021\017\021\036\035\034\027\t)Tj 0 Tw (-)Tj -0.012 Tw -3.269 -1.218 Td (\n\017 \n\036\021\024\007\026\n\017 \007\017\026\020\027\024\f\021\017\022\ \017 \200\002\217\215\025 \016\r\035\016\035\017\f\034 \023\026\035\034\006\ \036\r\024\036 )Tj 0.163 Tw T* (\030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\r\026\027\ \017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\026\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\235\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (36 \(25; 48\))Tj /Span<>> BDC ( )Tj EMC 8.998 0 Td (%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.288 Tw -8.998 -1.218 Td [(\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\036\ )0.5(\030\026\035\017\004\017\016 \n\036\032\007\031 \030\026\027\t\n\017 )]TJ -0.118 Tw 0 -1.218 TD (\211\204\215 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \024\f\027\024\r\027\024\020\024 \n\036\021\024\007\ \026 \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\025 )Tj 0.024 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\t \007\035\016 \023\026\035\034\006\036\r\024\020\ \024 \030\036\022\021\026\035\034\027\024\020\024 \017\f\f\035\036\007\024\ \r\026\027\017\016 )Tj 0.119 Tw 0 -1.218 TD (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.119 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 494.785 119.2598 Tm (\2266)Tj /Span<>> BDC ( )Tj EMC 0.119 Tw 10 0 0 10 502.9922 115.9298 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.714 Tw -19.969 -1.218 Td (\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\226\216\ \024\b\002\036\030\020\026\), \023\030\036\007\023\024\004\017\021\026\036\ \n\024)Tj 0 Tw (-)Tj 0.115 Tw 0 -1.218 TD (\020\024 \b\017\030\031\030\020\026\n\017 \023\036\030\r\024\020\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\020\024 \211\204\215 \(78 \(50; 95\))Tj /Span<>> BDC ( )Tj EMC 21.351 0 Td (% )Tj -0.02 Tw -21.351 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (40 \(15; 69\) %, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\). \215\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\026\035\034\006\036\r\024\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \032\027\024\033\031\ \025\030\027\025\023\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC [(\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025)0.5(\022\t \026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\212\022\ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.334 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-6.9(n)-0.6(t)-32.9(s a)-9.2(t d)-3(i)5.1(f)-42.4(f)-13.3(e)-6(r)-2(e)-7(n)-0.6(t le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-3(i)-1.7(c)3.2(a)-4.5(l c)3.2(a)-4.2(r)-2(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 198.6752 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 394.2657 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 436.7854 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 703.7117 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 198.6752 703.7117 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 394.2657 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 436.7854 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 703.7117 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 692.2426 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8661 692.2426 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 692.2426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 692.2426 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 436.7854 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 681.0312 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 680.7812 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 680.7812 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 680.7812 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.3199 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 198.6752 669.3199 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 266.7067 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 479.3051 669.3199 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 216.8551 706.5463 Tm (\255\t\214\002\f\013)Tj 6.7 0 Td (2 \210\006\002\r\b\001)Tj 5.315 0 Td (3 \210\006\002\r\b\001)Tj 5.315 0 Td (4 \210\006\002\r\b\001)Tj 5.315 0 Td (5 \210\006\002\r\b\001)Tj 6.279 0 Td (\026\217\r\n\002)Tj /T1_4 1 Tf 6.458 0.001 Td (\t)Tj /T1_0 1 Tf -53.244 -1.433 Td (\025\024\035\017\004\036\f\021\r\024 \030\036\f\023\024\027\007\036\027\021\ \024\r \(\004\036\035.\))Tj /T1_4 1 Tf 19.53 0 Td (N)Tj /T1_3 1 Tf 6.666 -0.001 Td (24)Tj 5.315 0 Td (20)Tj 5.315 0 Td (22)Tj 5.593 0 Td (9)Tj 5.037 0 Td (75)Tj /T1_0 1 Tf 4.956 0.001 Td (0,066)Tj -52.411 -1.434 Td (\212\024\035\016 )Tj /T1_1 1 Tf 16.761 0 Td (f )Tj /T1_0 1 Tf (\(%\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \212\230)Tj 7.733 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(22; 46\))Tj 5.315 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(15; 41\))Tj 5.315 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(17; 44\))Tj 5.565 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(5; 24\))Tj 6.573 0 Td (100)Tj -47.262 -1.433 Td (\216\017\030\031\030\020\017\004\036\f\022\017\005 \f\021\026\032 \(\020\ \024\007\t\) )Tj /T1_1 1 Tf 17.425 0 Td (M )Tj /T1_0 1 Tf (\(95% \212\230\))Tj 7.068 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(10; 15\))Tj 5.315 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(14; 20\))Tj 5.315 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(13; 19\))Tj 5.565 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(8; 18\))Tj 5.065 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(13; 16\))Tj 6.908 0 Td (0,13)Tj /T1_1 1 Tf 7 0 0 7 70.8661 657.8353 Tm (\004\032\022\026\027\007\020\025\022\027: \030\f\t \030\031\f\027\235 \021\ )Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013 \023\031\007\025\013\027\ 95%-\027 \220\002 \n\020\n \030\f\t \033\020\032\020\026\027\023\032\031\ \021 \033\031\f\022\025\031)0.8(\026\022\020\f\017\025\031\b\031 \032\020\024\033\032\027\030\027\f\027\025\ \022\t. \004\032\027\030\024\023\020\021\f\027\025\031 \023\031\007\025\031\ \027 \032-\016\025\020\007\027\025\022\027 \030\f\t )]TJ 0 -1.2 TD [(\033\032\031\021\027\032\n\022 \024\031\b)28.1(\f\020\024\022\t \030\020\025\025\013\200 \024)]TJ /Span<>> BDC ( )Tj EMC (\032\020\021\025\031\026\027\032\025\013\026 \033\031\f\022\025\031\026\022\ \020\f\017\025\013\026 \032\020\024\033\032\027\030\027\f\027\025\022\027\ \026 \024)Tj /Span<>> BDC ( )Tj EMC [(\031\255\022\030\020\027\026\031\235)0.7( \030\031\f\027\235 25%. \220\f\t \024\023\020\255\020 \033\032\027\030\024\ \023\020\021\f\027\025\013 \024\032\027\030\025\022\027 \016\025\020\007\ \027\025\022\t \022)]TJ /Span<>> BDC ( )Tj EMC (95%-\027 )Tj 0 -1.2 TD (\220\002, \021\013\007\022\024\f\027\025\025\013\027 \026\027\023\031\030\ \031\026 \240\r\023\024\023\032\027\033\020 \022)Tj /Span<>> BDC ( )Tj EMC (\030\f\t \033\032\031\021\027\032\n\022 \031\030\025\031\032\031\030\025\ \031\024\023\022 \024\023\020\255\020 \021)Tj /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\020\200 \022\024\033\031\f\017)0.8(\016\031\021\020\f\022 \031\030\025\031\203\020\n\023\031\032\025\013\235\ \030\022\024\033\027\032\024\022\031\025\025\013\235 \020\025\020\f\022\ \016.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 20.8528 56.0378 Tm (104)Tj ET endstream endobj 961 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.017 Tw 10 0 0 10 42.5197 724.8299 Tm (\035\036\004\036\027\017\016 \023\024\f\021\030\026\007\026\r\001\017\b \ \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\n\017 \030\026\027\036\027\017\016\ \n\017 )Tj 0.009 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \031\030\024\r\027\016\b \024\022\026\026\ \027\017\016 \n\036\007\017)Tj 0 Tw (-)Tj T* (\006\017\027\f\022\024\005 \023\024\n\024\013\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 663.9399 Tm [(\207)21(\026)45(\024\034\033\031\026)-10(\r\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.238 Tw 10 0 0 10 42.5197 639.5839 Tm (\200 \024\022\021\016\002\030\036 2024 \020. \f\024\021\030\031\007\027\017\ \022\026\n\017 \022\026\235\036\007\030\t \r\024\036\027\027\024-)Tj 0.058 Tw T* (\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \023\030\024\r\036\ \007\036\027\024 \024\002\f\036\030\r\026\006\017\024\027\027\024\036 \024\ \007\027\024)Tj 0 Tw (-)Tj -0.012 Tw T* (\n\024\n\036\027\021\027\024\036 \(\023\024\023\036\030\036\004\027\024\036\ \) \017\f\f\035\036\007\024\r\026\027\017\036, \026\022\035\033\004\026\ \r\001\036)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\036\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\027\017\n\027\024\n \026\027\022\036\021\017\030\024\r\026\027\ \017\017 75 \b\017\030\031\030\020\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004. )Tj 0.189 Tw 0 -1.218 TD [(\022\024\035\024\023\030\024\022\021\024\035\024\020\024\r, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b )0.5(\211\204\215: )0.5(2 \031\030\024\r\036\027\034)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.057 Tw T* (\023\036\030\036\007\024\r\026\016 \n\036\007\017\006\017\027\f\022\026\016\ \020\030\031\023\023\026, 3 \031\030\024\r\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \n\027\024\020\024)Tj 0 Tw (-)Tj -0.031 Tw T* [(\023\030\024\235\017\035\034\027\t\005 )0.6(\r\024\036\027\027\t\005 )0.5(\020\024\f\023\017\021\026\035\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.708 0 Td [(\002\026\036 )0.5(\n\036\007\017\006\017\027\f\022\024)]TJ 0 Tw (-)Tj 0.267 Tw -14.708 -1.218 Td (\020\024 \024\021\030\016\007\026 \f\023\036\006\017\026\035\034\027\024\ \020\024 \027\026\027\026\004\036\027\017\016 \017\035\017 \035\036\004\ \036\002\027\024\005 )Tj 0.132 Tw 0 -1.218 TD (\024\030\020\026\027\017\026\006\017\017 \204\017\027\007\030\026\r\026\ \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \031\f\017\035\036\027\017\016, 4 \031\030\024\ )Tj 0 Tw (-)Tj 0.157 Tw 0 -1.218 TD (\r\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \024\022\030\031\032\027\024\005 \r\024\036\027\027\t\005 \020\024\f\ \023\017\021\026\035\034 \f)Tj /Span<>> BDC ( )Tj EMC (\235\017\035\017\026\035\026\n\017 )Tj -0.019 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\027\t\n\017 \023\024\007\030\026\007\036\ \035\036\027\017\016\n\017, 5 \031\030\024\r\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \020\035\026\r)Tj 0 Tw (-)Tj 0.209 Tw T* (\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\026\035\034\027\t\036 \r\024\036\027\027\024-\n\036\ \007\017\006\017\027\f\022\017\036 \024\030\020\026\027\017\026)Tj 0 Tw (-)Tj 0.228 Tw T* (\006\017\017. \202\027\024\027\017\n\027\024\036 \026\027\022\036\021\017\ \030\024\r\026\027\017\036 \023\030\024\r\024\007\017\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.102 Tw T* [(\023\024\035\034\024\r\026\027\017\036\n )0.6(\024\023\030\024\f\027\017\022\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.717 0 Td [(\r\017\007\036 )0.5(\024\027\035\026\005\027-\235\024\030\n\t, )0.6(\002\036 )]TJ 0.091 Tw -11.717 -1.218 Td (\031\022\026\026\027\017\016 \035\017\004\027\t\b \007\026\027\027\t\b \ \b\017\030\031\030\020\026\n\017-\030\036\f\023\024\027\007\036\027\021\026\ \n\017. )Tj 0.54 Tw T* [(\025\030\017\021\036\030\017\017 )0.5(\r\022\035\033\004\036\027\017\016: )0.5(\b\017\030\031\030\020-\030\036\f\023\024\027\007\036\027\021 )0.6(\007\024\035\032\036\027 )]TJ 0.131 Tw T* (\017\n\036\021\034 \024\023\t\021 \024\022\026\026\027\017\016 \b\017\030\ \031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\007)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\004\017\f\035\036\027\027\t\b \211\204\215. \025\030\017\ \021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016: )Tj -0.003 Tw T* (\024\021\f\031\021\f\021\r\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\030\036\f\023\024\027\007\036\027\021\026 \024\023\t\021\026 \024\022\026\ \026\027\017\016 \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\005 \023\024\n\024\013\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\004\017\f\035\036\027\027\t\b \211\204\215.)Tj 0.092 Tw T* [(\217\036\f\023\024\027\007\036\027\021\026\n )0.6(\023\030\036\007\035\026\020\026\035\024\f\034 )0.5(\024\021\r\036\021\017\021\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 17.213 0 Td [(9 )0.5(\r\024\023\030\024\f\024\r, )]TJ 0.267 Tw -17.213 -1.218 Td (\022\026\f\026\033\013\017\b\f\016 \n\036\021\024\007\024\r \007\017\026\ \020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024)Tj 0 Tw (-)Tj 0.185 Tw T* (\020\024 \035\036\004\036\027\017\016 \200\002\217\215\025, \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\n\024\032\027\024\f\021\034\033 )0.5(\r\t\002\024\030\026 \024\007\027\024\020\024 )]TJ 0.193 Tw T* (\017\035\017 \027\036\f\022\024\035\034\022\017\b \023\030\036\007\f\021\ \026\r\035\036\027\027\t\b \024\021\r\036\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r \027\036\022\024)Tj 0 Tw (-)Tj 0.114 Tw T* (\021\024\030\t\b \r\024\023\030\024\f\026\b \007\026\021\034 \f\r\024\005\ \r\026\030\017\026\027\021 \024\021\r\036\021\026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\). )Tj 0.628 Tw T* (\215\024\035\031\004\036\027\027\t\036 \024\021\r\036\021\t \030\036\f\023\ \024\027\007\036\027\021\024\r \030\026\f\023\030\036\007\036\035\036\027\ \t )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\211\204\215.)Tj 0.093 Tw T* [(\025\024\027\036\004\027\t\n\017 \021\024\004\022\026\n\017 \017\f\f\035\ \036\007\024\r\026\027\017\016 )0.5(\016\r\035\016\035\024\f\034 \023\024\035\031\004\036)]TJ 0 Tw (-)Tj 0.243 Tw T* (\027\017\036 \f\r\036\007\036\027\017\005 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\036\030\032\036\027\027\024\f\021\017 \b\017\030\031\030\020\ \024\r-\030\036\f\023\024\027)Tj 0 Tw (-)Tj 0.231 Tw T* (\007\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\027\t\n \007\017\026\020\027\024\f\021\ \017\004\036\f\022\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026)Tj 0 Tw (-)Tj 0.351 Tw T* (\021\017\r\027\t\n \n\036\021\024\007\026\n \035\036\004\036\027\017\016\ \200\002\217\215\025, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\006\036\027\022\026 )Tj 0 Tw T* (\r\027\031\021\030\036\027\027\036\005 \f\024\020\035\026\f\024\r\026\027\ \027\024\f\021\017.)Tj /T1_3 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf -0.016 Tc -0.064 Tw 0 -1.218 TD [(\204\036\021\024\007\t )0.5(\024\023\017\f\026\021\036\035\034\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.506 0 Td [(\026\027\026\035\017\021\017\004\036\f\022\024\005 )0.5(\f\021\026\021\017\f\021\017\022\017, )0.5(\023\030\017)]TJ 0 Tc 0 Tw (-)Tj -0.016 Tc 0.055 Tw -9.506 -1.218 Td (\n\036\027\036\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017, \030\036\ \026\035\017\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026)Tj 0 Tc 0 Tw (-)Tj -0.016 Tc 0.11 Tw T* [(\021\017\f\021\017\004\036\f\022\017\b \023\030\024\020\030\026\n\n\026\b\ : S)15(t)15(a)15(tX)-14(a)-17(c)-16(t v. 11.1 \(\253Cy)-16(tel Co.\273,)-16( )]TJ 0.193 Tw T* [(USA\), P)40(ast \(\r\036\030\f\017\016 5.2.2\) [7]; L)-32(ang)17(test \(ht)-30(tps://l)-16(ang)]TJ 0 Tc 0 Tw (-)Tj -0.016 Tc 0.618 Tw T* [(test.jp/shiny/chi/\); A)-25(gr)-24(eeS)15(t)15(a)15(t \(ht)-30(tps://a)-17(gr)-24(eest)15(a)15(t360.)]TJ 0 Tw 0 -1.218 TD [(com/\); L)35(eP)25(A)16(C \(ht)-30(tps://er)-37(is62.eu/Er)-37(isL)35.1(eP)25.1(A)15.9(C.html\).)]TJ 0 Tc 0.08 Tw 0 -1.218 TD (\037\036\027\021\030\026\035\034\027\t\036 \021\036\027\007\036\027\006\017\ \017 \023\030\036\007\f\021\026\r\035\036\027\t \f\030\036\007\027\017\n\ \027\026)Tj 0 Tw (-)Tj -0.037 Tw 0 -1.218 TD (\004\036\027\017\036\n \()Tj /T1_4 1 Tf 0 Tw (\215)Tj /T1_1 1 Tf -0.037 Tw (\) \017\035\017 \n\036\007\017\026\027\024\005 \()Tj /T1_4 1 Tf 0 Tw (\215\027)Tj /T1_1 1 Tf -0.037 Tw (\) \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\024\024\021)Tj 0 Tw (-)Tj 0.123 Tw 0 -1.218 TD (\r\036\021\f\021\r\017\016 \r\t\002\024\030\024\022 \023\026\030\026\n\036\ \021\030\017\004\036\f\022\024\n\031 \017\035\017 \027\036\023\026\030\026\ \n\036)Tj 0 Tw (-)Tj 0.288 Tw 0 -1.218 TD (\021\030\017\004\036\f\022\024\n\031 \030\026\f\023\030\036\007\036\035\036\ \027\017\033. \222\024\024\021\r\036\021\f\021\r\017\036 \r\t\002\024\030\ \022\017 )Tj 0.009 Tw 0 -1.218 TD (\027\024\030\n\026\035\034\027\024\n\031 \030\026\f\023\030\036\007\036\035\ \036\027\017\033 \024\023\030\036\007\036\035\016\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.912 Tw T* (\022\030\017\021\036\030\017\036\r \231\026\023\017\030\024\226\211\017\035\ \022\026, \202\027\007\036\030\f\024\027\026\226\212\026\030\035\017\027\ \020\026, )Tj 0 Tw T* (\214\017\035\035\017\036\235\024\030\f\026, \240\026\030\022\036\226\207\ \036\030\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0.389 Tw 9 0 0 9 274.9606 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \205\033\022\024\031\n \021\031\033\032\031\024\031\021, \024\203\031\032\ \026\022\032\031\021\020\025\025\013\200 \032\020\240\031\007\027\235 )Tj 0 Tw 0 -1.2 TD (\b\032\r\033\033\031\235 \030\f\t \033\032\031\021\027\030\027\025\022\t\ \022\024\024\f\027\030\031\021\020\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.233 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.206 Tw 3.529 0 Td [( )0.5(L)-1.2(i)6.6(s)-14.8(t )0.6(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 3.506 0 Td [(q)-3(u)-3.2(e)-22(s)-14.8(t)-29.1(i)-1.3(o)-4(n)3.7(s )0.5(g)-6.8(e)-7(n)-2.4(e)-6(r)3.3(a)-9.2(t)-1.6(e)-12.9(d )0.6(b)-2.4(y )0.5(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC 11.722 0 Td [(w)2.2(o)-3(r)-6.8(k)-22.4(i)4(n)-0.6(g )0.5(g)-1.5(r)-2(o)-3.4(u)-2.3(p )]TJ 0 Tw -18.757 -1.2 Td [(t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-3.9(n)-4.8(d)0.8(u)-3.7(c)-32.4(t t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.8(d)-7.2(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 274.9606 693.581 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 684.0626 cm 0 0 m 0 9.268 l S Q q 1 0 0 1 495.4587 684.0626 cm 0 0 m 0 9.268 l S Q q 1 0 0 1 274.9606 683.8126 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 655.2941 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 655.2941 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 655.0441 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 588.5336 cm 0 0 m 0 66.26 l S Q q 1 0 0 1 495.4587 588.5336 cm 0 0 m 0 66.26 l S Q q 1 0 0 1 274.9606 588.2836 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 559.7652 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 559.7652 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 559.5152 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 521.5047 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 495.4587 521.5047 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 274.9606 521.2547 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 492.7363 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 492.7363 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 492.4863 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 473.4758 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 495.4587 473.4758 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 274.9606 473.2258 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 444.7073 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 444.7073 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 444.4573 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 406.4469 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 495.4587 406.4469 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 274.9606 406.1969 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 377.6784 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 377.6784 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 377.4284 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 339.4179 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 495.4587 339.4179 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 274.9606 339.1679 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 291.6495 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 495.4587 291.6495 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 274.9606 291.3995 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 281.889 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 495.4587 281.889 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 274.9606 281.639 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 234.1206 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 495.4587 234.1206 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 274.9606 233.8706 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 224.3601 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 495.4587 224.3601 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 274.9606 224.1101 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 195.5916 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 195.5916 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 195.3416 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 119.3312 cm 0 0 m 0 75.76 l S Q q 1 0 0 1 495.4587 119.3312 cm 0 0 m 0 75.76 l S Q q 1 0 0 1 274.9606 119.0812 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 100.0627 cm 0 0 m 0 18.768 l S Q q 1 0 0 1 495.4587 100.0627 cm 0 0 m 0 18.768 l S Q q 1 0 0 1 274.9606 99.8127 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 80.8022 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 495.4587 80.8022 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 274.9606 80.5522 cm 0 0 m 220.748 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 336.2673 685.7968 Tm (\026\002\212\006\002\217 \217)Tj /Span<>> BDC ( )Tj EMC (\004\006\t\004\b\003\004\214\t \002\003\r\003\004)Tj -7.278 -1.221 Td (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\002\r \t\217\217\f\r\240\002\004\b\t\r \b\004)Tj /Span<>> BDC ( )Tj EMC (\004\230\r\214 \234\003\004\212\r \002\220\004\213\004\b\t\235 )Tj -1.352 -1.187 Td (\216\t\006\210\006\n\t\201\r\217\220\002\005 \212\002\214\002\227\t \235\ \f\235\r\003\217\235 \002\217\b\002\b\013\214 \240\f\235 \210\217\003\004\ \b\002\220\t )Tj 0 -1.187 TD (\240\t\004\n\b\002\213\004 \b\r\206\006\211\230\t\b\b\002\n\002 \006\004\ \b\r\b\t\235 \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\215\026\035\034\006\036\r\024\036 \030\036\022\021\026\035\034\027\024\036\ \017\f\f\035\036\007\024\r\026\027\017\036)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\217\036\027\021\020\036\027\024\020\030\026\235\017\016)Tj 0 Tw 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\202\027\024\f\022\024\023\017\016, \030\036\022\021\024\f\022\024\023\017\ \016, \024\f\n\024\021\030 \r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026\035\026\b)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\025\024\n\023\034\033\021\036\030\027\026\016 )-232.9(\021\024\n\024\020\030\026\235\017\016)]TJ T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (FAST-\023\030\024\021\024\022\024\035)Tj T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\205\017\002\030\024\022\024\035\024\027\024\f\022\024\023\017\016)Tj T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\204\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ )-232.8(\021\024\n\024\020\030\026\235\017\016)]TJ /T1_5 1 Tf 0 Tw 0 -1.221 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\002\005 \217\212\002\217\002\206 \226\002\006\214\t\006\002\ \004\b\t\235 \240\t\r\006\217\t\002\b\b\002\005 \220\002\f\002\217\003\ \002\214\013 )Tj -1.352 -1.187 Td (\235\f\235\r\003\217\235 \212\006\r\240\212\002\201\003\t\003\r\f\001\b\ \013\214 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\240\r\217\003\006\210\220\003\t\b\002\214 )Tj 0 -1.187 TD (\(\240\002)Tj /Span<>> BDC ( )Tj EMC (\274)Tj /Span<>> BDC ( )Tj EMC (\002\220\006\210\202\b\002\217\003\t\) \b\r\206\006\211\230\t\b\b\002\214\ \006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\212\r\031- \017\035\017 \024\007\027\024\f\021\r\024\035\034\027\026\016\ )Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\200\f\036\020\007\026 \007\r\031\f\021\r\024\035\034\027\026\016 \023\036\ \021\035\036\r\026\016)Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\200\f\036\020\007\026 \024\007\027\024\f\021\r\024\035\034\027\026\016 \ \022\024\027\006\036\r\026\016)Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\203\036 \r\f\036\020\007\026 \235\024\030\n\017\030\031\033)Tj /T1_5 1 Tf -1.056 -1.221 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\200\006\t\214\r\b\235\r\003\r \f\t \026\013 \003\006\004\b\217\f\211\214\ \t\b\004\f\001\b\002\r \210\230\t\004\b\t\r \240\r\226\r\220\003\004 )Tj -1.352 -1.187 Td (\212\006\235\214\002\005 \220\t\230\220\t \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\240\r\217\003\006\210\220\003\t\b\002\214 \(\240\002 \274 \002\220\ \006\210\202\b\002\217\003\t\) )Tj 0 -1.187 TD (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t \212\006\235\214\002\ \005 \220\t\230\220\t?)Tj /T1_1 1 Tf -0.233 Tw 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\212\026, )-233(\023\030\017\n\036\027\016\033)]TJ 0 Tw 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\203\036\021, \027\036 \023\030\017\n\036\027\016\033)Tj /T1_5 1 Tf -1.056 -1.221 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\t\214 \217\212\002\217\002\206\002\214 \026\013 \013\212\002\ \f\b\235\r\003\r \240\t\217\003\004\f\001\b\002\r \002\003\214\013\004\b\ \t\r )Tj -1.352 -1.187 Td (\002\003\220\f\211\201\r\b\b\002\005 \201\004\217\003\t \003\002\f\217\003\ \002\005 \220\t\230\220\t \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 )Tj T* (\006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \026\027\026\035\034\027\t\005 \022\026\027\026\035 \(\ \030\036\021\030\024\020\030\026\007\027\024\))Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \f\021\024\n\031 \(\026\027\021\036\020\030\026\007\027\ \024\))Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \f\021\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\t\005 \022\026\027\026\035)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\203\036 )-233(\024\021\n\t\r\026\033)]TJ /T1_5 1 Tf 0 Tw 0 -1.221 TD (5.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\t\214 \217\212\002\217\002\206\002\214 \026\013 \013\212\002\ \f\b\235\r\003\r \212\r\006\t\b\r\004\f\001\b\002\r )Tj -1.352 -1.187 Td (\240\006\r\b\t\006\002\004\b\t\r \220\f\r\003\201\004\003\002\201\b\013\ \216 \212\006\002\217\003\006\004\b\217\003 \003\004\213\004 )Tj 0 -1.187 TD (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t \212\006\235\214\002\ \005 \220\t\230\220\t?)Tj /T1_1 1 Tf -0.233 Tw 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\207\017\035\026\021\036\030\026\035\034\027\024 )-232.9(\023\026\030\026\030\036\022\021\026\035\034\027\024)]TJ 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\215\030\036\f\026\022\030\026\035\034\027\024)Tj 0 Tw T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \030\026\027\036\r\024\005 \022\026\027\026\035)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\203\036 )-233(\007\030\036\027\017\030\031\033)]TJ /T1_5 1 Tf 0 Tw 0 -1.221 TD (6.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\026 \216\002\240\r \013\212\002\f\b\r\b\t\235 \212\r\006\t\b\r\004\f\001\ \b\002\n\002 \240\006\r\b\t\006\002\004\b\t\235 )Tj -1.352 -1.187 Td (\220\f\r\003\201\004\003\002\201\b\013\216 \212\006\002\217\003\006\004\b\ \217\003 \003\004\213\004 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 )Tj 0 -1.187 TD (\006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t, \b\004)Tj /Span<>> BDC ( )Tj EMC (\220\004\220\210\211 \n\f\210\206\t\b\210 \210\217\003\004\b\004\f\t\004\ \r\003\r )Tj T* (\212\004\006\004\006\r\220\003\004\f\001\b\013\005 \240\006\r\b\004\202 \ \(\217\214\) \t)Tj /Span<>> BDC ( )Tj EMC (\220\004\220\t\214 \002\006\t\r\b\003\t\006\002\214 )Tj T* (\212\002\f\001\213\210\r\003\r\217\001 \240\f\235 \234\003\002\n\002?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\222\r\024\002\024\007\027\t\005 \r\026\030\017\026\027\021 \024\021\r\036\ \021\026)Tj /T1_5 1 Tf -1.056 -1.221 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\222\220\004\202\t\003\r \212\002\217\f\r\240\002\004\003\r\f\001\b\002\ \217\003\001 \013\212\002\f\b\r\b\t\235 \234\003\004\212\002 )Tj -1.352 -1.187 Td (\002\212\r\006\004\003\t\b\002\n\002 \214\r\230\004\003\r\f\001\217\003\ \004 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t )Tj 0 -1.187 TD (\212\006\235\214\002\005 \220\t\230\220\t \(\226\002\006\214\t\006\210\211\ \220\002\f\002\217\003\002\214\210/\217\003\002\214\210; \210\230\t\004\ \211 )Tj T* (\f\004\212\004\006\002\003\002\214\b\210\211 \006\004\b\210; \002\003\214\ \013\004\211 \240\t\217\003\004\f\001\b\210\211 \201\004\217\003\001 \220\ \t\230\220\t; )Tj T* (\240\006\r\b\t\006\210\211 \212\004\006\004\006\r\220\003\004\f\001\b\210\ \211 \220\f\r\003\201\004\003\220\210\))Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\222\r\024\002\024\007\027\t\005 \r\026\030\017\026\027\021 \024\021\r\036\ \021\026)Tj /T1_5 1 Tf -1.056 -1.221 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\004\235 \002\217\b\002\b\004\235 \204\r\f\001 \013\212\002\ \f\b\r\b\t\235 \006\210\003\t\b\b\002\n\002 )Tj -1.352 -1.187 Td (\212\004\006\004\006\r\220\003\004\f\001\b\002\n\002 \240\006\r\b\t\006\002\ \004\b\t\235 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 )Tj 0 -1.187 TD (\006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\215\030\024\235\017\035\026\022\021\017\022\026 \017\027\235\036\022\006\ \017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\ \024\030\024\027\t )Tj 0 -1.187 TD (\022\035\036\021\004\026\021\022\017 \021\026\026;)Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\222\r\024\036\r\030\036\n\036\027\027\026\016 \007\017\026\020\027\024\f\ \021\017\022\026 \017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\ \024\032\027\036\027\017\005 \f\024 )Tj T* (\f\021\024\030\024\027\t \022\035\036\021\004\026\021\022\017 \021\026\026\ )Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\217\036\026\035\017\026\006\017\016 \031\022\026\026\027\017\005 \030\ \036\020\035\026\n\036\027\021\017\030\031\033\013\017\b \007\024\022\031\ \n\036\027\021\024\r )Tj T* (\(\031\022\026\026\027\017\005 \f\021\026\030\001\036\020\024 \n\036\007\ \017\006\017\027\f\022\024\020\024 \027\026\004\026\035\034\027\017\022\026\ \))Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\203\036 \r\t\023\024\035\027\016\033 \030\031\021\017\027\027\024\036 \007\ \030\036\027\017\030\024\r\026\027\017\036 \023\026\030\026\030\036\022\021\ \026\035\034\027\024\005 )Tj T* (\022\035\036\021\004\026\021\022\017)Tj /T1_5 1 Tf -1.056 -1.221 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\026\013\212\002\f\b\235\r\003\r \f\t \026\013 \240\t\210\f\001\217\t\211\ \217\226\t\b\220\003\r\006\004 )Tj -1.352 -1.187 Td (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t \212\006\235\214\002\ \005 \220\t\230\220\t?)Tj /T1_1 1 Tf -0.233 Tw 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\212\026)Tj 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\203\036\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 505.4771 56.0378 Tm (103)Tj ET endstream endobj 960 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 551.2534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 551.2534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 514.0455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 514.0455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 459.9764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf -0.001 Tw 9 0 0 9 119.0551 730.4919 Tm [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: in October 2024, an obser)-41.9(v)16(ational cross-sectional study for patients with e)-15(xtraper)-36.9(itoneal )]TJ 0.098 Tw 0 -1.111 TD [(rectal w)12(ounds w)13(as done using an anon)11(ymous q)14(uestionnaire online, in which 75 surg)12(eons took par)-40(t. R)21(espondents )]TJ 0.042 Tw T* [(w)12(ere divided into four g)14(roups depending on the character)-36.9(istics of the medical ev)16(acuation stag)12(e. Inclusion cr)-36.9(iter)-37(ia: )]TJ 0.045 Tw T* [(the respondent surg)12.1(eon must hav)13(e e)-15(xper)-37(ience in p)46(roviding surgical care at one of the listed lev)12.9(els of medical care. )]TJ 0.023 Tw T* [(Exclusion cr)-37(iter)-37(ia: the respondent has no e)-15(xper)-37(ience in p)45.9(roviding surgical care at the listed lev)13(els of medical care.)]TJ -0.006 Tc -0.026 Tw 0 -1.111 TD [(RESUL)30.1(T)-10(S: a sur)-42(v)13(ey of surg)12(eons at v)16(ar)-37(ious lev)13(els of medical care rev)13(ealed a lack of or low inter)-14(nal consistency in most of)-6( )]TJ 0.02 Tw 0 -1.111 TD [(the respondents)33(\222 answ)12.1(ers at each lev)13(el of medical care. A moderate deg)14(ree of consistency w)13(as achiev)13(ed when answ)12(er)]TJ 0 Tc 0 Tw 44.743 0 Td (-)Tj -0.006 Tc 0.003 Tw -44.743 -1.111 Td [(ing )0.6(q)14(uestions )0.6(about )0.6(the )0.5(method )0.5(and )0.5(pur)-18(poses )0.5(of )0.6(per)-34(for)-14(ming )0.5(routine )0.5(drainag)12(e )0.6(of )0.5(pelvic )0.5(cellular )0.5(spaces. )0.6(In )0.5(the )0.6(answ)12(ers)-6( )]TJ 0.047 Tw T* [(to )0.5(the )0.5(q)14(uestion )0.5(about )0.5(the )0.5(seq)14(uence )0.5(of )0.5(per)-34(for)-14(ming )0.5(surgical techniq)14(ues )0.5(for )0.5(e)-15(xtraper)-36.9(itoneal injur)-37(ies )0.5(of )0.5(the )0.5(rectum, the)-5.9( )]TJ 0.023 Tw T* [(A)26(C1 Gv)13(et coef)-40(f)-43(icient app)46(roaches the mean deg)13.9(ree of ag)14(reement \(0.383 \(95% conf)-43(idence inter)-41.9(v)16(al: 0.119; 0.647\)\).)]TJ 0 Tc 0.018 Tw T* [(C)21(ON)22(CLUSION: one of the op)13(tions for unif)-43(ied app)46(roach to p)46(roviding surgical care for e)-15.1(xtraper)-37(itoneal rectal w)12(ounds is )]TJ 0.016 Tw T* [(to conduct a study using by the Delphi method with the in)11(v)13(olv)13(ement of a g)14(roup of e)-15(xper)-39.9(ts, follow)12(ed by the dev)13(elop)]TJ 0 Tw (-)Tj 0.043 Tw T* [(ment and im)16(plementation, based on a consensus decision, of algor)-36.9(ithms for the treatment of this type of injur)-43(y at )]TJ 0.023 Tw T* [(the stag)12(es of medical ev)16(acuation.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 585.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.099 Tw 4.948 0 Td [( e)-15(xtraper)-37(itoneal rectal injur)-36.9(ies, 4D-concep)13(t, d)26(amag)12(e control, multi-stag)12(e surgical treatment, gunsho)13(t w)12(ounds, pararectal drainag)12.1(e, )]TJ 0.023 Tw -4.953 -1.2 Td [(stag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(medical ev)16(acuation)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.037 Tc -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.6(C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.032 Tw 6.467 0 Td [( )0.5(S)-12.1(u)-7.6(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 2.976 0 Td [(D)16.4(.)-23.9(A)-23(.)-23.5(, )0.5(E)-25.2(s)-22.9(e)-18(l)-23.6(e)-15.9(v)-51.7(i)-5(c)-10.2(h)]TJ /Span<>> BDC ( )Tj EMC 6.755 0 Td [(R)-21.4(.)40.6(V)39.7(.)-23.5(, )0.5(A)-11.7(l)-16.7(i)-3.2(m)-12.4(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 5.408 0 Td [(P)107.7(.)-23.9(A)-23(.)-23.5(, )0.5(B)-16.4(a)-11.4(l)-8.2(y)-21.5(u)-7.6(r)-30.8(a)]TJ /Span<>> BDC ( )Tj EMC 5.761 0 Td [(O)11.4(.)40.6(V)39.7(.)-23.5(, )0.5(R)-6.5(u)-7(m)-15.4(y)-24.2(a)-7.6(n)-17.3(t)-48.9(s)-22.9(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 7.696 0 Td [(V)39.7(.)-1.9(N)-2.8(.)-23.5(, )0.5(B)-16.4(a)-10.2(r)-18.1(d)-9.3(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.486 0 Td [(S)-9.6(.)-1.9(N)-2.8(.)-23.5(, )0.5(Z)-17.7(o)-15.8(t)-21.9(o)-10.3(v )0.5(K)-27(.)51.7(Y)12.6(u)-9(.)-23.5(, )0.5(O)-30.3(v)-11.6(c)-10.2(h)-14(i)-3.2(n)-5.7(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 13.286 0 Td [(D)16.4(.)40.6(V)39.7(.)-23.5(,)23( )]TJ 0.003 Tw -54.841 -1.2 Td [(D)-34(y)-27.5(m)-6.2(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-23(.)-23.5(, K)-11.2(o)-11.8(r)-42.9(z)-12.6(h)-7(u)-9.6(k)]TJ /Span<>> BDC ( )Tj EMC [(M)-7(.)-27(S)-9.6(. C)-16.5(o)-9.2(n)-17.3(t)-30.8(r)-15.7(o)-10.3(v)-18.7(e)-12.1(r)-30.3(s)-26.1(i)-5.1(a)-11.4(l i)-7.4(s)-22.3(s)-8.8(u)-12.5(e)-22.8(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-15.8(i)-5.1(a)-10.8(g)-8.8(n)-11.9(o)-15.8(s)-26.1(i)-7.4(s a)-7.6(n)-14.5(d m)-8.1(u)-8.4(l)-15.4(t)-46.2(i)-12.8(-)-13.5(s)-29.3(t)-36.8(a)-10.8(g)-14.4(e s)-8.8(u)-7.6(r)-16.7(g)-28.9(i)-5(c)-21.5(a)-11.4(l t)-30.8(r)-19(e)-13(a)-18.2(t)-26.1(m)-16.6(e)-11.5(n)-17.3(t i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(p)-20(a)-18.2(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h e)-33.1(x)-44.8(t)-30.8(r)-30.8(a)-8.8(p)-24.7(e)-12.1(r)-56.4(i)-15.8(t)-21.9(o)-9.2(n)-16.1(e)-13(a)-11.4(l)23( )]TJ 0.024 Tw 0 -1.2 TD [(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l w)-13.5(o)-13.3(u)-5(n)-14.5(d)-24.7(s)-15.4(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw 6.718 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)14(0)-1.5(1)26.4(\226)50.8(1)29.8(1)0.9(5)6.9(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.2(1)26.8(-)55.2(1)14(0)-1.6(1)26.9(-)55.2(1)29.7(1)0.9(5)]TJ /T1_1 1 Tf 0.01 Tc 0.1 Tw -13.733 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.105 Tw 10.74 0 Td ( \036\024\027\f\027\021\022\007 \206\031\026\020\025 \211\f\020\030\022\026\ \022\032\031\021\022\007, \214\216\221\211\217\210 \211\217 \253\211\031\ \027\025\025\031-\026\027\030\022\006\022\025\024\n\020\t \020\n\020\030\ \027\026\022\t \022\026. \205.\215.)Tj /Span<>> BDC ( )Tj EMC (\202\022\032\031\021\020\273, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\003\n\020\030\027\026\022\n\020 )Tj 0.023 Tw -10.745 -1.2 Td (\035\027\240\027\030\027\021\020, \030.)Tj /Span<>> BDC ( )Tj EMC (6, \205\020\025\n\023-\004\027\023\027\032\240\r\032\b, 194044, \206\031\ \024\024\022\t; \023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(911\) 128-21-05; e-mail: r_eselevich@mail.ru)Tj /T1_1 1 Tf 0.01 Tc 0.057 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.062 Tw 14.129 0 Td [( Eselevich R.V)61(., S.M.)]TJ /Span<>> BDC ( )Tj EMC [(Kirov Militar)-42.9(y Medical Academ)11.1(y)41.9(, Ak)11(ademik)11.1(a Lebedev)16.1(a st., 6J, Saint P)15(etersburg, 194044, )]TJ 0.023 Tw -14.134 -1.2 Td [(R)22(ussia;)]TJ /Span<>> BDC ( )Tj EMC (tel.: +7 \(911\) 128-21-05; e-mail: r_eselevich@mail.ru)Tj 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 18.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 396.0239 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf -0.01 Tc 0.168 Tw 10 0 0 10 70.8661 371.6679 Tm (\210\020\027\036\f\021\030\036\035\034\027\t\036 \030\026\027\036\027\017\ \016 \r\027\036\002\030\033\001\017\027\027\024\020\024 \024\021\007\036\ \035\026 \023\030\016)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.082 Tw 0 -1.218 TD (\n\024\005 \022\017\001\022\017 \016\r\035\016\033\021\f\016 \024\007\027\ \017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \021\016\032\036\035\t\b \r\017)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.047 Tw T* (\007\024\r \023\024\r\030\036\032\007\036\027\017\016 \024\030\020\026\027\ \024\r \032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\021\026\026, \023\030\036\007\f\021\026\r\035\016\016)-10( )]TJ 0.099 Tw T* [(\f\024\002\024\005 )0.6(\026\022\021\031\026\035\034\027\031\033 )0.5(\023\030\024\002\035\036\n\031 )0.5(\f\024\r\030\036\n\036\027\027\024\005 )0.5(\002\024\036\r\024\005 )0.5(\b\017)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc -0.024 Tw T* (\030\031\030\020\017\004\036\f\022\024\005 \021\030\026\r\n\t. \212\024\035\ \016 \030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC [(\r\027\036\002\030\033\001\017\027\027\t\n\017)-10( )]TJ 0.11 Tw T* [(\030\026\027\036\027\017\016\n\017 \023\030\016\n\024\005 \022\017\001\022\ \017 \(\200\002\217\215\025\) \007\024\f\021\017\020\026\036\021 3,4% \024\ \021)-10( )]TJ -0.026 Tw T* (\r\f\036\b \030\026\027\036\027\017\005 \032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\026 [1]. \212\026\027\027\t\005 \235\026\022\021 \024\002\031\f\ \035\024\r)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.228 Tw T* (\035\036\027 \027\036 \021\024\035\034\022\024 \r\t\f\024\022\024\017\027\ \021\036\027\f\017\r\027\t\n \b\026\030\026\022\021\036\030\024\n \002\024\ \036)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.085 Tw T* (\f\021\024\035\022\027\024\r\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \r\024\024\030\031\032\036\027\027\t\b\ \022\024\027\235\035\017\022)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc -0.001 Tw T* (\021\026\b, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\036\n \007\024\035\017 \021\016\032\036\035\ \t\b \017)Tj /Span<>> BDC ( )Tj EMC 15.575 0 Td [(\022\030\026\005\027\036 \021\016\032\036\035\t\b)-10( )]TJ 0.128 Tw -15.575 -1.218 Td (\023\024\r\030\036\032\007\036\027\017\005 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \031\r\036\035\017\004\036\027\017\016 \022\024\035\017\004\ \036\f\021\r\026 \n\027\024\032\036)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.123 Tw T* [(\f\021\r\036\027\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.959 0 Td [(\f\024\004\036\021\026\027\027\t\b )0.5(\030\026\027\036\027\017\005 )0.5([2]. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.588 0 Td [(\220\021\024\n )0.5(\n\036\007\017)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc 0.019 Tw -17.547 -1.218 Td [(\006\017\027\f\022\017\036 )0.5(\f\023\036\006\017\026\035\017\f\021\t, )0.5(\027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 )0.5(\024\022\026\t\r\026\033\013\017\036)-10( )]TJ 0.193 Tw T* (\023\024\n\024\013\034 \030\026\027\036\027\t\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b \220\021\026\023\026\b \n\036\007\017\006\017\ \027\f\022\024\005)-10( )]TJ 0.228 Tw T* (\220\r\026\022\031\026\006\017\017 \(\233\204\233\), \f\021\026\035\022\017\ \r\026\033\021\f\016 \027\036 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\031\007\027\024)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.047 Tw T* (\f\021\016\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 \007\017\026\020\027\024\f\021\017\022\036 \200\ \002\217\215\025, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\f \023\030\024\002\035\036\n\024\005)-10( )]TJ 0.1 Tw T* [(\024\021\f\031\021\f\021\r\017\016 )0.5(\036\007\017\027\024\020\024 )0.5(\023\024\007\b\024\007\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.696 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.5(\021\026\022\021\017\022\036)-10( )]TJ 0 Tw -12.696 -1.218 Td (\035\036\004\036\027\017\016 \007\026\027\027\024\005 \022\026\021\036\020\ \024\030\017\017 \023\024\f\021\030\026\007\026\r\001\017\b [3].)Tj -0.006 Tc 0.343 Tw T* (\025\024\027\006\036\023\006\017\016 \b\017\030\031\030\020\017\004\036\f\ \022\024\005 \023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\r\024\024\030\031\032\036\027\027\t\b)-6( )]TJ 0.169 Tw T* (\022\024\027\235\035\017\022\021\026\b \023\030\036\007\031\f\n\026\021\030\ \017\r\026\036\021 \023\030\036\036\n\f\021\r\036\027\027\024\f\021\034 \ \007\017\026\020)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.098 Tw T* [(\027\024\f\021\017\004\036\f\022\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.238 0 Td [(\035\036\004\036\002\027\024-\220\r\026\022\031\026\006\017\024\027\027\t\ \b )0.5(\n\036\030\024\023\030\017\016\021\017\005,)-6( )]TJ 0.356 Tw -6.238 -1.218 Td (\r\t\023\024\035\027\016\036\n\t\b \023\024\f\035\036\007\024\r\026\021\036\ \035\034\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\t\b \031\030\024\r\027\016\b)-6( )]TJ 0.039 Tw T* (\024\022\026\026\027\017\016 \n\036\007\017\006\017\027\f\022\024\005 \023\ \024\n\024\013\017 \(\211\204\215\) \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \n\036\007\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.04 Tw T* (\022\024-\021\026\022\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\ \024\r\022\017. \003\026\022\024\027\024\n\036\030\027\t\n \f\035\036\007\ \f\021\r\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.264 Tw T* [(\036\n \220\r\024\035\033\006\017\017 \035\036\004\036\002\027\024-\220\r\ \026\022\031\026\006\017\024\027\027\t\b \n\036\030\024\023\030\017\016\021\ \017\005,)-6( )]TJ 0.28 Tw 23.244 31.663 Td (\r\024 \n\027\024\020\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\031\013\036\f\021\r\036\027\027\t\n\017 \017\n\036\027\036\027\017\016\ \n\017)-6( )]TJ 0.302 Tw T* (\b\026\030\026\022\021\036\030\026 \002\024\036\r\t\b \007\036\005\f\021\ \r\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \r\024\024\030\031)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.018 Tw T* [(\032\036\027\027\t\b )0.5(\022\024\027\235\035\017\022\021\026\b, )0.5(\f\021\026\035\024 )0.6(\f\024\024\021\r\036\021\f\021\r\017\036 )0.5(\022\026\032\007\024\n\031 )0.5(\233\204\233)-6( )]TJ 0.316 Tw T* (\024\023\030\036\007\036\035\036\027\027\024\020\024 \211\204\215. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\036\007\024\r\t\b \233\204\233,)-6( )]TJ -0.039 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.655 0 Td [(\r\017\007\031 )0.5(\024\020\030\026\027\017\004\036\027\027\024\f\021\017 )0.5(\030\036\f\031\030\f\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.46 0 Td [(\030\026\f\023\024\035\024\032\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.775 0 Td (\024\021)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.051 Tw -20.89 -1.218 Td (\027\024\f\017\021\036\035\034\027\024\005 \002\035\017\024\f\021\017 \022\ )Tj /Span<>> BDC ( )Tj EMC (\035\017\027\017\017 \002\024\036\r\024\020\024 \f\024\023\030\017\022\024\ \f\027\024\r\036)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.143 Tw T* [(\027\017\016, \r\t\023\024\035\027\017\021\034 \007\024\f\021\026\021\024\ \004\027\t\005 \024\002\255\036\n \007\017\026\020\027\024\f\021\017\004\ \036\f\022\017\b)-6( )]TJ 0.03 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\002\027\t\b \n\036\030\024\023\030\017\016\021\017\005 \ \026\004\026\f\021\031\033 \027\036 \023\030\036\007\f\021\026\r\035\016\ \036\021\f\016)-6( )]TJ 0.085 Tw T* (\r\024\n\024\032\027\t\n [2,4]. \212\026\027\027\024\036 \024\002\f\021\ \024\016\021\036\035\034\f\021\r\024 \024\002\031\f\035\024\r\035\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.005 Tw T* (\r\026\036\021 \023\024\007\027\036\036 \r\t\016\r\035\036\027\017\036 \ \200\002\217\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (91,9% \030\026\027\036\027\t\b, \023\030\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc T* (\004\036\n \021\030\036\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \r\t\016\r\035\016\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (5 \211\204\215 [1,5,6].)Tj -0.016 Tc 0.275 Tw T* [(\221\026\022\017\n \024\002\030\026\024\n, \026\022\021\031\026\035\034\ \027\024\f\021\034 \023\030\024\002\035\036\n\t \007\017\026\020\027\024\ \f\021\017\022\017)-16( )]TJ -0.022 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \200\002\217\215\025 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \f\024\r\030\036\n\036\027)Tj 0 Tc 0 Tw (-)Tj -0.016 Tc 0.016 Tw T* [(\027\t\b )0.5(\r\024\024\030\031\032\036\027\027\t\b )0.5(\022\024\027\235\035\017\022\021\024\r )0.5(\023\030\024\007\017\022\021\024\r\026\027\026, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.126 0 Td [(\023\036\030\r\031\033)-16( )]TJ 0.107 Tw -19.126 -1.218 Td (\024\004\036\030\036\007\034, \n\027\024\020\024\020\030\026\027\027\024\ \f\021\034\033 \007\036\005\f\021\r\031\033\013\036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036)-16( )]TJ 0.128 Tw T* [(\r\030\036\n\016 \022\024\027\006\036\023\021\031\026\035\034\027\024\020\ \024 \023\024\007\b\024\007\026, \024\021\f\031\021\f\021\r\017\036\n \036\ \007\017\027\024\020\024)-16( )]TJ 0.027 Tw T* (\023\024\027\017\n\026\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \021\026\022\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024)Tj 0 Tc 0 Tw (-)Tj -0.016 Tc 0.133 Tw T* (\f\021\017 \036\036 \030\036\026\035\017\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b \211\204\215. \222\031\013\036\f\021\r\031\ \033\013\026\016)-16( )]TJ 0.238 Tw T* (\030\026\027\024\030\024\007\027\024\f\021\034 \023\024\007\b\024\007\024\ \r \022)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\033 \200\002\217\215\025 \016\r\035\016\036\021\ \f\016)-16( )]TJ -0.016 Tw T* [(\023\030\036\007\017\022\021\024\030\024\n )0.5(\007\024\f\021\026\021\024\004\027\024 )0.5(\r\t\f\024\022\024\005 )0.5(\004\026\f\021\024\021\t )0.5(\030\026\r\017\021\017\016 )0.5(\024\f)]TJ 0 Tc 0 Tw (-)Tj -0.016 Tc -0.072 Tw T* (\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 \023\026\006\ \017\036\027\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 115.9299 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.455 Tw 10 0 0 10 303.3071 91.5739 Tm [(\210\006\036\027\017\021\034 )0.5(\023\030\017\r\036\030\032\036\027\027\024\f\021\034 )0.5(\023\030\026\022\021\017\022\031\033\013\017\b )0.6(\b\017\030\031\030\020\024\r )]TJ 0.058 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n \n\036\021\024\007\026\n \007\017\026\020\027\ \024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (102)Tj ET endstream endobj 957 0 obj [964 0 R] endobj 958 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 285.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 285.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 248.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 248.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-101-115)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 79.1689 695.3259 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022)-23.3(\024\t\025\013)10(\025)21(\237\026)11(\017\224\t\025\013)10(\025 )]TJ -1.329 -1.105 Td [(\220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \224\017\n\004\t\026)11.1(\025\b \016\022)-23.3(\b\t\004\255\005\206\204\n\t\t\217\024\n )]TJ 5.976 -1.105 Td (\005\017\t\004\t\n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)Tj 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 628.822 Tm [(\001\002\005\025\b\022)-23.3(\201.\f)-30.9(.)]TJ 8.162 0 0 8.162 108.337 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 112.9729 628.822 Tm [(, \240\016\004\020\004\b\n\225\022)-23.2(\033)124(.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 196.616 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 207.9366 628.822 Tm [(, \f)-21(\020\n\024\025\b\022)-23.2(\034.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 290.2913 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 294.9272 628.822 Tm [(, \006\017\020\206\005\017\022)-23.2(\036.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 378.0663 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 389.3869 628.822 Tm [(, \033)-21(\002\024\213\t\004\b\022)-23.2(\021.\007.)]TJ 0 Tw 8.162 0 0 8.162 479.1757 633.484 Tm (1)Tj 14 0 0 14 483.8116 628.822 Tm (, )Tj -31.521 -1.143 Td [(\006\017\005\202\017\r)10(\025\b\022)-23.2(\001.\007.)]TJ 8.162 0 0 8.162 127.0269 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 131.6628 612.822 Tm [(, \203\025\026)11(\025\b\022)-23.2(\037.\207.)]TJ 0 Tw 8.162 0 0 8.162 206.4723 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 211.1083 612.822 Tm [(, \036\b)21(\225\n\t\t\n\r)10.1(\025\b\022)-23.3(\201.\021.)]TJ 0 Tw 8.162 0 0 8.162 317.3048 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 321.9407 612.822 Tm [(, \201\217\024\t\n\r)10.1(\025\b\022)-23.3(\201.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 418.4212 617.484 Tm (1)Tj 14 0 0 14 423.0572 612.822 Tm (, )Tj -27.181 -1.143 Td [(\037)31(\025\005\226\002\r\022)-23.3(\235.\001.)]TJ 8.162 0 0 8.162 118.0532 601.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 582.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 579.1527 Tm [(\210\031\006\021\036)20(\227 \021\036 \253\021\025\004\t\t\025-\024\004\202\n\n\t\016\r\017\213\ \017\r\017\202\004\024\n\213 \n\024.\022)-23.3(\001.\235.\022)-23.3(\037)20(\n\005\025\b\017\273 \(\002\020.\022)-23.3(\f\r\017\202\004\024\n\r\017 \035\004\255\004\202\004\b\017, \202.\022)-23.3(6\223, \013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-)]TJ -0.331 -1.2 Td [(\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)80(40)25(44, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 558.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 555.1527 Tm [(\215\036)20(\227\021\036 \253\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)10.1(\016\r\n\221 \024\004\202\n\r)10(\025-\016\025\n\017\020\200\t\217\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026\273 \(\224\005-)-41.9(\026 \037)31(\025\t\202\005\017\026\200\004\b\016\r\n\221, \202.\022)-23.3(7)58(2, \020\n\026)11(\004\005 \f)-52(, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)46(5)35(2)46(7)127(1)69(, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0 Tw 9 0 0 9 90.7087 524.6488 Tm (\037\036\035\034: \031\006\027\025\022\023\017 \033\032\022\021\027\032\255\ \027\025\025\031\024\023\017 \033\032\020\n\023\022\n\r\005\212\022\200 \ \200\022\032\r\032\b\031\021 \n)Tj /Span<>> BDC ( )Tj EMC (\026\027\023\031\030\020\026 \030\022\020\b\025\031\024\023\022\n\022 \022\ )Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\031\b\031 \f\027\007\027\025\022\t\ )Tj 0.148 Tw 0 -1.111 TD [(\033\031\024\023\032\020\030\020\021\213\022\200 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\021\025\027\240\032\005\213\022\025\025\013\026\022 \032\020\025\027\025\ \022\t\026\022 \033\032\t\026\031\235 )0.5(\n\022\213\n\022 \025\020)]TJ /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025\024\n\031\235 )Tj 0.023 Tw T* (\033\031\026\031\212\022 \(\210\215\004\).)Tj 0.026 Tw T* (\215\003\036\206\002\003\035\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\031\n\023\t\240\032\027 2024 \b\031\030\020 \033\032\031\021\027\030\027\ \025\031 \031\240\024\027\032\021\020\006\022\031\025\025\031\027 \033\031\ \033\027\032\027\007\025\031\027 \022\024\024\f\027\030\031\021\020\025\022\ \027 \026\027\023\031\030\031\021 )Tj 0.018 Tw T* (\030\022\020\b\025\031\024\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\031\235 \023\020\n\023\022\n\022 \ \f\027\007\027\025\022\t \033\031\024\023\032\020\030\020\021\213\022\200\ \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\240\032\005\213\022\025\025\013\026\022 \032\020\025\027\025\ \022\t\026\022 \033\032\t\026\031\235 \n\022\213\n\022 )Tj 0.126 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \020\025\031\025\022\ \026\025\031\b\031 \031\033\032\031\024\025\022\n\020 \021)Tj /Span<>> BDC ( )Tj EMC (\021\022\030\027 \031\025\f\020\235\025-\203\031\032\026\013, \021)Tj /Span<>> BDC ( )Tj EMC (\n\031\023\031\032\031\026 \033\032\022\025\t\f\022 \r\007\020\024\023\022\ \027 75 \200\022\032\r\032\b\031\021. )Tj 0.027 Tw T* (\206\027\024\033\031\025\030\027\025\023\013 \240\013\f\022 \032\020\024\ \033\032\027\030\027\f\027\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (\007\027\023\013\032\027 \b\032\r\033\033\013 \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \200\020\032\020\n\ \023\027\032\022\024\023\022\n \204\023\020\033\020 \026\027\030\022\006\ \022\025\024\n\031\235 )Tj 0.151 Tw T* (\204\021\020\n\r\020\006\022\022 \(\230\215\230\). \202\032\022\023\027\032\ \022\022 \021\n\f\005\007\027\025\022\t: \200\022\032\r\032\b-\032\027\024\ \033\031\025\030\027\025\023 \030\031\f\255\027\025 \022\026\027\023\017\ \031\033\013\023 \031\n\020\016\020\025\022\t \200\022\032\r\032\b\022\007\ \027\024\n\031\235 )Tj 0.042 Tw 0 -1.111 TD (\033\031\026\031\212\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\026 \022\016)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\027\007\022\024\f\027\025\025\013\200 \210\215\004. \202\032\ \022\023\027\032\022\022 \022\024\n\f\005\007\027\025\022\t: \031\023\024\ \r\023\024\023\021\022\027 \r)Tj /Span<>> BDC ( )Tj EMC (\032\027\024\033\031\025\030\027\025\023\020 \031\033\013\023\020 \031\n\ \020\016\020)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\025\022\t \200\022\032\r\032\b\022\007\027\024\n\031\235 \033\031\026\031\ \212\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\027\007\022\024\f\027\025\025\013\200 \210\215\004.)Tj 0.235 Tw T* (\206\036\207\210\035\034\003\201: \031\033\032\031\024 \200\022\032\r\032\ \b\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \210\215\004 \021\013\t\021\022\f \031\ \023\024\r\023\024\023\021\022\027 \022\f\022 \025\022\016\n\r\005 \021\025\ \r\023\032\027\025\025\005\005 \024\031\b\f\020\024\031)Tj 0 Tw (-)Tj 0.306 Tw T* (\021\020\025\025\031\024\023\017 \021)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\017\213\022\025\024\023\021\027 \031\023\021\027\023\031\021 \ \032\027\024\033\031\025\030\027\025\023\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC (\n\020\255\030\031\026 \230\215\230. \205\032\027\030\025\t\t \024\023\027\ \033\027\025\017 \024\031\b\f\020\024\031\021\020\025\025\031\024\023\022\ )Tj 0.101 Tw T* (\030\031\024\023\022\b\025\r\023\020 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\031\023\021\027\023\027 \025\020)Tj /Span<>> BDC ( )Tj EMC (\021\031\033\032\031\024\013 \031)Tj /Span<>> BDC ( )Tj EMC (\024\033\031\024\031\240\027 \022)Tj /Span<>> BDC ( )Tj EMC (\006\027\f\t\200 \021\013\033\031\f\025\027\025\022\t \032\r\023\022\025\ \025\031\b\031 \030\032\027\025\022\032\031\021\020\025\022\t \n\f\027\023\ \007\020\023\031\007)Tj 0 Tw (-)Tj 0.134 Tw T* [(\025\013\200 )0.6(\033\032\031\024\023\032\020\025\024\023\021 )0.6(\023\020\016\020. )0.6(\211)]TJ /Span<>> BDC ( )Tj EMC 11.551 0 Td [(\031\023\021\027\023\020\200 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 5.439 0 Td [(\021\031\033\032\031\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 4.013 0 Td [(\033\031\024\f\027\030\031\021\020\023\027\f\017\025\031\024\023\022 )0.6(\021\013\033\031\f\025\027\025\022\t )0.5(\031\033\027\032\020\023\022\021\025\013\200 )0.6(\033\032\022\027\026\031\021 )]TJ 0.008 Tw -21.002 -1.111 Td (\033\032\022)Tj /Span<>> BDC ( )Tj EMC 1.717 0 Td [(\204\n\024\023\032\020\033\027\032\022\023\031\025\027\020\f\017\025\013\ \200 )0.7(\033\031\021\032\027\255\030\027\025\022\t\200 )0.5(\033\032\t\026\031\235 )0.6(\n\022\213\n\022 )0.5(\n\031\204\203\203\022\006\022\027\025\023 )0.5(\003\2051 )0.5(\216\021\027\023\020 )0.5(\033\032\022\240\f\022\255\020\027\023\024\t )0.5(\n)]TJ /Span<>> BDC ( )Tj EMC 40.064 0 Td (\024\032\027\030\025\027\235 )Tj 0.023 Tw -41.781 -1.111 Td (\024\023\027\033\027\025\022 \024\031\b\f\020\024\031\021\020\025\025\031\ \024\023\022 \(0,383 \(95% \030\031\021\027\032\022\023\027\f\017\025\013\ \235 \022\025\023\027\032\021\020\f: 0,119; 0,647\)\).)Tj 0.25 Tw T* (\207\003\202\035\224\232\036\001\002\036: \031\030\025\022\026 \022\016)Tj /Span<>> BDC ( )Tj EMC (\021\020\032\022\020\025\023\031\021 \203\031\032\026\022\032\031\021\020\ \025\022\t \027\030\022\025\031\b\031 \033\031\030\200\031\030\020 \n)Tj /Span<>> BDC ( )Tj EMC (\031\n\020\016\020\025\022\005 \200\022\032\r\032\b\022\007\027\024\n\031\ \235 \033\031\026\031\212\022 )Tj -0.041 Tw 0 -1.111 TD (\033\032\022)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\240\032\005\213\022\025\025\013\200 \032\020\025\027\025\022\ \t\200 \033\032\t\026\031\235 \n\022\213\n\022 \t\021\f\t\027\023\024\t \ \033\032\031\021\027\030\027\025\022\027 \022\024\024\f\027\030\031\021\020\ \025\022\t \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\022\026\027\025\027\025\022\027\026 \220\027\f\017\203\022\235\024\ \n\031\b\031 )Tj 0.004 Tw 0 -1.111 TD [(\026\027\023\031\030\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 4.165 0 Td [(\033\032\022\021\f\027\007\027\025\022\027\026 )0.6(\b\032\r\033\033\013 )0.6(\204\n\024\033\027\032\023\031\021, )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 14.633 0 Td [(\033\031\024\f\027\030\r\005\212\027\235 )0.6(\032\020\016\032\020\240\031\023\n\031\235 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 12.217 0 Td [(\021\025\027\030\032\027\025\022\027\026 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 5.783 0 Td [(\033\032\020\n\023\022\n\r )0.6(\025\020)]TJ /Span<>> BDC ( )Tj EMC 5.475 0 Td (\031\024\025\031\021\027 )Tj 0.023 Tw -42.272 -1.111 Td (\n\031\025\024\027\025\024\r\024\025\031\b\031 \032\027\213\027\025\022\t\ \020\f\b\031\032\022\023\026\031\021 \f\027\007\027\025\022\t \030\020\025\ \025\031\b\031 \021\022\030\020 \032\020\025\027\025\022\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\230\215\230.)Tj /T1_2 1 Tf 0.01 Tc 0.1 Tw 8 0 0 8 42.5596 319.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.105 Tw 8.575 0 Td ( \021\025\027\240\032\005\213\022\025\025\013\027 \033\031\021\032\027\255\ \030\027\025\022\t \033\032\t\026\031\235 \n\022\213\n\022, 4D-\n\031\025\ \006\027\033\006\022\t, \n\031\025\023\032\031\f\017 \033\031\021\032\027\ \255\030\027\025\022\235, \026\025\031\b\031\204\023\020\033\025\031\027\ \200\022\032\r\032\b\022\007\027\024\n\031\027 )Tj 0.023 Tw -8.58 -1.2 Td (\f\027\007\027\025\022\027, \031\b\025\027\024\023\032\027\f\017\025\013\ \027 \032\020\025\027\025\022\t, \033\020\032\020\032\027\n\023\020\f\017\ \025\031\027 \030\032\027\025\022\032\031\021\020\025\022\027, \204\023\020\ \033\013 \026\027\030\022\006\022\025\024\n\031\235 \204\021\020\n\r\020\ \006\022\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.024 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5.2( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.014 Tc -0.035 Tw 8.982 0 Td ( \222\031\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \202\035\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\202., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \207\026\030\007\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\203., \003\024\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\025.\224., \210\r\004\017\027\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\212.\200.,)14( )]TJ 0.021 Tc -8.987 -1.2 Td (\212\t\n\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \025\024\030\032\031\022)Tj /Span<>> BDC ( )Tj EMC (\204.\222. \222\023\024\030\027\t\036 \r\024\023\030\024\f\t \007\017\026\ \020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\220\021\026\023\027\024\020\024 \b\017\030\031\030\020\ \017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\r\027\036\002\030\033\001\017\027\027\t\n\017)21( )]TJ 0.02 Tc -0.034 Tw 0 -1.2 TD [(\030\026\027\036\027\017\016\n\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017. )]TJ /T1_1 1 Tf -0.02 Tw 11.605 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.034 Tw [( )0.6(2026; )0.6(\021.)]TJ /Span<>> BDC ( )Tj EMC 11.854 0 Td [(25, )0.5(\223)]TJ /Span<>> BDC ( )Tj EMC 2.543 0 Td [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC 1.937 0 Td [(101\226115. )0.6(https://doi.org/10.33878/2073-7556-2026-25-1-101-115)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 65.6456 222.0332 Tm [(Contr)20(ov)12(er)20(sial issues of\022)-23.3(diagnosis and multi-stage sur)31(gical )]TJ 0.294 -1.167 Td [(tr)31(eatment in\022)-23.3(patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 176.5293 Tm [(Dmitrii\022)-23.2(A)-31(.\022)-23.3(Sur)20(ov)]TJ 8.162 0 0 8.162 131.1041 181.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 135.74 176.5293 Tm [(, Roman\022)-23.2(V)62(.\022)-23.3(Esele)11(vich)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 251.5308 181.1913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 262.8514 176.5293 Tm [(, P)20(av)12(el\022)-23.3(A)-30.9(.\022)-23.3(Alimov)]TJ 0 Tw 8.162 0 0 8.162 359.9802 181.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 364.6162 176.5293 Tm [(, Oleg\022)-23.2(V)62(.\022)-23.3(Balur)21(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 455.6969 181.1913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 467.0175 176.5293 Tm (, )Tj -30.321 -1.143 Td [(V)31(aler)-31(y\022)-23.2(N.\022)-23.3(Rum)21(y)21(antse)11(v)]TJ 8.162 0 0 8.162 166.4822 165.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 171.1181 160.5293 Tm [(, Ser)31(gey\022)-23.2(N.\022)-23.3(Bar)31(dak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 292.9991 165.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 297.635 160.5293 Tm [(, K)41(onstantin\022)-23.2(Y)40(u.\022)-23.3(Z)21(otov)]TJ 0 Tw 8.162 0 0 8.162 419.9073 165.1913 Tm (1)Tj 14 0 0 14 424.5432 160.5293 Tm (, )Tj -27.287 -1.143 Td [(Dmitrii\022)-23.2(V)62(.\022)-23.3(Obchinnik)11.1(ov)]TJ 8.162 0 0 8.162 167.6434 149.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 172.2794 144.5293 Tm [(, Denis\022)-23.2(A)-31(.\022)-23.3(Dymnik)11.1(ov)]TJ 0 Tw 8.162 0 0 8.162 286.5857 149.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 291.2216 144.5293 Tm [(, Mikhail\022)-23.2(S.\022)-23.3(K)41(or)20(zh)11(uk)]TJ 0 Tw 8.162 0 0 8.162 404.6322 149.1913 Tm (1)Tj 5.83 0 0 5.83 42.5197 130.19 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 126.86 Tm [(S.M.\022)-23.3(Kir)20(ov Militar)-30.9(y Medical Academ)21(y \(Akademika Lebede)11(v)10(a\022)-23.2(st., 6J, Saint P)10(eter)20(sbur)31(g, 1)138(9)79.9(40)25.1(44,Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 118.19 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 114.86 Tm [(St. P)10(eter)20.1(sbur)31(g Medical and social institute \(K)41(ondr)21.1(atie)11(v)10(sky A)20(v)12(e., 7)58.1(2, let)-20(ter A)-30.9(, St. P)10(eter)20(sbur)31(g, 1)138(9)46(5)35(2)46(7)127(1)69(, Russia\))]TJ /T1_1 1 Tf 0.057 Tw 9 0 0 9 90.7087 96.3561 Tm [(AIM: to )0.5(assess the )0.5(adherence of )0.5(surg)12(eons to v)16(ar)-36.9(ious methods )0.5(of diagnosis and surgical treatment of )0.5(patients with )]TJ 0.023 Tw 0 -1.111 TD 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Col)29.6(or)-24.4(ec)-16.4(t)14.6(al anast)16.6(omo)16.5(t)-32.4(ic leak)]TJ 0 Tc 0 Tw 25.986 0 Td (-)Tj 0.195 Tw -27.286 -1.25 Td [(a)-17(ge: a)]TJ /Span<>> BDC ( )Tj EMC [(nar)-24(r)-33(a)15(t)-31.9(i)-16(ve r)-24(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(def)-27.9(ini)-24(t)-32(ions, gr)-33(ading sy)-13(stems, and con)]TJ 0 Tw (-)Tj 0.27 Tw T* (sequences of)Tj /Span<>> BDC ( )Tj EMC [(leak)-10(s. )]TJ /T1_1 1 Tf [(F)27(ront Surg)]TJ /T1_0 1 Tf [(. 2024;11:1371567. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/)Tj T* [(fsur)-32(g.2024.1371567)]TJ 0 0 0 1 k /GS1 gs -0.039 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Almut)15.1(air)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(FM. R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(Biomar)-23.9(k)10(er)-10(s in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(Anast)17.1(omo)17(t)-32(ic )]TJ 0.194 Tw -1.796 -1.25 Td [(L)35(eak)-17(a)-17(ge Af)-27.9(ter Col)30(or)-24(ec)-16(t)15.1(al Sur)-32(ger)-24(y: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-13(stema)15(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-)]TJ 0 Tw T* [(Anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 3.827 0 Td (Cureus)Tj /T1_0 1 Tf 0.023 Tw [(. 2024;16\(6\):e62432. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.62432)]TJ 0 0 0 1 k /GS1 gs 0.304 Tw -3.827 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tum)10(pf)]TJ /Span<>> BDC ( )Tj EMC 3.383 0 Td [(M, )0.5(Kl)-31(inge)]TJ /Span<>> BDC ( )Tj EMC [(U, )0.5(W)-16(ilms)]TJ /Span<>> BDC ( )Tj EMC 8.718 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Changes )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )0.5(e)-18(xtr)-32.9(a)]TJ 0 Tw (-)Tj 0.009 Tc 0.349 Tw -13.897 -1.25 Td [(cell)35.3(ul)-15.8(ar ma)15.3(tr)-36.7(ix as a)]TJ /Span<>> BDC ( )Tj EMC [(r)-36.8(isk f)16.2(a)-16.7(c)-15.8(t)17.3(or for anast)17.3(omo)17.2(t)-31.8(ic leak)-16.8(a)-16.7(ge af)-27.7(ter)9( )]TJ 0 Tc 0.109 Tw T* [(l)-16(ar)-32(ge bo)-14(wel sur)-32(ger)-24(y. )]TJ /T1_1 1 Tf 0 Tw [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.109 Tw [(. 2005;137\(2\):229\22634. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* [(sur)-32(g.2004.07.011)]TJ 0 0 0 1 k /GS1 gs 0.051 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ed)-16(omsk)-15.9(is)]TJ /Span<>> BDC ( )Tj EMC [(P, Goudber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(MR, Sp)32(ar)-24(r)-24(ebo)-16(om)]TJ /Span<>> BDC ( )Tj EMC [(CL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)15(tr)-36.9(ix me)-12(t)15(all)30(o)]TJ 0 Tw (-)Tj -0.021 Tw -1.796 -1.25 Td [(p)25(r)-32(o)17(teinase-9 in r)-24(el)-15.9(a)15(t)-32(ion t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-23.9(t)-13(h com)10(pl)-31(ica)15.1(t)-32(ions af)-28(ter col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.068 Tw T* [(t)15(al sur)-31.9(ger)-24(y: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-23.9(ev)-16(iew. )]TJ /T1_1 1 Tf [(Int J )0.5(Colorectal )0.5(Dis.)]TJ /T1_0 1 Tf ( 2021;36\(1\):1\226)Tj 0.023 Tw T* [(10. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-020-03724-6)Tj 0 0 0 1 k /GS1 gs 0.087 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(uo)]TJ /Span<>> BDC ( )Tj EMC [(J, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(H, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oxid)42(a)15(t)-32(i)-16(ve S)15.1(tr)-24(ess L)35(evel as a)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-24(edic)-16(t)17.1(or )]TJ 0.23 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Anast)17.1(omo)17(t)-32(ic L)35(eak)-17(a)-17(ge af)-28(ter R)13(ec)-16(t)15(al Sur)-32(ger)-23.9(y. )]TJ /T1_1 1 Tf [(Mediators Inf)-22(lamm.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;2021:9968642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2021/9968642)Tj /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7653 56.0378 Tm (100)Tj ET endstream endobj 1000 0 obj <>/Border[0 0 0]/H/N/Rect[190.976 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<>/Border[0 0 0]/H/N/Rect[303.307 688.512 368.595 679.216]/Subtype/Link/Type/Annot>> endobj 1011 0 obj <>/Border[0 0 0]/H/N/Rect[440.523 658.512 514.146 649.056]/Subtype/Link/Type/Annot>> endobj 1012 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 628.512 524.409 619.056]/Subtype/Link/Type/Annot>> endobj 1013 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 618.512 360.443 609.216]/Subtype/Link/Type/Annot>> endobj 1014 0 obj <>/Border[0 0 0]/H/N/Rect[330.503 578.512 427.975 569.216]/Subtype/Link/Type/Annot>> endobj 1015 0 obj <>/Border[0 0 0]/H/N/Rect[387.359 548.512 464.815 539.216]/Subtype/Link/Type/Annot>> endobj 1031 0 obj <> endobj 1030 0 obj <> endobj 1029 0 obj <> endobj 1028 0 obj <> endobj 1027 0 obj <> endobj 1026 0 obj <> endobj 1025 0 obj <> endobj 1024 0 obj <> endobj 1023 0 obj <> endobj 1022 0 obj <> endobj 1021 0 obj <> endobj 1020 0 obj <> endobj 1019 0 obj <> endobj 1018 0 obj <> endobj 1017 0 obj <> endobj 1016 0 obj <> endobj 996 0 obj [1032 0 R 1033 0 R 1034 0 R 1035 0 R 1036 0 R 1037 0 R 1038 0 R 1039 0 R] endobj 997 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.167 Tw 10 0 0 10 42.5197 700.4739 Tm (\210\023\030\036\007\036\035\036\027\017\036 \031\030\024\r\027\016 \f\r\ \024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\026\ , \204\212\202 )Tj 0.09 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\200\207\212 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\n \023\036\030\017\024\007\036 \n\024\032\036\021 )Tj 0.034 Tw T* (\f\035\031\032\017\021\034 \024\f\027\024\r\024\005 \007\035\016 \023\036\ \030\f\024\027\017\235\017\006\017\030\024\r\026\027\027\024\005 \021\026\ \022\021\017\022\017 )Tj 0.004 Tw T* (\r\036\007\036\027\017\016 \023\026\006\017\036\027\021\024\r \020\030\031\ \023\023\t \r\t\f\024\022\024\020\024 \030\017\f\022\026 \203\202, \r\022\ \035\033)Tj 0 Tw (-)Tj 0.282 Tw T* (\004\026\016 \031\f\017\035\036\027\027\t\005 \n\024\027\017\021\024\030\ \017\027\020, \026\020\030\036\f\f\017\r\027\t\005 \022\024\027\021\030\024\ \035\034 )Tj 0.028 Tw 0 -1.218 TD (\r\027\031\021\030\017\002\030\033\001\027\024\020\024 \007\026\r\035\036\ \027\017\016, \022\024\030\030\036\022\006\017\033 \024\022\f\017\007\026\ \021\017\r\027\024)Tj 0 Tw (-)Tj 0.101 Tw 0 -1.218 TD [(\020\024 )0.5(\f\021\030\036\f\f\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.511 0 Td [(\f\r\024\036\r\030\036\n\036\027\027\024\036 )0.6(\r\t\023\024\035\027\036\027\017\036 )0.5(\007\017\026\020\027\024\f\021\017)]TJ 0 Tw (-)Tj -5.511 -1.218 Td (\004\036\f\022\024\005 \017\035\017 \035\036\004\036\002\027\024\005 \030\ \036\035\026\023\026\030\024\021\024\n\017\017.)Tj 0.317 Tw T* [(\200 \n\027\024\020\024\235\026\022\021\024\030\027\024\005 \n\024\007\036\ \035\017 )0.5(\027\036\026\r\017\f\017\n\t\n\017 \023\030\036\007\017\022)]TJ 0 Tw (-)Tj 0.47 Tw T* [(\021\024\030\026\n\017 )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\001\r\024\r )0.5(\021\024\035\f\021\024\022\017\001\036\004\027\024\020\024 )]TJ 0.199 Tw 0 -1.218 TD (\026\027\026\f\021\024\n\024\026 \016\r\035\016\035\017\f\034 \031\030\024\ \r\036\027\034 \f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\ \024)Tj 0 Tw (-)Tj 0.171 Tw 0 -1.218 TD (\035\017\027\026, \r\036\035\017\004\017\027\026 \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\027\021\030\026\006\017\016 \204\212\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 )Tj 0.109 Tw 0 -1.218 TD (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017. \ \025\026\032\007\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\024\022\026\026\021\036\035\036\005 )Tj 0.18 Tw 0 -1.218 TD (\007\036\n\024\027\f\021\030\017\030\024\r\026\035 \024\021 \031\n\036\030\ \036\027\027\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\036\005 \007\017\f\022\030\017)Tj 0 Tw (-)Tj 0.09 Tw 0 -1.218 TD (\n\017\027\017\030\031\033\013\036\005 \f\023\024\f\024\002\027\024\f\021\ \017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\b \022\024\n\002\017\027\026\006\017\016 \024\002\036\f\023\036)Tj 0 Tw (-)Tj 0.351 Tw 0 -1.218 TD (\004\017\r\026\035\026 \002\024\035\036\036 \r\t\f\024\022\031\033 \021\024\ \004\027\024\f\021\034 \023\030\024\020\027\024\017\030\024\r\026\027\017\ \016 )Tj 0.201 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \024\021\007\036\035\034\ \027\t\b \n\026\030\022\036)Tj 0 Tw (-)Tj 0.049 Tw 0 -1.218 TD (\030\024\r. \210\022\024\027\004\026\021\036\035\034\027\026\016 \024\006\ \036\027\022\026 \022\035\017\027\017\004\036\f\022\024\005 \027\026\004\ \017\n\024\f\021\017 )Tj 0.092 Tw T* [(\023\030\036\007\035\024\032\036\027\027\t\b )0.6(\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b )0.6(\017\027\007\017\022\026\021\024\030\024\r )0.5(\021\030\036\002\031)]TJ 0 Tw (-)Tj 0.012 Tw 0 -1.218 TD (\036\021 \023\030\024\f\023\036\022\021\017\r\027\024\005 \r\026\035\017\ \007\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \022\030\031\023\027\t\b \027\036\026)Tj 0 Tw (-)Tj 0.158 Tw 0 -1.218 TD (\r\017\f\017\n\t\b \r\t\002\024\030\022\026\b \023\026\006\017\036\027\021\ \024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\020\024 \f\030\026\r\027\036\027\017\016 )Tj 0.043 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\f\031\013\036\f\021\r\031\033\013\017\n\017 )0.5(\002\017\024\n\026\030\022\036\030\027\t\n\017 \017)]TJ /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\030\026\007\017\024)Tj 0 Tw (-)Tj T* (\035\024\020\017\004\036\f\022\017\n\017 \n\024\007\036\035\016\n\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_2 1 Tf -0.026 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf [( \206)-10.5(\r)-4.2(\016)6(\022)1.7(\240)1.2(\031)6(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)29.4(\206)93.8(.)7.9(, )]TJ 0 Tw T* [(\216)98(\r)23.8(\f)3.3(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.5(.)27.5(\202)8.6(.)7.8(, \216)98(\r)23.8(\f)3.3(\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, \003)-17.3(\f)9.6(\022)-4.3(-)14.4(\207)10.9(\020)0.9(\030)1.9(\027)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)29.3(\216)122(.)]TJ /T1_2 1 Tf 0.4 Tw T* [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.2(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.6(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf [( \206)-10.4(\r)-4.2(\016)6(\022)1.7(\240)1.1(\031)6(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)29.3(\206)93.9(.)7.8(, )]TJ 0 Tw T* [(\216)98(\r)23.8(\f)3.3(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)7.8(, \001)5.9(\r)-4.3(\032)12.2(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\207)27.7(.)20.1(\215)19.4(.)]TJ /T1_2 1 Tf 0.018 Tc -0.018 Tw T* [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 11.349 0 Td [( \003)-17.3(\f)9.6(\022)-4.3(-)14.4(\207)10.9(\020)0.9(\030)1.9(\027 \205)-2.1(.)29.3(\216)92.9(, \216)98(\r)23.8(\f)3.4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)]TJ /T1_2 1 Tf 0.002 Tc -0.002 Tw -11.349 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \206)-10.5(\r)-4.2(\016)6(\022)1.7(\240)1.1(\031)6.1(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)29.3(\206)93.9(.)7.8(, \003)-17.2(\f)9.6(\022)-4.3(-)14.3(\207)10.9(\020)0.9(\030)1.9(\027)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)29.4(\216)122(.)]TJ /T1_2 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf 0.756 Tw [( )0.5(\206)-10.5(\r)-4.2(\016)6.1(\022)1.7(\240)1.1(\031)6(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC 14.282 0 Td [(\202)8.6(.)29.3(\206)93.9(.)7.8(, )0.6(\216)98(\r)23.8(\f)3.3(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 5.888 0 Td [(\215)19.4(.)27.5(\202)8.6(.)7.8(, )]TJ -0.122 Tc 0.122 Tw -20.17 -1.218 Td [(\003)-139.3(\f)-112.4(\022)-126.3(-)-107.6(\207)-111.1(\020)-121.1(\030)-120.1(\027)]TJ /Span<>> BDC 3.678 0 Td ( )Tj EMC [(\205)-124.1(.)-92.7(\216.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.678 -2.436 Td (AUTHOR CONTRIBUTIONS)Tj /T1_2 1 Tf -0.083 Tw T* [(S)7(t)-12.8(ud)-10.9(y c)3.7(o)0.8(nce)-0.7(p)-12.3(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n)15.4(:)]TJ /T1_4 1 Tf [( K)12.8(a)2.3(h)6.2(r)7.7(a)-0.8(m)-1.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.6(z)-17.4(i)9.1(b)-5.9(o)2.3(y)-2.4(z)12.4(o)-7.8(d)1.9(a)-14(, )]TJ 1.231 Tw T* [(M)5.2(a)2.2(h)5.2(m)4.3(a)-4.5(d)-1.4(s)9.6(h)1.9(o)3.2(h)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)2.9(o)-0.6(v)33.6(, A)17.1(f)-23.8(z)12.9(al)-28.6(s)9.6(h)1.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)3(o)-0.6(v)33.6(, )]TJ -0.006 Tc 0.006 Tw T* [(S)9.8(u)-1.4(k)-0.7(hr)-3.5(o)-4(b)]TJ /Span<>> BDC 3.152 0 Td ( )Tj EMC [(G)-7.4(.)]TJ /Span<>> BDC 1.041 0 Td ( )Tj EMC [(A)-2.4(l)-1.7(i)-10.5(-)-3.4(Za)-10.5(d)-7(e)]TJ /T1_2 1 Tf 0 Tc 3.099 Tw 19.051 47.494 Td [(D)-1.6(a)-8.4(t)-27.7(a c)3.7(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g)9(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0.903 Tw T* [(K)12.8(a)2.2(h)6.2(r)7.7(a)-0.8(m)-1.1(o)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.6(z)-17.4(i)9.1(b)-5.8(o)2.3(y)-2.5(z)12.4(o)-7.8(d)1.9(a)-14(, A)17.1(f)-23.8(z)12.9(al)-28.6(s)9.6(h)1.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(. G)4.9(u)2.8(l)2.9(o)-0.6(v)33.7(, )]TJ -0.005 Tc 0.005 Tw T* [(Zoi)4.4(r)-15.7(s)4.6(h)-3.1(o)]TJ /Span<>> BDC 2.825 0 Td ( )Tj EMC (M.)Tj /Span<>> BDC 1.172 0 Td ( )Tj EMC [(N)3.6(u)1.1(r)-19.6(z)7.4(o)-12.8(d)-3.1(a)]TJ /T1_2 1 Tf -0.002 Tc -0.035 Tw -3.997 -1.218 Td [(S)5(t)-29.7(a)-10.4(t)-39.4(i)0.7(s)-21.9(t)-39.4(i)3.2(c)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_4 1 Tf 0 Tc -0.037 Tw 7.206 0 Td [( S)15.8(u)4.6(k)5.3(h)6.2(r)2.4(o)2(b)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.3(i)-4.6(-)2.6(Z)5.6(a)-4.5(d)-1(e)-20.1(, A)17.1(f)-23.7(z)12.9(al)-28.6(s)9.6(h)1.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)2.9(o)-0.6(v)]TJ /T1_2 1 Tf -0.009 Tc 0.009 Tw -7.206 -1.218 Td [(W)-5.9(r)-57(i)-15(t)-46.4(i)-1.9(n)-10.9(g:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.318 0 Td [( K)12.8(a)2.2(h)6.2(r)7.8(a)-0.8(m)-1.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.5(z)-17.5(i)9.2(b)-5.9(o)2.3(y)-2.5(z)12.4(o)-7.8(d)1.9(a)-14(, S)15.9(u)4.6(k)5.3(h)6.2(r)2.4(o)2(b)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.7(l)4.3(i)-4.6(-)2.6(Z)5.6(a)-4.5(d)-1(e)]TJ /T1_2 1 Tf 0.006 Tc -0.006 Tw -3.318 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc -0.118 Tw 3.238 0 Td [( K)12.8(a)2.2(h)6.2(r)7.7(a)-0.8(m)-1.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.6(z)-17.4(i)9.1(b)-5.9(o)2.3(y)-2.4(z)12.3(o)-7.7(d)1.9(a)-14(, M)5.2(a)2.2(h)5.2(m)4.3(a)-4.5(d)-1.5(s)9.6(h)1.9(o)3.2(h)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)2.9(o)-0.6(v)33.6(, )]TJ -0.006 Tc 0.006 Tw -3.238 -1.218 Td [(S)9.8(u)-1.4(k)-0.7(hr)-3.5(o)-4(b)]TJ /Span<>> BDC 3.152 0 Td ( )Tj EMC [(G)-7.4(.)]TJ /Span<>> BDC 1.041 0 Td ( )Tj EMC [(A)-2.4(l)-1.7(i)-10.6(-)-3.3(Za)-10.5(d)-7(e)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -4.193 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_2 1 Tf 0.007 Tw T* (\217\031\017\002\024\005\024\007\026 \025\026\b\030\026\n\024\027 \217\ \031\017\002\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030 )Tj 0.329 Tw T* (\022\026\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b\ \002\024\035\036\027\036\005 \2231 \017\n\036\027\017 \026\022\026)Tj 0 Tw (-)Tj 0.198 Tw T* (\007\036\n\017\022\026 \025.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\031\030\002\024\027\024\r\026, \206\210\211 \253\221\026\007\032\017\ \022\f\022\017\005 \020\024\f\031\007\026\030)Tj 0 Tw (-)Tj 0.173 Tw 0 -1.218 TD (\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\022\017\005 \031\ \027\017\r\036\030\f\017\021\036\021 \017\n\036\027\017 \202\002\031 \026\ \035\017 )Tj 0 Tw 0 -1.218 TD (\017\002\027\017 \222\017\027\024\273; ORCID 0000-0001-8381-0364)Tj 0.083 Tw 0 -1.218 TD (\206\031\035\024\r \204\026\b\n\026\007\001\024\b \025\031\030\002\024\027\ \026\035\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f)Tj 0 Tw (-)Tj 0.271 Tw 0 -1.218 TD (\f\024\030 \022\026\235\036\007\030\t \021\024\023\024\020\030\026\235\017\ \004\036\f\022\024\005 \026\027\026\021\024\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026)Tj 0 Tw (-)Tj 0.16 Tw 0 -1.218 TD (\021\017\r\027\024\005 \b\017\030\031\030\020\017\017 \017\n\036\027\017\ \023\030\024\235\036\f\f\024\030\026 \204.\025.)Tj /Span<>> BDC ( )Tj EMC (\025\026\030\017\n\024\r\026 )Tj 0.603 Tw 0 -1.218 TD (\206\210\211 \253\221\026\007\032\017\022\f\022\017\005 \020\024\f\031\007\ \026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\022\017\005\ )Tj 0.458 Tw 0 -1.218 TD (\031\027\017\r\036\030\f\017\021\036\021 \017\n\036\027\017 \202\002\031\ \026\035\017 \017\002\027\017 \222\017\027\024\273; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0001-5151-937X)Tj -0.029 Tw T* (\206\031\035\024\r \202\235\026\035\001\024 \202\n\017\030\001\024\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\024\004\027\t\005 \026\f\023\017\030\026\027\021 \022\026)Tj 0 Tw (-)Tj -0.011 Tw 0 -1.218 TD (\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\ \035\036\027\036\005 \2231 \017\n\036\027\017 \026\022\026\007\036\n\017\ \022\026 )Tj 0.159 Tw 0 -1.218 TD (\025.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\031\030\002\024\027\024\r\026, \206\210\211 \253\221\026\007\032\017\ \022\f\022\017\005 \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \ )Tj -0.049 Tw 0 -1.218 TD (\n\036\007\017\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\ \036\021 \017\n\036\027\017 \202\002\031 \026\035\017 \017\002\027\017 \222\ \017\027\024\273; )Tj 0 Tw T* (ORCID 0009-0002-0859-2939)Tj -0.025 Tw T* (\203\031\030\024\007\026 \003\024\017\030\001\024 \204\017\030\026\b\n\026\ \007)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 \022\026\235\036\007\030\t \ )Tj 0.083 Tw T* (\021\024\023\024\020\030\026\235\017\004\036\f\022\024\005 \026\027\026\021\ \024\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\005 \b\017\030\031\030\020\017\017\ )Tj 0.076 Tw T* [(\017\n\036\027\017 )0.6(\023\030\024\235\036\f\f\024\030\026 )0.5(\204.\025.)]TJ /Span<>> BDC ( )Tj EMC 10.303 0 Td [(\025\026\030\017\n\024\r\026, )0.5(\206\210\211 )0.6(\253\221\026\007\032\017\022\f\022\017\005 )]TJ 0.36 Tw -10.303 -1.218 Td (\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021 \017\n\036\027\ \017 )Tj 0 Tw T* (\202\002\031 \026\035\017 \017\002\027\017 \222\017\027\024\273; ORCID 0\ 009-0004-8029-9803)Tj 0.193 Tw T* (\202\035\017-\003\026\007\036 \222\031\b\030\024\002 \206\026\235\235\026\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tw (-)Tj -0.011 Tw T* (\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\ \035\036\027\036\005 \2231 \017\n\036\027\017 \026\022\026\007\036\n\017\ \022\026 )Tj 0.159 Tw T* (\025.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\031\030\002\024\027\024\r\026, \206\210\211 \253\221\026\007\032\017\ \022\f\022\017\005 \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \ )Tj -0.049 Tw T* (\n\036\007\017\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\ \036\021 \017\n\036\027\017 \202\002\031 \026\035\017 \017\002\027\017 \222\ \017\027\024\273; )Tj 0 Tw T* (ORCID 0000-0002-2456-7509)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(K)-16(ahr)-33(amon R. Ruziboyzod)42.1(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8381-0364)Tj T* [(Mahmadshoh K. Gul)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5151-937X)Tj T* [(Afzalsho A. Gul)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0002-0859-2939)Tj T* [(Z)25(oir)-10(sho M. Nur)-23.9(zod)42(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-8029-9803)Tj T* [(Sukhr)-32(ob G. Al)-30.9(i-Z)10(ade)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2456-7509)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 188.9979 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.302 Tw 8 0 0 8 42.5197 176.1632 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gessler)Tj /Span<>> BDC ( )Tj EMC [(B, Er)-37(ik)-9.9(sson)]TJ /Span<>> BDC ( )Tj EMC [(O, Angene)-12(te)]TJ /Span<>> BDC ( )Tj EMC [(E. Dia)-17(gnosis, tr)-23.9(ea)15(tment, and )]TJ 0.325 Tw -1.296 -1.25 Td (consequences of)Tj /Span<>> BDC ( )Tj EMC [(anast)17.1(omo)17(t)-32(ic leak)-16.9(a)-17(ge in col)30(or)-23.9(ec)-16(t)15(al sur)-31.9(ger)-24(y. )]TJ /T1_4 1 Tf 0 Tw (Int )Tj 0.315 Tw 0 -1.25 TD (J Colorectal Dis. )Tj /T1_2 1 Tf [(2017;32\(4\):549\226556. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-016-)Tj T* (2744-x)Tj 0 0 0 1 k /GS1 gs -0.062 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\214\036\002\036\007\034\022\024)Tj /Span<>> BDC ( )Tj EMC (\204. \222., \206\024\030\007\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\222., \202\035\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\233.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \205\026\022\021\024\030\t \030\017\f\022\026 )Tj 0.08 Tw -1.296 -1.25 Td (\030\026\r\017\021\017\016 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\ \024 \026\027\026\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024)Tj 0 Tw (-)Tj 0.171 Tw T* [(\007\t \036\036 \023\030\024\235\017\035\026\022\021\017\022\017: \030\036\ \021\030\024\f\023\036\022\021\017\r\027\024\036 \022\024\020\024\030\021\ \027\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036. )]TJ /T1_4 1 Tf 0.052 Tw T* (\020\016\031\021\020\t \200\022\032\r\032\b\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\025\n\031\f\031\b\022\t)Tj /T1_2 1 Tf [(. 2022;12\(2\):17\22627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17650/2)Tj T* (686)Tj /Span<>> BDC (-)Tj EMC (9594)Tj /Span<>> BDC (-)Tj EMC (2022)Tj /Span<>> BDC (-)Tj EMC (12)Tj /Span<>> BDC (-)Tj EMC (2)Tj /Span<>> BDC (-)Tj EMC (17)Tj /Span<>> BDC (-)Tj EMC (27)Tj 0 0 0 1 k /GS1 gs 0.004 Tw [( / L)35(ebedko)]TJ /Span<>> BDC ( )Tj EMC [(M.S., Gor)-24(deev)]TJ /Span<>> BDC ( )Tj EMC [(S.S., Al)-30.9(iev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (E.V., )Tj 0.123 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk )0.5(f)16(a)-17(c)-16(t)17(or)-10(s for col)30(or)-24(ec)-16(t)15.1(al anast)17(omo)17(t)-32(ic )0.5(leak)-17(a)-17(ge and )0.5(me)-12(t)-13(hods )]TJ 0.154 Tw 29.055 11.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(i)-24(ts p)25(r)-24(event)-31.9(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(e)-12(tr)-32(ospec)-16(t)-32(i)-15.9(ve cohor)-22(t stud)17(y. )]TJ /T1_4 1 Tf [(P)15(elvic surg)12.1(er)-43(y and )]TJ 0 Tw T* (oncology)Tj /T1_2 1 Tf 0.099 Tw [(. 2022;12\(2\):17\22627. \(in Russ.\). d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17650/2686-9594-)Tj T* (2022-12-2-17-27)Tj 0 0 0 1 k /GS1 gs 0.314 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(eng)16(yu W)22(ei, S)-16(i W)16(u, Jiale Gao, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Def)-28(ini)-24(t)-32(ion and gr)-33(ading )]TJ 0.013 Tc 0.459 Tw -1.296 -1.25 Td [(o)0.5(f)]TJ /Span<>> BDC 0.84 0 Td ( )Tj EMC [(a)0.5(n)0.6(a)0.5(s)0.5(t)17.6(o)0.5(m)0.5(o)17.6(t)-31.5(i)0.6(c)0.5( l)0.5(e)0.6(a)0.5(k)-16.4(a)-16.5(g)0.5(e)0.6( f)0.5(o)0.5(l)0.6(l)30.5(o)-13.5(w)0.6(i)0.5(n)0.6(g)0.5( r)-36.5(i)0.6(g)0.5(h)0.6(t)0.5( h)0.5(e)0.6(m)0.5(i)0.6(c)0.5(o)0.5(l)0.6(e)0.5(c)-15.5(t)17.6(o)0.5(m)0.6(y)0.5(.)0.5( )]TJ /T1_4 1 Tf -0.013 Tw [(B)0.6(J)0.5(S)]TJ /T1_2 1 Tf 0 Tc 0 Tw 26.502 0 Td (. )Tj 0.023 Tw -27.342 -1.25 Td [(2024;111\(7\):155. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/bjs/znae155)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.385 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td (Bona)Tj /Span<>> BDC ( )Tj EMC [(D, Danell)-31.3(i)]TJ /Span<>> BDC ( )Tj EMC [(P, S)-16.3(oz)-24.3(zi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. C-r)-24.3(ea)-17.3(c)-16.3(t)-32.3(i)-16.3(ve P)34.7(r)-32.3(o)16.7(tein and)10( )]TJ 0 Tc 0.226 Tw -1.327 -1.25 Td [(P)35(r)-32(o)-16(cal)16(c)-23.9(i)-24(t)17(onin )0.5(L)35(evels )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 10.043 0 Td [(P)35(r)-24(edic)-15.9(t )0.5(Anast)17(omo)17(t)-31.9(ic )0.5(L)35(eak )0.5(Af)-27.9(ter )0.5(Col)30.1(or)-24(ec)-16(t)15(al )]TJ 0.135 Tw -10.043 -1.25 Td [(Sur)-32(ger)-23.9(y: Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_4 1 Tf (J Gastrointest Surg.)Tj /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2023;27\(1\):166\226179. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-022-05473-z)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8518 56.0378 Tm (99)Tj ET endstream endobj 1032 0 obj <>/Border[0 0 0]/H/N/Rect[192.966 163.459 263.622 154.003]/Subtype/Link/Type/Annot>> endobj 1033 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 153.459 64.8875 144.163]/Subtype/Link/Type/Annot>> endobj 1034 0 obj <>/Border[0 0 0]/H/N/Rect[225.71 113.459 263.622 104.003]/Subtype/Link/Type/Annot>> endobj 1035 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 103.459 131.415 94.1632]/Subtype/Link/Type/Annot>> endobj 1036 0 obj <>/Border[0 0 0]/H/N/Rect[424.519 173.459 496.063 164.003]/Subtype/Link/Type/Annot>> endobj 1037 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 163.459 330.224 154.163]/Subtype/Link/Type/Annot>> endobj 1038 0 obj <>/Border[0 0 0]/H/N/Rect[348.933 133.459 418.676 124.163]/Subtype/Link/Type/Annot>> endobj 1039 0 obj <>/Border[0 0 0]/H/N/Rect[361.381 93.4593 458.204 84.1632]/Subtype/Link/Type/Annot>> endobj 1047 0 obj <> endobj 1046 0 obj <> endobj 1045 0 obj <> endobj 1044 0 obj <> endobj 1043 0 obj <> endobj 1042 0 obj <> endobj 1041 0 obj <> endobj 1040 0 obj <> endobj 995 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.086 Tw 10 0 0 10 70.8661 724.8299 Tm (\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\017\035\036\027\027\024\n \030\026\f\023\026\007\036 \030\036\035\ \024\020\024 \022\024\035\035\026\020\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026)Tj 0 Tw (-)Tj 0.618 Tw 0 -1.218 TD (\f\021\024\n\024\026. \025\035\026\f\f\017\004\036\f\022\017\036 \017\f\ \f\035\036\007\024\r\026\027\017\016 \017\n\036\027\036\027\017\005 )Tj 0.19 Tw T* (\r\027\036\022\035\036\021\024\004\027\024\020\024 \n\026\021\030\017\022\ \f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\016\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\n )Tj 0.062 Tw T* [(\022\017\001\036\004\027\017\022\036 )0.6(\023\024\022\026\026\035\017, )0.5(\004\021\024 )0.5(\007\017\f\002\026\035\026\027\f )0.6(\n\036\032\007\031 )0.5(\f\017\027\021\036\024\n )]TJ 0.124 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.874 0 Td [(\007\036\020\030\026\007\026\006\017\036\005 )0.6(\022\024\035\035\026\020\036\027\026 )0.5(\026\f\f\024\006\017\017\030\024\r\026\027 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 17.145 0 Td (\023\024\r\t\001\036\027)Tj 0 Tw (-)Tj 0.039 Tw -18.019 -1.218 Td (\027\t\n \030\017\f\022\024\n \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \001\r\024\r [11]. \207\024\035\036\036 \027\024)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD [(\r\t\036 \007\026\027\027\t\036 \023\024\007\021\r\036\030\032\007\026\033\ \021 )0.5(\030\024\035\034 MMP-9 \017)]TJ /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \235\036\030)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD [(\n\036\027\021\024\r \n\026\021\030\017\022\f\027\024\020\024 )0.5(\030\036\n\024\007\036\035\017\030\024\r\026\027\017\016 )0.5(\022\026\022 \n\026\030\022\201\030\024\r )]TJ 0.502 Tw T* (\027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024 \021\036\ \004\036\027\017\016 \023\024\f\035\036 \022\024\035\024\030\036\022\021\ \026\035\034\027\t\b )Tj 0 Tw T* (\030\036\036\022\006\017\005 [12].)Tj 0.326 Tw T* (\200 \027\026\001\036\n \023\030\017\n\036\030\036 \017\n\036\027\027\024\ \f\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\035\017\027 )Tj 0.067 Tw T* (\024\022\026\026\035\f\016 \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \027\026\004\017\n\t\b \027\036\026\r\ \017\f\017\n\t\b )Tj -0.028 Tw 0 -1.218 TD (\023\030\036\007\017\022\021\024\030\024\r \203\202: OR 1,32 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\t\005 1 \n\022\n\024\035\034/\035 \017)Tj /Span<>> BDC ( )Tj EMC [(A)17.1(UC )]TJ 0.323 Tw 0 -1.218 TD (0,84 \f)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 80% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 )Tj 0.135 Tw 0 -1.218 TD (78% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\024\020\036)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (15 \n\022\n\024\035\034/\035. \233\021\017 \023\024\022\026\026\021\036\ \035\017 \f\024)Tj 0 Tw (-)Tj 0.255 Tw T* (\023\024\f\021\026\r\017\n\t \f)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\023\026\024\027\024\n A)17(UC, \022\024\021\024\030\t\005 \024\023\017\f\t\r\026\033\021 )]TJ 0.136 Tw T* [(\007\035\016 \253\022\035\026\f\f\017\004\036\f\022\017\b\273 )0.5(\002\017\024\n\026\030\022\036\030\024\r \(\222\217\207, )0.5(\215\025\221\) \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.2 Tw T* [(\021\r\036\030\032\007\026\033\021, )0.6(\004\021\024 )0.5(\n\026\030\022\201\030\t )0.5(\007\036\020\030\026\007\026\006\017\017 )0.6(\022\024\035\035\026\020\036\027\026 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.065 Tw T* (\021\036\027\006\017\026\035\034\027\024 \n\024\020\031\021 \026\027\016\ \021\034 \r\026\032\027\024\036 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\026\035\020\024\030\017\021\n\026\b )Tj 0 Tw T* (\030\026\027\027\036\020\024 \023\030\024\020\027\024\017\030\024\r\026\ \027\017\016.)Tj 0.063 Tw T* [(\203\036 \n\036\027\036\036 \027\026\004\017\n\t\n )0.5(\022\024\n\023\024\027\036\027\021\024\n \023\026\021\024\020\036\027\036\ \026 )0.5(\203\202 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.486 Tw T* [(\f\021\031\023\026\036\021 )0.5(\r\027\031\021\030\017\002\030\033\001\027\026\016 )0.6(\020\017\023\036\030\021\036\027\017\016. )0.6(\215\024\r\t\001\036\027\017\036 )]TJ 0.254 Tw T* [(\200\207\212 )0.5(\r\036\007\201\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 5.9 0 Td [(\f\027\017\032\036\027\017\033 )0.6(\f\023\035\026\027\b\027\017\004\036\f\022\024\005 )0.6(\023\036\030\235\031\017\017, )]TJ 0.105 Tw -5.9 -1.218 Td (\031\b\031\007\001\036\027\017\033 \n\017\022\030\024\006\017\030\022\031\ \035\016\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\036 \022\017\001\022\017, \030\024\f\021\031 )Tj 0.415 Tw T* (\r\027\031\021\030\017\023\030\024\f\r\036\021\027\024\020\024 \007\026\r\ \035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\b\026\027\017\004\036\f\022\024\005 \027\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\020\030\031\022\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\017\027\017\033 \001\r\024\r. \216\024\021\016 \f\023\036\006\017\026\ \035\034\027\t\b \030\026\002\024\021, \023\024)Tj 0 Tw (-)Tj 0.382 Tw T* (\f\r\016\013\201\027\027\t\b \200\207\212 \022\026\022 \022\024\035\017\004\ \036\f\021\r\036\027\027\024\n\031 \023\030\036\007\017\022\021\024\030\031\ )Tj 0.005 Tw T* (\203\202, \027\036\n\027\024\020\024, \007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\027\024\005 \020\017\023\036\030\021\ \036\027\017\017 )Tj 0.161 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\002\007\024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\ \017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n \007\036\n\024\027\f\021\030\017\030\031\033\021 )Tj 0.115 Tw T* [(\036\201 )0.5(\004\201\021\022\031\033 )0.5(\026\f\f\024\006\017\026\006\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 10.686 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\024\030\020\026\027)]TJ 0 Tw (-)Tj 0.081 Tw -10.686 -1.218 Td (\027\024\005 \007\017\f\235\031\027\022\006\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\016\n\017. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\005 \n\024\007\036\035\017 )Tj 0.115 Tw T* (\200\207\212)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (15 \n\n \030\021. \f\021. \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017 )Tj 0.292 Tw T* [(\f\024\023\030\024\r\024\032\007\026\035\024\f\034 A)17.1(UC 0,78, \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 )0.5(74% )]TJ 0.263 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 72%, \026)Tj /Span<>> BDC ( )Tj EMC (\035\024\020\017\f\021\017\004\036\f\022\017\005 \022\024\220\235\235\017\ )Tj 0 Tw (-)Tj 0.169 Tw T* (\006\017\036\027\021 \(\210\231 1,20 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\t\005 1 \n\n \030\021. \f\021.\) \031\022\026\t\r\026\036\ \021 )Tj -0.024 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.182 0 Td [(\016\030\022\024 )0.5(\r\t\030\026\032\036\027\027\t\005 )0.6(\007\024\024\026\r\017\f\017\n\t\005 )0.6(\b\026\030\026\022\021\036\030 )0.5(\030\017\f\022\026.)]TJ 0.059 Tw -1.182 -1.218 Td (\230\027\021\036\020\030\026\035\034\027\026\016 \n\024\007\036\035\034,\ \r\022\035\033\004\026\033\013\026\016 \f\r\024\002\024\007\027\t\005 \024\ \022\f\017)Tj 0 Tw (-)Tj 0.087 Tw T* (\023\030\024\035\017\027, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC [(\204\212\202, \023\024\022\026\026\035\026 A)17(UC 0,90, \004\021\024 \f\024\023\024\f\021\026)]TJ 0 Tw (-)Tj 0.081 Tw T* (\r\017\n\024 \f)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\017\n\017 \022\024\n\002\017\027\017\030\024\r\026\027\027\ \t\n\017 \001\022\026\035\026\n\017, \023\030\036\007)Tj 0 Tw (-)Tj 0.13 Tw T* (\035\024\032\036\027\027\t\n\017 \007\035\016 \222\217\207, \215\025\221\ \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \024\006\036\027\024\004\027\t\b\ )Tj 0 Tw T* [(\f\017\f\021\036\n \(\027\026\023\030\017\n\036\030, Dutch leak)-16.8(a)-17(ge scor)-24(e \017)]TJ /Span<>> BDC ( )Tj EMC (\007\030.\) [10].)Tj 0.558 Tw T* (\222 \023\030\026\022\021\017\004\036\f\022\024\005 \021\024\004\022\017\ \030\036\027\017\016 \023\024\035\031\004\036\027\027\t\036 \007\026\027\ )Tj 0 Tw (-)Tj 0.516 Tw T* (\027\t\036 \235\024\030\n\017\030\031\033\021 \022\024\027\006\036\023\006\ \017\033 \030\026\027\027\036\005 \f\021\030\026\021\017\235\017\022\026\ )Tj 0 Tw (-)Tj 0.405 Tw T* (\006\017\017 \030\017\f\022\026. \215\026\006\017\036\027\021\024\r, \031\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \031\032\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 )Tj 0.695 Tw T* (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\ \t\016\r\035\016\033\021\f\016: \f\r\024\002\024\007\027\t\005 )Tj 0.316 Tw T* (\024\022\f\017\023\030\024\035\017\027)Tj /Span<>> BDC ( )Tj EMC 5.471 0 Td (>)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td (15)Tj /Span<>> BDC ( )Tj EMC 1.548 0 Td [(\n\022\n\024\035\034/\035, )0.5(\200\207\212)]TJ /Span<>> BDC ( )Tj EMC 6.915 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td [(15 )0.5(\n\n )0.5(\030\021. )0.5(\f\021. )]TJ 0.105 Tw -16.032 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\027\n\024\035\034/\n\035, \n\024\032\027\024 \024\021\027\036\f\021\017\ \022)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \r\t\f\024)Tj 0 Tw (-)Tj 0.208 Tw T* (\022\024\020\024 \030\017\f\022\026 \203\202 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\n\026\021\030\017\r\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017: \031\f\017)Tj 0 Tw (-)Tj 0.042 Tw T* (\035\036\027\027\024\020\024 \n\024\027\017\021\024\030\017\027\020\026,\ \002\024\035\036\036 \032\201\f\021\022\024\020\024 \022\024\027\021\030\ \024\035\016 \200\207\212, )Tj 0.208 Tw T* (\022\024\030\030\036\022\006\017\017 \024\022\f\017\007\026\021\017\r\027\ \024\020\024 \f\021\030\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\017\022\024\020\024 )Tj 0.146 Tw T* (\023\024\030\024\020\026 \007\035\016 \r\t\023\024\035\027\036\027\017\016\ \007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \030\036\035\026\ \023\026\030\024)Tj 0 Tw (-)Tj T* (\021\024\n\017\017 \017\035\017 \030\036\r\017\017\017 \026\027\026\f\021\ \024\n\024\026.)Tj 0.204 Tw T* (\210\004\036\r\017\007\027\024, \004\021\024 \023\030\036\007\035\024\032\ \036\027\027\026\016 \n\024\007\036\035\034 \021\030\036\002\031\036\021\ \r\026\035\017)Tj 0 Tw (-)Tj 0.281 Tw T* (\007\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\r\017\f\017\n\t\b \r\t\002\024\030\022\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\035\036\027\017\016 )Tj 0.67 Tw 23.244 64.543 Td (\f)Tj /Span<>> BDC ( )Tj EMC 1.339 0 Td [(\f\031\013\036\f\021\r\031\033\013\017\n\017 )0.6(\026\035\020\024\030\017\021\n\026\n\017, )0.6(\002\026\017\030\031\033\013\017\n\017\f\016 )]TJ 0.124 Tw -1.339 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\222\217\207, \215\025\221 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\030\026\007\017\024\035\024\020\017\004\036\ \f\022\017\b \022\030\017\021\036\030\017\016\b. )Tj 0.199 Tw T* [(\210\007\027\026\022\024 \f\024\023\024\f\021\026\r\017\n\024\f\021\034 \ \027\026\001\017\b \031\f\035\024\r\027\t\b A)17(UC \017)]TJ /Span<>> BDC ( )Tj EMC (\210\231 )Tj 0.034 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n\017 \f\024\r\030\036\n\036\027\027\t\b \017\f\f\035\ \036\007\024\r\026\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\n\026\030\022\036)Tj 0 Tw (-)Tj 0.109 Tw T* (\030\026\n \203\202 \f\r\017\007\036\021\036\035\034\f\021\r\031\036\021\ \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \r\022\035\033\004\036\027\017\036 \023\024\022\ \026)Tj 0 Tw (-)Tj -0.001 Tw T* (\026\021\036\035\036\005 \024\022\f\017\007\026\021\017\r\027\024\020\024\ \f\021\030\036\f\f\026, \022\024\035\035\026\020\036\027\024\035\017\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\200\207\212 )Tj -0.032 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\t\036 \001\022\026\035\t \ \017\n\036\036\021 \030\036\026\035\034\027\t\036 \023\036\030\f\023\036\ \022\021\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\t [13].)Tj 0.048 Tw T* (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \001\r\024\ \r \021\024\035\f\021\024\022\017\001\036\004\027\024\020\024 \026\027\026\ \f\021\024\n\024)Tj 0 Tw (-)Tj 0.039 Tw T* (\026 \024\f\021\026\201\021\f\016 \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \021\016\032\201\035\t\b \024\f\035\024\ \032\027\036\027\017\005 )Tj -0.038 Tw T* (\030\036\036\022\006\017\024\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\t\b \024\023\036\030\ \026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj -0.016 Tw T* (\f\021\024\005 \022\017\001\022\036; \036\201 \030\026\r\017\021\017\036\ \024\002\031\f\035\024\r\035\036\027\024 \f\024\004\036\021\026\027\017\ \036\n \027\026)Tj 0 Tw (-)Tj 0.228 Tw 0 -1.218 TD (\030\031\001\036\027\017\005 \n\017\022\030\024\006\017\030\022\031\035\016\ \006\017\017, \024\022\f\017\007\026\021\017\r\027\024\020\024 \f\021\030\ \036\f\f\026, )Tj 0.116 Tw 0 -1.218 TD (\007\036\020\030\026\007\026\006\017\017 \022\024\035\035\026\020\036\027\ \024\r\024\020\024 \n\026\021\030\017\022\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\024\005 \020\017\023\036\030\021\036\027\017\017.)Tj 0.034 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \031\032\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 )Tj 0.032 Tw T* (\023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\t\016\r\035\016\033\ \021\f\016 \r\t\030\026\032\036\027\027\t\036 \017\n\036\027\036\027\017\ \016 )Tj 0.165 Tw T* (\023\030\024- \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\024\022\f\017\007\026\027\021\027\024\020\024 \002\026\035\ \026\027\f\026 \(\023\024\r\t\001\036\027\017\036 \204\212\202 )Tj 0.414 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\036\027\024\r\t\b \022\024\027\255\033\020\026\021\024\r, \f\027\ \017\032\036\027\017\036 \026\f\022\024\030\002\017\027\024\r\024\005 )Tj -0.006 Tw T* (\022\017\f\035\024\021\t\), \023\024\022\026\026\021\036\035\017 \021\022\ \026\027\036\r\024\005 \020\017\023\024\022\f\017\017 \(\030\024\f\021 \035\ \026\022\021\026)Tj 0 Tw (-)Tj -0.012 Tw T* [(\021\026\), \031\f\017\035\036\027\017\036 \022\024\035\035\026\020\036\027\ \024\035\017\026 )0.5(\(\023\024\r\t\001\036\027\017\036 )0.5(\f\r\024\002\024\007\027\024\020\024 )]TJ 0.249 Tw T* (\024\022\f\017\023\030\024\035\017\027\026\), \f\027\017\032\036\027\017\ \036 \022\024\027\006\036\027\021\030\026\006\017\017 \f\036\030\024\021\ \024\027\017\027\026 )Tj 0.019 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.769 0 Td [(\027\026\004\017\n\024\036 )0.5(\031\r\036\035\017\004\036\027\017\036 )0.5(\200\207\212 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.443 0 Td [(\f\030\026\r\027\036\027\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t)Tj 0 Tw (-)Tj 0.171 Tw -13.212 -1.218 Td (\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\002\035\026\020\024\023\030\017\016\021\027\t\n \021\036\004\036\027\017\ \036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\ \024 )Tj 0 Tw T* (\023\036\030\017\024\007\026.)Tj 0.114 Tw T* [(\025\024\n\002\017\027\017\030\024\r\026\027\027\026\016 )0.6(\023\030\024\020\027\024\f\021\017\004\036\f\022\026\016 )0.6(\n\024\007\036\035\034, )0.5(\r\022\035\033\004\026)]TJ 0 Tw (-)Tj 0.132 Tw T* (\033\013\026\016 \f\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\ \035\017\027, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202, \024\002\035\026\007\026\036\021 )Tj 0.289 Tw T* [(\r\t\f\024\022\024\005 )0.5(\007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 )0.6(\006\036\027\027\024\f\021\034\033 )0.6(\(A)17(UC)]TJ /Span<>> BDC ( )Tj EMC 19.034 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 1.021 0 Td (0,90\) )Tj 0.173 Tw -20.055 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 \024\022\024\ \035\024 85% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 )Tj 0.214 Tw T* (\023\024\030\016\007\022\026 80% \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\017\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\017)Tj 0 Tw (-)Tj 0.542 Tw T* [(\n\017 )0.5(\024\023\031\002\035\017\022\024\r\026\027\027\t\n\017 )0.5(\026\035\020\024\030\017\021\n\026\n\017, )0.5(\024\f\027\024\r\026\027\027\t\n\017 )]TJ 0.03 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \222\217\207, \023\030\024\022\026\ \035\034\006\017\021\024\027\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b )Tj 0 Tw T* (\001\022\026\035\026\b.)Tj 0.086 Tw T* (\212\035\016 \024\022\024\027\004\026\021\036\035\034\027\024\005 \024\006\ \036\027\022\017 \022\035\017\027\017\004\036\f\022\024\005 \027\026\004\ \017\n\024\f\021\017 )Tj 0.532 Tw T* (\023\030\036\007\035\024\032\036\027\027\t\b \023\030\024\020\027\024\f\021\ \017\004\036\f\022\017\b \017\027\007\017\022\026\021\024\030\024\r \027\ \036)Tj 0 Tw (-)Tj 0.185 Tw T* [(\024\002\b\024\007\017\n\t \023\030\024\f\023\036\022\021\017\r\027\t\036\ )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 \f)]TJ /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n )Tj 0.232 Tw T* (\002\024\035\034\001\017\b \027\036\026\r\017\f\017\n\t\b \022\024\020\024\ \030\021 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\t\n )Tj -0.033 Tw T* (\f\030\026\r\027\036\027\017\036\n \f)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\031\033\013\017\n\017 \002\017\024\n\026\030\022\036\ \030\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017)Tj 0 Tw (-)Tj T* (\027\017\022\024-\030\026\007\017\024\035\024\020\017\004\036\f\022\017\n\ \017 \n\024\007\036\035\016\n\017.)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\017\027\022\032\025\034\030\036\025\034\223 \034\255\255\035\036\031\017\ \026\032\025\034\223)Tj /T1_0 1 Tf -0.007 Tw 0 -1.218 TD (\203\026\f\021\024\016\013\036\036 \017\f\f\035\036\007\024\r\026\027\017\ \036 \r\t\023\024\035\027\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r)Tj 0 Tw (-)Tj 0.208 Tw T* (\027\024\n \007\017\026\005\027\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \253\f\035\031\004\026\005\226\022\024\027\021\030\024\035\ \034\273 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017)Tj 0 Tw (-)Tj 0.205 Tw T* [(\030\024\r\026\027\017\036\n )0.5(\f\024\023\024\f\021\026\r\017\n\024\005 )0.6(\020\030\031\023\023\t )0.5(\023\026\006\017\036\027\021\024\r )0.6(\002\036 )0.5(\203\202. )]TJ 0.092 Tw T* (\221\026\022\024\005 \023\024\007\b\024\007 \023\024\r\024\035\016\036\021\ \035\031\004\001\036 \022\024\027\021\030\024\035\017\030\024\r\026\021\ \034 \r\035\017)Tj 0 Tw (-)Tj 0.259 Tw T* [(\016\027\017\036 \002\026\024\r\t\b \022\024\027\235\026\031\027\007\036\ \030\024\r, )0.5(\024\007\027\026\022\024 \024\020\030\026\027\017\004\017\r\026\036\021 \ )]TJ 0.156 Tw T* (\024\002\024\002\013\026\036\n\024\f\021\034 \023\024\035\031\004\036\027\ \027\024\005 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \n\ \024\007\036\035\017 )Tj 0.252 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\033 \023\024\023\031\035\016\006\017\033 \002\024\035\034\027\t\b, \ \023\036\030\036\027\201\f\001\017\b \030\036\036\022\006\017\017 )Tj 0.209 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. \212\024\023\024\035\027\ \017\021\036\035\034\027\t\n \024\020\030\026\027\017\004\036\027\017\036\ \n \016\r)Tj 0 Tw (-)Tj -0.009 Tw T* (\035\016\036\021\f\016 \024\021\027\024\f\017\021\036\035\034\027\024 \027\ \036\002\024\035\034\001\024\005 \024\002\255\201\n \r\t\002\024\030\022\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.102 Tw T* (\f\031\021\f\021\r\017\036 \r\027\036\001\027\036\005 \(\n\036\032\006\036\ \027\021\030\024\r\024\005\) \r\026\035\017\007\026\006\017\017 \n\024\007\ \036)Tj 0 Tw (-)Tj 0.105 Tw T* [(\035\017. \212\035\016 \024\022\024\027\004\026\021\036\035\034\027\024\020\ \024 \023\024\007\021\r\036\030\032\007\036\027\017\016 )0.5(\023\024\035\031\004\036\027\027\t\b )]TJ 0.126 Tw T* (\030\036\031\035\034\021\026\021\024\r \027\036\024\002\b\024\007\017\n\ \t \023\030\024\f\023\036\022\021\017\r\027\t\036 \017\f\f\035\036\007\024\ \r\026)Tj 0 Tw (-)Tj T* (\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\r\017\f\017\n\t\b \022\024\020\024\030\021\027\t\b \r\t\002\ \024\030\022\026\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 28.14 56.0378 Tm (98)Tj ET endstream endobj 993 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.391 Tw 10 0 0 10 42.5197 724.8299 Tm [(\024\022\f\017\023\030\024\035\017\027 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035 )0.6(\b\024\030\024\001\031\033 )0.5(\007\017\f\022\030\017)]TJ 0 Tw (-)Tj 0.143 Tw 0 -1.218 TD [(\n\017\027\017\030\031\033\013\031\033 )0.5(\f\023\024\f\024\002\027\024\f\021\034: )0.5(A)17(UC )0.5(0,83 \(95% )0.5(\212\230 0,72\226)]TJ 0 Tw T* (0,93; )Tj /T1_2 1 Tf 2.321 0 Td (p)Tj /T1_1 1 Tf 0.092 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). \215\024\030\024\020\024\r\024\036 \027\026\004\036\027\017\036\ )Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC (\n\022\n\024\035\034/\035 )Tj 0.193 Tw -2.321 -1.218 Td (\024\002\036\f\023\036\004\017\r\026\035\024 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\034 79,1% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004)Tj 0 Tw (-)Tj 0.24 Tw T* (\027\024\f\021\034 77,3%, \f)Tj /Span<>> BDC ( )Tj EMC (\215\215\037 87,2% \017)Tj /Span<>> BDC ( )Tj EMC (\210\215\037 65,4%. \212\035\016 \200\207\212 )Tj 0.276 Tw T* (\023\024\030\024\020)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC [(\n\n \030\021. \f\021. \b\026\030\026\022\021\036\030\017\024\r\026\035\ \f\016 A)17(UC 0,78 )]TJ 0.251 Tw 0 -1.218 TD (\(95% \212\230 0,65\2260,90; )Tj /T1_2 1 Tf 0 Tw 9.039 0 Td (p)Tj /T1_1 1 Tf 0.251 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC 1.945 0 Td (0,001\), \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 )Tj 0.371 Tw -10.984 -1.218 Td (69,8% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 72,7%. \212\035\016\ \204\212\202 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\030\024\020\024\n)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC [(4,0 \027\n\024\035\034/\n\035 A)17(UC \f\024\f\021\026\r\017\035\026 0,80 \(95% \212\230 )]TJ 0 Tw T* (0,68\2260,91; )Tj /T1_2 1 Tf 4.787 0 Td (p)Tj /T1_1 1 Tf 0.317 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 74,4%, )Tj 0 Tw -4.787 -1.218 Td (\f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 77,3%.)Tj 0.059 Tw T* (\230\027\021\036\020\030\026\035\034\027\026\016 \n\024\007\036\035\034,\ \r\022\035\033\004\026\033\013\026\016 \f\r\024\002\024\007\027\t\005 \024\ \022\f\017)Tj 0 Tw (-)Tj -0.007 Tw 0 -1.218 TD (\023\030\024\035\017\027, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202, \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \035\026 \027\026\017\r\t\f\001\031\033 )Tj 0.125 Tw 0 -1.218 TD [(\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \021\024\004\027\ \024\f\021\034: A)17(UC 0,93 \(95% \212\230 0,84\226)]TJ 0 Tw 0 -1.218 TD (0,98; )Tj /T1_2 1 Tf 2.442 0 Td (p)Tj /T1_1 1 Tf 0.213 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \023\030\036\r\024\f\b\024\007\016 \022\026\032\007\t\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\t\b )Tj 0 Tw -2.442 -1.218 Td (\n\026\030\022\036\030\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\013\026\007\017 \023\024\007 )Tj /T1_2 1 Tf -0.019 Tc 0.019 Tw [(RO)-18.9(C)]TJ /T1_1 1 Tf 0 Tc 0 Tw 12.467 0 Td (-\022\030\017\r\024\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.01 Tc 0.435 Tw -12.467 -1.218 Td (\221\026\022\017\n \024\002\030\026\024\n, \023\024\022\026\026\021\036\ \035\017, \024\021\030\026\032\026\033\013\017\036 \017\027\021\036\027)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.252 Tw T* [(\f\017\r\027\024\f\021\034 )0.5(\022\024\035\035\026\020\036\027\024\035\017\026 )0.5(\(\f\r\024\002\024\007\027\t\005 )0.5(\024\022\f\017\023\030\024\035\017\027\),)10( )]TJ 0.232 Tw T* [(\r\t\030\026\032\036\027\027\024\f\021\034 )0.5(\r\027\031\021\030\017\002\030\033\001\027\024\005 )0.5(\020\017\023\036\030\021\036\027\017\017 )0.5(\(\200\207\212\))10( )]TJ 0.165 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.935 0 Td [(\031\030\024\r\036\027\034 )0.5(\023\036\030\036\022\017\f\027\024\020\024 )0.5(\024\022\017\f\035\036\027\017\016 )0.5(\035\017\023\017\007\024\r )0.5(\(\204\212\202\),)10( )]TJ 0.352 Tw -0.935 -1.218 Td [(\024\002\035\026\007\026\033\021 )0.5(\r\t\f\024\022\024\005 )0.5(\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 )0.5(\027\026\004\017\n\024\f\021\034\033)10( )]TJ 0.373 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \030\017\f\022\026 \027\036\f\024\f\ \021\024\016\021\036\035\034\027\024\f\021\017 \021\024\035\f\021\024\022\ \017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.345 Tw T* (\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\020\031\021 \002\t\021\034 \017\f\023\024\035\034\024\r\026\027\t\ )10( )]TJ 0.031 Tw T* [(\007\035\016 )0.5(\030\026\027\027\036\005 )0.5(\007\017\235\235\036\030\036\027\006\017\026\006\017\017 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 18.769 0 Td [(\f\021\036\023\036\027\017)10( )]TJ -0.01 Tw -18.769 -1.218 Td (\030\017\f\022\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 14 0 0 14 275.0305 724.8299 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.045 Tw 10 0 0 10 274.9606 700.4739 Tm [(\215\024\035\031\004\036\027\027\t\036 )0.6(\007\026\027\027\t\036 )0.5(\023\024\007\021\r\036\030\032\007\026\033\021 )0.6(\n\031\035\034\021\017\235\026\022\021\024\030\027\031\033 )]TJ 0.145 Tw T* (\023\030\017\030\024\007\031 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \026\027\026\f\021\024\n\024\026, \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\021\024 \031\022\026)Tj 0 Tw (-)Tj T* (\t\r\026\033\021 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\036 \024\002\024\030\t [9].)Tj 0.117 Tw T* (\217\016\007 \n\036\021\026\026\027\026\035\017\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\017\b \024\002\024\030\024\ \r \023\024\022\026)Tj 0 Tw (-)Tj -0.042 Tw T* (\026\035, \004\021\024 \007\017\027\026\n\017\022\026 CRP \017)Tj /Span<>> BDC ( )Tj EMC (\215\025\221 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\036 3\2265)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\024\022 \023\024\f\035\036 )Tj -0.007 Tw 0 -1.218 TD [(\022\024\035\024\030\036\022\021\026\035\034\027\t\b \030\036\036\022\006\ \017\005 \024\002\036\f\023\036\004\017\r\026\036\021 A)17(UC \023\024\030\016\007\022\026 )]TJ 0.172 Tw 0 -1.218 TD [(0,80\2260,90, \023\024\r\024\035\016\016 \007\024\f\021\026\021\024\004\ \027\024 )0.5(\027\026\007\201\032\027\024 \017\f\022\035\033\004\026\021\034 )]TJ 0.205 Tw T* (\203\202 \023\030\017)Tj /Span<>> BDC ( )Tj EMC 3.561 0 Td [(\027\017\022\017\b \027\026\004\036\027\017\016\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\024\036\r\030\036\n\036\027\027\024 )0.5(\026\023\024\007\024)]TJ 0 Tw (-)Tj 0.201 Tw -3.561 -1.218 Td (\030\017\021\034 \024\f\035\024\032\027\036\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \027\026\030\026\f\021\026\027\017\017 [10]. \221\036\n \027\036 \ )Tj 0.038 Tw T* (\n\036\027\036\036, \220\021\017 \n\026\030\022\201\030\t \024\021\030\026\ \032\026\033\021, \023\030\036\032\007\036 \r\f\036\020\024, \f\017\f\021\ \036\n)Tj 0 Tw (-)Tj 0.058 Tw 0 -1.218 TD [(\027\024\036 )0.5(\r\024\f\023\026\035\036\027\017\036, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.821 0 Td [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 )0.6(\035\024\022\026\035\034\027\t\036 )0.5(\023\030\024\006\036\f\f\t )]TJ -0.001 Tw -7.821 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(\024\027\036 )0.5(\026\027\026\f\021\024\n\024\026 )0.5(\(\024\022\f\017\007\026\021\017\r\027\t\005 )0.5(\f\021\030\036\f\f, )0.6(\007\036\020\030\026\007\026\006\017\016 )]TJ 0.297 Tw -0.705 -1.218 Td (\022\024\035\035\026\020\036\027\026, \027\026\030\031\001\036\027\017\016\ \n\017\022\030\024\006\017\030\022\031\035\016\006\017\017\) \024\f\021\ \026\033\021\f\016 )Tj -0.031 Tw 0 -1.218 TD (\n\036\027\036\036 \017\f\f\035\036\007\024\r\026\027\027\t\n\017. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \001\017\030\024\022\024 \017\f\023\ \024\035\034)Tj 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\031\036\n\t\b \r\024\f\023\026\035\017\021\036\035\034\027\t\b \n\026\030\ \022\036\030\024\r \(\222\217\207\), \017\031\004\036\027\027\t\036 )Tj 0.156 Tw 0 -1.218 TD (\027\026\n\017 \023\024\022\026\026\021\036\035\017 \024\021\030\026\032\ \026\033\021 \f\023\036\006\017\235\017\004\036\f\022\017\036 \023\026\021\ \024\235\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\017\024\035\024\020\017\004\036\f\022\017\036 \r\036\027\034\016.)Tj 0.725 Tw 0 -1.218 TD (\210\f\024\002\036\027\027\024\f\021\034\033 \023\030\036\007\f\021\026\r\ \035\036\027\027\024\005 \030\026\002\024\021\t \016\r\035\016\036\021\f\ \016 )Tj 0.495 Tw T* (\026\022\006\036\027\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b, \024\021\030\026\032\026\033\013\ \017\b \f\021\030\031\022\021\031\030\027\024-)Tj 0.381 Tw 0 -1.218 TD (\235\031\027\022\006\017\024\027\026\035\034\027\024\036 \f\024\f\021\024\ \016\027\017\036 \f\024\036\007\017\027\017\021\036\035\034\027\024\005 \ \021\022\026\027\017 )Tj 0.118 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\r\024\020\024 \022\026\030\022\026\f\ \026 \f\021\036\027\022\017 \022\017\001\022\017. \215\024\r\t\001\036\027\ \017\036 )Tj 0.21 Tw 0 -1.218 TD (\031\030\024\r\027\016 \f\r\024\002\024\007\027\024\020\024 \024\022\f\017\ \023\030\024\035\017\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 )Tj 0.772 Tw T* (\f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \024\002 \026\022\021\ \017\r\017\026\006\017\017 \022\024\035\035\026\020\036\027\024\035\017\ \026 )Tj ET q /GS0 gs 453.543294 0 0 262.0472365 42.5196991 144.2708787 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.095 Tw 9 0 0 9 42.5197 133.3701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( ROC-\n\032\022\021\013\027 \024\021\031\240\031\030\025\031\b\031 \031\n\ \024\022\033\032\031\f\022\025\020, \021\025\r\023\032\022\240\032\005\213\ \025\031\b\031 \030\020\021\f\027\025\022\t, \026\020\f\031\025\031\021\031\ \b\031 \030\022\020\f\017\030\027\b\022\030\020 \022)Tj /Span<>> BDC ( )Tj EMC (\022\025\023\027\b\032\020\f\017\025\031\235 )Tj 0.085 Tw 0 -1.2 TD [(\026\031\030\027\f\022 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 4.071 0 Td [(\033\032\031\b\025\031\016\022\032\031\021\020\025\022\022 )0.6(\025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\022 )0.6(\023\031\f\024\023\031\n\022\213\027\007\025\031\b\031 )0.6(\020\025\020\024\023\031\026\031\016\020. )0.6(\205\021\031\240\031\030\025\013\235 \031\n\024\022\033\032\031\f\022\025\ : AUC 0,83; )0.5(\211\221\220: )]TJ 0 Tw -4.071 -1.2 Td (AUC 0,78; \215\220\003: AUC 0,80; \022\025\023\027\b\032\020\f\017\025\020\ \t \026\031\030\027\f\017: AUC 0,93)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.037 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)19(OC cur)-42(v)13(es for free h)12(y)14(dro)14(xyp)46(roline, intra-abdominal p)46(ressure, malondialdeh)12(y)14(de, and the)]TJ /Span<>> BDC ( )Tj EMC [(integ)14(rated model in p)46(redicting )]TJ 0.091 Tw T* [(colonic anastomo)13.1(tic leak)11.1(ag)12(e. 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DmHi0J(UTDΨ^UX\?xc3ތ ;p5UEtӚ**y0Ha7Na;zdg*gKz[ˁ0Z/#^08тƦ)&f'#?  :08:pTo>ypX48ӍT33USf@>oN+<%X6ov&8`hi2LK碝a"x bѲapq5ͣ5/% mz=jk MTM32LiFxkW{ѽчa;14SŊg46 >/5313UU`-3m%:ђo3F]3yN֧ɓ6Gේ<Wql 8H*+&rDⷫzpۇFqjꮩ֪@`&Nv7yŢ"cDDFxco>z4ՁMULr33េUTW]SUa(iH圑iѽFNN U\a33M7Yc{[ ᷼T׀o6 y눣crZ[7V`0{́|.[~0<|j'b")]@0{ 4o.4t^5ULSD˦nNoVyia92D=[ɇ޽}bj)ͼ<Ɇo M F-8}׃TUH> xioNyp͢hΈ_*w0̈́z' N(/fx|457]5awl>&&"8NU1/O6kaX<5Sa"UV4dL.Npq(,DQU89^C *w >mcx8 "ic8H^K>6)ޝ-hW|>cxHUc \M3N\ӜHa$F L")"5dm7#yVW5b&qfEYX}`w᳼8*>ovz0115Uy`uSMW3Ž4N N,4apxZiM4U3LETL[USDa&i'2_5xl<)F W45QT^&"כX}INx^(ެ{ -ŧ ]X>R-Mފ7co Myqq_YsDLD$CFa]hӵ1گ j\5;,ڋૌi&^C実 xkov\-QUX<TlfѲF4D艗xi/c.-Xk.55WS1V\`x+SUu&)\DDg0US4UhUj6x|aɍl>>stream endstream endobj 992 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.029 Tw 10 0 0 10 70.8661 444.7359 Tm (\030\021. \f\021.; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.029 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\024\030\026\f\021\027\t\n \b\026\030\026\022\021\036\ \030\017\f\021\017)Tj 0 Tw (-)Tj -0.029 Tw 0 -1.218 TD (\022\026\n \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\n \023\024\ \022\026\026\021\036\035\016\n \027\036 \002\t\035\024 \031\f\021\026)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\024\r\035\036\027\024 \027\026\035\017\004\017\036 \f\021\026\021\017\ \f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\ \017\005 )Tj 0 Tw T* (\n\036\032\007\031 \020\030\031\023\023\026\n\017.)Tj 0.383 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \031\030\024\r\036\027\034 \f\ \r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026 )Tj 0.028 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \002\t\035 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \r\t\001\036\ , )Tj 0.011 Tw T* (\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \(18,0 [15,7\226\ 19,6] \023\030\024\021\017\r 12,7 )Tj 0.082 Tw T* ([11,1\22614,8] \n\022\n\024\035\034/\035; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.082 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \004\021\024 \f\r\017\007\036\021\036\035\034\f\021\r\031)Tj 0 Tw (-)Tj 0.176 Tw T* (\036\021 \024\002 \026\022\021\017\r\027\024\n \030\026\030\031\001\036\ \027\017\017 \022\024\035\035\026\020\036\027\024\r\024\020\024 \n\026\021\ \030\017\022)Tj 0 Tw (-)Tj 0.135 Tw T* (\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026\f\021\024\n\024\026. \215\024\022\026\026\021\ \036\035\017 \200\207\212 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \203\202 )Tj 0.328 Tw T* (\f\024\024\021\r\036\021\f\021\r\024\r\026\035\017 \r\027\031\021\030\017\ \002\030\033\001\027\024\005 \020\017\023\036\030\021\036\027\017\017 I\ \226II )Tj 0.085 Tw T* (\f\021\036\023\036\027\017, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \024\ \f\021\026\r\026\035\017\f\034 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \007\024\023\031\f\021\017\n\t\b \027\026\ \004\036\027\017\005.)Tj 0.131 Tw T* [(\212\035\016 \023\024\f\021\030\024\036\027\017\016 \n\027\024\020\024\235\ \026\022\021\024\030\027\024\005 )0.5(\035\024\020\017\f\021\017\004\036\f\022\024\005 \030\036)]TJ 0 Tw (-)Tj 0.283 Tw T* (\020\030\036\f\f\017\024\027\027\024\005 \n\024\007\036\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\005 \023\031\035 \023\030\036\007\017\022\021\024\ \030\024\r )Tj 0.419 Tw T* [(\r\022\035\033\004\026\035\017 )0.6(\023\024\022\026\026\021\036\035\017, )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\r\001\017\036\ )0.6(\023\024)]TJ 0 Tw (-)Tj 0.169 Tw T* [(\021\036\027\006\017\026\035\034\027\031\033 )0.6(\026\f\f\024\006\017\026\006\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 12.061 0 Td [(\203\202 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.489 0 Td (\024\007\027\024\235\026\022\021\024\030\027\024\n )Tj 0.018 Tw -15.55 -1.218 Td (\026\027\026\035\017\036 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.018 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,10\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033\013\017\036 \023\026\021\024\020\036\027\036\021\017\004\036\ \f\022\024\036 \024\002\024)Tj 0 Tw (-)Tj 0.169 Tw T* (\f\027\024\r\026\027\017\036 \(\022\035\017\027\017\022\024-\007\036\n\024\ \020\030\026\235\017\004\036\f\022\017\036 \b\026\030\026\022\021\036\030\ \017\f\021\017)Tj 0 Tw (-)Tj 0.03 Tw T* [(\022\017, \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\ \036 )0.5(\023\026\030\026\n\036\021\030\t, \n\026\030\022\036\030\t \024\022\f\017\ \007\026)]TJ 0 Tw (-)Tj 0.029 Tw T* (\021\017\r\027\024\020\024 \f\021\030\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\035\017\026, \200\207\212\). \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 )Tj 0.332 Tw T* (\023\024\001\026\020\024\r\024\020\024 \r\022\035\033\004\036\027\017\016\ \023\030\036\007\017\022\021\024\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\235\017\027\026\035\034\027\031\033 )Tj 0.289 Tw T* (\n\024\007\036\035\034 \r\024\001\035\017 \021\030\017 \027\036\026\r\017\ \f\017\n\t\b \235\026\022\021\024\030\026: \031\030\024\r\036\027\034 )Tj 0.063 Tw T* (\f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026, \204\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (\200\207\212 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 )Tj 0 Tw T* (\023\024\f\035\036 \024\023\036\030\026\006\017\017.)Tj 0.21 Tw T* (\200 \024\022\024\027\004\026\021\036\035\034\027\024\005 \n\024\007\036\ \035\017 \023\024\r\t\001\036\027\017\036 \022\024\027\006\036\027\021\030\ \026\006\017\017 )Tj 0.124 Tw T* (\f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026 \027\026)Tj /Span<>> BDC ( )Tj EMC (1 \n\022\n\024\035\034/\035 \026\f\f\024\006\017\017\030\024)Tj 0 Tw (-)Tj 0.172 Tw T* [(\r\026\035\024\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\031\r\036\035\017\004\036\027\017\036\n )0.5(\030\017\f\022\026 )0.5(\203\202 )0.5(\(\210\231 1,35; )0.5(95% \212\230 )]TJ 0 Tw T* (1,08\2261,69; )Tj /T1_1 1 Tf 4.527 0 Td (p)Tj /T1_0 1 Tf 0.057 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,009\). \212\035\016 \200\207\212 \022\026\032\007\t\036 \007\024\023\024\ \035\027\017\021\036\035\034)Tj 0 Tw (-)Tj 0.069 Tw -4.527 -1.218 Td (\027\t\036 1 \n\n \030\021. \f\021. \023\030\017\r\024\007\017\035\017 \022\ )Tj /Span<>> BDC ( )Tj EMC (\030\024\f\021\031 \001\026\027\f\024\r \027\036\f\024\f\021\024)Tj 0 Tw (-)Tj 0.077 Tw T* (\016\021\036\035\034\027\024\f\021\017 \026\027\026\f\021\024\n\024\026\ \(\210\231 1,35; 95% \212\230 1,10\2261,65; )Tj /T1_1 1 Tf 0 Tw 23.244 36.534 Td (p)Tj /T1_0 1 Tf 0.172 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\). \211\r\036\035\017\004\036\027\017\036 \031\030\024\r\027\016 \204\ \212\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\027\n\024\035\034/\n\035 )Tj 0.179 Tw T* (\021\026\022\032\036 \016\r\035\016\035\024\f\034 \027\036\026\r\017\f\017\ \n\t\n \023\030\036\007\017\022\021\024\030\024\n \203\202 \(\210\231 )Tj 0 Tw T* (2,86; 95% \212\230 1,25\2266,56; )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013\) \(\221\026\002\035. 2\).)Tj 0.277 Tw T* [(\200\022\035\033\004\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.083 0 Td [(\n\024\007\036\035\034 )0.5(\r\024\030\026\f\021\026, )0.5(\023\024\035\026, )0.5(\007\035\017\021\036\035\034\027\024\f\021\017 )]TJ 0.017 Tw -6.083 -1.218 Td (\024\023\036\030\026\006\017\017, \024\002\255\201\n\026 \022\030\024\r\024\ \023\024\021\036\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \022\035\017\027\017\022\024-\007\036)Tj 0 Tw (-)Tj T* (\n\024\020\030\026\235\017\004\036\f\022\017\b \023\026\030\026\n\036\021\ \030\024\r \027\036 \023\030\017\r\024\007\017\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\n\024)Tj (-)Tj T* (\n\031 \031\035\031\004\001\036\027\017\033 \022\026\004\036\f\021\r\026\ \n\024\007\036\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \f\024\023\030\024\r\024\032\007\026\035\024\f\034 )Tj 0.026 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\t\n )0.5(\r\022\035\026\007\024\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\017\f\022 )0.5(\203\202 )0.5(\()]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.026 Tw /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC 20.425 0 Td (0,05 )Tj 0.174 Tw -20.425 -1.218 Td (\007\035\016 \f\024\024\021\r\036\021\f\021\r\031\033\013\017\b \022\024\ \220\235\235\017\006\017\036\027\021\024\r\), \023\024\220\021\024\n\031\ \220\021\017 )Tj 0.321 Tw T* (\023\036\030\036\n\036\027\027\t\036 \002\t\035\017 \017\f\022\035\033\004\ \036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\026\b \001\026\020\024\r\024\020\024 )Tj 0 Tw T* (\024\021\002\024\030\026.)Tj 0.3 Tw T* (\025\026\004\036\f\021\r\024 \017\021\024\020\024\r\024\005 \n\024\007\036\ \035\017 \002\t\035\024 \031\007\024\r\035\036\021\r\024\030\017\021\036\ \035\034)Tj 0 Tw (-)Tj -0.089 Tw T* [(\027\t\n: A)17(UC 0,93 \(95% \212\230 0,84\2260,98; )]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.089 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\); \023\f\036\r\007\024-R\262 )Tj 0.072 Tw T* (\203\026\005\007\032\036\035\022\036\030\022\026 0,65; \021\036\f\021 \216\ \024\f\n\036\030\026\226\214\036\n\036\001\024\031 \245\262)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9,0; )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf 0.014 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34, \004\021\024 \f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \ \024)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\036\n \f\024\020\035\026\f\017\017 \027\026)Tj 0 Tw (-)Tj T* (\002\035\033\007\026\036\n\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\022\026\026\027\027\t\b \r\036\030\024\016\021\027\024\ \f\021\036\005.)Tj 0.119 Tw T* (\212\035\016 \024\006\036\027\022\017 \023\030\024\020\027\024\f\021\017\ \004\036\f\022\024\005 \027\026\004\017\n\024\f\021\017 \024\021\007\036\ \035\034\027\t\b )Tj 0 Tw T* (\n\026\030\022\036\030\024\r \002\t\035 \023\030\024\r\036\007\201\027 )Tj /T1_1 1 Tf -0.019 Tc 0.019 Tw [(RO)-19(C)]TJ /T1_0 1 Tf 0 Tc 0 Tw 11.622 0 Td (-\026\027\026\035\017.)Tj -11.622 -1.218 Td (\215\030\017 )Tj /T1_1 1 Tf -0.019 Tc 0.019 Tw 2.233 0 Td [(RO)-19(C)]TJ /T1_0 1 Tf 0 Tc 0.379 Tw 1.469 0 Td (-\026\027\026\035\017\036 \031\030\024\r\036\027\034 \f\r\024\002\024\007\ \027\024\020\024 \024\022\f\017\023\030\024\035\017)Tj 0 Tw (-)Tj 0.158 Tw -3.702 -1.218 Td (\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC 2.729 0 Td [(2\2263-\017 \f\031\021\022\017 \023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 \007\036\n\024\027\f\021\030\017\030\024\ \r\026\035 )]TJ 0.277 Tw -2.729 -1.218 Td (\b\024\030\024\001\031\033 \007\017\f\022\030\017\n\017\027\017\030\031\033\ \013\031\033 \f\023\024\f\024\002\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024)Tj 0 Tw (-)Tj 0.13 Tw T* [(\001\036\027\017\017 \203\202: A)17.1(UC 0,83 \(95% \212\230 0,72\2260,93; )]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.13 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj 0.259 Tw T* (\210\023\021\017\n\026\035\034\027\024\036 \023\024\030\024\020\024\r\024\ \036 \027\026\004\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (15,0 \n\022\n\024\035\034/\035 )Tj 0.193 Tw T* (\024\002\036\f\023\036\004\017\r\026\035\024 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\034 79,1% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004)Tj 0 Tw (-)Tj 0.181 Tw T* (\027\024\f\021\034 77,3%, \023\024\035\024\032\017\021\036\035\034\027\031\ \033 \023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\ )Tj 0 Tw (-)Tj 0.279 Tw T* (\027\024\f\021\034 \(\215\215\037\) 87,2% \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\017\006\026\021\036\035\034\027\031\033 \023\030\024\020\027\ \024\f\021\017\004\036)Tj 0 Tw (-)Tj 0.157 Tw T* (\f\022\031\033 \006\036\027\027\024\f\021\034 \(\210\215\037\) 65,4%, \024\ \002\013\031\033 \021\024\004\027\024\f\021\034 78,5% )Tj 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.315 Tw T* [(\212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\f\r\024\002\024\007\027\024\020\024 )0.6(\024\022\f\017)]TJ 0 Tw (-)Tj 0.217 Tw T* (\023\030\024\035\017\027\026, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\017 \203\202 \023\030\ \036\007)Tj 0 Tw (-)Tj 0.259 Tw T* (\f\021\026\r\035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 3 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \030\017\f\031\027\022\036 1. \222\r\024\002\024\007\027\t\005 \ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.02 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \001\027\016\020\021\022\024\022\026\013\027 \033\032\027\030\022\n\023\ \031\032\013 \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\ \022 )0.5(\023\031\f\024\023\031\n\022\213\027\007\025\031\b\031 \020\025\020\024\023\ \031\026\031\016\020 \(\026\025\031\b\031\203\020\n\023\031\032\025\013\235\ \f\031\b\022\024\023\022\007\027)]TJ 0 Tw (-)Tj 0 -1.2 TD (\024\n\022\235 \032\027\b\032\027\024\024\022\031\025\025\013\235 \020\025\ \020\f\022\016\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 3.334 0 Td [( I)4.2(n)-2.8(d)-3.3(e)-5.7(p)-9.3(e)-5(n)-2.7(d)-3.3(e)-5(n)1.4(t)2( p)-0.8(re)-10.9(d)-1(ic)-30.4(t)-1(o)-0.9(r)-12.9(s)2( o)6(f)]TJ /Span<>> BDC 10.431 0 Td ( )Tj EMC [(c)4.8(o)-3.3(l)0.5(o)-2(n)3.6(ic)2( a)-3.1(n)2.4(a)-5.2(s)-12.8(t)-1(o)-2(m)-3.3(o)-0.8(t)-27.1(ic)2( s)8.7(u)-2.8(t)0.9(u)3.6(re)2( f)-6(a)-4.3(i)4.9(l)1.9(u)3.6(re)2( \()63.7(m)3(ul)7.3(t)-27.1(i)-0.9(v)8.3(a)-2.2(r)-37(i)3.5(a)-7.2(te)2( lo)-6.6(g)-16.7(i)8.6(s)-12.8(t)-27.1(ic)2( re)-5.7(g)0.5(re)-20(s)-8.5(s)-10.5(i)0.6(o)-2(n)2( a)-3.1(n)2.4(a)-2.5(l)8.6(y)-3.3(s)-10.4(i)8.6(s)70.2(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 207.1791 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.8721 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 320.565 704.381 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 365.9193 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 479.3051 704.381 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 524.6594 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 206.9291 692.9117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 207.1791 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.8721 692.9117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 320.565 692.9117 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 365.9193 692.9117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 692.9117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 692.9117 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 681.4426 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.8721 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 681.4426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 681.4426 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.9813 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.8721 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 669.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 669.9813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 658.52 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.8721 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 658.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 658.52 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 647.0587 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 207.1791 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 320.565 647.0587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 365.9193 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 479.3051 647.0587 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 8 0 0 8 119.2039 690.0118 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 15.704 0.717 Td (\017\240\b\002\226\004\220\003\002\006\b\013\005 \004\b\004\f\t\213)Tj 19.593 0 Td (\215\b\002\n\002\226\004\220\003\002\006\b\013\005 \004\b\004\f\t\213)Tj -21.487 -1.434 Td (\017\016)Tj 6.108 0 Td (95% \031\034)Tj /T1_3 1 Tf 7.827 0.001 Td (p)Tj /T1_2 1 Tf 5.907 -0.001 Td (\017\016)Tj 6.108 0 Td (95% \031\034)Tj /T1_3 1 Tf 7.827 0.001 Td (p)Tj /T1_0 1 Tf -53.244 -1.433 Td (\222\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\035\017\027,\ \n\022\n\024\035\034/\035)Tj 19.354 0 Td (1,50)Tj 5.966 0 Td (1,22\2261,85)Tj 6.882 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.994 0 Td (1,35)Tj 5.966 0 Td (1,08\2261,69)Tj 7.248 0 Td (0,009)Tj -52.411 -1.433 Td (\200\207\212, \n\n \030\021. \f\021.)Tj 19.354 0 Td (1,34)Tj 5.966 0 Td (1,14\2261,58)Tj 6.882 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.994 0 Td (1,35)Tj 5.966 0 Td (1,10\2261,65)Tj 7.248 0 Td (0,004)Tj -52.411 -1.433 Td (\204\212\202, \027\n\024\035\034/\n\035)Tj 19.354 0 Td (3,06)Tj 5.966 0 Td (1,61\2265,79)Tj 6.882 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.994 0 Td (2,86)Tj 5.966 0 Td (1,25\2266,56)Tj 7.248 0 Td (0,013)Tj /T1_1 1 Tf 7 0 0 7 70.8661 635.574 Tm (\004\032\022\026\027\007\020\025\022\027: \217\237)Tj /Span<>> BDC ( )Tj EMC (\227 \031\023\025\031\213\027\025\022\027 \213\020\025\024\031\021; 95% \ \220\002)Tj /Span<>> BDC ( )Tj EMC [(\227 95% \030\031\021\027\032\022\023\027\f\017\025\013\235 \022\025\023\ \027\032\021\020\f \(\026\027\023\031\030)0.7( \211\020\f\017\030\020\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 616.2701 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \220\022\020\b\025\031\024\023\022\007\027\024\n\020\t \006\027\025\025\ \031\024\023\017 \033\031\n\020\016\020\023\027\f\027\235 \022)Tj /Span<>> BDC ( )Tj EMC [(\022\025\023\027\b\032\020\f\017\025\031\235 )0.5(\026\031\030\027\f\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\033\032\031\b\025\031\016\022\032\031\021\020\025\022\022 \001\003 \(RO\ C-\020\025\020\f\022\016\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.318 0 Td [( D)-12.1(i)1.5(a)-5.1(g)-2.5(n)-2.4(o)-1(s)-14.8(t)-29.1(i)-1.8(c v)6.3(a)-4.5(lu)-3.2(e o)4.1(f i)3.9(n)-4.8(d)-3(i)-1.8(c)3.2(a)-9.1(t)-3(o)-3(r)-14.9(s a)-5.1(n)-4.8(d i)4(n)-0.6(t)-1.6(e)-7.7(g)-1.5(r)3.3(a)-4.5(l m)-5.3(o)-11.9(d)-5.3(e)-6.1(l i)3.9(n p)-2.8(r)-1.9(e)-13(d)-2.9(i)-1.8(c)-32.4(t)-29.1(i)3.9(n)-0.6(g a)-5.1(na)-7.1(s)-14.8(t)-3(o)-4(m)-5.3(o)-1.1(s)-12.5(i)6.6(s f)-8(a)-6.3(i)2.9(lu)1.6(r)-2(e \()30(RO)-11.7(C a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s)68.2(\))]TJ ET /GS2 gs q 1 0 0 1 70.8661 600.9681 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 600.9681 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 600.9681 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 600.9681 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 579.8989 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 579.8989 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 579.8989 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 579.8989 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 568.4376 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 568.4376 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 568.4376 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 568.4376 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 556.9763 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 556.9763 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 556.9763 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 556.9763 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 545.515 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 545.515 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 545.515 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 545.515 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 534.0537 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 534.0537 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 534.0537 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 534.0537 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 522.5925 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 522.5925 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 522.5925 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 522.5925 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 511.1312 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 511.1312 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 511.1312 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 511.1312 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 499.6699 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 499.6699 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 499.6699 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 411.2736 499.6699 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 107.8653 587.5335 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 11.317 0.6 Td (\255\002\206\002\240\b\013\005 \002\220\217\t\212\006\002\f\t\b, )Tj 3.218 -1.2 Td (\214\220\214\002\f\001/\f)Tj 13.124 0.6 Td (\026\224\031, \214\214 \006\003. \217\003.)Tj 14.003 0 Td (\215\031\032, \b\214\002\f\001/\214\f)Tj /T1_0 1 Tf -45.902 -2.033 Td (\215\024\030\024\020)Tj 17.955 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC (15 \n\022\n\024\035\034/\035)Tj 14.192 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC (15 \n\n \030\021. \f\021.)Tj 14.037 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC (4,0 \027\n\024\035\034/\n\035)Tj -46.184 -1.433 Td (AUC \(95% \212\230\))Tj 17.614 0 Td (0,83)Tj /Span<>> BDC ( )Tj EMC (\(0,72\2260,93\))Tj 14.173 0 Td (0,78)Tj /Span<>> BDC ( )Tj EMC (\(0,65\2260,90\))Tj 14.173 0 Td (0,80)Tj /Span<>> BDC ( )Tj EMC (\(0,68\2260,91\))Tj -45.96 -1.433 Td (\232\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034, %)Tj 20.063 0 Td (79,1)Tj 14.173 0 Td (69,8)Tj 14.173 0 Td (74,4)Tj -48.409 -1.433 Td (\222\023\036\006\017\235\017\004\027\024\f\021\034, %)Tj 20.063 0 Td (77,3)Tj 14.173 0 Td (72,7)Tj 14.173 0 Td (77,3)Tj -48.409 -1.433 Td (\215\215\037, %)Tj 20.063 0 Td (87,2)Tj 14.173 0 Td (83,3)Tj 14.173 0 Td (86,5)Tj -48.409 -1.433 Td (\210\215\037, %)Tj 20.063 0 Td (65,4)Tj 14.173 0 Td (55,2)Tj 14.173 0 Td (60,7)Tj -48.409 -1.433 Td (\221\024\004\027\024\f\021\034, %)Tj 20.063 0 Td (78,5)Tj 14.173 0 Td (70,8)Tj 14.173 0 Td (75,4)Tj /T1_1 1 Tf 7 0 0 7 70.8661 488.1852 Tm (\004\032\022\026\027\007\020\025\022\027: \004\031\032\031\b\031\021\013\ \027 \016\025\020\007\027\025\022\t \021\013\240\032\020\025\013 \033\031\ )Tj /Span<>> BDC ( )Tj EMC [(\022\025\030\027\n\024\r \224\030\027\025\020. A)29.5(UC)]TJ /Span<>> BDC ( )Tj EMC [(\227 \033\f\031\212\020\030\017 \033\031\030 R)19.2(OC-\n\032\022\021\031\235, \004\004\037)]TJ /Span<>> BDC ( )Tj EMC (\227 \033\031\f\031\255\022\023\027\f\017\025\020\t \033\032\031\b\025\031\ \024\023\022\007\027\024\n\020\t \006\027\025\025\031\024\023\017; \217\004\ \037)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD [(\031\023\032\022\006\020)49.1(\023\027\f\017\025\020\t \033\032\031\b\025\031\024\023\022\007\027\024\n\ \020\t \006\027\025\025\031\024\023\017. 95% \220\002 \030\f\t \007\r\021\ \024\023\021\022\023\027\f\017\025\031\024\023\022, \024\033\027\006\022\ \203\022\007\025\031)0.6(\024\023\022, \004\004\037, \217\004\037 \022)]TJ /Span<>> BDC ( )Tj EMC (\023\031\007\025\031\024\023\022 \032\020\024\024\007\022\023\020\025\013\ \033\031)Tj /Span<>> BDC ( )Tj EMC (\026\027\023\031\030\r \202\f\031\033\033\027\032\020-)Tj T* (\004\022\032\024\031\025\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1274 56.0378 Tm (96)Tj ET endstream endobj 982 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 983 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 984 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 985 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 986 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1056 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.844 Tw 10 0 0 10 42.5197 469.0919 Tm [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\r\001\017\036\ )0.6(\026\f\f\024\006\017\026\006\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.645 0 Td (\017\f\b\024\007\024\n )Tj 0.18 Tw -18.645 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\235\026\022\021\024\030\027\024\n \026\027\026\035\017\ \036 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.18 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,10\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033\013\017\036 )Tj 0.506 Tw 0 -1.218 TD (\023\026\021\024\020\036\027\036\021\017\004\036\f\022\024\036 \024\002\024\ \f\027\024\r\026\027\017\036 \(\022\035\017\027\017\022\024-\007\036\n\024\ \020\030\026)Tj 0 Tw (-)Tj 0.318 Tw T* (\235\017\004\036\f\022\017\036 \b\026\030\026\022\021\036\030\017\f\021\017\ \022\017, \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\ \036 \023\026)Tj 0 Tw (-)Tj 0.147 Tw T* [(\030\026\n\036\021\030\t, \023\024\022\026\026\021\036\035\017 )0.5(\024\022\f\017\007\026\021\017\r\027\024\020\024 \f\021\030\036\f\f\026,\ \n\026\030\022\036)]TJ 0 Tw (-)Tj 0.344 Tw T* (\030\t \007\036\020\030\026\007\026\006\017\017 \022\024\035\035\026\020\ \036\027\026, \200\207\212\). \204\027\024\020\024\235\026\022\021\024\030\ \027\031\033 )Tj 0.511 Tw T* (\n\024\007\036\035\034 \f\021\030\024\017\035\017 \n\036\021\024\007\024\ \n \023\024\001\026\020\024\r\024\020\024 \r\022\035\033\004\036\027\017\ \016 )Tj 0.182 Tw T* [(\023\030\036\007\017\022\021\024\030\024\r \(for)-37.9(w)-12(ar)-24(d step)-17(wise\). \025\026\004\036\f\021\r\024 \017\021\024\020\024\r\024\005 )]TJ 0.385 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \n\024\007\036\035\ \017 \024\006\036\027\017\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\f\036\r\007\024-R\262 )Tj 0.951 Tw T* (\203\026\005\007\032\036\035\022\036\030\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\033 \216\024\f\n\036\030\026\226\214\036\n\036\ \001\024\031. )Tj 0.181 Tw T* (\215\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\ \024\f\021\034 \024\021\007\036\035\034\027\t\b \022\024\035\017\004\036\ \f\021\r\036\027)Tj 0 Tw (-)Tj 0.124 Tw T* (\027\t\b \023\024\022\026\026\021\036\035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\020\030\026\035\034\027\024\005 \n\024\007\036\035\017 \ \024\006\036\027\017\r\026\035\017 )Tj -0.019 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj /T1_2 1 Tf -0.019 Tc 0.019 Tw [(RO)-19(C)]TJ /T1_1 1 Tf 0 Tc -0.019 Tw 6.197 0 Td (-\026\027\026\035\017\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\201\021\024\n \023\035\024\013\026\007\017 \023\024\007 )Tj /T1_2 1 Tf -0.019 Tc 0.019 Tw [(RO)-19(C)]TJ /T1_1 1 Tf 0 Tc 0 Tw 15.561 0 Td (-)Tj 0.209 Tw -21.758 -1.218 Td [(\022\030\017\r\024\005 \(A)17.1(UC\), 95% \212\230 \017)]TJ /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.209 Tw (-\027\026\004\036\027\017\016. \210\023\021\017\n\026\035\034\027\t\036\ )Tj 0.088 Tw T* [(\023\024\030\024\020\024\r\t\036 )0.5(\027\026\004\036\027\017\016 )0.6(\024\023\030\036\007\036\035\016\035\017 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 15.424 0 Td [(\017\027\007\036\022\f\031 )0.5(\224\007\036\027\026. )]TJ 0.145 Tw -15.424 -1.218 Td (\212\035\016 \r\t\002\030\026\027\027\t\b \023\024\030\024\020\024\r \030\ \026\f\f\004\017\021\t\r\026\035\017 \004\031\r\f\021\r\017\021\036\035\034\ )Tj 0 Tw (-)Tj 0.036 Tw T* (\027\024\f\021\034 \(Se\), \f\023\036\006\017\235\017\004\027\024\f\021\034\ \(Sp\), \023\024\035\024\032\017\021\036\035\034\027\031\033 \023\030\024\ )Tj 0 Tw (-)Tj 0.067 Tw T* (\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\024\f\021\034\ \(\215\215\037\) \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\017\006\026\021\036\035\034\027\031\033 \023\030\024)Tj 0 Tw (-)Tj 0.259 Tw T* (\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\024\f\021\034\ \(\210\215\037\) \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\004\017\f\035\036\027\017\036\n 95% )Tj 0.152 Tw T* (\212\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \025\035\024\023\023\036\030\026\226\215\017\030\f\ \024\027\026. \215\030\024\020\027\024\f\021\017\004\036\f\022\017\036 )Tj 0.594 Tw T* (\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \017\027\021\036\020\ \030\026\035\034\027\024\005 \n\024\007\036\035\017 \024\006\036\027\017\ \r\026\035\017 )Tj 0.103 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\036\027\017\016\n \023\030\036\007\f\022\026\026\027\027\024\ \005 \r\036\030\024\016\021\027\024\f\021\017 \203\202, \023\024\035\031\ )Tj 0 Tw (-)Tj 0.289 Tw T* (\004\036\027\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\024\005 \035\024\020\017\f\ \021\017\004\036\f\022\024\005 \030\036\020\030\036\f)Tj 0 Tw (-)Tj 0.248 Tw T* (\f\017\017. \222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\t\n\017 \f\004\017\021\026\035\017 \030\036\031\035\034\021\026\021\ \t )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 140.2859 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.388 Tw 10 0 0 10 42.5197 115.9299 Tm (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\004\036\027\ \t 65 \023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b )Tj 0.007 Tw T* (37)Tj /Span<>> BDC ( )Tj EMC [(\(56,9%\) )0.5(\n\031\032\004\017\027 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.833 0 Td (28)Tj /Span<>> BDC ( )Tj EMC [(\(43,1%\) \032\036\027\013\017\027. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 9.326 0 Td (\024\f\027\024\r\027\024\005 )Tj 0.175 Tw -18.159 -1.218 Td (\020\030\031\023\023\036 \(\203\202\) \002\t\035\024 25)Tj /Span<>> BDC ( )Tj EMC (\(58,1%\) \n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (18)Tj /Span<>> BDC ( )Tj EMC (\(41,9%\) )Tj 0.71 Tw T* (\032\036\027\013\017\027; \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 12 \(54,5%\) )Tj 0.061 Tw 23.244 38.97 Td (\017)Tj /Span<>> BDC ( )Tj EMC (10)Tj /Span<>> BDC ( )Tj EMC (\(45,5%\), \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.061 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,99\). \200\024\030\026\f\021 \023\026)Tj 0 Tw (-)Tj 0.122 Tw T* (\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\026\004\017\n\024 \027\036 \030\026\035\ \017\004\026\035\f\016: \n\036\007\017\026\027\026 )Tj 0.033 Tw T* [(\(Me )0.5([Q1\226Q3]\) )0.6(\f\024\f\021\026\r\017\035\026 )0.5(63,0 )0.6([57,4\22669,0] )0.5(\020\024\007\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.94 0 Td (\020\030\031\023)Tj 0 Tw (-)Tj 0.102 Tw -19.94 -1.218 Td (\023\036 \203\202 \017)Tj /Span<>> BDC ( )Tj EMC (61,2)Tj /Span<>> BDC ( )Tj EMC ([56,9\22670,0] \020\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \002\036 \027\036\f\024)Tj 0 Tw (-)Tj T* (\f\021\024\016\021\036\035\034\027\024\f\021\017 \()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,91\).)Tj 0.311 Tw T* [(\212\035\017\021\036\035\034\027\024\f\021\034 )0.5(\024\023\036\030\026\006\017\017 \002\t\035\026 \f\024\023\024\f\021\026\ \r\017\n\024\005: )0.5(144,9 )]TJ 0.152 Tw T* ([132,3\226155,1] \n\017\027. \023\030\024\021\017\r 136,3 [124,8\226150,\ 2] \n\017\027. )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf 0.114 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,182\), \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n \017\027\021\030\026\024\023\036\030\026\006\017\024\027\ \027\024\005 \022\030\024\r\024)Tj 0 Tw (-)Tj 0.131 Tw T* (\023\024\021\036\030\017)Tj /Span<>> BDC ( )Tj EMC 3.231 0 Td [(\227 )0.5(280 )0.5([222,7\226337,3] )0.6(\n\035 )0.5(\023\030\024\021\017\r )0.6(260 )0.5([207,4\226)]TJ 0.301 Tw -3.231 -1.218 Td (312,6] \n\035 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.301 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,360\). \221\026\022\017\n \024\002\030\026\024\n, \020\030\031\023\023\ \t \027\036 )Tj 0.077 Tw T* (\024\021\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\n \002\026\024\r\t\n \022\035\017\027\017\022\024\ -\007\036\n\024\020\030\026)Tj 0 Tw (-)Tj 0.405 Tw T* [(\235\017\004\036\f\022\017\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.901 0 Td [(\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\n )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022\026\n )]TJ 0 Tw -5.901 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.121 Tw T* (\211\030\024\r\036\027\034 \204\212\202 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \f\024\f\021\026\r\017\035 4,4 [3,9\2264,7] )Tj 0.268 Tw T* (\027\n\024\035\034/\n\035, \004\021\024 \002\t\035\024 \f\031\013\036\f\021\ \r\036\027\027\024 \r\t\001\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.122 Tw T* (\006\017\036\027\021\024\r \002\036 \203\202 \(3,1 [2,4\2263,6] \027\n\024\ \035\034/\n\035; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.122 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj -0.036 Tw T* (\025\024\027\006\036\027\021\030\026\006\017\016 \007\017\036\027\024\r\t\ \b \022\024\027\255\033\020\026\021\024\r \(\212\025\) \021\026\022\032\036\ \002\t\035\026 )Tj 0.284 Tw T* (\027\026\004\017\021\036\035\034\027\024 \023\024\r\t\001\036\027\026 \r\ )Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \203\202 \(3,1 [2,8\2263,4] )Tj 0.107 Tw T* [(\023\030\024\021\017\r )0.5(1,9 [1,7\2262,1] )0.5(\n\n\024\035\034/\n\035; )]TJ /T1_2 1 Tf 0 Tw 13.441 0 Td (p)Tj /T1_1 1 Tf 0.107 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC 1.657 0 Td [(0,001\), \021\024\020\007\026 )0.5(\022\026\022 )]TJ 0.25 Tw -15.098 -1.218 Td (\031\030\024\r\036\027\034 \026\f\022\024\030\002\017\027\024\r\024\005 \ \022\017\f\035\024\021\t \024\022\026\026\035\f\016 \f\021\026\021\017\f\ \021\017)Tj 0 Tw (-)Tj 0.244 Tw T* (\004\036\f\022\017 \027\026\004\017\n\024 \027\017\032\036 \(52,4 [47,6\ \22656,4] \023\030\024\021\017\r 65,5 )Tj 0 Tw T* ([59,7\22670,4] \n\n\024\035\034/\035; )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\).)Tj 0.295 Tw T* (\211 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \030\036\020\017\f\021\030\017\030\024\r\026\035\024\f\034 \002\ \024\035\036\036 \r\t\f\024\022\024\036 )Tj 0.203 Tw T* (\f\024\007\036\030\032\026\027\017\036 \035\026\022\021\026\021\026 \(2,\ 7 [2,3\2263,1] \023\030\024\021\017\r 1,6 [1,4\226)Tj 0.13 Tw T* (1,8] \n\n\024\035\034/\035; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.13 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026 )Tj 0.15 Tw T* (\(18,0 [15,7\22619,6] \023\030\024\021\017\r 12,7 [11,1\22614,8] \n\022\n\ \024\035\034/\035; )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.287 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\027\021\030\026\006\017\016 \f\036\030\024\021\024\027\ \017\027\026, \027\026\023\030\024\021\017\r, )Tj 0.357 Tw T* (\002\t\035\026 \f\027\017\032\036\027\026 \(0,6 [0,5\2260,7] \023\030\024\ \021\017\r 0,9 [0,8\2260,9] )Tj 0 Tw T* (\n\022\n\024\035\034/\035; )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\).)Tj 0.217 Tw T* (\200\027\031\021\030\017\002\030\033\001\027\024\036 \007\026\r\035\036\027\ \017\036 \(\200\207\212\) \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 )Tj 0.066 Tw T* [(\007\024\f\021\017\020\026\035\024 )0.5(16,1 [14,2\22617,9] )0.5(\n\n \030\021. )0.5(\f\021. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.53 0 Td [(\027\026\004\017\n\024 )0.5(\023\030\036)]TJ 0 Tw (-)Tj 0.114 Tw -16.53 -1.218 Td (\r\t\001\026\035\024 \f\024\024\021\r\036\021\f\021\r\031\033\013\017\005\ \023\024\022\026\026\021\036\035\034 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \002\036 )Tj 0.23 Tw T* [(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.5(\026\027\026\f\021\024\n\024\026 \(10,5 [8,8\22615,1]] \n\n )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.045 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \202\f\022\025\022\007\027\024\n\022\027 \022)Tj /Span<>> BDC ( )Tj EMC (\f\020\240\031\032\020\023\031\032\025\013\027 \200\020\032\020\n\023\027\ \032\022\024\023\022\n\022 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\017\005 \023\ \031\f\024\023\031\n\022\213\027\007\025\031\b\031 \020\025\020\024\023\031\ )Tj 0 Tw (-)Tj 0 -1.2 TD (\026\031\016\020 \022)Tj /Span<>> BDC ( )Tj EMC (\240\027\016 \025\027\233 \(\031\030\025\031\203\020\n\023\031\032\025\013\ \235 \020\025\020\f\022\016\), Me [Q1\231Q3])Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.017 Tc -0.029 Tw T* [(\020a)-25.3(b)-30.8(l)-28.7(e)-17( 1)-14.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.046 Tw 3.288 0 Td [( C)1.2(li)3.9(n)1.7(i)-1.8(c)3.2(a)-4.5(l a)-5.1(n)-4.8(d l)-1.1(a)-0.9(b)-10.1(o)-3(r)3.3(a)-9.2(t)-3(o)-3(r)-43.7(y c)-2.5(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.7(s)-14.9(t)-29(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s w)-26.7(i)-3.4(t)-10.5(h a)-5(n)-4.9(d w)-26.7(i)-3.4(t)-10.6(h)-2.4(o)-3.4(u)-4.8(t c)2.8(o)-5.3(l)-1.6(o)-3(r)-2(e)-10.8(c)-32.4(t)-2(a)-4.5(l a)-5.1(na)-7.2(s)-14.8(t)-3(o)-4(m)-5.2(o)-2.9(t)-29.1(i)-1.8(c le)-7.5(a)-2.7(k)11.3(a)-5.2(g)-6.8(e \()64.8(u)0.7(n)1.6(i)-2.8(v)6.3(a)-4.2(r)-39(i)1.5(a)-9.2(t)-1.6(e a)-5.1(na)-4.5(l)6.7(y)-5.3(s)-12.5(i)6.6(s)68.2(\))29.3(, )]TJ -0.065 Tc 0.065 Tw -3.288 -1.2 Td [(M)-67(e)-65( [)-21.3(Q)-47.3(1)-25.5(\231)-102.1(Q)-65.5(3])]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 212.8484 693.581 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 326.2343 693.581 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 693.581 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 682.1118 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 670.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 682.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 682.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 682.1118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 670.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 670.6505 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 670.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 670.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 670.6505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.1892 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 659.1892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 659.1892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 659.1892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 647.7279 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 647.7279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 647.7279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 647.7279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 636.2667 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 636.2667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 636.2667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 636.2667 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 624.8054 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 624.8054 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 624.8054 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 624.8054 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 613.3441 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 602.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 613.3441 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 613.3441 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 613.3441 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 602.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 601.8828 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 601.8828 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 601.8828 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 601.8828 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 590.4215 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 590.4215 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 590.4215 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 590.4215 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 578.9602 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 578.9602 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 578.9602 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 578.9602 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 567.499 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 567.499 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 567.499 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 567.499 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 556.0377 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 556.0377 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 556.0377 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 556.0377 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 544.5764 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 544.5764 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 544.5764 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 544.5764 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 533.1151 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 533.1151 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 533.1151 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 533.1151 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 521.6538 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 212.8484 521.6538 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 521.6538 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 521.6538 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 8 0 0 8 107.8653 684.9464 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 17.712 0 Td (\025\032 \()Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj 11.2 0 Td (\224\r\213 \002\217\f\002\202\b\r\b\t\005 \()Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (22\))Tj /T1_5 1 Tf 14.52 0 Td (p)Tj /T1_4 1 Tf (-value)Tj /T1_1 1 Tf -51.215 -1.433 Td (\215\024\035\024\r\024\030\026\f\021\027\t\036 \b\026\030\026\022\021\036\ \030\017\f\021\017\022\017)Tj 0 -1.433 TD (\200\024\030\026\f\021, \035\036\021)Tj 24.7 0 Td (63,0 [57,4\22669,0])Tj 14.173 0 Td (61,2 [56,9\22670,0])Tj 12.829 0 Td (0,914)Tj -51.703 -1.433 Td (\204\031\032\004\017\027\t, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 26.163 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(58,1\))Tj 14.173 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(54,5\))Tj 11.366 0 Td (0,797)Tj -51.703 -1.433 Td (\230\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\036 \023\024\ \022\026\026\021\036\035\017)Tj T* (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017, \n\017\027.)Tj 23.95 0 Td (144,9 [132,3\226155,1])Tj 14.173 0 Td (136,3 [124,8\226150,2])Tj 13.579 0 Td (0,182)Tj -51.703 -1.433 Td (\025\030\024\r\024\023\024\021\036\030\016, \n\035)Tj 24.293 0 Td (280 [222,7\226337,3])Tj 14.173 0 Td (260 [207,4\226312,6])Tj 13.237 0 Td (0,360)Tj -51.703 -1.433 Td (\214\026\002\024\030\026\021\024\030\027\t\036 \023\024\022\026\026\021\ \036\035\017 \(2\2263-\017 \f\031\021\022\017\))Tj T* (\204\212\202, \027\n\024\035\034/\n\035)Tj 25.45 0 Td (4,4 [3,9\2264,7])Tj 14.173 0 Td (3,1 [2,4\2263,6])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\212\017\036\027\024\r\t\036 \022\024\027\255\033\020\026\021\t, \n\n\024\ \035\034/\n\035)Tj 25.45 0 Td (3,1 [2,8\2263,4])Tj 14.173 0 Td (1,9 [1,7\2262,1])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\202\f\022\024\030\002\017\027\024\r\026\016 \022\017\f\035\024\021\026,\ \n\022\n\024\035\034/\035)Tj 24.7 0 Td (52,4 [47,6\22656,4])Tj 14.173 0 Td (65,1 [59,7\22670,4])Tj 12.463 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\214\026\022\021\026\021, \n\n\024\035\034/\035)Tj 25.45 0 Td (2,7 [2,3\2263,1])Tj 14.173 0 Td (1,6 [1,4\2261,8])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\222\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\035\017\027,\ \n\022\n\024\035\034/\035)Tj 24.7 0 Td (18,0 [15,7\22619,6])Tj 14.173 0 Td (12,7 [11,1\22614,8])Tj 12.463 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\222\036\030\024\021\024\027\017\027, \n\022\n\024\035\034/\035)Tj 25.45 0 Td (0,6 [0,5\2260,7])Tj 14.173 0 Td (0,9 [0,8\2260,9])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\200\207\212, \n\n \030\021. \f\021.)Tj 24.7 0 Td (16,1 [14,2\22617,9])Tj 14.423 0 Td (10,5 [8,8\22615,1])Tj 12.213 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj /T1_2 1 Tf 7 0 0 7 42.5197 510.1691 Tm (\004\032\022\026\027\007\020\025\022\027: p)Tj /Span<>> BDC ( )Tj EMC (\227 \033\031)Tj /Span<>> BDC ( )Tj EMC [(U-\n\032\022\023\027\032\022\005 \215\020\025\025\020\231\210)50.3(\022\023\025\022 \030\f\t \n\031\f\022\007\027\024\023\021\027\025\025\013\ \200 \033\032\022\016\025\020\n\031\021 \022)]TJ /Span<>> BDC ( )Tj EMC (\250\262-\n\032\022\023\027\032\022\005 \004\022\032\024\031\025\020 \(\033\ \032\022 \025\027\031\240\200\031\030\022\026\031\024\023\022)Tj /Span<>> BDC ( )Tj EMC (\227 \023\031\007\025\031\026\r \n\032\022\023\027\032\022\005 )Tj 0 -1.2 TD (\214\022\213\027\032\020\) \030\f\t \n\020\007\027\024\023\021\027\025\025\ \013\200 \033\032\022\016\025\020\n\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.7895 56.0378 Tm (95)Tj ET endstream endobj 1055 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.023 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\024\035\035\026\020\036\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \r\027\031\021\030\017\002\030\033\001\027\024\020\ \024 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027)Tj 0 Tw (-)Tj 0.052 Tw 0 -1.218 TD [(\027\036\005 )0.5(\007\017\026\020\027\024\f\021\017\022\036 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\021\024\035\f\021\024\022\017\001\036\004\027\t\b )]TJ 0 Tw T* (\026\027\026\f\021\024\n\024\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 663.9399 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 2.106 Tw 10 0 0 10 70.8661 639.5839 Tm (\200\t\023\024\035\027\036\027\024 \030\036\021\030\024\f\023\036\022\021\ \017\r\027\024\036 \024\002\f\036\030\r\026\006\017\024\027)Tj 0 Tw (-)Tj 0.727 Tw T* (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \253\f\035\031\004\026\005-\022\024\027\021\030\024\035\ \034\273. )Tj 0.213 Tw T* [(\215\030\024\026\027\026\035\017\017\030\024\r\026\027\t )0.5(\017\f\021\024\030\017\017 \002\024\035\036\027\017 65 \023\026\006\017\ \036\027\021\024\r, )]TJ 0.1 Tw 0 -1.218 TD (\023\036\030\036\027\036\f\001\017\b \023\035\026\027\024\r\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\030\024\004\036\027\027\t\036 \030\036\036\022\006\017\017 \021\ \024\035)Tj 0 Tw (-)Tj -0.049 Tw 0 -1.218 TD (\f\021\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \023\036\030\r\017\004\027\ \024\020\024 \026\027\026\f\021\024\n\024\026 )Tj 0.021 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \007\024\002\030\024\022\026\004\036\f\021\r\036\027\ \027\t\b )0.5(\026\002\024\035\036\r\026\027\017\005 \(\007\024\035\017\b\024)]TJ 0 Tw (-)Tj 0.222 Tw T* (\f\017\020\n\026, \007\024\035\017\b\024\022\024\035\024\027, \n\036\020\ \026\007\024\035\017\b\024\f\017\020\n\026, \007\024\035\017\b\024\f\017\ \020\n\026 )Tj 0.089 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\036\n \f\017\027\007\030\024\n \215\026\005\ \030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007.\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \035\017\022\r\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\007\026\006\017\017 \021\024\035\f\021\024\022\017\001\036\004\027\t\b \ \f\021\024\n \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 2021\2262025 \020\020.)Tj 0 -1.218 TD (\025\030\017\021\036\030\017\017 \r\022\035\033\004\036\027\017\016:)Tj 0 -1.218 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\r\024\030\026\f\021 \f\021\026\030\001\036 18 \035\036\021;)Tj -0.01 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-277( )]TJ EMC 1.056 0 Td (\030\036\036\022\006\017\016 \024\002\024\007\024\004\027\024\005 \022\017\ \001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \026\027\026)Tj 0 Tw (-)Tj 0.261 Tw T* (\f\021\024\n\024\026 \253\022\024\027\036\006-\r-\022\024\027\036\006\273\ \017\035\017 \253\002\024\022-\r-\002\024\022\273, \035\017\002\024 )Tj 0.118 Tw T* (\035\017\022\r\017\007\026\006\017\016 \022\024\035\024\f\021\024\n\t \f\ )Tj /Span<>> BDC ( )Tj EMC (\027\026\035\024\032\036\027\017\036\n \021\024\035\f\021\024-\021\024\035\ )Tj 0 Tw (-)Tj T* (\f\021\024\022\017\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\ \026;)Tj 0.506 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )239( )]TJ EMC 1.056 0 Td (\007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\005 \b\026\030\ \026\022\021\036\030 \026\002\024\035\036\r\026\027\017\016 \(\024\021)Tj 0 Tw (-)Tj 0.11 Tw T* (\f\031\021\f\021\r\017\036 \022\024\035\024\030\036\022\021\026\035\034\027\ \024\020\024 \030\026\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \035\024\022\026\004\036)Tj 0 Tw (-)Tj T* (\f\021\r\036\027\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\ \005\);)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\017\027\235\024\030\n\017\030\024\r\026\027\027\024\036 \f\024\020\035\026\ \f\017\036 \023\026\006\017\036\027\021\026.)Tj -1.056 -1.218 Td (\025\030\017\021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016:\ )Tj 0.081 Tw T* (\226)Tj /Span<>> BDC [( )-186( )]TJ EMC 1.056 0 Td [(\035\024\022\026\004\036\f\021\r\036\027\027\t\036 )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 )0.6(\(\007\035\016 )0.5(\017\f\022\035\033\004\036)]TJ 0 Tw (-)Tj T* (\027\017\016 \023\026\030\026\027\036\024\023\035\026\f\021\017\004\036\f\ \022\024\020\024 \r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\022\036\030\t\);)Tj -0.059 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-326( )]TJ EMC 1.056 0 Td [(\030\026\f\023\030\024\f\021\030\026\027\201\027\027\t\005 )0.5(\023\036\030\017\021\024\027\017\021 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \024\023\036\030\026\006\017\017;)Tj 0.029 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-238( )]TJ EMC 1.056 0 Td (\021\016\032\201\035\t\036 \f\024\023\031\021\f\021\r\031\033\013\017\036\ \026\002\024\035\036\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \007\036)Tj 0 Tw (-)Tj T* (\022\024\n\023\036\027\f\026\006\017\017, \f\031\013\036\f\021\r\036\027\ \027\024 \r\035\017\016\033\013\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024;)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\024\021\f\031\021\f\021\r\017\036 \022\035\033\004\036\r\t\b \035\026\002\ \024\030\026\021\024\030\027\t\b \023\024\022\026\026\021\036\035\036\005\ .)Tj 0.06 Tw -1.056 -1.218 Td (\215\026\006\017\036\027\021\t \002\t\035\017 \030\026\007\036\035\036\027\ \t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \020\030\031\023\023\t. \210\f\027\024\r\027\031\033 )Tj 0.167 Tw T* (\020\030\031\023\023\031 \f\024\f\021\026\r\017\035\017 43 \023\026\006\017\ \036\027\021\026, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n )Tj 0.115 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \(\007\024 14-\b \f\031\021\024\022\) \030\026\r\017\ )Tj 0 Tw (-)Tj 0.182 Tw T* (\035\026\f\034 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \034 \021\024\035\f\021\024\022\017\001\036\004\027\024\020\024 \026\027\ \026\f\021\024\n\024)Tj 0 Tw (-)Tj 0.004 Tw T* (\026. \212\026\027\027\t\005 \007\017\026\020\027\024 \002\t\035 \r\036\ \030\017\235\017\006\017\030\024\r\026\027 \022\035\017\027\017\004\036\f\ \022\017, )Tj 0.094 Tw T* [(\030\036\027\021\020\036\027\024\035\024\020\017\004\036\f\022\017 )0.6(\(\r\t\b\024\007 )0.5(\022\024\027\021\030\026\f\021\026\), )0.6(\220\027\007\024\f\022\024\023\017\004\036)]TJ 0 Tw (-)Tj T* (\f\022\017 \017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\035\026\023\026\030\024\021\024\n\017\017.)Tj 0.006 Tc 0.278 Tw T* [(\206\030\031\023\023\026 \f\030\026\r\027\036\027\017\016 \235\024\030\n\ \017\030\024\r\026\035\026\f\034 \030\036\021\030\024\f\023\036\022\021\017\ \r\027\024)6( )]TJ 0.077 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\036\030\036\027\201\f\001\017\b\ \026\027\026\035\024\020\017\004\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \030\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.134 Tw T* (\036\022\006\017\024\027\027\t\036 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\031\007\024\r\035\036\021\r\024\030\016\r\001\017\b \021\036\n)6( )]TJ 0.121 Tw T* (\032\036 \022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\027\017\ \016 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\002\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.238 Tw T* (\030\036 \031\004\017\021\t\r\026\035\017\f\034 \f\024\023\024\f\021\026\ \r\017\n\024\f\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\031, \r\024\030\026\f\021\031)6( )]TJ 0.37 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\021\017\023\031 \024\023\036\030\026\006\017\017 \(\031\030\024\r\036\027\ \034 \026\027\026\f\021\024\n\024\026\). \217\026\027\017\006\026)6( )]TJ 0.232 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \n\036\032\007\031 \023\026\006\017\036\027\021\ \026\n\017 \007\r\031\b \020\030\031\023\023 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.022 Tw 0 -1.218 TD [(\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \027\036 \023\030\036\r\ \t\001\026\035\026 5 \035\036\021; \f\031\013\036\f\021\r\036\027\027\t\b\ )6( )]TJ 0.184 Tw 0 -1.218 TD (\030\026\035\017\004\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\f\021\017 \024\023\036\030\026\006\017\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\031 \017\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.248 Tw 0 -1.218 TD [(\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \022\030\024\ \r\024\023\024\021\036\030\017 \021\026\022\032\036 \027\036 \024\021\n\036\ \004\036\027\024)6( )]TJ 0 Tc 0 Tw 0 -1.218 TD (\()Tj /T1_2 1 Tf 0.376 0 Td (p)Tj /T1_0 1 Tf 0.006 Tc /Span<>> BDC 0.484 0 Td ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (0,05\).)Tj 0 Tc -0.023 Tw -0.86 -1.218 Td [(\221\026\022\017\n \024\002\030\026\024\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\r\022\035\033\004\036\027\026 )0.5(\r\f\016 )0.5(\007\024\f\021\031\023)]TJ 0 Tw (-)Tj 0.077 Tw 0 -1.218 TD (\027\026\016 \f\024\r\024\022\031\023\027\024\f\021\034 \023\026\006\017\ \036\027\021\024\r, \031\007\024\r\035\036\021\r\024\030\016\033\013\017\ \b \022\030\017)Tj 0 Tw (-)Tj 0.229 Tw T* (\021\036\030\017\016\n, \026)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\027\t\005 \023\036\030\017\024\007, \002\036 \007\ \024\023\024\035\027\017\021\036\035\034\027\t\b )Tj 0.168 Tw 23.244 64.543 Td (\253\024\004\017\f\021\024\022\273 \024\f\027\024\r\027\024\005 \020\030\ \031\023\023\t; \030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 \023\ \024\007)Tj 0 Tw (-)Tj T* (\002\024\030 \022\026\f\026\035\f\016 \021\024\035\034\022\024 \020\030\031\ \023\023\t \f\030\026\r\027\036\027\017\016.)Tj 0.205 Tw T* (\211 \r\f\036\b \023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027)Tj 0 Tw (-)Tj T* (\027\024\020\024 \023\036\030\017\024\007\026 \024\006\036\027\017\r\026\ \035\017 \f\035\036\007\031\033\013\017\036 \023\024\022\026\026\021\036\ \035\017:)Tj 0.264 Tw T* (\251)Tj /Span<>> BDC [( )-3( )]TJ EMC 1 0 Td (\n\026\030\022\036\030\t \024\022\f\017\007\026\021\017\r\027\024\020\024\ \f\021\030\036\f\f\026: \n\026\035\024\027\024\r\t\005 \007\017)Tj 0 Tw (-)Tj T* (\026\035\034\007\036\020\017\007 \(\204\212\202\), \007\017\036\027\024\r\ \t\036 \022\024\027\255\033\020\026\021\t \(\212\025\);)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\026\027\021\017\024\022\f\017\007\026\027\021\027\026\016 \026\013\017\ \021\026: \026\f\022\024\030\002\017\027\024\r\026\016 \022\017\f\035\024\ \021\026;)Tj 1.203 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )936( )]TJ EMC 1 0 Td (\n\026\030\022\201\030 \007\036\020\030\026\007\026\006\017\017 \022\024\ \035\035\026\020\036\027\026: \f\r\024\002\024\007\027\t\005 )Tj 0 Tw 0 -1.218 TD (\024\022\f\017\023\030\024\035\017\027;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\035\026\022\021\026\021 \023\035\026\n\t \022\026\022 \017\027\007\017\ \022\026\021\024\030\026 \021\022\026\027\036\r\024\005 \020\017\023\024\ \022\f\017\017;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\r\027\031\021\030\017\002\030\033\001\027\024\036 \007\026\r\035\036\027\ \017\036 \(\200\207\212\).)Tj 0.116 Tw -1 -1.218 Td (\211\030\024\r\036\027\034 \204\212\202 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 \024\023\030\036\007\036\ \035\016\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.147 Tw 0 -1.218 TD (\026\022\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (2-\021\017\024\002\026\030\002\017\021\031\030\024\r\024\005 \022\017\f\035\ \024\021\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\f\021\030\026\006\017)Tj 0 Tw (-)Tj 0.364 Tw 0 -1.218 TD (\036\005 \024\023\021\017\004\036\f\022\024\005 \023\035\024\021\027\024\ \f\021\017 \f\023\036\022\021\030\024\235\024\021\024\n\036\021\030\017\004\ \036\f\022\017. )Tj 0.07 Tw 0 -1.218 TD (\212\017\036\027\024\r\t\036 \022\024\027\255\033\020\026\021\t \024\006\ \036\027\017\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\005 \n\036)Tj 0 Tw (-)Tj 0.196 Tw 0 -1.218 TD (\021\024\007\017\022\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\206\026\r\030\017\035\024\r\031. \025\024\027\006\036\027\021\030\026\006\ \017\033 \026\f\022\024\030\002\017\027\024\r\024\005 )Tj 0.221 Tw 0 -1.218 TD (\022\017\f\035\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 \024\023\030\036\007\036\ \035\016\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 )Tj 0.173 Tw 0 -1.218 TD (\221\017\035\034\n\026\027\f\026. \211\030\024\r\036\027\034 \f\r\024\002\ \024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t)Tj 0 Tw (-)Tj 0.126 Tw 0 -1.218 TD (\r\024\030\024\021\022\036 \022\030\024\r\017 \017\f\f\035\036\007\024\r\ \026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\036 \207\036\030\020\n\026\027\026\226)Tj 0.087 Tw 0 -1.218 TD (\214\024\022\f\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\017\235\017\022\026\006\017\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\221\036\021\016\027\036\031. \211\030\024\r\036\027\034 \035\026\022\021\ \026)Tj 0 Tw (-)Tj 0.152 Tw 0 -1.218 TD (\021\026 \023\035\026\n\t \024\023\030\036\007\036\035\016\035\017 \022\ \024\035\024\030\017\n\036\021\030\017\004\036\f\022\017\n \n\036\021\024\ \007\024\n )Tj 0.315 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\022\006\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\024\022\f\017\007\017\235\036\027\017\035\024\n. \200\036\ \035\017\004\017\027\031 \r\027\031)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\021\030\017\002\030\033\001\027\024\020\024 \007\026\r\035\036\027\017\016\ \(\200\207\212, \n\n \030\021. \f\021.\) \024\006\036\027\017\r\026\035\ \017 )Tj -0.007 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\005 \n\036\021\024\007\017\022\036\ \004\036\030\036 \n\024\004\036\r\024\005 \023\031\t\030\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.043 Tw 0 -1.218 TD [(\023\024\035\034\024\r\026\027\017\036\n \020\030\026\007\031\017\030\024\ \r\026\027\027\024\005 )0.5(\f\017\f\021\036\n\t, \r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\017 )Tj -0.024 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\026 \035\201\032\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\023\017\027\036, \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\007\024\b\036, \004\036\030\036 5\22610 \n\017\027\031\021 )Tj -0.007 Tw 0 -1.218 TD (\023\024\f\035\036 \022\026\021\036\021\036\030\017\026\006\017\017, \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \r\r\036\007\201\027\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\004\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\024\005 \023\031\t\030\034 \030\026\f\021\r\024\030\026 \027\036 \002\ \024\035\036\036 25 \n\035.)Tj /T1_3 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_0 1 Tf 0.053 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\024\002\030\026\002\024\021\022\026 )0.5(\007\026\027\027\t\b )0.6(\023\030\024\r\024\007\017\035\026\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.803 0 Td (\017\f)Tj 0 Tw (-)Tj 0.104 Tw -20.803 -1.218 Td [(\023\024\035\034\024\r\026\027\017\036\n \023\026\022\036\021\024\r IBM\ SPS)17(S S)15(t)15(a)15(t)-32(ist)-32(ics 22.0 \(IBM )]TJ -0.034 Tw 0 -1.218 TD [(Cor)-24(p., \222\231\202\) \017)]TJ /Span<>> BDC ( )Tj EMC [(MedCal)16(c \(MedCal)16.1(c S)-16(of)-28(t)-32(w)-12(ar)-23.9(e L)45(td., \210\f\021\036\027\007\036, )]TJ -0.057 Tw 0 -1.218 TD (\207\036\035\034\020\017\016\). \203\024\030\n\026\035\034\027\024\f\021\ \034 \030\026\f\023\030\036\007\036\035\036\027\017\016 \022\024\035\017\ \004\036\f\021\r\036\027)Tj 0 Tw (-)Tj 0.302 Tw 0 -1.218 TD (\027\t\b \007\026\027\027\t\b \023\030\024\r\036\030\016\035\017 \022\030\ \017\021\036\030\017\036\n \231\026\023\017\030\024\226\211\017\035\022\026\ . )Tj 0.104 Tw 0 -1.218 TD (\222)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \024\021\027\024\f\017\021\036\035\034\027\024 \027\ \036\002\024\035\034\001\024\020\024 \024\002\255\201\n\026 \r\t\002\024\ \030\022\017 )Tj 0.216 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\027\t\b \024\021\022\035\024\027\036\027\017\005 \ \024\021 \027\024\030\n\026\035\034\027\024\020\024 \030\026\f\023\030\036\ )Tj 0 Tw (-)Tj 0.503 Tw 0 -1.218 TD [(\007\036\035\036\027\017\016 )0.6(\002\024\035\034\001\017\027\f\021\r\024 )0.5(\022\024\035\017\004\036\f\021\r\036\027\027\t\b )0.6(\023\030\017\027\026\022\024\r )]TJ 0.098 Tw 0 -1.218 TD (\024\023\017\f\t\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \n\036\007\017\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\022\r\026\030\021\017\035\034\027\024\020\024 \030\026)Tj 0 Tw (-)Tj 0.051 Tw 0 -1.218 TD (\n\026\b\026)Tj /Span<>> BDC ( )Tj EMC (\227 Me [Q1\226Q3]. \212\035\016 \f\030\026\r\027\036\027\017\016 \022\024\ \035\017\004\036\f\021\r\036\027\027\t\b )Tj 0.045 Tw 0 -1.218 TD (\023\030\017\027\026\022\024\r \n\036\032\007\031 \007\r\031\n\016 \027\ \036\026\r\017\f\017\n\t\n\017 \020\030\031\023\023\026\n\017 \017\f)Tj 0 Tw (-)Tj 0.147 Tw 0 -1.218 TD [(\023\024\035\034\024\r\026\035\017 )0.6(\027\036\023\026\030\026\n\036\021\030\017\004\036\f\022\017\005 )0.6(U-\022\030\017\021\036\030\017\005 )0.5(\204\026\027\027\026\226)]TJ 0.084 Tw 0 -1.218 TD (\211\017\021\027\017. \025\026\004\036\f\021\r\036\027\027\t\036 \023\030\ \017\027\026\022\017 \023\030\036\007\f\021\026\r\035\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.325 Tw 0 -1.218 TD (\026\002\f\024\035\033\021\027\t\b \027\026\004\036\027\017\005 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.325 Tw (\) \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\036\005 \(%\); \030\026\035\017\004\017\016 )Tj 0.126 Tw 0 -1.218 TD (\n\036\032\007\031 \020\030\031\023\023\026\n\017 \024\006\036\027\017\r\ \026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \245\262-\022\030\017\021\036\030\017\016 )Tj 0.113 Tw 0 -1.218 TD [(\215\017\030\f\024\027\026, )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.929 0 Td [(\024\032\017\007\026\036\n\t\b )0.6(\004\026\f\021\024\021\026\b)]TJ /Span<>> BDC ( )Tj EMC 8.96 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.845 0 Td [(5 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 1.665 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC 0.845 0 Td [(20% )0.5(\016\004\036)]TJ 0 Tw (-)Tj -18.245 -1.218 Td (\036\022)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \021\024\004\027\024\020\ \024 \022\030\017\021\036\030\017\016 \205\017\001\036\030\026.)Tj 0.247 Tw 0 -1.218 TD (\212\035\016 \017\031\004\036\027\017\016 \235\026\022\021\024\030\024\r\ \030\017\f\022\026 \203\202 \r\t\023\024\035\027\016\035\017 \031\027\017\ )Tj 0 Tw (-)Tj 0.393 Tw 0 -1.218 TD (\r\026\030\017\026\027\021\027\t\005 \002\017\027\026\030\027\t\005 \035\ \024\020\017\f\021\017\004\036\f\022\017\005 \030\036\020\030\036\f\f\017\ \024\027)Tj 0 Tw (-)Tj 0.251 Tw 0 -1.218 TD (\027\t\005 \026\027\026\035\017. \212\035\016 \022\026\032\007\024\020\024\ \023\030\036\007\017\022\021\024\030\026 \030\026\f\f\004\017\021\t\r\026\ )Tj 0 Tw (-)Tj 0.236 Tw 0 -1.218 TD (\035\017 \024\021\027\024\001\036\027\017\036 \001\026\027\f\024\r \(\210\ \231\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034\027\t\n )Tj 0.278 Tw 0 -1.218 TD (\017\027\021\036\030\r\026\035\024\n \(\212\230\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \200\026\035\034\007\026 \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf (-\027\026\004\036\027\017\036. )Tj 0.298 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC 1.076 0 Td [(\017\f\b\024\007\027\t\005 )0.6(\023\031\035 )0.5(\023\036\030\036\n\036\027\027\t\b )0.6(\007\035\016 )0.5(\n\027\024\020\024\235\026\022\021\024\030\027\024\005 )]TJ 0.764 Tw -1.076 -1.218 Td (\035\024\020\017\f\021\017\004\036\f\022\024\005 \030\036\020\030\036\f\f\ \017\017 \r\022\035\033\004\026\035\017 \023\024\022\026\026\021\036\035\ \017, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.2026 56.0378 Tm (94)Tj ET endstream endobj 1054 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 540.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 540.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 513.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 513.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 459.1763 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.007 Tw 9 0 0 9 90.7087 730.4919 Tm [(\(MD)30(A\), free h)12(y)14(dro)14(xyp)46(roline, conjug)12.1(ated dienes, ascorbic acid, lactate and sero)13(tonin, as w)12(ell as intra-abdominal p)45.9(res)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD [(sure \(IAP\), w)12(ere measured.)]TJ 0.089 Tw T* [(RESUL)30(T)-10(S: P)18(atients with C)-18(AL had signif)-43(icantly higher median lev)13(els of MD)30(A \(4,4 [3,9\2314,7] vs 3,1 [2,4\2313,6] nmol/)]TJ 0.148 Tw T* (mL; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\), free h)12(y)14(dro)14.1(xyp)46(roline \(18,0 [15,7\23119,6] vs 12,7 [11,1\23114,8] \251mol/L; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.001\) and IAP \(16,1 )Tj -0.011 Tw T* ([14,2\23117,9] vs 10.5 [8,8\23115,1] mmHg; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\) on postoperativ)13.1(e d)25.9(ays 2\2313 as com)16(pared with controls. R)19(OC analy)]TJ 0 Tw 44.743 0 Td (-)Tj -0.001 Tw -44.743 -1.111 Td [(sis show)12(ed good discr)-36.9(iminativ)13(e ability of free h)12(y)14(dro)14.1(xyp)46(roline for C)-18(AL: A)29(UC 0.83 \(95% conf)-42.9(idence inter)-41.9(v)15.9(al \(CI\) 0.72\231)]TJ 0.043 Tw T* (0.93; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\); at a cut-of)-39.9(f)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(15 \251mol/L, sensitivity w)13(as 79.1% \(95% CI 63.9\23189.9\), specif)-42.9(icity 77.3% \(95% CI )]TJ 0.016 Tw T* [(54.6\23192.2\), positiv)13(e p)46(redictiv)13(e v)16(alue \(PPV\) 87.2% \(95% CI 72.6\23195.7\) and neg)11.9(ativ)13(e p)46(redictiv)13(e v)16(alue \(NPV\) 65.4% )]TJ 0.093 Tw T* (\(95% CI 44.3\23182.8\). IAP)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(15 mmHg yielded an A)29(UC of 0.78 \(95% CI 0.65\2310.90; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.001\), sensitivity 69.8% )Tj 0.108 Tw T* [(and specif)-42.9(icity 72.7%; MD)30(A)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (4.0 nmol/mL)Tj /Span<>> BDC ( )Tj EMC [(\227 A)28.9(UC 0.80 \(95% CI 0.68\2310.91; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.001\), sensitivity 74.4% and )Tj -0.021 Tw T* [(specif)-43(icity )0.7(77.3%. )0.6(In )0.5(multiv)16.1(ar)-37(iable )0.6(logistic )0.6(reg)14(ression, )0.6(free )0.6(h)12(y)14(dro)14(xyp)46(roline )0.6(\(odds )0.6(ratio )0.6(\(OR\) )0.5(1.35; )0.6(95% )0.6(CI )0.5(1.08\2311.69; )]TJ 0.058 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.009\), IAP \(OR 1.35; 95% CI 1.10\2311.65; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.004\) and MD)30(A \(OR 2.86; 95% CI 1.25\2316.56; p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.013\) w)12(ere )]TJ 0.098 Tw T* [(identif)-42.9(ied as independent p)46(redictors of C)-18(AL. The combined )0.5(three-mark)17.1(er model show)12(ed high p)46(rognostic accuracy)12(: )]TJ 0.023 Tw T* [(A)29(UC 0.93 \(95% CI 0.84\2310.98; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\); p \(Hos)33(mer)23.1(-Lemeshow test\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.34; N)18(ag)12(elk)17(erk)17(e R\262)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.65.)Tj 0.102 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: com)16(p)46(rehensiv)13.1(e assess)33(ment of collag)12.1(enolysis mark)17.1(ers and intra-abdominal h)12(yper)-40(tension in the early )]TJ 0.023 Tw 0 -1.111 TD [(postoperativ)13.1(e per)-37(iod allows highly accurate p)46(rediction of the r)-37(isk of anastomo)13(tic leak)11(ag)12.1(e.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 565.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colonic anastomosis suture failure, p)46(rognosis, o)14(xid)26(ativ)13(e stress, o)14(xyp)46(roline, intra-abdominal p)46(ressure)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.135 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.144 Tw 6.58 0 Td [( R)-6.5(u)-22.8(z)-35.8(i)-6(b)-20.3(o)-15(y)-33.9(z)-11.3(o)-20.4(d)-9.2(a)]TJ /Span<>> BDC ( )Tj EMC [(K)-27(.R)-21.4(.)-23.5(, G)-11.2(u)-8.3(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.K)-27(.)-23.5(, G)-11.2(u)-8.4(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.8(A)-23(.)-23.5(, N)-5.6(u)-7.6(r)-42.9(z)-11.2(o)-20.4(d)-9.3(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)-22.9(.)-7.3(M)-7.1(.)-23.5(, A)-11.7(l)-16.7(i)-12.8(-)1.5(Z)-34(a)-13(d)-15.3(e)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)15(G)-11.6(. N)-14.5(e)-12.5(w a)-8.8(p)-12.3(p)-13.7(r)-15.8(o)-18.2(a)-11.1(c)-10.2(h)-15.1(e)-22.8(s t)-21.9(o)]TJ /Span<>> BDC ( )Tj EMC [(p)-13.7(r)-19.1(e)-21(d)-15.8(i)-5(c)-41.5(t)-46.2(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n)-14(i)-5(c)23( )]TJ 0.024 Tw -6.585 -1.2 Td [(a)-7.6(n)-7.8(a)-26.6(s)-29.3(t)-21.9(o)-9.2(m)-12.4(o)-15.8(t)-46.2(i)-5(c l)-23.7(e)-13(a)-11.2(k)-24.2(a)-10.8(g)-14.4(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw 9.62 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)-1.4(9)-2.8(2)9.8(\226)50.8(1)14(0)-23.4(0)6.5(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.8(2)-1.5(5)-23.5(-)55.2(1)26.9(-)-4.2(9)-2.9(2)12.1(-)55.2(1)14(0)-23.4(0)]TJ /T1_2 1 Tf 0.01 Tc 0.025 Tw -16.634 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.03 Tw 10.591 0 Td ( \206\r\016\022\240\031\235\016\031\030\020 \202\020\200\032\020\026\031\ \025 \206\r\016\022\240\031\235, \216\217\210 \253\020\030\255\022\n\024\ \n\022\235 \b\031\024\r\030\020\032\024\023\021\027\025\025\013\235 \026\ \027\030\022\006\022\025\024\n\022\235 \r\025\022\021\027\032\024\022\023\ \027\023 \022\026\027\025\022 \003\240\r \020\f\022 )Tj 0.023 Tw -10.596 -1.2 Td (\022\240\025\022 \205\022\025\031\273, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\022\025\031, 29-31, \220\r\213\020\025\240\027, 734026, \020\030\255\ \022\n\022\024\023\020\025; e-mail: dr.hero85@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.038 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.043 Tw 14.091 0 Td [( R)22(uzibo)12(yzod)26(a K)17(ahramon R)22(uzibo)12(y)42(, A)14(vicenna T)54(a)10(jik S)28(tate Medical U)22(niv)13(ersity)42.1(, Sino st., 29-31, Dushanbe, 734026, )]TJ 0.023 Tw -14.096 -1.2 Td [(T)54(a)10(jikistan; e-mail: dr)51(.hero85@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 26.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 26.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 396.0239 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.02 Tc 0.437 Tw 10 0 0 10 42.5197 371.6679 Tm [(\203\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.493 0 Td [(\f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\017\036 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b)20( )]TJ 0.202 Tw -6.493 -1.218 Td (\021\036\b\027\017\022, \027\036\f\024\f\021\024\016\021\036\035\034\027\ \024\f\021\034 \026\027\026\f\021\024\n\024\026 \(\203\202\) \024\f\021\ \026)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.559 Tw 0 -1.218 TD (\036\021\f\016 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\017\002\024\035\036\036 \026\022\021\031\026\035\034\027\t\b \023\ \030\024\002\035\036\n)20( )]TJ 0.479 Tw T* (\026\002\007\024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\ \017\017. \232\026\f\021\024\021\026 \007\026\027\027\024\020\024 \024\f\ )Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.14 Tw T* (\035\024\032\027\036\027\017\016 \r\026\030\034\017\030\031\036\021 \024\ \021 3% \007\024)Tj /Span<>> BDC ( )Tj EMC (15%, \026)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017 \027\017\022\017\b)20( )]TJ 0.027 Tw T* [(\022\024\035\024\030\036\022\021\026\035\034\027\t\b \026\027\026\f\021\024\ \n\024\026\b \n\024\032\036\021 \007\024\f\021\017\020\026\021\034 20%)20( )]TJ 0.25 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 [1,2]. \203\202 \026\f\f\024\006\017\017\030\024\r\026\ \027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \035\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.047 Tw T* (\021\026\035\034\027\024\f\021\034\033 \(\007\024 16\22622%\), \027\036\024\ \002\b\024\007\017\n\024\f\021\034\033 \023\024\r\021\024\030)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.24 Tw T* (\027\t\b \r\n\036\001\026\021\036\035\034\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n \023\024\f\021\024\016\027\ \027\024\005)20( )]TJ 0.201 Tw T* [(\f\021\024\n\t, )0.6(\004\021\024 )0.5(\f\031\013\036\f\021\r\036\027\027\024 )0.5(\f\027\017\032\026\036\021 )0.5(\022\026\004\036\f\021\r\024 )0.5(\032\017\027\017)20( )]TJ 0 Tw T* (\023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC ([3].)Tj 0 Tc 0.055 Tw T* (\200 \023\024\f\035\036\007\027\017\036 \020\024\007\t \027\026\004\017\ \021\036\035\034\027\024\036 \r\027\017\n\026\027\017\036 \031\007\036\035\ \016\036\021\f\016 )Tj 0.321 Tw T* (\030\026\027\027\017\n \035\026\002\024\030\026\021\024\030\027\t\n \023\ \030\036\007\017\022\021\024\030\026\n \203\202. \203\026\017\002\024\035\ \036\036 )Tj -0.045 Tw T* (\017\031\004\036\027\t \222-\030\036\026\022\021\017\r\027\t\005 \002\036\ \035\024\022 \(\222\217\207\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\022\026\035\034\006\017\021\024\027\017\027 )Tj 0.034 Tw T* (\(\215\025\221\), \007\035\016 \022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026\b \023\024\022\026\026\027\026 \ \007\017\026\020\027\024)Tj 0 Tw (-)Tj 0.194 Tw T* (\f\021\017\004\036\f\022\026\016 \006\036\027\027\024\f\021\034 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (3\2265-\036 \f\031\021\022\017 \023\024\f\035\036 \022\024\035\024\030\036\ \022)Tj 0 Tw (-)Tj 0.137 Tw T* [(\021\026\035\034\027\t\b \030\036\036\022\006\017\005 \(A)17(UC 0,80\2260,84; \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\ )]TJ 0.391 Tw T* (70\226100%, \f\023\036\006\017\235\017\004\027\024\f\021\034 80\22690% \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b )Tj 0.048 Tw T* (\023\024\030\024\020\026\b\) [4,5]. \221\036\n \027\036 \n\036\027\036\036\ , \220\021\017 \n\026\030\022\201\030\t \024\021\030\026\032\026\033\021\ , )Tj 0.123 Tw T* [(\023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, )0.6(\f\017\f\021\036\n\027\t\005 )0.6(\r\024\f\023\026\035\017\021\036\035\034\027\t\005 )0.5(\024\021\r\036\021 )]TJ 0.133 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \007\026\033\021 \017\027\235\024\030\n\026\006\017\017 \024)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\034\027\t\b \n\036\b\026\027\017\n\026\b)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.469 Tw T* (\024\022\f\017\007\026\021\017\r\027\024\n \f\021\030\036\f\f\036, \007\036\ \020\030\026\007\026\006\017\017 \022\024\035\035\026\020\036\027\024\r\024\ \020\024 )Tj 0.18 Tw T* (\n\026\021\030\017\022\f\026, \021\022\026\027\036\r\024\005 \020\017\023\ \024\022\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\027\024\005 \020\017)Tj 0 Tw (-)Tj 0.29 Tw T* (\023\036\030\021\036\027\017\017, \017\020\030\026\033\013\017\b \022\035\ \033\004\036\r\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\004\027\024\f\021\017 )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\026.)Tj 0.199 Tw 23.244 32.881 Td (\215\036\030\f\023\036\022\021\017\r\027\t\n \027\026\023\030\026\r\035\036\ \027\017\036\n \016\r\035\016\036\021\f\016 \023\024\017\f\022 \n\026\030\ )Tj 0 Tw (-)Tj 0.004 Tw T* [(\022\036\030\024\r, \024\021\030\026\032\026\033\013\017\b \023\026\021\024\ \020\036\027\036\021\017\004\036\f\022\017\036 )0.5(\n\036\b\026\027\017\n\t \027\036)]TJ 0 Tw (-)Tj 0.114 Tw T* (\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017: \035\024\022\026\ \035\034\027\031\033 \017\001\036\n\017\033, \024\022\f\017\007\026\021\017\ \r\027\t\005 )Tj 0.342 Tw T* (\f\021\030\036\f\f \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036 \n\036\021\026\002\024\035\017\n\026\ \f\024\036\007\017\027\017\021\036\035\034\027\024\005 )Tj 0.131 Tw T* (\021\022\026\027\017 \(\022\024\035\035\026\020\036\027\024\035\017\) [\ 6]. \025\030\024\n\036 \021\024\020\024, \r\026\032\027\031\033 \030\024\ \035\034 )Tj 0.148 Tw T* (\017\020\030\026\036\021 \f\017\027\007\030\024\n \r\027\031\021\030\017\ \002\030\033\001\027\024\005 \020\017\023\036\030\021\036\027\017\017 \(\ \200\207\206\), )Tj 0.016 Tw T* (\022\024\021\024\030\t\005 \027\026\023\030\016\n\031\033 \031\b\031\007\ \001\026\036\021 \n\017\022\030\024\006\017\030\022\031\035\016\006\017\033\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\017)Tj 0 Tw (-)Tj T* (\001\036\004\027\024\005 \f\021\036\027\022\036 [7].)Tj 0.617 Tw T* (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\t\036 \017\f\f\035\ \036\007\024\r\026\027\017\016 \007\036\n\024\027\f\021\030\017\030\031\033\ \021 )Tj 0.455 Tw T* [(\022\035\033\004\036\r\031\033 )0.6(\030\024\035\034 )0.5(\f\r\024\002\024\007\027\024-\030\026\007\017\022\026\035\034\027\t\b )0.6(\023\030\024\006\036\f\f\024\r )]TJ 0.101 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\016 \022\024\035\035\026\020\036\027\024\ \r\024\020\024 \n\026\021\030\017\022\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\017 )Tj 0.07 Tw T* [(\022\024\035\024\030\036\022\021\026\035\034\027\t\b )0.5(\026\027\026\f\021\024\n\024\024\r: \r\035\017\016\027\017\036 \020\017\ \023\024\022\f\017\017, )0.5(\020\017)]TJ 0 Tw (-)Tj 0.105 Tw T* [(\023\036\030\002\026\030\017\004\036\f\022\024\005 )0.6(\024\022\f\017\020\036\027\026\006\017\017, )0.5(\026\027\021\017\024\022\f\017\007\026\027\021\027\024\005 )0.6(\021\036\030\026)]TJ 0 Tw (-)Tj 0.133 Tw T* [(\023\017\017 \(\r\017\021\026\n\017\027 )0.5(C, N-\026\006\036\021\017\035\006\017\f\021\036\017\027, )0.5(\022\024\220\027\017\n )0.5(Q10\) \f\024)]TJ 0 Tw (-)Tj 0.022 Tw T* (\023\030\024\r\024\032\007\026\036\021\f\016 \017\n\036\027\036\027\017\ \036\n \031\030\024\r\027\036\005 \204\212\202, \f\r\024\002\024\007\027\ \024\020\024 )Tj 0 Tw T* (\024\022\f\017\023\030\024\035\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\004\027\024\f\021\017 \001\r\024\r [8].)Tj 0.197 Tw T* (\200 \220\021\024\005 \f\r\016\017 \023\030\036\007\f\021\026\r\035\016\ \036\021\f\016 \023\036\030\f\023\036\022\021\017\r\027\t\n \023\024\017\ \f\022 )Tj 0.416 Tw T* (\022\024\n\023\035\036\022\f\027\t\b \023\030\024\020\027\024\f\021\017\004\ \036\f\022\017\b \017\027\007\017\022\026\021\024\030\024\r, \024\021\030\ \026)Tj 0 Tw (-)Tj 0.185 Tw T* (\032\026\033\013\017\b \027\036 \021\024\035\034\022\024 \r\024\f\023\026\ \035\017\021\036\035\034\027\t\005 \024\021\r\036\021, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\022\026\035\034\027\t\036 \023\030\024\006\036\f\f\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\036 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \024\022\f\017\007\026\021\017\r\027\024\036 )Tj 0.444 Tw T* [(\023\024\r\030\036\032\007\036\027\017\036, )0.6(\022\024\035\035\026\020\036\027\024\035\017, )0.6(\027\026\030\031\001\036\027\017\016 )0.5(\n\024\021\024\030\017\022\017 )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\027\024\005 \020\036\n\024\007\017\ \027\026\n\017\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 115.9299 Tm [(\017\034\r\237)5( \031\032\032\r\034\230\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.747 Tw 10 0 0 10 274.9606 91.5739 Tm [(\210\006\036\027\017\021\034 )0.5(\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 )0.6(\006\036\027\027\024\f\021\034 )0.6(\002\017\024\b\017\n\017\004\036)]TJ 0 Tw (-)Tj 0.286 Tw T* (\f\022\017\b \n\026\030\022\036\030\024\r \024\022\f\017\007\026\021\017\ \r\027\024\020\024 \f\021\030\036\f\f\026, \007\036\020\030\026\007\026\006\ \017\017 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (93)Tj ET endstream endobj 1051 0 obj [1057 0 R] endobj 1052 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 292.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 292.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 255.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 255.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-92-100)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 79.1962 695.3259 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022)-23.3(\224\005\025\013\t\025)21.1(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-9.9(\026)11(\025\213\026)11(\004\020\200\t\025\016)-10(\026\n )]TJ 5.352 -1.105 Td [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10.1(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 649.822 Tm [(\033)-21(\002)31(\212\n\255\025\221\212\025\202\017\022)-23.2(\037.\033)124(., \031)70(\002\020\025\b\022)-23.3(\235.\037., \031)70(\002\020\025\b\022)-23.3(\f)-31(.\f)-31(., \007\002\005)31(\212\025\202\017\022)-23.3(\203.\235., \f)-20.9(\020\n-\203\017\202\004\022)-23.3(\001.\031)72(.)]TJ 10 0 0 10 70.8661 632.1527 Tm [(\031)41(\036)20(\227 \253\032)40(\017\202\226\n\r\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-10(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026 \n\024\004\t\n \f\255\002 \017\020\n \n\255\t\n \001\n\t\025\273\ \(\002\020.\022)-23.2(\001\n\t\025, )]TJ 0 -1.2 TD [(\202.\022)-23.3(2)47(9-3)138(1)69(, \013)62(.\022)-23.2(\201\002\204\017\t\255\004, 7)57(3)58(402)46(6, \032)40(\017\202\226\n\r\n\016)-9.9(\026)11(\017\t\))]TJ /T1_0 1 Tf 0.278 Tw 9 0 0 9 119.0551 601.6488 Tm [(\037\036\035\034: )0.5(\031\006\027\025\022\023\017 )0.6(\033\032\031\b\025\031\024\023\022\007\027\024\n\r\005 )0.5(\016\025\020\007\022\026\031\024\023\017 )0.6(\026\020\032\n\027\032\031\021 )0.5(\031\n\024\022\030\020\023\022\021\025\031\b\031 )0.5(\024\023\032\027\024\024\020, )0.5(\030\027\b\032\020\030\020\006\022\022 )0.5(\n\031\f\f\020\b\027\025\020 )]TJ 0.023 Tw 0 -1.111 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\021\025\r\023\032\022\240\032\005\213\025\031\235 \b\022\033\027\032\023\ \027\025\016\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\022 \025\027\024\031\024\023\031\t\023\027\f\ \017\025\031\024\023\022 \023\031\f\024\023\031\n\022\213\027\007\025\031\ \b\031 \020\025\020\024\023\031\026\031\016\020 \(\001\003\).)Tj 0.002 Tc 0.139 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \033\032\031\021\027\030\027\025\031 \032\027\023\ \032\031\024\033\027\n\023\022\021\025\031\027 \022\024\024\f\027\030\031\ \021\020\025\022\027 \033\031)Tj /Span<>> BDC ( )Tj EMC (\023\022\033\r \253\024\f\r\007\020\235-\n\031\025\023\032\031\f\017\273\ . \211)Tj /Span<>> BDC ( )Tj EMC [(\020\025\020\f\022\016)2( )]TJ 0.154 Tw T* (\021\n\f\005\007\027\025\031 65 \033\020\006\022\027\025\023\031\021 \033\ \031\024\f\027 \032\027\016\027\n\006\022\022 \023\031\f\024\023\031\235\ \n\022\213\n\022: \031\024\025\031\021\025\020\t \b\032\r\033\033\020 \(\ n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\020\006\022\027\025\023\013 \024)Tj /Span<>> BDC ( )Tj EMC (\032\020\016)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.094 Tw T* (\021\022\021\213\027\235\024\t \001\003, \b\032\r\033\033\020 \024\032\020\ \021\025\027\025\022\t \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (22\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\020\006\022\027\025\023\013 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\024\f\031\255\025\027\025\025\013\026 \023\027\007\027\025\022\ \027\026. \001\020)Tj /Span<>> BDC ( )Tj EMC [(2\2313-\022 \024\r\023\n\022 \033\031\024\f\027)2( )]TJ 0.079 Tw 0 -1.111 TD [(\031\033\027\032\020\006\022\022 \031\006\027\025\022\021\020\f\022 \r\032\ \031\021\025\022 \026\020\f\031\025\031\021\031\b\031 \030\022\020\f\017\ \030\027\b\022\030\020 \(\215\220\003\), \024\021\031\240\031\030\025\031\ \b\031 \031\n\024\022\033\032\031\f\022\025\020, \f\020\n\023\020\023\020\ , \030\022\027\025\031\021\013\200)2( )]TJ 0.054 Tw 0 -1.111 TD (\n\031\025\236\005\b\020\023\031\021, \020\024\n\031\032\240\022\025\031\ \021\031\235 \n\022\024\f\031\023\013, \f\020\n\023\020\023\020, \024\027\ \032\031\023\031\025\022\025\020, \020)Tj /Span<>> BDC ( )Tj EMC [(\023\020\n\255\027 \021\027\f\022\007\022\025\r \021\025\r\023\032\022\240\ \032\005\213\025\031\b\031 \030\020\021\f\027\025\022\t)2( )]TJ -0.002 Tw T* (\(\211\221\220\).)Tj 0 Tc 0.237 Tw T* (\206\036\207\210\035\034\003\201: \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\001\003 \026\027\030\022\020\025\025\013\027 \r\032\031\021\025\022 \215\ \220\003 \(4,4 [3,9\2314,7] \033\032\031\023\022\021 3,1 [2,4\2313,6] \025\ \026\031\f\017/\026\f; )Tj 0.091 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC 0.801 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.823 0 Td [(0,001\), )0.6(\024\021\031\240\031\030\025\031\b\031 )0.6(\031\n\024\022\033\032\031\f\022\025\020 )0.7(\(18,0 )0.5([15,7\23119,6] )0.6(\033\032\031\023\022\021 )0.6(12,7 )0.5([11,1\23114,8] )0.6(\026\n\026\031\f\017/\f; )0.6(p)]TJ /Span<>> BDC ( )Tj EMC 37.164 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.823 0 Td [(0,001\) )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 3.777 0 Td (\211\221\220 )Tj 0.069 Tw -43.389 -1.111 Td (\(16,1 [14,2\23117,9] \033\032\031\023\022\021 10,5 [8,8\23115,1] \026\026\ \032\023. \024\023.; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \025\020)Tj /Span<>> BDC ( )Tj EMC (2\2313-\022 \024\r\023\n\022 \033\031\024\f\027 \031\033\027\032\020\006\ \022\022 \240\013\f\022 \024\023\020)Tj 0 Tw (-)Tj 0.053 Tw 0 -1.111 TD (\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\026\031 \021\ \013\213\027, \007\027\026 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \240\027\016 \025\027\024\031\024\023\031\t\023\027\ \f\017\025\031\024\023\022 \020\025\020\024\023\031\026\031\016\020. \004\ \032\022)Tj /Span<>> BDC ( )Tj EMC (ROC-\020\025\020\f\022\016\027 \024\021\031\240\031\030\025\013\235 )Tj 0.16 Tw 0 -1.111 TD [(\031\n\024\022\033\032\031\f\022\025 )0.5(\030\027\026\031\025\024\023\032\022\032\031\021\020\f )0.5(\200\031\032\031\213\r\005 )0.5(\030\022\024\n\032\022\026\022\025\022\032\r\005\212\r\005 )0.5(\024\033\031\024\031\240\025\031\024\023\017 \021)]TJ /Span<>> BDC ( )Tj EMC (\031\023\025\031\213\027\025\022\022 \001\003: AUC 0,83 \(95% )Tj 0.029 Tw T* [(\030\031\021\027\032\022\023\027\f\017\025\013\235 )0.6(\022\025\023\027\032\021\020\f )0.5(\(\220\002\) )0.5(0,72\2310,93; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 18.706 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.762 0 Td [(0,001\); )0.5(\033\032\022)]TJ /Span<>> BDC ( )Tj EMC 4.927 0 Td [(\033\031\032\031\b\031\021\031\026 )0.5(\016\025\020\007\027\025\022\022)]TJ /Span<>> BDC ( )Tj EMC 8.64 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC 0.762 0 Td [(15 )0.5(\026\n\026\031\f\017/\f )0.5(\007\r\021\024\023\021\022\023\027\f\017)]TJ 0 Tw (-)Tj 0.164 Tw -33.796 -1.111 Td [(\025\031\024\023\017 )0.5(\024\031\024\023\020\021\022\f\020 )0.6(79,1%, )0.6(\024\033\027\006\022\203\022\007\025\031\024\023\017)]TJ /Span<>> BDC ( )Tj EMC 17.665 0 Td [(\227 )0.5(77,3%, )0.5(\033\031\f\031\255\022\023\027\f\017\025\020\t )0.6(\033\032\031\b\025\031\024\023\022\007\027\024\n\020\t )0.5(\006\027\025\025\031\024\023\017 )0.5(\(\004\004\037\))]TJ /Span<>> BDC ( )Tj EMC 26.375 0 Td (\227 )Tj -0.003 Tw -44.039 -1.111 Td (87,2%, \031\023\032\022\006\020\023\027\f\017\025\020\t \033\032\031\b\025\ \031\024\023\022\007\027\024\n\020\t \006\027\025\025\031\024\023\017 \(\ \217\004\037\))Tj /Span<>> BDC ( )Tj EMC (\227 65,4%. \211\221\220)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (15 \026\026 \032\023. \024\023. \200\020\032\020\n\023\027\032\022\016\031\ \021\020\f\031\024\017 )Tj 0.122 Tw T* [(AUC )0.5(0,78 )0.5(\(95% )0.5(\220\002 )0.5(0,65\2310,90; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 13.475 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.855 0 Td [(0,001\), )0.5(\007\r\021\024\023\021\022\023\027\f\017\025\031\024\023\017\005 )0.6(69,8% )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 15.913 0 Td [(\024\033\027\006\022\203\022\007\025\031\024\023\017\005 )0.5(72,7%; )0.5(\215\220\003)]TJ /Span<>> BDC ( )Tj EMC 12.738 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC 0.855 0 Td (4,0 )Tj 0.186 Tw -43.835 -1.111 Td (\025\026\031\f\017/\026\f)Tj /Span<>> BDC ( )Tj EMC (\227 AUC 0,80 \(95% \220\002 0,68\2310,91; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \007\r\021\024\023\021\022\023\027\f\017\025\031\024\023\017 74\ ,4%, \024\033\027\006\022\203\022\007\025\031\024\023\017 77,3%. )Tj 0.083 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\b\031\203\020\n\023\031\032\025\031\235 \f\031\b\022\024\023\ \022\007\027\024\n\031\235 \026\031\030\027\f\022 \025\027\016\020\021\022\ \024\022\026\013\026\022 \033\032\027\030\022\n\023\031\032\020\026\022 \ \001\003 \031\n\020\016\020\f\022\024\017 \024\021\031\240\031\030\025\013\ \235 \031\n\024\022\033\032\031)Tj 0 Tw (-)Tj -0.027 Tw T* [(\f\022\025 )0.5(\(\031\023\025\031\213\027\025\022\027 )0.5(\213\020\025\024\031\021 )0.5(\(\217\237\) )0.5(1,35; 95% )0.5(\220\002 1,08\2311,69; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 24.154 0 Td [(0,009\), )0.5(\211\221\220 \(\217\237 )0.5(1,35; 95% \220\002 )0.5(1,10\2311,65; p)]TJ /Span<>> BDC ( )Tj EMC 17.548 0 Td (=)Tj /Span<>> BDC ( )Tj EMC (0,004\) )Tj 0.036 Tw -41.703 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC 0.767 0 Td [(\215\220\003 )0.6(\(\217\237 )0.5(2,86; )0.6(95% )0.5(\220\002 )0.6(1,25\2316,56; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 15.074 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.768 0 Td [(0,013\). )0.6(\002\025\023\027\b\032\020\f\017\025\020\t )0.6(\026\031\030\027\f\017, )0.5(\031\240\236\027\030\022\025\t\005\212\020\t )0.5(\023\032\022 )0.6(\033\031\n\020\016\020\023\027\f\t, )0.5(\033\032\031)]TJ 0 Tw (-)Tj 0.101 Tw -16.61 -1.111 Td (\030\027\026\031\025\024\023\032\022\032\031\021\020\f\020 \021\013\024\031\ \n\r\005 \033\032\031\b\025\031\024\023\022\007\027\024\n\r\005 \023\031\ \007\025\031\024\023\017: AUC 0,93 \(95% \220\002 0,84\2310,98; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\); \032)Tj /Span<>> BDC ( )Tj EMC (\(\023\027\024\023 )Tj 0.023 Tw T* (\225\031\024\026\027\032\020\231\035\027\026\027\213\031\r\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34; \033\024\027\021\030\031-R\262 \001\020\235\030\255\027\f\n\027\032\ \n\020)Tj /Span<>> BDC ( )Tj EMC (\227 0,65.)Tj 0.197 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.6(\n\031\026\033\f\027\n\024\025\020\t )0.6(\031\006\027\025\n\020 )0.5(\026\020\032\n\027\032\031\021 )0.6(\n\031\f\f\020\b\027\025\031\f\022\016\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 27 0 Td [(\021\025\r\023\032\022\240\032\005\213\025\031\235 )0.5(\b\022\033\027\032\023\027\025\016\022\022 )0.5(\(\024\021\031\240\031\030\025\013\235 )]TJ -0.017 Tw -27 -1.111 Td [(\031\n\024\022\033\032\031\f\022\025, )0.5(\215\220\003 \022)]TJ /Span<>> BDC ( )Tj EMC 7.895 0 Td [(\211\221\220\), )0.5(\021\013\033\031\f\025\027\025\025\020\t )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC [(2\2313-\022 )0.5(\024\r\023\n\022 \033\031\024\f\027 )0.5(\031\033\027\032\020\006\022\022, \033\031\016\021\031\f\t\027\023 \024)]TJ /Span<>> BDC ( )Tj EMC 26.699 0 Td [(\021\013\024\031\n\031\235 )0.5(\023\031\007\025\031\024\023\017\005 \033\032\031)]TJ 0 Tw (-)Tj 0.033 Tw -34.593 -1.111 Td (\b\025\031\016\022\032\031\021\020\023\017 \032\022\024\n \001\003 \022)Tj /Span<>> BDC ( )Tj EMC (\021\013\030\027\f\t\023\017 \033\020\006\022\027\025\023\031\021 \b\032\ \r\033\033\013 \021\013\024\031\n\031\b\031 \032\022\024\n\020 \030\f\t \ \240\031\f\027\027 \022\025\023\027\025\024\022\021\025\031\b\031 \026\031\ \025\022\023\031\032\022\025\b\020 )Tj 0.023 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\032\020\025\025\027\235 \n\031\032\032\027\n\006\022\022 \023\027\032\020\ \033\022\022.)Tj /T1_2 1 Tf 0.01 Tc 0.009 Tw 8 0 0 8 70.9061 326.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.014 Tw 8.484 0 Td ( \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\017 \023\031\ \f\024\023\031\n\022\213\027\007\025\031\b\031 \020\025\020\024\023\031\026\ \031\016\020, \033\032\031\b\025\031\016\022\032\031\021\020\025\022\027\ , \031\n\024\022\030\020\023\022\021\025\013\235 \024\023\032\027\024\024\ , \031\n\024\022\033\032\031\f\022\025, \021\025\r\023\032\022)Tj 0 Tw (-)Tj 0.023 Tw -8.489 -1.2 Td (\240\032\005\213\025\031\027 \030\020\021\f\027\025\022\027)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.028 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.018 Tc -0.035 Tw 9.048 0 Td ( \217\031\017\002\024\005\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\025.\217., \206\031\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\025., \206\031\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \203\031\030\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\003.\204., \202\035\017-\003\026\007\036)Tj /Span<>> BDC ( )Tj EMC (\222.\206. \203\024\r\t\036 \023\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\033 \027\036\f\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc -0.035 Tw -9.053 -1.2 Td (\f\021\024\016\021\036\035\034\027\024\f\021\017 \021\024\035\f\021\024\022\ \017\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026. )Tj /T1_0 1 Tf -0.008 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.035 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (92\226100. https://doi.org/10.33878/2073-7556-2026-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (25-1-92-100)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 188.6772 229.0332 Tm [(Ne)11(w appr)20(oach)11(es to\022)-23.3(pr)31(ediction )]TJ 0 Tw ( )Tj 0.023 Tw -0.151 -1.167 Td [(of\022)-23.3(colonic\022)-23.2(anastomotic leakage)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 183.5292 Tm [(K)41(ahr)21(amon\022)-23.3(R.\022)-23.2(Ru)21(ziboy)21(z)10(oda, Mahmadsh)11(oh\022)-23.2(K.\022)-23.3(Gulov)21(, Afz)15.1(alsh)11(o\022)-23.3(A)-31(.\022)-23.3(Gulov)21.1(, )]TJ 0 -1.143 TD [(Z)21(oir)20(sh)11(o\022)-23.2(M.\022)-23.3(Nur)20(z)10(oda, Sukhr)20.1(ob\022)-23.3(G.\022)-23.3(Ali-Z)21.1(ade)]TJ 10 0 0 10 70.8661 149.86 Tm [(A)20(vicenna T)40(ajik State Medical Univ)12.1(er)20(sit)-20(y \(Sino\022)-23.2(st., 2)47(9-3)138(1)69(, Dushanbe, 7)57(3)58(402)46(6, T)40(ajikistan\))]TJ /T1_0 1 Tf 0.029 Tw 9 0 0 9 119.0551 131.356 Tm [(\003IM: to assess the p)46(rognostic signif)-43(icance of mark)17(ers of o)14(xid)26(ativ)13(e stress, collag)12(en deg)14(rad)26(ation and intra-abdominal )]TJ 0.023 Tw 0 -1.111 TD [(h)12(yper)-40(tension in the dev)13(elopment of colorectal anastomo)13.1(tic leak)11.1(ag)12(e.)]TJ -0.029 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: retrospectiv)13.1(e case-control study w)13(as conducted including 65 patients af)-45.9(ter colorectal resec)]TJ 0 Tw (-)Tj 0.053 Tw T* [(tion: the study g)14(roup \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(43\) com)16(p)46(r)-36.9(ised patients who dev)13(eloped anastomo)13.1(tic leak)11(ag)12(e, and the com)16(par)-37(ison g)14(roup )]TJ -0.03 Tw T* (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(22\) included patients with an unev)13(entful postoperativ)13.1(e course. The g)14(roups w)12(ere com)16(parable in ter)-14(ms of ag)12(e, se)-15(x, )]TJ -0.024 Tw 0 -1.111 TD [(operativ)13(e time and intraoperativ)13.1(e blood loss \(p)]TJ /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(0.05\). On postoperativ)13.1(e d)26(ays 2\2313, serum lev)13(els of malondialdeh)12(y)14(de )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 610.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 601.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 139.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 130.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.115 56.0378 Tm (92)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 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\200\035\026\007\ \017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.307 Tw 0 -1.218 TD (\024\027\022\024\035\024\020 \024\021\007\036\035\036\027\017\016 \026\002\ \007\024\n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\017\ \017 \2232, )Tj 0.14 Tw T* (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; ORCID )Tj 0 Tw T* (0000-0003-2429-0834)Tj 0.739 Tw T* (\231\017\030\026\035\017\036\r \217\031\f\035\026\027 \204\026\020\024\n\ \036\021-\202\n\017\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.307 Tw T* (\024\027\022\024\035\024\020 \024\021\007\036\035\036\027\017\016 \026\002\ \007\024\n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\017\ \017 \2232, )Tj 0.14 Tw T* (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; ORCID )Tj 0 Tw T* (0000-0002-7346-4610)Tj 0.155 Tw 23.244 24.356 Td (\216\026\035\026\235\016\027 \202\035\036\022\f\026\027 \202\035\034\002\ \036\030\021\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\021.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tw (-)Tj 0.154 Tw T* [(\235\036\007\030\t )0.5(\026\027\026\035\017\026 )0.6(\007\026\027\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.17 0 Td [(\017\f\022\031\f\f\021\r\036\027\027\024\020\024 )0.6(\017\027\021\036\035\035\036\022)]TJ 0 Tw (-)Tj 0.324 Tw -11.17 -1.218 Td (\021\026 \205\215\204, \025\031\002\026\027\f\022\017\005 \020\024\f\031\ \007\026\030\f\021\r\036\027\027\t\005 \031\027\017\r\036\030\f\017\021\036\ \021; )Tj 0 Tw T* (ORCID 0000-0003-2324-3649 SPIN-\022\024\007: 3917\2266210)Tj 0.24 Tw T* (\025\026\031\001\026\027\f\022\017\005 \200\026\035\036\030\017\005 \207\ \024\030\017\f\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031)Tj 0 Tw (-)Tj 0.398 Tw T* (\033\013\017\005 \024\021\007\036\035\036\027\017\036\n \026\002\007\024\ \n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\017\017 \ \2232, )Tj 0.423 Tw 0 -1.218 TD (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; \007\024)Tj 0 Tw (-)Tj 0.268 Tw 0 -1.218 TD (\006\036\027\021 \022\026\235\036\007\030\t \b\017\030\031\030\020\017\004\ \036\f\022\017\b \002\024\035\036\027\036\005, \025\031\002\026\027\f\022\ \017\005 )Tj 0.291 Tw T* (\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021; ORCID )Tj 0 Tw T* (0000-0001-7839-6410)Tj 0.426 Tw T* (\213\030\n\026\022\024\r \213\r\020\036\027\017\005 \202\035\036\022\f\036\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\n\036\f\021\017)Tj 0 Tw (-)Tj 0.509 Tw T* (\021\036\035\034 \020\035\026\r\027\024\020\024 \r\030\026\004\026 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017,\ )Tj 0.14 Tw 0 -1.218 TD (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; ORCID )Tj 0 Tw 0 -1.218 TD (0009-0003-7280-2360; SPIN-\022\024\007: 7388-9323)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(V)25(adim V. P)10.1(ol)30(ov)-16(ink)-16(in)]TJ /Span<>> BDC ( )Tj EMC (\227)Tj 5.83 0 0 5.83 395.1256 533.3118 Tm ( )Tj 10 0 0 10 396.4839 529.9818 Tm (0000-0003-3649-1027)Tj -9.318 -1.218 Td [(Nikol)-16(a)15.1(y V. Dor)-32(onin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2429-0834)Tj T* [(Rusl)-15.9(an M-A. S)-16(hir)-32.9(al)-31(iyev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7346-4610)Tj T* [(Ale)-17.9(x)-11(an A. Khal)-15.9(af)-34(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2324-3649)Tj T* [(V)25(aler)-37(iy B. K)-15.9(aushansk)-15.9(iy)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7839-6410)Tj T* [(Ev)-21(geniy A. Er)-15.8(makov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0003-7280-2360)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 432.5579 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.174 Tw 8 0 0 8 70.8661 419.7232 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Miles)Tj /Span<>> BDC ( )Tj EMC 2.467 0 Td [(WE. )0.6(A)]TJ /Span<>> BDC ( )Tj EMC 2.85 0 Td [(me)-12(t)-13(hod )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.712 0 Td [(per)-24(for)-15.9(ming )0.5(abd)-16(omino-per)-36.9(ineal )0.6(e)-18(x)-13(c)-24(ision )]TJ -0.008 Tw -11.325 -1.25 Td [(for car)-31.9(c)-24(inoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he r)-24(ec)-16(tum and of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ter)-16(minal por)-22(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he pel)30(v)-16(ic )]TJ 0.098 Tw 0 -1.25 TD [(col)30(on \(1908\). )]TJ /T1_1 1 Tf [(C)-18(A Cancer J Clin)]TJ /T1_0 1 Tf [(. 1971;21\(6\):361\226364. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3322/)Tj T* [(canjcl)-31(in.21.6.361)]TJ 0 0 0 1 k /GS1 gs 0.203 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Holm)Tj /Span<>> BDC ( )Tj EMC (T, Ljung)Tj /Span<>> BDC ( )Tj EMC [(A, H\344ggmar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(T, Jur)-24(ell)]TJ /Span<>> BDC ( )Tj EMC [(G, L)-32(a)-17(ger)-31.9(gr)-24(en)]TJ /Span<>> BDC ( )Tj EMC [(J. E)35(xtended )]TJ 0.103 Tw -1.296 -1.25 Td [(abd)-16(ominoper)-36.9(ineal r)-23.9(esec)-16(t)-32(ion )0.5(wi)-24(t)-13(h )0.5(gl)35(uteus )0.5(maximus )0.5(fl)-16(ap )0.5(r)-24(econstr)-21.9(uc)]TJ 0 Tw (-)Tj 0.033 Tw T* [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he pel)30(v)-15.9(ic fl)30.1(o)-16(or for r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_1 1 Tf (Br J Surg)Tj /T1_0 1 Tf (. 2007;94\(2\):232\226)Tj 0.023 Tw T* [(238. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.5489)Tj 0 0 0 1 k /GS1 gs 0.117 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC (X, Sun)Tj /Span<>> BDC ( )Tj EMC (T, Xie)Tj /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)15(t)17(or abd)-16(ominoper)-37(ineal e)-17.9(x)-13(c)-24(i)]TJ 0 Tw (-)Tj 0.184 Tw -1.296 -1.25 Td [(sion for )0.5(l)30(o)-14(w r)-23.9(ec)-16(t)15(al cancer: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and )0.5(me)-12(t)15(a-anal)35(y)-13(sis )]TJ 0.321 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he shor)-22(t-ter)-15.9(m outcome. )]TJ /T1_1 1 Tf (Colorectal Dis.)Tj /T1_0 1 Tf ( 2015;17\(6\):474\226481. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.12921)Tj 0 0 0 1 k /GS1 gs 0.057 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Muster)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(GD, Kl)-15.9(aver)]TJ /Span<>> BDC ( )Tj EMC [(CEL, Bosk)10(er)]TJ /Span<>> BDC ( )Tj EMC [(RJI, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biol)30.1(o)-16(gical Mesh Cl)30(osur)-23.9(e )]TJ 0.179 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he P)30(el)30.1(v)-16(ic Fl)30(o)-16(or Af)-28(ter )0.5(E)35(xtr)-33(alev)-15(a)15(t)17.1(or A)-14(bd)-16(ominoper)-37(ineal )0.5(R)13(esec)-16(t)-32(ion )]TJ 0.181 Tw T* [(for R)13(ec)-16(t)15(al Cancer: A)]TJ /Span<>> BDC ( )Tj EMC [(Mul)56.1(t)-32(icenter R)-10(and)-16(omized Contr)-32(olled T)50(r)-37(ial \(t)-13(he )]TJ 0 Tw T* [(BIOPEX-stud)17.1(y\). )]TJ /T1_1 1 Tf 0.241 Tw 6.63 0 Td (Ann Surg)Tj /T1_0 1 Tf [(. 2017;265\(6\):1074\2261081. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -6.63 -1.25 Td [(SL)-35(A.0000000000002020)]TJ 0 0 0 1 k /GS1 gs 0.289 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bl)30(ok)]TJ /Span<>> BDC ( )Tj EMC (RD, de Jonge)Tj /Span<>> BDC ( )Tj EMC [(J, de K)25(oning)]TJ /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(opensi)-23.9(t)-10(y S)-24(cor)-24(e )]TJ 0.172 Tw -1.296 -1.25 Td [(A)15(d)17(justed Com)10(p)32(ar)-36.9(ison of)]TJ /Span<>> BDC ( )Tj EMC [(P)30(el)30(v)-15.9(iper)-37(ineal M)-24(or)-23.9(bidi)-24(t)-10(y W)-16(i)-24(t)-12.9(h and W)-16(i)-24(t)-12.9(hout )]TJ 0.301 Tw T* [(Oment)17(opl)-16(ast)-9.9(y F)10(oll)30.1(o)-14(wing A)-13.9(bd)-16(ominoper)-37(ineal R)13(esec)-16(t)-32(ion for P)35(r)-37(imar)-23.9(y )]TJ 0.002 Tw T* [(R)13(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf [( 2019;62\(8\):952\226959. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (DCR.0000000000001349)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.356 Tw T* [(6)0.5(.)]TJ /Span<>> BDC 0.815 0 Td ( )Tj EMC 0.51 0 Td [(A)-24.5(g)0.5(g)0.5(a)0.5(r)-37.6(w)-11.5(a)0.5(l)]TJ /Span<>> BDC 3.835 0 Td ( )Tj EMC [(N)0.5(,)0.5( S)0.5(e)0.5(sh)0.5(a)0.5(d)0.5(r)-36.5(i)]TJ /Span<>> BDC 5.499 0 Td ( )Tj EMC [(R)0.5(A)0.5(,)0.5( A)0.5(r)-31.5(v)-15.5(i)0.5(nd)]TJ /Span<>> BDC 5.208 0 Td ( )Tj EMC [(A)0.5(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 2.806 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( P)30.5(e)0.5(r)-36.5(i)0.5(ne)0.5(a)0.5(l)0.5( W)20.5(o)0.5(u)0.5(nd)10( )]TJ 0 Tc 0.32 Tw -18.673 -1.25 Td [(Com)10(pl)-31(ica)15(t)-31.9(ions F)10(oll)30.1(o)-14(wing E)35(xtr)-32.9(alev)-15(a)15(t)17(or )0.5(A)-14(bd)-16(ominoper)-36.9(ineal )0.5(E)35(x)-13(c)-24(ision: )]TJ 0.008 Tc 0.35 Tw T* [(E)34.9(xper)-37(ience )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.475 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 1.062 0 Td [(R)13(egional )0.5(Cancer )0.5(Center. )]TJ /T1_1 1 Tf 10.992 0 Td [(Indian )0.5(J Surg Oncol.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 9.109 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2018;9\(2\):211\226214. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s13193-018-0741-y)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw T* [(7)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.301 0 Td [(W)22.5(es)0.5(t)]TJ /Span<>> BDC 1.896 0 Td ( )Tj EMC [(N)0.5(P)0.5(, A)0.5(n)0.5(de)0.5(r)-36.5(i)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(C)0.5(,)0.5( Sm)0.5(i)-23.5(t)-12.5(h)]TJ /Span<>> BDC 9.86 0 Td ( )Tj EMC [(K)20.5(J,)0.5( e)-11.5(t)]TJ /Span<>> BDC 3.141 0 Td ( )Tj EMC [(a)0.5(l)0.5(. E)0.5(u)0.5(r)-31.6(o)0.5(p)0.5(e)0.5(an)0.5( E)35.5(xt)0.5(r)-32.5(a)0.5(l)0.5(ev)-14.5(a)15.5(t)17.4(o)0.5(r)2( )]TJ 0 Tc 0.35 Tw -16.197 -1.25 Td [(A)-14.1(bd)-16.1(ominoper)-37.1(ineal )0.5(E)34.9(x)-13.1(c)-24.1(ision S)14.9(tud)16.9(y )0.5(G)19.9(r)-32.1(oup. )0.5(Mul)55.9(t)-32.1(icentr)-24(e e)-18(xper)-37.1(ience )]TJ 0.126 Tw T* [(wi)-24(t)-13(h e)-18(xtr)-32.9(alev)-15(a)15(t)17(or abd)-16(ominoper)-36.9(ineal e)-18(x)-13(c)-24(ision for l)30.1(o)-14(w r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_1 1 Tf 0.023 Tw T* (Br J Surg)Tj /T1_0 1 Tf [(. 2010;97\(4\):588\226599. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.6916)Tj 0 0 0 1 k /GS1 gs -0.015 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(De Nar)-24(di)]TJ /Span<>> BDC ( )Tj EMC (P, Summo)Tj /Span<>> BDC ( )Tj EMC [(V, V)-15(ignal)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Cap)25(r)-24(e)-12(t)-30(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(G. S)15(t)15(and)42(ar)-24(d ver)-10(sus e)-18(xtr)-32.9(al)]TJ 0 Tw (-)Tj 0.002 Tw -1.296 -1.25 Td [(ev)-15(a)15(t)17(or abd)-16(ominoper)-36.9(ineal l)30(o)-14(w r)-23.9(ec)-16(t)15(al cancer e)-18(x)-12.9(c)-24(ision outcomes: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(s)]TJ 0 Tw (-)Tj -0.027 Tw T* [(tema)15(t)-32(ic r)-23.9(ev)-16(iew and me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_1 1 Tf (Ann Surg Oncol)Tj /T1_0 1 Tf (. 2015;22\(9\):2997\226)Tj 0.023 Tw T* [(3006. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1245/s10434-015-4368-8)Tj 0 0 0 1 k /GS1 gs 0.02 Tc 0.708 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.355 0 Td [(\204\031)0.5(\030\026\001\022)0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\217)0.5(.\202.)0.5(, \211)0.5(\r\026\030\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\230)0.5(.\207.)0.5(, \213)0.5(\030\n\026\022)0.5(\024\r)]TJ /Span<>> BDC ( )Tj EMC [(\213.\202)0.5(., \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r)0.5(\021.)20( )]TJ 0 Tc 0.35 Tw 27.7 42.5 Td (\233\022\f\021\030\026\035\036\r\026\021\024\030\027\026\016 \002\030\033\ \001\027\024-\023\030\024\n\036\032\027\024\f\021\027\026\016 \220\022\f\ \021\017\030\023\026\006\017\016 \023\030\016\n\024\005 )Tj -0.043 Tw T* (\022\017\001\022\017: \027\036\023\024\f\030\036\007\f\021\r\036\027\027\ \t\036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\024\005 )Tj 0 Tw T* (\021\036\b\027\017\022\024\005. )Tj /T1_1 1 Tf 4.325 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf -0.003 Tw [(. 2017;\(4\):34\22639. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -4.325 -1.25 Td (7556-2017-0-4-34-39)Tj 0 0 0 1 k /GS1 gs 0.198 Tw [( / Mur)-32.9(ashko)]TJ /Span<>> BDC ( )Tj EMC [(R.A., Uv)-15(ar)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(I.B., Er)-16(makov)]TJ /Span<>> BDC ( )Tj EMC (E.A., )Tj 0.04 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)15(t)17(or A)-14(bd)-16(ominoper)-36.9(ineal E)35(x)-13(c)-24(ision of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he R)13(ec)-16(tum: S)-16(hor)-22(t-)]TJ 0.255 Tw T* [(T)40(er)-16(m Outcomes in Com)10(p)32(ar)-37(ison wi)-23.9(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Convent)-31.9(ional T)40(echnique. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.239 Tw [(. 2017;\(4\):34\22639. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2017-0-4-34-39)Tj 0 0 0 1 k /GS1 gs 0.024 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (He)Tj /Span<>> BDC ( )Tj EMC [(Z, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(XY, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(X)16(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he cl)-30.9(inical ef)-56(f)-28(ica)-17(cy )]TJ 0.014 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.062 0 Td [(l)-16(ap)32(ar)-32(oscopic )0.5(e)-18(xtr)-32.9(alev)-15(a)15(t)17(or )0.5(abd)-16(ominoper)-36.9(ineal )0.5(e)-18(x)-13(c)-24(ision )0.5(\(EL)-34.9(APE\) )0.5(and )]TJ -0.005 Tw -1.062 -1.25 Td [(non-EL)-34.9(APE for l)30(o)-14(w r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf [(U)21(pd)26(ates Surg.)]TJ /T1_0 1 Tf ( 2023;75\(3\):611\226617. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s13304-023-01466-y)Tj 0 0 0 1 k /GS1 gs 0.207 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)35(u)]TJ /Span<>> BDC ( )Tj EMC [(HC, P)30(eng)]TJ /Span<>> BDC ( )Tj EMC (H, He)Tj /Span<>> BDC ( )Tj EMC [(X)-19.9(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(shor)-21.9(t- and l)30(ong-)]TJ 0.252 Tw -1.796 -1.25 Td [(ter)-16(m outcomes af)-28(ter e)-18(xtr)-32.9(alev)-15(a)15(t)17(or abd)-16(ominoper)-36.9(ineal e)-18(x)-12.9(c)-24(ision and )]TJ 0.099 Tw T* [(st)15(and)42(ar)-24(d abd)-16(ominoper)-36.9(ineal e)-18(x)-13(c)-23.9(ision for r)-24(ec)-16(t)15(al cancer: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic )]TJ 0.058 Tw T* [(r)-24(ev)-15.9(iew and me)-12(t)15(a-anal)35(y)-13(sis)]TJ /T1_1 1 Tf (. Int J Colorectal Dis.)Tj /T1_0 1 Tf ( 2014;29\(2\):183\226191. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-013-1793-7)Tj 0 0 0 1 k /GS1 gs 0.078 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Qi)Tj /Span<>> BDC ( )Tj EMC (XY, Cui)Tj /Span<>> BDC ( )Tj EMC [(M, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(MX, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)15(t)17(or abd)-16(ominoper)-37(ineal e)-17.9(x)-13(c)-24(i)]TJ 0 Tw (-)Tj 0.009 Tw -1.796 -1.25 Td [(sion ver)-9.9(sus abd)-16(ominoper)-36.9(ineal e)-18(x)-12.9(c)-24(ision for )0.5(l)30(o)-14(w r)-23.9(ec)-16(t)15(al cancer: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(me)-12(t)15(a-)]TJ 0 Tw T* [(anal)35(y)-13(sis. )]TJ /T1_1 1 Tf -0.008 Tw 3.705 0 Td [(Chin Med J \(Eng)13.1(l\).)]TJ /T1_0 1 Tf [( 2019;132\(20\):2446\2262456. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.705 -1.25 Td (CM9.0000000000000485)Tj 0 0 0 1 k /GS1 gs 0.195 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, S\343o Jul)-30.9(i\343o)]TJ /Span<>> BDC ( )Tj EMC [(GP, Ma)15(t)-29.9(t)15(a)-17(cheo)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)14.9(t)17.1(or )]TJ 0.267 Tw -1.796 -1.25 Td [(A)-14(bd)-16(ominal )0.5(P)30(er)-36.9(ineal )0.5(E)35(x)-13(c)-24(ision )0.5(V)30(er)-10(sus )0.5(S)15(t)15(and)42(ar)-24(d )0.5(A)-14(bd)-16(ominal )0.5(P)30(er)-36.9(ineal )]TJ 0.012 Tc 0.442 Tw T* [(E)35(x)-12.9(c)-24(ision: Im)10(p)32(a)-17(c)-15.9(t on Q)-16(ual)-30.9(i)-24(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he R)13(esec)-16(ted Spec)-24(imen and)12( )]TJ 0.009 Tc 0.352 Tw T* [(P)9.6(ost)16.6(oper)-33.4(a)14.6(t)-32.3(i)-16.4(ve M)-24.4(or)-24.3(bidi)-24.4(t)-10.4(y. )]TJ /T1_1 1 Tf [(W)28.6(orld J Surg.)]TJ /T1_0 1 Tf [( 2017;41\(8\):2160\2262167.)9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00268-017-3963-1)Tj 0 0 0 1 k /GS1 gs -0.004 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(ad)-17(w)-12(an)]TJ /Span<>> BDC ( )Tj EMC [(RW, T)40(ang)]TJ /Span<>> BDC ( )Tj EMC [(AM, Har)-24(r)-36.9(ies)]TJ /Span<>> BDC ( )Tj EMC [(RL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)30(er)-22(t)-32(ical r)-23.9(ec)-16(tus abd)-16(ominis )]TJ 0.231 Tw -1.796 -1.25 Td [(fl)-16(ap )0.6(\(VRAM\) )0.6(for )0.5(per)-37(ineal )0.6(r)-24(econstr)-21.9(uc)-16(t)-32(ion )0.6(foll)30(o)-14(wing )0.6(pel)30(v)-16(ic )0.6(sur)-32(ger)-24(y: )]TJ 0.041 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC 0.828 0 Td [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf 7.809 0 Td [(J )0.5(Plast )0.5(R)21(econstr )0.5(Aesthet )0.6(Surg.)]TJ /T1_0 1 Tf [( )0.5(2021;74\(3\):523\226)]TJ 0.023 Tw -8.636 -1.25 Td [(529. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.bjps.2020.10.100)Tj 0 0 0 1 k /GS1 gs 0.013 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(asai)]TJ /Span<>> BDC ( )Tj EMC [(S, K)-15.9(a)-17(ga)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(H, S)-16(hiomi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inc)-24(idence and r)-37(isk f)16(a)-17(c)-16(t)17(or)-10(s for )]TJ 0.089 Tw -1.796 -1.25 Td [(per)-37(ineal her)-14.9(nia af)-28(ter r)-32(obo)17(t)-32(ic abd)-16(ominoper)-36.9(ineal r)-23.9(esec)-16(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC (single-)Tj 0.078 Tw T* [(center, r)-23.9(e)-12(tr)-32(ospec)-16(t)-32(i)-15.9(ve cohor)-22(t stud)17.1(y. )]TJ /T1_1 1 Tf [(T)54(ech Colop)46(roctol. )]TJ /T1_0 1 Tf 0 Tw (2024;28\(1\):79. )Tj 0.023 Tw T* [(P)20(ubl)-31(ished 2024 Jul 4. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-024-02961-z)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.401 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td (\206\035\026\007\t\001\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \204\024\017\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\213., \231\036\035\036\020\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\222., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 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\005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.017 Tw 10 0 0 10 42.5197 493.4479 Tm (\007\030\036\027\017\030\024\r\026\027\017\016, \004\026\f\021\024\021\026\ \031\f\023\036\001\027\t\b \017\f\b\024\007\024\r \f\024\f\021\026\r\035\ \016\035\026 )Tj 0 Tw 0 -1.218 TD (\035\017\001\034 30%.)Tj 0.16 Tw T* (\200 \027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017, \b\024\ \021\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \030\026\027\027\017\b \024\f)Tj 0 Tw (-)Tj 0.132 Tw T* (\035\024\032\027\036\027\017\005 \030\026\027\017\006\026 \027\036 \007\ \024\f\021\017\020\035\026 \f\021\026\021\017\f\021\017\004\036\f\022\024\ \005 \027\026)Tj 0 Tw (-)Tj 0.146 Tw T* [(\004\017\n\024\f\021\017, )0.5(\027\026\002\035\033\007\026\036\021\f\016 )0.6(\021\036\027\007\036\027\006\017\016 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 15.227 0 Td [(\036\036 )0.5(\031\n\036\027\034\001\036\027\017\033. )]TJ -15.227 -1.218 Td (\200\026\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\024\r\024\005 \023\035\026\f\021\017\022\017\ \030\036\032\036 )Tj -0.015 Tw T* [(\r\f\021\030\036\004\026\035\017\f\034 )0.5(\f\036\030\024\n\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\020\027\024\036\027\017\036, )0.5(\004\021\024 )0.5(\r\036\030\024\016\021\027\024 \f\r\016\026)]TJ 0 Tw (-)Tj 0.014 Tw T* (\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\t\n \026\023\024\035\027\036\027\017\ \036\n \023\024\035\024\f\021\017 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004)Tj 0 Tw (-)Tj 0.508 Tw T* (\001\036\027\017\036\n \007\030\036\027\017\030\024\r\026\027\017\016. \215\ \024\016\r\035\036\027\017\036 \027\036\022\030\024\026 \022\030\026\016\ )Tj 0.171 Tw T* (\035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (4% \f\035\031\004\026\036\r \023\024\007\004\201\030\022\017\r\026\036\021\ \027\036\024\002\b\024\007\017\n\024\f\021\034 )Tj 0.299 Tw T* (\021\013\026\021\036\035\034\027\024\005 \024\006\036\027\022\017 \r\026\ \f\022\031\035\016\030\017\026\006\017\017 \n\024\002\017\035\017\031\036\ \n\t\b )Tj 0 Tw T* (\021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\026\002\024\021\022\017 \021\036\b\027\017\022\017 \r\t\007\ \036\035\036\027\017\016 \035\024\f\022\031\021\026.)Tj 0.129 Tw T* (\215\030\017 \026\027\026\035\017\036 \024\021\007\026\035\201\027\027\t\ \b \030\036\031\035\034\021\026\021\024\r \024\021\n\036\004\036\027\026\ \021\036\027)Tj 0 Tw (-)Tj 0.296 Tw T* (\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t \023\024\007\027\ \017\b \024\f\035\024\032\027\036\027\017\005 )Tj 0.219 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\024\r\024\005 \023\035\026\f\021\017\022\017\ , \r\022\035\033\004\026\016 \023\030\024\n\036\032\027\024\f\021\027\031\ \033 )Tj -0.025 Tw T* (\020\030\t\032\031 \(2%, 8% \017)Tj /Span<>> BDC ( )Tj EMC (6%, \n\036\007\017\026\027\026 \007\035\017\021\036\035\034\027\024\f\021\ \017 \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\017\016 14 \n\036\f\016\006\036\r\). \233\021\024 \f\r\016\026\027\ \024 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\026\027\017\036\n \023\030\024\004\027\024\020\024 )Tj 0.037 Tw T* (\n\t\001\036\004\027\024-\235\026\f\006\017\026\035\034\027\024\020\024 \ \f\035\024\016, \031\022\030\036\023\035\016\033\013\036\020\024 \021\026\ \024\r\024\036 )Tj -0.009 Tw T* (\007\027\024, \021\024\020\007\026 \022\026\022 \023\030\024\f\021\024\036\ \031\001\017\r\026\027\017\036 \017\035\017 \031\f\021\026\027\024\r\022\ \026 \f\036\021\022\017 )Tj 0.037 Tw T* (\027\036 \r\f\036\020\007\026 \024\002\036\f\023\036\004\017\r\026\033\021\ \007\024\035\020\024\r\030\036\n\036\027\027\031\033 \023\024\007\007\036\ \030\032\022\031 )Tj 0.077 Tw T* ([26,27]. \222\024\020\035\026\f\027\024 \030\036\031\035\034\021\026\021\ \026\n \n\027\024\020\017\b \017\f\f\035\036\007\024\r\026\027\017\005, \ )Tj 0.125 Tw T* (\004\026\f\021\024\021\026 \030\026\r\017\021\017\016 \023\030\024\n\036\ \032\027\024\f\021\027\024\005 \020\030\t\032\017 \023\024\f\035\036 \023\ \030\017)Tj 0 Tw (-)Tj 0.088 Tw T* [(\n\036\027\036\027\017\016 )0.6(\030\026\035\017\004\027\t\b )0.5(\f\023\024\f\024\002\024\r )0.5(\023\035\026\f\021\017\022\017 )0.6(\023\024\f\035\036 )0.5(\233\035\207\215\233 )]TJ 0.095 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \022\024\035\036\002\035\036\ \021\f\016 \024\021 3,3% \007\024)Tj /Span<>> BDC ( )Tj EMC (67% [3,14,15]. )Tj 0.118 Tw T* (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \023\030\036\007\035\024\032\036\027\027\t\005 \027\026\n\017 \f\ \023\024)Tj 0 Tw (-)Tj 0.02 Tw T* (\f\024\002 \023\035\026\f\021\017\022\017 \016\r\035\016\036\021\f\016 \030\ \026\027\024\r\017\007\027\024\f\021\034\033 \027\036\f\r\024\002\024\007\ \027\024\005 )Tj 0.36 Tw T* (\026\031\021\024\023\035\026\f\021\017\022\017 \022\024\032\027\024-\n\t\ \001\036\004\027\t\n\017 \035\024\f\022\031\021\026\n\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.003 Tw T* (\023\024\035\034\024\r\026\027\017\036 \017\n\036\027\027\024 \220\021\017\ \b \n\036\021\024\007\017\022 \023\024\r\024\035\016\036\021 \f\027\017\ \017\021\034 )Tj 0.151 Tw T* (\030\017\f\022\017 \235\024\030\n\017\030\024\r\026\027\017\016 \023\030\ \024\n\036\032\027\024\f\021\027\024\005 \020\030\t\032\017 [2,28]. )Tj -0.026 Tw T* (\233\235\235\036\022\021\017\r\027\024\f\021\034 \007\026\027\027\024\005\ \021\036\b\027\017\022\017 \026\022\030\t\021\017\016 \030\026\027\t \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\035\026)Tj 0 Tw (-)Tj 0.036 Tw T* [(\027\036 )0.5(\004\026\f\021\024\021\t \030\026\r\017\021\017\016 )0.5(\023\030\024\n\036\032\027\024\f\021\027\024\005 )0.6(\020\030\t\032\017 )0.5(\f\024\023\024\f\021\026)]TJ 0 Tw (-)Tj T* (\r\017\n\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \f\036\021\004\026\021\t\b \017\ \n\023\035\026\027\021\024\r [29,30].)Tj 0.308 Tw T* (\211\035\031\004\001\036\027\017\036 \022\026\004\036\f\021\r\036\027\027\ \t\b \023\024\022\026\026\021\036\035\036\005 \032\017\027\017, \024\f\ \024)Tj 0 Tw (-)Tj 0.004 Tw T* (\002\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\026\f\023\036\022\021\036 \002\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\020\024 \r\024\f\023\030\017\016\021\017\016 \007\024\030\ \024\r\034\016, )Tj 0.126 Tw T* (\016\r\035\016\036\021\f\016 \022\035\033\004\036\r\t\n \026\030\020\031\ \n\036\027\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \r\027\036\007\030\036\027\017\016 )Tj -0.037 Tw 23.244 41.405 Td (\007\026\027\027\024\005 \n\036\021\024\007\017\022\017. \230\n\036\027\027\ \024 \220\021\017 \023\026\030\026\n\036\021\030\t \024\023\030\036\007\036\ \035\016\033\021 )Tj 0.081 Tw T* (\031\f\023\036\b \030\036\026\002\017\035\017\021\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\r\030\026\013\036\027\017\036 \023\026\006\017\036\027\021\026 \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\035)Tj 0 Tw (-)Tj -0.022 Tw T* (\027\024\006\036\027\027\024\005 \032\017\027\017 \023\024\f\035\036 \021\ \026\022\024\005 \021\016\032\036\035\024\005 \024\023\036\030\026\006\017\ \017 [31].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 432.5579 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.634 Tw 10 0 0 10 274.9606 408.2019 Tm [(\215\030\036\007\035\024\032\036\027\027\t\005 )0.6(\f\023\024\f\024\002 )0.5(\023\035\026\f\021\017\022\017 )0.6(\023\030\024\n\036\032\027\024\f\021\027\024\005 )]TJ 0.033 Tw T* (\030\026\027\t \023\024\f\035\036 \233\035\207\215\233 \023\030\016\n\024\ \005 \022\017\001\022\017, \024\f\027\024\r\026\027\027\t\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.164 Tw T* (\023\024\035\034\024\r\026\027\017\017 \007\036\220\023\017\021\036\035\ \017\017\030\024\r\026\027\027\024\020\024 \022\024\032\027\024-\023\024\ \007\022\024\032)Tj 0 Tw (-)Tj 0.57 Tw T* [(\027\024-\235\026\f\006\017\026\035\034\027\024\020\024 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.337 0 Td [(\023\036\030\036\n\036\013\036\027\027\024\020\024 )0.6(\021\030\036\031\020\024\035\034\027\024\020\024 )]TJ 0.303 Tw -9.337 -1.218 Td (\035\024\f\022\031\021\024\r, \023\030\036\007\f\021\026\r\035\016\036\021\ \f\024\002\024\005 \220\235\235\036\022\021\017\r\027\t\005 \n\036\021\024\ \007 )Tj 0.215 Tw T* (\030\036\022\024\027\f\021\030\031\022\006\017\017. \213\020\024 \023\030\ \017\n\036\027\036\027\017\036 \023\024\r\024\035\016\036\021 \f\027\017\ \017\021\034 )Tj 0.307 Tw T* (\017\027\021\036\027\f\017\r\027\024\f\021\034 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\005 \002\024\035\017, \031\035\031\004\ \001\017\021\034 )Tj 0.309 Tw T* [(\022\026\004\036\f\021\r\024 )0.5(\032\017\027\017 )0.6(\023\026\006\017\036\027\021\024\r )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.246 0 Td [(\024\021\007\026\035\036\027\027\024\n )0.6(\023\036\030\017\024\007\036 )]TJ 0.017 Tw -13.246 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\n\024\027\f\021\030\017\030\031\036\021 \021\036\027\007\036\027\ \006\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t \022\026\022 )Tj 0.034 Tw T* (\030\026\027\027\017\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\b \024\f\035\024\032\027\036\027\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \023\030\024)Tj 0 Tw (-)Tj T* (\n\036\032\027\024\f\021\027\t\b \020\030\t\032.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.026 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.024 Tc 0.05 Tw [( \004)-15.2(\031)-13.8(\f)-20.7(\031)-14.4(\021)-18.5(\022)-16.8(\025)-13.3(\n)-11.3(\022)-16.8(\025)]TJ /Span<>> BDC 20.061 0 Td ( )Tj EMC [(\211.)4.5(\211.)-16.2(,)-24( )]TJ -0.005 Tc 0.005 Tw -20.061 -1.218 Td [(\220)3.4(\031\032)-4.9(\031\025)5.1(\022)2.2(\025)]TJ /Span<>> BDC 3.495 0 Td ( )Tj EMC [(\001)23.8(.)23.5(\211)19.3(.)]TJ /T1_1 1 Tf 0 Tc 0.554 Tw -3.495 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 )0.5(\n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_4 1 Tf -0.024 Tc 0.578 Tw [( )0.5(\004)-15.2(\031)-13.9(\f)-20.7(\031)-14.4(\021)-18.5(\022)-16.8(\025)-13.2(\n)-11.4(\022)-16.7(\025)]TJ /Span<>> BDC 19.533 0 Td ( )Tj EMC 0.787 0 Td [(\211.)4.5(\211.)-16.2(,)-24( )]TJ 0 Tc 0.426 Tw -20.319 -1.218 Td [(\220)8.4(\031)4.9(\032\031)5.3(\025)10.1(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)28.5(\211)24.3(.)7.8(, \237)14.1(\022)4.8(\032)3(\020)-5.2(\f)9.6(\022)3.8(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\206)93.9(.)20.1(\215)19.4(.)47.3(-)-0.9(\003)-2.3(.)7.8(, \202)16.1(\020)-3.3(\r)9.3(\213)6.2(\020)4.4(\025)3.2(\024)4.1(\n)12.7(\022)10.1(\235 \211)24.3(.)27.5(\221)-4.4(, )]TJ -0.01 Tc 0.01 Tw T* [(\036)11.9(\032)-7.7(\026)-3.1(\020)-5.1(\n\031\021)]TJ /Span<>> BDC 3.352 0 Td ( )Tj EMC [(\036)12.8(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0.018 Tc -0.018 Tw -3.352 -1.218 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0.002 Tc -0.002 Tw 11.349 0 Td [( \225)18.6(\020)-3.2(\f)11.1(\020)2.9(\203)13(\t)12.2(\025)]TJ /Span<>> BDC 3.727 0 Td ( )Tj EMC [(\003.)9.3(\003.)]TJ /T1_1 1 Tf -15.076 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \004)8.8(\031)10.1(\f)3.4(\031)9.6(\021)5.5(\022)7.2(\025)10.7(\n)12.7(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)28.6(\211)24.3(.)7.8(, \220)8.4(\031)4.9(\032\031)5.3(\025)10.1(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.9(.)28.5(\211)24.3(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.024 Tc 0.024 Tw [( \004)-15.2(\031)-13.9(\f)-20.7(\031)-14.4(\021)-18.4(\022)-16.8(\025)-13.3(\n)-11.3(\022)-16.8(\025)]TJ /Span<>> BDC 12.224 0 Td ( )Tj EMC [(\211.)4.5(\211.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -12.224 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.081 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf -0.008 Tc 0.089 Tw [( V)17.9(a)-12.5(d)-6.6(im)]TJ /Span<>> BDC 16.442 0 Td ( )Tj EMC [(V)45.1(.)]TJ /Span<>> BDC 1.036 0 Td ( )Tj EMC [(P)17(o)-9.1(l)-5.1(o)-8.6(v)-36.6(ink)-26.5(in)-14(,)-8( )]TJ 0.008 Tw -17.478 -1.218 Td [(Nik)4.9(o)-9(l)-4.7(a)-13.9(y)]TJ /Span<>> BDC 2.904 0 Td ( )Tj EMC [(V)45.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(D)-14.1(o)-6.7(r)-5.6(o)-7.5(n)-1.8(in)5.6(.)]TJ /T1_1 1 Tf 0 Tc 0.194 Tw -3.859 -1.218 Td [(D)-1.6(a)-8.4(t)-27.7(a c)3.7(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.8(g)9(:)]TJ /T1_4 1 Tf -0.008 Tc 0.202 Tw [( V)17.9(a)-12.5(d)-6.6(i)0.5(m)]TJ /Span<>> BDC 16.215 0 Td ( )Tj EMC [(V)45.2(.)]TJ /Span<>> BDC 1.149 0 Td ( )Tj EMC [(P)17(o)-9(l)-5.1(o)-8.6(v)-36.6(ink)-26.5(i)0.5(n)-14(,)-8( )]TJ 0 Tc 1.094 Tw -17.364 -1.218 Td [(N)8(i)7.9(k)12.9(o)-1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-6.1(o)1.3(r)2.4(on)6.2(i)8.4(n)-6(, R)10.2(us)9.3(l)3.3(a)-0.8(n M)5.4(.)47.2(-)-8.2(A)-12.6(. S)15.4(h)6.2(i)9.4(r)7.7(al)4.3(iy)0.9(e)-4(v)33.6(, )]TJ 0 Tw T* [(V)25.9(al)4.8(e)-1.7(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(B)10.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)1.8(us)9.6(h)4.9(a)-0.8(n)8.1(s)9.1(k)-18.5(iy)16.5(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(E)22(r)-14.6(m)4.3(a)1.7(k)12.9(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.028 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \031\006\027\025\n\022 \n\020\007\027\ \024\023\021\020 \255\022\016\025\022 \033\020\006\022\027\025\023\031\021\ \024\032\020\021\025\022\021\020\027\026\013\200 \b\032\r\033\033 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\026\031\212\017\005 \027\021\032\031\033\027\235\024\n\031\b\031\ \031\033\032\031\024\025\022\n\020 \n\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\007\027\024\023\021\020 \255\022\016\025\022 EQ-5D \021)Tj /Span<>> BDC ( )Tj EMC (\021\027\032\024\022\022 EQ-5D-3L)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.115 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.088 Tw 3.417 0 Td [( R)2.8(e)-22(s)6.7(u)-1.6(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-7.2(s)-10.5(s)0.5(e)-22(s)-10.5(s)-12.5(i)3.9(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(q)-3(ua)-4.5(li)-3.4(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(li)5.1(f)-13.4(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.9(o)-4(m)-1(p)-6.3(a)-4.2(r)-2(e)-12.9(d g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s u)-4.4(s)-12.5(i)3.9(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(E)20.6(u)1.6(r)-2(o)-5.3(p)-11.3(e)-7.5(a)-5.1(n E)21.9(Q)-31.4(-5)13.8(D Q)-10.1(ua)-4.5(li)-3.4(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(L)-1.2(i)5.1(f)-13.4(e )]TJ 0 Tw -3.417 -1.2 Td [(q)-3(u)-3.2(e)-22(s)-14.8(t)-29.1(i)-1.3(o)-4(n)0.8(na)-6.3(i)4.9(r)-2(e i)3.9(n t)-10.6(h)-2.3(e)]TJ /Span<>> BDC ( )Tj EMC [(E)21.9(Q)-31.4(-5)13.8(D)-28.5(-)22.7(3)18(L v)2.3(e)-6(r)-14.8(s)-12.5(i)-1.4(o)-4(n)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 241.1949 693.581 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 303.5571 693.581 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 374.4232 693.581 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.124 693.581 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 662.9118 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 662.9118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 662.9118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 662.9118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 662.9118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 641.8425 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 641.8425 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 641.8425 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 641.8425 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 641.8425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 620.7733 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 620.7733 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 620.7733 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 620.7733 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 620.7733 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 599.7041 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 599.7041 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 599.7041 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 599.7041 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 599.7041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 578.6349 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 578.6349 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 578.6349 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 578.6349 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 578.6349 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 557.5657 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 557.5657 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 557.5657 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 557.5657 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 557.5657 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 536.4965 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 241.1949 536.4965 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 303.5571 536.4965 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 536.4965 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 448.124 536.4965 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 120.5865 675.3465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.557 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_5 1 Tf 2.091 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj -0.01 Tw 5.578 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_5 1 Tf 0 Tw 2.749 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.204 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_5 1 Tf 1.724 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_5 1 Tf 6.484 1.2 Td (\t)Tj /T1_3 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (D1-\200\002\240\t\202\b\002\217\003\001 EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.612 0.001 Td (1,5)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.669 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,37)Tj /T1_3 1 Tf -52.484 -2.635 Td (D2-\255\004\214\002\002\206\217\f\210\202\t\004\b\t\r EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.327 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,34)Tj /T1_3 1 Tf -0.004 Tw -52.484 -2.635 Td [(D3-\032\220\003\t\b\002\217\003\001 )0.5()]TJ /Span<>> BDC ( )Tj EMC 7.475 0 Td [(\212\002\217\r\240\b\r\b\002\005 )0.5(\202\t\213\b\t )0.5(EQ-5D-3L,)]TJ /T1_4 1 Tf [( )0.5(\240\020\f\f\013)]TJ 0 Tw -7.475 -1.2 Td (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.327 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,24)Tj /T1_3 1 Tf -52.484 -2.635 Td (D4-\224\002\f\001 \t)Tj /Span<>> BDC ( )Tj EMC (\240\t\217\220\002\214\226\002\006\003 EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;1\))Tj 8.327 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 7.301 1.2 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_3 1 Tf -51.618 -2.635 Td (D5-\224\r\217\212\002\220\002\005\217\003\002 \t\f\t \240\r\212\006\r\217\ \217\t\235 EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj 0 -1.2 TD (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.327 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,54)Tj /T1_3 1 Tf -52.484 -2.635 Td (EQ-VAS, )Tj /T1_4 1 Tf (\240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.204 0.001 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(70;85\))Tj 8.327 0 Td (70)Tj /Span<>> BDC ( )Tj EMC (\(65;75\))Tj 9.035 0 Td (70)Tj /Span<>> BDC ( )Tj EMC (\(65;75\))Tj 8.051 1.2 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_4 1 Tf 7 0 0 7 42.5197 525.0118 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.8644 56.0378 Tm (89)Tj ET endstream endobj 1102 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.138 Tw 10 0 0 10 70.8661 578.6938 Tm (\031\001\017\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \(14% \(7/50\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 )Tj 0.167 Tw 0 -1.218 TD (\f\036\021\004\026\021\024\020\024 \220\027\007\024\023\030\024\021\036\ \026 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.167 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\026\035\017\026\006\017\017 )Tj 0.366 Tw T* (\f\021\030\031\022\021\031\030\t \023\024\007\027\017\b \024\f\035\024\032\ \027\036\027\017\005 \027\026\002\035\033\007\026\036\021\f\016 \021\036\ \027)Tj 0 Tw (-)Tj 0.009 Tw 0 -1.218 TD (\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t \017\b \r\024\027\ \017\022\027\024\r\036\027\017\016 \023\024\f\035\036 )Tj 0 Tw 0 -1.218 TD (\023\030\017\n\036\027\036\027\017\016 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 \023\035\026\f\021\017\022\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\))Tj 0.002 Tc 0.504 Tw 0 -1.218 TD (\222\035\024\032\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\026\032\017\r\035\036\027\017\036\n \023\030\024\n\036\032\027\024\f\021\ \027\024\005 \030\026\027\t)2( )]TJ 0.59 Tw 0 -1.218 TD [(\f\021\026\035\017 \023\030\017\004\017\027\024\005 \007\035\016 \023\024\ \r\021\024\030\027\024\005 \020\024\f\023\017\021\026\035\017\026\006\017\ \017)2( )]TJ 0.228 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024)Tj /Span<>> BDC ( )Tj EMC 3.757 0 Td (\027\026\030 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\020\024 \f\023\024\f\024\002\026)2( )]TJ 0.066 Tw -3.757 -1.218 Td [(\023\035\026\f\021\017\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.846 0 Td [(2% )0.5(\(1/50\) )0.5(\027\026\002\035\033\007\036\027\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.982 0 Td [(\020\030\031\023\023\036 )0.5(\023\030\024\f\021\024)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.154 Tw -15.828 -1.218 Td (\020\024 \031\001\017\r\026\027\017\016 \030\026\027\t \021\026\022\032\036\ \r)Tj /Span<>> BDC ( )Tj EMC [(2% \(1/50\) \027\026\002\035\033\007\036\027\017\005.)2( )]TJ 0.218 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\026\n, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\017\n\036\027\016\035\026\f\034 \023\035\ \026\f\021\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.317 Tw T* (\023\024\035\034\024\r\026\027\017\036\n \f\036\021\004\026\021\024\020\ \024 \220\027\007\024\023\030\024\021\036\026, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\n)2( )]TJ 0.097 Tw T* [(\f\035\031\004\026\036 \027\036 \023\024\021\030\036\002\024\r\026\035\026\ \f\034 \023\024\r\021\024\030\027\026\016 \020\024\f\023\017\021\026\035\ \017\026\006\017\016)2( )]TJ 0 Tc 0 Tw T* (\()Tj /T1_1 1 Tf 0.372 0 Td (\032)Tj /T1_0 1 Tf 0.002 Tc /Span<>> BDC 0.48 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,60\).)Tj 0 Tc 0.123 Tw -0.852 -1.218 Td (\207\024\035\036\r\024\005 \f\017\027\007\030\024\n, \f\024\b\030\026\027\ \016\033\013\017\005\f\016 \002\024\035\036\036 3 \n\036\f\016\006\036\r\ , )Tj 0.215 Tw T* (\030\036\032\036 \027\026\002\035\033\007\026\035\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 )Tj 0.204 Tw T* (\023\035\026\f\021\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\t\n \031\001\017\r\026\027\017\036\n \030\026\027\t, \ )Tj 0.142 Tw T* [(\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\026\016 \027\026\004\ \017\n\024\f\021\034 )0.5(\220\021\024\020\024 \024\021\035\017\004\017\016 )0.5(\027\036 \007\024)]TJ 0 Tw (-)Tj 0.08 Tw T* (\f\021\017\020\027\031\021\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \023\035\026\f\021\017\022\ \017 \f\036\021\004\026\021\t\n \220\027)Tj 0 Tw (-)Tj 0.246 Tw T* (\007\024\023\030\024\021\036\024\n \004\026\f\021\024\021\026 \r\f\021\030\ \036\004\026\036\n\024\f\021\017 \220\021\024\020\024 \f\017\027\007\030\ \024\n\026 )Tj 0.169 Tw T* (\002\t\035\026 \023\030\026\022\021\017\004\036\f\022\017 \021\026\022\026\ \016 \032\036, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\030\017\n\036\027\036\027\017\017 )Tj 0 Tw T* (\027\024\r\024\020\024 \f\023\024\f\024\002\026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj /T1_2 1 Tf 0 -2.436 TD (\017\204\r\b\220\004 \220\004\201\r\217\003\004 \202\t\213\b\t \212\004\ \204\t\r\b\003\002)Tj /T1_0 1 Tf -0.05 Tw 0 -1.218 TD [(\200 \030\036\031\035\034\021\026\021\036 \026\027\026\035\017\026 )0.5(\f\021\030\031\022\021\031\030\t \024\006\036\027\022\017 )0.5(\022\026\004\036\f\021\r\026 \032\017)]TJ 0 Tw (-)Tj 0.062 Tw T* [(\027\017 )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.5(\004\021\024 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 9.906 0 Td [(\022\024\n\023\024\027\036\027\021\026\n )0.6(\253\215\024\007\r\017\032\027\024\f\021\034\273 )]TJ 0.218 Tw -9.906 -1.218 Td (\(D1\), \253\222\026\n\024\024\002\f\035\031\032\017\r\026\027\017\036\273\ \(D2\), \253\202\022\021\017\r\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.233 Tw T* (\r\f\036\007\027\036\r\027\024\005 \032\017\027\017\273 \(D3\) \017)Tj /Span<>> BDC ( )Tj EMC (\253\207\036\f\023\024\022\024\005\f\021\r\024 \017\035\017 \007\036)Tj 0 Tw (-)Tj 0.12 Tw T* (\023\030\036\f\f\017\016\273 \(D5\) \f\030\026\r\027\017\r\026\036\n\t\036\ \020\030\031\023\023\t \027\036 \024\021\035\017\004\026\035\017\f\034,\ )Tj 0.168 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\017\005 \002\026\035\035 \024\006\036\027\022\017 \027\ \026\b\024\007\017\035\f\016 \002\035\017\032\036 \022)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\033 )Tj 0.649 Tw T* (\253\027\036\027\026\004\017\021\036\035\034\027\026\016 \023\030\024\002\ \035\036\n\026\273. \222\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026)Tj 0 Tw (-)Tj 0.196 Tw T* (\004\017\n\024\036 \024\021\035\017\004\017\036 \f\030\036\007\027\017\b\ \027\026\004\036\027\017\005 \002\026\035\035\034\027\024\005 \024\006\ \036\027\022\017 )Tj 0.134 Tw T* (\002\t\035\024 \r\t\016\r\035\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\024\027\036\027\021\036 \253\207\024\035\034 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\022\024\n\235\024\030\021\273 )Tj 0.05 Tw T* (\(D4\). \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\020\024 \f\023\024\f\024\002\026 \023\035\026\f\021\017\022\017 )Tj -0.044 Tw 0 -1.218 TD (\f\030\036\007\027\017\005 \002\026\035\035 \024\006\036\027\022\017 \002\ \t\035 \023\030\026\022\021\017\004\036\f\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \253\027\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\026\004\017\021\036\035\034\027\026\016 \023\030\024\002\035\036\n\ \026\273, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\030\024\f\021\024)Tj (-)Tj 0.098 Tw 0 -1.218 TD (\020\024 \031\001\017\r\026\027\017\016 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\016 \023\035\026\f\021\017\022\017 \f\ \036\021\004\026\021\t\n )Tj 0.104 Tw 0 -1.218 TD [(\220\027\007\024\023\030\024\021\036\024\n )0.6(\002\035\017\032\036 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 9.892 0 Td [(\031\030\024\r\027\033 )0.5(\253\027\026\004\017\021\036\035\034\027\026\016 )0.7(\023\030\024\002)]TJ 0 Tw (-)Tj -9.892 -1.218 Td (\035\036\n\026\273 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.153 Tw 0 -1.218 TD (\025\030\024\n\036 \021\024\020\024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\r\026\036\n\t\b \020\030\031\023\023\026\b \r\t\016\ \r\035\036\027\024 \f\021\026)Tj 0 Tw (-)Tj 0.52 Tw 0 -1.218 TD [(\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\036 )0.5(\024\021\035\017\004\017\036 \f\030\036\007\027\017\b \027\026\004\036\027\ \017\005 )]TJ 0.357 Tw 0 -1.218 TD (\030\036\005\021\017\027\020\026 \021\036\022\031\013\036\020\024 \f\024\ \f\021\024\016\027\017\016 \007\024\030\024\r\034\016. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj -0.077 Tw 23.244 49.93 Td (\023\030\017\n\036\027\036\027\017\016 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 \023\035\026\f\021\017\022\017 \023\026\006\017\036\027\021\ \t \f\031\013\036)Tj 0 Tw (-)Tj 0.129 Tw 0 -1.218 TD [(\f\021\r\036\027\027\024 )0.6(\r\t\001\036 )0.5(\024\006\036\027\017\r\026\035\017 )0.5(\021\036\022\031\013\036\036 )0.6(\f\024\f\021\024\016\027\017\036 )0.5(\007\024\030\024)]TJ 0 Tw (-)Tj -0.005 Tw T* (\r\034\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \023\030\017\n\036\027\036\027\017\016 )Tj 0.089 Tw 0 -1.218 TD (\023\030\024\f\021\024\020\024 \031\001\017\r\026\027\017\016 \030\026\027\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t, \020\007\036 \023\030\017\n\036\027\016\035\026\f\ \034 )Tj 0 Tw 0 -1.218 TD (\023\035\026\f\021\017\022\026 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024\021\036\024\n \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.415 Tw 10 0 0 10 303.3071 469.0918 Tm (\217\036\031\035\034\021\026\021\t \023\030\036\007\f\021\026\r\035\036\ \027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \f\r\017\ \007\036)Tj 0 Tw (-)Tj 0.159 Tw 0 -1.218 TD (\021\036\035\034\f\021\r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \023\030\036\007\035\024\032\036\027\027\t\005 \ \027\024\r\t\005 \f\023\024\f\024\002 )Tj 0.017 Tw T* (\023\035\026\f\021\017\022\017 \023\030\024\n\036\032\027\024\f\021\027\024\ \005 \030\026\027\t \016\r\035\016\036\021\f\016 \023\036\030\f\023\036\022\ \021\017\r)Tj 0 Tw (-)Tj 0.155 Tw T* (\027\024\005 \n\036\021\024\007\017\022\024\005 \030\036\022\024\027\f\021\ \030\031\022\006\017\017 \023\024\f\035\036 \233\035\207\215\233 \023\030\ \016\n\024\005 )Tj 0.205 Tw T* (\022\017\001\022\017. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\036 \r\030\036\n\036\027\017, \026\021\ \030\026\004\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\r\026\036\n\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\004\036\f\022\017\005 \220\021\026\023, \004\021\024\ \016\r\035\016\036\021\f\016 \024\032\017\007\026)Tj 0 Tw (-)Tj 0.031 Tw T* (\036\n\t\n \007\035\016 \002\024\035\036\036 \021\036\b\027\017\004\036\f\ \022\017 \f\035\024\032\027\t\b \030\036\022\024\027\f\021\030\031\022\006\ \017\005, )Tj -0.014 Tw T* [(\036\020\024 )0.5(\023\030\017\n\036\027\036\027\017\036 )0.5(\023\024\r\024\035\016\036\021 )0.6(\007\024\f\021\017\004\034 )0.5(\030\016\007\026 )0.5(\022\035\017\027\017\004\036\f\022\017\b )]TJ 0 Tw T* (\023\030\036\017\n\031\013\036\f\021\r.)Tj 0.087 Tw T* (\203\026\017\002\024\035\036\036 \r\026\032\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\023\024\007\021\r\036\030\032\007\201\027\027\t\n )]TJ 0.335 Tw T* [(\023\030\036\017\n\031\013\036\f\021\r\024\n )0.6(\016\r\035\016\036\021\f\016 )0.5(\f\027\017\032\036\027\017\036 )0.6(\017\027\021\036\027\f\017\r\027\024\f\021\017 )]TJ 0.09 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 \002\024\ \035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\005 \023\036\030\017\024\007. \204\t \f\r\016)Tj 0 Tw (-)Tj -0.036 Tw T* [(\t\r\026\036\n \220\021\024\021 )0.5(\220\235\235\036\022\021 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\017\027\006\017\023\017\026\035\034\027\024 )0.5(\017\027\t\n )0.5(\023\024\007\b\024\007\024\n )]TJ -0.033 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\033 \007\036\235\036\022\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \023\030\024\f\021\024\020\024 \031\ \001\017\r\026\027\017\016 )Tj 0.047 Tw T* (\030\026\027\t, \f\024\002\f\021\r\036\027\027\024, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\017 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\021\036\024\n, \021\030\036\002\031\033\013\017\b \023\024\f\035\024\005\ \027\024\020\024 \f\024\023\024\f\021\026\r\035\036\027\017\016 \021\022\ \026\027\036\005 )Tj -0.035 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\016\032\036\027\017\036\n, \027\024\r\t\005 \n\036\021\024\007\ \023\024\r\024\035\016\036\021 \017\002\036\032\026\021\034 \220\021\024\ \020\024 )Tj 0.225 Tw T* (\027\036\032\036\035\026\021\036\035\034\027\024\020\024 \220\235\235\036\ \022\021\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \023\036\030\036\n\036\013\036\027\017\016 \035\024)Tj 0 Tw (-)Tj 0.154 Tw T* (\f\022\031\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\016 \253\n\201\030\021\r\024\020\024\273\ \023\030\024\f\021\030\026\027\f\021\r\026 \024\002\255)Tj 0 Tw (-)Tj 0.442 Tw T* (\201\n\027\t\n\017, \b\024\030\024\001\024 \r\026\f\022\031\035\016\030\017\ \017\030\024\r\026\027\027\t\n\017 \021\022\026\027\016\n\017. )Tj 0.373 Tw T* (\233\021\024 \023\024\035\027\024\f\021\034\033 \f\024\024\021\r\036\021\ \f\021\r\031\036\021 \024\002\013\036\b\017\030\031\030\020\017\004\036\f\ \022\024\n\031 )Tj 0.102 Tw T* (\023\030\017\027\006\017\023\031)Tj /Span<>> BDC ( )Tj EMC 4.338 0 Td [(\227 )0.5(\030\036\022\024\027\f\021\030\031\022\006\017\016 )0.6(\002\036 )0.5(\027\026\021\016\032\036\027\017\016, )0.6(\f\023\024\f\024\002)]TJ 0 Tw (-)Tj 0.15 Tw -4.338 -1.218 Td (\f\021\r\031\016 \031\f\023\036\001\027\024\n\031 \026\032\017\r\035\036\ \027\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \002\024\035\036\r\024\005 )Tj 0 Tw T* (\017\n\023\031\035\034\f\026\006\017\017 [24].)Tj 0.144 Tw T* (\025\030\024\n\036 \021\024\020\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\024\n \031\001\017\r\026\027\017\017 \030\026\027\t \021\ \026\022\032\036 \022\026\022 )Tj 0.208 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\017 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024\021\036\024\n \f\031\013\036\f\021\r\031\036\021 \r\t)Tj 0 Tw (-)Tj 0.072 Tw T* (\f\024\022\017\005 \030\017\f\022 \030\026\r\017\021\017\016 \030\026\027\ \036\r\024\005 \017\027\235\036\022\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016)Tj 0 Tw (-)Tj 0.267 Tw T* [(\021\036\035\034\027\024\f\021\017 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\001\r\026. )0.5(\230\f\f\035\036\007\024\r\026\027\017\036 )]TJ 0.036 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\023\036\030\r\017\004\027\024\020\024 \023\030\024\f\021\024\020\024 \031\ \001\017\r\026\027\017\016, \023\030\024)]TJ 0 Tw (-)Tj 0.02 Tw T* (\r\036\007\036\027\027\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (1975 \020\024\007\031 [25], \023\024\022\026\026\035\024, \004\021\024 \ \026\031\021\024\023\035\026\f\021\017)Tj 0 Tw (-)Tj 0.245 Tw T* [(\022\026 \024\002\036\f\023\036\004\017\r\026\036\021 \026\032\017\r\035\ \036\027\017\036 )0.5(\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t )]TJ 0.02 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 3 \n\036\f\016\006\036\r \r)Tj /Span<>> BDC ( )Tj EMC (67\22668% \027\026\002\035\033\007\036\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\r \021\036\004\036)Tj 0 Tw (-)Tj 0.068 Tw T* (\027\017\036 6 \n\036\f\016\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (80%. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \024\021\022\030\t\021\024\020\024\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \004\031\016\030\025\022\027 \031\024\f\031\255\025\027\025\022\t \016\020\ \255\022\021\f\027\025\022\t \033\032\031\026\027\255\025\031\024\023\025\ \031\235 \032\020\025\013 \r)Tj /Span<>> BDC ( )Tj EMC 28.685 0 Td (\033\020\006\022\027\025\023\031\021 \b\032\r\033\033 \024\032\020\021\025\ \027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw -28.685 -1.2 Td [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.323 0 Td [( L)-8.8(a)-9.2(t)-1.5(e c)2.8(o)-4(m)-1(p)-4.9(li)-1.8(c)3.3(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-11.3(e)-5.9(r)-39(i)3.9(n)-2.4(e)-7.5(a)-4.5(l w)2.2(o)-3.4(u)0.7(n)-4.9(d h)-2.3(e)-7.5(a)-4.5(li)3.9(n)-0.6(g i)3.9(n p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e c)2.8(o)-4(m)-1(p)-6.3(a)-4.1(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.9351 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 684.5118 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 246.8642 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 323.3996 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 399.9351 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 476.4705 684.5118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 524.6594 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 70.8661 625.0426 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 625.0426 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 625.0426 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 625.0426 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 625.0426 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 613.5734 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 613.5734 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 613.5734 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 613.5734 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 476.4705 613.5734 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 137.5944 696.9465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.025 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_4 1 Tf 2.091 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.813 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_4 1 Tf 2.754 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.736 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_4 1 Tf 1.724 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_4 1 Tf 6.661 1.2 Td (\t)Tj /T1_2 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (\200\002\213\240\b\t\r \002\217\f\002\202\b\r\b\t\235 \213\004\202\t\f\r\ \b\t\235 )Tj 0 -1.2 TD (\212\006\002\214\r\202\b\002\217\003\b\002\005 \006\004\b\013)Tj /T1_0 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj T* (\026\002\f\006\036\f\f)Tj T* (\f\r\017\013)Tj T* (\020\030\t\032\026)Tj 23.469 3.601 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(98%\))Tj 1.616 -1.2 Td (0)Tj T* (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.067 3.6 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj T* (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 9.067 3.6 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 1.616 -1.2 Td (0)Tj -1.116 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 8.319 6 Td (0,22)Tj /T1_2 1 Tf -52.484 -7.435 Td (\224\002\f\r\002\005 \217\t\b\240\006\002\214 \206\002\f\r\r 3 \214\r\217\ \235\204\r)Tj /T1_0 1 Tf 25.032 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 9.317 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.817 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 8.319 0 Td (0,28)Tj /T1_1 1 Tf 7 0 0 7 70.8661 602.0887 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC (\227 \n\032\022\023\027\032\022\235 \250)Tj 4.081 0 0 4.081 156.7616 604.4197 Tm (2)Tj 7 0 0 7 158.8021 602.0887 Tm ( \004\022\032\024\031\025\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 28.1526 56.0378 Tm (88)Tj ET endstream endobj 1101 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.08 Tw 10 0 0 10 42.5197 262.0659 Tm (\217\026\027\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\036 \024\f\035\024\032\027\036\027\017\016 \f\024 \f\021\024\030\ \024\027\t )Tj -0.105 Tw 0 -1.218 TD (\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t \023\024\ \f\035\031\032\017\035\017 \023\030\017\004\017\027\024\005 \023\024\r\021\ \024\030\027\024\005 )Tj -0.029 Tw T* (\024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (6% \(3/50\) \027\026\002\035\033\007\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036)Tj 0 Tw (-)Tj -0.02 Tw T* [(\027\017\016 )0.6(\027\024\r\024\020\024 )0.5(\f\023\024\f\024\002\026 )0.5(\023\035\026\f\021\017\022\017, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.174 0 Td [(10% )0.5(\(5/50\))]TJ /Span<>> BDC ( )Tj EMC 4.867 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 1.899 0 Td (\020\030\031\023)Tj 0 Tw (-)Tj 0.005 Tw -19.94 -1.218 Td (\023\036 \023\030\024\f\021\024\020\024 \031\001\017\r\026\027\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r 12% \(6/50\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\f)Tj 0 Tw (-)Tj T* (\023\024\035\034\024\r\026\027\017\016 \f\036\021\004\026\021\024\020\024\ \220\027\007\024\023\030\024\021\036\026 \030\026\027\t \()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,58\).)Tj 0.352 Tw T* [(\210\021\027\024\f\017\021\036\035\034\027\024 )0.6(\021\016\032\036\f\021\017 )0.5(\030\026\027\027\017\b )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )]TJ 0.837 Tw T* [(\024\f\035\024\032\027\036\027\017\005, )0.6(\f\024\020\035\026\f\027\024 )0.5(\022\035\026\f\f\017\235\017\022\026\006\017\017 )0.6(Cl)-16(av)-15.9(ien\226)]TJ 0.146 Tw T* [(Dind)-16(o, \024\f\035\024\032\027\036\027\017\016 II \017)]TJ /Span<>> BDC ( )Tj EMC (IV \f\021\036\023\036\027\017 \r\024 \r\f\036\b \f\030\026\r\027\017)Tj 0 Tw (-)Tj 0.06 Tw T* (\r\026\036\n\t\b \020\030\031\023\023\026\b \r\f\021\030\036\004\026\035\ \017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027\026\022\024\r\024\005 \004\026\f\021\024\021\024\005. )Tj 0.003 Tw T* [(\217\026\035\017\004\017\016 )0.5(\002\t\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.5(I )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 17.176 0 Td [(III )0.5(\f\021\036\023\036\027\017. )]TJ 0.095 Tw -17.176 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\020\024 \f\023\024\f\024\002\026 \023\035\026\f\021\017\022\017 \023\ \030\036)Tj 0 Tw (-)Tj 0.273 Tw T* (\024\002\035\026\007\026\035\017 \024\f\035\024\032\027\036\027\017\016 \ I \f\021\036\023\036\027\017, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \030\026\r\017)Tj 0 Tw (-)Tj 0.088 Tw T* (\021\017\016 \024\f\035\024\032\027\036\027\017\005 IIIa-IIIb \002\t\035\ \026 \027\036\f\022\024\035\034\022\024 \027\017\032\036, \004\036\n )Tj 0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\030\024\f\021\024\020\024 \031\001\017\r\ \026\027\017\016 \030\026\027\t \017\035\017 \023\035\026\f\021\017\022\017\ \f\036\021)Tj 0 Tw (-)Tj T* (\004\026\021\t\n \220\027\007\024\023\030\024\021\036\024\n \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj /T1_3 1 Tf 1.651 Tw 23.244 18.267 Td (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\002\r \212\006\r\206\013\ \004\b\t\r \212\004\204\t\r\b\003\004 )Tj 0 Tw T* ()Tj /Span<>> BDC ( )Tj EMC (\217\003\004\204\t\002\b\004\006\r)Tj /T1_1 1 Tf 1.156 Tw T* (\210\002\013\017\005 \022\024\005\022\024-\007\036\027\034 \(14,5[13;17]\ ; 15,5[14;20]; )Tj 0 Tw T* (15[13;20], )Tj /T1_2 1 Tf 4.516 0 Td (p)Tj /T1_1 1 Tf 0.047 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\), \021\026\022\032\036, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )Tj 0.312 Tw -4.516 -1.218 Td (\023\030\036\002\t\r\026\027\017\016 \023\026\006\017\036\027\021\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\027\024\005 \022\024\005\022\036 \023\ \024)Tj 0 Tw (-)Tj 0.281 Tw T* [(\f\035\036 \024\023\036\030\026\006\017\017 )0.5(\(11,5[10;14]; 13[11;15]; )0.5(12,5[10;16], )]TJ /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.258 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,20\) \027\036 \017\n\036\035\017 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \024\021\035\017)Tj 0 Tw (-)Tj 0.362 Tw T* (\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\005 \023\035\026\f\021\017\022\017, \023\030\024)Tj 0 Tw (-)Tj 0.167 Tw T* (\f\021\024\020\024 \031\001\017\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\017 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024\021\036\024\n )Tj 0 Tw T* (\(\f\024\024\021\r\036\021\f\021\r\036\027\027\024\).)Tj /T1_3 1 Tf 0.013 Tw 0 -2.436 TD (\200\002\213\240\b\t\r \002\217\f\002\202\b\r\b\t\235 \213\004\202\t\f\r\ \b\t\235 \212\006\002\214\r\202\b\002\217\003\b\002\005 )Tj 0 Tw 0 -1.218 TD (\006\004\b\013)Tj /T1_1 1 Tf 0.418 Tw T* (\215\024\007\027\017\036 \024\f\035\024\032\027\036\027\017\016 \f\024 \ \f\021\024\030\024\027\t \023\030\024\n\036\032\027\024\f\021\027\024\005\ )Tj 0.022 Tw T* (\030\026\027\t \030\026\r\017\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (2% \(1/50\) \023\026\006\017\036\027\021\024\r \020\030\031\023\023\t \027\ \024\r\024)Tj 0 Tw (-)Tj 0.117 Tw T* [(\020\024 )0.5(\f\023\024\f\024\002\026 )0.6(\023\035\026\f\021\017\022\017, )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.995 0 Td [(14% )0.5(\(7/50\) )0.6(\020\030\031\023\023\t )0.5(\023\030\024\f\021\024\020\024 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \031\006\027\025\n\022 \022\025\023\ \027\025\024\022\021\025\031\024\023\022 \240\031\f\027\021\031\b\031 \024\ \022\025\030\032\031\026\020 \021)Tj /Span<>> BDC ( )Tj EMC 29.115 0 Td (\b\032\r\033\033\020\200 \024\032\020\021\025\027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw -29.115 -1.2 Td [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.318 0 Td [( R)2.8(e)-22(s)6.7(u)-1.5(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-6.3(i)3.9(n s)-14.7(y)-4.8(n)-4.8(d)0.8(r)-2(o)-4(m)-5.3(e i)4(n)-0.6(t)-1.6(e)-7(n)3.7(s)-12.5(i)-3.4(t)-33.8(y a)-7.2(s)-10.5(s)0.5(e)-22(s)-10.4(s)5.1(m)-5.3(e)-7(n)-0.6(t i)3.9(n c)2.8(o)-3.9(m)-1(p)-6.3(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.3(u)-2.3(p)1.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 261.0374 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 317.7303 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 374.4232 715.181 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.124 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 684.5118 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 684.5118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 684.5118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 684.5118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 684.5118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 663.4426 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 663.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 663.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 663.4426 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 663.4426 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 642.3734 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 642.3734 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 642.3734 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 642.3734 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 642.3734 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 621.3041 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 621.3041 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 621.3041 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 621.3041 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 621.3041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 600.2349 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 261.0374 600.2349 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 600.2349 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 374.4232 600.2349 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 448.124 600.2349 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 130.5078 696.9465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 18.526 1.2 Td (\025\002\004\235 )Tj -0.633 -1.2 Td (\212\f\004\217\003\t\220\004)Tj /T1_4 1 Tf 0.641 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.638 2.4 Td (\200\006\002\217\003\002\r )Tj -0.414 -1.2 Td (\210\230\t\004\b\t\r)Tj /T1_4 1 Tf 0.863 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 5.319 2.4 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_4 1 Tf 1.724 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_4 1 Tf 6.333 1.2 Td (\t)Tj /T1_3 1 Tf (-\213\b\004\201\r\b\t\r)Tj /T1_4 1 Tf 4.664 0 0 4.664 490.6943 699.6105 Tm (\001)Tj /T1_3 1 Tf 8 0 0 8 45.6044 675.8773 Tm (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 1-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf 0 -1.2 TD (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0;5,0\))Tj 7.087 0 Td (6,0)Tj /Span<>> BDC ( )Tj EMC (\(6,0;7,0\))Tj 8.15 0 Td (6,0)Tj /Span<>> BDC ( )Tj EMC (\(5,0;7,0\))Tj 8.945 1.2 Td (0,005)Tj /T1_3 1 Tf -52.234 -2.635 Td (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 3-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0;5,0\))Tj 7.087 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(5,0;6,0\))Tj 8.15 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0;5,0\))Tj 8.945 1.2 Td (0,002)Tj /T1_3 1 Tf -52.234 -2.635 Td (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 5-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0;4,0\))Tj 7.087 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0;4,0\))Tj 8.15 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0;4,0\))Tj 8.695 1.2 Td (0,0007)Tj /T1_3 1 Tf -51.984 -2.635 Td (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 7-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (1,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0;2,0\))Tj 7.087 0 Td (2,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0;2,0\))Tj 8.15 0 Td (1,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0;2,0\))Tj 9.195 1.2 Td (0,08)Tj /T1_2 1 Tf 7 0 0 7 42.5197 588.7503 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 569.4464 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \206\020\025\025\022\027 \033\031\024\f\027\031\033\027\032\020\006\022\ \031\025\025\013\027 \031\024\f\031\255\025\027\025\022\t \033\032\031\026\ \027\255\025\031\024\023\025\031\235 \032\020\025)0.5(\013 \r)]TJ /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \b\032\r\033\033 \024\032\020\021\025\ \027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( E)18(a)-4.2(r)-10.1(l)6.7(y p)-9.1(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.1(t)-29.1(i)-2.9(v)2.3(e c)2.8(o)-4(m)-1(p)-4.9(li)-1.7(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-11.2(e)-6(r)-39(i)3.9(n)-2.4(e)-7.5(a)-4.5(l w)2.3(o)-3.4(u)0.6(n)-4.8(d i)3.9(n p)-6.3(a)-9.2(t)-29(i)-1.4(e)-7(n)-0.6(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-3.9(m)-1(p)-6.3(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.3(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 554.1444 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 261.0374 554.1444 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 317.7303 554.1444 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 374.4232 554.1444 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.1241 554.1444 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 523.4752 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 261.0374 523.4752 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 317.7303 523.4752 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 374.4232 523.4752 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 448.1241 523.4752 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 496.313 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 42.5197 454.406 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 261.0374 454.406 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 317.7303 454.406 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 374.4232 454.406 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 448.1241 454.406 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 496.313 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 42.5197 366.1367 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 261.0374 366.1367 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 317.7303 366.1367 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 374.4232 366.1367 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 448.1241 366.1367 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 496.313 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 42.5197 297.0675 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 261.0374 297.0675 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 297.0675 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 374.4232 297.0675 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 448.1241 297.0675 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 130.5078 535.9099 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 18.526 1.2 Td (\025\002\004\235 )Tj -0.633 -1.2 Td (\212\f\004\217\003\t\220\004)Tj /T1_4 1 Tf 0.641 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.638 2.4 Td (\200\006\002\217\003\002\r )Tj -0.414 -1.2 Td (\210\230\t\004\b\t\r)Tj /T1_4 1 Tf 0.863 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 5.319 2.4 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_4 1 Tf 1.724 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_4 1 Tf 6.484 1.2 Td (\t)Tj /T1_3 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (\017\217\f\002\202\b\r\b\t\235 \212\006\002\214\r\202\b\002\217\003\b\002\ \005 \006\004\b\013)Tj /T1_1 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj 0 -1.2 TD (\f\036\030\024\n\026)Tj T* (\020\036\n\026\021\024\n\026)Tj T* (\027\026\020\027\024\036\027\017\036)Tj T* (\027\036\022\030\024 \035\024\f\022\031\021\026 \002\036 \030\026\f\b\024\ \032\007\036\027\017\016 \022\030\026\036\r \030\026\027\t)Tj T* (\027\036\022\030\024 \035\024\f\022\031\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\b\024\032\007\036\027\017\036\n \022\030\026\036\r \030\026\027\ \t)Tj 27.543 6.001 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(84%\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 6.587 6 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(68%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.25 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj -0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 1.366 -1.2 Td (0)Tj T* (0)Tj 6.534 6 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(76%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj -0.25 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 1.366 -1.2 Td (0)Tj T* (0)Tj 7.026 7.2 Td (0,43)Tj /T1_3 1 Tf -52.484 -8.635 Td (\017\217\f\002\202\b\r\b\t\235, \b\r \217\235\213\004\b\b\013\r \217)Tj /Span<>> BDC ( )Tj EMC (\212\006\002\214\r\202\b\002\217\003\b\002\005 \006\004\b\002\005)Tj /T1_1 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj T* (\007\017\f\235\031\027\022\006\017\016 \n\024\004\036\r\024\020\024 \023\ \031\t\030\016)Tj T* (\022\030\024\r\024\021\036\004\036\027\017\036 \r\027\031\021\030\017\002\ \030\033\001\027\024\036)Tj T* (\022\017\001\036\004\027\026\016 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\034)Tj T* (\027\026\020\027\024\036\027\017\036 \035\026\023\026\030\024\021\024\n\027\ \024\005 \030\026\027\t)Tj T* (\220\r\036\027\021\030\026\006\017\016)Tj 0 -1.2 TD (\023\026\030\026\f\021\024\n\026\035\034\027\t\036 \024\f\035\024\032\027\ \036\027\017\016)Tj 0 -1.2 TD (\023\027\036\r\n\024\027\017\016)Tj 27.543 8.401 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(90%\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 1.116 -1.2 Td (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 1.116 -1.2 Td (0)Tj 0 -1.2 TD (0)Tj 0 -1.2 TD (0)Tj 5.471 8.4 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 1.616 -1.2 Td (0)Tj -1.116 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 1.116 -1.2 Td (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 7.65 8.4 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 1.116 -1.2 Td (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 1.116 -1.2 Td (0)Tj T* (0)Tj 7.026 9.6 Td (0,42)Tj /T1_3 1 Tf -52.484 -11.035 Td (\020\235\202\r\217\003\001 \002\217\f\002\202\b\r\b\t\005 \212\002)Tj /Span<>> BDC ( )Tj EMC (Clavien-Dindo)Tj /T1_1 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj T* (I \f\021\036\023\036\027\034)Tj T* (II \f\021\036\023\036\027\034)Tj T* (IIIa \f\021\036\023\036\027\034)Tj T* (IIIb \f\021\036\023\036\027\034)Tj T* (IVa \f\021\036\023\036\027\034)Tj 28.043 6.001 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj -0.5 -1.2 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(44%\))Tj 0 -1.2 TD (16)Tj /Span<>> BDC ( )Tj EMC (\(32%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 0 -1.2 TD (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 7.087 6 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj -0.5 -1.2 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(26%\))Tj 0 -1.2 TD (21)Tj /Span<>> BDC ( )Tj EMC (\(42%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 0 -1.2 TD (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.25 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 8.15 6 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj -0.5 -1.2 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(34%\))Tj 0 -1.2 TD (16)Tj /Span<>> BDC ( )Tj EMC (\(32%\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 0 -1.2 TD (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.142 7.2 Td (0,64)Tj /T1_2 1 Tf 7 0 0 7 42.5197 285.5829 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC (\227 \n\032\022\023\027\032\022\235 \250)Tj 4.081 0 0 4.081 128.4152 287.9139 Tm (2)Tj 7 0 0 7 130.4557 285.5829 Tm ( \004\022\032\024\031\025\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.9144 56.0378 Tm (87)Tj ET endstream endobj 1100 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.02 Tw 10 0 0 10 70.8661 201.1759 Tm [(\022\004\b\b\t\r )0.6(\212\002\217\f\r\002\212\r\006\004\204\t\002\b\b\013\r )0.6(\002\217\f\002\202\b\r\b\t\235 )0.5(\212\006\002\214\r\202)]TJ 0 Tw (-)Tj 0 -1.218 TD (\b\002\217\003\b\002\005 \006\004\b\013)Tj /T1_1 1 Tf 0.463 Tw T* [(\200 )0.5(\006\036\035\024\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.812 0 Td [(\030\026\027\027\036\n )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036 )]TJ 0.096 Tw -5.812 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\f\023\024\035\034\024\r\026\027\017\016 \027\ \024\r\024\005 \023\035\026\f\021\017\022\017 \004\026\f\021\024\021\026\ \024\f)Tj 0 Tw (-)Tj 0.055 Tw 0 -1.218 TD (\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\017\035\026 24% \(12\ /50\), \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\f\021\024\020\024 )Tj 0.043 Tw 0 -1.218 TD (\031\001\017\r\026\027\017\016 \030\026\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 32% \(16/50\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \023\030\017\n\036\027\036)Tj 0 Tw (-)Tj 0.034 Tw 0 -1.218 TD (\027\017\016 \f\036\021\004\026\021\024\020\024 \220\027\007\024\023\030\ \024\021\036\026)Tj /Span<>> BDC ( )Tj EMC (\227 28% \(14/50\), \023\024\035\031\004\036\027)Tj 0 Tw (-)Tj 0.164 Tw 0 -1.218 TD (\027\t\036 \030\026\035\017\004\017\016 \027\036 \017\n\036\035\017 \f\021\ \026\021\017\f\021\017\004\036\f\022\024\005 \027\026\004\017\n\024\f\021\ \017 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,67\).)Tj 0.03 Tc 0.401 Tw 0 -1.218 TD (\200 \030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\n \023\036\030\017\024\007\036 \024\f\035\024\032)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.109 Tw 0 -1.218 TD (\027\036\027\017\016 \f\024 \f\021\024\030\024\027\t \023\030\024\n\036\032\ \027\024\f\021\027\024\005 \030\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036)30( )]TJ 0.113 Tw 23.244 12.178 Td (\027\024\r\024\005 \023\035\026\f\021\017\022\017 \030\026\r\017\035\017\ \f\034 \031)Tj /Span<>> BDC ( )Tj EMC [(16% )0.5(\(8/50\) \023\026\006\017\036\027)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc -0.037 Tw 0 -1.218 TD (\021\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\f\021\024\020\024 \031\001\017\r\026\ \027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC [(32% \(16/50\),)30( )]TJ 0.006 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\035\026\f\021\017\022\017 \f\036\021\004\026\ \021\t\n \220\027\007\024\023\030\024\021\036\024\n)Tj /Span<>> BDC ( )Tj EMC [(\227 24%)30( )]TJ 0.146 Tw 0 -1.218 TD (\(12/50\), \()Tj /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.03 Tc 0.146 Tw /Span<>> BDC 4.925 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,17\). \213\f\035\017 \007\036\021\026\035\017\017\030\024\r\026\021\034\ \030\026\027\027\017\036)30( )]TJ 0.148 Tw -4.925 -1.218 Td [(\024\f\035\024\032\027\036\027\017\016, )0.5(\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.346 0 Td [(\023\030\017\n\036\027\036\027\017\017 )0.5(\027\024\r\024\020\024 )0.5(\f\023\024\f\024\002\026)30( )]TJ -0.003 Tw -9.346 -1.218 Td (\023\035\026\f\021\017\022\017 \027\036\f\022\024\035\034\022\024 \030\036\ \032\036 \r\024\027\017\022\026\035\017 \f\036\030\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC 20.724 0 Td (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.268 Tw -20.724 -1.218 Td (\020\027\024\036\027\017\036 \030\026\027\t. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\017)30( )]TJ 0.023 Tw 0 -1.218 TD (\027\024\r\024\005 \023\035\026\f\021\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \027\026\002\035\033\007\036\027\017\016\b \030\026\r\017\035\ \f\016 \027\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.06 Tw 0 -1.218 TD (\022\030\024 \022\030\026\036\r \035\024\f\022\031\021\026 \(\r \024\007\ \027\024\n \017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\017\b \027\026\002\035\033\007\036\027\017\005)30( )]TJ 0.153 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\f\b\024\032\007\036\027\017\036\n \022\030\026\036\r \023\024\f\ \035\036\024\023\036\030\026\006\017\024\027\027\024\005 \030\026\027\t)30( )]TJ 0 Tw 0 -1.218 TD (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\240\212\020\t \200\020\032\020\n\023\027\032\022\024\023\022\n\020\ \033\020\006\022\027\025\023\031\021 \b\032\r\033\033 \024\032\020\021\025\ \027\025\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (\032\027\016\r\f\017\023\020\023\020\026 \004\216\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( G)-5.7(e)-7(n)-2.4(e)-6(r)3.4(a)-4.5(l c)-2.5(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.5(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-6.2(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.9(s a)-9.2(c)2.3(c)2.8(o)-3(r)-3(d)-3(i)3.9(n)-0.6(g t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e r)-2(e)-22(s)6.8(u)-1.6(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e P)22.6(H)14.9(I)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.9351 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 684.5118 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.9351 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 684.5118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 663.4425 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 663.4425 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 663.4425 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.9351 663.4425 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 663.4425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 642.3733 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 642.3733 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 642.3733 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.9351 642.3733 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 642.3733 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 621.3041 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 621.3041 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 621.3041 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 621.3041 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 621.3041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 609.8349 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 609.8349 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 609.8349 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 609.8349 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 609.8349 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 598.3657 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 598.3657 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 598.3657 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 598.3657 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 598.3657 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 586.8964 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 586.8964 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 586.8964 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 586.8964 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 586.8964 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 575.4272 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 246.8642 575.4272 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 323.3996 575.4272 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 399.9351 575.4272 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 476.4705 575.4272 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 524.6594 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 535.158 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 535.158 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 535.158 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.9351 535.158 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 535.158 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 504.4888 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 246.8642 504.4888 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 323.3996 504.4888 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 399.9351 504.4888 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 476.4705 504.4888 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 524.6594 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 464.2196 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 246.8642 464.2196 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 323.3996 464.2196 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 399.9351 464.2196 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 476.4705 464.2196 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 524.6594 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 70.8661 404.7504 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 404.7504 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 404.7504 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 404.7504 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 404.7504 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 393.2811 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 393.2811 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 393.2811 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 393.2811 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 476.4705 393.2811 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_0 1 Tf 8 0 0 8 137.5944 696.9465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.025 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_3 1 Tf 2.091 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.813 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_3 1 Tf 2.754 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.736 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_3 1 Tf 1.724 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_3 1 Tf 6.661 1.2 Td (\t)Tj /T1_0 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (\225\t\006\210\006\n\t\201\r\217\220\t\005 \220\f\t\006\r\b\217)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.256 0.001 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(10;14\))Tj 9.567 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(10;15\))Tj 9.567 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(10;13\))Tj 9.095 1.2 Td (0,96)Tj /T1_0 1 Tf -52.484 -2.635 Td (\021\002\f\t\201\r\217\003\002 \t\217\217\f\r\240\002\004\b\b\013\216 \ \f\t\214\226\002\210\213\f\002)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.256 0.001 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(12;16\))Tj 9.567 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(12;16\))Tj 9.567 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(13;16\))Tj 9.095 1.2 Td (0,05)Tj /T1_0 1 Tf -52.484 -2.635 Td (\021\002\f\t\201\r\217\003\002 \212\002\006\004\202\r\b\b\013\216 \f\t\214\ \226\002\210\213\f\002)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.663 0.001 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;1,1\))Tj 9.909 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;0\))Tj 9.567 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;2\))Tj 8.345 1.2 Td (0,88)Tj /T1_0 1 Tf -52.484 -2.635 Td (\017\212\210\216\002\f\r\013\r \240\r\212\002\213\t\003\013)Tj /T1_1 1 Tf 24.782 0.001 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.567 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.567 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 8.569 0 Td (0,79)Tj /T1_0 1 Tf -52.484 -1.435 Td (\231\220\217\003\004\214\210\006\004\f\001\b\004\235 \r\b\002\213\b\004\ \235 \t\b\004\213\t\235)Tj /T1_1 1 Tf 25.032 0.001 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.567 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 9.567 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 8.319 0 Td (0,55)Tj /T1_0 1 Tf -52.484 -1.435 Td (\035\t\214\226\002\004\217\220\210\f\235\006\b\004\235 \t\b\004\213\t\235\ )Tj /T1_1 1 Tf 24.782 0.001 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 9.567 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.317 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 8.819 0 Td (0,31)Tj /T1_0 1 Tf -52.484 -1.435 Td (\200\r\006\t\b\r\006\004\f\001\b\013\005 \006\002\217\003)Tj /T1_1 1 Tf 24.782 0.001 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 9.567 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 9.567 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 8.569 0 Td (0,61)Tj /T1_0 1 Tf -52.484 -1.435 Td (\037\r\f\002\217\003\b\002\217\003\001 \214\r\213\002\006\r\220\003\004\f\ \001\b\002\005 \226\004\217\204\t\t)Tj /T1_1 1 Tf 1.063 -1.2 Td (\n\t\001\036\004\027\t\005 \f\035\024\005 \(G1\))Tj T* (\017\027\021\030\026\n\036\024\030\036\022\021\026\035\034\027\024 \(G2\ \))Tj T* (\n\036\024\030\036\022\021\026\035\034\027\026\016 \235\026\f\006\017\016\ \(G3\))Tj 23.719 2.401 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj -0.25 -1.2 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(62%\))Tj T* (10)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 9.567 2.4 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(34%\))Tj 0 -1.2 TD (29)Tj /Span<>> BDC ( )Tj EMC (\(58%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 9.317 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj -0.25 -1.2 Td (37)Tj /Span<>> BDC ( )Tj EMC (\(74%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 8.569 3.6 Td (0,04)Tj /T1_0 1 Tf -52.484 -5.035 Td (\027\t\217\003\002\f\002\n\t\201\r\217\220\002\r \217\003\006\002\r\b\t\r\ )Tj /T1_1 1 Tf 1.063 -1.2 Td (\026\007\036\027\024\022\026\030\006\017\027\024\n\026)Tj 0 -1.2 TD (\026\007\036\027\024\022\026\030\006\017\027\024\n\026 \f\035\017\017\f\ \021\026\016)Tj 23.219 1.201 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1.866 -1.2 Td (0)Tj 7.701 1.2 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1.866 -1.2 Td (0)Tj 7.951 1.2 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(96%\))Tj 0.5 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 8.319 2.4 Td (0,13)Tj /T1_0 1 Tf -52.484 -3.835 Td (\031\t\226\226\r\006\r\b\204\t\006\002\220\004 \002\212\210\216\002\f\t\ )Tj /T1_1 1 Tf 1.063 -1.2 Td (G1)Tj 0 -1.2 TD (G2)Tj 0 -1.2 TD (G3)Tj 23.469 2.401 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 0 -1.2 TD (31)Tj /Span<>> BDC ( )Tj EMC (\(62%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.317 2.4 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(28%\))Tj T* (30)Tj /Span<>> BDC ( )Tj EMC (\(60%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.317 2.4 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj T* (34)Tj /Span<>> BDC ( )Tj EMC (\(68%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 8.319 3.6 Td (0,86)Tj /T1_0 1 Tf -52.484 -5.035 Td (\026\f\t\235\b\t\r \b\r\002\004\240\233\211\004\b\003\b\002\n\002 \f\r\201\ \r\b\t\235)Tj /T1_1 1 Tf 1.063 -1.2 Td (TRG 0 \(\023\024\035\027\t\005 \024\021\r\036\021\))Tj T* (TRG 1 \(\023\024\004\021\017 \023\024\035\027\t\005 \024\021\r\036\021\)\ )Tj T* (TRG 2 \(\004\026\f\021\017\004\027\t\005 \024\021\r\036\021\))Tj T* (TRG 3 \(\027\036\021 \024\021\r\036\021\026\))Tj T* (\027\036 \023\030\024\r\024\007\017\035\024\f\034)Tj 23.969 4.801 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3%\))Tj -0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj -0.25 -1.2 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(60%\))Tj 0.25 -1.2 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj 0.25 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 9.567 4.8 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj -0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj -0.25 -1.2 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj T* (14)Tj /Span<>> BDC ( )Tj EMC (\(28%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.567 4.8 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj -0.5 -1.2 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(22%\))Tj 0 -1.2 TD (24)Tj /Span<>> BDC ( )Tj EMC (\(48%\))Tj 0 -1.2 TD (12)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.319 6 Td (0,77)Tj /T1_0 1 Tf -52.484 -7.435 Td (\200\r\006\226\002\006\004\204\t\235 \002\212\210\216\002\f\t)Tj /T1_1 1 Tf 25.032 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 9.317 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 9.567 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 8.569 0 Td (0,46)Tj /T1_2 1 Tf 7 0 0 7 70.8661 381.7966 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020 \030\f\t \n\031\f\022\007\027\024\023\021\027\025\025\ \013\200 \033\031\n\020\016\020)49.3(\023\027\f\027\235; \n\032\022\023\027\032\022\235 \250)]TJ 4.081 0 0 4.081 344.0359 384.1276 Tm (2)Tj 7 0 0 7 346.0763 381.7966 Tm [( \004\022\032\024\031\025\020 \030\f\t \n\020\007\027\024\023\021\027\025\ \025\013\200 \033\031\n\020\016\020)49(\023\027\f\027\235)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 362.4926 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\031\n\020\016\020\023\027\f\022 \033\032\031\030\031\f\255\022\023\ \027\f\017\025\031\024\023\022 \031\033\027\032\020\023\022\021\025\031\b\ \031 \021\026\027\213\020\023\027\f\017\024\023\021\020 \022)Tj /Span<>> BDC ( )Tj EMC (\031\240\236\027\026\020 \n\032\031\021\031\033\031\023\027\032\022 \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 \024\032\020\021\025\027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( I)2.2(n)-4.8(d)-3(i)-1.7(c)3.2(a)-9.2(t)-3(o)-3(r)-14.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e d)0.8(u)1.6(r)3.3(a)-9.2(t)-29.1(i)-1.3(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)6.7(u)1.6(r)-2(g)-6.8(e)-6(r)-43.7(y a)-5.1(n)-4.8(d t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(v)3.3(o)-5.3(lu)0.6(m)-5.3(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(b)-3.3(l)-1.6(o)-12(o)-12(d l)-1.6(o)-1(s)-10.5(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-3.9(m)-1(p)-6.3(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.3(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 70.8661 347.1907 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 347.1907 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 347.1907 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.935 347.1907 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 347.1907 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 316.5215 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 316.5215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 316.5215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.935 316.5215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 316.5215 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 295.4522 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 295.4522 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 295.4522 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.935 295.4522 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 295.4522 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 264.783 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 264.783 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 264.783 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.935 264.783 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 264.783 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 243.7138 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 243.7138 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 243.7138 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 243.7138 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 476.4705 243.7138 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_0 1 Tf 8 0 0 8 137.5944 328.9561 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.025 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_3 1 Tf 2.091 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.813 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_3 1 Tf 2.754 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.736 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_3 1 Tf 1.724 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_3 1 Tf 6.51 1.2 Td (\t)Tj /T1_0 1 Tf (-\213\b\004\201\r\b\t\r)Tj /T1_3 1 Tf 4.664 0 0 4.664 519.0408 331.6201 Tm (\001)Tj /T1_0 1 Tf 8 0 0 8 73.9508 307.8869 Tm (\017\206\227\r\r \006\r\214\235 \002\212\r\006\004\204\t\t, )Tj /T1_2 1 Tf (\026\022\025\r\023)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 23.506 0.001 Td (180)Tj /Span<>> BDC ( )Tj EMC (\(180;205\))Tj 9.567 0 Td (170)Tj /Span<>> BDC ( )Tj EMC (\(140;210\))Tj 9.567 0 Td (180)Tj /Span<>> BDC ( )Tj EMC (\(155;200\))Tj 9.845 1.2 Td (0,05)Tj /T1_0 1 Tf -52.484 -2.635 Td (\200\006\002\240\002\f\202\t\003\r\f\001\b\002\217\003\001 \234\003\004\212\ \004 \212\f\004\217\003\t\220\t )Tj T* (\212\006\002\214\r\202\b\002\217\003\b\002\005 \006\004\b\013, )Tj /T1_2 1 Tf (\026\022\025\r\023)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.256 0.001 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(45;55\))Tj 9.567 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(20;25\))Tj 9.567 0 Td (35)Tj /Span<>> BDC ( )Tj EMC (\(30;40\))Tj 8.228 2.4 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_0 1 Tf -51.618 -3.835 Td (\017\206\233\r\214 \220\006\002\002\212\002\003\r\006\t, )Tj /T1_2 1 Tf (\026\f)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 23.506 0.001 Td (100)Tj /Span<>> BDC ( )Tj EMC (\(100;200\))Tj 9.567 0 Td (150)Tj /Span<>> BDC ( )Tj EMC (\(100;210\))Tj 9.567 0 Td (150)Tj /Span<>> BDC ( )Tj EMC (\(100;200\))Tj 9.845 1.2 Td (0,30)Tj /T1_2 1 Tf 7 0 0 7 70.8661 232.2292 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (86)Tj ET endstream endobj 972 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 973 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 974 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 975 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 976 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1157 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.668 Tw 10 0 0 10 42.5197 724.8299 Tm [(\f\r\016\022\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.608 0 Td [(\022\030\036\f\021\006\024\r\024-\022\024\023\004\017\022\024\r\t\n )0.6(\f\024\004\035\036\027\036\027\017\036\n\), )]TJ 0.113 Tw -5.608 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \021\030\036\021\017 \022\030\036\f\021\006\024\ \r\024-\002\031\020\024\030\027\024\005 \f\r\016\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\002)Tj 0 Tw (-)Tj 0.159 Tw 0 -1.218 TD (\035\026\f\021\017 \f\036\007\026\035\017\013\027\024\020\024 \002\031\020\ \030\026 \(\022\024\027\036\004\027\t\005 \031\004\026\f\021\024\022 \022\ \030\036\f\021)Tj 0 Tw (-)Tj 0.244 Tw T* (\006\024\r\024-\002\031\020\024\030\027\024\005 \f\r\016\022\017\). \212\ \024\023\024\035\027\017\021\036\035\034\027\024 \f\036\021\022\031 \235\ \017\022)Tj 0 Tw (-)Tj 0.089 Tw T* (\f\017\030\024\r\026\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\n\016\020\022\017\n \021\022\026\027\016\n \n\036\032\007\031 \024\023\017\ \f\026\027\027\t\n\017 \r\t\001\036 )Tj 0 Tw T* (\001\r\026\n\017.)Tj /T1_2 1 Tf 0 -2.436 TD (\017\204\r\b\t\004\r\214\013\r \212\004\006\004\214\r\003\006\013)Tj /T1_3 1 Tf 0 -1.218 TD (\002\025\023\032\020\031\033\027\032\020\006\022\031\025\025\013\027:)Tj /T1_1 1 Tf 0.898 Tw ( \024\002\013\026\016 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\034 )Tj 0.245 Tw T* (\024\023\036\030\026\006\017\017, \023\030\024\007\024\035\032\017\021\036\ \035\034\027\024\f\021\034 \220\021\026\023\026 \023\035\026\f\021\017\022\ \017 \023\030\024)Tj 0 Tw (-)Tj 1.06 Tw T* (\n\036\032\027\024\f\021\027\024\005 \030\026\027\t, \024\002\255\201\n \ \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 )Tj 0 Tw 0 -1.218 TD (\022\030\024\r\024\023\024\021\036\030\017.)Tj /T1_3 1 Tf 0.226 Tw 0 -1.218 TD [(\206\020\025\025\022\235 )0.5(\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\013\235 )0.7(\033\027\032\022\031\030 )0.5(\(\030\031 )0.5(30 )0.5(\024\r\023\031\n\):)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.068 Tw 0 -1.218 TD (\017\027\021\036\027\f\017\r\027\024\f\021\034 \002\024\035\036\r\024\020\ \024 \f\017\027\007\030\024\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\024\r\024\005 \030\036\005)Tj 0 Tw (-)Tj 0.155 Tw 0 -1.218 TD (\021\017\027\020\024\r\024\005 \001\022\026\035\036 \(NRS\) \027\026)Tj /Span<>> BDC ( )Tj EMC (1, 3, 5, 7-\036 \f\031\021\022\017; \004\026\f\021\024\021\026 )Tj 0.076 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\026 \024\f\035\024\032\027\036\027\017\005\ \f\024 \f\021\024\030\024\027\t \023\030\024\n\036\032\027\024\f\021\027\ \024\005 )Tj 0.097 Tw 0 -1.218 TD (\030\026\027\t \(\f\036\030\024\n\026, \020\036\n\026\021\024\n\026, \027\ \026\020\027\024\036\027\017\036, \027\036\022\030\024 \035\024\f\022\031\ \021\026\) )Tj 0.104 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\b \024\f\035\024\032\027\036\027\017\005; \021\016\032\036\ \f\021\034 \024\f\035\024\032\027\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f)Tj 0 Tw (-)Tj 1.346 Tw 0 -1.218 TD [(\f\017\235\017\022\026\006\017\017 Cl)-16(av)-16(ien\226Dind)-15.9(o; \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )]TJ 0 Tw 0 -1.218 TD (\020\024\f\023\017\021\026\035\017\026\006\017\017.)Tj /T1_3 1 Tf 0.245 Tw T* (\217\023\030\020\f\233\025\025\013\235 \033\027\032\022\031\030 \(\026\027\ \030\022\020\025\020 14 \026\027\024\t\006\027\021\):)Tj /T1_1 1 Tf ( \004\026\f\021\024)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD [(\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.036 0 Td [(\f\021\030\031\022\021\031\030\026 )0.5(\023\024\007\027\017\b )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\023\030\024\n\036\032\027\024\f\021\027\024\005 )]TJ 0.07 Tw -2.036 -1.218 Td (\030\026\027\t \(\f\r\017\013\017, \026\002\f\006\036\f\f\t, \023\030\024\ \n\036\032\027\024\f\021\027\t\036 \020\030\t\032\017, \b\030\024)Tj 0 Tw (-)Tj 0.047 Tw 0 -1.218 TD (\027\017\004\036\f\022\017\005 \002\024\035\036\r\024\005 \f\017\027\007\ \030\024\n\); \024\006\036\027\022\026 \022\026\004\036\f\021\r\026 \032\ \017\027\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \024\023\030\024\f\027\017\022\024\r EQ-5D-3L\ \017)Tj /Span<>> BDC ( )Tj EMC [(EQ-V)37.2(A)35(S.)]TJ /T1_4 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.241 Tw 0 -1.218 TD (\215\030\017 \024\023\030\036\007\036\035\036\027\017\017 \024\002\255\036\ \n\026 \r\t\002\024\030\022\017 \017\f\023\024\035\034\024\r\026\035\017\ \f\034 )Tj 0.349 Tw 0 -1.218 TD (\017\n\036\033\013\017\036\f\016 \007\026\027\027\t\036 \023\024\023\031\ \035\016\006\017\024\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ , )Tj 0.242 Tw 0 -1.218 TD (\017\031\004\026\033\013\017\b \004\026\f\021\024\021\031 \030\026\r\017\ \021\017\016 \023\030\024\n\036\032\027\024\f\021\027\t\b \020\030\t\032\ )Tj 0.177 Tw 0 -1.218 TD ([3,14,15], \f\024\020\035\026\f\027\024 \022\024\021\024\030\t\n \220\021\ \024\021 \023\024\022\026\026\021\036\035\034 \022\024\035\036\002)Tj 0 Tw (-)Tj -0.071 Tw T* (\035\036\021\f\016 \024\021 3,3% \007\024)Tj /Span<>> BDC ( )Tj EMC (67%, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n 35%. \215\030\036\007\023\024\035\026\020\026\036\ \n\024\036 )Tj 0.393 Tw T* (\f\027\017\032\036\027\017\036 \004\026\f\021\024\021\t \r\024\027\017\022\ \027\024\r\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\027\024\005\ )Tj 0.345 Tw T* (\020\030\t\032\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 \023\035\026\f\021\017\022\017 )Tj -0.013 Tw T* (\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\020\024 \007\027\026 \f\024\f\021\026\r\035\016\036\021\ 10%.)Tj 0.813 Tw 0 -1.218 TD (\215\030\017 \030\026\f\004\036\021\036 \024\002\255\036\n\026 \r\t\002\024\ \030\022\017 \017\f\023\024\035\034\024\r\026\035\026\f\034 )Tj 0 Tw 0 -1.218 TD (\235\024\030\n\031\035\026 )Tj ET 0 0 0 0 k /GS0 gs 118.439 262.066 65.083 22.225 re f /PlacedPDF /MC0 BDC q 118.439 262.066 65.083 22.225 re W n 0 0 0 1 k q 1 0 0 1 120.2536 269.4193 cm 0 0 m -0.094 0 -0.175 0.025 -0.242 0.076 c -0.309 0.126 -0.343 0.195 -0.343 0.282 c -0.343 0.37 -0.215 0.917 0.04 1.925 c 0.296 2.933 0.43 3.481 0.444 3.568 c 0.45 3.602 0.454 3.679 0.454 3.8 c 0.454 4.062 0.373 4.193 0.212 4.193 c 0.057 4.193 -0.084 4.069 -0.212 3.82 c -0.286 3.679 -0.356 3.468 -0.423 3.185 c -0.464 3.051 -0.484 2.98 -0.484 2.974 c -0.497 2.933 -0.561 2.913 -0.675 2.913 c -0.816 2.913 l -0.857 2.953 -0.877 2.984 -0.877 3.004 c -0.877 3.031 -0.86 3.101 -0.827 3.216 c -0.625 4.008 -0.316 4.452 0.101 4.546 c 0.155 4.56 0.212 4.566 0.272 4.566 c 0.669 4.566 0.954 4.415 1.129 4.113 c 1.203 3.985 1.24 3.891 1.24 3.83 c 1.24 3.817 1.243 3.81 1.25 3.81 c 1.361 3.921 l 1.777 4.352 2.244 4.566 2.762 4.566 c 3.132 4.566 3.427 4.476 3.649 4.294 c 3.871 4.113 3.982 3.847 3.982 3.498 c 3.982 3.343 3.972 3.216 3.951 3.115 c 3.884 2.732 3.699 2.144 3.397 1.351 c 3.276 1.028 3.216 0.79 3.216 0.635 c 3.216 0.46 3.273 0.373 3.387 0.373 c 3.615 0.373 3.812 0.494 3.977 0.736 c 4.141 0.978 4.267 1.257 4.355 1.572 c 4.368 1.626 4.435 1.653 4.556 1.653 c 4.691 1.653 4.758 1.63 4.758 1.583 c 4.758 1.536 4.744 1.482 4.717 1.421 c 4.543 0.796 4.227 0.356 3.77 0.101 c 3.649 0.04 3.504 0.01 3.336 0.01 c 3.081 0.01 2.863 0.091 2.681 0.252 c 2.52 0.44 2.439 0.638 2.439 0.847 c 2.439 0.974 2.486 1.163 2.58 1.412 c 2.876 2.197 3.064 2.796 3.145 3.205 c 3.165 3.306 3.175 3.434 3.175 3.588 c 3.175 3.985 3.011 4.183 2.681 4.183 c 2.56 4.183 2.473 4.176 2.419 4.163 c 1.949 4.062 1.549 3.73 1.22 3.165 c 1.149 3.044 l 0.816 1.693 l 0.595 0.813 0.467 0.339 0.433 0.272 c 0.346 0.091 0.202 0 0 0 c f Q q 1 0 0 1 128.6019 273.028 cm 0 0 m 0 0.087 0.047 0.155 0.141 0.202 c 6.562 0.202 l 6.663 0.155 6.713 0.087 6.713 0 c 6.713 -0.074 6.666 -0.138 6.572 -0.191 c 3.367 -0.202 l 0.161 -0.202 l 0.054 -0.168 0 -0.101 0 0 c 0 -1.956 m 0 -1.855 0.054 -1.788 0.161 -1.754 c 6.572 -1.754 l 6.579 -1.761 6.594 -1.772 6.618 -1.789 c 6.641 -1.806 6.658 -1.819 6.668 -1.829 c 6.678 -1.84 6.688 -1.856 6.698 -1.88 c 6.708 -1.903 6.713 -1.929 6.713 -1.956 c 6.713 -2.043 6.663 -2.11 6.562 -2.157 c 0.141 -2.157 l 0.047 -2.11 0 -2.043 0 -1.956 c f Q q 1 0 0 1 155.5169 262.6396 cm 0 0 m -0.034 0.013 -0.05 0.037 -0.05 0.071 c -0.05 0.084 0.519 1.26 1.658 3.599 c 2.797 5.937 3.377 7.12 3.397 7.147 c 3.424 7.194 3.518 7.217 3.679 7.217 c 3.834 7.217 3.928 7.194 3.961 7.147 c 3.982 7.12 4.561 5.937 5.7 3.599 c 6.839 1.26 7.409 0.084 7.409 0.071 c 7.409 0.037 7.392 0.013 7.358 0 c h 5.836 0.917 m 5.836 0.937 5.01 2.634 3.357 6.008 c 2.98 5.248 2.564 4.402 2.107 3.468 c 0.867 0.927 l 3.347 0.917 l h f Q q 1 0 0 1 164.1786 268.6049 cm 0 0 m -0.132 0 -0.235 0.042 -0.31 0.127 c -0.385 0.211 -0.423 0.315 -0.423 0.437 c -0.423 0.776 -0.295 1.066 -0.039 1.308 c 0.217 1.55 0.524 1.671 0.881 1.671 c 1.286 1.671 1.621 1.562 1.887 1.343 c 2.152 1.124 2.315 0.839 2.377 0.487 c 2.386 0.402 2.391 0.324 2.391 0.254 c 2.391 -0.019 2.308 -0.275 2.144 -0.515 c 2.012 -0.712 1.747 -0.983 1.347 -1.326 c 1.178 -1.472 0.942 -1.688 0.642 -1.975 c 0.226 -2.369 l 0.762 -2.377 l 1.5 -2.377 1.892 -2.365 1.939 -2.341 c 1.958 -2.336 1.982 -2.287 2.01 -2.194 c 2.029 -2.141 2.061 -1.982 2.108 -1.714 c 2.108 -1.692 l 2.391 -1.692 l 2.391 -1.714 l 2.193 -3.004 l 2.193 -3.025 l -0.423 -3.025 l -0.423 -2.891 l -0.423 -2.797 -0.418 -2.743 -0.409 -2.729 c -0.404 -2.719 -0.207 -2.496 0.183 -2.059 c 0.696 -1.49 1.025 -1.114 1.17 -0.931 c 1.486 -0.503 1.643 -0.11 1.643 0.246 c 1.643 0.557 1.562 0.816 1.4 1.026 c 1.238 1.235 1.011 1.34 0.719 1.34 c 0.446 1.34 0.226 1.217 0.057 0.973 c 0.047 0.954 0.033 0.928 0.014 0.895 c 0 0.872 -0.007 0.858 -0.007 0.853 c -0.007 0.848 0.004 0.846 0.028 0.846 c 0.146 0.846 0.241 0.804 0.314 0.719 c 0.386 0.634 0.423 0.536 0.423 0.423 c 0.423 0.305 0.384 0.206 0.307 0.123 c 0.229 0.041 0.127 0 0 0 c f Q 139.745 272.719 42.84 -0.42 re f q 1 0 0 1 141.2766 275.9251 cm 0 0 m 0 -0.282 0.091 -0.423 0.272 -0.423 c 0.319 -0.423 0.36 -0.42 0.393 -0.413 c 0.729 -0.353 1.035 -0.084 1.31 0.393 c 1.378 0.501 1.438 0.625 1.492 0.766 c 1.505 0.806 1.522 0.832 1.542 0.842 c 1.562 0.852 1.613 0.857 1.693 0.857 c 1.828 0.857 1.895 0.83 1.895 0.776 c 1.895 0.763 1.882 0.722 1.855 0.655 c 1.781 0.44 1.662 0.223 1.497 0.005 c 1.332 -0.213 1.166 -0.386 0.998 -0.514 c 0.749 -0.702 0.484 -0.796 0.202 -0.796 c -0.04 -0.796 -0.247 -0.734 -0.418 -0.61 c -0.59 -0.486 -0.706 -0.323 -0.766 -0.121 c -0.78 -0.067 -0.786 0.024 -0.786 0.151 c -0.786 0.333 l -0.433 1.744 l -0.198 2.691 -0.077 3.168 -0.071 3.175 c -0.071 3.189 -0.242 3.195 -0.585 3.195 c -1.099 3.195 l -1.139 3.236 -1.161 3.263 -1.164 3.276 c -1.168 3.289 -1.159 3.347 -1.139 3.447 c -1.112 3.541 -1.095 3.592 -1.089 3.599 c -1.075 3.632 -1.043 3.651 -0.993 3.654 c -0.942 3.657 -0.773 3.659 -0.484 3.659 c 0.05 3.659 l 0.242 4.465 l 0.383 5.01 0.464 5.302 0.484 5.342 c 0.564 5.531 0.719 5.625 0.948 5.625 c 1.035 5.618 1.11 5.588 1.174 5.534 c 1.238 5.48 1.27 5.41 1.27 5.322 c 1.27 5.242 1.206 4.956 1.079 4.465 c 1.052 4.351 1.02 4.225 0.983 4.087 c 0.946 3.95 0.917 3.847 0.897 3.78 c 0.877 3.679 l 0.877 3.666 1.045 3.659 1.381 3.659 c 1.895 3.659 l 1.935 3.619 1.957 3.59 1.961 3.573 c 1.964 3.557 1.956 3.494 1.935 3.387 c 1.915 3.306 1.882 3.242 1.835 3.195 c 0.756 3.195 l 0.393 1.734 l 0.144 0.732 0.017 0.205 0.01 0.151 c 0.003 0.118 0 0.067 0 0 c f Q q 1 0 0 1 156.2542 275.5319 cm 0 0 m 0 -0.054 -0.02 -0.101 -0.06 -0.141 c -0.101 -0.181 -0.151 -0.202 -0.212 -0.202 c -0.245 -0.202 -0.319 -0.148 -0.433 -0.04 c -0.548 0.067 -0.864 0.38 -1.381 0.897 c -2.429 1.945 l -3.488 0.887 l -4.2 0.188 -4.566 -0.168 -4.586 -0.181 c -4.613 -0.195 -4.637 -0.202 -4.657 -0.202 c -4.711 -0.202 -4.759 -0.181 -4.803 -0.141 c -4.847 -0.101 -4.869 -0.054 -4.869 0 c -4.869 0.013 -4.862 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1.653 c 3.404 1.653 3.488 1.646 3.568 1.633 c 3.918 1.552 4.197 1.373 4.405 1.094 c 4.613 0.815 4.717 0.46 4.717 0.03 c 4.717 -0.286 4.654 -0.628 4.526 -0.998 c 4.358 -1.441 4.109 -1.83 3.78 -2.162 c 3.451 -2.495 3.091 -2.722 2.701 -2.843 c 2.554 -2.883 2.392 -2.903 2.218 -2.903 c 1.861 -2.903 1.583 -2.765 1.381 -2.49 c 1.331 -2.439 l 1.324 -2.446 1.25 -2.738 1.109 -3.316 c 0.968 -3.894 0.897 -4.187 0.897 -4.193 c 0.897 -4.207 0.899 -4.219 0.902 -4.229 c 0.906 -4.239 0.912 -4.247 0.922 -4.254 c 0.932 -4.26 0.942 -4.266 0.953 -4.269 c 0.963 -4.272 0.976 -4.276 0.993 -4.279 c 1.01 -4.282 1.026 -4.284 1.043 -4.284 c 1.06 -4.284 1.082 -4.286 1.109 -4.289 c 1.136 -4.292 1.159 -4.294 1.179 -4.294 c 1.26 -4.294 l 1.351 -4.294 l 1.603 -4.294 l 1.636 -4.341 1.655 -4.371 1.658 -4.385 c 1.662 -4.398 1.653 -4.459 1.633 -4.566 c 1.613 -4.647 1.593 -4.699 1.572 -4.723 c 1.552 -4.746 1.509 -4.758 1.441 -4.758 c 1.334 -4.758 1.158 -4.754 0.912 -4.748 c 0.667 -4.741 0.484 -4.738 0.363 -4.738 c -0.108 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0.127 c -0.385 0.211 -0.423 0.315 -0.423 0.437 c -0.423 0.776 -0.295 1.066 -0.039 1.308 c 0.217 1.55 0.524 1.671 0.881 1.671 c 1.286 1.671 1.621 1.562 1.887 1.343 c 2.152 1.124 2.315 0.839 2.377 0.487 c 2.386 0.402 2.391 0.324 2.391 0.254 c 2.391 -0.019 2.308 -0.275 2.144 -0.515 c 2.012 -0.712 1.747 -0.983 1.347 -1.326 c 1.178 -1.472 0.942 -1.688 0.642 -1.975 c 0.226 -2.369 l 0.762 -2.377 l 1.5 -2.377 1.892 -2.365 1.939 -2.341 c 1.958 -2.336 1.982 -2.287 2.01 -2.194 c 2.029 -2.141 2.061 -1.982 2.108 -1.714 c 2.108 -1.692 l 2.391 -1.692 l 2.391 -1.714 l 2.193 -3.004 l 2.193 -3.025 l -0.423 -3.025 l -0.423 -2.891 l -0.423 -2.797 -0.418 -2.743 -0.409 -2.729 c -0.404 -2.719 -0.207 -2.496 0.183 -2.059 c 0.696 -1.49 1.025 -1.114 1.17 -0.931 c 1.486 -0.503 1.643 -0.11 1.643 0.246 c 1.643 0.557 1.562 0.816 1.4 1.026 c 1.238 1.235 1.011 1.34 0.719 1.34 c 0.446 1.34 0.226 1.217 0.057 0.973 c 0.047 0.954 0.033 0.928 0.014 0.895 c 0 0.872 -0.007 0.858 -0.007 0.853 c -0.007 0.848 0.004 0.846 0.028 0.846 c 0.146 0.846 0.241 0.804 0.314 0.719 c 0.386 0.634 0.423 0.536 0.423 0.423 c 0.423 0.305 0.384 0.206 0.307 0.123 c 0.229 0.041 0.127 0 0 0 c f Q EMC Q BT 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 183.5229 262.0659 Tm ( ,)Tj 0.146 Tw -14.1 -1.218 Td (\030)Tj /Span<>> BDC ( )Tj EMC [(\227 \r\036\035\017\004\017\027\026 )0.5(\023\024\022\026\026\021\036\035\016 )0.5(\017\031\004\026\036\n\024\020\024 )0.5(\023\030\017\027\026\022\026, %; )]TJ 0.1 Tw 0 -1.218 TD (q)Tj /Span<>> BDC ( )Tj EMC (\227 \(100-p\); t)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\r\036\030\017\021\036\035\034\027\t\005 \022\024\220\235\235\ \017\006\017\036\027\021, \023\024)Tj 0 Tw (-)Tj 0.15 Tw T* (\022\026\t\r\026\033\013\017\005, \022\026\022\024\r\026 \r\036\030\024\ \016\021\027\024\f\021\034 \021\024\020\024, \004\021\024 \030\026\n\036\ \030\t )Tj -0.044 Tw T* [(\023\024\022\026\026\021\036\035\016 )0.5(\027\036 \002\031\007\031\021 \r\t\b\024\007\017\021\034 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\026\027\017\006\t )0.5(\023\030\036\007\036\035\034\027\024\005 )]TJ 0.126 Tw T* (\024\001\017\002\022\017 \(\024\002\t\004\027\024 t)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2, \004\021\024 \024\002\036\f\023\036\004\017\r\026\036\021 95% \r\036\030\ \024)Tj 0 Tw (-)Tj 0.104 Tw T* (\016\021\027\024\f\021\034 \002\036\024\001\017\002\024\004\027\024\020\ \024 \023\030\024\020\027\024\026\); \254)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\036\007\036\035\034\027\026\016 )Tj 0.041 Tw T* (\024\001\017\002\022\026 \023\024\022\026\026\021\036\035\016 [23]. \200\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \030\026\f\004\036\021\026 \024\002\ \255\036\n )Tj 0 Tw T* (\r\t\002\024\030\022\017 \f\024\f\021\026\r\017\035 144 \(48)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (48)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (48\) \023\026\006\017\036\027\021\026.)Tj 0.053 Tw T* [(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\024\002\030\026\002\024\021\022\026 )0.5(\007\026\027\027\t\b )0.6(\023\030\024\r\024\007\017\035\026\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.803 0 Td (\017\f)Tj 0 Tw (-)Tj -0.054 Tw -20.803 -1.218 Td [(\023\024\035\034\024\r\026\027\017\036\n )0.5(\023\026\022\036\021\026 \023\030\017\022\035\026\007\027\t\b \023\030\024\ \020\030\026\n\n S)15(t)15(a)15(t)-32(ist)-31.9(ica )]TJ 0.228 Tw T* [(13.3 \(TIBC)13(O, \222\231\202\). \212\035\016 \024\006\036\027\022\017 \030\026\f\023\030\ \036\007\036\035\036\027\017\016 \022\024)]TJ 0 Tw (-)Tj 0.576 Tw T* (\035\017\004\036\f\021\r\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005 \023\030\017\n\036\027\016\035\f\016 \022\030\017\021\036\030\017\ \005 )Tj 0.365 Tw T* [(\231\026\023\017\030\024\226\211\017\035\022\026. )0.6(\215\024\f\022\024\035\034\022\031 )0.5(\030\026\f\023\030\036\007\036\035\036\027\017\016 )0.6(\024\021\035\017\004\026)]TJ 0 Tw (-)Tj 0.064 Tw T* (\035\017\f\034 \024\021 \027\024\030\n\026\035\034\027\024\020\024, \007\ \035\016 \017\b \024\023\017\f\026\027\017\016 \017\f\023\024\035\034\024\ \r\026\035\017 )Tj 0.131 Tw T* (\n\036\007\017\026\027\031 \(Me\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\022\r\026\030\021\017\035\034\027\t\005 \030\026\n\ \026\b [Q1; Q3]. )Tj 0.152 Tw 23.244 64.543 Td (\222\030\026\r\027\036\027\017\036 \022\024\035\017\004\036\f\021\r\036\027\ \027\t\b \023\024\022\026\026\021\036\035\036\005 \n\036\032\007\031 \021\ \030\036)Tj 0 Tw (-)Tj 0.138 Tw T* (\n\016 \020\030\031\023\023\026\n\017 \023\030\024\r\024\007\017\035\024\ \f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \027\036\023\026\030\026\n\036\021\030\017)Tj 0 Tw (-)Tj 0.334 Tw T* (\004\036\f\022\024\020\024 H-\022\030\017\021\036\030\017\016 \025\030\026\ \f\022\036\035\026\226\211\024\035\035\017\f\026. \222\030\026\r\027\036\ \027\017\036 )Tj 0.02 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005 \024\f\031\013\036\f\021\r\035\016\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.055 Tw T* (\024\r\026\027\017\036\n \022\030\017\021\036\030\017\016 \245\262 \215\ \017\030\f\024\027\026. \211\030\024\r\036\027\034 \f\021\026\021\017\f\021\ \017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\005 \027\026\004\017\n\024\f\021\017 \002\t\035 \031\f\021\026\ \027\024\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 0.064 Tw T* [(\212\035\016 )0.5(\023\030\024\020\027\024\017\030\024\r\026\027\017\016 )0.6(\030\017\f\022\026 )0.5(\030\026\r\017\021\017\016 )0.6(\030\026\027\027\017\b )0.5(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.137 Tw T* (\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \002\t\035\024 \023\030\017\n\036\027\036\027\024 \027\036\005\030\ \024)Tj 0 Tw (-)Tj 0.291 Tw T* [(\f\036\021\036\r\024\036 \n\024\007\036\035\017\030\024\r\026\027\017\036\ . )0.5(\222\021\030\024\017\035\017\f\034 \n\024\007\036\035\017 \n\027\024\020\ \024)]TJ 0 Tw (-)Tj 0.045 Tw 0 -1.218 TD [(\f\035\024\005\027\024\020\024 \023\036\030\f\036\023\021\030\024\027\026\ \(Mul)56(t)-31.9(il)-16(a)15(yer)-24(ed P)30(er)-32(ceptr)-31.9(on, MLP\) )]TJ -0.005 Tw 0 -1.218 TD (\007\035\016 \002\017\027\026\030\027\t\b \006\036\035\036\r\t\b \023\036\ \030\036\n\036\027\027\t\b \253\203\026\035\017\004\017\036 \030\026\027\ \027\017\b )Tj 0.013 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005 \023\030\024\n\036\032\027\024\f\021\ \027\024\005 \030\026\027\t\273. \212\035\016 \024\006\036\027\022\017 \023\ \030\024)Tj 0 Tw (-)Tj 0.335 Tw T* [(\020\027\024\f\021\017\004\036\f\022\024\005 )0.6(\f\023\024\f\024\002\027\024\f\021\017 )0.6(\n\024\007\036\035\036\005 )0.5(\017\f\023\024\035\034\024\r\026\035\f\016 )]TJ /T1_3 1 Tf -0.019 Tc 0.019 Tw T* [(RO)-19(C)]TJ /T1_1 1 Tf 0 Tc 0 Tw 1.469 0 Td (-\026\027\026\035\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 529.9818 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 274.9606 505.6258 Tm (\225\004\006\004\220\003\r\006\t\217\003\t\220\004 \n\006\210\212\212 \217\ \006\004\b\r\b\t\235)Tj /T1_1 1 Tf 0.036 Tw T* [(\215\030\017 )0.5(\026\027\026\035\017\036 )0.6(\024\002\013\036\005 )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\020\030\031\023\023 )]TJ 0.165 Tw T* [(\f\030\026\r\027\036\027\017\016 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )0.5(\027\026\004\017\n\t\b \030\026\035\017\004\017\005 \r\t\016\r)]TJ 0 Tw (-)Tj 0.059 Tw T* (\035\036\027\024 \027\036 \002\t\035\024. \211\004\017\021\t\r\026\016, \ \004\021\024 \022\026\004\036\f\021\r\024 \031\007\026\035\036\027\017\016\ \023\030\036)Tj 0 Tw (-)Tj -0.002 Tw T* (\023\026\030\026\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \b\026\030\026\022\021\036\030\017\f\021\017\022\017 \n\024\ \020\031\021 \r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f )Tj 0.179 Tw T* (\026\032\017\r\035\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\ \027\024\005 \030\026\027\t, \023\030\024\r\036\007\036\027\024 \f\030\026\ \r)Tj 0 Tw (-)Tj 0.112 Tw T* (\027\036\027\017\036 \022\024\035\017\004\036\f\021\r\036\027\027\t\b \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005, )Tj 0.224 Tw T* [(\023\024\035\031\004\036\027\027\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 )0.5(\023\026\021\024\020\017\f\021\024\035\024\020\017\004\036\f\022\024\020\ \024 \017\f)]TJ 0 Tw (-)Tj 0.513 Tw T* (\f\035\036\007\024\r\026\027\017\016 \023\030\036\023\026\030\026\021\026\ . \215\036\030\036\004\017\f\035\036\027\027\t\036 \023\024\022\026\026\ \021\036)Tj 0 Tw (-)Tj 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(\013\036\f\021\r\035\036\027\017\036\n \023\030\017\027\006\017\023\026 \ \006\017\035\017\027\007\030\017\004\036\f\022\024\005 \030\036\036\022\ \006\017\017.)Tj 0.282 Tw 23.244 34.098 Td (\203\024\r\t\005 \f\023\024\f\024\002 \023\035\026\f\021\017\022\017 \(1\ -\016 \020\030\031\023\023\026\) \r\022\035\033\004\026\035 \027\036)Tj 0 Tw (-)Tj T* (\f\022\024\035\034\022\024 \220\021\026\023\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\):)Tj 0.326 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\215\024\f\035\036 )0.5(\n\026\030\022\017\030\024\r\022\017 )0.6(\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\023\024\035\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.059 0 Td (\031\007\026)Tj 0 Tw (-)Tj 0.096 Tw -20.355 -1.218 Td (\035\036\027\017\016 \023\030\036\023\026\030\026\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \202,\207\) \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t \030\026\027\t )Tj -0.016 Tw T* (\r\t\022\030\026\017\r\026\035\f\016, \n\024\002\017\035\017\024\r\t\r\026\ \035\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\220\023\017\021\036\035\017\017\030\024\r\026\035)Tj 0 Tw (-)Tj 0.331 Tw T* (\f\016 \022\024\032\027\024-\023\024\007\022\024\032\027\024-\235\026\f\006\ \017\026\035\034\027\t\005 \035\024\f\022\031\021 \001\017\030\017\027\024\ \005 )Tj 0.113 Tw 0 -1.218 TD (3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\017\021\026\033\013\036\005 \027\024\032\022\036 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \200\). \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.056 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC 0.725 0 Td [(\007\036\235\017\006\017\021\024\n )0.6(\n\016\020\022\017\b )0.5(\021\022\026\027\036\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\035\024\f\022\031\021 )0.5(\r\022\035\033\004\026\035\026\f\034 )0.6(\n\036)]TJ 0 Tw (-)Tj -0.725 -1.218 Td (\007\017\026\035\034\027\026\016 \023\024\030\006\017\016 \002\024\035\034\ \001\024\005 \016\020\024\007\017\004\027\024\005 \n\t\001\006\t.)Tj -0.035 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\200\t\022\030\024\036\027\027\t\005 )0.6(\035\024\f\022\031\021 )0.5(\023\024\020\030\031\032\026\035\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.033 0 Td [(\026\023\036\030\021\031\030\031 )0.6(\n\026\035\024\020\024 )]TJ 0.002 Tw -15.329 -1.218 Td (\021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\017\030\024\r\026\035\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\n \023\030\024\021\017\r\024\023\024\035\024\032\027\ \024\005 \f\021\024)Tj 0 Tw (-)Tj -0.05 Tw T* (\030\024\027\t, \004\021\024 \024\002\036\f\023\036\004\017\r\026\035\024\ \024\002\255\036\n\027\024\036 \026\023\024\035\027\036\027\017\036 \007\ \036\235\036\022)Tj 0 Tw (-)Tj -0.036 Tw 0 -1.218 TD (\021\026 \b\024\030\024\001\024 \r\026\f\022\031\035\016\030\017\017\030\ \024\r\026\027\027\t\n\017 \021\022\026\027\016\n\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \206\).)Tj 0.413 Tw 0 -1.218 TD (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\222)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\023\024\035\024\032\027\024\005 \f\021\024\030\ \024\027\t \n\024\002\017\035\017\024\r\t\r\026\035\f\016 )Tj 0.324 Tw -1.296 -1.218 Td (\021\030\036\031\020\024\035\034\027\t\005 \022\024\032\027\024-\023\024\ \007\022\024\032\027\024-\235\026\f\006\017\026\035\034\027\t\005 \035\024\ \f\022\031\021 )Tj 0.037 Tw 0 -1.218 TD [(\023\024\007 )0.5(\031\020\035\024\n )0.6(60\22680 )0.5(\020\030\026\007\031\f\024\r )0.5(\024\021 )0.5(\006\036\027\021\030\026 )0.6(\030\026\027\t )0.5(\(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC 20.19 0 Td [(1 )0.5(\212\), )]TJ 0.056 Tw -20.19 -1.218 Td (\022\024\021\024\030\t\005 \023\036\030\036\n\036\013\026\035\f\016 \007\ \035\016 \026\022\030\t\021\017\016 \022\024\032\027\024\020\024 \007\036\ \235\036\022)Tj 0 Tw (-)Tj 0.015 Tw T* (\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\006\017\023\031 \023\036\030\036\n\036\013\036\027\027\t\ \b \021\030\036\031\020\024\035\034\027\t\b \035\024\f\022\031\021\024\r\ )Tj 0.19 Tw T* (\002\036 \027\026\021\016\032\036\027\017\016. \214\024\f\022\031\021 \023\ \036\030\036\n\036\013\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030 \030\026\027\t, )Tj 0.066 Tw T* (\f\024\r\n\036\013\026\016 \r\036\030\001\017\027\031 \021\030\036\031\020\ \024\035\034\027\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\001\017\027\024\005 \030\024\n\002\026. )Tj 0.189 Tw T* [(\214\024\f\022\031\021 \235\017\022\f\017\030\024\r\026\035\f\016 )0.5(\024\021\007\036\035\034\027\t\n\017 \031\035\024\r\t\n\017 \001\r\026\n\ \017 )]TJ 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \213\).)Tj 0.138 Tw T* (\200\024 2-\005 \020\030\031\023\023\036 \007\036\235\036\022\021 \031\001\ \017\r\026\035\f\016 \023\024\f\035\024\005\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026)Tj 0 Tw (-)Tj 0.295 Tw T* [(\027\024\r\035\036\027\017\036\n \f\036\007\026\035\017\013\027\024-\026\ \027\026\035\034\027\024\005 \022\035\036\021\004\026\021\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\032\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\024\005 \023\030\024\n\036\032\027\024\f\021\ \027\024\020\024 \007\030\036\027\026\032\026.)Tj 0.161 Tw T* (\200 3-\005 \020\030\031\023\023\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\ \t \031\f\021\026\027\026\r)Tj 0 Tw (-)Tj 0.072 Tw T* [(\035\017\r\026\035\f\016 \f\036\021\004\026\021\t\005 )0.5(\017\n\023\035\026\027\021\026\021, \022\024\021\024\030\t\005 \235\017\022\ \f\017\030\024\r\026\035\f\016 )]TJ -0.014 Tw T* (\n\017\027\017\n\031\n \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \f\017\n\n\036\021\030\017\004\027\024 \030\026\f\023\024\ \035\024\032\036\027\027\t\b \021\024\004\022\026\b: )Tj 0.321 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 \022\030\036\f\021\006\024\r\024-\002\031\020\024\ \030\027\024\005 \f\r\016\022\017 \(\031\020\024\035 \n\036\032\007\031\ )Tj ET q 70.866 122.669 396.85 237.055 re W n q /GS0 gs 396.850395 0 0 237.0545285 70.8661652 122.6695315 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.072 Tw 9 0 0 9 70.8661 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \230\023\020\033\013 \032\027\n\031\025\024\023\032\r\n\006\022\022 \033\ \032\031\026\027\255\025\031\024\023\025\031\235 \032\020\025\013 \033\031\ \024\f\027 \230\f\221\004\230 \033\032\t\026\031\235 \n\022\213\n\022 \033\ \031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r \032\020\n\020 \025\022\255\025\027\020\026\033\r\ \f\t\032\025\031\b\031 )Tj 0 Tw 0 -1.2 TD (\031\023\030\027\f\020 \033\032\t\026\031\235 \n\022\213\n\022 \(\n\031\026\ \026\027\025\023\020\032\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\023\027\n\024\023\027\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.002 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( S)28(tag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(per)-37(ineal w)12(ound reconstruction af)-45.9(ter EL)-36(APE of)]TJ /Span<>> BDC ( )Tj EMC (the rectum for cancer of)Tj /Span<>> BDC ( )Tj EMC [(the low)12.1(er am)16(pullar)-43(y par)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC (the rectum )Tj 0 Tw T* [(\(see e)-14.9(xplanation in the)]TJ /Span<>> BDC ( )Tj EMC [(te)-14.9(xt\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.2152 56.0378 Tm (84)Tj ET endstream endobj 1156 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   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|S}i'f`ά>޵a0&};>V:U! **{y)Ƭ86% FKϾ"p>zX}ӽj]}!ypbGU?+! juKNZ=MQAsxFY F Zb v}ӽkaN4RUMʥ) ?m>t}ӽk vgϺwNȩ*W*J+ӽLٟ:>޵;3G;֧d2ʒ)`t}ӽk_ΏwNIT$ǂd=t}kǶWΏN̩*B$2PUz{?:>c''?֧fUJ ays8WZɹWݒ4}i_ 6_ΏwN̨!.AwU%SN|`4}ӽjveDTJUV!$'R{ x-u}ӽi>ǶP2)zvd "!IS:ACέɃvam22:No*J+T endstream endobj 1160 0 obj <>stream endstream endobj 1154 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.02 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \035\024\022\026\004\036\f\021\r\036\027\027\t\b\ \024\023\031\b\024\035\036\005 \220\021\024\005 \035\024\022\026\035\017\ \026)Tj 0 Tw (-)Tj 0.001 Tw 0 -1.218 TD (\006\017\017, \027\024 \f\024\023\030\024\r\024\032\007\026\035\026\f\034\ \r\t\f\024\022\024\005 \004\026\f\021\024\021\024\005 \023\024\f\035\036\ \024\023\036)Tj 0 Tw (-)Tj 0.05 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \ \(\007\024 49%\) \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\034\027\t\b \030\036\006\017)Tj 0 Tw (-)Tj T* (\007\017\r\024\r \(\007\024 40%\) [1,2].)Tj -0.002 Tc 0.177 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\b \007\024\f\021\017\032\036\027\017\005 \023\024\ \f\035\036\007\027\017\b \007\036\f\016\021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.07 Tw T* [(\035\036\021\017\005 \f\021\026\035\024 \r\027\036\007\030\036\027\017\036\ \022\024\027\006\036\023\006\017\017 \220\022\f\021\030\026\035\036\r\026\ \021\024\030\027\024\005)-2( )]TJ 0.278 Tw 0 -1.218 TD (\002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\024\005\ \220\022\f\021\017\030\023\026\006\017\017 \(\233\035\207\215\233\) \023\ \030\016)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.001 Tw 0 -1.218 TD [(\n\024\005 )0.6(\022\017\001\022\017, )0.6(\023\030\036\007\035\024\032\036\027\027\024\005 )0.5(Holm )0.6(T. )0.6(e)-12(t )0.6(al. )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.463 0 Td [(2007 )0.6(\020. )0.5([2].)-2( )]TJ -0.017 Tw -17.463 -1.218 Td [(\222\024\020\035\026\f\027\024 \220\021\024\005 \022\024\027\006\036\023\ \006\017\017, \031\035\031\004\001\036\027\017\036 \024\027\022\024\035\024\ \020\017\004\036\f\022\017\b)-2( )]TJ 0.095 Tw T* (\030\036\031\035\034\021\026\021\024\r \007\024\f\021\017\020\026\036\021\ \f\016 \026)Tj /Span<>> BDC ( )Tj EMC [(\f\004\036\021 \030\026\f\001\017\030\036\027\017\016 \024\002\255\036\n\ \026)-2( )]TJ 0.458 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\026, )0.5(\r\022\035\033\004\026\033\013\036\020\024 )0.5(\031\007\026\035\036\027\017\036 )0.5(\026\027\026\035\034\027\024\020\024)-2( )]TJ 0.2 Tw T* [(\022\026\027\026\035\026, )0.5(\r\f\036\005 )0.5(\n\t\001\006\t, )0.5(\023\024\007\027\017\n\026\033\013\036\005 )0.5(\026\007\027\017\005 )0.5(\023\030\024\b\024\007,)-2( )]TJ 0.031 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017 [2,4,5]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n A)-24.9(ggar)-38(w)-12(al N. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.2 Tw 0 -1.218 TD [(\026\r\021., \021\026\022\024\005 \023\024\007\b\024\007 \024\002\036\f\023\ \036\004\017\r\026\036\021 \f\027\017\032\036\027\017\036 \004\026\f\021\ \024\021\t)-2( )]TJ 0.105 Tw 0 -1.218 TD (\n\036\f\021\027\024\020\024 \030\036\006\017\007\017\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (30\22640% \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.135 Tw T* [(\n\036\027\036\027\017\036\n \207\215\233 \215\025 [6]. W)22(est N.P. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.074 Tw T* (\006\036\027\021\030\024\r\024\n \017\f\f\035\036\007\024\r\026\027\017\017\ , \024\023\031\002\035\017\022\024\r\026\027\027\024\n \r)Tj /Span<>> BDC ( )Tj EMC (2010)Tj /Span<>> BDC ( )Tj EMC [(\020.,)-2( )]TJ 0.586 Tw T* [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035, \004\021\ \024 \233\035\207\215\233 \f\027\017\032\026\036\021 \004\026\f\021\024\021\ \031)-2( )]TJ 0.032 Tw T* (CRM+)Tj /Span<>> BDC ( )Tj EMC (\f 49,6% \007\024)Tj /Span<>> BDC ( )Tj EMC (20,3%, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \023\036\030\235\024\030\026\006\017\017 \024\ \023\031\b\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.112 Tw T* (\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (28,2% \007\024)Tj /Span<>> BDC ( )Tj EMC [(8,2% [7]. \217\016\007 \017\f\f\035\036\007\024\r\026\027\017\005 \023\024\ \022\026\026\035\017)-2( )]TJ 0.07 Tw T* (\f\b\024\032\017\036 \030\036\031\035\034\021\026\021\t [3,8\22613]. \210\ \007\027\026\022\024 \233\035\207\215\233 \026\f\f\024\006\017\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.02 Tw T* (\030\031\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\017\n\017 \023\024\022\026\026\021\036\035\016\n\017 \023\ \024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b)-2( )]TJ -0.017 Tw T* [(\024\f\035\024\032\027\036\027\017\005 \030\026\027 \023\030\024\n\036\032\ \027\024\f\021\017 \(\235\024\030\n\017\030\024\r\026\027\017\036 \f\036\ \030\024\n,)-2( )]TJ 0.414 Tw T* [(\030\026\r\017\021\017\036 \020\027\024\005\027\024-\f\036\023\021\017\004\ \036\f\022\017\b \024\f\035\024\032\027\036\027\017\005, \027\036\022\030\ \024)-2( )]TJ 0.118 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\b\024\032\007\036\027\017\036 \022\030\026\036\r \023\024\f\035\ \036\024\023\036\030\026\006\017\024\027\027\t\b \030\026\027, \235\024\030\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.119 Tw T* (\n\017\030\024\r\026\027\017\036 \b\030\024\027\017\004\036\f\022\017\b \ \f\r\017\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\024\020\024 \002\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.217 Tw T* [(\035\036\r\024\020\024 \f\017\027\007\030\024\n\026\), \023\024\f\022\024\ \035\034\022\031 \024\027\026 \024\002\030\026\031\036\021 \023\024\035\ \024\f\021\034)-2( )]TJ 0.045 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017 \002\024\035\034\001\036\020\024\ \030\026\n\036\030\026, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.143 Tw T* [(\027\024\005 )0.5(\207\215\233 )0.5(\215\025 )0.5([3,6,14\22619]. )0.6(\025)]TJ /Span<>> BDC ( )Tj EMC 11.664 0 Td [(\f\024\032\026\035\036\027\017\033, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.088 0 Td [(\027\026\f\021\024\016\013\036\036)-2( )]TJ 0.448 Tw -17.752 -1.218 Td [(\r\030\036\n\016 \027\036 \f\031\013\036\f\021\r\031\036\021 \024\023\021\ \017\n\026\035\034\027\t\b \030\036\022\024\n\036\027\007\026\006\017\005\ )-2( )]TJ 0.054 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\r\t\002\024\030\031 \021\024\020\024 \017\035\017 \017\027\024\020\024 \ \f\023\024\f\024\002\026 \023\035\026\f\021\017\022\017 \007\036\235\036\ \022\021\026)-2( )]TJ 0.04 Tw T* [(\021\026\024\r\024\020\024 \007\027\026. \213\f\035\017 \026\031\021\024\ \023\035\026\f\021\017\022\026 \(\023\030\024\f\021\024\036 \023\024\f\035\ \024\005\027\024\036)-2( )]TJ 0.027 Tw T* [(\031\001\017\r\026\027\017\036 \023\030\024\n\036\032\027\024\f\021\027\024\ \005 \030\026\027\t\), \023\030\017\n\036\027\016\036\n\026\016 \023\024\ \f\035\036)-2( )]TJ 0.134 Tw T* [(\207\215\233 )0.5(\215\025, \024\002\036\f\023\036\004\017\r\026\036\021 \r)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \b\024\ \030\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.053 Tw T* [(\001\017\005 \030\036\031\035\034\021\026\021, \021\024 \023\024\f\035\036\ \233\035\207\215\233 \220\021\026 \021\036\b\027\017\022\026 \027\036 \r\ \f\036\020\007\026)-2( )]TJ 0.101 Tw T* [(\007\026\036\021 \r\024\n\024\032\027\024\f\021\034 \007\024\002\017\021\ \034\f\016 \023\024\035\027\024\020\024 \026\022\030\t\021\017\016 \030\ \026\027\t.)-2( )]TJ 0.157 Tw T* (\025\030\024\n\036 \021\024\020\024, \027\026\004\017\021\036\035\034\027\ \t\005 \030\026\027\036\r\024\005 \007\036\235\036\022\021 \023\030\024\n\ \036\032)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.121 Tw T* (\027\024\f\021\017 \027\026\030\016\007\031 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \f\023\024\f\024\002\027\024\f\021\034\033 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\032\017\r\035\036\027\017\033)-2( )]TJ 0.317 Tw T* [(\023\024\f\035\036 )0.5(\023\030\024\r\036\007\036\027\027\024\005 )0.5(\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 )0.5(\b\017\n\017\024\035\031\004\036)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.129 Tw T* (\r\024\005 \021\036\030\026\023\017\017 \f\023\024\f\024\002\f\021\r\031\ \036\021 \030\026\r\017\021\017\033 \030\016\007\026 \023\024\f\035\036\ \024\023\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.098 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005,\ \r)Tj /Span<>> BDC ( )Tj EMC [(\021\024\n \004\017\f\035\036 \235\024\030\n\017\030\024\r\026\027\017\033\ )-2( )]TJ 0.199 Tw T* (\023\030\024\n\036\032\027\024\f\021\027\024\005 \020\030\t\032\017. \215\ \024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n \030\026\027\t\b \026\r\021\024\030\024\r)-2( )]TJ 0.002 Tw T* (\030\026\r\017\021\017\036 \220\021\024\020\024 \024\f\035\024\032\027\036\ \027\017\016 \022\024\035\036\002\035\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\036\035\026\b \024\021)-2( )]TJ 0.081 Tw T* (3,3% \007\024)Tj /Span<>> BDC ( )Tj EMC [(67% [3,14,15]. \207\024\035\034\001\017\027\f\021\r\024 \017\f\f\035\036\ \007\024\r\026\021\036\035\036\005)-2( )]TJ 0.247 Tw T* (\031\021\r\036\030\032\007\026\033\021, \004\021\024 \023\030\026\r\017\035\ \034\027\t\005 \r\t\002\024\030 \023\024\f\035\036\024\023\036\030\026\006\ \017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.006 Tw T* [(\024\027\027\024\005 \030\036\022\024\027\f\021\030\031\022\006\017\017 \ \023\030\024\n\036\032\027\024\f\021\017 \016\r\035\016\036\021\f\016 \026\ \035\024\020\024\n)-2( )]TJ 0.252 Tw T* [(\f\027\017\032\036\027\017\016 \030\017\f\022\024\r \030\026\r\017\021\017\ \016 \030\026\035\017\004\027\t\b \024\f\035\024\032\027\036\027\017\005\ )-2( )]TJ 0.15 Tw T* ([6,18,19]. \203\026)Tj /Span<>> BDC ( )Tj EMC [(\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \024\023\017\ \f\026\027\024 \n\027\024\032\036\f\021\r\024)-2( )]TJ 0.054 Tw T* (\n\036\021\024\007\017\022)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\021 \023\030\024\f\021\024\020\024 \031\001\017\r\026\027\017\016\ \n\036\f\021\027\t\n\017 \021\022\026\027\016\n\017)-2( )]TJ -0.038 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\t\b \030\036\022\024\027\f\021\030\031\022\006\017\005\ \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \n\t\001\036\004)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.07 Tw T* [(\027\024-\022\024\032\027\t\b \035\024\f\022\031\021\024\r \(VRAM-\035\024\ \f\022\031\021, \020\030\026\006\017\035\024\023\035\026\f\021\017\022\026\ ,)-2( )]TJ 0.232 Tw T* (\016\020\024\007\017\004\027\t\036 \035\024\f\022\031\021\t\) \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\004\036\f\022\017\b \017\035\017 \f\017\027\ \021\036\021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.35 Tw T* [(\004\036\f\022\017\b \f\036\021\004\026\021\t\b \017\n\023\035\026\027\021\ \026\021\024\r [5,20]. \207\024\035\034\001\017\027\f\021\r\024)-2( )]TJ -0.062 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.11 0 Td [(\027\017\b )0.5(\f\035\024\032\027\t \r)]TJ /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\027\036\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC 11.419 0 Td [(\027\036 )0.5(\017\f\022\035\033\004\026\033\021 )0.5(\030\026\r\017\021\017\036)-2( )]TJ -0.055 Tw 10.716 64.543 Td (\030\026\027\027\017\b \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\027\017\b \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024)-2( )]TJ 0 Tw T* (\f\021\024\030\024\027\t \030\026\027\t, \035\024\f\022\031\021\024\r, \026\ )Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\024\027\024\030\f\022\017\b \031\004\026\f\021\ \022\024\r.)Tj 0 Tc 0.052 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \022\024\027\f\036\027\f\031\ \f \024\021\027\024\f\017\021\036\035\034\027\024 \030\036\022\024\027\f\ \021\030\031\022)Tj 0 Tw (-)Tj -0.039 Tw T* (\006\017\017 \023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\020\024 \007\027\026 \023\024\f\035\036 \233\035\207\ \215\233 )Tj 0.109 Tw T* [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.6(\r\030\036\n\016 )0.5(\024\021\f\031\021\f\021\r\031\036\021, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 20.789 0 Td (\030\036)Tj 0 Tw (-)Tj 0.125 Tw -20.789 -1.218 Td [(\031\035\034\021\026\021\t \f\030\026\r\027\017\021\036\035\034\027\t\b\ )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 \004\026\f\021\024 \023\030\024\ \021\017)]TJ 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD [(\r\024\030\036\004\017\r\t, \004\021\024 \023\024\007\004\036\030\022\017\ \r\026\036\021 \027\036\024\002\b\024\007\017\n\024\f\021\034 )0.5(\007\026\035\034\027\036\005)]TJ 0 Tw (-)Tj 0 -1.218 TD (\001\017\b \017\t\f\022\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \027\026\023\030\026\r\035\036\027\017\017 [21,22\ ].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 603.0498 Tm [(\017\034\r\237)5( \031\032\032\r\034\230\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.544 Tw 10 0 0 10 274.9606 578.6938 Tm (\211\035\031\004\001\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r \023\035\026\f\021\017\022\017 \023\030\024\n\036\032\027\024\f\021\027\ \024\005 )Tj 0.115 Tw T* (\030\026\027\t \023\024\f\035\036 \233\035\207\215\233 \023\030\016\n\024\ \005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \027\017\032\027\036)Tj 0 Tw (-)Tj 0.029 Tw T* (\026\n\023\031\035\016\030\027\024\020\024 \030\026\022\026 \023\031\021\ \036\n \023\030\017\n\036\027\036\027\017\016 \027\024\r\024\020\024 \f\023\ \024\f\024\002\026 )Tj 0 Tw 0 -1.218 TD (\023\035\026\f\021\017\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 505.6258 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 10 0 0 10 274.9606 481.2698 Tm (\031\t\213\004\005\b \t\217\217\f\r\240\002\004\b\t\235 \t)Tj /Span<>> BDC ( )Tj EMC (\234\003\t\201\r\217\220\t\r \004\217\212\r\220\003\013)Tj /T1_1 1 Tf 0.105 Tw 0 -1.218 TD (\230\f\f\035\036\007\024\r\026\027\017\036 \n\027\024\020\024\006\036\027\ \021\030\024\r\024\036, \030\026\027\007\024\n\017\017\030\024\r\026\027\ \027\024\036, )Tj 0.393 Tw T* (\022\024\027\021\030\024\035\017\030\031\036\n\024\036, \r\t\023\024\035\ \027\036\027\027\024\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\026\036 \022\024\035\024\023\030\024\022)Tj 0 Tw (-)Tj 0.102 Tw T* [(\021\024\035\024\020\017\004\036\f\022\024\020\024 )0.5(\024\021\007\036\035\036\027\017\016 )0.5(\206\207\211\003 )0.5(\203\230\230)]TJ /Span<>> BDC ( )Tj EMC 15.375 0 Td [(\227 )0.5(\025\025\207 \223 )0.5(1 \017\n. )]TJ 0.074 Tw -15.375 -1.218 Td (\023\030\024\235. \222.\200.)Tj /Span<>> BDC ( )Tj EMC (\210\004\026\023\024\r\f\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\016 \026\002\007\024\n\017\027\026\035\034\ \027\024\005 )Tj 0.201 Tw T* (\024\027\022\024\035\024\020\017\017 \206\207\211\003 \025\210\212 \223 \ 1 \(\020.)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\007\026\030\) \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 )Tj 0.166 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\022\021\016\002\030\016 2022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\005 2025 \020\020. \215\030\024\021\024\022\024\035 \017\f\f\035\036\ \007\024)Tj 0 Tw (-)Tj 0.061 Tw T* (\r\026\027\017\016 \002\t\035 \024\007\024\002\030\036\027 \035\024\022\026\ \035\034\027\t\n \220\021\017\004\036\f\022\017\n \022\024\n\017\021\036\ \021\024\n )Tj 0.004 Tw T* (\(\215\030\024\021\024\022\024\035 \223112 \024\021 12.10.2022 \020.\) \017\ )Tj /Span<>> BDC ( )Tj EMC (\026\030\036\020\017\f\021\030\017\030\024\r\026\027 )Tj 0.111 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007\027\024\n \030\036\036\f\021\030\036\ \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \022\024\027)Tj 0 Tw (-)Tj 0.007 Tw T* (\021\030\024\035\017\030\031\036\n\t\b \017\f\f\035\036\007\024\r\026\027\ \017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\026\005\021\036 Cl)-31(inical)56.1(tr)-37(ial.gov: )]TJ 0.046 Tw T* (IDNCT06066931. \230\f\f\035\036\007\024\r\026\027\017\036 \023\030\024\r\ \036\007\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\216\036\035\034\f\017\027\022\f\022\024\005 \007\036\022\035\026\030\026\ \006\017\036\005.)Tj /T1_4 1 Tf T* (\202\032\022\023\027\032\022\022 \021\n\f\005\007\027\025\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027:)Tj /T1_1 1 Tf 0.052 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\026\006\017\036\027\021\t \f\021\026\030\001\036 18 \035\036\021, \f\ \021\030\026\007\026\033\013\017\036 \030\026\022\024\n \027\017\032)Tj 0 Tw (-)Tj 0.15 Tw -1.296 -1.218 Td (\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\007\036\035\026\ \023\030\016\n\024\005 \022\017\001\022\017 \fT1-T4N0-2M0 )Tj 0.174 Tw T* [(\(\023\024 \022\035\026\f\f\017\235\017\022\026\006\017\017 \035\024\022\ \026\004\036\f\021\r\036\027\027\t\b )0.5(\024\023\031\b\024\035\036\005 TNM )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (8-\005 \030\036\007\026\022\006\017\017\).)Tj T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\017\030\031\036\n\024\005 \233\035\207\215\233 \023\030\ \016\n\024\005 \022\017\001\022\017.)Tj 0.152 Tw -1.296 -1.218 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\205\017\017\004\036\f\022\017\005 \f\021\026\021\031\f )0.5(\023\026\006\017\036\027\021\024\r \023\024)]TJ /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 )Tj 0 Tw -1.296 -1.218 Td [(A)35(SA I-II.)]TJ 0.073 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\024\007\023\017\f\026\027\027\024\036 \017\027\235\024\030\n\017\030\ \024\r\026\027\027\024\036 \f\024\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026)Tj 0 Tw (-)Tj -1.296 -1.218 Td (\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj /T1_4 1 Tf T* (\202\032\022\023\027\032\022\022 \025\027 \021\n\f\005\007\027\025\022\t\ :)Tj /T1_1 1 Tf T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\035\024\f\022\024\022\035\036\021\024\004\027\t\005 \030\026\022 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\017\235\017\022\026\006\017\017 \007\017\026\020\027\024\026\ )Tj 0.013 Tw -1.296 -1.218 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\203\026\035\017\004\017\036 \024\f\021\030\t\b \020\027\024\005\027\t\b\ \023\030\024\006\036\f\f\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.058 Tw -1.296 -1.218 Td (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \022\030\036\f\021)Tj 0 Tw (-)Tj T* (\006\024\r\024-\022\024\023\004\017\022\024\r\024\005 \024\002\035\026\f\ \021\017.)Tj /T1_4 1 Tf T* (\202\032\022\023\027\032\022\022 \022\024\n\f\005\007\027\025\022\t \022\ \016)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\t:)Tj /T1_1 1 Tf 0.464 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\210\021\022\026 \023\026\006\017\036\027\021\024\r \024\021 \031\004\026\ \f\021\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \220\021\026\023\036 )Tj 0 Tw -1.296 -1.218 Td (\017\f\f\035\036\007\024\r\026\027\017\016.)Tj /T1_4 1 Tf T* (\004\032\022\025\006\022\033 \032\020\024\033\032\027\030\027\f\027\025\022\ \t \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\013)Tj /T1_1 1 Tf 0.456 Tw T* (\217\026\f\023\030\036\007\036\035\036\027\017\036 \023\026\006\017\036\027\ \021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \023\030\024\r\024\007\017\035\024\f\034 )Tj 0.408 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \022\024\n\023\034\033\021\036\030\027\024\005\ )0.5(\023\030\024\020\030\026\n\n\t \020\036\027\036\030\026\021\024\030\026 \ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (83)Tj ET endstream endobj 1153 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 296.9706 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 296.9706 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 259.7628 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 259.7628 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 205.6936 cm 0 0 m 453.543 0 l S Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 119.1012 723.8861 Tm [(Reconstr)10.1(uction of\022)-23.3(perineal w)11(ound and pelvic floor )]TJ 0.929 -1.167 Td [(af)-31(ter e)21(xtr)21(ale)11(v)10(ator abdominoperineal e)21(x)21(cision )]TJ 0.004 -1.167 Td [(of\022)-23.3(th)11(e r)31.1(ectum: a\022)-23.3(nov)12(el solution to\022)-23.2(th)11(e pr)20(oblem )]TJ 0.528 -1.167 Td [(\(r)31(esults of\022)-23.3(a\022)-23.3(multicenter r)21.1(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 636.3822 Tm [(V)31(adim\022)-23.3(V)62(.\022)-23.2(P)9.9(olovinkin)]TJ 8.162 0 0 8.162 181.6265 641.0442 Tm (2,3)Tj 0.023 Tw 14 0 0 14 193.5102 636.3822 Tm [(, Nik)11(olay\022)-23.2(V)62(.\022)-23.3(Dor)20(onin)]TJ 0 Tw 8.162 0 0 8.162 309.0065 641.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 313.6425 636.3822 Tm [(, Ruslan M.-)-42(A)-31(. Shir)21.1(aliy)10(e)11(v)]TJ 0 Tw 8.162 0 0 8.162 454.0441 641.0442 Tm (1)Tj 14 0 0 14 458.6801 636.3822 Tm (, )Tj -27.701 -1.143 Td [(Ale)21(x)11(an\022)-23.2(A)-31(.\022)-23.3(Khalaf)-31(y)21(an)]TJ 8.162 0 0 8.162 188.7664 625.0442 Tm (4)Tj 0.023 Tw 14 0 0 14 193.4024 620.3822 Tm [(, V)31(aleriy\022)-23.2(B.\022)-23.3(K)41(aushansky)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 325.1384 625.0442 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 336.459 620.3822 Tm [(, Ev)10(geniy\022)-23.2(A)-31(.\022)-23.3(Ermak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 457.4158 625.0442 Tm (1)Tj 5.83 0 0 5.83 70.8661 606.043 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 602.713 Tm [(Clinical Oncology Dispensar)-30.9(y No. 1 \(Dimitr)20(ov)10(a\022)-23.2(st., 1)150(46, Kr)21.1(asnodar)52(, 3500)25(40, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 594.043 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 590.713 Tm [(Scientif)-20.9(ic Resear)31(ch Institute\022)-23.2(\230 Ochapov)10(sky Regional Clinical Hospital No. 1 \(1st May\022)-23.3(st., 1)112(6)58.1(7)127(, Kr)21(asnodar)52(, )]TJ -0.331 -1.2 Td (350086, Russia\))Tj 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 570.043 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 566.713 Tm [(K)31(uban State Medical Univ)12.1(er)20(sit)-20(y \(Sedina\022)-23.2(st., 4, Kr)21(asnodar)52(, 350063, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 558.0431 Tm (4)Tj 0.023 Tw 10 0 0 10 74.1775 554.7131 Tm [(K)31(uban State Univ)12(er)20(sit)-19.9(y \(Stavr)20(opolskay)21.1(a\022)-23.3(st., 1)150(49, Kr)21(asnodar)52(, 3500)25(40, Russia\))]TJ /T1_1 1 Tf 0.006 Tw 9 0 0 9 119.0551 536.2091 Tm [(AIM: to im)16(p)46(rov)13(e the outcomes of per)-36.9(ineal w)12(ound reconstruction af)-46(ter EL)-35.9(APE for low rectal cancer by applying a ne)10(w )]TJ 0.023 Tw 0 -1.111 TD [(reconstructiv)13.1(e techniq)14(ue.)]TJ 0.129 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a cohor)-40(t multicenter randomized controlled tr)-37(ial included 150 patients, allocated into )]TJ 0.104 Tw T* [(three g)14(roups depending on the per)-36.9(ineal w)12(ound reconstruction techniq)14(ue: ne)10(w techniq)14(ue \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\), sim)16(ple w)12(ound )]TJ 0.011 Tw T* (closure \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50\), mesh repair \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\). The time of the reconstruction stag)12(e, blood loss, pain intensity)42(, freq)14(uency of )]TJ 0.035 Tw 0 -1.111 TD [(early )0.6(\(up )0.5(to )0.6(30 )0.5(d)26(ays\) )0.6(\(seroma, )0.6(hematoma, )0.6(suppuration, )0.6(f)-22(lap )0.6(necrosis\) )0.6(and )0.5(late )0.5(\(median )0.5(14 )0.5(months\) )0.5(postoperativ)13(e )]TJ -0.01 Tw 0 -1.111 TD [(com)16(plications \(f)-42.9(istulas, abscesses, per)-37(ineal her)-14(nias, chronic pain syndrome\) w)12(ere studied; patient q)14(uality of life w)13(as )]TJ 0 Tw 0 -1.111 TD (assessed.)Tj 0.032 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the time of the reconstruction stag)12(e w)13(as long)12.1(er in the ne)10(w techniq)14(ue g)14(roup \(50 [45; 55] min\) com)16(pared )]TJ 0.036 Tw 0 -1.111 TD [(to 20 [20; 25] min for sim)16.1(ple closure and 35 [30; 40] min for mesh repair \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.0001\). P)18(ain intensity on d)26(ays 1, )]TJ 0.028 Tw T* [(3, and 5 w)13(as low)12.1(er in the ne)10(w reconstruction )0.5(techniq)14(ue g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.005, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.002, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.0007\). The freq)13.9(uency of )]TJ 0.001 Tw T* [(early com)16(plications w)13(as 16% in the ne)10(w techniq)14(ue g)14(roup v)13(ersus 32% and 24% in the com)16(par)-37(ison g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.17\). )Tj -0.018 Tw T* [(The dif)-39.9(ferences w)12(ere no)13(t statistically signif)-43(icant. W)28.9(ound suppuration dev)13(eloped in 2)]TJ /Span<>> BDC ( )Tj EMC (\(4%\) vs. 8)Tj /Span<>> BDC ( )Tj EMC (\(16%\) and 5)Tj /Span<>> BDC ( )Tj EMC (\(10%\), )Tj 0.061 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.43. Late com)16.1(plications w)12(ere recorded in 2% of patients in the ne)10(w reconstruction g)14(roup v)13(ersus 14% in each )]TJ 0.079 Tw T* [(of the com)16(par)-37(ison g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.07\). The rate of chronic f)-43(istulas \(0, 2)]TJ /Span<>> BDC ( )Tj EMC (\(4%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.22\), per)-37(ineal her)-14(nia )]TJ 0.068 Tw T* (\(1)Tj /Span<>> BDC ( )Tj EMC (\(2%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), 3)Tj /Span<>> BDC ( )Tj EMC (\(6%\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.22\). Quality of life indicators w)12(ere signif)-43(icantly better in the ne)10(w reconstruction )]TJ 0.023 Tw T* [(g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.0001\).)Tj 0.05 Tw 0 -1.111 TD [(C)21(ON)22(CLUSIONS: per)-36.9(ineal w)12(ound reconstruction using the ne)10(w techniq)14(ue af)-46(ter EL)-35.9(APE for rectal cancer req)14(uires more )]TJ 0.109 Tw 0 -1.111 TD [(time, but it p)46(rovides reduced postoperativ)13.1(e pain intensity)42.1(, im)16.1(p)46(rov)13(ed q)14(uality of life, and demonstrates a clinically )]TJ 0.023 Tw T* [(signif)-43(icant trend tow)13.1(ards reducing the freq)14(uency of early and late postoperativ)13(e com)16(plications.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 330.9398 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.074 Tw 4.948 0 Td [( )0.5(\027xtralev)16.1(ator )0.5(abdominoper)-36.9(ineal )0.6(e)-15(xcision, )0.6(rectal )0.5(cancer)61.1(, )0.5(reconstructiv)13.1(e )0.5(surg)12(er)-43(y)42(, )0.5(per)-36.9(ineal )0.5(w)12(ound, )0.6(postoperativ)13(e )0.6(com)16(plications, )0.6(q)14(uality )]TJ 0.023 Tw -4.953 -1.2 Td (of)Tj /Span<>> BDC ( )Tj EMC [(life, p)46(rediction, multicenter study)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.039 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.3(O)-4.5(R)8.9( C)-17.3(I)-15.5(T)45.5(A)37.7(T)-24.4(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.025 Tc -0.035 Tw 6.426 0 Td [( P)-0.8(o)-15.5(l)-20.8(o)-10.2(v)-51.6(i)-3.1(n)-8.7(k)-41(i)-3.1(n)]TJ /Span<>> BDC ( )Tj EMC [(V)39.8(.)40.7(V)39.8(.)-23.4(, S)-10.2(h)-13.8(i)-5.9(r)-30.7(a)-11.3(l)-16.6(i)-17.1(y)-20.4(e)-15.6(v)]TJ /Span<>> BDC ( )Tj EMC [(R)-21.3(.)-7.2(M)-7(.)12(-)-8.3(A)-22.8(.)-23.4(, K)-20.4(h)-8.2(a)-11.3(l)-37.7(a)-14.3(f)-67.5(y)-24.1(a)-7.5(n)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)-23.8(A)-22.9(.)-23.4(, K)-30.3(a)-8.9(u)-21.8(s)-8.7(h)-8.2(a)-7.5(n)-11.1(s)-11(k)-45.5(y)]TJ /Span<>> BDC ( )Tj EMC [(V)39.9(.)0.5(B)3.4(.)-23.4(, E)-1.8(r)-35.8(m)-8.2(a)-11(k)-3.6(o)-10.2(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.5(.)-23.8(A)-22.9(. R)-6.6(e)-19(c)-6.3(o)-9.1(n)-11.1(s)-29.2(t)-30.7(r)-30.2(u)-6.3(c)-41.4(t)-46.1(i)-6.7(o)-9.1(n o)-12(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-24.6(e)-12(r)-56.3(i)-3(n)-16(e)-12.9(a)-11.3(l w)-13.4(o)-13.2(u)-4.9(n)-14.4(d)25( )]TJ 0.033 Tc 0.029 Tw -6.431 -1.2 Td [(a)-7.6(n)-14.5(d p)-24.7(e)-18(l)-5.6(v)-51.7(i)-5(c f)-47(l)-20.9(o)-18.6(o)-11.8(r a)-14.4(f)-66.2(t)-24.7(e)-12.1(r e)-33.1(x)-44.7(t)-30.8(r)-30.8(a)-11.4(l)-23.7(e)-15.8(v)-28.3(a)-18.2(t)-21.9(o)-11.8(r a)-18.2(b)-22.1(d)-11.1(o)-9.2(m)-14.5(i)-3.2(n)-11.9(o)-8.3(p)-24.6(e)-12.1(r)-56.4(i)-3.2(n)-16.1(e)-13(a)-11.4(l e)-33.1(x)-5.4(c)-38.2(i)-7.4(s)-26.1(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e r)-19.1(e)-19.1(c)-41.5(t)-22.3(u)-7(m)4.5(: a)]TJ /Span<>> BDC ( )Tj EMC [(n)-11.8(o)-10.4(v)-18.6(e)-18(l s)-19.1(o)-15.6(l)-23.3(u)-16.3(t)-46.2(i)-6.7(o)-9.2(n t)-21.8(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15(e p)-13.7(r)-15.7(o)-11.6(b)-18.2(l)-23.7(e)-11.5(m \()39.2(r)-19.1(e)-22.8(s)-8.7(u)-8.4(l)-15.4(t)-48.9(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(m)-8.1(u)-8.4(l)]TJ 0 Tc 0 Tw 56.341 0 Td (-)Tj 0.029 Tc -0.035 Tw -56.341 -1.2 Td [(t)-46.1(i)-4.9(c)-9.6(e)-11.5(n)-17.2(t)-24.6(e)-12(r r)-30.7(a)-7.5(n)-14.5(d)-11(o)-9.1(m)-14.4(i)-8.2(z)-13.9(e)-21(d s)-29.3(t)-22.2(u)-10.3(d)-20.4(y)19.7(\))10.5(. )]TJ /T1_1 1 Tf 0.039 Tc -0.039 Tw [(K)14(ol)3.7(op)2.5(r)3.2(o)3.4(k)-19.1(t)2.3(ol)3.7(o)-3.3(g)-13.1(i)6.8(a)5.9(.)]TJ /T1_3 1 Tf 0.029 Tc -0.035 Tw 19.571 0 Td [( 2)-8.8(0)-3.7(2)4.3(6)19.9(;)9.9(2)-1.3(5)1(\()37.8(1)44.3(\))14.6(:)-3.7(8)-1.4(1)26.5(\226)-5.2(91)4.3(. \()-0.8(i)-3.1(n R)-6.4(u)-21.8(s)-22.2(s)-15.5(.)43.3(\))10.5(. h)-17.1(t)-49.3(t)-29.3(p)-18.7(s)-7.9(:)2(/)84.8(/)36.5(d)-11(o)-12.5(i.)2.8(o)-11.7(r)-16.6(g)-22.7(/)11.2(1)14.1(0)6.6(.)-5.5(3)8(3)-15.9(8)1.4(7)4.7(8/)7.9(2)-8.8(0)9.4(7)-1.8(3)-13.2(-)41.3(7)10.7(5)0.5(5)-8.8(6)-26.6(-)9.7(2)-8.8(0)-3.7(2)4.3(6)-26.7(-)9.8(2)-1.3(5)-23.4(-)55.2(1)27(-)-25.2(8)-1.4(1)27(-)-4.1(91)]TJ /T1_2 1 Tf 0.017 Tc 0.345 Tw -19.566 -2.617 Td [(\026\020\021\033\030)4.9( \020\036\017)4.9( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0.007 Tc 0.35 Tw 11.372 0 Td [( \220\031\032\031\025\022\025 \001.\211., \216\221\210\207 \253\202\f\022\ \025\022\007\027\024\n\022\235 \031\025\n\031\f\031\b\022\007\027\024\n\022\ \235 )0.5(\030\022\024\033\020\025\024\027\032 \2421\273 \215\022\025\016\030\032\020\ \021\020 \202\032\020\024\025\031\030\020\032\024\n\031\b\031 \n\032\020\ \t,)7( )]TJ 0 Tc 0.023 Tw -11.377 -1.2 Td (\r\f.)Tj /Span<>> BDC ( )Tj EMC (\220\022\026\022\023\032\031\021\020, \030.)Tj /Span<>> BDC ( )Tj EMC (146, \202\032\020\024\025\031\030\020\032, 350040, \206\031\024\024\022\t\ ; \023\027\f.: +7)Tj /Span<>> BDC ( )Tj EMC (\(918\) 626-55-13; e-mail: nikolajdoronin23@mail.ru)Tj /T1_2 1 Tf 0.012 Tc 0.344 Tw 0.005 -1.2 Td [(ADDRESS)5.2( F)13.1(OR)5.1( C)19.1(ORRESPONDEN)23.2(CE:)]TJ /T1_1 1 Tf 0.002 Tc 0.349 Tw 14.754 0 Td [( Doronin N)28.2(.V)61.1(., Clinical Oncology Dispensar)-42.9(y N)17.1(o. 1, Dimitrov)16.2(a st., 146, Krasnod)26.1(ar)61.1(, 350040, R)22.1(ussia;)2( )584( )]TJ 0 Tc 0.023 Tw -14.759 -1.2 Td (tel.:)Tj /Span<>> BDC ( )Tj EMC (+7)Tj /Span<>> BDC ( )Tj EMC (\(918\))Tj /Span<>> BDC ( )Tj EMC [(626-55-13; e-mail: nik)13(ola)10.1(jdoronin23@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 23.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 23.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 23.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 23.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 140.2859 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.282 Tw 10 0 0 10 70.8661 115.9299 Tm [(\230\f\021\024\030\017\016 \030\026\r\017\021\017\016 \b\017\030\031\030\ \020\017\004\036\f\022\017\b )0.5(\n\036\021\024\007\024\r \035\036\004\036\027\017\016 )]TJ 0.203 Tw 0 -1.218 TD (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \024\023\031\b\024\035\ \036\005 \023\030\016\n\024\005 \022\017\001\022\017 \027\026\004\026\035\ \026\f\034 )Tj 0.194 Tw T* (\036\013\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\036\007\017\027\t XVIII \r\036\022\026, \027\024 \030\036\r\024\ \035\033\006\017\024\027\027\024\036 \f\024)Tj 0 Tw (-)Tj -0.004 Tw T* (\002\t\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\023\030\026\r\035\036\027\017\017 \023\030\024\017\ \024\001\035\024 \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (1908)Tj /Span<>> BDC ( )Tj EMC (\020., )Tj -0.047 Tw 23.244 6.089 Td [(\022\024\020\007\026 W)-16(ill)-31(iam Er)-14.9(nest Miles, \024\f\027\024\r\t\r\026\016\f\034 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\024\027\017\n\026\027\017\017 )Tj 0.019 Tw T* (\030\026\f\023\030\024\f\021\030\026\027\036\027\017\016 \024\023\031\b\024\ \035\036\r\024\020\024 \023\030\024\006\036\f\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017)Tj 0 Tw (-)Tj -0.035 Tw T* (\004\036\f\022\017\n \023\031\021\016\n, \023\030\036\007\035\024\032\017\ \035 \027\024\r\031\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\021 \023\036\030\017\024\007 \r\030\036\n\036)Tj 0 Tw (-)Tj 0.146 Tw T* (\027\017 \024\023\036\030\026\006\017\033)Tj /Span<>> BDC ( )Tj EMC (\227 \002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\031\ \033 \220\022\f\021\017\030\023\026)Tj 0 Tw (-)Tj -0.002 Tw T* (\006\017\033 \023\030\016\n\024\005 \022\017\001\022\017 \(\207\215\233 \ \215\025\). \233\021\026 \024\023\036\030\026\006\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\017\036 )Tj 0.144 Tw T* (\020\024\007\t \f\021\026\035\026 \024\f\027\024\r\027\t\n \030\026\007\017\ \022\026\035\034\027\t\n \r\n\036\001\026\021\036\035\034\f\021\r\024\n \ )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 544.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 73.5728 535.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1276 56.0378 Tm (82)Tj ET endstream endobj 1150 0 obj [1161 0 R] endobj 1151 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 171.4105 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 171.4105 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 124.6027 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 124.6027 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-81-91)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 62.3798 695.3259 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-10(\026\t\025\221 \005\017\t\217 \n\022)-23.3(\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 )]TJ 0.436 -1.105 Td [(\224\025\016)-10(\020\004 \237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-10(\026\t\025\221 )]TJ -0.938 -1.105 Td [(\237\r\016)-10(\026\n\005\224\017\n\n \224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\ \004 \005\004\204\004\t\n\004 \224\005\025\255\020\004\024\217 )]TJ 0.594 -1.105 Td [(\(\005\004\212)21(\002\020\200)21.1(\026)10.9(\017\026\217 \024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 )]TJ 0 Tw 7.775 -1.105 Td [(\n\016\016)-10(\020\004\202\025\b\017\t\n\213\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 586.822 Tm [(\034\025\020\025\b\n\t\r\n\t\022)-23.2(\021.\021.)]TJ 8.162 0 0 8.162 138.8981 591.484 Tm (2,3)Tj 0.023 Tw 14 0 0 14 150.7818 586.822 Tm [(, \201\025\005\025\t\n\t\022)-23.2(\007.\021.)]TJ 0 Tw 8.162 0 0 8.162 238.2888 591.484 Tm (1)Tj 0.023 Tw 14 0 0 14 242.9248 586.822 Tm [(, \222\n\005\017\020\n\004\b\022)-23.2(\033)124(.\235.-)-63(\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 359.1032 591.484 Tm (1)Tj 0.023 Tw 14 0 0 14 363.7392 586.822 Tm [(, \205\017\020\017\216\213\t\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 452.8979 591.484 Tm (4)Tj 14 0 0 14 457.5339 586.822 Tm (, )Tj -29.644 -1.143 Td [(\037)41(\017\002\204\017\t\016\r\n\221\022)-23.3(\021.\006.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 140.1448 575.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 151.4654 570.822 Tm [(, \240\005\024\017\r)10(\025\b\022)-23.2(\240.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 236.4105 575.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 556.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 553.1527 Tm [(\031\006)42(\227)31(\203 \253\037\020\n\t\n\225\004\016\r\n\221 \025\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \202\n\016\224\017\t\016\004\005 \ \0231\273 \235\n\t\212\202\005\017\b\017 \037)20(\005\017\016\t\025\202\017\005\016\r)10(\025\013)10(\025 \r\005\017\213 \(\002\020.\022)-23.3(\201\n\024\n\026\005\025\b\017, )]TJ -0.331 -1.2 Td [(\202.\022)-23.3(1)150(46, \013)62.1(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-32(, 3500)25(40, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 532.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 529.1527 Tm [(\031\006)42(\227)31(\203 \253\007\017\002\225\t\025-\n\016\016)-9.9(\020\004\202\025\b\017\026)11(\004\020\200\016\r\n\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026\022)-23.3(\230 \037)20(\005\017\004\b\017\213 \r)-9.9(\020\n\t\n\225\004\016\r\017\213 \255\025\020\200\t\n\017 \0231 \n\024.\ \022)-23.3(\224\005\025\216)-51.9(. )]TJ -0.331 -1.2 Td [(\001.\021.\022)-23.3(\036\225\017\224\025\b\016\r)10.1(\025\013)10(\025\273 \235\n\t\212\202\005\017\b\017 \037)20(\005\017\016\t\025\202\017\005\016\r)10(\025\013)10(\025 \r\005\017\213 \(\002\020.\022)-23.3(1 \235\017\213, \202.\022)-23.2(1)112(6)58(7)127(, \013)62(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-32(, 350086, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 508.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 505.1528 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\255\017\t\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020\ .\022)-23.3(\001\004\202\n\t\017, \202.\022)-23.2(4, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-32(, 350063, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 484.4828 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 481.1529 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\255\017\t\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \002\t\n\b\004\005\016\n\026)11(\004\026\273 \(\002\020.\022)-23.2(\001\026)11(\017\b\005\025\224\025\020\200\016\r\017\213, \202.\022)-23.3(1)150(49, \013)62(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-31.9(, )]TJ -0.331 -1.2 Td [(3500)25(40, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0.021 Tw 9 0 0 9 90.7087 450.649 Tm [(\217\221\217\205\001\217\211\003\001\002\036: )0.6(\204\n\024\023\032\020\f\027\021\020\023\031\032\025\020\t )0.7(\240\032\005\213\025\031-\033\032\031\026\027\255\025\031\024\023\025\020\ \t )0.7(\204\n\024\023\022\032\033\020\006\022\t )0.5(\(\230\f\221\004\230\) )0.6(\033\032\t\026\031\235 )0.6(\n\022\213\n\022 )0.5(\024\031\033\032\t\255\027\025\020 )]TJ 0.023 Tw 0 -1.111 TD (\024)Tj /Span<>> BDC ( )Tj EMC (\203\031\032\026\022\032\031\021\020\025\022\027\026 \031\240\213\022\032\ \025\031\b\031 \030\027\203\027\n\023\020 \033\032\031\026\027\255\025\031\ \024\023\022, \033\032\022\021\031\030\t\212\027\b\031 \n)Tj /Span<>> BDC ( )Tj EMC (\021\013\024\031\n\031\235 \007\020\024\023\031\023\027 \031\024\f\031\255\ \025\027\025\022\235.)Tj 0.06 Tw T* (\037\036\035\034: \r\f\r\007\213\027\025\022\027 \032\027\016\r\f\017\023\ \020\023\031\021 \032\027\n\031\025\024\023\032\r\n\006\022\022 \033\032\ \031\026\027\255\025\031\024\023\025\031\235 \032\020\025\013 \033\031\024\ \f\027 \230\f\221\004\230 \033\032\t\026\031\235 \n\022\213\n\022 \033\031\ )Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r )Tj 0.023 Tw T* (\032\020\n\020 \025\022\255\025\027\020\026\033\r\f\t\032\025\031\b\031 \ \031\023\030\027\f\020 \033\r\023\027\026 \033\032\022\026\027\025\027\025\ \022\t \025\031\021\031\b\031 \024\033\031\024\031\240\020 \033\f\020\024\ \023\022\n\022.)Tj 0.215 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\n\031\b\031\032\023\025\031\027 \026\025\031\b\031\006\027\025\023\032\031\ \021\031\027 \032\020\025\030\031\026\022\016\022\032\031\021\020\025\025\ \031\027 \n\031\025\023\032\031\f\022\032\r\027\026\031\027 \022\024\024\ \f\027\030\031\021\020\025\022\027 )Tj 0.249 Tw 0 -1.111 TD (\021\n\f\005\007\027\025\013 150 \033\020\006\022\027\025\023\031\021, \032\ \020\024\033\032\027\030\027\f\027\025\025\013\200 \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \024\033\031\024\031\ \240\020 \033\f\020\024\023\022\n\022 \033\032\031\026\027\255\025\031\024\ \023\025\031\235 \032\020\025\013 )Tj 0.026 Tw 0 -1.111 TD (\021)Tj /Span<>> BDC ( )Tj EMC (\023\032\022 \b\032\r\033\033\013: \025\031\021\013\235 \024\033\031\024\ \031\240 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\), \033\032\031\024\023\031\027 \r\213\022\021\020\025\022\027 )0.5(\032\020\025\013 \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\), \033\f\020\024\023\022\n\020 )0.5(\024\027\023\007\020\023\013\026 \204\025\030\031\033\032\031\023\027\016\ \031\026 )]TJ 0.044 Tw T* (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50\). \002\016\r\007\020\f\022 \033\032\031\030\031\f\255\022\023\027\f\017\ \025\031\024\023\017 \204\023\020\033\020 \033\f\020\024\023\022\n\022, \ \n\032\031\021\031\033\031\023\027\032\005, \022\025\023\027\025\024\022\ \021\025\031\024\023\017 \240\031\f\027\021\031\b\031 \024\022\025\030\032\ \031\026\020, )Tj -0.004 Tw T* (\007\020\024\023\031\023\r \032\020\025\025\022\200 \(\030\031 30 \024\r\ \023\031\n\) \(\024\027\032\031\026\020, \b\027\026\020\023\031\026\020,\ \025\020\b\025\031\027\025\022\027, \025\027\n\032\031\016 \f\031\024\n\ \r\023\020\), \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\016\030\025\022\200 \(\026\027\030\022\020\025\020 14)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\t)Tj 0 Tw (-)Tj 0.05 Tw T* (\006\027\021\) \033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\ \013\200 \031\024\f\031\255\025\027\025\022\235 \(\024\021\022\212\022, \ \020\240\024\006\027\024\024\013, \033\032\031\026\027\255\025\031\024\023\ \025\013\027 \b\032\013\255\022, \200\032\031\025\022\007\027\024\n\022\235\ \240\031\f\027\021\031\235 \024\022\025\030)Tj 0 Tw (-)Tj 0.023 Tw T* (\032\031\026\), \031\006\027\025\022\021\020\f\022 \n\020\007\027\024\023\ \021\031 \255\022\016\025\022 \033\020\006\022\027\025\023\031\021.)Tj 0.194 Tw T* [(\206\036\207\210\035\034\003\201: )0.6(\033\032\031\030\031\f\255\022\023\027\f\017\025\031\024\023\017 )0.5(\204\023\020\033\020 )0.6(\033\f\020\024\023\022\n\022 )0.5(\240\031\f\017\213\027 )0.6(\021)]TJ /Span<>> BDC ( )Tj EMC 26.851 0 Td [(\b\032\r\033\033\027 )0.5(\025\031\021\031\b\031 )0.5(\024\033\031\024\031\240\020 )0.5(\(50 )0.6([45; )0.5(55] )0.5(\026\022\025.\) )]TJ 0.15 Tw -26.851 -1.111 Td (\033\032\031\023\022\021 20 [20; 25] \026\022\025. \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\024\023\031\026 \r\213\022\021\020\025\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (35 [30; 40] \026\022\025. \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\f\020\024\023\022\n\027 \024\027\023\n\031\235 \(p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\). )Tj 0.107 Tw T* (\002\025\023\027\025\024\022\021\025\031\024\023\017 \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020 \025\020)Tj /Span<>> BDC ( )Tj EMC (1, 3, 5-\027 \024\r\023\n\022 \025\022\255\027 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \025\031\021\031\b\031 \024\033\031\024\031\240\020\ \033\f\020\024\023\022\n\022 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005, )Tj 0.076 Tw 0 -1.111 TD (\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002, \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0007\). \002\026\027\027\023 \026\027\024\023\031 \023\027\025\030\027\ \025\006\022\t \n)Tj /Span<>> BDC ( )Tj EMC (\024\025\022\255\027\025\022\005 \007\020\024\023\031\023\013 \032\020\025\ \025\022\200 \031\024\f\031\255\025\027\025\022\235 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \025\031\021\031\b\031 )Tj 0.001 Tw 0 -1.111 TD [(\024\033\031\024\031\240\020 )0.6(16% )0.5(\033\032\031\023\022\021 )0.6(32% )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 11.549 0 Td [(24% )0.6(\021)]TJ /Span<>> BDC ( )Tj EMC 2.692 0 Td [(\b\032\r\033\033\020\200 )0.6(\024\032\020\021\025\027\025\022\t )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 9.027 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.733 0 Td [(0,17\). )0.6(\020\n\255\027 )0.5(\031\023\026\027\007\027\025 )0.6(\023\032\027\025\030 )0.5(\n)]TJ /Span<>> BDC ( )Tj EMC 12.775 0 Td [(\r\026\027\025\017\213\027\025\022\005 )0.6(\007\020\024\023\031)]TJ 0 Tw (-)Tj 0.007 Tw -36.777 -1.111 Td (\023\013 \033\031\016\030\025\022\200 \031\024\f\031\255\025\027\025\022\ \235 \r)Tj /Span<>> BDC ( )Tj EMC (2% \033\020\006\022\027\025\023\031\021 \b\032\r\033\033\013 \025\031\021\ \031\235 \033\f\020\024\023\022\n\022 \033\032\031\023\022\021 14%)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\n\020\255\030\031\235 \022\016)Tj /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\022\021\020\027\026\013\200 )Tj 0.004 Tw T* (\b\032\r\033\033 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07\), \021\n\f\005\007\020\t \032\020\016\021\022\023\022\027 \200\032\ \031\025\022\007\027\024\n\022\200 \024\021\022\212\027\235 \(0, 2)Tj /Span<>> BDC ( )Tj EMC (\(4%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,22\), \033\032\031\026\027\255\025\031\024\023\025\031\235 \b\032\013\255\ \022 )Tj 0.116 Tw T* (\(1)Tj /Span<>> BDC ( )Tj EMC (\(2%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), 3)Tj /Span<>> BDC ( )Tj EMC (\(6%\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,22\), \200\032\031\025\022\007\027\024\n\031\b\031 \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020 \(2)Tj /Span<>> BDC ( )Tj EMC (\(4%\), 6)Tj /Span<>> BDC ( )Tj EMC (\(12%\), 3)Tj /Span<>> BDC ( )Tj EMC (\(6%\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,28\). )Tj 0.023 Tw T* (\004\031\n\020\016\020\023\027\f\022 \n\020\007\027\024\023\021\020 \255\ \022\016\025\022 \016\025\020\007\022\026\031 \f\r\007\213\027 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \025\031\021\031\235 \033\f\020\024\023\022\n\022 \(\ p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\).)Tj 0.05 Tw T* [(\211\201\211\217\220\201: )0.5(\030\f\t )0.6(\021\013\033\031\f\025\027\025\022\t )0.6(\033\f\020\024\023\022\n\022 )0.5(\033\032\031\026\027\255\025\031\024\023\025\031\235 )0.6(\032\020\025\013 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 25.611 0 Td [(\033\032\022\026\027\025\027\025\022\027\026 )0.5(\025\031\021\031\b\031 )0.5(\024\033\031\024\031\240\020 )0.5(\033\031\024\f\027 )0.5(\230\f\221\004\230 )0.5(\033\032\t)]TJ 0 Tw (-)Tj 0.029 Tw -25.611 -1.111 Td (\026\031\235 \n\022\213\n\022 \023\032\027\240\r\027\023\024\t \240\031\f\ \017\213\027 \021\032\027\026\027\025\022, \025\031 \031\025\020 \031\240\ \027\024\033\027\007\022\021\020\027\023 \024\025\022\255\027\025\022\027\ \022\025\023\027\025\024\022\021\025\031\024\023\022 \033\031\024\f\027\ \031\033\027\032\020\006\022\031\025\025\031\235 )Tj 0.031 Tw T* (\240\031\f\022, \r\f\r\007\213\027\025\022\027 \n\020\007\027\024\023\021\ \020 \255\022\016\025\022 \022)Tj /Span<>> BDC ( )Tj EMC (\030\027\026\031\025\024\023\032\022\032\r\027\023 \n\f\022\025\022\007\027\ \024\n\022 \016\025\020\007\022\026\r\005 \023\027\025\030\027\025\006\022\ \005 \n)Tj /Span<>> BDC ( )Tj EMC (\024\025\022\255\027\025\022\005 \007\020\024\023\031\023\013 )Tj 0.023 Tw 0 -1.111 TD (\032\020\025\025\022\200 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\016\030\025\022\200 \033\031\024\f\027\031\033\027\032\020\006\022\ \031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235.)Tj /T1_2 1 Tf 0.01 Tc 0.133 Tw 8 0 0 8 42.5596 205.3797 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.138 Tw 8.608 0 Td ( \204\n\024\023\032\020\f\027\021\020\023\031\032\025\020\t \240\032\005\ \213\025\031-\033\032\031\026\027\255\025\031\024\023\025\020\t \204\n\024\ \023\022\032\033\020\006\022\t, \032\020\n \033\032\t\026\031\235 \n\022\ \213\n\022, \032\027\n\031\025\024\023\032\r\n\023\022\021\025\020\t \200\ \022\032\r\032\b\022\t, \033\032\031)Tj 0 Tw (-)Tj 0.023 Tw -8.613 -1.2 Td (\026\027\255\025\031\024\023\025\020\t \032\020\025\020, \033\031\024\f\027\ \031\033\027\032\020\006\022\031\025\025\013\027 \031\024\f\031\255\025\027\ \025\022\t, \n\020\007\027\024\023\021\031 \255\022\016\025\022, \033\032\ \031\b\025\031\016\022\032\031\021\020\025\022\027, \026\025\031\b\031\006\ \027\025\023\032\031\021\031\027 \022\024\024\f\027\030\031\021\020\025\022\ \027)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.025 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.8( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.015 Tc -0.035 Tw 9.004 0 Td ( \215\024\035\024\r\017\027\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \212\024\030\024\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\203.\200., \231\017\030\026\035\017\036\r)Tj /Span<>> BDC ( )Tj EMC (\217.\204.-\202., \216\026\035\026\235\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\026\031\001\026\027\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\207., \213\030\n\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\213.\202. \217\036\022\024\027\f\021\030\031\022\006\017\016)15( )]TJ 0.023 Tc 0.06 Tw -9.009 -1.2 Td (\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\020\024 \007\027\026 \023\024\f\035\036 \220\022\f\021\ \030\026\035\036\r\026\021\024\030\027\024\005 \002\030\033\001\027\024-\ \023\030\024\n\036\032\027\024\f\021\027\024\005 \220\022\f\021\017\030\023\ \026\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017: \027\024\r\ \024\036 \030\036\001\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.067 Tw 0 -1.2 TD [(\027\017\036 )0.5(\023\030\024\002\035\036\n\t )0.6(\(\030\036\031\035\034\021\026\021\t )0.5(\n\027\024\020\024\006\036\027\021\030\024\r\024\020\024 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\). )]TJ /T1_1 1 Tf -0.023 Tw 36.574 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.067 Tw [( )0.5(2026; )0.5(\021.)]TJ /Span<>> BDC ( )Tj EMC 12.232 0 Td [(25, )0.5(\223)]TJ /Span<>> BDC ( )Tj EMC 2.762 0 Td [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC 2.156 0 Td [(81\22691.)23( )]TJ -0.023 Tw -53.724 -1.2 Td (https://doi.org/10.33878/2073-7556-2026-25-1-81-91)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 459.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 47.6607 450.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0145 56.0378 Tm (81)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 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ORCID 0000-0003-22\ 94-7169)Tj 0.122 Tw T* (\207\017\030\033\022\024\r \210\035\036\020 \204\017\b\026\005\035\024\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \f\021\026\030\001\017\005 \027\026\031\004)Tj 0 Tw (-)Tj 0.238 Tw T* (\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\036\027\ \017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.318 Tw 0 -1.218 TD (\027\024\005 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\ \205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024)Tj 0 Tw (-)Tj 0.251 Tw 0 -1.218 TD (\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0002-1081-1793)Tj 0.471 Tw T* [(\215\036\030\001\017\027\026 )0.5(\202\027\026\f\021\026\f\017\016 )0.6(\213\r\020\036\027\034\036\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.737 0 Td [(\227 )0.5(\r\030\026\004 )0.5(\031\035\034\021\030\026)]TJ 0 Tw (-)Tj 0.931 Tw -14.737 -1.218 Td (\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \024\ \021\007\036\035\036\027\017\016 \031\035\034\021\030\026\r\031\022\024\ )Tj 0 Tw (-)Tj 0.561 Tw T* (\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \205\206\207\211 \253\ \203\204\230\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\ \017 )Tj 0.629 Tw T* (\017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0000-0002-4884-876X)Tj 0.127 Tw 23.244 23.138 Td (\204\031\007\030\024\r \202\027\007\030\036\005 \202\027\026\021\024\035\ \034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \r\036\007\031\013\017\005 \027\026)Tj 0 Tw (-)Tj 0.121 Tw T* (\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\ \026 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 )Tj 0.66 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\ \211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\024\035\024\ \020\017\017 )Tj 0.223 Tw T* [(\017\n\036\027\017 )0.5(\202.\203.)]TJ /Span<>> BDC ( )Tj EMC 5.253 0 Td [(\217\t\032\017\b\273 )0.6(\204\017\027\007\030\026\r\026 )0.5(\217\024\f\f\017\017; )0.6(\023\030\024\235\036\f\f\024\030 )]TJ 0.172 Tw -5.253 -1.218 Td [(\022\026\235\036\007\030\t \022\024\035\024\023\030\024\022\021\024\035\024\ \020\017\017 )0.5(\205\206\207\210\211 \212\215\210 \253\217\024\f\f\017\005\f\022\026\016\ )]TJ 0.427 Tw T* [(\n\036\007\017\006\017\027\f\022\026\016 )0.6(\026\022\026\007\036\n\017\016 )0.5(\027\036\023\030\036\030\t\r\027\024\020\024 )0.6(\023\030\024\235\036\f\f\017\024)]TJ 0 Tw (-)Tj 0.34 Tw 0 -1.218 TD (\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026\027\017\016\ \273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0002-1207-5988)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(T)35(imur V. Nik)-15.9(ishin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6991-1716)Tj T* [(Iv)-15(an V. K)25.1(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1778-0571)Tj 0 -1.218 TD [(Ale)-18(x)-10.9(ander Y)35(u. T)35(i)-24(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1636-8075)Tj 0 -1.218 TD [(Mar)-37(ia A. Igna)15.1(tenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-1182-419X)Tj 0 -1.218 TD [(Ev)-21(geny E. Zhar)-23.9(kov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3403-9731)Tj T* [(Ikr)-32(omzhon I. Dad)42.1(ashev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2294-7169)Tj T* [(Oleg M. Bir)-23.9(yukov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1081-1793)Tj T* [(P)30(er)-10(shina E. Anast)15.1(asia)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4884-876X)Tj T* [(Andr)-24(e)-10.9(y A. Mudr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1207-5988)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 456.9139 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.197 Tw 8 0 0 8 42.5197 444.0792 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(v)-15(an )0.5(Oostend)-16(or)-24(p)]TJ /Span<>> BDC ( )Tj EMC [(JY, )0.5(V)30(er)-24(k)-17(ade)]TJ /Span<>> BDC ( )Tj EMC 12.086 0 Td [(C, Han-Geur)-21.9(ts)]TJ /Span<>> BDC ( )Tj EMC 6.056 0 Td [(IJM, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(iga)15(t)-32(ion )]TJ 0.092 Tw -19.438 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(inter)-10(sphinc)-16(ter)-36.9(ic f)-28(istul)-15.9(a tr)-32.9(a)-17(c)-16(t \(LIFT\) for tr)-32.9(ans-sphinc)-16(ter)-36.9(ic cr)-24(ypt)17.1(o)]TJ 0 Tw (-)Tj 0.117 Tw 0 -1.25 TD [(gl)-16(andul)-15.9(ar anal f)-28(istul)-15.9(a: l)30(ong-ter)-16(m im)10(p)32(a)-17(c)-16(t on f)16(aecal cont)-32(inence. )]TJ /T1_4 1 Tf 0 Tw (BJS )Tj T* (Open.)Tj /T1_1 1 Tf 0.023 Tw [( 2024;8\(3\):zr)-32.9(ae025. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/bjsopen/zr)-33(ae025)]TJ 0 0 0 1 k /GS1 gs -0.019 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Madboul)35(y)]TJ /Span<>> BDC ( )Tj EMC [(KM, El S)-16(ha)-24(zl)35(y)]TJ /Span<>> BDC ( )Tj EMC [(W, A)-14(bbas)]TJ /Span<>> BDC ( )Tj EMC [(K)-25(S, e)-12(t al. L)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(inter)-9.9(sphinc)]TJ 0 Tw (-)Tj 0.041 Tw -1.296 -1.25 Td [(ter)-37(ic f)-28(istul)-15.9(a tr)-33(a)-17(c)-16(t ver)-10(sus mucosal ad)-17(v)-15(ancement fl)-16(ap in p)32(a)15(t)-32(ients wi)-24(t)-13(h )]TJ 0.008 Tc 0.349 Tw T* [(high tr)-32.7(anssphinc)-15.7(ter)-36.7(ic f)-27.7(istul)-15.7(a-in-ano: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25.3(r)-31.7(ospec)-15.7(t)-31.7(i)-15.7(ve r)-32.7(and)-15.7(omized)8( )]TJ 0 Tc 0 Tw T* [(tr)-37(ial. )]TJ /T1_4 1 Tf 0.085 Tw 2.319 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf [( 2014 O)-16(c)-16(t;57\(10\):1202\2261208. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.319 -1.25 Td (DCR.0000000000000194)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Zhang)Tj /Span<>> BDC ( )Tj EMC (L, Zhan)Tj /Span<>> BDC ( )Tj EMC [(C, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he inter)-10(sphinc)-15.9(ter)-37(ic f)-28(is)]TJ 0 Tw (-)Tj 0.092 Tw -1.296 -1.25 Td [(tul)-16(a tr)-33(a)-17(c)-16(t \(LIFT\) for high tr)-32.9(anssphinc)-16(ter)-37(ic f)-28(istul)-16(as: a)]TJ /Span<>> BDC ( )Tj EMC [(d)-16(ouble-center )]TJ 0.047 Tw T* [(r)-24(e)-12(tr)-31.9(ospec)-16(t)-32(i)-16(ve stud)17(y wi)-24(t)-13(h l)30(ong-ter)-16(m foll)30(o)-14(w-up. )]TJ /T1_4 1 Tf [(Ann Colop)46.1(roctol.)]TJ /T1_1 1 Tf ( 2025 )Tj 0.023 Tw T* [(F)10(eb;41\(1\):77\22683. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3393/a)-17(c.2024.00024.0003)]TJ 0 0 0 1 k /GS1 gs 0.033 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chase)Tj /Span<>> BDC ( )Tj EMC [(T)25(JG, Q)-16(uddus)]TJ /Span<>> BDC ( )Tj EMC [(A, Sel)30(v)-15(akumar)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)37(AAFT for com)10(ple)-18(x anal )]TJ -0.012 Tw -1.296 -1.25 Td [(f)-28(istul)-15.9(a: a)]TJ /Span<>> BDC ( )Tj EMC [(useful t)17(o)-16(ol, ho)-14(wever, cur)-23.9(e is unl)-31(ik)10(el)35(y. )]TJ /T1_4 1 Tf [(T)54(ech Colop)46(roctol)]TJ /T1_1 1 Tf (. 2021 )Tj 0.023 Tw T* [(O)-16(c)-16(t;25\(10\):1115\2261121. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-021-02486-9)Tj 0 0 0 1 k /GS1 gs -0.006 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(a T)45(or)-24(r)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(M, Go)-16(gl)-31(ia)]TJ /Span<>> BDC ( )Tj EMC [(M, Micar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35.1(ong ter)-16(m r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC [(v)-16(ideo\226)]TJ 0.302 Tw -1.296 -1.25 Td [(assisted anal f)-28(istul)-15.9(a tr)-23.9(ea)15(tment for com)10(ple)-18(x anal f)-28(istul)-16(a: ano)17(t)-13(h)]TJ 0 Tw (-)Tj 0.294 Tw T* [(er sha)15(t)-30(ter)-24(ed dr)-24(eam? )]TJ /T1_4 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf [( 2023 O)-16(c)-16(t;25\(10\):2017\2262023. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.16662)Tj 0 0 0 1 k /GS1 gs 0.076 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(de )0.5(l)-16(a )0.5(P)10(or)-22(t)-32(ill)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC 5.628 0 Td [(F, )0.5(Mu\361oz-Cr)-22(uzad)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC 7.423 0 Td [(MVD, )0.5(Maestr)-24(e)]TJ /Span<>> BDC ( )Tj EMC 5.669 0 Td [(MV, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.8 0 Td [(al. )0.5(Pl)-16(a)15(tele)-11.9(t-)]TJ 0.09 Tw -22.816 -1.25 Td [(r)-37(ich pl)-16(as)26(ma \(PRP\) ver)-9.9(sus f)-27.9(ibr)-37(in gl)35(ue in cr)-24(ypt)17(o)-16(genic f)-28(istul)-16(a\226in\226ano: )]TJ 0.302 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC 0.998 0 Td [(phase )0.5(III )0.5(single-center, )0.6(r)-33(and)-16(omized, )0.5(d)-16(ouble\226bl)-30.9(ind )0.5(tr)-37(ial. )]TJ /T1_4 1 Tf 24.498 0 Td [(Int )0.5(J )]TJ 0.276 Tw -25.495 -1.25 Td [(Colorectal )0.5(Dis)]TJ /T1_1 1 Tf [(. 2019 Jun;34\(6\):1113\2261119. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-)Tj T* (019-03296-0)Tj 0 0 0 1 k /GS1 gs 0.159 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC 3.476 0 Td [(\222.\202., )0.5(\025\031\034\n\017\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.026 0 Td [(\202.\204., )0.5(\025\024\030\024\035\017\022)]TJ /Span<>> BDC ( )Tj EMC 6.296 0 Td [(\200.\224., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.424 0 Td [(\f\024\026\r\021. )0.5(\215\036\030\r\t\005 )]TJ 0.322 Tw -21.518 -1.25 Td [(\024\023\t\021 \007\r\031\b\220\021\026\023\027\024\020\024 \035\036\004\ \036\027\017\016 )0.5(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\b )0.5(\f\r\017\013\036\005 \023\030\016\n\024\005 )]TJ -0.006 Tw T* (\022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \235\017\002\030\017\027\024\r\024\020\024 \022\035\ \036\016. )Tj /T1_4 1 Tf (\206\031\024\024\022\235\024\n\022\235 \255\r\032\025\020\f \b\020\024\023\ \032\031)Tj 0 Tw (-)Tj 0.002 Tc 0.35 Tw T* (\204\025\023\027\032\031\f\031\b\022\022, \b\027\033\020\023\031\f\031\b\ \022\022, \n\031\f\031\033\032\031\n\023\031\f\031\b\022\022. )Tj /T1_1 1 Tf -0.002 Tw (2017;27\(4\):102\226)Tj 0 Tc 0.312 Tw T* [(107. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-4376-2017-27-4-102-107)Tj 0 0 0 1 k /GS1 gs 0.312 Tw [( / F)10(r)-32(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC (S.A., )Tj 0.01 Tw T* [(K)25(uzminov)]TJ /Span<>> BDC ( )Tj EMC [(A.M., K)25(or)-32(ol)-30.9(ik)]TJ /Span<>> BDC ( )Tj EMC [(V.Y)35(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ir)-9.9(st e)-18(xper)-37(ience of)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o-st)15(a)-17(ge )]TJ 0.042 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-33(anssphinc)-16(ter)-36.9(ic f)-28(istul)-15.9(as of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-16(tum sing f)-28(ibr)-37(ingl)35(ue. )]TJ /T1_4 1 Tf 0.166 Tw T* [(R)19(os Zh Gastroenterol Gepatol K)18(olop)46(roktol)]TJ /T1_1 1 Tf (. 2017;27\(4\):102\226107. \(In )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-4376-2017-27-4-102-107)Tj 0 0 0 1 k /GS1 gs 0.161 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Her)-24(r)-23.9(er)-32(os)]TJ /Span<>> BDC ( )Tj EMC [(MD, Gar)-32(c)-24(ia-Ar)-23.9(r)-33(anz)]TJ /Span<>> BDC ( )Tj EMC [(M, Guad)42(al)-16(ajar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)10(ut)17(ol)30(o)-16(gous )]TJ 0.107 Tw -1.296 -1.25 Td [(e)-18(xp)32(anded adipose\226der)-37(i)-16(ved stem cells for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(ple)-17.9(x )]TJ 0.197 Tw T* [(cr)-24(ypt)17.1(o)-16(gl)-16(andul)-16(ar per)-37(ianal f)-28(istul)-15.9(as: a)]TJ /Span<>> BDC ( )Tj EMC [(phase III r)-33(and)-16(omized cl)-31(inical )]TJ 0.051 Tw 29.055 45 Td [(tr)-37(ial \(F)24(A)15(TT 1: f)-28(istul)-15.9(a ad)-17.1(v)-14.9(anced t)-13(her)-33(apy tr)-37(ial 1\) and l)30(ong-ter)-16(m ev)-15(al)35(u)]TJ 0 Tw (-)Tj T* [(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 0.26 Tw 2.919 0 Td [(Dis Colon R)21(ectum)]TJ /T1_1 1 Tf [(. 2012 Jul;55\(7\):762\226772. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.919 -1.25 Td (DCR.0b013e318255364a)Tj 0 0 0 1 k /GS1 gs 0.222 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\231\026\b\030\026\005)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \206\026\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\204., \206\026\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\224. \233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036\ \024\002\024)Tj 0 Tw (-)Tj 0.17 Tw -1.296 -1.25 Td (\f\027\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\005 \022\035\017\027\017\004\036\f\022\017\005 \024\023\ \t\021 \021\030\026\027\f\023\035\026\027\021\026\006\017\017 \022\031\035\ \034\021\031\030\t )Tj 0.162 Tw T* (\026\031\021\024\035\024\020\017\004\027\t\b \n\036\036\027\b\017\n\026\ \035\034\027\t\b \f\021\r\024\035\024\r\t\b \022\035\036\021\024\022 \032\ \017\030\024\r\024\005 \021\022\026\027\017 )Tj 0.161 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.868 0 Td [(\022\024\n\023\035\036\022\f\027\024\n )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\n )0.6(\035\036\004\036\027\017\017 )0.5(\220\022\f\021\030\026- )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.61 0 Td (\004\030\036\f\235\017\027\022\021\036\030)Tj 0 Tw (-)Tj 0.05 Tw -21.478 -1.25 Td (\027\t\b \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017\ . )Tj /T1_4 1 Tf (\001\031\021\031\024\023\022 \200\022\032\r\032\b\022\022. )Tj /T1_1 1 Tf 0 Tw (2012;20\(6\):60\22669. )Tj -0.018 Tw T* [(/ S)-16(hakhr)-33(ai)]TJ /Span<>> BDC ( )Tj EMC [(S.V., Gain Y)35(u.M., Gain)]TJ /Span<>> BDC ( )Tj EMC [(M.Y)35.1(u. E)35(xper)-37(iment)15(al just)-32(if)-28(ica)15(t)-32(ion and )]TJ 0.079 Tw T* [(f)-28(ir)-10(st cl)-31(inical e)-18(xper)-37(ience of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-33(anspl)-16(ant)15(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(cul)56.1(tur)-24(e of)]TJ /Span<>> BDC ( )Tj EMC [(aut)17(ol)30(o)-16(gical )]TJ 0.183 Tw T* [(adipose t)-32(issue mesenchymal stem cells in com)10(ple)-17.9(x sur)-32(gical tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.006 Tw T* (ment of)Tj /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-32.9(a- and tr)-33(ans-sphinc)-16(ter r)-24(ec)-16(tum f)-28(istul)-15.9(as. )]TJ /T1_4 1 Tf [(N)17(ov)13(osti Khirurgii.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2012;20\(6\):60\22669. \(In Russ.\).)Tj 0.015 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Or)-22(t)-32(iz)]TJ /Span<>> BDC ( )Tj EMC [(H, Mar)-24(zo)]TJ /Span<>> BDC ( )Tj EMC (J, Ciga)Tj /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omized cl)-30.9(inical tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC (anal )Tj 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(f)-27.5(is)0.5(t)0.5(ul)-15.5(a)0.5( pl)35.5(u)0.5(g v)0.5(er)-9.5(s)0.5(us)0.5( e)0.5(nd)-15.5(o)0.5(r)-23.6(e)0.5(c)-15.5(t)15.4(a)0.5(l)0.5( ad)-16.5(v)-14.5(an)0.5(ce)0.5(me)0.5(n)0.5(t f)0.5(l)-15.5(ap)0.5( f)0.5(or)0.5( t)-12.5(he)]TJ /Span<>> BDC 24.742 0 Td ( )Tj EMC [(t)0.5(r)-23.6(e)0.5(a)15.5(t)]TJ 0 Tc 0 Tw (-)Tj 0.003 Tc 0.35 Tw -24.742 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC [(high cr)-24.2(ypt)16.8(o)-16.2(gl)-16.3(andul)-16.2(ar f)-28.2(istul)-16.2(a in ano. )]TJ /T1_4 1 Tf (Br J Surg.)Tj /T1_1 1 Tf [( 2009)3( )]TJ 0 Tc 0.023 Tw T* [(Ma)15(y;96\(5\):608\226612. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.6613)Tj 0 0 0 1 k /GS1 gs 0.155 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhang)Tj /Span<>> BDC ( )Tj EMC [(Y, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (F, Zhao)Tj /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)-15(ideo\226assisted anal f)-28(istul)-15.9(a tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.182 Tw -1.796 -1.25 Td [(ment combined wi)-23.9(t)-13(h anal f)-28(istul)-15.9(a pl)35(ug for tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(hor)-10(seshoe )]TJ 0.001 Tc 0.35 Tw T* [(anal f)-28.3(istul)-16.2(a. )]TJ /T1_4 1 Tf [(J Int Med R)20.7(es.)]TJ /T1_1 1 Tf [( 2021 Jan;49\(1\):300060520980525.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/0300060520980525)Tj 0 0 0 1 k /GS1 gs 0.123 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-32(ossber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(SJ, Har)-24(r)-32.9(an)]TJ /Span<>> BDC ( )Tj EMC [(N, Bebing)17.1(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. Use of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he OVESC)13(O )]TJ 0.125 Tw -1.796 -1.25 Td [(OT)25(SC\256 p)25(r)-31.9(o)-16(c)-16(t)17(ol)30(o)-16(g)16(y cl)-30.9(ip for cl)30(osur)-23.9(e of)]TJ /Span<>> BDC ( )Tj EMC 15.193 0 Td [(f)-28(istul)-16(a\226in\226ano a)15(t )0.5(W)-16(i)-24(ts Donald )]TJ 0.109 Tw -15.193 -1.25 Td [(Gor)-24(d)-16(on Medical Centr)-24(e)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(single centr)-24(e e)-18(xper)-37(ience. )]TJ /T1_4 1 Tf (S Afr J Surg.)Tj /T1_1 1 Tf 0 Tw ( )Tj T* (2020;58\(2\):74\22677.)Tj 0.35 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-32(osst)]TJ /Span<>> BDC ( )Tj EMC 3.036 0 Td [(RL, )0.6(Jo)-16(os)]TJ /Span<>> BDC ( )Tj EMC 4.177 0 Td [(AK, )0.6(Ehni)]TJ /Span<>> BDC ( )Tj EMC 4.222 0 Td [(W, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.885 0 Td [(al. )0.5(P)34.9(r)-32(ospec)-16.1(t)-32(i)-16(ve )0.5(pil)29.9(o)17(t )0.5(stud)16.9(y )]TJ 0.045 Tw -16.116 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(anor)-24(ec)-16(t)15.1(al f)-27.9(istul)-16(a cl)30(osur)-24(e wi)-23.9(t)-13(h t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(OT)25(SC P)35(r)-31.9(o)-16(c)-16(t)17(ol)30(o)-16(g)16(y. )]TJ /T1_4 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2014;17:81\22686. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.12762)Tj 0 0 0 1 k /GS1 gs 0.13 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(or)-24(dholm-Car)-9.9(stensen)]TJ /Span<>> BDC ( )Tj EMC [(A, P)30(er)-24(r)-24(egaar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(H, Ha)-17(gen)]TJ /Span<>> BDC ( )Tj EMC [(KB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)-19(istul)-16(a )]TJ 0.163 Tw -1.796 -1.25 Td [(l)-16(aser cl)30(osur)-24(e \(F)-19(iL)-32(aC\252\) for f)-28(istul)-16(a-in-ano)]TJ /Span<>> BDC ( )Tj EMC [(\227 ye)-12(t ano)17(t)-13(her technique )]TJ 0.011 Tw T* [(wi)-24(t)-12.9(h 50% heal)-31(ing r)-32.9(a)15(tes? )]TJ /T1_4 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf ( 2021;36\(9\):1831\2261837. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-021-03915-9)Tj 0 0 0 1 k /GS1 gs 0.113 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(ilhelm)]TJ /Span<>> BDC ( )Tj EMC (A. A)Tj /Span<>> BDC ( )Tj EMC [(new technique for sphinc)-15.9(ter\226p)25(r)-24(eser)-31.9(v)-16(ing anal f)-28(is)]TJ 0 Tw (-)Tj -0.02 Tw -1.796 -1.25 Td [(tul)-16(a r)-24(ep)32(air using a)]TJ /Span<>> BDC ( )Tj EMC [(novel r)-33(adial emi)-23.9(t)-30(t)-32(ing l)-16(aser p)25(r)-32(obe. )]TJ /T1_4 1 Tf [(T)54(ech Colop)46(roctol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2011;15:445\226449. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-011-0766-5)Tj 0 0 0 1 k /GS1 gs 0.286 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Almughamsi)Tj /Span<>> BDC ( )Tj EMC [(AM, Z)10.1(ak)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(MK)-25(S, Alshanqi)-23.9(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(AM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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TD [(\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, )0.5(\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\035\026\021\036\030\026\035\034\027\024\n)Tj /Span<>> BDC ( )Tj EMC 18.049 0 Td (\227 \007\035\016 )Tj 0.08 Tw -18.049 -1.218 Td (\235\024\030\n\017\030\024\r\026\027\017\016 \035\024\f\022\031\021\026 \ \r\024\n\024\032\027\024 \024\006\036\027\017\021\034 \007\r\026 \r\026\ )Tj 0 Tw (-)Tj 0.097 Tw T* (\030\017\026\027\021\026, \f\023\030\026\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\r\026 \024\021 \r\027\031\021\030\036\027\027\036\020\024 \f\r\ \017\013\036\r\024\020\024 )Tj 0 Tw T* (\024\021\r\036\030\f\021\017\016;)Tj 0.255 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-12( )]TJ EMC 1 0 Td (\212\024\f\021\026\021\024\004\027\026\016 \r\026\f\022\031\035\016\030\017\ \026\006\017\016 \023\036\030\036\n\036\013\036\027\027\024\020\024 \035\ \024)Tj 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD [(\f\022\031\021\026: )0.5(\n\024\002\017\035\017\026\006\017\016 )0.6(\035\024\f\022\031\021\026 )0.6(\r\t\023\024\035\027\016\036\021\f\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.673 0 Td (\r\022\035\033)Tj 0 Tw (-)Tj -18.673 -1.218 Td (\004\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\017 \022\026\r\036\030\027\024\027\024\005 \021\022\026\027\017\ ;)Tj 0.02 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-247( )]TJ EMC 1 0 Td (\210\021\f\031\021\f\021\r\017\036 \f\r\016\017 \n\036\032\007\031 \026\ \027\026\021\024\n\017\004\036\f\022\024\005 \024\027\024\005 \220\022\f\ )Tj 0 Tw (-)Tj 0.011 Tw 0 -1.218 TD (\021\030\026\022\006\017\017 \035\024\f\022\031\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\004\026\021\024\004\027\t\n\017 \023\030\024\f\021\030\026\ \027\f\021\r\026\n\017, )Tj 0 Tw T* (\020\007\036 \r\024\n\024\032\027\024 \027\026\035\017\004\017\036 \020\ \027\024\005\027\t\b \026\021\036\022\024\r.)Tj 0.156 Tw -1 -1.218 Td (\215\024 \027\026\001\036\n\031 \n\027\036\027\017\033, \n\036\021\024\007\ \035\017\022\r\017\007\026\006\017\017 \r\027\031\021\030\036\027\027\036\ \020\024 )Tj 0.391 Tw 0 -1.218 TD (\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \023\036\ \030\036\n\036\013\036\027\027\t\n \035\026\021\036\030\026\035\034\027\t\ \n )Tj 0.039 Tw 0 -1.218 TD (\035\024\f\022\031\021\024\n \n\024\032\036\021 \030\026\f\f\n\026\021\030\ \017\r\026\021\034\f\016 \022\026\022 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024)Tj 0 Tw (-)Tj -0.055 Tw 0 -1.218 TD (\006\036\027\027\t\b \f\023\024\f\024\002\024\r \b\017\030\031\030\020\017\ \004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \253\f\035\024\032\ \027\t\b\273 )Tj -0.001 Tw T* (\023\030\016\n\024\022\017\001\036\004\027\t\b \f\r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\005 \035\024\022\026\035\017\026\006\017\036\005 \020\027\ \024\005)Tj 0 Tw (-)Tj 0.229 Tw T* (\027\024\020\024 \023\030\024\006\036\f\f\026, \027\036\f\n\024\021\030\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \036\020\024 \220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.208 Tw T* [(\027\024\f\021\034 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\007\024\f\021\024\r\036\030\027\024 )0.5(\b\031\032\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.637 0 Td (\027\026\035\017\004\017\017 )Tj 0.133 Tw -18.637 -1.218 Td [(\020\027\024\005\027\024-\r\024\f\023\026\035\017\021\036\035\034\027\t\b\ )0.7(\026\021\036\022\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.705 0 Td (\n\036\032\f\235\017\027\022\021\036\030\027\024\n, )Tj 0.442 Tw -14.705 -1.218 Td (\017\001\017\024\026\027\026\035\034\027\024\n, \023\036\035\034\r\017\024\ \030\036\022\021\026\035\034\027\024\n \023\030\024\f\021\030\026\027\f\021\ \r\026\b. )Tj 0.286 Tw T* (\215\030\017\027\016\021\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \022\024\027\006\036\ \023\006\017\016 \b\017\030\031\030\020\017\017 )Tj 0.447 Tw T* (\253\f\035\024\032\027\t\b\273 \023\030\016\n\024\022\017\001\036\004\027\ \t\b \f\r\017\013\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 )Tj 0.37 Tw T* (\020\027\024\005\027\024\020\024 \023\030\024\006\036\f\f\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\004\026\021\024\004\027\t\b )0.5(\023\030\024\f\021\030\026\027\f\021\r\026\b )]TJ -0.004 Tw T* (\023\030\036\007\023\024\035\026\020\026\036\021 \n\027\024\020\024\220\021\ \026\023\027\024\036 \035\036\004\036\027\017\036, \020\007\036 \023\036\ \030\r\t\n \220\021\026)Tj 0 Tw (-)Tj 0.06 Tw T* [(\023\024\n )0.5(\r\t\023\024\035\027\016\036\021\f\016 )0.6(\r\f\022\030\t\021\017\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.42 0 Td [(\007\030\036\027\017\030\024\r\026\027\017\036 )0.6(\020\027\024\005\027\t\b )]TJ 0.062 Tw -12.42 -1.218 Td (\026\021\036\022\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\036 \027\036\024\002\b\024\007\017\n \r\t\002\024\030 \n\ \036\021\024\007\026 \030\026\007\017\022\026\035\034)Tj 0 Tw (-)Tj 0.101 Tw T* (\027\024\020\024 \035\036\004\036\027\017\016 \f\r\017\013\026 \023\030\016\ \n\024\005 \022\017\001\022\017. \221\024 \036\f\021\034, \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.333 Tw T* (\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \023\026\006\017\036\027\ \021\t \253\024\002\030\036\004\036\027\t\273 \027\026, \n\017\027\017)Tj 0 Tw (-)Tj 0.14 Tw T* (\n\031\n, \007\r\036 \024\023\036\030\026\006\017\017. \215\030\036\007\035\ \024\032\036\027\027\t\005 \032\036 \027\026\n\017 \f\023\024\f\024\002 \ )Tj 0.056 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\n\017\027\017\n\026\035\034\027\024\005 \021\030\026\r\n\036 )0.5(\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 )0.5(\(\023\024 \f\031\021\017, )]TJ 0.087 Tw T* (\021\030\026\027\f\026\027\026\035\034\027\t\005 \220\021\026\023 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\033 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\036\004\036\027\017\016 \023\024\f\035\036 \023\036\030\r\024\005 \024\023\ \036\030\026)Tj 0 Tw (-)Tj 0.215 Tw T* (\006\017\017 \023\030\026\022\021\017\004\036\f\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\t \023\026\006\017\036\027\021\024\r \f\024 \253\ \f\035\024\032)Tj 0 Tw (-)Tj 0.203 Tw T* [(\027\t\n\017\273 )0.5(\f\r\017\013\026\n\017 \023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.5(\(50% \023\026\006\017\036\027\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj -0.054 Tw -21.11 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \026\021\036\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036; )Tj 0.105 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (52,4% \f\035\031\004\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\001\017\024\026\027\026\035\034\027\024\005 \035\024\022\026\035\017\ \026\006\017\017 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\b\017\030\031\030\020\017\017 \f\035\024\032\027\t\b \f\r\017\ )Tj 0 Tw (-)Tj T* (\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 140.2858 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.274 Tw 10 0 0 10 70.8661 115.9298 Tm (\217\036\031\035\034\021\026\021\t \027\026\001\036\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016 \023\030\024\007\036\n\024\027\f\021\030\017\ \030\024)Tj 0 Tw (-)Tj 0.113 Tw T* (\r\026\035\017, \004\021\024 \n\036\021\024\007 \035\017\022\r\017\007\026\ \006\017\017 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 )Tj 0.059 Tw T* (\024\021\r\036\030\f\021\017\016 \023\036\030\036\n\036\013\036\027\027\t\ \n \035\026\021\036\030\026\035\034\027\t\n \035\024\f\022\031\021\024\n\ \023\024)Tj 0 Tw (-)Tj -0.072 Tw T* (\r\024\035\016\036\021 \024\007\027\024\220\021\026\023\027\024 \035\017\ \022\r\017\007\017\030\024\r\026\021\034 \253\f\035\024\032\027\t\036\273\ \f\r\017\013\017 )Tj 0.136 Tw 23.244 64.543 Td [(\023\030\016\n\024\005 \022\017\001\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(80% \027\026\002\035\033\007\036\027\017\005. \212\r\031\b\220\021\026\023\ \027\024\036 )0.5(\b\017)]TJ 0 Tw (-)Tj 0.089 Tw 0 -1.218 TD (\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\036,\ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\t\n \023\030\017)Tj 0 Tw (-)Tj -0.01 Tw 0 -1.218 TD (\n\036\027\036\027\017\036\n \n\036\021\024\007\026 \214\215\214 \023\024\ \r\024\035\016\036\021 \007\024\002\017\021\034\f\016 \017\035\036\004\ \036\027\017\016 )Tj 0 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (96,7% \023\026\006\017\036\027\021\024\r.)Tj 0.427 Tw 0 -1.218 TD (\211\004\017\021\t\r\026\016 \n\017\027\017\n\026\035\034\027\t\005 \030\ \017\f\022 \030\026\r\017\021\017\016 \023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 0.813 Tw 0 -1.218 TD [(\030\026\006\017\024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005, )0.6(\027\017\022\031\033 )0.6(\017\027\021\036\027\f\017\r\027\024\f\021\034 )]TJ 0.835 Tw 0 -1.218 TD (\002\024\035\036\r\024\020\024 \f\017\027\007\030\024\n\026, \024\021\f\031\ \021\f\021\r\017\036 \024\021\030\017\006\026\021\036\035\034\027\024\020\ \024 )Tj 0.463 Tw 0 -1.218 TD (\r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\024\036 \f\024\f\021\024\ \016\027\017\036 \026\027\026\035\034\027\024)Tj 0 Tw (-)Tj 0.532 Tw T* [(\020\024 )0.5(\f\235\017\027\022\021\036\030\026, )0.6(\n\036\021\024\007 )0.5(\214\215\214 )0.5(\016\r\035\016\036\021\f\016 )0.6(\002\036\024\023\026\f\027\t\n )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\021\030\026\r\n\026\021\017\004\027\t\n.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.389 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \215)8.4(\r)7.1(\030)2.7(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.01 Tc 0.01 Tw T* [(\001)4.6(\022)-2.3(\n)2.7(\022\213\022)-2.7(\025)]TJ /Span<>> BDC 3.69 0 Td ( )Tj EMC [()55(.)18.5(\211)14.4(.)]TJ /T1_0 1 Tf 0 Tc 0.716 Tw -3.69 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.8(\024)-11(\021)-17.6(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.01 Tc 0.726 Tw [( \001)4.6(\022)-2.3(\n)2.8(\022\213\022)-2.8(\025)]TJ /Span<>> BDC 19.526 0 Td ( )Tj EMC [()55(.)18.5(\211)14.3(.)-2.2(,)-10( )]TJ 0 Tc 0 Tw -19.526 -1.218 Td [(\215)8.4(\r)7.1(\030)2.7(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)7.8(, \004)8.8(\027)-0.9(\032)5.9(\213)9.6(\022)7.2(\025)9.6(\020)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)30.3(\036)22.8(.)7.8(, )]TJ /T1_0 1 Tf (\212\026\007\026\001\036\r \230.\230.)Tj 0.002 Tc -0.002 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \215)8.4(\r)7.1(\030)2.7(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)7.8(, \001)14.6(\022)7.7(\n)12.7(\022)9.6(\213)9.6(\022)7.3(\025)]TJ /Span<>> BDC ( )Tj EMC [()65(.)28.5(\211)24.3(.)]TJ /T1_0 1 Tf 0.126 Tw -7.694 -1.218 Td [(\222)17.2(\021)-21.5(\026)-11.8(\021)-17.7(\017)-2.4(\f)-36(\021)-17.7(\017)4.6(\004)-8.2(\036)-10.4(\f)-1.6(\022)-19.1(\026)-21.1(\016 \024)-11.8(\002)3(\030)-11.3(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \007)-20.1(\026\027)1.7(\027)1.7(\t)-12.8(\b)-9.3(:)]TJ /T1_3 1 Tf -0.007 Tc 0.133 Tw [( \002)16.2(\b\025)2.5(\020)-5.2(\023)-3(\027)-4.7(\025)3.8(\n)2.7(\031)]TJ /Span<>> BDC 19.802 0 Td ( )Tj EMC [(\215)12.4(.\003)-9.3(.)0.8(,)-7( )]TJ -0.01 Tc 0.01 Tw -19.802 -1.218 Td [(\001)4.6(\022)-2.3(\n)2.7(\022\213\022)-2.7(\025)]TJ /Span<>> BDC 3.69 0 Td ( )Tj EMC [()55(.)18.5(\211)14.4(.)-2.2(,)-10( \234)5.1(\020)-8.2(\032)-4.1(\n\031\021)]TJ /Span<>> BDC 5.23 0 Td ( )Tj EMC [(\036)12.8(.)20.3(\036)12.9(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -8.92 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf 0.839 Tw [( \215)8.4(\r)7.1(\030)2.8(\032\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.9(, \202)15.6(\031)-0.8(\024\023)6.9(\020)1.9(\032\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.9(.)28.5(\211)24.3(.)7.8(, )]TJ -0.01 Tc 0.01 Tw T* [()42.8(\022)-2.3(\023)-5.9(\031\021)]TJ /Span<>> BDC 2.519 0 Td ( )Tj EMC [(\003)-12.3(.)17.5(\224)16.7(.)-2.2(,)-10( \221)4.6(\022)-5.3(\032)-4.6(\005)-4.7(\n\031\021)]TJ /Span<>> BDC 6.017 0 Td ( )Tj EMC [(\217)17.6(.)10.1(\215)9.5(.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -8.536 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.194 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.4(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.2(r)2.4(o)-0.6(v)33.7(, )]TJ -0.008 Tc 0.008 Tw T* [(T)-10.7(im)-2.8(u)-1.8(r)]TJ /Span<>> BDC 2.199 0 Td ( )Tj EMC [(V)45.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(Nik)-26.4(i)3(s)1.6(h)-1.8(in)]TJ /T1_0 1 Tf 0 Tc 1.014 Tw -3.154 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj -0.086 Tw -15.798 -1.218 Td [(T)-2.7(i)8.4(m)5.2(u)6.1(r)]TJ /Span<>> BDC ( )Tj EMC 2.346 0 Td [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8(i)7.9(k)-18.5(i)11.1(s)9.6(h)6.2(i)8.4(n)-6(, A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.5(d)5.2(r)2.4(o)-0.6(v)33.6(, A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.3(i)6(a E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-1.7(r)-10.7(s)9.6(h)6.2(i)8.4(n)4.8(a)-14(, )]TJ -0.002 Tc 0.002 Tw -2.346 -1.218 Td [(I)4.1(k)0.9(ro)-1.6(m)6.8(z)6.1(ho)-1.6(n)]TJ /Span<>> BDC 4.161 0 Td ( )Tj EMC (I.)Tj /Span<>> BDC 0.864 0 Td ( )Tj EMC [(D)-5.2(a)-6.5(da)-4.9(s)7.6(he)-6(v)]TJ /T1_0 1 Tf -0.052 Tc 0.052 Tw -5.025 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 5.233 0 Td [( A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.2(r)2.4(o)-0.6(v)33.6(, T)-2.6(i)8.4(m)5.2(u)6.1(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8.1(i)7.9(k)-18.5(i)11(s)9.6(h)6.2(i)8.4(n)]TJ /T1_0 1 Tf -0.007 Tc 1.28 Tw -5.233 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.273 Tw 10.361 0 Td [( M)5.2(ar)-35.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(I)10.1(g)1.8(n)4.9(a)-4.9(t)2.8(e)-2.6(n)7.5(k)12.9(o)-3.7(, )]TJ 0 Tw -10.361 -1.218 Td [(T)-2.7(i)8.4(m)5.2(u)6.1(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8(i)7.9(k)-18.5(i)11.1(s)9.6(h)6.1(i)8.5(n)-6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)1.8(h)4.8(ar)-2.5(k)12.9(o)-0.6(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.837 Tw 3.238 0 Td [( A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.4(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.3(r)2.4(o)-0.6(v)33.6(, I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)3.3(s)-10.7(t)2.3(ar)2.4(e)-4(v)33.6(, )]TJ -0.005 Tc 0.005 Tw -3.238 -1.218 Td [(A)-1.4(le)-33.6(xa)-5.8(n)-5.6(d)-6(e)-6.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC [(Y)28.7(u)2.7(.)]TJ /Span<>> BDC 1.43 0 Td ( )Tj EMC [(T)-7.7(i)-4.1(t)-3.6(o)-5.6(v)28.6(,)-5( O)-12.3(le)-8.5(g)]TJ /Span<>> BDC 4.261 0 Td ( )Tj EMC (M.)Tj /Span<>> BDC 1.172 0 Td ( )Tj EMC [(Bi)4.4(r)-45.2(y)-1.2(uk)7.9(o)-5.5(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -10.747 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 1.391 Tw T* (\203\017\022\017\001\017\027 \221\017\n\031\030 \200\035\026\007\017\n\017\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.944 Tw T* [(\022\024\035\024\023\030\024\022\021\024\035\024\020, )0.6(\205\206\207\211 )0.5(\253\203\204\230\037 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )]TJ 0.629 Tw T* (\017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0000-0001-6991-1716)Tj 0.01 Tc 0.391 Tw T* (\025\024\f\021\026\030\036\r \230\r\026\027 \200\026\f\017\035\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \030\031\022\024\r\024\007\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.591 Tw T* [(\021\036\035\034 )0.5(\024\021\007\036\035\026 )0.5(\024\002\013\036\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.222 0 Td [(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 )0.5(\022\024\035\024)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.339 Tw -11.222 -1.218 Td (\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\ \230\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\ \n\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.452 Tw T* (\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC [(\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; \023\030\024\235\036\f\f\024\030)10( )]TJ 0.062 Tw T* [(\022\026\235\036\007\030\t \022\024\035\024\023\030\024\022\021\024\035\024\ \020\017\017 \205\206\207\210\211 \212\215\210 \253\217\024\f\f\017\005\f\ \022\026\016)10( )]TJ 0.283 Tw T* (\n\036\007\017\006\017\027\f\022\026\016 \026\022\026\007\036\n\017\016 \ \027\036\023\030\036\030\t\r\027\024\020\024 \023\030\024\235\036\f\f\017\ \024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.23 Tw T* [(\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026\027\017\016\ \273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID)10( )]TJ -0.01 Tw T* (0000-0002-1778-0571)Tj 0 Tc 0.171 Tw T* (\221\017\021\024\r \202\035\036\022\f\026\027\007\030 \224\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \020\035\026\r\027\t\005 \027\026\031\004)Tj 0 Tw (-)Tj 0.238 Tw T* (\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\036\027\ \017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.318 Tw T* (\027\024\005 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\ \205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0000-0002-1636-8075)Tj 0.221 Tw T* (\230\020\027\026\021\036\027\022\024 \204\026\030\017\016 \202\027\007\030\ \036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \f\023\036\006\017\026\035\017\f\021 \024\021\007\036\035\026 )Tj 0.045 Tw T* (\023\035\026\027\017\030\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\017\026\006\017\017 \027\026\031\004\027\t\b \017\f\ \f\035\036\007\024\r\026\027\017\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.19 56.0378 Tm (78)Tj ET endstream endobj 1165 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.285 Tw 10 0 0 10 42.5197 517.8039 Tm (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.491 0 Td [(\030\036\031\035\034\021\026\021 )0.6(\023\030\017\n\036\027\036\027\017\016 )0.5(\214\215\214, )0.5(\017\035\036\004\036\027\017\016 )0.5(\031\007\026\035\024\f\034 )]TJ 0.236 Tw -1.491 -1.218 Td [(\007\024\002\017\021\034\f\016 )0.6(\002\024\035\036\036 )0.5(\004\036\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.99 0 Td [(60% )0.5(\021\026\022\024\020\024 )0.5(\030\024\007\026 )0.6(\023\026\006\017\036\027\021\024\r )]TJ 0 Tw -9.99 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (9\).)Tj 0.172 Tw 0 -1.218 TD [(\217\036\006\017\007\017\r )0.5(\026\002\024\035\036\r\026\027\017\016 )0.5(\r\t\016\r\035\036\027 \r)]TJ /Span<>> BDC ( )Tj EMC [(12/60 )0.5(\(20,0%\) \027\026)]TJ 0 Tw (-)Tj 0.16 Tw T* (\002\035\033\007\036\027\017\016\b. \230)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \024\021 \007\026\035\034\027\036\005\001\036\020\024 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 )Tj 0.024 Tw T* (\035\036\004\036\027\017\016 \024\021\022\026\026\035\017\f\034 2/12 \(\ 16,7%\) \002\024\035\034\027\t\b. \215\024\r\021\024\030\027\024 )Tj 0.439 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\036 4\2269)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \002\t\035\017 \024\023\036\030\017\030\024\r\026\ \027\t )Tj -0.012 Tw T* (10/60 \(16,7%\) \023\026\006\017\036\027\021\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (8/10 \(80,0%\) \f\035\031\004\026\016\b \r\t)Tj 0 Tw (-)Tj 0.079 Tw T* (\023\024\035\027\036\027\024 \023\030\024\r\036\007\036\027\017\036 \007\ \030\036\027\017\030\031\033\013\036\005 \035\017\020\026\021\031\030\t.\ \212\026\035\036\036, )Tj 0.514 Tw T* (\031\004\017\021\t\r\026\016 \007\017\f\021\026\035\034\027\031\033 \n\017\ \020\030\026\006\017\033 \f\r\017\013\036\r\024\020\024 \b\024\007\026 )Tj 0.314 Tw T* (\023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \035\026\021\036\ \030\026\035\034\027\024\020\024 \035\024\f\022\031\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.113 Tw T* (\007\031\033\013\036\005 \n\017\020\030\026\006\017\017 \035\017\020\026\ \021\031\030\t, \r\024 \r\f\036\b 8 \027\026\002\035\033\007\036\027\017\ \016\b )Tj 0.027 Tw T* (\r\t\023\024\035\027\036\027\024 \024\023\036\030\026\021\017\r\027\024\036\ \r\n\036\001\026\021\036\035\034\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \017\f)Tj 0 Tw (-)Tj 0.037 Tw T* (\f\036\004\036\027\017\016 \f\r\017\013\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 \022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (1/10 \(10,0%\) \f\035\031)Tj 0 Tw (-)Tj -0.033 Tw T* (\004\026\036 \f\r\017\013 \031\f\023\036\001\027\024 \035\017\022\r\017\007\ \017\030\024\r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \023\036\030\036\r\016)Tj 0 Tw (-)Tj 0.021 Tw T* (\022\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036. )Tj 0.167 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (1/10 \(10,0%\) \027\026\002\035\033\007\036\027\017\017, \023\024\r\021\024\ \030\027\024 \017\f\023\024\035\034\024\r\026\027 )Tj 0.029 Tw T* (\n\036\021\024\007 \023\036\030\036\n\036\013\036\027\017\016 \214\215\214\ \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\n \030\036\031\035\034\021\ \026)Tj 0 Tw (-)Tj T* (\021\024\n \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 262.0659 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.128 Tw 10 0 0 10 42.5197 237.7099 Tm [(\215\030\024\021\024\021\017\023\024\n )0.5(\007\035\016 \n\036\021\024\007\026 )0.5(\214\215\214 \016\r\035\016\036\021\f\016 )0.5(\027\026\017\002\024\035\036\036 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.037 Tw T* (\023\031\035\016\030\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\023\024\f\024\002\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 )Tj 0.187 Tw T* (\035\036\004\036\027\017\016 \253\f\035\024\032\027\t\b\273 \f\r\017\013\ \036\005 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\016)Tj 0 Tw (-)Tj 0.045 Tw T* (\n\024\022\017\001\036\004\027\t\005 \(\023\030\024\022\f\017\n\026\035\034\ \027\t\005\) \035\024\f\022\031\021, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.135 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n, \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n\031 \n\027\036\027\017\033, \031)Tj /Span<>> BDC ( )Tj EMC (\035\026\021\036\030\026\035\034\027\024\020\024 \023\030\016)Tj 0 Tw (-)Tj 0.192 Tw T* (\n\024\022\017\001\036\004\027\024\020\024 \035\024\f\022\031\021\026 \r\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\027\t\b \022\035\017\027\017\004\036\ \f\022\017\b )Tj 0 Tw T* (\f\017\021\031\026\006\017\016\b \036\f\021\034 \030\016\007 \023\030\036\ \017\n\031\013\036\f\021\r:)Tj 0.109 Tw T* (\251)Tj /Span<>> BDC [( )-158( )]TJ EMC 1 0 Td [(\204\036\021\024\007 \002\024\035\036\036 \023\030\024\f\021 \021\036\b\027\ \017\004\036\f\022\017, )0.5(\021\026\022 \022\026\022 \253\031\020\024\035 \026\021\026)]TJ 0 Tw (-)Tj 0.265 Tw T* (\022\017 \b\017\030\031\030\020\026\273 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\002\017\035\017\026\006\017\017 \035\026\021\036\030\026\035\034\ \027\024\020\024 \035\024)Tj 0 Tw (-)Tj 0.103 Tw T* [(\f\022\031\021\026 \030\026\f\023\024\035\026\020\026\036\021\f\016 \f\031\ \013\036\f\021\r\036\027\027\024 )0.5(\007\017\f\021\026\035\034\027\036\036, \004\036\n )]TJ 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\022\f\017\n\026\035\034\027\024\n \035\024\f\022\031\021\036\ ;)Tj 0.008 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-259( )]TJ EMC 1 0 Td [(\200\024\n\024\032\027\024\f\021\034 )0.5(\r\t\002\024\030\026 \027\026\017\002\024\035\036\036 )0.5(\024\023\021\017\n\026\035\034\027\024\005 \021\022\026\027\017 )]TJ 0.06 Tw T* [(\007\035\016 )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 \035\024\f\022\031\021\026.\ )0.5(\221\026\022, \036\f\035\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\022\f\017)Tj 0 Tw (-)Tj 0.075 Tw T* (\n\026\035\034\027\024\n \035\024\f\022\031\021\036 \027\036\021 \026\035\ \034\021\036\030\027\026\021\017\r\t \024\021\007\036\035\031 \023\030\016\ \n\024\005 )Tj ET q 274.961 483.166 221.102 241.171 re W n q /GS0 gs 221.1023475 0 0 241.2680546 274.9606228 483.0686982 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.073 Tw 9 0 0 9 274.9606 472.3656 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( ROC-\n\032\022\021\020\t \016\020\021\022\024\022\026\031\024\023\022 \032\ \027\006\022\030\022\021\020 \205\004\202 \031\023 \022\025)Tj 0 Tw (-)Tj 0.148 Tw 0 -1.2 TD (\030\027\n\024\020 \026\020\024\024\013 \023\027\f\020. AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,09 \(95% \220\002 0,53; 0,88\), )Tj 0.056 Tw T* (\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,032, \023\031\007\n\020 \031\023\024\027\007\n\022 \024\031\031\023\021\ \027\023\024\023\021\r\027\023 30,7 \n\b/\026\262. \232\r\021)Tj 0 Tw (-)Tj 0.059 Tw T* (\024\023\021\022\023\027\f\017\025\031\024\023\017)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66,7% \(95% \220\002 34,9; 90,1%\). \205\033\027\006\022\203\022\007)Tj 0 Tw (-)Tj 0.079 Tw T* (\025\031\024\023\017)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (81,3% \(95% \220\002 67,4; 91,1%\). \004\037\004\206)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (47,1% \(95% )Tj 0 Tw T* (\220\002 23,0; 72,2%\). \004\037\217\206)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90,7% \(95% \220\002 77,9; 97,4%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.086 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( R)19(OC is the)]TJ /Span<>> BDC ( )Tj EMC [(cur)-42(v)13(e of)]TJ /Span<>> BDC ( )Tj EMC [(AF recur)-15.9(rence v)13(ersus body mass )]TJ 0.079 Tw T* [(inde)-15(x. A)29(UC)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0.09 \(95% CI 0.53; 0.88\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.032, cut-)Tj 0.16 Tw T* [(of)-40(f point cor)-16(responds tok)15(g/m2. TP)66(R)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66.7% \(95% CI 34.9; )Tj -0.02 Tw T* [(90.1%\). FP)66(R)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(81.3% \(95% CI 67.4; 91,1%\). PPV \(positiv)13(e p)46(re)]TJ 0 Tw (-)Tj 0.079 Tw T* [(dictiv)13(e )0.5(v)16(alue\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(47.1% )0.5(\(95% CI )0.5(23.0; 72.2%\). NPV )0.5(\(neg)12(ativ)13(e )]TJ 0 Tw T* [(p)46(redictiv)13.1(e v)16(alue\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90.7% \(95% CI 77.9; 97.4%\))Tj ET q 274.961 122.57 221.102 220.492 re W n q /GS0 gs 221.1023475 0 0 220.6222255 274.9606228 122.4394817 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tw 9 0 0 9 274.9606 111.7701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( \020\n\023\022\n\020 \030\020\f\017\025\027\235\213\027\b\031 \f\027\007\ \027\025\022\t )0.5(\033\020\006\022\027\025\023\031\021 \024)]TJ /Span<>> BDC ( )Tj EMC (\032\027)Tj 0 Tw (-)Tj T* (\006\022\030\022\021\031\026 \205\004\202 \033\031\024\f\027 \033\032\022\ \026\027\025\027\025\022\t \f\020\023\027\032\020\f\017\025\031\b\031 \f\ \031\024\n\r\023\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.046 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( Manag)12(ement strategy for patients with recur)-16(rent ano)]TJ 0 Tw (-)Tj T* [(rectal f)-42.9(istula af)-45.9(ter lateral f)-21.9(lap p)46.1(rocedure)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.005 Tw -25.827 72.346 Td [(\020\004\206\f\t\204\004 )0.5(9.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(\211\f\022\t\025\022\027 )0.5(\025\020\f\022\007\022\t \b\025\031\235\025\013\200 )0.5(\016\020\023\027\n\031\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 20.248 0 Td [(\022\200 )0.5(\f\031\n\020\f\022)]TJ 0 Tw (-)Tj 0.094 Tw -20.248 -1.2 Td (\016\020\006\022\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\204\203\203\027\n\023\022\021\025\031\024\023\017 \026\027\023\031\030\020\ \035\004\035 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\022 \024\f\031\255)Tj 0 Tw (-)Tj 0 -1.2 TD (\025\013\200 \024\021\022\212\027\235 \033\032\t\026\031\235 \n\022\213\n\ \022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.102 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 9.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.075 Tw 3.374 0 Td [( I)2.3(m)-1(p)-6.3(a)-9.2(c)-32.4(t o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-3(u)1.6(r)-9.1(u)-1.5(le)-7(n)-0.6(t c)2.8(o)-5.3(l)-3.8(le)-10.9(c)-32.4(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-5.1(n)-4.8(d t)-10.6(h)-2.4(e)-6.2(i)4.9(r l)-1.6(o)-12.4(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n o)-3.9(n )]TJ 0 Tw -3.374 -1.2 Td [(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)6.7(u)-3.7(c)2.3(c)2.9(e)-22(s)-10.5(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(L)-5.6(R)6.8(F i)3.9(n c)2.8(o)-4(m)-1(p)-4.9(le)-32.3(x a)-5.1(na)-4.5(l \243)6.4(s)-14.8(t)-1.1(u)-1.6(l)-1(a)-7.2(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 682.781 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 682.781 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 263.872 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 661.7118 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 661.7118 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 650.2505 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 650.2505 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 638.7892 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 638.7892 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 627.3279 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 627.3279 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 615.8666 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 604.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 615.8666 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 604.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 604.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 604.4054 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 593.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 604.4054 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 593.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 593.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 592.9441 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 581.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 592.9441 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 581.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 581.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 581.4828 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 570.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 581.4828 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 570.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 570.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 570.0215 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 558.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 570.0215 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 558.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 558.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 558.5602 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 547.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 558.5602 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 547.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 547.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 547.0989 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 184.502 547.0989 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 54.2607 674.1464 Tm (\025\004\f\t\201\t\r, \216\004\006\004\220\003\r\006 \t)Tj /Span<>> BDC ( )Tj EMC (\f\002\220\004\f\t\213\004\204\t\235 )Tj 3.75 -1.2 Td (\n\b\002\005\b\013\216 \213\004\003\r\220\002)Tj 13.099 1.2 Td (\021\002\f-\002 \013\f\r\201\r\b\b\013\216 )Tj -0.124 -1.2 Td (\212\004\204\t\r\b\003\002 \()Tj /T1_5 1 Tf (n)Tj /T1_3 1 Tf (/N\(%\)\))Tj /T1_1 1 Tf -17.807 -1.433 Td (\206\027\024\005\027\t\036 \026\021\036\022\017)Tj 19.393 0 Td (28/39)Tj /Span<>> BDC ( )Tj EMC (\(71,8%\))Tj -19.393 -1.433 Td (\204\027\024\032\036\f\021\r\036\027\027\t\036 \020\027\024\005\027\t\036\ \026\021\036\022\017)Tj 19.393 0 Td (15/23)Tj /Span<>> BDC ( )Tj EMC (\(65,2%\))Tj -19.393 -1.433 Td (\204\036\032\f\235\017\027\022\021\036\030\027\t\005 \026\021\036\022)Tj 19.893 0 Td (4/8)Tj /Span<>> BDC ( )Tj EMC (\(50,0%\))Tj -19.893 -1.433 Td (\230\001\017\024\026\027\026\035\034\027\t\005 \026\021\036\022)Tj 19.393 0 Td (11/21)Tj /Span<>> BDC ( )Tj EMC (\(52,4%\))Tj -19.393 -1.433 Td (\215\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\005 \026\021\ \036\022)Tj 19.893 0 Td (4/9)Tj /Span<>> BDC ( )Tj EMC (\(44,4%\))Tj -19.893 -1.433 Td (\217\036\021\030\024\030\036\022\021\026\035\034\027\t\005 \026\021\036\ \022)Tj 19.643 0 Td (8/11)Tj /Span<>> BDC ( )Tj EMC (\(72,7%\))Tj -19.643 -1.433 Td (\215\024\007\f\035\017\017\f\021\t\005 \026\021\036\022)Tj 20.314 0 Td (\275\(50,0%\))Tj -20.314 -1.433 Td (\200\027\031\021\030\017\f\021\036\027\024\004\027\t\005 \026\021\036\022\ )Tj 19.893 0 Td (1/3)Tj /Span<>> BDC ( )Tj EMC (\(33,3%\))Tj -19.893 -1.433 Td (\215\024\007\022\024\032\027\t\005 \026\021\036\022)Tj 19.393 0 Td (13/16)Tj /Span<>> BDC ( )Tj EMC (\(81,3%\))Tj -19.393 -1.433 Td (\003\026\021\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005 \023\036\030\ \036\020\024\030\024\007\022\036)Tj 19.985 0 Td (5/5)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.9518 56.0378 Tm (77)Tj ET endstream endobj 1166 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   {!A16QUbu"#%23CRSTa $&'()*45789:BDEFGHIJVWXYZcdefghijqrstvwxyz {!1AQ"q2Ra4B3CSrst #$%&'()*56789:DEFGHIJTUVWXYZbcdefghijuvwxyz?0Ъ0i$nWr53w6ݵ׺18ؘx[Q85q Jnje rn:]ubJΪIp8^6!{sޞ䧻V*vk 71-\n#NZ)[yuO/puչw6\Q)qï *&]^>s57'}zq+zq+`<4J!<4J!| .'wa 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<SkN^jZFLܔ=?-f)VQͮ:/k^qte"Ys}y[(x.eDPViKU s 4o%̳N 1UYD̲ij/LN4DË!J Hk#=+W(ԲU"M4s|TB0Ĉ&,/ ;PAAAAAAAAAAӮxNE<JٕDܽ2Yp6\9~9"ַ[3Kֲ@UxW8qvqT3ˡ BF(<RlK.'O\48aˁ MDCKɲn%S @ (v8Æ:(6}([iK2[ Sb1PogZl˔(KXJĪ<97iHȦIJGf];XlݹBKe Nψ׎Qv $2lN $t]Oq6Rd"awx7mF>*ߢ*3+ځcLX^Avb)         ԮxNE<AۯS2 v](u (; ]Щ&59< R`TJJsp!]K+2*$LU 3Pmf'`xx"$[[XH2:s,`5Ch "b Oõ{OAAAAAAAAA@ծxNE<AG!c*8p#9AALX^Avb)         ֮7KijBkIA?q蘧   "bSgjN }SAAAAAAAAAnJ*kd/be-ޅY VhVRxp{ìMDzh7Nr#At߇l{ Ӧ;c܈n7Gt"=4Mvǹ:oö=ȏM~Dzh7Nr#At߇l{ Ӧ;c܈n7GiiJ`x{OU+YG&J!ZXޒIҥRؖu+K=L{         c9Ojeey pDևr%} ;+15܉_q=aJA hw"WbXkCzZȕDևr%} ;+15܉_q=aJGc)JHevJ[GH;          endstream endobj 1222 0 obj <>stream endstream endobj 1221 0 obj <>stream endstream endobj 1164 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.286 Tw 10 0 0 10 70.8661 335.1339 Tm (\200\f\036 \023\026\006\017\036\027\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 3\2266)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \024\002\f\035\036\007\024\r\026\027\t. )Tj 0.233 Tw 0 -1.218 TD (\215\024)Tj /Span<>> BDC ( )Tj EMC 1.566 0 Td [(\007\026\027\027\t\n )0.5(\022\035\017\027\017\022\024-\017\027\f\021\030\031\n\036\027\021\026\035\ \034\027\024\020\024 )0.6(\024\002\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.194 Tw -1.566 -1.218 Td (\027\017\016, \030\036\006\017\007\017\r \026\002\024\035\036\r\026\027\ \017\016 \007\017\026\020\027\024\f\021\017\030\024\r\026\027 \031)Tj /Span<>> BDC ( )Tj EMC (12/60 )Tj 0.1 Tw T* (\(20,0%; 95% \212\230: 10,8\22632,3\) \023\026\006\017\036\027\021\024\r\ . \221\026\022\017\n \024\002\030\026)Tj 0 Tw (-)Tj 0.203 Tw T* [(\024\n, )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.7(\n\036\021\024\007\026 )0.5(\f\024\f\021\026\r\017\035\026 )0.5(48/60 )0.5(\(80%; )]TJ 0 Tw T* (95% \212\230 67,7; 89,2\) \f\035\031\004\026\036\r.)Tj 0.108 Tw T* [(\210\006\036\027\022\026 )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\024\020\024 )0.5(\f\024\f\021\024\016\027\017\016 )0.6(\026\023\017\030\026\021\036\035\034\027\024\020\024 )]TJ 0.18 Tw T* [(\026\023\023\026\030\026\021\026 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.599 0 Td [(\023\024\n\024\013\017 )0.5(\f\235\017\027\022\021\036\030\024\n\036)]TJ 0 Tw (-)Tj 0.137 Tw -12.599 -1.218 Td (\021\030\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\t W)22(e)-18(xner, \r\t\023\024\035\027\036\027\027\024\036 \031)]TJ /Span<>> BDC ( )Tj EMC (46 \023\026\006\017\036\027\021\024\r )Tj 0.059 Tw T* [(\023\024\f\035\036 \024\023\036\030\026\006\017\017, \023\024\022\026\026\ \035\026 )0.5(\024\021\f\031\021\f\021\r\017\036 \023\024\r\030\036\032\007\026\033\013\ \036)]TJ 0 Tw (-)Tj 0.187 Tw T* (\020\024 \r\024\007\036\005\f\021\r\017\016 \n\036\021\024\007\026 \214\ \215\214 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\t\005 \f\235\017\027\022\021\036\030 )Tj 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.067 Tw T* (\212\035\016 \024\006\036\027\022\017 \r\024\n\024\032\027\t\b \023\030\ \036\007\017\022\021\024\030\024\r \030\026\r\017\021\017\016 \030\036\006\ \017)Tj 0 Tw (-)Tj 0.132 Tw T* (\007\017\r\026 \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017\ \023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \023\036\030\036\ )Tj 0 Tw (-)Tj 0.27 Tw T* (\n\036\013\036\027\027\024\020\024 \035\026\021\036\030\026\035\034\027\024\ \020\024 \035\024\f\022\031\021\026 \r\t\023\024\035\027\036\027 \031\027\ \017\r\026)Tj 0 Tw (-)Tj 0.41 Tw T* (\030\017\026\027\021\027\t\005 \026\027\026\035\017 \023\024\021\036\027\ \006\017\026\035\034\027\t\b \235\026\022\021\024\030\024\r \030\017\f\022\ \026 )Tj 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 0.002 Tc 0.098 Tw T* [(\210\007\027\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.275 0 Td [(\r\t\016\r\035\036\027\027\t\b )0.5(\235\026\022\021\024\030\024\r, )0.5(\023\024\r\t\001\026\033\013\017\n )0.5(\030\017\f\022)2( )]TJ 0.399 Tw -4.275 -1.218 Td (\030\026\r\017\021\017\016 \030\036\006\017\007\017\r\026 \f\r\017\013\026\ \023\030\016\n\024\005 \022\017\001\022\017, \016\r\035\016\035)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.248 Tw T* (\f\016 \031\r\036\035\017\004\036\027\027\t\005 \017\027\007\036\022\f \n\ \026\f\f\t \021\036\035\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\030\024\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.002 Tw T* (\027\017\017 )Tj /T1_1 1 Tf -0.017 Tc 0.017 Tw 2.014 0 Td [(RO)-19(C)]TJ /T1_0 1 Tf 0.002 Tc 0.226 Tw 1.475 0 Td (-\022\030\017\r\024\005 \r\t\016\r\035\036\027\024, \004\021\024 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\007\036\022\f\036 \n\026\f\f\t)2( )]TJ 0.202 Tw -3.489 -1.218 Td (\021\036\035\026)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC [(30,7 \022\020/\n\262 \r\024\030\026\f\021\026\036\021 \r\036\030\024\016\ \021\027\024\f\021\034 \r\024\r\030\026\021\026)2( )]TJ 0.016 Tw 23.244 25.574 Td (\026\002\024\035\036\r\026\027\017\016 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,14; 95% \212\230 1,02; 1,29; )Tj /T1_1 1 Tf 0 Tc 0 Tw (\032)Tj /T1_0 1 Tf 0.002 Tc 0.016 Tw /Span<>> BDC 19.044 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,02\))2( )]TJ 0 Tw -19.044 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0 Tc -0.003 Tw T* (\025\030\024\n\036 \021\024\020\024, \f\021\026\021\017\f\021\017\004\036\ \f\022\017 \027\026\004\017\n\t\n\017 \235\026\022\021\024\030\026\n\017\ \030\017)Tj 0 Tw (-)Tj -0.062 Tw T* (\f\022\026 \030\026\r\017\021\017\016 \030\036\006\017\007\017\r\026 \f\ \r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017 \016\r\035\016\ \035\017\f\034 )Tj 0.074 Tw T* (\020\027\024\005\027\t\036 \026\021\036\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5,50 \(95% )Tj 0.141 Tw T* (\212\230 1,14; 26,6\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.141 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\), \017\001\017\024\026\027\026\035\034\027\024\n \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (16,8 )Tj 0.142 Tw T* (\(95% \212\230 3,20; 7,55\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.142 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0009)Tj /T1_1 1 Tf 0 Tw (\))Tj /T1_0 1 Tf 0.142 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\035\034\r\017\024\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.145 Tw T* [(\027\024\n )0.5(\023\030\024\f\021\030\026\027\f\021\r\026\b )0.5(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 10.451 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(7,86 )0.5(\(95% )0.5(\212\230 )0.5(1,69; 36,6\), )]TJ /T1_1 1 Tf 0 Tw -10.451 -1.218 Td (\032)Tj /T1_0 1 Tf 0.134 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\b \022\024\n\002\017\027\026\006\017\016 \(\n\027\ \024\032\036\f\021\r\036\027\027\t\036 )Tj -0.003 Tw T* (\026\021\036\022\017\) \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4,40 \(95% \212\230 1,14; 16,9\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.003 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 )Tj -0.031 Tw T* [(\032\036 \r\030\036\n\016 \020\027\024\005\027\024-\r\024\f\023\026\035\017\ \021\036\035\034\027\t\036 )0.5(\024\004\026\020\017, \030\026\f\023\024\035\026\020\026\033)]TJ 0 Tw (-)Tj 0.055 Tw T* (\013\017\036\f\016 \030\036\021\030\024\030\036\022\021\026\035\034\027\024\ , \023\024\007\f\035\017\017\f\021\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\f\021\036\027\024\004)Tj 0 Tw (-)Tj T* (\027\024, \027\036 \031\b\031\007\001\026\035\017 \023\030\024\020\027\024\  \023\030\017\n\036\027\036\027\017\016 \214\215\214.)Tj 0.335 Tw T* (\222\021\024\017\021 \023\024\007\004\036\030\022\027\031\021\034, \004\021\ \024 \031)Tj /Span<>> BDC ( )Tj EMC (39/60 \(65,0%\) \002\024\035\034\027\t\b, )Tj 0.301 Tw T* (\r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036, \017\n\036\035\017\f\034 )0.5(\020\027\024\005\027\024-\r\024\f)]TJ 0 Tw (-)Tj 0.091 Tw T* (\023\026\035\017\021\036\035\034\027\t\036 \024\004\026\020\017 \(\026\021\ \036\022\017\), \031)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\020\024 \030\016\007\026 \023\026\006\017\036\027\021\024\r\ )Tj 0.282 Tw T* (\r\t\007\024\030\024\r\035\036\027\017\016 \031\007\026\035\024\f\034 \007\ \024\002\017\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (28/39 \(71,8%\) )Tj 0.039 Tw T* (\027\026\002\035\033\007\036\027\017\016\b. \200)Tj /Span<>> BDC ( )Tj EMC (23/39 \(59,0%\) \f\035\031\004\026\016\b \026\021\036\022\017 \017\n\036\ \035\017 )Tj -0.005 Tw T* (\n\027\024\032\036\f\021\r\036\027\027\t\005 \b\026\030\026\022\021\036\030\ , \023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \023\030\036\ \007\035\024)Tj 0 Tw (-)Tj -0.025 Tw T* (\032\036\027\027\024\020\024 \n\036\021\024\007\026 \f\r\017\013 \031\007\ \026\035\024\f\034 \035\017\022\r\017\007\017\030\024\r\026\021\034 \031\ )Tj /Span<>> BDC ( )Tj EMC (15/23 )Tj 0.309 Tw T* (\(65,2%\) \023\026\006\017\036\027\021\024\r. \221\026\022\017\n \024\002\ \030\026\024\n, \007\026\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.436 Tw T* (\035\017\004\017\017 \026\021\036\022\024\r, \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\026\004\017\n\024 \r\035\017\016\033\013\017\b \ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw 9 0 0 9 70.8661 730.483 Tm [(\020\004\206\f\t\204\004 )0.6(7.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\217\006\027\025\n\020 )0.5(\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 )0.7(\024\031\024\023\031\t\025\022\t )0.6(\016\020\033\022\032\020\023\027\f\017\025\031\b\031 )0.6(\020\033\033\020\032\020\023\020 )0.6(\033\032\t\026\031\235 )0.5(\n\022\213\n\022 )0.5(\030\031)]TJ /Span<>> BDC ( )Tj EMC 39.6 0 Td (\022)Tj /Span<>> BDC ( )Tj EMC 0.807 0 Td [(\033\031\024\f\027 )0.6(\033\032\022\026\027\025\027\025\022\t )0.5(\033\027\032\027)]TJ 0 Tw (-)Tj -40.408 -1.2 Td (\026\027\212\027\025\025\031\b\031 \f\020\023\027\032\020\f\017\025\031\b\ \031 \033\032\t\026\031\n\022\213\027\007\025\031\b\031 \f\031\024\n\r\023\ \020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.076 Tc 0.076 Tw 0 -1.2 TD [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.25 0 Td [( A)-17.8(s)-10.5(s)0.5(e)-22(s)-10.5(s)5.1(m)-5.2(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5(na)-4.5(l s)4.4(p)-1.1(h)1.7(i)3.9(n)-2.9(c)-32.4(t)-1.6(e)-6(r f)-18(u)0.6(n)-2.9(c)-32.4(t)-29.1(i)-1.4(o)-4(n b)-10.1(ef)-13.4(o)-3(r)-2(e a)-5.1(n)-4.8(d af)-50.9(t)-1.6(e)-6(r l)-1.1(a)-9.2(t)-1.6(e)-5.9(r)3.3(a)-4.5(l r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l \247)-66.8(a)-5.2(p r)-2(e)-7.7(p)-6.3(a)-6.3(i)4.9(r)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 704.381 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 704.381 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 490.6437 704.381 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 683.3118 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 683.3118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 683.3118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 490.6437 683.3118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 662.2505 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 662.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 662.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 490.6437 662.2505 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 641.1892 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 641.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 641.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 490.6437 641.1892 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 620.1279 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 365.9193 620.1279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 620.1279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 490.6437 620.1279 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 198.346 690.9464 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 22.063 0.6 Td (\031\002 \002\212\r\006\004\204\t\t)Tj 1.393 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj 5.648 1.2 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t)Tj 2.147 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_3 1 Tf 7.152 0.6 Td (\t)Tj /T1_0 1 Tf -53.953 -2.033 Td (\210\006\036\027\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 Wexner, \002\026\035\035\t, )Tj /T1_1 1 Tf (\215\027 \(Q1; Q3\))Tj T* (Min\231Max)Tj /T1_0 1 Tf 38.885 1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(0; 3\))Tj 0.48 -1.2 Td (0\22611)Tj 7.315 1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(0; 3\))Tj 0.48 -1.2 Td (0\22612)Tj 6.209 1.2 Td (0,68)Tj -53.37 -2.633 Td (\222\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021, )Tj /T1_1 1 Tf (\215\027 \(Q1; Q3\))Tj T* (Min\231Max)Tj /T1_0 1 Tf 38.135 1.2 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(37; 40\))Tj 0.98 -1.2 Td (29\22650)Tj 6.815 1.2 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(36; 40\))Tj 0.98 -1.2 Td (27\22646)Tj 6.459 1.2 Td (0,86)Tj 7.52 0 0 8 73.9508 632.5626 Tm (\204\026\022\f\017\n\026\035\034\027\024\036 \007\026\r\035\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n \f\024\022\030\026\013\036\027\017\017, \n\n \030\ \021.)Tj /Span<>> BDC ( )Tj EMC (\f\021., )Tj /T1_1 1 Tf (\215\027 \(Q1; Q3\))Tj 8 0 0 8 73.9508 622.9626 Tm (Min\231Max)Tj /T1_0 1 Tf 37.043 1.2 Td (148,5)Tj /Span<>> BDC ( )Tj EMC (\(127; 169\))Tj 1.823 -1.2 Td (93\226236)Tj 5.972 1.2 Td (150,5)Tj /Span<>> BDC ( )Tj EMC (\(130; 164\))Tj 1.823 -1.2 Td (98\226224)Tj 6.709 1.2 Td (0,46)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 603.4086 Tm (\020\004\206\f\t\204\004 8.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \210\025\022\021\020\032\022\020\025\023\025\013\235 \020\025\020\f\022\ \016 \203\020\n\023\031\032\031\021, \033\032\027\030\033\031\f\031\255\022\ \023\027\f\017\025\031 \021\f)0.5(\022\t\005\212\022\200 \025\020)]TJ /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\027 \032\027\006\022\030\022\021\020 \205\004\ \202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 8)-39.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.339 0 Td [( U)7.5(n)1.7(i)-2.9(v)6.3(a)-4.2(r)-38.9(i)1.5(a)-9.2(t)-1.6(e a)-5.1(na)-4.5(l)6.7(y)-5.3(s)-12.5(i)6.6(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(f)-8.1(a)-9.1(c)-32.4(t)-3(o)-3(r)-14.9(s p)-9.1(o)-2.9(t)-1.6(e)-7(nt)-29.1(i)1.5(a)-4.5(l)-3.9(l)6.6(y i)3.9(n)9.3(\247)-65.7(u)-3.2(e)-6.9(n)-3(c)2.9(e)-12.9(d A)10(F r)-2(e)-10.9(c)-0.6(u)1.7(r)-19.5(r)-2(e)-7(n)-2.9(c)2.8(e)]TJ ET /GS2 gs q 1 0 0 1 70.8661 588.1067 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 195.8405 588.1067 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 588.1067 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 588.1067 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 576.6375 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 195.8405 576.6375 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 576.6375 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 576.6375 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 565.1683 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 565.1683 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 565.1683 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 565.1683 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 553.707 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 553.707 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 553.707 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 553.707 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 542.2457 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 542.2457 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 542.2457 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 542.2457 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 530.7844 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 530.7844 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 530.7844 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 530.7844 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 519.3231 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 519.3231 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 519.3231 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 519.3231 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 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q 1 0 0 1 467.9665 462.0167 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 450.8054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 450.8054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 450.5554 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 439.0862 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 195.8405 450.5554 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 195.8405 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 450.5554 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 450.5554 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 427.6249 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 195.5905 439.0862 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 427.8749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 439.0862 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 427.8749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 439.0862 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 427.8749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 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393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 404.6944 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 404.6944 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 381.756 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 195.5905 393.2252 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 393.2252 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 393.2252 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 370.2947 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 195.5905 381.756 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 381.756 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 381.756 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 359.0834 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 370.2947 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 370.2947 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 370.2947 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 358.8334 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 195.8405 358.8334 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 358.8334 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 467.9665 358.8334 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 211.4378 579.4721 Tm (\203\004\220\003\002\006\013)Tj 23.752 0 Td (\017\016 \(95% \031\034\))Tj /T1_3 1 Tf 11.598 0.001 Td (\t)Tj /T1_0 1 Tf -52.536 -1.433 Td (\230\204\221, \022\020/\n)Tj 4.664 0 0 4.664 106.0864 570.6749 Tm 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2,76\))Tj 11.302 0 Td (0,69)Tj -51.953 -1.433 Td (\210\021\027\024\001\036\027\017\036 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 )Tj T* (\022)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\006\026\n \027\026\030\031\032\027\024\020\024 \f\235\017\027\022\ \021\036\030\026)Tj 22.949 1.2 Td (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 )Tj 17.702 0 Td (0,53)Tj /Span<>> BDC ( )Tj EMC (\(0,06; 4,80\))Tj 11.302 0 Td (0,57)Tj -29.175 -1.433 Td (\233\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 17.873 0 Td (6,60)Tj /Span<>> BDC ( )Tj EMC (\(0,79; 55,5\))Tj 11.302 0 Td (0,08)Tj -51.953 -1.433 Td (\212\017\026\n\036\021\030 \200\222\210, \n\n)Tj 40.651 0 Td (0,96)Tj /Span<>> BDC ( )Tj EMC (\(0,59; 1,57\))Tj 11.302 0 Td (0,88)Tj -51.953 -1.433 Td (\203\026\035\017\004\017\036 \020\027\024\005\027\024-\r\024\f\023\026\035\ \017\021\036\035\034\027\t\b )Tj T* (\024\004\026\020\024\r \(\026\021\036\022\024\r\))Tj 21.019 1.2 Td (\204\027\024\032\036\f\021\r\036\027\027\t\036 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\026\021\036\022)Tj 18.627 0 Td (5,50)Tj /Span<>> BDC ( )Tj EMC (\(1,14; 26,6\))Tj /T1_2 1 Tf 11.162 -0.001 Td (0,03)Tj /T1_0 1 Tf -29.061 -1.433 Td (\215\024\007\f\035\017\017\f\021\t\005 \026\021\036\022)Tj 17.898 0 Td (4,27)Tj /Span<>> BDC ( )Tj EMC (\(0,25; 73,8\))Tj 11.302 0 Td (0,31)Tj -29.895 -1.433 Td (\200\027\031\021\030\017\f\021\036\027\024\004\027\t\005 \026\021\036\022\ )Tj 18.686 0 Td (9,40)Tj /Span<>> BDC ( )Tj EMC (\(0,77; 144\))Tj 11.209 0 Td (0,07)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1774 56.0378 Tm (76)Tj ET endstream endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj <> endobj 27 0 obj <> endobj 28 0 obj <> endobj 1243 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1244 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1245 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1246 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1247 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1254 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.427 Tw 10 0 0 10 42.5197 615.2279 Tm (\r\n\036\001\026\021\036\035\034\f\021\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021 \f\024\f\021\024\016\021\036\035\034\027\024\f\ \021\017 \001\r\024\r )Tj 0.215 Tw 0 -1.218 TD [(\235\017\022\f\017\030\024\r\026\027\027\024\020\024 )0.5(\035\024\f\022\031\021\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj 0.173 Tw T* [(\035\024\032\027\036\027\017\005. )0.5(\215\026\035\034\006\036\r\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036 \023\030\016\n\024\005 )0.5(\022\017\001\022\017, )]TJ 0.064 Tw 0 -1.218 TD (\027\036 \023\030\024\r\024\007\017\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \n\036\f\016\006\026 \023\024\f\035\036 \024\ \023\036\030\026\006\017\017, )Tj 0.148 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \f\027\017\032\036\027\017\016 \030\017\f\022\026 \024\ \002\030\026\021\027\024\020\024 \f\n\036\013\036\027\017\016 \235\017\022\ )Tj 0 Tw (-)Tj 0.174 Tw 0 -1.218 TD (\f\017\030\024\r\026\027\027\024\020\024 \035\024\f\022\031\021\026. \212\ \035\016 \024\006\036\027\022\017 \030\036\031\035\034\021\026\021\024\r\ \023\030\017)Tj 0 Tw (-)Tj 0.198 Tw T* (\n\036\027\036\027\017\016 \n\036\021\024\007\026 \214\215\214, \002\t\035\ \017 \024\002\024\027\026\004\036\027\t \023\036\030\r\017\004\027\t\036\ )Tj 0.215 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\036 \022\024\027\036\004\027\t\036 \021\024\ \004\022\017, \023\036\030\r\017\004\027\024\005 \022\024\027\036\004\027\ \024\005 )Tj -0.034 Tw T* (\021\024\004\022\024\005 \016\r\035\016\036\021\f\016 \004\026\f\021\024\ \021\026 \027\036 \027\026\f\021\031\023\035\036\027\017\016 \030\036\006\ \017\007\017\r\026 \026)Tj 0 Tw (-)Tj 0.021 Tw T* (\002\024\035\036\r\026\027\017\016 \(\220\235\235\036\022\021\017\r\027\024\ \f\021\034 \035\036\004\036\027\017\016\), \r\021\024\030\017\004\027\t\n\ \017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.126 Tw T* (\024\006\036\027\022\026 \235\031\027\022\006\017\024\027\026\035\034\027\ \024\020\024 \f\024\f\021\024\016\027\017\016 \026\023\017\030\026\021\036\ \035\034\027\024\020\024 )Tj 0.403 Tw T* [(\026\023\023\026\030\026\021\026 \023\030\016\n\024\005 )0.5(\022\017\001\022\017; \r\t\030\026\032\036\027\027\024\f\021\017 \002\024\ \035\036\r\024\020\024 )]TJ 0.044 Tw T* (\f\017\027\007\030\024\n\026; \235\026\022\021\024\030\024\r \030\017\f\022\ \026, \023\030\036\007\023\024\035\024\032\017\021\036\035\034\027\024 \r\ \035\017\016)Tj 0 Tw (-)Tj T* (\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \030\036\006\017\007\017\r\026.)Tj /T1_2 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf -0.004 Tc 1.14 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 \024\002\030\026\002\ \024\021\022\026 \007\026\027\027\t\b \r\t\023\024\035\027\036\027\026)-4( )]TJ 0.154 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(RS)15(tudio \(R v. 4.4.1 \(R Cor)-24(e T)40(eam, V)-15(ienna, A)10(ustr)-37(ia\)\))-4( )]TJ 0.179 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\036\n \002\017\002\035\017\024\021\036\ \022 base, g)17(tsummar)-24(y, ggpl)30(o)17.1(t2,)-4( )]TJ 0.08 Tw T* (pROC, ROCR \017)Tj /Span<>> BDC ( )Tj EMC [(GenBinomApps. \003\027\026\004\036\027\017\016 \022\026\004\036\f\021\r\036\ \027\027\t\b)-4( )]TJ 0.403 Tw T* (\027\024\n\017\027\026\035\034\027\t\b \023\030\017\027\026\022\024\r \023\ \030\017\r\024\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\002\f\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.095 Tw T* (\035\033\021\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017\021\036\035\034\027\t\b \004\026\f\021\024\021 \(\ )Tj /T1_3 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf -0.004 Tc 0.095 Tw 14.483 0 Td ( \(%\) \017\035\017 )Tj /T1_3 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf -0.004 Tc 0.004 Tw 4.455 0 Td [(/N\(%\)\).)-4( )]TJ 0.279 Tw -18.937 -1.218 Td (\203\036\023\030\036\030\t\r\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\036 \023\024\030\016\007\022\024\r\ \t\036 \r\036\035\017\004\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.185 Tw T* (\027\t \(\023\030\017 \004\017\f\035\036 \027\026\004\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC [(5\) \024\023\017\f\t\r\026\035\017 \n\036\007\017\026\027\024\005,)-3.9( )]TJ 0.121 Tw T* (\027\017\032\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\n \022\r\026\030\021\017\035\016\n\017 \(Me \(Q1; Q\ 3\)\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.191 Tw T* (\032\036 \030\026\n\026\b\024\n \(Min\226Max\). \222)Tj /Span<>> BDC ( )Tj EMC [(\006\036\035\034\033 \024\006\036\027\022\017 )0.5(\007\017\027\026\n\017\022\017)-4( )]TJ 0.247 Tw T* [(\017\n\036\027\036\027\017\016 \022\024\035\017\004\036\f\021\r\036\027\ \027\t\b \023\024\022\026\026\021\036\035\036\005 \023\030\017\n\036\027\ \016\035\017)-4( )]TJ 0.302 Tw T* [(\022\030\017\021\036\030\017\005 \211\017\035\022\024\022\f\024\027\026 \ \007\035\016 \f\r\016\026\027\027\t\b \020\030\031\023\023. \215\024\017\ \f\022)-4( )]TJ 0.324 Tw T* [(\235\026\022\021\024\030\024\r, \022\024\021\024\030\t\036 \n\024\020\035\ \017 \002\t \002\t\021\034 \026\f\f\024\006\017\017\030\024\r\026\027\t)-4( )]TJ 0.207 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\024\027\017\022\027\024\r\036\027\017\036\n \030\036\006\017\007\017\ \r\026, \024\f\031\013\036\f\021\r\035\016\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.22 Tw T* (\013\034\033 \031\027\017\r\026\030\017\026\027\021\027\024\020\024 \035\ \024\020\017\f\021\017\004\036\f\022\024\020\024 \030\036\020\030\036\f\f\ \017\024\027\027\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.087 Tw T* (\020\024 \026\027\026\035\017\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\022\026\026\027\017\036\n \027\026\004\036\027\017\016 \024\021\027\ \024\001\036\027\017\016 \001\026\027\f\024\r)-4( )]TJ -0.033 Tw T* (\(\210\231\) \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 95% \212\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \200\026\035\034\007\026. \212\035\016 \024\006\036\ \027\022\017 \r\035\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.034 Tw T* (\016\027\017\016 \022\024\035\017\004\036\f\021\r\036\027\027\024\005 \023\ \036\030\036\n\036\027\027\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\017\f\b\024\007 \023\030\024\r\036\007\036\027)-3.9( )]TJ /T1_3 1 Tf -0.023 Tc 0.023 Tw 0 -1.218 TD [(RO)-19(C)]TJ /T1_1 1 Tf -0.004 Tc 0.226 Tw 1.457 0 Td (-\026\027\026\035\017, \030\026\f\f\004\017\021\t\r\026\035\017 \023\035\ \024\013\026\007\034 \023\024\007 )Tj /T1_3 1 Tf -0.023 Tc 0.023 Tw [(RO)-19(C)]TJ /T1_1 1 Tf -0.004 Tc 0.004 Tw 17.352 0 Td [(-\022\030\017\r\024\005)-4( )]TJ 0.042 Tw -18.809 -1.218 Td [(\(A)17(UC\), \036\036 \f\021\026\027\007\026\030\021\027\024\036 \024\021\022\035\ \024\027\036\027\017\036, 95% \212\230 \017)]TJ /Span<>> BDC ( )Tj EMC [(\031\030\024\r\036\027\034)-4( )]TJ 0.369 Tw 0 -1.218 TD (\027\026\004\017\n\024\f\021\017. \210\021\030\036\027\031\033 \021\024\ \004\022\031 \024\023\030\036\007\036\035\016\035\017 \022\030\017\021\036\ \030\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.135 Tw T* [(\036\n \247\024\007\036\027\026; \007\035\016 \027\036\036 \030\026\f\f\004\ \017\021\t\r\026\035\017 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\ \021\034,)-4( )]TJ 0.065 Tw T* (\f\023\036\006\017\235\017\004\027\024\f\021\034, \023\030\036\007\f\022\ \026\026\021\036\035\034\027\031\033 \006\036\027\027\024\f\021\034 \023\ \024\035\024\032\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.006 Tw T* (\021\036\035\034\027\024\020\024 \030\036\031\035\034\021\026\021\026 \(\ \215\037\215\217\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\022\026\026\021\036\035\034\027\031\033 \006\036\027\ )Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.036 Tw T* (\027\024\f\021\034 \024\021\030\017\006\026\021\036\035\034\027\024\020\024\ \030\036\031\035\034\021\026\021\026 \(\215\037\210\217\); \007\035\016\ \220\021\017\b \023\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.047 Tw T* (\022\026\026\021\036\035\036\005, \026)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \007\035\016 \023\036\030\r\017\004\027\024\005 \021\ \024\004\022\017 \017\f\f\035\036\007\024\r\026\027\017\016)-4( )]TJ 0 Tw T* (\030\026\f\f\004\017\021\t\r\026\035\017 95% \212\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \025\035\024\023\023\036\030\026\226\215\017\030\f\ \024\027\026.)Tj 0 Tc 1.255 Tw T* (\217\026\035\017\004\017\016 \f\004\017\021\026\035\017 \f\021\026\021\017\ \f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\017 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 615.2279 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.001 Tw 10 0 0 10 274.9606 590.8719 Tm (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017 \f\024\f\021\026\r\035\016\035\026 \024\021 15 \007\024)Tj /Span<>> BDC ( )Tj EMC (95 \n\017\027\031\021 )Tj -0.012 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\036 \r)Tj /Span<>> BDC ( )Tj EMC (40 \(30; 50\) \n\017\027\031\021, \017\027\021\030\026\024\023\036\030\026\ \006\017\024\027\027\t\b )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \027\036 \026\235\017\022\f\017\030\ \024\r\026\027\024.)Tj 0.044 Tw T* (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \023\026\006\017\036\027\021\024\r \024\002\036\ \002\024\035\017)Tj 0 Tw (-)Tj 0.122 Tw T* (\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \023\030\036\023\026\030\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \027\036\f\021\036\030\024\017\007)Tj 0 Tw (-)Tj 0.205 Tw T* (\027\t\b \023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\ \027\t\b \f\030\036\007\f\021\r, \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036\027\017\017 )Tj 0.271 Tw T* (\027\026\030\022\024\021\017\004\036\f\022\017\b \026\027\026\035\034\020\ \036\021\017\022\024\r \027\036 \002\t\035\024 \027\036\024\002\b\024\007\ \017\n\024)Tj 0 Tw (-)Tj 0.152 Tw T* (\f\021\017. \204\036\007\017\026\027\026 \031\030\024\r\027\016 \002\024\ \035\036\r\024\020\024 \f\017\027\007\030\024\n\026 \027\036 \023\030\036\ \r\t)Tj 0 Tw (-)Tj 0.216 Tw T* (\001\026\035\026 3)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r \026)Tj /Span<>> BDC ( )Tj EMC (\r\036\f\034 \023\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\ \016 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b )Tj 0.326 Tw T* [(\023\026\006\017\036\027\021\024\r. )0.6(\204\026\022\f\017\n\026\035\034\027\026\016 )0.6(\017\027\021\036\027\f\017\r\027\024\f\021\034 )0.6(\002\024\035\036\r\024\020\024 )]TJ 0 Tw T* (\f\017\027\007\030\024\n\026 \027\026\002\035\033\007\026\035\026\f\034 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2264)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017, \ )Tj 0.072 Tw T* (\004\021\024, \027\026\017\002\024\035\036\036 \r\036\030\024\016\021\027\ \024, \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\n \026\022\021\024\n \007\036)Tj 0 Tw (-)Tj 0.06 Tw T* (\235\036\022\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036. \215\024\f\035\036 4-\t\b )Tj 0.165 Tw T* (\f\031\021\024\022 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \017\ \027\021\036\027\f\017\r\027\024\f\021\034 \002\024\035\036\r\t\b \024\013\ \031)Tj 0 Tw (-)Tj 0.175 Tw T* (\013\036\027\017\005 \027\026\004\017\027\026\036\021 \026\022\021\017\r\ \027\024 \f\027\017\032\026\021\034\f\016, \026)Tj /Span<>> BDC ( )Tj EMC (\022 10-\n\031 \007\027\033 )Tj 0 Tw T* (\002\024\035\034 \023\030\026\022\021\017\004\036\f\022\017 \024\021\f\031\ \021\f\021\r\031\036\021 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.086 Tw T* (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (14-\036 \f\031\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (1/60 )Tj 0.136 Tw T* [(\(1,7%\) \027\026\002\035\033\007\036\027\017\017 )0.5(\026\235\017\022\f\017\030\024\r\026\027\026 \030\036\021\030\026\022\006\ \017\016 \035\026\021\036)]TJ 0 Tw (-)Tj 0.205 Tw T* (\030\026\035\034\027\024\020\024 \035\024\f\022\031\021\026, \023\026\006\ \017\036\027\021\031 \r\t\023\024\035\027\036\027\024 \023\030\024\r\036\ \007\036\027\017\036 )Tj 0 Tw T* (\035\017\020\026\021\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\026\n\002\031\035\026\021\024\030\027\t\b \031\f\035\024\r\017\016\b.)Tj 0.096 Tw T* (\204\036\007\017\026\027\026 \022\024\035\017\004\036\f\021\r\026 \007\027\ \036\005, \023\030\024\r\036\007\036\027\027\t\b \023\026\006\017\036\027\ \021\026\n\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036, \f\024\f\021\026\r\017\035\026 7\ \(6,0;8,5\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \004\031\n\020\016\020\023\027\f\022 \024\203\022\025\n\023\027\032\031\ \026\027\023\032\022\022 \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021, \021\n\f\005\007\027\025\025\013\200\ \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027, \030\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\027\032\020\023\022\021\025\031\b\031 \021\026\027\213\020\023\027\ \f\017\024\023\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.002 Tc -0.002 Tw 3.329 0 Td [( S)11.1(p)0.9(h)3.7(i)5.9(n)-0.9(c)-30.4(te)-3.9(ro)-2(m)-3.3(e)-6.6(t)-7.6(r)-41.8(y)2( p)-4.3(a)-2.2(r)5.4(a)-3.1(m)-3.3(e)-6.6(te)-4(r)-12.9(s)2( b)-8.1(e)1.9(f)-11.3(o)-1(re)2( s)8.7(u)3.6(rg)-4.8(e)-4(r)-41.8(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 42.7697 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 371.5886 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 715.181 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 309.2264 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 371.3386 703.7117 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 371.5886 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 703.7117 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 692.2426 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 42.7697 680.7812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 692.2426 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 692.2426 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 692.2426 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 692.2426 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 680.7812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 680.7812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 669.5699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 680.7812 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 246.8642 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 680.7812 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 309.2264 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.5699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 669.5699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 669.3199 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 42.7697 657.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 669.3199 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 669.3199 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 669.3199 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.3199 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 657.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 657.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 646.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 657.8587 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 246.8642 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 657.8587 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 309.2264 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 646.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 646.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 646.3974 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 246.8642 646.3974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 646.3974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 646.3974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 433.9508 646.3974 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_5 1 Tf 0 Tc 0 Tw 8 0 0 8 104.3951 700.8117 Tm (\200\002\220\004\213\004\003\r\f\t \240\004\f\r\b\t\235 )Tj /Span<>> BDC ( )Tj EMC (\004\b\004\f\001\b\002\214 \220\004\b\004\f\r)Tj 28.106 0.6 Td (\025\002\006\214\004)Tj -0.995 -1.2 Td (\(min\232max\))Tj 7.991 1.317 Td (\034\217\217\f\r\240\210\r\214\004\235 \n\006\210\212\212\004, N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj -0.38 -1.434 Td (\215\r \(Q1; Q3\))Tj 8.498 0 Td (Min\232Max)Tj /T1_1 1 Tf -50.568 -1.433 Td (\222\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \n\n \030\021.\f\021.)Tj 26.998 0 Td (\240\036\027\013\017\027\t)Tj 8.574 0 Td (41\22663)Tj 6.815 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(37; 40\))Tj 8.776 0 Td (29\22650)Tj -24.05 -1.433 Td (\204\031\032\004\017\027\t)Tj 8.46 0 Td (43\22661)Tj -35.572 -1.433 Td (\204\026\022\f\017\n\026\035\034\027\024\036 \007\026\r\035\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n )Tj T* (\f\024\022\030\026\013\036\027\017\017, \n\n \030\021.\f\021.)Tj 26.998 1.2 Td (\240\036\027\013\017\027\t)Tj 8.074 0 Td (110\226178)Tj 6.222 0 Td (148,5)Tj /Span<>> BDC ( )Tj EMC (\(127; 169\))Tj 9.618 0 Td (93\226236)Tj -23.8 -1.433 Td (\204\031\032\004\017\027\t)Tj 7.96 0 Td (121\226227)Tj ET q /GS0 gs 221.1023475 0 0 192.5342954 274.9606228 122.6196675 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.008 Tw 9 0 0 9 274.9606 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\022\025\020\026\022\n\020 \r\032\031\021\025\t \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020 \033\031\024\f\027 \031\033\027)Tj 0 Tw (-)Tj T* (\032\020\006\022\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\211\003\237 \021)Tj /Span<>> BDC ( )Tj EMC (\023\027\007\027\025\022\027 10 \030\025\027\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0.034 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( P)18(ain scores \(according to the Visual Analogue Scale, )]TJ 0 Tw T* [(V)42(A)50(S\) for 10 d)26.1(ays in postoperativ)13.1(e per)-36.9(iod)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.8394 56.0378 Tm (75)Tj ET endstream endobj 1255 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   &_5Ert!"12AQTU #$%&'()*346789:BCDFGHIJRSVaWXYZbcdefghijqsuvwxyzk!A1a24Qq#3rѲ "$%&'()*56789:BCDEFGHIJRSTUVWXYZbcdefghijstuvwxyz? 9AjVy<0ⴉi0QE ))v?^aه,#.;0rd~?άvr7~?fLGß3ӳY&G#\va<X;0rd~?fLGՀӳX#.;0rd~?ζ=1;0rd~?fLGՀӳY&G#\va<ߑ:(C{0rd~?fLGՀӳY&G#\va<X;0o9gs[Öyɑr92?V;N9gqه,~G#\̡xÖyɑr92?V;N9gqه,#.u`Öyɑr92?Xw;>9gqه,#.u`Öyɑr92?V;N9g?Y&G#\biه,#.;0rd~?άvr92?YGՙx\va<9gsfLGÖyɑ:va<ߑr92?ZEbva<9gsfLGÖ?Y%va<9gs<Ġ,(i(V_6rI-~;+Ev;((w"7$jf=uX 2˽v>Ъv:ک;8CaqEv(*P&'\ MND%~7|j~Zj{g^s5v(k }S6IL_]( ҪP:єu#;}C꟯FQ:P|LQ왉{&bV9/YQs I_Bd/}}yؽ y(q@1|EﰳQg\H, /[Luod1p,p(6K| 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Htln)9H򟃘čU|{aItڂT{6xS$X9"ǘmeoA[%f=uX 2˽v>c$c&Z.۔|ժwdV9[,P q+V5ik܍J]lx2HluZSvR״\(Ԝ;]C꟯FQ6b*U~ CsrK.rIbY,2JrI$3GIy2l9gOtkK\S9UYf8bmD̞I-P(F(+Қ?9(+Қ?9ny k'gƟTGk_|P\< |LPjMQzLtaHd̲C,$dl(bQZy$3  In$7;81$)w4.r7rꘀQ˹w_IuGrꘀ ݼ_cܻ=1˹w_IuGrꘀ uT+6旤,^˺K;uTeܻw_IuL@jW`8]]P/}}y]˺K;uTeܻ,$YR#ܕw1yr}%1w..]]S&'Zլ;(9r9r{y8ukHN)Njrg[,}sܻw_IuL@]˺KeqC}ġ4βyy-VKQ-mlOMҴN% jRO1..?F!jsTɚMznnIfr̶bVgekj(g'$cL6pM<3fr'YG.G4Xƥ .PW)4"sPW)4"sЕ,Oύ>&I5P(5S׭}B1(+Қ?9U\)3NE?ɐI$2K&ƍ]_[# jaY3ll2k}dsZ6 +8"j8 P’R3"kBj8&(XsHA֙|nSK&9|t1x\6QanrI:=ÛLގ)No7%dqE9CVvn졅ĜT&yɖesn%h\9%1* =`),I-s[e=vkU!C[Y9}$Xʮ“8TWfޗ:t{%yYQEg QEgeE)C5)MeMuHKc\.tKI9ib),E,˘/TtqR4Ze^8vpNdPܫq9A0jrMM*'Hb,ŬIfIeE.JeYFVvN+ɩ3Ԧga{S|m]SvMi MYu&Plrjf.3sqI6 $ʹ#$Rl$$]8RJnJt[IIKp_#n+TuSY;VR.N,ۣ(m;'Z\w5Ǔ;[TBe ]Gϱ֪Q'*)+82G أp4)ruR⃲=JҏߤXw#Zɐ-mofŭ-x&L-U:u-2XPAn;JIb]W~#Pө%[kqDrm8u(!wdܧ$A;#ԯ=(GRV;N+J?~(;#ԯ=(GՒr (m;8-TqK[''(SsI7T3S2k{KRVm'Mp9iR↍U|;<04V* 4QbQILvG^zQAyG?vW~#Poc Qjյs&&\b.x4*m&TY4y=IoC6Q8]Iz)8W~#PvG^zQCdzHW~#PsdVT bQiuʥq5jRnQ"HեK[V1뉸{(U0Rs;#ԯ=(GRV;N+J?~(n3S-TXE -)C;NΈNSr*ȭ)(Օ8;;E5e (sjR⃲=JҏߤX;#ԯ=(GRV;k,R- jN88X)қzŜj~ZYŪm8ⅸrX[SO\x3Vdy>YFXibS$8~O.Uo`I''JN+J?~(;#ԯ=(GՀӲ=Jҏߤ+J?~(uf vx(=0(LA^n)Ɣ͒NQ,ѫ=Jҏߤf&ɲ2X"a5Rt ^vG^zQAyG?vW~#P7SOgN8+%pPpU5#'>(d'Yk7VڔQNER⃲=JҏߤX;#ԯ=(GRV;=LKkUA8bɢQ]W!;Nq{#ԯ=(G'&ԬR-r_7 !\7QC$t@dzHW~#PdY K[K2ٳfʼnlX`;N+J?~(nu7S2{;(5RV$K''iDtiڝaX7~8m`ʬ i(W' ;ңI$l=Jҏߤ+J?~(5c""';8-zݤWGfvEvyu`Kc9>QclF8m,)J)sLdu}9NY;EpΎq20תvv~'Rjp9DrfvMvYZ9Gf1)95 nQ[eV+KH8snTU5rM4ӣYnŗ-GGm*IDinT5i+5PFqBr jn[}[ZXYG,*OmSY=qZFPY($ejtpCmr8mlpZ P6Ӫk}9˲}O {);8lvNPCz'z3rIPYEN'Pc';+xaJŤ⢾:ͬkqr><יG;Qq#rQp[e6ڥOZ((jq;' Pi:NH%5&l [qCFxpz:Ş6%;X&B1)Ѯqi6&ۉv8"q(n(mVums NPMfheqZEqQMͶx@\)]Q7 ;oYfRwhN;n4 ൴QCqBpBM *5ܢ;hHNK24Ъ endstream endobj 1256 0 obj <>stream endstream endobj 1253 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.005 Tw 10 0 0 10 70.8661 128.1078 Tm [(\217\006\027\025\n\020 )0.5(\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 )0.5(\024\031\024\023\031\t\025\022\t )0.5(\016\020\033\022\032\020\023\027\f\017\025\031\b\031 )]TJ 0 Tw 0 -1.218 TD (\020\033\033\020\032\020\023\020 \033\032\t\026\031\235 \n\022\213\n\022\ )Tj /T1_1 1 Tf 0.105 Tw T* (\215\024 \007\026\027\027\t\n \f\235\017\027\022\021\036\030\024\n\036\021\ \030\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (49/60 \(81,7%\) \023\026\006\017)Tj 0 Tw (-)Tj 0.023 Tw T* [(\036\027\021\024\r, )0.5(\r\022\035\033\004\036\027\027\t\b )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.861 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\036, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.432 0 Td (\007\024\024\023\036\030\026\006\017\024\027)Tj 0 Tw (-)Tj 0.086 Tw -16.293 -1.218 Td (\027\024\n \220\021\026\023\036 \r\t\016\r\035\036\027\024 \f\027\017\032\ \036\027\017\036 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n )Tj 0.066 Tw 23.244 64.543 Td (\022\026\027\026\035\036, \f\024\024\021\r\036\021\f\021\r\031\033\013\036\ \036 1 \f\021\036\023\036\027\017 \027\036\007\024\f\021\026\021\024\004\ \027\024\f\021\017 )Tj 0.047 Tw T* (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026.\ \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007)Tj 0 Tw (-)Tj 0.2 Tw T* (\027\024\n \f\035\031\004\026\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \020\030\031\023\023\036 \023\026\006\017\036\027\021\024\ \r \027\036 \002\t\035\024 \022\035\017)Tj 0 Tw (-)Tj 0.489 Tw T* [(\027\017\004\036\f\022\017\b )0.5(\023\030\024\016\r\035\036\027\017\005 )0.6(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 )0.6(\026\027\026\035\034\027\024\020\024 )]TJ 0.003 Tw T* (\f\235\017\027\022\021\036\030\026. \200)Tj /Span<>> BDC ( )Tj EMC (3/60 \(5,0%\) \027\026\002\035\033\007\036\027\017\016\b \r\t\016\r\035\036\ \027\026 \027\036)Tj 0 Tw (-)Tj -0.005 Tw T* (\007\024\f\021\026\021\024\004\027\024\f\021\034 \026\027\026\035\034\027\ \024\020\024 \f\235\017\027\022\021\036\030\026 2 \f\021\036\023\036\027\ \017, \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017)Tj 0 Tw (-)Tj 0.154 Tw T* [(\027\017\004\036\f\022\017\n\017 )0.6(\023\030\024\016\r\035\036\027\017\016\n\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.085 0 Td [(\r\017\007\036 )0.5(\027\036\007\036\030\032\026\027\017\016 )0.6(\020\026\024\r )]TJ 0 Tw -12.085 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\032\017\007\022\024\020\024 \022\017\001\036\004\027\024\020\024 \f\024\ \007\036\030\032\017\n\024\020\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.06 Tw T* (\215\030\017 \024\006\036\027\022\036 \235\031\027\022\006\017\017 \007\036\ \030\032\026\027\017\016 \022\017\001\036\004\027\024\020\024 \f\024\007\ \036\030\032\017)Tj 0 Tw (-)Tj 0.244 Tw 0 -1.218 TD (\n\024\020\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \001\022\026\035\t \026\027\026\035\034\027\024\005\ \017\027\022\024\027\021\017\027\036\027\006\017\017 )Tj 0.162 Tw 0 -1.218 TD [(W)22(e)-18(xner \r)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\n \023\036\030\ \017\024\007\036 \002\026\035\035\t \r\026\030\034\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\024\r\026\035\017 \024\021 0 \007\024)Tj /Span<>> BDC ( )Tj EMC (11, \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\026 \f\024\f\021\026\r\017\035\026 1 \(0; 3\) \002\ \026\035\035.)Tj /T1_0 1 Tf 0.12 Tw 0 -2.436 TD (\027\200\025\022\n\020 \031\033\027\032\020\006\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\030\027\025\022\027 \033\020\006\022\027\025\023\031\021 \021)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\032\020\006\022\031\025\025\031\026 \033\027\032\022\031\030\027)Tj /T1_1 1 Tf 0.758 Tw 0 -1.218 TD (\216\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\024 \r\t\023\024\035\027\016\036\021\f\016 \023\024\007\ )Tj 0.211 Tw 0 -1.218 TD (\f\023\017\027\026\035\034\027\024)Tj /Span<>> BDC (\005)Tj EMC ( \026\027\036\f\021\036\017\036)Tj /Span<>> BDC (\005)Tj EMC ( \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\023\017\027\036 \022\026\022 )Tj 0.309 Tw 0 -1.218 TD (\007\035\016 \035\017\021\024\021\024\n\017\017. \215\024\f\035\036 \026\ \027\021\017\f\036\023\021\017\004\036\f\022\024\005 \024\002\030\026\002\ \024\021\022\017 )Tj 0.083 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\r\017\017\017 \023\036\030\017\026\027\026\035\034\027\024\005\ \024\002\035\026\f\021\017, \026\027\026\035\034\027\024\020\024 \022\026\ \027\026\035\026, )Tj 0.047 Tw 0 -1.218 TD (\024\027\007\017\030\024\r\026\027\017\016, \023\030\024\022\030\026\001\ \017\r\026\027\017\016 \022\030\026\f\017\021\036\035\036\n \f\r\017\013\ \036\r\024)Tj 0 Tw (-)Tj -0.033 Tw 0 -1.218 TD (\020\024 \b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\020\027\024\005\027\t\b \023\024\035\024\f\021\036\005 \r\t\023\024\035\ \027\016\036\021\f\016 \023\036\030\r\t\005 \220\021\026\023 )Tj 0.035 Tw T* (\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 \017\f\f\036\004\036\027\017\036 \f\r\017\013\036\r\024)Tj 0 Tw (-)Tj 0.01 Tw T* (\020\024 \b\024\007\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 \f\021\036\027\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\f\022\030\t\021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036)Tj 0 Tw (-)Tj 0.099 Tw T* [(\027\017\030\024\r\026\027\017\036 )0.6(\020\027\024\005\027\024-\r\024\f\023\026\035\017\021\036\035\034\027\t\b\ )0.6(\024\004\026\020\024\r )0.5(\(\026\021\036\022\024\r\) )]TJ 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \027\026\035\017\004\017\017.)Tj 0.122 Tw T* (\200\021\024\030\t\n \220\021\026\023\024\n \r\t\023\024\035\027\016\036\ \021\f\016 \023\035\026\f\021\017\004\036\f\022\024\036 \026\022\030\t\021\ \017\036 )Tj 0.237 Tw T* [(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\r\017\013\036\r\024\020\024 )0.5(\024\021\r\036\030\f\021\017\016 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.084 0 Td [(\023\024\n\024\013\017 )0.5(\035\026)]TJ 0 Tw (-)Tj 0.221 Tw -17.084 -1.218 Td (\021\036\030\026\035\034\027\024\020\024 \023\030\016\n\024\022\017\001\036\ \004\027\024\020\024 \035\024\f\022\031\021\026. \215\024\f\035\036 \020\ \017\007\030\024)Tj 0 Tw (-)Tj 0.335 Tw T* (\023\030\036\023\026\030\024\r\022\017 \023\024\007\f\035\017\017\f\021\ \024\020\024 \f\035\024\016 \f\021\036\027\022\017 \026\027\026\035\034\027\ \024\020\024 )Tj 0.103 Tw T* (\022\026\027\026\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\020\024 \024\021\007\036\035\026 \027\ \017\032\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021)Tj 0 Tw (-)Tj 0.101 Tw T* (\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\036\022\006\017\017 \r\027\031\021\030\036\027\027\036\020\024\ \f\r\017\013\036)Tj 0 Tw (-)Tj 0.143 Tw 0 -1.218 TD (\r\024\020\024 \024\021\r\036\030\f\021\017\016, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \n\024\002\017\035\017\026\006\017\017 \035\026\021\ \036\030\026\035\034\027\024\020\024 )Tj 0.276 Tw 0 -1.218 TD (\f\035\017\017\f\021\024-\023\024\007\f\035\017\017\f\021\024\020\024 \ \035\024\f\022\031\021\026 \024\f\021\030\t\n \023\031\021\036\n \r\t)Tj 0 Tw (-)Tj 0.358 Tw 0 -1.218 TD (\023\024\035\027\016\036\021\f\016 \007\031\020\024\024\002\030\026\027\ \t\005 \030\026\030\036 \026\027\024\007\036\030\n\t. \212\026\035\036\ \036 )Tj 0.349 Tw T* [(\021\030\026\027\f\026\027\026\035\034\027\t\n )0.5(\007\024\f\021\031\023\024\n, \024\021 \f\r\017\013\036\r\024\020\024 \024\ \021\r\036\030\f\021\017\016 )]TJ -0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\024\n \027\026\023\030\026\r\035\036\027\017\017, \n\024\ \002\017\035\017\031\036\021)Tj 0 Tw (-)Tj -0.016 Tw T* [(\f\016 \f\035\017\017\f\021\024-\023\024\007\f\035\017\017\f\021\t\005\ )0.5(\035\024\f\022\031\021 \f\021\036\027\022\017 \027\017\032\027\036\026\n\ \023\031)]TJ 0 Tw (-)Tj 0.035 Tw T* (\035\016\030\027\024\020\024 \024\021\007\036\035\026 \023\030\016\n\024\ \005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\r\036\030\027\024\027\024\005 \021\022\026\027\034\033 )Tj 0.054 Tw T* (\(\002\035\017\032\026\005\001\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \024\023\036\030\026\006\017\017 \r\027\031\021\030\036\027\ \027\017\005 \020\036\n\024\030\030\024\017)Tj 0 Tw (-)Tj 0.111 Tw T* (\007\026\035\034\027\t\005 \031\036\035\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \027\026\035\017\004\017\017. \215\030\024\017\r\024\007\017\021\ \f\016 \022\030\026\005)Tj 0 Tw (-)Tj 0.085 Tw T* (\027\036 \220\022\024\027\024\n\027\024\036 \017\f\f\036\004\036\027\017\ \036 \023\026\021\024\035\024\020\017\004\036\f\022\017 \017\n\036\027\036\ \027\027\t\b )Tj 0.012 Tw T* (\021\022\026\027\036\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 \253\f\022\036\035\036\021\017\017\030\024\r\ \026\027\027\024\020\024\273 )0.5(\r\027\031\021\030\036\027\027\036\020\024 )]TJ T* [(\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, )0.5(\035\017\002\024 )0.5(\036\020\024 \022\033\030\036\021\026\032, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033)Tj 0 Tw (-)Tj 0.091 Tw T* (\013\017\n \036\020\024 \031\001\017\r\026\027\017\036\n. \212\026\035\036\ \036 \f\235\024\030\n\017\030\024\r\026\027\027\t\005 \035\024\f\022\031\ \021 )Tj 0.043 Tw T* (\f\n\036\013\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \f\r\017\013\036\r\024\020\024 \024\021\r\036\ \030\f\021\017\016, \026\022\030\t\r\026\016 )Tj 0.066 Tw T* [(\036\020\024. )0.5(\003\026\021\036\n )0.5(\023\030\024\017\r\024\007\017\021\f\016 )0.6(\235\017\022\f\026\006\017\016 )0.6(\022\030\026\016 )0.5(\023\036\030\036\n\036\013\036\027)]TJ 0 Tw (-)Tj 0 -1.218 TD (\027\024\020\024 \035\024\f\022\031\021\026 \022)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\033 \f\235\024\030\n\017\030\024\r\026\027\027\024\005 \030\ \026\027\t.)Tj 0.298 Tw 0 -1.218 TD (\200 \023\036\030\r\t\036 \f\031\021\022\017 \023\024\f\035\036 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\ )Tj 0 Tw (-)Tj 0.257 Tw 0 -1.218 TD [(\f\021\r\026 )0.5(\023\024\f\021\036\035\034\027\t\005 )0.6(\030\036\032\017\n )0.5(\023\026\006\017\036\027\021\026\n )0.6(\027\036 )0.5(\027\026\027\026\004\026\035\f\016. )]TJ 0.284 Tw 0 -1.218 TD (\203\026\004\017\027\026\016 \f\024 \r\021\024\030\t\b \f\031\021\024\022\ , \023\026\006\017\036\027\021\t \023\036\030\036\r\024\007\017\035\017\f\ \034 )Tj 0.225 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\005 \002\024\035\034\027\017\004\027\t\005 \030\036\032\ \017\n, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\036\n \026)Tj 0 Tw (-)Tj 0.091 Tw 0 -1.218 TD (\027\016\021\017\016 \023\024\035\024\032\036\027\017\016 \f\017\007\016\ . \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017)Tj 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD (\024\007\036 \023\026\006\017\036\027\021\026\n \036\032\036\007\027\036\ \r\027\024 \r\t\023\024\035\027\016\035\017\f\034 \023\036\030\036\r\016\ \022\017, )Tj -0.013 Tw 0 -1.218 TD (\r\022\035\033\004\026\r\001\017\036 \024\006\036\027\022\031 \f\024\f\021\ \024\016\027\017\016 \024\002\035\026\f\021\017 \024\023\036\030\026\021\ \017\r\027\024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.145 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \202\f\022\025\022\007\027\024\n\020\t \200\020\032\020\n\023\027\032\022\ \024\023\022\n\020 \033\020\006\022\027\025\023\031\021, \021\031)Tj 0 Tw (-)Tj 0 -1.2 TD (\213\027\030\213\022\200 \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.463 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.436 Tw 3.754 0 Td [( C)1.2(li)3.9(n)1.7(i)-1.8(c)3.2(a)-4.5(l c)-2.4(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.2(e)-12.9(d i)3.9(n )]TJ 0 Tw -3.754 -1.2 Td [(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.1(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 693.5811 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 653.5618 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 229.8563 693.5811 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 653.5618 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 292.2185 653.5618 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 653.3118 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 622.9006 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 653.3118 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 622.9006 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 292.2185 622.9006 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 622.6506 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 601.8393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 229.8563 622.6506 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 601.8393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 601.8393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 601.5893 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 580.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 229.8563 601.5893 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 580.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 580.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 580.528 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 550.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 580.528 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 550.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 292.2185 550.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 549.8667 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 538.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 549.8667 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 538.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 538.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 538.4054 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 527.1942 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 538.4054 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 527.1942 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 527.1942 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 526.9442 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 526.9442 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 130.3145 670.5464 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 13.178 1.8 Td (\026\217\r \212\004\204\t\r\b\003\013, )Tj 0.384 -1.2 Td (\220\f\211\201\r\b\b\013\r )Tj -0.655 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r)Tj 2.046 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj /T1_1 1 Tf -21.998 -1.433 Td (\215\024\035)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\240\036\027\f\022\017\005)Tj T* (\204\031\032\f\022\024\005)Tj 20.114 1.2 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(53,3%\))Tj T* (28)Tj /Span<>> BDC ( )Tj EMC (\(46,7%\))Tj -21.177 -1.433 Td (\200\024\030\026\f\021, \035\036\021, )Tj /T1_0 1 Tf (Me \(Q1; Q3\))Tj 0 -1.2 TD (Min\231Max)Tj /T1_1 1 Tf 20.1 1.2 Td (46,5)Tj /Span<>> BDC ( )Tj EMC (\(39,0; 55,5\))Tj 2.008 -1.2 Td (32\22666)Tj -22.108 -1.433 Td (\230\204\221, \022\020/\n)Tj 4.664 0 0 4.664 106.0864 595.6266 Tm (2)Tj 8 0 0 8 108.4184 592.9626 Tm (, )Tj /T1_0 1 Tf (Me \(Q1; Q3\))Tj -4.308 -1.2 Td (Min\231Max)Tj /T1_1 1 Tf 20.1 1.2 Td (27,3)Tj /Span<>> BDC ( )Tj EMC (\(24,9; 31,1\))Tj 1.323 -1.2 Td (18,9\22640,6)Tj -21.423 -1.433 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \026\ \002\024\035\036\r\026\027\017\016, \n\036\f\016\006\t, )Tj /T1_0 1 Tf (Me )Tj 0 -1.2 TD (\(Q1; Q3\))Tj T* (Min\231Max)Tj /T1_1 1 Tf 21.627 1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(4; 13\))Tj 0.48 -1.2 Td (1\226112)Tj -22.108 -1.433 Td (\217\036\006\017\007\017\r\027\t\005 \b\026\030\026\022\021\036\030 \f\r\ \017\013\026)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj 21.177 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(16,7%\))Tj -21.177 -1.433 Td (\215\030\036\r\036\027\021\017\r\027\026\016 \035\017\020\026\021\031\030\ \026 )Tj /T1_0 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 21.177 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(22,0%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.02 Tw 8.82 0 0 9 70.8661 510.2249 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \217\024\025\031\021\025\013\027 \200\020\032\020\n\023\027\032\022\024\ \023\022\n\022 \205\004\202 \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \206\210\207\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 9 0 0 9 70.8661 499.4248 Tm [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0 Tw 3.337 0 Td [( M)0.8(a)-6.3(i)4(n s)0.5(o)-4(n)-2.4(o)-8.6(g)-1.5(r)3.3(a)-5.2(p)-1.1(h)1.7(i)-1.8(c c)-2.4(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(A)10(F o)-3.9(n TR)11.5(U)13.9(S)]TJ ET /GS2 gs q 1 0 0 1 70.8661 494.9229 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 454.9036 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 229.8563 494.9229 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 454.9036 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 292.2185 454.9036 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 454.6536 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 405.0424 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 229.8563 454.6536 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 405.0424 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 292.2185 405.0424 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 404.7924 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 355.1811 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 229.8563 404.7924 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 355.1811 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 292.2185 355.1811 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 354.9311 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 354.9311 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 130.3145 471.8883 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 13.178 1.8 Td (\026\217\r \212\004\204\t\r\b\003\013, )Tj 0.384 -1.2 Td (\220\f\211\201\r\b\b\013\r )Tj -0.655 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r)Tj 2.046 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj /T1_1 1 Tf -21.998 -1.433 Td (\210\021\027\024\001\036\027\017\036 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\024\n\031 )Tj T* (\f\235\017\027\022\021\036\030\031)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj -0.01 Tc 1.063 -1.2 Td (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 \(\023\024\r\036\ \030\b\027\024\f\021\027\026\016 \023\024\030\006\017\016\))Tj 0 Tc T* (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 \(\020\035\031\ \002\024\022\026\016 \023\024\030\006\017\016\))Tj T* (\233\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 20.364 2.4 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13,3%\))Tj -0.25 -1.2 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(18,3%\))Tj T* (41)Tj /Span<>> BDC ( )Tj EMC (\(68,3%\))Tj -21.177 -1.433 Td (\214\024\022\026\035\017\026\006\017\016 \r\027\031\021\030\036\027\027\ \036\020\024 \f\r\017\013\036\r\024\020\024 )Tj T* (\024\021\r\036\030\f\021\017\016)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\215\036\030\036\007\027\016\016)Tj T* (\207\024\022\024\r\026\016)Tj T* (\003\026\007\027\016\016)Tj 20.114 2.4 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(60,0%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\))Tj -0.25 -1.2 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(30,0%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.074 Tw 9 0 0 9 70.8661 338.2118 Tm [(\020\004\206\f\t\204\004 )0.6(5.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( )0.5(\225\020\032\020\n\023\027\032 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 10.123 0 Td [(\f\031\n\020\f\022\016\020\006\022\t )0.5(\b\025\031\235\025\013\200 )0.5(\016\020\023\027\n\031\021 )0.6(\(\033\031 )]TJ 0 Tw -10.123 -1.2 Td (\030\020\025\025\013\026 \206\210\207\002\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.059 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.032 Tw 3.355 0 Td [( L)-9.7(o)-12.5(c)3.2(a)-4.5(li)8(z)8.4(a)-9.2(t)-29.1(i)-1.4(o)-4(n a)-5.1(n)-4.8(d f)-13.4(e)-7.5(a)-9.2(t)-1.1(u)1.6(r)-2(e)-22(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-3(u)1.6(r)-9.1(u)-1.5(le)-7(n)-0.6(t e)-32.4(x)-32.5(t)-1.6(e)-7(n)3.7(s)-12.5(i)-1.4(o)-4(n)3.7(s \()61.4(a)-9.2(c)]TJ 0 Tw 20.915 0 Td (-)Tj 0.003 Tc -0.003 Tw -24.271 -1.2 Td [(c)5.8(ordi)6.9(n)2.4(g)3( to)]TJ /Span<>> BDC 3.956 0 Td ( )Tj EMC [(T)2.7(R)14.6(U)16.9(S)36.4(\))]TJ ET /GS2 gs q 1 0 0 1 70.8661 301.3098 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 261.2906 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 229.8563 301.3098 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 261.2906 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 292.2185 261.2906 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 261.0406 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 249.8293 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 261.0406 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 249.8293 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 249.8293 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 249.5793 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 238.368 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 249.5793 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 238.368 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 238.368 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 238.118 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 226.9067 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 238.118 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 226.9067 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 226.9067 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 226.6567 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 215.4455 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 226.6567 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 215.4455 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 215.4455 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 215.1955 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 203.9842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 215.1955 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 203.9842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 203.9842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 203.7342 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 192.5229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 203.7342 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 192.5229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 192.5229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 192.2729 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 181.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 192.2729 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 181.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 181.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 180.8116 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 169.6003 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 180.8116 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 169.6003 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 169.6003 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 169.3503 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 158.139 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 169.3503 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 158.139 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 158.139 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 157.889 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 157.889 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 8 0 0 8 77.7353 278.2752 Tm (\225\004\006\004\220\003\r\006 \t)Tj /Span<>> BDC ( )Tj EMC (\f\002\220\004\f\t\213\004\204\t\235 \n\b\002\005\b\013\216 \213\004\003\ \r\220\002)Tj 19.75 1.8 Td (\026\217\r \212\004\204\t\r\b\003\013, )Tj 0.384 -1.2 Td (\220\f\211\201\r\b\b\013\r )Tj -0.655 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r)Tj 0.546 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60, )Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf ( \(%\))Tj /T1_1 1 Tf -20.497 -1.433 Td (\204\027\024\032\036\f\021\r\036\027\027\t\036 \026\021\036\022\017 \(>\ )Tj /Span<>> BDC ( )Tj EMC (1\))Tj 21.557 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(38,3\))Tj -21.557 -1.433 Td (\215\024\007\022\024\032\027\t\005 \026\021\036\022)Tj 21.557 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(26,7\))Tj -21.557 -1.433 Td (\230\001\017\024\026\027\026\035\034\027\t\005 \026\021\036\022)Tj 21.557 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(35,0\))Tj -21.557 -1.433 Td (\217\036\021\030\024\030\036\022\021\026\035\034\027\t\005 \026\021\036\ \022)Tj 21.557 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(18,3\))Tj -21.557 -1.433 Td (\215\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\005 \026\021\ \036\022)Tj 21.807 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(15,0\))Tj -21.807 -1.433 Td (\204\036\032\f\235\017\027\022\021\036\030\027\t\005 \026\021\036\022)Tj 21.807 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13,3\))Tj -21.807 -1.433 Td (\215\024\007\f\035\017\017\f\021\t\005 \026\021\036\022)Tj 21.807 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,33\))Tj -21.807 -1.433 Td (\003\026\021\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005 \023\036\030\ \036\020\024\030\024\007\022\036)Tj 22.057 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,3\))Tj -22.057 -1.433 Td (\200\027\031\021\030\017\f\021\036\027\024\004\027\t\005 \026\021\036\022\ )Tj 22.057 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,0\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.2525 56.0378 Tm (74)Tj ET endstream endobj 1252 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.251 Tw 10 0 0 10 42.5197 456.9139 Tm [(\f\r\017\013\036\r\024\020\024 )0.6(\024\021\r\036\030\f\021\017\016 )0.5(\030\026\035\017\004\027\t\n\017 )0.6(\n\036\021\024\007\026\n\017, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.659 0 Td (\021\024\n )Tj 0 Tw -20.659 -1.218 Td (\004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\253\021\030\026\007\017\006\017\024\027\027\t\n\017\273.)Tj 0.071 Tw 0 -1.218 TD (\233\235\235\036\022\021\017\r\027\024\f\021\034 \253\021\030\026\007\017\ \006\017\024\027\027\t\b\273 \n\036\021\024\007\024\r, \027\036\f\024\n\027\ \036\027)Tj 0 Tw (-)Tj T* (\027\024, \r\t\001\036 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.23 Tw T* (\210\007\027\026\022\024 \030\017\f\022 \023\024\r\030\036\032\007\036\027\ \017\016 \026\023\017\030\026\021\036\035\034\027\024\020\024 \026\023\023\ \026\030\026\021 )Tj 0.111 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \007\026\027\027\t\b \f\023\ \024\f\024\002\024\r )Tj 0.012 Tw T* (\007\024\f\021\017\020\026\036\021 26%. \222\035\036\007\031\036\021 \024\ \021\n\036\021\017\021\034, \004\021\024 \020\027\024\005\027\t\036 \026\ \021\036\022\017 )Tj 0.221 Tw T* (\021\026\022\032\036 \n\024\020\031\021 \016\r\035\016\021\034\f\016 \024\ \021\027\024\f\017\021\036\035\034\027\t\n \023\030\036\023\016\021\f\021\ \r\017\036\n )Tj 0.233 Tw T* (\007\035\016 \023\030\017\n\036\027\036\027\017\016 \253\021\030\026\007\ \017\006\017\024\027\027\t\b\273 \n\036\021\024\007\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 )Tj 0.149 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.818 0 Td [(\004\036\n )0.6(\017\b )0.6(\007\030\036\027\017\030\024\r\026\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 10.398 0 Td [(\022\026\004\036\f\021\r\036 )0.6(1 )0.6(\220\021\026\023\026 )0.6(\035\036\004\036\027\017\016 )]TJ 0 Tw -11.216 -1.218 Td (\023\030\024\r\024\007\017\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (48\22665% \023\026\006\017\036\027\021\024\r.)Tj 0.113 Tw T* (\200 2022 \020\024\007\031 \r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 )Tj 0.208 Tw T* (\202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ \030\026\030\026\002\024\021\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036)Tj 0 Tw (-)Tj 0.014 Tw T* (\007\030\036\027 \f\023\024\f\024\002 \b\017\030\031\030\020\017\004\036\ \f\022\024\005 \035\017\022\r\017\007\026\006\017\017 \f\r\017\013\036\005\ \023\030\016)Tj 0 Tw (-)Tj 0.05 Tw T* (\n\024\005 \022\017\001\022\017 \n\036\021\024\007\024\n \023\036\030\036\ \n\036\013\036\027\017\016 \035\026\021\036\030\026\035\034\027\024\020\024\ \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\022\017\001\036\004\027\024\020\024 \035\024\f\022\031\021\026 [2\ 4].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 237.7099 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.195 Tw 10 0 0 10 42.5197 213.3539 Tm (\210\006\036\027\017\021\034 \220\235\235\036\022\021\017\r\027\024\f\021\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \b\017\030\031\030\020\017\004\ \036)Tj 0 Tw (-)Tj 0.091 Tw T* (\f\022\024\020\024 \n\036\021\024\007\026 \035\017\022\r\017\007\026\006\ \017\017 \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017\ \035\026)Tj 0 Tw (-)Tj 0.044 Tw T* [(\021\036\030\026\035\034\027\t\n )0.6(\023\030\016\n\024\022\017\001\036\004\027\t\n )0.6(\035\024\f\022\031\021\024\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 16.575 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f\024 )]TJ 0 Tw -16.575 -1.218 Td (\253\f\035\024\032\027\t\n\017\273 \f\r\017\013\026\n\017 \023\030\016\n\ \024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 140.2859 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.225 Tw 10 0 0 10 42.5197 115.9299 Tm (\212\035\016 \024\006\036\027\022\017 \220\235\235\036\022\021\017\r\027\ \024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \f\023\024\f\024)Tj 0 Tw (-)Tj 0.354 Tw T* (\002\026 \b\017\030\031\030\020\017\004\036\f\022\024\005 \035\017\022\r\ \017\007\026\006\017\017 \253\f\035\024\032\027\t\b\273 \f\r\017\013\036\ \005 )Tj 0.209 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \n\036\021\024\007\024\n \023\ \036\030\036\n\036\013\036\027\017\016 \035\026\021\036\030\026\035\034\027\ \024\020\024 )Tj 0.169 Tw T* [(\023\030\016\n\024\022\017\001\036\004\027\024\020\024 )0.6(\035\024\f\022\031\021\026 )0.6(\023\030\024\r\036\007\036\027\024 )0.5(\024\007\027\024\006\036\027\021\030\024\r\024\036 )]TJ 0.02 Tw 23.244 37.752 Td (\024\007\027\024\020\030\031\023\023\024\r\024\036 \023\030\024\f\023\036\ \022\021\017\r\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024)Tj 0 Tw (-)Tj 0.149 Tw T* [(\030\024\036 \r\022\035\033\004\036\027\t )0.5(60 \023\026\006\017\036\027\021\024\r )0.5(\f\024 \f\035\024\032\027\t\n\017 )0.5(\f\r\017\013\026\n\017 )]TJ 0.241 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017, \024\023\036\030\017\030\024\ \r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\027\024\016\002\030\016 )Tj 0 Tw T* (2022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\034 2025 \020\020.)Tj 0.144 Tw T* (\200 \020\030\031\023\023\036 \017\f\f\035\036\007\024\r\026\027\017\016\ \027\036\027\026\004\017\021\036\035\034\027\024 \023\030\036\024\002\035\ \026\007\026\035\017 )Tj 0.2 Tw T* (\032\036\027\013\017\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 32)Tj /Span<>> BDC ( )Tj EMC (\(53,3%\), \n\031\032\004\017\027 \002\t\035\024 28)Tj /Span<>> BDC ( )Tj EMC (\(46,7%\). )Tj -0.012 Tw T* (\200\024\030\026\f\021 \r\026\030\034\017\030\024\r\026\035 \024\021 32\ \007\024)Tj /Span<>> BDC ( )Tj EMC (66 \035\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (46,5 )Tj 0.003 Tw T* (\(39,0; 55,5\) \035\036\021, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \026\027\ \026\n\027\036\026 \026\002\024)Tj 0 Tw (-)Tj 0.052 Tw T* (\035\036\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 1 \007\024)Tj /Span<>> BDC ( )Tj EMC (112 \n\036\f\016\006\036\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (7 \(4,0; )Tj 0.165 Tw T* (13,0\). \212\030\036\027\017\030\031\033\013\017\036 \024\023\036\030\026\ \006\017\017 \(\035\017\020\026\021\031\030\026\) \002\t\035\017 \r\t)Tj 0 Tw (-)Tj T* (\023\024\035\027\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (13/60 \(22,0%\) \023\026\006\017\036\027\021\024\r \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj /T1_3 1 Tf 0 -2.436 TD (\215\027\023\031\030\013 \031\240\024\f\027\030\031\021\020\025\022\t \033\ \020\006\022\027\025\023\031\021)Tj /T1_1 1 Tf 0.148 Tw 0 -1.218 TD (\200 \030\026\n\022\026\b \017\f\f\035\036\007\024\r\026\027\017\016 \r\f\ \036\n \023\026\006\017\036\027\021\026\n \007\024)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 )Tj 0.16 Tw T* (\(\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (6 \n\036\f\016\006\036\r\) \024\023\036\030\026\021\017\r\027\024\020\024\ \035\036\004\036\027\017\016 )Tj 0.089 Tw T* [(\f\r\017\013\026 \023\030\016\n\024 \022\017\001\022\017 \n\036\021\024\007\ \024\n )0.5(\214\215\214 )0.5(\r\t\023\024\035\027\016\035\017 )0.5(\021\030\026\027\f)]TJ 0 Tw (-)Tj 0.222 Tw T* (\030\036\022\021\026\035\034\027\024\036 \031\035\034\021\030\026\r\031\ \022\024\r\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 )Tj 0.402 Tw T* [(\235\031\027\022\006\017\017 \026\023\017\030\026\021\036\035\034\027\024\ \020\024 )0.5(\026\023\023\026\030\026\021\026 \023\030\016\n\024\005 \022\017\001\022\ \017 )]TJ -0.009 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\235\017\027\022\021\036\030\024\n\036\021\030\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\t W)22(e)-18(xner. \200)]TJ /Span<>> BDC ( )Tj EMC (\030\026\n)Tj 0 Tw (-)Tj -0.024 Tw T* (\022\026\b \023\030\024\021\024\022\024\035\026 \027\026\002\035\033\007\ \036\027\017\016 \023\026\006\017\036\027\021\t \023\024\f\035\036 \024\023\ \036\030\026\006\017\017 )Tj 0.374 Tw T* [(\036\032\036\007\027\036\r\027\024 \023\030\024\b\024\007\017\035\017 )0.5(\024\006\036\027\022\031 \002\024\035\036\r\024\020\024 \f\017\027\007\030\ \024\n\026 )]TJ 0 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\r\017\031\026\035\034\027\024-\026\027\026\035\024\020\024\r\024\005 \001\ \022\026\035\036 \(\200\202\231\).)Tj /T1_3 1 Tf 1.74 Tw 0 -2.436 TD (\220\020\025\025\013\027 \023\032\020\025\024\032\027\n\023\020\f\017\025\ \031\b\031 \r\f\017\023\032\020\016\021\r\n\031\021\031\b\031 )Tj 0 Tw 0 -1.218 TD (\022\024\024\f\027\030\031\021\020\025\022\t)Tj /T1_1 1 Tf 0.159 Tw T* (\215\024 \007\026\027\027\t\n \031\035\034\021\030\026\r\031\022\024\r\024\ \020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.197 Tw T* [(\023\030\036\024\002\035\026\007\026\035\017 \023\026\006\017\036\027\021\ \t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\n\017 )0.5(\f\r\017)]TJ 0 Tw (-)Tj -0.04 Tw T* (\013\026\n\017 \(41)Tj /Span<>> BDC ( )Tj EMC (\(68,3%\)\). \221\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \027\026\002\035\033\007\036\027\ \017\005 )Tj 0.313 Tw T* (\026\235\017\022\f\017\030\024\r\026\027\t \020\027\024\005\027\t\036 \ \026\021\036\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\t\b )Tj 0.203 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r\026\b \017/\017\035\017 \022\017\001\036\004\027\024\005 \f\021\ \036\027)Tj 0 Tw (-)Tj 0.028 Tw T* (\022\036 \(39/60 \(65,0%\)\). \215\030\017\004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (23/39 \(38,3%\) \002\024\035\034\027\t\b )Tj 0 Tw T* (\017\n\036\035\017\f\034 \n\027\024\032\036\f\021\r\036\027\027\t\036 \026\ \021\036\022\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4,5\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\203\203\027\n\023\022\021\025\031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\240\027\016\031\033\020\024\025\031\024\023\017 \253\024\203\022\025\n\023\ \027\032\031\024\240\027\032\027\b\020\005\212\022\200\273 \026\027\023\031\ \030\031\021 \f\027\007\027\025\022\t \024\021\022\212\027\235 \033\032\t\ \026\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( E)25.6(f)-42.4(f)-13.4(e)-10.9(c)-32.3(t)-29.1(i)-2.9(v)2.3(e)-7(n)-2.4(e)-22(s)-10.5(s a)-5.1(n)-4.8(d s)3.5(a)-0.6(f)-13.4(e)-8.6(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)4.4(p)-1.1(h)1.7(i)3.9(n)-2.9(c)-32.4(t)-1.6(e)-6(r)22.3(-)-1.5(s)4.4(p)-6.3(a)-4.1(r)-39(i)3.9(n)-0.6(g t)-1.6(e)-10.9(c)-2.5(h)0.8(n)1.7(iq)-3(u)-3.2(e)-21.9(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)-2(e)-7.4(a)-9.2(t)-10.6(m)-5.3(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5.1(na)-4.5(l \243)6.4(s)-14.8(t)-1.1(u)-1.6(l)-1(a)-7.2(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 178.8327 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 258.2028 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 337.5728 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 416.9429 715.181 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 684.5118 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 684.5118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 684.5118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 684.5118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 684.5118 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 673.0505 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 673.0505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 673.0505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 673.0505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 673.0505 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 661.5892 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 661.5892 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 661.5892 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 661.5892 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 661.5892 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 650.1279 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 650.1279 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 650.1279 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 650.1279 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 650.1279 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 638.6666 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 638.6666 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 638.6666 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 638.6666 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 638.6666 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 627.2053 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 627.2053 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 627.2053 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 627.2053 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 627.2053 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 615.744 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 615.744 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 615.744 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 615.744 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 615.744 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 604.2828 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 178.8327 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 416.9429 604.2828 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 100.1613 696.9464 Tm (\215\r\003\002\240)Tj 11.383 0.6 Td (\231\226\226\r\220\003\t\b\002\217\003\001)Tj 0.414 -1.2 Td (\(Min\232Max, %\))Tj 8.485 1.8 Td (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\004\235 )Tj 3.575 -1.2 Td (\025\032\255)Tj -2.139 -1.2 Td (\(Min\232Max, %\))Tj 9.436 1.8 Td (\027\b\002\005\b\013\r \213\004\003\r\220\t)Tj 0.486 -1.2 Td (\(Min\232Max, %\))Tj 9.804 1.8 Td (\200\006\r\r\b\003\t\b\004\235 )Tj 1.179 -1.2 Td (\f\t\n\004\003\210\006\004)Tj -1.061 -1.2 Td (\(Min\232Max, %\))Tj /T1_1 1 Tf -48.381 -1.433 Td (LIFT [1,2,3])Tj 20.336 0 Td (28\22694)Tj 10.171 0 Td (1\22623)Tj 10.699 0 Td (6)Tj 9.671 0 Td (43)Tj -50.878 -1.433 Td (VAAFT [4,5])Tj 20.336 0 Td (22\22687)Tj 10.523 0 Td (0-1)Tj 10.347 0 Td (2)Tj 9.671 0 Td (39)Tj -50.878 -1.433 Td (\205\017\002\030\017\027\024\r\t\005 \022\035\036\005 [6,7])Tj 20.336 0 Td (42\22679)Tj 10.949 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (68)Tj -50.878 -1.433 Td (\204\222\025 [8,9])Tj 20.086 0 Td (27\226100)Tj 11.199 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (59)Tj -50.878 -1.433 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n\023\035\026\027\021 \ [10,11])Tj 20.336 0 Td (20\22688)Tj 10.949 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (73)Tj -50.878 -1.433 Td (OTSC [12,13])Tj 20.336 0 Td (38\22665)Tj 10.949 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (98)Tj -50.878 -1.433 Td (FiLaC [14,15])Tj 20.336 0 Td (30\22682)Tj 10.171 0 Td (0\22610)Tj 10.699 0 Td (0)Tj 9.671 0 Td (81)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 587.5635 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\203\203\027\n\023\022\021\025\031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\240\027\016\031\033\020\024\025\031\024\023\017 \253\023\032\020\030\022\ \006\022\031\025\025\013\200\273 \026\027\023\031\030\031\021 \f\027\007\ \027\025\022\t \024\021\022\212\027\235 \033\032\t\026\031\235 \n\022\213\ \n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( E)25.6(f)-42.4(f)-13.4(e)-10.9(c)-32.3(t)-29.1(i)-2.9(v)2.3(e)-7(n)-2.4(e)-22(s)-10.5(s a)-5.1(n)-4.8(d s)3.5(a)-0.6(f)-13.4(e)-8.6(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)3.3(a)-8.7(d)-3(i)-3.4(t)-29.1(i)-1.4(o)-3.9(na)-4.5(l m)-5.3(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.7(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)-2(e)-7.5(a)-9.1(t)-10.6(m)-5.3(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5.1(na)-4.5(l \243)6.4(s)-14.8(t)-1.1(u)-1.6(l)-1.1(a)-7.1(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 572.2615 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 178.8327 572.2615 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 258.2028 572.2615 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 337.5728 572.2615 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 416.9429 572.2615 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 541.5923 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 541.5923 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 541.5923 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 541.5923 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 541.5923 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 530.131 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 178.8327 530.131 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 258.2028 530.131 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 530.131 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 416.9429 530.131 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 509.0698 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 178.8327 509.0698 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 258.2028 509.0698 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 509.0698 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 416.9429 509.0698 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 488.0085 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 178.8327 488.0085 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 488.0085 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 488.0085 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 416.9429 488.0085 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 100.1613 554.027 Tm (\215\r\003\002\240)Tj 11.383 0.6 Td (\231\226\226\r\220\003\t\b\002\217\003\001)Tj 0.414 -1.2 Td (\(Min\232Max, %\))Tj -0.233 Tw 8.485 1.8 Td (\200\002\217\f\r)Tj /Span<>> BDC ( )Tj EMC (\002\212\r\006\004\204\t\002\b\b\004\235 )Tj 0 Tw 3.575 -1.2 Td (\025\032\255)Tj -2.139 -1.2 Td (\(Min\232Max, %\))Tj 9.436 1.8 Td (\027\b\002\005\b\013\r \213\004\003\r\220\t)Tj 0.486 -1.2 Td (\(Min\232Max, %\))Tj 9.804 1.8 Td (\200\006\r\r\b\003\t\b\004\235 )Tj 1.179 -1.2 Td (\f\t\n\004\003\210\006\004)Tj -1.061 -1.2 Td (\(Min\232Max, %\))Tj /T1_1 1 Tf -48.381 -1.433 Td (\253\217\036\032\031\013\026\016\273 \035\017\020\026\021\031\030\026 [1\ 6,17])Tj 20.336 0 Td (70\22693)Tj 10.171 0 Td (8\22622)Tj 10.699 0 Td (0)Tj 9.921 0 Td (0)Tj -51.128 -1.433 Td (\230\f\f\036\004\036\027\017\036 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n )Tj T* (\f\235\017\027\022\021\036\030\026 [18\22621])Tj 20.336 1.2 Td (84\22696)Tj 10.171 0 Td (7\22627)Tj 10.671 0 Td (\226)Tj 9.699 0 Td (48)Tj -50.878 -2.633 Td (\215\030\016\n\024\022\017\001\036\004\027\t\005 \(\023\030\024\022\f\017\ \n\026\035\034\027\t\005\) )Tj T* (\035\024\f\022\031\021 [22,23])Tj 20.336 1.2 Td (55\22699)Tj 10.171 0 Td (0\22625)Tj 10.449 0 Td (35)Tj 9.921 0 Td (65)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8768 56.0378 Tm (73)Tj ET endstream endobj 1251 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 337.5706 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 337.5706 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 300.3627 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 300.3627 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 246.2935 cm 0 0 m 453.543 0 l S Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 141.2594 723.8861 Tm [(Displaced later)21(al r)31(ectal flap for anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 699.3822 Tm [(Timur\022)-23.2(V)62(.\022)-23.3(Nikishin)]TJ 8.162 0 0 8.162 164.0419 704.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 168.6778 699.3822 Tm [(, Iv)10(an\022)-23.3(V)62.1(.\022)-23.3(K)40.9(ostar)31.1(e)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 266.9692 704.0442 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 278.2899 699.3822 Tm [(, Ale)21(x)11(ander\022)-23.2(Y)40(u.\022)-23.3(Titov)]TJ 0 Tw 8.162 0 0 8.162 395.5783 704.0442 Tm (1)Tj 14 0 0 14 400.2143 699.3822 Tm (, )Tj -23.525 -1.143 Td [(Maria\022)-23.2(A)-31(.\022)-23.3(Ignatenk)11(o)]TJ 8.162 0 0 8.162 181.3885 688.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 186.0245 683.3822 Tm [(, Ev)10(geny\022)-23.2(E.\022)-23.3(Zhark)11(ov)]TJ 0 Tw 8.162 0 0 8.162 298.9875 688.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 303.6234 683.3822 Tm [(, Ikr)20(omzh)11(on\022)-23.2(I.\022)-23.3(Dadash)11(e)11(v)]TJ 0 Tw 8.162 0 0 8.162 440.9465 688.0442 Tm (2)Tj 14 0 0 14 445.5825 683.3822 Tm (, )Tj -26.765 -1.143 Td [(Oleg\022)-23.3(M.\022)-23.2(Bir)-31(y)10(uk)11(ov)]TJ 8.162 0 0 8.162 170.4967 672.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 175.1327 667.3822 Tm [(, Anastasia\022)-23.2(E.\022)-23.3(P)10(er)20(shina)]TJ 0 Tw 8.162 0 0 8.162 302.5706 672.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 307.2065 667.3822 Tm [(, Andr)31(ey\022)-23.2(A)-31(.\022)-23.3(Mudr)20(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 420.8833 672.0442 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 653.043 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 649.713 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 641.043 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 637.713 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, bld. 1)69(, Moscow)22(, )]TJ -0.331 -1.2 Td [(1)125(2)23(5)23(99)35(3, Russia\))]TJ /T1_1 1 Tf 0.042 Tw 9 0 0 9 119.0551 607.209 Tm [(AIM: ev)16(aluating ef)-39.9(fectiv)13(eness and safety of the method of f)-43(istula repair using a lateral rectal f)-22(lap in patients with )]TJ 0.023 Tw 0 -1.111 TD [(anal f)-43(istulas in)11(v)13(olving more than 1/3 of the e)-15(xter)-13.9(nal sphincter \(com)16(ple)-15(x anal f)-43(istulas\).)]TJ 0.012 Tc 0.111 Tw T* [(P)45(A)45(TIENT)-10(S A)53(ND METHODS: a sing)13(le-centre, p)46(rospectiv)13(e, sing)13(le-g)14(roup study included 60 patients who under)-32(w)12(ent)12.1( )]TJ 0.065 Tw T* [(anal f)-43(istula repair using a lateral rectal f)-22(lap \(LRF\). The check)32(-up before and af)-46(ter the surg)12(er)-43(y w)12.9(as car)-16(r)-37(ied out)12( )]TJ -0.014 Tw T* (using instrumental methods)Tj /Span<>> BDC ( )Tj EMC [(\227 transrectal ultrasound \(TR)27(US\) and sphincterometr)-43(y)32(. The ma)10(jor)-37(ity of patients had)12( )]TJ -0.001 Tw 0 -1.111 TD [(an e)-15(xtrasphincter)-37(ic f)-43(istula \(41/60 \(68.3%\)\), pararectal cavities w)12(ere detected in 39/60 \(65%\) patients, includ)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.03 Tw 0 -1.111 TD [(ing multiple cavities in 23/39 \(38.3%\). The late results w)12(ere studied af)-46(ter 3\23112)]TJ /Span<>> BDC ( )Tj EMC [(months. The median follow-up)12( )]TJ 0.14 Tw T* [(w)13(as 7 \(4; 8\) months. The p)46(r)-37(imar)-43(y endpoint w)13(as the rate of non-recur)-16(rence cases \(treatment ef)-40(fectiv)13(eness\),)12( )]TJ 0.125 Tw T* [(the second)26(ar)-43(y ones w)12(ere the assess)33(ment of continence, pain syndrome, r)-37(isk factors for unsatisfactor)-43(y results)12( )]TJ -0.012 Tw T* [(\(recur)-16(rence\).)]TJ 0.008 Tc 0.035 Tw T* [(RESUL)30(T)-10(S: )0.6(the )0.6(ef)-40(fectiv)13(eness )0.6(of )0.5(the )0.6(LRF )0.6(method )0.6(w)13(as )0.5(48/60 )0.6(\(80%; )0.6(95% )0.5(CI )0.6(67.7; )0.5(89.2\) )0.6(cases. )0.6(Sphincterometr)-43(y )0.5(and)8( )]TJ 0.073 Tw T* [(W)30(e)-15(xner\222)37(s )0.5(incontinence )0.6(scale )0.5(show)12(ed )0.5(no )0.5(w)12(orsening )0.5(of )0.5(continence )0.5(af)-46(ter )0.6(surgical )0.5(treatment )0.6(\(1 )0.5(\(0; )0.5(3\) )0.6(point )0.6(before)8( )]TJ 0.053 Tw T* [(the surg)12(er)-42.9(y and 2 \(0; 3\) points af)-46(ter 3\2316)]TJ /Span<>> BDC ( )Tj EMC (months \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.68\)\). The assess)33(ment of r)-36.9(isk factors for unsatisfactor)-43(y)8( )]TJ -0.024 Tw T* [(results )0.5(of )0.5(LRF )0.5(application )0.5(rev)13(ealed )0.5(such )0.5(factors )0.5(as )0.5(e)-15(xcess )0.5(body )0.5(w)12(eight )0.5(\(body )0.5(mass )0.5(inde)-15(x)]TJ /Span<>> BDC ( )Tj EMC 34.642 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC 0.725 0 Td [(30.7 )0.5(k)15(g/m\262\) )0.5(\(body )0.5(mass)8( )]TJ 0.096 Tw -35.366 -1.111 Td [(inde)-15(x)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(30.7 k)15(g/m\262\) \(odds ratio \(OR\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.14 \(95% coincidence inter)-42(v)16(al \(CI\) 1.02; 1.29\), p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.02\); purulent)8( )]TJ 0.057 Tw T* [(intersphincter)-37(ic leak)-23(s \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5.50 \(95% CI 1.14; 26.6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.03\); purulent ischioanal leak)-23(s\(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(16.8 \(95% CI)8( )]TJ 0.051 Tw T* (3.20; 7.55\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.0009\) and purulent pelviorectal leak)-22.9(s\(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7.86 \(95% CI 1.69; 36.6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.008\), as w)12(ell as)7.9( )]TJ 0.067 Tw 0 -1.111 TD (multiple purulent cavities \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4.40 \(95% CI 1.14; 16.9\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.03\).A)14(t the same time, the LRF method allows)8( )]TJ 0.104 Tw 0 -1.111 TD [(to achiev)13(e recov)13(er)-43(y in 28/39 \(71.8%\) patients with solitar)-43(y cavities, and in 15/23 \(65.2%\) cases of multiple)8( )]TJ -0.008 Tw T* (cavities.)Tj 0 Tc 0 Tw T* [(C)21(ON)22(CLUSION: the LRF method allows for the one-stag)12.1(e elimination of \244com)16(ple)-15(x\245 anal f)-43(istulas in 80% of cases, with)]TJ (-)Tj -0.005 Tw T* [(out w)12(orsening of anal continence. According to the Visual Analogue Scale, the\ median score did no)13(t e)-15(xceed 3 for the )]TJ -0.007 Tw T* [(entire follow-up per)-37(iod, what cor)-15.9(responds to a low lev)13(el of pain; at the same time, the maximum intensity w)13(as no)13(ted )]TJ 0.023 Tw T* (on the 2\2314)Tj /Span<>> BDC ( )Tj EMC [(d)25.9(ays af)-46(ter surg)12(er)-43(y)42(, whereas by the 10 d)26(ay almost all patients did no)13(t e)-15(xper)-37(ience pain.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 361.9398 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( anal f)-43(istula, RF)105(, lateral rectal f)-22(lap, LRF)105(, anal incontinence, AI)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.013 Tc -0.046 Tw -9.871 -2.617 Td [(F)3.5(O)-4.4(R)9( C)-17.2(I)-15.3(T)45.6(A)37.8(T)-24.2(I)-1.1(ON:)]TJ /T1_3 1 Tf -0.001 Tc -0.037 Tw 6.083 0 Td [( N)-13.2(i)-6.4(k)-40.8(i)-7.2(s)-8.5(h)-13.7(i)-3(n)]TJ /Span<>> BDC ( )Tj EMC [(T)52.7(.)40.9(V)39.9(.)-23.2(, K)-10.9(o)-15.6(s)-29(t)-36.6(a)-9.9(r)-18.8(e)-15.6(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.1(.)40.9(V)39.9(.)-23.2(, T)-17(i)-15.5(t)-21.7(o)-10(v A)-22.7(.)51.9(Y)12.8(u)-8.7(.)-23.3(, I)-4.5(g)-8.5(n)-7.5(a)-18(t)-24.4(e)-11.3(n)-8.5(k)-3.5(o)]TJ /Span<>> BDC ( )Tj EMC [(M)-6.9(.)-23.6(A)-22.7(.)-23.3(, Z)-19.4(h)-8(a)-10(r)-30.5(k)-3.5(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.4(.)0.7(E)-5.3(.)-23.3(, D)-11.5(a)-12.8(d)-9(a)-26.3(s)-8.6(h)-14.8(e)-15.6(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.1(.)-9.5(I)-10(.)-23.3(, B)-14.7(i)-5.7(r)-60.3(y)-21.3(u)-9.3(k)-3.5(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.7(.)-7(M)-6.9(.)-23.2(, P)-3.9(e)-11.9(r)-30(s)-8.5(h)-13.8(i)-2.9(n)-7.6(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.8(.)0.7(E)-5.3(.)-23.3(, M)-5.5(u)-10.1(d)-10.2(r)-15.5(o)-10.1(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.7(.)-23.7(A)-22.7(.)-1( )]TJ 0.009 Tc -0.035 Tw -6.088 -1.2 Td [(D)-30.3(i)-7.3(s)-9.3(p)-20.1(l)-37.8(a)-11(c)-9.7(e)-21(d l)-37.7(a)-18.2(t)-24.7(e)-12.1(r)-30.7(a)-11.4(l r)-19.1(e)-19(c)-41.5(t)-36.8(a)-11.3(l f)-47.1(l)-37.7(a)-8.8(p f)-25.2(o)-11.8(r a)-7.6(n)-7.8(a)-11.4(l f)-62.9(i)-7.4(s)-29.3(t)-22.2(u)-8.4(l)-37.7(a)-26.6(s)-15.5(. )]TJ /T1_1 1 Tf 0.019 Tc -0.019 Tw [(K)13.9(ol)3.6(op)2.4(r)3.2(o)3.4(k)-19.2(t)2.3(ol)3.6(o)-3.3(g)-13.1(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.009 Tc -0.035 Tw 25.759 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)20(;)9.8(2)-1.4(5)1(\()37.7(1)44.3(\))14.5(:)29.3(7)12.7(1)26.4(\226)-23.7(8)-23.3(0)6.5(. \()-0.9(i)-3.2(n R)-6.4(u)-21.9(s)-22.3(s)-15.4(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.6(s)-8(:)1.9(/)84.7(/)36.5(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.7(/)11.2(1)14(0)6.6(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.7(8/)7.9(2)-8.9(0)9.4(7)-1.9(3)-13.3(-)41.2(7)10.8(55)-8.9(6)-26.7(-)9.8(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)]TJ -0.004 Tc 0.004 Tw -25.759 -1.2 Td [(2)-28.4(5)-50.5(-)28.1(1-)14.2(7)-14.4(1-)-52.2(8)-50.4(0)]TJ /T1_2 1 Tf 0.01 Tc -0.041 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc -0.036 Tw 10.46 0 Td ( \001\022\n\022\213\022\025 \022\026\r\032 \211\f\020\030\022\026\022\032\ \031\021\022\007, \214\216\221\210 \253\001\215\002\037 \n\031\f\031\033\ \032\031\n\023\031\f\031\b\022\022 \022\026\027\025\022 \003.\001.)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 )Tj 0.023 Tw -10.465 -1.2 Td (\003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: timur\ nikishin@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.012 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.017 Tw 14.038 0 Td [( Timur V)61(. Nikishin, Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46(roctology Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.043 -1.2 Td [(123423, R)22(ussia; e-mail: timur)-14(nikishin@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 05.12.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 05.12.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 188.9979 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.006 Tc 0.138 Tw 10 0 0 10 70.8661 164.6418 Tm [(\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \r\f\036 \n\036\ \021\024\007\t )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.109 Tw 0 -1.218 TD (\004\036\027\017\016 \253\f\035\024\032\027\t\b\273 \f\r\017\013\036\005\ \023\030\016\n\024\005 \022\017\001\022\017 \n\024\032\027\024 \031\f)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.327 Tw T* (\035\024\r\027\024 \030\026\007\036\035\017\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\007\r\036 \020\030\031\023\023\t. \025\024\027\006\036\023\021\031\026\035\ \034\027\024\005)6( )]TJ 0.13 Tw T* (\024\f\024\002\036\027\027\024\f\021\034\033 \f\024\r\030\036\n\036\027\027\ \t\b, \021\026\022 \027\026\t\r\026\036\n\t\b \f\235\017\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.446 Tw T* [(\022\021\036\030\024\f\002\036\030\036\020\026\033\013\017\b, )0.5(\n\036\021\024\007\024\r )0.5(\016\r\035\016\036\021\f\016 )0.5(\023\030\036\r\026\035\017\030\024)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.372 Tw T* (\r\026\027\017\036 \r\026\032\027\024\f\021\017 \023\024\035\027\024\005\ \017\027\021\026\022\021\027\024\f\021\017 \026\023\017\030\026\021\036\ \035\034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.229 Tw T* [(\027\024\020\024 \026\023\023\026\030\026\021\026 \023\030\016\n\024\005\ \022\017\001\022\017 \027\026\007 \030\026\007\017\022\026\035\034\027\024\ \f\021\034\033)6( )]TJ 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0 Tc 0.205 Tw 23.244 10.96 Td [(\221\026\022\017\n )0.5(\024\002\030\026\024\n, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.385 0 Td [(\023\030\036\007\f\021\026\r\035\036\027\027\024\005 )0.6(\021\026\002\035\017\006\t )0.6(\r\017\007\027\024, )]TJ 0.506 Tw -8.385 -1.218 Td (\004\021\024 \f\024\r\030\036\n\036\027\027\t\036 \f\235\017\027\022\021\ \036\030\024\f\002\036\030\036\020\026\033\013\017\036 \n\036\021\024\007\ \t )Tj 0.008 Tw T* (\002\036\024\023\026\f\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\021\030\026\r\n\026\021\017\004\027\t \007\035\016 \003\202\215\ \025, \024\007\027\026\022\024 \017\b \220\235)Tj 0 Tw (-)Tj 0.111 Tw T* (\235\036\022\021\017\r\027\024\f\021\034 \024\f\021\026\r\035\016\036\021\ \032\036\035\026\021\034 \035\031\004\001\036\020\024. \025\030\024\n\036\ \021\024\020\024, )Tj 0.063 Tw T* [(\f\031\013\036\f\021\r\036\027\027\t\n )0.6(\024\020\030\026\027\017\004\036\027\017\036\n )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 13.208 0 Td [(\r\024\n\024\032\027\024\f\021\017 )0.6(\017\b )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.184 Tw -13.208 -1.218 Td (\n\036\027\036\027\017\016 \024\f\021\026\033\021\f\016 \020\027\024\005\ \027\t\036 \026\021\036\022\017; \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\n )Tj 0.26 Tw T* [(\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036 \021\030\ \036\002\031\036\021\f\016 )0.5(\n\027\024\020\024\220\021\026\023\027\024\036 \035\036\004\036)]TJ 0 Tw (-)Tj 0.089 Tw T* (\027\017\036 \(\007\030\036\027\017\030\031\033\013\026\016 \035\017\020\ \026\021\031\030\026\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036, \023\024-\023\030\036\032\027\036\n\031, )Tj 0.621 Tw T* (\027\036\024\002\b\024\007\017\n\024 \023\030\024\r\036\007\036\027\017\036\ \024\021\007\036\035\034\027\024\020\024 \021\030\026\027\f\026\027\026\ \035\034)Tj 0 Tw (-)Tj 0.35 Tw T* (\027\024\020\024 \220\021\026\023\026 \024\023\036\030\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \035\017\022\r\017\007\026\006\017\017 \r\027\031\021\030\036\027\027\ \036\020\024 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 615.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 73.5728 606.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.165 56.0378 Tm (72)Tj ET endstream endobj 1248 0 obj [1257 0 R] endobj 1249 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 167.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 167.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 130.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 130.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-71-80)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 96.0909 695.3259 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 )]TJ -0.607 -1.105 Td [(\212\017\202\t\004\013)10(\025 \224\005\025\220\025\202\017 \224\004\005\004\024\004\234\004\t\t\217\ \024 \020\017\026)11(\004\005\017\020\200\t\217\024 )]TJ 0 Tw 4.291 -1.105 Td [(\224\005\213\024\025\r\n\204\004\225\t\217\024\022)-23.2(\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\007\n\r\n\204\n\t\022)-23.2(\032.\021.)]TJ 8.162 0 0 8.162 119.9147 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 124.5506 628.822 Tm [(, \037)31(\025\016)-10(\026)11(\017\005\004\b\022)-23.2(\030.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 214.4659 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 225.7865 628.822 Tm [(, \032)30(\n\026)11(\025\b\022)-23.2(\f)-31(.\207.)]TJ 0 Tw 8.162 0 0 8.162 299.3217 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 303.9577 628.822 Tm [(, \030\013\t\017\026)11.1(\004\t\r)10(\025\022)-23.3(\235.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 405.1283 633.484 Tm (1)Tj 14 0 0 14 409.7642 628.822 Tm (, )Tj -26.232 -1.143 Td [(\223)42(\017\005\r)10(\025\b\022)-23.3(\240.\240.)]TJ 8.162 0 0 8.162 112.9153 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 117.5513 612.822 Tm [(, \201\017\202\017\204\004\b\022)-23.2(\030.\030.)]TJ 0 Tw 8.162 0 0 8.162 209.6504 617.484 Tm (2)Tj 0.023 Tw 14 0 0 14 214.2863 612.822 Tm [(, \006\n\005\206\r)10(\025\b\022)-23.2(\036.\235.)]TJ 0 Tw 8.162 0 0 8.162 307.3653 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 312.0013 612.822 Tm [(, \034\004\005\204\n\t\017\022)-23.2(\f)-31(.\240.)]TJ 0 Tw 8.162 0 0 8.162 401.8464 617.484 Tm (1)Tj 14 0 0 14 406.4824 612.822 Tm (, )Tj -25.997 -1.143 Td [(\235\002\202\005\025\b\022)-23.2(\f)-31(.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 118.9066 601.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 42.5197 582.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 579.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 558.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 555.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0.058 Tw 9 0 0 9 90.7087 536.6488 Tm [(\037\036\035\034 )0.6(\002\205\205\035\036\220\217\211\003\001\002\226: )0.6(\031\006\027\025\n\020 )0.6(\204\203\203\027\n\023\022\021\025\031\024\023\022 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 20.683 0 Td [(\240\027\016\031\033\020\024\025\031\024\023\022 )0.7(\200\022\032\r\032\b\022\007\027\024\n\031\b\031 )0.5(\026\027\023\031\030\020 )0.5(\f\022\n\021\022\030\020\006\022\022 )0.5(\024\021\022\212\027\235 )]TJ 0.215 Tw -20.683 -1.111 Td (\033\032\t\026\031\235 \n\022\213\n\022 \f\020\023\027\032\020\f\017\025\ \013\026 \033\032\t\026\031\n\022\213\027\007\025\013\026 \f\031\024\n\r\ \023\031\026 \(\035\004\035\) \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024\031 \024\021\022\212\020\026\022\ \033\032\t\026\031\235 \n\022\213\n\022, )Tj 0.023 Tw 0 -1.111 TD (\021\031\021\f\027\n\020\005\212\022\026\022 \240\031\f\027\027 1/3 \025\ \020\032\r\255\025\031\b\031 \024\203\022\025\n\023\027\032\020 \(\030\020\ \f\027\027 \253\024\f\031\255\025\013\027\273 \024\021\022\212\022 \033\032\ \t\026\031\235 \n\022\213\n\022\).)Tj 0.338 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\006\027\025\023\032\031\021\031\027 \033\032\031\024\033\ \027\n\023\022\021\025\031\027 \031\030\025\031\b\032\r\033\033\031\021\031\ \027 \022\024\024\f\027\030\031\021\020\025\022\027 \240\013\f\031 \021\n\ \f\005\007\027\025\031 )Tj 0.05 Tw T* (60)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021, \n\031\023\031\032\013\026 \021\013\ \033\031\f\025\027\025\020 \f\022\n\021\022\030\020\006\022\t \024\021\022\ \212\020 \033\032\t\026\031\235 \n\022\213\n\022 \f\020\023\027\032\020\f\ \017\025\013\026 \033\032\t\026\031\n\022\213\027\007\025\013\026 \f\031\ \024\n\r)Tj 0 Tw (-)Tj 0.029 Tw 0 -1.111 TD [(\023\031\026. )0.5(\217\240\024\f\027\030\031\021\020\025\022\027 )0.5(\033\020\006\022\027\025\023\031\021 )0.5(\030\031)]TJ /Span<>> BDC ( )Tj EMC 14.409 0 Td (\022)Tj /Span<>> BDC ( )Tj EMC 0.761 0 Td [(\033\031\024\f\027 )0.5(\031\033\027\032\020\023\022\021\025\031\b\031 )0.5(\021\026\027\213\020\023\027\f\017\024\023\021\020 \033\032\031\021\031\030\ \022\f\031\024\017 )0.5(\033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\033\031\026\031\212\022 \022\025\024\023\032\r)Tj 0 Tw (-)Tj 0.095 Tw -15.17 -1.111 Td (\026\027\025\023\020\f\017\025\013\200 \026\027\023\031\030\031\021)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\032\020\025\024\032\027\n\023\020\f\017\025\031\b\031 )0.5(\r\f\017\023\032\020\016\021\r\n\031\021\031\b\031 )0.5(\022\024\024\f\027\030\031\021\020\025\022\t \(\206\210\207\002\) \022)]TJ /Span<>> BDC ( )Tj EMC (\024\203\022\025\n\023\027\032\031\026\027\023\032\022\022. )Tj -0.023 Tw 0 -1.111 TD [(\004\032\027\021\020\f\022\032\r\005\212\027\027 \n\031\f\022\007\027\024\ \023\021\031 \033\020\006\022\027\025\023\031\021 \022\026\027\f\022 \204\ \n\024\023\032\020\024\203\022\025\n\023\027\032\025\013\235 )0.5(\200\031\030 \024\021\022\212\020 41/60 \(68,3%\). \001\020\f\022\007\022\ \027 \b\025\031\235)]TJ 0 Tw (-)Tj 0.138 Tw T* (\025\031-\021\031\024\033\020\f\022\023\027\f\017\025\013\200 \016\020\023\ \027\n\031\021 \021\013\t\021\f\027\025\013 \r)Tj /Span<>> BDC ( )Tj EMC (39/60 \(65%\), \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \026\025\031\255\027\024\023\021\027\025\025\013\027 \016\ \020\023\027\n\022 \016\020\203\022\n\024\022\032\031\021\020\025\013 )Tj 0.009 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (23/39 \(38,3%\). \217\023\030\020\f\027\025\025\013\027 \032\027\016\r\f\ \017\023\020\023\013 \f\027\007\027\025\022\t \240\013\f\022 \022\016\r\007\ \027\025\013 \007\027\032\027\016 3\23112)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\t\006\027\021. \215\027\030\022\020\025\020 \025\020\240\f\005\ \030\027\025\022\t )Tj 0.096 Tw T* (\024\031\024\023\020\021\022\f\020 7 \(4; 8\) \026\027\024\t\006\027\021\ . \004\027\032\021\022\007\025\031\235 \n\031\025\027\007\025\031\235 \023\ \031\007\n\031\235 \240\013\f\020 \007\020\024\023\031\023\020 \025\027\025\ \020\024\023\r\033\f\027\025\022\t \032\027\006\022\030\022\021\020 \016\ \020\240\031\f\027)Tj 0 Tw (-)Tj 0.238 Tw T* [(\021\020\025\022\t )0.6(\(\204\203\203\027\n\023\022\021\025\031\024\023\017 )0.6(\f\027\007\027\025\022\t\), )0.5(\021\023\031\032\022\007\025\013\026\022)]TJ /Span<>> BDC ( )Tj EMC 20.816 0 Td [(\227 )0.5(\031\006\027\025\n\020 )0.5(\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 )0.6(\024\031\024\023\031\t\025\022\t )0.5(\016\020\033\022\032\020\023\027\f\017\025\031\b\031 )]TJ -0.033 Tw -20.816 -1.111 Td (\020\033\033\020\032\020\023\020 \033\032\t\026\031\235 \n\022\213\n\022\ ; \021\013\032\020\255\027\025\025\031\024\023\022 \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020; \203\020\n\023\031\032\031\021 \ \032\022\024\n\020, \033\032\027\030\033\031\f\031\255\022\023\027\f\017\ \025\031 \021\f\022\t\005\212\022\200 )Tj 0.023 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\027 \032\027\006\022\030\022\021\020.)Tj 0.044 Tw 0 -1.111 TD [(\206\036\207\210\035\034\003\201: )0.6(\204\203\203\027\n\023\022\021\025\031\024\023\017 )0.6(\026\027\023\031\030\020 )0.6(\035\004\035 )0.5(\024\031\024\023\020\021\022\f\020 )0.6(48/60 )0.5(\(80%; )0.6(95% )0.5(\220\002 )0.5(67,7; )0.5(89,2\) )0.5(\024\f\r\007\020\027\021. )0.5(\001\022 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 42.512 0 Td (\031\030\025\031\026 )Tj 0.305 Tw -42.512 -1.111 Td (\025\020\240\f\005\030\027\025\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\031\026 \033\027\ \032\022\031\030\027 \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \024\203\022\025\n\023\027\032\031\026\027\023\032\ \022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\027 \025\027\030\031\024\023\020\023\031\007\025\031\024\ \023\022 )Tj 0.162 Tw 0 -1.111 TD (\020\025\020\f\017\025\031\b\031 \024\203\022\025\n\023\027\032\020 \033\ \031)Tj /Span<>> BDC ( )Tj EMC (\213\n\020\f\027 Wexner \025\027 \016\020\203\022\n\024\022\032\031\021\020\ \025\031 \r\200\r\030\213\027\025\022\t \203\r\025\n\006\022\022 \030\027\ \032\255\020\025\022\t \(1 \(0; 3\) \240\020\f\f\020 )Tj -0.002 Tw T* (\030\031)Tj /Span<>> BDC ( )Tj EMC 1.208 0 Td [(\031\033\027\032\020\023\022\021\025\031\b\031 )0.5(\021\026\027\213\020\023\027\f\017\024\023\021\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 13.945 0 Td [(2 )0.5(\(0; )0.5(3\) )0.5(\240\020\f\f\020)]TJ /Span<>> BDC ( )Tj EMC 5.986 0 Td [(\227 )0.5(\007\027\032\027\016 )0.5(3\2316)]TJ /Span<>> BDC ( )Tj EMC 5.421 0 Td (\026\027\024. \(\032)Tj /Span<>> BDC ( )Tj EMC 3.067 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.731 0 Td [(0,68\)\). )0.6(\004\032\022)]TJ /Span<>> BDC ( )Tj EMC 4.859 0 Td [(\031\006\027\025\n\027 )0.6(\203\020\n\023\031\032\031\021 )0.5(\032\022\024\n\020 )]TJ 0.07 Tw -35.218 -1.111 Td (\032\020\016\021\022\023\022\t \032\027\006\022\030\022\021\020 \016\020\ \240\031\f\027\021\020\025\022\t \021\013\t\021\f\027\025\031, \007\023\031\ \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\ \026\031 \024\025\022\255\020\027\023 \204\203\203\027\n\023\022\021\025\ \031\024\023\017 \033\032\022\026\027)Tj 0 Tw (-)Tj 0.02 Tw T* (\025\027\025\022\t \035\004\035 \022\016\240\013\023\031\007\025\020\t \026\ \020\024\024\020 \023\027\f\020 \(\033\032\022 \022\025\030\027\n\024\027\ \026\020\024\024\013 \023\027\f\020)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (30,7 \n\b/\026\262\) \(\031\023\025\031\213\027\025\022\027 \213\020\025\ \024\031\021 \(\217\237\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,14 )Tj 0.048 Tw T* (\(95% \030\031\021\027\032\022\023\027\f\017\025\013\235 \022\025\023\027\ \032\021\020\f \(\220\002\) 1,02; 1,29\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\), \b\025\031\235\025\013\027 \016\020\023\027\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\026\027\255\024\203\022\025\n\023\027\032\025\031\026 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5,50 )Tj 0.002 Tw T* (\(95% \220\002 1,14; 26,6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\), \022\213\022\031\020\025\020\f\017\025\031\026 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (16,8 \(95% \220\002 3,20; 7,55\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0009\) \022)Tj /Span<>> BDC ( )Tj EMC (\033\027\f\017\021\022\031\032\027\n\023\020\f\017)Tj 0 Tw (-)Tj 0.08 Tw T* (\025\031\026 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7,86 \(95% \220\002 1,69; 36,6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \033\032\031\024\023\032\020\025\024\023\021\020\200, \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \026\025\031\255\027\024\023\021\027\025\025\013\027 \ \b\025\031\235\025\013\027 \016\020\023\027\n\022 )Tj 0.096 Tw 0 -1.111 TD (\(\217\237)Tj /Span<>> BDC ( )Tj EMC 2.102 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(4,40 )0.5(\(95% \220\002 )0.5(1,14; )0.5(16,9\), \032)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 13.536 0 Td [(0,03\). )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC [(\023\031 )0.5(\255\027 \021\032\027\026\t, )0.5(\026\027\023\031\030 )0.5(\035\004\035 )0.5(\033\031\016\021\031\f\022\f )0.5(\030\031\240\022\023\017\024\t \021\013\016\030\031\032\031\021\f\027\025\ \022\t )]TJ 0.052 Tw -15.638 -1.111 Td (\r)Tj /Span<>> BDC ( )Tj EMC (28/39)Tj /Span<>> BDC ( )Tj EMC (\(71,8%\) \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\b\025\031\235\025\013\026\022 \016\020\023\027\n\020\026\022, \033\032\022\ \007\027\026 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\022 \026\025\031\255\027\024\023\021\027\025\025\013\ \200 \016\020\023\027\n\031\021 \024\021\022\212 \r\030\020)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\f\031\024\017 \f\022\n\021\022\030\022\032\031\021\020\023\017 \021)Tj /Span<>> BDC ( )Tj EMC (15/23)Tj /Span<>> BDC ( )Tj EMC (\(65,2%\) \024\f\r\007\020\t\200.)Tj 0.096 Tw T* (\207\003\202\035\224\232\036\001\002\036: \026\027\023\031\030 \035\004\035\ \033\031\016\021\031\f\t\027\023 \031\030\025\031\204\023\020\033\025\031\ \f\022\n\021\022\030\022\032\031\021\020\023\017 \253\024\f\031\255\025\ \013\027\273 \024\021\022\212\022 \033\032\t\026\031\235 \n\022\213\n\022\ \021)Tj /Span<>> BDC ( )Tj EMC (80% )Tj 0.068 Tw T* (\025\020\240\f\005\030\027\025\022\235, \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026, \025\027 \r\200\r\030\213\020\t \203\r\025\n\006\022\031\ \025\020\f\017\025\031\b\031 \024\031\024\023\031\t\025\022\t \016\020\033\ \022\032\020\023\027\f\017\025\031\b\031 \020\033\033\020\032\020\023\020\ \033\032\t\026\031\235 \n\022\213\n\022. )Tj 0.124 Tw T* (\221\031\f\027\021\031\235 \024\022\025\030\032\031\026, \021)Tj /Span<>> BDC ( )Tj EMC (\024\032\027\030\025\027\026, \025\027 \033\032\027\021\013\213\020\f \253\ \024\f\020\240\031\b\031\273 \r\032\031\021\025\t \031\212\r\212\027\025\ \022\235, \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \021\022\016\r\020\f\017\025\031-\020\025\020\f\ \031\b\031\021\031\235 )Tj -0.025 Tw T* (\213\n\020\f\013 \240\031\f\022. \004\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \021\022\016\r\020\f\017\025\031-\020\025\020\f\ \031\b\031\021\031\235 \213\n\020\f\013 \240\031\f\022, \026\027\030\022\ \020\025\020 \240\020\f\f\031\021 \025\027 \033\032\027\021\013\213\020\f\ \020 3-\200 \016\020)Tj /Span<>> BDC ( )Tj EMC (\021\027\024\017 \033\027\032\022\031\030 )Tj 0.078 Tw T* (\025\020\240\f\005\030\027\025\022\t, \007\023\031 \024\031\031\023\021\027\ \023\024\023\021\r\027\023 \024\f\020\240\031\026\r \r\032\031\021\025\005\ \240\031\f\027\021\013\200 \031\212\r\212\027\025\022\235; \033\032\022\ )Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \026\020\n\024\022\026\020\f\017\025\020\t \022\025\023\ \027\025\024\022\021)Tj 0 Tw (-)Tj 0.051 Tw T* (\025\031\024\023\017 \240\013\f\020 \031\023\026\027\007\027\025\020 \025\ \020)Tj /Span<>> BDC ( )Tj EMC (2\2314)Tj /Span<>> BDC ( )Tj EMC (\024\r\023\n\022 \033\031\024\f\027 \031\033\027\032\020\006\022\022, \023\ \031\b\030\020 \n\020\n \n)Tj /Span<>> BDC ( )Tj EMC (10 \024\r\023\n\020\026 \033\032\020\n\023\022\007\027\024\n\022 \021\024\ \027 \033\020\006\022\027\025\023\013 \025\027 )Tj 0.023 Tw 0 -1.111 TD (\022\024\033\013\023\013\021\020\f\022 \240\031\f\027\021\013\200 \031\212\ \r\212\027\025\022\235.)Tj /T1_2 1 Tf 0.01 Tc -0.005 Tw 8 0 0 8 42.5596 201.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0 Tw 8.47 0 Td ( \024\021\022\212 \033\032\t\026\031\235 \n\022\213\n\022, \205\004\202,\ \f\020\023\027\032\020\f\017\025\013\235 \033\032\t\026\031\235 \n\022\213\ \027\007\025\013\235 \f\031\024\n\r\023, \035\004\035, \f\022\n\021\022\030\ \020\006\022\t \024\021\022\212\020 \033\032\t\026\031\235, \b\025\031\235\ \025\013\027 \016\020\023\027\n\022, )Tj 0.023 Tw -8.475 -1.2 Td (\033\032\027\021\027\025\023\022\021\025\020\t \f\022\b\020\023\r\032\020\ , \025\027\030\031\024\023\020\023\031\007\025\031\024\023\017 \020\025\020\ \f\017\025\031\b\031 \024\203\022\025\n\023\027\032\020, \001\003\205)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.017 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5.3( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.007 Tc -0.035 Tw 8.866 0 Td ( \203\017\022\017\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\200., \221\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \230\020\027\026\021\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \240\026\030\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\213., \212\026\007\026\001\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\230., \207\017\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \215\036\030\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC [(\202.\213.,)7( )]TJ 0.023 Tc -0.014 Tw -8.871 -1.2 Td (\204\031\007\030\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\202. \217\036\031\035\034\021\026\021\t \b\017\030\031\030\020\017\ \004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \f\r\017\013\036\ \005 \026\007\027\036\020\024 \023\030\024\b\024\007\026 \023\036\030\036\ \n\036\013\036\027\027\t\n \035\026\021\036\030\026\035\034\027\t\n \023\ \030\016\n\024\022\017\001\036\004\027\t\n \035\024\f\022\031\021\024\n.\ )23( )]TJ /T1_1 1 Tf -0.023 Tw 0 -1.2 TD (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (71\22680. https://doi.org/10.33878/2073-7556-2026-25-1-71-80)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 545.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 47.6607 536.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0519 56.0378 Tm (71)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 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(\025\024\n\026\030\024\r \212\n\017\021\030\017\005 \202\035\036\022\f\026\ \027\007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\031\007\036\027\021 6 \022\031\030)Tj 0 Tw (-)Tj 0.485 Tw T* (\f\026 \023\036\007\017\026\021\030\017\004\036\f\022\024\020\024 \235\026\ \022\031\035\034\021\036\021\026 \205\206\207\210\211 \200\210 \025\206\204\ \211 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0009-0008-11\ 42-5430)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(V)-15(ic)-16(t)17(or A. L)-31.9(a)-24(zar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2069-7701)Tj 0 -1.218 TD [(Dmi)-24(tr)-36.9(iy A. Sever)-36.9(inov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4460-1353)Tj 0 -1.218 TD [(V)-15(ia)-17(chesl)-15.9(av A. L)-32(ip)32(a)15(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6121-7412)Tj T* [(T)40(a)15(t)-10(y)22(ana N. K)25.1(udr)-24(y)22(av)-24(tsev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1009-3004)Tj T* [(Dmi)-24(tr)-23.9(y A. Sever)-36.9(inov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4460-1353)Tj T* [(Dmi)-24(tr)-23.9(y A. K)25(omar)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0008-1142-5430)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 566.5159 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.203 Tw 8 0 0 8 70.8661 553.6812 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(inst)17(on)]TJ /Span<>> BDC ( )Tj EMC [(DEM, P)-24(ina)]TJ /Span<>> BDC ( )Tj EMC [(N, K)-16(asp)25.1(r)-24(zyck)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew )]TJ -0.042 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.006 0 Td [(single-l)-15.9(a)15(yer )0.5(ver)-10(sus )0.5(d)-16(ouble-l)-16(a)15.1(yer intest)-31.9(inal )0.5(anast)17(omosis: )0.5(is )0.5(one be)-11.9(t)]TJ 0 Tw (-)Tj -1.006 -1.25 Td (ter? )Tj /T1_3 1 Tf -0.009 Tw 1.784 0 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surgical R)21.1(esearch)]TJ /T1_0 1 Tf [(. 2024;302:606\226610. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -1.784 -1.25 Td (jss.2024.07.105)Tj 0 0 0 1 k /GS1 gs 0.267 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC [(Anir)-21.9(ut)-13(han)]TJ /Span<>> BDC ( )Tj EMC [(D, P)35(r)-33(anav)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(AR, Sr)-24(eena)15(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC [(GS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.9(f)-28(ica)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC (sin)Tj 0 Tw (-)Tj 0.001 Tc 0.35 Tw T* [(gle l)-16.4(a)14.6(yer)-24.4(ed intest)-32.4(inal anast)16.6(omosis over d)-16.4(ouble l)-16.4(a)14.6(yer)-24.4(ed intest)-32.4(i)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.35 Tw T* [(nal anast)16.7(omosis-an open l)-16.3(abelled, r)-33.3(and)-16.3(omized contr)-32.3(olled tr)-37.3(ial.)6( )]TJ /T1_3 1 Tf 0 Tc 0.102 Tw T* [(Inter)-14(national Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf [(. 2020;78:173\226178. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ijsu.2020.04.066)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.372 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.326 0 Td (\202\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC 2.992 0 Td [(\233.\025., )0.5(\230\f\n\026\005\t\035\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 8.33 0 Td [(\003.\233., )0.5(\204\026\n\036\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.692 0 Td [(\221.\233. )0.6(\215\030\024\235\017\035\026\022\021\017\022\026)10( )]TJ 0 Tc 0.133 Tw -19.34 -1.25 Td [(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.5(\001\r\024\r \022\017\001\036\004\027\t\b \026\027\026\f\021\024\n\024\024\ \r. )]TJ /T1_3 1 Tf [(\001\031\021\031\024\023\022 )0.5(\200\022\032\r\032)]TJ 0 Tw (-)Tj 0.011 Tc -0.011 Tw T* (\b\022\022)Tj /T1_0 1 Tf 0.417 Tw [(. 2022;30\(1\):86\22694. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.18484/2305-0047.2022.1.86)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.428 Tw ( / )Tj 0.188 Tw T* [(A)-25(gha)15(yev)]TJ /Span<>> BDC ( )Tj EMC [(E.K., Is)26(ma)15(yil)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(Z.E., Mamed)-16(ov)]TJ /Span<>> BDC ( )Tj EMC [(T.E. P)35(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sutur)-24(e )]TJ 0.019 Tc 0.678 Tw T* [(insuf)-55.7(f)-27.7(ic)-23.6(iency in intest)-31.7(inal anast)17.3(omoses. )]TJ /T1_3 1 Tf [(N)17.3(ov)13.3(osti Khirurgii)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2022;30\(1\):86\22694. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18484/2305-0047.2022.1.86)Tj 0 0 0 1 k /GS1 gs 0.242 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(U)13(pp)32(al)]TJ /Span<>> BDC ( )Tj EMC [(A, P)-23.9(iga)-24(z)-24(zi)]TJ /Span<>> BDC ( )Tj EMC [(A. New technol)30.1(o)-16(gies t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(event anast)17(omo)17(t)-32(ic )]TJ 0 Tw -1.296 -1.25 Td (leak. )Tj /T1_3 1 Tf 0.18 Tw 2.345 0 Td [(Clin Colon R)21(ectal Surg)]TJ /T1_0 1 Tf [(. 2021;34\(6\):379\226384. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.813 0 Td (10.1055/s-)Tj -23.158 -1.25 Td (0041-1735268)Tj 0 0 0 1 k /GS1 gs -0.027 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(adu)]TJ /Span<>> BDC ( )Tj EMC [(ER, V)29(oicu)]TJ /Span<>> BDC ( )Tj EMC [(SI, T)47(hakur)]TJ /Span<>> BDC ( )Tj EMC [(VK. P)10(ol)35(ymer)-37(ic membr)-33(anes for biomedical )]TJ 0 Tw -1.296 -1.25 Td [(appl)-31(ica)15(t)-31.9(ions. )]TJ /T1_3 1 Tf 5.544 0 Td [(P)15(olymers)]TJ /T1_0 1 Tf 0.023 Tw (. 2023;15)Tj /T1_3 1 Tf 0 Tw (:)Tj /T1_0 1 Tf 0.023 Tw [(619. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/pol)35(ym15030619)]TJ 0 0 0 1 k /GS1 gs 0.017 Tc 0.62 Tw -5.544 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.347 0 Td (\037\t\023\035\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\025.\206., \212\036\027\017\f\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\214., \206\026\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 0.009 Tc 0.35 Tw -1.347 -1.25 Td (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \024\002\ \024\f\027\024\r\026\027\017\036 \023\030\017\n\036\027\036\027\017\016 \ \n\036\021\024\007\024\r \002\017\024\035\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.35 Tw T* (\020\017\004\036\f\022\024\005 \026\013\017\021\t \021\024\035\f\021\024\ \022\017\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026, \ \f\235\024\030\n\017\030\024\r\026\027)Tj 0 Tc 0 Tw (-)Tj 0.247 Tw T* (\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \035\026\023\026\030\024\f\022\024\023\017\004\ \036\f\022\017 \026\f\f\017\f\021\017\030\024\r\026\027\027\024\005 \024\ \023\036\030\026\006\017\017. )Tj /T1_3 1 Tf 0.045 Tw T* (\225\022\032\r\032\b\022\t. \211\031\024\023\031\007\025\020\t \036\021\032\ \031\033\020)Tj /T1_0 1 Tf [(. 2023;2\(12\):158\226175. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.34883/)Tj T* (PI.2023.12.2.019)Tj 0 0 0 1 k /GS1 gs 0.046 Tw [( / T)60(sypl)-16(akov)]TJ /Span<>> BDC ( )Tj EMC (K.G., Denisenko)Tj /Span<>> BDC ( )Tj EMC [(V.L., Gain Y)34.9(u.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.008 Tw T* [(E)35(xper)-37(iment)15.1(al subst)15.1(ant)-32(ia)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(biol)30(o)-16(gical p)25(r)-32(o)17(tec)-16(t)-32(ion me)-12(t)-13(hods appl)35.1(y)]TJ 0 Tw 27.286 0 Td (-)Tj 0.028 Tw -27.286 -1.25 Td [(ing for col)30(onic anast)17(omosis for)-16(med under condi)-23.9(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(l)-15.9(ap)32(ar)-32(oscopi)]TJ 0 Tw (-)Tj 0.001 Tw T* [(call)35(y assisted sur)-32(ger)-23.9(y. )]TJ /T1_3 1 Tf [(Surg)12(er)-43(y. Easter)-14(n Europe)]TJ /T1_0 1 Tf (. 2023;2\(12\):158\226175. )Tj 0.023 Tw T* [(\(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.34883/PI.2023.12.2.019)Tj 0 0 0 1 k /GS1 gs 0.219 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\024\004\036\021\t\020\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\203.\207., \204\036\007\r\036\007\036\r\026)Tj /Span<>> BDC ( )Tj EMC [(\214.\200. \217\036\031\035\034\021\026\021\t )0.5(\f\030\026\r\027\017\021\036\035\034\027\024\020\024 )]TJ 0.285 Tw -1.296 -1.25 Td [(\026\027\026\035\017\026 )0.5(\002\017\024\035\024\020\017\004\036\f\022\024\005 )0.6(\020\036\030\n\036\021\017\004\027\024\f\021\017 )0.6(\001\r\024\r )0.5(\032\036\035\031\007\022\026 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 24.783 0 Td (\022\024\001\036\022. )Tj /T1_3 1 Tf 0.012 Tc 0.456 Tw -24.783 -1.25 Td (\002\016\021\027\024\023\022\t \215\027\255\030\r\025\020\032\031\030\025\ \031\235 \020\n\020\030\027\026\022\022 \020\b\032\020\032\025\031\b\031\ \031\240\032\020\016\031\021\020\025\022\t)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.282 Tw T* [(2018;42\(20\):88\22691. / K)25.1(o)-16(che)-12(t)-10(ygov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(N.B., Med)-17(vedev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.V. R)13(esul)56.1(ts )]TJ 0.01 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve anal)35(y)-12.9(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he biol)30(o)-15.9(gical t)-32(ightness of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-37(ic sutur)-24(es )]TJ 0.189 Tw T* [(in ca)15(ts. )]TJ /T1_3 1 Tf [(N)18(e)10(ws of)]TJ /Span<>> BDC ( )Tj EMC [(the Inter)-13.9(national Academ)11(y of)]TJ /Span<>> BDC ( )Tj EMC [(A)11(g)14(rar)-36.9(ian Education. )]TJ /T1_0 1 Tf 0.023 Tw T* (2018;42\(20\):88\22691. \(in Russ.\).)Tj 0.137 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\204\024\f\024\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \204\031\021\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \206\031\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \222\024\r\030\036\n\036\027\027\t\036 )Tj 0.018 Tc 0.65 Tw -1.296 -1.25 Td (\f\023\024\f\024\002\t \027\026\035\024\032\036\027\017\016 \022\017\001\ \036\004\027\024\020\024 \001\r\026. )Tj /T1_3 1 Tf [(\001\020\r\007\025\031\027 \031\240\031\016\032\027\025\022\027.)18( )]TJ 0 Tc 0.188 Tw T* [(\215\027\030\022\006\022\025\024\n\022\027 )0.6(\025\020\r\n\022)]TJ /T1_0 1 Tf [(. )0.5(2024;2:43\22648. )0.6(/ )0.6(M)-24(osol)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 20.286 0 Td [(A.V., )0.6(Mut)17(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 5.614 0 Td (T.V., )Tj 0.094 Tw -25.9 -1.25 Td (Gunov)Tj /Span<>> BDC ( )Tj EMC [(S.V., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(oder)-15(n me)-12(t)-13(hods of)]TJ /Span<>> BDC ( )Tj EMC [(intest)-31.9(inal sutur)-37(ing. )]TJ /T1_3 1 Tf 0 Tw [(Scientif)-43(ic )]TJ 0.023 Tw T* [(revie)10(w. Medical sciences)]TJ /T1_0 1 Tf (. 2024;2:43\22648. \(in Russ.\))Tj 0.295 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(co)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(BB, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(Y, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(ight)]TJ /Span<>> BDC (-)Tj EMC [(a)-17(c)-16(t)-32(i)-16(v)-15(a)15.1(ted pho)17(t)17(oseal)-30.9(ing )]TJ 0.108 Tw -1.296 -1.25 Td [(wi)-24(t)-13(h human amnio)17.1(t)-32(ic membr)-33(ane str)-24(eng)17(t)-12.9(hens bo)-14(wel anast)17(omosis in )]TJ 0.136 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC 0.832 0 Td [(hypo)17(tensi)-15.9(ve, tr)-32.9(auma)]TJ /Span<>> BDC (-)Tj EMC [(r)-24(elev)-14.9(ant )0.5(swine )0.5(model. )]TJ /T1_3 1 Tf 18.11 0 Td [(Lasers )0.5(in )0.5(Surg)12(er)-43(y )0.5(and )]TJ 0 Tw 10.114 55 Td (Medicine)Tj /T1_0 1 Tf 0.023 Tw [(. 2022;3\(54\):407\226417. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1002/ls)26(m.23485)]TJ 0 0 0 1 k /GS1 gs 0.011 Tc 0.424 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.842 0 Td (\230\027\026\030\b\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \214\017\023\026\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \003\026\021\024\035\024\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11.1( )]TJ 0.019 Tc 0.703 Tw -1.842 -1.25 Td (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \024\002\ \024\f\027\024\r\026\027\017\036 \220\235\235\036\022\021\017\r\027\024\f\ \021\017 \023\030\017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.208 Tw T* (\027\017\016 \027\024\r\t\b \023\024\035\017\n\036\030\027\t\b \n\036\n\002\ \030\026\027 \007\035\016 \020\036\030\n\036\021\017\026\006\017\017 \035\ \017\027\017\017 \001\r\024\r )Tj 0.246 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \021\024\035\f\021\024\022\017\ \001\036\004\027\t\b \026\027\026\f\021\024\n\024\024\r. )Tj /T1_3 1 Tf (\211\027\024\023\025\022\n \204\n\024)Tj 0 Tw (-)Tj 0.01 Tc 0.37 Tw T* (\033\027\032\022\026\027\025\023\020\f\017\025\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\n\f\022\025\022\007\027\024\n\031\235 \200\022\032\r\032\b\022\022)Tj /T1_0 1 Tf [(. 2016;3:176\226180. /)10( )]TJ 0 Tc 0.301 Tw T* [(M)-24(osol)30(ov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Mut)17(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (T.V., Gunov)Tj /Span<>> BDC ( )Tj EMC [(S.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-23.9(oder)-15(n me)-12(t)-13(hods )]TJ 0.005 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(intest)-32(inal sutur)-36.9(ing. )]TJ /T1_3 1 Tf [(Scientif)-43(ic revie)10.1(w. Medical sciences)]TJ /T1_0 1 Tf (. 2024;2:43\226)Tj 0.023 Tw T* (48. \(in Russ.\).)Tj 0.007 Tc 0.349 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.824 0 Td [(\215\026\021\036\027\021 \223 2813120 C1 \217\024\f\f\017\005\f\022\026\016\ \205\036\007\036\030\026\006\017\016, \204\215\025 A61L)7.1( )]TJ 0 Tc 0.138 Tw -1.824 -1.25 Td (15/24, A61L 15/28, A61L 15/44. \216\017\030\031\030\020\017\004\036\f\022\ \026\016 \023\024\035\017\n\036\030\027\026\016 \n\036\n)Tj 0 Tw (-)Tj 0.118 Tw T* (\002\030\026\027\026 : \223 2023127789 : \026\016\r\035. 27.10.2023 : \024\ \023\031\002\035. 06.02.2024 / )Tj 0.082 Tw T* (\200.\215.)Tj /Span<>> BDC ( )Tj EMC (\206\026\r\030\017\035\033\022, \200.\202.)Tj /Span<>> BDC ( )Tj EMC (\214\017\023\026\021\024\r, \213.\222.)Tj /Span<>> BDC ( )Tj EMC [(\204\017\001\017\027\026 \017 \f\024\026\r\021. 11. P)40(a)15(tent N)-14(o. )]TJ 0.097 Tw T* [(2813120 C1 Russian F)10(eder)-33(a)15(t)-32(ion, IPC A61L 15/24, A61L 15/28, A61L )]TJ 0.099 Tw T* [(15/44. Sur)-31.9(gical pol)35(ymer membr)-33(ane : N)-14(o. 2023127789 : appl)-30.9(ica)15(t)-32(ion )]TJ 0.201 Tw T* [(27.10.2023 : publ)-31(ished 06.02.2024 / V.P.)]TJ /Span<>> BDC ( )Tj EMC [(Gavr)-36.9(il)35(yuk, V.A.)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ip)32(a)15(t)17(ov, )]TJ 0.023 Tw T* (E.S.)Tj /Span<>> BDC ( )Tj EMC [(Mishina e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al.)Tj 0.08 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\217\036\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\202., \206\030\017\r\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\222.\206. \233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\026\016\ \024\006\036\027\022\026 \n\036\b\026)Tj 0 Tw (-)Tj 0.188 Tw -1.796 -1.25 Td [(\027\017\004\036\f\022\017\b \023\030\024\004\027\024\f\021\027\t\b \f\r\ \024\005\f\021\r \023\030\036\006\017\017\024\027\027\t\b )0.5(\024\007\027\024\030\016\007\027\t\b \n\036\032)]TJ 0 Tw (-)Tj 0.073 Tw T* [(\022\017\001\036\004\027\t\b )0.5(\026\027\026\f\021\024\n\024\024\r. )]TJ /T1_3 1 Tf 10.29 0 Td [(\020\021\032\022\007\027\024\n\022\235 )0.5(\026\027\030\022\n\031-\240\022\031\f\031\b\022\007\027\024\n\022\235 )0.6(\021\027\024\023)]TJ 0 Tw (-)Tj -10.29 -1.25 Td (\025\022\n)Tj /T1_0 1 Tf 0.015 Tw [(. 2020;3\(23\):67\22672. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.29039/2070-8092-2020-23-3-67-72)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.017 Tw T* [(/ )0.5(R)13(ezanov)]TJ /Span<>> BDC ( )Tj EMC 4.268 0 Td [(P.A., )0.5(G)20(r)-36.9(i)-16(venko)]TJ /Span<>> BDC ( )Tj EMC 5.882 0 Td [(S.G. )0.5(E)35(xper)-36.9(iment)15(al )0.5(ev)-15(al)35(ua)15(t)-32(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 12.924 0 Td (mechanical )Tj 0.02 Tw -23.074 -1.25 Td [(str)-23.9(enght p)25(r)-32(oper)-22(t)-32(ies in p)25(r)-23.9(ec)-24(ise single-l)-15.9(a)15(yer)-24(ed intest)-32(inal anast)17(omosis. )]TJ /T1_3 1 Tf -0.031 Tw T* [(T)54(aur)-37(ide )0.6(Medical )0.6(and )0.6(Biological )0.6(Bulletin)]TJ /T1_0 1 Tf [(. )0.5(2020;3\(23\):67\22672. )0.6(\(in )0.5(Russ.\). )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.29039/2070-8092-2020-23-3-67-72)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.425 Tw -1.847 -1.25 Td [(1)0.5(3)0.5(.)]TJ /Span<>> BDC 1.33 0 Td ( )Tj EMC 0.511 0 Td [(\230)0.5(\r)0.5(\026)0.6(\027)0.5(\024)0.5(\r)]TJ /Span<>> BDC 3.117 0 Td ( )Tj EMC [(\222)0.5(.)0.5(\212)0.5(.)0.5(,)0.5( \222)0.5(\035)0.5(\017)0.5()0.6(\024)0.5(\r)0.5(\f)0.5(\022)0.5(\017)0.6(\005)]TJ /Span<>> BDC 8.146 0 Td ( )Tj EMC [(\206)0.5(.)0.5(\200)0.5(.)0.5(,)0.5( \231)0.5(\017)0.5(\022)0.5(\031)0.6(\027)0.5(\024)0.5(\r)0.5(\026)]TJ /Span<>> BDC 7.434 0 Td ( )Tj EMC [(\242)0.5(.)0.5(\200)0.5(.)0.5(,)0.6( \017)]TJ /Span<>> BDC 3.821 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.5(\r)0.5(\021)0.5(.)12( )]TJ 0 Tc 0.111 Tw -24.361 -1.25 Td (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \n\024\007\ \036\035\017\030\024\r\026\027\017\036 \022\024\n\023\030\036\f\f\017\024\ \027\027\024\020\024 \026\027\026\f\021\024\n\024\026 )Tj -0.043 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\007\r\031\f\021\r\024\035\034\027\024\005 \220\027\021\036\030\024\f\021\ \024\n\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\031\f\021\030\024\005\f\021\r\026 \017)]TJ /Span<>> BDC ( )Tj EMC 25.329 0 Td (\027\017\022\036)Tj 0 Tw (-)Tj -0.01 Tw -25.329 -1.25 Td (\035\017\007\026 \021\017\021\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\n\016\021\034\033 \235\024\030\n\t. )Tj /T1_3 1 Tf (\211\027\024\023\025\022\n \204\n\024\033\027\032\022\026\027\025\023\020\ \f\017\025\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\n\f\022)Tj 0 Tw (-)Tj 0.196 Tw T* [(\025\022\007\027\024\n\031\235 )0.6(\200\022\032\r\032\b\022\022)]TJ /T1_0 1 Tf [(. )0.5(2022;15\(1\):46\22657. )0.5(d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.714 0 Td (10.18499/2070-478X-)Tj -18.714 -1.25 Td (2022-15-1-46-57)Tj 0 0 0 1 k /GS1 gs 0.005 Tw [( / Iv)-14.9(anov)]TJ /Span<>> BDC ( )Tj EMC [(S.D., S)-16(l)-31(izovsk)-15.9(i\031)]TJ /Span<>> BDC ( )Tj EMC [(G.V., S)-16(hikunov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(Y.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.064 Tw T* [(E)35(xper)-37(iment)15.1(al simul)-15.9(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)25(r)-24(ession anast)17(omosis in d)-16(ouble-bar)]TJ 0 Tw 27.286 0 Td (-)Tj 0.049 Tw -27.286 -1.25 Td [(r)-24(eled enter)-32(ost)17(omy using a)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(i)-23.9(t)15(anium nick)10(el)-30.9(ide memor)-23.9(y shape dev)-16(ice. )]TJ /T1_3 1 Tf 0.115 Tw T* [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(e)-15(xper)-37(imental and clinical surg)12(er)-43(y.)]TJ /T1_0 1 Tf ( 2022;15\(1\):46\22657. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18499/2070-478X-2022-15-1-46-57)Tj 0 0 0 1 k /GS1 gs 0.052 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(eber)]TJ /Span<>> BDC ( )Tj EMC (MC, Clees)Tj /Span<>> BDC ( )Tj EMC (Z, Buck)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ser)-31.9(osa in intest)-32(inal )]TJ 0.239 Tw -1.796 -1.25 Td [(anast)17(omo)17(t)-32(ic heal)-31(ing: insights fr)-32(om in-dept)-13(h hist)17.1(ol)30(o)-16(gical anal)35(y)-12.9(sis )]TJ 0.007 Tc 0.35 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(human )0.5(and mur)-37.1(ine anast)16.9(omoses. )]TJ /T1_3 1 Tf 16.47 0 Td (BJS Open)Tj /T1_0 1 Tf [(. 2024;8\(5\):108.)7( )]TJ 0 Tc 0 Tw -16.47 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1093/bjsopen/zr)-32.9(ae108)]TJ 0 0 0 1 k /GS1 gs 0.157 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)30(ver)-23.9(d)17(y)]TJ /Span<>> BDC ( )Tj EMC [(JC, S)-24(char)-24(de)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(HM. Anast)17(omo)17(t)-32(ic leak: t)17(o)-14(w)-12(ar)-23.9(d an)]TJ /Span<>> BDC ( )Tj EMC (under)Tj 0 Tw 25.49 0 Td (-)Tj 0.312 Tw -27.286 -1.25 Td [(st)15(anding of)]TJ /Span<>> BDC ( )Tj EMC [(i)-23.9(ts r)-32(o)-16(o)17(t causes. )]TJ /T1_3 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Gastrointestinal Surg)12(er)-42.9(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021;11\(25\):2966\2262975. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-021-05048-4)Tj 0 0 0 1 k /GS1 gs 0.135 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ok)-17(afor)]TJ /Span<>> BDC ( )Tj EMC [(DK, K)-16(a)15(t)-10(y)22(al)]TJ /Span<>> BDC ( )Tj EMC [(G, K)-16(aur)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ingle-l)-15.9(a)15(yer or d)-15.9(ouble-l)-16(a)15(yer )]TJ -0.05 Tw -1.796 -1.25 Td [(intest)-31.9(inal anast)17(omosis: A)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-15.9(iew of)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized contr)-31.9(olled )]TJ 0 Tw T* [(tr)-37(ials. )]TJ /T1_3 1 Tf 2.646 0 Td (Cureus)Tj /T1_0 1 Tf 0.023 Tw [(. 2023;15\(10\):e46697. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.46697)]TJ /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.165 56.0378 Tm (70)Tj ET endstream endobj 1271 0 obj <>/Border[0 0 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[(Ef)-31(fectiv)12.1(eness of ne)11(w polymer membr)21.1(anes for intestinal anastomoses)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.134 Tw 10 0 0 10 42.5197 578.6938 Tm (\r\024\007\031\b\026 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\007\022\024\f\021\017\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (2\2263)Tj /Span<>> BDC ( )Tj EMC (\030\026\026 \023\030\036)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD [(\r\t\001\026\033\013\036\n )0.5(\027\024\030\n\026\035\034\027\024\036 )0.6(\235\017\017\024\035\024\020\017\004\036\f\022\024\036 )0.6(\007\026\r\035\036\027\017\036 )]TJ 0.024 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036 \240\025\221 \(20\22630 \n\n \030\021.\f\021\ .\). \221\026\022\032\036 \f\021\024\017\021 \024\021\n\036)Tj 0 Tw (-)Tj 0.094 Tw 0 -1.218 TD [(\021\017\021\034, )0.5(\004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.753 0 Td [(\017\f\023\024\035\034\024\r\026\027\017\017 )0.6(\030\026\030\026\002\024\021\026\027\027\t\b )0.6(\026\r\021\024\030\026)]TJ 0 Tw (-)Tj 0.026 Tw -5.753 -1.218 Td (\n\017 \215\204 \(\020\030\031\023\023\t \2231\2265\) \024\021\n\036\004\ \026\033\021\f\016 \r\t\f\024\022\017\036 \027\026\004\036\027\017\016 \ )Tj 0.326 Tw 0 -1.218 TD (\007\026\r\035\036\027\017\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \r\017\031\026\035\034\027\024 \030\036\020\017\ \f\021\030\017\030\024\r\026\035\017 )Tj 0.289 Tw 0 -1.218 TD (\023\030\017\027\026\022\017 \027\026\030\031\001\036\027\017\016 \020\036\ \030\n\036\021\017\004\027\024\f\021\017 \025\202. \200\036\030\024\016\021\ \027\024, )Tj 0.025 Tw 0 -1.218 TD (\220\021\024 \024\002\031\f\035\024\r\035\036\027\024 \023\035\024\021\027\ \024\005 \235\017\022\f\026\006\017\036\005 \215\204 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \001\r\024\r )Tj 0.23 Tw 0 -1.218 TD (\026)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td [(\f\004\036\021 )0.5(\017\b )0.6(\r\t\f\024\022\017\b )0.5(\026\007\020\036\017\r\027\t\b )0.5(\f\r\024\005\f\021\r. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.863 0 Td (\220\021\024\n )Tj 0.135 Tw -20.215 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 \017\f\f\035\036\007\024\r\026\027\ \017\016 \(\023\024\020\030\031\032\036\027\017\016 \025\202 \f)Tj /Span<>> BDC ( )Tj EMC (\215\204 )Tj 0.128 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\031\) \027\036 \024\021\n\036\004\026\035\024\f\034 \027\026\030\ \031\001\036\027\017\016 \f\024\023\030\017\022\024\f\027\024\r\036\027\017\ \016 )Tj 0.243 Tw T* (\023\024\r\036\030\b\027\024\f\021\017 \215\204 \017)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 \f\021\036\027\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 )Tj 0.058 Tw T* (\n\036\n\002\030\026\027 \020\030\031\023\023\t \223 6, \235\017\022\f\026\ \006\017\016 \022\024\021\024\030\t\b \022)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 )Tj 0.188 Tw T* [(\f\021\036\027\022\036 \002\t\035\026 \n\017\027\017\n\026\035\034\027\024\ \005 )0.5(\r\r\017\007\031 \f\035\026\002\024\r\t\030\026\032\036\027\027\t\b )]TJ 0.027 Tw T* (\026\007\020\036\017\r\027\t\b \f\r\024\005\f\021\r, \004\021\024 \027\ \026\004\017\021\036\035\034\027\024 \026\021\030\031\007\027\016\035\024\ \b\024\007 )Tj 0 Tw T* (\220\022\f\023\036\030\017\n\036\027\021\026.)Tj 0.091 Tw T* (\215\030\017 \030\026\027\032\017\030\024\r\026\027\017\017 \020\030\031\ \023\023 \017\f\f\035\036\007\024\r\026\027\017\016 \024\021 \027\026\017\ \002\024\035\034)Tj 0 Tw (-)Tj 0.209 Tw T* [(\001\036\020\024 )0.5(\027\026\004\036\027\017\016 )0.6(\007\026\r\035\036\027\017\016 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 11.948 0 Td [(\027\026\017\n\036\027\034\001\036\n\031, )0.6(\023\024\035\031\004\017\035\017 )]TJ 0.051 Tw -11.948 -1.218 Td [(\f\035\036\007\031\033\013\017\005 )0.5(\030\016\007: \223 )0.5(8 > \223 1 > )0.5(\223 4 > \223 )0.5(5 > \223 2 > \223 )0.5(3 )]TJ 0.099 Tw T* (> \223 7, \223 6. \215\030\017\n\036\004\026\021\036\035\034\027\024, \004\ \021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \2236 \017)Tj /Span<>> BDC ( )Tj EMC (\2237 )Tj 0.194 Tw T* (\027\026\017\n\036\027\034\001\017\036 \027\026\004\036\027\017\016, \022\ \024\021\024\030\t\036 \023\030\026\022\021\017\004\036\f\022\017 \027\036\ \024\021)Tj 0 Tw (-)Tj 0.349 Tw T* (\035\017\004\026\033\021\f\016. \233\021\024 \022\024\f\r\036\027\027\024\ \023\024\r\024\035\016\036\021 \f\031\007\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\027\017)Tj 0 Tw (-)Tj 0.221 Tw T* (\022\024\005 \220\235\235\036\022\021\017\r\027\024\f\021\017 \017\007\036\ \035\017\016 \007\035\016 \007\026\027\027\024\020\024 \r\026\030\017\026\ \027\021\026 )Tj 0 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\016.)Tj 0.01 Tc 0.175 Tw T* (\200\t\f\024\022\017\036 \027\026\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \2238 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n)9.9( )]TJ 0.118 Tw T* (\007\r\031\030\016\007\027\024\020\024 \001\r\026, \002\035\017\022\017\ \022)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\r\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.263 Tw T* [(\023\024\035\034\024\r\026\027\017\036\n \030\026\030\026\002\024\021\026\ \027\027\t\b \026\r\021\024\030\026\n\017 \024\002\030\026\006\024\r.)10( )]TJ 0.23 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n, \027\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\024\036 \024\002\f\031\032\007\036\027\017\036 \f\030\ \036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.543 Tw T* [(\007\017 )0.5(\017\f\f\035\036\007\024\r\026\021\036\035\036\005 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\024\007\027\024\030\016\007\027\024\020\024)10( )]TJ 0.176 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\030\016\007\027\024\020\024 \001\r\024\r [13\22616], \r)Tj /Span<>> BDC ( )Tj EMC [(\f\035\031\004\026\036 )0.5(\017\f\023\024\035\034\024\r\026)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.361 Tw T* (\027\017\016 \024\030\017\020\017\027\026\035\034\027\024\020\024 \n\036\ \021\024\007\026 \023\027\036\r\n\024\023\030\036\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.23 Tw T* [(\004\036\f\021\r\036 \f\023\024\f\024\002\026 \024\006\036\027\022\017 \020\ \036\030\n\036\021\017\004\027\024\f\021\017 \026\027\026\f\021\024\n\024\ \026)10( )]TJ 0.127 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC [(\f\004\036\021 \031\021\036\004\022\017 \r\024\007\031\b\026, \023\030\036\ \007\023\024\004\021\036\027\017\036 \f\021\024\017\021 \024\021\007\026\ \021\034)10( )]TJ 0.056 Tw T* [(\007\r\031\030\016\007\027\024\n\031 \001\r\031. \221\026\022\032\036 \253\ \026\n\036\027\017\021\034\273 \007\r\031\030\016\007\027\t\005 \001\024\ \r)10( )]TJ 0.286 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\017\021\034 \r\030\036\n\016 \024\023\036\030\026\ \006\017\017 \023\024\r\024\035\017\021 \023\030\017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.223 Tw 0 -1.218 TD (\027\017\036 \030\026\030\026\002\024\021\026\027\027\t\b \215\204, \022\ \024\021\024\030\t\036 \023\024\n\017\n\024 \026\007\020\036\017\r)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.313 Tw 0 -1.218 TD [(\027\t\b )0.5(\f\r\024\005\f\021\r )0.5(\024\002\035\026\007\026\033\021 )0.5(\036\013\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.874 0 Td [(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005)10( )]TJ 0.101 Tw -13.874 -1.218 Td (\026\022\021\017\r\027\024\f\021\034\033, \004\021\024 \023\024\r\024\035\ \017\021 \017\f\023\024\035\034\024\r\026\021\034 \017\b \017)Tj /Span<>> BDC ( )Tj EMC (\r \031\f)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.184 Tw 0 -1.218 TD (\035\024\r\017\016\b \023\036\030\017\021\024\027\017\021\026. \003\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \220\035\026\f\021\017\004\027\024\f\021\017 \215\204 \r\024\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.019 Tw 0 -1.218 TD (\n\024\032\027\024 \030\026\f\f\n\024\021\030\036\021\034 \r\026\030\017\ \026\027\021\t \017\b \027\026\035\024\032\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\027\031)10( )]TJ 0.345 Tw 0 -1.218 TD (\025\202 \r)Tj /Span<>> BDC ( )Tj EMC [(\b\024\007\036 \220\027\007\024\r\017\007\036\024\b\017\030\031\030\020\017\ \004\036\f\022\017\b \024\023\036\030\026\021\017\r\027\t\b)10( )]TJ -0.01 Tw 0 -1.218 TD (\r\n\036\001\026\021\036\035\034\f\021\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 14 0 0 14 275.0305 578.6938 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.203 Tw 10 0 0 10 274.9606 554.3378 Tm (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \025\202 \ \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \016\r\035\016\036\021\ \f\016 )Tj 0.544 Tw 0 -1.218 TD (\026\022\021\031\026\035\034\027\024\005 \023\030\024\002\035\036\n\024\005\ \026\002\007\024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\ \017\017. )Tj 0.28 Tw T* [(\217\036\031\035\034\021\026\021\t )0.6(\023\030\024\r\036\007\036\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024\r\024\035\016\033\021 )]TJ 0.066 Tw T* (\031\021\r\036\030\032\007\026\021\034, \004\021\024 \n\036\b\026\027\017\ \004\036\f\022\024\036 \031\022\030\t\021\017\036 \024\027\t \025\202 \030\ \026)Tj 0 Tw (-)Tj 0.407 Tw T* [(\030\026\002\024\021\026\027\027\t\n\017 \024\002\030\026\006\026\n\017\ )0.5(\215\204 \016\r\035\016\036\021\f\016 )0.5(\007\024\f\021\026\021\024\004\027\024 )]TJ 0.124 Tw T* (\220\235\235\036\022\021\017\r\027\t\n \n\036\021\024\007\024\n \023\030\ \024\235\017\035\026\022\021\017\022\017 \027\036\f\024\f\021\024\016\021\ \036\035\034)Tj 0 Tw (-)Tj 0.045 Tw T* (\027\024\f\021\017 \025\202. \233\021\024 \023\024\r\024\035\016\036\021\ \030\036\022\024\n\036\027\007\024\r\026\021\034 \017\b \007\035\016 \007\ \026\035\034)Tj 0 Tw (-)Tj T* (\027\036\005\001\036\020\024 \021\036\f\021\017\030\024\r\026\027\017\016\ .)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.133 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-5.9(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.8(:)]TJ /T1_4 1 Tf [( \035)14.6(\020)0.7(\016)5.1(\020)1.8(\032\027)2.3(\025)10.7(\n)9.8(\031)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.007 Tc 0.007 Tw T* [(\035)7.6(\022)0.7(\033\020)-5.2(\023)-3(\031)2.6(\021)]TJ /Span<>> BDC 3.694 0 Td ( )Tj EMC [(\211)17.3(.\003)-9.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.694 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw [( \205)1.9(\027\021)-7.8(\027)-7.9(\032)-0.6(\022\025)-3.2(\031)2.6(\021)]TJ /Span<>> BDC 17.148 0 Td ( )Tj EMC [(\220)-5.6(.\003)-9.3(.)]TJ /T1_1 1 Tf 0.018 Tc -0.018 Tw -17.148 -1.218 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw 11.349 0 Td [( \202)6.3(\r)-21.9(\030)-26.3(\032)-18.3(\t)-14.4(\021)-23.5(\006)-26.3(\027)-22.4(\021)-26.9(\020)]TJ /Span<>> BDC 4.945 0 Td ( )Tj EMC [()36(.\001.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -16.294 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw 7.694 0 Td [( \205)1.8(\027\021)-7.8(\027)-7.9(\032)-0.6(\022\025)-3.2(\031)2.6(\021)]TJ /Span<>> BDC 4.408 0 Td ( )Tj EMC [(\220)-5.6(.\003)-9.3(.)0.8(,)-7( \202)8.6(\031)-4.6(\026\020)-5.2(\032)-6.9(\031)2.6(\021)]TJ /Span<>> BDC 5.853 0 Td ( )Tj EMC [(\220)-5.6(.\003)-9.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -17.955 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf [( \035)14.6(\020)0.6(\016)5.1(\020)1.8(\032\027)2.3(\025)10.7(\n)9.8(\031)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)7.3(\003)-2.3(.)7.8(, \035)14.6(\022)7.8(\033)7.4(\020)1.8(\023)4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)7.3(\003)-2.3(.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.098 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.5(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e )0.5(s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( V)-5.5(i)2.6(c)-28.6(t)1.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-4.5(a)-4.5(z)12.9(ar)2.4(e)-2.6(n)7.5(k)12.9(o)-3.7(, )]TJ -0.006 Tc 0.006 Tw T* [(V)-11.5(ia)-11(c)-4.1(h)-4.1(e)-24(s)3.3(l)-2.7(a)-10.4(v)]TJ /Span<>> BDC 4.081 0 Td ( )Tj EMC [(A)-18.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(L)-2.9(ip)-8(a)-10.9(t)-4.6(o)-6.6(v)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -5.16 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(e)-4(v)6.6(e)-1.7(r)-35.2(i)8.4(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-12.9(o)-14(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf -0.005 Tc 0.005 Tw 9.088 0 Td [( T)44.7(a)-9.9(t)-35(y)-1.2(a)-5.8(na)]TJ /Span<>> BDC 3.339 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(K)7.3(u)-6.6(dr)-45.2(y)-1.2(a)-9.4(v)-36.5(t)-34.1(se)-9(v)5.8(a)]TJ /T1_1 1 Tf 0 Tc 0.976 Tw -13.516 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_4 1 Tf [( D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(e)-4(v)6.6(e)-1.7(r)-35.3(i)8.4(n)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(D)-2(m)5.8(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(om)4.3(ar)2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( V)-5.5(i)2.6(c)-28.6(t)1.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-4.6(a)-4.5(z)13(ar)2.4(e)-2.6(n)7.5(k)12.9(o)-3.7(, V)-5.5(i)6(a)-5(c)1.8(h)1.9(e)-18(s)9.3(l)3.3(a)-4.4(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.2(i)5.8(p)-2(a)-4.9(t)1.4(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.581 Tw T* (\214\026\026\030\036\027\022\024 \200\017\022\021\024\030 \202\027\026\021\ \024\035\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024)Tj 0 Tw (-)Tj 0.964 Tw T* [(\235\036\f\f\024\030, )0.5(\026\r\036\007\031\033\013\017\005 )0.5(\022\026\235\036\007\030\024\005 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b )]TJ 0.653 Tw T* (\002\024\035\036\027\036\005 \230\027\f\021\017\021\031\021\026 \027\036\ \023\030\036\030\t\r\027\024\020\024 \024\002\030\026\024\r\026\027\017\ \016, )Tj 0.29 Tw T* [(\030\036\022\021\024\030 \205\206\207\210\211 )0.5(\200\210 \025\206\204\211 )0.5(\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; )0.5(ORCID )]TJ 0 Tw T* (0000-0002-2069-7701.)Tj 0.03 Tc 0.702 Tw T* (\214\017\023\026\021\024\r \200\016\004\036\f\035\026\r \202\035\036\022\ \f\026\027\007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC [(\227 \007.\n.\027.,)30( )]TJ 0.676 Tw T* [(\023\030\024\235\036\f\f\024\030, \023\030\024\235\036\f\f\024\030 \022\026\ \235\036\007\030\t \024\023\036\030\026\021\017\r\027\024\005)30( )]TJ 0.767 Tw T* (\b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\023\024\020\030\026\235\017\004\036\f\022\024\005 \026\027\026\021\ \024\n\017\017, \026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 1.138 Tw T* [(\r\036\007\031\033\013\017\005 \035\026\002\024\030\026\021\024\030\017\036\ \005 \220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\005)30( )]TJ 0.621 Tw T* [(\b\017\030\031\030\020\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.372 0 Td [(\024\027\022\024\035\024\020\017\017 )0.5(\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.432 Tw -6.372 -1.218 Td [(\f\022\024\020\024 \017\027\f\021\017\021\031\021\026 \220\022\f\023\036\ \030\017\n\036\027\021\026\035\034\027\024\005 \n\036\007\017\006\017\027\ \t,)30( )]TJ 0.109 Tw T* (\023\030\024\030\036\022\021\024\030 \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\031\004\027\024\005 \030\026\002\024\021\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\027\024\r\026\006\017\024\027\027\024\n\031)30( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( \206\027\016\r\f\017\023\020\023\013 \033\031\033\020\032\025\031\b\031\ \024\032\020\021\025\027\025\022\t \016\025\020\007\027\025\022\235 \030\ \020\021\f\027\025\022\t \021\031\016\030)0.5(\r\200\020 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\033\025\027\021\026\031\033\032\027\024\024\022\022 \n\022\213\027\007\025\ \013\200 \020\025\020\024\023\031\026\031\016\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 3.334 0 Td [( R)2.8(e)-22(s)6.7(u)-1.5(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-6.3(i)5(r)-33.4(w)-26.7(i)6.6(s)0.5(e c)2.8(o)-4(m)-0.9(p)-6.4(a)-4.1(r)-39(i)6.6(s)0.5(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-6.2(i)4.9(r p)-2.8(r)-2(e)-22(s)-10.5(s)6.7(u)1.6(r)-2(e v)6.4(a)-4.5(lu)-3.2(e)-22(s d)0.8(u)1.7(r)-39(i)3.9(n)-0.6(g p)-3.7(n)-2.4(e)-4.2(u)0.6(m)-5.3(o)-5.3(p)-2.8(r)-2(e)-21.9(s)-10.5(s)-12.5(i)-1.4(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(i)4(n)-0.6(t)-1.6(e)-22(s)-14.8(t)-29.1(i)3.9(na)-4.5(l a)-5.1(n)0.5(a)-7.2(s)-14.8(t)-3(o)-4(m)-5.3(o)-1.1(s)0.5(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 99.4626 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 212.8484 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 326.2343 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 703.7117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 692.2505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 680.7892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 669.3279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 657.8666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.4053 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 646.4053 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.944 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 634.944 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 623.4828 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 99.4626 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 439.6201 623.4828 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 58.9604 706.5463 Tm (\027\006\210\212\212\004)Tj 7.838 0 Td (\2362)Tj 7.087 0 Td (\2363)Tj 7.087 0 Td (\2364)Tj 7.087 0 Td (\2365)Tj 7.087 0 Td (\2366)Tj 6.97 0 Td (\236 7)Tj 7.087 0 Td (\236 8)Tj /T1_1 1 Tf -51.91 -1.433 Td (\223 1)Tj 9.683 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 6.337 0 Td (0,001*)Tj 7.087 0 Td (0,003*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 2)Tj 16.77 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 6.337 0 Td (0,001*)Tj 7.087 0 Td (0,002*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 3)Tj 23.856 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 6.337 0 Td (0,024*)Tj 7.337 0 Td (0,054)Tj 7.587 0 Td (1,0)Tj -52.203 -1.433 Td (\223 4)Tj 30.943 0 Td (1,0)Tj 6.337 0 Td (0,001*)Tj 7.087 0 Td (0,003*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 5)Tj 37.28 0 Td (0,002*)Tj 7.087 0 Td (0,005*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 6)Tj 45.116 0 Td (1,0)Tj 6.337 0 Td (0,002*)Tj -51.453 -1.433 Td (\223 7)Tj 51.453 0 Td (0,004*)Tj /T1_4 1 Tf 7 0 0 7 42.5197 611.998 Tm [(\004\032\022\026\027\007\020\025\022\027: \207\025\020\n\031\026 \253*\273\ \031\023)16.3(\026\027\007\027\025\013 \024\023\020)49(\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\026\013\027 \ \016\025\020\007\027\025\022\t \(\033\032\022 p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8518 56.0378 Tm (69)Tj ET endstream endobj 1262 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (\()Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf 0.182 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (30\) \r)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\t\b \020\030\031\ \023\023\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\027\t\n )Tj 0.124 Tw 0 -1.218 TD (\024\021 \027\024\030\n\026\035\034\027\024\020\024 \030\026\f\023\030\036\ \007\036\035\036\027\017\036\n \r\t\002\024\030\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036)Tj 0 Tw (-)Tj 0.032 Tw T* (\030\017\033 \231\026\023\017\030\024\226\211\017\035\022\026 \f\030\026\ \r\027\036\027\017\036 \027\036\f\022\024\035\034\022\017\b \020\030\031\ \023\023 \007\035\016 )Tj -0.012 Tw T* (\024\006\036\027\022\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \ \027\026\004\017\n\t\b \030\026\035\017\004\017\005 \023\030\024\r\024\ \007\017\035\017 )Tj 0.28 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \027\036\023\026\030\026\ \n\036\021\030\017\004\036\f\022\024\020\024 H-\022\030\017\021\036\030\017\ \016 )Tj 0.797 Tw T* [(\025\030\026\f\022\036\035\026\226\211\024\035\035\017\f\026. )0.6(\215\024\023\026\030\027\t\036 )0.5(\f\030\026\r\027\036\027\017\016 )0.6(\(post-)]TJ 0.165 Tw 0 -1.218 TD [(ho)-16(c \f\030\026\r\027\036\027\017\016\), \r\t\023\024\035\027\036\027\t \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 U-\022\030\017\021\036\030\017\016 )Tj 0.681 Tw 0 -1.218 TD [(\204\026\027\027\026\226\211\017\021\027\017. )0.6(\025\030\017\021\017\004\036\f\022\017\005 )0.6(\031\030\024\r\036\027\034 )0.5(\027\026\004\017\n\024\f\021\017 )]TJ 0.169 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\030\022\036 \f\021\026\021\017\f\021\017\004\036\f\022\ \017\b \020\017\023\024\021\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f)Tj 0 Tw (-)Tj T* (\f\035\036\007\024\r\026\027\017\017 \023\030\017\027\017\n\026\035\017 \ \030\026\r\027\t\n 0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 578.6938 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.131 Tw 10 0 0 10 70.8661 554.3378 Tm (\222\024\020\035\026\f\027\024 \023\024\035\031\004\036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \017\f\f\035\036\007\024\r\026\027\017\016 \007\026\027\027\ \t\n, )Tj 0.445 Tw T* (\017\n\036\033\021\f\016 \f\021\026\021\017\f\021\017\004\036\f\022\017 \ \027\026\004\017\n\t\036 \024\021\035\017\004\017\016 \n\036\032\007\031\ )Tj -0.006 Tw T* (\020\030\031\023\023\026\n\017 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.006 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,00002\). \203\026\017\002\024\035\034\001\036\036 \027\026\004\036\027\ \017\036 \007\026\r\035\036)Tj 0 Tw (-)Tj -0.028 Tw T* (\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\027\036\r\n\024\023\030\036\f\f\017\017 \f\235\024\030\n\017\030\024\ \r\026\027\027\t\b \025\202 \r\t\016\r\035\036)Tj 0 Tw (-)Tj -0.005 Tw T* (\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \2238 \(\007\r\031\030\016\007\027\t\005 \025\202\ \) \(85 [79,5; 87]\), \f)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj -0.051 Tw T* (\027\017\006\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (0,5 \n\n \030\021.\f\021. \024\021\n\036\004\036\027\t \027\026\004\036\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \2231 )Tj 0.063 Tw T* (\(\215\204 \002\036 \r\027\036\f\036\027\017\016 \026\027\021\017\002\026\ \022\021\036\030\017\026\035\034\027\t\b \f\030\036\007\f\021\r\) \(84,5\ )Tj 0.24 Tw T* ([83; 85]\) \017)Tj /Span<>> BDC ( )Tj EMC (\2234 \(\215\204 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\f\036\027\017\036\n \214\036\r\024\235\035\024\022\f\026\006\017\ \027\026 )Tj 0.185 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\005 \215\200\215 \017)Tj /Span<>> BDC ( )Tj EMC (\247\024\020\036\022\f\024\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\005 \202\035\034\020\017\027\026\021\026 \027\026\021\030\017\ \016\) )Tj 0.133 Tw T* (\(84,5 [83,25; 86]\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\). \203\024 \027\026\004\036\027\017\016 \020\030\031\023\023\t \2238\ )Tj 0.602 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \023\ \030\036\024\002\035\026\007\026\036\021 \021\024\035\034\022\024 \027\026\ \007 )Tj 0.181 Tw 23.244 29.227 Td (\027\026\004\036\027\017\016\n\017 \020\030\031\023\023 \223 6 \(62 [60\ ,5; 63]\) \017)Tj /Span<>> BDC ( )Tj EMC (\223 7 \(63,5 )Tj 0.075 Tw 0 -1.218 TD ([59,5; 65,75]\) \027\026)Tj /Span<>> BDC ( )Tj EMC (23 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\) \017)Tj /Span<>> BDC ( )Tj EMC (21,5 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\) \n\n )Tj 0 Tw 0 -1.218 TD (\030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021., \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.268 Tw 0 -1.218 TD (\215\030\017 \f\030\026\r\027\036\027\017\017 \007\026\027\027\t\b \024\002\ \027\026\030\031\032\036\027\t \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )Tj 0.006 Tw 0 -1.218 TD (\027\026\004\017\n\t\036 \024\021\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\): \027\026\004\036\027\017\016 \007\026\r)Tj 0 Tw (-)Tj -0.032 Tw 0 -1.218 TD (\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\027\036\r\n\024\023\030\036\f\f\017\017 \025\202 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \223 6 \(\n\036\n\002\030\026\027\026 )Tj 0.001 Tw 0 -1.218 TD (\017\023\035\026\027\021\017\030\031\036\n\026\016\) \(62 [60,5; 63]\) \n\ \036\027\034\001\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (22,5 \n\n \030\021. )Tj -0.029 Tw 0 -1.218 TD (\f\021., \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \223 1 \(84,5 [83;85]\) \017)Tj /Span<>> BDC ( )Tj EMC (\223 4 \(84,5 [83,25; )Tj 0.027 Tw T* (86]\), \027\026)Tj /Span<>> BDC ( )Tj EMC (22)Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023\023\t \223 5 \(84 [82; 86,75]\), \027\026)Tj /Span<>> BDC ( )Tj EMC (21,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.078 Tw T* (\020\030\031\023\023\t \223 2 \(83,5 [83; 86,75]\), \027\026)Tj /Span<>> BDC ( )Tj EMC (21)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \2233 )Tj 0 Tw T* (\(83 [81,25; 85,25]\).)Tj 0.091 Tw T* (\200 \020\030\031\023\023\036 \2237 \(\017\f\023\024\035\034\024\r\026\027\ \017\036 \024\007\027\024\030\016\007\027\024\020\024 \025\202\) \(63,5 \ )Tj 0.472 Tw T* ([59,5; 65,75]\) \027\026\004\036\027\017\016 \024\006\036\027\017\r\026\ \036\n\024\020\024 \023\026\030\026\n\036\021\030\026 )Tj 0.182 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \n\ \036\027\034\001\036 \027\026\004\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b )Tj 0.066 Tw T* (\2231 \(84,5 [83; 85]\) \017)Tj /Span<>> BDC ( )Tj EMC (\2234 \(84,5 [83,25; 86]\) \(\027\026 21 \n\n )Tj 0.023 Tw T* (\030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021.\), \2232 \(83,5 [83; 86,75]\) \(\027\026 20 \n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021.\), \017)Tj /Span<>> BDC ( )Tj EMC (\2235 )Tj 0 Tw T* (\(84 [82; 86,75]\) \(\027\026 20,5 \n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021.\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.254 Tw 10 0 0 10 303.3071 469.0918 Tm (\215\030\017 \026\027\026\035\017\036 \007\026\027\027\t\b \023\027\036\ \r\n\024\023\030\036\f\f\017\017 \025\202 \r\t\016\r\035\036\027\024, )Tj 0.27 Tw T* (\004\021\024 \r\024 \r\f\036\b \020\030\031\023\023\026\b \017\f\f\035\036\ \007\024\r\026\027\017\016, \027\036\026\r\017\f\017\n\024 \024\021 )Tj 0.201 Tw T* (\n\036\021\024\007\017\022\017 \027\026\035\024\032\036\027\017\016 \025\ \202 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\026 \030\016\007\024\r \001\r\024\r, )Tj 0.47 Tw T* [(\020\036\030\n\036\021\017\004\027\024\f\021\034 )0.6(\027\026\030\031\001\026\035\026\f\034 )0.6(\(\023\024\016\r\035\036\027\017\036 )0.5(\023\031\t\030\034\022\024\r )]TJ ET q 70.866 306.667 113.386 111.439 re W n q /GS0 gs 113.385838 0 0 111.4640488 70.8661352 306.6414348 cm /Im0 Do Q Q q 184.252 306.667 113.386 108.409 re W n q /GS0 gs 113.385838 0 0 108.5813585 184.2519593 306.4946953 cm /Im1 Do Q Q q 297.638 306.667 113.386 110.356 re W n q /GS0 gs 113.385838 0 0 110.5031414 297.6377756 306.5204051 cm /Im2 Do Q Q q 411.024 306.667 113.386 111.439 re W n q /GS0 gs 113.385838 0 0 111.4640488 411.0236225 306.6414348 cm /Im3 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.025 Tw 9 0 0 9 70.8661 295.8671 Tm [(\022\t\217\210\b\002\220 )0.5(1.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\205\200\027\026\020 )0.5(\021\013\033\031\f\025\027\025\022\t )0.5(\031\033\027\032\020\023\022\021\025\013\200 )0.6(\021\026\027\213\020\023\027\f\017\024\023\021 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 25.929 0 Td [(\022\024\033\031\f\017\016\031\021\020\025\022\027\026 )0.5(\031\240\032\020\016\006\031\021 \004\215: )0.5(\003)]TJ /Span<>> BDC ( )Tj EMC 13.499 0 Td [(\227 \r\007\020\024\023\031\n )0.5(\023\031\025\n\031\235 )0.5(\n\022\213\n\022 )]TJ 0.014 Tw -39.428 -1.2 Td [(\033\031\030\b\031\023\031\021\f\027\025 )0.5(\030\f\t \026\031\030\027\f\022\032\031\021\020\025\022\t )0.6(\023\032\020\021\026\013 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\025\020\f\031\255\027\025\022\t )0.6(\004\215; \221)]TJ /Span<>> BDC ( )Tj EMC 25.612 0 Td [(\227 \021\013\033\031\f\025\027\025\031 )0.5(\026\031\030\027\f\022\032\031\021\020\025\022\027 \023\032\020\021\026\013\ \r\007\020\024\023\n\020 \n\022\213\n\022; )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 23.782 0 Td (\227 )Tj 0 Tw -49.394 -1.2 Td (\025\020\f\031\255\027\025 \031\030\025\031\032\t\030\025\013\235 \020\025\ \020\024\023\031\026\031\016; \216)Tj /Span<>> BDC ( )Tj EMC (\227 \020\025\020\024\023\031\026\031\016 \r\n\032\013\023 \004\215)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.006 Tw 0 -1.2 TD [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC [(scheme for per)-34(for)-13.9(ming surgical inter)-41.9(v)12.9(entions using PM sam)16(ples: A)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC (section of)Tj /Span<>> BDC ( )Tj EMC [(the intestine is p)46(repared to)]TJ /Span<>> BDC ( )Tj EMC (simu)Tj 0 Tw (-)Tj 0.01 Tw T* [(late injur)-42.9(y and ov)13(erlap PM; )0.5(\221)]TJ /Span<>> BDC ( )Tj EMC [(\227 simulation )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(intestinal )0.5(tube site injur)-43(y )0.5(w)13(as per)-34(for)-14(med; B)]TJ /Span<>> BDC ( )Tj EMC [(\227 sing)13(le-row anastomosis; \216)]TJ /Span<>> BDC ( )Tj EMC (\227 anas)Tj 0 Tw (-)Tj T* [(tomosis cov)13.1(ered with PM)]TJ ET q /GS0 gs 344.6119112 0 0 130.3093856 70.8661194 101.0538041 cm /Im4 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \033\025\027\021\026\031\033\032\027\ \024\024\022\022 \n\022\213\027\007\025\013\200 \020\025\020\024\023\031\ \026\031\016\031\021 \021)Tj /Span<>> BDC ( )Tj EMC [(\022\024)0.5(\024\f\027\030\r\027\026\013\200 \b\032\r\033\033\020\200, \026\026 \032\ \023. \024\023.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(esults of)]TJ /Span<>> BDC ( )Tj EMC [(pneumop)46.1(ression of)]TJ /Span<>> BDC ( )Tj EMC (intestinal anastomoses, mm Hg)Tj ET 1 0.68 0 0.12 k /GS0 gs 157.661 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 167.2109 315.4346 Tm (A)Tj ET 1 0.68 0 0.12 k 271.457 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 281.0117 315.4346 Tm (\224)Tj ET 1 0.68 0 0.12 k 385.929 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 395.4786 315.4346 Tm (\026)Tj ET 1 0.68 0 0.12 k 497.906 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 508.0544 315.4346 Tm (\027)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (68)Tj ET endstream endobj 1263 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1A"2Qq#a $%&'()*3456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz 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Tw 0 -1.218 TD (\n\036\027\036\027\017\016 \024\002\030\026\006\024\r \023\024\035\017\n\ \036\030\027\t\b \n\036\n\002\030\026\027, \030\026\030\026\002\024\021\ \026\027)Tj 0 Tw (-)Tj 0.058 Tw T* (\027\t\b \007\035\016 \023\030\024\235\017\035\026\022\021\017\022\017 \027\ \036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 \022\017\001\036\ \004\027\t\b )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 420.3799 Tm [(\207)21(\026)45(\024\034\033\031\026)-10(\r\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.008 Tw 10 0 0 10 42.5197 396.0239 Tm (\212\017\026\005\027 \017\f\f\035\036\007\024\r\026\027\017\016: \220\022\ \f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \024\007\027\024\ \006\036\027\021)Tj 0 Tw (-)Tj -0.007 Tw T* (\030\024\r\024\036 \f\030\026\r\027\017\021\036\035\034\027\024\036 \023\ \030\024\f\023\036\022\021\017\r\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\t\n \024\f\035\036)Tj 0 Tw (-)Tj 0.081 Tw T* (\023\035\036\027\017\036\n. \222\030\024\022\017 \017\f\f\035\036\007\024\ \r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 1 \n\036\f\016\006. \025\024\027\036\004\027\026\016 )Tj 0.207 Tw T* (\021\024\004\022\026 \017\f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC 8.92 0 Td (\227 \031\030\024\r\036\027\034 \r\027\031\021\030\017\023\030\024\f\r\036\ \021\027\024\020\024 )Tj 0 Tw -8.92 -1.218 Td (\007\026\r\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\021\036\004\036\027\017\017 \r\024\007\031\b\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026\f\021\024\n\024\026.)Tj 0.176 Tw T* (\200 \022\026\004\036\f\021\r\036 \n\026\021\036\030\017\026\035\024\r \017\ \f\f\035\036\007\024\r\026\027\017\016 \017\f\023\024\035\034\024\r\026\ \035\017 )Tj 0.204 Tw T* [(\024\002\030\026\006\t \n\027\024\020\024\f\035\024\005\027\t\b )0.5(\023\024\035\017\n\036\030\027\t\b \n\036\n\002\030\026\027 \(\215\204\)\ , )]TJ 0.061 Tw T* (\030\026\030\026\002\024\021\026\027\027\t\b \022\024\035\035\036\022\021\ \017\r\024\n \026\r\021\024\030\024\r \(\020\030\031\023\023\t \2231\226\ 5\) )Tj 0.149 Tw T* ([11], \026)Tj /Span<>> BDC ( )Tj EMC (\r \022\026\004\036\f\021\r\036 \020\030\031\023\023\t \f\030\026\r\027\036\ \027\017\016, \017\f\023\024\035\034\031\036\n\t\036 )Tj 0.214 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ \017\007\036\035\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\n\002\030\026\027\026 \017\n)Tj 0 Tw (-)Tj T* (\023\035\026\027\021\017\030\031\036\n\026\016 \002\017\024\023\024\035\017\ \n\036\030\027\026\016 \(\020\030\031\023\023\026 \2236\) \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj -0.026 Tw T* [(\210\f\024\002\036\027\027\024\f\021\034\033 )0.6(\215\204 )0.5(\016\r\035\016\036\021\f\016 )0.5(\017\b )0.5(\021\030\036\b\f\035\024\005\027\024\036 )0.6(\f\021\030\024\036\027\017\036: )]TJ 0.161 Tw T* (\023\036\030\r\t\005 \f\035\024\005, \024\002\030\026\013\036\027\027\t\005\ \022)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, \r\t)Tj 0 Tw (-)Tj 0.032 Tw T* (\023\024\035\027\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\030\017\036\r\024\005 \f\024\035\017 \022\026\030\002\024\022\ \f\017\n\036\021\017\035\006\036\035\035\033\035\024\t )Tj 0.211 Tw T* (\(Na-\025\204\037\), \023\030\036\023\016\021\f\021\r\031\036\021 \030\026\ \r\017\021\017\033 \f\023\026\036\004\027\t\b \f\030\026\013\036)Tj 0 Tw (-)Tj -0.001 Tw T* (\027\017\005, \r\021\024\030\024\005 \f\035\024\005 \r\t\023\024\035\027\ \036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\035\036\027\027\024 \002\017\024\007\036\020\030\026\007\017)Tj 0 Tw (-)Tj 0.161 Tw T* (\030\031\036\n\024\020\024 \n\026\021\036\030\017\026\035\026 \(\202\035\ \034\020\017\027\026\021 \027\026\021\030\017\016\), \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\036\021 )Tj 0.143 Tw T* (\235\024\030\n\024\024\002\030\026\031\033\013\031\033 \004\026\f\021\034\ \215\204, \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\017\005 \f\035\024\005, \023\030\017\035\036)Tj 0 Tw (-)Tj 0.025 Tw T* (\020\026\033\013\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026\f\021\024\n\024\026, \r\t\023\024\035\027\036\ \027 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\024\030\026\f\021\r\024)Tj 0 Tw (-)Tj 0.259 Tw T* (\030\017\n\024\020\024 \023\024\035\017\n\036\030\026)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\035\017\r\017\027\017\035\023\017\030\030\024\035\017\007\024\ \027 \(\215\200\215\), )Tj 0.298 Tw T* (\024\002\031\f\035\026\r\035\017\r\026\036\021 \235\017\022\f\026\006\017\ \033 \215\204 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \r\t\030\026\032\036\027\027\024\005 )Tj 0 Tw T* (\026\007\020\036\017\r\027\024\005 \f\023\024\f\024\002\027\024\f\021\017\ .)Tj 0.11 Tw T* (\200 \022\026\004\036\f\021\r\036 \024\002\255\036\022\021\026 \017\f\f\035\ \036\007\024\r\026\027\017\016 \002\t\035\017 \017\f\023\024\035\034\024\ \r\026)Tj 0 Tw (-)Tj 0.008 Tw T* (\027\t \031\004\026\f\021\022\017 \021\024\027\022\024\005 \022\017\001\022\ \017 \007\035\017\027\024\005 7 \f\n, \001\017\030\017\027\024\005 2 \f\n\ , )Tj 0.171 Tw T* (\017\255\016\021\t\036 \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017 \021\030\031\023\024\r \035\017\006 \n\031\032\f\022\ \024\020\024 \023\024\035\026, \031\n\036\030)Tj 0 Tw (-)Tj 0.066 Tw T* (\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \024\021 30 \007\024)Tj /Span<>> BDC ( )Tj EMC (45 \035\036\021, \027\036 \017\n\036\033\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n)Tj 0 Tw (-)Tj 0.194 Tw T* (\027\036\036 \f\017\f\021\036\n\027\t\b \026\002\024\035\036\r\026\027\ \017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \026\002\024\035\036\r\026\027\017\005 )Tj 0.638 Tw 23.244 43.841 Td (\024\030\020\026\027\024\r \032\036\035\031\007\024\004\027\024-\022\017\ \001\036\004\027\024\020\024 \021\030\026\022\021\026 \(\023\030\024\021\ \024\022\024\035 )Tj 0.083 Tw T* (\217\233\025 \223 2 \024\021 29 \n\026\016 2025 \020.\). \003\026\002\024\ \030 \n\026\021\036\030\017\026\035\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.308 Tw T* (\032\036 \017\f\f\035\036\007\024\r\026\027\017\016 \024\f\031\013\036\f\ \021\r\035\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b )Tj 0.024 Tw T* (\f\031\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \027\026\f\021\031\023\035\036\027\017\016 \f\n\ \036\030\021\017. \211\004\026\f\021\022\017 \021\024\027\022\024\005 )Tj 0.088 Tw T* (\022\017\001\022\017 \030\026\f\f\036\022\026\035\017 \023\024\023\036\030\ \036\004\027\024, \026\021\036\n \r\024\f\f\021\026\027\026\r\035\017\r\ \026\035\017 )Tj 0.09 Tw T* [(\027\036\023\030\036\030\t\r\027\024\f\021\034 \023\031\021\036\n \027\026\ \035\024\032\036\027\017\016 )0.5(\022\017\001\036\004\027\024\020\024 \026\027\026\f\021\024)]TJ 0 Tw (-)Tj 0.309 Tw T* [(\n\024\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 4.045 0 Td [(\021\017\023\031 )0.6(\253\022\024\027\036\006-\r-\022\024\027\036\006\273, )0.6(\022\024\021\024\030\t\036 )0.5(\031\022\030\t\r\026\035\017 )]TJ 0.112 Tw -4.045 -1.218 Td (\017\f\f\035\036\007\031\036\n\t\n\017 \215\204 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\). \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\036 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.139 Tw T* (\007\024\r\026\027\017\016 \r\t\023\024\035\027\036\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (10 \026\027\026\f\021\024\n\024\024\r \026\021\030\026\r\n\026\021\017\004\ )Tj 0 Tw (-)Tj 0.027 Tw T* (\027\024\005 \027\017\021\034\033 \(\215\024\035\017\020\035\026\022\021\ \017\027 3/0\). \221\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.244 Tw T* (\r\022\035\033\004\017\035\017 \036\013\036 \007\r\036 \020\030\031\023\023\ \t \002\036 \017\f\023\024\035\034\024\r\026\027\017\016 \215\204: )Tj 0.204 Tw T* (\020\030\031\023\023\026 \2237)Tj /Span<>> BDC ( )Tj EMC (\227 \024\007\027\024\030\016\007\027\t\005 \027\036\023\030\036\030\t\r\ \027\t\005 \024\002\r\017\r\027\024\005 )Tj 0.004 Tw T* (\026\027\026\f\021\024\n\024 \004\036\030\036 \r\f\036 \f\035\024\017 \ \022\017\001\036\004\027\024\005 \f\021\036\027\022\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026 )Tj 0.131 Tw T* (\223 8)Tj /Span<>> BDC ( )Tj EMC (\227 \007\r\031\030\016\007\027\t\005 \026\027\026\f\021\024\n\024, \023\ \036\030\r\t\005 \030\016\007 \022\024\021\024\030\024\020\024 )Tj 0.048 Tw T* (\007\024\023\024\035\027\036\027 \r\021\024\030\t\n \030\016\007\024\n \031\ \035\024\r\t\b \f\036\030\024\027\024-\n\t\001\036\004\027\t\b )Tj -0.018 Tw T* [(\001\r\024\r. \215\024\f\035\036 \235\024\030\n\017\030\024\r\026\027\017\ \016 \026\027\026\f\021\024\n\024\026 )0.5(\017\f\f\035\036\007\031\036\n\t\005 )]TJ 0.078 Tw T* [(\235\030\026\020\n\036\027\021 )0.5(\021\024\027\022\024\005 \022\017\001\022\017 )0.5(\023\024\n\036\013\026\035\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 16.127 0 Td (\007\027\024 \022\024\027\021\036\005\027\036)Tj 0 Tw (-)Tj 0.059 Tw -16.127 -1.218 Td (\030\026, \026\023\024\035\027\036\027\027\024\020\024 \r\024\007\024\005\ , \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027 \023\030\024\017\r\024)Tj 0 Tw (-)Tj 0.296 Tw T* (\007\017\035\f\016 \023\030\024\022\024\035 \017\027\255\036\022\006\017\ \024\027\027\024\005 \017\020\035\024\005, \023\024\007\022\035\033\004\036\ \027\027\024\005 )Tj 0.151 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\024\036\007\017\027\017\021\036\035\034\027\024\005 \021\030\031\002\022\ \036 \026\r\021\024\n\026\021\017\004\036\f\022\024\020\024 \021\024\027\ \024\n\036\021)Tj /Span<>> BDC (-)Tj EMC 0.08 Tw T* (\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\017\f\021\036\n\t \007\035\016 \r\027\031\021\ \030\017\r\036\027\027\t\b \r\035\017\r\026\027\017\005. )Tj 0.136 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\031\f\022\036 \021\024\027\024\n\036\021\030\026 \r\024\007\031\ \b \026\023\024\035\027\016\035 \024\023\017\f\026\027\027\031\033 )Tj 0.099 Tw T* [(\f\017\f\021\036\n\031 [12]. \215\024\022\026\026\021\036\035\034 )0.5(\n\026\022\f\017\n\026\035\034\027\024 \007\024\f\021\017\020\027\031\021\ \024\020\024 )]TJ 0.07 Tw T* (\007\026\r\035\036\027\017\016 \(\n\n \030\021. \f\021.\) \n\026\027\024\ \n\036\021\030 \030\036\020\017\f\021\030\017\030\024\r\026\035 \026\r\021\ \024)Tj 0 Tw (-)Tj 0.216 Tw T* [(\n\026\021\017\004\036\f\022\017. \212\035\016 \023\024\r\t\001\036\027\017\ \016 )0.5(\021\024\004\027\024\f\021\017 \017\f\f\035\036\007\024\r\026\027\017\016\ )]TJ 0.154 Tw T* (\023\030\024\r\024\007\017\035\017 \r\017\007\036\024\235\017\022\f\026\006\ \017\033 \022\026\032\007\024\020\024 \220\021\026\023\026 \017\f\f\035\036\ \007\024)Tj 0 Tw (-)Tj 0.146 Tw T* (\r\026\027\017\016, \021\026\022\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \017\f\f\035\036\007\024\r\026\027\017\ \016 \017\f\023\024\035)Tj 0 Tw (-)Tj 0.224 Tw T* (\027\017\021\036\035\036\005 \027\036 \017\027\235\024\030\n\017\030\024\ \r\026\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\007\035\036\032\027\024\f\021\017 \024\002)Tj 0 Tw (-)Tj 0.017 Tw T* (\030\026\006\026 \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\005 \020\030\031\023\023\036 \017\f\ \f\035\036\007\024\r\026\027\017\016, \001\017\235\030\031\016 \017\b )Tj 0 Tw T* (\027\026\017\n\036\027\024\r\026\027\017\016.)Tj /T1_4 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_2 1 Tf 0.146 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\031\033 )0.5(\024\002\030\026\002\024\021\022\031 \023\024\035\031\004\036\027\027\t\b\ \007\026\027\027\t\b \023\030\024)]TJ 0 Tw (-)Tj 0.107 Tw T* [(\r\024\007\017\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.133 0 Td [(\023\030\024\020\030\026\n\n\036 )0.5(S)15(t)15(a)15(t)-32(ist)-31.9(ica )0.5(v. )0.5(13.0 )0.5(\(TIBC)13(O, )0.5(\222\231\202\). )]TJ 0.213 Tw -4.133 -1.218 Td (\203\036\023\030\036\030\t\r\027\t\036 \007\026\027\027\t\036 \023\030\036\ \007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \n\036\007\017\026)Tj 0 Tw (-)Tj 0.088 Tw T* (\027\t, 25 \017)Tj /Span<>> BDC ( )Tj EMC [(75 \023\030\024\006\036\027\021\017\035\036\005 )0.5(\(\204\036 [25; 75]\). \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.038 Tw T* (\027\017\017 \023\024\035\031\004\036\027\027\t\b \027\026\004\036\027\017\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\005 \r\t\002\024\030\022\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \205\031\024\023\020\021 \022\024\024\f\027\030\r\027\026\013\200 \033\031\ \f\022\026\027\032\025\013\200 \026\027\026\240\032\020\025 \021)Tj /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\020\200 \022\024\024\f\027\030)0.5(\031\021\020\025\022\t, \026\b/\024\026)]TJ 5.247 0 0 5.247 357.6124 733.48 Tm (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 9 0 0 9 42.5197 719.683 Tm [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( C)1.2(o)-4(m)-1(p)-9.1(o)-1(s)-12.5(i)-3.4(t)-29.1(i)-1.4(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e s)-14.8(t)-1.1(u)-5.9(d)-3(i)-1.4(e)-12.9(d p)-9.1(o)-5.3(l)6.6(y)-4.8(m)-5.3(e)-6(r m)-5.2(e)-7(m)2(b)-3.5(r)3.3(a)-5.1(n)-2.4(e)-22(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y g)-1.4(r)-2(o)-3.4(u)-2.3(p)1.8(s)-23.3(, m)-1(g)-9.2(/)65.8(c)-6.6(m)]TJ 5.247 0 0 5.247 340.7453 722.68 Tm (2)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 73.9508 715.181 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 73.9508 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 198.6752 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 198.6752 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 715.181 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 73.9508 703.7117 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 73.9508 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.6752 703.7117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 198.6752 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 703.7117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 397.1004 703.7117 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 73.9508 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.4252 682.6505 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 397.1004 682.6505 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 661.5892 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 73.9508 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 198.4252 661.5892 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 661.5892 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 397.1004 661.5892 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 630.9279 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 73.9508 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 198.4252 630.9279 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 630.9279 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 397.1004 630.9279 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 600.2666 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 73.9508 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 198.4252 600.2666 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 600.2666 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 397.1004 600.2666 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 569.6053 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 42.7697 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 73.9508 569.6053 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 73.9508 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.6752 569.6053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 198.6752 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 569.6053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 397.1004 569.6053 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 496.313 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 548.5441 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 73.9508 548.5441 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 198.6752 548.5441 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 548.5441 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 397.1004 548.5441 cm 0 0 m 99.463 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 46.2045 706.5463 Tm (\027\006\210\212\212\004)Tj 7.894 0 Td (\200\006\002\t\213\002\240\t\003\r\f\001)Tj 15.948 0 Td (1 \217\f\002\005)Tj 12.402 0 Td (2 \217\f\002\005)Tj 12.402 0 Td (3 \217\f\002\005)Tj /T1_2 1 Tf -47.376 -1.433 Td (1)Tj 3.1 0 Td (\214\026\002\024\030\026\021\024\030\017\016 \220\022\f\023\036\030\017\n\ \036\027\021\026\035\034\027\024\005 )Tj 2.224 -1.2 Td (\b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\017, )Tj -1.149 -1.2 Td (\017\f\023\t\021\026\021\036\035\034\027\026\016 \035\026\002\024\030\026\ \021\024\030\017\016 )Tj -0.465 -1.2 Td (\n\036\007\017\006\017\027\f\022\017\b \017\007\036\035\017\005 \203\230\ \230 \233\204 )Tj 5.114 -1.2 Td (\025\206\204\211,)Tj -5.469 -1.2 Td (\203\230\214 \024\030\020\026\027\017\004\036\f\022\024\020\024 \f\017\027\ \021\036\026 \025\206\211)Tj 19.016 6 Td (Na-\025\204\037)Tj -0.049 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.83 -1.2 Td (9,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 13.196 1.2 Td (\215\200\215)Tj -0.794 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1)Tj -47.125 -1.433 Td (2)Tj 18.607 0 Td (Na-\025\204\037)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\214\036\r\024\235\035\024\022\f\026\006\017\027)Tj 1.326 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2/1,05)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 13.961 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.83 -1.2 Td (9,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 13.196 1.2 Td (\215\200\215)Tj -0.794 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1)Tj -47.125 -1.433 Td (3)Tj 22.371 0 Td (Na-\025\204\037)Tj -0.049 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.213 -1.2 Td (+)Tj /Span<>> BDC ( )Tj EMC (\247\024\020\036\022\f\024\035)Tj -1.273 -1.2 Td (9,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3/4,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 15.085 2.4 Td (\215\200\215)Tj -0.794 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1)Tj -47.125 -2.633 Td (4)Tj 22.371 0 Td (Na-\025\204\037)Tj -0.049 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.213 -1.2 Td (+)Tj /Span<>> BDC ( )Tj EMC (\247\024\020\036\022\f\024\035)Tj -1.273 -1.2 Td (9,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3/4,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.321 2.4 Td (\215\200\215)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\214\036\r\024\235\035\024\022\f\026\006\017\027)Tj 0.581 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1/0,73)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,07)Tj -44.736 -2.633 Td (5)Tj 19.042 0 Td (Na-\025\204\037)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\020\017\026\035\031\030\024\027\024\r\026\016 )Tj 1.669 -1.2 Td (\022\017\f\035\024\021\026 \(\f\n\036\f\034\))Tj 1.611 -1.2 Td (9,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 2.4 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.58 -1.2 Td (10,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 10.01 1.2 Td (\215\200\215)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\204\036\021\030\024\027\017\007\026\024\035)Tj 0.752 -1.2 Td (4,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2/1,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj -45.236 -2.633 Td (6)Tj 3.944 0 Td (\230\f\023\024\035\034\031\036\n\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 )Tj 4.173 -1.2 Td (\023\030\026\022\021\017\022\036)Tj 13.472 1.2 Td (\204\036\n\002\030\026\027\026 \017\n\023\035\026\027\021\017\030\031\036\ \n\026\016 \002\017\024\023\024\035\017\n\036\030\027\026\016 \(\002\026\ \022\021\036\030\017\026\035\034\027\t\005 \f\024\023\024\035\017\n\036\030\ )Tj 4.037 -1.2 Td (\023\024\035\017\024\022\f\017\002\031\021\017\030\026\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\026\035\036\030\026\021\024\n, \023\024\035\017\220\021\036\035\036\027\ \020\035\017\022\024\035\034\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.9018 56.0378 Tm (67)Tj ET endstream endobj 1260 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 505.5841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 505.5841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 468.3763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 468.3763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 414.3071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.118 Tw 9 0 0 9 119.0551 730.4919 Tm [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: )0.5(the )0.5(mater)-37(ials )0.5(of )0.5(the p)46(resent )0.5(study )0.5(w)12(ere ne)10(w )0.5(sam)16(ples \(g)14(roups N)17(o. )0.5(1\2315\) of )0.5(multilayer )]TJ 0.113 Tw 0 -1.111 TD [(polymer membranes \(5 g)14(roups dif)-40(fer)-37(ing in com)16(position with addition )0.5(of v)16(ar)-37(ious antibacter)-37(ial ag)12(ents, a contrast )]TJ 0.029 Tw T* [(ag)12(ent in dif)-39.9(ferent layers\) and the membrane, the im)16(planted biopolymer \(g)14(roup N)17(o. 6\). S)28.1(tudy design: e)-15(xper)-36.9(imental )]TJ 0.051 Tw T* [(sing)13(le-center com)16(parativ)13.1(e p)45.9(rospectiv)13.1(e with sim)16.1(ple blinding. S)28(tudy ter)-14(ms)]TJ /Span<>> BDC ( )Tj EMC (\227 1 month. The end point of the study is )Tj 0.022 Tw T* [(the lev)13(el of intraluminal p)46(ressure at the air e)-15(xpiration in the anastomosis zone. The ef)-40(fectiv)13(eness studies w)12(ere con)]TJ 0 Tw (-)Tj 0.02 Tw 0 -1.111 TD [(ducted by pneumop)46(ressing \(using an automatic tonometer\) a section of the s)33(mall intestine af)-45.9(ter applying a sing)13(le-)]TJ -0.002 Tw 0 -1.111 TD [(row intestinal anastomosis, on which the test sam)16(ples w)12(ere placed. The p)46(ressure inside the sing)13(le-row \(g)14(roup 7\) and )]TJ -0.009 Tw T* [(double-row \(g)14(roup 8\) anastomoses w)13(as also measured without the use of membranes. The study used 7 cm long \ and )]TJ 0.028 Tw T* [(2 cm wide sections of the s)32.9(mall intestine tak)17(en from ten male cad)26(av)13(ers ag)12(ed betw)12(een 30 and 45. The sam)16(ples w)12(ere )]TJ 0.023 Tw T* [(collected within 24 hours of death. Each g)14(roup included 10 sam)16(ples.)]TJ 0.029 Tw T* [(RESUL)30(T)-10(S: the highest median of p)46(ressure v)16(alue \(85 [79.5; 87] mm Hg\) w)13(as obser)-42(v)13(ed in g)14(roup 8 \(double-row anas)]TJ 0 Tw (-)Tj 0.025 Tw T* [(tomosis\), with a median dif)-39.9(ference of 0.5 com)16(pared to g)14(roup 1 \(84.5 [83; 85] mm Hg\) \(using membranes without )]TJ 0.013 Tw T* [(antibacter)-36.9(ial ag)12.1(ents\) and g)14(roup )0.5(4 \(84.5 [83.25; 86] )0.5(mm Hg\) \(using )0.5(membranes with Lev)13(of)-21.9(lo)14(x)10(acin in the PVP layer )]TJ 0.021 Tw T* [(and )0.6(Y)48(og)12(e)-15(xol )0.5(in )0.5(the )0.6(sodium )0.6(alginate )0.5(layer\). )0.6(How)12(ev)13(er)61(, )0.6(the )0.5(v)16(alues )0.6(of )0.5(g)14(roup )0.6(8 )0.5(are )0.5(statistically )0.5(signif)-43(icantly )0.5(higher )0.5(than )]TJ 0.093 Tw 0 -1.111 TD [(the v)16(alues of g)14(roups 6 \(62 [60.5; 63] mm Hg\) and 7 \(63.5 [59.5; 65.75] mm Hg\) by 23\ \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.002\) and 21.5 )Tj 0.023 Tw 0 -1.111 TD (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.004\) respectiv)13(ely)32(.)]TJ 0.133 Tw T* [(C)21(ON)22(CLUSION: the study sugg)12(ests that the mechanical shelter of the intestinal anastomosis with ne)10(w membrane )]TJ 0.023 Tw T* [(sam)16(ples is a fairly ef)-40(fectiv)13(e method for p)46(rev)13(enting their failure.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 545.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( surgical membranes, polymers, antibacter)-36.9(ial ag)12(ents, e)-15(xper)-37(iment, intestinal anastomoses, tightness)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FIN)16(A)31(N)23(CIN)23(G:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.966 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC (study had no sponsorship)Tj /T1_1 1 Tf 0.057 Tc 0.064 Tw -4.966 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.043 Tc 0.073 Tw 6.769 0 Td [( L)-41.1(a)-27.5(z)-27.5(a)-10.2(r)-19.1(e)-11.4(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-23(.)-23.5(, L)-12.2(i)-2.5(p)-20(a)-18.2(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-23(.)-23.5(, S)-29.3(e)-15.8(v)-18.7(e)-12.1(r)-56.4(i)-3.2(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.8(A)-23(.)-23.5(, K)-15.9(u)-10.4(d)-10.4(r)-60.6(y)-24.2(a)-10.7(v)-54.9(t)-48.9(s)-22.9(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)-1.9(N)-2.8(.)-23.5(, K)-11.1(o)-9.2(m)-8.3(a)-10.2(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-23(. Ef)-62.5(f)-28.5(e)-19.1(c)-41.5(t)-46.2(i)-14.5(v)-18.7(e)-11.5(n)-16(e)-22.8(s)-22.3(s o)-12.1(f n)-16.1(e)-12.5(w p)-22.3(o)-15.7(l)-8.2(y)-27.5(m)-16.6(e)-12.1(r)43( )]TJ 0.028 Tc -0.035 Tw -6.774 -1.2 Td [(m)-16.1(e)-11.1(m)-7.9(b)-13.3(r)-30.4(a)-7.1(n)-15.6(e)-22.4(s f)-24.8(o)-11.3(r i)-2.7(n)-16.9(t)-24.2(e)-22.4(s)-28.8(t)-45.7(i)-2.7(n)-7.4(a)-10.9(l a)-7.1(n)-7.4(a)-26.1(s)-28.8(t)-21.4(o)-8.8(m)-11.9(o)-15.4(s)-22.4(e)-22.3(s)-15.1(. )]TJ /T1_0 1 Tf 0.034 Tc -0.034 Tw [(K)10.3(o)-3.6(lo)-3.6(p)-1.1(rok)-22.7(t)-1.3(o)-3.7(lo)-6.8(g)-16.7(i)3.1(a)2.3(.)]TJ /T1_2 1 Tf 0.028 Tc -0.035 Tw 24.473 0 Td [( 2)-8.4(0)-3.3(2)4.6(6)20.4(;)10.3(2)-1(5)1.4(\()38.2(1)44.7(\))15(:)4.6(6)-2(5)-22.2(\226)44.7(7)11.7(0)7(. \(i)-2.7(n R)-6(u)-21.5(s)-21.8(s)-15(.)43.7(\))10.8(. h)-16.7(t)-49(t)-28.9(p)-18.2(s)-7.5(:)2.3(/)85.2(/)36.9(d)-10.7(o)-12(i.)3.1(o)-11.3(r)-16.2(g)-22.3(/)11.6(1)14.5(0)6.9(.)-5.1(3)8.4(3)-15.5(8)1.8(7)5.1(8/)8.4(2)-8.4(0)9.7(7)-1.4(3)-12.8(-)41.6(7)11.2(5)0.9(5)-8.5(6)-26.2(-)10.2(2)-8.5(0)-3.3(2)4.7(6)-26.3(-)]TJ 0.067 Tc -0.067 Tw -24.473 -1.2 Td [(2)22.6(5)0.5(-)79.1(1)50.9(-)-4(6)21.6(5)0.5(-)65.2(7)35.2(0)]TJ /T1_1 1 Tf 0.01 Tc 0.057 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.062 Tw 10.655 0 Td ( \205\027\021\027\032\022\025\031\021 \220\026\022\023\032\022\235 \003\025\ \030\032\027\027\021\022\007, \214\216\221\217\210 \211\217 \202\216\215\ \210 \215\022\025\016\030\032\020\021\020 \206\031\024\024\022\022, \r\f\ .)Tj /Span<>> BDC ( )Tj EMC (\202.)Tj /Span<>> BDC ( )Tj EMC (\215\020\032\n\024\020, \030.)Tj /Span<>> BDC ( )Tj EMC (3, \202\r\032\024\n, 305041, \206\031\024\024\022\t; )Tj 0.023 Tw -10.66 -1.2 Td (\023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7)Tj /Span<>> BDC ( )Tj EMC (\(920\) 262-15-55; e-mail: dmitriy.severinov.93@mail.ru)Tj /T1_1 1 Tf 0.01 Tc 0.09 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.095 Tw 14.195 0 Td [( Dmitr)-42.9(y A. Sev)13(er)-36.9(inov)63(, K)17(ursk S)28(tate Medical U)22(niv)13(ersity)42(, K. Mar)-32(x st., 3, K)17(ursk, 305041, R)22(ussia; e-mail: dmitr)-36.9(iy)32(.)]TJ 0 Tw -14.199 -1.2 Td [(sev)13(er)-37(inov)53(.93@mail.ru)]TJ 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 28.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 28.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 359.4899 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.147 Tw 10 0 0 10 70.8661 335.1339 Tm [(\210\023\036\030\026\006\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\024\030\020\026\027\026\b )0.5(\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\024\004)Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD (\027\024-\022\017\001\036\004\027\024\n \021\030\026\022\021\036 \(\240\025\ \221\) \016\r\035\016\033\021\f\016 \027\026\017\002\024\035\036\036 \030\ \026\f)Tj 0 Tw (-)Tj 0.533 Tw T* (\023\030\024\f\021\030\026\027\201\027\027\t\n\017 \r\026\030\017\026\027\ \021\026\n\017 \b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036)Tj 0 Tw (-)Tj 0.342 Tw T* (\001\026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 [1]. \203\036\024\021\ \255\036\n\035\036\n\t\n )Tj 0.128 Tw T* (\220\021\026\023\024\n \024\f\027\024\r\027\024\005 \n\026\f\f\t \024\023\ \036\030\026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \024\021)Tj 0 Tw (-)Tj 0.196 Tw T* (\007\036\035\026\b \240\025\221 \016\r\035\016\036\021\f\016 \235\024\030\ \n\017\030\024\r\026\027\017\036 \022\017\001\036\004\027\t\b \026\027\026\ )Tj 0 Tw (-)Tj 0.272 Tw T* (\f\021\024\n\024\024\r \(\025\202\) \007\035\016 \r\024\f\f\021\026\027\ \024\r\035\036\027\017\016 \027\036\023\030\036\030\t\r\027\024\f\021\017\ )Tj 0.081 Tw T* (\022\017\001\036\004\027\017\022\026 [2]. \203\036\f\n\024\021\030\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\t\036 \007\024\f\021\017\032\036)Tj 0 Tw (-)Tj 0.105 Tw T* [(\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.65 0 Td (\b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC 5.01 0 Td [(\002\017\024\017\027\032\036\027\036\030\017\017, )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )]TJ 0.029 Tw -7.66 -1.218 Td (\022\017\001\036\004\027\t\b \026\027\026\f\021\024\n\024\024\r \(\203\025\ \202\) \024\f\021\026\201\021\f\016 \027\026\004\017\021\036\035\034\027\ \024\005 )Tj 0.153 Tw T* (\031\020\030\024\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\n \023\036\030\017\024\007\036 [3]. )Tj 0.146 Tw T* (\203\025\202)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\f\021\026\021\024\004\027\024 \017\031\004\036\027\027\024\ \036 \024\f\035\024\032\027\036\027\017\036, \022\024\021\024\030\024\036\ )Tj 0.173 Tw T* (\023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\021\024\027\017\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\220\021\026\023\027\t\n \023\024\r\021\024\030\027\t\n\ )Tj 0.139 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\017\n )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026\n, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 14.717 0 Td [(\r )0.5(\f\035\031\004\026\036 )0.6(\023\024\007\027\036\005 )]TJ 0.058 Tw -14.717 -1.218 Td (\007\017\026\020\027\024\f\021\017\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \035\036\021\026\035\034\027\024\n\031 \017\f\b\024\007\031 [4]. \215\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026)Tj 0 Tw (-)Tj 0.228 Tw T* (\f\021\024\021\026 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\ \021\017 \026\r\017\f\017\021 \024\021 \n\027\024\020\017\b \235\026\022\ \021\024)Tj 0 Tw (-)Tj 0.252 Tw T* (\030\024\r. \221\026\022, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \220\027\021\036\030\024-\220\ \027\021\036\030\024\026\027\026\f\021\024)Tj 0 Tw (-)Tj 0.261 Tw T* [(\n\024\026 )0.5(\004\026\f\021\024\021\026 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\027\036 )0.5(\023\030\036\r\t\001\026\036\021 )0.6(3% )]TJ 0.005 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\t\b \r\n\036\001\026\021\036\035\034\f\021\r\026\b\ , \026)Tj /Span<>> BDC ( )Tj EMC (\r \031\030\020\036\027\021\027\t\b \f\035\031\004\026\016\b )Tj -0.027 Tw T* (\007\024\f\021\017\020\026\036\021 9,8% [5]. \222\021\024\017\021 \024\021\ \n\036\021\017\021\034, \004\021\024 \203\025\202 \004\026\013\036 \r\024\ )Tj 0 Tw (-)Tj 0.02 Tw T* (\027\017\022\026\036\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \253\027\017\022\017\b\273\ \022\024\035\024\030\036\022\021\026\035\034\027\t\b )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\024\r [6].)Tj 0.03 Tc 0.089 Tw 23.244 28.009 Td (\210\f\024\002\031\033 \020\030\031\023\023\031 \023\026\006\017\036\027\ \021\024\r \235\024\030\n\017\030\031\033\021 \023\024\f\021\030\026\007\ \026\r)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.185 Tw T* (\001\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \007\024\030\024\032\027\024-\021\030\ \026\027\f\023\024\030\021\027\t\b \023\030\024\017\f)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.213 Tw T* [(\001\036\f\021\r\017\005, \022\024\020\007\026 \017\n\036\033\021 \n\036\ \f\021\024 \030\026\030\t\r\t \022\017\001\036\004\027\024\005)30( )]TJ 0.399 Tw T* (\f\021\036\027\022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 \023\036\030\r\017\004)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.507 Tw T* (\027\024 \r\t\023\024\035\027\016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\031\f\035\024\r\017\016\b \017\027\235\017\006\017\030\024\r\026\027\027\ \024\005)30( )]TJ 0.115 Tw T* [(\002\030\033\001\027\024\005 )0.5(\023\024\035\024\f\021\017 [7]. )0.5(\221\026\022\032\036 \036\013\036 \002\024\035\036\036 \021\016\032\036\035\ \024\005)30( )]TJ 0.183 Tw T* (\022\026\021\036\020\024\030\017\036\005 \023\026\006\017\036\027\021\024\ \r \016\r\035\016\033\021\f\016 \030\026\027\036\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\b\024\007\036)30( )]TJ -0.013 Tw T* [(\r\024\036\027\027\t\b )0.5(\022\024\027\235\035\017\022\021\024\r )0.5(\017-\026 )0.5(\r\t\f\024\022\024\005 )0.5(\220\027\036\030\020\017\017 )0.5(\021\030\026\r)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.116 Tw T* [(\n\017\030\031\033\013\036\020\024 )0.5(\026\020\036\027\021\026 )0.5(\(\023\031\035\017, )0.5(\024\f\022\024\035\022\017\), )0.5(\004\021\024 )0.6(\023\030\017\r\024\007\017\021)30( )]TJ 0.072 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\027\017\022\026\033\013\017\n \030\026\027\036\027\017\016\n\ \002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\036\036)30( )]TJ 0.633 Tw T* [(\n\026\f\f\017\r\027\024\005 \024\002\f\036\n\036\027\036\027\027\024\f\021\ \017 \n\017\022\030\024\024\030\020\026\027\017\n\026\n\017)30( )]TJ 0.065 Tw T* [([8]. \233\021\024 )0.5(\024\022\026\t\r\026\036\021 \024\021\030\017\006\026\021\036\035\034\027\ \024\036 \r\035\017\016\027\017\036 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc T* (\f\021\024\021\031 \203\025\202)Tj /Span<>> BDC ( )Tj EMC ([9].)Tj 0.016 Tc 0.371 Tw T* [(\212\035\016 \023\030\024\235\017\035\026\022\021\017\022\017 \203\025\202\ , \031\f\022\024\030\036\027\017\016 \030\036\020\036\027\036\030\026\006\ \017\017)16( )]TJ 0.069 Tw T* (\021\022\026\027\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \025\202 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\016 \220\235\235\036\022\021\017\r\027\024\f\ \021\017 \b\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc -0.02 Tw T* (\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\034\ \f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.225 Tw T* (\024\027\027\024\n \023\036\030\017\024\007\036 \030\026\030\026\002\026\ \021\t\r\026\033\021\f\016 \027\024\r\t\036 \002\017\024\n\026\021\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.224 Tw T* [(\030\017\026\035\t, \f\024\007\036\030\032\026\013\017\036 \026\027\021\017\ \002\026\022\021\036\030\017\026\035\034\027\t\036 \f\030\036\007\f\021\r\ \026.)16( )]TJ 0.315 Tw T* [(\221\026\022\017\036 \017\007\036\035\017\016 \(\023\035\036\027\022\017\ , \n\036\n\002\030\026\027\t\), \024\002\035\026\007\026\033\013\017\036\ )16( )]TJ 0.473 Tw T* [(\030\016\007\024\n \023\024\017\021\017\r\027\t\b \f\r\024\005\f\021\r,\ \021\026\022\017\b \022\026\022 \r\t\f\024\022\026\016)16( )]TJ 0.273 Tw T* (\026\007\020\036\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 \f\021\036\027\022\036, \002\017\024\007\ \036\020\030\026\007\026\006\017\016, \021\030\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.351 Tw T* [(\002\031\033\021 \r\f\036\f\021\024\030\024\027\027\036\020\024 \021\036\ \f\021\017\030\024\r\026\027\017\016 [10]. \200\026\032\027\t\n)16( )]TJ 0.148 Tw T* (\220\021\026\023\024\n \016\r\035\016\036\021\f\016 \024\006\036\027\022\ \026 \020\036\030\n\036\021\017\004\027\024\f\021\017 \025\202 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC [(\017\b)16( )]TJ -0.016 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1274 56.0378 Tm (66)Tj ET endstream endobj 1233 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1234 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1235 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1236 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1237 0 obj 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0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-65-70)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 74.5551 695.3259 Tm [(\036\004\t\r\017 \237\216\216\004\r)-9.9(\026\n\b\t\025\016)-10(\026\n \224\005\n\024\004\t\004\t\n\213 \224\025\020\n\024\004\005\t\217\ \220 )]TJ 2.546 -1.105 Td [(\024\004\024\255\005\017\t \202)-21(\020\213 \r\n\204\004\225\t\217\220 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\025\b)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\035\017\212\017\005\004\t\r)10(\025\022)-23.2(\021.\f)-31(.)]TJ 8.162 0 0 8.162 134.7965 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 139.4325 649.822 Tm [(, \035\n\224\017\026)11(\025\b\022)-23.2(\021.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 224.1394 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 228.7753 649.822 Tm [(, \001\004\b\004\005\n\t\025\b\022)-23.2(\201.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 329.652 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 334.2879 649.822 Tm [(, \037)62(\002\202\005\213\b\004\b\017\022)-23.2(\032.\007.)]TJ 0 Tw 8.162 0 0 8.162 435.823 654.484 Tm (2)Tj 14 0 0 14 440.4589 649.822 Tm (, )Tj -28.424 -1.143 Td [(\037)31(\025\024\017\005\025\b\022)-23.3(\201.\f)-30.9(.)]TJ 8.162 0 0 8.162 123.639 638.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 619.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 616.1527 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\005\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020\ .\022)-23.3(\037.\022)-23.3(\235\017\005\r\016\017, \202.\022)-23.3(3, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\037)62(\002\005\016\r, 3050)25.1(4)103(1)69(, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 595.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 592.1527 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\005\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \002\t\n\b\004\005\016\n\026)11.1(\004\026\273 \(\002\020.\022)-23.2(\033\017\202\n\234\004\b\017, \202.\022)-23.2(33, \013)62(.\022)-23.3(\037)62(\002\005\016\r, 305000, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf -0.016 Tw 9 0 0 9 90.7087 573.6488 Tm (\037\036\035\034: \021)Tj /Span<>> BDC ( )Tj EMC (\204\n\024\033\027\032\022\026\027\025\023\027 ex vivo \031\006\027\025\022\ \023\017 \204\203\203\027\n\023\022\021\025\031\024\023\017 \033\032\022\ \026\027\025\027\025\022\t \031\240\032\020\016\006\031\021 \033\031\f\022\ \026\027\032\025\013\200 \026\027\026\240\032\020\025, \032\020\016\032\020\ \240\031)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\023\020\025\025\013\200 \030\f\t \033\032\031\203\022\f\020\n\023\022\n\ \022 \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\022 \n\ \022\213\027\007\025\013\200 \020\025\020\024\023\031\026\031\016\031\021\ .)Tj 0.027 Tw T* (\215\003\036\206\002\003\035\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \026\020\023\027\032\022\020\f\020\026\022 \025\020\ \024\023\031\t\212\027\b\031 \022\024\024\f\027\030\031\021\020\025\022\t\ \024\023\020\f\022 \031\240\032\020\016\006\013 \026\025\031\b\031\024\f\ \031\235\025\013\200 \033\031\f\022\026\027\032\025\013\200 )Tj 0.086 Tw T* (\026\027\026\240\032\020\025 \(\b\032\r\033\033\013 \2421\2315, \031\023\ \f\022\007\020\005\212\022\027\024\t \024\031\024\023\020\021\031\026 \024\ )Tj /Span<>> BDC ( )Tj EMC (\030\031\240\020\021\f\027\025\022\027\026 \032\020\016\f\022\007\025\013\ \200 \020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\013\200 \024\ \032\027\030\024\023\021, )Tj -0.029 Tw T* (\n\031\025\023\032\020\024\023\025\031\b\031 \021\027\212\027\024\023\021\ \020 \021)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\027 \024\f\031\022\) \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\r\027\026\020\t \021)Tj /Span<>> BDC ( )Tj EMC (\n\f\022\025\022\007\027\024\n\031\235 \033\032\020\n\023\022\n\027 \026\ \027\026\240\032\020\025\020, \022\026\033\f\020\025\023\022\032\r)Tj 0 Tw (-)Tj -0.05 Tw 0 -1.111 TD (\027\026\020\t \240\022\031\033\031\f\022\026\027\032\025\020\t \(\b\032\ \r\033\033\020 \2426\). \220\022\016\020\235\025 \022\024\024\f\027\030\031\ \021\020\025\022\t: \204\n\024\033\027\032\022\026\027\025\023\020\f\017\ \025\031\027 \031\030\025\031\006\027\025\023\032\031\021\031\027 \024\032\ \020\021\025\022\023\027\f\017\025\031\027 )Tj 0.078 Tw 0 -1.111 TD (\033\032\031\024\033\027\n\023\022\021\025\031\027 \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\024\023\013\026 \031\024\f\027\033\f\027\025\022\027\026. \205\ \032\031\n\022 \022\024\024\f\027\030\031\021\020\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 1 \026\027\024\t\006. \202\031\025\027\007\025\020\t \023\031\007\n\ \020 \022\024\024\f\027\030\031\021\020\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.018 Tw T* [(\r\032\031\021\027\025\017 \021\025\r\023\032\022\033\032\031\024\021\027\ \023\025\031\b\031 )0.5(\030\020\021\f\027\025\022\t )0.5(\033\032\022)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\023\027\007\027\025\022\022 )0.5(\021\031\016\030\r\200\020 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC [(\016\031\025\027 \020\025\020\024\023\031\026\031\016\020. )0.5(\002\024\024\f\027\030\031\021\020\025\022\t \204\203\203\027\n\023\022\021\ )]TJ 0 Tw (-)Tj 0.021 Tw T* (\025\031\024\023\022 \033\032\031\021\031\030\022\f\022 \033\r\023\027\026\ \033\025\027\021\026\031\033\032\027\024\024\022\022 \(\024 \033\031\026\ \031\212\017\005 \020\021\023\031\026\020\023\022\007\027\024\n\031\b\031\ \023\031\025\031\026\027\023\032\020\) \r\007\020\024\023\n\020 \023\031\ \025\n\031\235 \n\022\213\n\022 )Tj 0.13 Tw T* (\033\031\024\f\027 \025\020\f\031\255\027\025\022\t \031\030\025\031\032\ \t\030\025\031\b\031 \n\022\213\027\007\025\031\b\031 \020\025\020\024\023\ \031\026\031\016\020, \025\020)Tj /Span<>> BDC ( )Tj EMC (\f\022\025\022\005 \213\021\031\021 \n\031\023\031\032\031\b\031 \033\031\ \026\027\212\020\f\022 \023\027\024\023\022\032\r\027\026\013\027 )Tj 0.124 Tw T* (\031\240\032\020\016\006\013. \020\n\255\027 \022\016\026\027\032\t\f\022\ \030\020\021\f\027\025\022\027 \021\025\r\023\032\022 \031\030\025\031\032\ \t\030\025\031\b\031 \(\b\032\r\033\033\020 \2427\) \022)Tj /Span<>> BDC ( )Tj EMC (\030\021\r\032\t\030\025\031\b\031 \020\025\020\024\023\031\026\031\016\031\ \021 \(\b\032\r\033\033\020 )Tj 0.068 Tw T* (\242 8\) \240\027\016 \022\024\033\031\f\017\016\031\021\020\025\022\t \026\ \027\026\240\032\020\025. \211)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\027 \031\240\236\027\n\023\020 \022\024\024\f\ \027\030\031\021\020\025\022\t \240\013\f\022 \022\024\033\031\f\017\016\ \031\021\020\025\013 \r\007\020\024\023\n\022 \023\031\025\n\031\b\031 )Tj -0.01 Tw T* (\n\022\213\027\007\025\022\n\020 \030\f\022\025\031\235 7 \024\026, \213\ \022\032\022\025\031\235 2 \024\026, \022\016\236\t\023\013\027 \r)Tj /Span<>> BDC ( )Tj EMC (\030\027\024\t\023\022 \023\032\r\033\031\021 \f\022\006 \026\r\255\024\n\ \031\b\031 \033\031\f\020, \r\026\027\032\213\022\200 \021)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\032\020\024\023\027 \031\023 )Tj 0.067 Tw T* (30 \030\031)Tj /Span<>> BDC ( )Tj EMC (45 \f\027\023. \207\020\240\031\032 \026\020\023\027\032\022\020\f\020, \ \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \022\024\024\f\027\030\031\021\020\025\022\t \031\024\ \r\212\027\024\023\021\f\t\f\022 \021)Tj /Span<>> BDC ( )Tj EMC (\023\027\007\027\025\022\027 \033\027\032\021\013\200 \024\r\023\031\n \024\ )Tj /Span<>> BDC ( )Tj EMC (\026\031\026\027\025\023\020 )Tj 0.023 Tw 0 -1.111 TD (\025\020\024\023\r\033\f\027\025\022\t \024\026\027\032\023\022. \211)Tj /Span<>> BDC ( )Tj EMC (\n\020\255\030\031\235 \b\032\r\033\033\027 \021\013\033\031\f\025\027\025\ \031 \033\031)Tj /Span<>> BDC ( )Tj EMC (10 \022\024\024\f\027\030\031\021\020\025\022\235.)Tj 0.046 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \024\031\b\f\020\024\025\031 \033\031\ \f\r\007\027\025\025\013\026 \021)Tj /Span<>> BDC ( )Tj EMC (\200\031\030\027 \022\024\024\f\027\030\031\021\020\025\022\t \030\020\025\ \025\013\026, \022\026\027\005\023\024\t \024\023\020\023\022\024\023\022\ \007\027\024\n\022 \016\025\020\007\022\026\013\027 \031\023\f\022)Tj 0 Tw (-)Tj 0.157 Tw T* [(\007\022\t )0.5(\026\027\255\030\r )0.5(\b\032\r\033\033\020\026\022 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 10.33 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.89 0 Td [(0,00002\). )0.5(\001\020\022\240\031\f\017\213\027\027 )0.5(\016\025\020\007\027\025\022\027 )0.6(\026\027\030\022\020\025\013 )0.5(\030\020\021\f\027\025\022\t \(85 [79,5; )0.5(87] )0.5(\026\026 )0.5(\032\023. )0.5(\024\023.\) )]TJ -0.011 Tw -11.22 -1.111 Td (\033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\025\027\021\026\031\033\032\027\024\024\022\022 \024\203\031\032\026\ \022\032\031\021\020\025\025\013\200 \n\022\213\027\007\025\013\200 \020\ \025\020\024\023\031\026\031\016\031\021 \021\013\t\021\f\027\025\031 \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \2428 \(\030\021\r\032\t\030\025\013\235 \020\025\020\ \024\023\031\026\031\016\), )Tj -0.007 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\025\022\006\027\235 \026\027\030\022\020\025 \021)Tj /Span<>> BDC ( )Tj EMC (0,5 \031\023\026\027\007\027\025\013 \016\025\020\007\027\025\022\t \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 \2421 \(84,5 [83; 85] \026\026 \032\023. \024\023\ .\) \(\024 \022\024\033\031\f\017\016\031\021\020\025\022\027\026 \026\027\ \026)Tj 0 Tw (-)Tj 0.006 Tw T* (\240\032\020\025 \240\027\016 \021\025\027\024\027\025\022\t \020\025\023\ \022\240\020\n\023\027\032\022\020\f\017\025\013\200 \024\032\027\030\024\ \023\021\) \022)Tj /Span<>> BDC ( )Tj EMC (\2424 \(84,5 [83,25; 86] \026\026 \032\023. \024\023.\) \(\026\027\026\240\ \032\020\025\020 \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\024\027\025\022\027\026 )Tj -0.023 Tw T* (\035\027\021\031\203\f\031\n\024\020\006\022\025\020 \021)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\235 \004\211\004 \022)Tj /Span<>> BDC ( )Tj EMC (\246\031\b\027\n\024\031\f\020 \021)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\235 \003\f\017\b\022\025\020\023\020 \025\020\023\032\022\t\)\ . \217\030\025\020\n\031 \016\025\020\007\027\025\022\t \b\032\r\033\033\ \013 \2428 \024\023\020\023\022\024\023\022)Tj 0 Tw (-)Tj 0.044 Tw T* (\007\027\024\n\022 \016\025\020\007\022\026\031 \033\032\027\031\240\f\020\ \030\020\027\023 \023\031\f\017\n\031 \025\020\030 \016\025\020\007\027\025\ \022\t\026\022 \b\032\r\033\033 \2426 \(62 [60,5; 63] \026\026 \032\023.\ \024\023.\) \022)Tj /Span<>> BDC ( )Tj EMC (\2427 \(63,5 [59,5; )Tj 0.023 Tw T* (65,75] \026\026 \032\023. \024\023.\) \025\020)Tj /Span<>> BDC ( )Tj EMC (23 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\) \022)Tj /Span<>> BDC ( )Tj EMC (21,5 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\), \024\031\031\023\021\027\023\024\023\021\027\025\025\031.)Tj 0.246 Tw 0 -1.111 TD [(\207\003\202\035\224\232\036\001\002\036: )0.5(\033\032\031\021\027\030\027\025\025\031\027 )0.5(\022\024\024\f\027\030\031\021\020\025\022\027 )0.6(\033\031\016\021\031\f\t\027\023 )0.5(\r\023\021\027\032\255\030\020\023\017, \007\023\031 \026\027\200\020\025\ \022\007\027\024\n\031\027 )0.5(\r\n\032\013\023\022\027 )0.5(\016\031\025\013 \202\003 )]TJ 0.023 Tw 0 -1.111 TD (\025\031\021\013\026\022 \031\240\032\020\016\006\020\026\022 \004\215 \t\ \021\f\t\027\023\024\t \033\031\023\027\025\006\022\020\f\017\025\013\026\ \026\027\023\031\030\031\026 \033\032\031\203\022\f\020\n\023\022\n\022\ \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\022 \202\003\ .)Tj /T1_2 1 Tf 0.01 Tc 0.092 Tw 8 0 0 8 42.5596 318.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.097 Tw 8.566 0 Td [( \200\022\032\r\032\b\022\007\027\024\n\022\027 )0.5(\026\027\026\240\032\020\025\013, )0.5(\033\031\f\022\026\027\032\013, )0.5(\020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\013\027 )0.5(\024\032\027\030\024\023\021\020, \204\n\024\033\027\032\022\026\027\025\ \023, )0.5(\n\022\213\027\007\025\013\027 \020\025\020\024\023\031\026\031\016\013,\ )0.6(\b\027\032\026\027)]TJ 0 Tw (-)Tj -8.571 -1.2 Td (\023\022\007\025\031\024\023\017)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\024\023\025\026\025\030\023\021\027\032\026\025\023\033:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \022\024\024\f\027\030\031\021\020\025\022\027 \025\027 \022\026\027\f\031\ \024\033\031\025\024\031\032\024\n\031\235 \033\031\030\030\027\032\255\ \n\022)Tj /T1_2 1 Tf 0.04 Tc 0.345 Tw -8.655 -2.617 Td [(\020\036\017)4.6( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.03 Tc 0.35 Tw 9.631 0 Td ( \214\026\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \214\017\023\026\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \222\036\r\036\030\017\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \025\031\007\030\016\r\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\203., \025\024\n\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202. \210\006\036\027\022\026 \220\235\235\036\022\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.257 Tw -9.636 -1.2 Td [(\027\024\f\021\017 )0.5(\023\030\017\n\036\027\036\027\017\016 )0.5(\027\024\r\t\b )0.5(\023\024\035\017\n\036\030\027\t\b )0.5(\n\036\n\002\030\026\027 )0.5(\007\035\016 )0.5(\022\017\001\036\004\027\t\b )0.5(\026\027\026\f\021\024\n\024\024\r. )]TJ /T1_1 1 Tf -0.023 Tw 35.244 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.257 Tw [( )0.5(2026; \021.)]TJ /Span<>> BDC ( )Tj EMC 12.802 0 Td [(25, )0.5(\223)]TJ /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC 5.678 0 Td [(65\22670.)23( )]TJ -0.023 Tw -53.724 -1.2 Td (https://doi.org/10.33878/2073-7556-2026-25-1-65-70)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 121.9353 205.7639 Tm [(Ef)-31(fectiv)12.1(eness of ne)11.1(w polymer membr)21(anes )]TJ 3.063 -1.167 Td (for intestinal anastomoses)Tj 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 160.26 Tm [(Victor\022)-23.2(A)-31(.\022)-23.3(La)20(z)15(ar)31(enk)11(o)]TJ 8.162 0 0 8.162 153.4764 164.922 Tm (1)Tj 0.023 Tw 14 0 0 14 158.1123 160.26 Tm [(, Viach)11(eslav\022)-23.2(A)-31(.\022)-23.3(Lipatov)]TJ 0 Tw 8.162 0 0 8.162 287.0907 164.922 Tm (1)Tj 0.023 Tw 14 0 0 14 291.7266 160.26 Tm [(, Dmitriy\022)-23.2(A)-31(.\022)-23.3(Se)11(v)12(erinov)]TJ 0 Tw 8.162 0 0 8.162 414.8666 164.922 Tm (1)Tj 14 0 0 14 419.5026 160.26 Tm (, )Tj -26.927 -1.143 Td [(T)40(at)-20(y)21(ana\022)-23.2(N.\022)-23.3(K)31(udr)-31(y)21(avtse)11(v)10(a)]TJ 8.162 0 0 8.162 184.0384 148.922 Tm (2)Tj 0.023 Tw 14 0 0 14 188.6743 144.26 Tm [(, Dmitr)-30.9(y\022)-23.3(A)-31(.\022)-23.3(K)41(omar)20(ov)]TJ 0 Tw 8.162 0 0 8.162 304.5911 148.922 Tm (1)Tj 5.83 0 0 5.83 42.5197 129.9208 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 126.5908 Tm [(K)31(ur)20(sk State Medical Univ)12.1(er)20(sit)-20(y \(K. Marx\022)-23.3(st., 3, K)31(ur)20(sk, 3050)25.1(4)103(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 117.9208 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 114.5908 Tm [(K)31(ur)20(sk State Univ)12(er)20(sit)-19.9(y \(Radishch)11(e)11(v)10(a\022)-23.3(st., 33, K)31(ur)20(sk, 305000, Russia\))]TJ /T1_1 1 Tf 0.047 Tw 9 0 0 9 90.7087 96.0869 Tm [(AIM: ev)16(aluate )0.5(the ef)-40(fectiv)13(eness )0.5(of ne)10(w polymer membranes )0.5(for p)46(rev)13(ention of intestinal anastomoses leak)11(ag)12(e in e)-15(x )]TJ 0.023 Tw T* [(viv)13(o e)-15(xper)-36.9(iment.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 582.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 573.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 104.5913 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 95.664 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.7895 56.0378 Tm (65)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 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[(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 \220\n\005\002\005\013\n\225\ \004\016\r)10(\025\221 \224\025\024\025\234\n )]TJ 0 -1 TD [(\224\005\n\022\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\ \r\n \t\017\022\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 39.559 1 Td [(A dif)-30.9(fer)31(entiated algorithm for pr)20(oviding sur)31(gical car)31(e )]TJ 0.177 -1 Td [(for\022r)31.1(ectal injuries at th)10.9(e\022stages of\022medical e)11(v)10(acuation)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.037 Tw 10 0 0 10 42.5197 724.8299 Tm [(\021\036\b\027\017\004\036\f\022\017\b )0.6(\024\001\017\002\024\022 )0.5(\n\036\021\024\007\017\022\017 )0.6(\022\024\035\024\f\021\024\n\017\017. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.306 0 Td (\r\027\036)Tj 0 Tw (-)Tj 0.185 Tw -20.306 -1.218 Td (\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (35,7% \022\035\017\027\017\004\036\f\022\017\b \027\026\002\035\033)Tj 0 Tw (-)Tj 0.295 Tw 0 -1.218 TD [(\007\036\027\017\005 )0.6(\023\024\021\030\036\002\024\r\026\035\026\f\034 )0.5(\030\036\036\022\006\017\016 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017. )0.5(\200\024 )]TJ 0.195 Tw T* (\r\f\036\b \f\035\031\004\026\016\b \r\t\f\024\022\024\036 \r\027\036\002\ \030\033\001\017\027\027\024\036 \217\215\025 \027\036 \002\t\035\024 )Tj 0.06 Tw T* [(\030\026\f\023\024\027\026\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.374 0 Td [(\023\030\036\007\t\007\031\013\017\b )0.6(\220\021\026\023\026\b. )0.5(\222\026\027\026\006\017\024\027\027\026\016 )0.6(\030\036)]TJ 0 Tw (-)Tj 0.074 Tw -6.374 -1.218 Td (\035\026\023\026\030\024\021\024\n\017\016 \023\030\017\n\036\027\016\035\ \026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036 \r)Tj /Span<>> BDC ( )Tj EMC (46,2% \f\035\031)Tj 0 Tw (-)Tj -0.012 Tw 0 -1.218 TD (\004\026\036\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r\024 2-\005 \020\030\031\023\023\036, \f\024\024\021\r\036\021\f\021\r\ \036\027\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (54,7% \027\026\002\035\033)Tj 0 Tw (-)Tj 0.162 Tw 0 -1.218 TD (\007\036\027\017\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\027\021\031\002\026\006\017\033 \021\024\027\022\024\ \005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.141 Tw T* (\007\036\022\024\n\023\030\036\f\f\017\017 \r\t\023\024\035\027\016\035\017\ \r)Tj /Span<>> BDC ( )Tj EMC (40,8% \f\035\031\004\026\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031)Tj 0 Tw (-)Tj 0.165 Tw T* (\021\030\017\002\030\033\001\017\027\027\t\b \217\215\025 \017)Tj /Span<>> BDC ( )Tj EMC (\r 23,8% \022\035\017\027\017\004\036\f\022\017\b \027\026\002\035\033)Tj 0 Tw (-)Tj 0.114 Tw T* (\007\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC 4.723 0 Td [(\r\027\036\002\030\033\001\017\027\027\t\b )0.5(\217\215\025. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (9,5% \027\026\002\035\033\007\036\027\017\005 )Tj 0.042 Tw -4.723 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\b\ \007\024\023\024\035\027\017\021\036\035\034\027\024 \031\001\017\r\026\ )Tj 0 Tw (-)Tj -0.046 Tw 0 -1.218 TD [(\035\017 \030\026\027\t \n\024\004\036\r\024\020\024 \023\031\t\030\016\ . )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (36,5% \f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023)Tj 0 Tw (-)Tj 0.129 Tw 0 -1.218 TD (\023\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r 33,3% \027\026\002\035\033\007\036\027\017\005 \r\024 2-\005 \020\030\ \031\023\023\036 \r\t\023\024\035\027\016\035\017 )Tj 0.056 Tw 0 -1.218 TD (\023\030\024\004\017\036 \024\023\036\030\026\006\017\017, \027\026\023\030\ \016\n\031\033 \027\036 \f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017)Tj 0 Tw (-)Tj 0.012 Tw T* (\036\n \023\030\016\n\024\005 \022\017\001\022\017. \205\024\030\n\017\030\ \024\r\026\027\017\036 \020\027\024\005\027\t\b \026\002\f\006\036\f\f\024\ \r )Tj 0.133 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.883 0 Td [(\235\035\036\020\n\024\027\t )0.5(\021\026\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.479 0 Td [(\024\f\027\024\r\027\024\005 )0.6(\020\030\031\023\023\036 )0.5(\027\036 )0.5(\026\030\036\020\017\f\021\030\017)]TJ 0 Tw (-)Tj 0.028 Tw -8.363 -1.218 Td (\030\024\r\026\027\t. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \017\n\036\035\ \017 \n\036\f\021\024 \020\027\024\005\027\024-\027\036)Tj 0 Tw (-)Tj 0.125 Tw T* [(\022\030\024\021\017\004\036\f\022\017\036 )0.5(\017\n\036\027\036\027\017\016 )0.5(\025\215\221, \024\021\n\036\004\036\027\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (2-\036 \f\031\021\022\017 )Tj -0.024 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.683 0 Td [(12,5% )0.5(\027\026\002\035\033\007\036\027\017\016\b, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.766 0 Td [(3-\036 )0.5(\f\031\021\022\017 \017)]TJ /Span<>> BDC ( )Tj EMC 4.704 0 Td (\002\024\035\036\036)Tj /Span<>> BDC ( )Tj EMC 2.624 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (62,5% )Tj 0 Tw -17.775 -1.218 Td (\f\035\031\004\026\036\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 444.7358 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.28 Tw 10 0 0 10 42.5197 420.3798 Tm [(\217\036\031\035\034\021\026\021\t )0.6(\023\030\024\r\036\007\201\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024\r\024\035\016\033\021 )]TJ 0.129 Tw T* [(\027\026\020\035\016\007\027\024 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\021\034 )0.6(\f\024\r\030\036\n\036\027\027\t\036 )0.5(\007\026\027\027\t\036 )]TJ 0.245 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\f\021\017\022\026\b \217\215\025, \024\ \002\255\201\n\036 \024\022\026\026\027\017\016 \b\017\030\031\030\020\017\ )Tj 0 Tw (-)Tj 0.124 Tw T* [(\004\036\f\022\024\005 )0.5(\023\024\n\024\013\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 8.164 0 Td [(\233\204\233, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\f\030\024\022\026\b \017)]TJ /Span<>> BDC ( )Tj EMC 9.798 0 Td (\b\026\030\026\022\021\036\030\036 )Tj 0.227 Tw -17.961 -1.218 Td (\017\n\036\r\001\017\b \n\036\f\021\024 \024\f\035\024\032\027\036\027\017\ \005. \222\017\f\021\036\n\026\021\017\026\006\017\016 \023\024\035\031\ )Tj 0 Tw (-)Tj 0.341 Tw T* [(\004\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 \023\024\r\024\035\017\035\026\ )0.5(\030\026)]TJ 0 Tw (-)Tj 0.257 Tw T* (\030\026\002\024\021\026\021\034 \007\017\235\235\036\030\036\027\006\017\ \030\024\r\026\027\027\t\005 \026\035\020\024\030\017\021\n \024\022\026\ \026\027\017\016 )Tj 0.078 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233, \023\024\r\024\035\016\033\013\017\005 \030\036\020\035\026\ )Tj 0 Tw (-)Tj 0.045 Tw T* (\n\036\027\021\017\030\024\r\026\021\034 \027\036 \021\024\035\034\022\024\ \024\002\255\201\n \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\ \004\036\027\017\016, )Tj 0 Tw T* (\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\033 \025\215\221.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.616 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.8()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.027 Tc 0.643 Tw [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 19.17 0 Td ( )Tj EMC [(\002)1.9(.)0.5(\224.)-19.2(,)-27( )]TJ -0.01 Tc 0.01 Tw -19.17 -1.218 Td [(\215)-1.6(\r)-3.4(\024\020)-5.5(\022)-12.3(\f)-6.7(\031\021)]TJ /Span<>> BDC 3.837 0 Td ( )Tj EMC [(\211)14.3(.)-2.7(\003)-12.2(.)-2.2(,)-10( \003)9.9(\240)-8.5(\030)-13.8(\r)-14.3(\032)-7(\020)-24.3(\200)-11.9(\026)-3.1(\020)-5.7(\025)-6.2(\031\021)]TJ /Span<>> BDC 8.093 0 Td ( )Tj EMC [(\206)83.9(.)66.5(\214)44.8(.)]TJ /T1_1 1 Tf 0 Tc 1.042 Tw -11.93 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.4(\024)-4.3(\r)10.3(:)]TJ /T1_4 1 Tf -0.027 Tc 1.069 Tw [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 18.744 0 Td ( )Tj EMC [(\002)1.8(.)0.5(\224.)-19.1(,)-27( )]TJ -0.004 Tc 0.004 Tw -18.744 -1.218 Td [(\003)15.9(\240)-2.5(\030)-7.8(\r)-8.3(\032)-1(\020)-18.4(\200)-5.8(\026)2.9(\020\025\031)5.6(\021)]TJ /Span<>> BDC 5.79 0 Td ( )Tj EMC [(\206)89.9(.)72.5(\214)50.8(.)]TJ /T1_1 1 Tf 0.018 Tc 2.182 Tw -5.79 -1.218 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.8(:)]TJ /T1_4 1 Tf -0.027 Tc 2.227 Tw 13.549 0 Td [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 4.037 0 Td ( )Tj EMC [(\002)1.8(.)0.5(\224.)-19.1(,)-27( )]TJ -0.004 Tc 0.004 Tw -17.586 -1.218 Td [(\003)15.9(\240)-2.5(\030)-7.8(\r)-8.3(\032)-1(\020)-18.4(\200)-5.8(\026)2.9(\020\025\031)5.6(\021)]TJ /Span<>> BDC 5.79 0 Td ( )Tj EMC [(\206)89.9(.)72.5(\214)50.8(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -5.79 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.027 Tc 0.027 Tw 7.694 0 Td [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 1.838 0 Td ( )Tj EMC [(\002)1.8(.)0.5(\224.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -9.531 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \215)-1.6(\r)-3.4(\024\020)-5.5(\022)-12.3(\f)-6.7(\031\021)]TJ /Span<>> BDC 11.204 0 Td ( )Tj EMC [(\211)14.3(.)-2.7(\003)-12.2(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 12.04 53.583 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.451 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.3(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( I)10(g)-2.5(o)1.4(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)11(i)8.4(m)-6.5(, )]TJ 0 Tw 0 -1.218 TD [(V)-5.5(i)0.9(t)2.3(all)11.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(us)7.8(a)-2(i)7.5(l)2.9(o)-0.6(v)33.6(, R)-4.1(i)8.4(n)4.8(a)-4.9(t F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)-5.9(d)5.2(u)6.1(r)7.7(a)1.7(k)5.3(h)5.3(m)4.3(a)-0.8(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf -0.013 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.2(s)-12.9(s)-16.5(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.6(h)-5.3(e m)1.9(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf [( I)10(g)-2.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)10.9(i)8.4(m)-6.4(, )]TJ -0.005 Tc 0.005 Tw 0 -1.218 TD [(R)-9.1(i)3.4(na)-9.9(t)-5( F)60.2(.)]TJ /Span<>> BDC 3.01 0 Td ( )Tj EMC [(A)1(b)-10.9(du)1.1(r)2.7(a)-3.2(khm)-0.7(a)-5.8(n)-3.1(o)-5.6(v)]TJ /T1_1 1 Tf -0.007 Tc 1.114 Tw -3.01 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( )0.6(p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf 0 Tc 1.107 Tw 10.195 0 Td [( )0.5(I)10(g)-2.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC 4.275 0 Td [(Y)33.7(u)7.7(. )0.6(K)10.9(i)8.4(m)-6.5(, )0.5(R)-4.1(i)8.4(n)4.9(a)-4.9(t )]TJ -0.005 Tc 0.005 Tw -14.47 -1.218 Td [(F)60.2(.)]TJ /Span<>> BDC 0.692 0 Td ( )Tj EMC [(A)1(b)-10.9(du)1.1(r)2.7(a)-3.2(khm)-0.7(a)-5.8(n)-3.1(o)-5.6(v)]TJ /T1_1 1 Tf 0 Tc 0 Tw -0.692 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf -0.008 Tc 0.008 Tw [( I)2(g)-10.5(o)-6.7(r)]TJ /Span<>> BDC 9.742 0 Td ( )Tj EMC [(Y)25.7(u.)-8( K)2.9(im)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -9.742 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( V)-5.5(i)0.9(t)2.3(all)11(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(us)7.9(a)-2(i)7.4(l)2.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.006 Tc 0.424 Tw 0 -1.218 TD (\025\017\n \230\020\024\030\034 \224\030\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\026\030\001\017\005 \024\030\007\017\027\026\021\024\030 \b\017\ )Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.645 Tw T* [(\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\ \017\016 \(\027\036\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\ \017\017,)6( )]TJ 0.11 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (20 \022\024\036\022\) \235\017\035\017\026\035\026 \2231 \205\206\207\211\ \253\203\204\230\037 \r\t\f\024\022\017\b \n\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.463 Tw T* (\007\017\006\017\027\f\022\017\b \021\036\b\027\024\035\024\020\017\005)Tj /Span<>> BDC ( )Tj EMC [(\227 \006\036\027\021\030\026\035\034\027\t\005 \r\024\036\027\027\t\005\ )6( )]TJ 0.314 Tw T* (\022\035\017\027\017\004\036\f\022\017\005 \020\024\f\023\017\021\026\035\ \034 \017\n\036\027\017 \202.\202.)Tj /Span<>> BDC ( )Tj EMC [(\200\017\001\027\036\r\f\022\024\020\024\273)6( )]TJ 0.686 Tw T* [(\204\017\027\017\f\021\036\030\f\021\r\026 )0.6(\024\002\024\030\024\027\t )0.6(\217\024\f\f\017\005\f\022\024\005 )0.5(\205\036\007\036\030\026\006\017\017;)6( )]TJ 0.279 Tw T* [(ORCID 0009-0004-4515-2275, SPIN-\022\024\007: 5081-5918,)6( )]TJ 0 Tw T* [(A)10(ut)-13(hor ID: 854679)]TJ 0 Tc 0.295 Tw T* [(\204\031\f\026\017\035\024\r )0.5(\200\017\021\026\035\017\005 )0.6(\202\027\026\021\024\035\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 14.231 0 Td [(\227 )0.5(\007.\n.\027., )0.5(\027\026\004\026\035\034)]TJ 0 Tw (-)Tj 0.352 Tw -14.231 -1.218 Td [(\027\017\022 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\024\021\007\036\035\036\027\017\016 \(\f \024\023\036\030\026\006\017\024\ \027\027\t\n\017 )]TJ 0.413 Tw T* (\002\035\024\022\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\006\036\027\021\030\026\035\034\027\024\005 \f\021\036\030\017\035\017\ \026\006\017\024\027\027\024\005\) )0.5(\205\206\207\211 )]TJ 0.307 Tw T* (\253\203\204\230\037 \r\t\f\024\022\017\b \n\036\007\017\006\017\027\f\022\ \017\b \021\036\b\027\024\035\024\020\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \006\036\027)Tj 0 Tw (-)Tj 0.583 Tw T* [(\021\030\026\035\034\027\t\005 \r\024\036\027\027\t\005 \022\035\017\027\ \017\004\036\f\022\017\005 )0.5(\020\024\f\023\017\021\026\035\034 \017\n\036)]TJ 0 Tw (-)Tj 0.782 Tw T* (\027\017 \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\200\017\001\027\036\r\f\022\024\020\024\273 \204\017\027\017\f\021\036\030\ \f\021\r\026 \024\002\024\030\024\027\t )Tj 0.118 Tw T* (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017,\ \023\030\036\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\ \030\t \b\017)Tj 0 Tw (-)Tj 0.062 Tw T* (\030\031\030\020\017\017 \(\f \022\031\030\f\024\n \024\027\022\024\035\024\ \020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\036\r\024\005 \007\017\026\020\027\024\f\021\017\022\017\) \ )Tj 0.024 Tw T* (\235\017\035\017\026\035\026 \235\036\007\036\030\026\035\034\027\024\020\ \024 \020\024\f\031\007\026\030\f\021\r\036\027\027\024\020\024 \002\033\ \007\032\036\021\027\024)Tj 0 Tw (-)Tj 0.115 Tw T* [(\020\024 \r\024\036\027\027\024\020\024 \024\002\030\026\024\r\026\021\036\ \035\034\027\024\020\024 )0.5(\031\004\030\036\032\007\036\027\017\016 )0.5(\r\t\f\001\036\020\024 )]TJ 0.498 Tw T* [(\024\002\030\026\024\r\026\027\017\016 )0.6(\253\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\026\016 )0.6(\026\022\026\007\036\n\017\016 )0.5(\017\n. )]TJ 0.25 Tw T* (\222.\204.)Tj /Span<>> BDC ( )Tj EMC 2.209 0 Td [(\025\017\030\024\r\026\273 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\020. )0.5(\204\024\f\022\r\036; ORCID )0.5(0000-0002-0168-)]TJ 0.637 Tw -2.209 -1.218 Td [(0939, eLIBRAR)-13.9(Y SPIN-\022\024\007: 3379-0023, eLIBRAR)-13.9(Y )]TJ 0 Tw T* [(A)10(ut)-13(hor ID: 856312)]TJ 0.191 Tw T* (\202\002\007\031\030\026\b\n\026\027\024\r \217\017\027\026\021 \205\026\ \030\017\007\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030\001\017\005 )Tj 0.211 Tw T* [(\023\030\036\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\030\ \t )0.5(\(\b\017\030\031\030\020\017\017 \027\036\024\021\035\024\032\027\t\b \f\ \024)]TJ 0 Tw (-)Tj 0.303 Tw T* (\f\021\024\016\027\017\005\) \235\017\035\017\026\035\026 \235\036\007\036\ \030\026\035\034\027\024\020\024 \020\024\f\031\007\026\030\f\021\r\036\027\ \027\024\020\024 )Tj 0.394 Tw T* (\002\033\007\032\036\021\027\024\020\024 \r\024\036\027\027\024\020\024 \ \024\002\030\026\024\r\026\021\036\035\034\027\024\020\024 \031\004\030\ \036\032\007\036)Tj 0 Tw (-)Tj 0.584 Tw T* (\027\017\016 \r\t\f\001\036\020\024 \024\002\030\026\024\r\026\027\017\016\ \253\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\026\016 )Tj 0.435 Tw T* (\026\022\026\007\036\n\017\016 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026\273 \204\017\027\024\002\024\030\024\027\t \217\024\ \f\f\017\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020.)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\036; ORCID 0000-0001-7037-943\216)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Igor Y)35(u. Kim)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-4515-2275)Tj T* [(V)-15(i)-24(t)15(all)35(y A. Musail)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0168-0939)Tj T* [(R)-24(ina)15(t F. A)-13.9(bdur)-33(akhmanov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7037-943\216)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 152.4639 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.224 Tw 8 0 0 8 42.5197 139.6292 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\026\035\026\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \215\026\023\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \221\024\022\n\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002)Tj 0 Tw (-)Tj 0.01 Tc 0.384 Tw -1.296 -1.25 Td [(\b\024\007\017\n\024\f\021\017 )0.5(\023\030\036\024\002\030\026\024\r\026\027\017\016 )0.5(\f\017\f\021\036\n\t )0.5(\n\036\007\017\006\017\027\f\022\024\020\024 )0.5(\024\002\036\f\023\036\004\036)]TJ 0 Tc 0 Tw (-)Tj 0.256 Tw 0 -1.25 TD (\027\017\016 \r\024\005\f\022 \(\f\017\035\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \031\f\035\024\r\017\016\b. )Tj /T1_4 1 Tf 0 Tw (\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 )Tj T* (\255\r\032\025\020\f)Tj /T1_1 1 Tf 0.196 Tw [(. 2024;345\(2\):4\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.52424/00269050_2024_345_2_)Tj T* (4)Tj 0 0 0 1 k /GS1 gs 0.097 Tw [( / K)-16(al)-16(a)-17(chev)]TJ /Span<>> BDC ( )Tj EMC [(O.V., P)39.9(apkov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., T)45(okmakov)]TJ /Span<>> BDC ( )Tj EMC [(M.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. On t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (need )Tj 0.299 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 1.366 0 Td [(tr)-33(ansfor)-15.9(m )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 6.352 0 Td [(medical )0.6(suppor)-22(t )0.5(sy)-12.9(stem )0.5(for )0.6(tr)-32(o)-16(ops )0.6(\(for)-32(ces\) )0.6(in )]TJ 0.159 Tw -7.718 -1.25 Td [(moder)-15(n condi)-24(t)-32(ions. )]TJ /T1_4 1 Tf [(Militar)-42.9(y Medical Jour)-13.9(nal.)]TJ /T1_1 1 Tf ( 2024;345\(2\):4\2268. \(in )Tj 0.023 Tw 29.055 7.5 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.52424/00269050_2024_345_2_4)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.469 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.334 0 Td (\025\026\f\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217., \210\r\004\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \222\026\n\024\b\r\026\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0 Tc 0.034 Tw -1.334 -1.25 Td [(\222\023\036\006\017\026\035\017\017\030\024\r\026\027\027\026\016 )0.5(\b\017\030\031\030\020\017\004\036\f\022\026\016 )0.5(\023\024\n\024\013\034 \r)]TJ /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\n \r\024\036\027)Tj 0 Tw (-)Tj 0.324 Tw T* (\027\024\n \022\024\027\235\035\017\022\021\036: \030\024\035\034 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024\r\t\b \220\021\026\023\026\b \n\036\007\017\006\ \017\027)Tj 0 Tw (-)Tj 0.143 Tw T* (\f\022\024\005 \220\r\026\022\031\026\006\017\017. )Tj /T1_4 1 Tf (\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 \255\ \r\032\025\020\f)Tj /T1_1 1 Tf (. 2024;345\(2\):9\22618. )Tj 0 Tw 27.638 0 Td ( )Tj 0.025 Tc -0.025 Tw -27.638 -1.25 Td [(d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.832 0 Td (10.52424/00269050_2024_345_2_9)Tj 0 0 0 1 k /GS1 gs 0.885 Tw [( / K)-15.7(asimov)]TJ /Span<>> BDC ( )Tj EMC [(R.R.,)25( )]TJ 0 Tc -0.163 Tw -2.832 -1.25 Td [(O)-23.6(vchar)-31.6(ov)]TJ /Span<>> BDC 3.731 0 Td ( )Tj EMC 0.07 0 Td [(O.M., )0.5(Samok)0.5(hv)-14.6(al)30.4(ov)]TJ /Span<>> BDC ( )Tj EMC 7.341 0 Td [(I.M., )0.5(e)-11.5(t)]TJ /Span<>> BDC ( )Tj EMC 2.785 0 Td [(al. )0.5(Spec)-23.5(ial)-30.6(ized )0.5(sur)-31.6(gica)0.5(l )0.5(car)-23.6(e )0.5(in )0.5(mod)]TJ 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (63)Tj ET endstream endobj 1347 0 obj <>/Border[0 0 0]/H/N/Rect[149.71 116.925 263.622 107.469]/Subtype/Link/Type/Annot>> endobj 1348 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 106.925 46.5197 97.6292]/Subtype/Link/Type/Annot>> endobj 1349 0 obj <>/Border[0 0 0]/H/N/Rect[314.069 146.925 431.98 137.629]/Subtype/Link/Type/Annot>> endobj 1350 0 obj <>/Border[0 0 0]/H/N/Rect[297.619 96.9252 421.44 87.6292]/Subtype/Link/Type/Annot>> endobj 1354 0 obj <> endobj 1353 0 obj <> endobj 1352 0 obj <> endobj 1351 0 obj <> endobj 1322 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.121 Tw 10 0 0 10 70.8661 456.9139 Tm (\024\002\255\016\f\027\017\021\034 \026\027\026\021\024\n\024-\021\024\023\ \024\020\030\026\235\017\004\036\f\022\017\n\017 \024\f\024\002\036\027\027\ \024\f\021\016)Tj 0 Tw (-)Tj 0.331 Tw 0 -1.218 TD (\n\017 \030\026\f\023\024\035\024\032\036\027\017\016 \r\027\036\002\030\ \033\001\017\027\027\t\b \024\021\007\036\035\024\r \023\030\016\n\024\005\ )Tj 0.076 Tw T* (\022\017\001\022\017, \007\036\235\017\006\017\021\024\n \024\023\t\021\027\ \t\b \f\023\036\006\017\026\035\017\f\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\022\024-)Tj 0.056 Tw T* (\021\026\022\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\ \024\005. \205\024\030\n\017\030\024\r\026\027\017\036 \024\021\r\024\007\ \016\013\036\005 )Tj 0.131 Tw T* [(\022\024\035\024\f\021\024\n\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.141 0 Td [(\023\036\030\036\007\027\033\033 )0.6(\002\030\033\001\027\031\033 )0.5(\f\021\036\027\022\031 )0.5(\r\t\023\024\035\027\016)]TJ 0 Tw (-)Tj 0.172 Tw -6.141 -1.218 Td (\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (25,9% \004\026\013\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\017\027\027\t\b \030\026\027\036\027\ \017\016\b )Tj 0.034 Tw T* (\(80,6%\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t)Tj 0 Tw (-)Tj T* (\n\017 \217\215\025 \(54,7%\).)Tj 0.115 Tw T* [(\215\030\017 \030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \026\ \027\026\035\017\036 )0.5(\030\036\031\035\034\021\026\021\024\r \b\017\030\031\030\020\017)]TJ 0 Tw (-)Tj -0.036 Tw T* (\004\036\f\022\024\020\024 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M2!8^9 ISf9;Sk4~"!֛6J&N7.G|qpGhijoB{ڞΑW>uiKqD6܄DT`SPyI-4e~̮b:jTWY0Q:Z cÅ&ffy97ДJy4NL'PkiIijNJ5FNcS :)Be)Bj{ŸXeu=ԙm*T}դ)32qtvR$)`ub2"Bd>=R✦R^ʄ%DJJ$\wS3g݊6Ҷ%鲛ZG#<ۧt+I$F[KFD]]2$|qRm 6FCSrڐ#Q`̭R85P8nˊrTK$2=t쮉P$ʚfa;7&Qik$ZRk,9XȨ:E˞#a6v[lX_rUKǟ.dnJa6)3xI 7EA:gFPTk4yv=ͻܹ=R9CDbM)٨tc>^Oj~9]ɴj[&H-ݵ"VF>ɠR%#a BdxRdi%YE+3j7 ;2YmqܪE5D8$ۛc'7ws ,Ji$66jI3Gc2ɪuJTdIddOUԑ&ýkh#)~"Q&~TdwrnMp݇-FjZ)VJR7!M9EmQ1ٙL?`t':"+,ƲF,N 5aYѕҭ{tuӨQ0M)"RKqfEJ;zW8Zrа#&sc)Z^#L="#i/RԄII܄it RBĞRtқ$sRuٲvyjGDdm$B6#3I gw>stream endstream endobj 1355 0 obj <>stream endstream endobj 1318 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 \220\n\005\002\005\013\n\225\ \004\016\r)10(\025\221 \224\025\024\025\234\n )]TJ 0 -1 TD [(\224\005\n\022\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\ \r\n \t\017\022\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 39.559 1 Td [(A dif)-30.9(fer)31(entiated algorithm for pr)20(oviding sur)31(gical car)31(e )]TJ 0.177 -1 Td [(for\022r)31.1(ectal injuries at th)10.9(e\022stages of\022medical e)11(v)10(acuation)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.211 Tw 10 0 0 10 42.5197 615.2279 Tm (\n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\017 \024\023\ \036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\032\017\027\036\027\027\t\n \023\024)Tj 0 Tw (-)Tj 0.354 Tw 0 -1.218 TD (\022\026\026\027\017\016\n. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\024\022\026\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\033 )Tj 0.836 Tw T* (\023\030\036\f\026\022\030\026\035\034\027\024\020\024 \023\030\024\f\021\ \030\026\027\f\021\r\026 \007\024\035\032\027\024 \016\r\035\016\021\034\ \f\016 )Tj 0.722 Tw 0 -1.218 TD (\027\026\035\017\004\017\036 \020\027\024\005\027\024-\027\036\022\030\024\ \021\017\004\036\f\022\017\b \017\n\036\027\036\027\017\005 \025\215\221\ . )Tj 0.147 Tw 0 -1.218 TD (\215\030\036\r\036\027\021\017\r\027\024\036 \007\030\036\027\017\030\024\ \r\026\027\017\036 \025\215\221 \023\024\022\026\026\027\024 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\024\022\017\b \026\n\023\031\035\016\030\027\t\b \030\026\027\036\027\ \017\016\b.)Tj 0.129 Tw T* (\215\030\017 \027\017\022\017\b \030\026\027\036\027\017\016\b \023\030\ \016\n\024\005 \022\017\001\022\017, \007\024\f\021\031\023\027\t\b \r\017\ )Tj 0 Tw (-)Tj 0.256 Tw T* (\031\026\035\034\027\024\n\031 \022\024\027\021\030\024\035\033 \023\024\ \r\030\036\032\007\036\027\017\005, \007\024\f\021\026\021\024\004\027\024\ \r\t)Tj 0 Tw (-)Tj 0.185 Tw T* (\023\024\035\027\036\027\017\016 \023\036\030\r\017\004\027\024\005 \b\017\ \030\031\030\020\017\004\036\f\022\024\005 \024\002\030\026\002\024\021\022\ \017, \004\021\024 )Tj 0.552 Tw 23.244 9.742 Td (\f\024\r\023\026\007\026\036\021 \f)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\024\n )0.5(\027\026\031\004\027\t\b \023\031\002\035\017\022\026\006\017\005 )]TJ 0.049 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\n\036 \017\f\f\035\036\007\024\r\026\027\017\016, \022\026\022 \ \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\031\f\021\017\n\024\f\021\034 \031\001\017\r\026\027\017\016\ )Tj 0.085 Tw T* (\024\007\017\027\024\004\027\t\b \030\026\027 \023\030\016\n\024\005 \022\ \017\001\022\017, \030\026\n\036\030\026\n\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (2,0 \f\n. )Tj 0.143 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 1.996 0 Td [(\n\027\024\032\036\f\021\r\036\027\027\t\b )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.816 0 Td [(\f\022\r\024\027\t\b )0.6(\030\026\027\036\027\017\016\b )0.5(\023\024\022\026\026\027\026 )]TJ 0.034 Tw -9.812 -1.218 Td (\024\002\f\021\030\031\022\021\017\r\027\026\016 \030\036\036\022\006\017\ \016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \024\023\036\030\026\006\017\017 \206\026\030\021\n\026\ \027\026. )Tj 0.067 Tw 0 -1.218 TD (\203\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\036 \f\023\036\006\017\026\035\017\017\030\024\r\026\027\ \027\024\005 \n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\ \017 )Tj 0.061 Tw T* (\021\026\022\032\036 \023\030\017\n\036\027\017\n \023\030\036\007\f\021\ \026\r\035\036\027\027\t\005 \026\035\020\024\030\017\021\n, \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n )Tj 0.12 Tw T* (\017\n\036\033\013\036\005\f\016 \035\026\002\024\030\026\021\024\030\027\ \024-\007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \002\026\t\ , \023\024)Tj 0 Tw (-)Tj 0.265 Tw T* (\r\024\035\016\033\013\017\005 \r\t\023\024\035\027\017\021\034 \022\024\ \030\030\036\022\021\017\030\031\033\013\017\005 \024\002\255\201\n \b\017\ )Tj 0 Tw (-)Tj T* (\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017.)Tj 0.272 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \n\024\032\027\024 \026\022\ \035\033\004\017\021\034, \004\021\024 \f\024\004\036\021\026\027\027\t\005\ )Tj 0.21 Tw T* (\b\026\030\026\022\021\036\030 \024\021\n\036\004\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (89,3%, \r\024 2-\005 )Tj 0.014 Tw T* (\020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (100%. \230\024\035\017\030\024\r\026\027\027\t\005 \b\026\030\026\022\021\ \036\030 \030\026\027\036\027\017\005 )Tj -0.084 Tw T* (\r\f\021\030\036\004\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (10,7% \022\035\017\027\017\004\036\f\022\017\b \027\026\002\035\033\007\036\ \027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031)Tj 0 Tw (-)Tj 0.409 Tw T* (\021\030\017\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\ \b, \022\024\021\024\030\t\036 \023\030\036\r\026\035\017\030\024\r\026\035\ \017 )Tj 0.223 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.973 0 Td [(\f\024\f\021\026\r\017\035\017 )0.6(68,8%. )0.5(\200\027\036\002\030\033\001\017\027\027\t\036 )0.6(\217\215\025 )0.5(\f\024\f\021\026\r\017\035\017 )]TJ 0.161 Tw -0.973 -1.218 Td [(31,2%. \210\006\036\027\022\026 \023\024\035\031\004\036\027\027\t\b )0.5(\030\036\031\035\034\021\026\021\024\r \023\024\022\026\t\r\026\036\021\ , )]TJ -0.043 Tw T* (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \027\026\004\017\n\024 \023\ \030\036\r\026\035\017\030\024\r\026\035\017 \024\f\022\024\035\024\004)Tj 0 Tw (-)Tj 0.067 Tw T* (\027\t\036 \030\026\027\036\027\017\016. \221\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036 \024\027\017 \f\024\f\021\026\r\017\035\017\ 79,6% )Tj -0.038 Tw T* (\f\035\031\004\026\036\r, \023\030\036\r\026\035\017\030\024\r\026\035\017\ \027\026\007 \023\031\035\036\r\t\n\017 \(16,1%\) \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027)Tj 0 Tw (-)Tj 0.044 Tw T* (\027\024-\r\030\t\r\027\t\n\017 \(4,3%\). \200\024 2-\005 \020\030\031\023\ \023\036 \021\026\022\032\036 \023\030\036\024\002\035\026)Tj 0 Tw (-)Tj 0.205 Tw T* (\007\026\035\017 \024\020\027\036\f\021\030\036\035\034\027\t\036 \024\f\ \022\024\035\024\004\027\t\036 \030\026\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 71,5% )Tj -0.007 Tw T* (\f\035\031\004\026\036\r \023\030\024\021\017\r \023\031\035\036\r\t\b \(\ 4,7%\). \203\026\017\002\024\035\036\036 \004\026\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\036\n \r\027\031\021\030\017\002\030\033\001\017\ \027\027\024\020\024 \024\021\007\036\035\026 \023\030\016)Tj 0 Tw (-)Tj 0.061 Tw T* [(\n\024\005 )0.5(\022\017\001\022\017 )0.6(\024\021\n\036\004\036\027\024 )0.5(\023\024\r\030\036\032\007\036\027\017\036 )0.6(\n\024\004\036\r\024\020\024 )0.5(\023\031\t\030\016, )]TJ 0.076 Tw T* [(\023\030\024\f\021\026\021\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\031\030\036\021\030\t)Tj /Span<>> BDC ( )Tj EMC [(\227 )0.5(32,2% \f\035\031\004\026\036\r, )0.5(\n\026\020\017\f\021\030\026\035\034\027\t\b )]TJ 0.176 Tw T* (\f\024\f\031\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 28%, \022\024\f\021\036\005 \021\026\026)Tj /Span<>> BDC ( )Tj EMC (\227 25,8%. \230)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r )Tj 0.347 Tw T* (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \027\026\017\002\ \024\035\036\036 \004\026\f\021\024 \026\235\017\022\f\017\030\024\r\026\ \027\024 )Tj 0.069 Tw T* (\030\026\027\036\027\017\036 \021\024\027\022\024\005 \022\017\001\022\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 22,6% \f\035\031\004\026\036\r, \024\002\024\007\024\004\027\024\005\ )Tj 0.116 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 19,3% \027\026\002\035\033\007\036\027\017\005. \221\026\022\032\036\ \r)Tj /Span<>> BDC ( )Tj EMC (7,5% \f\035\031\004\026\036\r )Tj 0.07 Tw T* (\024\021\n\036\004\036\027\024 \023\024\r\030\036\032\007\036\027\017\036\ \032\036\035\031\007\022\026, \026)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (3,2%)Tj /Span<>> BDC ( )Tj EMC (\227 \020\036\023\026\021\024)Tj 0 Tw (-)Tj 0.206 Tw T* (\002\017\035\017\026\030\027\024\005 \024\027\t. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\027\036\002\030\033\001\017\027\027\024\005 )0.5(\035\024\022\026\035\017\026\006\017\017, )]TJ 0.355 Tw T* [(\027\026\017\002\024\035\036\036 \004\026\f\021\024 \r\f\021\030\036\004\ \026\035\017 )0.5(\023\024\r\030\036\032\007\036\027\017\016 \n\024\004\036\r\024\020\024 \ )]TJ 0.2 Tw T* (\023\031\t\030\016, \031\030\036\021\030\t)Tj /Span<>> BDC ( )Tj EMC (\227 30,9% \022\035\017\027\017\004\036\f\022\017\b \f\035\031\004\026\036\ \r, \022\024)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\f\021\036\005 \021\026\026)Tj /Span<>> BDC ( )Tj EMC (\227 28,6%, \n\026\020\017\f\021\030\026\035\034\027\t\b \f\024\f\031\007\ \024\r)Tj /Span<>> BDC ( )Tj EMC (\227 23,8%. )Tj 0.152 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\005 \f\021\036\023\036\027\017 \017\n\036\035\017\ \n\036\f\021\024 \023\024\r\030\036\032\007\036\027\017\016 \024\002\024\ )Tj 0 Tw (-)Tj 0.198 Tw 0 -1.218 TD (\007\024\004\027\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 4,3% \027\026\002\035\033\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\027\022\024\005 \022\017\001)Tj 0 Tw (-)Tj T* (\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 9,5% \f\035\031\004\026\036\r.)Tj 0.05 Tw T* (\215\030\017 \026\027\026\035\017\036 \030\036\031\035\034\021\026\021\ \024\r \017\031\004\036\027\017\016 \024\002\255\201\n\026 \024\023\036\ \030\026\006\017\005 )Tj 0.283 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\016\b \023\030\016\n\024\005 \022\017\001\022\017\ \n\024\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 )Tj -0.016 Tw T* (\031\001\017\r\026\027\017\036 \030\026\027 \023\030\017\n\036\027\016\035\ \024\f\034 \023\030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\024\n \022\024\035\017)Tj 0 Tw (-)Tj -0.03 Tw T* (\004\036\f\021\r\036 \(\r 1-\005 \020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 30,2%, \r\024 2-\005 \020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 28,5%, )Tj 0.081 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024\). \217\036\036\022\006\ \017\016 \023\030\016\n\024\005 \022\017\001\022\017 \002\t\035\026 \023\ \030\017)Tj 0 Tw (-)Tj 0.054 Tw T* (\n\036\027\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (57,9% \004\026\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036 \(69,8%\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj -0.037 Tw T* (\027\036\027\017\033 \f\024 2-\005 \020\030\031\023\023\024\005 \(11,9%\)\ , \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.037 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05,)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf -0.037 Tw 17.825 0 Td (\004\021\024 \n\024\032\027\024 )Tj ET q /GS0 gs 221.1023475 0 0 112.3516816 42.5196833 389.1611042 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 378.3611 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \f\020\240\031\032\020\023\031\032\025\013\ \200 \033\031\n\020\016\020\023\027\f\027\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Dynamics of)Tj /Span<>> BDC ( )Tj EMC [(laborator)-42.8(y parameters)]TJ ET q /GS0 gs 221.1023475 0 0 109.7109404 42.5196833 247.3462378 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 236.5462 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \205-\032\027\020\n\023\022\021\025\031\b\ \031 \240\027\f\n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Dynamics of)Tj /Span<>> BDC ( )Tj EMC [(C-reactiv)13.2(e p)46(ro)13(tein)]TJ ET q /GS0 gs 221.1023475 0 0 114.2722228 42.5196833 100.9700975 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \031\006\027\025\n\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\211\003\237 \240\031\f\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)21(esults of)]TJ /Span<>> BDC ( )Tj EMC [(the visual analog scale assess)33.3(ment of)]TJ /Span<>> BDC ( )Tj EMC (pain)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \031\024\f\031\255\ \025\027\025\022\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.076 Tc 0.076 Tw 0 -1.2 TD [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.25 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-4.9(li)-1.8(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 235.5256 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 703.7117 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 703.7117 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 703.7117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 692.2505 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 692.2505 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 692.2505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 680.7892 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 680.7892 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 680.7892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 669.3279 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 669.3279 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 669.3279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 657.8666 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 657.8666 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 657.8666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.4053 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 235.5256 646.4053 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 646.4053 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 439.6201 646.4053 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 117.3998 706.5463 Tm (\017\217\f\002\202\b\r\b\t\r)Tj 17.188 0 Td (\017\217\b\002\b\004\235 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15\))Tj 12.489 0 Td (\255\006\004\b\r\b\t\235 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (24\))Tj /T1_4 1 Tf 13.884 0.001 Td (p)Tj /T1_1 1 Tf -52.536 -1.433 Td (\200\027\031\021\030\017\002\030\033\001\027\024\005 \026\002\f\006\036\f\ \f)Tj 29.146 0 Td (6,6%)Tj 12.506 0 Td (12,6%)Tj 10.301 0 Td (0,56)Tj -51.953 -1.433 Td (\210\f\021\030\026\016 \022\017\001\036\004\027\026\016 \007\017\027\026\ \n\017\004\036\f\022\026\016 \027\036\023\030\024\b\024\007\017\n\024\f\021\ \034)Tj 28.896 0 Td (13,4%)Tj 13.006 0 Td (4,2%)Tj 10.051 0 Td (0,74)Tj -51.953 -1.433 Td (\206\027\024\005\027\t\036 \026\002\f\006\036\f\f\t \017)Tj /Span<>> BDC ( )Tj EMC (\235\035\036\020\n\024\027\t \021\026\026)Tj 29.489 0 Td (0%)Tj 12.163 0 Td (33,3%)Tj 10.051 0 Td (0,001)Tj -51.703 -1.433 Td (\202\027\026\220\030\024\002\027\026\016 \027\036\022\035\024\f\021\030\017\ \007\017\026\035\034\027\026\016 \017\027\235\036\022\006\017\016)Tj 29.146 0 Td (6,6%)Tj 13.135 0 Td (8,3)Tj 9.671 0 Td (0,76)Tj -51.953 -1.433 Td (\210\020\027\036\f\021\030\036\035\034\027\t\005 \023\036\030\017\021\024\ \027\017\021*)Tj 28.896 0 Td (73,4%)Tj 13.135 0 Td (41,6)Tj 9.921 0 Td (0,62)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.002 56.0378 Tm (61)Tj ET endstream endobj 1319 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   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T* [(\210\002\255\201\n )0.5(\024\022\026\026\027\017\016 )0.5(\f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\024\005 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\005 )]TJ T* [(\023\024\n\024\013\017 )0.5(\026\022\035\033\004\026\035\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.307 0 Td [(\r\t\023\024\035\027\036\027\017\017 )0.6(\023\024\r\021\024\030\027\t\b )0.5(\024\023\036\030\026)]TJ 0 Tw (-)Tj 0.011 Tw -9.307 -1.218 Td (\021\017\r\027\t\b \r\n\036\001\026\021\036\035\034\f\021\r, \027\026\023\ \030\026\r\035\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\030\034\002\031 \f)Tj /Span<>> BDC ( )Tj EMC (\031\032\036 )Tj 0.367 Tw 0 -1.218 TD (\030\026\r\017\r\001\017\n\017\f\016 \024\f\035\024\032\027\036\027\017\ \016\n\017, \017\f\023\030\026\r\035\036\027\017\036\n \024\001\017)Tj 0 Tw (-)Tj 0.122 Tw 0 -1.218 TD (\002\024\022 \023\030\036\007\t\007\031\013\017\b \220\021\026\023\024\r\ \017)Tj /Span<>> BDC ( )Tj EMC 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( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\017\027\027\t\b \030\026\027\036\027\ \017\016\b \021\026\022\032\036 \r\t)Tj 0 Tw (-)Tj 0.083 Tw 0 -1.218 TD [(\023\024\035\027\016\035\017 )0.6(\024\002\f\021\030\031\022\021\017\r\027\031\033 )0.5(\030\036\036\022\006\017\033 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 15.974 0 Td [(\021\017\023\031 )0.5(\024\023\036\030\026\006\017\017 )]TJ 0.094 Tw -15.974 -1.218 Td (\206\026\030\021\n\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034\033 \030\026\ \027\036\036 \027\026\035\024)Tj 0 Tw (-)Tj 0.075 Tw 0 -1.218 TD (\032\036\027\027\t\b \001\r\024\r. \217\036\022\024\027\f\021\030\031\022\ \006\017\016 \022\024\035\024\f\021\024\n\t \023\024\021\030\036\002\024\ \r\026)Tj 0 Tw (-)Tj 0.129 Tw T* (\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (29% \027\026\002\035\033\007\036\027\017\005, \004\021\024 \002\t\035\024\ \f\r\016\026\027\024 \f)Tj 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)0.5(\202\027\026\220\030\024\002\027\026\016 )0.6(\027\036\022\035\024\f\021\030\017\007\017\026\035\034\027\026\016 )0.6(\017\027\235\036\022)]TJ 0 Tw (-)Tj 0.162 Tw T* (\006\017\016 \007\017\026\020\027\024\f\021\017\030\024\r\026\027\026 \r\ )Tj /Span<>> BDC ( )Tj EMC (6,6% \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \024\f\027\024\r\027\024\005 )Tj 0.152 Tw T* (\020\030\031\023\023\t, \017)Tj /Span<>> BDC ( )Tj EMC (\r 8,3%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016. \215\026\006\017\ \036\027\021\t )Tj 0.349 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n\017 )0.5(\024\f\035\024\032\027\036\027\017\016\n\017 )0.5(\023\024\020\017\002\035\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\235\024\027\036 \023\030\024)Tj 0 Tw (-)Tj 0.31 Tw T* (\020\030\036\f\f\017\030\031\033\013\036\005 \023\024\035\017\024\030\020\ \026\027\027\024\005 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\f\024\024\021\r\036\021\f\021\r\036\027\027\024,)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (41,6%.)Tj 0.141 Tw T* (\221\026\022\032\036 \024\021\n\036\004\036\027\t \030\026\027\t\036 \f\ \030\024\022\017 \030\026\r\017\021\017\016 \020\027\024\005\027\024-\027\ \036)Tj 0 Tw (-)Tj 0.122 Tw T* (\022\030\024\021\017\004\036\f\022\017\b \017\n\036\027\036\027\017\005\ \025\215\221 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\n \002\017\035\026)Tj 0 Tw (-)Tj 0.223 Tw T* (\021\036\030\026\035\034\027\024\n \023\026\030\026\030\036\022\021\026\035\ \034\027\024\n \007\030\036\027\017\030\024\r\026\027\017\017 \(\217\017\ \f.)Tj /Span<>> BDC ( )Tj EMC (5\). )Tj 0.101 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \n\036\021\024\007\017\022\ \017 \026\022\021\017\r\027\024\020\024 \007\030\036\027\017\030\024\r\026\ )Tj 0 Tw (-)Tj 0.21 Tw T* (\027\017\016 \023\030\036\f\026\022\030\026\035\034\027\024\020\024 \023\ \030\024\f\021\030\026\027\f\021\r\026, \020\027\024\005\027\024-\027\036\ \022\030\024\021\017)Tj 0 Tw (-)Tj 0.063 Tw T* (\004\036\f\022\017\036 \017\n\036\027\036\027\017\016 \025\215\221 \024\ \021\n\036\004\036\027\t \027\036 \002\t\035\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027)Tj 0 Tw (-)Tj 0.601 Tw T* (\007\026\030\021\027\024\n \002\017\035\026\021\036\030\026\035\034\027\024\ \n \007\030\036\027\017\030\024\r\026\027\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (12,5% )Tj 0.373 Tw T* [(\f\035\031\004\026\036\r )0.5(\031\022\026\026\027\027\t\036 )0.6(\024\f\035\024\032\027\036\027\017\016 )0.6(\026\030\036\020\017\f\021\030\017\030\024\r\026\027\t )]TJ 0.089 Tw 23.244 8.525 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (2-\036 \f\031\021\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (65,2%)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (3-\036 \f\031\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036. \203\036 \024\021)Tj 0 Tw (-)Tj 0.184 Tw T* [(\n\036\004\036\027\024 )0.5(\030\026\r\017\021\017\036 )0.6(\024\f\035\024\032\027\036\027\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.97 0 Td [(25,0% )0.5(\022\035\017\027\017\004\036\f\022\017\b )]TJ 0 Tw -13.97 -1.218 Td (\027\026\002\035\033\007\036\027\017\005.)Tj 0.508 Tw T* (\222 \031\004\201\021\024\n \023\024\035\031\004\036\027\027\t\b \030\036\ \031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\r\026\027\017\016\ , )Tj 0.28 Tw T* [(\002\t\035 \030\026\030\026\002\024\021\026\027 \026\035\020\024\030\017\ \021\n \024\022\026\026\027\017\016 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\005 )]TJ 0.072 Tw T* (\023\024\n\024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\). \222)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \023\024\035\031\004\036\027)Tj 0 Tw (-)Tj 0.411 Tw T* (\027\t\b \030\036\031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\ \r\026\027\017\005, \f\004\017\021\026\036\n \006\036\035\036\f\024\024)Tj 0 Tw (-)Tj 0.183 Tw T* (\002\030\026\027\t\n \r\t\023\024\035\027\036\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\036 \022\r\026\035\017\235\017\006\017\030\024\r\026\027\ \027\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.146 Tw 9 0 0 9 303.3071 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \024\031\007\027\023\ \020\025\025\031\024\023\022 \032\020\025\027\025\022\235 \033\032\t)Tj 0 Tw (-)Tj 0 -1.2 TD (\026\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)2(b)-1.1(i)4(n)-2.4(e)-12.9(d r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l i)4(n)3.7(j)2.4(u)1.6(r)-39(i)-1.4(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 704.381 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 704.381 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 704.381 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.3071 683.3118 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 683.3118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 683.3118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 672.1005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 671.8505 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 671.8505 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 671.8505 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 660.6392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 660.3892 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 660.3892 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 660.3892 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 649.1779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 648.9279 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 637.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 648.9279 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 637.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 648.9279 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 637.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 637.7166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 637.4666 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 626.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 637.4666 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 626.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 637.4666 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 626.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 626.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 626.0054 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 614.7941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 626.0054 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 614.7941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 626.0054 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 614.7941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 614.7941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 614.5441 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 303.5571 603.3328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 614.5441 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 428.2815 603.3328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 614.5441 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 603.3328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 603.3328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 603.0828 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 428.2815 603.0828 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 476.4705 603.0828 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 339.8236 690.9464 Tm (\017\006\n\004\b, \217\t\217\003\r\214\004 )Tj 11.749 0.6 Td (1-\235 \n\006\210\212\212\004 )Tj 0.55 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (93\))Tj 5.474 1.2 Td (2-\235 \n\006\210\212\212\004 )Tj 0.55 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (42\))Tj /T1_0 1 Tf -22.502 -1.433 Td (\204\024\004\036\r\024\005 \023\031\t\030\034, \023\030\024\f\021\026\021\ \026, \031\030\036\021\030\026)Tj 17.026 0 Td (32,2%)Tj 6.024 0 Td (30,9%)Tj -23.05 -1.433 Td (\222\024\f\031\007\t)Tj 17.369 0 Td (28%)Tj 5.681 0 Td (23,8%)Tj -23.05 -1.433 Td (\025\024\f\021\017 \021\026\026)Tj 17.026 0 Td (25,8%)Tj 6.024 0 Td (28,6%)Tj -23.05 -1.433 Td (\221\024\027\022\026\016 \022\017\001\022\026)Tj 17.026 0 Td (22,6%)Tj 6.274 0 Td (9,5%)Tj -23.3 -1.433 Td (\210\002\024\007\024\004\027\026\016 \022\017\001\022\026)Tj 17.026 0 Td (19,3%)Tj 6.274 0 Td (4,3%)Tj -23.3 -1.433 Td (\240\036\035\031\007\024\022)Tj 17.276 0 Td (7,5%)Tj 6.366 0 Td (0%)Tj -23.642 -1.433 Td (\206\036\023\026\021\024\002\017\035\017\026\030\027\026\016 \024\027\026\ )Tj 17.276 0 Td (3,2%)Tj 6.366 0 Td (0%)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.064 Tw 9 0 0 9 303.3071 586.3635 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\240\236\027\026 \031\033\027\032\020\006\022\235 \025\020 \204\023\ \020\033\027 \n\021\020\f\022\203\022\006\022\032\031\021\020\025\025\031\ \235 )Tj 0 Tw T* (\026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.06 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.033 Tw 3.357 0 Td [( S)0.7(c)2.8(o)-5.3(p)-11.3(e o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-9.1(t t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-2(a)-5.2(g)-6.8(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(q)-3(ua)-4.5(li)6.4(\243)-0.7(e)-12.9(d m)-5.3(e)-12.9(d)-3(i)-1.7(c)3.2(a)-4.5(l )]TJ -0.003 Tc 0.003 Tw -3.357 -1.2 Td [(ca)-7.2(r)-5(e)]TJ ET /GS2 gs q 1 0 0 1 303.3071 549.4615 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 303.5571 528.6423 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 388.5964 549.4615 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 388.5964 528.6423 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 549.4615 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 528.6423 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 490.6437 549.4615 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 528.6423 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 528.6423 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.3071 528.3923 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 303.5571 440.381 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 388.5964 528.3923 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 388.5964 440.381 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 439.6201 528.3923 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 440.381 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 490.6437 528.3923 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 440.381 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 524.6594 440.381 cm 0 0 m 0 87.761 l S Q q 1 0 0 1 303.3071 440.131 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 303.5571 428.9198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5964 440.131 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 388.5964 428.9198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 440.131 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 428.9198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 440.131 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 428.9198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 428.9198 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 428.6698 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 303.5571 417.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5964 428.6698 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 388.5964 417.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 428.6698 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 417.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 428.6698 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 417.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 417.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 417.2085 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 303.5571 405.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5964 417.2085 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 388.5964 405.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 417.2085 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 405.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 417.2085 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 405.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 405.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 405.7472 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 303.5571 394.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5964 405.7472 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 388.5964 394.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 405.7472 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 394.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 405.7472 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 394.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 394.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 394.2859 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 388.5964 394.2859 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 439.6201 394.2859 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 490.6437 394.2859 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 331.7448 536.027 Tm (\231\f\r\214\r\b\003)Tj 7.975 0.6 Td (1-\235 \n\006\210\212\212\004 )Tj 0.55 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (93\))Tj 5.828 1.2 Td (2-\235 \n\006\210\212\212\004 )Tj 0.55 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (42\))Tj /T1_3 1 Tf 6.825 0.6 Td (p)Tj /T1_0 1 Tf -24.898 -2.033 Td (\025\024\035\017\004\036\f\021\r\024 )Tj T* (\r\024\r\035\036\004\201\027\027\t\b \024\030\020\026\027\024\r)Tj 1.063 -1.2 Td (0)Tj T* (1)Tj T* (2)Tj T* (3)Tj T* (4)Tj T* (5)Tj T* (6)Tj 11.18 7.2 Td (10,7%)Tj T* (15,0%)Tj 0.25 -1.2 Td (7,5%)Tj -0.25 -1.2 Td (18,3%)Tj T* (26,9%)Tj 0.25 -1.2 Td (9,8%)Tj -0.25 -1.2 Td (11,8%)Tj 6.378 7.2 Td (20,0%)Tj T* (40,5%)Tj 0.25 -1.2 Td (8,6%)Tj T* (7,1%)Tj -0.25 -1.2 Td (23,8%)Tj 0.592 -1.2 Td (0%)Tj T* (0%)Tj 5.102 7.2 Td (0,65)Tj T* (0,78)Tj T* (0,52)Tj T* (0,71)Tj T* (0,82)Tj T* (0,89)Tj T* (0,25)Tj -24.315 -1.433 Td (\211\001\017\r\026\027\017\036 \030\026\027\t)Tj 12.243 0 Td (30,2%)Tj 6.378 0 Td (28,5%)Tj 5.694 0 Td (0,65)Tj -24.315 -1.433 Td (\217\036\036\022\006\017\016 \022\017\001\022\017)Tj 12.243 0 Td (69,8%)Tj 6.378 0 Td (11,9%)Tj 5.444 0 Td (0,001)Tj -24.065 -1.433 Td (\025\024\035\024\f\021\024\n\017\016)Tj 12.243 0 Td (80,6%)Tj 6.378 0 Td (54,7%)Tj 5.694 0 Td (0,86)Tj -24.315 -1.433 Td (\212\030\036\027\017\030\024\r\026\027\017\036 \025\215\221)Tj 12.835 0 Td (0%)Tj 5.785 0 Td (80,9%)Tj 5.444 0 Td (0,001)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.664 Tw 9 0 0 9 303.3071 377.5667 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\023\032\r\n\023\r\032\020 \031\033\027\032\020\023\022\021\025\013\ \200 \021\026\027\213\020\023\027\f\017\024\023\021 )Tj 0 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC (\204\023\020\033\027 \024\033\027\006\022\020\f\022\016\022\032\031\021\020\ \025\025\031\235 \200\022\032\r\032\b\022\007\027\024\n\031\235 \033\031\ \026\031\212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.005 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.4(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.022 Tw 3.307 0 Td [( S)11.6(t)-9.6(r)-9.1(u)-3.7(c)-32.4(t)-1.1(u)1.6(r)-2(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)6.7(u)1.6(r)-2(g)-18.7(i)-1.8(c)3.2(a)-4.5(l i)3.9(n)-0.6(t)-1.6(e)-6(r)-42.8(v)2.3(e)-7(n)-0.6(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-9.2(t t)-10.5(h)-2.5(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-2(a)-5.2(g)-6.8(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)4.4(p)-11.3(e)]TJ 0 Tw 20.964 0 Td (-)Tj -24.271 -1.2 Td [(c)-30.1(i)1.5(a)-4.5(li)8(z)7.9(e)-12.9(d s)6.7(u)1.6(r)-2(g)-18.7(i)-1.8(c)3.2(a)-4.4(l c)3.2(a)-4.2(r)-2(e)]TJ ET /GS2 gs q 1 0 0 1 303.3071 340.6647 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 319.8455 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 340.6647 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 319.8455 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 482.1397 340.6647 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 319.8455 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 319.8455 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.3071 319.5955 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 308.3842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 319.5955 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 308.3842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 319.5955 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 308.3842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 308.3842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 308.1342 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 296.9229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 308.1342 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 296.9229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 308.1342 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 296.9229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 296.9229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 296.6729 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 285.4616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 296.6729 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 285.4616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 296.6729 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 285.4616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 285.4616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 285.2116 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 264.4004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 285.2116 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 264.4004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 482.1397 285.2116 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 264.4004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 264.4004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 303.3071 264.1504 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 252.9391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 264.1504 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 252.9391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 264.1504 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 252.9391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 252.9391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 252.6891 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 241.4778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 252.6891 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 241.4778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 252.6891 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 241.4778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 241.4778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 241.2278 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 230.0165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 241.2278 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 230.0165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 241.2278 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 230.0165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 230.0165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 229.7665 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 303.5571 218.5552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 229.7665 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 439.6201 218.5552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 482.1397 229.7665 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 482.1397 218.5552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 218.5552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.3071 218.3052 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 439.6201 218.3052 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 482.1397 218.3052 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 326.829 327.2301 Tm (\025\004\t\214\r\b\002\004\b\t\r \002\212\r\006\004\204\t\t,)Tj -0.034 Tw 14.453 0.6 Td (1-\235 \n\006\210\212\212\004 )Tj 0 Tw 0.533 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (93\))Tj -0.034 Tw 4.782 1.2 Td (2-\235 \n\006\210\212\212\004 )Tj 0 Tw 0.533 -1.2 Td (\()Tj /T1_3 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (42\))Tj /T1_0 1 Tf -22.856 -1.433 Td (\211\001\017\r\026\027\017\036 \030\026\027\t \023\030\016\n\024\005 \022\ \017\001\022\017)Tj 18.089 0 Td (11,8%)Tj 5.907 0 Td (0%)Tj -23.996 -1.433 Td (\217\036\036\022\006\017\016 \023\030\016\n\024\005 \022\017\001\022\017\ )Tj 18.089 0 Td (21,5%)Tj 5.315 0 Td (35,7%)Tj -23.404 -1.433 Td (\217\036\022\024\027\f\021\030\031\022\006\017\016 \022\024\035\024\f\021\ \024\n\t)Tj 18.432 0 Td (29%)Tj 5.565 0 Td (0%)Tj -23.996 -1.433 Td (\202\022\021\017\r\027\024\036 \007\030\036\027\017\030\024\r\026\027\017\ \036 )Tj T* (\023\030\036\f\026\022\030\026\035\034\027\024\020\024 \023\030\024\f\021\ \030\026\027\f\021\r\026)Tj 4.664 0 0 4.664 405.3906 269.649 Tm (*)Tj 8 0 0 8 455.844 276.585 Tm (0%)Tj 4.722 0 Td (35,7%)Tj -23.404 -2.633 Td (\222\026\027\026\006\017\024\027\027\026\016 \030\036\035\026\023\026\030\ \024\021\024\n\017\016)Tj 18.089 0 Td (46,2%)Tj 5.315 0 Td (54,7%)Tj -23.404 -1.433 Td (\203\026\024\020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\ \034\027\026\016 \017\027\021\031\002\026\006\017\016)Tj 18.089 0 Td (40,8%)Tj 5.315 0 Td (23,8%)Tj -23.404 -1.433 Td (\211\001\017\r\026\027\017\036 \030\026\027 \n\024\004\036\r\024\020\024\ \023\031\t\030\016)Tj 18.682 0 Td (0%)Tj 4.972 0 Td (9,5%)Tj -23.654 -1.433 Td (\215\030\024\004\017\036 \024\023\036\030\026\006\017\017)Tj 18.089 0 Td (36,5%)Tj 5.315 0 Td (33,3%)Tj /T1_2 1 Tf 7 0 0 7 303.3071 206.8206 Tm (\004\032\022\026\027\007\020\025\022\027: *)Tj /Span<>> BDC ( )Tj EMC 6.469 0 Td [(\004\020)49(\023\027\025\023 \206\214 \2422845987 \253\205\033\031\024\031\240 \020\n\ \023\022\021\025\031\b\031 \030)26.3(\032\027\025\022\032\031\021\020\025\022\t )]TJ -6.469 -1.2 Td (\033\032\027\024\020\n\032\020\f\017\025\031\b\031 \033\032\031\024\023\032\ \020\025\024\023\021\020 \033\032\022)Tj /Span<>> BDC ( )Tj EMC [(\032\020\025\027\025\022\t\200 \021\025\027\240\032\005\213\022\025\025\013\ \200 \031\023)16.5(\030\027\f\031\021 )]TJ T* (\033\032\t\026\031\235 \n\022\213\n\022\273.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.115 56.0378 Tm (60)Tj ET endstream endobj 1365 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 \220\n\005\002\005\013\n\225\ \004\016\r)10(\025\221 \224\025\024\025\234\n )]TJ 0 -1 TD [(\224\005\n\022\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\ \r\n \t\017\022\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 39.559 1 Td [(A dif)-30.9(fer)31(entiated algorithm for pr)20(oviding sur)31(gical car)31(e )]TJ 0.177 -1 Td [(for\022r)31.1(ectal injuries at th)10.9(e\022stages of\022medical e)11(v)10(acuation)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.007 Tw 10 0 0 10 42.5197 456.9139 Tm (\r)Tj /Span<>> BDC ( )Tj EMC (99,2%)Tj /Span<>> BDC ( )Tj EMC (\227 \n\031\032\f\022\024\005, \r)Tj /Span<>> BDC ( )Tj EMC (0,8%)Tj /Span<>> BDC ( )Tj EMC (\227 \032\036\027\f\022\017\005, \004\021\024 \024\002\255\016\f\027\016\ )Tj 0 Tw (-)Tj 0.175 Tw 0 -1.218 TD [(\036\021\f\016 \024\f\024\002\036\027\027\024\f\021\016\n\017 )0.5(\r\024\036\027\027\024\005 \f\035\031\032\002\t, \r\t\023\024\035\027\036\ \027\017\036\n )]TJ 0 Tw T* (\002\024\036\r\t\b \026\007\026\004 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\027\026\027\026\004\036\027\017\033.)Tj -0.043 Tw T* (\222 \031\004\201\021\024\n \r\030\t\r\027\t\b \b\026\030\026\022\021\036\ \030\017\f\021\017\022 \f\024\r\030\036\n\036\027\027\t\b \030\026\027\016\ )Tj 0 Tw (-)Tj 0.171 Tw T* (\013\017\b \f\027\026\030\016\007\024\r, \026\027\026\021\024\n\024-\021\ \024\023\024\020\030\026\235\017\004\036\f\022\017\b \024\f\024\002\036\027\ \027\024)Tj 0 Tw (-)Tj -0.038 Tw T* (\f\021\036\005 \032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\026, \r)Tj /Span<>> BDC ( )Tj EMC (\026\002\f\024\035\033\021\027\024\n \002\024\035\034\001\017\027\f\021\r\ \036 \f\035\031\004\026)Tj 0 Tw (-)Tj 0.079 Tw T* (\036\r \217\215\025 \017\n\036\035\017 \f\024\004\036\021\026\027\027\t\005\ \b\026\030\026\022\021\036\030 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\). \221\026\022\017\n )Tj 0.419 Tw T* (\024\002\030\026\024\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\017\027\027\t\b \217\215\025 \f\024\ \004\036\021\026\027\027\t\005 )Tj 0.043 Tw T* (\b\026\030\026\022\021\036\030 \023\024\r\030\036\032\007\036\027\017\005\ \r\f\021\030\036\004\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (89,3% \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj 0.064 Tw T* (\027\017\005, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (100%. \230\024\035\017\030\024\r\026\027\027\t\005 )Tj 0.632 Tw T* (\b\026\030\026\022\021\036\030 \217\215\025 \027\026\002\035\033\007\026\ \035\f\016 \021\024\035\034\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017)Tj 0 Tw (-)Tj 0.464 Tw T* (\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\b, \f\024\f\ \021\026\r\017\035 10,7%. \222\r\036\007\036\027\017\016 )Tj -0.02 Tw 23.244 13.396 Td (\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\027\024\f\021\017 \030\026\027\036\027\017\005\ \023\030\016\n\024\005 \022\017\001\022\017 \023\030\036\007\f\021\026\r\ \035\036\027\t )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 4.)Tj 0.125 Tw T* [(\203\026 \220\021\026\023\036 \022\r\026\035\017\235\017\006\017\030\024\ \r\026\027\027\024\005 )0.5(\n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\017 )]TJ 0.148 Tw T* (\024\002\255\201\n \b\017\030\031\030\020\017\004\036\f\022\024\005 \023\ \024\n\024\013\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\) \026\022\035\033\004\026\035\f\016 )Tj 0.204 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.91 0 Td [(\r\t\023\024\035\027\036\027\017\017 )0.6(\024\023\036\030\026\006\017\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 11.378 0 Td [(\027\036\024\021\035\024\032\027\t\n )0.6(\023\024\022\026\026\027\017)]TJ 0 Tw (-)Tj 0.049 Tw -12.289 -1.218 Td (\016\n \(\023\030\024\007\024\035\032\026\033\013\036\036\f\016 \r\027\031\ \021\030\017\002\030\033\001\027\024\036 \022\030\024\r\024\021\036\004\036\ \027\017\036, )Tj 0.019 Tw T* (\220\r\036\027\021\030\026\006\017\016 \r\027\031\021\030\036\027\027\017\ \b \024\030\020\026\027\024\r, \023\024\r\030\036\032\007\036\027\017\036\ \023\024\035\t\b )Tj 0.422 Tw T* [(\024\030\020\026\027\024\r\). \211\001\017\r\026\027\017\036 \217\215\025\ \r\t\023\024\035\027\016\035\017 )0.5(\023\030\026\022\021\017\004\036\f\022\017 )]TJ 0.067 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\t\b \f\024\024\021\027\024\001\036\027\017\016\b \(28,5 \r\ )Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036, 30,2%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.249 Tw T* (\r\024 2-\005 \020\030\031\023\023\036\). \217\036\036\022\006\017\016 \ \023\030\016\n\024\005 \022\017\001\022\017 \r\t\023\024\035\027\016)Tj 0 Tw (-)Tj 0.21 Tw T* [(\035\026\f\034 )0.5(\004\026\013\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 6.74 0 Td [(\r\027\031\021\030\017\002\030\033\001\017\027\027\t\b )0.5(\030\026\027\036\027\017\016\b )0.6(\(69,8% )]TJ 0.15 Tw -6.74 -1.218 Td (\f\035\031\004\026\036\r \023\030\024\021\017\r 11,9%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\b \217\215\025\). )Tj ET q /GS0 gs 351.4960552 0 0 187.6245103 42.5196838 111.859468 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.013 Tw 9 0 0 9 42.5197 100.9701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \205\200\027\026\020\023\022\007\025\031\027 \022)Tj /Span<>> BDC ( )Tj EMC (\022\025\023\032\020\031\033\027\032\020\006\022\031\025\025\031\027 \031\ \033\022\024\020\025\022\027 \026\027\023\031\030\022\n\022 \020\n\023\022\ \021\025\031\b\031 \030\032\027\025\022\032\031\021\020\025\022\t \033\032\ \027\024\020\n\032\020\f\017\025\031\b\031 \033\032\031\024\023\032\020\025\ )Tj 0 Tw (-)Tj 0 -1.2 TD (\024\023\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Schematic and intraoperativ)13.2(e descr)-36.9(ip)13(tion of)]TJ /Span<>> BDC ( )Tj EMC [(the techniq)14.2(ue of)]TJ /Span<>> BDC ( )Tj EMC [(activ)13(e drainag)12(e of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(resacral space)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\ \025\023\031\021 \032\027\023\032\031\024\033\027\n\023\022\021\025\031\b\ \031 \022\024\024\f\027\030\031\021\020\025\022\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (135\) \033\031)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\032\020\024\023\r)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)4(n a)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-8.6(t)-9.6(r)-2(o)-1(s)4.3(p)-11.2(e)-10.9(c)-32.4(t)-29.1(i)-2.9(v)2.3(e s)-14.8(t)-1.1(u)-5.9(d)-7.1(y \()29.6(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1)26.3(3)26(5)58.6(\) b)-2.3(y a)-5.2(g)-6.8(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 703.7118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 703.7118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 703.7118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 692.2505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 692.2505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 692.2505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 680.7892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 680.7892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 680.7892 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 669.3279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 669.3279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 382.9272 669.3279 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 75.647 706.5464 Tm (\026\002\213\006\004\217\003 \(\f\r\003\))Tj 12.944 0 Td (1-\235 \n\006\210\212\212\004 \()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (93\))Tj 14.173 0 Td (2-\235 \n\006\210\212\212\004 \()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (42\))Tj 17.155 0 Td (\026\217\r\n\002 )Tj /T1_1 1 Tf -48.027 -1.433 Td (\204\024\035\024\007\024\005 \(18\22644\))Tj 19.684 0 Td (28,8%)Tj 14.173 0 Td (11,2%)Tj 14.516 0 Td (40%)Tj -48.372 -1.433 Td (\222\030\036\007\027\017\005 \(45\22659\))Tj 19.684 0 Td (38,5%)Tj 14.173 0 Td (17,7%)Tj 14.173 0 Td (56,2%)Tj -48.03 -1.433 Td (\215\024\032\017\035\024\005 \(60\22674\))Tj 19.934 0 Td (1,5%)Tj 14.173 0 Td (2,3%)Tj 14.173 0 Td (3,8%)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 652.6087 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\ \025\023\031\021 \033\032\031\024\033\027\n\023\022\021\025\031\b\031 \022\ \024\024\f\027\030\031\021\020\025\022\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (39\) \033\031)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\032\020\024\023\r)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(p)-2.8(r)-2(o)-1.1(s)4.4(p)-11.3(e)-10.9(c)-32.3(t)-29.1(i)-2.9(v)2.3(e s)-14.8(t)-1.1(u)-5.9(d)-7.2(y \()29.7(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3)24.3(9)61.3(\) b)-2.4(y a)-5.1(g)-6.8(e)]TJ ET /GS2 gs q 1 0 0 1 42.5197 637.3067 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 626.0875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 156.1555 637.3067 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 626.0875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 637.3067 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 626.0875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 637.3067 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 626.0875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 626.0875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 625.8375 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 625.8375 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 625.8375 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 625.8375 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 614.6262 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 614.3762 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 603.1649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 614.3762 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 603.1649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 614.3762 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 603.1649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 614.3762 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 603.1649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 603.1649 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 602.9149 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 591.7036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 602.9149 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 591.7036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 602.9149 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 591.7036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 602.9149 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9272 591.7036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 591.7036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 591.4536 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 591.4536 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 591.4536 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 382.9272 591.4536 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 75.647 628.6721 Tm (\026\002\213\006\004\217\003 \(\f\r\003\))Tj 13.194 0 Td (\017\217\b\002\b\004\235 \()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15\))Tj 13.907 0 Td (\255\006\004\b\r\b\t\235 \()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (24\))Tj 17.171 0 Td (\026\217\r\n\002 )Tj /T1_1 1 Tf -48.027 -1.433 Td (\204\024\035\024\007\024\005 \(18\22644\))Tj 20.026 0 Td (23%)Tj 13.831 0 Td (30,7%)Tj 14.173 0 Td (53,7%)Tj -48.03 -1.433 Td (\222\030\036\007\027\017\005 \(45\22659\))Tj 19.684 0 Td (10,2%)Tj 14.173 0 Td (25,6%)Tj 14.173 0 Td (35,8%)Tj -48.03 -1.433 Td (\215\024\032\017\035\024\005 \(60\22674\))Tj 19.934 0 Td (5,2%)Tj 14.173 0 Td (5,2%)Tj 13.923 0 Td (10,4%)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 42.5197 574.7344 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \217\240\212\020\t \200\020\032\020\n\023\027\032\022\024\023\022\n\020\ \032\020\025\027\025\022\235 \033\032\t\026\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.318 0 Td [( G)-5.7(e)-7(n)-2.4(e)-6(r)3.4(a)-4.5(l c)-2.5(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.5(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-1.9(e)-10.9(c)-32.4(t)-2(a)-4.5(l i)4(n)3.7(j)2.4(u)1.6(r)-39(i)-1.4(e)-22(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 559.4324 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 547.9631 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4783 559.4324 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 548.2131 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 559.4324 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 559.4324 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 548.2131 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 559.4324 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 496.313 548.2131 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 536.744 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.2283 547.9631 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 536.744 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 547.9631 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 536.744 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 547.9631 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 536.744 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 547.9631 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 536.744 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 536.744 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 536.494 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 525.2827 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 536.494 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 525.2827 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 536.494 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 525.2827 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 536.494 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 525.2827 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 536.494 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 525.2827 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 525.2827 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 525.0327 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 513.8214 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 525.0327 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 513.8214 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 525.0327 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 513.8214 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 525.0327 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 513.8214 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 525.0327 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 513.8214 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 513.8214 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 513.5714 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 502.3601 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 513.5714 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 502.3601 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 513.5714 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 502.3601 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 513.5714 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 502.3601 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 513.5714 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 502.3601 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 502.3601 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 502.1101 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 490.8988 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 133.4783 502.1101 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 490.8988 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 502.1101 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 490.8988 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 502.1101 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 490.8988 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 502.1101 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 490.8988 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 490.8988 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 490.6488 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 490.6488 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 490.6488 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 490.6488 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6043 490.6488 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 62.0003 545.0632 Tm (\022\004\b\235\227\t\005 \004\n\r\b\003)Tj 16.067 0.717 Td (1-\235 \n\006\210\212\212\004 \()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (93\))Tj 22.677 0 Td (2-\235 \n\006\210\212\212\004 \()Tj /T1_4 1 Tf (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (42\))Tj -27.663 -1.434 Td (\034\213\002\f\t\006\002\004\b\b\013\r)Tj 12.271 0 Td (\255\002\201\r\003\004\b\b\013\r)Tj 10.407 0 Td (\034\213\002\f\t\006\002\004\b\b\013\r)Tj 12.271 0 Td (\255\002\201\r\003\004\b\b\013\r)Tj /T1_1 1 Tf -48.079 -1.433 Td (\215\031\035\036\r\t\036)Tj 15.682 0 Td (3,2%)Tj 11.089 0 Td (12,9%)Tj 11.931 0 Td (0%)Tj 10.996 0 Td (4,7%)Tj -49.697 -1.433 Td (\210\f\022\024\035\024\004\027\t\036)Tj 15.682 0 Td (7,5%)Tj 11.089 0 Td (72,1%)Tj 11.931 0 Td 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Ov}b8-tGgւ(10iSkGsh,]>? ?Z( ? z"@[ ~m_?CGgEݿAh<;cC+` o59~=im}FkYxg3h!䯱` n͔YH W؃k oG 6WE`@JΙT>?GU-OY|59~QDF?GTF?GU-J-t~6ͣu'q\?740yGI(? ?Ot~6֊(]Ǫ4vψC`z;g){ͣtkGsh,]hL ?˸v0~Se$t~6ͣu^8{P@_]}qȉ+{ͣtkGsh,]h?jp0O\` )8[ ~m_?CGgE`j?o,ʟ j"b!gGTvψSOY|59~QC6?3GTtψSOY|59~Qy#6kZ2& gJ/{8IIAy Ro^ȋ;qDEhiV8Y0c*B,BQ'`K,gQ&+J*j,ay7}++Ξ V#aqqk~z",\d'R endstream endobj 1368 0 obj <>stream endstream endobj 1364 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.177 Tw 10 0 0 10 70.8661 724.8299 Tm [(\022\024\027\235\035\017\022\021\024\r. \203\026\017\002\024\035\036\036\ )0.5(\004\026\f\021\t\n \n\036\b\026\027\017\n\024\n \r\024\027\017\022)]TJ 0 Tw (-)Tj -0.007 Tw 0 -1.218 TD (\027\024\r\036\027\017\016 \220\021\017\b \030\026\027\036\027\017\005 \016\ \r\035\016\033\021\f\016 \024\020\027\036\f\021\030\036\035\034\027\t\036\ \024\f\022\024)Tj 0 Tw (-)Tj 0.039 Tw T* (\035\024\004\027\t\036 \023\024\r\030\036\032\007\036\027\017\016 \(71\226\ 85%\). \200\030\t\r\027\024\005 \n\036\b\026\027\017\n )Tj 0.133 Tw T* (\023\024\r\030\036\032\007\036\027\017\005 \023\030\016\n\024\005 \022\017\ \001\022\017 \f\024\f\021\026\r\035\016\036\021 \024\022\024\035\024 23%\ . )Tj 0.14 Tw T* (\212\024\035\016 \r\027\036\002\030\033\001\017\027\027\t\b \023\024\r\030\ \036\032\007\036\027\017\005 \n\024\032\036\021 \007\024\f\021\017\020\026\ \021\034 )Tj 0.178 Tw T* (70% [6]. \200)Tj /Span<>> BDC ( )Tj EMC (32,3% \217\215\025 \r\027\036\002\030\033\001\017\027\027\024\005 \035\024\ \022\026\035\017\026\006\017\017 )Tj 0.492 Tw 0 -1.218 TD [(\r\t\016\r\035\016\033\021\f\016 )0.5(\021\024\035\034\022\024 \r)]TJ /Span<>> BDC ( )Tj EMC [(\006\036\027\021\030\026\035\034\027\t\b )0.5(\r\024\036\027\027\024-\n\036\007\017)]TJ 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD (\006\017\027\f\022\017\b \024\030\020\026\027\017\026\006\017\016\b, \004\ \021\024 \027\036\n\017\027\031\036\n\024 \f\022\026\t\r\026\036\021\f\016\ )Tj 0.001 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\b \007\026\035\034\027\036\005\001\ \036\020\024 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016)Tj 0 Tw (-)Tj 0.159 Tw T* (\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\r\017\r\026\033\013\017\n\017\f\016 )0.5(\024\f\035\024\032\027\036\027\017\016\n\017 )0.5([7]. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.177 Tw T* [(\004\026\f\021\024\021\026 )0.5(\030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\005 )0.5(\007\024\f\021\017\020\026\036\021 )0.5(65%, \026)]TJ /Span<>> BDC ( )Tj EMC 20.816 0 Td (\035\036)Tj 0 Tw (-)Tj -20.816 -1.218 Td (\021\026\035\034\027\024\f\021\034 \n\024\032\036\021 \023\030\036\r\t\001\ \026\021\034 45% [8\22611].)Tj 0.218 Tw 0 -1.218 TD (\221\026\022\017\n \024\002\030\026\024\n, \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \017\n\036\027\036\027\017\016 \b\026\030\026\022\ \021\036\030\017\f\021\017\022 )Tj 0.031 Tw 0 -1.218 TD (\f\024\r\030\036\n\036\027\027\t\b \030\026\027\016\013\017\b \f\027\026\ \030\016\007\024\r, \024\f\024\002\036\027\027\024\f\021\036\005 \220\021\ \017\024)Tj 0 Tw (-)Tj 0.238 Tw 0 -1.218 TD (\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\026 \002\024\036\r\024\005 \b\017\030\031\ \030\020\017\004\036\f\022\024\005 \021\030\026\r\n\t, )Tj 0.079 Tw T* (\021\030\036\002\031\036\021\f\016 \f\024\002\035\033\007\036\027\017\036\ \036\007\017\027\024\020\024 \023\024\007\b\024\007\026 \022)Tj /Span<>> BDC ( )Tj EMC (\026\035\020\024\030\017\021\n\031 )Tj 0.103 Tw T* (\024\022\026\026\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\024\ \005 \023\024\n\024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\026\b )Tj -0.034 Tw T* (\n\036\007\017\006\017\027\f\022\024\005 \220\r\026\022\031\026\006\017\017\ \(\233\204\233\) \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\030\024\235\017\035\026\022\021\017\022\017 )Tj 0.345 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\031\023\017\030\024\r\026\027\017\016 \020\027\024\005\027\024-\027\ \036\022\030\024\021\017\004\036\f\022\017\b \024\f\035\024\032\027\036\027\ \017\005 )Tj 0 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r \021\026\026 \(\025\215\221\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 456.9138 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.131 Tw 10 0 0 10 70.8661 432.5578 Tm [(\037\036\035\034\033 )0.5(\027\026\f\021\024\016\013\036\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\002\t\035\024 )0.5(\017\031\004\017\021\034 )0.5(\024\f\024)]TJ 0 Tw (-)Tj 0.199 Tw T* (\002\036\027\027\024\f\021\017 \217\215\025 \024\002\036\017\b \035\024\022\ \026\035\017\026\006\017\005, \024\002\255\201\n \024\023\036\030\026\006\ \017\005 )Tj 0.104 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\n\036\r\001\017\036 \n\036\f\021\024 \024\f\035\ \024\032\027\036\027\017\016. \203\026)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.024 Tw T* [(\027\024\r\026\027\017\017 \023\024\035\031\004\036\027\027\t\b )0.5(\030\036\031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\r\026\027\ \017\016, )0.5(\030\026)]TJ 0 Tw (-)Tj 0.21 Tw T* (\030\026\002\024\021\026\027 \026\035\020\024\030\017\021\n \024\022\026\ \026\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\ \n\024\013\017 )Tj 0.287 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\217\215\025 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \007\017\235\235\036\030\036\027\006\017\030\024\r\ \026\027\027\024\020\024 \023\024\007\b\024\007\026 )Tj -0.032 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\033 \024\002\255\201\n\026 \024\ \023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\007\030\036)Tj 0 Tw (-)Tj T* (\027\017\030\024\r\026\027\017\033 \025\215\221.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 310.7778 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.025 Tc 0.074 Tw 10 0 0 10 70.8661 286.4218 Tm (\200 \023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\021\026 2022 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\036\022\026\002\030\034 2024 \020. \023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.031 Tw T* (\017\r\036\007\201\027 \026\027\026\035\017 \030\036\031\035\034\021\026\ \021\024\r \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\ \004\036)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.023 Tw T* (\027\017\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\021\r\036\030\032\007\201\027\027\t\n \007\017\026\020\027\024\ \024\n \217\215\025.)25( )]TJ -0.029 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\004\036\027\t \ \023\026\006\017\036\027\021\t, \023\030\024\b\024\007\017\r\001\017\036\ )25( )]TJ -0.001 Tw T* (\220\021\026\023\027\024\036 \b\017\030\031\030\020\017\004\036\f\022\024\ \036 \035\036\004\036\027\017\036 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (135\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc -0.061 Tw T* (\021\030\024\f\023\036\022\021\017\r\027\024\n \017\f\f\035\036\007\024\r\ \026\027\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (1-\033 \020\030\031\023\023\031 \()Tj /T1_2 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.025 Tc -0.061 Tw /Span<>> BDC 19.771 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(93\))25( )]TJ 0.336 Tw -19.771 -1.218 Td (\r\022\035\033\004\036\027\t \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC [(\r\027\031\021\030\017\002\030\033\001\017\027\027\t\n\017 \217\215\025,\ )25( )]TJ 0.126 Tw T* [(\r\024 )0.5(2-\033 )0.5(\020\030\031\023\023\031 )0.5(\()]TJ /T1_2 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.025 Tc 0.126 Tw /Span<>> BDC 7.61 0 Td ( )Tj EMC 0.383 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td (42\))Tj /Span<>> BDC ( )Tj EMC 1.828 0 Td [(\227 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.254 0 Td [(\r\027\036\002\030\033\001\017\027\027\t\n\017 )0.5(\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.025 Tc 0.068 Tw -12.985 -1.218 Td (\027\036\027\017\016\n\017. \215\030\024\f\023\036\022\021\017\r\027\026\ \016 \020\030\031\023\023\026 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(39\) \027\026\002\030\026\027\026)25( )]TJ 0.034 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \031\f\021\026\027\024\r\035\036\027\024 \r\027\ \036\002\030\033\001\017\027)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.191 Tw T* (\027\024\036 \023\024\r\030\036\032\007\036\027\017\036 \023\030\016\n\024\ \005 \022\017\001\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\022\024\020\024\030\021\027\024\n)25( )]TJ 0.036 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017, \r)Tj /Span<>> BDC ( )Tj EMC [(\024\f\027\024\r\027\031\033 \020\030\031\023\023\031 \023\030\024\f\023\ \036\022\021\017\r\027\024\020\024)25( )]TJ 0.112 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \()Tj /T1_2 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.025 Tc 0.112 Tw /Span<>> BDC 7.357 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15\) \r\022\035\033\004\036\027\t \023\026\006\017\036\027\021\t, \r)Tj /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.343 Tw -7.357 -1.218 Td (\004\036\027\017\017 \022\024\021\024\030\t\b \023\030\017\n\036\027\016\ \035\026\f\034 \n\036\021\024\007\017\022\026 \026\022\021\017\r\027\024\ )Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.365 Tw T* [(\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\036\f\026\ \022\030\026\035\034\027\024\020\024 \023\030\024\f\021\030\026\027\f\021\ \r\026.)25( )]TJ -0.017 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031 \f\030\026\r\027\036\027\017\016 \()Tj /T1_2 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.025 Tc -0.017 Tw /Span<>> BDC 9.708 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (24\) \r\024\001\035\017 \023\026\006\017\036\027\021\t, \022)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.009 Tw -9.708 -1.218 Td (\021\024\030\t\n \023\030\017\n\036\027\016\035\026\f\034 \f\021\026\027\ \007\026\030\021\027\026\016 \n\036\021\024\007\017\022\026 \002\017\035\ \026\021\036)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.034 Tw T* [(\030\026\035\034\027\024\020\024 \023\026\030\026\030\036\022\021\026\035\ \034\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016. \222\ \035\036\007\031\036\021)25( )]TJ -0.024 Tw 23.244 64.543 Td (\024\021\n\036\021\017\021\034, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r \024\f\027\024\r\027\024\005 \020\030\ \031\023\023\t \217\215\025 \027\036)25( )]TJ 0.214 Tw 0 -1.218 TD (\002\t\035\024 \007\017\026\020\027\024\f\021\017\030\024\r\026\027\024 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\t\b \220\021\026\023\026\b \n\036)Tj 0 Tc 0 Tw (-)Tj 0.025 Tc 0.266 Tw 0 -1.218 TD [(\007\017\006\017\027\f\022\024\005 \220\r\026\022\031\026\006\017\017. \025\ \030\017\021\036\030\017\016\n\017 \027\036\r\022\035\033\004\036\027\017\ \016)25( )]TJ -0.025 Tw 0 -1.218 TD (\016\r\035\016\035\017\f\034:)Tj 0 Tc 0 Tw 0 -1.218 TD (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\210\021\022\026 \024\021 \017\f\f\035\036\007\024\r\026\027\017\016.)Tj -1.296 -1.218 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\203\017\022\017\036 \217\215\025.)Tj 1.397 Tw -1.296 -1.218 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\210\002\001\017\030\027\t\036 \007\036\235\036\022\021\t \022\030\036\f\ \021\006\024\r\024\005 \024\002\035\026\f\021\017 )Tj 0 Tw -1.296 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017.)Tj -0.038 Tw 0 -1.218 TD [(\215\030\017 \030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \017\ \f\f\035\036\007\024\r\026\027\017\017 )0.5(\017\031\004\036\027\t )0.5(\024\f\024\002\036\027)]TJ 0 Tw (-)Tj 0.101 Tw T* (\027\024\f\021\017 \b\026\030\026\022\021\036\030\017\f\021\017\022 \030\ \026\027\016\013\017\b \026\020\036\027\021\024\r, \f\024\004\036\021\026\ \027\027\024\f\021\034 )Tj 0.005 Tw T* [(\023\024\r\030\036\032\007\036\027\017\005 )0.5(\f\n\036\032\027\t\b )0.5(\024\030\020\026\027\024\r \032\017\r\024\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\026. )0.5(\221\026\022\032\036 )]TJ 0.017 Tw T* (\023\030\024\017\r\036\007\036\027\026 \024\006\036\027\022\026 \024\002\ \255\201\n\026 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036\027\017\016 )Tj 0.155 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \233\204\233, \017\n\036\r\001\ \017\036 \n\036\f\021\024 \024\f\035\024\032\027\036\027\017\016. )Tj 0.39 Tw T* [(\216\017\030\031\030\020\017\004\036\f\022\024\036 )0.6(\035\036\004\036\027\017\036 )0.5(\r\t\023\024\035\027\016\035\024\f\034 )0.6(\f\021\026\027\007\026\030\021\027\t\n )]TJ 0.359 Tw T* [(\f\023\024\f\024\002\024\n, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.757 0 Td [(\023\030\017\n\036\027\036\027\017\036\n )0.6(\017\r\036\f\021\027\t\b )0.5(\n\036\021\024\007\024\r )0.6(\b\017)]TJ 0 Tw (-)Tj 0.247 Tw -5.757 -1.218 Td (\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ . \204\036\021\024\007\017\022\026 \026\022\021\017\r\027\024\020\024 \007\ \030\036\027\017)Tj 0 Tw (-)Tj 0.403 Tw T* (\030\024\r\026\027\017\016 \023\030\036\f\026\022\030\026\035\034\027\024\ \020\024 \023\030\024\f\021\030\026\027\f\021\r\026 \024\021\035\017\004\ \026\035\026\f\034 )Tj 0.282 Tw T* [(\023\030\017\n\036\027\036\027\017\036\n \f\017\f\021\036\n\t )0.5(\007\r\031\b\023\030\024\f\r\036\021\027\t\b \021\030\031\002\024\022, \023\ \024)]TJ 0 Tw (-)Tj 0.285 Tw T* (\r\024\035\016\033\013\017\b \024\f\031\013\036\f\021\r\035\016\021\034\ \f\026\027\026\006\017\033 \024\027\t \024\023\036\030\026\006\017\017\ , )Tj 0.087 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\024\027\021\030\024\035\017\030\024\r\026\021\034\ \023\030\024\b\024\007\017\n\024\f\021\034 \f\026\n\017\b \007\030\036\027\ \026)Tj 0 Tw (-)Tj T* (\032\036\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.346 Tw T* (\215\030\017 \023\030\024\f\023\036\022\021\017\r\027\024\n \022\024\020\ \024\030\021\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \017\031\ )Tj 0 Tw (-)Tj 0.117 Tw T* (\004\036\027\t \035\026\002\024\030\026\021\024\030\027\t\036 \007\026\027\ \027\t\036, \024\021\024\002\030\026\032\026\033\013\017\036 \f\021\036\023\ \036\027\034 )Tj 0.059 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\024\005 \030\036\026\022\006\ \017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \r\026\030\017\026\027\021\026\ )Tj 0.339 Tw T* [(\007\030\036\027\017\030\024\r\026\027\017\016 \025\215\221. )0.5(\210\002\255\036\022\021\017\r\027\026\016 \024\006\036\027\022\026 \022\ \035\017\027\017\004\036)]TJ 0 Tw (-)Tj 0.132 Tw T* (\f\022\024\020\024 \220\235\235\036\022\021\026 \023\030\024\017\r\024\007\ \017\035\026\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\200\202\231 \002\024\035\017. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016)Tj 0 Tw (-)Tj 0.075 Tw T* (\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\024\021\022\017\n\017 \f\030\024\022\026\n\017 \023\030\036\ \002\t\r\026\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233, \024\006\036\027\022\026 )Tj 0.146 Tw T* (\030\036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016 \023\ \030\024\r\024\007\017\035\026\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (1-\036 \017)Tj /Span<>> BDC ( )Tj EMC (3-\f\031\021\022\017. )Tj -0.043 Tw T* (\203\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \023\024\035\031\004\036\027\027\t\b \030\ \036\031\035\034\021\026\021\024\r \017\f\f\035\036\007\024\r\026\027\017\ \016, )Tj 0.279 Tw T* (\030\026\030\026\002\024\021\026\027 \007\017\235\235\036\030\036\027\006\ \017\030\024\r\026\027\027\t\005 \026\035\020\024\030\017\021\n \024\022\ \026\026)Tj 0 Tw (-)Tj T* (\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\ \024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\217\215\025.)Tj /T1_3 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_0 1 Tf 0.143 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\017\005 )0.6(\026\027\026\035\017 )0.6(\r\t\023\024\035\027\016\035\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.836 0 Td [(\023\024\n\024\013\017 )0.5(\f\021\026)]TJ 0 Tw (-)Tj 0.495 Tw -16.836 -1.218 Td [(\021\017\f\021\017\004\036\f\022\024\020\024 \023\026\022\036\021\026 S)15(t)15(a)15(t)-32(ist)-31.9(ica 12 \(TIBC)13(O, \222\231\202\). )]TJ 0.033 Tw T* [(\215\030\024\r\036\030\022\031 )0.5(\027\024\030\n\026\035\034\027\024\f\021\017 )0.6(\030\026\f\023\030\036\007\036\035\036\027\017\016 )0.6(\007\026\027\027\t\b )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.878 0 Td (\024\021)Tj 0 Tw (-)Tj -0.018 Tw -20.878 -1.218 Td (\007\036\035\034\027\t\b \020\030\031\023\023\026\b \f\030\026\r\027\036\ \027\017\016 \023\030\024\r\024\007\017\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.181 Tw T* [(\027\017\036\n \022\030\017\021\036\030\017\016 \231\026\023\017\030\024\ \226\211\017\035\022\026. )0.5(\222\030\026\r\027\036\027\017\036 \017\f\f\035\036\007\031)]TJ 0 Tw (-)Tj 0.16 Tw T* (\036\n\t\b \020\030\031\023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\n \023\030\017\027\026\022\026\n\ \023\030\024\r\024\007\017\035\017 )Tj 0.31 Tw T* (\n\036\021\024\007\024\n \026\027\026\035\017\026 \021\026\002\035\017\006\ \f\024\023\030\016\032\036\027\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036)Tj 0 Tw (-)Tj 0.099 Tw T* (\027\036\027\017\036\n \022\030\017\021\036\030\017\016 \245)Tj 0 Tw 5.83 0 0 5.83 384.0832 241.0398 Tm (2)Tj 0.099 Tw 10 0 0 10 386.9982 237.7098 Tm ( \215\017\030\f\024\027\026. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b, \022\024\020\007\026 \024\032\017)Tj 0 Tw (-)Tj 0.143 Tw -8.369 -1.218 Td (\007\026\036\n\024\036 \022\024\035\017\004\036\f\021\r\024 \027\026\002\ \035\033\007\036\027\017\005 \002\t\035\024 \n\036\027\036\036 10, \017\f\ )Tj 0 Tw (-)Tj 0.051 Tw T* (\023\024\035\034\024\r\026\035\017 \007\r\031\f\021\024\030\024\027\027\ \017\005 \021\024\004\027\t\005 \022\030\017\021\036\030\017\005 \205\017\ \001\036\030\026. )Tj 0.009 Tw T* [(\217\026\035\017\004\017\016 \f\030\026\r\027\017\r\026\036\n\t\b )0.5(\023\024\022\026\026\021\036\035\036\005 \f\004\017\021\026\035\017 \f\021\ \026\021\017\f)]TJ 0 Tw (-)Tj T* (\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 152.4638 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.156 Tw 10 0 0 10 303.3071 128.1078 Tm (\215\030\017 \n\036\032\020\030\031\023\023\024\r\024\n \f\030\026\r\027\ \036\027\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\027\024\n\031 \023\030\017)Tj 0 Tw (-)Tj -0.029 Tw T* (\027\026\022\031, \031\f\021\026\027\024\r\035\036\027\024, \004\021\024\ \017\f\f\035\036\007\031\036\n\t\036 \020\030\031\023\023\t, \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, )Tj 0.455 Tw T* (\002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\017\r\026\036\n\t\n \023\026\030\026\n\036\021\030\026\n\ . )Tj 0.307 Tw T* (\222\030\036\007\027\017\005 \r\024\030\026\f\021 \f\024\f\021\026\r\017\ \035 34,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (4,2 \020\024\007\026 \(\024\021 21 )Tj 0.029 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (65 \035\036\021\), \007\026\027\027\t\036 \023\030\036\007\f\021\026\r\035\ \036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\026\b 1,2. \215\024\035 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.0776 56.0378 Tm (58)Tj ET endstream endobj 1363 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 \220\n\005\002\005\013\n\225\ \004\016\r)10(\025\221 \224\025\024\025\234\n )]TJ 0 -1 TD [(\224\005\n\022\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\ \r\n \t\017\022\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 39.559 1 Td [(A dif)-30.9(fer)31(entiated algorithm for pr)20(oviding sur)31(gical car)31(e )]TJ 0.177 -1 Td [(for\022r)31.1(ectal injuries at th)10.9(e\022stages of\022medical e)11(v)10(acuation)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 743.0544 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 743.0544 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 705.8466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 705.8466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 348.3618 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 348.3618 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 311.154 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 311.154 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 247.4848 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.035 Tc 0.345 Tw 8 0 0 8 42.5596 731.2159 Tm [(\020\036\017)5( )0.5(\016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_2 1 Tf 0.025 Tc 0.35 Tw 9.545 0 Td [( )0.5(\025\017\n)]TJ /Span<>> BDC ( )Tj EMC 2.938 0 Td [(\230.\224., )0.6(\204\031\f\026\017\035\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.722 0 Td [(\200.\202., )0.5(\202\002\007\031\030\026\b\n\026\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 9.445 0 Td [(\217.\205. )0.5(\212\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\005 )0.5(\026\035\020\024\030\017\021\n )0.6(\024\022\026\026\027\017\016 )0.5(\b\017\030\031\030\020\017\004\036)]TJ 0 Tc 0 Tw (-)Tj 0.023 Tc 0.177 Tw -29.655 -1.2 Td (\f\022\024\005 \023\024\n\024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\016\b \023\030\016\n\024\005 \022\017\001\022\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\026\b \n\036\007\017\006\017\027\f\022\024\005 \220\r\026\ \022\031\026\006\017\017. )Tj /T1_3 1 Tf -0.023 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_2 1 Tf 0.177 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(56\22664.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2026-25-1-56-64)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 79.8111 679.6774 Tm [(A dif)-31(fer)31.1(entiated algorithm for pr)20(oviding sur)31.1(gical car)31(e )]TJ 0.065 -1.167 Td [(for r)31(ectal injuries at th)11(e\022)-23.3(stages of\022)-23.3(medical e)11(v)10(acuation)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 634.1734 Tm [(Igor\022)-23.3(Y)40(u.\022)-23.2(Kim)]TJ 8.162 0 0 8.162 111.295 638.8354 Tm (2)Tj 0.023 Tw 14 0 0 14 115.931 634.1734 Tm [(, Vitaly\022)-23.2(A)-31(.\022)-23.3(Musailov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 227.5629 638.8354 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 238.8835 634.1734 Tm [(, Rinat\022)-23.2(F)94(.\022)-23.3(Abdur)21(akhmanov)]TJ 0 Tw 8.162 0 0 8.162 384.1158 638.8354 Tm (3)Tj 5.83 0 0 5.83 42.5197 619.8342 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 616.5042 Tm [(A)-31(.A)-31(.\022)-23.2(Vishne)11(v)10(sky National Medical Resear)31(ch Center for Militar)-30.9(y)-21(-Medical Oper)21(ations of\022)-23.3(th)11(e Russian Ministr)-31(y )]TJ -0.331 -1.2 Td [(of\022)-23.3(Defense \(p. Nov)-21(y)31(, d. 1)68.9(, Kr)21(asnogor)20(sk, Moscow Region, 1)150(43)58(420, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 595.8342 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 592.5042 Tm [(Br)21(anch No. 1 of\022)-23.3(th)11(e A)-30.9(.A)-31(.\022)-23.3(Vishne)11(v)10(sky National Medical Resear)31.1(ch Center for Militar)-30.9(y)-21(-Medical T)40(echnologies of\022)-23.2(th)11(e )]TJ -0.331 -1.2 Td [(Ministr)-30.9(y of\022)-23.3(Defense of\022)-23.3(th)11(e Russian F)20(eder)21(ation \(Sv)12(etlay)21(a st., 1)212(1)69(, Kr)21(asnogor)20.1(sk, Moscow Region, 1)150(43)58(409, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 571.8342 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 568.5042 Tm [(Br)21(anch of\022)-23.3(th)11(e Militar)-30.9(y Medical Academ)21(y in th)11(e\022)-23.2(cit)-20(y of\022)-23.3(Moscow \(Malay)21(a Ch)11(erkiz)10(ov)10(skay)21(a st., 7)127(, Moscow)22(, )]TJ -0.331 -1.2 Td [(1)75(0)37(7)57(3)11(9)35(2, Russia\))]TJ /T1_3 1 Tf -0.007 Tw 9 0 0 9 90.7087 538.0003 Tm [(AIM: to dev)13(elop an algor)-36.9(ithm for rectal injur)-36.9(ies \(RI\) at the stag)12(es of medical ev)16(acuation \(MEE\), based on dif)-40(ferenti)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD [(ated app)46.1(roach to surg)12.1(er)-43(y and indications for drainag)12(e of the pelvic spaces \(PCS\).)]TJ 0.107 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: in March 2023)]TJ /Span<>> BDC ( )Tj EMC [(\227 December 2024, 135 patients \(ag)12(ed 34.3)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(4.2; 99.2% males\) w)12(ere )]TJ 0.07 Tw T* [(included in retrospectiv)13(e study)32(. The 1st g)14(roup \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(93\) included patients with intra-abdominal RI. The 2nd g)14(roup )]TJ 0.015 Tw T* (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.922 0 Td [(42\) included )0.5(patients )0.5(with )0.5(e)-15(xtraper)-37(itoneal )0.5(RPK. )0.5(The character)-36.9(istics )0.5(of the w)12(ounds, )0.5(the combination of injur)-37(ies )]TJ -0.014 Tw -1.922 -1.111 Td [(with o)13(ther org)12(ans and systems, type and v)13(olume of surg)12(er)-43(y w)12(ere ev)16(aluated. In g)14(roup with e)-15(xtraper)-37(itoneal injur)-37(ies 18 )]TJ 0.02 Tw T* [(patients under)-31.9(w)12(ent surg)12(er)-43(y with activ)13(e drainag)12(e of the p)46(resacral space )0.5(and 24)]TJ /Span<>> BDC ( )Tj EMC [(\227 stand)26(ard bilateral per)-37(ineal pelvic )]TJ 0.023 Tw T* [(drainag)12.1(e. P)18(ain, clinical and biochemical indicators w)12(ere ev)16(aluated on the 1st and 3rd d)26(ays.)]TJ 0.131 Tw T* [(RESUL)30(T)-10(S: )0.6(RI )0.5(sutur)-36.9(ing )0.5(w)13(as )0.6(per)-34(for)-14(med )0.6(in )0.5(28.5\23130.2% )0.6(of )0.5(case, )0.6(rectal )0.6(resection)]TJ /Span<>> BDC ( )Tj EMC 31.323 0 Td [(\227 )0.5(in )0.6(57.9%, )0.5(more )0.6(of)-46(ten )0.5(in )0.6(intra-)]TJ -0.004 Tw -31.323 -1.111 Td [(abdominal injur)-36.9(ies)]TJ /Span<>> BDC ( )Tj EMC [(\227 \(69.8% vs 11.9% for e)-15(xtraabdominal; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.05\). Har)-40(tmann)24(\222)37(s p)46(rocedure w)13(as done in 21.5% of )]TJ -0.028 Tw T* [(cases, and a loop colostom)11.1(y)]TJ /Span<>> BDC ( )Tj EMC [(\227 in 29% of cases. In 35.7% of clinical cases, a rectal resection w)13(as done due to injur)-37(ies )]TJ -0.012 Tw T* [(missed at p)46(revious stag)12(es. N)18(ecro)13(tic chang)12(es in the pelvis dev)13(eloped on the 2nd d)26(ay in 12.5% of cases, and on the 3rd )]TJ 0.019 Tw T* [(d)26(ay or more in 62.5% of cases with stand)26.1(ard bilateral pararectal drainag)12(e. In the g)14(roup with activ)13(e drainag)12(e of the )]TJ 0.023 Tw T* [(p)46(resacral space no ma)10.1(jor com)16(plications occur)-15.9(red.)]TJ 0.056 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: the dev)13(eloped algor)-36.9(ithm for rectal injur)-37(ies is ef)-40(fectiv)13.1(e, activ)13(e pelvic drainag)12(e is super)-37(ior to stand)26(ard )]TJ 0 Tw 0 -1.111 TD (one.)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 372.731 Tm [(KEYW)22(ORDS:)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( rectum, injur)-43(y)42(, surgical treatment, drainag)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC [(the pelvic spaces, medical treatment stag)12(e)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.035 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.5(O)-4.4(R)9( C)-17.2(I)-15.3(T)45.6(A)37.8(T)-24.2(I)-1(ON:)]TJ /T1_2 1 Tf 0.021 Tc -0.035 Tw 6.372 0 Td [( K)-17.9(i)-3(m I)-10(.)51.8(Y)12.9(u)-8.8(.)-23.2(, M)-5.5(u)-21.6(s)-24.5(a)-14.6(i)-6.9(l)-20.6(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(V)40(.)-23.6(A)-22.8(.)-23.2(, A)-28.2(b)-21.8(d)-8.7(u)-7.3(r)-30.6(a)-10.9(k)-16.6(h)-5.9(m)-8(a)-7.4(n)-11.6(o)-10.1(v)]TJ /Span<>> BDC ( )Tj EMC [(R)-21.2(.)0.7(F)68.5(. A)]TJ /Span<>> BDC ( )Tj EMC [(d)-15.5(i)-11.9(f)-62.2(f)-28.2(e)-11.9(r)-18.8(e)-11.3(n)-17(t)-46(i)-4.8(a)-17.9(t)-24.5(e)-20.7(d a)-11.1(l)-20.3(g)-9.9(o)-11.5(r)-56.2(i)-15.5(t)-25.9(h)-5.9(m f)-25(o)-11.5(r p)-13.4(r)-15.5(o)-10.1(v)-51.5(i)-8.6(d)-15.5(i)-2.9(n)-11.7(g s)-8.6(u)-7.3(r)-16.5(g)-28.6(i)-4.7(c)-21.3(a)-11.1(l c)-21.2(a)-10(r)-18.8(e f)-25(o)-11.5(r r)-18.8(e)-18.8(c)-41.3(t)-36.5(a)-11.1(l i)-2.9(n)-14.2(j)-3.2(u)-7.3(r)-56.2(i)-10.7(e)-22.6(s)21( )]TJ 0.033 Tc 0.02 Tw -6.377 -1.2 Td [(a)-18.2(t t)-26(h)-15.1(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-29.3(t)-36.8(a)-10.7(g)-14.5(e)-22.7(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-16.5(e)-21(d)-15.8(i)-5(c)-21.5(a)-11.4(l e)-15.8(v)-28.4(a)-11.1(c)-12.1(u)-6.5(a)-18.2(t)-46.2(i)-6.7(o)-9.2(n)-5.6(. )]TJ /T1_3 1 Tf 0.043 Tc -0.043 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.8(a)5.8(.)]TJ /T1_2 1 Tf 0.033 Tc 0.02 Tw 23.748 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)20(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)4.1(5)-8.9(6)-25.9(\226)-27.5(6)-25.2(4)-0.9(. \()-0.9(i)-3.2(n R)-6.4(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)2(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.3(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.8(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)]TJ -0.022 Tc 0.022 Tw -23.748 -1.2 Td [(2)-56.4(5)-78.5(-1)-28.1(-)-62.9(5)-63.9(6)-81.7(-)-83(6)-80.2(4)]TJ /T1_1 1 Tf 0.01 Tc 0.053 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_3 1 Tf 0 Tc 0.058 Tw 10.647 0 Td ( \202\022\026 \002\b\031\032\017 \224\032\017\027\021\022\007, \214\022\f\ \022\020\f \2421\214\216\221\210 \253\001\215\002\037 \211\215 \022\026\ \027\025\022 \003.\003.)Tj /Span<>> BDC ( )Tj EMC (\211\022\213\025\027\021\024\n\031\b\031\273 \215\022\025\031\240\031\032\ \031\025\013 \206\031\024\024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\021\027\023\f\020\t, )Tj 0.023 Tw -10.652 -1.2 Td (\021\f. 11, \202\032\020\024\025\031\b\031\032\024\n, \215\031\024\n\031\ \021\024\n\020\t \031\240\f\020\024\023\017, 143409, \206\031\024\024\022\ \t; \023\027\f.: +7 \(938\) 151-60-60; e-mail: kim79igor@yandex.ru)Tj /T1_1 1 Tf 0.01 Tc -0.021 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_3 1 Tf 0 Tc -0.016 Tw 13.972 0 Td [( Kim )0.5(Igor )0.5(Y)39(ur)-37(ievich, )0.5(Branch )0.5(N)17(o. )0.5(1 of)]TJ /Span<>> BDC ( )Tj EMC 13.897 0 Td [(the )0.5(F)10.9(ederal S)28(tate )0.5(Budg)12.1(etar)-43(y Institution )0.6(\244N)18(ational )0.5(Medical )0.5(R)21(esearch )0.5(Center )]TJ -0.009 Tw -27.874 -1.2 Td [(for Militar)-42.9(y)-14(-Medical T)54(echnologies named af)-46(ter A.A.)]TJ /Span<>> BDC ( )Tj EMC (Vishnevsky\245 of)Tj /Span<>> BDC ( )Tj EMC [(the Ministr)-43(y of)]TJ /Span<>> BDC ( )Tj EMC (Defense of)Tj /Span<>> BDC ( )Tj EMC [(the R)22(ussian F)11(ederation, Sv)13(etlaya st., 11, Krasnogorsk, )]TJ 0.023 Tw 0 -1.2 TD [(Moscow R)21(egion, 143409, R)22(ussia; e-mail: kim79igor@yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 24.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 24.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 188.9979 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.521 Tw 10 0 0 10 42.5197 164.6418 Tm [(\222\024\r\030\036\n\036\027\027\026\016 )0.6(\f\017\f\021\036\n\026 )0.5(\n\036\007\017\006\017\027\f\022\024\020\024 )0.6(\024\002\036\f\023\036\004\036\027\017\016 )]TJ 0.621 Tw 0 -1.218 TD [(\023\024\r\024\035\016\036\021 )0.6(\030\026\f\001\017\030\017\021\034 )0.5(\r\024\n\024\032\027\024\f\021\017 )0.6(\n\036\007\017\006\017\027\f\022\017\b )]TJ 0.091 Tw T* (\023\024\007\030\026\007\036\035\036\027\017\005 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \023\030\017\002\035\017\032\036\027\017\016 \f\023\036\006\ \017\026\035\017\017\030\024)Tj 0 Tw (-)Tj 0.085 Tw T* [(\r\026\027\027\024\005 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.6(\023\024\n\024\013\017, )0.5(\021\036\n )0.5(\f\026\n\t\n )0.6(\023\024\r\t\f\017\021\034 )]TJ 0.641 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \035\036\004\036\002\027\ \024-\220\r\026\022\031\026\006\017\024\027\027\t\b \n\036\030\024\023\030\ \017)Tj 0 Tw (-)Tj 0.361 Tw T* (\016\021\017\005 [1,2]. \200\026\030\017\026\027\021 \035\036\004\036\002\ \027\024-\220\r\026\022\031\026\006\017\024\027\027\024\020\024 \024\002\ \036)Tj 0 Tw (-)Tj 0.116 Tw T* (\f\023\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n \022\024\027\022\030\036\021\027\024\n \f\035\031\ \004\026\036 \r\026\032\027\024 \024\023\030\036)Tj 0 Tw (-)Tj 0.352 Tw T* (\007\036\035\016\021\034 \017\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\005 \n\036\007\017\022\024-\021\026\ \022\021\017\004\036\f\022\024\005 )Tj 0.233 Tw 23.244 10.96 Td (\024\002\f\021\026\027\024\r\022\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\024\n\024\032\027\024\f\021\036\005 )0.5(\024\022\026\026\027\017\016 \f\r\024\036\r\030\036\n\036\027)]TJ 0 Tw (-)Tj 0.458 Tw T* [(\027\024\005 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.6(\023\024\n\024\013\017 )0.5([3]. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 16.482 0 Td (\r\024\024\030\031\032\201\027\027\t\b )Tj 0.632 Tw -16.482 -1.218 Td (\022\024\027\235\035\017\022\021\026\b \023\024\f\035\036\007\027\017\b \ \007\036\f\016\021\017\035\036\021\017\005 \027\026\004\017\021\036\035\ \034\027\024 )Tj 0.143 Tw T* (\r\024\030\024\f\035\026 \021\016\032\036\f\021\034 \f\024\004\036\021\026\ \027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\036\027\027\t\b \023\024)Tj 0 Tw (-)Tj -0.023 Tw T* [(\r\030\036\032\007\036\027\017\005 )0.6(\024\030\020\026\027\024\r )0.5(\002\030\033\001\027\024\005 )0.5(\023\024\035\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.688 0 Td [(\021\026\026, )0.6(\004\021\024 )0.5(\f\r\016)]TJ 0 Tw (-)Tj 0.066 Tw -16.688 -1.218 Td (\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\024\f\001\036\005 \n\024\013\027\024\f\021\034\033 \f\024\r\030\ \036\n\036\027\027\024\020\024 \024\030\031\032\017\016, )Tj 0.094 Tw T* (\026\022\021\017\r\027\t\n \023\030\017\n\036\027\036\027\017\036\n \r\030\ \t\r\027\t\b \023\024\030\026\032\026\033\013\017\b \220\035\036)Tj 0 Tw (-)Tj 0.241 Tw T* (\n\036\027\021\024\r, \n\026\027\036\r\030\036\027\027\024\f\021\034\033\ \r\036\007\036\027\017\016 \002\024\036\r\t\b \007\036\005\f\021\r\017\005\ )Tj -0.012 Tw T* ([4,5]. \217\026\027\036\027\017\016 \023\030\016\n\024\005 \022\017\001\022\ \017 \(\217\215\025\) \f\024\f\021\026\r\035\016\033\021 1\2265% )Tj 0.265 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (5\22612%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \r\024\036\027\027\t\b )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 546.5044 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 0 Tw 9 0 0 9 45.2263 537.5771 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (57)Tj ET endstream endobj 1360 0 obj [1369 0 R] endobj 1361 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-56-64)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 128.1163 695.3259 Tm [(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 )]TJ -2.072 -1.105 Td [(\220\n\005\002\005\013\n\225\004\016\r)10.1(\025\221 \224\025\024\025\234\n \224\005\n\022)-23.2(\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\r\n )]TJ 3.771 -1.105 Td [(\t\017\022)-23.3(\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\037)20(\n\024\022)-23.3(\030.\207.)]TJ 8.162 0 0 8.162 128.6618 633.484 Tm (2)Tj 0.023 Tw 14 0 0 14 133.2978 628.822 Tm [(, \235\002\016\017\n\020\025\b\022)-23.2(\021.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 228.2945 633.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 239.6151 628.822 Tm [(, \f\255\202\002\005\017\220\024\017\t\025\b\022)-23.2(\033)124(.\210.)]TJ 0 Tw 8.162 0 0 8.162 362.8777 633.484 Tm (3)Tj 5.83 0 0 5.83 70.8661 614.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 611.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \021\235)21(\032 \n\024\004\t\n \f)-31(.\f)-31(.\022)-23.3(\021\n\204\t\004\b\016\r)10.1(\025\013)10(\025\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\n\n \(\224.\ \007\025\b\217\221, \026)11(\004\005)-31(. 3 \003\021\037\031 )]TJ -0.331 -1.2 Td [(\n\024.\022)-23.3(\f)-30.9(.\f)-31(.\022)-23.3(\021\n\204\t\004\b\016\r)10.1(\025\013)10(\025, \202.\022)-23.3(1)69(, \013)62(.\025. \037)20(\005\017\016\t\025\013)10(\025\005\016\r, \235\025\016\r)10(\025\b\016\r\017\213 \025\255\020\017\016)-10(\026\200, 1)150(43)58(420, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 587.1527 Tm [(\210\n\020\n\017\020 \0231\210\031\006)42(\227 \253\007\235\030\003 \021\235)21(\032 \n\024\004\t\n \f)-30.9(.\f)-31(.\022)-23.3(\021\n\204\t\004\b\016\r)10.1(\025\013)10(\025\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\n\n \(\002\020\ .\022)-23.3(\001\b\004\026)21.1(\020\017\213, \202\b\020.\022)-23.2(1)211.9(1)69(, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\037)20(\005\017\016\t\025\013)10(\025\005\016\r, \235\025\016\r)10(\025\b\016\r\017\213 \025\255\020\017\016)-9.9(\026\200, 1)150(43)58(409, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 566.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 563.1528 Tm [(\210\n\020\n\017\020 \210\031\006\021\036)20(\227 \021\036 \253\021\235\004\202\f \n\024.\022)-23.3(\001.\235.\022)-23.2(\037)20(\n\005\025\b\017\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\ \n\n \(\002\020.\022)-23.3(\235\017\020\017\213 \215\004\005\r\n\212\025\b\016\r\017\213, \202.\022\ )-23.3(7)127(, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\235\025\016\r\b\017, 1)75(0)37(7)57(3)11(9)35(2, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf -0.025 Tw 9 0 0 9 119.0551 532.6489 Tm (\037\036\035\034: \032\020\016\032\020\240\031\023\020\023\017 \020\f\b\031\ \032\022\023\026 \031\n\020\016\020\025\022\t \200\022\032\r\032\b\022\007\ \027\024\n\031\235 \033\031\026\031\212\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\032\020\025\027\025\022\t\200 \033\032\t\026\031\235 \n\022\213\n\022 \(\ \206\004\202\) \025\020)Tj /Span<>> BDC ( )Tj EMC (\204\023\020\033\020\200 )Tj 0.116 Tw 0 -1.111 TD (\026\027\030\022\006\022\025\024\n\031\235 \204\021\020\n\r\020\006\022\022\ \(\230\215\230\) \024)Tj /Span<>> BDC ( )Tj EMC (\r\007\233\023\031\026 \030\022\203\203\027\032\027\025\006\022\032\031\021\ \020\025\025\031\b\031 \033\031\030\200\031\030\020 \033\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\032\027\030\027\f\027\025\022\005 \031\240\236\233\026\020 \031\ \033\027\032\020\006\022\022 )Tj 0.023 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\033\031\n\020\016\020\025\022\235 \n)Tj /Span<>> BDC ( )Tj EMC (\030\032\027\025\022\032\031\021\020\025\022\005 \n\f\027\023\007\020\023\ \031\007\025\013\200 \033\032\031\024\023\032\020\025\024\023\021 \023\020\ \016\020 \(\202\004\).)Tj 0.057 Tw 0 -1.111 TD (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\022\031\030 \024)Tj /Span<>> BDC ( )Tj EMC (\026\020\032\023\020 2023 \b\031\030\020 \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\027\n\020\240\032\017 2024 \b\031\030\020 \032\027\023\032\031\024\033\ \027\n\023\022\021\025\031 \022\016\r\007\027\025\013 \032\027\016\r\f\017\ )Tj 0 Tw (-)Tj 0.073 Tw 0 -1.111 TD (\023\020\023\013 \f\027\007\027\025\022\t \033\020\006\022\027\025\023\031\ \021 \024)Tj /Span<>> BDC ( )Tj EMC (\206\004\202 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (135\), \033\031\f\r\007\020\021\213\022\200 \204\023\020\033\025\r\005 \200\ \022\032\r\032\b\022\007\027\024\n\r\005 \033\031\026\031\212\017. \205\032\ \027\030\025\022\235 \021\031\016\032\020\024\023 )Tj 0.112 Tw T* (\024\031\024\023\020\021\022\f 34,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (4,2 \b\031\030\020 \(\031\023 21 \030\031)Tj /Span<>> BDC ( )Tj EMC (65 \f\027\023\). \004\031\f \021)Tj /Span<>> BDC ( )Tj EMC (99,2% \240\013\f \026\r\255\024\n\031\235, \021)Tj /Span<>> BDC ( )Tj EMC (0,8%)Tj /Span<>> BDC ( )Tj EMC (\227 \255\027\025\024\n\022\235. \211)Tj /Span<>> BDC ( )Tj EMC (1-\005 \b\032\r\033\033\r )Tj 0.093 Tw T* (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (93\) \021\031\213\f\022 \033\020\006\022\027\025\023\013 \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\r\023\032\022\240\032\005\213\022\025\025\013\026\022 \206\004\202\ . \211\031 2-\005 \b\032\r\033\033\r \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (42\) \021\031\213\f\022 \033\020\006\022\027\025\023\013 \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\240\032\005)Tj 0 Tw (-)Tj 0.089 Tw T* (\213\022\025\025\013\026\022 \206\004\202. \004\032\022\025\006\022\033\022\ \020\f\017\025\031\027 \032\020\016\030\027\f\027\025\022\027 \025\020)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\027 \b\032\r\033\033\013 \240\013\f\031 \031\240\r\024\ \f\031\021\f\027\025\031 \032\020\016\f\022\007\025\031\235 \200\022\032\ \r\032\b\022\007\027\024\n\031\235 )Tj -0.023 Tw T* (\023\020\n\023\022\n\031\235 \021)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\022 \r\n\020\016\020\025\025\013\200 \n\020\023\027\ \b\031\032\022\235. \206\027\023\032\031\024\033\027\n\023\022\021\025\031\ \022\016\r\007\027\025\013 \031\024\031\240\027\025\025\031\024\023\022\ \200\020\032\020\n\023\027\032\022\024\023\022\n \032\020\025\027\025\022\ \235, )Tj 0.153 Tw T* (\024\031\007\027\023\020\025\025\031\024\023\022 \033\031\021\032\027\255\ \030\027\025\022\235 \024)Tj /Span<>> BDC ( )Tj EMC (\030\032\r\b\022\026\022 \031\032\b\020\025\020\026\022 \022)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\023\027\026\020\026\022. \004\032\031\022\016\021\027\030\027\ \025\020 \031\006\027\025\n\020 \031\240\236\233\026\020 \021\013\033\031\ \f\025\027\025\025\013\200 )Tj 0.034 Tw T* (\031\033\027\032\020\006\022\235 \025\020)Tj /Span<>> BDC ( )Tj EMC [(\204\023\020\033\020\200 \026\027\030\022\006\022\025\024\n\031\235 \204\ \021\020\n\r\020\006\022\022, \024\032\031\n\022 \032\020\016\021\022\023\ \022\t )0.5(\031\024\f\031\255\025\027\025\022\235. \004\032\031\024\033\027\n\023\022\ \021\025\031, \024)]TJ /Span<>> BDC ( )Tj EMC (\r\007\020\024\023\022\027\026 \033\020\006\022)Tj 0 Tw (-)Tj 0.082 Tw 0 -1.111 TD (\027\025\023\031\021 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (39\), \022\026\027\005\212\022\200 \021\025\027\240\032\005\213\022\025\025\ \013\027 \032\020\025\027\025\022\t, \033\032\031\021\027\030\027\025\031\ \n\031\b\031\032\023\025\031\027 \022\024\024\f\027\030\031\021\020\025\ \022\027. \211)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\025\r\005 \b\032\r\033\033\r )Tj 0.083 Tw 0 -1.111 TD (\033\032\031\024\033\027\n\023\022\021\025\031\b\031 \022\024\024\f\027\030\ \031\021\020\025\022\t \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15\) \021\031\213\f\022 \033\020\006\022\027\025\023\013, \r)Tj /Span<>> BDC ( )Tj EMC (\n\031\023\031\032\013\200 \033\032\022\026\027\025\t\f\031\024\017 \020\ \n\023\022\021\025\031\027 \030\032\027\025\022\032\031\021\020\025\022\027\ )Tj 0.057 Tw T* (\033\032\027\024\020\n\032\020\f\017\025\031\b\031 \033\032\031\024\023\032\ \020\025\024\023\021\020. \205\f\027\030\r\027\023 \031\023\026\027\023\022\ \023\017, \007\023\031 \r)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\031\235 \b\032\r\033\033\013 \033\020\006\022\027\025\023\ \031\021 \206\004\202 \025\027 \240\013\f\022 \030\022\020\b\025\031)Tj 0 Tw (-)Tj 0.059 Tw T* [(\024\023\022\032\031\021\020\025\013 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC [(\033\027\032\021\022\007\025\013\200 )0.5(\230\215\230. \211)]TJ /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\r \024\032\020\021\025\027\025\022\t \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (24\) \021\031\213\f\022 \033\020\006\022\027\025\023\013, \n\031\023\031\ \032\013\026 \021\013\033\031\f\025\t\f\031\024\017 \024\023\020\025)Tj 0 Tw (-)Tj 0.146 Tw T* (\030\020\032\023\025\031\027 \240\022\f\020\023\027\032\020\f\017\025\031\ \027 \033\020\032\020\032\027\n\023\020\f\017\025\031\027 \030\032\027\025\ \022\032\031\021\020\025\022\027. \217\006\027\025\n\020 \204\203\203\027\ \n\023\022\021\025\031\024\023\022 \200\022\032\r\032\b\022\007\027\024\n\ \031\b\031 \f\027\007\027\025\022\t )Tj 0.105 Tw T* (\033\032\031\022\016\021\031\030\022\f\020\024\017 \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\020\025\022\022 \022\016\r\007\027\025\022\t \240\031\ \f\027\021\031\b\031 \024\022\025\030\032\031\026\020 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\026\013\021\020\025\022\022 \030\032\027\025\020\255\027\235\ , \033\031)Tj /Span<>> BDC ( )Tj EMC (\021\022\016\r\020\f\017\025\031-\020\025\020\f\031)Tj 0 Tw (-)Tj 0.154 Tw T* (\b\031\021\031\235 \213\n\020\f\027 \(\211\003\237\) \240\031\f\022, \032\ \027\016\r\f\017\023\020\023\031\021 \n\f\022\025\022\n\031-\240\022\031\ \200\022\026\022\007\027\024\n\022\200 \033\031\n\020\016\020\023\027\f\027\ \235 \021)Tj /Span<>> BDC ( )Tj EMC (1-\027 \022)Tj /Span<>> BDC ( )Tj EMC (3-\027 \024\r\023\n\022. \217\006\027\025\022\023\017 )Tj 0.125 Tw T* (\032\027\016\r\f\017\023\020\023\013 \f\027\007\027\025\022\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\027\027 \033\032\031\030\031\f\255\022\023\027\f\017\025\031\026\ \021\032\027\026\027\025\025\031\026 \033\032\031\026\027\255\r\023\n\027\ \025\027 \033\032\027\030\024\023\020\021\f\t\f\031\024\017 \021\031\016\ \026\031\255\025\013\026, )Tj 0.023 Tw T* (\021)Tj /Span<>> BDC ( )Tj EMC (\024\021\t\016\022 \024)Tj /Span<>> BDC ( )Tj EMC (\n\031\032\031\023\n\022\026 \024\032\031\n\031\026 \033\032\027\240\013\ \021\020\025\022\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\230\215\230.)Tj 0.11 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \022\024\024\f\027\030\r\027\026\013\ \027 \b\032\r\033\033\013 \240\013\f\022 \024\031\033\031\024\023\020\021\ \022\026\013 \033\031)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\022\016\022\032\r\027\026\013\026 \033\031\n\020\016\020\023\ \027\f\t\026. \001\020)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\021\022\007\025\013\200 \230\215\230 )Tj 0.143 Tw 0 -1.111 TD [(\r\213\022\021\020\025\022\027 )0.6(\206\004\202 )0.5(\033\032\022\026\027\025\t\f\031\024\017 )0.6(\021)]TJ /Span<>> BDC ( )Tj EMC 12.903 0 Td [(28,5-30,2% )0.5(\025\020\240\f\005\030\027\025\022\235. )0.6(\206\027\016\027\n\006\022\t )0.6(\033\032\t\026\031\235 )0.6(\n\022\213\n\022 )0.5(\240\013\f\020 )0.5(\033\032\022\026\027\025\027\025\020 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 29.674 0 Td (57,9% )Tj 0.331 Tw -42.576 -1.111 Td (\007\020\212\027 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\021\025\r\023\032\022\240\032\005\213\022\025\025\013\200 \032\020\025\027\ \025\022\t\200 \(69,8%\) \033\031)Tj /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\027\025\022\005 \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\240\032\005\213\022\025\025\013\026\022 \032\020\025\027\025\ \022\t\026\022 \(11,9%\), )Tj 0.243 Tw T* (\033\032\022)Tj /Span<>> BDC ( )Tj EMC (p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \001\020)Tj /Span<>> BDC ( )Tj EMC (\204\023\020\033\027 \024\033\027\006\022\020\f\022\016\022\032\031\021\020\ \025\025\031\235 \026\027\030\022\006\022\025\024\n\031\235 \033\031\026\ \031\212\022, \021)Tj /Span<>> BDC ( )Tj EMC (11,8% \024\f\r\007\020\027\021 \023\020\n\255\027 \021\013\033\031\f\025\ \t\f\022 )Tj 0.16 Tw T* (\r\213\022\021\020\025\022\027 \206\004\202. \206\027\016\027\n\006\022\t\ \033\031)Tj /Span<>> BDC ( )Tj EMC [(\023\022\033\r \031\033\027\032\020\006\022\022 \216\020\032\023\026\020\ \025\020 )0.5(\033\031\023\032\027\240\031\021\020\f\020\024\017 \021)]TJ /Span<>> BDC ( )Tj EMC (21,5% \024\f\r\007\020\027\021, \020)Tj /Span<>> BDC ( )Tj EMC (\032\027\n\031\025\024\023\032\r\n\006\022\t )Tj 0.014 Tw T* (\n\031\f\031\024\023\031\026\013)Tj /Span<>> BDC ( )Tj EMC 4.946 0 Td [(\227 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 1.959 0 Td [(29% )0.5(\025\020\240\f\005\030\027\025\022\235. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 8.383 0 Td [(35,7% )0.5(\n\f\022\025\022\007\027\024\n\022\200 )0.6(\025\020\240\f\005\030\027\025\022\235 )0.6(\033\031\023\032\027\240\031\021\020\f\020\024\017 )0.5(\032\027\016\027\n\006\022\t )0.5(\033\032\t\026\031\235 )0.5(\n\022\213\n\022 )]TJ 0.145 Tw -15.289 -1.111 Td (\033\032\022)Tj /Span<>> BDC ( )Tj EMC [(\021\025\027\240\032\005\213\022\025\025\013\200 \032\020\025\027\025\022\ \t\200 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 13.54 0 Td [(\024\021\t\016\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\033\032\031\033\r\212\027\025\025\013\026\022 )0.5(\033\031\021\032\027\255\030\027\025\022\t\026\022 \025\020)]TJ /Span<>> BDC ( )Tj EMC (\033\032\027\030\013\030\r\212\022\200 \204\023\020\033\020\200, \007\023\ \031 \240\013\f\031 )Tj 0.117 Tw -13.54 -1.111 Td [(\031\240\r\024\f\031\021\f\027\025\031 \026\027\030\022\n\031-\023\020\n\ \023\022\007\027\024\n\031\235 )0.5(\031\240\024\023\020\025\031\021\n\031\235. \216\025\031\235\025\031-\025\ \027\n\032\031\023\022\007\027\024\n\022\027 \022\016\026\027\025\027\025\ \022\t \202\004 \016\020\032\027\b\022\024\023\032\022\032\031\021\020\025\ \013 )]TJ -0.018 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC (2-\027 \024\r\023\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (12,5% \025\020\240\f\005\030\027\025\022\235, \025\020)Tj /Span<>> BDC ( )Tj EMC (3-\027 \024\r\023\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\027\027)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (62,5% \024\f\r\007\020\027\021 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\024\023\020\025\030\020\032\023\025\031\026 \240\022\f\020\023\027\032\020\ \f\017\025\031\026 )Tj 0.171 Tw 0 -1.111 TD [(\033\020\032\020\032\027\n\023\020\f\017\025\031\026 )0.5(\030\032\027\025\022\032\031\021\020\025\022\022. \211)]TJ /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\025\031\235 \b\032\r\033\033\027, \b\030\027 \033\032\ \022\026\027\025\t\f\020\024\017 \026\027\023\031\030\022\n\020 \020\n\023\ \022\021\025\031\b\031 \030\032\027\025\022\032\031\021\020\025\022\t )Tj 0.181 Tw 0 -1.111 TD (\033\032\027\024\020\n\032\020\f\017\025\031\b\031 \033\032\031\024\023\032\ \020\025\024\023\021\020, \r\n\020\016\020\025\025\013\027 \031\024\f\031\ \255\025\027\025\022\t \025\027 \025\020\240\f\005\030\020\f\022\024\017\ . \001\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\020\025\022\022 \032\027\016\r\f\017\023\020\023\031\ \021 \033\032\031)Tj 0 Tw (-)Tj 0.162 Tw T* [(\021\027\030\233\025\025\031\b\031 )0.5(\022\024\024\f\027\030\031\021\020\025\022\t )0.5(\r\024\023\020\025\031\021\f\027\025\031, )0.5(\007\023\031 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC [(\204\023\020\033\027 )0.5(\n\021\020\f\022\203\022\006\022\032\031\021\020\025\025\031\235 )0.5(\026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\212\022 )0.5(\021\013\033\031\f\025\t)]TJ 0 Tw (-)Tj 0.119 Tw T* (\f\022\024\017 \031\033\027\032\020\023\022\021\025\013\027 \021\026\027\ \213\020\023\027\f\017\024\023\021\020 \033\031)Tj /Span<>> BDC ( )Tj EMC (\255\022\016\025\027\025\025\013\026 \033\031\n\020\016\020\025\022\t\026\ , \031\240\r\024\f\031\021\f\027\025\025\013\026 \033\032\031\025\022\n\020\ \005\212\022\026 \200\020\032\020\n\023\027\032\031\026 )Tj 0.051 Tw T* [(\032\020\025\027\025\022\t )0.6(\255\022\021\031\023\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 8.029 0 Td [(\023\020\016\020. )0.6(\230\023\020\033 )0.6(\024\033\027\006\022\020\f\022\016\022\032\031\021\020\025\025\031\235 )0.6(\026\027\030\022\006\022\025\024\n\031\235 )0.7(\033\031\026\031\212\022, )0.6(\031\024\025\020\212\233\025\025\013\235 )0.6(\024\031\031\023\021\027\023\024\023\021\r\005\212\022\026 )]TJ 0.012 Tw -8.029 -1.111 Td (\031\240\031\032\r\030\031\021\020\025\022\027\026 \022)Tj /Span<>> BDC ( )Tj EMC (\024\033\027\006\022\020\f\022\024\023\020\026\022, \033\031\016\021\031\ \f\t\027\023 \024\n\031\032\032\027\n\023\022\032\031\021\020\023\017 \n\ \031\025\023\032\031\f\017 \033\031\021\032\027\255\030\027\025\022\235 \ \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\206\004\202, \023\027\026 \024\020\026\013\026 )Tj 0.023 Tw 0 -1.111 TD (\024\025\022\016\022\023\017 \032\022\024\n \032\020\016\021\022\023\022\ \t \b\025\031\235\025\031-\024\027\033\023\022\007\027\024\n\022\200 \031\ \024\f\031\255\025\027\025\022\235.)Tj 0.089 Tw 0 -1.111 TD (\207\003\202\035\224\232\036\001\002\036: \032\027\016\r\f\017\023\020\023\ \013 \031\n\020\016\020\025\022\t \204\023\020\033\025\031\235 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(\004\036\f\021\r\026 \032\017\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\017 \007\036\030\032\026\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \030\026\002\024\021\036 )Tj 0.072 Tw T* (\017\n\036\036\021\f\016 \024\020\030\026\027\017\004\036\027\017\036 \017\ \f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \026\r\021\024\030\t \023\024\035\031)Tj 0 Tw (-)Tj 0.013 Tw T* [(\004\017\035\017 )0.5(\035\024\032\027\024\024\021\030\017\006\026\021\036\035\034\027\t\005 )0.7(\030\036\031\035\034\021\026\021 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 16.865 0 Td [(\007\026\027\027\t\n )0.5(\022\030\017)]TJ 0 Tw (-)Tj -0.031 Tw -16.865 -1.218 Td (\021\036\030\017\016\n. \200\024\n\024\032\027\024, \f\021\024\017\035\024\ \026\007\031\n\026\021\034\f\016 \024\002 \017\f\023\024\035\034\024\r\ \026)Tj 0 Tw (-)Tj -0.021 Tw T* [(\027\017\017 )0.5(\f\023\036\006\017\235\017\004\036\f\022\024\020\024 )0.6(\024\023\030\024\f\027\017\022\026)]TJ /Span<>> BDC ( )Tj EMC 13.394 0 Td [(\227 )0.5(pouch )0.5(d)17(y)-13(sfunc)-15.9(t)-32(ion )]TJ 0.062 Tw -13.394 -1.218 Td [(scor)-24(e, )0.5(\007\026\032\036, )0.5(\027\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.577 0 Td [(\024\021\f\031\021\f\021\r\017\036 )0.6(\r\026\035\017\007\026\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.207 0 Td (\027\026)Tj 0 Tw (-)Tj 0.207 Tw -20.784 -1.218 Td (\001\036\005 \f\021\030\026\027\036, \027\024 \023\024\022\026\t\r\026\033\ \013\017\005 \023\036\030\f\024\027\017\235\017\006\017\030\024\r\026\027\ )Tj 0 Tw (-)Tj 0.112 Tw T* (\027\024\036 \022\026\004\036\f\021\r\024 \032\017\027\017. \221\026\022\ \032\036 \n\024\032\027\024 \002\t\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 )Tj -0.024 Tw T* (\024\023\030\024\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\002\024\030\026 \n\026\021\036\030\017\026\035\026 \026\007\026\ \021\034 \007\r\026 \r\024\023\030\024\f\026)Tj /Span<>> BDC ( )Tj EMC (\227 \b\024)Tj 0 Tw (-)Tj 0.058 Tw T* (\021\036\035\017 \002\t \024\027\017 \023\030\024\005\021\017 \007\026\027\ \027\t\005 \b\017\030\031\030\020\017\004\036\f\022\017\005 \023\031\021\ \034 \036\013\036 )Tj 0.114 Tw T* (\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\024\r\036\021\024\r\026\035\017 \035\017 \024\027\017 \r\024\f\ \f\021\026\027\024\r\017\021\036\035\034\027\031\033 \024\023\036)Tj 0 Tw (-)Tj 0.039 Tw T* (\030\026\006\017\033 \007\030\031\020\017\n \023\026\006\017\036\027\021\ \026\n? \211\022\026\026\027\027\t\036 \r\024\023\030\024\f\t \n\024\020\ \035\017 )Tj -0.012 Tw 23.244 20.703 Td (\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\021\034 \017\f\ \021\017\027\027\031\033 \024\006\036\027\022\031 \023\026\006\017\036\027\ \021\024\n \022\026)Tj 0 Tw (-)Tj 0.169 Tw T* (\004\036\f\021\r\026 \032\017\027\017, \024\f\024\002\036\027\027\024 \023\ \030\017 \027\036\031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\ \027\t\b )Tj -0.01 Tw T* [(\023\024\022\026\026\021\036\035\016\b )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n )0.5(\007\030\031\020\017\b \001\022\026\035 )0.5(\017\035\017 \024\023\030\024\f\027\017\022\024\r. )]TJ -0.04 Tw T* (\212\035\016 \002\024\035\034\001\017\027\f\021\r\026 \023\026\006\017\036\ \027\021\024\r \031\b\031\007\001\036\027\017\036 \235\031\027\022\006\017\ \017 \007\036\030)Tj 0 Tw (-)Tj -0.011 Tw T* (\032\026\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\036\022\024\021\024\030\t\b \017\027\007\017\022\ \026\021\024\030\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\031 )Tj 0.068 Tw T* [(SF-36 \027\036 \016\r\035\016\036\021\f\016 )0.5(\023\024\022\026\026\027\017\036\n \007\035\016 \r\024\r\030\026\021\026\ \022)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\021\024)Tj 0 Tw (-)Tj 0.062 Tw T* (\016\027\027\024\005 \017\035\036\024\f\021\024\n\036, \026)Tj /Span<>> BDC ( )Tj EMC (\035\017\001\034 \031\f\017\035\017\r\026\036\021 \026\007\026\023\021\026\ \006\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\027\024)Tj 0 Tw (-)Tj 0.058 Tw T* (\r\t\n \031\f\035\024\r\017\016\n \032\017\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\030\r\031\026\030\024\n. \221\026\022\017\n \024\002\030\026\ \024\n, )Tj 0.16 Tw T* (\026\022\035\033\004\036\027\017\036, \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n\031 \023\030\017\b\024\007\016\021 \026\r\021\ \024\030\t, \004\021\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036)Tj 0 Tw (-)Tj 0.082 Tw T* [(\004\036\027\017\036\n )0.5(\r\030\036\n\036\027\017 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 7.902 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\023\030\024\017\f\b\024\007\017\021 )0.5(\031\b\031\007\001\036\027\017\036 )]TJ -0.003 Tw -7.902 -1.218 Td [(\023\024\022\026\026\021\036\035\036\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 \200\036\022\f\027\036\030\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\027\017\032\036\027\017\036 )0.5(\022\026\004\036\f\021\r\026 )]TJ 0.188 Tw T* [(\032\017\027\017 )0.6(\f\035\036\007\031\036\021 )0.5(\r\024\f\023\030\017\027\017\n\026\021\034 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 13.732 0 Td [(\024\f\021\024\030\024\032\027\024\f\021\034\033, )0.6(\023\024)]TJ 0 Tw (-)Tj 0.027 Tw -13.732 -1.218 Td (\f\022\024\035\034\022\031 \024\027\024 \n\024\032\036\021 \f\023\030\024\ \r\024\006\017\030\024\r\026\021\034 \030\024\f\021 \024\021\030\017\006\ \026\021\036\035\034)Tj 0 Tw (-)Tj 0.023 Tw T* (\027\024\020\024 \024\021\027\024\001\036\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\002\027\024\005 \024\023\036\030\026\006\017\017. \221\036\ \n \027\036 \n\036\027\036\036, )Tj 0.272 Tw T* [(\026\r\021\024\030\t )0.5(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 )0.6(\024\021\007\026\035\036\027\027\t\036 )0.6(\235\031\027\022\006\017\024)]TJ 0 Tw (-)Tj 0.171 Tw T* [(\027\026\035\034\027\t\036 )0.5(\030\036\031\035\034\021\026\021\t )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\022\030\026\005\027\036 )0.5(\f\035\024\032\027\024\005 \022\024\020\024\030\021\t )0.5(\023\026)]TJ 0 Tw (-)Tj 0.351 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\021\024\027\022\024\022\017\001\036\004\027\t\n )0.5(\030\036\036\030\r\031\026\030\024\n, \027\036\f\n\024\021\030\016 )]TJ 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036 \027\036\f\023\036\006\017\ \235\017\004\036\f\022\017\b \024\023\030\024\f\027\017\022\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.7271 56.0378 Tm (55)Tj ET q 0 g /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC1 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 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Et)-32(iol)30(o)-16(g)16(y and mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC (fecal incon)Tj 0 Tw (-)Tj 0.006 Tc -0.006 Tw -1.296 -1.25 Td [(t)-31.7(inence. )]TJ /T1_3 1 Tf 0.349 Tw 4.002 0 Td (Diseases of)Tj /Span<>> BDC ( )Tj EMC [(the Colon and R)21.3(ectum.)]TJ /T1_0 1 Tf [( 1993;36\(1\):77\22697.)6( )]TJ 0 Tc 0 Tw -4.002 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/BF02050307)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.53 Tw -1.847 -1.25 Td [(9)0.5(.)]TJ /Span<>> BDC 0.825 0 Td ( )Tj EMC 0.514 0 Td [(\202)0.5(\004)0.6(\022)0.5(\026)0.5(\f)0.5(\024)0.5(\r)]TJ /Span<>> BDC 3.46 0 Td ( )Tj EMC [(\222)0.5(.)0.5(\230)0.5(.)0.6(,)0.5( \200)0.6(\026)0.5(\030)0.5(\007)0.5(\026)0.5(\027)0.5(\016)0.6(\027)]TJ /Span<>> BDC 7.577 0 Td ( )Tj EMC [(\202)0.5(.)0.5(\200)0.6(.)0.5(,)0.5( \207)0.5(\017)0.5(\027)0.5(\027)0.6(\026)0.5(\021)0.5(\035)0.5(\017)]TJ /Span<>> BDC 7.552 0 Td ( )Tj EMC [(\231)0.5(.)0.5(\202)0.5(.)0.6(,)0.5( \017)]TJ /Span<>> BDC 4.308 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.5(\r)0.5(\021)0.6(.)14.9( )]TJ 0 Tc 0.031 Tw -24.237 -1.25 Td (\222\030\026\r\027\017\021\036\035\034\027\026\016 \024\006\036\027\022\026\ \022\026\004\036\f\021\r\026 \032\017\027\017 \023\026\006\017\036\027\ \021\024\r, \024\023\036\030\017\030\024\r\026\027\027\t\b )Tj 0.007 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \016\r\036\027\027\024\020\024 \022\024\035\017\021\ \026. )Tj /T1_3 1 Tf (\225\022\032\r\032\b\022\t. \234\r\032\025\020\f \022\026. \001.\002.)Tj /Span<>> BDC ( )Tj EMC (\004\022\032\031\b\031\021\020)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2020;7:18\22624. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2009.02163.x)Tj 0 0 0 1 k /GS1 gs 0.298 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\n\017\030\007\032\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \206\024\030\016\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \025\024\030\001\031\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\230., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.183 Tw -1.796 -1.25 Td (\215\024\023\031\035\016\006\017\024\027\027\t\036 \023\024\022\026\026\ \021\036\035\017 \022\026\004\036\f\021\r\026 \032\017\027\017 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\031 SF-36 )Tj 0.013 Tc 0.469 Tw T* [(\(\030\036\031\035\034\021\026\021\t \n\027\024\020\024\006\036\027\021\ \030\024\r\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \022\026\ \004\036\f\021\r\026 \032\017\027\017)13( )]TJ 0 Tc 0 Tw T* (\253\204\230\217\202\240\273\). )Tj /T1_3 1 Tf 0.288 Tw 5.319 0 Td (\001\020\r\007\025\031-\033\032\020\n\023\022\007\027\024\n\020\t \032\027\ \021\026\020\023\031\f\031\b\022\t)Tj /T1_0 1 Tf (. 2008;1:36\22648. )Tj 0 Tw -5.319 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.14412/1995-4484-2008-852)Tj 0 0 0 1 k /GS1 gs 0.228 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)60(ul)16(chinsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(N, Do)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(I, Halper)-14.9(n)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(l)30(ongi)-24(tudinal stud)17.1(y )]TJ 0.203 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(qual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife and func)-16(t)-32(ional outcome of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-24(t)-13(h ul)16(cer)]TJ 0 Tw 27.286 0 Td (-)Tj 0.346 Tw -27.286 -1.25 Td [(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is af)-28(ter p)25(r)-32(o)-16(c)-16(t)17(o)-16(colec)-15.9(t)17(omy wi)-24(t)-13(h ileal pouch-anal anas)]TJ 0 Tw (-)Tj T* [(t)17(omosis. )]TJ /T1_3 1 Tf 0.249 Tw 3.891 0 Td (Diseases of)Tj /Span<>> BDC ( )Tj EMC [(the Colon and R)21(ectum)]TJ /T1_0 1 Tf (. 2010;53\(6\):866\226873. )Tj 0 Tw -3.891 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1463-1318.2009.02163.x)Tj 0 0 0 1 k /GS1 gs 0.116 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ander)-10(sson)]TJ /Span<>> BDC ( )Tj EMC [(T, L)35(unde)]TJ /Span<>> BDC ( )Tj EMC (OC, Johnson)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m func)-16(t)-31.9(ional )]TJ 0.104 Tw -1.796 -1.25 Td [(outcome and qual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife af)-27.9(ter r)-24(est)17(or)-33(a)15(t)-31.9(i)-16(ve p)25(r)-32(o)-16(c)-16(t)17(o)-16(colec)-15.9(t)17(omy wi)-24(t)-13(h )]TJ -0.043 Tw T* [(ileo-anal anast)17(omosis for col)-30.9(i)-24(t)-32(is. )]TJ /T1_3 1 Tf (Colorectal Disease.)Tj /T1_0 1 Tf ( 2011;13\(4\):431\226)Tj 0.023 Tw T* [(437. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2009.02163.x)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 359.4899 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.265 Tw 8 0 0 8 70.8661 346.6552 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(ar)-24(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(A)16(G, Nicholls)]TJ /Span<>> BDC ( )Tj EMC [(RJ. P)35(r)-32(o)-16(c)-15.9(t)17(o)-16(colec)-16(t)17(omy wi)-24(t)-12.9(hout ileost)17.1(omy for )]TJ 0.004 Tc 0.349 Tw -1.296 -1.25 Td [(ul)16.1(cer)-32.9(a)15(t)-31.9(i)-16(ve col)-30.9(i)-23.9(t)-32(is. )]TJ /T1_3 1 Tf [(Br)-36.9(itish Medical Jour)-14(nal.)]TJ /T1_0 1 Tf [( 1978;2\(6130\):85\22688.)3.9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/bmj.2.6130.85)Tj 0 0 0 1 k /GS1 gs 0.218 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC (S.I., Sushkov)Tj /Span<>> BDC ( )Tj EMC [(O.I., K)25(ul)-31(ikov)]TJ /Span<>> BDC ( )Tj EMC [(A.E., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(pl)-30.9(ica)15(t)-32(ions )]TJ 0.115 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic ileal pouch in p)32(a)14.9(t)-31.9(ients oper)-33(a)15(ted on for ul)16(cer)-33(a)15(t)-31.9(i)-16(ve col)-31(i)-24(t)-32(is. )]TJ /T1_3 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.023 Tw (. 2017;61:73a. \(in Russ.\).)Tj 0.155 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)20(a)-24(zio)]TJ /Span<>> BDC ( )Tj EMC 2.478 0 Td [(V.W., )0.6(Kir)-33(an )0.5(R.P., )0.6(R)13(emzi)]TJ /Span<>> BDC ( )Tj EMC 9.873 0 Td [(F.H. )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.235 0 Td [(al. )0.6(Ileal )0.5(pouch )0.6(anal )0.5(anas)]TJ 0 Tw (-)Tj 0.149 Tw -16.882 -1.25 Td [(t)17(omosis: anal)35(y)-12.9(sis of)]TJ /Span<>> BDC ( )Tj EMC [(outcome and qual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-30.9(ife in 3707 p)32(a)15(t)-32(ients. )]TJ 0.157 Tw T* (Annals of)Tj /Span<>> BDC ( )Tj EMC [(Sur)-31.9(ger)-24(y. 2013. V)29(ol. 257 \(4\). P. 679\226685. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* [(SL)-35(A.0b013e31827d99a2)]TJ 0 0 0 1 k /GS1 gs 0.037 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(ashnikov)]TJ /Span<>> BDC ( )Tj EMC [(V.N., A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., Bol)-31(ikhov)]TJ /Span<>> BDC ( )Tj EMC [(K.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-37(i)]TJ 0 Tw (-)Tj 0.298 Tw -1.296 -1.25 Td [(mar)-24(y )0.5(and )0.5(second)42(ar)-24(y )0.5(ileal )0.6(pouch for)-15.9(ma)15(t)-32(ion )0.5(in )0.5(ul)16(cer)-33(a)15(t)-32(i)-16(ve )0.6(col)-31(i)-24(t)-32(is. )]TJ /T1_3 1 Tf 0.008 Tc 0.349 Tw T* [(R)22.4(ussi)0.5(an J)0.5(our)-13.6(na)0.5(l of)]TJ /Span<>> BDC 8.049 0 Td ( )Tj EMC [(G)0.5(astro)0.5(entero)0.5(logy, Hepat)0.5(ology,)0.5( Col)0.5(op)46.4(roc)0.5(tology)0.5(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 19.588 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (2014;6:73\22677. \(in Russ.\).)Tj 0.053 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(ovegr)-32(ove)]TJ /Span<>> BDC ( )Tj EMC 4.363 0 Td [(RE, )0.6(F)20(a)-24(zio)]TJ /Span<>> BDC ( )Tj EMC 3.857 0 Td [(VW, )0.5(R)13(emzi)]TJ /Span<>> BDC ( )Tj EMC 4.36 0 Td [(FH, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.624 0 Td [(al. )0.6(Devel)30(opment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.913 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 0.748 0 Td (pouch )Tj 0.009 Tc 0.35 Tw -25.162 -1.25 Td [(func)-15.9(t)-32(ional )0.6(scor)-24(e )0.6(foll)30(o)-14(wing )0.6(r)-24(est)17(or)-33(a)15(t)-32(i)-16(ve )0.5(p)25(r)-32(o)-16(c)-16(t)17.1(o)-16(colec)-16(t)17(omy. )]TJ /T1_3 1 Tf -0.009 Tw 24.975 0 Td [(Br)-37(itish)9( )]TJ 0 Tc 0.023 Tw -24.975 -1.25 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y)]TJ /T1_0 1 Tf [(. 2010. V)29(ol. 97 \(6\). P. 945\226951.10.1002/bjs.7021)]TJ -0.036 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hahnl)30(oser)]TJ /Span<>> BDC ( )Tj EMC [(D, P)30(ember)-22(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(JH, W)20(olf)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(BG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(ef)-56(fec)-15.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(geing on )]TJ -0.021 Tw -1.296 -1.25 Td [(func)-16(t)-32(ion and qual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-30.9(ife in ileal pouch p)32(a)15(t)-32(ients. )]TJ /T1_3 1 Tf (Annals of)Tj /Span<>> BDC ( )Tj EMC [(Surg)12(er)-43(y.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2004;240\(4\):615\226621. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.sl)-16(a.0000141157.32234.9d)]TJ 0 0 0 1 k /GS1 gs 0.289 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)12(ar)-24(e)]TJ /Span<>> BDC ( )Tj EMC 2.482 0 Td [(JE, )0.5(S)-16(her)-23.9(bour)-15(ne)]TJ /Span<>> BDC ( )Tj EMC 6.8 0 Td [(CD. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.762 0 Td [(MOS )0.5(36-i)-24(tem )0.5(shor)-21.9(t-for)-16(m )0.5(heal)56(t)-13(h )]TJ 0.022 Tw -14.34 -1.25 Td [(sur)-32(ve)-10.9(y \(SF-36\). I. Conceptual fr)-32.9(amew)-14(or)-23.9(k and i)-24(tem selec)-16(t)-31.9(ion. )]TJ /T1_3 1 Tf 0 Tw (Medical )Tj 29.055 26.25 Td (Care.)Tj /T1_0 1 Tf 0.023 Tw ( 1992;30\(6\):473\226483.)Tj 0.12 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)22(e)-18(xner)]TJ /Span<>> BDC ( )Tj EMC [(SD, Jor)-32(ge)]TJ /Span<>> BDC ( )Tj EMC [(JM. Et)-32(iol)30(o)-16(g)16(y and mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC (fecal incon)Tj 0 Tw (-)Tj 0.006 Tc -0.006 Tw -1.296 -1.25 Td [(t)-31.7(inence. )]TJ /T1_3 1 Tf 0.349 Tw 4.002 0 Td (Diseases of)Tj /Span<>> BDC ( )Tj EMC [(the Colon and R)21.3(ectum.)]TJ /T1_0 1 Tf [( 1993;36\(1\):77\22697.)6( )]TJ 0 Tc 0 Tw -4.002 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/BF02050307)Tj 0 0 0 1 k /GS1 gs 0.089 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., V)25(ar)-24(d)42(any)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Binna)15(tl)-31(i S)-16(h.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve )]TJ 0.106 Tw -1.296 -1.25 Td [(assess)26(ment of)]TJ /Span<>> BDC ( )Tj EMC [(qual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife in p)32(a)15(t)-32(ients oper)-32.9(a)15(ted on for ul)16.1(cer)-33(a)15(t)-32(i)-16(ve )]TJ 0 Tw T* [(col)-31(i)-23.9(t)-32(is. )]TJ /T1_3 1 Tf 0.03 Tw 3.141 0 Td [(Surg)12(er)-43(y. Jour)-13.9(nal named af)-45.9(ter N.I.)]TJ /Span<>> BDC ( )Tj EMC (Pirogov.)Tj /T1_0 1 Tf ( 2020;7:18\22624. \(in )Tj 0.023 Tw -3.141 -1.25 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2009.02163.x)Tj 0 0 0 1 k /GS1 gs 0.022 Tc 0.799 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.885 0 Td [(Amir)-24.1(d)16.8(zhanov)-15.1(a)]TJ /Span<>> BDC ( )Tj EMC [(V.N., Gor)-24.2(y)21.9(a)-17.1(chev)]TJ /Span<>> BDC ( )Tj EMC [(D.V., K)24.9(or)-10.1(shunov)]TJ /Span<>> BDC ( )Tj EMC [(N.I.,)22( )]TJ 0 Tc 0.3 Tw -1.885 -1.25 Td [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(opul)-15.9(a)15(t)-32(ion indica)15(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(qual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife a)-17(ccor)-24(ding t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.333 Tw T* [(SF-36 quest)-32(ionnair)-23.9(e \(r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he mul)56(t)-32(icenter )0.5(MIRA)16(GE stud)17(y\). )]TJ /T1_3 1 Tf 0.311 Tw T* [(Scientif)-42.9(ic and Practical Rheumatology.)]TJ /T1_0 1 Tf ( 2008;1:36\22648. \(in Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.14412/1995-4484-2008-852)Tj 0 0 0 1 k /GS1 gs 0.228 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)60(ul)16(chinsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(N, Do)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(I, Halper)-14.9(n)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(l)30(ongi)-24(tudinal stud)17.1(y )]TJ 0.203 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(qual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife and func)-16(t)-32(ional outcome of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-24(t)-13(h ul)16(cer)]TJ 0 Tw 27.286 0 Td (-)Tj 0.346 Tw -27.286 -1.25 Td [(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is af)-28(ter p)25(r)-32(o)-16(c)-16(t)17(o)-16(colec)-15.9(t)17(omy wi)-24(t)-13(h ileal pouch-anal anas)]TJ 0 Tw (-)Tj T* [(t)17(omosis. )]TJ /T1_3 1 Tf 0.249 Tw 3.891 0 Td (Diseases of)Tj /Span<>> BDC ( )Tj EMC [(the Colon and R)21(ectum)]TJ /T1_0 1 Tf (. 2010;53\(6\):866\226873. )Tj 0 Tw -3.891 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1463-1318.2009.02163.x)Tj 0 0 0 1 k /GS1 gs 0.116 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ander)-10(sson)]TJ /Span<>> BDC ( )Tj EMC [(T, L)35(unde)]TJ /Span<>> BDC ( )Tj EMC (OC, Johnson)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35(ong-ter)-15.9(m func)-16(t)-31.9(ional )]TJ 0.104 Tw -1.796 -1.25 Td [(outcome and qual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife af)-27.9(ter r)-24(est)17(or)-33(a)15(t)-31.9(i)-16(ve p)25(r)-32(o)-16(c)-16(t)17(o)-16(colec)-15.9(t)17(omy wi)-24(t)-13(h )]TJ -0.043 Tw T* [(ileo-anal anast)17(omosis for col)-30.9(i)-24(t)-32(is. )]TJ /T1_3 1 Tf (Colorectal Disease.)Tj /T1_0 1 Tf ( 2011;13\(4\):431\226)Tj 0.023 Tw T* [(437. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2009.02163.x)Tj /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1402 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ulcer)21(ativ)12(e colitis)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.175 Tw 10 0 0 10 42.5197 724.8299 Tm [(\200 \007\030\031\020\024\n \022\024\020\024\030\021\027\024\n \026\027\026\ \035\017\036 T)60(ul)16(chinsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC (H. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.029 Tw 0 -1.218 TD (\(2010 \020.\) \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\005 \024\006\036\027\022\024\005 \022\026\ \004\036\f\021\r\026 \032\017\027\017 \004\036\030\036 )Tj 0.126 Tw T* (60 \017)Tj /Span<>> BDC ( )Tj EMC (133 \n\036\f\016\006\026 \023\024\f\035\036 \026\022\030\t\021\017\016 \ \f\021\024\n\t \f\024\024\002\013\026\035\024\f\034 )Tj 0.099 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\017 \f\021\026\002\017\035\034\027\t\b \ \235\031\027\022\006\017\024\027\026\035\034\027\t\b \017\f\b\024\007\024\ \r, )Tj 0.088 Tw T* (\024\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \007\024\n\036\027\024\r SF-36 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)0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.723 0 Td [(\021\036\004\036\027\017\036\n)20( )]TJ 0.329 Tw -18.119 -1.218 Td [(\r\030\036\n\036\027\017 )0.5(\017\n\036\036\021 )0.5(\021\036\027\007\036\027\006\017\033 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 13.672 0 Td [(\f\027\017\032\036\027\017\033. )0.5(\210\007\027\026\022\024)20( )]TJ 0.209 Tw -13.672 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \r\026\017\n\024\f\r\016\017 \220\ \021\017\b \017\n\036\027\036\027\017\005 \r\t\r\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.234 Tw T* [(\007\t )0.5(\027\036\024\007\027\024\027\026\004\027\t. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 9.714 0 Td [(\017\021\024\020\036 )0.6(\027\026\001\036\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016)20( )]TJ 0.166 Tw -9.714 -1.218 Td [(\027\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\024\005 \f\r\016\017)20( )]TJ 0.191 Tw T* (\031\b\031\007\001\036\027\017\016 \235\031\027\022\006\017\017 \007\036\ \030\032\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\026 \032\017\027\017,)20( )]TJ 0.266 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC [(\r \017\f\f\035\036\007\024\r\026\027\017\017 Ander)-10(sen)]TJ /Span<>> BDC ( )Tj EMC (\221. \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \027\026\035\017\004\017\036)20( )]TJ -0.025 Tw T* [(\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 \002\t\035\024 \027\036\026\r\017\f\017\n\t\n \002\024\035\ \036\036)20( )]TJ 0.093 Tw T* (\027\017\022\024\020\024 \022\026\004\036\f\021\r\026 \032\017\027\017\ . \233\021\017 \030\026\035\017\004\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.154 Tw T* [(\027\t\b )0.6(\030\036\031\035\034\021\026\021\026\b )0.5(\n\024\020\031\021 )0.5(\002\t\021\034 )0.5(\024\002\031\f\035\024\r\035\036\027\t )0.5(\030\026\035\017\004)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.196 Tw T* (\027\t\n\017 \023\030\017\004\017\027\026\n\017, \r\024\n\024\032\027\024\ \026)Tj /Span<>> BDC ( )Tj EMC [(\f\004\036\021 \024\020\030\026\027\017\004\036\027\017\005)20( )]TJ -0.02 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005.)Tj 0 Tc 0.276 Tw T* [(\200\024-\023\036\030\r\t\b, \024\006\036\027\022\026 \017\f\b\024\007\024\ \r )0.5(\023\030\024\r\024\007\017\035\026\f\034 \017\f\022\035\033\004\017)]TJ 0 Tw (-)Tj 0.14 Tw T* (\021\036\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \024\023\030\024\f\027\017\ \022\024\r \(SF-36, \001\022\026\035\026 )Tj 0.069 Tw T* (\200\036\022\f\027\036\030\026\), \002\036 \023\030\017\n\036\027\036\027\ \017\016 \024\002\255\036\022\021\017\r\027\t\b \017\027\f\021\030\031\n\ \036\027)Tj 0 Tw (-)Tj 0.32 Tw T* [(\021\026\035\034\027\t\b )0.5(\n\036\021\024\007\024\r \(\027\026\023\030\017\n\036\030, \n\026\027\024\ \n\036\021\030\017\017, )0.5(\007\036\235\036\022\024)]TJ 0 Tw (-)Tj 0.23 Tw T* (\020\030\026\235\017\017, \220\027\007\024\f\022\024\023\017\017\), \004\ \021\024 \f\027\017\032\026\036\021 \021\024\004\027\024\f\021\034 \017\027\ \021\036\030)Tj 0 Tw (-)Tj 0.419 Tw T* (\023\030\036\021\026\006\017\017 \024\021\007\036\035\034\027\t\b \235\031\ \027\022\006\017\024\027\026\035\034\027\t\b \027\026\030\031\001\036\027\ \017\005. )Tj 0.699 Tw T* (\200\024-\r\021\024\030\t\b, \022\024\035\017\004\036\f\021\r\024 \023\026\ \006\017\036\027\021\024\r, \026\r\036\030\001\017\r\001\017\b )Tj 0.259 Tw T* (\023\024\r\021\024\030\027\t\005 \024\023\030\024\f, \024\020\030\026\027\ \017\004\036\027\024, \004\021\024 \n\024\020\035\024 \023\024\r\035\017\ \016\021\034 )Tj 0.216 Tw 23.244 64.543 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\007\024\f\021\024\r\036\030\027\024\f\021\034 \r\t\r\024\007\024\r. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )0.5(\n\t )]TJ -0.009 Tw T* (\023\030\024\007\024\035\032\026\036\n \030\026\002\024\021\031, \027\026\ \023\030\026\r\035\036\027\027\031\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\035\036\027\017\036 )Tj 0.214 Tw T* [(\235\031\027\022\006\017\024\027\026\035\034\027\t\b )0.6(\030\036\031\035\034\021\026\021\024\r )0.6(\027\036 )0.5(\021\024\035\034\022\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.425 0 Td (\007\026\027\027\t\n\017 )Tj 0.074 Tw -18.425 -1.218 Td (\024\023\030\024\f\027\017\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\027\t\b \001\022\026\035, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f \024\002\255\036\022\021\017\r\027\t)Tj 0 Tw (-)Tj 0.191 Tw T* (\n\017 \017\027\f\021\030\031\n\036\027\021\026\035\034\027\t\n\017 \023\ \024\022\026\026\021\036\035\016\n\017, \004\021\024 \023\024\r\024\035\ \017\021 )Tj -0.006 Tw T* (\002\024\035\036\036 \020\035\031\002\024\022\024 \023\024\027\016\021\034\ \n\036\b\026\027\017\n\t, \r\035\017\016\033\013\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024)Tj 0 Tw (-)Tj 0.048 Tw 0 -1.218 TD (\007\t \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\017\030\024\r\026\021\034 \023\024\f\035\036\007\ \031\033\013\036\036 \r\036\007\036\027\017\036 )Tj 0 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 603.0498 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.159 Tw 10 0 0 10 274.9606 578.6938 Tm (\222 \021\036\004\036\027\017\036\n \r\030\036\n\036\027\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (J-\024\002\030\026\027\t\n \221\221\217 )Tj 0.298 Tw T* [(\024\021\n\036\004\036\027\024 )0.5(\031\b\031\007\001\036\027\017\036 )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\t\b )0.6(\023\024\022\026\026\021\036\035\036\005 )]TJ 0.075 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\036\022\f\027\036\030\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\024\036 )Tj 0.034 Tw 0 -1.218 TD (\f\027\017\032\036\027\017\036 \022\026\004\036\f\021\r\026 \032\017\027\ \017, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0.225 Tw 0 -1.218 TD (\023\f\017\b\024\220\n\024\006\017\024\027\026\035\034\027\024\005 \f\024\ \f\021\026\r\035\016\033\013\036\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\021\026)Tj 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD (\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\005 \f\r\016\ \017 \n\036\032\007\031 \017\n\036\027\036\027\017\036\n \022\026)Tj 0 Tw (-)Tj 0.287 Tw 0 -1.218 TD (\004\036\f\021\r\026 \032\017\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\036\005 \007\036\030\032\026\027\017\016 \r\t\016\ \r\035\036\027\024 \027\036 )Tj 0.204 Tw 0 -1.218 TD (\002\t\035\024. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016, \023\024\022\026\026\021\036\035\017\ \235\017\017\004\036\f\022\024\020\024 \022\024\n)Tj 0 Tw (-)Tj 0.348 Tw 0 -1.218 TD (\023\024\027\036\027\021\026 \022\026\004\036\f\021\r\026 \032\017\027\017\ \024\f\021\026\r\026\035\017\f\034 \024\021\027\024\f\017\021\036\035\034\ \027\024 )Tj 0 Tw T* (\f\021\026\002\017\035\034\027\t\n\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.336 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.4(\016)13.7(:)]TJ /T1_4 1 Tf -0.004 Tc 0.34 Tw [( \202)12.1(\020)-9.2(\f)5(\020\025\031)5.6(\021)]TJ /Span<>> BDC 19.858 0 Td ( )Tj EMC [(\221)14.5(.)25.3(\206)89.9(.)3.8(,)-4( )]TJ -0.028 Tc 0.028 Tw -19.858 -1.218 Td [(\003)-45.3(\f)-24.7(\027)-23.1(\213)-18.4(\022)-20.8(\025)]TJ /Span<>> BDC 3.18 0 Td ( )Tj EMC [(\220)-26.6(.)0.5(\211)-3.7(.)-20.1(,)-28( \205\r)-18.7(\213)-20.8(\n)-18.2(\031)-18.4(\021)-28( \217.)1.3(\002)]TJ /T1_1 1 Tf 0 Tc 0.762 Tw -3.18 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC 4.496 0 Td [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.4(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.004 Tc 0.766 Tw [( \202)12.2(\020)-9.2(\f)5(\020\025\031)5.6(\021)]TJ /Span<>> BDC 14.936 0 Td ( )Tj EMC [(\221)14.6(.)25.3(\206)89.9(.)3.8(,)-4( )]TJ 0 Tc 0 Tw -19.432 -1.218 Td [(\036)-7.6(\f)3.3(\203)5.5(\022)4.6(\026)4(\031)9.7(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\224)26.6(.)7.3(\003)-2.3(.)7.8(, \221)3.8(\f)9.1(\020)12.2(\b)3.7(\031\030)4.8(\020)1.8(\023)9.6(\025)7.7(\013)10.1(\235)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)]TJ /T1_1 1 Tf 0.018 Tc -0.08 Tw T* [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21.1(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0 Tc -0.062 Tw 11.287 0 Td [( \202)16.1(\020)-5.2(\f)9(\020)4.3(\025)3.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\221)18.5(.)29.3(\206)93.9(.)7.8(, \003)-17.3(\f)3.3(\027)4.9(\213)9.6(\022)7.3(\025)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)28.5(\211)24.4(.)7.8(, )]TJ -0.007 Tc 0.007 Tw -11.287 -1.218 Td [(\002)16.2(\b\025)2.5(\020)-5.2(\023)-3(\027)-4.7(\025)3.7(\n)2.8(\031)]TJ /Span<>> BDC 4.527 0 Td ( )Tj EMC [(\215)12.4(.\003)-9.3(.)0.8(,)-7( \215)3.6(\022\025)8.1(\b\020)-6.4(\016)-4.8(\031)2.6(\021)]TJ /Span<>> BDC 6.238 0 Td ( )Tj EMC [(\003)-9.3(.)69.5(\214)47.7(.)]TJ /T1_1 1 Tf 0.002 Tc 0.667 Tw -10.765 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0.669 Tw 8.362 0 Td [( \202)16.1(\020)-5.2(\f)9(\020)4.4(\025)3.7(\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\221)18.5(.)29.3(\206)93.9(.)7.8(, \003)-17.3(\f)3.3(\027)4.9(\213)9.6(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)28.5(\211)24.3(.)7.8(, )]TJ -0.029 Tc 0.029 Tw -8.362 -1.218 Td [(\205)-1.4(\r)-19.7(\213)-21.8(\n)-19.2(\031)-19.4(\021)]TJ /Span<>> BDC 2.926 0 Td ( )Tj EMC [(\217)-1.4(.\002.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -2.926 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf 0.797 Tw [( \205)27.6(\r)9.3(\213)7.2(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\217)27.7(.)29.3(\002)28.8(.)7.8(, \237)14.1(\020)-14.4(\200)-1.9(\026)6.9(\020)1.9(\023)4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)29.3(\216)122(.)7.9(, )]TJ -0.027 Tc 0.027 Tw T* [(\214)-23.1(\031)-24.6(\026)-23(\027)-24.6(\025)-16.3(\n)-17.2(\031)]TJ /Span<>> BDC 3.509 0 Td ( )Tj EMC [(\217)0.6(.)0.5(\224.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.509 -2.436 Td (AUTHORS CONTRUBUTION)Tj /T1_1 1 Tf 0.238 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t )0.5(a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 10.131 0 Td [(t)-16.7(h)-5.3(e )0.5(s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( )0.5(B)7(u)2.8(l)3.3(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC 7.427 0 Td [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.285 0 Td [(K)12.8(al)3.3(a)-0.8(n)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw -18.843 -1.218 Td [(D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(e)-18(s)9.6(h)6.2(i)8.4(n)-6(, O)-7.3(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)13(o)-0.6(v)]TJ /T1_1 1 Tf 0.714 Tw T* [(P)-8.9(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.2(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e m)1.9(a)-8.5(t)-15.1(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf [( B)7(u)2.8(l)3.3(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(al)3.4(a)-0.8(n)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(J)11.2(u)2.8(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(E)19.6(l)10.4(\243)8.9(m)-1.1(ov)10.7(a)-13.9(, A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)5.2(l)3.3(a)-0.8(g)-2.5(o)-7.8(d)1.9(a)-4.9(t)-6.2(n)6.1(y)]TJ /T1_1 1 Tf 0.819 Tw T* [(S)7(t)-27.7(a)-8.4(t)-37.4(i)2.7(s)-20(t)-37.3(i)5.2(c)-11.8(a)-1.5(l d)0.7(a)-8.4(t)-27.7(a p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g)9(:)]TJ /T1_4 1 Tf [( B)6.9(u)2.9(l)3.3(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(al)3.3(a)-0.8(n)2(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(e)-18(s)9.6(h)6.2(i)8.4(n)-6(, M)5.2(ar)-35.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(I)10(g)1.9(n)4.9(a)-4.9(t)2.8(e)-2.6(n)7.5(k)12.9(o)-3.7(, A)9.6(i)9.4(r)7.7(a)-4.8(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(n)3.8(ga)-3(s)4.9(ov)]TJ /T1_1 1 Tf 0.081 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.1(:)]TJ /T1_4 1 Tf [( B)7(u)2.8(l)3.3(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(al)3.3(a)-0.8(n)1.9(o)-0.6(v)33.6(, D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(e)-18(s)9.6(h)6.2(i)8.4(n)-6(, )]TJ 0 Tw T* [(O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)12.9(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0.528 Tw 3.238 0 Td [( O)-7.3(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)12.9(o)-0.6(v)33.6(, D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(a)1.7(k)5.4(h)5.2(m)4.3(a)-4.9(t)1.4(o)-0.6(v)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(O)-5.5(k)-17.5(s)7.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(. F)19.1(om)-1.1(e)-2.6(n)7.5(k)13(o)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\025\026\035\026\027\024\r \207.\217.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0001-4679-5756)Tj 0 -1.218 TD (\222\031\001\022\024\r \210.\230.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj 0 -1.218 TD (\202\035\036\001\017\027 \212.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8863-2229)Tj 0 -1.218 TD (\205\024\n\036\027\022\024 \210.\224.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9603-6988)Tj 0 -1.218 TD (\204\017\027\020\026\024\r \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj 0 -1.218 TD (\213\035\235\017\n\024\r\026 \224.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0007-3316-7041)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7645 56.0378 Tm (53)Tj ET endstream endobj 1373 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.472 Tw 10 0 0 10 70.8661 542.1599 Tm (\222 \021\036\004\036\027\017\036\n \r\030\036\n\036\027\017 \021\026\022\ \032\036 \024\021\n\036\004\036\027\024 \031\b\031\007\001\036\027\017\036\ )Tj 0.113 Tw 0 -1.218 TD (\235\031\027\022\006\017\017 \007\036\030\032\026\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\036\022\f\027\036\030\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n )Tj -0.029 Tw T* (\024\023\030\024\f\036 \n\036\007\017\026\027\026 \030\026\r\027\016\035\ \026\f\034 1 \(0; 2\) \002\026\035\035\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030)Tj 0 Tw (-)Tj 0.01 Tw T* (\027\024\n \024\023\030\024\f\036)Tj /Span<>> BDC ( )Tj EMC (\227 4 \(1; 10,5\) \002\026\035\035\026 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.01 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\). \233\021\024 \f\r\017)Tj 0 Tw (-)Tj 0.22 Tw T* (\007\036\021\036\035\034\f\021\r\031\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\n \027\026\030\026\f\021\026\027\017\017\ \f\017\n\023\021\024\n\024\r )Tj 0 Tw T* (\027\036\007\036\030\032\026\027\017\016 \f\024 \r\030\036\n\036\027\036\ \n.)Tj 0.409 Tw T* (\210\006\036\027\022\026 \r\026\017\n\024\f\r\016\017 \n\036\032\007\031\ \031\b\031\007\001\036\027\017\036\n \235\031\027\022\006\017\017 )Tj 0.022 Tw T* (\007\036\030\032\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036\n \022\026\004\036\f\021\r\026 \032\017\027\ \017 \023\030\024\017\r\036\007\036\027\026 )Tj 0.077 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \n\027\024\032\036\f\021\r\036\027\027\024\005\ \035\017\027\036\005\027\024\005 \030\036\020\030\036\f\f\017\017, \020\ \007\036 )Tj 0.113 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\036 \026\r\017\f\017\n\024\005 )0.5(\023\036\030\036\n\036\027\027\024\005 )0.5(\r\t\f\021\031\023\026\035\017 \021\036 )0.5(\007\024)]TJ 0 Tw (-)Tj 0.142 Tw T* (\n\036\027\t \025\240, \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n \r\t\016\r\035\036\027\024 \f\021\026\021\017\f\ \021\017\004\036\f\022\017 \027\026)Tj 0 Tw (-)Tj 0.139 Tw T* (\004\017\n\024\036 \f\027\017\032\036\027\017\036, \026)Tj /Span<>> BDC ( )Tj EMC (\r \022\026\004\036\f\021\r\036 \023\030\036\007\017\022\021\024\030\024\ \r \017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.09 Tw T* (\024\r\026\035\017\f\034 \024\006\036\027\022\026 \026\027\026\035\034\027\ \024\005 \017\027\022\024\027\021\017\027\036\027\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 )Tj 0 Tw T* (\200\036\022\f\027\036\030\026, \023\024\035 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.266 Tw T* (\202\027\026\035\017 \023\024\022\026\026\035, \004\021\024 \r\t\030\026\ \032\036\027\027\024\f\021\034 \017\027\022\024\027\021\036\027\036\027\006\ \017\017 )Tj 0.238 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\036\022\f\027\036\030\026 \027\036 \016\r\035\016\ \035\026\f\034 \027\036\026\r\017\f\017\n\t\n \f\021\026)Tj 0 Tw (-)Tj 0.186 Tw T* (\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n \023\030\036\ \007\017\022\021\024\030\024\n \f\027\017\032\036\027\017\016 \022\026\004\ \036)Tj 0 Tw (-)Tj 0.101 Tw T* (\f\021\r\026 \032\017\027\017 \027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\n\036\027\024\r. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, )Tj 0.171 Tw T* (\007\024\n\036\027\t, \032\017\027\036\027\027\026\016 \026\022\021\017\ \r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\020\030\026\035\034\027\t\005 \023\024)Tj 0 Tw (-)Tj 0.374 Tw T* (\022\026\026\021\036\035\034)Tj /Span<>> BDC ( )Tj EMC (\227 \023\f\017\b\017\004\036\f\022\017\005 \022\024\n\023\024\027\036\027\ \021 \007\024\030\024\r\034\016)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.133 Tw T* [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 )0.6(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\031\033 )0.5(\024\021\030\017)]TJ 0 Tw (-)Tj T* (\006\026\021\036\035\034\027\031\033 \f\r\016\034 \f)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\f\022\017\n \023\024\035\024\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 249.8879 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.05 Tw 10 0 0 10 70.8661 225.5319 Tm (\203\026\001\026 \030\026\002\024\021\026 \007\036\n\024\027\f\021\030\017\ \030\031\036\021, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\n \027\026)Tj 0 Tw (-)Tj 0.065 Tw T* [(\002\035\033\007\036\027\017\017 \023\024\f\035\036 \235\024\030\n\017\030\ \024\r\026\027\017\016 )0.5(J-\024\002\030\026\027\024\020\024 \021\026\024\r\024)]TJ 0 Tw (-)Tj 0.048 Tw T* [(\020\024 )0.5(\030\036\036\030\r\031\026\030\026 )0.5(\024\021\n\036\004\026\036\021\f\016 )0.6(\f\027\017\032\036\027\017\036 )0.6(\022\026\004\036\f\021\r\026 )0.5(\032\017\027\017, )]TJ 0.226 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n, \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\f\017\b\017\004\036\f\022\024\n\031 \022\024\n\023\024\027\036\027\021\ \031, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.181 Tw T* [(\024\021\n\036\004\026\036\021\f\016 )0.5(\031\b\031\007\001\036\027\017\036 )0.5(\235\031\027\022\006\017\017 \007\036\030\032\026\027\017\016. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\021\024 )0.5(\032\036 )]TJ 0.103 Tw T* (\r\030\036\n\016, \023\024\022\026\026\021\036\035\017 \235\017\017\004\ \036\f\022\024\020\024 \f\024\f\021\024\016\027\017\016, \f\024\006\017\026\ \035\034)Tj 0 Tw (-)Tj 0.395 Tw T* (\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\030\024\035\036\r\024\020\024 \235\017\017\004\036\f\022\024\020\024 \235\ \031\027\022\006\017\024\027\017\030\024\r\026\027\017\016 )Tj 0 Tw T* (\024\f\021\026\035\017\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\032\027\036\n \031\030\024\r\027\036.)Tj -0.01 Tw T* (\222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \027\026\004\017\n\024\005 \f\r\016\017 \n\036\032\007\031 \024\006\036\ \027\022\024\005 )Tj 0.027 Tw T* (\022\026\004\036\f\021\r\026 \032\017\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\034\033 \017\027\022\024\027\021\017\ \027\036\027\006\017\017 \027\036 )Tj -0.026 Tw T* (\024\002\027\026\030\031\032\036\027\024. \200 \021\024 \032\036 \r\030\036\ \n\016, \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \026\027\026\035\017\026 \r\t\016\r\035\036\027\024, )Tj 0.156 Tw T* (\004\021\024 \032\036\027\013\017\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\017\030\031\033\013\017\n \221\221\217 \ \023\024\022\026\t\r\026\033\021 )Tj 0.18 Tw T* [(\002\024\035\036\036 \027\017\022\017\036 \023\024\022\026\026\021\036\ \035\017 \023\f\017\b\017\004\036\f\022\024\020\024 )0.5(\022\024\n\023\024\027\036\027\021\026 )]TJ 0.137 Tw 23.244 46.276 Td (\022\026\004\036\f\021\r\026 \032\017\027\017. \233\021\017 \030\036\031\ \035\034\021\026\021\t \f\024\024\021\r\036\021\f\021\r\031\033\021 \007\ \026\027)Tj 0 Tw (-)Tj 0.284 Tw T* [(\027\t\n \017\f\f\035\036\007\024\r\026\027\017\005 \202\004\022\026\f\024\ \r\026 )0.5(\222.\230. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2020\), )Tj 0.195 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \202\n\017\030\007\032\026\027\024\r\024\005 \200.\203\ . \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2008\), \r)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.191 Tw T* (\021\024\030\t\b \032\036\027\f\022\017\005 \023\024\035 \021\026\022\032\ \036 \002\t\035 \026\f\f\024\006\017\017\030\024\r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024)Tj 0 Tw (-)Tj 0.243 Tw T* (\035\036\036 \027\017\022\017\n\017 \002\026\035\035\034\027\t\n\017 \027\ \026\004\036\027\017\016\n\017, \023\024\035\031\004\036\027\027\t\n\017\ )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\017 SF-36 [9,10].)Tj 0.01 Tc 0.063 Tw T* (\221\026\022\032\036 \r\026\032\027\024 \031\023\024\n\016\027\031\021\034\ , \004\021\024 \f\030\036\007\017 \024\023\030\024\001\036\027\027\t\b \023\ \026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.026 Tw T* [(\006\017\036\027\021\024\r )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 4.316 0 Td (2)Tj /Span<>> BDC ( )Tj EMC 0.726 0 Td [(\(3,8%\) )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.661 0 Td [(\023\036\030\017\024\007 )0.5(\n\036\032\007\031 )0.5(\023\036\030\r\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.314 0 Td [(\r\021\024\030\t\n)10( )]TJ 0.177 Tw -19.017 -1.218 Td (\024\023\030\024\f\024\n \023\024\021\030\036\002\024\r\026\035\026\f\034\ \023\024\r\021\024\030\027\026\016 \024\023\036\030\026\006\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.03 Tw T* [(\027\017\r\036\007\036\027\017\036\n \030\036\036\030\r\031\026\030\026\ , \004\021\024 \027\026\004\017\021\036\035\034\027\024 \031\b\031\007\001\ \017\035\024)10( )]TJ -0.057 Tw T* (\235\031\027\022\006\017\024\027\026\035\034\027\t\036 \030\036\031\035\ \034\021\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\022\026\026\021\036\035\017 \007\036\030\032\026\027\017\016)10( )]TJ -0.036 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \002\024\035\034\027\t\b. \025\030\024\n\036 \021\024\020\ \024, \031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(5,7%\) \023\026\006\017\036\027\021\024\r \030\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.149 Tw T* [(\036\030\r\031\026\030 )0.5(\002\t\035 )0.5(\031\007\026\035\201\027 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 9.906 0 Td [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.5(\023\024\f\021\024\016\027\027\024\005)10( )]TJ 0.192 Tw -9.906 -1.218 Td (\f\021\024\n\t, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\r\017\021\017\036\n \020\027\024\005\027\t\b \024\f\035\024\032\ \027\036\027\017\005.)10( )]TJ 0.046 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC 0.792 0 Td (1)Tj /Span<>> BDC ( )Tj EMC 0.798 0 Td [(\(1,9%\) )0.5(\002\024\035\034\027\024\020\024 )0.5(\023\024\r\021\024\030\027\024 )0.5(\002\t\035\026 )0.5(\r\t\r\036\007\036\027\026 )0.5(\023\030\024\022)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.286 Tw -1.591 -1.218 Td [(\f\017\n\026\035\034\027\026\016 \f\021\024\n\026, \004\021\024 \017\f\022\ \035\033\004\017\035\024 \036\020\024 \007\026\035\034\027\036\005\001\036\ \036)10( )]TJ -0.004 Tw T* (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\027\026\n\017\004\036\f\022\024\005 \024\006\036\027\022\036 \235\ \031\027\022\006\017\017 \007\036\030\032\026\027\017\016.)Tj 0 Tc 0.298 Tw T* (\233\021\017 \027\026\002\035\033\007\036\027\017\016 \f\024\020\035\026\ \f\031\033\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n\017 \030\016\007\026 )Tj 0.513 Tw T* (\023\030\036\007\t\007\031\013\017\b \017\f\f\035\036\007\024\r\026\027\017\ \005. \221\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.112 Tw T* [(F)20(a)-24(zio)]TJ /Span<>> BDC ( )Tj EMC (V.W. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2013 \020., \r\022\035\033\004\026\033\013\036\n 3707)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.304 Tw T* [(\006\017\036\027\021\026\b, )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\024, )0.6(\004\021\024, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 16.65 0 Td [(\f\030\036\007\027\036\n, )0.5(\004\036)]TJ 0 Tw (-)Tj 0.269 Tw -16.65 -1.218 Td (\030\036 30)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \023\024\f\035\036 \024\023\036\030\026\006\017\017\ \031)Tj /Span<>> BDC ( )Tj EMC (132)Tj /Span<>> BDC ( )Tj EMC (\(3,6%\) \023\026)Tj 0 Tw (-)Tj 1.02 Tw T* (\006\017\036\027\021\024\r \023\024\021\030\036\002\024\r\026\035\024\f\034\ \031\007\026\035\036\027\017\036 \030\036\036\030\r\031\026\030\026. )Tj -0.016 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \031)Tj /Span<>> BDC ( )Tj EMC (53)Tj /Span<>> BDC ( )Tj EMC (\(1,4%\) \002\t\035 \023\024\r\021\024\030\027\024 \f\235\024\030\n\017\030\ \024\r\026\027 \221\221\217, )Tj 0.228 Tw T* (46)Tj /Span<>> BDC ( )Tj EMC (\(1,2%\) \023\026\006\017\036\027\021\026\n \002\t\035\026 \r\t\r\036\007\ \036\027\026 \024\021\022\035\033\004\026\033\013\026\016 )Tj 0 Tw T* (\017\035\036\024\f\021\024\n\026)Tj /Span<>> BDC ( )Tj EMC ([3].)Tj 0.361 Tw T* (\210\f\024\002\t\005 \017\027\021\036\030\036\f \023\030\036\007\f\021\026\ \r\035\016\033\021 \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.738 Tw T* (\027\t\n \020\024\030\017\024\027\021\024\n \027\026\002\035\033\007\036\ \027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.082 Tw T* [(Hahnl)30(oser)]TJ /Span<>> BDC ( )Tj EMC 4.326 0 Td [(D. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\(2004 \020.\), )0.5(\r\022\035\033\004\017\r\001\036\n )0.5(409 )0.5(\023\026)]TJ 0 Tw (-)Tj -0.01 Tw -4.326 -1.218 Td (\006\017\036\027\021\024\r, \024\023\036\030\017\030\024\r\026\027\027\t\ \b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \016\r\036\027\027\024\020\024 \022\024\035\017\021\ \026 )Tj 0.1 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 \027\026\002\035\033\007\036\027\017\016 \ 15 \035\036\021. \207\t\035\024 \023\024\022\026\026\027\024, \004\021\024\ )Tj 0.073 Tw T* (\024\021\n\036\004\026\036\021\f\016 \027\026\004\017\021\036\035\034\027\ \024\036 \f\027\017\032\036\027\017\036 \235\031\027\022\006\017\017 \007\ \036\030\032\026)Tj 0 Tw (-)Tj 0.009 Tw T* (\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\221\221\217: \004\026\f\021\024\021\026 \007\027\036\r\027\024\020\024 \ \027\036\007\036\030\032\026\027\017\016 )Tj 0.015 Tw T* [(\031\r\036\035\017\004\017\035\026\f\034 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.114 0 Td [(1% )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 2.749 0 Td [(10%, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 2.902 0 Td (\027\024\004\027\024\020\024)Tj /Span<>> BDC ( )Tj EMC 3.609 0 Td [(\227 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 1.932 0 Td [(2% )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 2.749 0 Td (24%. )Tj 0.19 Tw -20.055 -1.218 Td (\210\007\027\026\022\024 \f\024\006\017\026\035\034\027\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\036\f\f\017\024\027\026\035\034\027\026\016 \026\007\026\ \023\021\026\006\017\016 )Tj 0.206 Tw T* (\023\026\006\017\036\027\021\024\r \024\f\021\026\r\026\035\026\f\034 \r\ \t\f\024\022\024\005, 91% \023\026\006\017\036\027\021\024\r \f\024)Tj 0 Tw (-)Tj 0.014 Tw T* (\b\030\026\027\017\035\017 \023\030\036\032\027\036\036 \n\036\f\021\024\ \030\026\002\024\021\t \023\024\f\035\036 \024\023\036\030\026\006\017\017\ , 83% )Tj 0.024 Tw T* (\023\026\006\017\036\027\021\024\r \024\021\n\036\021\017\035\017, \004\021\ \024 \024\023\036\030\026\006\017\016 \027\036 \024\022\026\026\035\026\ \027\026\004\017)Tj 0 Tw (-)Tj T* (\n\024\020\024 \r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \021\030\031\007\024\f\023\024\f\024\002\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC ([6].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \215\025\031\255\027\024\023\021\027\025\025\013\027 \f\022\025\027\235\ \025\013\027 \032\027\b\032\027\024\024\022\022 \033\031)Tj /Span<>> BDC ( )Tj EMC [(\030\031\026\027\025\020\026 GH, VT, MH,)0.5( MHS)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.318 0 Td [( M)1.2(u)-1.6(l)5.3(t)-29.1(i)1.4(p)-4.9(le li)3.9(n)-2.4(e)-7.5(a)-4.2(r r)-1.9(e)-7.7(g)-1.5(r)-2(e)-22(s)-10.5(s)-12.5(i)-1.4(o)-4(n)3.7(s a)-9.1(c)-8.2(r)-2(o)-1.1(s)-10.5(s t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(G)5.6(H)-8(, V)-34.1(T)34(, M)8(H)-8(, a)-5(n)-4.8(d M)8(H)13.9(S d)-5.3(o)-4(ma)-6.3(i)3.9(n)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 71.1161 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 212.8484 715.181 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 212.8484 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 388.5965 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 388.5965 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 433.9508 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 703.7118 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 71.1161 692.2505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 212.8484 703.7118 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 212.8484 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 703.7118 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 388.5965 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 433.9508 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 703.7118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 692.2505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 524.6594 692.2505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 71.1161 680.7892 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 212.5984 692.2505 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 692.2505 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 692.2505 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 680.7892 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 524.6594 680.7892 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 71.1161 669.5779 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 212.5984 680.7892 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 680.7892 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 680.7892 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 669.5779 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 524.6594 669.5779 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 669.3279 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 71.1161 657.8667 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 212.8484 669.3279 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 212.8484 658.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 669.3279 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 658.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 669.3279 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 388.5965 658.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.3279 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 433.9508 658.1167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 669.3279 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 657.8667 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 524.6594 657.8667 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 71.1161 646.4054 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 212.5984 657.8667 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 646.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 657.8667 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 646.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 657.8667 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 646.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 646.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 646.4054 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 524.6594 646.4054 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 71.1161 635.1862 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 212.5984 646.4054 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 635.1862 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 646.4054 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 635.1862 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 388.5965 646.4054 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 635.1862 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 635.1862 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 635.1862 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 524.6594 635.1862 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8661 634.9362 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 71.1161 623.4749 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 212.8484 634.9362 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 212.8484 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 634.9362 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 634.9362 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 388.5965 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 634.9362 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 433.9508 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 634.9362 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 623.4749 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 524.6594 623.4749 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 71.1161 612.0136 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 212.5984 623.4749 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 623.4749 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 623.4749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 612.0136 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 524.6594 612.0136 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 71.1161 600.8023 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 212.5984 612.0136 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 612.0136 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 612.0136 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 600.8023 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 524.6594 600.8023 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 600.5523 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 71.1161 589.0911 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 212.8484 600.5523 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 212.8484 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 600.5523 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 600.5523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 388.5965 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 600.5523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 433.9508 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 600.5523 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 589.0911 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 524.6594 589.0911 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 71.1161 577.6298 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 212.5984 589.0911 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 589.0911 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 388.5965 589.0911 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 577.6298 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 524.6594 577.6298 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 71.1161 566.4105 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 212.5984 577.6298 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 212.8484 566.4105 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 577.6298 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 297.8878 566.4105 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 388.5965 577.6298 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 388.5965 566.4105 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 566.4105 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 566.4105 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 524.6594 566.4105 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8661 566.1605 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 212.8484 566.1605 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 297.8878 566.1605 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 388.5965 566.1605 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 433.9508 566.1605 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 479.3051 566.1605 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 120.2545 706.5464 Tm (\031\002\214\r\b SF-36)Tj 14.527 0 Td (\200\006\r\240\t\220\003\002\006)Tj ET q 0 0 566.929 793.701 re W n 0.3 w 4 M q 1 0 0 1 324.1785 706.8505 cm 0 0 m 0.488 -0.328 0.792 -0.424 1.144 -0.424 c 2.072 -0.424 2.752 0.368 2.752 1.28 c 2.752 1.984 2.4 2.504 1.704 2.84 c 2.176 3.128 2.4 3.544 2.4 3.984 c 2.4 4.832 1.624 5.248 0.864 5.248 c 0.32 5.248 -0.288 5 -0.496 4.464 c -0.592 4.232 -0.64 3.888 -0.64 3.424 c -0.64 -0.568 l -0.64 -1.072 -0.712 -1.544 -0.816 -2.032 c -0.152 -2.032 l -0.048 -1.544 0 -1.08 0 -0.656 c h 0 3.792 m 0 4.376 0.168 4.992 0.872 4.992 c 1.344 4.992 1.712 4.624 1.712 3.96 c 1.712 3.64 1.624 3.296 1.44 2.936 c 1.176 3 0.984 3.032 0.864 3.032 c 0.64 3.032 0.544 2.944 0.544 2.848 c 0.544 2.728 0.656 2.624 0.976 2.624 c 1.104 2.624 1.256 2.656 1.44 2.712 c 1.832 2.232 2.016 1.824 2.016 1.2 c 2.016 0.264 1.616 -0.16 1.08 -0.16 c 0.704 -0.16 0.288 0.096 0 0.312 c h S Q Q BT /T1_0 1 Tf 8 0 0 8 322.8905 706.5464 Tm (\243)Tj /T1_3 1 Tf ( \(95% \031\034\))Tj /T1_4 1 Tf 10.788 0.001 Td (p)Tj /T1_3 1 Tf 5.459 -0.001 Td (R\262)Tj 4.112 0 Td (\022 \214\002\240\r\f\t)Tj /T1_0 1 Tf -51.477 -1.433 Td (\210\002\013\036\036 \f\024\f\021\024\016\027\017\036 \007\024\030\024\r\ \034\016 \(GH\))Tj 19.295 0 Td (\231\022\026\035\026 \200\036\022\f\027\036\030\026)Tj 10.581 0 Td (\2440,56)Tj /Span<>> BDC ( )Tj EMC (\(\2441,64; 0,52\))Tj 11.197 0 Td (0,301)Tj 5.919 0 Td (0,13)Tj 5.919 0 Td (0,3)Tj -31.862 -1.433 Td (\200\024\030\026\f\021)Tj 8.826 0 Td (\2440,38)Tj /Span<>> BDC ( )Tj EMC (\(\2440,92; 0,16\))Tj 11.197 0 Td (0,160)Tj -21.113 -1.433 Td (\240\036\027\f\022\017\005 \023\024\035)Tj 9.416 0 Td (\24411,40)Tj /Span<>> BDC ( )Tj EMC (\(\24423,03; 0,24\))Tj 11.697 0 Td (0,055)Tj -41.073 -1.433 Td (\240\017\027\036\027\027\026\016 \026\022\021\017\r\027\024\f\021\034\(\ VT\))Tj 19.295 0 Td (\231\022\026\035\026 \200\036\022\f\027\036\030\026)Tj 10.581 0 Td (\2440,69)Tj /Span<>> BDC ( )Tj EMC (\(\2441,61; 0,23\))Tj 11.197 0 Td (0,138)Tj 5.919 0 Td (0,15)Tj 5.669 0 Td (0,19)Tj -31.612 -1.433 Td (\200\024\030\026\f\021)Tj 8.942 0 Td (\2440,19\(\2440,65; 0,26\))Tj 11.081 0 Td (0,398)Tj -21.113 -1.433 Td (\240\036\027\f\022\017\005 \023\024\035)Tj 8.666 0 Td (\24410,11)Tj /Span<>> BDC ( )Tj EMC (\(\24420,03; \2440,1977\))Tj /T1_3 1 Tf 12.28 -0.001 Td (0,046)Tj /T1_0 1 Tf -40.905 -1.433 Td (\215\f\017\b\017\004\036\f\022\024\036 \007\024\030\024\r\034\036 \(MH\)\ )Tj 19.295 0 Td (\231\022\026\035\026 \200\036\022\f\027\036\030\026)Tj 10.831 0 Td (0,14)Tj /Span<>> BDC ( )Tj EMC (\(\2440,78; 1,06\))Tj 10.947 0 Td (0,760)Tj 5.919 0 Td (0,05)Tj 5.669 0 Td (0,99)Tj -31.612 -1.433 Td (\200\024\030\026\f\021)Tj 8.826 0 Td (\2440,06)Tj /Span<>> BDC ( )Tj EMC (\(\2440,51; 0,40\))Tj 11.197 0 Td (0,807)Tj -21.113 -1.433 Td (\240\036\027\f\022\017\005 \023\024\035)Tj 9.916 0 Td (\2447,6)Tj /Span<>> BDC ( )Tj EMC (\(\24417,51; 2,23\))Tj 11.197 0 Td (0,126)Tj -41.073 -1.433 Td (\215\f\017\b\017\004\036\f\022\017\005 \022\024\n\023\024\027\036\027\021\ \007\024\030\024\r\034\016 \(MHS\))Tj 19.295 0 Td (\231\022\026\035\026 \200\036\022\f\027\036\030\026)Tj 10.581 0 Td (\2440,24)Tj /Span<>> BDC ( )Tj EMC (\(\2440,71; 0,22\))Tj 11.197 0 Td (0,294)Tj 5.919 0 Td (0,12)Tj 5.669 0 Td (0,38)Tj -31.612 -1.433 Td (\200\024\030\026\f\021)Tj 8.826 0 Td (\2440,08)Tj /Span<>> BDC ( )Tj EMC (\(\2440,31; 0,15\))Tj 11.197 0 Td (0,490)Tj -21.113 -1.433 Td (\240\036\027\f\022\017\005 \023\024\035)Tj 9.416 0 Td (\2445,10)Tj /Span<>> BDC ( )Tj EMC (\(\24410,11; \2440,09\))Tj /T1_3 1 Tf 11.53 -0.001 Td (0,046)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 28.0527 56.0378 Tm (52)Tj ET endstream endobj 1372 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\036\026)11(\202\017\020\004\t\t\217\004 \005\004\212)21(\002\020\200)21(\026)11(\017\026\217 \216\025\005\024\n\005\025\b\017\t\n\213 J-\025\255\005\017\ \212\t\025\013)10(\025 \005\004\212\004\005\b)11(\002\017\005\017 )]TJ 0 -1 TD [(\002\022\224\017\n\004\t\026)11.1(\025\b \224\025\016)-10(\020\004 \r)10(\025\020\224\005\025\r)-10(\026)-10(\237\r)-9.9(\026)10.9(\025\024\n\n \224\025\022\224\025\b\025\202\002 \213\212\b\004\t\t\025\013\ )10(\025 \r)10(\025\020\n\026)11(\017)]TJ 44.038 1 Td [(Late outcomes of\022J-pouch in patients af)-31(ter )]TJ 1.982 -1 Td [(pr)20(octocolectom)21(y for ulcer)21(ativ)12(e colitis)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.102 Tw 10 0 0 10 42.5197 408.2019 Tm (\200 \022\026\004\036\f\021\r\036 \026\r\017\f\017\n\t\b \023\036\030\036\ \n\036\027\027\t\b \030\026\f\f\n\026\021\030\017\r\026\035\017\f\034 )Tj 0.103 Tw 0 -1.218 TD (\024\021\007\036\035\034\027\t\036 \007\024\n\036\027\t \024\023\030\024\ \f\027\017\022\026 SF-36, \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n \024\021)Tj 0 Tw (-)Tj 0.14 Tw T* (\n\036\004\036\027\t \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\t\036 \017\n\036\027\036\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\r \022\026)Tj 0 Tw (-)Tj 0.268 Tw T* (\004\036\f\021\r\036 \023\030\036\007\017\022\021\024\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \002\026\035\035\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \200\036\022\f\027\036\030\026, )Tj 0.265 Tw T* (\023\024\035 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021 \023\026\006\017\036\027\021\024\r. \210\002\013\026\ \016 \027\026\004\017\n\024\f\021\034 \022\026\032)Tj 0 Tw (-)Tj 0.305 Tw T* [(\007\024\005 )0.5(\023\024\f\021\030\024\036\027\027\024\005 )0.6(\n\024\007\036\035\017 )0.5(\024\006\036\027\017\r\026\035\026\f\034 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.246 0 Td (\023\024\n\024\013\034\033 )Tj 0.153 Tw -18.246 -1.218 Td (F-\022\030\017\021\036\030\017\016; \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \027\026\004\017\n\024\f\021\017 )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.153 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05 \f\004\017\021\026)Tj 0 Tw (-)Tj 0.038 Tw T* (\035\024\f\034, \004\021\024 \b\024\021\016 \002\t \024\007\017\027 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\017\022\021\024\030\024\r \017\n\036\036\021 \f\021\026\ \021\017\f)Tj 0 Tw (-)Tj 0.26 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\031\033 \f\r\016\034 \f)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\005 \023\036\030\036\n\036\027\027\024\005, )Tj 0.123 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.874 0 Td [(\n\024\007\036\035\034 )0.5(\023\030\017\027\026\r\026\035\026\f\034 )0.5(\027\026\004\017\n\024\005. )0.5(\212\035\016 )0.5(\007\026\035\034\027\036\005\001\036\020\024 )]TJ 0.067 Tw -0.874 -1.218 Td (\023\024\017\f\022\026 \f\r\016\017 \022\024\027\022\030\036\021\027\024\ \020\024 \023\030\036\007\017\022\021\024\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\n\036\027\027\024\005 )Tj -0.056 Tw T* (\024\021\022\035\017\022\026 \023\030\017\n\036\027\016\035\017 t-\022\030\ \017\021\036\030\017\005, \017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.056 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05 \f\004\017\021\026\035\017, )Tj -0.053 Tw T* (\004\021\024 \036\f\021\034 \f\021\026\021\017\f\021\017\004\036\f\022\017\ \027\026\004\017\n\026\016 \f\r\016\034. \203\024\030\n\026\035\034\027\ \024\f\021\034 )Tj 0.125 Tw T* (\030\026\f\023\030\036\007\036\035\036\027\017\016 \026\r\017\f\017\n\t\ \b \023\036\030\036\n\036\027\027\t\b \023\030\024\r\036\030\016\035\026\ \f\034 )Tj -0.01 Tw T* [(\021\036\f\021\024\n \212\241\202\020\024\f\021\017\027\024\226\215\017\030\ \f\024\027\026, )0.5(\030\036\031\035\034\021\026\021\t )0.5(\022\024\021\024\030\024\020\024 \023\024)]TJ 0 Tw (-)Tj 0.09 Tw T* [(\r\024\035\017\035\017 )0.6(\f\004\017\021\026\021\034 )0.5(\030\026\f\023\030\036\007\036\035\036\027\017\036 )0.6(\002\035\017\022\017\n )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 18.296 0 Td (\027\024\030\n\026\035\034)Tj 0 Tw (-)Tj 0.032 Tw -18.296 -1.218 Td (\027\024\n\031. \202\027\026\035\017 \020\017\f\021\024\020\030\026\n\n\ \024\f\021\026\021\022\024\r \021\026\022\032\036 \023\024\007\021\r\036\ \030\007\017\035 )Tj 0.076 Tw T* [(\017\b )0.5(\023\030\017\002\035\017\032\036\027\017\036 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 7.989 0 Td [(\027\024\030\n\026\035\034\027\024\n\031 )0.6(\030\026\f\023\030\036\007\036\035\036\027\017\033, )0.5(\004\021\024 )]TJ 0 Tw -7.989 -1.218 Td (\024\002\024\f\027\024\r\t\r\026\035\024 \023\030\017\n\036\027\036\027\017\ \036 \035\017\027\036\005\027\024\005 \030\036\020\030\036\f\f\017\017.)Tj 0.126 Tw T* (\222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \r\024 \r\f\036\b \023\024\f\021\030\024\036\027\027\t\b \n\024\007\036\ \035\016\b )Tj 0.577 Tw T* (\022\024\220\235\235\017\006\017\036\027\021 \n\027\024\032\036\f\021\r\036\ \027\027\024\005 \007\036\021\036\030\n\017\027\026\006\017\017 \(R\262\)\ )Tj 0.113 Tw T* [(\024\f\021\026\r\026\035\f\016 )0.6(\027\017\022\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.661 0 Td [(\027\036 )0.5(\023\030\036\r\t\001\026\035 )0.6(0,15, )0.5(\004\021\024 )0.5(\031\022\026\t\r\026)]TJ 0 Tw (-)Tj 0.361 Tw -8.661 -1.218 Td (\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\027\031\033 \024\002\255\016\f\027\017\ \021\036\035\034\027\031\033 \f\023\024\f\024\002\027\024\f\021\034 )Tj 0.233 Tw T* (\023\030\036\007\017\022\021\024\030\024\r. \221\036\n \027\036 \n\036\027\ \036\036, \023\024\f\022\024\035\034\022\031 \006\036\035\034\033 \026\027\ \026)Tj 0 Tw (-)Tj 0.081 Tw T* (\035\017\026 \016\r\035\016\035\024\f\034 \027\036 \023\030\024\020\027\ \024\017\030\024\r\026\027\017\036 \017\f\b\024\007\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027)Tj 0 Tw (-)Tj 0.496 Tw T* (\022\026 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ \n\t\b \r\026\017\n\024\f\r\016\036\005 \n\036\032\007\031 )Tj 0.529 Tw T* (\023\024\022\026\026\021\036\035\016\n\017, \023\024\035\031\004\036\027\ \027\t\036 \030\036\031\035\034\021\026\021\t \f\024\b\030\026\027\016\033\ \021 )Tj 0.36 Tw T* (\027\026\031\004\027\031\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\031\033 \006\036\027\027\024\f\021\ \034. \212\026\027\027\t\036 \002\t\035\017 )Tj -0.039 Tw 23.244 32.881 Td [(\023\030\024\026\027\026\035\017\017\030\024\r\026\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \023\030\024\020\030\026\n\n\027\024\020\024 \ \024\002\036\f\023\036)Tj 0 Tw (-)Tj 0.144 Tw T* [(\004\036\027\017\016 G)20(r)-32.9(aphP\026dP)35(r)-37(is)26(m \r\036\030\f\017\016 8.4.3 \(Insight P)40(ar)-22(tner)-10(s, )]TJ 0 Tw T* (\222\231\202\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 347.3119 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.439 Tw 10 0 0 10 274.9606 322.9559 Tm (\222\030\036\007\017 \023\026\006\017\036\027\021\024\r, \r\022\035\033\004\ \201\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017, \n\031\032\004\017\027 )Tj 0.263 Tw T* (\002\t\035\024 30/49 \(61,2%\), \026)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027)Tj /Span<>> BDC ( )Tj EMC (\227 19/49 \(38,8%\). )Tj 0.029 Tw T* (\222\030\036\007\027\017\005 \r\024\030\026\f\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \023\036\030\r\024\020\024 \024\023\030\024\f\026 \f\ \024\f\021\026\r\017\035 )Tj 0.006 Tw T* (33,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,9 \035\036\021, \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 2 \024\023\030\024\f\026)Tj /Span<>> BDC ( )Tj EMC (\227 44,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,6 \035\036\021. )Tj 0.137 Tw T* (\222\030\036\007\027\017\005 \023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \026\022\030\t\021\017\016 \f\021\024\n\t \007\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030)Tj 0 Tw (-)Tj 0.249 Tw T* (\r\024\020\024 \026\027\022\036\021\017\030\024\r\026\027\017\016 \f\024\ \f\021\026\r\017\035 15,5)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (13,6 \n\036\f\016\006\036\r, )Tj 0.135 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \r\021\024\030\024\020\024 \024\023\030\024\f\026)Tj /Span<>> BDC ( )Tj EMC (\227 110,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (16,7 \n\036\f\016\006\036\r. )Tj 0.042 Tw T* [(\222\030\036\007\027\017\005 )0.5(\017\027\021\036\030\r\026\035 )0.5(\n\036\032\007\031 \023\036\030\r\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\r\021\024\030\027\t\n )0.5(\024\023\030\024)]TJ 0 Tw (-)Tj T* (\f\026\n\017 \f\024\f\021\026\r\017\035 78,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,6 \n\036\f\016\006\036\r.)Tj 0.018 Tw T* (\215\030\017 \024\006\036\027\022\036 \007\017\027\026\n\017\022\017 \022\ \026\004\036\f\021\r\026 \032\017\027\017 \n\036\032\007\031 \023\036\030\ \r\t\n )Tj 0.054 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\t\n \024\023\030\024\f\026\n\017 \f\021\026\021\ \017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\036 \f\027\017)Tj 0 Tw (-)Tj 0.218 Tw T* [(\032\036\027\017\036 )0.5(\024\021\n\036\004\026\035\024\f\034 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\017\n \007\024\n\036\027\026\n \001\022\026\035\t )0.5(SF-36, )]TJ -0.001 Tw T* (\022\026\022: \024\002\013\036\036 \f\024\f\021\024\016\027\017\036 \007\ \024\030\024\r\034\016 67 \(50; 82\) \023\030\024\021\017\r 57 )Tj 0.068 Tw T* (\(47; 75\) \002\026\035\035\024\r; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.068 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,028, \032\017\027\036\027\027\026\016 \026\022\021\017\r\027\024\f\021\ \034 67 )Tj -0.002 Tw T* (\(50; 82\) \023\030\024\021\017\r 57 \(47; 75\) \002\026\035\035\024\r; \ )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.002 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0008, \023\f\017\b\017)Tj 0 Tw (-)Tj 0.108 Tw T* (\004\036\f\022\024\036 \007\024\030\024\r\034\036 72 \(60; 86\) \023\030\ \024\021\017\r 64 \(52;74\) \002\026\035)Tj 0 Tw (-)Tj T* (\035\024\r; )Tj /T1_2 1 Tf 2.002 0 Td (p)Tj /T1_1 1 Tf 0.009 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \017\027\021\036\020\030\026\035\034\027\024\n\031 \023\024\022\ \026\026\021\036\035\033 \023\f\017\b\017)Tj 0 Tw (-)Tj 0.108 Tw -2.002 -1.218 Td (\004\036\f\022\017\005 \022\024\n\023\024\027\036\027\021 \007\024\030\024\ \r\034\016 51,1 \(40,5; 55,1\) \023\030\024\021\017\r )Tj 0.011 Tw T* (45,3 \(38,7; 51\) \002\026\035\035\024\r; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.011 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034)Tj 0 Tw (-)Tj 0.06 Tw T* [(\027\t\n )0.5(\007\024\n\036\027\026\n )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\t\b )0.6(\017\n\036\027\036\027\017\005 )0.5(\027\036 )]TJ 0 Tw T* (\r\t\016\r\035\036\027\024.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\027\026\031\b\032\020\203\022\007\027\024\n\022\027 \200\020\032\020\ \n\023\027\032\022\024\023\022\n\022 \033\020\006\022\027\025\023\031\021\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-10.3(e)-7(m)-5.2(o)-8.6(g)-1.5(r)3.3(a)-5.2(p)-1.1(h)1.7(i)-1.8(c c)-2.5(ha)-4.2(r)3.4(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.3(e)-7(n)-0.6(t)-32.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9271 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 269.5413 694.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 382.9271 694.1118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 663.4504 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 663.4504 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9271 663.4504 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 651.9892 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 42.7697 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 651.9892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9271 651.9892 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 640.5279 cm 0 0 m 227.022 0 l S Q q 1 0 0 1 269.5413 640.5279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 382.9271 640.5279 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 136.2118 701.7464 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 22.083 0.6 Td (1 \002\212\006\002\217)Tj 0.282 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (76)Tj 13.891 1.2 Td (2 \002\212\006\002\217)Tj 0.282 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (49)Tj /T1_1 1 Tf -47.864 -1.433 Td (\215\024\035)Tj 1.063 -1.2 Td (\204\031\032\f\022\024\005)Tj T* (\240\036\027\f\022\017\005)Tj 31.807 1.2 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(53,9%\))Tj T* (35)Tj /Span<>> BDC ( )Tj EMC (\(46,1%\))Tj 14.173 1.2 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(61,2%\))Tj T* (19)Tj /Span<>> BDC ( )Tj EMC (\(38,8%\))Tj -47.043 -1.433 Td (\222\030\036\007\027\017\005 \r\024\030\026\f\021, \020\024\007\t)Tj 32.911 0 Td (33,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,9)Tj 14.516 0 Td (44)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,6)Tj -47.426 -1.433 Td (\222\030\036\007\027\017\005 \023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \026\022\030\t\021\017\016 \f\021\024\n\t, \n\036\ \f.)Tj 32.911 0 Td (15,5)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (13,6)Tj 13.923 0 Td (110,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (16,7)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.056 Tw 9 0 0 9 42.5197 623.8086 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \205\032\020\021\025\022\023\027\f\017\025\013\235 )0.5(\020\025\020\f\022\016 \033\031\n\020\016\020\023\027\f\027\235 \n\020\007\ \027\024\023\021\020 )0.5(\255\022\016\025\022 \(SF-36\) \022)]TJ /Span<>> BDC ( )Tj EMC (\203\r\025\n\006\022\031\025\020\f\017\025\013\200 \032\027\016\r\f\017\023\ \020\023\031\021 \(\213\n\020\f\020 \211\027\n\024)Tj /Span<>> BDC (-)Tj EMC 0 Tw 0 -1.2 TD (\025\027\032\020\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( C)1.2(o)-4(m)-1(p)-6.3(a)-4.1(r)3.3(a)-9.2(t)-29.1(i)-2.9(v)2.3(e a)-5.1(na)-4.4(l)6.6(y)-5.3(s)-12.5(i)6.6(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(q)-2.9(ua)-4.5(li)-3.4(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(li)5.1(f)-13.4(e \()33.9(S)17(F)0.5(-)22.8(3)23.4(6)39.4(\) a)-5(n)-4.8(d f)-18.1(u)0.6(n)-2.9(c)-32.4(t)-29(i)-1.4(o)-4(na)-4.5(l o)-3.4(u)-4.8(t)-3.4(c)2.8(o)-3.9(m)-5.3(e)-22(s \()-1.8(W)10.5(e)-32.4(x)-7.2(n)-2.4(e)-6(r sc)3.2(a)-4.5(le)54.3(\))]TJ ET /GS2 gs q 1 0 0 1 42.5197 597.7066 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 567.2874 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 309.2264 597.7066 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 567.2874 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 380.0925 597.7066 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 567.2874 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 450.9586 597.7066 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 567.2874 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 567.2874 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 567.0374 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 555.8261 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 567.0374 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 555.8261 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 567.0374 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 555.8261 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 567.0374 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 555.8261 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 555.8261 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 555.5761 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 544.3648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 555.5761 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 544.3648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 555.5761 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 544.3648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 555.5761 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 544.3648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 544.3648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 544.1148 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 532.9036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 544.1148 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 532.9036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 544.1148 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 532.9036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 544.1148 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 532.9036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 532.9036 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 532.6536 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 521.4343 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 532.6536 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 521.4343 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 380.0925 532.6536 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 521.4343 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 532.6536 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 521.4343 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 521.4343 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 521.1843 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 509.9651 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 521.1843 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 509.9651 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 380.0925 521.1843 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 509.9651 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 521.1843 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 509.9651 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 509.9651 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 509.7151 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 42.7697 498.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 509.7151 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 498.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 509.7151 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 498.5038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 509.7151 cm 0 0 m 45.604 0 l S Q 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266.707 0 l S Q q 1 0 0 1 42.7697 441.1736 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 452.3928 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 309.2264 441.1736 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 380.0925 452.3928 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 441.1736 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 452.3928 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 441.1736 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 441.1736 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 440.9236 cm 0 0 m 266.707 0 l S Q q 1 0 0 1 309.2264 440.9236 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 380.0925 440.9236 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 450.9586 440.9236 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 156.0543 579.472 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 20.45 1.2 Td (\200\r\006\013\005 \002\212\006\002\217)Tj 0.179 -1.2 Td (\(2018\2322019\))Tj 1.558 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (76)Tj 7.296 2.4 Td (\026\003\002\006\002\005 \002\212\006\002\217 )Tj 1.394 -1.2 Td (\(2025\))Tj 0.168 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(\210\002\013\036\036 \f\024\f\021\024\016\027\017\036 \007\024\030\024\r\ \034\016 \(GH\))Tj 35.123 0 Td (67)Tj /Span<>> BDC ( )Tj EMC (\(50; 82\))Tj 8.858 0 Td (57)Tj /Span<>> BDC ( )Tj EMC (\(47; 75\))Tj /T1_4 1 Tf 8.262 -0.001 Td (0,028)Tj /T1_1 1 Tf -52.244 -1.433 Td (\240\017\027\036\027\027\026\016 \026\022\021\017\r\027\024\f\021\034 \(\ VT\))Tj 35.123 0 Td (70)Tj /Span<>> BDC ( )Tj EMC (\(50; 80\))Tj 8.516 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(45; 67,5\))Tj /T1_4 1 Tf 8.327 -0.001 Td (0,0008)Tj /T1_1 1 Tf -51.966 -1.433 Td (\222\024\006\017\026\035\034\027\024\036 \235\031\027\022\006\017\024\027\ \017\030\024\r\026\027\017\036 \(SF\))Tj 34.188 0 Td (87,5)Tj /Span<>> BDC ( )Tj EMC (\(68,8; 100\))Tj 8.858 0 Td (87,5)Tj /Span<>> BDC ( )Tj EMC (\(68,8; 100\))Tj 9.365 0 Td (0,874)Tj -52.411 -1.433 Td (\217\024\035\036\r\024\036 \235\031\027\022\006\017\024\027\017\030\024\r\ \026\027\017\036, \024\002\031\f\035\024\r\035\036\027\027\024\036 \220\n\ \024\006\017\024\027\026\035\034\027\t\n \f\024\f\021\024\016\027\017\036\ \n \(RE\))Tj 34.373 0 Td (100)Tj /Span<>> BDC ( )Tj EMC (\(100; 100\))Tj 8.858 0 Td (100)Tj /Span<>> BDC ( )Tj EMC (\(100; 100\))Tj 9.18 0 Td (0,419)Tj -52.411 -1.433 Td (\215\f\017\b\017\004\036\f\022\024\036 \007\024\030\024\r\034\036 \(MH\)\ )Tj 35.123 0 Td (72)Tj /Span<>> BDC ( )Tj EMC (\(60; 86\))Tj 8.858 0 Td (64)Tj /Span<>> BDC ( )Tj EMC (\(52; 74\))Tj /T1_4 1 Tf 8.262 -0.001 Td (0,013)Tj /T1_1 1 Tf -52.244 -1.433 Td (\205\017\017\004\036\f\022\017\005 \022\024\n\023\024\027\036\027\021 \ \007\024\030\024\r\034\016 \(PHS\))Tj 34.096 0 Td (55,4)Tj /Span<>> BDC ( )Tj EMC (\(44,4; 55,8\))Tj 8.858 0 Td (51,6)Tj /Span<>> BDC ( )Tj EMC (\(43,9; 56,2\))Tj 9.457 0 Td (0,976)Tj -52.411 -1.433 Td (\215\f\017\b\017\004\036\f\022\017\005 \022\024\n\023\024\027\036\027\021\ \007\024\030\024\r\034\016 \(MHS\))Tj 34.096 0 Td (51,1)Tj /Span<>> BDC ( )Tj EMC (\(40,5; 55,1\))Tj 9.201 0 Td (45,3)Tj /Span<>> BDC ( )Tj EMC (\(38,7; 51\))Tj /T1_4 1 Tf 8.947 -0.001 Td (0,013)Tj /T1_1 1 Tf -52.244 -1.433 Td (\231\022\026\035\026 \200\036\022\f\027\036\030\026 \(\002\026\035\035\t\ \))Tj 35.873 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(0; 2\))Tj 8.266 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(1; 10,5\))Tj /T1_4 1 Tf 7.432 -0.001 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 511.9395 56.0378 Tm (51)Tj ET endstream endobj 19 0 obj <> endobj 20 0 obj <> endobj 21 0 obj <> endobj 22 0 obj <> endobj 23 0 obj <> endobj 1445 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1446 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1447 0 obj 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(\021\036\004\036\027\017\036 \007\035\017\021\036\035\034\027\024\020\024\ \023\036\030\017)Tj 0 Tw (-)Tj T* (\024\007\026 \027\026\002\035\033\007\036\027\017\016.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 651.7618 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.314 Tw 10 0 0 10 70.8661 627.4058 Tm [(\200 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 )0.6(\r\022\035\033\004\036\027\024 )0.6(76 )0.5(\023\026\006\017\036\027\021\024\r, )0.5(\022\024\021\024\030\t\n )]TJ 0.069 Tw T* [(\002\t\035\026 \r\t\023\024\035\027\036\027\026 \022\024\035\023\030\024\ \022\021\220\022\021\024\n\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n )Tj 0.003 Tw T* (J-\024\002\030\026\027\024\020\024 \221\221\217 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \016\r\036\027\027\024\020\024 \022\024\035\017\021\ \026, \r \023\036\030\017)Tj 0 Tw (-)Tj 0.123 Tw T* (\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\016 2013 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\005 2018 \020\024\007\026. \232\021\024\002\t \024\006\036\027\017\ \021\034 )Tj 0.115 Tw T* (\022\026\004\036\f\021\r\024 \032\017\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 \007\036\030\032\026\027\017\016, \023\036\030\ \r\024\036 \026\027\022\036)Tj 0 Tw (-)Tj 0.091 Tw T* (\021\017\030\024\r\026\027\017\036 \002\t\035\024 \r\t\023\024\035\027\036\ \027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\027\024\016\002\030\016 2018 )Tj 0 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\021 2019 \020\020.)Tj 0.151 Tw T* (\222 \017\033\027\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\036\027\021\016\002\030\034 2025 \020\024\007\026 \023\026\006\017\036\ \027\021\026\n \002\t\035\017 \023\024)Tj 0 Tw (-)Tj 0.132 Tw T* (\r\021\024\030\027\024 \030\026\024\f\035\026\027\t \026\027\022\036\021\ \t \007\035\016 \024\006\036\027\022\017 \007\017\027\026\n\017\022\017 \ \017)Tj 0 Tw (-)Tj 0.07 Tw T* (\n\036\027\036\027\017\016 \017\031\004\026\036\n\t\b \023\024\022\026\ \026\021\036\035\036\005. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\n \026\027\022\036)Tj 0 Tw (-)Tj 0.03 Tw T* (\021\017\030\024\r\026\027\017\017 \023\030\017\027\016\035\017 \031\004\ \026\f\021\017\036 53/76 \(69,7%\) \023\026\006\017\036\027\021\026. )Tj 0.033 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC 0.759 0 Td [(\021\030\036\b )0.5(\023\026\006\017\036\027\021\024\r )0.6(\030\036\036\030\r\031\026\030 )0.5(\002\t\035 )0.6(\031\007\026\035\201\027 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 17.411 0 Td (\n\036\007\017\006\017\027)Tj 0 Tw (-)Tj 0.209 Tw -18.17 -1.218 Td (\f\022\017\n \023\024\022\026\026\027\017\016\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \020\027\024\005\027\024-\r\024\f)Tj 0 Tw (-)Tj 0.192 Tw T* (\023\026\035\017\021\036\035\034\027\t\b \024\f\035\024\032\027\036\027\017\ \005, \024\007\027\024\n\031 \023\026\006\017\036\027\021\031 \r\t\r\036\ \035\017 )Tj 0.013 Tw T* (\023\036\021\035\036\r\031\033 \017\035\036\024\f\021\024\n\031 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \024\002\027\026\030\031\032\036\027\017\016\ \026\021\036\022\026 )Tj 0.13 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \030\036\036\030\r\031\026\030\026. \233\021\ \017 \023\026\006\017\036\027\021\t \023\030\036\007\024\f\021\026\r\017\ \035\017 )Tj 0.133 Tw T* (\024\021\r\036\021\t \021\024\035\034\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022 SF-36, \023\024\f\022\024\035\034\022\031\ \027\036\035\034\016 )Tj 0.108 Tw T* (\002\t\035\024 \024\006\036\027\017\021\034 \235\031\027\022\006\017\033\ \007\036\030\032\026\027\017\016. \232\036\021\t\030\036 \023\026\006\017\ \036\027\021\026 )Tj 0.059 Tw T* (\024\021\022\026\026\035\017\f\034 \024\021 \031\004\026\f\021\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017, \007\036\r\016\021\027\026\007\ \006\026\021\034 )Tj 0.075 Tw T* (\004\036\035\024\r\036\022 \027\036 \031\007\026\035\024\f\034 \024\023\030\ \024\f\017\021\034 \017-\026 \024\021\f\031\021\f\021\r\017\016 \f\r\016\ \017 )Tj 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj -0.022 Tw T* (\222\024\030\024\022 \007\036\r\016\021\034 \(64,5%\) \023\026\006\017\036\ \027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\017\007\036\f\016\021\017 \001\036\f\021\017 )Tj 0.046 Tw T* (\023\030\036\007\024\f\021\026\r\017\035\017 \023\024\035\027\t\036 \024\ \021\r\036\021\t, \022\024\021\024\030\t\036 \002\t\035\017 \r\022\035\033\ \004\036)Tj 0 Tw (-)Tj 0.201 Tw T* (\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\ . \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ )Tj 0.143 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (2/49 \(3,8%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \n\036\032\007\031 \024\023\030\024\f\026\n\017\ )Tj 0.051 Tw 23.244 38.97 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \r\024\f\023\026\035\017\021\036\035\034\027\t\b \ \024\f\035\024\032\027\036\027\017\005 \002\t\035\026 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.285 Tw 0 -1.218 TD (\027\036\027\026 \030\036\030\036\036\022\006\017\016 \024\f\021\026\r\001\ \036\005\f\016 \004\026\f\021\017 \023\030\016\n\024\005 \022\017\001\022\ \017 )Tj 0.152 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC 0.821 0 Td [(\030\036\027\017\r\036\007\036\027\017\036\n )0.6(\030\036\036\030\r\031\026\030\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.778 0 Td [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.6(\027\024)]TJ 0 Tw (-)Tj -13.6 -1.218 Td (\r\024\020\024 \030\036\036\030\r\031\026\030\024-\026\027\026\035\034\027\ \024\020\024 \026\027\026\f\021\024\n\024\026.)Tj 0.335 Tw 0 -1.218 TD (\025\026\004\036\f\021\r\024 \032\017\027\017 \024\006\036\027\017\r\026\ \035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \r\026\035\017\007\017)Tj 0 Tw (-)Tj 0.278 Tw 0 -1.218 TD [(\030\024\r\026\027\027\024\020\024 \024\023\030\024\f\027\017\022\026 S)-16(hor)-22(t F)10(or)-16(m-36 Heal)56.1(t)-13(h Sur)-32(ve)-10.9(y )]TJ 0.35 Tw 0 -1.218 TD (\(SF-36\). \202\027\022\036\021\026 \f\024\f\021\024\016\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (36 \r\024\023\030\024\f\024\r, \024\021\r\036\021\t )Tj 0.274 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\036 \023\024\r\024\035\017\035\017 \024\006\036\027\ \017\021\034 \025\240 \023\024)Tj /Span<>> BDC ( )Tj EMC (8 \007\024\n\036\027\026\n )Tj 0.233 Tw T* (\(\001\022\026\035\026\n\): \235\017\017\004\036\f\022\024\036 \235\031\ \027\022\006\017\024\027\017\030\024\r\026\027\017\036, \030\024\035\036\ \r\024\036 )Tj 0.181 Tw T* (\235\031\027\022\006\017\024\027\017\030\024\r\026\027\017\036, \024\002\ \031\f\035\024\r\035\036\027\027\024\036 \235\017\017\004\036\f\022\017\ \n \f\024)Tj 0 Tw (-)Tj 0.033 Tw T* (\f\021\024\016\027\017\036\n; \021\036\035\036\f\027\026\016 \002\024\035\ \034, \024\002\013\036\036 \f\024\f\021\024\016\027\017\036 \007\024\030\ \024\r\034\016, )Tj 0.438 Tw T* (\032\017\027\036\027\027\026\016 \026\022\021\017\r\027\024\f\021\034, \ \f\024\006\017\026\035\034\027\024\036 \235\031\027\022\006\017\024\027\017\ \030\024)Tj 0 Tw (-)Tj 0.294 Tw T* (\r\026\027\017\036, \030\024\035\036\r\024\036 \235\031\027\022\006\017\024\ \027\017\030\024\r\026\027\017\036, \024\002\031\f\035\024\r\035\036\027\ \027\024\036 )Tj 0.162 Tw T* [(\220\n\024\006\017\024\027\026\035\034\027\t\n )0.6(\f\024\f\021\024\016\027\017\036\n, )0.6(\023\f\017\b\017\004\036\f\022\024\036 )0.5(\007\024\030\024\r\034\036. )]TJ 0.04 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.818 0 Td [(\026\r\017\f\017\n\024\f\021\017 )0.6(\024\021 )0.5(\r\024\023\030\024\f\026 )0.5(\026\027\022\036\021\026 )0.5(\023\030\036\007\035\026\020\026\035\026 )0.6(\024\021 )0.5(\007\r\031\b )]TJ 0.244 Tw -0.818 -1.218 Td (\007\024)Tj /Span<>> BDC ( )Tj EMC (6 \r\026\030\017\026\027\021\024\r \024\021\r\036\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\031\033\013\036\005 \020\030\026\007\026\ )Tj 0 Tw (-)Tj 0.128 Tw T* (\006\017\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\034\027\024\005 \001\022\026\035\036. \200\f\036 \001\022\ \026\035\t \020\030\026\007\031\017\030\024\r\026\035\017\f\034 )Tj 0.135 Tw T* (\024\021 0 \007\024)Tj /Span<>> BDC ( )Tj EMC (100 \002\026\035\035\024\r. \207\024\035\036\036 \r\t\f\024\022\017\005 \ \002\026\035\035 \031\022\026\t\r\026\036\021 )Tj 0.089 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\036 \023\024\022\026\026\021\036\035\017 \022\026\004\ \036\f\021\r\026 \032\017\027\017. \025\030\024\n\036 \021\024\020\024,\ )Tj 0.095 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\023\036\006\017\026\035\034\027\024\005 \235\ \024\030\n\031\035\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \030\036)Tj 0 Tw (-)Tj 0.341 Tw T* (\031\035\034\021\026\021\024\r \r\t\001\036\031\022\026\026\027\027\t\b\ \007\024\n\036\027\024\r \r\t\f\004\017\021\t\r\026\035\017\f\034 )Tj 0.169 Tw T* [(2 \017\027\021\036\020\030\026\035\034\027\t\b \023\024\022\026\026\021\ \036\035\016: )0.5(\235\017\017\004\036\f\022\017\005 \022\024\n\023\024\027\036\027\021 )]TJ 0.048 Tw T* (\007\024\030\024\r\034\016 \(PHS\) \(1\2264 \001\022\026\035\t\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\f\017\b\017\004\036\f\022\017\005 \036\020\024 \022\024\n)Tj 0 Tw (-)Tj T* (\023\024\027\036\027\021 \(MHS\) \(5\2268 \001\022\026\035\t\) [7].)Tj 0.006 Tw T* (\212\035\016 \024\006\036\027\022\017 \f\024\f\021\024\016\027\017\016 \235\ \031\027\022\006\017\017 \007\036\030\032\026\027\017\016 \022\017\001\036\ \004\027\024\020\024 )Tj 0.335 Tw T* (\f\024\007\036\030\032\017\n\024\020\024 \017\f\023\024\035\034\024\r\026\ \035\026\f\034 \025\035\017\r\035\036\027\007\f\022\026\016 \001\022\026\ \035\026 )Tj 0.216 Tw T* [(\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 W)22(e)-18(xner. \202\027\022\036\021\026 \r\022\035\033\004\026\035\026 )]TJ -0.02 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\024\r, \022\026\032\007\t\005 \r\024\023\030\024\f \ \024\006\036\027\017\r\026\035\f\016 \024\021 0 \007\024)Tj /Span<>> BDC ( )Tj EMC (4 \002\026\035)Tj 0 Tw (-)Tj -0.043 Tw T* (\035\024\r, \020\007\036 0 \002\026\035\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\035\027\024\036 \007\036\030\032\026\027\017\036 \r\f\036\b\ \022\024\n\023\024\027\036\027)Tj 0 Tw (-)Tj 0.063 Tw T* (\021\024\r \022\017\001\036\004\027\024\020\024 \f\024\007\036\030\032\017\ \n\024\020\024, 20 \002\026\035\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\007\036\030\032\026)Tj 0 Tw (-)Tj T* (\027\017\036 \r\f\036\b \022\024\n\023\024\027\036\027\021\024\r \022\017\ \001\036\004\027\024\020\024 \f\024\007\036\030\032\017\n\024\020\024 [8\ ].)Tj /T1_2 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_0 1 Tf -0.006 Tc 0.074 Tw 0 -1.218 TD (\210\023\017\f\026\021\036\035\034\027\t\036 \007\026\027\027\t\036 \023\ \030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC [(\r\017\007\036 \f\030\036\007\027\036\020\024)-6( )]TJ -0.06 Tw T* (\027\026\004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\022\r\026\007\030\026\021\017\004\027\t\n \024\021\ \022\035\024\027\036\027\017\036\n \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC [(SD\))-6( )]TJ 0.051 Tw T* [(\017\035\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 2.516 0 Td [(\r\017\007\036 )0.6(\n\036\007\017\026\027\t )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.792 0 Td [(\031\022\026\026\027\017\036\n )0.5(\027\017\032\027\036\020\024 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.109 0 Td [(\r\036\030\b\027\036\020\024)-6( )]TJ 0.105 Tw -18.417 -1.218 Td [(\022\r\026\030\021\017\035\036\005 \(Me \(Q1; Q3\)\) \r \026\r\017\f\017\ \n\024\f\021\017 \024\021 \b\026\030\026\022\021\036\030\026)-6( )]TJ 0.401 Tw T* (\030\026\f\023\030\036\007\036\035\036\027\017\016. \212\035\016 \f\030\026\ \r\027\036\027\017\016 \007\017\027\026\n\017\022\017 \017\n\036\027\036\ )Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.083 Tw T* [(\027\017\016 )0.5(\027\026\004\036\027\017\005 )0.5(\023\024\022\026\026\021\036\035\036\005 )0.5(\n\036\032\007\031 \007\r\031\n\016 )0.5(\r\030\036\n\036\027\027\t\n\017)-6( )]TJ 0.435 Tw T* [(\021\024\004\022\026\n\017 \023\030\017\n\036\027\016\035\f\016 \027\036\ \023\026\030\026\n\036\021\030\017\004\036\f\022\017\005 \022\030\017\021\ \036\030\017\005)-6( )]TJ 0.25 Tw T* [(\200\017\035\022\024\022\f\024\027\026. \222\024\020\035\026\f\027\024 \026\ \027\026\035\017\031 \030\036\031\035\034\021\026\021\024\r \023\036\030\ \r\024\020\024)-6( )]TJ 0.201 Tw T* (\026\027\022\036\021\017\030\024\r\026\027\017\016, \023\030\036\007\f\021\ \026\r\035\036\027\027\t\b \027\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (2020)Tj /Span<>> BDC ( )Tj EMC [(\020. [9],)-6( )]TJ 0.314 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n \023\024\023\031\035\016\006\017\024\027\027\024\020\ \024 \017\f\f\035\036\007\024\r\026\027\017\016)-6( )]TJ 0.048 Tw T* (\202\n\017\030\007\032\026\027\024\r\024\005 \200.\203. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [10], \002\t\035\026 \024\021\n\036\004\036\027\026 \f\ \021\026)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.307 Tw T* [(\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\026\016 \026\r\ \017\f\017\n\024\f\021\034 \024\006\036\027\022\017 \022\026\004\036\f\021\ \r\026)-6( )]TJ 0.188 Tw T* [(\032\017\027\017 )0.5(\024\021 )0.5(\r\024\030\026\f\021\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.238 0 Td [(\023\024\035\026 )0.5(\030\036\f\023\024\027\007\036\027\021\024\r: )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 9.56 0 Td [(\032\036\027\013\017\027)-6( )]TJ 0.105 Tw -18.798 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\036\036 \023\024\032\017\035\t\b \f\031\002\255\036\022\021\ \024\r \025\240 \002\t\035\024 \b\031\032\036. \215\024\220\021\024\n\031\ )-6( )]TJ 0.321 Tw T* [(\017\031\004\036\027\017\036 \r\026\017\n\024\f\r\016\017 \n\036\032\007\ \031 \f\024\f\021\024\016\027\017\036\n \235\031\027\022\006\017\017)-6( )]TJ 0.124 Tw T* (\007\036\030\032\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024\n \032\017\027\017 \002\t\035\024 \023\030\ \024\r\036\007\036\027\024 \n\036\021\024)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.327 Tw T* [(\007\024\n )0.5(\n\027\024\032\036\f\021\r\036\027\027\024\005 )0.6(\035\017\027\036\005\027\024\005 )0.6(\030\036\020\030\036\f\f\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 19.307 0 Td [(\031\004\036\021\024\n)-6( )]TJ 0.017 Tw -19.307 -1.218 Td (\220\021\017\b \235\026\022\021\024\030\024\r. \202\027\026\035\017 \r\t\ \023\024\035\027\016\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n)-6( )]TJ 0.207 Tw T* [(\024\002\013\036\005 \035\017\027\036\005\027\024\005 \n\024\007\036\035\ \017 \n\027\024\032\036\f\021\r\036\027\027\024\005 \030\036\020\030\036\ \f\f\017\017,)-6( )]TJ 0.099 Tw T* [(\004\021\024 )0.5(\023\024\r\024\035\017\035\024 )0.5(\024\007\027\024\r\030\036\n\036\027\027\024 )0.5(\031\004\017\021\t\r\026\021\034 )0.5(\r\035\017\016\027\017\036 )0.5(\022\026\022)-6( )]TJ 0 Tw T* (\022\024\035\017\004\036\f\021\r\036\027\027\t\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\021\036\020\024\030\017\026\035\034\027\t\b \023\036\030\036\n\036\ \027\027\t\b.)Tj ET q 70.866 100.97 221.102 218.683 re W n q /GS0 gs 221.1023475 0 0 218.7016779 70.8661504 100.9517173 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \205\200\027\026\020 \021\n\f\005\007\027\025\022\t \240\031\f\017\025\013\ \200 \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( Scheme of)Tj /Span<>> BDC ( )Tj EMC (inclusion of)Tj /Span<>> BDC ( )Tj EMC (patients in the)Tj /Span<>> BDC ( )Tj EMC (study)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 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nM[sn3Sy/TQP f˴m$1nd}YP(2166I G$~fYM#.R9 v"Pd뭓imII%i,g\ūtȖuh@ZdSi z3"%ٖT8ߦ#Z nuْHG~r,u:Q:[E$6nT+Ψ{ǵ<&D5d}K%%#_53fTbaŤ7^keNZ\8{،y֢e5h-zVz67[E*;!&嶙&ӄhIQ9B]jHXǑ=J V%65iVf״ݭe̔Q͑%IZ g"2QFIDV\RI Հʦj33鴬Iђ+3KLEFdx[CĻO;n50UQ Q:eFP0ú[jјƌhR١KV"a,i!K56Simd̜j#]r\(ܴ1&<3fpԍ.!&!""0J\T"8Rp̋U*GKW>Ce\v:VlD#,$UeC;9Tvt_j llyM)-%fn$шI2Q*Yd˱*ѓM5uRr3kiYa>dxH8b<ߙ`1nTKA!.i$:uý%i!=$M mdDT=Iw1OmLI&<)u(ڎ=Vcvs^xtԬfj2gBB*!l9vI2-VMpܭT#T.vqxlwZ ZjdEU&>XQ6̛.&Dd4}~avKX* $BT0 ) TMFm棶%$Kpjth^`,{]/C`D5d}O #ȉ̖MdF ԥRbzrFw\R%)XkՀȌC|&j[1Y4BDyʦQmvcCEerQ!jRD"y~·:,w]vR)aK4W)"$L}Giی'\*+Ⱥ2"BgB:! KD5d}c;mɊ!J:$$dJDwTR%eA$0f~Mq'0c͞7iĔ6RfɰGae&{ر1 n8ӓ&RxN4yYF@ASJE.*JJq+h2lj#2"#뇭0%C6`*7-$IE)CIÉTUYyZ9Hbarx/;=cbD5d}?g~S3ObЮq@qBiv|yKK ƖFeTӝ\yt Eme^[Y6bA6奼DHpʦUܭV' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' Pۯbp V' QsԕA+rRed22쌌LGɡ :$}T56 {b Mž؃So )56 {b Mž؃So )56 {b Mž؃So )56 {b Mž؃So )56 {b Mž؃So )56 {b Mž؃So )56 {b Mž؃So )56 {b Mž؃So )56 {b 1@ endstream endobj 1462 0 obj <>stream endstream endobj 1459 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\036\026)11(\202\017\020\004\t\t\217\004 \005\004\212)21(\002\020\200)21(\026)11(\017\026\217 \216\025\005\024\n\005\025\b\017\t\n\213 J-\025\255\005\017\ \212\t\025\013)10(\025 \005\004\212\004\005\b)11(\002\017\005\017 )]TJ 0 -1 TD [(\002\022\224\017\n\004\t\026)11.1(\025\b \224\025\016)-10(\020\004 \r)10(\025\020\224\005\025\r)-10(\026)-10(\237\r)-9.9(\026)10.9(\025\024\n\n \224\025\022\224\025\b\025\202\002 \213\212\b\004\t\t\025\013\ )10(\025 \r)10(\025\020\n\026)11(\017)]TJ 44.038 1 Td [(Late outcomes of\022J-pouch in patients af)-31(ter )]TJ 1.982 -1 Td [(pr)20(octocolectom)21(y for ulcer)21(ativ)12(e colitis)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 515.5841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 515.5841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 478.3763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 478.3763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 424.3071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.045 Tw 9 0 0 9 90.7087 730.4919 Tm [(AIM: to assess late functional outcomes and q)14(uality of life of restorativ)13(e p)46(roctocolectom)11(y with J-pouch in patients )]TJ 0.023 Tw 0 -1.111 TD [(with ulcerativ)13.1(e colitis.)]TJ 0.071 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: the retrospectiv)13(e study included 76 patients operated in 2013\2312018. Quality of life a\ nd )]TJ 0.101 Tw T* [(continence w)12(ere assessed using the SF-36 q)14(uestionnaire and the W)30(e)-15(xner incontinence scale. The f)-42.9(irst sur)-41.9(v)12.9(ey w)13(as )]TJ -0.011 Tw T* (done in 2018\2312019, and the second one)Tj /Span<>> BDC ( )Tj EMC [(\227 in 2025. Com)16(plete paired d)26(ata w)12(ere obtained from 49 \(64.5%\) patients. )]TJ 0.155 Tw 0 -1.111 TD [(P)18(aired com)16(par)-37(isons betw)12(een the tw)12(o sur)-42(v)13(eys w)12.1(ere per)-34(for)-13.9(med using the Wilco)14(xon signed-rank test. Associations )]TJ 0.023 Tw 0 -1.111 TD [(betw)12(een QoL and continence function w)12(ere analyzed using multiple linear reg)14(ression.)]TJ 0.004 Tw T* [(RESUL)30(T)-10(S: a signif)-43(icant decrease w)13(as detected in sev)13(eral SF-36 domains: g)12(eneral health \(GH\) 67 \(50; 82\) vs 57 \(47; )]TJ 0.057 Tw T* (75\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.028; vitality \(V)-37(T\) 67 \(50; 82\) vs 57 \(47; 75\), p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.0008; mental health \(MH\) 72 \(60; 86\) vs 64 \(52; )Tj 0.091 Tw T* (74\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.013; and in the mental com)16(ponent summar)-42.9(y \(MCS\) 51.1 \(40.5; 55.1\) vs 45.3 \(38.7; 51\), p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.013. )Tj 0.042 Tw T* [(N)17(o signif)-43(icant dif)-39.9(ferences w)12(ere found in the remaining domains. A mark)17.1(ed increase in incontinence sym)16(p)13(toms w)13(as )]TJ 0.045 Tw T* [(no)13(ted ov)13(er time: the median W)30(e)-15(xner score increased from 1 \(0; 2\) to 4 \(1; 10.5\), p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.0001. How)12(ev)12.9(er)61.1(, no signif)-43(i)]TJ 0 Tw (-)Tj 0.001 Tw T* [(cant association w)13(as found betw)12(een deter)-36.9(ioration of continence and q)14(uality of life according to reg)14(ression analysis. )]TJ 0.023 Tw T* [(F)11(emale g)11.9(ender w)13(as identif)-42.9(ied as an independent p)46(redictor of low)12(er QoL \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,046\).)Tj 0.14 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: ov)13(er time, patients with a J-pouch demonstrated a signif)-43(icant decline in continence function and )]TJ -0.003 Tw 0 -1.111 TD [(q)14(uality of life due to w)12(orse psychoemo)13(tional domains, while ph)12(ysical com)16(ponents remained relativ)13(ely stable. N)17(o)]TJ /Span<>> BDC ( )Tj EMC (sig)Tj 0 Tw (-)Tj 0.023 Tw T* [(nif)-43(icant cor)-16(relation w)13(as found betw)12(een QoL and continence im)16(pair)-13.9(ment.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 555.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( ulcerativ)13.1(e colitis, J-pouch, ileal pouch-anal anastomosis, q)14(uality of)]TJ /Span<>> BDC ( )Tj EMC [(life, functional outcomes, W)30(e)-14.9(xner score)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FUNDIN)23(G:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.202 0 Td [( this research receiv)13(ed no e)-15(xter)-14(nal funding)]TJ /T1_2 1 Tf 0.032 Tc -0.044 Tw -4.202 -2.617 Td [(F)3.4(O)-4.4(R)8.9( C)-17.3(I)-15.4(T)45.7(A)37.7(T)-24.3(I)-1.1(ON:)]TJ /T1_3 1 Tf 0.018 Tc -0.035 Tw 6.333 0 Td [( K)-30.2(a)-11.2(l)-37.6(a)-7.4(n)-11.6(o)-10.1(v)]TJ /Span<>> BDC ( )Tj EMC [(B)3.5(.R)-21.2(.)-23.2(, S)-11.9(u)-21.7(s)-8.6(h)-8.4(k)-3.4(o)-10.1(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.6(.)-9.6(I)-10.1(.)-23.3(, A)-11.4(l)-23.5(e)-22.6(s)-8.6(h)-13.7(i)-3(n)]TJ /Span<>> BDC ( )Tj EMC [(D)16.6(.)40.8(V)39.9(.)-23.3(, F)-20.8(o)-8.9(m)-16.4(e)-11.3(n)-8.6(k)-3.5(o O)11.6(.)51.9(Y)12.8(u)-8.8(.)-23.3(, M)-9.6(i)-2.9(n)-11.7(g)-7.9(a)-27.3(z)-11(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.7(.)0.6(F)68.4(.)-23.3(, E)-7.3(l)-22.1(f)-62.8(i)-3(m)-12.1(o)-10.2(v)-28.1(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)51.5(.)-23.7(A)-22.8(.)-23.2(, B)-10.2(l)-37.6(a)-10.6(g)-9.9(o)-20.2(d)-9.1(a)-18(t)-25.9(n)-14.7(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.7(.)-23.7(A)-22.8(.)-23.3(, I)-4.5(g)-8.6(n)-7.5(a)-18(t)-24.5(e)-11.3(n)-8.6(k)-3.4(o)]TJ /Span<>> BDC ( )Tj EMC [(M)-6.8(.)-23.7(A)-22.8(.)-23.3(,)18.1( )]TJ 0.011 Tc -6.338 -1.2 Td [(S)-9.5(h)-7.4(a)-10.4(k)-15.9(h)-5.3(m)-7.5(a)-17.3(t)-21.1(o)-9.4(v)]TJ /Span<>> BDC 5.104 0 Td ( )Tj EMC 0.208 0 Td [(D)17.2(.)15.9(G)-10.7(.)0.5( )0.5(L)-40.2(a)-17.3(t)-23.9(e)0.6( )0.5(o)-12.5(u)-15.4(t)-21.6(c)-5.6(o)-8.4(m)-15.7(e)-22(s)0.6( )0.5(o)-11.2(f)]TJ /Span<>> BDC 9.103 0 Td ( )Tj EMC 0.208 0 Td [(J)-17.8(-)-11.7(p)-21.4(o)-12.5(u)-5.6(c)-9.4(h)0.6( )0.5(i)-2.4(n)0.6( )0.5(p)-19.2(a)-17.3(t)-45.3(i)-10.2(e)-10.6(n)-16.5(t)-48(s)0.5( )0.6(a)-13.6(f)-65.3(t)-23.9(e)-11.2(r)0.5( )0.5(p)-12.8(r)-15(o)-15.9(c)-40.6(t)-21.1(o)-15.9(c)-5.7(o)-14.7(l)-22.9(e)-18.2(c)-40.7(t)-21(o)-8.4(m)-14.5(y)0.6( )0.5(f)-24.4(o)-10.9(r)0.5( )0.5(u)-7.5(l)-21(c)-8.9(e)-11.2(r)-30(a)-17.3(t)-45.4(i)-13.6(v)-17.8(e)0.5( )0.5(c)-5.6(o)-14.8(l)-15.8(i)-15(t)-45.3(i)-6.6(s)-14.6(.)0.6( )]TJ /T1_1 1 Tf 0.017 Tc -0.017 Tw 27.215 0 Td [(K)10.8(o)-3.3(l)0.5(o)-3.3(p)-0.7(rok)-22.3(t)-1(o)-3.2(lo)-6.4(g)-16.4(i)3.6(a)2.6(.)]TJ /T1_3 1 Tf 0 Tc -0.024 Tw 6.814 0 Td [( )0.5(2)-19(0)-14(2)-5.9(6)9.7(;2)-11.6(5)-9.3(\()27.6(1)34.2(\))4.3(:)-5.9(4)-45.2(8)-34.3(\226)-18.6(5)-33.5(4)-11.2(. )]TJ 0.023 Tc 0.024 Tw -48.652 -1.2 Td [(\()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.8(2)-1.4(5)-23.6(-)55.2(1)26.8(-)-30.2(4)-35(8)-25.7(-)-8(5)-23.3(4)]TJ /T1_2 1 Tf 0.01 Tc 0.103 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.5(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.108 Tw 10.746 0 Td [( )0.5(\202\020\f\020\025\031\021 )0.5(\221.\206., )0.6(\214\216\221\210 )0.5(\253\001\215\002\037 )0.5(\n\031\f\031\033\032\031\n\023\031\f\031\b\022\022 )0.5(\022\026\027\025\022 )0.5(\003.\001.)]TJ /Span<>> BDC ( )Tj EMC 24.577 0 Td [(\206\013\255\022\200\273 )0.5(\215\022\025\016\030\032\020\021\020 )0.5(\206\031\024\024\022\022, )0.5(\r\f.)]TJ /Span<>> BDC ( )Tj EMC 13.243 0 Td [(\205\020\f\t\026\020 )0.5(\003\030\022\f\t, )0.6(\030.)]TJ /Span<>> BDC ( )Tj EMC 7.418 0 Td (2, )Tj 0.023 Tw -55.989 -1.2 Td (\024\023\032.)Tj /Span<>> BDC ( )Tj EMC (28, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: kala\ nov.bulat@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.102 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.107 Tw 14.219 0 Td [( K)17(alanov B.R., Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology)42(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.224 -1.2 Td [(123423, R)22(ussia; e-mail: k)10.9(alanov)53.1(.bulat@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 11.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 11.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 359.4899 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.109 Tw 10 0 0 10 42.5197 335.1339 Tm (\025\024\035\023\030\024\022\021\220\022\021\024\n\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \021\026\024\r\024\020\024\ \021\024\027\022\024)Tj 0 Tw (-)Tj 0.045 Tw 0 -1.218 TD (\022\017\001\036\004\027\024\020\024 \030\036\036\030\r\031\026\030\026\ \(\221\221\217\) \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \030\026\f)Tj 0 Tw (-)Tj -0.041 Tw T* (\f\n\026\021\030\017\r\026\036\021\f\016 \022\026\022 \253\024\035\024\021\ \024\005 \f\021\026\027\007\026\030\021\273 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 )Tj 0.147 Tw T* [(\035\036\004\036\027\017\016 )0.6(\016\r\036\027\027\024\020\024 )0.5(\022\024\035\017\021\026 )0.6(\(\242\025\). )0.5(\204\036\021\024\007\017\022\026, )0.6(\r\023\036\030\r\t\036 )]TJ 0.017 Tw T* [(\024\023\017\f\026\027\027\026\016 P)40(ar)-23.9(k)-10(s A.G. \017)]TJ /Span<>> BDC ( )Tj EMC (Nicholls R.J. \r)Tj /Span<>> BDC ( )Tj EMC (1978 \020\024\007\031, \007\026\035\026 )Tj 0.376 Tw T* (\r\024\n\024\032\027\024\f\021\034 \017\002\036\032\026\021\034 \235\024\ \030\n\017\030\024\r\026\027\017\016 \023\024\f\021\024\016\027\027\024\005\ )Tj 0.042 Tw T* (\017\035\036\024\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\017\021\034 \026\027\026\035\034\027\031\033\ \007\036\235\036\022\026\006\017\033, \004\021\024 )Tj 0.201 Tw T* (\f\021\026\035\024 \r\026\032\027\t\n \001\026\020\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\033 \022\026\004\036\f\021\r\026 \032\017\ \027\017 )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r [1].)Tj 0.204 Tw T* (\200 \021\024 \032\036 \r\030\036\n\016, \027\036\f\n\024\021\030\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\004\036\r\017\007\027\t\036 \023\030\036\017\n\031\013\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\021\r\026, \007\026\027\027\026\016 \024\023\036\030\026\006\017\016 \ \f\024\023\030\016\032\036\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\024\n \027\036\024\023\021\017)Tj 0 Tw (-)Tj 0.314 Tw T* (\n\026\035\034\027\024\020\024 \235\031\027\022\006\017\024\027\026\035\034\ \027\024\020\024 \030\036\031\035\034\021\026\021\026. \215\024\f\035\036\ \007\027\017\005 )Tj 0.118 Tw T* (\n\024\032\036\021 \002\t\021\034 \024\002\031\f\035\024\r\035\036\027 \022\ \026\022 \030\026\r\017\021\017\036\n \f\023\036\006\017\235\017\004\036\ \f)Tj 0 Tw (-)Tj 0.467 Tw T* (\022\017\b \030\036\036\030\r\031\026\030-\026\f\f\024\006\017\017\030\024\ \r\026\027\027\t\b \024\f\035\024\032\027\036\027\017\005, \021\026\022 \ )Tj 0.014 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\016\n\017 \235\031\027\022\006\017\017 \ \007\036\030\032\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\017. \233\021\017 )Tj 0.145 Tw T* (\023\030\024\002\035\036\n\t \n\024\020\031\021 \024\022\026\t\r\026\021\ \034 \f\021\024\035\034 \027\026\004\017\n\024\036 \r\035\017\016\027\017\ \036 )Tj 0.03 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017, \004\021\024 \016\r\035\016\ \033\021\f\016 \023\030\017\004\017\027\024\005 \031\007\026\035\036\027\ \017\016 )Tj 0 Tw T* (\030\036\036\030\r\031\026\030\026 \031)Tj /Span<>> BDC ( )Tj EMC (5\22610% \002\024\035\034\027\t\b [2,3,4].)Tj 0.23 Tw T* (\212\024\035\020\024\f\030\024\004\027\024\036 \027\026\002\035\033\007\036\ \027\017\036 \007\036\n\024\027\f\021\030\017\030\031\036\021 \023\030\024\ \020\030\036\f)Tj 0 Tw (-)Tj 0.315 Tw T* (\f\017\030\031\033\013\036\036 \f\027\017\032\036\027\017\036 \235\031\027\ \022\006\017\024\027\026\035\034\027\t\b \023\024\022\026\026\021\036\035\ \036\005 )Tj 0.02 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\242\025, \023\036\030\036\027\036\f\001\017\b \025\215\233 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n )Tj 0.138 Tw T* (\221\221\217. \221\026\022, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n L)35(ovegr)-32(ove R.E. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2010\), )Tj 0.075 Tw 23.244 29.227 Td (\004\026\f\021\024\021\026 \030\026\r\017\021\017\016 \026\027\026\035\034\ \027\024\005 \017\027\022\024\027\021\017\027\036\027\006\017\017 \031\r\ \036\035\017\004\017)Tj 0 Tw (-)Tj T* (\r\026\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (32,2% \004\036\030\036 1 \020\024\007 \007\024)Tj /Span<>> BDC ( )Tj EMC (64,5% \004\036\030\036 20 \035\036\021)Tj /Span<>> BDC ( )Tj EMC ([5].)Tj 0.17 Tw T* (\222 \007\030\031\020\024\005 \f\021\024\030\024\027\t, \f\024\006\017\026\ \035\034\027\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\036\f\f\017\024\027\026\035\034\027\026\016 )Tj 0.079 Tw T* (\026\007\026\023\021\026\006\017\016 \023\026\006\017\036\027\021\024\r \ \024\f\021\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\r\024\035\034\027\024 \r\t\f\024\022\024\n )Tj 0.128 Tw T* [(\031\030\024\r\027\036. )0.5(\221\026\022, \023\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n )0.5(\035\017\021\036\030\026\021\031\030\t, )0.5(83% )0.5(\023\026\006\017\036\027\021\024\r )]TJ -0.006 Tw T* (\024\021\n\036\004\026\033\021, \004\021\024 \024\023\036\030\026\006\017\ \016 \027\036 \024\022\026\t\r\026\036\021 \027\026\004\017\n\024\020\024\ \r\035\017)Tj 0 Tw (-)Tj 0.242 Tw T* (\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \021\030\031\007\024\f\023\024\f\024\002\027\024\f\021\034, \026)Tj /Span<>> BDC ( )Tj EMC (98% \030\036\022\024\n\036\027\007\031\033\021 )Tj 0 Tw T* (\007\026\027\027\031\033 \024\023\036\030\026\006\017\033 \007\030\031\020\ \017\n [3,6].)Tj 0.538 Tw T* [(\233\021\017 )0.5(\023\030\024\021\017\r\024\030\036\004\017\r\t\036 )0.5(\030\036\031\035\034\021\026\021\t )0.5(\f\r\017\007\036\021\036\035\034\f\021\r\031\033\021 )]TJ 0.26 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC [(\021\024\n, \004\021\024 \r\035\017\016\027\017\036 \017\n\036\027\036\027\ \017\005 \235\031\027\022\006\017\017 )0.5(\030\036\036\030\r\031\026)]TJ 0 Tw (-)Tj 0.098 Tw T* (\030\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017 \024\f\021\026\036\021\f\016\ \027\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\026 \024\023\030\036\007\036)Tj 0 Tw (-)Tj 0.097 Tw T* (\035\036\027\027\t\n, \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \031\f\021\024\005\004\017\r\t\b \r\026\017\ \n\024\f\r\016\036\005 \n\036\032\007\031 )Tj 0.146 Tw T* (\220\021\017\n\017 \023\026\030\026\n\036\021\030\026\n\017 \023\024\022\ \026 \027\036 \023\024\007\021\r\036\030\032\007\036\027\024. \221\036\n\ \002\024)Tj 0 Tw (-)Tj 0.021 Tw T* (\035\036\036, \004\021\024 \002\024\035\034\001\017\027\f\021\r\024 \024\ \023\031\002\035\017\022\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\ \026\027\017\005 )Tj 0.073 Tw T* (\f\235\024\022\031\f\017\030\024\r\026\027\t, \023\030\036\017\n\031\013\ \036\f\021\r\036\027\027\024, \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \026\027\026\021\024)Tj 0 Tw (-)Tj 0.014 Tw T* (\n\024-\235\031\027\022\006\017\024\027\026\035\034\027\t\b \b\026\030\026\ \022\021\036\030\017\f\021\017\022, \004\026\f\021\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022)Tj 0 Tw (-)Tj 0.011 Tw T* (\021\036\030\026 \024\f\035\024\032\027\036\027\017\005, \021\024\020\007\ \026 \022\026\022 \r\024\023\030\024\f\t \022\026\004\036\f\021\r\026 \032\ \017\027\017, )Tj -0.028 Tw T* [(\024\f\024\002\036\027\027\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.862 0 Td [(\007\035\017\021\036\035\034\027\024\n )0.6(\027\026\002\035\033\007\036\027\017\017, )0.6(\024\f\r\036\013\036\027\t )0.5(\027\036)]TJ 0 Tw (-)Tj -5.862 -1.218 Td (\007\024\f\021\026\021\024\004\027\024 \023\024\035\027\024.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 115.9299 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.6 Tw 10 0 0 10 274.9606 91.5739 Tm (\230\031\004\036\027\017\036 \007\017\027\026\n\017\022\017 \f\024\f\021\ \024\016\027\017\016 \235\031\027\022\006\017\017 \007\036\030\032\026)Tj 0 Tw (-)Tj 0.483 Tw T* (\027\017\016 \022\017\001\036\004\027\024\020\024 \f\024\007\036\030\032\ \017\n\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\026 \022\026\004\036\f\021\r\026 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.927 56.0378 Tm (49)Tj ET endstream endobj 1456 0 obj [1463 0 R] endobj 1457 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 252.141 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 252.141 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 214.9332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 214.9332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-48-54)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 89.449 695.3259 Tm [(\036\026)11(\202\017\020\004\t\t\217\004 \005\004\212)21(\002\020\200)21(\026)11(\017\026\217 \216\025\005\024\n\005\025\b\017\t\n\213 J-\025\255\005\017\ \212\t\025\013)10(\025 )]TJ 0.773 -1.105 Td [(\005\004\212\004\005\b)11(\002\017\005\017 \002\022)-23.2(\224\017\n\004\t\026)11(\025\b \224\025\016)-10(\020\004 \r)10(\025\020\224\005\025\r)-10(\026)-10(\237\r)-9.9(\026)11(\025\024\n\n )]TJ 4.325 -1.105 Td [(\224\025\022)-23.3(\224\025\b\025\202\002 \213\212\b\004\t\t\025\013)10(\025 \r)10(\025\020\n\026)11(\017)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\037)41(\017\020\017\t\025\b\022)-23.3(\006.\033)124.1(.)]TJ 8.162 0 0 8.162 143.4315 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 148.0675 628.822 Tm [(, \001\002\204\r)10(\025\b\022)-23.2(\036.\030.)]TJ 0 Tw 8.162 0 0 8.162 232.6626 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 237.2986 628.822 Tm [(, \f)-21(\020\004\204\n\t\022)-23.2(\201.\021.)]TJ 0 Tw 8.162 0 0 8.162 319.1075 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 323.7434 628.822 Tm [(, \210\025\024\004\t\r)10.1(\025\022)-23.3(\036.\207.)]TJ 0 Tw 8.162 0 0 8.162 421.7505 633.484 Tm (1)Tj 14 0 0 14 426.3864 628.822 Tm (, )Tj -25.394 -1.143 Td [(\235\n\t\013)10(\017\212\025\b\022)-23.2(\f)-31(.\210.)]TJ 8.162 0 0 8.162 160.3148 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 164.9508 612.822 Tm [(, \240\020\216\n\024\025\b\017\022)-23.2(\207.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 266.5277 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 271.1636 612.822 Tm [(, \006\020\017\013)10(\025\202\017\026\t\217\221\022)-23.2(\f)-31(.\f)-30.9(.)]TJ 0 Tw 8.162 0 0 8.162 383.7857 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 388.4217 612.822 Tm [(, \030\013\t\017\026)11.1(\004\t\r)10(\025\022)-23.3(\235.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 489.5923 617.484 Tm (1)Tj 14 0 0 14 494.2282 612.822 Tm (, )Tj -30.24 -1.143 Td [(\222\017\220\024\017\026)11(\025\b\022)-23.2(\201.\031)72(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 157.1233 601.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 582.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 579.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \016)-9.9(\026\005)-31(.\022)-23.3(2)35(8, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 558.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 555.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(23)11(99)46(5, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf -0.025 Tw 9 0 0 9 119.0551 536.6488 Tm (\037\036\035\034: \031\006\027\025\022\023\017 \030\022\025\020\026\022\n\ \r \203\r\025\n\006\022\031\025\020\f\017\025\013\200 \032\027\016\r\f\017\ \023\020\023\031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\020 \255\022\016\025\022 \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\t\016\021\027\025\025\013\026 \n\031\f\022\023\031\026 )Tj 0.023 Tw 0 -1.111 TD (\033\031\024\f\027 \n\031\f\033\032\031\n\023\204\n\023\031\026\022\022 \ \024)Tj /Span<>> BDC ( )Tj EMC (\203\031\032\026\022\032\031\021\020\025\022\027\026 \206 \021)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\b\031\024\032\031\007\025\031\026 \033\027\032\022\031\030\027\ \025\020\240\f\005\030\027\025\022\t.)Tj 0.21 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027 \021\n\f\005\007\027\025\013\ 76 \033\020\006\022\027\025\023\031\021, \033\027\032\027\025\233\024\213\ \022\200 \031\033\027\032\020\006\022\005 \021)Tj /Span<>> BDC ( )Tj EMC (2013\2312018)Tj /Span<>> BDC ( )Tj EMC (\b\b. )Tj 0.063 Tw T* (\003\025\n\027\023\022\032\031\021\020\025\022\027 \033\032\031\021\031\030\ \022\f\031\024\017 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \031\033\032\031\024\ \025\022\n\020 SF-36 \022)Tj /Span<>> BDC ( )Tj EMC (\213\n\020\f\013 \211\027\n\024\025\027\032\020. \004\027\032\021\013\235\ \031\033\032\031\024 \033\032\031\200\031\030\022\f )Tj 0.042 Tw T* (\021)Tj /Span<>> BDC ( )Tj EMC (2018\2312019)Tj /Span<>> BDC ( )Tj EMC (\b\b., \021\023\031\032\031\235)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (2025 \b. \004\031\f\025\013\027 \030\020\025\025\013\027 \033\031\f\r\007\ \027\025\013 \r)Tj /Span<>> BDC ( )Tj EMC (49)Tj /Span<>> BDC ( )Tj EMC (\(64,5%\) \033\020\006\022\027\025\023\031\021. \205\032\020\021\025\027\ \025\022\027 \033\031\n\020\016\020)Tj 0 Tw (-)Tj 0.015 Tw 0 -1.111 TD (\023\027\f\027\235 \026\027\255\030\r \033\027\032\021\013\026 \022)Tj /Span<>> BDC ( )Tj EMC (\021\023\031\032\013\026 \031\033\032\031\024\031\026 \021\013\033\031\f\ \025\027\025\031 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\026\031\212\017\005 \n\032\022\023\027\032\022\t \211\022\f\n\031\ \n\024\031\025\020. \220\f\t \020\025\020\f\022\016\020 \021\016\020\022\ \026\031\024)Tj 0 Tw (-)Tj 0.033 Tw 0 -1.111 TD [(\021\t\016\022 )0.5(\026\027\255\030\r )0.5(\022\016\026\027\025\027\025\022\027\026 )0.6(\n\020\007\027\024\023\021\020 )0.6(\255\022\016\025\022 )0.5(\033\031)]TJ /Span<>> BDC ( )Tj EMC 18.34 0 Td [(\213\n\020\f\027 )0.5(SF-36 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 6.102 0 Td [(\203\r\025\n\006\022\022 )0.5(\030\027\032\255\020\025\022\t )0.5(\022\024\033\031\f\017\016\031\021\020\025\020 )0.5(\026\025\031\255\027\024\023\021\027\025\025\020\t )]TJ 0.023 Tw -24.442 -1.111 Td (\f\022\025\027\235\025\020\t \032\027\b\032\027\024\024\022\t.)Tj 0.18 Tw T* [(\206\036\207\210\035\034\003\201: )0.5(\016\020)]TJ /Span<>> BDC ( )Tj EMC [(\033\027\032\022\031\030 \025\020\240\f\005\030\027\025\022\t )0.5(\031\023\026\027\007\027\025\031 \024\023\020\023\022\024\023\022\007\027\ \024\n\022 )0.6(\016\025\020\007\022\026\031\027 \024\025\022\255\027\025\022\027 \240\020\ \f\f\017\025\031\235 \031\006\027\025\n\022 )0.5(\202\234 )]TJ -0.007 Tw T* (\033\031)Tj /Span<>> BDC ( )Tj EMC (\030\031\026\027\025\020\026 SF-36: \031\240\212\027\027 \024\031\024\023\ \031\t\025\022\027 \016\030\031\032\031\021\017\t \(GH\) 67 \(50; 82\) \033\ \032\031\023\022\021 57 \(47; 75\) \240\020\f\f\031\021; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,028, \255\022\016\025\027\025)Tj 0 Tw (-)Tj 0.029 Tw T* [(\025\020\t \020\n\023\022\021\025\031\024\023\017 \(VT\) )0.5(67 \(50; 82\) \033\032\031\023\022\021 )0.5(57 \(47; 75\) \240\020\f\f\031\021; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0008, \033\024\022\200\022\007\027\024\n\031\027 \016\030\031\032\031\021\ \017\027 \(MH\) 72 \(60; )Tj 0.004 Tw T* (86\) \033\032\031\023\022\021 64 \(52; 74\) \240\020\f\f\031\021; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031 \022\025\023\027\b\032\020\f\017\025\031\026\r \033\031\n\020\016\ \020\023\027\f\005 \033\024\022\200\022\007\027\024\n\022\235 \n\031\026\ \033\031\025\027\025\023 \016\030\031\032\031\021\017\t )Tj 0.095 Tw T* (\(MHS\) 51,1 \(40,5; 55,1\) \033\032\031\023\022\021 45,3 \(38,7; 51\) \240\ \020\f\f\031\021; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013. \004\031)Tj /Span<>> BDC ( )Tj EMC (\031\024\023\020\f\017\025\013\026 \030\031\026\027\025\020\026 \024\023\ \020\023\022\024\023\022\007\027\024\n\022 )Tj 0.205 Tw T* [(\016\025\020\007\022\026\013\200 )0.6(\022\016\026\027\025\027\025\022\235 )0.5(\025\027 )0.5(\021\013\t\021\f\027\025\031. )0.6(\020\n\255\027 )0.6(\031\023\026\027\007\027\025\031 )0.5(\021\013\032\020\255\027\025\025\031\027 )0.6(\025\020\032\020\024\023\020\025\022\027 )0.5(\024\022\026\033\023\031\026\031\021 )0.5(\025\027\030\027\032\255\020\025\022\t )0.5(\024\031 )]TJ 0.066 Tw 0 -1.111 TD (\021\032\027\026\027\025\027\026. \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\021\031\026 \031\033\032\031\024\027 \026\027\030\022\020\025\ \020 \240\020\f\f\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\213\n\020\f\027 \211\027\n\024\025\027\032\020 \032\020\021\025\t\f\020\ \024\017 1 \(0; 2\), \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\023\031\032\025\031\026 \031\033\032\031)Tj 0 Tw (-)Tj 0.091 Tw 0 -1.111 TD (\024\027)Tj /Span<>> BDC ( )Tj EMC (\227 4 \(1; 10,5\), p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001. \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\ \025\020\007\022\026\031\235 \021\016\020\022\026\031\024\021\t\016\022 \ \r\200\r\030\213\027\025\022\t \n\020\007\027\024\023\021\020 \255\022\016\ \025\022 )Tj 0.07 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\025\020\032\r\213\027\025\022\027\026 \203\r\025\n\006\022\022 \030\027\ \032\255\020\025\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \032\027\b\032\027\024\024\022\031\025\025\031\b\ \031 \020\025\020\f\022\016\020 \025\027 \021\013\t\021\f\027\025\031. \211\ )Tj /Span<>> BDC ( )Tj EMC (\023\031 \255\027 \021\032\027\026\t \255\027\025\024\n\022\235 )Tj 0.023 Tw T* (\033\031\f \031\n\020\016\020\f\024\t \025\027\016\020\021\022\024\022\026\ \013\026 \033\032\027\030\022\n\023\031\032\031\026 \240\031\f\027\027 \025\ \022\016\n\022\200 \033\031\n\020\016\020\023\027\f\027\235 \n\020\007\027\ \024\023\021\020 \255\022\016\025\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,046\).)Tj 0.154 Tw T* (\207\003\202\035\224\232\036\001\002\036: \024)Tj /Span<>> BDC ( )Tj EMC (\023\027\007\027\025\022\027\026 \021\032\027\026\027\025\022 \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (J-\031\240\032\020\016\025\013\026 \206 \031\023\026\027\007\027\025\031\ \r\200\r\030\213\027\025\022\027 \203\r\025\n\006\022\031\025\020\f\017\ \025\013\200 )Tj 0.074 Tw T* (\033\031\n\020\016\020\023\027\f\027\235 \033\031)Tj /Span<>> BDC ( )Tj EMC (\213\n\020\f\027 \211\027\n\024\025\027\032\020, \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\ \025\020\007\022\026\031\027 \024\025\022\255\027\025\022\027 \n\020\007\ \027\024\023\021\020 \255\022\016\025\022, \033\032\027\022\026\r\212\027\ )Tj 0 Tw (-)Tj 0.182 Tw T* (\024\023\021\027\025\025\031, \016\020)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\023 \033\024\022\200\031\204\026\031\006\022\031\025\020\f\017\ \025\031\235 \024\031\024\023\020\021\f\t\005\212\027\235. \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\ \025\020\007\022\026\031\235 \024\021\t\016\022 \026\027\255\030\r )Tj 0.006 Tw T* (\022\016\026\027\025\027\025\022\027\026 \n\020\007\027\024\023\021\020 \ \255\022\016\025\022 \022)Tj /Span<>> BDC ( )Tj EMC (\203\r\025\n\006\022\022 \030\027\032\255\020\025\022\t \021\013\t\021\f\ \027\025\031 \025\027 \240\013\f\031. \211)Tj /Span<>> BDC ( )Tj EMC (\023\031 \255\027 \021\032\027\026\t, \033\031\n\020\016\020\023\027\f\022\ \203\022\016\022\007\027\024\n\031)Tj 0 Tw (-)Tj 0.023 Tw T* (\b\031 \n\031\026\033\031\025\027\025\023\020 \n\020\007\027\024\023\021\ \020 \255\022\016\025\022 \031\024\023\020\021\020\f\022\024\017 \031\023\ \025\031\024\022\023\027\f\017\025\031 \024\023\020\240\022\f\017\025\013\ \026\022.)Tj /T1_2 1 Tf 0.01 Tc 0.036 Tw 8 0 0 8 70.9061 301.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.041 Tw 8.511 0 Td ( \t\016\021\027\025\025\013\235 \n\031\f\022\023, J-\031\240\032\020\016\ \025\013\235 \023\020\016\031\021\013\235 \023\031\025\n\031\n\022\213\027\ \007\025\013\235 \032\027\016\027\032\021\r\020\032, \n\020\007\027\024\023\ \021\031 \255\022\016\025\022, \203\r\025\n\006\022\031\025\020\f\017\025\ \013\027 \032\027\016\r\f\017\023\020\023\013, )Tj 0.023 Tw -8.516 -1.2 Td (\213\n\020\f\020 \211\027\n\024\025\027\032\020)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\024\023\025\026\025\030\023\021\027\032\026\025\023\033:)Tj /T1_0 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \022\024\023\031\007\025\022\n\022 \203\022\025\020\025\024\022\032\031\ \021\020\025\022\t \031\023\024\r\023\024\023\021\r\005\023)Tj /T1_2 1 Tf 0.033 Tc 0.085 Tw -8.655 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.09 Tw 9.257 0 Td ( \025\026\035\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\207.\217., \222\031\001\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\230., \202\035\036\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\224., \204\017\027\020\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\205., \213\035\235\017\n\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \207\035\026\020\024\007\026\021\027\t\005)Tj /Span<>> BDC ( )Tj EMC [(\202.\202.,)23( )]TJ 0.02 Tc -0.034 Tw -9.262 -1.2 Td (\230\020\027\026\021\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC 4.691 0 Td [(\204.\202., )0.5(\231\026\b\n\026\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.811 0 Td [(\212.\206. )0.5(\210\021\007\026\035\036\027\027\t\036 )0.5(\030\036\031\035\034\021\026\021\t )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 )0.6(J-\024\002\030\026\027\024\020\024 )0.5(\030\036\036\030\r\031\026\030\026 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 30.308 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\023\024\f\035\036 )0.6(\022\024\035\023\030\024\022\021\220\022\021\024\n\017\017)20( )]TJ 0.023 Tc 0.024 Tw -41.81 -1.2 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \016\r\036\027\027\024\020\024 \022\024\035\017\021\ \026. )Tj /T1_0 1 Tf -0.023 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (48\22654. https://doi.org/10.33878/2073-7556-2026-25-1-48-54)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 148.4677 188.7639 Tm [(Late outcomes of\022)-23.3(J-pouch in patients af)-31(ter )]TJ 1.026 -1.167 Td [(pr)20(octocolectom)21.1(y for ulcer)21(ativ)12.1(e colitis)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8662 143.26 Tm [(Bulat\022)-23.2(R.\022)-23.3(K)41(alanov)]TJ 8.162 0 0 8.162 163.1611 147.922 Tm (1)Tj 0.023 Tw 14 0 0 14 167.7971 143.26 Tm [(, Oleg\022)-23.2(I.\022)-23.3(Sushk)11(ov)]TJ 0 Tw 8.162 0 0 8.162 264.142 147.922 Tm (1)Tj 0.023 Tw 14 0 0 14 268.7779 143.26 Tm [(, Denis\022)-23.2(V)62(.\022)-23.3(Aleshin)]TJ 0 Tw 8.162 0 0 8.162 366.5639 147.922 Tm (1)Tj 0.023 Tw 14 0 0 14 371.1998 143.26 Tm [(, Ok)11(sana\022)-23.2(Y)40(u.\022)-23.3(F)15(omenk)11(o)]TJ 0 Tw 8.162 0 0 8.162 497.8407 147.922 Tm (1)Tj 14 0 0 14 502.4766 143.26 Tm (, )Tj -30.829 -1.143 Td [(A)20(yr)21(at\022)-23.3(F)94(.\022)-23.2(Minga)20(z)10(ov)]TJ 8.162 0 0 8.162 174.0254 131.922 Tm (1)Tj 0.023 Tw 14 0 0 14 178.6613 127.26 Tm [(, Y)40(ulia\022)-23.2(A)-31(.\022)-23.3(Elf)-21(imov)10(a)]TJ 0 Tw 8.162 0 0 8.162 282.5518 131.922 Tm (1)Tj 0.023 Tw 14 0 0 14 287.1877 127.26 Tm [(, Andr)31(ey\022)-23.2(A)-31(.\022)-23.3(Blagodatny)]TJ 0 Tw 8.162 0 0 8.162 421.1779 131.922 Tm (1)Tj 14 0 0 14 425.8138 127.26 Tm (, )Tj -25.353 -1.143 Td [(Maria\022)-23.2(A)-31(.\022)-23.3(Ignatenk)11.1(o)]TJ 8.162 0 0 8.162 181.3885 115.922 Tm (1)Tj 0.023 Tw 14 0 0 14 186.0245 111.26 Tm [(, Dmitriy\022)-23.2(G.\022)-23.3(Shakhmatov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 323.8784 115.922 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8662 96.9208 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1776 93.5908 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8662 84.9208 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1776 81.5908 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(P)10(ostgr)21(aduate Education \(Barrikadnay)21(ast., 2/1)69(, p.1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, Russia\))]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 545.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 536.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.2152 56.0378 Tm (48)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 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0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 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\n\024\024\002\t\n\026)11(\004\026)11(\017 \224\005\n\022)-23.3(\020\004\225\004\t\n\n )]TJ 1.344 -1.176 Td [(\024\004\016)-10(\026\t\025-\005\017\016\224\005\025\016)-9.9(\026\005\017\t\004\t\t\025\013)10(\025 \r)10.1(\025\020\025\005\004\r)-10(\026)11(\017\020\200\t\025\013)10(\025 \005\017\r\017 )]TJ -1.545 -1.176 Td [(\016\022)-23.3(\024\n\r\005\025\016\017\026)11.1(\004\020\020\n\026\t\025\221 \t\004\016)-9.9(\026)11(\017\255\n\020\200\t\025\016)-10(\026\200\206: \016\004\005\n\213 \r)-10(\020\n\t\n\225\004\016\r\n\220 )]TJ -0.517 -1.176 Td [(\016)-10(\020\002\225\017\004\b, \017\b\026)11(\025\005\217: \203\017\002)31(\212\025\020\r)10(\025\b\022)-23.2(\036.\007., \035\213\202\025\b\017\022)-23.3(\235.\f)-31(., \035\213\202\025\b\022)-23.3(\021.\037., )]TJ 0.545 -1.176 Td [(\210\004\202\025\005\n\t\025\b\022)-23.2(\201.\001., \037)62(\002\020\n\r)10(\025\b\017\022)-23.2(\240.\f)-31(., \240\005\217\013\n\t\022)-23.2(\201.\021., \035\004\202\n\t\022)-23.3(\240.\021., )]TJ 0 Tw 8.436 -1.235 Td [(\235\017\t\016\002\005\025\b\017\022)-23.2(\207.\001.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.309 Tw 10 0 0 10 42.5197 542.1599 Tm [(\230\n\n\031\027\024\021\036\030\026\023\017\016 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.131 0 Td [(\022\024\035\024\030\036\022\021\026\035\034\027\024\n )0.6(\030\026\022\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.66 0 Td (\027\026\035\017)Tj 0 Tw (-)Tj 0.471 Tw -19.791 -1.218 Td (\004\017\036\n \n\017\022\030\024\f\026\021\036\035\035\017\021\027\024\005\ \027\036\f\021\026\002\017\035\034\027\024\f\021\017 \023\024\022\026\026\ \035\026 )Tj 0.243 Tw 0 -1.218 TD [(\r\t\f\024\022\031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.896 0 Td [(\r\027\036\f\036\027\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007)Tj 0 Tw (-)Tj 0.335 Tw -11.896 -1.218 Td (\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\036\004\036\f\021\r\036\027\027\t\036 \022\035\017\027\017\004\036\ \f\022\017\036 \030\036\022\024\n\036\027\007\026\006\017\017. )Tj 0.286 Tw T* (\215\030\036\007\f\021\026\r\035\036\027\027\t\036 \026\r\021\024\030\026\ \n\017 \f\021\026\021\034\017 \021\030\017 \022\035\017\027\017\004\036\f\ \022\017\b )Tj 0.063 Tw T* (\027\026\002\035\033\007\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017\n\036\030, \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t, \031\f\023\036\001\027\024\ \020\024 )Tj 0.028 Tw T* (\027\026\027\026\004\036\027\017\016 \022\024\n\002\017\027\026\006\017\ \017 \017\023\017\035\017\n\031\n\026\002\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\024\035\031\n\026\002\026, )Tj 0.167 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\024\027\024\021\036\030\026\023\017\017 \023\036\ \n\002\030\024\035\017\031\n\026\002\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024)Tj 0 Tw (-)Tj 0.139 Tw T* (\035\016\b \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036\n \f\017\f\021\036\n\t \030\036\023\ \026\030\026\006\017\017 \027\036\f\023\026\030\036\027\027\t\b )Tj 0.047 Tw T* [(\027\031\022\035\036\024\021\017\007\024\r )0.6(\212\203\025 )0.5(\(MMR\), )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.333 0 Td (\007\030\031\020\024\005)Tj /Span<>> BDC ( )Tj EMC 3.109 0 Td [(\227 )0.5(\022\024\f\r\036\027\027\024\036 )0.5(\f\r\017)]TJ 0 Tw (-)Tj 0.107 Tw -14.442 -1.218 Td (\007\036\021\036\035\034\f\021\r\024 \024\021\027\024\f\017\021\036\035\034\ \027\024\005 \030\036\007\022\024\f\021\017 \021\026\022\024\020\024 \030\ \024\007\026 \027\024)Tj 0 Tw (-)Tj T* (\r\024\024\002\030\026\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036.)Tj 0.117 Tw T* (\203\036\002\036\t\027\021\036\030\036\f\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \f\035\031\004\026\016\b \017\n\n\031\027\024\021\036\030\026\ \023\017\016 )Tj 0.229 Tw T* (\002\t\035\026 \027\026\027\026\004\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\035\036\004\036\027\027\t\b \002\024\035\034\027\t\b, \017\ \f\b\024\007\027\024 )Tj 0.417 Tw T* (\023\024\035\031\004\017\r\001\017\b \027\036\024-\026\007\255\033\r\026\ \027\021\027\031\033 \b\017\n\017\024\021\036\030\026\023\017\033 \(\216\ \221\) )Tj 0.205 Tw T* (\017\035\017 \027\036\024\b\017\n\017\024\035\031\004\036\r\031\033 \021\ \036\030\026\023\017\033 \(\027\036\024-\216\214\221\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024)Tj 0 Tw (-)Tj 0.413 Tw T* (\007\031 \n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\ \027\027\t\b \024\023\031\b\024\035\036\005. \210\021\f\031\021\f\021\r\017\ \036 )Tj 0.135 Tw T* (\024\002\255\036\022\021\017\r\027\024\020\024 \024\021\r\036\021\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\216\221/\216\214\221 \023\024\f\035\031\032\017\035\024 \023\024\r\024\007\ \024\n )Tj 0.027 Tw T* [(\007\035\016 \017\f\f\035\036\007\024\r\026\027\017\016 MS)17(S \f\021\026\021\031\f\026 \024\023\031\b\024\035\017 \017)]TJ /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036)Tj 0 Tw (-)Tj 0.233 Tw T* (\020\024 \027\026\027\026\004\036\027\017\016 \021\036\030\026\023\017\017\ \017\027\020\017\002\017\021\024\030\026\n\017 \022\024\027\021\030\024\ \035\034\027\t\b )Tj 0.079 Tw T* (\017\n\n\031\027\027\t\b \021\024\004\036\022, \024\022\026\026\r\001\036\ \005\f\016 \r\036\f\034\n\026 \031\f\023\036\001\027\024\005. \233\021\024\ )Tj 0.049 Tw T* (\027\026\r\024\007\017\021, \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t, \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\f\035\034 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \017\n\n\031)Tj 0 Tw (-)Tj -0.019 Tw T* (\027\024\021\036\030\026\023\017\033 \n\024\032\027\024 \023\030\017\n\036\ \027\017\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\030\036\007\035\036\004\036\027\027\t\b \002\024\035\034)Tj 0 Tw (-)Tj 0.1 Tw T* [(\027\t\b, )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 2.858 0 Td [(\007\030\031\020\024\005, )0.5(\004\021\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 5.807 0 Td [(\002\024\035\034\027\t\b )0.6(33 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.007 0 Td [(34 )0.5(\035\036\021 )0.5(MS)17(S )0.6(\f\021\026\021\031\f )]TJ 0.18 Tw -14.673 -1.218 Td (\f\035\036\007\031\036\021 \024\023\030\036\007\036\035\016\021\034 \007\ \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \021\036\030\016\021\034 )Tj 0.032 Tw T* (\r\030\036\n\036\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\f\031\030\f\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\036 \f\031\002\024\023\021\017\n\026\035\ \034\027\024\020\024 )Tj 0 Tw T* (\035\036\004\036\027\017\016 \(\027\036\024-\216\221, \027\036\024-\216\214\ \221\).)Tj 1.015 Tw T* [(\204\t \024\002\030\026\013\026\036\n \r\027\017\n\026\027\017\036 \004\017\ \021\026\021\036\035\036\005 )0.5(\032\031\030\027\026\035\026 )]TJ 1.084 Tw 0 -1.218 TD (\253\025\024\035\024\023\030\024\022\021\024\035\024\020\017\016\273, \004\ \021\024 \024\002\027\026\030\031\032\036\027\017\036 \n\017\022\030\024\ )Tj 0 Tw (-)Tj 0.616 Tw 0 -1.218 TD (\f\026\021\036\035\035\017\021\027\024\005 \027\036\f\021\026\002\017\035\ \034\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017 \021\024\035\f\021\024\005 )Tj 0.13 Tw 23.244 35.316 Td (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \021\026\022\032\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\036 \007\035\016 \020\036\027\036\021\017\004\ \036\f\022\024\020\024 )Tj 0.06 Tw 0 -1.218 TD (\021\036\f\021\017\030\024\r\026\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021 \r\t\016\r\035\036\027\017\016 \027\026\f\035\ \036\007\f\021\r\036\027\027\024)Tj 0 Tw (-)Tj T* (\020\024 \025\217\217)Tj /Span<>> BDC ( )Tj EMC (\227 \f\017\027\007\030\024\n\026 \214\017\027\004\026 [1].)Tj -0.048 Tw T* (\211 \023\030\017\r\036\007\036\027\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \022\035\017\027\017\004\036\f\022\024\020\024\ \027\026\002\035\033\007\036\027\017\016 )Tj -0.054 Tw T* (\002\024\035\034\027\024\020\024 34 \035\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027\027\024\005 \023\024\021\036\030\036\ \005 \220\022\f\023\030\036\f\f\017\017 )Tj 0.08 Tw T* (\002\036\035\022\026 \030\036\023\026\030\026\006\017\017 \212\203\025 M\ SH6 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005)Tj 0 Tw (-)Tj 0.315 Tw T* [(\001\036\n )0.5(\n\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\036\ \f\022\024\n )0.6(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(\002\t\035 )]TJ 0.014 Tw T* (\024\002\027\026\030\031\032\036\027 \r\036\030\024\016\021\027\024 \023\ \026\021\024\020\036\027\027\t\005 \r\026\030\017\026\027\021 \027\031\022\ \035\036\024\021\017\007)Tj 0 Tw (-)Tj 0.185 Tw T* (\027\024\005 \023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\ \017 \020\036\027\026 \204SH6. \233\021\024 \023\024\r\024\035\017\035\024\ )Tj 0.177 Tw T* (\007\017\026\020\027\024\f\021\017\030\024\r\026\021\034 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\024\020\024 \f\017\027\007\030\024\n \214\017\027\004\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.229 Tw T* (\r\024\007\017\021\034 \036\n\031 \023\024\032\017\027\036\027\027\t\005\ \022\035\017\027\017\004\036\f\022\017\005 \n\024\027\017\021\024\030\017\ \027\020 )Tj 0.473 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \r\t\016\r\035\036\027\017\016 \r\024\n\024\032\027\ \t\b \035\024\022\026\004\036\f\021\r\036\027\027\t\b )Tj 0.051 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \030\026\035\017\004\ \027\t\b \024\030\020\026\027\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 \f\021\026)Tj 0 Tw (-)Tj 0.047 Tw T* (\007\017\017. \210\007\027\026\022\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 33 \035\036\021, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017 )Tj 0.178 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \007\017\026\020\027\024\ \f\021\017\030\024\r\026\027\026 \023\024\021\036\030\016 \220\022\f\023\ \030\036\f\f\017\017 )Tj 0.025 Tw T* (\002\036\035\022\024\r MLH1 \017)Tj /Span<>> BDC ( )Tj EMC (PMS2, \007\026\035\034\027\036\005\001\036\036 \n\024\035\036\022\031\035\ \016\030\027\024-\020\036\027\036)Tj 0 Tw (-)Tj T* (\021\017\004\036\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036\ \023\030\024\r\036\007\036\027\024 \027\036 \002\t\035\024.)Tj -0.002 Tc 0.295 Tw T* [(\200 \220\021\024\005 \f\r\016\017 \006\036\035\036\f\024\024\002\030\026\ \027\024 \f\036\022\r\036\027\017\030\024\r\026\027\017\036 \020\036\027\ \026)-2( )]TJ 0.057 Tw T* [(MLH1, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017 \024\021\030\017\006\026\021\036\035\034\027\024\n \030\036\ \031\035\034\021\026\021\036)Tj /Span<>> BDC ( )Tj EMC 16.426 0 Td [(\227 \r\t\023\024\035\027\017\021\034)-2( )]TJ 0.126 Tw -16.426 -1.218 Td (\023\024\017\f\022 \022\030\031\023\027\t\b \r\f\021\026\r\024\022/\007\036\ \035\036\006\017\005 \007\026\027\027\024\020\024 \020\036\027\026 \n\036\ \021\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.216 Tw T* [(\007\024\n MLP)25(A [2], \004\021\024 \023\024\r\024\035\017\021 \031\f\021\026\027\024\r\ \017\021\034 \031)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\027\024\020\024)-2( )]TJ -0.026 Tw T* (\f\017\027\007\030\024\n \214\017\027\004\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\024\007\017\021\034 \036\n\031 \023\024\032\017\027\036\027\ \027\t\005 \022\035\017\027\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.086 Tw T* (\004\036\f\022\017\005 \n\024\027\017\021\024\030\017\027\020.)Tj /Span<>> BDC ( )Tj EMC (\025\030\024\n\036 \021\024\020\024, \r)Tj /Span<>> BDC ( )Tj EMC [(\f\035\031\004\026\036 \r\t\016\r\035\036\027\017\016)-2( )]TJ 0.082 Tw T* (\023\026\021\024\020\036\027\027\024\020\024 \r\026\030\017\026\027\021\026\ \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\024\020\024 \017\n\036\036\021 \f\n\t\f\035 \030\036\ \022\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.201 Tw T* (\n\036\027\007\024\r\026\021\034 \212\203\025-\007\017\026\020\027\024\f\ \021\017\022\031 \r\f\036\b \036\020\024 \022\030\024\r\027\t\b \030\024\ \007)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.065 Tw T* (\f\021\r\036\027\027\017\022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b, \031)Tj /Span<>> BDC ( )Tj EMC [(\022\024\020\024 \021\026\022\032\036 \002\031\007\036\021 \024\002\027\026\ \030\031\032\036\027)-2( )]TJ 0.033 Tw T* [(\026\027\026\035\024\020\017\004\027\t\005 )0.5(\023\026\021\024\020\036\027\027\t\005 )0.5(\r\026\030\017\026\027\021, )0.5(\r\022\035\033\004\017\021\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.356 0 Td [(\020\030\031\023\023\031)-2( )]TJ 0.138 Tw -19.356 -1.218 Td (\030\017\f\022\026. \230\n\036\027\027\024 \021\026\022\024\005 \023\024\ \007\b\024\007 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\035\017\021 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.018 Tw 0 -1.218 TD [(\001\036\n \024\f\031\013\036\f\021\r\017\021\034 \023\036\030\f\024\027\ \017\235\017\006\017\030\024\r\026\027\027\024\036 \035\036\004\036\027\017\ \036 \022\026\022)-2( )]TJ 0 Tw 0 -1.218 TD (\f\026\n\024\020\024 \023\026\006\017\036\027\021\026, \021\026\022 \017\ )Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \022\030\024\r\027\t\b \030\024\007\f\021\r\036\027\027\017\ \022\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 152.4639 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc -0.053 Tw 8 0 0 8 42.5197 139.6292 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\205\036\007\016\027\017\027)Tj /Span<>> BDC ( )Tj EMC 3.787 0 Td [(\204.\224., )0.5(\206\035\026\007\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.906 0 Td [(\210.\202., )0.5(\206\024\030\007\036\036\r)]TJ /Span<>> BDC ( )Tj EMC 5.586 0 Td [(\222.\222., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.588 0 Td [(\f\024\026\r\021. )0.5(\215\030\026\022\021\017\004\036\f\022\017\036 )]TJ -0.032 Tw -19.163 -1.25 Td (\030\036\022\024\n\036\027\007\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027\027\024\n\031 \035\036\004\036\027\017\ \033 \030\026\022\026 \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017, )Tj 0.314 Tw 0 -1.25 TD (\030\036\022\021\024\f\017\020\n\024\017\007\027\024\020\024 \f\024\036\007\ \017\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017. )Tj /T1_1 1 Tf 0 Tw (\004\032\020\n\023\022\007\027\024\n\022\027 )Tj 0.014 Tc 0.5 Tw T* [(\032\027\n\031\026\027\025\030\020\006\022\022 R)27.4(USSC)21.4(O, \007\020\024\023\017 1. \207\f\031\n\020\007\027\024\023\021\027\025\025\ \013\027 \031\033\r\200\031\f\022.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.001 Tc 0.349 Tw -27.638 -1.25 Td [(2023;13\(3s2-1\):425\226482. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw (10.18027/2224-5057-2023-13-3s2-)Tj 0 Tc 0 Tw T* (1-425-482)Tj 0 0 0 1 k /GS1 gs 0.34 Tw [( / F)10(ed)17(y)22(anin)]TJ /Span<>> BDC ( )Tj EMC [(M.Y)35(u., Gl)-16(adkov)]TJ /Span<>> BDC ( )Tj EMC [(O.A., Gor)-23.9(deev)]TJ /Span<>> BDC ( )Tj EMC [(S.S., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj -0.02 Tw 29.055 6.25 Td [(P)35(r)-33(a)-17(c)-15.9(t)-32(ical r)-23.9(ecommend)42(a)15(t)-32(ions for dr)-22(ug tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC (cancer of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he col)30.1(on, )]TJ 0.006 Tw T* [(r)-24(ec)-15.9(t)17(osigmoid junc)-15.9(t)-32(ion )0.5(and r)-23.9(ec)-16(tum. )]TJ /T1_1 1 Tf 14.295 0 Td [(Malignant )0.5(tumours)]TJ /T1_3 1 Tf [(. )0.5(2023;13\(3s2-)]TJ 0.023 Tw -14.295 -1.25 Td (1\):425\226482. \(In Russ.\).)Tj 0.048 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)60(suk)-17(anov)]TJ /Span<>> BDC ( )Tj EMC 3.978 0 Td [(A.S., )0.6(Bar)-37(inov)]TJ /Span<>> BDC ( )Tj EMC 5.458 0 Td [(A.A., )0.6(S)-16(hubin)]TJ /Span<>> BDC ( )Tj EMC 5.26 0 Td [(V.P., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.18 0 Td [(al. )0.5(Ger)-15.9(ml)-31(ine )0.6(v)-15(ar)-37(iants )]TJ 0.065 Tw -19.172 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he MMR/EPC)20(AM genes in Russian p)32(a)15(t)-32(ients wi)-24(t)-13(h L)70(ynch syndr)-32(ome. )]TJ /T1_1 1 Tf 0.023 Tw T* [(R)22(ussian Open Medical Jour)-14(nal.)]TJ /T1_3 1 Tf ( 2024;13:e0308.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.9769 56.0378 Tm (47)Tj ET q 0 g /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC1 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c 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732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 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Gl)30(obal Cancer S)15(t)15(a)15(t)-31.9(ist)-32(ics 2020: )]TJ 0.003 Tc 0.349 Tw -1.296 -1.25 Td [(G)0.5(L)35.5(OB)0.5(O)0.5(C)20.5(A)51.4(N)0.5( E)0.5(s)0.5(t)-31.5(i)0.5(ma)15.5(t)0.5(e)0.5(s)0.5( of)]TJ /Span<>> BDC 10.088 0 Td ( )Tj EMC [(I)0.5(n)0.5(c)-23.5(id)0.5(e)0.5(n)0.5(ce)0.5( a)0.5(n)0.5(d M)-23.6(o)0.5(r)-21.5(t)15.5(a)0.5(l)-30.5(i)-23.5(t)-9.5(y W)20.5(o)0.5(r)-29.5(ld)-16.5(w)0.5(i)0.5(d)0.5(e f)0.5(o)0.5(r)3( )]TJ 0 Tc 0.232 Tw -10.088 -1.25 Td [(36 Cancer)-10(s in 185 Countr)-37(ies. )]TJ /T1_2 1 Tf [(C)-18(A: A)]TJ /Span<>> BDC ( )Tj EMC [(Cancer Jour)-13.9(nal for Clinicians. )]TJ /T1_1 1 Tf 0.023 Tw 0 -1.25 TD [(2021;71:209\226249. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3322/caa)-17(c.21660)]TJ 0 0 0 1 k /GS1 gs 0.252 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)70(ynch)]TJ /Span<>> BDC ( )Tj EMC [(HT, L)70(ynch)]TJ /Span<>> BDC ( )Tj EMC [(PM, L)-31.9(ansp)32(a, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he L)70(ynch syn)]TJ 0 Tw (-)Tj -0.005 Tw -1.296 -1.25 Td [(dr)-32(ome: Hist)17(or)-24(y, molecul)-16(ar gene)-11.9(t)-32(ics, scr)-23.9(eening, dif)-56(fer)-23.9(ent)-32(ial dia)-17(gnosis, )]TJ 0.173 Tw T* [(and medicolegal r)-33(amif)-27.9(ica)15(t)-32(ions. )]TJ /T1_2 1 Tf (Clinical Genetics.)Tj /T1_1 1 Tf ( 2009;76\(1\):1\22618. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1399-0004.2009.01230.x)Tj 0 0 0 1 k /GS1 gs 0.335 Tw -1.847 -1.25 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(inicr)-32(ope)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A, Sar)-32(gent)]TJ /Span<>> BDC ( )Tj EMC [(DJ. 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Mis)26(ma)15(tch r)-23.9(ep)32(air def)-28(ic)-24(iency )]TJ -0.015 Tw -1.296 -1.25 Td [(p)25(r)-24(edic)-15.9(ts r)-23.9(esponse of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(id tumor)-10(s t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(PD-1 bl)30(o)-16(ck)-17(ade. )]TJ /T1_2 1 Tf 0 Tw (Science)Tj /T1_1 1 Tf -0.015 Tw (. 2017 Jul )Tj 0.023 Tw T* [(28;357\(6349\):409\226413. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1126/sc)-24(ience.aan6733)]TJ 0 0 0 1 k /GS1 gs -0.053 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\205\036\007\016\027\017\027)Tj /Span<>> BDC ( )Tj EMC 3.787 0 Td [(\204.\224., )0.5(\206\035\026\007\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.906 0 Td [(\210.\202., )0.5(\206\024\030\007\036\036\r)]TJ /Span<>> BDC ( )Tj EMC 5.586 0 Td [(\222.\222., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.588 0 Td [(\f\024\026\r\021. )0.5(\215\030\026\022\021\017\004\036\f\022\017\036 )]TJ -0.032 Tw -19.163 -1.25 Td (\030\036\022\024\n\036\027\007\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\036\027\027\024\n\031 \035\036\004\036\027\017\ \033 \030\026\022\026 \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017, )Tj 0.02 Tw T* (\030\036\022\021\024\f\017\020\n\024\017\007\027\024\020\024 \f\024\036\007\ \017\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017. )Tj /T1_2 1 Tf 0 Tw (\207\f\031\n\020\007\027\024\023\021\027\025\025\013\027 )Tj T* (\031\033\r\200\031\f\022)Tj /T1_1 1 Tf 0.013 Tw [(. 2022;12\(3s2-1\):401\226454. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18027/2224-5057-2022-)Tj T* (12-3s2-401-454)Tj 0 0 0 1 k /GS1 gs 0.091 Tw [( / F)10(ed)17(y)22(anin)]TJ /Span<>> BDC ( )Tj EMC [(M.Y)35(u., Gl)-15.9(adkov)]TJ /Span<>> BDC ( )Tj EMC [(O.A., Gor)-24(deev)]TJ /Span<>> BDC ( )Tj EMC [(S.S., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj -0.02 Tw T* [(P)35(r)-33(a)-17(c)-16(t)-32(ical r)-23.9(ecommend)42(a)15(t)-32(ions for dr)-22(ug tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC (cancer of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he col)30.1(on, )]TJ 0.089 Tw T* [(r)-24(ec)-16(t)17.1(osigmoid junc)-16(t)-32(ion and r)-24(ec)-16(tum. )]TJ /T1_2 1 Tf (Malignant tumors.)Tj /T1_1 1 Tf ( 2022;12\(3s2-)Tj 0.005 Tc 0.349 Tw T* [(1)0.5(\))0.6(:)0.5(4)0.6(0)0.5(1)0.6(\226)0.5(4)0.6(5)0.5(4)0.6(.)0.5( \()0.5(I)0.6(n)0.5( R)0.6(u)0.5(s)0.6(s)0.5(.)0.6(\))0.6(.)0.5( d)-15.5(o)0.6(i)0.5(:)]TJ /Span<>> BDC 12.529 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw [(1)0.5(0)0.6(.)0.5(1)0.6(8)0.5(0)0.6(2)0.5(7)0.5(/)0.6(2)0.5(2)0.6(2)0.5(4)0.6(-)0.5(5)0.6(0)0.5(5)0.6(7)0.5(-)0.6(2)0.5(0)0.6(2)0.5(2)0.6(-)0.5(1)0.6(2)0.5(-)0.6(3)0.5(s)0.6(2)0.5(-)]TJ 0 Tc 0 Tw -12.529 -1.25 Td (401-454)Tj 0 0 0 1 k /GS1 gs 0.094 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\214\016\007\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \203\036\030\f\036\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \205\036\007\016\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\224. \025\024\n\002\017\027\017\030\024\r\026\027\027\026\016 )Tj -0.14 Tw -1.296 -1.25 Td (\017\n\n\031\027\024\021\036\030\026\023\017\016 \022\024\035\024\030\036\ \022\021\026\035\034\027\024\020\024 \030\026\022\026 \031)Tj /Span<>> BDC ( )Tj EMC (\n\024\035\024\007\024\005 \023\026\006\017\036\027\021\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024)Tj 0 Tw (-)Tj -0.026 Tw T* (\f\026\021\021\036\035\017\021\027\024\005 \027\036\f\021\026\002\017\035\ \034\027\024\f\021\034\033 \(\022\035\017\027\017\004\036\f\022\017\005 \ \f\035\031\004\026\005\). )Tj /T1_2 1 Tf 0 Tw (\215\027\030\022\006\022\025\024\n\022\235 )Tj T* (\020\f\203\020\021\022\023)Tj /T1_1 1 Tf 0.024 Tw [(. 2021;\(10\):16\22621. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33667/2078-5631-2021-10-16-)Tj T* (21)Tj 0 0 0 1 k /GS1 gs 0.081 Tw [( / L)70(y)22(ad)-16(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M.A., Ner)-9.9(sesov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(T.A., F)10(ed)17(y)22(anin)]TJ /Span<>> BDC ( )Tj EMC [(M.Y)35(u. Combined immu)]TJ 0 Tw (-)Tj 0.026 Tw T* [(no)17(t)-13(her)-32.9(apy of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-23.9(ec)-16(t)15(al cancer in young p)32(a)15(t)-31.9(ients wi)-24(t)-12.9(h micr)-32(osa)15(tell)-30.9(i)-24(te )]TJ 0.191 Tw T* [(inst)15(abil)-30.9(i)-24(t)-10(y )0.5(\(cl)-31(inical )0.5(case\). )]TJ /T1_2 1 Tf 11.191 0 Td [(Medical )0.5(alphabet.)]TJ /T1_1 1 Tf [( )0.5(2021;\(10\):16\22621. )0.5(\(In )]TJ 0.023 Tw -11.191 -1.25 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33667/2078-5631-2021-10-16-21)Tj 0 0 0 1 k /GS1 gs 0.025 Tc 0.552 Tw 29.055 38.75 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.371 0 Td (\210\020\026\027\016\027)Tj /Span<>> BDC ( )Tj EMC (\025.\202., \204\031\f\026\036\035\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\024\021\017\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)25( )]TJ 0.029 Tc 0.689 Tw -1.371 -1.25 Td (\204\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\ \036\f\022\026\016 \b\026\030\026\022\021\036\030\017\f\021\017\022\026 \ \022\024\035\024\030\036\022\021\026\035\034\027\024)Tj 0 Tc 0 Tw (-)Tj 0.017 Tc 0.349 Tw T* (\020\024 \030\026\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\021\026\021\031\f\026 \n\017\ \022\030\024\f\026\021\036\035\035\017\021\027\024\005 \027\036\f\021\026\ )Tj 0 Tc 0 Tw (-)Tj 0.042 Tc -0.042 Tw T* (\002\017\035\034\027\024\f\021\017. )Tj /T1_2 1 Tf 1.135 Tw 6.409 0 Td (\215\027\030\022\006\022\025\024\n\022\235 \024\031\021\027\023.)Tj /T1_1 1 Tf [( 2022;16\(9\):139\226146.)42( )]TJ 0.02 Tc -0.02 Tw -6.409 -1.25 Td [(d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.284 0 Td (10.21518/2079-701X-2022-16-9-139-146)Tj 0 0 0 1 k /GS1 gs 0.361 Tw [( / Ogany)22.3(an)]TJ /Span<>> BDC ( )Tj EMC [(K.A.,)20( )]TJ 0.01 Tc 0.075 Tw -2.284 -1.25 Td [(Musael)35(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.A., K)25(o)17(t)-32(ikov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M.A., e)-12(t al. M)-23.9(olecul)-16(ar gene)-12(t)-32(ic char)-33(a)-17(c)-16(ter)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj 0.01 Tc -0.024 Tw -27.286 -1.25 Td [(ist)-32(ics of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-16(t)15.1(al cancer depending on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(st)15(a)15(tus of)]TJ /Span<>> BDC ( )Tj EMC [(micr)-32(osa)15(tell)-31(i)-24(te)10( )]TJ -0.01 Tw T* [(inst)15(abil)-31(i)-24(t)-9.9(y. )]TJ /T1_2 1 Tf 0.344 Tw 5.169 0 Td [(Meditsinskiy Sov)13(et.)]TJ /T1_1 1 Tf [( 2022;16\(9\):139\226146. \(In Russ.\))10( )]TJ -0.01 Tw -5.169 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.897 0 Td (10.21518/2079-701X-2022-16-9-139-146)Tj 0 0 0 1 k /GS1 gs 0 Tc -0.043 Tw -1.897 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)16(yr)-37(iam Chal)-16(abi, F)20(anchi)]TJ /Span<>> BDC ( )Tj EMC [(LF, Dijk)-10(str)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(KK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Neoad)17(juv)-15(ant immuno)]TJ 0 Tw (-)Tj 0.01 Tw -1.296 -1.25 Td [(t)-13(her)-32.9(apy leads )0.5(t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-13(hol)30(o)-15.9(gical )0.5(r)-24(esponses )0.5(in )0.5(MMR-p)25(r)-32(of)-28(ic)-23.9(ient and )0.5(MMR-)]TJ 0.124 Tw T* [(def)-28(ic)-24(ient )0.6(ear)-30(l)35(y-st)15.1(a)-17(ge )0.5(col)30.1(on )0.5(cancer)-10(s. )]TJ /T1_2 1 Tf 15.08 0 Td [(N)18(at )0.6(Med.)]TJ /T1_1 1 Tf [( )0.6(2020 )0.5(Ap)25(r;26\(4\):566\226)]TJ 0.341 Tw -15.08 -1.25 Td [(576. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41591-020-0805-8)Tj 0 0 0 1 k /GS1 gs 0.341 Tw [( Epub 2020 Ap)25.1(r 6. PMID: )]TJ 0 Tw T* (32251400.)Tj 0.16 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(ahma)]TJ /Span<>> BDC ( )Tj EMC [(OE, Y)40(o)17(t)-13(her)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC (G, Hong)Tj /Span<>> BDC ( )Tj EMC [(T)25(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. 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V)0.7(l)3.3(a)-4.5(d)1.5(i)8.4(m)5.8(i)9.4(r)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)24.9(y)3.9(a)-4.5(d)-1(o)-0.6(v)33.6(, D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(F)17.7(e)-8.7(d)-1(o)1.4(r)-35.3(i)8.4(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf 1.275 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.5(n)-4.6(d p)-3.8(r)-5.9(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e m)1.8(a)-8.4(t)-15.2(e)]TJ 0 Tw 21.758 0 Td (-)Tj -0.005 Tc 0.005 Tw -21.758 -1.218 Td [(r)-53(ia)-6.5(l)-27.5(:)]TJ /T1_3 1 Tf 0 Tc 0.915 Tw 1.679 0 Td [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.7(a)1.8(u)-1.6(z)12.4(o)-1.1(l)-6.3(k)12.9(o)-0.6(v)33.6(, M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)24.9(y)3.8(a)-4.5(d)-1(o)-0.6(v)10.9(a)-14(, )]TJ 0 Tw -1.679 -1.218 Td [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)2.8(l)4.3(i)7.9(k)12.9(ov)10.7(a)-13.9(, D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(i)3.4(i V)53.2(. E)22(r)-40.2(y)3(g)-14.5(i)8.4(n)-6(, E)20.7(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i V)53.1(. L)-3.5(e)-8.7(d)1.4(i)8.4(n)]TJ /T1_1 1 Tf -0.007 Tc 1.43 Tw 0 -1.218 TD [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.423 Tw 10.512 0 Td [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.6(a)1.8(u)-1.6(z)12.4(o)-1.1(l)-6.3(k)12.9(ov)33.6(, )]TJ 0 Tw -10.512 -1.218 Td [(M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(L)24.9(y)3.8(a)-4.5(d)-1(o)-0.6(v)10.9(a)-14(, V)0.7(l)3.3(a)-4.5(d)1.4(i)8.4(m)5.9(i)9.4(r K)-13.6(. L)24.9(y)3.8(a)-4.4(d)-1(o)-0.6(v)]TJ /T1_1 1 Tf -0.083 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.6(a)1.8(u)-1.6(z)12.4(o)-1.1(l)-6.3(k)12.9(o)-0.6(v)33.6(, M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)24.9(y)3.8(a)-4.5(d)-1(o)-0.6(v)10.8(a)-14(, )]TJ -0.001 Tc 0.001 Tw 0 -1.218 TD [(Vl)2.3(a)-5.5(di)7.4(m)4.8(i)8.4(r)-1( K)-14.5(.)-1( L)23.9(y)2.8(a)-5.5(d)-2(o)-1.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.658 Tw 3.238 0 Td [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.6(a)1.8(u)-1.6(z)12.5(o)-1.1(l)-6.3(k)12.9(o)-0.6(v)33.6(, V)0.7(l)3.3(a)-4.5(d)1.4(i)8.4(m)5.9(i)9.4(r)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)24.9(y)3.8(a)-4.5(d)-1(o)-0.6(v)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(F)17.8(e)-8.7(d)-1(o)1.3(r)-35.3(i)8.4(n)1.9(o)-0.6(v)33.6(, J)11.3(u)2.8(l)4.3(i)5.9(a S)2.1(. M)5.2(a)-0.8(n)8.1(s)11.2(u)6.1(r)2.4(o)-0.6(v)10.8(a)-14(, D)-2(m)5.9(i)0.9(t)-5.4(r)-35.3(i)3.4(i V)53.1(. E)22.1(r)-40.2(y)3(g)-14.5(i)8.4(n)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.229 Tw 0 -1.218 TD (\003\026\031\024\035\022\024\r \210\035\036\020 \203\017\022\024\035\026\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \024\021\007\036)Tj 0 Tw (-)Tj 0.063 Tw T* (\035\036\027\017\016 \b\017\n\017\024\021\036\030\026\023\017\017 \2231 \ \253\210\027\022\024\035\024\020\017\004\036\f\022\017\005 \006\036\027\021\ \030 \2231 )Tj 0.058 Tw 0 -1.218 TD (\206\024\030\024\007\f\022\024\005 \022\035\017\027\017\004\036\f\022\024\ \005 \002\024\035\034\027\017\006\t \017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 )Tj 0.541 Tw 0 -1.218 TD (\212\036\023\026\030\021\026\n\036\027\021\026 \007\030\026\r\024\024\b\ \030\026\027\036\027\017\016 \020\024\030\024\007\026 \204\024\f\022\r\t\ \273; )Tj 0 Tw 0 -1.218 TD (ORCID 0009-0003-7903-9118)Tj 0.545 Tw 0 -1.218 TD [(\214\016\007\024\r\026 )0.5(\204\026\030\017\027\026 )0.6(\202\035\036\022\f\026\027\007\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.756 0 Td [(\227 )0.5(\022.\n.\027., )0.6(\026\r\036)]TJ 0 Tw (-)Tj 0.728 Tw -14.756 -1.218 Td [(\007\031\033\013\026\016 )0.6(\b\017\n\017\024\021\036\030\026\023\036\r\021\017\004\036\f\022\017\n )0.5(\024\021\007\036\035\036\027\017\036\n )0.5(\2231, )]TJ 0.063 Tw 0 -1.218 TD [(\253\210\027\022\024\035\024\020\017\004\036\f\022\017\005 )0.6(\006\036\027\021\030 )0.5(\223 )0.6(1 )0.5(\206\024\030\024\007\f\022\024\005 )0.5(\022\035\017\027\017\004\036\f\022\024\005 )]TJ 0.394 Tw T* (\002\024\035\034\027\017\006\t \017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 \212\036\023\026\030\021\026\n\036\027\021\026 \007\ \030\026)Tj 0 Tw (-)Tj 0.289 Tw T* (\r\024\024\b\030\026\027\036\027\017\016 \020\024\030\024\007\026 \204\024\ \f\022\r\t\273; \026\f\f\017\f\021\036\027\021 \022\026\235\036\007\030\t\ , )Tj 0.38 Tw 0 -1.218 TD [(\203\024\r\024\022\031\027\036\006\022\017\005 )0.6(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.6(\017\027\f\021\017\021\031\021 )0.5(\031\f\024\r\036\030)]TJ 0 Tw (-)Tj 0.164 Tw 0 -1.218 TD (\001\036\027\f\021\r\024\r\026\027\017\016 \r\030\026\004\036\005)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \217\024\f\f\017\005\f\022\024\005 \n\036\007\ \017)Tj 0 Tw (-)Tj 0.101 Tw 0 -1.218 TD [(\006\017\027\f\022\024\005 )0.6(\026\022\026\007\036\n\017\017 )0.5(\027\036\023\030\036\030\t\r\027\024\020\024 )0.5(\023\030\024\235\036\f\f\017\024\027\026\035\034\027\024)]TJ 0 Tw (-)Tj 0 -1.218 TD (\020\024 \024\002\030\026\024\r\026\027\017\016; ORCID 0000-0002-9558-5\ 579)Tj 0.166 Tw 0 -1.218 TD (\214\016\007\024\r \200\035\026\007\017\n\017\030 \025\024\027\f\021\026\ \027\021\017\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD [(\033\013\017\005 )0.6(\024\021\007\036\035\036\027\017\036\n )0.5(\024\027\022\024\035\024\020\017\017 )0.6(\223 )0.5(4, )0.5(\253\210\027\022\024\035\024\020\017\004\036\f\022\017\005 )]TJ 0.179 Tw 0 -1.218 TD (\006\036\027\021\030 \2231 \206\024\030\024\007\f\022\024\005 \022\035\017\ \027\017\004\036\f\022\024\005 \002\024\035\034\027\017\006\t \017\n\036\ \027\017 )Tj 0.256 Tw 0 -1.218 TD (\222.\222.)Tj /Span<>> BDC ( )Tj EMC [(\224\007\017\027\026 \212\036\023\026\030\021\026\n\036\027\021\026 )0.5(\007\030\026\r\024\024\b\030\026\027\036\027\017\016 \020\024\030\024\007\ \026 )]TJ 0.14 Tw 23.244 60.89 Td (\204\024\f\022\r\t\273; \023\030\024\235\036\f\f\024\030 \022\026\235\036\ \007\030\t \024\027\022\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\035\017\026)Tj 0 Tw (-)Tj 0.135 Tw T* (\021\017\r\027\024\005 \n\036\007\017\006\017\027\t \017\n\036\027\017 \026\ \022\026\007\036\n\017\022\026 \230.\202.)Tj /Span<>> BDC ( )Tj EMC (\222\026\r\017\006\022\024\020\024, )Tj 0.547 Tw T* [(\205\206\207\210\211 \212\215\210 \253\217\024\f\f\017\005\f\022\026\016\ )0.5(\n\036\007\017\006\017\027\f\022\026\016 \026\022\026\007\036\n\017\016 \ )]TJ 0.805 Tw T* (\027\036\023\030\036\030\t\r\027\024\020\024 \023\030\024\235\036\f\f\017\ \024\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026\027\017\ \016\273 )Tj 0.499 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017, \026\r\036\007\031\ \033\013\017\005 \022\026\235\036\007\030\024\005 \024\027\022\024)Tj 0 Tw (-)Tj 0.583 Tw T* (\035\024\020\017\017, \203\024\r\024\022\031\027\036\006\022\017\005 \020\ \024\f\031\007\026\030\f\021\r\036\027\027\t\005 \017\027\f\021\017\021\031\ \021 )Tj 0.158 Tw 0 -1.218 TD [(\031\f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\017\016 )0.5(\r\030\026\004\036\005)]TJ /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \217\024\f\f\017\005\f\022\024\005 )Tj 0.55 Tw 0 -1.218 TD (\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\036\n\017\017 \ \027\036\023\030\036\030\t\r\027\024\020\024 \023\030\024\235\036\f\f\017\ )Tj 0 Tw (-)Tj 0.503 Tw T* (\024\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026\027\017\ \016; SPIN: 5385-7889, ORCID )Tj 0 Tw T* (0000-0002-7281-3591)Tj 0.004 Tc 0.326 Tw T* (\205\036\007\024\030\017\027\024\r \212\036\027\017\f \222\036\030\020\036\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \024\021)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 1.062 Tw T* [(\007\036\035\036\027\017\016 )0.6(\b\017\n\017\024\021\036\030\026\023\017\017 )0.5(\2231, )0.5(\253\210\027\022\024\035\024\020\017\004\036\f\022\017\005)4( )]TJ 0.144 Tw 0 -1.218 TD [(\006\036\027\021\030 \2231 \206\024\030\024\007\f\022\024\005 \022\035\017\ \027\017\004\036\f\022\024\005 \002\024\035\034\027\017\006\t \017\n\036\ \027\017)4( )]TJ 0.211 Tw 0 -1.218 TD (\222.\222.)Tj /Span<>> BDC ( )Tj EMC [(\224\007\017\027\026 \212\036\023\026\030\021\026\n\036\027\021\026 \007\ \030\026\r\024\024\b\030\026\027\036\027\017\016 \020\024\030\024\007\026\ )3.9( )]TJ 0.2 Tw 0 -1.218 TD (\204\024\f\022\r\t\273; \026\f\f\017\f\021\036\027\021 \022\026\235\036\007\ \030\t \024\027\022\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\035\017\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.098 Tw T* (\021\017\r\027\024\005 \n\036\007\017\006\017\027\t \017\n\036\027\017 \026\ \022\026\007\036\n\017\022\026 \230.\202.)Tj /Span<>> BDC ( )Tj EMC [(\222\026\r\017\006\022\024\020\024,)4( )]TJ 0.506 Tw T* [(\205\206\207\210\211 \212\215\210 \253\217\024\f\f\017\005\f\022\026\016\ \n\036\007\017\006\017\027\f\022\026\016 \026\022\026\007\036\n\017\016\ )3.9( )]TJ 1.541 Tw T* (\027\036\023\030\036\030\t\r\027\024\020\024 \023\030\024\235\036\f\f\017\ \024\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.357 Tw T* [(\027\017\016\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; S\ PIN: 1079-8460, ORCID)4( )]TJ -0.004 Tw T* (0000-0001-5516-7367)Tj 0 Tc 0.404 Tw T* (\025\031\035\017\022\024\r\026 \213\r\020\036\027\017\016 \202\035\036\022\ \f\026\027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \026\r\036\007\031\033\013\026\016 )Tj 0.205 Tw T* [(\024\021\007\036\035\036\027\017\036\n )0.6(\035\031\004\036\r\024\005 )0.5(\007\017\026\020\027\024\f\021\017\022\017, )0.6(\253\210\027\022\024\035\024\020\017\004\036\f\022\017\005 )]TJ 0.928 Tw T* (\006\036\027\021\030 \2231 \206\024\030\024\007\f\022\024\005 \022\035\017\ \027\017\004\036\f\022\024\005 \002\024\035\034\027\017\006\t )Tj 0.604 Tw T* (\017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 \212\036\023\026\030\021\026\n\036\027\021\026 \007\ \030\026\r\024\024\b\030\026\027\036)Tj 0 Tw (-)Tj 0.643 Tw T* (\027\017\016 \020\024\030\024\007\026 \204\024\f\022\r\t\273; SPIN: 2884\ \2264803, ORCID )Tj 0 Tw T* (0000-0002-0319-4934)Tj -0.126 Tw T* (\213\030\t\020\017\027 \212\n\017\021\030\017\005 \200\026\035\036\030\034\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031\033\013\017\005 \024\021)Tj 0 Tw (-)Tj -0.014 Tw T* (\007\036\035\036\027\017\036\n \024\027\022\024\035\024\020\017\017 \223\ 2, \253\210\027\022\024\035\024\020\017\004\036\f\022\017\005 \006\036\027\ \021\030 \2231 )Tj 0.058 Tw T* (\206\024\030\024\007\f\022\024\005 \022\035\017\027\017\004\036\f\022\024\ \005 \002\024\035\034\027\017\006\t \017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 )Tj 0.541 Tw T* (\212\036\023\026\030\021\026\n\036\027\021\026 \007\030\026\r\024\024\b\ \030\026\027\036\027\017\016 \020\024\030\024\007\026 \204\024\f\022\r\t\ \273; )Tj 0 Tw T* (SPIN: 3155-6227, ORCID 0000-0002-7278-8525)Tj 0.483 Tw T* (\214\036\007\017\027 \213\r\020\036\027\017\005 \200\017\021\026\035\034\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \030\031\022\024\r\024\007\017)Tj 0 Tw (-)Tj 0.61 Tw T* [(\021\036\035\034 \006\036\027\021\030\026 \b\017\n\017\024\021\036\030\026\ \023\017\017, )0.5(\026\r\036\007\031\033\013\017\005 \b\017\n\017\024)]TJ 0 Tw (-)Tj 0.531 Tw T* (\021\036\030\026\023\036\r\021\017\004\036\f\022\017\n \024\021\007\036\035\ \036\027\017\036\n, \025\035\017\027\017\004\036\f\022\024\005 \002\024\035\ \034)Tj 0 Tw (-)Tj 0.481 Tw T* (\027\017\006\t \2232 \202\210 \253\206\030\031\023\023\026 \022\024\n\023\ \026\027\017\005 \204\036\007\f\017\273; ORCID )Tj 0 Tw T* (0000-0002-1834-0981)Tj 0.156 Tw T* (\204\026\027\f\031\030\024\r\026 \224\035\017\016 \222\036\030\020\036\036\ \r\027)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\024\027\022\024\035\024\020 \024\021\007\036\035\036\ )Tj 0 Tw (-)Tj 0.251 Tw T* (\027\017\016 \b\017\n\017\024\021\036\030\026\023\017\017 \2231 \253\210\ \027\022\024\035\024\020\017\004\036\f\022\017\005 \006\036\027\021\030 \ \2231 )Tj 0.058 Tw T* (\206\024\030\024\007\f\022\024\005 \022\035\017\027\017\004\036\f\022\024\ \005 \002\024\035\034\027\017\006\t \017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 )Tj 0.541 Tw T* (\212\036\023\026\030\021\026\n\036\027\021\026 \007\030\026\r\024\024\b\ \030\026\027\036\027\017\016 \020\024\030\024\007\026 \204\024\f\022\r\t\ \273; )Tj 0 Tw T* (ORCID 0009-0003-5294-1697)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Oleg N. Z)10.1(auzolkov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0003-7903-9118)Tj T* [(Mar)-37(ina A. L)70.1(y)22(ad)-16(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9558-5579)Tj T* [(Vl)-16(adimir K. L)70.1(y)22(ad)-16(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7281-3591)Tj T* [(Denis S. F)10.1(ed)-16(or)-37(inov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5516-7367)Tj T* [(Ev)-21(geniy)22(a A. K)25.1(ul)-31(ikov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0319-4934)Tj T* [(Dmi)-24(tr)-36.9(i)-16(i V. Er)-23.9(ygin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7278-8525)Tj T* [(Ev)-21(geni)-16(i V. L)35.1(edin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1834-0981)Tj T* [(Jul)-31(ia S. Mansur)-31.9(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0003-5294-1697)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.8646 56.0378 Tm (45)Tj ET endstream endobj 1523 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.038 Tw 10 0 0 10 70.8661 347.3119 Tm (\027\026\004\017\021\036\035\034\027\024\020\024 \(\023\024\035\027\024\ \020\024 \017\035\017 \023\024\004\021\017 \023\024\035\027\024\020\024\)\ \023\026\021\024\n\024\030)Tj 0 Tw (-)Tj 0 -1.218 TD (\235\024\035\024\020\017\004\036\f\022\024\020\024 \024\021\r\036\021\026\ .)Tj 0.435 Tw T* (NRG-GI002 \(NCT02921256\))Tj /Span<>> BDC ( )Tj EMC (\227 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\036 )Tj 0.162 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 II \235\026\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\033 \220\235\235\036\022\021\017\r\027\024\f\021\ \017 )Tj 0.152 Tw T* (\r\036\035\017\023\026\030\017\002\026 \017\035\017 \023\036\n\002\030\024\ \035\017\031\n\026\002\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tw (-)Tj -0.003 Tw T* (\n\017\024\021\036\030\026\023\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\036\r\024\005 \021\036\030\026\023\017\036\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021)Tj 0 Tw (-)Tj 0.055 Tw T* (\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n \030\026\ \022\024\n \023\030\016\n\024\005 \022\017\001\022\017 \(\204\217\217\215\ \025\). )Tj 0.129 Tw T* (\215\036\030\r\017\004\027\024\005 \022\024\027\036\004\027\024\005 \021\ \024\004\022\024\005 \016\r\035\016\035\026\f\034 \004\026\f\021\024\021\ \026 \023\024\f\021)Tj 0 Tw (-)Tj 0.21 Tw T* (\021\036\030\026\023\036\r\021\017\004\036\f\022\024\020\024 \017\n\036\ \027\036\027\017\016 \f\021\026\007\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\n\017 )Tj 0.16 Tw T* (\022\024\027\036\004\027\t\n\017 \021\024\004\022\026\n\017 \016\r\035\016\ \035\017\f\034 \210\200, \200\207\215, \021\024\022\f\017\004\027\024\f\021\ \034, )Tj 0.05 Tw T* (\215\215\210, \023\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\ \005 \024\021\r\036\021 \(\215\025\210\) \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \r\t)Tj 0 Tw (-)Tj 0.813 Tw T* (\023\024\035\027\036\027\017\016 \f\235\017\027\022\021\036\030\024\f\002\ \036\030\036\020\026\033\013\017\b \b\017\030\031\030\020\017\004\036\f\022\ \017\b )Tj 0.113 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r. 185 \023\026\006\017\036\027\021\ \024\r \002\t\035\017 \030\026\027\007\024\n\017\017\030\024\r\026)Tj 0 Tw (-)Tj 0.114 Tw T* (\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031 \023\036\n\002\030\024\035\017\031\n\026\002\026\ \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.114 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90\) \017\035\017 \022\024\027\021\030\024\035\016 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf 0.15 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (95\) [9]. \217\026\035\017\004\017\005 \023\024\f\021\021\036\030\026\023\ \036\r\021\017\004\036\f\022\024\005 \f\021\026\007\017\017 )Tj -0.04 Tw T* (\017\035\017 \004\026\f\021\024\021\t \215\215\210 \r\t\016\r\035\036\027\ \024 \027\036 \002\t\035\024, \200\207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\210\200 \027\036 \002\t\035\017 )Tj 0 Tw T* (\007\024\f\021\017\020\027\031\021\t.)Tj 0.11 Tw T* [(VOL)75(T)35(A)16(GE \(NCT02948348\))]TJ /Span<>> BDC ( )Tj EMC (\227 \024\021\022\030\t\021\024\036 \024\007\027\024\020\030\031\023\023\ \024\r\024\036 )Tj 0.093 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 \235\026\t Ib/II, \023\030\024\ \r\024\007\017\n\024\036 \007\035\016 \017\031\004\036\027\017\016 )Tj 0.463 Tw T* [(\002\036\024\023\026\f\027\024\f\021\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.556 0 Td [(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024)]TJ 0 Tw (-)Tj 0.296 Tw -7.556 -1.218 Td (\020\024 \017\f\023\024\035\034\024\r\026\027\017\016 \027\036\024\026\007\ \255\033\r\026\027\021\027\024\005 \017\n\n\031\027\024\021\036\030\026\023\ \017\017 )Tj 0.216 Tw T* (\023\024\f\035\036 \b\017\n\017\024\035\031\004\036\r\024\005 \021\036\030\ \026\023\017\017 \022\026\023\036\006\017\021\026\002\017\027\024\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.584 Tw T* (\f\035\036\007\031\033\013\036\020\024 \024\023\036\030\026\021\017\r\027\ \024\020\024 \035\036\004\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.328 Tw 23.244 26.792 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \t\n \030\036\036\022\021\026\002\036\035\034\027\t\n \030\026\022\024\n\ )Tj -0.025 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \211)Tj /Span<>> BDC ( )Tj EMC (3 \017)Tj /Span<>> BDC ( )Tj EMC (5 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (dMMR/MSI \024\023\031\b\024)Tj 0 Tw (-)Tj 0.07 Tw T* (\035\016\n\017 \002\t\035 \007\024\f\021\017\020\027\031\021 \023\024\035\ \027\t\005 \017\035\017 \023\024\004\021\017 \023\024\035\027\t\005 \023\ \026\021\024)Tj 0 Tw (-)Tj T* (\n\024\030\235\024\035\024\020\017\004\036\f\022\017\005 \024\021\r\036\021\ [10].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 274.2439 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.564 Tw 10 0 0 10 303.3071 249.8879 Tm (\217\036\031\035\034\021\026\021\t \r\t\001\036\023\030\017\r\036\007\036\ \027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, \022\026\022 )Tj 0.02 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \026\002\024\035\036\r\026\027\017\016 \031\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\027\t\b \027\026\n\017 \023\026\006\017\036\027\021\ \024\r, )Tj 0.031 Tw T* [(\023\024\007\021\r\036\030\032\007\026\036\021 )0.6(\r\t\f\024\022\031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\230\025\221\230 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 19.768 0 Td (\023\026\006\017)Tj 0 Tw (-)Tj 0.216 Tw -19.768 -1.218 Td (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \t\n dMMR/MSI \030\026\022\024\n )Tj 0.061 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. \212\026\027\027\t\005 \ \021\036\030\026\023\036\r\021\017\004\036\f\022\017\005 \023\024\007\b\024\ \007 \023\024)Tj 0 Tw (-)Tj 0.161 Tw T* [(\r\024\035\017\035 )0.5(\027\026\n \017\002\036\032\026\021\034 )0.5(\024\023\036\030\026\006\017\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 14.663 0 Td [(2 \023\026\006\017\036\027\021\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.948 0 Td (3 )Tj 0.252 Tw -21.61 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\002\017\021\034\f\016 \023\024\035\027\024\005 \235\031\027\022\ \006\017\024\027\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\006\017\026\035\034\027\024\005 )Tj 0 Tw T* (\030\036\026\002\017\035\017\021\026\006\017\017 \023\026\006\017\036\027\ \021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 128.1078 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.005 Tw 10 0 0 10 303.3071 103.7519 Tm (\230\n\n\031\027\024\021\036\030\026\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \230\025\221\230 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\026\006\017\036\027\021\024\r )Tj -0.004 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \t\n, \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004. \027\036\030\036\036\022\021\026\002\036\035\034\027\t\n, )Tj -0.008 Tw T* (\030\026\022\024\n \021\024\035\f\021\024\005 \022\017\001\022\017 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \n\017\022\030\024\f\026\021\036\035\035\017\ \021\027\024\005 )Tj /T1_3 1 Tf 0 Tw -13.707 64.543 Td (\021\f\t\b\t\201\r\217\220\t\r \t\217\217\f\r\240\002\004\b\t\235 \234\226\ \226\r\220\003\t\b\002\217\003\t \t\214\214\210\b\002\003\r\006\004\212\ \t\t)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8662 720.3279 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 71.1162 699.2587 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 116.4705 720.3279 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 116.4705 699.2587 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 167.4941 720.3279 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 167.4941 699.2587 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 365.9193 720.3279 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 365.9193 699.5087 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 414.1083 720.3279 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 462.2972 720.3279 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 462.2972 699.5087 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6595 699.2587 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 71.1162 688.0394 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 116.4705 688.0394 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 167.4941 688.0394 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 365.6693 699.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 365.9193 688.0394 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 414.1083 699.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 414.1083 688.0394 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 462.2972 688.0394 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6595 688.0394 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8662 687.7894 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 71.1162 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 116.4705 687.7894 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 116.4705 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 167.4941 687.7894 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 167.4941 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 365.9193 687.7894 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 365.9193 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 414.1083 687.7894 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 414.1083 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 462.2972 687.7894 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 462.2972 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 524.6595 621.2822 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 70.8662 621.0322 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 71.1162 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 116.4705 621.0322 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 116.4705 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 167.4941 621.0322 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 167.4941 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 365.9193 621.0322 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 365.9193 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 414.1083 621.0322 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 414.1083 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 462.2972 621.0322 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 462.2972 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 524.6595 561.917 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 70.8662 561.667 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 71.1162 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 116.4705 561.667 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 116.4705 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 167.4941 561.667 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 167.4941 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 365.9193 561.667 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 365.9193 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 414.1083 561.667 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 414.1083 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 462.2972 561.667 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 462.2972 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 524.6595 502.5518 cm 0 0 m 0 58.865 l S Q q 1 0 0 1 70.8662 502.3018 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 71.1162 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 116.4705 502.3018 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 116.4705 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 167.4941 502.3018 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 167.4941 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 365.9193 502.3018 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 365.9193 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 414.1083 502.3018 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 414.1083 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 462.2972 502.3018 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 462.2972 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 524.6595 435.7946 cm 0 0 m 0 66.257 l S Q q 1 0 0 1 70.8662 435.5446 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 71.1162 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 116.4705 435.5446 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 116.4705 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 167.4941 435.5446 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 167.4941 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 365.9193 435.5446 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 365.9193 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 414.1083 435.5446 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 414.1083 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 462.2972 435.5446 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 462.2972 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 524.6595 380.763 cm 0 0 m 0 54.532 l S Q q 1 0 0 1 70.8662 380.513 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 116.4705 380.513 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 167.4941 380.513 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 365.9193 380.513 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 414.1083 380.513 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 462.2972 380.513 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 77.4176 701.1587 Tm (\034\217\003\002\201\b\t\220)Tj 5.247 1.2 Td (\017\206\227\r\r \201\t\217\f\002 )Tj 0.531 -1.2 Td (\212\004\204\t\r\b\003\002 )Tj 1.42 -1.2 Td (\004\206\217.)Tj 13.262 1.2 Td (C\216\r\214\004 \f\r\201\r\b\t\235)Tj 17.337 1.317 Td (\017\206\233\r\220\003\t\b\013\005 \002\003\r\003 )Tj 1.86 -1.2 Td (\b\004)Tj /Span<>> BDC ( )Tj EMC (\f\r\201\r\b\t\r)Tj 10.913 1.083 Td (\017\206\227\004\235 )Tj -2.008 -1.2 Td (\013\202\t\214\004\r\214\002\217\003\001, )Tj 2.519 -1.2 Td (\214\r\217.)Tj -14.57 -0.117 Td (\200\022, \004\206\217 \(%\))Tj 6.036 0 Td (\030\022, \004\206\217 \(%\))Tj /T1_0 1 Tf -42.981 -1.433 Td (Chalabi M., )Tj 0 -1.2 TD (2020 [8])Tj 7.226 1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (21)Tj 4.821 -0.354 Td ( 1 \r\r\036\007\036\027\017\036 2 \r\r\036\007\036\027\ \017\036)Tj 1.301 -1.164 Td (\230\023\017\035\017\n\031\n\026\002 )Tj 0.756 -1.2 Td (1 \n\020/\022\020 + )Tj -0.391 -1.2 Td (\027\017\r\024\035\031\n\026\002 )Tj -0.579 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\n\020/\022\020 \r 1 \227 )Tj 1.854 -1.2 Td (\007\036\027\034)Tj ET 4 M 176.248 626.952 50.524 47.527 re S 1 w q 1 0 0 1 227.0217 649.2539 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 246.8643 649.2539 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 254.1242 657.4189 Tm (\203\017\r\024\035\031\n\026\002 )Tj -0.162 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\n\020/\022\020 \r 15 )Tj 0.871 -1.2 Td (\227 \007\036\027\034)Tj ET 0.5 w 247.114 626.952 50.524 47.527 re S 1 w q 1 0 0 1 297.8878 649.2539 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 317.7304 649.2539 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 321.6251 647.8188 Tm (\210\023\036\030\026\006\017\016)Tj ET 0.5 w 317.98 626.952 39.185 47.527 re S BT /T1_0 1 Tf 8 0 0 8 375.3819 679.1628 Tm (12)Tj /Span<>> BDC ( )Tj EMC (\(57,0\))Tj 6.024 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(43,0\))Tj 5.833 0 Td (\203\036 \007\024\f\021\017\020\027\031\021\026)Tj -49.536 -8.345 Td (Rahma O.E., )Tj T* (2021 [9])Tj 7.226 1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90)Tj 6.67 -1.194 Td (FOLFOX6 )Tj 0.114 -1.2 Td (\022\026\032\007\t\036 )Tj -0.253 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\017 )Tj -0.372 -1.2 Td (\(8)Tj /Span<>> BDC ( )Tj EMC (\006\017\022\035\024\r\))Tj ET 173.413 567.586 50.524 47.527 re S 1 w q 1 0 0 1 224.1871 589.8887 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 244.0296 589.8887 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 263.3442 607.6536 Tm (\216\214\221 + )Tj -2.147 -1.2 Td (\215\036\n\002\030\024\035\017\031\n\026\002 )Tj 0.242 -1.2 Td (200 \n\020 \022\026\032\007\t\036 )Tj 1.2 -1.2 Td (3 \027\036\007\036\035\017 )Tj -0.371 -1.2 Td (\(6)Tj /Span<>> BDC ( )Tj EMC (\006\017\022\035\024\r\))Tj ET 0.5 w 244.28 567.586 56.193 47.527 re S 1 w q 1 0 0 1 300.7225 589.8887 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 320.565 589.8887 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 324.4597 588.4536 Tm (\210\023\036\030\026\006\017\016)Tj ET 0.5 w 320.815 567.586 39.185 47.527 re S BT /T1_0 1 Tf 8 0 0 8 375.3819 612.4056 Tm (29)Tj /Span<>> BDC ( )Tj EMC (\(31,9\))Tj 7.575 0 Td (\226)Tj 6.909 0 Td (\226)Tj -52.163 -7.421 Td (Tsukada Y., )Tj 0 -1.2 TD (2024 [10])Tj 7.476 1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5)Tj 7.706 -2.994 Td (\216\214\221 )Tj ET 176.248 508.221 50.524 47.527 re S 1 w q 1 0 0 1 227.0217 530.5234 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 246.8643 530.5234 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 254.1242 548.2884 Tm (\203\017\r\024\035\031\n\026\002 )Tj 0.944 -1.2 Td (240 \n\020 )Tj -0.243 -1.2 Td (\022\026\032\007\t\036 )Tj -0.253 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\017 )Tj -0.372 -1.2 Td (\(5)Tj /Span<>> BDC ( )Tj EMC (\006\017\022\035\024\r\))Tj ET 0.5 w 247.114 508.221 50.524 47.527 re S 1 w q 1 0 0 1 297.8879 530.5234 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 317.7304 530.5234 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 321.6251 529.0884 Tm (\210\023\036\030\026\006\017\016)Tj ET 0.5 w 317.98 508.221 39.185 47.527 re S BT /T1_0 1 Tf 8 0 0 8 377.382 553.0403 Tm (3)Tj /Span<>> BDC ( )Tj EMC (\(60,0\))Tj 7.325 0 Td (\226)Tj 4.282 0 Td (\203\036 \007\024\f\021\017\020\027\031\021\026)Tj -49.536 -7.421 Td (Chalabi M., )Tj 0 -1.2 TD (2024 [11])Tj 6.976 1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (111)Tj 5.071 -0.354 Td ( 1 \r\r\036\007\036\027\017\036 2 \r\r\036\007\036\027\ \017\036)Tj 1.301 -1.164 Td (\230\023\017\035\017\n\031\n\026\002 )Tj 0.756 -1.2 Td (1 \n\020/\022\020 + )Tj -0.757 -1.2 Td (\027\017\r\024\035\031\n\026\002 3 )Tj 0.154 -1.2 Td (\n\020/\022\020 \r 1 \227 )Tj 1.487 -1.2 Td (\007\036\027\034)Tj ET 176.248 441.464 50.524 47.527 re S 1 w q 1 0 0 1 227.0218 463.7656 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 246.8643 463.7656 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 254.1243 471.9311 Tm (\203\017\r\024\035\031\n\026\002 )Tj -0.162 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\n\020/\022\020 \r 15 )Tj 0.871 -1.2 Td (\227 \007\036\027\034)Tj ET 0.5 w 247.114 441.464 50.524 47.527 re S 1 w q 1 0 0 1 297.8879 463.7656 cm 0 0 m 14.38 0 l S Q q 1 0 0 1 317.7305 463.7656 cm 0 0 m -7.012 2.553 l -7.012 -2.551 l h f Q BT /T1_0 1 Tf 8 0 0 8 321.6252 462.3311 Tm (\210\023\036\030\026\006\017\016)Tj ET 0.5 w 317.98 441.464 39.185 47.527 re S BT /T1_0 1 Tf 8 0 0 8 375.382 493.675 Tm (75)Tj /Span<>> BDC ( )Tj EMC (\(68,0\))Tj 6.024 0 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(30,6\))Tj 5.833 0 Td (\203\036 \007\024\f\021\017\020\027\031\021\026)Tj -49.536 -8.345 Td (Cercek A., )Tj 0 -1.2 TD (2022 [12])Tj 7.226 1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (12)Tj 7.2781 0 0 7.2781 178.7238 422.8615 Tm (\212\024\f\021\026\030\035\017\n\026\002 )Tj 1.368 -1.2 Td (500 \n\020 )Tj -0.243 -1.2 Td (\022\026\032\007\t\036 )Tj -0.253 -1.2 Td (3 \027\036\007\036\035\017 )Tj -0.371 -1.2 Td (\(9)Tj /Span<>> BDC ( )Tj EMC (\006\017\022\035\024\r\))Tj ET 0.455 w 176.722 386.41 43.386 43.238 re S BT /T1_0 1 Tf 7.2781 0 0 7.2781 235.3303 405.394 Tm (\210\006\036\027\022\026)Tj ET 233.457 396.651 25.334 22.755 re S BT /T1_0 1 Tf 7.2781 0 0 7.2781 274.3659 416.0222 Tm (\216\214\221)Tj ET 272.406 411.148 15.018 15.018 re S BT /T1_0 1 Tf 7.2781 0 0 7.2781 274.708 394.7658 Tm (c\222R)Tj ET 272.406 389.891 15.018 15.018 re S BT /T1_0 1 Tf 7.2781 0 0 7.2781 298.8454 405.6425 Tm (c\222R)Tj ET 296.544 400.768 15.018 15.018 re S 0.91 w q 1 0 0 1 220.3349 408.0293 cm 0 0 m 7.564 0 l S Q q 1 0 0 1 233.2293 408.0293 cm 0 0 m -6.888 2.508 l -6.888 -2.506 l h f Q q 1 0 0 1 259.2915 409.4922 cm 0 0 m 8.757 6.59 l S Q q 1 0 0 1 272.3078 419.2871 cm 0 0 m -7.011 -2.139 l -3.997 -6.145 l h f Q q 1 0 0 1 259.2915 406.5664 cm 0 0 m 8.757 -6.59 l S Q q 1 0 0 1 272.3078 396.7715 cm 0 0 m -7.011 2.139 l -3.997 6.145 l h f Q q 1 0 0 1 287.6797 417.2148 cm 0 0 m 4.796 -4.07 l S Q q 1 0 0 1 296.5404 409.6953 cm 0 0 m -6.874 2.547 l -3.63 6.369 l h f Q q 1 0 0 1 311.7845 406.7637 cm 0 0 m 5.117 -4.154 l S Q q 1 0 0 1 321.0396 399.25 cm 0 0 m -6.928 2.396 l -3.768 6.287 l h f Q q 1 0 0 1 287.3855 421.6875 cm 0 0 m 28.195 0 l S Q q 1 0 0 1 320.9107 421.6875 cm 0 0 m -6.888 2.508 l -6.888 -2.506 l h f Q q 1 0 0 1 287.3855 394.2305 cm 0 0 m 28.195 0 l S Q q 1 0 0 1 320.9107 394.2305 cm 0 0 m -6.888 2.508 l -6.888 -2.506 l h f Q BT /T1_0 1 Tf 7.2781 0 0 7.2781 324.4063 418.2144 Tm (\210\023\036\030\026\006\017\016)Tj ET 0.455 w 321.138 412.051 35.554 17.597 re S BT /T1_0 1 Tf 5.8225 0 0 7.2781 323.8117 392.5735 Tm (\203\026\002\035\033\007\036\027\017\036)Tj ET 321.138 386.41 35.554 17.597 re S BT /T1_0 1 Tf 8 0 0 8 373.3821 426.9178 Tm (12)Tj /Span<>> BDC ( )Tj EMC (\(100,0\))Tj 7.825 0 Td (\226)Tj 4.282 0 Td (\203\036 \007\024\f\021\017\020\027\031\021\026)Tj /T1_1 1 Tf 7 0 0 7 70.8664 369.0282 Tm (\004\032\022\026\027\007\020\025\022\027: \004\206)Tj /Span<>> BDC ( )Tj EMC (\227 \033\031\f\025\020\t \032\027\b\032\027\024\024\022\t; \232\206)Tj /Span<>> BDC ( )Tj EMC (\227 \007\020\024\023\022\007\025\020\t \032\027\b\032\027\024\024\022\t\ ;)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.2777 56.0378 Tm (44)Tj ET endstream endobj 1520 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\t\013\n\255\n\026)11.1(\025\005\217 \r)10(\025\t\026\005\025\020\200\t\217\220 \026)11(\025\225\004\r \n\024\024\002\t\n\026)11(\004\026)11(\017 \224\005\n\022\020\004\225\004\t\n\n )]TJ 0 -1 TD [(\024\004\016)-10(\026\t\025\005\017\016\224\005\025\016)-10(\026\005\017\t\004\t\t\025\013)10(\025 \r)10(\025\020\025\005\004\r)-10(\026)11(\017\020\200\t\025\013)10.1(\025 \005\017\r\017 \016\022\024\n\r\005\025\016\017\026)11(\004\020\020\n\026\t\025\221 )]TJ T* [(\t\004\016)-10(\026)11(\017\255\n\020\200\t\025\016)-9.9(\026\200\206: \016\004\005\n\213\022\r)-9.9(\020\n\t\n\225\004\016\r\n\220 \016)-10(\020\002\225\017\004\b)]TJ 36.69 2 Td [(Ef)-31(f)-21(icacy of\022immunoth)11(er)21(apy in patients with locally adv)10(anced )]TJ 0.258 -1 Td [(color)31(ectal cancer 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23.244 10.96 Td (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\t\n \030\026\022\024\n \ \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \n\017)Tj 0 Tw (-)Tj T* (\022\030\024\f\026\021\036\035\017\021\027\024\005 \027\036\f\021\026\002\ \017\035\034\027\024\f\021\017.)Tj 0.463 Tw T* [(NICHE \(NCT03026140\), \023\017\035\024\021\027\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 II )]TJ 0.008 Tw T* (\235\026\t, \r\022\035\033\004\026\035\024 40 \023\026\006\017\036\027\021\ \024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\024\n \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.088 Tw T* (1\2263 \f\021\026\007\017\017, 21 \023\026\006\017\036\027\021 \017\n\036\ \035 dMMR-\024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (20)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.064 Tw T* (pMMR-\024\023\031\b\024\035\017 [8]. \200\f\036 \023\026\006\017\036\027\ \021\t \f)Tj /Span<>> BDC ( )Tj EMC (dMMR-\024\023\031\b\024\035\016\n\017 )Tj 0.1 Tw T* (\002\t\035\017 \023\030\024\035\036\004\036\027\t \024\007\027\024\005 \007\ \024\024\005 \017\023\017\035\017\n\031\n\026\002\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\n\016 )Tj 0.303 Tw 0 -1.218 TD [(\007\024\026\n\017 \027\017\r\024\035\031\n\026\002\026, \031\f\023\036\ \001\027\024 \023\036\030\036\027\036\f\035\017 )0.5(\023\035\026\027\024\r\t\036 )]TJ 0.347 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\020\035\017 \023\036\030\r\017\004\027\024\005 \022\024\ \027\036\004\027\024\005 \021\024\004\022\017: )Tj 0.363 Tw T* (20)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (dMMR-\024\023\031\b\024\035\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (21 \007\024\f\021\017\020\035\017 )Tj ET q 42.52 344.729 382.677 255.588 re W n q /GS0 gs 382.6771289 0 0 255.6782704 42.5196843 344.6392617 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.037 Tw 9 0 0 9 42.5197 333.9287 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(\202 \031\032\b\020\025\031\021 )0.6(\240\032\005\213\025\031\235 )0.5(\033\031\f\031\024\023\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 17.867 0 Td [(\021\025\r\023\032\022\021\027\025\025\013\026 )0.6(\n\031\025\023\032\020\024\023\022\032\031\021\020\025\022\027\026 )0.5(\(\033\031\032\023\020\f\017\025\020\t )0.5(\203\020\016\020\) )0.5(\033\020\006\022\027\025\023\020 )0.5(\2423. )0.5(\003. )0.5(\217\033\r)]TJ 0 Tw (-)Tj 0.07 Tw -17.867 -1.2 Td (\200\031\f\017 \033\027\007\027\025\031\007\025\031\b\031 \022\016\b\022\ \240\020 \023\031\f\024\023\031\235 \n\022\213\n\022 \211. \206\027\025\023\ \b\027\025\031\f\031\b\022\007\027\024\n\020\t \n\020\032\023\022\025\020\ \033\031\024\f\027 4 \n\r\032\024\031\021 \022\026\026\r\025\031\023\027\ \032\020\033\022\022 \025\022\021\031\f\r\026\020\240\031\026 )Tj 0 Tw 0 -1.2 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\022\033\022\f\022\026\r\026\020\240\031\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.061 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( CT scan of)Tj /Span<>> BDC ( )Tj EMC [(the abdominal cavity with intrav)13.1(enous contrast \(por)-39.9(tal phase\) in patient \2423. A. Obstructiv)13(e tumor of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0 Tw T* [(hepatic f)-21.9(le)-15(xure of)]TJ /Span<>> BDC ( )Tj EMC [(the colon. B. Af)-45.7(ter 4 courses of)]TJ /Span<>> BDC ( )Tj EMC [(immuno)13.3(therap)12(y with niv)13(olumab and ipilimumab)]TJ ET q 42.52 122.57 382.677 157.655 re W n q /GS0 gs 382.6771289 0 0 157.72827 42.5196805 122.4964751 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.039 Tw 9 0 0 9 42.5197 111.7701 Tm [(\022\t\217\210\b\002\220 )0.5(4.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( \202 )0.5(\031\032\b\020\025\031\021 )0.5(\b\032\r\030\025\031\235 \n\f\027\023\n\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 16.806 0 Td [(\021\025\r\023\032\022\021\027\025\025\013\026 )0.5(\n\031\025\023\032\020\024\023\022\032\031\021\020\025\022\027\026 \033\020\ \006\022\027\025\023\020 )0.5(\2423. \003. \207\031\025\013 \022\025\203\022\f\017\023\032\020\006\022\ \022 \021)]TJ /Span<>> BDC ( )Tj EMC 31.84 0 Td (\031\240\031)Tj 0 Tw (-)Tj -48.646 -1.2 Td [(\022\200 \f\027\b\n\022\200: \022\026\026\r\025\031\031\033\031\024\032\027\ \030\031\021\020\025\025\013\235 \033\025\027\021\026\031\025\022\023. \211\ . \206\020\016\032\027\213\027\025\022\027 \016\031\025 \022\025)0.6(\203\022\f\017\023\032\020\006\022\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\033\020\032\027\025\200\022\026\027 \f\027\b\n\022\200 \025\020)Tj /Span<>> BDC ( )Tj EMC (\203\031\025\027 \216\202\205)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.078 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( Chest CT scan of)Tj /Span<>> BDC ( )Tj EMC [(patient \2423. A. Immune-mediated pneumonitis. B. 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\020\024\007\026 )]TJ 0.078 Tw 0 -1.218 TD [(\023\030\017\027\026\022\024\r )0.6(\035\024\022\026\035\034\027\024\020\024 )0.5(\030\036\006\017\007\017\r\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.757 0 Td [(\r\021\024\030\017\004\027\024\020\024 )0.6(\023\024\030\026)]TJ 0 Tw (-)Tj 0.077 Tw -14.757 -1.218 Td [(\032\036\027\017\036 )0.5(\024\030\020\026\027\024\r \020\030\031\007\027\024\005 )0.5(\022\035\036\021\022\017 \035\017\002\024 \002\030\033\001\027\024\005 )0.5(\023\024\035\024)]TJ 0 Tw (-)Tj T* (\f\021\017 \027\036 \023\024\035\031\004\036\027\024.)Tj /T1_1 1 Tf 0 -2.436 TD (\027\200\007\220\001\005\007\n \235\003\007\005\007\006\n\220\235\004\217\ \004 \220\003\215\006\001\202 \2033)Tj /T1_0 1 Tf 0.041 Tw 0 -1.218 TD (\215\026\006\017\036\027\021 \204., 33 \035\036\021, \r)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\036 2024 \020. \024\021\n\036\021\017\035 \032\026\035\ \024\002\t )Tj 0.071 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\b\r\026\021\022\024\024\002\030\026\027\t\036 \002\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036, \031\f\017\035\036\027\017\036 \024\002\013\036\005\ )Tj -0.061 Tw T* (\f\035\026\002\024\f\021\017, \020\024\035\024\r\024\022\030\031\032\036\ \027\017\036, \002\035\036\007\027\t\036 \022\024\032\027\t\036 \023\024\ \022\030\024\r\t, )Tj -0.026 Tw T* (\024\002\f\035\036\007\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \026\027\036\n\017\017 \(Hb 78 \020/\035\)\ )Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.186 Tw T* [(\235\031\027\022\006\017\024\027\026\035\034\027\t\005 \f\021\026\021\031\ \f EC)13(OG 2. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\017 )Tj 0.256 Tw T* (\024\021 09.03.2024 \020. \r\t\016\r\035\036\027\026 \024\023\031\b\024\035\ \034, \024\002\021\031\030\017\030\031\033\013\026\016 )Tj 0.058 Tw 0 -1.218 TD (\023\030\024\f\r\036\021 \023\036\004\036\027\024\004\027\024\020\024 \017\ \020\017\002\026 \021\024\035\f\021\024\005 \022\017\001\022\017. \215\024\ )Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD (\027\t\n \025\221 \024\021 09.03.2024 \020. \024\021\n\036\004\026\036\021\ \f\016 \027\036\030\026\r\027\024\n\036\030\027\024\036 )Tj -0.027 Tw 0 -1.218 TD (\031\021\024\035\013\036\027\017\036 \f\021\036\027\022\017 \024\002\024\ \007\024\004\027\024\005 \021\024\035\f\021\024\005 \022\017\001\022\017\ \007\024)Tj /Span<>> BDC ( )Tj EMC (22)Tj /Span<>> BDC ( )Tj EMC (\n\n )Tj 0.026 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 7 \f\n. \206\017\f\021\024\035\024\ \020\017\004\036\f\022\024\036 \026\022\035\033\004\036\027\017\036 \024\ \021 )Tj 0.262 Tw T* [(18.03.2024 )0.5(\020.: )0.6(\026\007\036\027\024\022\026\030\006\017\027\024\n\026 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017 )0.5(G2. )]TJ 0.166 Tw T* (\211\f\021\026\027\024\r\035\036\027 \007\017\026\020\027\024: \217\026\ \022 \023\036\004\036\027\024\004\027\024\020\024 \017\020\017\002\026 \ \023\024\023\036)Tj 0 Tw (-)Tj T* (\030\036\004\027\024-\024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017 cT4aN0M0, II\202 \f\021\026\007\017\016.)Tj 0.006 Tc 0.09 Tw T* (\211\004\017\021\t\r\026\016 \024\002\255\201\n \024\023\031\b\024\035\036\ \r\024\020\024 \023\024\030\026\032\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\017\005)6( )]TJ 0.268 Tw T* [(\030\017\f\022 R1 \030\036\036\022\006\017\017, 07.05.2024 \020. \r\t\023\ \024\035\027\036\027\024 \204\206\230:)6( )]TJ 0.168 Tw T* (\r\t\016\r\035\036\027\026 \n\031\021\026\006\017\016 G12/13X \r\024 2 \220\ \022\024\027\036 \020\036\027\026 )Tj /T1_2 1 Tf -0.006 Tw [(KRA)50(S)]TJ /T1_0 1 Tf 0 Tc 0 Tw (, )Tj 0.006 Tc 0.165 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \230\206\216-\017\f\f\035\036\007\024\r\026\027\017\017 \024\ \021 08.05.2024 \020. \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.304 Tw T* (\035\017 \024\002\027\026\030\031\032\036\027\026 \023\024\021\036\030\016\ \220\022\f\023\030\036\f\f\017\017 MLH1 \017)Tj /Span<>> BDC ( )Tj EMC [(PMS2,)6( )]TJ 0.3 Tw T* (\004\021\024 \b\026\030\026\022\021\036\030\027\024 \007\035\016 \n\017\022\ \030\024\f\026\021\036\035\035\017\021\027\024\005 \027\036\f\021\026\002\ \017\035\034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.357 Tw T* (\027\024\f\021\017. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\001\036\027\017\033 \024\027\022\024\035\024\020\017\004\036\f\022\ \024\020\024 \022\024\027\f\017\035\017\031\n\026)6( )]TJ 0.097 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (15.05.2024 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC [(18.07.2024 \020. \023\030\024\r\036\007\036\027\024 4 \022\031\030\f\026\ )6( )]TJ 0.101 Tw T* [(\021\036\030\026\023\017\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 5.083 0 Td [(\f\b\036\n\036 )0.5(\017\023\017\035\017\n\031\n\026\002 )0.6(1 \n\020/\022\020)]TJ /Span<>> BDC ( )Tj EMC 11.671 0 Td (+)Tj /Span<>> BDC ( )Tj EMC 0.845 0 Td [(\027\017\r\024\035\031\n\026\002)6( )]TJ 0.046 Tw -17.599 -1.218 Td [(3 )0.5(\n\020/\022\020 )0.5(1 )0.5(\030\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.569 0 Td (3)Tj /Span<>> BDC ( )Tj EMC 0.79 0 Td [(\027\036\007\036\035\017. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 4.392 0 Td [(\n\036\032\006\017\022\035\024\r\024\n )0.5(\017\027\021\036\030\r\026\035\036)6( )]TJ 0.333 Tw -11.752 -1.218 Td [(\024\021\n\036\004\036\027\t )0.5(\027\036\f\021\026\002\017\035\034\027\024\f\021\034 )0.5(\f\021\031\035\026, \022\024\f\021\027\024-\f\031\f\021\026\r\027\024\005\ )6( )]TJ 0.098 Tw 23.244 35.316 Td (\002\024\035\036\r\024\005 \f\017\027\007\030\024\n, \026\f\021\036\027\017\ \016 1 \f\021\036\023\036\027\017, \f\027\017\032\036\027\017\036 \017\027\ )Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.077 Tw T* [(\021\036\027\f\017\r\027\024\f\021\017 \002\024\035\036\r\024\020\024 \f\ \017\027\007\030\024\n\026, \031\035\031\004\001\036\027\017\036 \024\002\ \013\036\020\024)6( )]TJ -0.006 Tw T* (\f\026\n\024\004\031\r\f\021\r\017\016.)Tj 0 Tc 0.075 Tw T* (\215\024 \007\026\027\027\t\n \025\221 \024\021 21.07.2024 \020. \024\021\ \n\036\004\026\036\021\f\016 \031\n\036\027\034\001\036)Tj 0 Tw (-)Tj -0.02 Tw T* [(\027\017\036 )0.5(\021\024\035\013\017\027\t )0.6(\024\023\031\b\024\035\036\r\t\b )0.5(\017\n\036\027\036\027\017\005 )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj -0.007 Tw T* (\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\036\n \r\t\030\026\032\036\027\027\024\ \f\021\017 \017\027\235\017\035\034\021\030\026\006\017\017 \023\030\017\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\035\036\032\026\013\036\005 \022\035\036\021\004\026\021\022\017.)Tj -0.054 Tw 0 -1.218 TD (\200 \026\r\020\031\f\021\036 2024 \020. \023\026\006\017\036\027\021 \024\ \021\n\036\021\017\035 \023\024\f\021\036\023\036\027\027\024\036 \027\026\ \030\026\f)Tj 0 Tw (-)Tj 0.081 Tw T* [(\021\026\027\017\036 )0.5(\024\007\t\001\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.06 0 Td [(\023\030\017\r\t\004\027\024\005 )0.5(\235\017\017\004\036\f\022\024\005 )0.6(\027\026\020\030\031\022\036, )]TJ 0.221 Tw -8.06 -1.218 Td (\f\031\b\024\005 \022\026\001\036\035\034. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\025\221 \r\t\016\r\035\036\027\t \017\027\021\036\030\f\021\017\006\017\ \026\035\034\027\024-)Tj 0.116 Tw T* [(\024\004\026\020\024\r\t\036 )0.5(\017\n\036\027\036\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 9.841 0 Td [(\035\036\020\022\017\b, )0.5(\f\024\024\021\r\036\021\f\021\r\031\033\013\017\036 )0.6(\017\n)]TJ 0 Tw (-)Tj 0.234 Tw -9.841 -1.218 Td (\n\031\027\024\024\023\024\f\030\036\007\024\r\026\027\027\024\005 \f\026\ \030\022\024\017\007\024\024\023\024\007\024\002\027\024\005 \030\036\026\ \022\006\017\017 )Tj 0.35 Tw 0 -1.218 TD [(\(\023\027\036\r\n\024\027\017\021 )0.6(2 )0.5(\f\021\036\023\036\027\017\). )0.6(\212\035\016 )0.5(\022\024\030\030\036\022\006\017\017 )0.6(\017\n\n\031\027\024\024)]TJ 0 Tw (-)Tj 0.299 Tw 0 -1.218 TD [(\023\024\f\030\036\007\024\r\026\027\027\024\020\024 )0.5(\024\f\035\024\032\027\036\027\017\016 )0.6(\023\024\035\031\004\026\035 )0.6(\023\030\036\007\027\017\024\035\024\027 )]TJ 0.133 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\036 1)Tj /Span<>> BDC ( )Tj EMC (\n\020/\022\020 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 3 \007\027\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n )Tj -0.068 Tw T* (\f\027\017\032\036\027\017\036\n \007\024\017\030\024\r\022\017 \022\026\ \032\007\031\033 \027\036\007\036\035\033, \r\023\035\024\021\034 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\035)Tj 0 Tw (-)Tj 0.059 Tw T* (\027\024\005 \024\021\n\036\027\t. \203\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\n \025\221 \024\021 04.10.2024)Tj /Span<>> BDC ( )Tj EMC (\020. \030\036)Tj 0 Tw (-)Tj 0.334 Tw T* (\020\030\036\f\f \n\036\035\022\024\024\004\026\020\024\r\024\005 \007\017\ \f\f\036\n\017\027\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\201\020\022\017\b, \024\027 )Tj 0 Tw T* (\022\024\027\f\024\035\017\007\026\006\017\017.)Tj 0.085 Tw T* (\200 \023\024\f\035\036\007\031\033\013\036\n 25.10.2024 \020. \023\030\024\ \r\036\007\036\027\024 \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.254 Tw T* (\f\022\024\036 \035\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \035\026\023\026\030\024\f\022\024\023\017\004\036\ \f\022\024\005 \023\030\026\r\024)Tj 0 Tw (-)Tj 0.78 Tw T* [(\f\021\024\030\024\027\027\036\005 )0.6(\020\036\n\017\022\024\035\220\022\021\024\n\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 14.554 0 Td (\035\017\n\235\024\007\017\f\f\036\022\006\017\036\005 )Tj 0.305 Tw -14.554 -1.218 Td (D2. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n \017\ \f\f\035\036\007\024\r\026\027\017\017 \024\023\036)Tj 0 Tw (-)Tj 0.297 Tw T* (\030\026\006\017\024\027\027\024\020\024 \023\030\036\023\026\030\026\021\ \026 \024\002\027\026\030\031\032\036\027 \023\024\035\027\t\005 \030\036\ \020\030\036\f\f )Tj 0.21 Tw T* (\024\023\031\b\024\035\017)Tj /Span<>> BDC ( )Tj EMC (\227 TRG1 \023\024)Tj /Span<>> BDC ( )Tj EMC [(Mand)42(ar)-24(d. \200)]TJ /Span<>> BDC ( )Tj EMC (16 \017\f\f\035\036\007\024\r\026\027\027\t\b )Tj 0.342 Tw T* (\035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\026\b \030\036\020\ \017\024\027\026\030\027\024\005 \032\017\030\024\r\024\005 \022\035\036\ \021)Tj 0 Tw (-)Tj 0.363 Tw T* (\004\026\021\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\026\022\021\017\r\027\026\016 \023\026\030\026\022\024\030\ \021\017\022\026\035\034\027\026\016 \020\017\023\036\030\023\035\026)Tj 0 Tw (-)Tj 0.076 Tw T* [(\017\016, )0.5(\024\004\026\020\024\r\t\005 \235\017\002\030\024 )0.5(\f\021\030\024\n\t, )0.5(\024\023\031\b\024\035\036\r\024\020\024 \030\024\f\021\026 )0.5(\027\036 )]TJ 0 Tw T* (\r\t\016\r\035\036\027\024.)Tj T* (\215\026\006\017\036\027\021\031 \030\036\022\024\n\036\027\007\024\r\026\ \027 \007\017\027\026\n\017\004\036\f\022\017\005 \022\024\027\021\030\024\ \035\034.)Tj ET q /GS0 gs 368.4000092 0 0 213.1199952 70.8661499 133.3700866 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.1 Tw 9 0 0 9 70.8661 122.5701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \215\206 \031\032\b\020\025\031\021 \026\020\f\031\b\031 \023\020\016\020\ \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\r\023\032\022\021\027\025\025\013\026 \n\031\025\023\032\020\024\ \023\022\032\031\021\020\025\022\027\026 \033\020\006\022\027\025\023\020\ \2422. \003. \217\033\r\200\031\f\027\021\031\027 \031\240\032\020\016\031\ \021\020\025\022\027 )Tj 0.04 Tw 0 -1.2 TD [(\024\032\027\030\025\027- )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 4.099 0 Td [(\025\022\255\025\027\020\026\033\r\f\t\032\025\031\b\031 )0.6(\031\023\030\027\f\020 )0.5(\033\032\t\026\031\235 )0.6(\n\022\213\n\022. )0.5(\211. )0.5(\202\031\025\023\032\031\f\017 )0.6(\033\031\024\f\027 )0.5(\023\027\032\020\033\022\022 )0.5(\002\202\002: )0.6(\r\007\020\024\023\n\031\021 )0.5(\032\027\024\023\032\022\n\006\022\022 )0.5(\030\022\203\203\r\016\022\022 )]TJ 0 Tw -4.099 -1.2 Td [(\022\f\022 \033\020\023\031\f\031\b\022\007\027\024\n\031\b\031 \025\020\ \n\031\033\f\027\025\022\t \n\031\025\023\032\020\024\023\025\031\b\031 \ \033\032\027\033\020\032\020\023\020 \025\027 \021\013\t\021\f\027)0.6(\025\031)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.017 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( P)15(elvic MRI, patient \2422. A. T)57(umor for)-13.9(mation of)]TJ /Span<>> BDC ( )Tj EMC [(the middle and low)12(er am)16(pullar)-43(y par)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(the rectum. B. N)17(o evidence of)]TJ /Span<>> BDC ( )Tj EMC (dif)Tj 0 Tw (-)Tj T* [(fusion restr)-36.9(iction or abnor)-13.8(mal enhancement af)-45.9(ter ICI treatment)]TJ ET 1 0.68 0 0.12 k /GS0 gs 70.866 133.37 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 80.4156 142.1385 Tm (A)Tj ET 1 0.68 0 0.12 k 257.106 133.37 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 266.655 142.1385 Tm (B)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1902 56.0378 Tm (42)Tj ET endstream endobj 1519 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;0""  !1AQ"2aq#5Br$3RS %&'()*46789:CDEFGHIJTUVWXYZbcdefghijstuvwxyz!1AQaq"2BRb#3 $%&'()*456789:CDEFGHIJSTUVWXYZcdefghijrstuvwxyz?M4.JM2+^_zҽE'VL4UUkfl<$ _j=eW1xpY2S$Y% 鼩_[9;輀g Fu,ø>* ÇU;/GO [&IiZ뒽^]+i`.!sN:e+M+!j0;TVm&_Zh  4(iyִMv *c0  8 BA2ҐB\̯F7ShZOZg.A- G75]:XHZ$ܪɒ$!l&5qXES.ʙ4@Ȃ>8w_eB߾Sڵ^C,`9 p.jNf\/s\n5eTY雋N.Q"Yڽ$Q#W:a^E#ٱXΝ: /}BӧABM30(âxKXp <߯~ևTmD*,jnfNIr4EI3t6)U0S7 ]}%XZ_@,4u9H!cH jVM2S5iҰ50jؼf^Fa_;@tyI._?q JJ$8y,\{V;‰p|PQ|Bx"8'VfW.%WEyҹK+TJGS_a-w)YUx-)@M5M+`A"]PR9 Sq RV)U i!iaQ-/XIc1.2*/ԩ`=X+7t^mNfԘM5h--uկj xcLv_Rڄ\-ff_H!vGo'ўPj|2x1NI\l{TUq0R76]# kWSG*X87xNypfsڱZH,*:Hx$:^Reo5õz}{O~kHy(~<\ΐP~#ېH_}䟉wڿA_}䟉wڷ?=d^'W~7n>yg.a_k +e^I8Ԯ{/ dJObT \k!}/uw|FlWOn̪VXʴ_S%WB_+07Px i^2Bސ/_^)ˢeM4 SAZ'.|Ky[K,tF}3NNsM?@\EpDDS:/[0tZ2t o QKK L9YUEX6' H"Mw AY/ V|^&-:32kiJ'[ƹqOzj<5=kڬxy,s\זu@BUsB$2eoOiGL /N9ċlQ0%NfiHCINMB+Ys5E`ߪh?uTV)㤪}"jv] o+8|vf3eR~@8'}[^M蹥})}dyfaw+]>N!PZYtQ(Mȗ?,t9XھGM fԎjBR$ᯔ!z@xeW!y\s:\UA_GV(uƥls|DC8X$ڦ-V͍ -䲂 p$U/-6^na _Th؈%j$U_?ʆp_p`eZDS$eWS*w2yHTe`8rqf i ^\Eդ.[00JÕ?|<}*y{<79l wglo X/8$'ΜR,]m p2]\BS1:[`8cΦlOr7:,=h|&,R9NQfJTvaӣ!{%Fԝi{&jE}2ZA_ 8v}돱Be7S/KM279OVF  T*;>Nhm g3$}쩼 +-6ީ.'p\Gh]0q|~Dvv{Xz&eHC .e;Hflm/J`X5V9 Jn ~6!jڦ o3: (Ht'ejs(@ ^hV6xnj/ Qʋm_-JSWH_bKEqAv _:j0w] {c45β)@8Z.S< WNu]Wx. 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O=CV#)MZ1G(LtHV°W% $)ٰ} hup?go¼?go¼%Z:J)d>mt_qFUT\D&%Q1=讔)W%fEe,o pNџb|``ބ! q+R,:S=u=ZE{k<Eꆅn-ſ:F#jT@aWFWTSR(*WdjuҰG6#YZJ~ .Q!A7UmjPG-JAM-^Vmr;deRm -\b/s-fK/Uve7l[/VG+YئQpxAkxX&Rv_k3TD |gi4S-K 7$uA0&g e:#xZ*9*6g j< u3{@Ӵk8y:[IvzO4- 4 /peÑ79aY׌ u7ru>u)](_=O$pՆ!av~ c;D.73$8y[cd ϒajXxL oeKB—"J`Zn6 S"5DjT&DQTt^V8\\p٤[:@RZVM:M|P 6]C#-Kpih!iWVVTZFeHqp*$&[YQIH\6IPux!K̺;7Ϳ#DU2 /౥ܲ\ۇhd+Ok[qRۙ&wu3 w klT(ly;n"ZmXoceI&\/&Sv+5y+oHMn-p48&Ψ<9LU 5X\DIZм-j`z'mpW0WW0$R B79 r3rB^qt 9Uav8Is F49FK(m k 1+OK)Jdf]Y*KPByZ){n OzUm3{VqEV35L/6&W95Xc2 ) ucHK[oj<o[α5*mG4**ue Z{ 4봖XW :$p⪾Y{jc %HkmV7\įW:,.̀&s:E J5|O(\0蠢0*%@ `YS;įS UO+IK rQU)BW@aƄܓʥvRy]/-qQg:Ԯ.Gk5&b 榅/ ѧHuM]8ʢyrrwJI^xjgCpZY^ΑpbG߸ЈYPQ4 o+Z |ҠHk⼜=|{K~_S0.VHчCgge/=/j7T,.IJ%ˉuĵG/Orz 9V Zk:6M&m;%Su6s/{ 9ڼz^{;gIiT MR[ʲ[(ؙ[pMwwR ˯2v8 \L=Ip[uE.ctmfHE@ /+xW5PƳ9H+åM>0_J#Oͅlp& z~3"BN;4YDBN:T*Bdy(v'A D@!bU7d JtYT3,ƑqkN.L\6 *ֶ`jH~RtjtٴC.Vh.3+:_8ۜѴmn./:tm(V)RΝ: ) PBkN!MLӠ&N:M@ endstream endobj 1527 0 obj <>stream endstream endobj 1516 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\t\013\n\255\n\026)11.1(\025\005\217 \r)10(\025\t\026\005\025\020\200\t\217\220 \026)11(\025\225\004\r \n\024\024\002\t\n\026)11(\004\026)11(\017 \224\005\n\022\020\004\225\004\t\n\n )]TJ 0 -1 TD [(\024\004\016)-10(\026\t\025\005\017\016\224\005\025\016)-10(\026\005\017\t\004\t\t\025\013)10(\025 \r)10(\025\020\025\005\004\r)-10(\026)11(\017\020\200\t\025\013)10.1(\025 \005\017\r\017 \016\022\024\n\r\005\025\016\017\026)11(\004\020\020\n\026\t\025\221 )]TJ T* [(\t\004\016)-10(\026)11(\017\255\n\020\200\t\025\016)-9.9(\026\200\206: \016\004\005\n\213\022\r)-9.9(\020\n\t\n\225\004\016\r\n\220 \016)-10(\020\002\225\017\004\b)]TJ 36.69 2 Td [(Ef)-31(f)-21(icacy of\022immunoth)11(er)21(apy in patients with locally adv)10(anced )]TJ 0.258 -1 Td [(color)31(ectal cancer and micr)20(osatellite instabilit)-20(y: a\022case series)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.62 Tw 10 0 0 10 42.5197 724.8299 Tm (\017\027\r\026\017\017 \023\030\036\f\026\022\030\026\035\034\027\024\005\ \235\026\f\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\022\024\f\021\027\017\006\t )Tj 0.122 Tw 0 -1.218 TD (\022\030\036\f\021\006\026 \024\021 \031\030\024\r\027\016 L3 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\036, \002\036 \023\030\017\027\026\022\024\r \030\036\020\ \017\024)Tj 0 Tw (-)Tj 0.321 Tw T* [(\027\026\030\027\024\005 )0.5(\035\017\n\235\026\007\036\027\024\023\026\021\017\017. )0.5(\211\004\017\021\t\r\026\016 )0.6(\017\027\r\026\035\017\007\017\017\030\031)]TJ 0 Tw (-)Tj 0.282 Tw T* [(\033\013\017\005 \b\026\030\026\022\021\036\030 \r\024\n\024\032\027\024\ \005 )0.5(\030\026\007\017\022\026\035\034\027\024\005 \024\023\036\030\026\006\017\ \017 )]TJ -0.014 Tw T* [(\(\002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\026\016\ )0.6(\220\022\f\021\017\030\023\026\006\017\016 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )]TJ 0.049 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\036\005 \022\030\036\f\021\006\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 L1-L2\), \002\t\035\024 \023\030\017\027\016\021\024\ )Tj 0.033 Tw 0 -1.218 TD (\030\036\001\036\027\017\036 \023\030\024\r\036\f\021\017 \n\024\035\036\ \022\031\035\016\030\027\024-\020\036\027\036\021\017\004\036\f\022\024\036\ \017\f\f\035\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\007\024\r\026\027\017\036 \(\204\206\230\).)Tj 0.303 Tw T* (\215\030\017 \017\f\f\035\036\007\024\r\026\027\017\017 \024\021 23.03.2\ 023 \020. \r\t\016\r\035\036\027\026 \n\031)Tj 0 Tw (-)Tj 0.088 Tw T* (\021\026\006\017\016 p.G13D \r)Tj /Span<>> BDC ( )Tj EMC (13 \022\024\007\024\027\036 2 \220\022\024\027\026 \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw [(KRA)50(S)]TJ /T1_1 1 Tf 0.088 Tw (, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj 0.197 Tw T* (\230\206\216-\017\f\f\035\036\007\024\r\026\027\017\017 \024\021 19.04.2\ 023 \020. \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\017 \023\030\016)Tj 0 Tw (-)Tj 0.231 Tw T* (\n\024\005 \022\017\001\022\017 \024\002\027\026\030\031\032\036\027\026\ \030\036\007\022\026\016 \017\024\035\017\030\024\r\026\027\027\026\016\ \023\024)Tj 0 Tw (-)Tj 0.312 Tw 0 -1.218 TD (\021\036\030\016 \220\022\f\023\030\036\f\f\017\017 \002\036\035\022\026\ \030\036\023\026\030\026\006\017\017 \212\203\025 )Tj /T1_2 1 Tf 0 Tw (MSH6)Tj /T1_1 1 Tf 0.312 Tw (, \004\021\024 )Tj 0.289 Tw 0 -1.218 TD [(\b\026\030\026\022\021\036\030\027\024 )0.6(\007\035\016 )0.5(\026\030\024\007\t\001\036\r\t\b )0.6(\n\031\021\026\006\017\005 )0.5(\020\036\027\026 )]TJ /T1_2 1 Tf 0 Tw 19.63 0 Td (MSH6)Tj /T1_1 1 Tf (. )Tj 0.15 Tw -19.63 -1.218 Td (\200\t\023\024\035\027\036\027\024 \007\026\035\034\027\036\005\001\036\036\ \204\206\230, \017\f\f\035\036\007\024\r\026\027\024 5 \n\017\022\030\024\ )Tj 0 Tw (-)Tj 0.144 Tw 0 -1.218 TD [(\f\026\021\036\035\035\017\021\027\t\b \035\024\022\031\f\024\r: NR-21, \ BA)15.1(T-26, BA)15(T-25, NR-24, )]TJ 0.377 Tw T* (NR-27. \210\002\027\026\030\031\032\036\027\t \026\035\035\036\035\034\027\ \t\036 \r\026\030\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\031)Tj 0 Tw (-)Tj 0.191 Tw T* (\f\026\b NR-21 \017)Tj /Span<>> BDC ( )Tj EMC (NR-27, \004\021\024 \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \022\035\017\027\017\004\036\f\022\024\005 \022\026\ \030)Tj 0 Tw (-)Tj 0.509 Tw T* (\021\017\027\t \026\002\024\035\036\r\026\027\017\016 \023\024\r\024\035\ \017\035\024 \023\024\007\021\r\036\030\007\017\021\034 \027\026\035\017\ )Tj 0 Tw (-)Tj 0.238 Tw T* (\004\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \n\017\022\030\024\f\026\021\036\035\035\ \017\021\027\024\005 \027\036\f\021\026\002\017\035\034\027\024\f\021\017\ . )Tj 0.447 Tw T* [(\215\024\035\027\024\020\036\027\024\n\027\024\036 )0.5(\f\036\022\r\036\027\017\030\024\r\026\027\017\036 \024\021 )0.5(05.05.2023)]TJ /Span<>> BDC ( )Tj EMC (\020. )Tj 0.072 Tw T* (\023\024\007\021\r\036\030\007\017\035\024 \027\026\035\017\004\017\036 \ \r\036\030\024\016\021\027\024 \023\026\021\024\020\036\027\027\024\020\024\ \r\026\030\017\026\027)Tj 0 Tw (-)Tj 0.031 Tw T* (\021\026 \027\031\022\035\036\024\021\017\007\027\024\005 \023\024\f\035\ \036\007\024\r\026\021\036\035\034\027\024\f\021\017 \020\036\027\026 )Tj /T1_2 1 Tf 0 Tw (\215SH6)Tj /T1_1 1 Tf 0.031 Tw ( ch3: )Tj 0 Tw T* [(g47805028delGA)16(GA)16.1(G)-12(TTTTTT.)]TJ 0.041 Tw T* (\211\004\017\021\t\r\026\016 \007\026\027\027\t\036 \204\206\230 \017)Tj /Span<>> BDC ( )Tj EMC (\230\206\216 \017\f\f\035\036\007\024\r\026\027\017\005, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\001\036)Tj 0 Tw (-)Tj 0.32 Tw T* (\027\017\033 \n\036\032\007\017\f\006\017\023\035\017\027\026\030\027\024\ \020\024 \022\024\027\f\017\035\017\031\n\026 \030\036\022\024\n\036\027\ \007\024)Tj 0 Tw (-)Tj 0.382 Tw T* [(\r\026\027\024 )0.5(\023\030\024\r\036\007\036\027\017\036 )0.5(\027\036\024\026\007\255\033\r\026\027\021\027\024\005 )0.6(\017\n\n\031\027\024\021\036\030\026\023\017\017 )]TJ 0.173 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.407 0 Td [(\f\b\036\n\036 )0.5(\017\023\017\035\017\n\031\n\026\002 )0.5(1 \n\020/\022\020)]TJ /Span<>> BDC ( )Tj EMC 11.809 0 Td (+)Tj /Span<>> BDC ( )Tj EMC 0.906 0 Td [(\027\017\r\024\035\031\n\026\002 )0.5(3)]TJ /Span<>> BDC ( )Tj EMC (\n\020/\022\020 )Tj 0.009 Tw -14.121 -1.218 Td (4)Tj /Span<>> BDC ( )Tj EMC (\006\017\022\035\026 1 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (3 \027\036\007\036\035\017, \007\026\035\036\036 \n\024\027\024\021\036\030\ \026\023\017\016 \027\017\r\024\035\031)Tj 0 Tw (-)Tj 0.007 Tw T* (\n\026\002\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\036 240 \n\020 1 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC [(2 \027\036\007\036\035\017. )0.5(\222)]TJ /Span<>> BDC ( )Tj EMC (16.05.2023)Tj /Span<>> BDC ( )Tj EMC (\020. )Tj -0.001 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (18.07.2023 \020. \023\030\024\r\036\007\036\027\024 4 \022\031\030\f\026\ \035\036\004\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\b\036\n\036 )Tj 0.117 Tw T* (\017\023\017\035\017\n\031\n\026\002 1 \n\020/\022\020)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\027\017\r\024\035\031\n\026\002 3)Tj /Span<>> BDC ( )Tj EMC (\n\020/\022\020. \211\004\017\021\t\r\026\016 )Tj 0.721 Tw T* [(\031\n\036\027\034\001\036\027\017\036 \023\030\024\021\016\032\036\027\027\ \024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\026 \024\023\031\b\024\035\017 )Tj 0.54 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\027\021\030\024\035\034\027\024\020\024 \024\ \002\f\035\036\007\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\033\035\036 )Tj 0.255 Tw T* [(2023 \020., )0.5(\035\036\004\036\027\017\036 )0.5(\023\030\024\007\024\035\032\036\027\024 \023\024)]TJ /Span<>> BDC ( )Tj EMC 14.774 0 Td [(\f\b\036\n\036 )0.5(\027\017\r\024\035\031\n\026\002 )]TJ 0.06 Tw -14.774 -1.218 Td (240 \n\020 \r/\r \022\026\023\036\035\034\027\024 1 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (14 \007\027\036\005, \f)Tj /Span<>> BDC ( )Tj EMC (09.08.2023 \020. )Tj 0.04 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.273 0 Td [(22.05.2024 )0.5(\020. )0.6(\(24 )0.5(\022\031\030\f\026\). )0.5(\230\n\n\031\027\024\024\023\024\f\030\036\007\024\r\026\027\027\t\b )]TJ 0.176 Tw -1.273 -1.218 Td (\027\036\032\036\035\026\021\036\035\034\027\t\b \016\r\035\036\027\017\005\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\n \023\030\024\021\016\032\036\027\017\017 \022\031\030\f\026 )Tj 0 Tw T* (\035\036\004\036\027\017\016 \027\036 \024\021\n\036\004\026\035\024\f\034\ .)Tj 0.105 Tw T* (\204\217\221 \210\204\221 \f)Tj /Span<>> BDC ( )Tj EMC (\r/\r \022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n \024\ \021 16.04.2024)Tj /Span<>> BDC ( )Tj EMC (\020.: )Tj 0.572 Tw T* [(\022\026\030\021\017\027\026 \023\024\f\021\035\031\004\036\r\t\b )0.5(\017\n\036\027\036\027\017\005 \023\030\016\n\024\005 )0.5(\022\017\001\022\017, )]TJ 0.27 Tw T* (\031\002\036\007\017\021\036\035\034\027\t\b \204\217-\007\026\027\027\t\ \b \026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \031\004\026\f\021\022\024\r \030\036)Tj 0 Tw (-)Tj 0.233 Tw T* [(\f\021\030\017\022\006\017\017 \007\017\235\235\031\017\017 )0.5(\017\035\017 \023\026\021\024\035\024\020\017\004\036\f\022\024\020\024 \ \027\026\022\024\023\035\036)]TJ 0 Tw (-)Tj 0.449 Tw T* (\027\017\016 \022\024\027\021\030\026\f\021\027\024\020\024 \023\030\036\ \023\026\030\026\021\026 \027\036 \023\024\035\031\004\036\027\024, \030\ \026\027\036\036 )Tj 0.396 Tw T* [(\024\023\030\036\007\036\035\016\r\001\017\036\f\016 )0.5(\021\026\024\r\t\036 \035\017\n\235\026\021\017\004\036\f\022\017\036 \031\ \035\t \027\036 )]TJ 0 Tw T* (\r\017\031\026\035\017\017\030\031\033\021\f\016.)Tj 0.071 Tw T* (\215\024 \007\026\027\027\t\n \022\024\035\024\027\024\f\022\024\023\017\ \017 \024\021 17.06.2024 \020.: \r)Tj /Span<>> BDC ( )Tj EMC (\026\n\023\031\035\036 )Tj 0.116 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017 7 \f\n \024\021 \026\027\031\f\026 \ \024\021\n\036\004\036)Tj 0 Tw (-)Tj 0.104 Tw T* (\027\024 \006\017\030\022\031\035\016\030\027\024\036 \030\031\002\006\024\ \r\024\036 \f\031\032\036\027\017\036 \023\030\024\f\r\036\021\026 \022\017\ \001\022\017. )Tj 0.239 Tw T* (\003\026\022\035\033\004\036\027\017\036: \023\024\035\027\026\016 \030\036\ \024\030\002\006\017\016 \024\023\031\b\024\035\017, \030\031\002\006\024\ \r\t\005 )Tj -0.009 Tw T* (\f\021\036\027\024 \023\030\016\n\024\005 \022\017\001\022\017, \023\024\ \f\021\035\031\004\036\r\024\005 \023\030\024\022\021\024\f\017\020\n\024\ \017\007\017\021.)Tj 0.026 Tw T* (\211\004\017\021\t\r\026\016 \023\024\035\027\t\005 \022\035\017\027\017\ \004\036\f\022\017\005 \024\021\r\036\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\027)Tj 0 Tw (-)Tj -0.021 Tw T* (\021\030\024\035\034\027\024\020\024 \024\002\f\035\036\007\024\r\026\027\ \017\016, \023\026\006\017\036\027\021\031 \030\036\022\024\n\036\027\007\ \024\r\026\027 \007\017)Tj 0 Tw (-)Tj T* (\027\026\n\017\004\036\f\022\017\005 \022\024\027\021\030\024\035\034.)Tj ET q 274.961 241.37 217.195 496.063 re W n q /GS0 gs 217.1951428 0 0 496.0689068 274.9606323 241.3642597 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.032 Tw 9 0 0 9 274.9606 230.5701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \202 \031\032\b\020\025\031\021 \240\032\005\213\025\031\235 \033\031\f\ \031\024\023\022 \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\r\023\032\022\021\027\025\025\013\026 )Tj 0.203 Tw 0 -1.2 TD [(\n\031\025\023\032\020\024\023\022\032\031\021\020\025\022\027\026 )0.6(\(\033\031\032\023\020\f\017\025\020\t )0.5(\203\020\016\020\) )0.5(\033\020\006\022\027\025\023\n\022 )0.5(\2421. )]TJ 0.027 Tw T* (\003.)Tj /Span<>> BDC ( )Tj EMC (\003\n\024\022\020\f\017\025\031\027 \022\016\031\240\032\020\255\027\025\ \022\027: \033\032\031\023\t\255\027\025\025\031\027 \024\023\027\025\031\ \016\022\032\r\005\212\027\027 )Tj 0.091 Tw T* (\033\032\031\024\021\027\023 \031\240\032\020\016\031\021\020\025\022\027\ \033\027\007\027\025\031\007\025\031\b\031 \022\016\b\022\240\020 \031\240\ \031\030\031\007\025\031\235 \n\022\213)Tj 0 Tw (-)Tj 0.081 Tw T* (\n\022. \221.)Tj /Span<>> BDC ( )Tj EMC (\214\032\031\025\023\020\f\017\025\031\027 \022\016\031\240\032\020\255\027\ \025\022\027: \031\240\f\020\024\023\017 \022\025\021\020\016\022\022 \021\ )Tj /Span<>> BDC ( )Tj EMC (\220\004\202 )Tj 0.059 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC [(\021\025\r\023\032\022\033\032\031\024\021\027\023\025\013\026 \031\033\r\ \200\031\f\027\021\013\026 \n\031\026\033\031\025\027\025\023\031\026. )0.5(\205. \205\031\024\023\031)]TJ 0 Tw (-)Tj 0.065 Tw T* (\t\025\022\027 \033\031\024\f\027 24 \n\r\032\024\031\021 \023\027\032\020\ \033\022\022 \033\027\026\240\032\031\f\022\016\r\026\020\240\031\026: \025\ \027\016\025\020\007\022)Tj 0 Tw (-)Tj 0.213 Tw T* (\023\027\f\017\025\020\t \022\025\203\022\f\017\023\032\020\006\022\t \023\ \n\020\025\027\235 \021)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\027\n\006\022\022 \033\027\007\027\025\031\007\025\031\b\031\ )Tj 0 Tw T* (\022\016\b\022\240\020 \031\240\031\030\031\007\025\031\235 \n\022\213\n\ \022 \022)Tj /Span<>> BDC ( )Tj EMC (\025\022\024\200\031\030\t\212\027\235 \021\027\023\021\022 \220\004\202\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.005 Tc 0.185 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( A)12(bdominal CT scan \(por)-40(tal phase\) of)]TJ /Span<>> BDC ( )Tj EMC [(patient \2421.)-5( )]TJ 0.017 Tw T* (A.)Tj /Span<>> BDC ( )Tj EMC [(Axial imag)12(e: an)]TJ /Span<>> BDC ( )Tj EMC [(e)-15(xtensiv)13(e tumor of)]TJ /Span<>> BDC ( )Tj EMC [(the hepatic f)-22(le)-15(xure of)]TJ /Span<>> BDC ( )Tj EMC [(the)-5( )]TJ -0.038 Tw T* [(colon. B. F)27(rontal imag)12(e: in)11(v)16(asion into the)]TJ /Span<>> BDC ( )Tj EMC (duodenum with the)Tj /Span<>> BDC ( )Tj EMC (in)Tj 0 Tc 0 Tw (-)Tj -0.005 Tc 0.074 Tw T* [(traluminal tumor com)16(ponent \(mark)17(ed with an)]TJ /Span<>> BDC ( )Tj EMC [(ar)-15.9(row\). C. Af)-46(ter)-5( )]TJ 0.05 Tw T* [(ICI treatment: minimal tissue scar)-16(r)-37(ing around the)]TJ /Span<>> BDC ( )Tj EMC [(hepatic f)-22(le)-15(x)]TJ 0 Tc 0 Tw (-)Tj -0.005 Tc T* (ure of)Tj /Span<>> BDC ( )Tj EMC (the colon and the)Tj /Span<>> BDC ( )Tj EMC (descending branch of)Tj /Span<>> BDC ( )Tj EMC (the duodenum)Tj ET 1 0.68 0 0.12 k /GS0 gs 274.961 569.201 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 0 Tc 11 0 0 11 284.5101 577.9692 Tm (A)Tj ET 1 0.68 0 0.12 k 274.961 241.345 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 284.9996 250.1133 Tm (C)Tj ET 1 0.68 0 0.12 k 274.961 412.958 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 284.5101 421.7263 Tm (B)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0771 56.0378 Tm (41)Tj ET endstream endobj 1517 0 obj <>stream Adobed    ' "'''''",////,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;; ""   {!1"AQqa24BTUb3 #$%&'()*56789:CDEFGHIJRSVWXYZcdefghijrstuvwxyzx!1AQaq"2BR#3%4br $&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz? !Ew! 8!N!!BBpB7EN@:Ffc]S4n 8BqBB!BaB!B8BL%/TINw`,58ֻ&X\ra|cs0m흷i纩kg䃢[&uZ(1F |U5^W$Vh#F$5r^V?jv+Vpܤl'İNĕqE**10ˣgu0z/|4jmH/&0kBT'ty2g.{7g݋h 'CenIZGz#ǽ2W$v&ֽӔݒTeh`Q) \B.ZWSkSA C{2YCfY>Z)+Ǹ!p6cB;_2PC &opPv$7MK:V/W$IPb%|>5m-{G5r 5.֌V=QzF5̬u/fۻF`ZuԌP:ƴNn۶ g2% 8Ԫ%;q#Қ턀ͺWk76&Tq,ךv7T+n3}luW8=bj *Gp*#|\6]8\l? *Qxn ikNIXN7Wث %F!w *<hl{wTB `=_a;vB͊pzܐN/sHm7߇=W;l,iQŠj1 IJ;]ڴ*N龫?k^ !zD^bu=sTխ@ ?ޘA!u]Og:v͗f}fC8Z! !!! 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\030\026\n\036\030\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 )Tj 0 Tw T* (\024\022\024\035\024 9 \n\n, \r\t\f\024\021\024\005 \024\022\024\035\024\ 2 \n\n.)Tj 0.008 Tc 0.784 Tw T* [(\215\024 \030\036\001\036\027\017\033 \024\027\022\024\035\024\020\017\004\ \036\f\022\024\020\024 \022\024\027\f\017\035\017\031\n\026 \024\021)8( )]TJ 0.212 Tw T* [(05.12.2022 \020., \031\004\017\021\t\r\026\016 \r\t\030\026\032\036\027\027\ \t\005 \022\035\017\027\017\004\036\f\022\017\005)8( )]TJ 0.031 Tw 0 -1.218 TD (\220\235\235\036\022\021 \024\021 \017\n\n\031\027\024\021\036\030\026\023\ \017\017, \030\036\022\024\n\036\027\007\024\r\026\027\024 \b\017\030\031\ \030\020\017)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.106 Tw 0 -1.218 TD [(\004\036\f\022\024\036 \035\036\004\036\027\017\036, \024\021 \022\024\021\ \024\030\024\020\024 \023\026\006\017\036\027\021\022\026 \024\021\022\026\ \026\035\026\f\034.)8.1( )]TJ 0.093 Tw T* (\215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \025\221 \024\021 \007\036\022\026\002\030\016 2024\ \020. \f\024\b\030\026\027\016\036\021\f\016 \024\002\255)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.043 Tw T* [(\036\n\027\024\036 )0.5(\024\002\030\026\024\r\026\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.307 0 Td [(\023\030\024\036\022\006\017\017 )0.5(\023\036\004\201\027\024\004\027\024\020\024 )0.5(\017\020\017\002\026)7.9( )]TJ 0.15 Tw -9.307 -1.218 Td (\002\036 \007\017\027\026\n\017\022\017, \030\026\n\036\030\024\n 30)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (20 \n\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\027\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.503 Tw T* [(\032\036\f\021\r\036\027\027\t\036 \030\036\020\017\024\027\026\030\027\t\ \036 \035\017\n\235\024\031\035\t \007\017\026\n\036\021\030\024\n)8( )]TJ 0 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (8\2269)Tj /Span<>> BDC ( )Tj EMC (\n\n.)Tj /T1_2 1 Tf 0 Tc 0 -2.436 TD (\027\200\007\220\001\005\007\n \235\003\007\005\007\006\n\220\235\004\217\ \004 \220\003\215\006\001\202 \2032)Tj /T1_0 1 Tf 0.194 Tw 0 -1.218 TD (\215\026\006\017\036\027\021 \200., 34 \035\036\021, \024\002\f\035\036\007\ \024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\027\021\016\002\030\036 2022 \020. )Tj 0.049 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\n\017 \023\030\024\016\r\035\036\027\ \017\016\n\017 \027\026\030\026\f\021\026\033\013\036\005 )Tj 0.194 Tw T* (\022\017\001\036\004\027\024\005 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\017, \235\031\027\022\006\017\024\027\026\035\034\027\t\005 \f\021\ \026\021\031\f )Tj 0.195 Tw T* [(EC)13(OG 1. \215\024)]TJ /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\035\024\027\024\f\022\024\023\017\017 \024\ \021 21.09.2022 \020. )Tj 0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\n \024\021 \026\027\031\f\026 \r\t\016\r)Tj 0 Tw (-)Tj 0.188 Tw T* (\035\036\027\024 \024\002\255\036\n\027\024\036 \023\024\035\031\006\017\ \030\022\031\035\016\030\027\024\036 \024\002\030\026\024\r\026\027\017\ \036 \023\030\024)Tj 0 Tw (-)Tj 0.166 Tw T* (\021\016\032\036\027\027\024\f\021\034\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (7 \f\n, \030\026\f\023\030\024\f\021\030\026\027\016\033\013\036\036\f\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (75% )Tj 0.185 Tw T* (\023\030\024\f\r\036\021\026 \023\030\016\n\024\005 \022\017\001\022\017\ . \206\017\f\021\024\035\024\020\017\004\036\f\022\024\036 \026\022\035\ \033\004\036)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\017\036 \024\021 22.09.2022 \020.: \026\007\036\027\024\022\026\030\ \006\017\027\024\n\026 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.151 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\235\024\022\031\f\026\n\017 \017\002\t\021\024\004\027\024\020\024 \f\035\ \017\036\024\002\030\026\024\r\026\027\017\016, )0.5(\027\017\022\024\005 )]TJ 0.121 Tw T* (\f\021\036\023\036\027\017 \035\024\022\026\004\036\f\021\r\036\027\027\ \024\f\021\017, G2. \204\217\221 \024\030\020\026\027\024\r \002\030\033\ \001)Tj 0 Tw (-)Tj 0.205 Tw T* (\027\024\005 \023\024\035\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\020\024 \021\026\026 \024\021 20.09.2022: \024\023\031\b\ \024\035\034 )Tj 0.036 Tw T* [(\023\030\016\n\024\005 \022\017\001\022\017 \031\022\026\026\027\027\024\ \005 )0.5(\r\t\001\036 \030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\ \017. )]TJ 0.245 Tw T* (\211\f\021\026\027\024\r\035\036\027 \007\017\026\020\027\024: \217\026\ \022 \023\030\016\n\024\005 \022\017\001\022\017 \fT4\026N0M0, )Tj 0 Tw T* (IIA \f\021\026\007\017\016.)Tj 0.156 Tw T* (\200 \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \023\030\017\027\026\022\024\r \021\024\035\ \f\021\024\022\017\001\036\004\027\024\005 \027\036)Tj 0 Tw (-)Tj 0.415 Tw T* (\023\030\024\b\024\007\017\n\024\f\021\017 29.09.2022 \020. \f\235\024\030\ \n\017\030\024\r\026\027\026 \022\024\035\024)Tj 0 Tw (-)Tj 0.383 Tw T* [(\f\021\024\n\026. \217\036\001\036\027\017\036\n \024\027\022\024\035\024\ \020\017\004\036\f\022\024\020\024 )0.5(\022\024\027\f\017\035\017\031\n\026 \024\021 )]TJ 0.156 Tw T* [(09.11.2022 )0.5(\020. \030\036\022\024\n\036\027\007\024\r\026\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\n )0.5(\220\021\026\023\036 )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.385 Tw T* (\r\036\007\036\027\017\036 \b\017\n\017\024\035\031\004\036\r\024\005 \021\ \036\030\026\023\017\017 \(\216\214\221\) \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031)Tj 0 Tw (-)Tj 0.312 Tw T* (\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\036\005 \023\024\ )Tj /Span<>> BDC ( )Tj EMC [(\f\b\036\n\036 XEL)35(O)17(X. \222)]TJ /Span<>> BDC ( )Tj EMC (21.11.22 )Tj 0.244 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (23.12.22)Tj /Span<>> BDC ( )Tj EMC (\020\020. \023\030\024\r\036\007\036\027\026 \216\214\221 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\034 \023\030\016\n\024\005 )Tj 0.751 Tw T* (\022\017\001\022\017, \n\036\024\030\036\022\021\026\035\034\027\024\005\ \022\035\036\021\004\026\021\022\017, \030\036\020\017\024\027\026\030\027\ \t\b )Tj 0.153 Tw T* (\035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\024\r: \212\214\ \221 \217\210\212 1,8-2 \206\030, \222\210\212 44 \206\030 )Tj 0.26 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.466 0 Td [(\024\027\t )0.5(\030\036\020\017\024\027\026\030\027\024\020\024 )0.5(\n\036\021\026\f\021\026\017\030\024\r\026\027\017\016, )0.6(\222\210\212 )0.5(50\226)]TJ -0.035 Tw -1.466 -1.218 Td (54)Tj /Span<>> BDC ( )Tj EMC (\206\030 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\031\033 \024\023\031\b\024\035\034 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\024\n\024\007\017\006\017\235\017\022\026\006\017\036\005\ )Tj 0 Tw T* (\022\026\023\036\006\017\021\026\002\017\027\024\n \023\024)Tj /Span<>> BDC ( )Tj EMC (825 \n\020/\n)Tj 5.83 0 0 5.83 418.5257 228.8618 Tm (2)Tj 10 0 0 10 421.4407 225.5318 Tm ( 2 \030\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \r\027\031\021\030\034.)Tj 0.05 Tw -11.813 -1.218 Td (\222 27.12.2022 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC (10.01.2023 \020. \023\030\024\r\036\007\036\027 1 \022\031\030\f \b\017)Tj 0 Tw (-)Tj 0.317 Tw T* [(\n\017\024\021\036\030\026\023\017\017 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 7.038 0 Td [(\f\b\036\n\036 )0.5(XEL)35.1(O)17(X, )0.5(\022\024\021\024\030\t\005 )0.5(\024\f\035\024\032\027\017\035\f\016 )]TJ 0.249 Tw -7.038 -1.218 Td (\030\026\r\017\021\017\036\n \r\t\030\026\032\036\027\027\024\005 \021\024\ \001\027\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\030\r\024\021\t, \007\017\026\030\036\036\005 )Tj 0.029 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC (\f\021., \004\021\024 \023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\026\031 \023\026\006\017\036\027\021\026 \024\021 \023\030\ \024\007\024\035\032\036\027\017\016 )Tj 0 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017.)Tj 0.216 Tw T* (\025\035\017\027\017\004\036\f\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \f\024\b\030\026\027\016\035\017\f\034 \ \024\002\017\035\034\027\t\036 \r\t)Tj 0 Tw (-)Tj 0.064 Tw T* (\007\036\035\036\027\017\016 \f\035\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\026 \023\030\016\n\024\005 \022\017\001\022\017\ , \004\021\024 \030\036\022\024 )Tj 0.173 Tw T* [(\031\b\031\007\001\026\035\024 )0.5(\022\026\004\036\f\021\r\024 )0.6(\032\017\027\017. )0.6(\215\024)]TJ /Span<>> BDC ( )Tj EMC 13.24 0 Td [(\007\026\027\027\t\n )0.5(\022\024\027\021\030\024\035\034\027\024\005 )]TJ 0.091 Tw -13.24 -1.218 Td (\025\221 \r)Tj /Span<>> BDC ( )Tj EMC (\235\036\r\030\026\035\036 2023 \020. \024\021\007\026\035\036\027\027\t\ \b \n\036\021\026\f\021\026\024\r \027\036 \r\t)Tj 0 Tw (-)Tj 0.183 Tw T* (\016\r\035\036\027\024. \204\217\221 \024\030\020\026\027\024\r \n\026\035\ \024\020\024 \021\026\026 \024\021 06.03.2023 \020.: )Tj -0.036 Tw T* [(\204\217-\022\026\030\021\017\027\026 )0.6(\024\023\031\b\024\035\036\r\024\020\024 )0.5(\024\002\030\026\024\r\026\027\017\016 )0.6(\f\030\036\007\027\036- )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.071 0 Td (\027\017\032)Tj 0 Tw (-)Tj 0.061 Tw -20.071 -1.218 Td [(\027\036\026\n\023\031\035\016\030\027\024\020\024 )0.6(\024\021\007\036\035\024\r )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 17.175 0 Td (\023\030\017\027\026\022\026\n\017 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.1902 56.0378 Tm (40)Tj ET endstream endobj 1535 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\030\t\013\n\255\n\026)11.1(\025\005\217 \r)10(\025\t\026\005\025\020\200\t\217\220 \026)11(\025\225\004\r \n\024\024\002\t\n\026)11(\004\026)11(\017 \224\005\n\022\020\004\225\004\t\n\n )]TJ 0 -1 TD [(\024\004\016)-10(\026\t\025\005\017\016\224\005\025\016)-10(\026\005\017\t\004\t\t\025\013)10(\025 \r)10(\025\020\025\005\004\r)-10(\026)11(\017\020\200\t\025\013)10.1(\025 \005\017\r\017 \016\022\024\n\r\005\025\016\017\026)11(\004\020\020\n\026\t\025\221 )]TJ T* [(\t\004\016)-10(\026)11(\017\255\n\020\200\t\025\016)-9.9(\026\200\206: \016\004\005\n\213\022\r)-9.9(\020\n\t\n\225\004\016\r\n\220 \016)-10(\020\002\225\017\004\b)]TJ 36.69 2 Td [(Ef)-31(f)-21(icacy of\022immunoth)11(er)21(apy in patients with locally adv)10(anced )]TJ 0.258 -1 Td [(color)31(ectal cancer and micr)20(osatellite instabilit)-20(y: a\022case series)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 497.5758 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 497.5758 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 460.368 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 460.368 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 396.6988 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 5.83 0 0 5.83 42.5197 733.048 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 729.718 Tm [(Moscow State Budgetar)-30.9(y Healthcar)31(e Institution \253Moscow Cit)-19.9(y Hospital named S.S.\022)-23.3(Y)40(udina, Moscow Healthcar)31(e )]TJ -0.331 -1.2 Td [(Depar)-20(tment\273 \(Dur)20(ov)10(a\022)-23.3(st., 2)46(6, bld.\022)-23.3(2, Moscow)22(, 1)125(2)47(9090, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 709.0482 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 705.7181 Tm [(Nov)10(ok)11(u)21(znetsk State Institute for P)10(ostgr)21(aduate Medical Education\022)-23.3(\230 a\022)-23.3(br)21(anch of\022)-23.2(th)11(e Russian Medical Academ)21(y )]TJ -0.331 -1.2 Td [(of\022)-23.3(Continuous Pr)20(ofessional Education. \(Str)20(oiteley A)20(v)12(e, 5, Nov)10(ok)11(u)21.1(znetsk, 65)23(4005, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 685.0482 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 681.7181 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education, Depar)-20(tment of\022)-23.3(Oncology and P)20(alliativ)12(e )]TJ -0.331 -1.2 Td [(Medicine named af)-31(ter Academician I.A)-31(.\022)-23.3(Savitsky)52.1(. \( Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, bld. 1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 661.0483 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 657.7183 Tm [(Clinical Hospital \0232 \232Medsi Gr)20(oup of\022)-23.3(Companies)-41.9(\233. \(2nd Botkinsky pr)20.1(oe)21(z)21(d, 5, bld.\022)-23.3(4, Moscow)22(, 1)125(2)23(5)35(2)35(8)34(4, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf 0.023 Tw 9 0 0 9 90.7087 627.2144 Tm [(AIM: to assess the ef)-39.9(f)-43(icacy of immuno)13(therap)12.1(y in patients with locally adv)16(anced CR)21.1(C and MSI.)]TJ 0.043 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S )0.5(A)53(ND )0.6(METHODS: )0.6(three )0.6(clinical )0.6(cases )0.6(of )0.6(patients )0.6(with )0.6(locally )0.6(adv)16(anced )0.5(colorectal )0.6(cancer )0.6(and )0.6(microsatellite )]TJ 0.023 Tw T* [(instability are p)46(resented.)]TJ 0.078 Tw T* [(RESUL)30(T)-10(S: all three patients e)-15(xper)-36.9(ienced ma)10(jor clinical and radiological im)16(p)46(rov)13(ement shor)-40(tly af)-46(ter the star)-40(t of ICI )]TJ 0.109 Tw T* [(treatment. The third patient dev)13.1(eloped a 2nd deg)14(ree immune-mediated pneumonitis that necessitated hor)-14(monal )]TJ 0.123 Tw 0 -1.111 TD [(therap)12(y and ICI ter)-14(mination. This patient go)13(t a subseq)14(uent laparoscopic r)-37(ight colectom)11(y which p)46(rov)13(ed com)16(plete )]TJ 0.053 Tw 0 -1.111 TD [(pathomor)-17.9(phologic response. R)21(ecur)-16(rent-free sur)-42(viv)16(al since the beginning of ICI treatment is 54, 30 and 18 months, )]TJ 0 Tw T* [(respectiv)13(ely)32.1(.)]TJ 0.053 Tw T* [(C)21(ON)22(CLUSION: patients with locally adv)16(anced CR)21(C and MSI ev)13(en in case of unresectability may benef)-43(it g)14(reatly af)-46(ter )]TJ 0.023 Tw T* [(immuno)13(therap)12.1(y)32(. This mak)17.1(es it crucial to ev)16(aluate the p)46(resence of MSI in this patients.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 521.9451 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colorectal cancer)61.1(, immune checkpoint inhibitors, microsatellite instability)42.1(, P)15(embrolizumab, niv)13(olumab, ipilimumab)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.029 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.2(O)-4.7(R)8.7( C)-17.5(I)-15.7(T)45.4(A)37.4(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.015 Tc -0.035 Tw 6.298 0 Td [( Z)-34.1(a)-9.1(u)-22.9(z)-11.2(o)-15.7(l)-33.1(k)-3.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-2(N)-2.8(.)-23.6(, L)3.6(y)-24.2(a)-13.1(d)-11.1(o)-10.4(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-18.8(\202)-19.6(.)-23.6(, L)3.6(y)-24.2(a)-13.1(d)-11.2(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-0.6(K)-27(.)-23.6(, F)-25.3(e)-21(d)-11.2(o)-11.8(r)-56.5(i)-3.2(n)-12(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.3(.)-26.9(S)-9.7(.)-23.5(, K)-15.9(u)-8.5(l)-16.7(i)-6.7(k)-3.7(o)-10.4(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)-23.9(A)-23.1(.)-23.5(, E)-2(r)-60.6(y)-17.2(g)-29(i)-3.3(n)]TJ /Span<>> BDC ( )Tj EMC [(D)16.3(.)40.6(V)39.6(.)-23.5(, L)-27.6(e)-21.1(d)-15.8(i)-3.3(n)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.7(.)40.6(V)39.6(.)-23.5(, M)-8.8(a)-7.6(n)-11.3(s)-8.8(u)-7.7(r)-15.8(o)-10.4(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(J)7(.)-27(S)-9.6(. Ef)-62.6(f)-63(i)-5(c)-21.6(a)-11.2(c)-42.4(y)15( )]TJ 0.023 Tc -0.027 Tw -6.303 -1.2 Td [(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(i)-3.1(m)-6.3(m)-8(u)-5(n)-11.9(o)-15.8(t)-26.1(h)-15.1(e)-12.1(r)-30.8(a)-8.8(p)-19.6(y i)-3.2(n p)-19.9(a)-18.3(t)-46.1(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h l)-20.9(o)-16.8(c)-21.5(a)-11.4(l)-28.4(l)-8.3(y a)-13(d)-17.7(v)-28.4(a)-7.6(n)-10(c)-9.7(e)-21(d c)-6.5(o)-15.6(l)-20.9(o)-11.8(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l c)-21.5(a)-7.6(n)-10(c)-9.7(e)-12.1(r a)-7.6(n)-14.5(d m)-14.5(i)-5(c)-22.3(r)-15.8(o)-15.8(s)-24.7(a)-18.2(t)-24.7(e)-18(l)-28.3(l)-16.8(i)-15.7(t)-24.7(e i)-3.2(n)-11.2(s)-29.3(t)-36.8(a)-18.2(b)-19.5(i)-7.1(l)-16.7(i)-15.8(t)-50.9(y)-21.5(: a)]TJ /Span<>> BDC ( )Tj EMC [(c)-21.5(a)-26.6(s)-22.9(e s)-22.9(e)-12.1(r)-56.4(i)-11(e)-22.8(s)-15.5(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.1(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.8(a)5.8(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)-5.6(3)-15.9(8)-24.2(\226)-29(4)-23.3(6)5(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.7(2)-1.4(5)-23.4(-)55.1(1)26.9(-)32.6(3)-15.9(8)-25.8(-)-30.2(4)-23.4(6)]TJ /T1_2 1 Tf 0.01 Tc 0.005 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.01 Tw 10.551 0 Td ( \035\t\030\031\021\020 \215\020\032\022\025\020 \003\f\027\n\024\020\025\ \030\032\031\021\025\020, \217\025\n\031\f\031\b\022\007\027\024\n\022\235\ \006\027\025\023\032 \2421 \216\031\032\031\030\024\n\031\235 \n\f\022\025\ \022\007\027\024\n\031\235 \240\031\f\017\025\022\006\013 \022\026\027\025\ \022 \205.\205.)Tj /Span<>> BDC ( )Tj EMC (\224\030\022\025\020 )Tj 0.287 Tw -10.556 -1.2 Td [(\220\027\033\020\032\023\020\026\027\025\023\020 )0.6(\016\030\032\020\021\031\031\200\032\020\025\027\025\022\t )0.7(\b\031\032\031\030\020 )0.6(\215\031\024\n\021\013, )0.5(\r\f.)]TJ /Span<>> BDC ( )Tj EMC 23.383 0 Td [(\220\r\032\031\021\020, )0.6(\030.)]TJ /Span<>> BDC ( )Tj EMC 4.96 0 Td [(26, )0.5(\024\023\032.)]TJ /Span<>> BDC ( )Tj EMC 4.132 0 Td [(2, )0.5(\215\031\024\n\021\020, )0.6(129090, )0.5(\206\031\024\024\022\t;)]TJ /Span<>> BDC ( )Tj EMC 12.164 0 Td [(+7 )0.5(\(910\) )0.6(437-10-16; )0.5(e-mail: )]TJ 0 Tw -44.639 -1.2 Td (dr.lyadova@gmail.com)Tj /T1_2 1 Tf 0.01 Tc 0.024 Tw 0.005 -1.2 Td [(ADDRESS)5( F)12.9(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.029 Tw 14.062 0 Td [( Mar)-37(ina A. L)21(yadov)16.1(a, Moscow City Hospital named S.S.)]TJ /Span<>> BDC ( )Tj EMC [(Y)39(udina, Moscow Healthcare Depar)-39.9(tment, Durov)16.1(a st., 26, )]TJ 0.023 Tw -14.067 -1.2 Td [(bld. 2, Moscow)52(, 129090, R)22(ussia; e-mail: dr)51(.lyadov)16.1(a@gmail.com)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 18.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 335.1339 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.282 Tw 10 0 0 10 42.5197 310.7779 Tm (\025\024\035\024\030\036\022\021\026\035\034\027\t\005 \030\026\022 \(\025\ \217\217\) \016\r\035\016\036\021\f\016 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.667 Tw 0 -1.218 TD [(\027\024\r\027\t\b )0.6(\023\030\017\004\017\027 )0.5(\024\027\022\024\035\024\020\017\004\036\f\022\024\005 )0.6(\026\002\024\035\036\r\026\036\n\024\f\021\017 )]TJ 0.222 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\027\024\f\021\017, \f\024\f\021\026\r\035\016\016 \023\030\ \017\002\035\017\017\021\036\035\034\027\024 10% \r\f\036\b )Tj 0.739 Tw T* (\007\017\026\020\027\024\f\021\017\030\024\r\026\027\027\t\b \024\027\022\ \024\035\024\020\017\004\036\f\022\017\b \026\002\024\035\036\r\026\027\ \017\005 )Tj 0.095 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\036 [1]. \200\026\032\027\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \025\217\217 \031)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\026 \023\026)Tj 0 Tw (-)Tj 0.353 Tw T* (\006\017\036\027\021\024\r \017\020\030\026\036\021 \027\026\035\017\004\ \017\036 \n\017\022\030\024\f\026\021\036\035\035\017\021\027\024\005 \027\ \036\f\021\026)Tj 0 Tw (-)Tj 0.306 Tw T* [(\002\017\035\034\027\024\f\021\017 \(micr)-31.9(osa)15(tell)-31(i)-24(te inst)15(abil)-30.9(i)-24(t)-10(y, MSI\), \022\024\021\024\030\026\016 )]TJ 0.074 Tw T* [(\016\r\035\016\036\021\f\016 )0.6(\f\035\036\007\f\021\r\017\036\n )0.5(\007\036\235\017\006\017\021\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.085 0 Td [(\f\017\f\021\036\n\036 )0.6(\030\036\023\026\030\026\006\017\017 )]TJ -0.034 Tw -14.085 -1.218 Td (\212\203\025 \(dMMR\) [2]. \210\023\031\b\024\035\017 \021\024\035\f\021\ \024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\017\006\017\021\024\n )Tj 0.11 Tw T* [(\030\036\023\026\030\026\006\017\017 \027\036\f\023\026\030\036\027\027\t\ \b )0.5(\024\f\027\024\r\026\027\017\005 \(dMMR\) \r\t\016\r\035\016)]TJ 0 Tw (-)Tj T* (\033\021\f\016 \023\030\017\002\035\017\017\021\036\035\034\027\024 \031\ )Tj /Span<>> BDC ( )Tj EMC (15% \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\025\217\217 [3].)Tj 0.311 Tw T* [(\211\004\017\021\t\r\026\016 \r\t\f\024\022\031\033 )0.5(\r\036\030\024\016\021\027\024\f\021\034 \r\t\030\026\032\036\027\027\024\ \020\024 )0.5(\022\035\017)]TJ 0 Tw (-)Tj 0.074 Tw T* (\027\017\004\036\f\022\024\020\024 \220\235\235\036\022\021\026 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \017\027\020\017\002\017\021\ \024\030\024\r )Tj 0.145 Tw T* (\022\024\027\021\030\024\035\034\027\t\b \021\024\004\036\022 \017\n\n\031\ \027\017\021\036\021\026 \(\230\025\221\230\) \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.29 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (dMMR/MSI \025\217\217, \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \026\022\021\017\r\027\ \024 \017)Tj 0 Tw (-)Tj 0.34 Tw T* (\031\004\026\036\021\f\016 \r\024\n\024\032\027\024\f\021\034 \023\030\024\ \r\036\007\036\027\017\016 \027\036\024\026\007\255\033\r\026\027\021\027\ \024\005 )Tj 0.264 Tw T* (\017\n\n\031\027\024\021\036\030\026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \t\b \235\024\030)Tj 0 Tw (-)Tj 0.32 Tw T* [(\n\026\b )0.5(\026\002\024\035\036\r\026\027\017\016 )0.6([4]. )0.6(\233\021\024 )0.5(\023\024\r\024\035\017\035\024 )0.6(\217\024\f\f\017\005\f\022\024\n\031 )]TJ 0.472 Tw T* (\024\002\013\036\f\021\r\031 \022\035\017\027\017\004\036\f\022\024\005 \ \024\027\022\024\035\024\020\017\017 \r\022\035\033\004\017\021\034 \007\ \026\027)Tj 0 Tw (-)Tj 0.17 Tw T* (\027\t\005 \r\026\030\017\026\027\021 \035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\007\ \026\006\017\017 )Tj 0.275 Tw 23.244 25.574 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\t\b \r\026\030\017\026\027\021\024\r \021\036\030\026\ )Tj 0 Tw (-)Tj 0.253 Tw T* (\023\017\017 \n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\024\020\024 \030\026\022\026 \021\024\035\f\021\024\005 \022\ \017\001\022\017 )Tj 0.229 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\f\026\021\036\035\035\017\021\027\024\005 \027\036\f\021\ \026\002\017\035\034\027\024\f\021\034\033 [5]. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 )Tj 0.102 Tw T* (\r\030\036\n\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\036\004\036\f\021\r\036\027\027\024\005 \035\017\021\036\030\026\ \021\031\030\036 \f\031\013\036\f\021\r\031\036\021 \024\020\030\026)Tj 0 Tw (-)Tj 0.054 Tw T* (\027\017\004\036\027\027\024\036 \004\017\f\035\024 \017\f\f\035\036\007\ \024\r\026\027\017\005, \023\024\f\r\016\013\201\027\027\t\b \007\026\027\ \027\024\005 )Tj 0 Tw T* (\023\030\024\002\035\036\n\026\021\017\022\036)Tj /Span<>> BDC ( )Tj EMC ([6,7].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 237.7099 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.242 Tw 10 0 0 10 274.9606 213.3539 Tm (\210\023\017\f\026\021\034 \021\036\004\036\027\017\036 \026\002\024\035\ \036\r\026\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021)Tj 0 Tw (-)Tj 0.429 Tw T* [(\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n )0.5(\030\026\022\024\n \024\002\024\007\024\004\027\024\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 )Tj 0.21 Tw T* (\022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\f\026\021\036\035\035\017\021\027\024\005 \027\036\f\021\ \026\002\017\035\034\027\024\f\021\034\033, \023\024\035\031)Tj 0 Tw (-)Tj 0.285 Tw T* (\004\026\r\001\017\b \021\036\030\026\023\017\033 \017\027\020\017\002\017\ \021\024\030\026\n\017 \022\024\027\021\030\024\035\034\027\t\b \021\024\ \004\036\022 )Tj 0 Tw T* (\017\n\n\031\027\017\021\036\021\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 128.1078 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 274.9606 103.7519 Tm (\027\200\007\220\001\005\007\n \235\003\007\005\007\006\n\220\235\004\217\ \004 \220\003\215\006\001\202 \2031)Tj /T1_3 1 Tf 0.105 Tw T* [(\215\026\006\017\036\027\021\022\026 )0.5(\003., )0.6(66 )0.5(\035\036\021, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.978 0 Td [(\016\027\r\026\030\036 )0.6(2021 \020. )0.6(\024\021\n\036\021\017\035\026 )0.5(\032\026)]TJ 0 Tw (-)Tj 0.101 Tw -9.978 -1.218 Td (\035\024\002\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \f\035\026\002\024\f\021\034, \023\024\027\017\032\036\ \027\017\036 \026\030\021\036\030\017\026\035\034\027\024\020\024 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 635.7187 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 626.7914 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (39)Tj ET endstream endobj 1532 0 obj [1537 0 R] endobj 1533 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 232.4105 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 232.4105 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 185.6027 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 185.6027 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-38-46)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 72.3252 696.3259 Tm [(\030\t\013\n\255\n\026)11.1(\025\005\217 \r)10(\025\t\026\005\025\020\200\t\217\220 \026)11(\025\225\004\r \n\024\024\002\t\n\026)11(\004\026)11(\017 \224\005\n\022)-23.3(\020\004\225\004\t\n\n )]TJ 2.658 -1.053 Td [(\024\004\016)-10(\026\t\025\005\017\016\224\005\025\016)-9.9(\026\005\017\t\004\t\t\025\013)10(\025 \r)10(\025\020\025\005\004\r)-10(\026)11(\017\020\200\t\025\013)10(\025 )]TJ 0.051 -1.053 Td [(\005\017\r\017 \016\022)-23.3(\024\n\r\005\025\016\017\026)11.1(\004\020\020\n\026\t\025\221 \t\004\016)-10(\026)11(\017\255\n\020\200\t\025\016)-10(\026\200\206: )]TJ 3.452 -1.053 Td [(\016\004\005\n\213\022)-23.3(\r)-10(\020\n\t\n\225\004\016\r\n\220 \016)-10(\020\002\225\017\004\b)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 611.822 Tm [(\203\017\002)31(\212\025\020\r)10(\025\b\022)-23.2(\036.\007.)]TJ 8.162 0 0 8.162 163.1991 616.484 Tm (1)Tj 0.023 Tw 14 0 0 14 167.8351 611.822 Tm [(, \035\213\202\025\b\017\022)-23.2(\235.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 250.8761 616.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 262.1968 611.822 Tm [(, \035\213\202\025\b\022)-23.2(\021.\037.)]TJ 0 Tw 8.162 0 0 8.162 331.84 616.484 Tm [(1)69(,2,3)]TJ 0.023 Tw 14 0 0 14 350.4084 611.822 Tm [(, \210\004\202\025\005\n\t\025\b\022)-23.2(\201.\001.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 454.5193 616.484 Tm [(1,)-69(3)]TJ 0 Tc 0 Tw 14 0 0 14 465.8399 611.822 Tm (, )Tj -28.212 -1.143 Td [(\037)62(\002\020\n\r)10(\025\b\017\022)-23.2(\240.\f)-31(.)]TJ 8.162 0 0 8.162 153.0072 600.484 Tm (1)Tj 0.023 Tw 14 0 0 14 157.6432 595.822 Tm [(, \240\005\217\013\n\t\022)-23.2(\201.\021.)]TJ 0 Tw 8.162 0 0 8.162 234.0061 600.484 Tm (1)Tj 0.023 Tw 14 0 0 14 238.6421 595.822 Tm [(, \035\004\202\n\t\022)-23.2(\240.\021.)]TJ 0 Tw 8.162 0 0 8.162 308.4253 600.484 Tm (4)Tj 0.023 Tw 14 0 0 14 313.0612 595.822 Tm [(, \235\017\t\016\002\005\025\b\017\022)-23.2(\207.\001.)]TJ 0 Tw 8.162 0 0 8.162 421.7924 600.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 581.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 578.1527 Tm [(\036\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \004\t\026\005 \0231 \031\037\006\ \n\024.\022)-23.3(\001.\001.\022)-23.3(\207\202\n\t\017 \201\004\224\017\005\026)11(\017\024\004\t\026)11(\017 \212\202\005\017\b\025\025\220\005\017\t\004\t\n\213 \013)10.1(\025\005\025\202\017 \235\025\016\r\b\217 )]TJ -0.331 -1.2 Td [(\(\002\020.\022)-23.3(\201\002\005\025\b\017, \202.\022)-23.3(2)46(6, \016)-10(\026\005)-30.9(.\022)-23.3(2, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(2)47(9090, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 557.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 554.1527 Tm [(\007\025\b\025\r\002)31(\212\t\004\r\n\221 \013)10(\025\016\002\202\017\005\016)-10(\026\b\004\t\t\217\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026 \002\016\025\b\004\005\204\004\t\016)-9.9(\026\b\025\b\017\t\n\213 \b\005\017\225\004\221\022)-23.3(\230 \216\n\020\n\017\020 \033\025\016\016\n\221\016\r)10(\025\221 \024\004\202\n\n\t\016\r)10(\025\221 )]TJ -0.331 -1.2 Td [(\017\r\017\202\004\024\n\n \t\004\224\005\004\005\217\b\t\025\013)10(\025 \224\005\025\216\004\016\016\n\025\t\017\020\200\t\025\013)10(\025 \025\255\005\017\212\025\b\017\t\n\213 \(\224\005-)-42(\026 \001\026\005\025\n\026)11(\004\020\004\221, \202.\022)-23.2(5, \013)62(.\022)-23.3(\007\025\b\025\r\002)31(\212\t\004\r, 65)23(4005, )]TJ 0 Tw 0 -1.2 TD (\033\025\016\016\n\213\))Tj ( )Tj 5.83 0 0 5.83 70.8661 521.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 518.1528 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \253\033\025\016\016\n\221\016\r\017\213 \024\004\202\n\ \n\t\016\r\017\213 \017\r\017\202\004\024\n\213 \t\004\224\005\004\005\217\ \b\t\025\013)10(\025 \224\005\025\216\004\016\016\n\025\t\017\020\200\t\025\013)10(\025 \025\255\005\017\212\025\b\017\t\n\213\273 )]TJ -0.331 -1.2 Td [(\235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n, \r\017\216\004\202\005\ \017 \025\t\r)10.1(\025\020\025\013\n\n \n\022)-23.3(\224\017\020\020\n\017\026\n\b\t\025\221 \024\004\202\n\n\t\217 \n\024\004\ \t\n \017\r\017\202\004\024\n\r\017 \030.\f)-30.9(.\022)-23.3(\001\017\b\n\r)10(\025\013)10(\025 )]TJ 0 -1.2 TD [(\(\006\017\005\005\n\r\017\202\t\017\213 \002\020., \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(23)46(2)69(42, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 485.4829 Tm (4)Tj 0.023 Tw 10 0 0 10 74.1775 482.1529 Tm [(\037\020\n\t\n\225\004\016\r\017\213 \255\025\020\200\t\n\017 \0232 \f\036\ \253\031)68(\005\002\224\224\017 \r)10(\025\024\224\017\t\n\221 \253\235\004\202\016\n\273 \(2-\221 \006\025\026\ \r\n\t\016\r\n\221 \224\005-)-73(\202, \202.\022)-23.3(5, \r)10(\025\005\224.\022)-23.3(4, \013)62(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(2)23(5)35(2)35(8)34(4, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.261 Tw 9 0 0 9 119.0551 451.649 Tm [(\211\211\036\220\036\001\002\036: )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC [(\025\020\024\023\031\t\212\027\027 )0.5(\021\032\027\026\t )0.5(\204\203\203\027\n\023\022\021\025\031 )0.5(\033\032\022\026\027\025\027\025\022\027 )0.5(\022\026\026\r\025\031\023\027\032\020\033\022\022 )0.5(\n\031\f\031\032\027\n\023\020\f\017\025\031\b\031 \032\020\n\020 \(\202\ \206\206\) )]TJ 0.069 Tw 0 -1.111 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\020\f\027\025\025\013\026\022 \026\027\023\020\024\023\020\016\ \020\026\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\022 \026\022\n\032\031\024\020\023\027\f\f\022\023\ \025\031\235 \025\027\024\023\020\240\022\f\017\025\031\024\023\022. \217\ \030\025\020\n\031 \021\031\016)Tj 0 Tw (-)Tj -0.021 Tw T* (\026\031\255\025\031\024\023\022 \022\024\033\031\f\017\016\031\021\020\025\ \022\t \030\020\025\025\031\b\031 \033\031\030\200\031\030\020 \021)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\022 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\023\025\031\032\020\024\033\032\031\024\023\032\020\025\027\ \025\025\013\026 \202\206\206 \031\024\023\020\005\023\024\t )Tj 0.023 Tw T* (\025\027\030\031\024\023\020\023\031\007\025\031 \022\016\r\007\027\025\025\ \013\026\022.)Tj 0.057 Tw T* (\037\036\035\034: \031\033\022\024\020\023\017 \023\027\007\027\025\022\027\ \016\020\240\031\f\027\021\020\025\022\t \033\020\006\022\027\025\023\031\ \021 \024)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\023\025\031\032\020\024\033\032\031\024\023\032\020\025\027\ \025\025\013\026 \202\206\206 \022)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\027\026 \026\022\n\032\031\024\020\023\027\f)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\f\022\023\025\031\235 \025\027\024\023\020\240\022\f\017\025\031\024\023\ \022, \033\031\f\r\007\020\021\213\022\200 \023\027\032\020\033\022\005 \ \022\025\b\022\240\022\023\031\032\020\026\022 \n\031\025\023\032\031\f\017\ \025\013\200 \023\031\007\027\n \022\026\026\r\025\022\023\027\023\020.)Tj 0.033 Tw 0 -1.111 TD [(\004\003\037\002\036\001\201 )0.5(\002)]TJ /Span<>> BDC ( )Tj EMC 5.653 0 Td [(\215\036\217\220\201: )0.5(\033\032\027\030\024\023\020\021\f\027\025\013 )0.6(\032\027\016\r\f\017\023\020\023\013 )0.5(\f\027\007\027\025\022\t )0.6(3 \033\020\006\022\027\025\023\031\021 )0.5(\(2 \026\r\255\007\022\025 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(1 )0.5(\255\027\025\212\022\025\020\), \033\031\f\r\007\020\021)]TJ 0 Tw (-)Tj 0.092 Tw -5.653 -1.111 Td [(\213\022\200 )0.6(\023\027\032\020\033\022\005 )0.5(\022\025\b\022\240\022\023\031\032\020\026\022 )0.7(\n\031\025\023\032\031\f\017\025\013\200 )0.6(\023\031\007\027\n )0.6(\022\026\026\r\025\022\023\027\023\020 )0.7(\033\031)]TJ /Span<>> BDC ( )Tj EMC 28.344 0 Td [(\033\031\021\031\030\r )0.5(\026\027\024\023\025\031\032\020\024\033\032\031\024\023\032\020\025\027\ \025\025\031\b\031 )0.6(\032\020\n\020 )]TJ 0.023 Tw -28.344 -1.111 Td (\023\031\f\024\023\031\235 \n\022\213\n\022 \024)Tj /Span<>> BDC ( )Tj EMC (\026\022\n\032\031\024\020\023\027\f\f\022\023\025\031\235 \025\027\024\023\ \020\240\022\f\017\025\031\024\023\017\005.)Tj 0.084 Tw T* (\206\036\207\210\035\034\003\201: \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\027\200 \033\020\006\022\027\025\023\031\021 \031\023\026\027\007\ \027\025\020 \021\013\032\020\255\027\025\025\020\t \033\031\f\031\255\022\ \023\027\f\017\025\020\t \n\f\022\025\022\n\031-\032\027\025\023\b\027\025\ \031\f\031\b\022\007\027\024\n\020\t \030\022\025\020)Tj 0 Tw (-)Tj 0.104 Tw T* (\026\022\n\020 \021)Tj /Span<>> BDC ( )Tj EMC (\021\022\030\027 \032\027\b\032\027\024\024\020 \031\033\r\200\031\f\022\ . \210)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\b\031 \033\020\006\022\027\025\023\020 \033\031\024\f\027\ 4 \n\r\032\024\031\021 \022\026\026\r\025\031\023\027\032\020\033\022\022\ \031\023\026\027\007\027\025\031 \022\026\026\r\025\031-\031\033\031\024\ )Tj 0 Tw (-)Tj 0.225 Tw T* (\032\027\030\031\021\020\025\025\031\027 \025\027\255\027\f\020\023\027\f\ \017\025\031\027 \t\021\f\027\025\022\027 \(\033\025\027\021\026\031\025\ \022\023 2 \024\023.\), \033\031\023\032\027\240\031\021\020\021\213\027\ \027 \023\027\032\020\033\022\022 \b\f\005\n\031\n\031\032\023\022\n\031\ \022\030\020\026\022. )Tj 0.123 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\024\021\t\016\022 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\240\200\031\030\022\026\031\024\023\017\005 \031\023\026\027\ \025\013 \022\026\026\r\025\031\023\027\032\020\033\022\022 \027\026\r \240\ \013\f\031 \021\013\033\031\f\025\027\025\031 \200\022\032\r\032\b\022\007\ \027\024\n\031\027 \f\027\007\027\025\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\236\027\026\027 )Tj 0.019 Tw T* [(\033\032\020\021\031\024\023\031\032\031\025\025\027\235 )0.5(\b\027\026\022\n\031\f\204\n\023\031\026\022\022, )0.6(\n\031\023\031\032\031\027 \033\031\030\023\021\027\032\030\022\f\031 )0.5(\025\020\f\022\007\022\027 )0.5(\033\031\f\025\031\b\031 )0.5(\033\020\023\031\026\031\032\203\031\f\031\b\022\007\027\024\n\031\b\031\ \031\023\021\027\023\020. )]TJ 0.041 Tw 0 -1.111 TD (\220\f\022\023\027\f\017\025\031\024\023\017 \240\027\016\032\027\006\022\ \030\022\021\025\031\b\031 \022\025\023\027\032\021\020\f\020 \031\023 \026\ \031\026\027\025\023\020 \025\020\007\020\f\020 \022\026\026\r\025\031\023\ \027\032\020\033\022\022 \024\031\024\023\020\021\f\t\027\023 \n)Tj /Span<>> BDC ( )Tj EMC (\025\020\024\023\031\t\212\027\026\r )Tj 0.023 Tw 0 -1.111 TD (\026\031\026\027\025\023\r 54, 30 \022)Tj /Span<>> BDC ( )Tj EMC (18 \026\027\024\t\006\027\021, \024\031\031\023\021\027\023\024\023\021\027\ \025\025\031.)Tj 0.102 Tw T* (\207\003\202\035\224\232\036\001\002\036: \025\020\f\022\007\022\027 \026\ \022\n\032\031\024\020\023\027\f\f\022\023\025\031\235 \025\027\024\023\020\ \240\022\f\017\025\031\024\023\022 \021)Tj /Span<>> BDC ( )Tj EMC (\025\027\032\027\016\027\n\023\020\240\027\f\017\025\031\235 \031\033\r\200\ \031\f\022 \023\031\f\024\023\031\235 \n\022\213\n\022 )Tj 0.023 Tw T* (\t\021\f\t\027\023\024\t \033\031\n\020\016\020\025\022\027\026 \n)Tj /Span<>> BDC ( )Tj EMC (\023\027\032\020\033\022\022 \022\025\b\022\240\022\023\031\032\020\026\022\ \n\031\025\023\032\031\f\017\025\013\200 \023\031\007\027\n \022\026\026\ \r\025\022\023\027\023\020.)Tj /T1_2 1 Tf 0.01 Tc 0.08 Tw 8 0 0 8 70.9061 266.3798 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.085 Tw 8.555 0 Td ( \n\031\f\031\032\027\n\023\020\f\017\025\013\235 \032\020\n, \022\025\b\ \022\240\022\023\031\032\013 \n\031\025\023\032\031\f\017\025\013\200 \023\ \031\007\027\n \022\026\026\r\025\025\031\b\031 \031\023\021\027\023\020\ , \026\022\n\032\031\024\020\023\027\f\f\022\023\025\020\t \025\027\024\023\ \020\240\022\f\017\025\031\024\023\017, )Tj 0.023 Tw -8.56 -1.2 Td (\033\027\026\240\032\031\f\022\016\r\026\020\240, \025\022\021\031\f\r\026\ \020\240, \022\033\022\f\022\026\r\026\020\240)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.021 Tc -0.039 Tw -10.401 -2.617 Td [(\020\036\017)4.6( )0.5(\016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.011 Tc -0.034 Tw 8.943 0 Td [( )0.5(\003\026\031\024\035\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 4.724 0 Td [(\210.\203., )0.6(\214\016\007\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 5.476 0 Td [(\204.\202., )0.5(\214\016\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.055 0 Td [(\200.\025., )0.6(\205\036\007\024\030\017\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.062 0 Td [(\212.\222., )0.5(\025\031\035\017\022\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.303 0 Td [(\213.\202., )0.5(\213\030\t\020\017\027)]TJ /Span<>> BDC ( )Tj EMC 5.359 0 Td [(\212.\200., )0.5(\214\036\007\017\027)]TJ /Span<>> BDC ( )Tj EMC 5.026 0 Td [(\213.\200., )0.5(\204\026\027\f\031\030\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.847 0 Td [(\224.\222.)11( )]TJ 0.023 Tc 0.135 Tw -54.8 -1.2 Td [(\230\027\020\017\002\017\021\024\030\t )0.6(\022\024\027\021\030\024\035\034\027\t\b )0.6(\021\024\004\036\022 )0.5(\017\n\n\031\027\017\021\036\021\026 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 21.871 0 Td [(\035\036\004\036\027\017\017 )0.6(\n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\027\036\027\027\ \024\020\024 )0.6(\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 )0.5(\030\026\022\026 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 26.797 0 Td [(\n\017\022\030\024\f\026\021\036\035\035\017\021\027\024\005)23( )]TJ 0.006 Tc -0.035 Tw -48.668 -1.2 Td (\027\036\f\021\026\002\017\035\034\027\024\f\021\034\033: \f\036\030\017\ \016 \022\035\017\027\017\004\036\f\022\017\b \f\035\031\004\026\036\r. \ )Tj /T1_0 1 Tf -0.006 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.035 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (38\22646. https://doi.org/10.33878/2073-7556-2026-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (25-1-38-46)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 82.1271 159.4334 Tm [(Ef)-31(f)-21(icacy of\022)-23.3(immunoth)11(er)21.1(apy in patients with locally adv)10(anced )]TJ 0.129 -1.167 Td [(color)31(ectal cancer and micr)20.1(osatellite instabilit)-19.9(y: a\022)-23.3(case series)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 113.9295 Tm [(Oleg\022)-23.3(N.\022)-23.2(Z)21(au)21(z)10(olk)11(ov)]TJ 8.162 0 0 8.162 178.5471 118.5915 Tm (1)Tj 0.023 Tw 14 0 0 14 183.183 113.9295 Tm [(, Marina\022)-23.2(\f)-31(.\022)-23.3(L)20(y)21(adov)10(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 300.388 118.5915 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 311.7086 113.9295 Tm [(, Vladimir\022)-23.2(K.\022)-23.3(L)20(y)21(adov)]TJ 0 Tw 8.162 0 0 8.162 425.9454 118.5915 Tm [(1)69(,2,3)]TJ 14 0 0 14 444.5138 113.9295 Tm (, )Tj -26.689 -1.143 Td [(Denis\022)-23.2(S.\022)-23.3(F)20(edorinov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 175.3406 102.5915 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 186.6612 97.9295 Tm [(, Ev)10(geniy)21(a\022)-23.2(A)-31(.\022)-23.3(K)31(ulik)11(ov)10(a)]TJ 0 Tw 8.162 0 0 8.162 313.89 102.5915 Tm (1)Tj 0.023 Tw 14 0 0 14 318.5259 97.9295 Tm [(, Dmitrii\022)-23.2(V)62(.\022)-23.3(Er)-31(y)10(gin)]TJ 0 Tw 8.162 0 0 8.162 417.0399 102.5915 Tm (1)Tj 14 0 0 14 421.6759 97.9295 Tm (, )Tj -25.058 -1.143 Td [(Ev)10(genii\022)-23.2(V)62(.\022)-23.3(Ledin)]TJ 8.162 0 0 8.162 158.9888 86.5915 Tm (4)Tj 0.023 Tw 14 0 0 14 163.6248 81.9295 Tm [(, Julia\022)-23.2(S.\022)-23.3(Mansur)20(ov)10(a)]TJ 0 Tw 8.162 0 0 8.162 278.3933 86.5915 Tm (1)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 460.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 451.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.115 56.0378 Tm (38)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 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1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 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1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 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)]TJ 2.765 -1 Td [(f)-21(istulas in patients with Cr)20(ohn\236)63(s disease)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.023 Tw 10 0 0 10 42.5197 724.8299 Tm (AUTHORS CONTRIBUTION)Tj /T1_2 1 Tf 0.67 Tw 0 -1.218 TD [(S)7(t)-12.8(ud)-10.9(y c)3.8(o)0.8(nce)-0.6(p)-12.3(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n)15.4(:)]TJ /T1_3 1 Tf [( I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.8(n)1.9(o)3.3(s)4.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)6.2(r)-40.2(y)3.8(u)4.6(k)-18.5(i)8.4(n)]TJ /T1_2 1 Tf 0.535 Tw T* [(D)-1.6(a)-8.4(t)-27.7(a )0.6(c)3.7(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.8(n )0.6(a)2.4(n)-4.6(d )0.5(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.5(i)7.1(n)-1.9(g)9(:)]TJ /T1_3 1 Tf [( )0.5(I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC 17.652 0 Td [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC 1.524 0 Td [(A)3.8(n)1.9(o)3.3(s)4.9(o)-0.6(v)33.6(, )]TJ 0.177 Tw -19.176 -1.218 Td [(T)49.7(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(E)22(r)-40.2(y)-1(s)9.6(h)1.9(o)-0.6(v)10.9(a)-14(, R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)0.7(h)6.2(r)-40.2(y)3.8(u)4.6(k)-18.5(i)8.5(n)-6(, O)-5.5(k)-17.5(s)7.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. )]TJ 0 Tw T* [(F)19.1(om)-1.1(e)-2.6(n)7.5(k)13(o)-3.7(, D)-10.9(y)1.8(l)3.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)18.4(D)24(. M)1.8(c)-8.5(C)4.2(r)2.4(e)-6.2(e)-1.7(r)-40.2(y)]TJ /T1_2 1 Tf -0.002 Tc 0.002 Tw 0 -1.218 TD [(S)5(t)-29.7(a)-10.4(t)-39.4(i)0.7(s)-21.9(t)-39.4(i)3.2(c)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 7.243 0 Td [( R)7.2(om)4.3(a)-0.7(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)0.7(h)6.2(r)-40.2(y)3.8(u)4.6(k)-18.4(i)8.4(n)]TJ /T1_2 1 Tf -0.009 Tc 0.009 Tw -7.243 -1.218 Td [(W)-5.9(r)-57(i)-15(t)-46.4(i)-1.9(n)-10.9(g:)]TJ /T1_3 1 Tf 0 Tc 0.003 Tw 3.318 0 Td [( T)49.7(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(E)22(r)-40.2(y)-1(s)9.6(h)1.9(o)-0.6(v)10.8(a)-14(, I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.8(n)1.9(o)3.3(s)4.9(o)-0.6(v)33.6(, R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. )]TJ -0.008 Tc 0.008 Tw -3.318 -1.218 Td [(K)-7.3(h)-1.8(r)-48.2(y)-4.2(u)-3.3(k)-26.5(in)]TJ /T1_2 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 3.238 0 Td [( V)25.9(al)4.8(e)-1.6(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(L)-8.8(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-6.1(e)-2.6(n)6.2(i)11.1(s)4.9(e)-2.6(n)7.5(k)12.9(o)-3.7(, E)19.8(d)5.2(u)4.1(ar)1.5(d)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-6.1(e)-2.6(n)6.2(i)11(s)4.9(e)-2.5(n)7.5(k)12.9(o)]TJ /T1_1 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_2 1 Tf 0.082 Tw 0 -1.218 TD (\202\027\024\f\024\r \230\r\026\027 \222\036\030\020\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031\033\013\017\005 \024\021\007\036\ )Tj 0 Tw (-)Tj -0.029 Tw 0 -1.218 TD (\035\024\n \n\026\035\024\017\027\r\026\017\r\027\024\005 \023\030\024\022\ \021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\230\037 \022\024\ \035\024)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; )Tj 0 Tw T* (ORCID 0000-0002-9015-2600)Tj 0.118 Tw T* (\213\030\t\001\024\r\026 \221\026\021\034\016\027\026 \202\030\021\201\n\ \024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\022\024\035\024\023\030\024\022\021\024\035\024\020\ )Tj 0.156 Tw T* (\024\021\007\036\035\036\027\017\016 \017\027\027\024\r\026\006\017\024\027\ \027\024\005 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032)Tj 0 Tw (-)Tj 0.036 Tw T* (\007\017\f\006\017\023\035\017\027\026\030\027\024\005 \b\017\030\031\030\ \020\017\017 \205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\ \024\022\021\024)Tj 0 Tw (-)Tj 0.088 Tw T* (\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0009-0004-6076-5192)Tj 0.117 Tw T* [(\216\030\033\022\017\027 )0.5(\217\024\n\026\027 \224\030\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 10.424 0 Td [(\227 \022.\n.\027., )0.5(\f\021\026\030\001\017\005 \027\026\031\004\027\t\005 )]TJ 0.745 Tw -10.424 -1.218 Td (\f\024\021\030\031\007\027\017\022 \024\021\007\036\035\026 \n\026\035\024\ \017\027\r\026\017\r\027\024\005 \023\030\024\022\021\024\035\024\020\017\ \017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0003-05\ 56-1782)Tj 0.117 Tw 23.244 29.227 Td (\205\024\n\036\027\022\024 \210\022\f\026\027\026 \224\030\034\036\r\027\ \026)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \007\024\006\036\027\021, \026\r\036\007\031)Tj 0 Tw (-)Tj 0.38 Tw T* (\033\013\026\016 \035\026\002\024\030\026\021\024\030\017\036\005 \022\035\ \017\027\017\004\036\f\022\024\005 \023\026\021\024\235\017\017\024\035\ \024\020\017\017 )Tj 0.221 Tw T* (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0000-0001-96\ 03-6988)Tj 0.489 Tw T* (\212\036\027\017\f\036\027\022\024 \200\026\035\036\030\017\005 \214\026\ \030\017\024\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024)Tj 0 Tw (-)Tj 0.469 Tw T* (\235\036\f\f\024\030, \020\035\026\r\027\t\005 \r\030\026\004 \211\003 \253\ \200\017\021\036\002\f\022\017\005 \024\002\035\026\f\021\027\024\005 )Tj 0.497 Tw 0 -1.218 TD (\022\035\017\027\017\004\036\f\022\017\005 \f\023\036\006\017\026\035\017\ \017\030\024\r\026\027\027\t\005 \006\036\027\021\030\273; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0003-2394-340X)Tj 0.076 Tw T* (\212\036\027\017\f\036\027\022\024 \233\007\031\026\030\007 \200\026\035\ \036\030\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\023\030\024\022\021\024\035\024\020 \211\003 )Tj 0.25 Tw T* (\253\200\017\021\036\002\f\022\017\005 \024\002\035\026\f\021\027\024\005\ \022\035\017\027\017\004\036\f\022\017\005 \f\023\036\006\017\026\035\017\ \017\030\024)Tj 0 Tw (-)Tj T* (\r\026\027\027\t\005 \006\036\027\021\030\273; ORCID 0009-0002-4265-9885\ )Tj 0.025 Tw T* (\204\026\022\025\030\017\030\017 \212\017\035\026\027 \204\026\005\022\035\ \212\026\030\036\035)Tj /Span<>> BDC ( )Tj EMC (\227 \022\035\017\027\017\004\036\f\022\017\005 \024\030\007\017)Tj 0 Tw (-)Tj 0.356 Tw 0 -1.218 TD [(\027\026\021\024\030 )0.5(\024\021\007\036\035\036\027\017\016 )0.5(\017\027\027\024\r\026\006\017\024\027\027\024\005 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )]TJ 0.108 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\017\f\006\017\023\035\017\027\026\030\027\024\005 \b\017\030\ \031\030\020\017\017 \205\206\207\211 \253\203\204\230\037 \022\024\035\024\ )Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \202.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; )Tj 0 Tw T* (ORCID 0009-0000-7174-1787)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(Iv)-15(an S. Anosov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9015-2600)Tj T* [(T)40(a)15(t)-10(y)22(ana A. Er)-23.9(y)-13(shov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-6076-5192)Tj T* [(R)11(oman Y)35(u. Khr)-23.9(yuk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0556-1782)Tj T* [(Ok)-10(sana Y)35(u. F)10.1(omenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9603-6988)Tj T* [(V)25(aler)-24(y L. Denisenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2394-340X)Tj T* [(Eduar)-24(d V. Denisenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0002-4265-9885)Tj T* [(Dyl)-16(an M.D. McCr)-23.9(eer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0000-7174-1787)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 396.0239 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.259 Tw 8 0 0 8 42.5197 383.1892 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gecse)Tj /Span<>> BDC ( )Tj EMC (KB, Bemelman)Tj /Span<>> BDC ( )Tj EMC [(W, K)-16(amm)]TJ /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(gl)30(obal consensus )]TJ 0.347 Tw -1.296 -1.25 Td [(on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(cl)-16(assif)-27.9(ica)15(t)-32(ion, dia)-17(gnosis and mul)56(t)-32(idisc)-23.9(ipl)-31(inar)-24(y tr)-23.9(ea)15(tment )]TJ 0.285 Tw 0 -1.25 TD (of)Tj /Span<>> BDC ( )Tj EMC [(per)-37(ianal f)-27.9(istul)-31(ising Cr)-32(ohn\241s disease. )]TJ /T1_3 1 Tf 0 Tw (Gut.)Tj /T1_2 1 Tf 0.285 Tw ( 2014;63:1381\2261392. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/gutjnl-2013-306709)Tj 0 0 0 1 k /GS1 gs -0.019 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(ichtenstein)]TJ /Span<>> BDC ( )Tj EMC [(GR, L)35(of)-28(tus)]TJ /Span<>> BDC ( )Tj EMC [(EV, Isaa)-17(cs)]TJ /Span<>> BDC ( )Tj EMC [(KL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)16(CG Cl)-31(inical Guidel)-30.9(ine: )]TJ 0.004 Tc 0.349 Tw -1.296 -1.25 Td [(Mana)-16.8(gement of)]TJ /Span<>> BDC ( )Tj EMC [(Cr)-31.8(ohn\241s Disease in A)15.2(dul)56.2(ts. )]TJ /T1_3 1 Tf (Am J Gastroenterol)Tj /T1_2 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2018;113\(4\):481\226517. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/ajg.2018.27)Tj 0 0 0 1 k /GS1 gs -0.081 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\222., \203\026\027\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\207.\202., \200\026\030\007\026\027\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\036\030\017\026\027\026\035\034\027\t\036 )Tj 0.033 Tw -1.296 -1.25 Td [(\f\r\017\013\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.676 0 Td [(\002\024\035\036\027\017 )0.5(\025\030\024\027\026 )0.5(\(\024\002\024\030 )0.5(\035\017\021\036\030\026\021\031\030\t\). )]TJ /T1_3 1 Tf 0 Tw 15.22 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_2 1 Tf ( )Tj 0.016 Tw -19.896 -1.25 Td [(2023;22\(1\):128\226137. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 10.787 0 Td (10.33878/2073-7556-2023-22-1-128-137)Tj 0 0 0 1 k /GS1 gs ( )Tj -0.007 Tw -10.787 -1.25 Td (/ Anosov)Tj /Span<>> BDC ( )Tj EMC [(I.S., Nanaev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(B.A., V)25(ar)-23.9(d)42(any)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)30(er)-37(ianal f)-28(istul)-15.9(as in )]TJ 0.12 Tw T* [(Cr)-32(ohn\241s disease \(r)-24(ev)-15.9(iew\). )]TJ /T1_3 1 Tf 0 Tw [(K)18(olop)46(roktologia.)]TJ /T1_2 1 Tf 0.12 Tw ( 2023;22\(1\):128\226137. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2023-22-1-128-137)Tj 0 0 0 1 k /GS1 gs 0.218 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Cadeddu)Tj /Span<>> BDC ( )Tj EMC [(F, Sal)-31(is)]TJ /Span<>> BDC ( )Tj EMC [(F, L)-31.9(isi)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(ple)-18(x anal f)-28(istul)-15.9(a r)-24(emains )]TJ 0.005 Tw -1.296 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(challenge )0.5(for )0.5(col)30(or)-24(ec)-16(t)15(al )0.5(sur)-32(geon. )]TJ /T1_3 1 Tf 14.191 0 Td [(Int J )0.5(Color )0.5(Dis.)]TJ /T1_2 1 Tf ( 2015;30:595\226603. )Tj 0 Tw -14.191 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-014-2104-7)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.302 0 Td (Gu)Tj /Span<>> BDC ( )Tj EMC [(P, K)25.1(uenzig)]TJ /Span<>> BDC ( )Tj EMC [(ME, K)-15.9(apl)-15.9(an)]TJ /Span<>> BDC ( )Tj EMC [(GG, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10.1(ecal Incont)-31.9(inence in)2( )]TJ 0 Tc -0.041 Tw -1.302 -1.25 Td [(Infl)-16(amma)15.1(t)17(or)-24(y Bo)-14(wel Disease: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-13(stema)15(t)-31.9(ic R)12.9(ev)-15.9(iew and Me)-12(t)15(a-Anal)35(y)-12.9(sis. )]TJ /T1_3 1 Tf -0.012 Tw T* [(Inf)-22(lamm Bow)12(el Dis)]TJ /T1_2 1 Tf [(. 2018;24\(6\):1280\2261290. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ibd/izx109)Tj 0 0 0 1 k /GS1 gs 0.349 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(angas)]TJ /Span<>> BDC ( )Tj EMC [(E, Hi)-24(t)-30(tuen)]TJ /Span<>> BDC ( )Tj EMC [(KM, Ma)15.1(t)-32(ik)-17(ainen)]TJ /Span<>> BDC ( )Tj EMC [(M. Anor)-24(ec)-16(t)15(al func)-15.9(t)-32(ion in )]TJ 0.023 Tw -1.296 -1.25 Td [(Cr)-32(ohn\241s disease. )]TJ /T1_3 1 Tf (Ann Chir Gynecol.)Tj /T1_2 1 Tf ( 1992;81:43\22647.)Tj 0.098 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\222., \213\030\t\001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\224., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\030\036\007\017\022\021\024\030\t )Tj 0.003 Tc 0.35 Tw -1.296 -1.25 Td (\030\026\r\017\021\017\016 \026\027\026\035\034\027\024\005 \017\027\022\ \024\027\021\017\027\036\027\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.013 Tc 0.482 Tw T* (\027\t\n\017 \023\024\030\026\032\036\027\017\016\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\017 \025\030\024\027\026. )Tj /T1_3 1 Tf -0.013 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_2 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj -0.027 Tw -27.638 -1.25 Td (2025;4\(24\):62\22670. / Anosov)Tj /Span<>> BDC ( )Tj EMC [(I.S., Er)-23.9(y)-13(shov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(T.A., Khr)-23.9(yuk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(R.Y)35(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.059 Tw T* [(P)35(r)-24(edic)-15.9(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(anal incont)-31.9(inence in p)32(a)15(t)-32(ients wi)-24(t)-13(h per)-36.9(ianal f)-27.9(istul)-31(izing )]TJ 0.023 Tw T* [(Cr)-32(ohn\241s disease. )]TJ /T1_3 1 Tf 0 Tw [(K)18(olop)46(roctologia.)]TJ /T1_2 1 Tf 0.023 Tw ( 2025;4\(24\):62\22670. \(in Russ.\).)Tj 0.145 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)40(ar)-24(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(A)16(G, Gor)-23.9(d)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(PH, Har)-24(dcastle)]TJ /Span<>> BDC ( )Tj EMC (JD. A)Tj /Span<>> BDC ( )Tj EMC [(cl)-16(assif)-28(ica)15(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(istul)-16(a-)]TJ 0 Tw -1.296 -1.25 Td (in-ano. )Tj /T1_3 1 Tf 0.023 Tw 3.184 0 Td (Br J Surg.)Tj /T1_2 1 Tf [( 1976;63\(1\):1\22612. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.1800630102)Tj 0 0 0 1 k /GS1 gs 0.018 Tc 0.656 Tw 25.871 35 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.35 0 Td (\231\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\224., \221\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)18( )]TJ 0.014 Tc 0.511 Tw -1.35 -1.25 Td [(\222\235\017\027\022\021\036\030\024\n\036\021\030\017\004\036\f\022\026\ \016 \020\030\026\007\026\006\017\016 \027\036\007\024\f\021\026\021\024\ \004\027\024\f\021\017 \026\027\026\035\034\027\024\020\024)14( )]TJ 0 Tc 0 Tw T* (\f\235\017\027\022\021\036\030\026. )Tj /T1_3 1 Tf 5.101 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_2 1 Tf 0.167 Tw [( 2016; 4\(58\);54-59./ S)-16(hel)35(ygin Y.A., )]TJ 0.041 Tw -5.101 -1.25 Td [(F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35(u., T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sphinc)-16(ter)-32(ome)-11.9(tr)-24(y gr)-33(ad)42(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (anal )Tj 0.004 Tc 0.35 Tw T* [(sphinc)-16.2(ter insuf)-56.3(f)-28.1(ic)-24.2(iency. )]TJ /T1_3 1 Tf -0.004 Tw [(K)17.8(olop)45.8(roctologia.)]TJ /T1_2 1 Tf 0.35 Tw [( 2016; 4\(58\);54-59. \(in)4( )]TJ 0 Tc 0 Tw T* (Russ.\))Tj 0.173 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)-24(t)-29.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(F, S)-24(cald)42.1(afer)-24(r)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(F, P)40(ar)-24(ell)30.1(o)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-23.9(ec)-16(t)15(al F)10(unc)-16(t)-32(ion and )]TJ 0.116 Tw -1.796 -1.25 Td [(Q)-16(ual)-31(i)-23.9(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ife in IBD P)40(a)15(t)-32(ients W)-16(i)-24(t)-12.9(h A)]TJ /Span<>> BDC ( )Tj EMC [(P)30(er)-37(ianal Com)10(pl)-16(aint. )]TJ /T1_3 1 Tf [(J In)11(v)13(est )]TJ 0 Tw T* (Surg.)Tj /T1_2 1 Tf 0.023 Tw [( 2021;34\(5\):547\226553. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/08941939.2019.1658830)Tj 0 0 0 1 k /GS1 gs 0.029 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)29(ollebr)-24(eg)17.1(t)]TJ /Span<>> BDC ( )Tj EMC [(PF, v)-15(an Bodegr)-33(aven)]TJ /Span<>> BDC ( )Tj EMC [(AA, Mar)-23.9(kus-de K)20(w)-12(aadstenie)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (TML, )Tj 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(e)-11.5(t)]TJ /Span<>> BDC 0.832 0 Td ( )Tj EMC [(a)0.6(l)0.5(.)0.5( I)0.5(m)10.6(p)32.5(a)-16.5(c)-15.5(t)0.5(s)0.5( o)0.5(f)]TJ /Span<>> BDC 6.817 0 Td ( )Tj EMC [(p)0.5(e)0.6(r)-36.5(i)0.5(a)0.5(n)0.5(a)0.6(l)0.5( d)0.5(i)0.5(s)0.5(e)0.6(a)0.5(s)0.5(e)0.5( a)0.6(n)0.5(d)0.5( f)16.5(a)0.6(e)0.5(c)0.5(a)0.5(l)0.5( i)0.6(n)0.5(c)0.5(o)0.5(n)0.5(t)-31.5(i)0.6(n)0.5(e)0.5(n)0.5(c)0.5(e)0.5( o)0.5(n)1( )]TJ 0 Tc 0.232 Tw -7.649 -1.25 Td [(qual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife and em)10(pl)30(oyment in 1092 p)32(a)15(t)-32(ients wi)-23.9(t)-13(h infl)-16(amma)]TJ 0 Tw (-)Tj 0.02 Tw T* [(t)17(or)-24(y bo)-14(wel disease. )]TJ /T1_3 1 Tf [(Aliment Phar)-13.9(macol Ther)]TJ /T1_2 1 Tf (. 2018;47\(9\):1253\2261260. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/apt.14599)Tj 0 0 0 1 k /GS1 gs 0.042 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ap)32(a)15(t)-13(hanasopoul)30.1(os)]TJ /Span<>> BDC ( )Tj EMC [(AA, K)-15.9(a)15(tsanos)]TJ /Span<>> BDC ( )Tj EMC [(KH, T)39.9(a)15(tsioni)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-24(eased )]TJ -0.024 Tw -1.796 -1.25 Td [(f)16(a)15(t)-32(igabil)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xter)-14.9(nal anal sphinc)-16(ter in infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease: )]TJ 0.258 Tw T* [(signif)-28(icance in fecal ur)-31.9(gency and incont)-32(inence)]TJ /T1_3 1 Tf (. J Crohns Colitis.)Tj /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2010;4\(5\):553\226560. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cr)-32(ohns.2010.05.002)]TJ 0 0 0 1 k /GS1 gs 0.001 Tc 0.349 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.799 0 Td [(L)35.3(unniss)]TJ /Span<>> BDC ( )Tj EMC [(P)35.4(J, Gl)-15.7(adman)]TJ /Span<>> BDC ( )Tj EMC [(MA, He)-11.7(tzer)]TJ /Span<>> BDC ( )Tj EMC [(FH, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-23.7(isk f)16.3(a)-16.6(c)-15.7(t)17.4(or)-9.7(s in)1( )]TJ 0 Tc 0.233 Tw -1.799 -1.25 Td [(a)-17(cquir)-23.9(ed f)16(aecal incont)-32(inence. )]TJ /T1_3 1 Tf (J R Soc Med.)Tj /T1_2 1 Tf ( 2004;97\(3\):111\226116. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/014107680409700303)Tj 0 0 0 1 k /GS1 gs 0.008 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(or)-22(t)17.1(on)]TJ /Span<>> BDC ( )Tj EMC [(C, Dible)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(LB, Basse)-12(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(P. F)20(aecal incont)-32(inence in infl)-16(amma)]TJ 0 Tw (-)Tj -0.042 Tw -1.796 -1.25 Td [(t)17(or)-24(y bo)-14(wel disease: asso)-15.9(c)-24(ia)15(t)-32(ions and ef)-56(fec)-15.9(t on qual)-31(i)-24(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-30.9(ife. )]TJ /T1_3 1 Tf (J Crohns )Tj 0 Tw T* (Colitis.)Tj /T1_2 1 Tf 0.023 Tw [( 2013;7\(8\):e302\22611. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cr)-32(ohns.2012.11.004)]TJ 0 0 0 1 k /GS1 gs 0.242 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (de Codes)Tj /Span<>> BDC ( )Tj EMC (LMG, de Jesus)Tj /Span<>> BDC ( )Tj EMC [(A)16(CC, de Codes)]TJ /Span<>> BDC ( )Tj EMC [(JJG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24(ec)-16(t)15(al )]TJ 0.012 Tc 0.455 Tw -1.796 -1.25 Td [(F)9.7(unc)-16.3(t)-32.3(ion and Cl)-31.3(inical Char)-33.3(a)-17.3(c)-16.3(ter)-37.3(ist)-32.3(ics Asso)-16.3(c)-24.3(ia)14.7(ted wi)-24.3(t)-13.3(h F)19.7(aecal)12( )]TJ 0 Tc 0.309 Tw T* [(Incont)-32(inence in P)40(a)15.1(t)-32(ients wi)-23.9(t)-13(h Cr)-32(ohn\241s Disease. )]TJ /T1_3 1 Tf (J Crohns Colitis.)Tj /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2023;17\(8\):1252\2261261. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/jjad048)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8768 56.0378 Tm (37)Tj ET endstream endobj 1540 0 obj <>/Border[0 0 0]/H/N/Rect[57.2978 360.485 152.257 351.189]/Subtype/Link/Type/Annot>> endobj 1541 0 obj <>/Border[0 0 0]/H/N/Rect[132.94 330.485 201.523 321.189]/Subtype/Link/Type/Annot>> endobj 1542 0 obj 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(\002\024\035\036\036 \004\026\f\021\t\n \030\026\r\017\021\017\036\n \016\ \r\035\036\027\017\005 \203\202\222 [13\22615].)Tj 0.172 Tw T* [(\200 )0.5(\007\026\027\027\024\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\017, )0.5(\027\036\f\n\024\021\030\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 16.431 0 Td (\020\036\021\036\030\024\020\036\027\027\t\005 )Tj 0.328 Tw -16.431 -1.218 Td [(\b\026\030\026\022\021\036\030 )0.6(\023\030\024\r\036\007\036\027\027\t\b )0.5(\024\023\036\030\026\021\017\r\027\t\b )0.5(\r\n\036\001\026\021\036\035\034\f\021\r, )]TJ -0.024 Tw T* (\n\t \023\030\024\026\027\026\035\017\017\030\024\r\026\035\017 \017\b \ \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 \026\027\026\035\034)Tj 0 Tw (-)Tj 0.197 Tw 0 -1.218 TD (\027\024\020\024 \f\235\017\027\022\021\036\030\026. \222\021\026\021\017\ \f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\ \017\005 )Tj 0.17 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \022\035\017\027\017\004\036\f\022\017\b \023\ \030\024\016\r\035\036\027\017\005 \203\202\222 \022\026\022 \007\024, \021\ \026\022 )Tj 0.097 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\t\016\r\035\036\027\ \024 \027\036 \002\t\035\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,84\). \221\036\n )Tj 0.135 Tw T* (\027\036 \n\036\027\036\036, \007\026\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \024\007\027\024\020\024 \024\023\036\030\026\021\017\ \r\027\024\020\024 \r\n\036)Tj 0 Tw (-)Tj 0.033 Tw T* (\001\026\021\036\035\034\f\021\r\026, \023\030\024\f\035\036\032\017\r\026\ \036\021\f\016 \021\036\027\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\031\b\031\007\001\036\027\017\033 )Tj 0.24 Tw T* [(\f\031\002\255\036\022\021\017\r\027\t\b )0.6(\f\017\n\023\021\024\n\024\r )0.5(\026\027\026\035\034\027\024\005 )0.6(\017\027\022\024\027\021\017\027\036\027\006\017\017, )]TJ 0.305 Tw 0 -1.218 TD (\004\021\024 \023\024\007\021\r\036\030\032\007\026\036\021\f\016 \031\r\ \036\035\017\004\036\027\017\036\n \n\036\007\017\026\027\t \002\026\035\ \035\024\r )Tj 0 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22.1(e)-18(xner \f)]TJ /Span<>> BDC ( )Tj EMC (3-\b \007\024)Tj /Span<>> BDC ( )Tj EMC (5-\021\017 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007\).)Tj 0.045 Tw 0 -1.218 TD (\215\030\017 \026\027\026\035\017\036 \007\026\027\027\t\b \f\235\017\027\ \022\021\036\030\024\n\036\021\030\017\017 \r\t\016\r\035\036\027\024 \007\ \024)Tj 0 Tw (-)Tj 0.177 Tw T* (\f\021\024\r\036\030\027\024\036 \031\r\036\035\017\004\036\027\017\036 \ \004\026\f\021\024\021\t \030\026\r\017\021\017\016 \203\202\222 \023\024\ \f\035\036 )Tj 0.153 Tw T* [(\024\023\036\030\026\006\017\017 )0.5(\()]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.153 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 6.482 0 Td [(0,0004\). )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\021\024\032\036 )0.5(\r\030\036\n\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024)Tj 0 Tw (-)Tj 0.09 Tw -6.482 -1.218 Td (\r\026\027\027\024\n \026\027\026\035\017\036 \024\021\007\036\035\034\027\ \t\b \023\024\022\026\026\021\036\035\036\005 \026\027\024\030\036\022\021\ \026\035\034)Tj 0 Tw (-)Tj 0.356 Tw T* (\027\024\005 \n\026\027\024\n\036\021\030\017\017 \023\024\035\031\004\036\ \027\027\t\036 \030\036\031\035\034\021\026\021\t, \020\035\026\r\027\t\ \n )Tj 0.399 Tw T* (\024\002\030\026\024\n, \002\t\035\017 \024\002\031\f\035\024\r\035\036\ \027\t \f\027\017\032\036\027\017\036\n \f\030\036\007\027\036\020\024 )Tj 0.182 Tw T* (\007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \024\021\030\026\032\026\033\013\017\n )Tj 0.077 Tw T* (\021\024\027\031\f \r\027\031\021\030\036\027\027\036\020\024 \026\027\026\ \035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.077 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj 0.065 Tw T* (\215\030\017\n\036\004\026\021\036\035\034\027\024, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\024 \027\024\030\n\026\035\034)Tj 0 Tw (-)Tj 0.704 Tw T* [(\027\t\n\017 )0.5(\023\024\022\026\026\021\036\035\016\n\017 )0.6(\f\235\017\027\022\021\036\030\024\n\036\021\030\017\017 )0.6(\r\t\016\r\035\036\027\024 )]TJ 0.122 Tw T* (\f\027\017\032\036\027\017\036 \n\026\027\024\n\036\021\030\017\004\036\f\ \022\017\b \023\024\022\026\026\021\036\035\036\005 \023\024\f\035\036 \ \024\023\036)Tj 0 Tw (-)Tj 0.04 Tw T* (\030\026\006\017\017 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.04 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\), \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033)Tj 0 Tw (-)Tj 0.07 Tw T* [(\013\036\005\f\016 )0.6(\030\026\027\036\036 )0.5(\026\027\026\035\034\027\024\005 )0.5(\017\027\022\024\027\021\017\027\036\027\006\017\036\005 )0.5(1\2263)]TJ /Span<>> BDC ( )Tj EMC 18.829 0 Td (\f\021\036\023\036\027\017 )Tj 0.056 Tw -18.829 -1.218 Td (\024\023\036\030\026\006\017\016 \027\036 \023\030\017\r\024\007\017\035\ \026 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n\031 \031\b\031\007\001\036\027\ \017\033 )Tj 0.402 Tw T* [(\235\031\027\022\006\017\017 \026\023\017\030\026\021\036\035\034\027\024\ \020\024 )0.5(\026\023\023\026\030\026\021\026 \023\030\016\n\024\005 \022\017\001\022\ \017 )]TJ 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,23\2261\).)Tj 0.058 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \002\t\035\024 \r\t\016\r\035\ \036\027\024 \027\036\f\024\024\021\r\036\021\f\021\r\017\036 \n\036\032\ )Tj 0 Tw (-)Tj -0.039 Tw T* (\007\031 \f\031\002\255\036\022\021\017\r\027\024\005 \024\006\036\027\022\ \024\005 \235\031\027\022\006\017\017 \007\036\030\032\026\027\017\016 \023\ \026\006\017\036\027)Tj 0 Tw (-)Tj -0.041 Tw T* (\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\022\021\017\r\027\t\n\017 \n\026\027\024\n\036\021\030\017\ \004\036\f\022\017\n\017 \023\024\022\026\026\021\036\035\016)Tj 0 Tw (-)Tj 0.107 Tw T* (\n\017, \004\021\024 \023\024\007\021\r\036\030\032\007\026\036\021 \027\ \026\004\017\n\024\f\021\034 \017\027\f\021\030\031\n\036\027\021\026\035\ \034\027\024\005 )Tj 0.379 Tw T* (\007\017\026\020\027\024\f\021\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\017 \235\031\027\022\006\017\017 \026\023\017\ \030\026\021\036\035\034\027\024\020\024 )Tj 0.085 Tw T* [(\026\023\023\026\030\026\021\026 )0.5(\023\030\016\n\024\005 \022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\035\026\027\017\030\024\r\026\027\017\017 )0.5(\024\002\255\036\n\026 )0.5(\b\017)]TJ 0 Tw (-)Tj 0.247 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\026)Tj 0 Tw (-)Tj T* (\027\026\035\034\027\t\n\017 \023\030\024\016\r\035\036\027\017\016\n\017\ \207\025.)Tj 0.165 Tw T* (\200 \017\f\f\035\036\007\024\r\026\027\017\017 \027\036 \031\f\021\026\027\ \024\r\035\036\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026)Tj 0 Tw (-)Tj 0.547 Tw T* (\004\017\n\t\b \023\030\036\007\017\022\021\024\030\024\r \030\026\r\017\ \021\017\016 \016\r\035\036\027\017\005 \026\027\026\035\034\027\024\005\ )Tj 0.37 Tw T* (\017\027\022\024\027\021\017\027\036\027\006\017\017 \022\026\022 \f\031\ \002\255\036\022\021\017\r\027\024\005 \022\035\017\027\017\004\036\f\022\ \024\005 \(\r )Tj 0.178 Tw T* [(\f\024\024\021\r\036\021\f\021\r\017\017 )0.6(\f\024 )0.5(\001\022\026\035\024\005 )0.5(\200\036\022\f\027\036\030\), )0.6(\021\026\022 )0.5(\024\002\255\036\022\021\017\r\027\024\005 )]TJ 0.394 Tw T* [(\017\027\f\021\030\031\n\036\027\021\026\035\034\027\024\005 )0.6(\(\023\024 )0.5(\007\026\027\027\t\n \f\235\017\027\022\021\036\030\024\n\036\021\030\017\ \017\). )]TJ -0.076 Tw T* (\200\t\016\r\035\036\027\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\r\026\030\017\026\027\021\027\024\n \026\027\026\035\017\036\ \235\026\022\021\024\030\t \030\017)Tj 0 Tw (-)Tj -0.006 Tw T* (\f\022\026 \030\026\r\017\021\017\016 \203\202\222 \023\024\f\035\036 \024\ \023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 )Tj -0.03 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\024\022\031\023\027\024\f\021\017 \n\024\020\031\021 \017\020\030\ \026\021\034 \f\r\024\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\031\020\031\002\035\036\027\017\017 )Tj 0.086 Tw T* (\r\t\030\026\032\036\027\027\024\f\021\017 \f\017\n\023\021\024\n\024\r \ \027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 \026\027\026\035\ \034\027\024)Tj 0 Tw (-)Tj 0.195 Tw T* (\020\024 \032\024\n\026, \027\024 \027\036 \016\r\035\016\033\021\f\016 \ \027\036\026\r\017\f\017\n\t\n\017. \200\036\030\024\016\021\027\024, )Tj 0.133 Tw T* (\235\026\022\021 \023\030\024\r\036\007\036\027\017\016 \024\023\036\030\ \026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \026\022\021\017\r\027\024\020\024 \r\024\f)Tj 0 Tw (-)Tj 0.245 Tw T* [(\023\026\035\036\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\031\002\006\024\r\t\b )0.5(\017\n\036\027\036\027\017\005 \r)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 )0.5(\023\030\016\n\024\005 )]TJ 0.126 Tw T* (\022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 \023\024\r\ \t\001\026\036\021 \030\017\f\022 \030\026\r\017\021\017\016 )Tj -0.008 Tw T* (\235\031\027\022\006\017\024\027\026\035\034\027\t\b \027\026\030\031\001\ \036\027\017\005 \026\023\017\030\026\021\036\035\034\027\024\020\024 \026\ \023\023\026\030\026)Tj 0 Tw (-)Tj -0.025 Tw T* (\021\026 \023\030\016\n\024\005 \022\017\001\022\017, \024\007\027\026\022\ \024 \007\026\027\027\024\036 \023\030\036\007\023\024\035\024\032\036\027\ \017\036 \021\030\036)Tj 0 Tw (-)Tj T* (\002\031\036\021 \023\030\024\r\036\007\036\027\017\016 \007\026\035\034\ \027\036\005\001\017\b \017\f\f\035\036\007\024\r\026\027\017\005.)Tj 0.37 Tw 23.244 64.543 Td (\215\024\035\031\004\036\027\027\t\036 \007\026\027\027\t\036 \023\024\007\ \004\036\030\022\017\r\026\033\021 \027\036\024\002\b\024\007\017\n\024\f\ \021\034 )Tj -0.072 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\017\r\017\007\031\026\035\034\027\024\n \023\024\007\b\024\007\ \036 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\031 \021\026\022\021\017\022\017 \b\017\030\031\030\020\ \017)Tj 0 Tw (-)Tj -0.017 Tw T* (\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\215\215\207\025. \212\035\016 \024\002\036\f\023\036\004\036\027\017\016\ )Tj -0.02 Tw T* (\020\030\026\n\024\021\027\024\005 \f\021\030\026\021\036\020\017\017 \035\ \036\004\036\027\017\016 \r\026\032\027\024 \022\024\n\023\035\036\022\f\ \027\024\036 \024\002)Tj 0 Tw (-)Tj 0.094 Tw T* (\f\035\036\007\024\r\026\027\017\036 \023\026\006\017\036\027\021\024\r,\ \023\030\024\r\036\007\036\027\017\036 \026\007\036\022\r\026\021\027\024\ \005 \023\030\024)Tj 0 Tw (-)Tj 0.056 Tw T* (\021\017\r\024\030\036\006\017\007\017\r\027\024\005 \021\036\030\026\023\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\024\036 \r\f\022\030\t\021\017\036 \ )Tj 0.19 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\036 \020\027\024\005\027\t\b \ \026\021\036\022\024\r. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \f\035\036\007\031)Tj 0 Tw (-)Tj 0.239 Tw 0 -1.218 TD (\036\021 \023\024\n\027\017\021\034, \004\021\024 \023\030\017\004\017\027\ \t \026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\ \027\006\017\017 )Tj 0.053 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 \002\024\035\ \034\027\t\b \n\027\024\020\024\020\030\026\027\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\017 \024\007\017\027 )Tj -0.034 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\024\r \024\023\036\030\026\021\017\r\027\024\020\024 \ \r\n\036\001\026\021\036\035\034\f\021\r\026 \027\036 \n\024\032\036\021\ \020\026)Tj 0 Tw (-)Tj 0.031 Tw T* (\030\026\027\021\017\030\024\r\026\021\034 \253\017\007\036\026\035\034\027\ \024\020\024\273 \235\031\027\022\006\017\024\027\026\035\034\027\024\020\ \024 \030\036\031\035\034)Tj 0 Tw (-)Tj 0.002 Tw T* (\021\026\021\026. \222\021\024\017\021 \024\021\n\036\021\017\021\034, \004\ \021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \017\n\036\036\021\f\016 \030\ \016\007 )Tj 0.504 Tw 0 -1.218 TD (\007\024\f\021\026\021\024\004\027\024 \f\031\013\036\f\021\r\036\027\027\ \t\b \024\020\030\026\027\017\004\036\027\017\005, \f\021\026\r\016\013\017\ \b )Tj 0.319 Tw 0 -1.218 TD (\023\024\007 \f\024\n\027\036\027\017\036 \023\024\035\031\004\036\027\027\ \t\036 \030\036\031\035\034\021\026\021\t: \030\036\021\030\024\f\023\036\ \022)Tj 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD [(\021\017\r\027\t\005 )0.5(\b\026\030\026\022\021\036\030 \007\026\027\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\017\b )0.5(\027\036\023\024\035\027\024\036 \024\023\017\f\026\027\017\036; )]TJ 0.254 Tw T* (\027\026\004\017\021\036\035\034\027\026\016 \020\036\021\036\030\024\020\ \036\027\027\024\f\021\034 \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tw (-)Tj 0.115 Tw T* (\007\024\r\026\027\017\036 \023\026\006\017\036\027\021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\024\f\021\017 \002\024\035\036\027\017 )Tj -0.01 Tw T* (\025\030\024\027\026, \023\024\035\031\004\026\036\n\024\005 \022\024\027\ \f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\017, \026\ \027\026\n\027\036)Tj 0 Tw (-)Tj -0.02 Tw T* [(\031 )0.5(\023\036\030\017\026\027\026\035\034\027\t\b )0.6(\023\030\024\016\r\035\036\027\017\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC [(\b\026\030\026\022\021\036\030\031 )0.6(\023\036\030\036\027\036\f\036\027)]TJ 0 Tw (-)Tj 0.12 Tw T* [(\027\t\b \024\023\036\030\026\021\017\r\027\t\b \r\n\036\001\026\021\036\ \035\034\f\021\r; )0.5(\027\026\035\017\004\017\036 \023\026\006\017\036\027\021\024\r )]TJ 0.347 Tw T* (\f\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\n\024\005; 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(\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026, \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \026\027\026\n\027\036\026 )Tj 0.051 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\036\022\031\013\036\020\024 \f\024\f\021\024\016\027\017\016 \023\026\ \006\017\036\027\021\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\002\f\031\032\007\036\027\017\036 )Tj 0.417 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\024\023\036\030\026\006\017\024\027\027\024\n \220\021\026\023\036\ \r\036\030\024\016\021\027\024\f\021\017 \f\027\017\032\036\027\017\016\ )Tj -0.003 Tw T* (\235\031\027\022\006\017\017 \026\027\026\035\034\027\024\020\024 \f\235\ \017\027\022\021\036\030\026 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n )Tj 0.296 Tw T* (\004\017\f\035\036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\005 \027\036\024\002\b\024\007\017\n\024\f\021\ \034\033 \036\020\024 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0 0 1 232.6909 658.9667 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 263.872 658.9667 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 42.5197 658.7167 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 627.7384 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 658.7167 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 627.7384 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 658.7167 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 627.7384 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 627.7384 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 627.4884 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 615.7102 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 170.3287 627.4884 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 615.7102 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 232.6909 627.4884 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 615.7102 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 263.872 615.7102 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 42.5197 615.4602 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 584.482 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 615.4602 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 584.482 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 615.4602 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 584.482 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 584.482 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 584.232 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 553.2538 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 584.232 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 553.2538 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 584.232 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 553.2538 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 553.2538 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 553.0038 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 522.0256 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 553.0038 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 522.0256 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 553.0038 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 522.0256 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 522.0256 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 521.7756 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 509.9974 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 170.3287 521.7756 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 509.9974 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 232.6909 521.7756 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 509.9974 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 263.872 509.9974 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 42.5197 509.7474 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 497.9692 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 170.3287 509.7474 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 497.9692 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 232.6909 509.7474 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 497.9692 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 263.872 497.9692 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 42.5197 497.7192 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 457.1409 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 170.3287 497.7192 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 457.1409 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 232.6909 497.7192 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 457.1409 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 263.872 457.1409 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 42.5197 456.8909 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 425.9127 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 456.8909 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 425.9127 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 456.8909 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 425.9127 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 425.9127 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 425.6627 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 413.8845 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 170.3287 425.6627 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 413.8845 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 232.6909 425.6627 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 413.8845 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 263.872 413.8845 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 42.5197 413.6345 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 382.6563 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 413.6345 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 382.6563 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 413.6345 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 382.6563 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 382.6563 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 382.4063 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 341.8281 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 170.3287 382.4063 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 341.8281 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 232.6909 382.4063 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 341.8281 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 263.872 341.8281 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 42.5197 341.5781 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 320.1999 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 170.3287 341.5781 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 320.1999 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 232.6909 341.5781 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 320.1999 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 263.872 320.1999 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 42.5197 319.9499 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 298.5717 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 170.3287 319.9499 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 298.5717 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 232.6909 319.9499 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 298.5717 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 263.872 298.5717 cm 0 0 m 0 21.128 l S Q q 1 0 0 1 42.5197 298.3217 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 267.3434 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 298.3217 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 267.3434 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 298.3217 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 267.3434 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 267.3434 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 267.0934 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 236.1152 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 267.0934 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 236.1152 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 267.0934 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 236.1152 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 236.1152 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 235.8652 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 195.287 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 170.3287 235.8652 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 195.287 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 232.6909 235.8652 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 195.287 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 263.872 195.287 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 42.5197 195.037 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 164.0588 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 195.037 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 164.0588 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 195.037 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 164.0588 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 164.0588 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 163.8088 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 152.0306 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 170.3287 163.8088 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 152.0306 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 232.6909 163.8088 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 152.0306 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 263.872 152.0306 cm 0 0 m 0 11.528 l S Q q 1 0 0 1 42.5197 151.7806 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 120.8024 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 170.3287 151.7806 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 120.8024 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 232.6909 151.7806 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 120.8024 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 263.872 120.8024 cm 0 0 m 0 30.728 l S Q q 1 0 0 1 42.5197 120.5524 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 42.7697 79.9742 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 170.3287 120.5524 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 170.3287 79.9742 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 232.6909 120.5524 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 232.6909 79.9742 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 263.872 79.9742 cm 0 0 m 0 40.328 l S Q q 1 0 0 1 42.5197 79.7242 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 170.3287 79.7242 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 232.6909 79.7242 cm 0 0 m 31.431 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 90.9654 673.863 Tm (\203\004\220\003\002\006\013)Tj 10.819 0 Td (\017\016 \(95% \031\034\))Tj /T1_3 1 Tf 8.586 0.001 Td (p)Tj /T1_4 1 Tf -25.075 -1.504 Td (\200\024\030\026\f\021 \(\035\036\021\))Tj 16.319 0 Td (1,02)Tj /Span<>> BDC ( )Tj EMC (\(0,97;1,08\))Tj 8.173 0 Td (0,39)Tj -24.492 -1.504 Td (\215\024\035)Tj 1.063 -1.2 Td (\240\036\027\f\022\017\005)Tj 0 -1.2 TD (\204\031\032\f\022\024\005)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,79)Tj /Span<>> BDC ( )Tj EMC (\(0,25;2,49\))Tj 8.173 2.4 Td (0,69)Tj -24.492 -3.904 Td (\230\204\221 \(\022\020/\n2\))Tj 16.319 0 Td (1,09)Tj /Span<>> BDC ( )Tj EMC (\(0,95;1,25\))Tj 8.173 0 Td (0,23)Tj -24.492 -1.504 Td (\025\031\030\036\027\017\036)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (1,46)Tj /Span<>> BDC ( )Tj EMC (\(0,45;4,74\))Tj 8.173 2.4 Td (0,53)Tj -24.492 -3.904 Td (\222\024\023\031\021\f\021\r\031\033\013\017\036 \026\002\024\035\036\r\ \026\027\017\016)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,36)Tj /Span<>> BDC ( )Tj EMC (\(0,08;1,69\))Tj 8.173 2.4 Td (0,19)Tj -24.492 -3.904 Td (\203\026\035\017\004\017\036 \f\021\024\n\t \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,59)Tj /Span<>> BDC ( )Tj EMC (\(0,07;4,81\))Tj 8.173 2.4 Td (0,62)Tj -24.492 -3.904 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \215\215\207\025 \(\035\036\021\))Tj 16.569 0 Td (1,1)Tj /Span<>> BDC ( )Tj EMC (\(0,89;1,37\))Tj 7.923 0 Td (0,34)Tj -24.492 -1.504 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \207\025 \(\035\036\021\))Tj 16.319 0 Td (0,95)Tj /Span<>> BDC ( )Tj EMC (\(0,88;1,02\))Tj 8.173 0 Td (0,17)Tj -24.492 -1.504 Td (\202\022\021\017\r\027\024\f\021\034 \002\024\035\036\027\017 \025\030\024\ \027\026 )Tj T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\017)Tj 1.063 -1.2 Td (\217\036\n\017\f\f\017\016)Tj T* (\212\026)Tj 18.175 1.2 Td (1)Tj -2.669 -1.2 Td (1,2)Tj /Span<>> BDC ( )Tj EMC (\(0,35;4,14\))Tj 7.923 3.6 Td (0,77)Tj -24.492 -5.104 Td (\215\030\024\022\021\017\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\035\024\027\024\f\022\024\023\017\017)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (2,04)Tj /Span<>> BDC ( )Tj EMC (\(0,54;7,75\))Tj 8.173 2.4 Td (0,29)Tj -24.492 -3.904 Td (\232\026\f\021\024\021\026 \f\021\031\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017)Tj 16.319 0 Td (0,98)Tj /Span<>> BDC ( )Tj EMC (\(0,76;1,27\))Tj 8.173 0 Td (0,87)Tj -24.492 -1.504 Td (\215\030\017\036\n \020\035\033\022\024\022\024\030\021\017\022\024\f\021\ \036\030\024\017\007\024\r)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,61)Tj /Span<>> BDC ( )Tj EMC (\(0,16;2,34\))Tj 8.173 2.4 Td (0,47)Tj -24.492 -3.904 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\215\207\025 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,29)Tj /Span<>> BDC ( )Tj EMC (\(0,09;1,02\))Tj 7.923 3.6 Td (0,053)Tj -24.242 -5.104 Td (\200\f\022\030\t\021\017\036 \023\026\030\026\023\030\024\022\021\017\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 )Tj 0 -1.2 TD (\(\022\024\035-\r\024\))Tj 16.319 0 Td (1,36)Tj /Span<>> BDC ( )Tj EMC (\(0,71;2,62\))Tj 8.173 1.2 Td (0,36)Tj -24.492 -2.704 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\215\207\025 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \(\022\024\035-\r\024\))Tj 16.319 0 Td (1,75)Tj /Span<>> BDC ( )Tj EMC (\(0,65;4,74\))Tj 8.173 1.2 Td (0,27)Tj -24.492 -2.704 Td (\217\026\007\017\022\026\035\034\027\t\036 \024\023\036\030\026\006\017\017\ )Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,31)Tj /Span<>> BDC ( )Tj EMC (\(0,04;2,49\))Tj 8.173 2.4 Td (0,27)Tj -24.492 -3.904 Td (\215\030\024\022\021\017\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \221\217\211\003\230)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,47)Tj /Span<>> BDC ( )Tj EMC (\(0,15;1,52\))Tj 8.423 2.4 Td (0,2)Tj -24.742 -3.904 Td (\216\024\007 \f\r\017\013\026)Tj 1.063 -1.2 Td (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\017\027\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 18.175 2.4 Td (1)Tj -2.919 -1.2 Td (0,81)Tj /Span<>> BDC ( )Tj EMC (\(0,18;3,76\))Tj T* (2,03)Tj /Span<>> BDC ( )Tj EMC (\(0,55;7,41\))Tj 8.173 3.6 Td (0,49)Tj -24.492 -5.104 Td (\003\026\021\036\022\017)Tj 1.063 -1.2 Td (\203\036\021)Tj T* (\212\026)Tj 18.175 1.2 Td (1)Tj -3.169 -1.2 Td (1,004)Tj /Span<>> BDC ( )Tj EMC (\(0,21;4,86\))Tj 8.423 2.4 Td (0,99)Tj -24.492 -3.904 Td (\025\024\035-\r\024 \026\021\036\022\024\r)Tj 16.319 0 Td (0,84)Tj /Span<>> BDC ( )Tj EMC (\(1,59;0,64\))Tj 8.173 0 Td (0,68)Tj -24.492 -1.504 Td (\222\021\024\n\026 \023\024\f\035\036 \024\023\036\030\026\006\017\017)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,87)Tj /Span<>> BDC ( )Tj EMC (\(0,23;3,36\))Tj 8.173 2.4 Td (0,84)Tj -24.492 -3.904 Td (\215\030\024\r\036\007\036\027\017\036 \007\030\036\027\017\030\031\033\013\ \036\005 )Tj T* (\035\026\021\036\022\f\027\024\005 \035\017\020\026\021\031\030\t)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,59)Tj /Span<>> BDC ( )Tj EMC (\(0,19;1,92\))Tj 8.173 3.6 Td (0,39)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.011 Tw 9 0 0 9 274.9606 730.483 Tm (\020\004\206\f\t\204\004 13.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\030\025\031\203\020\n\023\031\032\025\013\235 \020\025\020\f\022\016\ \203\020\n\023\031\032\031\021, \021\f\022\t\005\212\022\200 )Tj 0 Tw T* (\024\025\022\255\027\025\022\027 \205\220 \003\202\033 \033\031\024\f\027\ \031\033\027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.178 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-21.2(3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.151 Tw 4.019 0 Td [( U)7.5(n)1.7(i)-2.9(v)6.3(a)-4.2(r)-39(i)1.5(a)-9.1(t)-1.6(e a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s o)4(f p)-6.2(a)-4.2(r)3.3(a)-5.1(m)-5.3(e)-8.6(t)-1.6(e)-6(r)-14.9(s a)-0.6(f)-42.3(f)-13.4(e)-10.9(c)-32.4(t)-29.1(i)3.9(n)-0.6(g A)-18.4(A)10(R)6.7(P )]TJ 0.008 Tc -0.008 Tw -4.019 -1.2 Td [(d)2.7(e)-2.9(cr)6(e)0.5(a)0.8(s)8.5(e)]TJ ET /GS2 gs q 1 0 0 1 274.9606 693.5811 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 679.8957 cm 0 0 m 0 13.435 l S Q q 1 0 0 1 402.7697 693.5811 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 679.8957 cm 0 0 m 0 13.435 l S Q q 1 0 0 1 465.1319 693.5811 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 679.8957 cm 0 0 m 0 13.435 l S Q q 1 0 0 1 496.313 679.8957 cm 0 0 m 0 13.435 l S Q q 1 0 0 1 274.9606 679.6457 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 665.9683 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 402.7697 679.6457 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 665.9683 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 465.1319 679.6457 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 665.9683 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 496.313 665.9683 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 274.9606 665.7183 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 632.8408 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 665.7183 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 632.8408 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 665.7183 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 632.8408 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 632.8408 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 632.5908 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 618.9135 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 402.7697 632.5908 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 618.9135 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 465.1319 632.5908 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 618.9135 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 496.313 618.9135 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 274.9606 618.6635 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 585.786 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 618.6635 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 585.786 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 618.6635 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 585.786 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 585.786 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 585.536 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 552.6586 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 585.536 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 552.6586 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 585.536 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 552.6586 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 552.6586 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 552.4086 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 519.5311 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 552.4086 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 519.5311 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 552.4086 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 519.5311 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 519.5311 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 519.2811 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 505.6037 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 402.7697 519.2811 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 505.6037 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 465.1319 519.2811 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 505.6037 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 496.313 505.6037 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 274.9606 505.3537 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 491.6763 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 402.7697 505.3537 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 491.6763 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 465.1319 505.3537 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 491.6763 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 496.313 491.6763 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 274.9606 491.4263 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 448.9489 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 402.7697 491.4263 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 448.9489 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 465.1319 491.4263 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 448.9489 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 496.313 448.9489 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 274.9606 448.6989 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 415.8214 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 448.6989 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 415.8214 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 448.6989 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 415.8214 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 415.8214 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 415.5714 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 401.894 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 402.7697 415.5714 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 401.894 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 465.1319 415.5714 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 401.894 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 496.313 401.894 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 274.9606 401.644 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 368.7666 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 401.644 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 368.7666 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 401.644 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 368.7666 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 368.7666 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 368.5166 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 326.0392 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 402.7697 368.5166 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 326.0392 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 465.1319 368.5166 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 326.0392 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 496.313 326.0392 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 274.9606 325.7892 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 302.5117 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 402.7697 325.7892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 302.5117 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 465.1319 325.7892 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 302.5117 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 496.313 302.5117 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 274.9606 302.2617 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 278.9843 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 402.7697 302.2617 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 278.9843 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 465.1319 302.2617 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 278.9843 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 496.313 278.9843 cm 0 0 m 0 23.027 l S Q q 1 0 0 1 274.9606 278.7343 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 245.8569 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 278.7343 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 245.8569 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 278.7343 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 245.8569 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 245.8569 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 245.6069 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 203.1295 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 402.7697 245.6069 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 203.1295 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 465.1319 245.6069 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 203.1295 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 496.313 203.1295 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 274.9606 202.8795 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 170.002 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 202.8795 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 170.002 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 202.8795 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 170.002 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 170.002 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 169.752 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 156.0746 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 402.7697 169.752 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 156.0746 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 465.1319 169.752 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 156.0746 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 496.313 156.0746 cm 0 0 m 0 13.427 l S Q q 1 0 0 1 274.9606 155.8246 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 122.9472 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 402.7697 155.8246 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 122.9472 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 465.1319 155.8246 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 122.9472 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 496.313 122.9472 cm 0 0 m 0 32.627 l S Q q 1 0 0 1 274.9606 122.6972 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 275.2106 80.2198 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 402.7697 122.6972 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 402.7697 80.2198 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 465.1319 122.6972 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 465.1319 80.2198 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 496.313 80.2198 cm 0 0 m 0 42.227 l S Q q 1 0 0 1 274.9606 79.9698 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 402.7697 79.9698 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 465.1319 79.9698 cm 0 0 m 31.431 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 323.4064 683.6992 Tm (\203\004\220\003\002\006\013)Tj 10.819 0 Td (\017\016 \(95% \031\034\))Tj /T1_3 1 Tf 8.586 0.001 Td (p)Tj /T1_4 1 Tf -25.075 -1.741 Td (\200\024\030\026\f\021 \(\035\036\021\))Tj 16.319 0 Td (1,02)Tj /Span<>> BDC ( )Tj EMC (\(0,97;1,08\))Tj 8.173 0 Td (0,42)Tj -24.492 -1.741 Td (\215\024\035)Tj 1.063 -1.2 Td (\240\036\027\f\022\017\005)Tj 0 -1.2 TD (\204\031\032\f\022\024\005)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,79)Tj /Span<>> BDC ( )Tj EMC (\(0,25;2,49\))Tj 8.173 2.4 Td (0,69)Tj -24.492 -4.141 Td (\230\204\221 \(\022\020/\n2\))Tj 16.319 0 Td (1,05)Tj /Span<>> BDC ( )Tj EMC (\(0,92;1,19\))Tj 8.173 0 Td (0,48)Tj -24.492 -1.741 Td (\025\031\030\036\027\017\036)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -3.169 -1.2 Td (1,005)Tj /Span<>> BDC ( )Tj EMC (\(0,29;3,45\))Tj 8.423 2.4 Td (0,99)Tj -24.492 -4.141 Td (\222\024\023\031\021\f\021\r\031\033\013\017\036 \026\002\024\035\036\r\ \026\027\017\016)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,94)Tj /Span<>> BDC ( )Tj EMC (\(0,27;3,22\))Tj 8.173 2.4 Td (0,92)Tj -24.492 -4.141 Td (\203\026\035\017\004\017\036 \f\021\024\n\t \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,59)Tj /Span<>> BDC ( )Tj EMC (\(0,07;4,81\))Tj 8.173 2.4 Td (0,62)Tj -24.492 -4.141 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \215\215\207\025 \(\035\036\021\))Tj 16.319 0 Td (1,16)Tj /Span<>> BDC ( )Tj EMC (\(0,91;1,49\))Tj 8.173 0 Td (0,23)Tj -24.492 -1.741 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \207\025 \(\035\036\021\))Tj 16.069 0 Td (0,94)Tj /Span<>> BDC ( )Tj EMC (\(0,87;1,007\))Tj 8.423 0 Td (0,07)Tj -24.492 -1.741 Td (\202\022\021\017\r\027\024\f\021\034 \002\024\035\036\027\017 \025\030\024\ \027\026 )Tj T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\027\024\f\022\024\023\017\017)Tj 1.063 -1.2 Td (\217\036\n\017\f\f\017\016)Tj T* (\212\026)Tj 18.175 1.2 Td (1)Tj -2.669 -1.2 Td (1,2)Tj /Span<>> BDC ( )Tj EMC (\(0,35;4,14\))Tj 7.923 3.6 Td (0,77)Tj -24.492 -5.341 Td (\215\030\024\022\021\017\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\035\024\027\024\f\022\024\023\017\017)Tj 1.063 -1.2 Td (\203\036\021)Tj T* (\212\026)Tj 18.175 1.2 Td (1)Tj -2.827 -1.2 Td (1,33)Tj /Span<>> BDC ( )Tj EMC (\(0,39;459\))Tj 8.081 2.4 Td (0,65)Tj -24.492 -4.141 Td (\232\026\f\021\024\021\026 \f\021\031\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017)Tj 16.319 0 Td (0,96)Tj /Span<>> BDC ( )Tj EMC (\(0,75;1,24\))Tj 8.173 0 Td (0,77)Tj -24.492 -1.741 Td (\215\030\017\036\n \020\035\033\022\024\022\024\030\021\017\022\024\f\021\ \036\030\024\017\007\024\r)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,94)Tj /Span<>> BDC ( )Tj EMC (\(0,27;3,22\))Tj 8.173 2.4 Td (0,92)Tj -24.492 -4.141 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\215\207\025 )Tj 0 -1.2 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.669 -1.2 Td (0,3)Tj /Span<>> BDC ( )Tj EMC (\(0,09;1,02\))Tj 7.673 3.6 Td (0,053)Tj -24.242 -5.341 Td (\200\f\022\030\t\021\017\036 \023\026\030\026\023\030\024\022\021\017\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 )Tj 0 -1.2 TD (\(\022\024\035-\r\024\))Tj 16.319 0 Td (1,54)Tj /Span<>> BDC ( )Tj EMC (\(0,74;3,19\))Tj 8.173 1.2 Td (0,24)Tj -24.492 -2.941 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\215\207\025 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \(\022\024\035-\r\024\))Tj 16.319 0 Td (2,43)Tj /Span<>> BDC ( )Tj EMC (\(0,68;8,66\))Tj 8.173 1.2 Td (0,17)Tj -24.492 -2.941 Td (\215\030\024\022\021\017\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \221\217\211\003\230)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,47)Tj /Span<>> BDC ( )Tj EMC (\(0,15;1,52\))Tj 8.423 2.4 Td (0,2)Tj -24.742 -4.141 Td (\216\024\007 \f\r\017\013\026)Tj 1.063 -1.2 Td (\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\017\027\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 18.175 2.4 Td (1)Tj -2.919 -1.2 Td (0,63)Tj /Span<>> BDC ( )Tj EMC (\(0,13;3,12\))Tj 0.25 -1.2 Td (1,3)Tj /Span<>> BDC ( )Tj EMC (\(0,35;4,87\))Tj 7.923 3.6 Td (0,69)Tj -24.492 -5.341 Td (\003\026\021\036\022\017)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,44)Tj /Span<>> BDC ( )Tj EMC (\(0,05;3,52\))Tj 8.173 2.4 Td (0,44)Tj -24.492 -4.141 Td (\025\024\035-\r\024 \026\021\036\022\024\r)Tj 16.319 0 Td (0,96)Tj /Span<>> BDC ( )Tj EMC (\(0,58;1,61\))Tj 8.173 0 Td (0,89)Tj -24.492 -1.741 Td (\222\021\024\n\026 \023\024\f\035\036 \024\023\036\030\026\006\017\017)Tj 1.063 -1.2 Td (\212\026)Tj 0 -1.2 TD (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (1,35)Tj /Span<>> BDC ( )Tj EMC (\(0,39;4,65\))Tj 8.173 2.4 Td (0,64)Tj -24.492 -4.141 Td (\215\030\024\r\036\007\036\027\017\036 \007\030\036\027\017\030\031\033\013\ \036\005 )Tj T* (\035\026\021\036\022\f\027\024\005 \035\017\020\026\021\031\030\t)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 18.175 1.2 Td (1)Tj -2.919 -1.2 Td (0,59)Tj /Span<>> BDC ( )Tj EMC (\(0,19;1,92\))Tj 8.173 3.6 Td (0,39)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7645 56.0378 Tm (35)Tj ET endstream endobj 1570 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.336 Tw 10 0 0 10 70.8661 615.2279 Tm [(\200\t\023\024\035\027\036\027 \031\027\017\r\026\030\017\026\027\021\027\ \t\005 )0.5(\026\027\026\035\017 \235\026\022\021\024\030\024\r, \r\035\017\016)]TJ 0 Tw (-)Tj 0.25 Tw 0 -1.218 TD (\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \203\202\222, \031\f\021\026\027\024\r\035\036\ \027\027\024\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj 0.227 Tw T* [(\f\235\017\027\022\021\036\030\024\n\036\021\030\017\017 )0.5(\(\221\026\002\035.)]TJ /Span<>> BDC ( )Tj EMC (12\). \222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\n\t\b \r\026\017\n\024\f\r\016\036\005 \r\t\016\r\035\036\027\024 \027\ \036 \002\t\035\024.)Tj 0.061 Tw 0 -1.218 TD (\211\004\017\021\t\r\026\016 \f\021\026\021\017\f\021\017\004\036\f\022\017\ \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\036 \023\024\022\ \026\026)Tj 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD (\021\036\035\016 \f\030\036\007\027\036\020\024 \007\026\r\035\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036 )Tj 0.125 Tw T* (\(\222\212 \202\025\023\), \031\027\017\r\026\030\017\026\027\021\027\t\005\ \026\027\026\035\017 \007\035\016 \007\026\027\027\024\020\024 \023\026\ \030\026)Tj 0 Tw (-)Tj T* (\n\036\021\030\026 \002\t\035 \023\030\024\r\036\007\201\027 \024\021\007\ \036\035\034\027\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (13\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 615.2279 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.173 Tw 10 0 0 10 303.3071 590.8719 Tm (\222\024\020\035\026\f\027\024 \035\017\021\036\030\026\021\031\030\027\t\ \n \017\f\021\024\004\027\017\022\026\n, \023\026\006\017\036\027\021\t \ \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 )Tj 0.351 Tw T* (\027\026\b\024\007\016\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\024\r\t\001\036\027\027\024\020\024 \030\017\ \f\022\026 \030\026\r\017\021\017\016 )Tj 0.107 Tw T* (\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 [5,6,10]. \215\030\017\004\017\027\t \036\036 \235\024\030)Tj 0 Tw (-)Tj 0.036 Tw T* (\n\017\030\024\r\026\027\017\016 \030\026\035\017\004\027\t: \021\026\022\ , \f\031\013\036\f\021\r\031\033\021 \007\026\027\027\t\036 \024)Tj /Span<>> BDC ( )Tj EMC (\r\035\017)Tj 0 Tw (-)Tj 0.03 Tw T* (\016\027\017\017 \r\024\030\026\f\021\026, \007\035\017\021\036\035\034\ \027\024\020\024 \026\027\026\n\027\036\026 \002\024\035\036\027\017 \025\ \030\024\027\026 )Tj 0.733 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\004\017\f\035\036\027\027\t\b \b\017\030\031\030\020\017\ \004\036\f\022\017\b \r\n\036\001\026\021\036\035\034\f\021\r )Tj ET q 70.866 315.086 221.102 198.837 re W n q /GS0 gs 221.1023475 0 0 199.0161231 70.8661504 314.9073454 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.767 Tw /Span<>> BDC 10 0 0 10 291.9685 315.0867 Tm ( )Tj EMC ET q 303.218 315.121 218.061 198.391 re W n q 218.0610133 0 0 198.3899535 303.2185059 315.1219483 cm /Im1 Do Q Q q 70.866 133.37 221.102 176.881 re W n q 221.1023475 0 0 176.9298952 70.8661504 133.3221611 cm /Im2 Do Q Q BT /T1_2 1 Tf /Span<>> BDC 10 0 0 10 291.9685 133.3701 Tm ( )Tj EMC ET q 303.218 133.37 221.103 176.881 re W n q 221.1023475 0 0 176.9298952 303.2185185 133.3221611 cm /Im3 Do Q Q BT /T1_2 1 Tf 0.092 Tw 9 0 0 9 70.8661 122.5701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\022\025\020\026\022\n\020 \033\031\n\020\016\020\023\027\f\027\235\ \024\203\022\025\n\023\027\032\031\026\027\023\032\022\022 \030\031)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027 \031\033\027\032\020\006\022\022: \003)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \030\020\021\f\027\025\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\031\026 \n\020\025\020\f\027 )Tj 0.04 Tw 0 -1.2 TD (\021)Tj /Span<>> BDC ( )Tj EMC (\033\031\n\031\027 \(\205\220 \003\202\033\); B)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \030\020\021\f\027\025\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\031\026 \n\020\025\020\f\027 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\021\031\f\027\021\013\200 \r\024\022\f\022\t\200 \(\205\220 \003\202\021\ \); C)Tj /Span<>> BDC ( )Tj EMC (\227 \026\020\n\024\022\026\020\f\017\025\031\027 \030\020\021\f\027\025\ \022\027 )Tj 0 Tw T* (\021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\031\026 \n\020\025\020\f\027 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\021\031\f\027\021\031\026 \024\031\n\032\020\212\027\025\022\022; D)Tj /Span<>> BDC ( )Tj EMC [(\227 \026\020\n\024\022\026\020\f\017\025\031\027 \030\020\021\f\027)0.6(\025\022\027 \021)]TJ /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\031\026 \n\020\025\020\f\027 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\n\020\213\f\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.01 Tc 0.006 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Sphincterometr)-43(y before and af)-46(ter surg)12(er)-43(y)12.1(: A)]TJ /Span<>> BDC ( )Tj EMC [(\227 av)13(erag)12(e anal resting p)46.1(ressure \(AARP\); B)]TJ /Span<>> BDC ( )Tj EMC [(\227 av)13(erag)12.1(e absolute anal sq)14(ueeze)-10( )]TJ 0 Tw T* [(p)46(ressure \(AAA)50(SP\); C)]TJ /Span<>> BDC ( )Tj EMC [(\227 maximum absolute anal sq)14(ueeze p)46(ressure \(MAA)50(SP\); D)]TJ /Span<>> BDC ( )Tj EMC [(\227 maximum absolute anal cough p)46(ressure \(MAA)26(CP\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0 72.346 TD (\020\004\206\f\t\204\004 11.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \216\032\020\030\020\006\022\t \024\023\027\033\027\025\022 \001\003\205\ \033\020\006\022\027\025\023\031\021 \030\031)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027 \031\033\027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.046 Tc 0.046 Tw 0 -1.2 TD [(T)-18.5(a)-54.3(b)-59.8(l)-57.7(e)-46( 11)-43.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.834 0 Td [( Ana)-4.5(l i)4(n)-2.9(c)2.8(o)-4(n)-0.6(t)-29.1(i)3.9(n)-2.4(e)-7(n)-2.9(c)2.8(e b)-10(ef)-13.4(o)-3(r)-2(e a)-5.1(n)-4.8(d a)-0.6(f)-50.9(t)-1.6(e)-6(r s)6.7(u)1.6(r)-1.9(g)-6.8(e)-6(r)-43.8(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 694.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 694.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 694.1118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 682.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 682.6505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 671.1893 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 671.1893 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 671.1893 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 671.1893 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 659.728 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 659.728 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 659.728 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 659.728 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 648.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 648.2667 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 648.2667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 648.2667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 411.2736 648.2667 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 106.1374 701.7465 Tm (\255\003\r\212\r\b\001 \025\032\255)Tj 14.101 0.6 Td (\031\002 \002\212\r\006\004\204\t\t)Tj 0.671 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj 12.748 1.2 Td 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(C)Tj ET 1 0.68 0 0.12 k 303.307 315.088 25.512 25.512 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 312.8565 323.8563 Tm (B)Tj ET 1 0.68 0 0.12 k 303.307 133.37 25.512 25.512 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 312.7355 142.1385 Tm (D)Tj 1 0.68 0 0.12 k /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 28.1776 56.0378 Tm (34)Tj ET endstream endobj 1571 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   "STacd !#$%&'()*123456789:ABCDEFGHIJQRUVWXYZbefghijqrstuvwxyz!1AQRS"2Ba #$%&'()*3456789:CDEFGHIJTUVWXYZbcdefghijqrstuvwxyz? <7 yЪ 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Q q 1 0 0 1 42.5197 627.2053 cm 0 0 m 283.715 0 l S Q q 1 0 0 1 326.2343 627.2053 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 627.2053 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 168.9182 706.5463 Tm (\203\004\220\003\002\006\013)Tj 23.752 0 Td (\017\016 \(95% \031\034\))Tj /T1_3 1 Tf 13.37 0.001 Td (p)Tj /T1_4 1 Tf -52.536 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \023\036\030\017\026\027\026\035\034\027\t\b \f\r\017\013\036\005 \(\035\ \036\021\))Tj 38.996 0 Td (1,12)Tj /Span<>> BDC ( )Tj EMC (\(0,95;1,31\))Tj 12.957 0 Td (0,18)Tj -51.953 -1.433 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\036\030\017\026\027\026\035\034\027\t\b \023\ \030\024\016\r\035\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036)Tj 1.063 -1.2 Td (\212\026)Tj T* (\203\036\021)Tj 40.852 1.2 Td (1)Tj -2.919 -1.2 Td (0,89)Tj /Span<>> BDC ( )Tj EMC (\(0,24;3,32\))Tj 12.957 2.4 Td (0,86)Tj -51.953 -3.833 Td (\200\f\022\030\t\021\017\036 \023\026\030\026\023\030\024\022\021\017\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \(\022\024\035-\r\024\))Tj 38.996 0 Td (1,45)Tj /Span<>> BDC ( )Tj EMC (\(0,68;3,12\))Tj 12.957 0 Td (0,34)Tj -51.953 -1.433 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\036\030\017\026\027\026\035\034\027\t\b \023\ \030\024\016\r\035\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \(\022\024\035-\r\024\))Tj 38.996 0 Td (1,66)Tj /Span<>> BDC ( )Tj EMC (\(0,71;3,87\))Tj 12.957 0 Td (0,24)Tj -51.953 -1.433 Td (\025\024\035\017\004\036\f\021\r\024 \f\r\017\013\036\005)Tj 38.996 0 Td (2,05)Tj /Span<>> BDC ( )Tj EMC (\(0,88;4,77\))Tj 12.707 0 Td (0,096)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5197 610.486 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\031\n\020\016\020\023\027\f\022 \024\203\022\025\n\023\027\032\031\ \026\027\023\032\022\022 \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021, \021\n\f\005\007\027\025\025\013\200\ \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.002 Tc -0.002 Tw 3.323 0 Td [( S)11.1(p)0.9(h)3.7(i)5.9(n)-0.9(c)-30.4(te)-3.9(ro)-2(m)-3.3(e)-6.6(t)-7.6(r)-41.8(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 595.184 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 574.3648 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 133.4783 595.184 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 133.4783 574.3648 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 235.5256 595.184 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 574.3648 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 595.184 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 574.3648 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 439.6201 595.184 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 574.3648 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 574.3648 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 574.1148 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 553.3035 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 133.4783 574.1148 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 133.4783 553.3035 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 235.5256 574.1148 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 553.3035 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 574.1148 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 553.3035 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 574.1148 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 553.3035 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 553.3035 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 553.0535 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 532.2422 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 133.4783 553.0535 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 133.4783 532.2422 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 235.5256 553.0535 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 532.2422 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 553.0535 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 532.2422 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 553.0535 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 532.2422 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 532.2422 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 531.9922 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 511.181 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 133.4783 531.9922 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 133.4783 511.181 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 235.5256 531.9922 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 511.181 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 531.9922 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 511.181 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 531.9922 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 511.181 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 511.181 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 510.931 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 490.1197 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 133.4783 510.931 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 133.4783 490.1197 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 235.5256 510.931 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 490.1197 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 510.931 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 490.1197 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 439.6201 510.931 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 490.1197 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 490.1197 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 489.8697 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 489.8697 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 489.8697 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 489.8697 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 439.6201 489.8697 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 68.4843 581.7495 Tm (\200\004\006\004\214\r\003\006\013)Tj 11.573 0.6 Td (\031\002 \002\212\r\006\004\204\t\t,)Tj -2.037 -1.2 Td (Me \(Q1;Q3\) \(min\232max\))Tj 14.039 1.2 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t,)Tj -1.283 -1.2 Td (Me \(Q1;Q3\) \(min\232max\))Tj 16.327 0.6 Td (\025\002\006\214\004)Tj /T1_3 1 Tf 9.737 0 Td (p)Tj /T1_1 1 Tf (-value)Tj /T1_4 1 Tf -51.215 -2.033 Td (\222\212 \202\025\023, N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150)Tj 13.456 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(36;41\) \(18\22676\))Tj 12.413 0 Td (37,5)Tj /Span<>> BDC ( )Tj EMC (\(32;39\) \(18\22655\))Tj 14.196 0 Td (41\22663)Tj /Span<>> BDC ( )Tj EMC (\(\240\036\027.\))Tj 0.011 -1.2 Td (43\22661)Tj /Span<>> BDC ( )Tj EMC (\(\204\031\032.\))Tj 12.469 1.2 Td (1)Tj -52.545 -2.633 Td (\204\212 \202\025\r, N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150)Tj 12.456 0 Td (133)Tj /Span<>> BDC ( )Tj EMC (\(109;155\) \(39\226312\))Tj 12.413 0 Td (138,5)Tj /Span<>> BDC ( )Tj EMC (\(105;170\) \(44\226279\))Tj 14.011 0 Td (110,0\226178,0)Tj /Span<>> BDC ( )Tj EMC (\(\240\036\027.\))Tj 0.696 -1.2 Td (121\226227)Tj /Span<>> BDC ( )Tj EMC (\(\204\031\032.\))Tj 12.376 1.2 Td (0,26)Tj -51.953 -2.633 Td (\222\212 \202\025\r, N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (39)Tj 13.206 0 Td (84)Tj /Span<>> BDC ( )Tj EMC (\(69;94\) \(37\226132\))Tj 12.756 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(65;96\) \(35\226159\))Tj 13.854 0 Td (88\226146)Tj /Span<>> BDC ( )Tj EMC (\(\240\036\027.\))Tj -0.239 -1.2 Td (106\226190)Tj /Span<>> BDC ( )Tj EMC (\(\204\031\032.\))Tj 12.376 1.2 Td (0,18)Tj -51.953 -2.633 Td (\204\212 \202\025\022, N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (75)Tj 12.956 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(67;108\) \(10\226174\))Tj 12.756 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(60;115\) \(41\226260\))Tj 14.104 0 Td (76\226126)Tj /Span<>> BDC ( )Tj EMC (\(\240\036\027.\))Tj 0.011 -1.2 Td (45\226175)Tj /Span<>> BDC ( )Tj EMC (\(\204\031\032.\))Tj 12.376 1.2 Td (0,4)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5197 473.1504 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \232\020\024\023\031\023\020 \001\003\205 \033\031 \030\020\025\025\013\ \026 \024\203\022\025\n\023\031\032\031\026\027\023\032\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.329 0 Td [( T)-6.4(h)-2.4(e i)4(n)-2.9(c)-30.1(i)-1.4(d)-5.3(e)-7(n)-2.9(c)2.8(e o)4.1(f o)-2.3(b)0.8(j)-3.7(e)-10.9(c)-32.4(t)-29.1(i)-2.9(v)2.4(e A)-18(I)]TJ ET /GS2 gs q 1 0 0 1 42.5197 457.8484 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 446.3792 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4783 457.8484 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 457.8484 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 446.6292 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 457.8484 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6043 457.8484 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 446.6292 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 446.3792 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 435.16 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 223.937 446.3792 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 224.187 435.16 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 446.3792 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8957 435.16 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 435.16 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 435.16 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5197 434.91 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 423.4487 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 434.91 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 423.6987 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 434.91 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 423.6987 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 434.91 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 423.6987 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 434.91 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 423.6987 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 423.4487 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 412.2374 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 423.4487 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 412.2374 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 423.4487 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 412.2374 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 423.4487 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8957 412.2374 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 412.2374 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 412.2374 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 411.9874 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 411.9874 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 411.9874 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8957 411.9874 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6043 411.9874 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 102.8388 443.4792 Tm (\017\206\233\r\220\003\t\b\004\235 \025\032\255)Tj 20.745 0.717 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj /T1_3 1 Tf 21.189 -0.717 Td (p)Tj /T1_1 1 Tf (-value)Tj -21.634 -0.717 Td (\031\004)Tj 11.105 0 Td (\025\r\003)Tj /T1_4 1 Tf -38.56 -1.433 Td (\212\024 \024\023\036\030\026\006\017\017)Tj T* (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj 16.124 1.2 Td (\212\026)Tj 11.118 0 Td (118)Tj 11.839 0 Td (2)Tj 10.246 0 Td (0,0004)Tj -33.402 -1.433 Td (\203\036\021)Tj 11.568 0 Td (19)Tj 11.339 0 Td (11)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5197 395.2681 Tm (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \033\031\n\020\016\020\023\027\f\t \205\220\ \003\202\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.076 Tc 0.076 Tw T* [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.25 0 Td [( A)4.1(v)2.3(e)-6(r)3.3(a)-5.1(g)-6.8(e a)-5.1(na)-4.5(l r)-2(e)-21.9(s)-14.9(t)-29(i)3.9(n)-0.6(g p)-2.8(r)-2(e)-22(s)-10.5(s)6.7(u)1.6(r)-2(e \()61(A)-18.4(A)10(R)6.7(P)57.1(\))]TJ ET /GS2 gs q 1 0 0 1 42.5197 379.9662 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 368.4969 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4783 379.9662 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 379.9662 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 368.7469 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8956 379.9662 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6043 379.9662 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 368.7469 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 368.4969 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7697 357.2777 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 223.937 368.4969 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 224.187 357.2777 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8956 368.4969 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8956 357.2777 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6043 357.2777 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 357.2777 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5197 357.0277 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7697 345.5664 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 357.0277 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 345.8164 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 357.0277 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 345.8164 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 357.0277 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8956 345.8164 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 357.0277 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6043 345.8164 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 345.5664 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 334.3552 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 345.5664 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 334.3552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 345.5664 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 334.3552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 345.5664 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8956 334.3552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6043 334.3552 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 334.3552 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 334.1052 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 334.1052 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.187 334.1052 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8956 334.1052 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6043 334.1052 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 121.4346 365.597 Tm (\255\031 \032\021\212)Tj 18.421 0.717 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj /T1_3 1 Tf 21.189 -0.717 Td (p)Tj /T1_1 1 Tf (-value)Tj -22.305 -0.717 Td (\025\t\202\r)Tj 11.151 0 Td (\025\002\006\214\004)Tj /T1_4 1 Tf -37.935 -1.433 Td (\212\024 \024\023\036\030\026\006\017\017)Tj T* (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj 15.527 1.2 Td (\203\017\032\036)Tj 11.716 0 Td (111)Tj 11.839 0 Td (5)Tj 10.246 0 Td (0,0003)Tj -33.997 -1.433 Td (\203\024\030\n\026)Tj 12.162 0 Td (26)Tj 11.589 0 Td (8)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5196 317.3859 Tm (\020\004\206\f\t\204\004 8.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \033\031\n\020\016\020\023\027\f\t \205\220\ \003\202\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 8)-39.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.339 0 Td [( A)1.6(b)2(s)0.5(o)-5.3(lu)-4.8(t)-1.6(e a)-5.1(na)-4.5(l s)1.5(q)-2.9(u)-3.2(e)-10.4(e)-21(z)7.9(e p)-2.8(r)-2(e)-22(s)-10.5(s)6.7(u)1.6(r)-1.9(e \()60.9(A)-18.4(A)-18.4(A)-5.6(S)17(P)57.1(\))]TJ ET /GS2 gs q 1 0 0 1 42.5196 302.0839 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7696 290.6147 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4783 302.0839 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 302.0839 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 290.8647 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8956 302.0839 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6042 302.0839 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6042 290.8647 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.3129 290.6147 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7696 279.3954 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 223.9369 290.6147 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 224.1869 279.3954 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8956 290.6147 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8956 279.3954 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6042 279.3954 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.3129 279.3954 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5196 279.1454 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7696 267.6842 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4783 279.1454 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4783 267.9342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1869 279.1454 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 267.9342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 279.1454 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8956 267.9342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6042 279.1454 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6042 267.9342 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3129 267.6842 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7696 256.4729 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2283 267.6842 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 256.4729 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1869 267.6842 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 256.4729 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8956 267.6842 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8956 256.4729 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6042 256.4729 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3129 256.4729 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5196 256.2229 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4783 256.2229 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 256.2229 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8956 256.2229 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6042 256.2229 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 121.4985 287.7147 Tm (\255\031 \032\021)Tj 18.691 0.717 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (39\))Tj /T1_3 1 Tf 20.911 -0.717 Td (p)Tj /T1_1 1 Tf (-value)Tj -22.305 -0.717 Td (\025\t\202\r)Tj 11.151 0 Td (\025\002\006\214\004)Tj /T1_4 1 Tf -37.935 -1.433 Td (\212\024 \024\023\036\030\026\006\017\017)Tj T* (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (39\))Tj 15.527 1.2 Td (\203\017\032\036)Tj 11.716 0 Td (229)Tj 11.839 0 Td (2)Tj 10.996 0 Td (0,2)Tj -34.747 -1.433 Td (\203\024\030\n\026)Tj 12.412 0 Td (7)Tj 11.339 0 Td (8)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5195 239.5036 Tm (\020\004\206\f\t\204\004 9.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \033\031\n\020\016\020\023\027\f\t \215\220\ \003\202\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 9.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.299 0 Td [( M)0.8(a)-21(x)-30(i)3.9(m)1(u)0.6(m a)-0.9(b)2(s)0.5(o)-5.3(lu)-4.8(t)-1.6(e a)-5.1(na)-4.5(l s)1.5(q)-3(u)-3.1(e)-10.4(e)-21(z)7.9(e p)-2.8(r)-2(e)-22(s)-10.5(s)6.7(u)1.6(r)-1.9(e \()38.1(M)5.3(A)-18.4(A)-5.6(S)17(P)57.1(\))]TJ ET /GS2 gs q 1 0 0 1 42.5195 224.2016 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7695 212.7324 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4782 224.2016 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 224.2016 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 212.9824 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8955 224.2016 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6042 224.2016 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6042 212.9824 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.3128 212.7324 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7695 201.5132 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 223.9369 212.7324 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 224.1869 201.5132 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8955 212.7324 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8955 201.5132 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6042 201.5132 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.3128 201.5132 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5195 201.2632 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7695 189.8019 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4782 201.2632 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4782 190.0519 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1869 201.2632 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 190.0519 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8955 201.2632 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8955 190.0519 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6042 201.2632 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6042 190.0519 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3128 189.8019 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7695 178.5906 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2282 189.8019 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4782 178.5906 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1869 189.8019 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 178.5906 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8955 189.8019 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8955 178.5906 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6042 178.5906 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3128 178.5906 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5195 178.3406 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4782 178.3406 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1869 178.3406 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8955 178.3406 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6042 178.3406 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 120.6624 209.8324 Tm (\215\031 \032\021)Tj 18.517 0.717 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj /T1_3 1 Tf 21.189 -0.717 Td (p)Tj /T1_1 1 Tf (-value)Tj -22.305 -0.717 Td (\025\t\202\r)Tj 11.151 0 Td (\025\002\006\214\004)Tj /T1_4 1 Tf -37.935 -1.433 Td (\212\024 \024\023\036\030\026\006\017\017 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150\))Tj 15.527 0 Td (\203\017\032\036)Tj 11.966 0 Td (32)Tj 11.339 0 Td (18)Tj 11.246 0 Td (1,0)Tj -34.747 -1.433 Td (\203\024\030\n\026)Tj 12.162 0 Td (17)Tj 11.339 0 Td (83)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5195 161.6213 Tm (\020\004\206\f\t\204\004 10.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \033\031\n\020\016\020\023\027\f\t \215\220\ \003\202\n)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-5(0)-29.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.863 0 Td [( M)0.8(a)-21(x)-30(i)3.9(m)1(u)0.6(m a)-0.9(b)2(s)0.5(o)-5.3(lu)-4.8(t)-1.6(e a)-5.1(na)-4.5(l c)2.9(o)-3.4(u)-2.3(g)-2.4(h p)-2.8(r)-2(e)-22(s)-10.5(s)6.7(u)1.6(r)-2(e \()38.2(M)5.3(A)-18.4(A)10.4(C)4.9(P)57.1(\))]TJ ET /GS2 gs q 1 0 0 1 42.5195 146.3193 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7695 134.8501 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 133.4781 146.3193 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1868 146.3193 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1868 135.1001 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8954 146.3193 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6041 146.3193 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6041 135.1001 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.3128 134.8501 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.7695 123.6309 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 223.9368 134.8501 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 224.1868 123.6309 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8954 134.8501 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8954 123.6309 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6041 123.6309 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.3128 123.6309 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 42.5195 123.3809 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 42.7695 111.9196 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.4781 123.3809 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 133.4781 112.1696 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1868 123.3809 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1868 112.1696 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8954 123.3809 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8954 112.1696 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6041 123.3809 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 405.6041 112.1696 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3128 111.9196 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7695 100.7083 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 133.2281 111.9196 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4781 100.7083 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.1868 111.9196 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1868 100.7083 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8954 111.9196 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 314.8954 100.7083 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6041 100.7083 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.3128 100.7083 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5195 100.4583 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 133.4781 100.4583 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 224.1868 100.4583 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 314.8954 100.4583 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 405.6041 100.4583 cm 0 0 m 90.959 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 120.7104 131.9502 Tm (\215\031 \032\021\220)Tj 18.789 0.717 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (75\))Tj /T1_3 1 Tf 20.911 -0.717 Td (p)Tj /T1_1 1 Tf (-value)Tj -22.305 -0.717 Td (\025\t\202\r)Tj 11.151 0 Td (\025\002\006\214\004)Tj /T1_4 1 Tf -37.935 -1.433 Td (\212\024 \024\023\036\030\026\006\017\017)Tj T* (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (75\))Tj 15.527 1.2 Td (\203\017\032\036)Tj 11.966 0 Td (10)Tj 11.589 0 Td (7)Tj 10.996 0 Td (0,6)Tj -34.747 -1.433 Td (\203\024\030\n\026)Tj 12.162 0 Td (10)Tj 11.339 0 Td (48)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8019 56.0378 Tm (33)Tj ET endstream endobj 1567 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.134 Tw 10 0 0 10 70.8661 724.8299 Tm (\215\030\017 \023\030\024\r\036\007\036\027\017\017 \n\027\024\020\024\235\ \026\022\021\024\030\027\024\020\024 \026\027\026\035\017\026 \027\036 \ \002\t\035\024 )Tj 0.141 Tw 0 -1.218 TD (\023\024\007\021\r\036\030\032\007\036\027\024 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\026\004\017\n\024\020\024 \r\035\017\016\027\017\ \016 \027\017 )Tj 0.042 Tw T* (\024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\023\024\035\026\020\026\036\n\t\b \235\026\022\021\024\030\ \024\r \030\017\f\022\026 \030\026\r\017\021\017\016 )Tj 0 Tw T* (\022\035\017\027\017\004\036\f\022\024\005 \203\202\222 \(\221\026\002\035\ .)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.079 Tw T* (\202\027\026\035\017\017\030\031\016 \023\024\022\026\026\021\036\035\017\ \f\235\017\027\022\021\036\030\024\n\036\021\030\017\017, \024\021\n\036\ \004\036\027\024, )Tj 0.004 Tw T* (\004\021\024 \023\026\030\026\n\036\021\030\t \f\030\036\007\027\036\020\ \024 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 )Tj 0.075 Tw 0 -1.218 TD (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017 \r\024\035\036\r\t\b \031\f\017\035\017\016\b )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj -0.029 Tw 0 -1.218 TD (\002\t\035\017 \027\036\f\022\024\035\034\022\024 \f\027\017\032\036\027\ \t \024\021\027\024\f\017\021\036\035\034\027\024 \030\036\235\036\030\036\ \027\f\027\t\b )Tj 0.101 Tw T* (\027\026\004\036\027\017\005 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\). \215\024\022\026\026\021\036\035\017 \n\026\022\f\017\n\026\035\034\ \027\024\020\024 \007\026\r)Tj 0 Tw (-)Tj 0.02 Tw T* (\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n \f\024\022\030\026\013\036\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \022\026\001\035\036 \027\026\b\024\007\017)Tj 0 Tw (-)Tj T* (\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \027\024\030\n\t.)Tj 0.816 Tw T* [(\203\202\222, \r\t\016\r\035\036\027\027\026\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\235\017\027\022\021\036\030\024\n\036\021\030\017\017, )0.5(\002\t\035\026 )]TJ 0.02 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (120/150 \(80%\) \023\026\006\017\036\027\021\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031 137/150 )Tj 0.059 Tw 0 -1.218 TD (\(91%\) \023\024\f\035\036 \024\023\036\030\026\006\017\017. \215\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\f\024\r\024\022\031\023\027\024\005 \024\006\036\027\022\036 \r\f\036\b\ )Tj 0.082 Tw 0 -1.218 TD (\017\n\036\033\013\017\b\f\016 \023\024\022\026\026\021\036\035\036\005\ \f\235\017\027\022\021\036\030\024\n\036\021\030\017\017 \024\021\n\036\ \004\036\027\024 )Tj -0.027 Tw T* (\007\024\f\021\024\r\036\030\027\024\036 \031\r\036\035\017\004\036\027\017\ \036 \022\024\035\017\004\036\f\021\r\026 \023\026\006\017\036\027\021\024\ \r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202\222 )Tj 0.19 Tw T* [(\023\024\f\035\036 )0.5(\023\030\024\r\036\007\036\027\027\024\020\024 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026 )]TJ 0 Tw T* (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0004\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.236 Tw T* (\222\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036 \(\222\212 )Tj 0.041 Tw T* (\202\025\023\) \017\f\b\024\007\027\024 \002\t\035\024 \f\027\017\032\036\ \027\024 \031)Tj /Span<>> BDC ( )Tj EMC (116 \(77%\), \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.213 Tw T* (\030\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (137 \(91%\), \004\021\024 \f\r\017\007\036\021\036\035\034\f\021\r\031\036\ \021 \024)Tj /Span<>> BDC ( )Tj EMC (\f\027\017)Tj 0 Tw (-)Tj 0.576 Tw T* (\032\036\027\017\017 \007\026\027\027\024\020\024 \023\026\030\026\n\036\ \021\030\026 \023\024\f\035\036 \r\n\036\001\026\021\036\035\034\f\021\r\ \026 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.108 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0003\). \003\027\026\004\017\n\024\020\024 \017\n\036\027\036\027\017\ \016 \024\f\021\026\035\034\027\t\b \023\024\022\026)Tj 0 Tw (-)Tj T* (\026\021\036\035\036\005 \027\036 \r\t\016\r\035\036\027\024 \(\221\026\ \002\035.)Tj /Span<>> BDC ( )Tj EMC (7\22610\), \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.023 Tw T* (\222\024\020\035\026\f\027\024 \023\024\035\031\004\036\027\027\t\n \007\ \026\027\027\t\n, \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 \024\023\036\030\026)Tj 0 Tw (-)Tj 0.12 Tw T* (\006\017\017 \203\202\222 1 \f\021\036\023\036\027\017 \031\f\021\026\027\ \024\r\035\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (78/150 \(52%\) \023\026)Tj 0 Tw (-)Tj 0.04 Tw T* (\006\017\036\027\021\024\r, \203\202\222 2 \f\021\036\023\036\027\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (38/150 \(25%\), \026)Tj /Span<>> BDC ( )Tj EMC (\031 4/150 )Tj -0.006 Tw T* (\(3%\))Tj /Span<>> BDC ( )Tj EMC 2.226 0 Td [(\227 \203\202\222 )0.5(3 \f\021\036\023\036\027\017 )0.5(\(\221\026\002\035.)]TJ /Span<>> BDC ( )Tj EMC 10.117 0 Td [(11\). )0.5(\222\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.077 Tw -12.342 -1.218 Td (\004\017\n\024\036 \031\r\036\035\017\004\036\027\017\036 \004\026\f\021\ \024\021\t \203\202\222 \023\030\024\017\f\b\024\007\017\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.1 Tw T* (\023\036 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\024 \024\021\f\031\021\f\021\r\031\033\013\017\n\017\ \016\r\035\036\027\017\016\n\017 )Tj 0.297 Tw T* (\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026)Tj 0 Tw (-)Tj T* (\021\036\035\034\f\021\r\026 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\).)Tj ET q 70.866 133.37 221.102 189.292 re W n q /GS0 gs 221.1023475 0 0 189.4134213 70.8661351 133.2494702 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.093 Tw 9 0 0 9 70.8661 122.5701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \220\022\025\020\026\022\n\020 \022\016\026\027\025\027\025\022\235 \n\031\ \f\022\007\027\024\023\021\020 \240\020\f\f\031\021 \021)Tj /Span<>> BDC ( )Tj EMC (\024\031)Tj 0 Tw (-)Tj 0.147 Tw 0 -1.2 TD (\031\023\021\027\023\024\023\021\022\022 \024\031 \213\n\020\f\031\235 W\ exner \030\031)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027 \031\033\027\032\020\023\022\021\025\031\b\031 )Tj 0 Tw T* (\021\026\027\213\020\023\027\f\017\024\023\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw T* [(F)-16(igure )0.5(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Dynamics )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(W)30(e)-15(xner score chang)12(es before )0.5(and )0.5(af)-46(ter )]TJ 0 Tw T* [(surg)12(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.16 Tw 25.827 72.346 Td (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \210\025\022\021\020\032\022\020\025\023\025\013\235 \020\025\020\f\022\ \016 \203\020\n\023\031\032\031\021, \021\f\022\t\005\212\022\200 )Tj 0 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\027 \001\003\205 \033\031 \n\f\022\025\022\007\ \027\024\n\022\026 \030\020\025\025\013\026, \033\031\024\f\027 \031\033\ \027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.159 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.132 Tw 3.45 0 Td [( U)7.5(n)1.7(i)-2.9(v)6.3(a)-4.2(r)-39(i)1.5(a)-9.2(t)-1.6(e a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.4(i)6.6(s o)4(f p)-6.3(a)-4.2(r)3.4(a)-5.1(m)-5.3(e)-8.6(t)-1.6(e)-6(r)-14.9(s a)-0.6(f)-42.4(f)-13.4(e)-10.9(c)-32.4(t)-29.1(i)3.9(n)-0.6(g c)-1.1(li)3.9(n)1.7(i)-1.7(c)3.2(a)-4.5(l )]TJ 0 Tw -3.45 -1.2 Td [(A)-18(I a)-0.6(f)-50.8(t)-1.6(e)-6(r s)6.7(u)1.6(r)-2(g)-6.8(e)-6(r)-43.8(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 693.581 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 680.4909 cm 0 0 m 0 12.84 l S Q q 1 0 0 1 433.9508 693.581 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 680.4909 cm 0 0 m 0 12.84 l S Q q 1 0 0 1 490.6437 693.581 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 680.4909 cm 0 0 m 0 12.84 l S Q q 1 0 0 1 524.6594 680.4909 cm 0 0 m 0 12.84 l S Q q 1 0 0 1 303.3071 680.2409 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 667.1588 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 680.2409 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 667.1588 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 680.2409 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 667.1588 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 667.1588 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 666.9088 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 634.6266 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 666.9088 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 634.6266 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 666.9088 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 634.6266 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 634.6266 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 634.3766 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 621.2944 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 634.3766 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 621.2944 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 634.3766 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 621.2944 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 621.2944 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 621.0444 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 588.7623 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 621.0444 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 588.7623 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 621.0444 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 588.7623 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 588.7623 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 588.5123 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 556.2302 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 588.5123 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 556.2302 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 588.5123 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 556.2302 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 556.2302 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 555.9802 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 523.698 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 555.9802 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 523.698 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 555.9802 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 523.698 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 523.698 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 523.448 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 510.3658 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 523.448 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 510.3658 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 523.448 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 510.3658 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 510.3658 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 510.1158 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 497.0337 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 510.1158 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 497.0337 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 510.1158 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 497.0337 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 497.0337 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 496.7837 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 454.9016 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 433.9508 496.7837 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 454.9016 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 490.6437 496.7837 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 454.9016 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 524.6594 454.9016 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 303.3071 454.6516 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 422.3694 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 454.6516 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 422.3694 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 454.6516 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 422.3694 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 422.3694 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 422.1194 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 409.0373 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 422.1194 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 409.0373 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 422.1194 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 409.0373 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 409.0373 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 408.7873 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 376.5051 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 408.7873 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 376.5051 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 408.7873 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 376.5051 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 376.5051 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 376.2551 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 334.373 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 433.9508 376.2551 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 334.373 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 490.6437 376.2551 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 334.373 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 524.6594 334.373 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 303.3071 334.123 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 311.4408 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 433.9508 334.123 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 311.4408 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 490.6437 334.123 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 311.4408 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 524.6594 311.4408 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 303.3071 311.1908 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 288.5087 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 433.9508 311.1908 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 288.5087 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 490.6437 311.1908 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 288.5087 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 524.6594 288.5087 cm 0 0 m 0 22.432 l S Q q 1 0 0 1 303.3071 288.2587 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 255.9765 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 288.2587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 255.9765 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 288.2587 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 255.9765 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 255.9765 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 255.7265 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 223.4444 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 255.7265 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 223.4444 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 255.7265 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 223.4444 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 223.4444 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 223.1944 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 210.1122 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 223.1944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 210.1122 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 223.1944 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 210.1122 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 210.1122 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 209.8622 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 167.98 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 433.9508 209.8622 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 167.98 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 490.6437 209.8622 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 167.98 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 524.6594 167.98 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 303.3071 167.73 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 135.4479 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 433.9508 167.73 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 135.4479 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 490.6437 167.73 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 135.4479 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 524.6594 135.4479 cm 0 0 m 0 32.032 l S Q q 1 0 0 1 303.3071 135.1979 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 122.1158 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 433.9508 135.1979 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 122.1158 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 490.6437 135.1979 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 122.1158 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 524.6594 122.1158 cm 0 0 m 0 12.832 l S Q q 1 0 0 1 303.3071 121.8658 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 303.5571 79.9836 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 433.9508 121.8658 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 433.9508 79.9836 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 490.6437 121.8658 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 79.9836 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 524.6594 79.9836 cm 0 0 m 0 41.632 l S Q q 1 0 0 1 303.3071 79.7336 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 433.9508 79.7336 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 490.6437 79.7336 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 353.1702 684.011 Tm (\203\004\220\003\002\006\013)Tj 10.641 0 Td (\017\016 \(95% \031\034\))Tj /T1_3 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0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\002\t\r\n\025\t\017\020\200\t\217\004 \005\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 \020\004\225\004\t\n\213 )]TJ 0 -1 TD [(\224\005\213\024\025\r\n\204\004\225\t\217\220 \016\b\n\234\004\221 \002\ \022\224\017\n\004\t\026)11(\025\b \016\022\255\025\020\004\212\t\200\206 \037)19.9(\005\025\t\017)]TJ 42.41 1 Td [(Functional r)31(esults of\022sur)31.1(gical tr)31(eatment of\022anal )]TJ 2.765 -1 Td [(f)-21(istulas in patients with Cr)20(ohn\236)63(s disease)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.012 Tc 0.593 Tw 10 0 0 10 42.5197 724.8299 Tm [(\035\024\022\026\035\017\026\006\017\033 \f\r\017\013\036\r\024\020\024\ \b\024\007\026, \036\020\024 \030\026\f\023\024\035\024\032\036\027\017\ \036)-12( )]TJ 0.229 Tw 0 -1.218 TD (\024\021\027\024\f\017\021\036\035\034\027\024 \027\026\030\031\032\027\024\ \020\024 \f\235\017\027\022\021\036\030\026, \027\026\035\017\004\017\036\ \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.17 Tw T* (\023\024\035\024\032\036\027\017\036 \026\021\036\022\024\r. \025\035\017\ \027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036\027\017\016 \026\ \027\026\035\034)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.191 Tw T* (\027\024\005 \017\027\022\024\027\021\017\027\036\027\006\017\017 \002\t\ \035\017 \024\006\036\027\036\027\t \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner)-12( )]TJ 0.014 Tw T* (\(0)Tj /Span<>> BDC ( )Tj EMC 1.08 0 Td (\002\026\035\035\024\r)Tj /Span<>> BDC ( )Tj EMC 3.055 0 Td [(\227 )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\022\035\017\027\017\004\036\f\022\024\005 )0.5(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017)-12( )]TJ 0.115 Tw -4.136 -1.218 Td (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026,\ 20 \002\026\035\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\035\027\024\036 \027\036\007\036\030\032\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.079 Tw 0 -1.218 TD (\027\017\036\). \203\026\035\017\004\017\036 \203\202\222 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \031\f\021\026\027\026\r\035\017\r\026\035\ \017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc -0.006 Tw 0 -1.218 TD (\035\017\004\017\017 2-\b \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \002\026\035\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner. \212\035\016 \024\002\255\036\022)]TJ 0 Tc 0 Tw (-)Tj -0.012 Tc 0.05 Tw T* [(\021\017\r\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \235\ \031\027\022\006\017\017 \003\202\215\025 \023\026\006\017\036\027\021\026\ \n \002\t\035\026)-12( )]TJ 0.209 Tw T* (\r\t\023\024\035\027\036\027\026 \f\235\017\027\022\021\036\030\024\n\036\ \021\030\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\024\005 \023\024\022\026\026\021\036\035\036\005)-12( )]TJ -0.042 Tw T* (\f\030\036\007\027\036\020\024 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\022\024\036 \(\222\212 \202\025\023\))-12( )]TJ 0.043 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\024\020\024 \007\026\r\035\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.131 Tw 0 -1.218 TD [(\035\036\r\024\n )0.6(\f\024\022\030\026\013\036\027\017\017 )0.5(\(\204\212 )0.5(\202\025\r\). )0.5(\200\r\017\007\031 )0.5(\030\036\021\030\024\f\023\036\022\021\017\r\027\024)]TJ 0 Tc 0 Tw (-)Tj -0.012 Tc 0.197 Tw 0 -1.218 TD (\020\024 \b\026\030\026\022\021\036\030\026 \017\f\f\035\036\007\024\r\026\ \027\017\016, \035\017\001\034 \031)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\017 \023\026\006\017\036\027\021\024\r)-12( )]TJ 0.138 Tw 0 -1.218 TD (\002\t\035\017 \023\030\024\026\027\026\035\017\017\030\024\r\026\027\t\ \023\024\022\026\026\021\036\035\017 \f\030\036\007\027\036\020\024 \007\ \026\r\035\036)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.052 Tw T* (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\024\035\036\r\t\b \031\f\017\035\017\016\b \(\222\212 \202\025\r\))-12( )]TJ 0.013 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.739 0 Td [(\n\026\022\f\017\n\026\035\034\027\024\036 )0.6(\007\026\r\035\036\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.669 0 Td [(\026\027\026\035\034\027\024\n )0.5(\022\026\027\026\035\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.791 0 Td (\022\026\001)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.079 Tw -20.2 -1.218 Td [(\035\036 )0.5(\(\204\212 \202\025\022\). )0.5(\206\030\026\007\026\006\017\016 )0.5(\f\021\036\023\036\027\017 \203\202\222 \031)]TJ /Span<>> BDC ( )Tj EMC 15.778 0 Td (\023\026\006\017\036\027\021\024\r \023\030\024)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc -0.04 Tw -15.778 -1.218 Td (\r\036\007\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\f\024\024\021\r\036\021\f\021\r\017\017 \f\024 \027\026\004\036\027\017\ \016\n\017, \031\f\021\026\027\024\r\035\036\027\027\t\n\017)-12( )]TJ 0.156 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC [(\217\t\032\017\b\273)-12( )]TJ 0.052 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017 [9]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\026\027\026\035\017\036 \007\026\027\027\t\b, \027\026\004\036\027\017\ \016)-12( )]TJ 0.447 Tw T* [(\023\024\022\026\026\021\036\035\036\005 )0.6(\f\235\017\027\022\021\036\030\024\n\036\021\030\017\017, )0.5(\023\030\036\r\t\001\026\033\013\017\036 )0.5(\027\024\030)]TJ 0 Tc 0 Tw (-)Tj -0.012 Tc -0.002 Tw T* (\n\026\035\034\027\t\036, \002\t\035\017 \024\021\027\036\f\036\027\t \022\ )Tj /Span<>> BDC ( )Tj EMC [(\027\024\030\n\036. \210\002\255\036\n \024\023\036\030\026\021\017\r\027\ \024\020\024)-12( )]TJ 0.255 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026 \002\t\035 \024\023\030\036\ \007\036\035\036\027 \017\027\007\017\r\017\007\031\026\035\034\027\024 \ \r)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.148 Tw T* [(\r\017\f\017\n\024\f\021\017 \024\021 \022\035\017\027\017\004\036\f\022\ \024\005 \f\017\021\031\026\006\017\017. \221\026\022\017\n \024\002\030\ \026\024\n,)-12( )]TJ 0.264 Tw T* [(\023\024\f\035\036 \024\002\f\035\036\007\024\r\026\027\017\005 75/150 \(\ 50%\) \023\026\006\017\036\027\021\026\n \002\t\035\024)-12( )]TJ 0.15 Tw T* (\r\t\023\024\035\027\036\027\024 \017\f\f\036\004\036\027\017\036 \f\r\017\ \013\026, \r\f\022\030\t\021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.186 Tw T* (\027\017\036 \026\021\036\022\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\017\036\n \007\030\036\027\017\030\031\033\ \013\036\005 \035\026\021\036\022\f\027\024\005)-12( )]TJ 0.017 Tw T* (\035\017\020\026\021\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC 4.61 0 Td (\022\026\004\036\f\021\r\036 \023\036\030\r\024\020\024 \220\021\026\023\ \026 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.052 Tw -4.61 -1.218 Td (\004\036\027\017\016. \212\030\031\020\024\005 \023\024\035\024\r\017\027\ \036 \023\026\006\017\036\027\021\024\r \(75/150\))Tj /Span<>> BDC ( )Tj EMC (\227 \024\007\027\024)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.471 Tw T* [(\220\021\026\023\027\t\036 \030\026\007\017\022\026\035\034\027\t\036 \024\ \023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034\f\021\ \r\026,)-12( )]TJ 0.359 Tw T* [(\f\030\036\007\017 \022\024\021\024\030\t\b: \017\f\f\036\004\036\027\017\ \036 \f\r\017\013\026/\017\f\f\036\004\036\027\017\036 \f\r\017\013\026)-12( )]TJ 0.1 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\f\022\030\t\021\017\036 \026\021\201\022\024\r \(44%)Tj /Span<>> BDC ( )Tj EMC (\227 66/150\), \027\017\r\036\007\036\027\017\036 \035\024)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc -0.016 Tw T* (\f\022\031\021\026 \f\021\036\027\022\017 \023\030\016\n\024\005 \022\017\ \001\022\017 \(2%)Tj /Span<>> BDC ( )Tj EMC [(\227 3/150\), \035\017\022\r\017\007\026\006\017\016)-12( )]TJ 0.148 Tw T* [(\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\020\024 )0.5(\f\r\017\013\026 )0.5(\017\027\r\026\020\017\027\026\006\017\024\027\027\t\n )0.5(\n\036\021\024\007\024\n)-12.1( )]TJ 0.07 Tw T* (\(2%)Tj /Span<>> BDC ( )Tj EMC (\227 3/150\) \017)Tj /Span<>> BDC ( )Tj EMC (\031 \024\007\027\024\020\024 \023\026\006\017\036\027\021\026 \(1/150\)\ )Tj /Span<>> BDC ( )Tj EMC (\227 \035\026\036\030)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc T* (\027\026\016 \021\036\030\n\024\024\002\035\017\021\036\030\026\006\017\016\ \f\r\017\013\036\r\024\020\024 \b\024\007\026.)Tj 0 Tc 0.093 Tw T* (\204\036\007\017\026\027\026 \023\036\030\017\024\007\026 \027\026\002\035\ \033\007\036\027\017\016 \026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \f\024\f\021\026)Tj 0 Tw (-)Tj 0.042 Tw T* [(\r\017\035\026 )0.5(4,2 \(3,1;6\) \(3\2266\) )0.5(\n\036\f\016\006\026. )0.5(\025\024\035\017\004\036\f\021\r\024 )0.5(\023\026\006\017\036\027\021\024\r )]TJ 0.01 Tw T* (\f\024 \f\021\024\n\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \f\024\f\021\026\r\035\016\035\024 18/1\ 50 \(12%\), \023\024)Tj 0 Tw (-)Tj 0.033 Tw T* (\f\035\036 \024\023\036\030\026\006\017\017 \036\013\201 20 \023\026\006\ \017\036\027\021\026\n \002\t\035\026 \f\235\024\030\n\017\030\024\r\026\ \027\026 )Tj 0.247 Tw T* (\f\021\024\n\026. \215\024\f\035\036 \026\032\017\r\035\036\027\017\016\ \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \030\026\ \027, )Tj 0.29 Tw T* (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024-\r\024\f\f\021\026\ \027\024\r\017\021\036\035\034\027\031\033 \024\023\036\030\026\006\017\033\ \r\t)Tj 0 Tw (-)Tj 0.107 Tw T* (\023\024\035\027\017\035\017 \031)Tj /Span<>> BDC ( )Tj EMC (7/38 \(18%\) \023\026\006\017\036\027\021\024\r. \215\024\f\035\036 \b\017\ \030\031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.052 Tw T* (\f\022\024\020\024 \035\036\004\036\027\017\016 \023\026\006\017\036\027\ \021\026\n \023\024\r\021\024\030\027\024 \002\t\035\017 \r\t\023\024\035\ \027\036\027\t )Tj 0.117 Tw T* [(\221\217\211\003\230 )0.5(\023\030\016\n\024\005 \022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\235\017\027\022\021\036\030\024\n\036\021\030\017\016 \f)Tj /Span<>> BDC ( )Tj EMC 18.645 0 Td (\024\006\036\027\022\024\005 )Tj 0.119 Tw -18.645 -1.218 Td [(\f\017\n\023\021\024\n\024\r \026\027\026\035\034\027\024\005 \017\027\022\ \024\027\021\017\027\036\027\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.123 Tw T* [(\f\024 \001\022\026\035\024\005 W)22(e)-18(xner. \211\022\026\026\027\027\t\036 \017\f\f\035\036\007\024\r\026\027\ \017\016 \r\t\023\024\035)]TJ 0 Tw (-)Tj 0.027 Tw T* (\027\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (6 \n\036\f\016\006\036\r \023\024\f\035\036 \024\023\036\030\026\021\017\ \r\027\024\020\024 )Tj 0 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026.)Tj /T1_2 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf -0.084 Tw 0 -1.218 TD [(\212\026\027\027\t\036 \007\035\016 \026\027\026\035\017\026 \002\t\035\ \017 \r\027\036\f\036\027\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\220\035\036\022\021\030\024\027\027\031\033 \021\026\002)Tj /Span<>> BDC (-)Tj EMC 0.177 Tw T* [(\035\017\006\031 E)35(x)-13(cel \(Micr)-32(osof)-28(t O)-32(f\225ce 2019\). \025\024\035\017\004\036\f\021\r\036\027\027\t\036 )]TJ -0.047 Tw 23.244 54.801 Td [(\007\026\027\027\t\036 )0.5(\023\030\036\007\f\021\026\r\035\036\027\t \n\036\007\017\026\027\024\005\ \(Me\), \027\017\032\027\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.871 0 Td (\r\036\030\b)Tj 0 Tw (-)Tj -0.07 Tw -19.871 -1.218 Td (\027\017\n \022\r\026\030\021\017\035\016\n\017 \(Q1; Q3\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\017\027\017\n\026\035\034\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022)Tj 0 Tw (-)Tj 0.484 Tw T* [(\f\017\n\026\035\034\027\t\n )0.5(\027\026\004\036\027\017\016\n\017 )0.5(\(min-max\). )0.6(\222\021\026\021\017\f\021\017\004\036\f\022\017 )]TJ 0.19 Tw 0 -1.218 TD (\027\026\004\017\n\t\n\017 \f\004\017\021\026\035\017 \030\026\035\017\ \004\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 )Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.19 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. )Tj 0.213 Tw 0 -1.218 TD (\212\035\016 \f\030\026\r\027\036\027\017\016 \004\026\f\021\024\021\t \027\ \036\007\024\f\021\026\021\024\004\027\024\f\021\017 \026\027\026\035\034\ \027\024\020\024 )Tj 0.212 Tw 0 -1.218 TD (\f\235\017\027\022\021\036\030\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\021\007\026\035\201\027\027\024\n \023\024\f\035\036\024\023\036\ )Tj 0 Tw (-)Tj 0.318 Tw 0 -1.218 TD [(\030\026\006\017\024\027\027\024\n \023\036\030\017\024\007\036 \017\f\023\ \024\035\034\024\r\026\027 )0.5(\021\036\f\021 \204\026\022\203\036\n\026\030\026. )]TJ 0.449 Tw 0 -1.218 TD (\222\030\026\r\027\036\027\017\036 \022\024\035\017\004\036\f\021\r\036\027\ \027\t\b \023\036\030\036\n\036\027\027\t\b \r\t\023\024\035\027\036)Tj 0 Tw (-)Tj 0.549 Tw 0 -1.218 TD (\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \027\036\023\026\030\026\n\036\021\030\017\004\036\ \f\022\024\020\024 T-\022\030\017\021\036\030\017\016 )Tj 0.128 Tw 0 -1.218 TD (\200\017\035\022\024\022\f\024\027\026 \007\035\016 \f\r\016\026\027\027\ \t\b \r\t\002\024\030\024\022. \202\027\026\035\017 \022\035\017\027\017\ )Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD [(\022\024-\026\027\026\n\027\036\f\021\017\004\036\f\022\017\b )0.6(\235\026\022\021\024\030\024\r )0.6(\030\017\f\022\026 )0.5(\r\t\023\024\035\027\036\027 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.757 0 Td (\023\024)Tj 0 Tw (-)Tj 0.028 Tw -20.757 -1.218 Td (\n\024\013\034\033 \002\017\027\026\030\027\024\005 \035\024\020\017\f\021\ \017\004\036\f\022\024\005 \030\036\020\030\036\f\f\017\017, \023\024\035\ \031\004\036\027)Tj 0 Tw (-)Tj 0.263 Tw 0 -1.218 TD (\027\t\036 \030\036\031\035\034\021\026\021\t \023\030\036\007\f\021\026\ \r\035\036\027\t \024\021\027\024\001\036\027\017\036\n \001\026\027\f\024\ \r )Tj 0.112 Tw 0 -1.218 TD (\(\210\231\) \017)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034\027\t\n \017\027\021\036\030\r\ \026\035\024\n, \030\026\f\f\004\017\021\026\027)Tj 0 Tw (-)Tj 0.077 Tw 0 -1.218 TD (\027\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\024\007\031 )0.5(\200\026\035\034\007\026. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024\n )]TJ 0.046 Tw 0 -1.218 TD (\031\030\024\r\027\036 \030\026\035\017\004\017\005 \()Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.046 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\) \007\026\027\027\t\036 \023\026\030\026\n\036\021\030\t \r\022\035\ \033)Tj 0 Tw (-)Tj 0.276 Tw T* (\004\026\035\017\f\034 \007\035\016 \023\030\024\r\036\007\036\027\017\016\ \n\027\024\020\024\235\026\022\021\024\030\027\024\020\024 \026\027\026\ \035\017\026. )Tj 0.069 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \007\026\027\027\t\b \r\t\023\024\035\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\026\n)Tj 0 Tw (-)Tj T* [(\n\036 S)15(t)15(a)15(t)-32(ist)-31.9(ica 13.3 \(TIBC)13(O S)-15.9(ofr)-38(w)-12(ar)-24(e Inc., \222\231\202\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 371.6679 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.565 Tw 10 0 0 10 274.9606 347.3119 Tm (\232\026\f\021\024\021\026 \022\035\017\027\017\004\036\f\022\024\005 \027\ \036\007\024\f\021\026\021\024\004\027\024\f\021\017 \026\027\026\035\034\ \027\024\020\024 )Tj 0.054 Tw T* (\f\235\017\027\022\021\036\030\026 \(\203\202\222\) \002\t\035\026 \024\006\ \036\027\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \002\036 \f\021\024)Tj 0 Tw (-)Tj -0.001 Tw T* (\n\t \(117/150\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 81/117)Tj /Span<>> BDC ( )Tj EMC (\(69%\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026)Tj 0 Tw (-)Tj -0.001 Tw T* (\006\017\017, 83/117)Tj /Span<>> BDC ( )Tj EMC (\(71%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\f\035\036 \024\023\036\030\026\006\017\017. \222\021\026\021\ \017\f\021\017\004\036\f\022\017 )Tj 0.019 Tw T* (\027\026\004\017\n\t\b \030\026\035\017\004\017\005 \022\026\022 \007\024\ , \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\t)Tj 0 Tw (-)Tj T* (\016\r\035\036\027\024 \027\036 \002\t\035\024 \()Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,84\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.095 Tw T* (\204\036\007\017\026\027\026 \022\024\035\017\004\036\f\021\r\026 \002\026\ \035\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner \f\024\f\021\026)]TJ 0 Tw (-)Tj T* (\r\017\035\026 3 \(1;7\) \(0\22618\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017, 5)Tj /Span<>> BDC ( )Tj EMC (\(1;9\) \(0\22618\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.464 Tw T* (\023\024\f\035\036 \024\023\036\030\026\006\017\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \007\026\027\027\t\b \r\t\016\r\035\036\027\024\ )Tj -0.004 Tw T* (\031\r\036\035\017\004\036\027\017\036 \022\024\035\017\004\036\f\021\r\026\ \002\026\035\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 W)22(e)-18(xner \r)]TJ /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.234 Tw T* [(\007\026\035\201\027\027\024\n )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.6(\023\036\030\017\024\007\036 )0.5(\()]TJ /T1_3 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.234 Tw /Span<>> BDC ( )Tj EMC 18.589 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.966 0 Td (0,007\) )Tj 0 Tw -19.555 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.244 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\ \017 \235\026\022\021\024\030\026\n\017 \030\017\f\022\026 \030\026\r\017\ )Tj 0 Tw (-)Tj 0.161 Tw T* (\021\017\016 \203\202\222, \023\024 \022\035\017\027\017\004\036\f\022\017\ \n \007\026\027\027\t\n, \f\024\020\035\026\f\027\024 \030\036\031\035\034\ )Tj 0 Tw (-)Tj 0.166 Tw T* (\021\026\021\026\n \031\027\017\r\026\030\017\026\027\021\027\024\020\024\ \026\027\026\035\017\026, \f\021\026\035\017: \007\035\017\021\036\035\ \034\027\024\f\021\034 )Tj 0.129 Tw T* [(\026\027\026\n\027\036\026 \023\036\030\017\026\027\026\035\034\027\t\b\ )0.5(\023\030\024\016\r\035\036\027\017\005 \002\024\035\036\027\017 \025\030\ \024\027\026 )]TJ 0.119 Tw T* (\(\210\231)Tj /Span<>> BDC ( )Tj EMC 2.093 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.851 0 Td [(1,17; )0.5(95% )0.6(\212\230: )0.5(1,01\2261,38; )]TJ /T1_3 1 Tf 0 Tw 10.916 0 Td (\032)Tj /T1_1 1 Tf 0.119 Tw /Span<>> BDC ( )Tj EMC 0.829 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.851 0 Td [(0,04\), )0.5(\024\023\036\030\026\006\017\017 )]TJ 0.213 Tw -15.542 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.446 0 Td [(\023\024\r\024\007\031 )0.5(\215\215\207\025 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.041 0 Td [(\026\027\026\n\027\036\036 )0.6(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 6.513 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.945 0 Td [(0,33; )0.5(95% )0.5(\212\230: )]TJ 0 Tw -15.946 -1.218 Td (0,15\2260,75; )Tj /T1_3 1 Tf 4.457 0 Td (\032)Tj /T1_1 1 Tf -0.013 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\), \022\024\035\017\004\036\f\021\r\024 \r\f\022\030\t\021\017\005\ \023\026\030\026\023\030\024\022)Tj 0 Tw (-)Tj 0.039 Tw -4.457 -1.218 Td (\021\017\021\026 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,85; 95% \212\230: 1,12\2263,08, )Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.039 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,017\), \022\024\035\017)Tj 0 Tw (-)Tj -0.049 Tw T* (\004\036\f\021\r\024 \024\023\036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\215\207\025 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,16; 95% \212\230: )Tj 0 Tw T* (1,01\2264,6; )Tj /T1_3 1 Tf 3.994 0 Td (\032)Tj /T1_1 1 Tf 0.024 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,046\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\024 \f\r\017\013\036\005 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,25; )Tj 0 Tw -3.994 -1.218 Td (95% \212\230: 1,04\2264,87; )Tj /T1_3 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,039\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 274.9606 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \232\020\024\023\031\023\020 \n\f\022\025\022\007\027\024\n\031\235 \001\ \003\205)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( T)-6.4(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(r)-2(e)-9.4(q)-3(u)-3.2(e)-7(n)-2.9(c)-32.4(y o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(c)-1.1(li)3.9(n)1.7(i)-1.8(c)3.2(a)-4.5(l A)-17.9(I)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 274.9606 715.181 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 694.1118 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 360.25 715.181 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 391.4311 715.181 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 391.4311 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 422.6122 715.181 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 453.7933 715.181 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.1118 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 275.2106 682.8925 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 391.1811 694.1118 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 391.4311 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 694.1118 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 422.6122 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 453.7933 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 682.8925 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 274.9606 682.6425 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 275.2106 671.1813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 360.25 682.6425 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 360.25 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 682.6425 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 391.4311 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 682.6425 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 422.6122 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 682.6425 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.1813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 275.2106 659.97 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 360 671.1813 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 360.25 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 671.1813 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 391.4311 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 671.1813 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 422.6122 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.97 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 274.9606 659.72 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 360.25 659.72 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 391.4311 659.72 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 422.6122 659.72 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 453.7933 659.72 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 302.8293 696.0118 Tm (\021\f\t\b\t\201\r\217\220\004\235 \025\032\255)Tj 11.437 1.317 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t)Tj 1.425 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (117\))Tj /T1_2 1 Tf 8.406 -0.116 Td (p)Tj /T1_5 1 Tf -8.781 -1.317 Td (\031\004)Tj 3.664 0 Td (\025\r\003)Tj /T1_1 1 Tf -19.249 -1.433 Td (\212\024 \024\023\036\030\026\006\017\017)Tj T* (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (117\))Tj 11.695 1.2 Td (\212\026)Tj 3.927 0 Td (69)Tj 3.898 0 Td (12)Tj 4.264 0 Td (0,84)Tj -12.288 -1.433 Td (\203\036\021)Tj 4.127 0 Td (14)Tj 3.898 0 Td (22)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 511.9769 56.0378 Tm (31)Tj ET endstream endobj 1425 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1426 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1427 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1428 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1429 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1588 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.002 Tc 0.423 Tw 10 0 0 10 70.8661 724.8299 Tm [(\235\031\027\022\006\017\017 \026\023\017\030\026\021\036\035\034\027\024\ \020\024 \026\023\023\026\030\026\021\026 \023\030\016\n\024\005 \022\017\ \001\022\017)-2( )]TJ 0.139 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \017\f\f\035\036\007\031\036\n\t\b \023\024\ \022\026\026\021\036\035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\024\027\026\035\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.099 Tw T* [(\017\030\024\r\026\021\034 \021\026\022\021\017\022\031 \b\017\030\031\030\ \020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016. \211\004\ \017\021\t\r\026\016)-2( )]TJ 0.351 Tw T* (\027\036\024\007\027\024\022\030\026\021\027\t\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\026\007\027\036\n \023\030\024\b\024\007\036)-2( )]TJ 0.095 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \215\215\207\025, \007\026\027\027\026\016 \022\024\ \020\024\030\021\026 \023\026\006\017\036\027\021\024\r \017\f\b\024\007\ \027\024)-2( )]TJ -0.042 Tw T* (\017\n\036\036\021 \r\t\f\024\022\017\005 \030\017\f\022 \030\026\r\017\ \021\017\016 \027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 \026\ \027\026\035\034)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.053 Tw 0 -1.218 TD [(\027\024\020\024 \f\235\017\027\022\021\036\030\026 \(\203\202\222\) [4\226\ 6]. \221\026\022, \007\035\017\021\036\035\034\027\t\005 \026\027\026\n\027\ \036)-2( )]TJ 0.029 Tw 0 -1.218 TD (\023\036\030\017\026\027\026\035\034\027\t\b \023\024\030\026\032\036\027\ \017\005, \027\026\035\017\004\017\036 2-\b \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \020\027\024\005)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.113 Tw T* [(\027\t\b )0.5(\026\021\201\022\024\r, \026)]TJ /Span<>> BDC ( )Tj EMC 6.398 0 Td [(\021\026\022\032\036 )0.5(\023\036\030\036\027\036\f\036\027\027\t\036 \030\026\027\036\036 \024\023\ \036\030\026\006\017\017)-2( )]TJ 0.111 Tw -6.398 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 )0.5(\f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017 \031\r\036\ \035\017\004\017\r\026\033\021 \001\026\027\f)-2( )]TJ 0 Tw T* [(\030\026\r\017\021\017\016 \026\027\026\035\034\027\024\005 \017\027\022\ \024\027\021\017\027\036\027\006\017\017 [7].)-2( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 566.5158 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.178 Tw 10 0 0 10 70.8661 542.1598 Tm (\230\031\004\017\021\034 \017\n\036\027\036\027\017\016 \023\024\022\026\ \026\021\036\035\036\005 \026\027\024\030\036\022\021\026\035\034\027\024\ \005 \n\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\024\n\036\021\030\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \024\006\036\027\022\017 \235\ \031\027\022\006\017\017 \007\036\030\032\026\027\017\016 )Tj 0.02 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\034\033 \025\030\024\027\026 \023\024\f\035\036 \023\ \030\024\r\036\007\036\027\017\016 \b\017)Tj 0 Tw (-)Tj 0.082 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \f\r\017\013\036\005 \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 456.9138 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.176 Tw 10 0 0 10 70.8661 432.5578 Tm (\222 \026\023\030\036\035\016 2018 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\036\027\021\016\002\030\034 2024 \020\020. \023\030\024\r\036\007\036\ \027\024 \030\036)Tj 0 Tw (-)Tj 0.402 Tw T* [(\021\030\024\f\023\036\022\021\017\r\027\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036, )0.5(\024\006\036\027\017\r\026\033\013\036\036 )0.6(\235\031\027\022)]TJ 0 Tw (-)Tj 0.641 Tw T* (\006\017\024\027\026\035\034\027\t\036 \030\036\031\035\034\021\026\021\ \t \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\ \027\017\016 )Tj 0.128 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\215\215\207\025. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017 \r\022\035\033\ \004\036\027\t )Tj 0.095 Tw T* (150)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\022\017\001\036\004\027\t\n\017 \f\r\017\013\026\n\017\ \030\026\035\017\004)Tj 0 Tw (-)Tj -0.06 Tw T* (\027\024\005 \f\021\036\023\036\027\017 \f\035\024\032\027\024\f\021\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\201\027\027\t\n \007\017\026\020\027\024\ \024\n )Tj -0.017 Tw T* (\253\002\024\035\036\027\034 \025\030\024\027\026\273. \215\030\036\024\ \002\035\026\007\026\035\017 \023\026\006\017\036\027\021\t \f\024 \f\035\ \024\032\027\t)Tj 0 Tw (-)Tj 0.101 Tw T* [(\n\017 \f\r\017\013\026\n\017 \f\024\020\035\026\f\027\024 \022\035\026\f\ \f\017\235\017\022\026\006\017\017 P)40(ar)-24(k)-10(s [8]. \221\026\022, )]TJ 0.159 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\004\036\027\t \ 88/150 \(59%\) \023\026\006\017\036\027\021\024\r )Tj 0.17 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.84 0 Td [(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\n\017 )0.6(\(\004\036\030\036 )0.5(\023\024\r\036\030\b\027\024\f\021\027\031\033 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 19.629 0 Td (\020\035\031)Tj 0 Tw (-)Tj 0.019 Tw -20.468 -1.218 Td (\002\024\022\031\033 \023\024\030\006\017\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\f\235\017\027\022)Tj /Span<>> BDC ( )Tj EMC 12.557 0 Td (\021\036\030\027\t\n\017 \f\r\017\013\026\n\017 \023\030\016)Tj 0 Tw (-)Tj 0.03 Tw -12.557 -1.218 Td (\n\024\005 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (127/150 \(85%\) \f\035\031\004\026\036\r \002\t\035\017 \r\t\016\r\035\036\ \027\t )Tj 0.048 Tw T* (\026\021\036\022\017. \222\021\024\017\021 \024\021\n\036\021\017\021\034\ \f\031\013\036\f\021\r\036\027\027\031\033 \030\026\027\024\030\024\007\ \027\024\f\021\034 )Tj 0.082 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \b\026\030\026\022\021\036\030\ \017\f\021\017\022\036 \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036)Tj 0 Tw (-)Tj -0.001 Tw T* (\007\024\r\026\027\017\036 \023\026\006\017\036\027\021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\f\021\017 \026\027\026\n\027\036\026\ \002\024\035\036)Tj 0 Tw (-)Tj 0.163 Tw T* (\027\017 \025\030\024\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \235\024\030\n\036, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024\035\031\004\026\036\n\024\005 \022\024\027\ \f\036\030)Tj 0 Tw (-)Tj 0.116 Tw T* (\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\017. \221\024\035\034\ \022\024 \031)Tj /Span<>> BDC ( )Tj EMC (41/150 \(27%\) \023\026\006\017\036\027\021\026 )Tj 0.032 Tw T* (\002\t\035\026 \030\036\n\017\f\f\017\016 \026\002\024\035\036\r\026\027\ \017\016. \212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\ \036\026 )Tj 0.118 Tw T* (\215\215\207\025 \f\024\f\021\026\r\017\035\026 \024\021 2-\b \n\036\f\016\ \006\036\r \007\024)Tj /Span<>> BDC ( )Tj EMC (19 \035\036\021, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.103 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC 0.78 0 Td [(\002\024\035\034\001\036\005 )0.6(\004\026\f\021\017 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\(57,3%\) )0.6(\030\026\027\036\036 )0.5(\002\t\035\017 )0.5(\r\t)]TJ 0 Tw (-)Tj -0.007 Tw -0.78 -1.218 Td (\023\024\035\027\036\027\t \030\026\035\017\004\027\t\036 \r\017\007\t \ \024\023\036\030\026\021\017\r\027\t\b \r\n\036\001\026\021\036\035\034\f\ \021\r )Tj 0.392 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\036\030\017\026\027\026\035\034\027\t\b \023\ \030\024\016\r\035\036\027\017\005. \215\024\007\030\024\002\027\026\016\ )Tj -0.012 Tw T* (\022\035\017\027\017\022\024-\026\027\026\n\027\036\f\021\017\004\036\f\022\ \026\016 \b\026\030\026\022\021\036\030\017\f\021\017\022\026 \023\026\006\ \017\036\027\021\024\r )Tj 0 Tw T* (\024\021\024\002\030\026\032\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 1.)Tj -0.012 Tc 0.178 Tw T* (\215\026\006\017\036\027\021\t \002\t\035\017 \024\002\f\035\036\007\024\ \r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC [(\031\f\035\024\r\017\016\b \f\021\026\006\017\024\027\026\030\026)-12( )]TJ 0.118 Tw T* (\024\021\007\036\035\036\027\017\016 \020\026\f\021\030\024\220\027\021\036\ \030\024\035\024\020\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \022\024\035\024\027\024- \017)Tj /Span<>> BDC ( )Tj EMC (\020\026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.691 Tw T* [(\f\021\030\024\f\022\024\023\017\017, \031\035\034\021\030\026\r\031\022\ \024\r\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \(\211\003\ \230\))-12( )]TJ 0.513 Tw T* (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, \022\024\n\023\034\ \033\021\036\030\027\024\005 \(\025\221\) \220\027\021\036\030\024\020\030\ \026)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.286 Tw T* (\235\017\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \021\030\026\027\f\030\036\022\021\026\035\034\027\ \024\020\024 \031\035\034\021\030\026\r\031\022\024\r\024)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.202 Tw T* [(\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.5(\(\221\217\211\003\230\) )0.5(\024\023\030\036\007\036\035\016\035\017)-12( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc -0.023 Tw 9 0 0 9 303.3071 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \202\f\022\025\022\n\031-\020\025\020\026\025\027\024\023\022\007\027\024\ \n\020\t \200\020\032\020\n\023\027\032\022\024\023\022\n\020 \033\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\006\022\027\025\023\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( C)1.2(li)3.9(n)1.7(i)-1.8(c)3.3(a)-4.5(l a)-5.1(n)-4.8(d a)-5.1(na)-5(mn)-2.4(e)-22(s)-14.8(t)-29.1(i)-1.8(c c)-2.4(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.7(c o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.3(e)-7(n)-0.6(t)-32.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 704.381 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 684.1153 cm 0 0 m 0 20.016 l S Q q 1 0 0 1 467.9665 704.381 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 684.1153 cm 0 0 m 0 20.016 l S Q q 1 0 0 1 524.6594 684.1153 cm 0 0 m 0 20.016 l S Q q 1 0 0 1 303.3071 683.8653 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 673.1075 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 467.9665 683.8653 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 673.1075 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 524.6594 673.1075 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 303.3071 672.8575 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 662.0999 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 467.9665 672.8575 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 662.0999 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 524.6594 662.0999 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 303.3071 661.8499 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 632.0921 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 467.9665 661.8499 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 632.0921 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 524.6594 632.0921 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 303.3071 631.8421 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 602.0844 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 467.9665 631.8421 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 602.0844 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 524.6594 602.0844 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 303.3071 601.8344 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 572.0766 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 467.9665 601.8344 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 572.0766 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 524.6594 572.0766 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 303.3071 571.8266 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 523.0688 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 467.9665 571.8266 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 523.0688 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 524.6594 523.0688 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 303.3071 522.8188 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 502.5611 cm 0 0 m 0 20.008 l S Q q 1 0 0 1 467.9665 522.8188 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 502.5611 cm 0 0 m 0 20.008 l S Q q 1 0 0 1 524.6594 502.5611 cm 0 0 m 0 20.008 l S Q q 1 0 0 1 303.3071 502.3111 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 482.0534 cm 0 0 m 0 20.008 l S Q q 1 0 0 1 467.9665 502.3111 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 482.0534 cm 0 0 m 0 20.008 l S Q q 1 0 0 1 524.6594 482.0534 cm 0 0 m 0 20.008 l S Q q 1 0 0 1 303.3071 481.8034 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 442.5457 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 467.9665 481.8034 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 442.5457 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 524.6594 442.5457 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 303.3071 442.2957 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 365.0379 cm 0 0 m 0 77.008 l S Q q 1 0 0 1 467.9665 442.2957 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 365.0379 cm 0 0 m 0 77.008 l S Q q 1 0 0 1 524.6594 365.0379 cm 0 0 m 0 77.008 l S Q q 1 0 0 1 303.3071 364.7879 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 316.0302 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 467.9665 364.7879 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 316.0302 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 524.6594 316.0302 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 303.3071 315.7802 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 276.5224 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 467.9665 315.7802 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 276.5224 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 524.6594 276.5224 cm 0 0 m 0 39.008 l S Q q 1 0 0 1 303.3071 276.2724 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 246.5147 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 467.9665 276.2724 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 246.5147 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 524.6594 246.5147 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 303.3071 246.2647 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 197.507 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 467.9665 246.2647 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 197.507 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 524.6594 197.507 cm 0 0 m 0 48.508 l S Q q 1 0 0 1 303.3071 197.257 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 119.9992 cm 0 0 m 0 77.008 l S Q q 1 0 0 1 467.9665 197.257 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 119.9992 cm 0 0 m 0 77.008 l S Q q 1 0 0 1 524.6594 119.9992 cm 0 0 m 0 77.008 l S Q q 1 0 0 1 303.3071 119.7492 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 89.9915 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 467.9665 119.7492 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 89.9915 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 524.6594 89.9915 cm 0 0 m 0 29.508 l S Q q 1 0 0 1 303.3071 89.7415 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 303.5571 78.9837 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 467.9665 89.7415 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 78.9837 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 524.6594 78.9837 cm 0 0 m 0 10.508 l S Q q 1 0 0 1 303.3071 78.7337 cm 0 0 m 164.659 0 l S Q q 1 0 0 1 467.9665 78.7337 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 366.1221 691.2232 Tm (\200\004\006\004\214\r\003\006\013)Tj 13.942 0.594 Td (\200\004\204\t\r\b\003\013, )Tj 0.665 -1.187 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (150)Tj /T1_0 1 Tf -22.074 -1.376 Td (\204\036\007\017\026\027\026 \r\024\030\026\f\021\026 \(\022\r\026\030\021\ \017\035\017\))Tj 21.598 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(24;41\))Tj -21.598 -1.376 Td (\204\036\007\017\026\027\026 \230\204\221, \022\020/\n)Tj 4.664 0 0 4.664 369.0629 667.1217 Tm (2)Tj 8 0 0 8 371.3949 664.4577 Tm ( \(\022\r\026\030\021\017\035\017\))Tj 12.538 0 Td (22,45)Tj /Span<>> BDC ( )Tj EMC (\(20;25,3\))Tj -20.663 -1.376 Td (\215\024\035, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\240\036\027\f\022\017\005)Tj 0 -1.187 TD (\204\031\032\f\022\024\005)Tj 20.848 1.187 Td (77)Tj /Span<>> BDC ( )Tj EMC (\(51,3\))Tj T* (73)Tj /Span<>> BDC ( )Tj EMC (\(48,7\))Tj -21.911 -1.376 Td (\025\031\030\036\027\017\036, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\203\036\021)Tj 21.191 1.187 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(31\))Tj -0.25 -1.187 Td (104)Tj /Span<>> BDC ( )Tj EMC (\(69\))Tj -22.004 -1.376 Td (\222\024\023\031\021\f\021\r\031\033\013\017\036 \026\002\024\035\036\r\ \026\027\017\016, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\203\036\021)Tj 20.941 1.187 Td (102)Tj /Span<>> BDC ( )Tj EMC (\(68\))Tj 0.25 -1.187 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(32\))Tj -22.254 -1.376 Td (\203\026\035\017\004\017\036 \f\021\024\n\t, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\230\035\036\024\f\021\024\n\026)Tj T* (\025\024\035\024\f\021\024\n\026)Tj T* (\203\036\021)Tj 21.191 3.563 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(12\))Tj 0.265 -1.187 Td (11/18)Tj 0.25 -1.187 Td (7/18)Tj -0.765 -1.187 Td (132)Tj /Span<>> BDC ( )Tj EMC (\(88\))Tj -22.004 -1.376 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \023\036\030\017\026\027\026\035\034\027\t\b \f\r\017\013\036\005, )Tj T* (\035\036\021 \(\022\r\026\030\021\017\035\017\) \(\n\017\027.\226\n\026\022\ \f.\))Tj 20.926 1.187 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;5\) \(0,25\226)Tj 2.129 -1.187 Td (19\))Tj -23.055 -1.376 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \026\027\026\n\027\036\026\ \207\025, \035\036\021 \(\022\r\026\030\021\017\035\017\) )Tj T* (\(\n\017\027.-\n\026\022\f.\))Tj 20.926 1.187 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(2;8\) \(0,16\226)Tj 2.129 -1.187 Td (32\))Tj -23.055 -1.376 Td (\210\023\036\030\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\036\030\017\026\027\026\035\034\027\t\b \023\ \030\024\016\r\035\036\027\017\005 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\203\036\021)Tj 20.848 1.187 Td (86)Tj /Span<>> BDC ( )Tj EMC (\(57,3\))Tj T* (64)Tj /Span<>> BDC ( )Tj EMC (\(42,7\))Tj -21.911 -1.376 Td (\221\017\023 \024\023\036\030\026\006\017\005, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\200\f\022\030\t\021\017\036 \023\026\030\026\023\030\024\022\021\017\021\ \026)Tj T* (\230\f\f\036\004\036\027\017\036 \f\r\017\013\026)Tj T* (\215\030\024\r\036\007\036\027\017\036 \035\017\020\026\021\031\030\t)Tj T* (\217\026\007\036\035\034\027\024\036 \031\001\017\r\026\027\017\036 \030\ \036\022\021\024\r\026\020\017\027\026\035\034\027\024\020\024 )Tj T* (\f\r\017\013\026)Tj T* (\214\026\036\030\027\026\016 \021\036\030\n\024\024\002\035\017\021\036\ \030\026\006\017\016 \f\r\017\013\036\r\024\020\024 \b\024\007\026)Tj T* (\203\036\021)Tj 21.191 7.125 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(31\))Tj T* (20)Tj /Span<>> BDC ( )Tj EMC (\(13\))Tj T* (25)Tj /Span<>> BDC ( )Tj EMC (\(17\))Tj 0.5 -2.375 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(1\))Tj -0.5 -1.187 Td (56)Tj /Span<>> BDC ( )Tj EMC (\(37\))Tj -22.254 -1.376 Td (\205\024\030\n\026 \002\024\035\036\027\017 \025\030\024\027\026 \(\023\ \024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n )Tj T* (\022\024\035\024\027\024\f\022\024\023\017\017\), )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\230\035\036\017\021)Tj T* (\230\035\036\024\022\024\035\017\021)Tj T* (\025\024\035\017\021)Tj 21.191 3.563 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(15\))Tj T* (66)Tj /Span<>> BDC ( )Tj EMC (\(44\))Tj T* (62)Tj /Span<>> BDC ( )Tj EMC (\(41\))Tj -22.254 -2.563 Td (\202\022\021\017\r\027\024\f\021\034 \002\024\035\036\027\017 \025\030\024\ \027\026 \(\023\024 \007\026\027\027\t\n )Tj T* (\022\024\035\024\027\024\f\022\024\023\017\017\), )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\203\036\021)Tj 20.941 1.187 Td (109)Tj /Span<>> BDC ( )Tj EMC (\(73\))Tj 0.25 -1.187 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(27\))Tj -22.254 -1.376 Td (\215\030\024\022\021\017\021 \(\023\024 \007\026\027\027\t\n \022\024\035\ \024\027\024\f\022\024\023\017\017\), )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\203\036\021)Tj 21.191 1.187 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(37\))Tj T* (95)Tj /Span<>> BDC ( )Tj EMC (\(63\))Tj -22.254 -1.376 Td (\217\026\f\023\024\035\024\032\036\027\017\036 \f\r\017\013\026, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\215\036\030\036\007\027\017\005)Tj T* (\003\026\007\027\017\005)Tj T* (\207\024\022\024\r\024\005)Tj T* (\207\024\035\036\036 1 \f\r\017\013\026)Tj 21.191 3.563 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(27\))Tj T* (70)Tj /Span<>> BDC ( )Tj EMC (\(47\))Tj 0.5 -1.187 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(6\))Tj -0.5 -1.187 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(20\))Tj -22.254 -1.376 Td (\216\024\007 \f\r\017\013\026, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\230\027\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\023\024\007\022\024\032\027\026\016 \023\024\030\006\017\016)Tj T* (\023\024\r\036\030\b\027\024\f\021\027\026\016 \023\024\030\006\017\016)Tj T* (\020\035\031\002\024\022\026\016 \023\024\030\006\017\016)Tj T* (\233\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj T* (\217\036\022\021\024\r\026\020\017\027\026\035\034\027\t\005)Tj 21.191 7.125 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(15\))Tj T* (44)Tj /Span<>> BDC ( )Tj EMC (\(29\))Tj 0.265 -1.187 Td (21/44)Tj T* (18/44)Tj 0.25 -1.187 Td (5/44)Tj -0.515 -1.187 Td (65)Tj /Span<>> BDC ( )Tj EMC (\(43\))Tj T* (19)Tj /Span<>> BDC ( )Tj EMC (\(13\))Tj -22.254 -1.376 Td (\203\026\035\017\004\017\036 \026\021\201\022\024\r, )Tj /T1_3 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.187 Td (\212\026)Tj T* (\203\036\021)Tj 20.941 1.187 Td (127)Tj /Span<>> BDC ( )Tj EMC (\(85\))Tj 0.25 -1.187 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(15\))Tj -22.254 -1.376 Td (\025\024\035\017\004\036\f\021\r\024 \026\021\201\022\024\r \(\022\r\026\ \030\021\017\035\017\) \(\n\017\027.\226\n\026\022\f.\))Tj 21.084 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\) \(0\2264\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.09 56.0378 Tm (30)Tj ET endstream endobj 1587 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\210\002\t\r\n\025\t\017\020\200\t\217\004 \005\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 \020\004\225\004\t\n\213 )]TJ 0 -1 TD [(\224\005\213\024\025\r\n\204\004\225\t\217\220 \016\b\n\234\004\221 \002\ \022\224\017\n\004\t\026)11(\025\b \016\022\255\025\020\004\212\t\200\206 \037)19.9(\005\025\t\017)]TJ 42.41 1 Td [(Functional r)31(esults of\022sur)31.1(gical tr)31(eatment of\022anal )]TJ 2.765 -1 Td [(f)-21(istulas in patients with Cr)20(ohn\236)63(s disease)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 328.5705 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 328.5705 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 291.3627 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 291.3627 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 237.2935 cm 0 0 m 453.543 0 l S Q BT /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 105.47 723.8861 Tm [(Functional r)31(esults of\022)-23.3(sur)31(gical tr)31(eatment of\022)-23.3(anal )]TJ 1.394 -1.167 Td [(f)-21(istulas in patients with Cr)20(ohn\236)63(s disease)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 678.3822 Tm [(Iv)10(an\022)-23.3(S.\022)-23.2(Anosov)]TJ 8.162 0 0 8.162 126.5827 683.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 131.2187 678.3822 Tm [(, T)40(at)-20(y)21(ana\022)-23.2(A)-31(.\022)-23.3(Er)-31(y)10(sh)11(ov)10(a)]TJ 0 Tw 8.162 0 0 8.162 255.5633 683.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 260.1993 678.3822 Tm [(, Roman\022)-23.2(Y)39.9(u.\022)-23.2(Khr)-31(y)10(ukin)]TJ 0 Tw 8.162 0 0 8.162 381.2396 683.0442 Tm (1)Tj 14 0 0 14 385.8755 678.3822 Tm (, )Tj -24.525 -1.143 Td [(Ok)11(sana\022)-23.2(Y)40(u.\022)-23.3(F)15(omenk)11(o)]TJ 8.162 0 0 8.162 161.0927 667.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 165.7286 662.3822 Tm [(, V)31(aler)-30.9(y\022)-23.3(L.\022)-23.3(Denisenk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 284.7808 667.0442 Tm (2)Tj 0.023 Tw 14 0 0 14 289.4167 662.3822 Tm [(, Eduar)31(d\022)-23.3(V)62.1(.\022)-23.3(Denisenk)11(o)]TJ 0 Tw 8.162 0 0 8.162 413.6633 667.0442 Tm (2)Tj 14 0 0 14 418.2993 662.3822 Tm (, )Tj -26.841 -1.143 Td [(Dylan\022)-23.2(M.D.\022)-23.3(McCr)31(eer)-31(y)]TJ 8.162 0 0 8.162 166.8041 651.0442 Tm (1)Tj 5.83 0 0 5.83 42.5197 632.043 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 628.713 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 620.043 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 616.713 Tm [(Vitebsk Regional Clinical Specializ)10.1(ed Center \(Nekr)21(asov)10(a\022)-23.2(st., 1)75(0, Vitebsk, 2)138(1)75(000)87(1)69(, Republic of\022)-23.3(Belar)10.1(us\))]TJ /T1_1 1 Tf 9 0 0 9 90.7087 598.209 Tm [(AIM: to assess the functional outcomes following manag)12(ement of per)-36.9(ianal f)-43(istulizing Crohn)24(\222)37(s disease.)]TJ 0.013 Tw 0 -1.111 TD [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a retrospectiv)13(e study w)13(as done from Ap)46(r)-37(il 2018 to Sep)13(tember 2024, com)16(par)-37(ing continence )]TJ 0.127 Tw T* [(function before and af)-45.9(ter surg)12(er)-42.9(y \(median follow-up 4.2 months\) in 150 patients with per)-36.9(ianal Crohn)24(\222)37(s disease )]TJ 0.032 Tw T* [(\(pCD\). Sphincter function w)13(as assessed before and af)-46(ter surg)12(er)-43(y using the W)30(e)-15(xner scale and anorectal manometr)-43(y)32(. )]TJ 0.108 Tw T* [(U)22(ni- and multiv)16(ar)-36.9(iate binar)-42.9(y logistic reg)14(ression analyses w)12(ere per)-34(for)-13.9(med to identify r)-37(isk factors for clinical anal )]TJ 0.023 Tw 0 -1.111 TD (incontinence \(AI\).)Tj 0.072 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the incidence of clinical anal incontinence \(AI\), def)-42.9(ined as a W)30(e)-15(xner score of)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(2, w)13(as assessed in non-)]TJ -0.027 Tw T* [(stoma patients and w)13(as 90/132 \(68%\) p)46(reoperativ)13(ely and 84/119 \(71%\) postoperativ)13(ely)32(. N)17(o signif)-43(icant dif)-39.9(ferences )]TJ 0.029 Tw T* [(in )0.6(freq)14(uency )0.5(w)12(ere )0.6(obser)-41.9(v)12.9(ed )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 12.018 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.761 0 Td [(0.84\). )0.6(How)12(ev)13(er)61(, )0.5(a )0.6(signif)-43(icant )0.6(increase )0.6(in )0.5(W)30(e)-15(xner )0.5(scale )0.6(scores )0.5(w)13(as )0.5(no)13(ted )0.6(in )0.5(the )0.5(late )]TJ 0.112 Tw -12.78 -1.111 Td [(postoperativ)13.1(e per)-36.9(iod \(p)46(reoperativ)13.1(e median: 3 points [Q1; Q3: 1; 7]; postoperativ)13(e median: 5 points [Q1; Q3: 1; )]TJ 0.04 Tw T* (9]; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.007\). U)22(niv)16(ar)-36.9(iate analysis identif)-42.9(ied factors associated with an increased r)-37(isk of clinical AI af)-46(ter surg)12(er)-43(y)12(: )]TJ 0.065 Tw T* [(long)12(er duration of per)-37(ianal CD sym)16(p)13(toms \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.17; 95% CI: 1.01\2311.38; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.04\), a histor)-43(y of surg)12(er)-43(y for anal )]TJ T* [(f)-43(istulas \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.33; 95% CI: 0.15\2310.75; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.008\), a higher number of p)46(revious operations \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.16; 95% CI: )Tj -0.031 Tw T* (1.01\2314.6; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.046\), including a g)14(reater number of p)46(revious incision and drainag)12(e p)46(rocedures for per)-37(ianal abscesses )]TJ 0.016 Tw 0 -1.111 TD (\(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.85; 95% CI: 1.12\2313.08; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.017\), and a higher number of rectal f)-43(istulas \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.25; 95% CI: 1.04\2314.87; )Tj 0.203 Tw 0 -1.111 TD (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.039\). How)12(ev)13(er)61(, multiv)16(ar)-37(iate analysis failed to conf)-42.9(ir)-14(m the statistical signif)-43(icance of these factors. The )]TJ 0.023 Tw T* [(manometr)-36.9(ic incidence of AI w)13(as 120/150 \(80%\) p)45.9(reoperativ)13.1(ely and 137/150 \(91%\) postoperativ)13(ely \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.0004\). )Tj 0.057 Tw T* [(P)18(atients with nor)-14(mal p)46(reoperativ)13(e manometr)-42.9(y had a higher incidence of postoperativ)13(e AI \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.02\). The A)14(v)13(erag)12(e )]TJ 0.09 Tw T* [(Anal R)21(esting Pressure w)13(as below the reference rang)12(e in 116 \(77%\) cases p)46(reoperativ)13(ely and in 137 \(91%\) cases )]TJ 0.009 Tw T* [(postoperativ)13.1(ely)42(, indicating a signif)-43(icant decrease af)-46(ter surg)12(er)-43(y \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.001\). N)17(o factors p)46(redisposing to an increased )]TJ 0.023 Tw T* [(r)-37(isk of manometr)-36.9(ic AI w)12(ere identif)-43(ied.)]TJ -0.02 Tw T* [(C)21(ON)22(CLUSION: the results obtained show)12.1(ed an increase in the rate of postoperativ)13(e anal incontinence in patients with )]TJ -0.008 Tw T* [(per)-37(ianal )0.6(Crohn)24(\222)37(s )0.6(disease. )0.5(It )0.6(is )0.5(necessar)-43(y )0.5(to )0.6(apply )0.5(an )0.6(individual )0.6(app)46(roach )0.6(to )0.5(surg)11.9(er)-43(y)42(, )0.5(taking )0.6(into )0.5(account )0.5(the )0.5(patient\222)37(s )]TJ 0.023 Tw 0 -1.111 TD [(medical histor)-43(y and cur)-16(rent condition.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 352.9398 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( Crohn)24(\222)37(s disease, anal sphincter dysfunction, anal incontinence, anorectal mano\ metr)-42.9(y)42(, per)-36.9(ianal Crohn)24(\222)37(s disease, pCD)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.035 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.2(O)-4.5(R)8.7( C)-17.4(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.021 Tc -0.035 Tw 6.375 0 Td [( A)-12.6(n)-11.9(o)-15.8(s)-19.1(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-26.8(S)-9.6(.)-23.5(, E)-1.9(r)-60.6(y)-28.9(s)-8.8(h)-10.9(o)-10.2(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)-23.9(A)-23(.)-23.5(, K)-20.5(h)-6.5(r)-60.6(y)-21.5(u)-9.6(k)-41.1(i)-3.2(n R)-21.4(.)51.7(Y)12.6(u)-9(.)-23.5(, F)-21(o)-9.2(m)-16.6(e)-11.5(n)-8.7(k)-3.7(o O)11.5(.)51.6(Y)12.6(u)-9(.)-23.5(, D)-21.9(e)-11.5(n)-13.9(i)-7.4(s)-22.9(e)-11.5(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.L)-29.4(.)-23.5(, D)-21.9(e)-11.5(n)-14(i)-7.4(s)-22.9(e)-11.5(n)-8.7(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)40.6(V)39.7(.)-23.5(, M)-8.3(c)-24.8(C)-15.4(r)-19(e)-25.2(e)-12.1(r)-60.6(y D)16.4(.)-7.3(M)-7.1(.)1.5(D)16.4(. F)-10.2(u)-5(n)-10(c)-41.5(t)-46.2(i)-6.8(o)-9.1(n)-7.8(a)-11.4(l)21( )]TJ 0.023 Tc 0.197 Tw -6.38 -1.2 Td [(r)-19.1(e)-22.8(s)-8.8(u)-8.4(l)-15.4(t)-48.9(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(s)-8.8(u)-7.6(r)-16.7(g)-28.9(i)-5(c)-21.5(a)-11.4(l t)-30.8(r)-19.1(e)-13(a)-18.2(t)-26.1(m)-16.6(e)-11.5(n)-17.3(t o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-7.6(n)-7.8(a)-11.4(l f)-63(i)-7.4(s)-29.3(t)-22.2(u)-8.4(l)-37.8(a)-26.6(s i)-3.2(n p)-20(a)-18.2(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h C)-15.4(r)-15.8(o)-12.7(h)-4.9(n)-12.8(\241)20.6(s d)-15.8(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.9(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.1(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf 0.013 Tc 0.207 Tw 43.285 0 Td [( 2)-18.9(0)-13.8(2)-5.8(6)9.9(;2)-11.4(5)-9.1(\()27.7(1)34.3(\))4.5(:)-7.7(2)-15.2(8)-34.2(\226)21.7(3)5.4(7)70.1(.)-10.3( \()-10.8(i)-13.3(n)-10.2( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.2(\).)13.1( )]TJ -0.013 Tw -43.285 -1.2 Td [(h)-27.2(t)-59.4(t)-39.4(p)-28.7(s)-18(:)-8.1(/)74.8(/)26.4(d)-21.1(o)-22.5(i)-10.2(.)-7.3(o)-21.8(r)-26.7(g)-32.8(/)1.2(1)4(0)-3.5(.)-15.6(3)-2.1(3)-25.9(8)-8.7(7)-5.3(8)-10(/)-2.2(2)-18.8(0)-0.7(7)-11.9(3)-23.3(-)31.2(7)0.7(5)-9.6(5)-18.9(6)-36.7(-2)-18.9(0)-13.8(2)-5.8(6)-36.7(-2)-11.4(5)-33.5(-)45.1(1)16.9(-2)-15.2(8)-35.7(-)22.7(3)5.4(7)]TJ /T1_2 1 Tf 0.01 Tc 0.09 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.5(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.095 Tw 10.72 0 Td [( )0.5(\036\032\013\213\031\021\020 )0.5(.\003., )0.5(\214\216\221\210 )0.5(\253\001\215\002\037 )0.6(\n\031\f\031\033\032\031\n\023\031\f\031\b\022\022 )0.5(\022\026\027\025\022 )0.5(\003.\001.)]TJ /Span<>> BDC ( )Tj EMC 24.694 0 Td [(\206\013\255\022\200\273 )0.5(\215\022\025\016\030\032\020\021\020 )0.5(\206\031\024\024\022\022, )0.5(\r\f.)]TJ /Span<>> BDC ( )Tj EMC 13.191 0 Td [(\205\020\f\t\026\020 )0.6(\003\030\022\f\t, )0.5(\030.)]TJ /Span<>> BDC ( )Tj EMC 7.379 0 Td (2, )Tj 0.023 Tw -55.989 -1.2 Td (\215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: teryshov\ a.7@gmail.com)Tj /T1_2 1 Tf 0.01 Tc 0.098 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.103 Tw 14.21 0 Td [( Er)-43(yshov)16.1(a T)63(.A., Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.215 -1.2 Td [(123423, R)22(ussia; e-mail: ter)-43(yshov)16(a.7@gmail.com)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 21.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 21.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 176.8199 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf -0.002 Tc 0.379 Tw 10 0 0 10 42.5197 152.4639 Tm [(\216\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 \023\036\030\017\026\027\026\035\034\027\t\b \023\030\024\016\r\035\ \036\027\017\005)-2( )]TJ 0.148 Tw 0 -1.218 TD (\002\024\035\036\027\017 \025\030\024\027\026 \(\215\215\207\025\), \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017)-2( )]TJ 0.354 Tw T* (\f\035\024\032\027\t\b \023\030\016\n\024\022\017\001\036\004\027\t\b \f\ \r\017\013\036\005, \024\f\021\026\201\021\f\016 \027\036\024\021\255)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.281 Tw T* (\036\n\035\036\n\024\005 \004\026\f\021\034\033 \022\024\n\023\035\036\022\ \f\027\024\020\024 \023\024\007\b\024\007\026 \022)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\033)-2( )]TJ 0.16 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\024\035\031\004\036\027\017\016 \017\n\017 \026\ \007\036\022\r\026\021\027\024\005 \022\024\027)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.131 Tw T* [(\f\036\030\r\026\021\017\r\027\024\005 )0.5(\021\036\030\026\023\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.157 0 Td [(\f\021\026\002\017\035\017\026\006\017\017 )0.5(\024\f\027\024\r\027\024\020\024 )0.6(\026)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.136 Tw -10.157 -1.218 Td (\002\024\035\036\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\235\026\036 \030\036\n\017\f\f\017\017 [1\2263]. \203\026)Tj /Span<>> BDC ( )Tj EMC [(\f\036\020\024\007\027\016\001\027\017\005)-2( )]TJ -0.027 Tw 23.244 9.742 Td [(\007\036\027\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 2.784 0 Td [(\n\017\030\024\r\024\005 )0.5(\035\017\021\036\030\026\021\031\030\036 )0.5(\022\030\026\005\027\036 )0.5(\n\026\035\024 )0.5(\030\026\002\024\021, )0.6(\023\024\f\r\016)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.053 Tw -2.784 -1.218 Td [(\013\201\027\027\t\b \017\027\f\021\030\031\n\036\027\021\026\035\034\027\ \024\005 \024\006\036\027\022\036 \235\031\027\022\006\017\017 \007\036\030\ \032\026\027\017\016)-2( )]TJ -0.008 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \ \035\036\004\036\027\017\016 \f\r\017\013\036\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.306 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\f\023\026\035\017\021\036\035\034\027\t\n\017 \026\002\024\035\036\ \r\026\027\017\016\n\017 \022\017\001\036\004\027\017\022\026)-2( )]TJ 0.293 Tw T* [(\(\200\003\025\). )0.5(\207\024\035\034\001\017\027\f\021\r\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\024\020\030\026\027\017\004\017\r\026\033\021\f\016)-2( )]TJ 0.081 Tw T* (\f\031\002\255\036\022\021\017\r\027\024\005 \024\006\036\027\022\024\005\ \f\017\n\023\021\024\n\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\026\n W)22(e)-17.9(xner)-2( )]TJ -0.029 Tw T* [(\017/\017\035\017 V)25(aize)-11(y, \r)]TJ /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \024\002\255\036\022\021\017\r\027\ \026\016 \024\006\036\027\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.128 Tw T* (\n\024\013\034\033 \n\036\021\024\007\024\r \026\027\024\030\036\022\021\ \026\035\034\027\024\005 \n\026\027\024\n\036\021\030\017\017 \(\f\235\017\ \027\022)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.133 Tw T* [(\021\036\030\024\n\036\021\030\017\016\) \023\024\r\024\035\016\036\021\ \r\t\016\r\017\021\034 \f\022\030\t\021\t\036 \027\026\030\031\001\036\027\ \017\016)-2( )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 606.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 45.2263 597.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (29)Tj ET endstream endobj 1584 0 obj [1589 0 R] endobj 1585 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 162.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 162.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 125.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 125.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-28-37)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 84.462 695.3259 Tm [(\210\002\t\r\n\025\t\017\020\200\t\217\004 \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 )]TJ -0.401 -1.105 Td [(\224\005\213\024\025\r\n\204\004\225\t\217\220 \016\b\n\234\004\221 \002\ \022)-23.3(\224\017\n\004\t\026)11(\025\b \016\022)-23.3(\255\025\020\004\212\t\200\206 \037)20(\005\025\t\017)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 649.822 Tm [(\f\t\025\016\025\b\022)-23.2(\030.\001.)]TJ 8.162 0 0 8.162 143.1654 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 147.8013 649.822 Tm [(, \240\005\217\204\025\b\017\022)-23.2(\032.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 235.4624 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 240.0983 649.822 Tm [(, \205\005\206\r\n\t\022)-23.2(\033)124(.\207.)]TJ 0 Tw 8.162 0 0 8.162 322.9016 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 327.5376 649.822 Tm [(, \210\025\024\004\t\r)10.1(\025\022)-23.3(\036.\207.)]TJ 0 Tw 8.162 0 0 8.162 425.5446 654.484 Tm (1)Tj 14 0 0 14 430.1806 649.822 Tm (, )Tj -25.665 -1.143 Td [(\201\004\t\n\016\004\t\r)10.1(\025\022)-23.3(\021.\035.)]TJ 8.162 0 0 8.162 160.889 638.484 Tm (2)Tj 0.023 Tw 14 0 0 14 165.525 633.822 Tm [(, \201\004\t\n\016\004\t\r)10.1(\025\022)-23.3(\211.\021.)]TJ 0 Tw 8.162 0 0 8.162 263.2238 638.484 Tm (2)Tj 0.023 Tw 14 0 0 14 267.8597 633.822 Tm [(, \235\017\r\037)20(\005\n\005\n\022)-23.2(\201.\235.\201.)]TJ 0 Tw 8.162 0 0 8.162 382.8069 638.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 619.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 616.1527 Tm [(\210\031\006)42(\227\253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-10(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 595.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 592.1527 Tm [(\227)31(\203 \253\021\n\026)11(\004\255\016\r\n\221 \025\255\020\017\016)-10(\026\t\025\221 \r)-10(\020\n\t\n\225\004\016\r\n\221 \016\224\004\n\017\020\n\212\n\005\025\b\ \017\t\t\217\221 \004\t\026\005\273 \(\002\020.\022)-23.3(\007\004\r\005\017\016\025\b\017, \202.\022)-23.3(1)75(0, \013)62(.\022)-23.3(\021\n\026)11(\004\255\016\r, )]TJ -0.331 -1.2 Td [(2)138(1)75(000)87(1)69(, \033\004\016\224\002\255\020\n\r\017 \006\004\020\017\005\002\016\200\)\ )]TJ /T1_0 1 Tf 0.216 Tw 9 0 0 9 119.0551 561.6488 Tm (\037\036\035\034: \031\006\027\025\022\023\017 \203\r\025\n\006\022\031\025\ \020\f\017\025\013\027 \032\027\016\r\f\017\023\020\023\013 \f\027\007\027\ \025\022\t \033\032\t\026\031\n\022\213\027\007\025\013\200 \024\021\022\ \212\027\235 \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\027\016\025\017\005 )Tj 0.023 Tw 0 -1.111 TD (\202\032\031\025\020 \(\221\202\).)Tj 0.018 Tw T* [(\004\003\037\002\036\001\201 )0.5(\002)]TJ /Span<>> BDC ( )Tj EMC 5.623 0 Td [(\215\036\217\220\201: )0.5(\033\032\031\021\027\030\027\025\031 )0.6(\032\027\023\032\031\024\033\027\n\023\022\021\025\031\027 )0.6(\022\024\024\f\027\030\031\021\020\025\022\027 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 22.743 0 Td [(\020\033\032\027\f\t )0.5(2018 )0.5(\033\031)]TJ /Span<>> BDC ( )Tj EMC 6.588 0 Td [(\024\027\025\023\t\240\032\017 2024 )0.5(\b\b., )0.5(\024\032\020\021)]TJ 0 Tw (-)Tj 0.106 Tw -34.954 -1.111 Td (\025\022\021\020\005\212\027\027 \203\r\025\n\006\022\005 \030\027\032\255\ \020\025\022\t \030\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\027\032\020\006\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\021 \031\023\030\020\f\233\025\025\031\026 \033\031\024\f\027\031\033\027\ \032\020\006\022\031\025\025\031\026 \033\027\032\022\031\030\027 \(\026\ \027\030\022\020\025\020 \025\020\240\f\005)Tj 0 Tw (-)Tj 0.095 Tw T* (\030\027\025\022\t \(Me\) 4,2 \026\027\024\t\006\020\) \r)Tj /Span<>> BDC ( )Tj EMC (150 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\022\020\025\020\f\017\025\013\026\022 \033\032\031\t\021\f\027\ \025\022\t\026\022 \240\031\f\027\016\025\022 \202\032\031\025\020 \(\004\ \004\221\202\). \214\r\025\n\006\022\t )Tj 0.112 Tw T* (\024\203\022\025\n\023\027\032\020 \030\031)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027 \031\033\027\032\020\006\022\022 \240\013\f\020 \031\006\ \027\025\027\025\020 \n\f\022\025\022\007\027\024\n\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \213\n\020\f\013 \ Wexner \022)Tj /Span<>> BDC ( )Tj EMC (\031\240\236\027\n\023\022\021\025\031 )Tj 0.045 Tw T* [(\026\027\023\031\030\031\026 )0.6(\024\203\022\025\n\023\027\032\031\026\027\023\032\022\022. )0.6(\220\f\t )0.5(\021\013\t\021\f\027\025\022\t )0.7(\203\020\n\023\031\032\031\021 )0.6(\032\022\024\n\020 )0.6(\n\f\022\025\022\007\027\024\n\031\235 )0.6(\001\003\205 )0.5(\033\032\031\021\027\030\027\025 )0.5(\031\030\025\031- )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 40.729 0 Td (\026\025\031\b\031\203\020\n)Tj 0 Tw (-)Tj 0.023 Tw -40.729 -1.111 Td (\023\031\032\025\013\235 \240\022\025\020\032\025\013\235 \f\031\b\022\024\ \023\022\007\027\024\n\022\235 \032\027\b\032\027\024\024\022\031\025\025\ \013\235 \020\025\020\f\022\016.)Tj 0.267 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \007\020\024\023\031\023\020 \n\f\022\ \025\022\007\027\024\n\031\235 \025\027\030\031\024\023\020\023\031\007\025\ \031\024\023\022 \020\025\020\f\017\025\031\b\031 \024\203\022\025\n\023\ \027\032\020 \(\001\003\205\) \(2 \022)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\027\027 \240\020\f\f\031\021 )Tj 0.027 Tw 0 -1.111 TD (\033\031)Tj /Span<>> BDC ( )Tj EMC (\213\n\020\f\027 Wexner\) \240\013\f\020 \031\006\027\025\027\025\020 \r\ )Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \240\027\016 \024\023\031\026\013 \022\ )Tj /Span<>> BDC ( )Tj EMC (\024\031\024\023\020\021\022\f\020 81/117 \(69%\))Tj /Span<>> BDC ( )Tj EMC (\227 \030\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\027\032\020\006\022\022, 83/117 )Tj 0.031 Tw T* (\(71%\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\031\024\f\027 \031\033\027\032\020\006\022\022, \016\025\020\007\ \022\026\013\200 \032\020\016\f\022\007\022\235 \033\031)Tj /Span<>> BDC ( )Tj EMC (\007\020\024\023\031\023\027 \021\013\t\021\f\027\025\031 \025\027 \240\013\ \f\031 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,84\). \217\030\025\020\n\031 \240\013\f\031 \031\023\026\027)Tj 0 Tw (-)Tj -0.029 Tw T* [(\007\027\025\031 )0.6(\024\023\020\023\022\024\023\022\007\027\024\n\022 )0.6(\016\025\020\007\022\026\031\027 )0.6(\r\021\027\f\022\007\027\025\022\027 )0.6(\n\031\f\022\007\027\024\023\021\020 )0.7(\240\020\f\f\031\021 )0.5(\033\031)]TJ /Span<>> BDC ( )Tj EMC 27.237 0 Td [(\213\n\020\f\027 )0.6(Wexner )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 6.454 0 Td [(\031\023\030\020\f\233\025\025\031\026 )0.5(\033\031\024\f\027\031\033\027\032\020\006\022)]TJ 0 Tw (-)Tj 0.026 Tw -33.691 -1.111 Td (\031\025\025\031\026 \033\027\032\022\031\030\027 \(\030\031 \031\033\027\ \032\020\006\022\022 \026\027\030\022\020\025\020 3 \(Q1;Q3 : 1;7\) \240\ \020\f\f\020, \033\031\024\f\027 \031\033\027\032\020\006\022\022 \026\027\ \030\022\020\025\020 5 \(Q1;Q3 : 1;9\) \240\020\f\f\031\021, )Tj 0.136 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\r\025\022\021\020\032\022\020\025\023\025\031\026 \020\025\020\f\022\016\ \027 \021\013\t\021\f\027\025\013 \203\020\n\023\031\032\013, \024\021\t\ \016\020\025\025\013\027 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\013\213\027\025\025\013\026 \032\022\024\n\031\026 \032\020\ \016\021\022\023\022\t )Tj 0.155 Tw T* [(\t\021\f\027\025\022\235 )0.5(\n\f\022\025\022\007\027\024\n\031\235 \001\003\205 \033\031\024\f\027 )0.5(\031\033\027\032\020\006\022\022: \030\f\022\023\027\f\017\025\031\024\023\ \017 )0.5(\020\025\020\026\025\027\016\020 )0.5(\033\027\032\022\020\025\020\f\017\025\013\200 \033\032\031\t\021\f\027\025\ \022\235 )0.5(\221\202 \(\031\023\025\031)]TJ 0 Tw (-)Tj 0.078 Tw T* (\213\027\025\022\027 \213\020\025\024\031\021 \(\217\237\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,17; 95% \030\031\021\027\032\022\023\027\f\017\025\013\235 \022\025\023\ \027\032\021\020\f \(\220\002\): 1,01\2311,38; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\), \031\033\027\032\020\006\022\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r )Tj -0.029 Tw T* (\024\021\022\212\027\235 \033\032\t\026\031\235 \n\022\213\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\026\025\027\016\027 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,33; 95% \220\002: 0,15\2310,75; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\), \n\031\f\022\007\027\024\023\021\031 \031\033\027\032\020\006\022\ \235 \021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\026\025\027\016\027 )Tj 0.114 Tw 0 -1.111 TD (\(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,16; 95% \220\002: 1,01\2314,6; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,046\), \021)Tj /Span<>> BDC ( )Tj EMC [(\023\031\026 \007\022\024\f\027 \n\031\f\022\007\027\024\023\021\031 )0.5(\021\024\n\032\013\023\022\235 \033\020\032\020\033\032\031\n\023\022\023\ \020 \(\217\237)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,85; )Tj 0.026 Tw 0 -1.111 TD (95% \220\002: 1,12\2313,08, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,017\), \n\031\f\022\007\027\024\023\021\031 \024\021\022\212\027\235 \033\ \032\t\026\031\235 \n\022\213\n\022 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,25; 95% \220\002: 1,04\2314,87; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,039\). )Tj -0.012 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\023\031 \255\027 \021\032\027\026\t, \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\b\031\203\020\n\023\031\032\025\031\026 \020\025\020\f\022\016\ \027 \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\ \022\026\031\b\031 \021\f\022\t\025\022\t \021\013\213\027\r\n\020\016\020\ \025\025\013\200 \203\020\n\023\031\032\031\021 )Tj 0.168 Tw T* (\025\027 \033\031\030\023\021\027\032\030\022\f\031\024\017. \232\020\024\ \023\031\023\020 \001\003\205 \021)Tj /Span<>> BDC ( )Tj EMC (\024\031\031\023\021\027\023\024\023\021\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026\022 \024\203\022\025\n\023\027\032\031\026\027\023\ \032\022\022 \030\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\027\032\020\006\022\022 \031\023\026\027\007\027\025\020 )Tj 0.066 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (120/150 \(80%\) \033\020\006\022\027\025\023\031\021, \033\031\024\f\027\ )Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (137/150 \(91%\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0004\). \210)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024 \022\024\200\031\030\025\031 \025\ \031\032\026\020\f\017\025\013\026\022 )Tj 0.05 Tw T* (\026\020\025\031\026\027\023\032\022\007\027\024\n\022\026\022 \033\031\n\ \020\016\020\023\027\f\t\026\022 \030\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\027\032\020\006\022\022 \240\013\f\020 \021\013\213\027 \007\020\ \024\023\031\023\020 \032\020\016\021\022\023\022\t \t\021\f\027\025\022\ \235 \020\025\020\f\017\025\031\235 \022\025\n\031\025\023\022)Tj 0 Tw (-)Tj 0.003 Tw T* (\025\027\025\006\022\022 \033\031\024\f\027 \031\033\027\032\020\006\022\ \022 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \205\032\027\030\025\027\027 \030\020\021\f\027\025\022\027 \021\ )Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\031\026 \n\020\025\020\f\027 \021)Tj /Span<>> BDC ( )Tj EMC (\033\031\n\031\027 \(\205\220 \003\202\033\) \022\024\200\031\030\025\031\ \240\013\f\031 \025\022\255\027 )Tj 0.077 Tw T* [(\032\027\203\027\032\027\025\024\025\013\200 )0.5(\016\025\020\007\027\025\022\235 )0.6(\021)]TJ /Span<>> BDC ( )Tj EMC (116)Tj /Span<>> BDC ( )Tj EMC 12.376 0 Td [(\(77%\) )0.5(\024\f\r\007\020\t\200, )0.5(\033\031\024\f\027 )0.5(\031\033\027\032\020\006\022\022)]TJ /Span<>> BDC ( )Tj EMC 13.364 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (137)Tj /Span<>> BDC ( )Tj EMC 3.857 0 Td [(\(91%\), \007\023\031 )0.5(\024\021\022\030\027\023\027\f\017\024\023\021\r\027\023 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 13.754 0 Td (\024\025\022)Tj 0 Tw (-)Tj 0.036 Tw -43.35 -1.111 Td [(\255\027\025\022\022 )0.5(\030\020\025\025\031\b\031 \033\031\n\020\016\020\023\027\f\t )0.5(\033\031\024\f\027 )0.5(\031\033\027\032\020\006\022\022 \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,001\). \214\020\n\023\031\032\031\021, )0.5(\033\032\027\030\032\020\024\033\031\f\020\b\020\005\212\022\200 \n)]TJ /Span<>> BDC ( )Tj EMC 37.555 0 Td (\033\031\021\013\213\027\025\022\005 \032\022\024\n\020 )Tj 0.023 Tw -37.555 -1.111 Td (\032\020\016\021\022\023\022\t \031\240\236\027\n\023\022\021\025\031\235\ \001\003\205, \025\027 \021\013\t\021\f\027\025\031.)Tj 0.057 Tw T* (\207\003\202\035\224\232\036\001\002\036: \033\020\006\022\027\025\023\013\ \024\031 \024\f\031\255\025\013\026\022 \033\032\t\026\031\n\022\213\027\ \007\025\013\026\022 \024\021\022\212\020\026\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\027\016\025\022 \202\032\031\025\020 \033\032\027\030\024\023\ \020\021\f\t\005\023 \024\031\240\031\235 )Tj -0.006 Tw T* (\n\032\020\235\025\027 \024\f\031\255\025\r\005 \n\031\b\031\032\023\r \240\ \031\f\017\025\013\200, \021)Tj /Span<>> BDC ( )Tj EMC (\023\031\026 \007\022\024\f\027 \021\024\f\027\030\024\023\021\022\027 \021\ \013\024\031\n\031\b\031 \032\022\024\n\020 \032\020\016\021\022\023\022\ \t \t\021\f\027\025\022\235 \033\031\024\f\027\031\033\027\032\020\006\022\ )Tj 0 Tw (-)Tj 0.031 Tw T* (\031\025\025\031\235 \020\025\020\f\017\025\031\235 \022\025\n\031\025\023\ \022\025\027\025\006\022\022. \001\027\031\240\200\031\030\022\026\031 \033\ \032\022\026\027\025\027\025\022\027 \022\025\030\022\021\022\030\r\020\f\ \017\025\031\b\031 \033\031\030\200\031\030\020 \021)Tj /Span<>> BDC ( )Tj EMC (\031\023\025\031\213\027\025\022\022 \023\020\n\023\022\n\022 )Tj 0.067 Tw T* [(\031\033\027\032\020\023\022\021\025\031\b\031 )0.6(\021\026\027\213\020\023\027\f\017\024\023\021\020, )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 14.25 0 Td [(\r\007\233\023\031\026 )0.5(\020\025\020\026\025\027\016\020 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 8.36 0 Td [(\023\027\n\r\212\027\b\031 )0.5(\024\031\024\023\031\t\025\022\t \033\020\006\022\027\025\023\020, )0.5(\020)]TJ /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \031\240\024\r\255\030\027\025\022\027 )Tj 0.124 Tw -22.61 -1.111 Td (\025\020)Tj /Span<>> BDC ( )Tj EMC [(\030\031\031\033\027\032\020\006\022\031\025\025\031\026 \204\023\020\033\ \027 \021\027\032\031\t\023\025\031\024\023\022 )0.5(\024\025\022\255\027\025\022\t \203\r\025\n\006\022\022 \020\025\020\f\017\ \025\031\b\031 \024\203\022\025\n\023\027\032\020 \033\031\024\f\027 \031\ \033\027\032\020\006\022\022, \021)]TJ /Span<>> BDC ( )Tj EMC (\023\031\026 )Tj 0.097 Tw T* (\007\022\024\f\027 \024)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\026\031\255\025\031\235 \025\027\031\240\200\031\030\022\026\ \031\024\023\017\005 \027\b\031 \030\020\f\017\025\027\235\213\027\235 \200\ \022\032\r\032\b\022\007\027\024\n\031\235 \n\031\032\032\027\n\006\022\022\ . \002\016\r\007\020\027\026\020\t \033\032\031\240\f\027\026\020 \031\024\ \023\020)Tj 0 Tw (-)Tj 0.076 Tw T* (\027\023\024\t \031\023\n\032\013\023\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\023\032\027\240\r\027\023 \033\032\031\021\027\030\027\025\022\t \030\020\ \f\017\025\027\235\213\022\200 \022\024\024\f\027\030\031\021\020\025\022\ \235, \033\031\024\021\t\212\027\025\025\013\200 \n\020\n \024\r\240\236\ \027\n\023\022\021\025\031\235 \031\006\027\025\n\027 )Tj 0.027 Tw 0 -1.111 TD (\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 \024\031\024\023\031\ \t\025\022\t \016\020\033\022\032\020\023\027\f\017\025\031\b\031 \020\033\ \033\020\032\020\023\020 \033\032\t\026\031\235 \n\022\213\n\022, \023\020\ \n \022)Tj /Span<>> BDC ( )Tj EMC (\022\025\024\023\032\r\026\027\025\023\020\f\017\025\013\026 \026\027\023\ \031\030\020\026 )Tj 0.023 Tw 0 -1.111 TD (\027\b\031 \030\022\020\b\025\031\024\023\022\n\022.)Tj /T1_2 1 Tf 0.01 Tc 0.013 Tw 8 0 0 8 70.906 196.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.018 Tw 8.488 0 Td ( \240\031\f\027\016\025\017 \202\032\031\025\020, \025\027\030\031\024\023\ \020\023\031\007\025\031\024\023\017 \020\025\020\f\017\025\031\b\031 \024\ \203\022\025\n\023\027\032\020, \020\025\020\f\017\025\020\t \022\025\n\031\ \025\023\022\025\027\025\006\022\t, \024\203\022\025\n\023\027\032\031\026\ \027\023\032\022\t, \033\027\032\022\020\025\020\f\017)Tj 0 Tw (-)Tj 0.023 Tw -8.493 -1.2 Td (\025\013\027 \033\031\032\020\255\027\025\022\t \240\031\f\027\016\025\022\ \202\032\031\025\020, \004\004\221\202)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.033 Tc 0.06 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.065 Tw 9.232 0 Td ( \202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\222., \213\030\t\001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\224., \205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\224., \212\036\027\017\f\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\214., \212\036\027\017\f\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\233.\200., \204\026\022\025\030\017\030\017)Tj /Span<>> BDC ( )Tj EMC [(\212.\204.\212.)23( )]TJ 0.031 Tw -9.237 -1.2 Td (\205\031\027\022\006\017\024\027\026\035\034\027\t\036 \030\036\031\035\ \034\021\026\021\t \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \ \035\036\004\036\027\017\016 \023\030\016\n\024\022\017\001\036\004\027\t\ \b \f\r\017\013\036\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\034\033 \025\030\024\027\026. )Tj /T1_0 1 Tf -0.023 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (28\22637. https://doi.org/10.33878/2073-7556-2026-25-1-28-37)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 570.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 76.0071 561.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.1276 56.0378 Tm (28)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 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car)31.1(cinoma)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.213 Tw 8 0 0 8 42.5197 711.9952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Dav)-16(id P)40(a)15(tr)-36.9(ick Cyr, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Outcomes of)Tj /Span<>> BDC ( )Tj EMC [(sal)30(v)-15(a)-17(ge sur)-32(ger)-23.9(y for anal )]TJ 0.184 Tw -1.296 -1.25 Td [(squamous cell car)-32(c)-24(inoma: A)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and me)-11.9(t)15(a-anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0 Tw 0 -1.25 TD [(JC)21(O.)]TJ /T1_2 1 Tf 0.023 Tw [( 2019;37, 3571-3571. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1200/JC)13(O.2019.37.15_suppl.3571)]TJ 0 0 0 1 k /GS1 gs 0.331 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gunder)-10(son)]TJ /Span<>> BDC ( )Tj EMC 4.838 0 Td [(LL, W)-15.9(inter)]TJ /Span<>> BDC ( )Tj EMC [(KA, )0.5(Ajani)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)35(ong-ter)-16(m upd)42(a)15(te )]TJ 0.077 Tw -6.134 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(US GI inter)-31.9(gr)-32(oup R)-12(T)20(OG 98\22611)]TJ /Span<>> BDC ( )Tj EMC [(phase III tr)-37(ial for anal car)-32(c)-24(inoma: )]TJ 0.195 Tw T* [(sur)-32(v)-16(i)-15.9(v)-15(al, r)-24(el)-16(apse, and col)30(ost)17.1(omy f)16(ail)35(ur)-24(e wi)-24(t)-13(h concur)-23.9(r)-24(ent chemor)-33(a)]TJ 0 Tw (-)Tj 0.347 Tw T* [(dia)15(t)-32(ion invol)30(v)-15.9(ing fl)35.1(uor)-32(our)-33(a)-17(c)-24(il/mi)-23.9(t)17(omyc)-24(in ver)-9.9(sus fl)35.1(uor)-32(our)-33(a)-17(c)-24(il/c)-23.9(is)]TJ 0 Tw (-)Tj T* [(pl)-16(a)15(t)-32(in. )]TJ /T1_3 1 Tf 0.217 Tw 3.153 0 Td (J Clin Oncol.)Tj /T1_2 1 Tf [( 2012 Dec 10;30\(35\):4344\22651. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1200/)Tj -3.153 -1.25 Td [(JC)13(O.2012.43.8085)]TJ 0 0 0 1 k /GS1 gs 0.318 Tw [( Epub 2012 N)-13.9(ov 13. PMID: 23150707; PMCID: )]TJ 0 Tw T* (PMC3515768.)Tj 0.067 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (James)Tj /Span<>> BDC ( )Tj EMC [(RD, Gl)35(ynne-Jones)]TJ /Span<>> BDC ( )Tj EMC [(R, Mead)-16(o)-14(ws)]TJ /Span<>> BDC ( )Tj EMC [(HM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mi)-24(t)17(omyc)-23.9(in or c)-24(is)]TJ 0 Tw (-)Tj 0.118 Tw -1.296 -1.25 Td [(pl)-16(a)15(t)-32(in chemor)-33(adia)15.1(t)-32(ion wi)-23.9(t)-13(h or wi)-23.9(t)-13(hout maintenance chemo)17(t)-13(her)-32.9(apy )]TJ -0.025 Tw T* [(for )0.5(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(squamous-cell )0.5(car)-32(c)-24(inoma )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )0.5(anus )0.5(\(A)16(CT II\): )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(an)]TJ 0 Tw (-)Tj 0.004 Tw T* [(d)-16(omised, phase 3, open-l)-15.9(abel, 2)]TJ /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC [(2 f)16(a)-17(c)-16(t)17(or)-36.9(ial tr)-37(ial. )]TJ /T1_3 1 Tf (Lancet Oncol.)Tj /T1_2 1 Tf ( 2013 )Tj 0.012 Tc 0.434 Tw T* [(Ma)15.2(y;14\(6\):516\22624. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.012 Tw (10.1016/S1470-2045\(13\)70086-X)Tj 0 0 0 1 k /GS1 gs 0.434 Tw [( Epub)11.9( )]TJ 0 Tc 0.023 Tw T* [(2013 Ap)25(r 9. PMID: 23578724)]TJ 0.078 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\206\024\030\007\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\222., \205\036\007\016\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\224., \206\035\026\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \217\024\035\034 \021\036\035\036)Tj 0 Tw (-)Tj 0.127 Tw -1.296 -1.25 Td (\n\036\007\017\006\017\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\036\007\022\017\b \026\002\024\035\036\ \r\026\027\017\005: \026\027\026\035\017 1 \020\024\007\026 \030\026\002\ \024\021\t )Tj 0.015 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\030\036 \030\026\022\026 \026\027\026\035\034\027\024\ \020\024 \022\026\027\026\035\026. )Tj /T1_3 1 Tf (\020\016\031\021\020\t \200\022\032\r\032\b\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\025\n\031\f\031\b\022\t.)Tj /T1_2 1 Tf 0 Tw ( )Tj T* (2020;10\(2\):28\22632.)Tj 0.165 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gond)42(al)]TJ /Span<>> BDC ( )Tj EMC [(T)35(A, Chaudhar)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(N, Bajw)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal Cancer: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(P)40(ast, )]TJ 0.347 Tw -1.296 -1.25 Td [(P)35(r)-24(esent and F)10(utur)-24(e. )]TJ /T1_3 1 Tf [(Cur)-16(r Oncol.)]TJ /T1_2 1 Tf ( 2023 Mar 11;30\(3\):3232\2263250. )Tj 0.02 Tc -0.02 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.647 0 Td [(10.3390/cur)-24(r)-32(oncol30030246)]TJ 0 0 0 1 k /GS1 gs 0.724 Tw [( )0.6(PMID: )0.5(36975459; )0.5(PMCID:)20( )]TJ 0 Tc 0 Tw -2.647 -1.25 Td (PMC10047250.)Tj 0.063 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\206\024\030\007\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\222., \204\026\n\036\007\035\017)Tj /Span<>> BDC ( )Tj EMC (\003.\003., \232\036\030\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 )Tj 0.243 Tw -1.296 -1.25 Td (\030\036\022\024\n\036\027\007\026\006\017\017 \204\003 \217\205 \253\215\ \035\024\f\022\024\022\035\036\021\024\004\027\t\005 \030\026\022 \026\027\ \026\035\034\027\024\020\024 \022\026\027\026\035\026, )Tj 0.14 Tw T* [(\026\027\026\035\034\027\024\020\024 \022\030\026\016, \023\036\030\017\026\ \027\026\035\034\027\024\005 \022\024\032\017\273. 2025; ht)-29.9(tps://cr.minzdr)-32.9(av.)]TJ 0 Tw T* [(gov.r)-21.9(u/v)-16(iew-cr/555_3)]TJ 0.017 Tc 0.628 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.348 0 Td (\232\036\030\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \211\005\n\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \025\031\030\036\027\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17.1( )]TJ 0 Tc -0.007 Tw -1.348 -1.25 Td (\212\017\f\021\026\027\006\017\024\027\027\026\016 \035\031\004\036\r\026\ \016 \021\036\030\026\023\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\f\022\024\022\035\036\021\024\004\027\024\n \030\026\022\036\ \026\027\026\035\034)Tj 0 Tw (-)Tj 0.001 Tc 0.35 Tw 29.055 36.25 Td [(\027\024\020\024 \022\026\027\026\035\026: \023\024\007\020\024\021\024\r\ \022\026, \023\035\026\027\017\030\024\r\026\027\017\036, \027\033\026\027\ \f\t \035\036\004\036\027\017\016. \204.:)1.1( )]TJ 0 Tc 0.238 Tw T* [(\205\206\207\211 )0.6(\253\203\204\230\037 )0.6(\024\027\022\024\035\024\020\017\017 )0.6(\017\n. )0.6(\203.\203.)]TJ /Span<>> BDC ( )Tj EMC 15.014 0 Td [(\207\035\024\b\017\027\026\273 )0.6(\204\017\027\007\030\026\r\026 )0.6(\217\024\f\f\017\017. )]TJ 0.023 Tw -15.014 -1.25 Td (2024; 52 \f.)Tj 0.151 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cor)-24(r)-23.9(ea)]TJ /Span<>> BDC ( )Tj EMC 2.958 0 Td [(JH, )0.6(Castr)-32(o)]TJ /Span<>> BDC ( )Tj EMC 4.532 0 Td [(LS, )0.6(K)25(esle)-11(y)]TJ /Span<>> BDC ( )Tj EMC 4.39 0 Td [(R, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.31 0 Td [(al. )0.6(Sal)30(v)-15(a)-17(ge )0.5(abd)-15.9(ominoper)-37(ineal )]TJ -0.002 Tw -15.486 -1.25 Td [(r)-24(esec)-15.9(t)-32(ion for anal cancer foll)30(o)-14(wing chemor)-33(adia)15(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(oposed scor)]TJ 0 Tw 27.286 0 Td (-)Tj 0.047 Tw -27.286 -1.25 Td [(ing sy)-13(stem for p)25(r)-24(edic)-16(t)-32(ing post)17(oper)-32.9(a)15(t)-32(i)-16(ve sur)-32(v)-16(i)-16(v)-15(al. )]TJ /T1_3 1 Tf (J Surg Oncol)Tj /T1_2 1 Tf (. 2013 )Tj -0.012 Tw T* [(Ap)25(r;107\(5\):486\22692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/jso.23283)Tj 0 0 0 1 k /GS1 gs -0.012 Tw [( Epub 2012 N)-13.9(ov 5. PMID: )]TJ 0 Tw T* (23129564.)Tj 0.087 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Al)-16(amr)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC 2.963 0 Td [(Y, )0.6(Buchw)-12(ald)]TJ /Span<>> BDC ( )Tj EMC 5.189 0 Td [(P, )0.6(Dix)10(on)]TJ /Span<>> BDC ( )Tj EMC 3.623 0 Td [(L, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.099 0 Td [(al. )0.6(Sal)30(v)-15(a)-17(ge )0.5(sur)-31.9(ger)-24(y )0.5(in )0.6(p)32(a)15(t)-32(ients )]TJ 0.22 Tw -15.17 -1.25 Td [(wi)-24(t)-12.9(h r)-24(ecur)-23.9(r)-24(ent or r)-23.9(esidual squamous )0.5(cell car)-31.9(c)-24(inoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he anus. )]TJ /T1_3 1 Tf 0.346 Tw T* [(Eur J )0.5(Surg Oncol.)]TJ /T1_2 1 Tf [( 2016 N)-14(ov;42\(11\):1687\2261692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ejso.2016.05.006)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2016 Ma)15(y 25. PMID: 27241923.)]TJ 0.01 Tc 0.383 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.837 0 Td (\200\024\030\024\002\034\036\r)Tj /Span<>> BDC ( )Tj EMC (\206.\230., \231\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \203\036\004\031\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\230., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0.011 Tc 0.418 Tw -1.837 -1.25 Td [(\217\036\031\035\034\021\026\021\t \b\017\030\031\030\020\017\004\036\f\ \022\024\020\024 \035\036\004\036\027\017\016 \002\024\035\034\027\t\b \030\ \036\017\007\031\026\035\034\027\t\n\017)11( )]TJ 0 Tc 0.174 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\027\t\n\017 \024\023\031\b\024\035\016\n\017 \ \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026. )Tj /T1_3 1 Tf (\225\022\032\r\032\b\022\t. \234\r\032\025\020\f )Tj 0.023 Tw T* (\022\026. \001.\002.)Tj /Span<>> BDC ( )Tj EMC (\004\022\032\031\b\031\021\020)Tj /T1_2 1 Tf (. 2008\(8\):4\2269.)Tj 0.013 Tc 0.481 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.848 0 Td [(Ha)-17.1(gemans)]TJ /Span<>> BDC ( )Tj EMC [(J)14.9(A)26.9(W, Bl)-31.1(inde)]TJ /Span<>> BDC ( )Tj EMC [(SE, Nuy)-16.1(t)-30.1(tens)]TJ /Span<>> BDC ( )Tj EMC [(JJ, e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sal)29.9(v)-15.1(a)-17(ge)13( )]TJ 0.46 Tw -1.848 -1.25 Td [(A)-13.5(b)0.5(d)-15.4(o)0.5(m)0.5(i)0.5(n)0.5(o)0.5(p)0.5(e)0.5(r)-36.4(i)0.5(n)0.5(e)0.5(a)0.5(l)0.5( R)13.5(e)0.5(s)0.5(e)0.5(c)-15.5(t)-31.5(i)0.6(o)0.5(n)0.5( f)0.5(o)0.5(r)0.6( S)0.5(q)0.5(u)0.5(a)0.5(m)0.6(o)0.5(u)0.5(s)0.5( C)0.5(e)0.5(l)0.6(l)0.5( A)0.5(n)0.5(a)0.6(l)0.5( C)0.5(a)0.5(n)0.5(c)0.5(e)0.5(r)0.6(:)13( )]TJ 0.003 Tc 0.349 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(30-Y)30.4(ear)0.5( S)-15.6(ingl)0.5(e-Ins)0.5(t)-31.6(i)-23.6(tut)-31.6(i)0.5(on E)35.4(x)0.5(per)-36.6(ien)0.5(ce. )]TJ /T1_3 1 Tf [(A)0.5(nn)0.5( Surg)0.5( Onco)0.5(l.)]TJ /T1_2 1 Tf [( 201)0.5(8)3( )]TJ 0 Tc 0.125 Tw T* [(Jul;25\(7\):1970\2261979. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1245/s10434-018-6483-9)Tj 0 0 0 1 k /GS1 gs 0.125 Tw ( Epub 2018 )Tj 0.023 Tw T* [(Ap)25(r 24. PMID: 29691737; PMCID: PMC5976705.)]TJ 0.01 Tc 0.371 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td [(Guer)-23.9(r)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(GR, K)25.1(ong)]TJ /Span<>> BDC ( )Tj EMC [(JC, Ber)-14.9(nar)-23.9(di)]TJ /Span<>> BDC ( )Tj EMC [(MP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sal)30.1(v)-15(a)-16.9(ge Sur)-31.9(ger)-23.9(y)10( )]TJ 0.003 Tc 0.35 Tw -1.836 -1.25 Td [(for )0.5(L)35.1(o)-16(cor)-24(egional )0.5(F)20.1(ail)35(ur)-23.9(e )0.6(in )0.5(Anal )0.6(Squamous )0.5(Cell )0.6(Car)-32(c)-23.9(inoma. )]TJ /T1_3 1 Tf -0.003 Tw 26.461 0 Td [(Dis)3.1( )]TJ 0.025 Tc 0.896 Tw -26.461 -1.25 Td [(Colon R)21.1(ectum)]TJ /T1_2 1 Tf [(. 2018 F)10.1(eb;61\(2\):179\226186. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.025 Tw (10.1097/)Tj 0 Tc 0 Tw T* (DCR.0000000000001010)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 29337772.)Tj 0.111 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(osen)]TJ /Span<>> BDC ( )Tj EMC [(R, Q)-16(uezad)42(a-Dia)-24(z)]TJ /Span<>> BDC ( )Tj EMC (FF, G\366nen)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oncol)30(o)-15.9(gic Outcomes )]TJ 0.331 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Sal)30.1(v)-15(a)-17(ge A)-14(bd)-16(ominoper)-37(ineal R)13(esec)-16(t)-32(ion for Anal Squamous Cell )]TJ 0.055 Tw T* [(Car)-32(c)-24(inoma Ini)-24(t)-32(iall)35.1(y Mana)-17(ged wi)-23.9(t)-13(h Chemor)-32.9(adia)15(t)-32(ion. )]TJ /T1_3 1 Tf (J Clin Med. )Tj /T1_2 1 Tf 0 Tw (2024 )Tj 0.005 Tc 0.349 Tw T* [(A)0.6(p)25.5(r)0.5( 9)0.5(;)0.6(1)0.5(3)0.6(\()0.5(8)0.6(\))0.5(:)0.5(2)0.6(1)0.5(5)0.6(6)0.5(.)0.5( d)-15.4(o)0.5(i)0.5(:)]TJ /Span<>> BDC 9.843 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw [(1)0.5(0)0.5(.)0.6(3)0.5(3)0.6(9)0.5(0)0.5(/)0.6(j)0.5(c)0.6(m)0.5(1)0.5(3)0.6(0)0.5(8)0.6(2)0.5(1)0.5(5)0.6(6)]TJ 0 0 0 1 k /GS1 gs 0.349 Tw 9.848 0 Td [( P)0.5(M)0.6(I)0.5(D)0.5(:)0.6( 3)0.5(8)0.5(6)0.6(7)0.5(3)0.6(4)0.5(2)0.5(9)0.6(;)5( )]TJ 0 Tc 0.023 Tw -19.691 -1.25 Td (PMCID: PMC11050212.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 396.0239 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.213 Tw 8 0 0 8 42.5197 383.1892 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Dav)-16(id P)40(a)15(tr)-36.9(ick Cyr, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Outcomes of)Tj /Span<>> BDC ( )Tj EMC [(sal)30(v)-15(a)-17(ge sur)-32(ger)-23.9(y for anal )]TJ 0.184 Tw -1.296 -1.25 Td [(squamous cell car)-32(c)-24(inoma: A)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and me)-11.9(t)15(a-anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0 Tw T* [(JC)21(O.)]TJ /T1_2 1 Tf 0.023 Tw [( 2019;37, 3571-3571. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1200/JC)13(O.2019.37.15_suppl.3571)]TJ 0 0 0 1 k /GS1 gs 0.331 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gunder)-10(son)]TJ /Span<>> BDC ( )Tj EMC 4.838 0 Td [(LL, W)-15.9(inter)]TJ /Span<>> BDC ( )Tj EMC [(KA, )0.5(Ajani)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)35(ong-ter)-16(m upd)42(a)15(te )]TJ 0.077 Tw -6.134 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(US GI inter)-31.9(gr)-32(oup R)-12(T)20(OG 98\22611)]TJ /Span<>> BDC ( )Tj EMC [(phase III tr)-37(ial for anal car)-32(c)-24(inoma: )]TJ 0.195 Tw T* [(sur)-32(v)-16(i)-15.9(v)-15(al, r)-24(el)-16(apse, and col)30(ost)17.1(omy f)16(ail)35(ur)-24(e wi)-24(t)-13(h concur)-23.9(r)-24(ent chemor)-33(a)]TJ 0 Tw (-)Tj 0.347 Tw T* [(dia)15(t)-32(ion invol)30(v)-15.9(ing fl)35.1(uor)-32(our)-33(a)-17(c)-24(il/mi)-23.9(t)17(omyc)-24(in ver)-9.9(sus fl)35.1(uor)-32(our)-33(a)-17(c)-24(il/c)-23.9(is)]TJ 0 Tw (-)Tj T* [(pl)-16(a)15(t)-32(in. )]TJ /T1_3 1 Tf 0.217 Tw 3.153 0 Td (J Clin Oncol.)Tj /T1_2 1 Tf [( 2012 Dec 10;30\(35\):4344\22651. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1200/)Tj -3.153 -1.25 Td [(JC)13(O.2012.43.8085)]TJ 0 0 0 1 k /GS1 gs 0.318 Tw [( Epub 2012 N)-13.9(ov 13. PMID: 23150707; PMCID: )]TJ 0 Tw T* (PMC3515768.)Tj 0.067 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (James)Tj /Span<>> BDC ( )Tj EMC [(RD, Gl)35(ynne-Jones)]TJ /Span<>> BDC ( )Tj EMC [(R, Mead)-16(o)-14(ws)]TJ /Span<>> BDC ( )Tj EMC [(HM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mi)-24(t)17(omyc)-23.9(in or c)-24(is)]TJ 0 Tw (-)Tj 0.118 Tw -1.296 -1.25 Td [(pl)-16(a)15(t)-32(in chemor)-33(adia)15.1(t)-32(ion wi)-23.9(t)-13(h or wi)-23.9(t)-13(hout maintenance chemo)17(t)-13(her)-32.9(apy )]TJ -0.025 Tw T* [(for )0.5(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(squamous-cell )0.5(car)-32(c)-24(inoma )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )0.5(anus )0.5(\(A)16(CT II\): )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(an)]TJ 0 Tw (-)Tj 0.004 Tw T* [(d)-16(omised, phase 3, open-l)-15.9(abel, 2)]TJ /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC [(2 f)16(a)-17(c)-16(t)17(or)-36.9(ial tr)-37(ial. )]TJ /T1_3 1 Tf (Lancet Oncol.)Tj /T1_2 1 Tf ( 2013 )Tj 0.012 Tc 0.434 Tw T* [(Ma)15.2(y;14\(6\):516\22624. d)-15.8(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.012 Tw (10.1016/S1470-2045\(13\)70086-X)Tj 0 0 0 1 k /GS1 gs 0.434 Tw [( Epub)11.9( )]TJ 0 Tc 0.023 Tw T* [(2013 Ap)25(r 9. PMID: 23578724)]TJ -0.022 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gor)-24(deev)]TJ /Span<>> BDC ( )Tj EMC 3.465 0 Td [(S.S., F)10(ed)17(y)22(anin)]TJ /Span<>> BDC ( )Tj EMC [(M. Y)35.1(u., Gl)-16(a)-24(zkov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.V., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (tele)Tj 0 Tw (-)Tj 0.18 Tw -4.761 -1.25 Td [(medic)-24(ine )0.6(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 7.079 0 Td [(tr)-24(ea)15(tment )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.657 0 Td [(r)-33(ar)-23.9(e )0.5(diseases: )0.6(an)]TJ /Span<>> BDC ( )Tj EMC 7.475 0 Td [(anal)35(y)-13(sis )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.824 0 Td [(1 )0.5(year )]TJ 0.057 Tw -25.035 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(w)-14(or)-23.9(k on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(x)-10.9(am)10(ple of)]TJ /Span<>> BDC ( )Tj EMC (anal cancer. )Tj /T1_3 1 Tf [(P)15(elvic Surg)12(er)-42.9(y and Oncology)]TJ /T1_2 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2020;10\(2\):28\22632. \(in Russ.\).)Tj 0.165 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gond)42(al)]TJ /Span<>> BDC ( )Tj EMC [(T)35(A, Chaudhar)-24(y)]TJ /Span<>> BDC ( )Tj EMC [(N, Bajw)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anal Cancer: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(P)40(ast, )]TJ 0.347 Tw -1.296 -1.25 Td [(P)35(r)-24(esent and F)10(utur)-24(e. )]TJ /T1_3 1 Tf [(Cur)-16(r Oncol.)]TJ /T1_2 1 Tf ( 2023 Mar 11;30\(3\):3232\2263250. )Tj 0.02 Tc -0.02 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.647 0 Td [(10.3390/cur)-24(r)-32(oncol30030246)]TJ 0 0 0 1 k /GS1 gs 0.724 Tw [( )0.6(PMID: )0.5(36975459; )0.5(PMCID:)20( )]TJ 0 Tc 0 Tw -2.647 -1.25 Td (PMC10047250.)Tj 0.158 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gor)-24(deev)]TJ /Span<>> BDC ( )Tj EMC [(S.S., Mammedl)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(Z.Z., Cher)-15(nykh)]TJ /Span<>> BDC ( )Tj EMC [(M.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-30.9(inical r)-24(ec)]TJ 0 Tw (-)Tj 0.131 Tw -1.296 -1.25 Td [(ommend)42(a)15(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Ministr)-23.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(Heal)56(t)-12.9(h of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Russian F)10(eder)-32.9(a)15(t)-32(ion )]TJ 0.342 Tw T* [(\236Squamous )0.6(cell )0.6(car)-32(c)-24(inoma )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 13.185 0 Td [(t)-13(he )0.6(anal )0.5(canal, )0.6(anal )0.6(mar)-32(gin, )0.5(and )]TJ 0.07 Tw -13.185 -1.25 Td [(per)-37(ianal sk)-16(in\237. 2025; ht)-30(tps://cr.minzdr)-32.9(av.gov.r)-21.9(u/v)-15.9(iew-cr/555_3 \(in )]TJ 0 Tw T* (Russ.\).)Tj 0.028 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cher)-15(nykh)]TJ /Span<>> BDC ( )Tj EMC (M.V., Uymanov)Tj /Span<>> BDC ( )Tj EMC [(V.A., K)25(ur)-23.9(enkov)]TJ /Span<>> BDC ( )Tj EMC [(D.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(emo)17(te r)-32.9(adia)]TJ 0 Tw (-)Tj 0.092 Tw -1.296 -1.25 Td [(t)-32(ion t)-13(her)-32.9(apy for squamous cell car)-32(c)-24(inoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he anal canal: p)25(r)-24(ep)32(a)]TJ 0 Tw (-)Tj 0.172 Tw 29.055 37.5 Td [(r)-33(a)15(t)-32(ion, pl)-15.9(anning, nuances of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment. M)-24(osco)-14(w: Bl)30(okhin Na)15(t)-31.9(ional )]TJ 0.302 Tw T* [(R)13(esear)-32(ch Medical Center of)]TJ /Span<>> BDC ( )Tj EMC [(Oncol)30(o)-16(g)16(y, Ministr)-24(y of)]TJ /Span<>> BDC ( )Tj EMC [(Heal)56(t)-13(h of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.023 Tw T* [(Russian F)10.1(eder)-33(a)15(t)-32(ion. 2024; 52 p. \(in Russ.\).)]TJ 0.151 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cor)-24(r)-23.9(ea)]TJ /Span<>> BDC ( )Tj EMC 2.958 0 Td [(JH, )0.6(Castr)-32(o)]TJ /Span<>> BDC ( )Tj EMC 4.532 0 Td [(LS, )0.6(K)25(esle)-11(y)]TJ /Span<>> BDC ( )Tj EMC 4.39 0 Td [(R, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.31 0 Td [(al. )0.6(Sal)30(v)-15(a)-17(ge )0.5(abd)-15.9(ominoper)-37(ineal )]TJ -0.002 Tw -15.486 -1.25 Td [(r)-24(esec)-15.9(t)-32(ion for anal cancer foll)30(o)-14(wing chemor)-33(adia)15(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(oposed scor)]TJ 0 Tw 27.286 0 Td (-)Tj 0.047 Tw -27.286 -1.25 Td [(ing sy)-13(stem for p)25(r)-24(edic)-16(t)-32(ing post)17(oper)-32.9(a)15(t)-32(i)-16(ve sur)-32(v)-16(i)-16(v)-15(al. )]TJ /T1_3 1 Tf (J Surg Oncol)Tj /T1_2 1 Tf (. 2013 )Tj -0.012 Tw T* [(Ap)25(r;107\(5\):486\22692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/jso.23283)Tj 0 0 0 1 k /GS1 gs -0.012 Tw [( Epub 2012 N)-13.9(ov 5. PMID: )]TJ 0 Tw T* (23129564.)Tj 0.087 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Al)-16(amr)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC 2.963 0 Td [(Y, )0.6(Buchw)-12(ald)]TJ /Span<>> BDC ( )Tj EMC 5.189 0 Td [(P, )0.6(Dix)10(on)]TJ /Span<>> BDC ( )Tj EMC 3.623 0 Td [(L, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.099 0 Td [(al. )0.6(Sal)30(v)-15(a)-17(ge )0.5(sur)-31.9(ger)-24(y )0.5(in )0.6(p)32(a)15(t)-32(ients )]TJ 0.22 Tw -15.17 -1.25 Td [(wi)-24(t)-12.9(h r)-24(ecur)-23.9(r)-24(ent or r)-23.9(esidual squamous )0.5(cell car)-31.9(c)-24(inoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he anus. )]TJ /T1_3 1 Tf 0.346 Tw T* [(Eur J )0.5(Surg Oncol.)]TJ /T1_2 1 Tf [( 2016 N)-14(ov;42\(11\):1687\2261692. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ejso.2016.05.006)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2016 Ma)15(y 25. PMID: 27241923.)]TJ 0.209 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)29(or)-32(ob)12(yov)]TJ /Span<>> BDC ( )Tj EMC [(G.I., S)-16(hel)35.1(ygin Y)35(u.A., Nechushk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(M.I., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(esul)56(ts )]TJ 0.033 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(sur)-32(gical tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-23.9(t)-13(h r)-24(esidual and r)-23.9(ecur)-24(r)-24(ent tumor)-10(s )]TJ 0.228 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he anal canal. )]TJ /T1_3 1 Tf [(Surg)12(er)-43(y. The)]TJ /Span<>> BDC ( )Tj EMC [(jour)-13.9(nal named af)-46(ter N.I.)]TJ /Span<>> BDC ( )Tj EMC (Pirogov. )Tj /T1_2 1 Tf 0.023 Tw T* (2008\(8\):4\2269. \(in Russ.\).)Tj 0.013 Tc 0.481 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.848 0 Td [(Ha)-17.1(gemans)]TJ /Span<>> BDC ( )Tj EMC [(J)14.9(A)26.9(W, Bl)-31.1(inde)]TJ /Span<>> BDC ( )Tj EMC [(SE, Nuy)-16.1(t)-30.1(tens)]TJ /Span<>> BDC ( )Tj EMC [(JJ, e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sal)29.9(v)-15.1(a)-17(ge)13( )]TJ 0.46 Tw -1.848 -1.25 Td [(A)-13.5(b)0.5(d)-15.4(o)0.5(m)0.5(i)0.5(n)0.5(o)0.5(p)0.5(e)0.5(r)-36.4(i)0.5(n)0.5(e)0.5(a)0.5(l)0.5( R)13.5(e)0.5(s)0.5(e)0.5(c)-15.5(t)-31.5(i)0.6(o)0.5(n)0.5( f)0.5(o)0.5(r)0.6( S)0.5(q)0.5(u)0.5(a)0.5(m)0.6(o)0.5(u)0.5(s)0.5( C)0.5(e)0.5(l)0.6(l)0.5( A)0.5(n)0.5(a)0.6(l)0.5( C)0.5(a)0.5(n)0.5(c)0.5(e)0.5(r)0.6(:)13( )]TJ 0.003 Tc 0.349 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(30-Y)30.4(ear)0.5( S)-15.6(ingl)0.5(e-Ins)0.5(t)-31.6(i)-23.6(tut)-31.6(i)0.5(on E)35.4(x)0.5(per)-36.6(ien)0.5(ce. )]TJ /T1_3 1 Tf [(A)0.5(nn)0.5( Surg)0.5( Onco)0.5(l.)]TJ /T1_2 1 Tf [( 201)0.5(8)3( )]TJ 0 Tc 0.125 Tw T* [(Jul;25\(7\):1970\2261979. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1245/s10434-018-6483-9)Tj 0 0 0 1 k /GS1 gs 0.125 Tw ( Epub 2018 )Tj 0.023 Tw T* [(Ap)25(r 24. PMID: 29691737; PMCID: PMC5976705.)]TJ 0.01 Tc 0.371 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td [(Guer)-23.9(r)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(GR, K)25.1(ong)]TJ /Span<>> BDC ( )Tj EMC [(JC, Ber)-14.9(nar)-23.9(di)]TJ /Span<>> BDC ( )Tj EMC [(MP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sal)30.1(v)-15(a)-16.9(ge Sur)-31.9(ger)-23.9(y)10( )]TJ 0.003 Tc 0.35 Tw -1.836 -1.25 Td [(for )0.5(L)35.1(o)-16(cor)-24(egional )0.5(F)20.1(ail)35(ur)-23.9(e )0.6(in )0.5(Anal )0.6(Squamous )0.5(Cell )0.6(Car)-32(c)-23.9(inoma. )]TJ /T1_3 1 Tf -0.003 Tw 26.461 0 Td [(Dis)3.1( )]TJ 0.025 Tc 0.896 Tw -26.461 -1.25 Td [(Colon R)21.1(ectum)]TJ /T1_2 1 Tf [(. 2018 F)10.1(eb;61\(2\):179\226186. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.025 Tw (10.1097/)Tj 0 Tc 0 Tw T* (DCR.0000000000001010)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 29337772.)Tj 0.111 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(osen)]TJ /Span<>> BDC ( )Tj EMC [(R, Q)-16(uezad)42(a-Dia)-24(z)]TJ /Span<>> BDC ( )Tj EMC (FF, G\366nen)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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\215)10.2(\020)1.7(\026)4(\027)-0.9(\030)18(\f)9.6(\022)]TJ /Span<>> BDC ( )Tj EMC [(\207)27.6(.)3.7(\207)27.7(.)7.8(, )]TJ 0 Tw T* [(\216)101.4(\031)4.9(\032\030)1.9(\027)-0.9(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2(.)43.7(\205)-2.1(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.057 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.3(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.9(ek)-17.5(s)7.8(a)-0.8(n)3.8(t)-29.1(s)4.9(e)-4(v)33.6(, )]TJ 1.302 Tw T* [(M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.6(r)-14.6(n)6.2(y)5.7(k)5.3(h)-6(, E)19.6(l)4.8(e)-2.6(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(R)7.2(om)4.3(a)-0.8(n)1.9(ov)10.8(a)-14(, )]TJ 1.163 Tw T* [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)33.6(, A)3.7(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.4(e)-4(v)7.6(o)-1.1(l)-28.6(s)9.1(k)-18.5(i)7.9(k)5.3(h)-6(, )]TJ 0.653 Tw T* [(V)-5.5(i)3(o)-1.1(l)4.9(e)-4.5(t)-28(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-1(e)-6.1(e)-2.6(n)7.5(k)12.9(o)-3.7(, S)15.8(u)2.8(l)9.7(t)2.3(a)-0.8(n)4.8(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-1.6(r)2.4(e)-3.5(g)-2.5(o)1.3(r)2.4(o)-7.8(d)1.4(i)3(e)-4(v)10.9(a)-14(, )]TJ 0.001 Tc -0.001 Tw T* [(Z)6.6(am)5.4(an)]TJ /Span<>> BDC 2.62 0 Td ( )Tj EMC [(Z)5(.)]TJ /Span<>> BDC 0.969 0 Td ( )Tj EMC [(M)6.2(am)5.8(me)-7.7(d)4.3(l)5.3(i)-2(,)1( S)6.6(e)-0.7(r)3.3(g)-1.5(e)-1.4(y)]TJ /Span<>> BDC 7.248 0 Td ( )Tj EMC [(S)3.1(.)]TJ /Span<>> BDC 0.99 0 Td ( )Tj EMC [(Go)2.3(r)2.5(de)-5.2(e)-3(v)]TJ /T1_1 1 Tf 0 Tc 1.275 Tw -11.826 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.5(n)-4.6(d p)-3.8(r)-5.9(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e m)1.8(a)-8.4(t)-15.2(e)]TJ 0 Tw 21.758 0 Td (-)Tj -0.005 Tc 0.005 Tw -21.758 -1.218 Td [(r)-53(ia)-6.5(l)-27.5(:)]TJ /T1_3 1 Tf 0 Tc 0.703 Tw 1.679 0 Td [( D)-6.1(e)-2.6(n)6.2(i)11.1(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.9(ek)-17.5(s)7.8(a)-0.8(n)3.8(t)-29.1(s)4.9(e)-4(v)33.6(, )0.5(M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC 16.655 0 Td [(C)3.2(h)1.9(e)-1.7(r)-14.6(n)6.2(y)5.7(k)5.3(h)-6(, )]TJ 1.357 Tw -18.334 -1.218 Td [(E)19.6(l)4.8(e)-2.6(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(R)7.2(om)4.3(a)-0.8(n)1.9(o)-0.6(v)10.8(a)-14(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)33.6(, )]TJ 0.972 Tw T* [(A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC 4.146 0 Td [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.3(e)-4(v)7.6(o)-1(l)-28.6(s)9.1(k)-18.5(i)7.9(k)5.3(h)-6(, V)-5.5(i)3(o)-1(l)4.8(e)-4.4(t)-28.1(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-0.9(e)-6.2(e)-2.6(n)7.5(k)12.9(o)-3.7(, )]TJ 0.714 Tw -4.146 -1.218 Td [(S)15.8(u)2.8(l)9.7(t)2.3(a)-0.8(n)4.8(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-1.7(r)2.4(e)-3.5(g)-2.5(o)1.3(r)2.4(o)-7.8(d)1.4(i)3(e)-3.9(v)10.8(a)-14(, Z)5.6(a)-0.8(m)4.4(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(Z)4(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.2(a)-0.8(m)4.7(m)-1.1(e)-8.7(d)3.4(l)4.3(i)-3.1(, )]TJ -0.002 Tc 0.002 Tw T* [(S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 0.99 0 Td ( )Tj EMC [(G)-3.4(o)-0.7(r)-0.6(d)-2.9(e)-8.2(e)-6(v)]TJ /T1_1 1 Tf -0.007 Tc 1.182 Tw -3.557 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.175 Tw 10.263 0 Td [( D)-6.1(e)-2.6(n)6.2(i)11.1(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.9(ek)-17.5(s)7.8(a)-0.8(n)3.8(t)-29.1(s)4.9(e)-4(v)33.6(, )]TJ 1.302 Tw -10.263 -1.218 Td [(M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.6(r)-14.6(n)6.2(y)5.7(k)5.3(h)-6(, E)19.6(l)4.8(e)-2.6(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(R)7.2(om)4.3(a)-0.8(n)1.9(ov)10.8(a)-14(, )]TJ 1.163 Tw T* [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)33.6(, A)3.7(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.4(e)-4(v)7.6(o)-1.1(l)-28.6(s)9.1(k)-18.5(i)7.9(k)5.3(h)-6(, )]TJ 0.653 Tw 0 -1.218 TD [(V)-5.5(i)3(o)-1.1(l)4.9(e)-4.4(t)-28.1(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-1(e)-6.1(e)-2.6(n)7.5(k)12.9(o)-3.7(, S)15.8(u)2.8(l)9.7(t)2.3(a)-0.8(n)4.8(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-1.6(r)2.4(e)-3.5(g)-2.5(o)1.3(r)2.4(o)-7.8(d)1.4(i)3(e)-4(v)10.9(a)-14(, )]TJ 0.001 Tc -0.001 Tw 0 -1.218 TD [(Z)6.6(am)5.4(an)]TJ /Span<>> BDC 2.62 0 Td ( )Tj EMC [(Z)5(.)]TJ /Span<>> BDC 0.969 0 Td ( )Tj EMC [(M)6.2(am)5.8(me)-7.7(d)4.3(l)5.3(i)-2(,)1( S)6.6(e)-0.7(r)3.3(g)-1.5(e)-1.4(y)]TJ /Span<>> BDC 7.248 0 Td ( )Tj EMC [(S)3.1(.)]TJ /Span<>> BDC 0.99 0 Td ( )Tj EMC [(Go)2.3(r)2.5(de)-5.2(e)-3(v)]TJ /T1_1 1 Tf 0 Tc 0.979 Tw -11.826 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.2(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.2(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_3 1 Tf [( D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.7(n)3.8(t)-29.1(s)4.9(e)-4(v)33.6(, )]TJ 1.302 Tw 0 -1.218 TD [(M)5.2(ar)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.6(r)-14.6(n)6.2(y)5.7(k)5.3(h)-6(, E)19.6(l)4.8(e)-2.6(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(R)7.2(om)4.3(a)-0.8(n)1.9(ov)10.8(a)-14(, )]TJ 1.163 Tw T* [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)33.6(, A)3.7(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(N)2.4(e)-4(v)7.6(o)-1.1(l)-28.6(s)9.1(k)-18.5(i)7.9(k)5.3(h)-6(, )]TJ 0.653 Tw 0 -1.218 TD [(V)-5.5(i)3(o)-1.1(l)4.9(e)-4.4(t)-28.1(t)2.3(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)8.6(v)7.1(d)-1(e)-6.1(e)-2.6(n)7.5(k)12.9(o)-3.7(, S)15.8(u)2.8(l)9.7(t)2.3(a)-0.8(n)4.8(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)23.9(e)-1.6(r)2.4(e)-3.5(g)-2.5(o)1.3(r)2.4(o)-7.8(d)1.4(i)3(e)-3.9(v)10.8(a)-14(, )]TJ 0.001 Tc -0.001 Tw 0 -1.218 TD [(Z)6.6(am)5.4(an)]TJ /Span<>> BDC 2.62 0 Td ( )Tj EMC [(Z)5(.)]TJ /Span<>> BDC 0.969 0 Td ( )Tj EMC [(M)6.2(am)5.8(me)-7.7(d)4.3(l)5.3(i)-2(,)1( S)6.6(e)-0.7(r)3.3(g)-1.5(e)-1.5(y)]TJ /Span<>> BDC 7.248 0 Td ( )Tj EMC [(S)3.1(.)]TJ /Span<>> BDC 0.99 0 Td ( )Tj EMC [(Go)2.3(r)2.5(de)-5.2(e)-3(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 11.418 59.672 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.368 Tw 0 -1.218 TD [(\202\035\036\022\f\026\027\006\036\r )0.6(\212\036\027\017\f )0.5(\200\017\022\021\024\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 14.016 0 Td [(\227 )0.5(\026\f\023\017\030\026\027\021 )0.6(\205\206\207\211 )]TJ 0.387 Tw -14.016 -1.218 Td (\253\203\204\230\037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\207\035\024\b\017\027\026\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017, \204\024\f\022\r\026; ORCID 0000-0002-6478-0005)Tj 0.254 Tw T* (\232\036\030\027\t\b \204\026\030\017\027\026 \200\026\f\017\035\034\036\ \r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\n\036\f\021\017\021\036\035\034 )Tj 0.449 Tw T* (\007\017\030\036\022\021\024\030\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\024\035\024\020\017\004\036\f\022\017\n \n\036\021\024\007\ \026\n \035\036\004\036\027\017\016 )Tj -0.051 Tw T* (\203\230\230 \025\210, \026\r\036\007\031\033\013\026\016 \024\021\007\036\ \035\036\027\017\036\n \030\026\007\017\024\021\036\030\026\023\017\017,\ \205\206\207\211 )Tj 0.387 Tw 0 -1.218 TD (\253\203\204\230\037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\207\035\024\b\017\027\026\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017, \204\024\f\022\r\026; ORCID 0000-0003-4944-4035)Tj 0.473 Tw T* (\217\024\n\026\027\024\r\026 \213\035\036\027\026 \202\035\036\022\f\026\ \027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 0.048 Tw T* (\030\026\007\017\024\021\036\030\026\023\036\r\021, \f.\027.\f. \024\021\ \007\036\035\036\027\017\016 \030\026\007\017\024\021\036\030\026\023\017\ \017, \205\206\207\211 )Tj 0.387 Tw T* (\253\203\204\230\037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\207\035\024\b\017\027\026\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017, \204\024\f\022\r\026)Tj 0.648 Tw 0 -1.218 TD (\217\t\002\026\022\024\r \213\r\020\036\027\017\005 \206\036\027\027\026\ \007\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024)Tj 0 Tw (-)Tj 0.896 Tw 0 -1.218 TD (\235\036\f\f\024\030 \217\202\203, \030\031\022\024\r\024\007\017\021\036\ \035\034 \024\021\007\036\035\026 \024\027\022\024\023\030\024\022)Tj 0 Tw (-)Tj 0.765 Tw 0 -1.218 TD (\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\230\037 \022\024\ \035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\017 \ )Tj 0.508 Tw 0 -1.218 TD (\202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ , \204\024\f\022\r\026; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0002-3919-9067)Tj 0.612 Tw 0 -1.218 TD [(\203\036\r\024\035\034\f\022\017\b )0.6(\202\035\036\022\f\036\005 )0.5(\202\035\036\022\f\036\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 15.529 0 Td [(\227 )0.5(\007.\n.\027., )0.6(\026)]TJ 0 Tw (-)Tj 0.479 Tw -15.529 -1.218 Td [(\n\036\f\021\017\021\036\035\034 )0.6(\007\017\030\036\022\021\024\030\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 11.558 0 Td [(\035\036\004\036\002\027\024\005 )0.6(\030\026\002\024\021\036 )0.5(\204\217\203\037 )]TJ 0.372 Tw -11.558 -1.218 Td (\017\n. \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035\026 \205\206\207\211 \253\203\204\230\037 \ \030\026\007\017\024)Tj 0 Tw (-)Tj 1.1 Tw 0 -1.218 TD (\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\ \017, \210\002\027\017\027\f\022; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0001-5961-2958)Tj 0.06 Tw 0 -1.218 TD (\202\r\007\036\036\027\022\024 \200\017\024\035\036\021\021\026 \202\027\ \007\030\036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020 \024\002\013\036)Tj 0 Tw (-)Tj 0.125 Tw T* (\022\035\017\027\017\004\036\f\022\024\020\024 \023\036\030\f\024\027\026\ \035\026 \204\217\203\037 \017\n\036\027\017 \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\037\t\002\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.049 Tw T* (\235\017\035\017\026\035 \205\206\207\211 \253\203\204\230\037 \030\026\007\ \017\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\ \f\f\017\017, )Tj 0 Tw T* (\210\002\027\017\027\f\022; ORCID 0000-0002-2678-016X)Tj 0.222 Tw T* (\215\036\030\036\020\024\030\024\007\017\036\r\026 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\030\036\027\021\020\036\027\024\035\024\020 \203\230\ \230 \022\035\017)Tj 0 Tw (-)Tj 0.409 Tw T* (\027\017\004\036\f\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\005 \030\026\ \007\017\024\035\024\020\017\017 \205\206\207\211 )Tj 0.387 Tw T* (\253\203\204\230\037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\207\035\024\b\017\027\026\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0002-2014-586X)Tj 0.098 Tw T* (\204\026\n\036\007\035\017 \003\026\n\026\027 \003\026\031\030\024\r\017\ \004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031\033\013\017\005 \024\027)Tj 0 Tw (-)Tj 0.443 Tw T* (\022\024\035\024\020\017\004\036\f\022\017\n \024\021\007\036\035\036\027\ \017\036\n \b\017\030\031\030\020\017\004\036\f\022\017\b \n\036\021\024\ \007\024\r )Tj 0.079 Tw T* (\035\036\004\036\027\017\016 \223 3 \(\022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017\), \205\206\207\211 \253\203\204\230\037 \024\027\ \022\024)Tj 0 Tw (-)Tj 0.041 Tw T* (\035\024\020\017\017 \017\n. \203.\203.)Tj /Span<>> BDC ( )Tj EMC (\207\035\024\b\017\027\026\273 \204\017\027\007\030\026\r\026 \217\024\f\ \f\017\017, \204\024\f\022\r\026; )Tj 0 Tw T* (ORCID 0000-0002-9289-1247)Tj -0.066 Tw T* [(\206\024\030\007\036\036\r \222\036\030\020\036\005 )0.5(\222\036\030\020\036\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 10.833 0 Td [(\227 \007.\n.\027., )0.5(\r\036\007\031\013\017\005 )0.5(\027\026\031\004\027\t\005 )]TJ 0.417 Tw -10.833 -1.218 Td [(\f\024\021\030\031\007\027\017\022 )0.6(\024\027\022\024\035\024\020\017\004\036\f\022\024\020\024 )0.5(\024\021\007\036\035\036\027\017\016 )0.6(\b\017\030\031\030\020\017\004\036)]TJ 0 Tw (-)Tj 0.09 Tw T* (\f\022\017\b \n\036\021\024\007\024\r \035\036\004\036\027\017\016 \223 \ 3 \(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\), \205\ \206\207\211 )Tj 0.387 Tw T* (\253\203\204\230\037 \024\027\022\024\035\024\020\017\017 \017\n. \203.\203\ .)Tj /Span<>> BDC ( )Tj EMC (\207\035\024\b\017\027\026\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017, \204\024\f\022\r\026; ORCID 0000-0002-9303-8379)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Denis V. Alek)-9.9(santsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6478-0005)Tj 0 -1.218 TD [(Mar)-37(ina V. Cher)-14.9(nykh)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4944-4035)Tj 0 -1.218 TD [(Elena A. R)11.1(omanov)-15(a)]TJ T* [(Ev)-21(geny G. R)-19.9(ybakov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj T* [(Alek)-10(se)-10.9(y A. Nevolsk)-15.9(ikh)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5961-2958)Tj 0 -1.218 TD [(V)-15(iole)-12(t)-30(t)15.1(a A. A)15(v)12(deenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2678-016X)Tj 0 -1.218 TD [(Sul)56(t)15(ana)15(t S. P)30.1(er)-24(egor)-32(odiev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2014-586X)Tj 0 -1.218 TD [(Z)10(aman Z. Mammedl)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9289-1247)Tj 0 -1.218 TD [(Ser)-32(ge)-11(y S. Gor)-23.9(deev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-9303-8379)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.115 56.0378 Tm (26)Tj ET endstream endobj 14 0 obj <> endobj 15 0 obj <> endobj 16 0 obj <> endobj 17 0 obj <> endobj 18 0 obj <> endobj 1660 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1661 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1662 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1663 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1664 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1673 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\205\n\005\002\005\013\n\225\004\016\r)10(\025\004 \020\004\225\004\t\n\004 \224\017\n\004\t\026)11(\025\b \016\022\005\004\n\202\n\b\025\024 )]TJ 0 -1 TD [(\224\020\025\016\r)10(\025\r)-9.9(\020\004\026)11(\025\225\t\025\013)10(\025 \005\017\r\017 \017\t\017\020\200\t\025\013)10(\025 \r\017\t\017\020\017)]TJ 41.019 1 Td [(Sur)31(gical tr)31(eatment for patients with per)20.1(sistent and )]TJ 3.771 -1 Td [(r)31(ecurr)31.1(ent s)11(quamous cell anal car)31.1(cinoma)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.477 Tw 10 0 0 10 42.5197 724.8299 Tm (\222\030\036\007\017 12 \023\024\r\021\024\030\027\t\b \030\036\006\017\007\ \017\r\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\f\021\017 \021\026\026 )Tj 0.462 Tw 0 -1.218 TD (5)Tj /Span<>> BDC ( )Tj EMC (\(41,7%\) \027\036 \017\n\036\035\017 \024\023\030\036\007\036\035\201\027\ \027\024\005 \035\024\022\026\035\017\026\006\017\017, )Tj 0.144 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC 0.876 0 Td [(\(25,0%\) )0.5(\035\024\022\026\035\017\024\r\026\035\017\f\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 11.413 0 Td [(\024\002\035\026\f\021\017 )0.6(\026\023\017\030\026\021\036\035\034\027\024\005 )]TJ 0.235 Tw -12.29 -1.218 Td (\n\t\001\006\t, 2)Tj /Span<>> BDC ( )Tj EMC (\(16,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \f\021\036\027\022\036 \r\035\026\020\026\035\017\013\ \026 )Tj 0.229 Tw T* (\(\r \024\002\024\017\b \f\035\031\004\026\016\b \024\023\031\b\024\035\034\ \017\f\b\024\007\027\024 \035\024\022\026\035\017\024\r\026\035\026\f\034\ )Tj 0.541 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\036\007\027\036\005 \023\024\035\031\024\022\030\031\032\027\ \024\f\021\017 )0.5(\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, )]TJ 0.059 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036)Tj /Span<>> BDC ( )Tj EMC (\227 \002\t\035\026 \r\t\023\024\035\027\036\027\026 \030\036\036\022\006\ \017\016 \r\035\026\020\026\035\017\013\026\), )Tj -0.021 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(8,3%\) \f\035\031\004\026\036)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\036\f\022\026\030\026\035\034\027\024 \(\017\f\b\024\007\027\ \024 \002\t\035\026 \r\t)Tj 0 Tw (-)Tj 0.21 Tw T* (\023\024\035\027\036\027\026 R1 \030\036\036\022\006\017\016, \024\023\031\ \b\024\035\034 \002\036 \004\201\021\022\024\005 \020\030\026\027\017\006\ \t )Tj 0.121 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\022\024\f\021\027\017\006\036\005 \022\030\036\f\021\006\026\ \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \026\002\f\006\036\f\f\026\ )Tj 0.201 Tw T* (\023\030\036\f\026\022\030\026\035\034\027\024, \023\024\f\035\036\007\027\ \017\005 \r\f\022\030\t\021 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \n\024\002\017)Tj 0 Tw (-)Tj 0.116 Tw T* (\035\017\026\006\017\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\r 1)Tj /Span<>> BDC ( )Tj EMC (\(8,3%\) \f\035\031\004\026\036)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\036\f\026\022\030\026\035\034\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 )Tj 0.021 Tw 0 -1.218 TD (\002\024\022\024\r\024\005 \f\021\036\027\022\036 \021\026\026. \212\r\026\ \(3,2%\) \023\026\006\017\036\027\021\026 \023\036\030\036\027\036\f\035\ \017 )Tj 0.244 Tw 0 -1.218 TD (\023\024\r\021\024\030\027\031\033 \024\023\036\030\026\006\017\033)Tj /Span<>> BDC ( )Tj EMC (\227 \031\007\026\035\036\027\017\036 \024\023\031\b\024\035\017 \026\007\ \027\036\005 )Tj 0.237 Tw 0 -1.218 TD (\f\021\036\027\022\017 \r\035\026\020\026\035\017\013\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\033 \212\033\022\036\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017)Tj 0 Tw (-)Tj 0.145 Tw T* (\030\024\r\026\027\027\024\n \030\036\006\017\007\017\r\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\b\024\r\024\n \035\017\n\235\026\021\017\004\036\f\022\024\n \031\ \035\036 )Tj 0.239 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (2 \(3,2%\) \r\t\023\024\035\027\036\027\026 \023\024\r\021\024\030\027\026\ \016 \035\031\004\036\r\026\016 \021\036\030\026\023\017\016, )Tj 0.097 Tw T* (7)Tj /Span<>> BDC ( )Tj EMC (\(11,2%\) \023\024\035\031\004\017\035\017 \b\017\n\017\024\021\036\030\026\ \023\017\033, 6)Tj /Span<>> BDC ( )Tj EMC (\(9,6%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\035)Tj 0 Tw (-)Tj T* (\035\017\026\021\017\r\027\024\036 \035\036\004\036\027\017\036.)Tj 0.131 Tw T* [(\211 )0.5(10)]TJ /Span<>> BDC ( )Tj EMC 2.221 0 Td [(\(16,4%\) )0.5(\023\026\006\017\036\027\021\024\r )0.6(\026\030\036\020\017\f\021\030\017\030\024\r\026\027\t )0.6(\024\021\007\026\035\036\027)]TJ 0 Tw (-)Tj 0.053 Tw -2.221 -1.218 Td (\027\t\036 \n\036\021\026\f\021\026\t \(\023\036\004\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\) \023\026\006\017\036\027\021\024\r, \035\036\020)Tj 0 Tw (-)Tj 0.148 Tw T* (\022\017\036)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(6,6%\), \026\002\030\033\001\017\027\027\t\036 \035/\031)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(3,2%\), )Tj 0 Tw T* (\022\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\).)Tj 0.145 Tw T* (\204\036\007\017\026\027\026 \210\200 \023\026\006\017\036\027\021\024\r\ \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\t\n \030\036\006\017\007\017\r\024\n \f\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\021\026\r\017\035\026 23,90 [95% \212\230: 23,70\22624,10] \n\036\f\016\ \006\036\r, \f)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.061 Tw T* (\007\026\035\036\027\027\t\n\017 \n\036\021\026\f\021\026\026\n\017 \210\ \200 \f\024\f\021\026\r\017\035\026 13,8 [95% \212\230: )Tj 0 Tw T* (4,10\22629,70] \n\036\f\016\006\036\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 371.6678 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.02 Tw 10 0 0 10 42.5197 347.3118 Tm (\207\215\233 \024\f\021\026\036\021\f\016 \024\f\027\024\r\027\t\n \r\026\ \030\017\026\027\021\024\n \035\036\004\036\027\017\016 \007\035\016 \023\ \026\006\017)Tj 0 Tw (-)Tj -0.053 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\t\n \024\021\r\036\021\024\n \017\035\017 \030\036\ \006\017\007\017\r\024\n \030\026\022\026 \026\027\026\035\034)Tj 0 Tw (-)Tj 0.149 Tw T* [(\027\024\020\024 )0.5(\022\026\027\026\035\026. )0.6(\230-\026 )0.5(\024\021\027\024\f\017\021\036\035\034\027\024\005 )0.5(\030\036\007\022\024\f\021\017 )0.5(\007\026\027\027\024\005 )]TJ 0.297 Tw T* (\027\024\024\035\024\020\017\017, \002\024\035\034\001\017\027\f\021\r\024\ \024\023\031\002\035\017\022\024\r\026\027\027\t\b \017\f\f\035\036\007\ \024)Tj 0 Tw (-)Tj 0.072 Tw T* (\r\026\027\017\005 \024\f\027\024\r\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\n \004\017\f\035\036 \023\026\006\017\036\ \027\021\024\r, \035\036)Tj 0 Tw (-)Tj 0.056 Tw T* (\004\017\r\001\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \007\035\017\021\036\035\034\027\024\020\024\ \023\036\030\017\024\007\026, \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\220\021\024\n\031 )Tj 0 Tw T* (\f\022\035\024\027\027\t \022)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\027\024\005 \f\021\036\023\036\027\017\ \023\030\036\007\r\016\021\024\f\021\017.)Tj 0.326 Tw 23.244 45.059 Td (\221\030\036\b\035\036\021\027\016\016 \024\002\013\026\016 \r\t\032\017\ \r\026\036\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\r\026\027\017\017, \030\026\r\027\026\016 63,2%, \016\r\035\016\036\021\ \f\016 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 )Tj 0.274 Tw T* [(\r\t\f\024\022\017\b \f\030\036\007\017 \024\023\031\002\035\017\022\024\ \r\026\027\027\t\b )0.5(\007\030\031\020\017\n\017 \026\r\021\024\030\026\n\017 )]TJ 0 Tw T* (\(23\22669%\) [8\22610].)Tj 0.07 Tw T* (\221\026\022\032\036 \f\021\024\017\021 \024\021\n\036\021\017\021\034, \ \004\021\024 \004\026\f\021\024\021\026 R0 \030\036\036\022\006\017\005\ \r)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.091 Tw T* (\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \002\t\035\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 90,3%, \004\021\024 \r\t\001\036, )Tj 0.004 Tw 0 -1.218 TD (\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\024\020\017\004\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\016\b, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \004\026\f\021\024\021\026 )Tj 0 Tw 0 -1.218 TD (R0-\024\023\036\030\026\006\017\005 \002\t\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 75,6\22680,9% [11\22613].)Tj 0.218 Tw T* [(\215\024\r\021\024\030\027\t\036 \030\036\006\017\007\017\r\t \023\024\f\ \035\036 )0.5(\207\215\233 \026\030\036\020\017\f\021\030\017\030\024\r\026\027\t )]TJ -0.019 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (16)Tj /Span<>> BDC ( )Tj EMC (\(26,2%\) \023\026\006\017\036\027\021\024\r, \004\021\024 \f\024\024\021\ \r\036\021\f\021\r\031\036\021 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj -0.041 Tw T* (\027\017\016\n \007\030\031\020\017\b \026\r\021\024\030\024\r, \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\021\024\030\t\b \220\021\024\021 \023\024\022\ \026\026)Tj 0 Tw (-)Tj T* (\021\036\035\034 \027\026\002\035\033\007\026\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 8\22648% [10\22612].)Tj 0.272 Tw T* (\200 \027\026\f\021\024\016\013\036\n \017\f\f\035\036\007\024\r\026\027\ \017\017 2 \023\026\006\017\036\027\021\026\n \023\024\r\021\024\030\027\ \024 )Tj 0.102 Tw T* (\002\t\035\026 \023\030\024\r\036\007\036\027\026 \214\221 \023\024\f\035\ \036 \207\215\233, \017)Tj /Span<>> BDC ( )Tj EMC (1 \023\026\006\017\036\027\021 \023\024\035\031\004\017\035 )Tj 0.134 Tw T* (\023\024\r\021\024\030\027\024\036 \024\002\035\031\004\036\027\017\036 \ \023\036\030\036\007 \207\215\233 \017-\026 \024\001\017\002\022\017 \023\ \035\026)Tj 0 Tw (-)Tj 0.049 Tw T* [(\027\017\030\024\r\026\027\017\016 )0.5(\214\221. \215\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n )0.5(\026\030\031\002\036\032\027\t\b )0.5(\026\r\021\024\030\024\r, \023\024\r)]TJ 0 Tw (-)Tj 0.126 Tw T* (\021\024\030\027\026\016 \214\221 \023\024\021\036\027\006\017\026\035\034\ \027\024 \n\024\032\036\021 \002\t\021\034 \017\035\036\004\017\r\026\033\ \013\036\005 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \n\036\f\021\027\t\b \030\036\006\017\ \007\017\r\024\r [8,9].)Tj 0.02 Tc 0.287 Tw T* [(\210\020\030\026\027\017\004\036\027\017\036\n \027\026\001\036\020\024 \ \017\f\f\035\036\007\024\r\026\027\017\016 \n\024\032\036\021 \002\t\021\ \034)20( )]TJ 0.616 Tw T* [(\027\036\024\007\027\024\030\024\007\027\t\005 \b\026\030\026\022\021\036\ \030 \023\026\006\017\036\027\021\024\r, \f\r\016\026\027\027\t\005)20( )]TJ 0.365 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\017\n \007\017\026\023\026\024\027\024\n \007\024\ \024\002\035\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.26 Tw T* (\001\036\027\017\036\n \030\036\032\017\n\026 \216\214\221, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\005 \n\036\030\036, \031)Tj /Span<>> BDC ( )Tj EMC [(37,1%)20( )]TJ -0.02 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj 0 Tc 0.157 Tw T* (\233\021\024 \017\f\f\035\036\007\024\r\026\027\017\036 \024\020\030\026\ \027\017\004\036\027\024 \036\020\024 \030\036\021\030\024\f\023\036\022\ \021\017\r\027\t\n )Tj -0.006 Tw T* [(\b\026\030\026\022\021\036\030\024\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.724 0 Td [(\027\036\002\024\035\034\001\017\n )0.6(\022\024\035\017\004\036\f\021\r\024\n )0.5(\023\026\006\017\036\027\021\024\r, )0.6(\f\024)]TJ 0 Tw (-)Tj 0.151 Tw -5.724 -1.218 Td (\002\030\026\027\027\t\b \026)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\t\005 \023\036\030\017\024\007 \r\030\036\ \n\036\027\017. \215\026\006\017\036\027\021\t )Tj 0.265 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\017\f\021\017\030\031\033\013\017\n \017\035\017 \030\036\ \006\017\007\017\r\027\t\n \026\002\024\035\036\r\026\027\017\036\n )Tj 0.051 Tw T* (\017\n\036\033\021 \030\026\035\017\004\027\031\033 \002\017\024\035\024\ \020\017\033 \024\023\031\b\024\035\017, \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\007\017\027\036\027\017\036 )Tj 0.171 Tw T* (\220\021\017\b \f\035\031\004\026\036\r \n\024\032\036\021 \023\024\r\035\ \017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \b\017\030\031\030)Tj 0 Tw (-)Tj 0.209 Tw T* [(\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016. )0.5(\215\030\036\017\n\031\013\036\f\021\r\024\n \007\026\027\027\024\005 \030\ \026\002\024\021\t )]TJ 0.049 Tw T* (\016\r\035\016\036\021\f\016 \021\024, \004\021\024 \220\021\024 \023\036\ \030\r\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.181 Tw T* [(\002\t\035 \023\030\024\r\036\007\036\027 )0.5(\026\027\026\035\017 )0.5(\030\024\035\017 \027\026\030\031\001\036\027\017\016 )0.5(\030\036\032\017\n\026 \216\214\221 )]TJ 0.178 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\t )0.5(\035\036\004\036\027\017\016 )0.5(\030\036\006\017\007\017\r\027\024\005 \024\023\031\b\024\035\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.522 Tw T* (\032\036 \026\027\026\035\017 \021\024\023\024\n\036\021\030\017\004\036\ \f\022\024\020\024 \022\026\030\021\017\030\024\r\026\027\017\016 \216\214\ \221. )Tj 0.742 Tw T* (\203\036\007\024\f\021\026\021\022\024\n \016\r\035\016\036\021\f\016 \024\ \021\f\031\021\f\021\r\017\036 \023\024\035\027\024\006\036\027\027\024\020\ \024 )Tj 0.129 Tw T* [(\026\027\026\035\017\026 )0.5(\021\024\023\024\n\036\021\030\017\004\036\f\022\017\b )0.5(\022\026\030\021, \021.\022. )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \030\036\021\030\024)Tj 0 Tw (-)Tj 0.043 Tw T* (\f\023\036\022\021\017\r\027\024\020\024 \026\027\026\035\017\026 \007\026\ \027\027\t\036 \002\t\035\017 \023\024\021\036\030\016\027\t \031)Tj /Span<>> BDC ( )Tj EMC (57,3% )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj ET q 42.52 253.502 143.265 -141.731 re W n q /GS0 gs 143.2647722 0 0 141.8581843 42.5196835 111.644196 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.267 Tw /Span<>> BDC 10 0 0 10 185.7845 111.7701 Tm ( )Tj EMC ET q 192.034 253.502 158.407 -141.732 re W n q 158.406662 0 0 141.8185674 192.0344758 111.683802 cm /Im1 Do Q Q BT /T1_3 1 Tf /Span<>> BDC 10 0 0 10 350.4411 111.7701 Tm ( )Tj EMC ET q 356.691 253.502 138.267 -141.732 re W n q 138.2675059 0 0 141.8701395 356.6911296 111.6322524 cm /Im2 Do Q Q BT /T1_3 1 Tf -0.031 Tw 9 0 0 9 42.5197 100.9701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( \004\032\031\b\025\031\024\023\022\007\027\024\n\022\027 \203\020\n\023\ \031\032\013 )0.5(\031\240\212\027\235 \021\013\255\022\021\020\027\026\031\024\023\022: )0.6(A)]TJ /Span<>> BDC ( )Tj EMC 26.782 0 Td (\227 \025\020\032\r\213\027\025\022\027 \032\027\255\022\026\020 \225\035\ ; B)Tj /Span<>> BDC ( )Tj EMC (\227 \032\027\n\023\031\021\020\b\022\025\020\f\017\025\013\235 \024\021\ \022\212, )Tj 0 Tw -26.782 -1.2 Td (C)Tj /Span<>> BDC ( )Tj EMC (\227 N-\024\023\020\023\r\024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( Prognostic factors for ov)13.2(erall sur)-41.9(viv)16(al: A)]TJ /Span<>> BDC ( )Tj EMC (\227 violation of)Tj /Span<>> BDC ( )Tj EMC (the CRT regimen; B)Tj /Span<>> BDC ( )Tj EMC [(\227 rectov)16(aginal f)-43(istula; C)]TJ /Span<>> BDC ( )Tj EMC (\227 N-status)Tj ET 1 0.68 0 0.12 k /GS0 gs 165.74 111.77 19.843 19.843 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 172.455 117.7039 Tm (A)Tj ET 1 0.68 0 0.12 k 328.819 111.77 19.843 19.843 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 335.5337 117.7039 Tm (B)Tj ET 1 0.68 0 0.12 k 476.22 111.77 19.843 19.843 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 483.4248 117.7039 Tm (C)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.7771 56.0378 Tm (25)Tj ET endstream endobj 1674 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,(+""   !1A2Sq "#$%&'()*3456789:BCDEFGHIJQRTUVWXYZabcdefghijrstuvwxyz ])!1AQ"aq#$2BR %&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz񸹺?*Ig(l-uk 6Xն$gi1 Ph3<~UMS:=բ(95[ +Ra;pZQku~Vٶѭzgd㋜XΒ]Rݲ;|+ZKvˠnSI<" """"" """""-tF- TL&TIR?\m#>(wJDDDD@DDDDD@DDDDD@DDDE\K&V.zX%|ժ/,5^756YEk;K6L"r%{K kf8ٴlc.ޘsZ:v-T3!6б֐ (T`2(vmuc+Y {85/6x|~oLYILd\Z8\p-N,ˋiTmMK}`mWܵ1eF-[-_͡ [xπbhpK|;|+@E]*g*eQIQjgCE a*EG2EDD[)* NۊDEn=,|ɾDդuK> d"j-$D@DDDDD@֪/,ߪ-,+sh`lXk[&뇄l`f͚6][vŐ.bFLMX`mr䚧blz~lkm-Bچ\xAa=G%e7)w$VID5ςbJdQkM!""ƢBYBz]YQYVMe&ԊIV @h1<)!IH9}$DE}}^+ ~)L'H]J4aQY^7Ot#"".:1QmTuZDseJ4l>""ƫ VҼm5Q8w MgDD@*Qn=,|ɾDդuK> d"j-$D@DDDDD@ת/Kamdvmv1\CrҠK*@u~TKc1̋RuH-a!Z h i /-ʬ]efܣ^G00X13…3vvvYe,f5ekcb&CmqH@El>#o|CraquK]h{HZ9ّ9RhfIm,n9cuUxM1CDsŕTc4=foF}5$٢"-c4=fo,fS!m7s|1ct2[RTDU[,Q#J"" v3Cnfms\*-R:+M_ 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m$-uƨNKdv.6 6ٰej潡wt:{]"I]2"" "ذr'ɛzьsˈ2(l6ocׁZHЌgڣjmKK{1Y۵n/iJga^Ju3%lںя @{hCCZ 8.ܸY[e,^084-U u99=gkb1̶[5lO].Ueʬ_aj icp`` 5w,r?'}OedZk,E2/shЪ*ܵV6'6YMghn:ӆa{mִc gd^-,[hDĉ(s7%uYoh2\gl6:ѡK*(!] "uwTNэvV/{[Y^pnu[At ]R""" """"" endstream endobj 1675 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,(K""   A!1QRS "#$%&'()*23456789:BCDEFGHIJTUVWXYZabcdefghijqrstuvwxyz!1"A2QaqR #$%&'()*3456789:BCDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?$81b(GՃkrS I)$|,{N42ҟ`<Þ㋛1aba8PƖnXb=!7 m珵<' sXkPαs;Mq˛Xyc AMK2rynIKyvg9cRicJݽ ݄'j Sqž,4pprϞ3*/;0On'  , Lume<,oÕEqvzC<$qsJ8*J2IyUOg{+,Nx7|㖜`v˜oh[чKeyof> w蠛:vͧxjV9Gh'rG)- 3{j~!m76w _3{j~!m7vw ӃhUcca⸿$ӊ[N ЪHر7,,56WqWnנO`ccIضdv\ڱp_3sÎ$d/ 'tJurճѪ ~ߠ"o3$69k Ra&;tXFM8|K0XgrQQI+= qŎ5 U{K3YNnz7N9fl6öV82:qQMn)j@8Ҫ ~ߠư~<,p7%)nRo3>f0'<ؒƥiiO8}ba8a`m6 26hbY^x($>-S;N8aXR&q#IVttS;vͷ=-l.usW賖תٲ9<,3KީZg1ڶMke۞ذd"qUVԣZa|\Ҕ,3)&ӎeikP)}alK2˳=BxyՇ8kMT|7՞Ӳ8ݗЩQQw7S]VKqZݭ9l;qp蔳IT4skzlFr$˄!*a]ew!ᎱF++DmAAuX c7h>iX#o z d"L6-0DaLc $d+( f'vje!1Oi|_$3lCd!G qmxx7acbb(JSYxWt| pv6)ZIoKtW<(x8„,<`œxWb&2pRjIEх (dm84d驤9pY3yd1Xض7rj,co9fx?V{o\`@qZNdc+I֒Y,DrdL.^m_=2f'vjeѪV-lTde,lL, r3ثlv ',u/` Uk["yYAqDfx?V{o\`@eɜ.L˅*l[%1i- k *L,+Z+8Z[vg-|2+*r˷k9levPk9ler2w;( 2w9Z[vtZ[vg-|`bg-|V]ne]01V]n+Yc.7sYc.7sȕP2c#Dbp3Ļgy|ɘ%?ͫ罔ҪJ[7 ࡉ8\u'8NPrÚBvݣ rض8OcĔ\bS^=ӗs C7 jum)F2n*M՞&>&Ӷccb牲m8j)(v1n[y"FWj2qA7yٽj2/{ׇBe_f=EMs? XnjKcYZqV@vc[3-X}r(ʭ<IKԃڌ@7yٽj2/{ׇBK jIl8X I\\EQojc9όlO7+Wyew0MF^eoz!ڌ@7yٽxm$y(8Jjq.rMF{(,]ھ{IǞ.&&Kfe% %Yڊk39NvѶbm0arQÎ͈UG@0֪&:ٱs),7ҺֹQ+m0!FX1MI{:Ŏ]e\h^p훚 p!#bbw괒K I*޶A|.m,( QRry1wY띨MV$,-󓓭'l=aP;ܡ 5emS&4Z%Sjr]x2')ba(PXyd;h_Lc#Gx,eS1$^*IĄY(I\E%,'Ĭ2\Ӵo7gfׁ($! ZRY3|]:9e#jc|IM19r+Gfpy9Alpb^&Y7ޛIJי|ԗ2剉,<<\ X2oeHI:qݹFlmfĂ< KXp)mI``- 3p'7mIÂI;o4%} xsib[2ń!ٙK aGJr'.d䩾.y^fbaCxx0#iroirsٴFRlE' IqmJe9JR[oVkXࣇ(,.y((($jIK iQ͚/ri4Rm)q2zfQ6KhͳƜL% i,PZUJYWb neVʰpqp 9X ;(v޻493g\`Fp¬EQRRyœCuy͙<6H,XlĎ"%Č)(BWn-ZCL3vl2Dxmޯqwסhs;if& a(1UDz:X]gG`X8 >,1 J1^IV6E6'͜Mx8x/f0p+ 0|k5BI>HEhgm8&ӷB+SuŒc-}Ngcs9`Mb XfŹIgvl" \yAf^=m龷69͘lq{ $ii;{9@Ъe/10a idmq,LhIbBXJ8 "XUZs+`'8Ep2Ąqڍ]ʣ&ꖭ' 36hY`ǿ XI B2n(źM&CjWtΘ x' 8Qxsd-Ik  n>&Ë>RY ILjJ-E:utC6~f;.նA[RSqrY=e0^fl8<ГxF4jSSIJ*$ӦQ L\{x|v൝Qoh{.ӶcbbC 79>$38'')J'U'nos.1Ž*[N \|8ʓ͆ڔ4oH7mt_46~VQ,~ԱO A'&&mia3i)=%,5U,mt(lݲ<b>ha/b()Hx9[̵SbsJV3V ڱ1g0N TrWӽ^:09M0x*,8Y8>w,! endstream endobj 1676 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,(!""  Q!1AR "#$%&'()*23456789:BCDEFGHIJSTUVWXYZabcdefghijqrstuvwxyz|!1AQ"aq2 #$%&'()*3456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz?0/l;I(+;tHnp Ig^W5K?kĖN8}^$p 0np Ig^W5K?kĖN8}^$p 0np Ig^W5K?I.Ob!fnbܔo82qqK^WaeVj6V8VDZrRVW[*޻vx[L&V$muO) fNa-uiek}&mfae5$x96vm9Exjm% 6%\X솇5;]Jp֭[,*VG$MyJ4UZ -%CWZ59276AݝWd޾*䝅b㼶oJιՕ^;um(*Z j9C=3MKBFhKS jTYt9OQhSOE3K $#i]+ .~1Eg8qht54ЄԬ2Bhƭ%6;rQbm'PWh+EbTJ^Fj%+50xTFi!dф#g*-1LCy)iYcB%0qahJ-ShHر|sI൱|sIVZ\bKMU5jz57 bJ)Y$O4դa!Y5h*J몕s *gbrƒ1#TF0PBִ2?alM3sZ\wfy&Ԫ0[*e~ʓt*@oY|dݗF?nՠ @)CErQ*! 0mM4ۭq&9sZ\wfy&.;óL[L֪0MR-zvVɬgc U:E]XlZevRvVpRr7Qi(x;H)U,4ye6J1wa*EFRo,[f ֪0݆Yz;m8GBeJ)cU 9&QFv66U8Q5D^,v6Z9+9IZ8%)R@ ei4JQQm)JSk3,K[\nvS+ HIUUUI&`GsY#ҼM+FK#[+W!\r{i,Vի)F:-qQ70F*7G,wS2=\ɝJ7DovNK]}覬l(vxdDDgv6c \*xE^e; {({'ʬ՚mq+IJxI_Yܴ~EmJ߇lgW%-5EI>stream endstream endobj 1678 0 obj <>stream endstream endobj 1677 0 obj <>stream endstream endobj 1668 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.016 Tw 10 0 0 10 70.8661 542.1599 Tm (\030\036\006\017\007\017\r\t \030\026\r\017\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (4/60 \(6,7%\) \023\026\006\017\036\027\021\024\r \(\031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.041 Tw 0 -1.218 TD [(\006\017\036\027\021\022\017 )0.6(\017\f\b\024\007\027\024 )0.5(\002\t\035\026 )0.5(\r\t\023\024\035\027\036\027\026 )0.6(2-\f\021\024\030\024\027\027\016\016 )0.5(\023\026\b\024)]TJ 0 Tw (-)Tj 0.159 Tw T* (\r\026\016 \035\017\n\235\024\007\017\f\f\036\022\006\017\016\), \023\024\ \r\021\024\030\027\t\036 \030\036\006\017\007\017\r\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\024)Tj 0 Tw (-)Tj 0.151 Tw T* (\r\t\b \035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\026\b)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\) \023\026\006\017\036\027\021\024\r. )Tj 0.292 Tw 23.244 3.653 Td (\222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(3,2%\) \023\026\006\017\036\027\021\024\r \002\t\035\017 )Tj 0.134 Tw T* (\017\024\035\017\030\024\r\026\027\027\t\036 \023\024\r\021\024\030\027\ \t\036 \030\036\006\017\007\017\r\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\b\024\r\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\031 )Tj 0.346 Tw T* (2)Tj /Span<>> BDC ( )Tj EMC (\(3,2%\))Tj /Span<>> BDC ( )Tj EMC (\227 \017\024\035\017\030\024\r\026\027\027\t\036 \023\024\r\021\024\030\ \027\t\036 \030\036\006\017\007\017\r\t )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\t\b \035\017\n\235\026\021\017\004\036\f\022\017\b \031\ \035\026\b.)Tj ET q 70.866 313.952 174.282 170.079 re W n q /GS0 gs 174.2822094 0 0 170.2012219 70.8661507 313.8302994 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.767 Tw /Span<>> BDC 10 0 0 10 245.1484 313.9528 Tm ( )Tj EMC ET q 275.148 313.952 165.067 170.079 re W n q 165.0672043 0 0 170.1056 275.1483765 313.9259246 cm /Im1 Do Q Q q 70.866 133.37 180.242 170.078 re W n q 180.2416043 0 0 170.1615142 70.8661495 133.2873413 cm /Im2 Do Q Q BT /T1_1 1 Tf /Span<>> BDC 10 0 0 10 251.1078 133.3701 Tm ( )Tj EMC ET q 276.107 133.37 187.515 170.078 re W n q 187.5148967 0 0 170.2279773 276.1077865 133.220914 cm /Im3 Do Q Q BT /T1_1 1 Tf 0.013 Tw 9 0 0 9 70.8662 122.5701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( A)Tj /Span<>> BDC ( )Tj EMC (\227 \031\240\212\020\t \021\013\255\022\021\020\027\026\031\024\023\017\ ; B)Tj /Span<>> BDC ( )Tj EMC (\227 \240\027\016\032\027\006\022\030\022\021\025\020\t \021\013\255\022\ \021\020\027\026\031\024\023\017 \240\027\016 \033\032\031\b\032\027\024\ \024\022\032\031\021\020\025\022\t, \205)Tj /Span<>> BDC ( )Tj EMC (\227 \032\020\016\f\022\007\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\212\027\235 )Tj 0.119 Tw 0 -1.2 TD [(\021\013\255\022\021\020\027\026\031\024\023\022 )0.6(\030\f\t )0.6(\032\027\006\022\030\022\021\031\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 14.005 0 Td [(\033\032\031\030\031\f\255\027\025\025\031\b\031 )0.6(\032\031\024\023\020, )0.6(D)]TJ /Span<>> BDC ( )Tj EMC 10.732 0 Td [(\227 )0.5(\032\020\016\f\022\007\022\t )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 6.29 0 Td [(\240\027\016\032\027\006\022\030\022\021\025\031\235 )0.5(\021\013\255\022\021\020\027\026\031\024\023\022 )0.5(\030\f\t )0.5(\032\027\006\022\030\022\021\031\021 )]TJ 0 Tw -31.028 -1.2 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\030\031\f\255\027\025\025\031\b\031 \032\031\024\023\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.029 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( A)Tj /Span<>> BDC ( )Tj EMC [(\227 ov)13(erall sur)-42(viv)16(al; B)]TJ /Span<>> BDC ( )Tj EMC [(\227 disease-free sur)-42(viv)16(al; C)]TJ /Span<>> BDC ( )Tj EMC [(\227 dif)-39.9(ferences in ov)13(erall sur)-42(viv)16(al for relapses and continued g)14(rowth, )]TJ 0 Tw T* (D)Tj /Span<>> BDC ( )Tj EMC [(\227 dif)-39.9(ferences in disease-free sur)-41.8(viv)16(al for relapses and continued g)14.3(rowth)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0 72.346 Td (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\030\025\031\203\020\n\023\031\032\025\013\235 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\025\031\b\031\203\020\n\023\031\032\025\013\235 \020\025\020\f\022\016\ \031\240\212\027\235 \021\013\255\022\021)0.5(\020\027\026\031\024\023\022 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\033\f\031\024\n\031\n\f\027\023\031\007\025\031\026 \032\020\n\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.8(l)-38.6(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( U)7.5(n)1.7(i)-2.9(v)6.3(a)-4.2(r)-38.9(i)1.5(a)-0.9(b)-3.4(le a)-5.1(n)-4.8(d m)1(u)-1.6(l)5.3(t)-29.1(i)-2.9(v)6.3(a)-4.2(r)-38.9(i)1.5(a)-0.9(b)-3.4(le s)6.7(u)1.6(r)-42.9(v)-32.5(i)-2.8(v)6.2(a)-4.4(l a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.7(s f)-13.4(o)-3(r o)-4.9(v)2.3(e)-6(r)3.3(a)-4.4(l)-3.9(l s)6.7(u)1.6(r)-42.9(v)-32.5(i)-2.9(v)6.3(a)-4.4(l o)4(f)]TJ /Span<>> BDC ( )Tj EMC 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B""vKF$(E#A/ Zp(0z5[ kֹk8$`$"M~aZW`:'lKGI̔E]UüӯM6%X7Y~1MϣQesCŮG\i(eZ *JeFK5/kv;z[Jٝ*6.0d/@pTEq9F7ifs[&Z+Lbf{\抍H H{z fckM|բ(hnQY g0s'I OS[Fڕ\eW .R\NR89NWM-B "" "" "" Ѫ"c4PfcSKKFpFZG1nFSF/q%hp/I$br.8ޅ/_ѦufZ[Igc\r5Z4j@^F$<Ѥs>C'$ΒD,wDDX6K9rL/I ,wDDX6K9rL/I ,wDDX:K9rH2<# z65^b2C-- ChMj<! tDEYDD@DD@DD@[ k׭rq޵~MkҪ"֞lss'6^6^xhoD8-> @3q5aˆ*cDS9HWgٴ=VekMVYDG;bs6m'@^1w~ NxX/9PPs+!ljD!ZabQDEi$4F,Xc/h*!oDDDDDDDDDDDDDDDDDDDDDDDDp$Z=N;%x9B9DEYDD@DD@DD@[ k׭rq޵~}MkӪ"c1[Y\3Zڮ~ZTHI[nv# 4B+=<(9 Ƀ`/-C[ RWxgAKH7]~/N&vjI@QNxX/9PTw~ #HRhh"> DDEäQݰxD2^@4XԎ,XeZ ,@DD@DDDDDDDDDDDDDDDDDDDDDDDbDH2<"A :F4YhA C^^iX"""Ǚzd9pL=28d<͐3!ȳ6@L"pK",9Ud"HrjI/"F,TVCLY gCg41b x3m-K%rZ\DqD܁\QB9`GU4tX98,chnw jt oZN7_ZDDDDDDDDDDDDDDDDDDԪ"IqP`pb^\ss=!0,f&*Pk sjU>PK@0n`[Qʙǂ-Zm~ l83k^z5@DD@DD@DD@DD@DD@DD@ժ"NxX/9PTw~ l83k^z5@DD@DD@DD@DD@DD@DD@֪"NxX/9PTw~ l83Wֽl83k^ת"Npq6V1j[QoRt]x"Q^Q s49j [Lxln#*6f8f+ssa~b(;[EMk@˘ f-pi0@p B^ҫN8ؼQNs حR/_s"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" -rq޵~}MkÃ98X~MkЪ"l:oR#]Ru0XRikի% PV/a6}5K?Mv]seA13'j灨a:$QjרL MV,\d Es--\YD-6ﲗ5#ctՍ@8lS[9 fJ"4})ׂR"4})x ?]]U=iN "oBྗ0ŵ@41aɸOP> Ufg=7l0GW3j_.h B_\__k~iq~)~S[|U.G!_eWk[PemmGɘ )^ KKmx/./e/j )^ KKJb1 PwR:n͵.='lyS{ý%궓ȿ}F 1.h9ǥ8û5(6T#TTsK ZM6ﲗ5|;a禆Ѩ_P6'j Cr I )^ KKmx/./e/j )^ KK< ,fM\Uj;>m(6nb"ѭoE>Zy^Uʹ--/fi/Xl]cAi k&:2`dXjvﲗ4_\__Ԟf0V:]tU,ô )^ KKmx/./e/j )^ KK򚗍^78V2Zx39ke$)V̪NƝlRə96{n mZZŮ}R0mAak9n@iE_\__k~iq~)~S\]YZ(ƀڷ Res\ޘa0$^mx/./e/i4})(mx/./e/jF6? o ֻN:LjK,0?J;iTE[.˕*)uap6ai6p1qj895=Ɂ3 -S1*נyQ8jd-k[Č6]Sgܙ\"4'rѪ"rٿwc}2 U|1԰< GRIoq8EtJ꨸n.e\n)ع(EIH"I9 /ܺC1~ (UVO{3 E@*EVk)m&".k "h7zUk0UMys|.6hҪ"J絎sYpi uȰPҨ v-!t+uc8(\RU M:5iq0$`\^? ҥTenļe-qm.3Crk!p"/QO_na jtbNJk̼CD_1)Sn1,( :qEA$:2 ɴ/$X4KI v?Z̾۶O3',GHo\jҩAV:ǴDezľ,u7p:tV6Ƙ:LFbxwVj8I{Kr2 EDDD]QHW4)r9C&^6:u"*Tn+D6y6n&I E+1\1Fs7h33yۘ PW裄0x=JtjJ31vxkDz9Ia `,"""".PTfM֗ 뀺W{qiQa9vVsEhɦC ٗ@Z4D@DD@E#rLfuz.n ujbpF6WJ{qңBCX){i$qr2HEKH@3,cX]aE C&v`NFbl\Uz**w va7fbVm ZsD@^ICKkA$ $,/WN´* UWifs)bC$<(0W)<`-\YtH'QӪ"Ԫ">R+pn :hu-1 8qH)ۀx2k) tb>4Sub^[ ]kG`kq/kaXU ּz(t1. vm6b%DQhxp3~ 14:VcFo1e>E)Wf!:JX<6.¸8j4dEp;c0TjxA3@F @`mWQ@YkQDD^N Aؚ0IKh$_R: gu, g5'l'4u&L]AM Cp iT4KtR8B"tKxޘ{kV(/ 'ѭT;[[ho[F1CNJ9k/%a6PPn1\4K }WYԥRbu"@9Mā+NQҠh45[V4ê:pl4@ZD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@DD@ժ" endstream endobj 1683 0 obj <>stream endstream endobj 1682 0 obj <>stream endstream endobj 1681 0 obj <>stream endstream endobj 1680 0 obj <>stream endstream endobj 1667 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\205\n\005\002\005\013\n\225\004\016\r)10(\025\004 \020\004\225\004\t\n\004 \224\017\n\004\t\026)11(\025\b \016\022\005\004\n\202\n\b\025\024 )]TJ 0 -1 TD [(\224\020\025\016\r)10(\025\r)-9.9(\020\004\026)11(\025\225\t\025\013)10(\025 \005\017\r\017 \017\t\017\020\200\t\025\013)10(\025 \r\017\t\017\020\017)]TJ 41.019 1 Td [(Sur)31(gical tr)31(eatment for patients with per)20.1(sistent and )]TJ 3.771 -1 Td [(r)31(ecurr)31.1(ent s)11(quamous cell anal car)31.1(cinoma)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.039 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\030\036\024\002\035\026\007\026\035\017 \n\036\024\030\036\022\021\ \026\035\034\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\), \023\026\b\024\r\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 Tw 0 -1.218 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\), \027\026\030\031\032\027\t\036 \023\024\007\r\007\024\001\027\ \t\036)Tj /Span<>> BDC ( )Tj EMC (\227 2)Tj /Span<>> BDC ( )Tj EMC (\(3,3%\).)Tj /T1_2 1 Tf 0.3 Tw 0 -2.436 TD (\032\b\004\f\t\213 \217\002\206\f\211\240\r\b\t\235 \220\f\t\b\t\201\r\217\ \220\t\216 \006\r\220\002\214\r\b\240\004\204\t\005 )Tj 0 Tw 0 -1.218 TD (\t\217\216\002\240\b\002\n\002 \f\r\201\r\b\t\235)Tj /T1_1 1 Tf -0.04 Tw T* (\215\030\017 \024\027\026\022\024\n\035\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\f\022\024\005 \007\024\022\031\n\036\027\021\026\ \006\017\036\005 \024\002)Tj 0 Tw (-)Tj -0.043 Tw 0 -1.218 TD (\027\026\030\031\032\036\027\024, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (23)Tj /Span<>> BDC ( )Tj EMC (\(37,7%\) \017)Tj /Span<>> BDC ( )Tj EMC (61 \023\026\006\017\036\027\021\024\r \r\t\016\r\035\036\027\t )Tj 0.091 Tw 0 -1.218 TD (\007\036\235\036\022\021\t \023\030\024\r\036\007\036\027\017\016 \216\214\ \221. \203\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\ \027\036\027)Tj 0 Tw (-)Tj 0.054 Tw T* [(\027\t\n )0.5(\027\026\030\031\001\036\027\017\036\n )0.6(\002\t\035\024 )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\017\035\017 )0.5(\027\036\023\030\026\r\017\035\034\027\024\036 )]TJ 0.099 Tw T* (\027\026\027\026\004\036\027\017\036 \f\024\004\036\021\026\027\027\024\ \005 \216\221 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \212\214\221, \022\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\021\024\030\024\036 \r\f\021\030\036\004\026\035\024\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\(14,8%\) \023\026\006\017\036\027\021\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\) )Tj 0.034 Tw T* (\024\021\n\036\004\036\027\t \023\036\030\036\030\t\r\t \r)Tj /Span<>> BDC ( )Tj EMC (\216\214\221 \017)Tj /Span<>> BDC ( )Tj EMC (\031 5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\) \r\t\016\r\035\036\027\t \027\026)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\031\001\036\027\017\016 \f\031\n\n\026\030\027\024\005 \007\024\t \ \214\221.)Tj 0.177 Tw 0 -1.218 TD [(\025\030\024\n\036 \021\024\020\024, )0.5(26/61 \(42,6%\) )0.5(\023\026\006\017\036\027\021\026\n )0.5(\031\007\026\035\024\f\034 )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.055 Tw 0 -1.218 TD [(\r\036\f\021\017 )0.5(\026\027\026\035\017 )0.6(\021\024\023\024\n\036\021\030\017\004\036\f\022\017\b )0.5(\022\026\030\021 )0.5(\030\026\007\017\022\026\035\034\027\024\005 )0.6(\035\031)]TJ 0 Tw (-)Tj 0.036 Tw T* (\004\036\r\024\005 \021\036\030\026\023\017\017 \023\036\030\r\017\004\027\ \024\005 \024\023\031\b\024\035\017. \222\030\036\007\017 \027\017\b \031\ )Tj /Span<>> BDC ( )Tj EMC (4/26 )Tj 0.2 Tw T* [(\(15,4%\) \027\036 )0.5(\017\f\023\024\035\034\024\r\026\027\026 )0.5(\204\217\221 \007\035\016 )0.5(\r\t\002\024\030\026 \024\002\255\036\n\024\r )]TJ 0.13 Tw T* [(\024\002\035\031\004\036\027\017\016, \024\002\255\036\n \023\036\030\r\017\ \004\027\024\005 \024\023\031\b\024\035\017 \(G)-12(T)-51.9(V\) \r\t\002\030\026\027 )]TJ 0.098 Tw T* (\027\036 \022\024\030\030\036\022\021\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (5/26 \(19,2%\), \031)Tj /Span<>> BDC ( )Tj EMC [(3/26 \(11,5%\) G)-12(T)-52(V \027\036 )]TJ 0.084 Tw T* [(\002\t\035 \024\022\024\027\021\031\030\036\027, \022\035\017\027\017\004\ \036\f\022\017\005 \024\002\255\036\n \024\002\035\031\004\036\027\017\016\ \(CT)-51.9(V\) )]TJ 0 Tw T* (\r\t\002\030\026\027 \027\036 \022\024\030\030\036\022\021\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (20/26 \(76,9%\) \f\035\031\004\026\036\r.)Tj /T1_2 1 Tf 0 -2.436 TD (\022\r\213\210\f\001\003\004\003\013 \216\t\006\210\006\n\t\201\r\217\220\ \002\n\002 \214\r\230\004\003\r\f\001\217\003\004)Tj /T1_1 1 Tf 0.267 Tw 0 -1.218 TD [(\215\024\022\026\026\027\017\016\n\017 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 6.965 0 Td [(\024\023\036\030\026\006\017\017 )0.6(\002\t\035 )0.5(\023\030\024\007\024\035\032\036\027\027\t\005 )0.6(\030\024\f\021 )]TJ 0.019 Tw -6.965 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.725 0 Td (27)Tj /Span<>> BDC ( )Tj EMC 1.251 0 Td [(\(44,3%\) )0.5(\f\035\031\004\026\016\b, )0.6(\035\017\002\024 )0.5(\027\036\023\024\035\027\t\005 )0.6(\024\021\r\036\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 17.357 0 Td (\216\214\221)Tj /Span<>> BDC ( )Tj EMC 1.776 0 Td (\227 )Tj 0.177 Tw -21.11 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (34)Tj /Span<>> BDC ( )Tj EMC [(\(55,7%\) \f\035\031\004\026\016\b. )0.5(\204\036\007\017\026\027\026 \r\030\036\n\036\027\017 \n\036\032\007\031\ \023\024)]TJ 0 Tw (-)Tj 0.048 Tw T* (\f\035\036\007\027\017\n \007\027\036\n \b\017\n\017\024\035\031\004\036\ \r\024\005 \021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\024\005 \024\023\036\030\026)Tj 0 Tw (-)Tj -0.015 Tw T* (\006\017\017 \f\024\f\021\026\r\017\035\026 8 \(IQR: 5,3\22615\) \n\036\f\ \016\006\036\r \007\035\016 \023\026\006\017\036\027\021\024\r )Tj 0.037 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\t\n \024\021\r\036\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (15 \(IQR: 11\22625,5\) \n\036\f\016\006\036\r \007\035\016 )Tj 0.256 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\030\036\006\017\007\017\r\024\n \026\002\024\035\036\r\026\027\017\016\ . )0.5(\217\026\007\017\022\026\035\034\027\026\016 )]TJ 0.194 Tw T* (\030\036\036\022\006\017\016 \(R0\) \002\t\035\026 \007\024\f\021\017\020\ \027\031\021\026 \031)Tj /Span<>> BDC ( )Tj EMC (55)Tj /Span<>> BDC ( )Tj EMC (\(90,2%\) \023\026\006\017)Tj 0 Tw (-)Tj 0.093 Tw T* [(\036\027\021\024\r, )0.5(\030\036\036\022\006\017\016 )0.5(\(R1\) \031)]TJ /Span<>> BDC ( )Tj EMC 9.853 0 Td (6)Tj /Span<>> BDC ( )Tj EMC [(\(9,8%\) \023\026\006\017\036\027\021\024\r. )0.5(\203\017 )0.5(\024\007\017\027 )]TJ -0.014 Tw -9.853 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \027\036 \031\n\036\030 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 30 \007\027\036\005 \023\024\f\035\036 \024\ \023\036\030\026)Tj 0 Tw (-)Tj 0.064 Tw T* (\006\017\017. \211)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \(57)Tj /Span<>> BDC ( )Tj EMC (\(93,4%\)\) \023\026\006\017\036\027\021\024\r \027\036 \002\t\035\024 )Tj 0.171 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017\035\017 \002\t\035\017 \027\036\ \027\026\004\017\021\036\035\034\027\t\036 \024\f\035\024\032\027\036\027\ \017\016 )Tj 0.164 Tw T* [(\(Cl)-16(av)-15.9(ien\226Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC (\234)Tj /Span<>> BDC ( )Tj EMC (2\), \026)Tj /Span<>> BDC ( )Tj EMC (\031 4)Tj /Span<>> BDC ( )Tj EMC (\(6,6%\) \023\026\006\017\036\027\021\024\r \030\026\r\017)Tj 0 Tw (-)Tj 0.18 Tw T* [(\035\017\f\034 \f\036\030\034\036\027\t\036 \024\f\035\024\032\027\036\027\ \017\016 )0.5(\(Cl)-16(av)-16(ien\226Dind)-16(o 3\026-3b\). )]TJ 0.146 Tw T* (\215\024\r\021\024\030\027\026\016 \030\036\035\026\023\026\030\024\f\022\ \024\023\017\016 \023\024\021\030\036\002\024\r\026\035\026\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 )Tj 0.125 Tw T* (\023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\030\024\024\n \f\017\020\n\024\f\021\024\n\t, \017)Tj /Span<>> BDC ( )Tj EMC (\031 \007\030\031\020\024\020\024 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.162 Tw T* [(\b\026\027\017\004\036\f\022\024\005 \021\024\027\022\024\022\017\001\036\ \004\027\024\005 )0.5(\027\036\023\030\024\b\024\007\017\n\024\f\021\034\033 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.143 Tw T* (\027\036\027\017\036\n \n\024\004\036\021\024\004\027\017\022\026. \221\026\ \022\032\036 \007\r\031\n \023\026\006\017\036\027\021\026\n \023\024\021\ \030\036)Tj 0 Tw (-)Tj 0.16 Tw T* [(\002\024\r\026\035\026\f\034 )0.5(\027\036\022\030\220\022\021\024\n\017\016 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 11.223 0 Td [(\023\024\r\024\007\031 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\030\026\027\t )]TJ 0.134 Tw -11.223 -1.218 Td (\023\030\024\n\036\032\027\024\f\021\017. \216\017\030\031\030\020\017\004\ \036\f\022\017\036 \030\036\031\035\034\021\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036)Tj 0 Tw (-)Tj T* (\030\017\f\021\017\022\017 \024\023\031\b\024\035\036\005 \023\030\036\007\ \f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\221\026\002\035. 1.)Tj /T1_2 1 Tf 0 -2.436 TD (\017\003\240\004\f\221\b\b\013\r \006\r\213\210\f\001\003\004\003\013)Tj /T1_1 1 Tf 0.182 Tw 0 -1.218 TD (\204\036\007\017\026\027\026 \027\026\002\035\033\007\036\027\017\016 \f\ \024\f\021\026\r\017\035\026 35,9 \n\036\f\016\006\036\r \(95% )Tj 0.031 Tw T* (\212\230: 25,3\22646,6\). \204\036\007\017\026\027\026 \210\200 \f\024\f\ \021\026\r\017\035\026 71,50 \n\036\f\016\006\036\r )Tj -0.119 Tw T* ([95% \212\230: 43,50\22699,60]. \210\002\013\026\016 3-\035\036\021\027\016\ \016 \r\t\032\017\r\026\036\n\024\f\021\034 )Tj 0 Tw T* (\f\024\f\021\026\r\017\035\026 66,50% \(95% \212\230 54,0\22681,90%\). \221\ \030\036\b\035\036\021\027\016\016 )Tj 0.089 Tw T* [(\024\002\013\026\016 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )0.6(\(\210\200\) )0.6(\f\024\f\021\026\r\017\035\026 )0.5(\007\035\016 )0.6(\030\036\006\017\007\017\r\024\r )]TJ 0.086 Tw T* (74,30% \(95% \212\230 59,31\22693,04%\) \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \027\036\023\024\035\027\024\020\024 \024\021)Tj 0 Tw (-)Tj -0.043 Tw T* (\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\216\214\221 56,40% \(95% \212\230 37,90\22684,00%\). \217\026\035\017\004\ \017\016 )Tj 0.39 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \r\t\032\017\r\026\036\n\024\f\021\017 \002\t\035\017\ \027\036\007\024\f\021\024\r\036\030\027\t. \(HR )Tj 0.227 Tw 23.244 64.543 Td (1,80; 95% \212\230: 0,70\2264,60; )Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.227 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,2\). \221\030\036\b\035\036\021\027\016\016 \r\t)Tj 0 Tw (-)Tj 0.152 Tw T* (\032\017\r\026\036\n\024\f\021\034 \002\036 \023\030\024\020\030\036\f\f\ \017\030\024\r\026\027\017\016 \(\200\207\215\) \f\024\f\021\026\r\017\035\ \026 )Tj 0.071 Tw T* (55,40% \(95% \212\230 43,20\22671,10%\). \221\030\036\b\035\036\021\027\016\ \016 \200\207\215 \f\024)Tj 0 Tw (-)Tj 0.058 Tw T* (\f\021\026\r\017\035\026 63,10% \(95% \212\230 47,37\22683,74%\) \007\035\ \016 \030\036\006\017\007\017)Tj 0 Tw (-)Tj 0.019 Tw T* (\r\024\r \017)Tj /Span<>> BDC ( )Tj EMC (46,10% \(95% \212\230 29,2\22672,5%\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \027\036\023\024\035\027\024\020\024 )Tj 0.195 Tw T* [(\024\021\r\036\021\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.493 0 Td [(\216\214\221. )0.5(\217\026\035\017\004\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.431 0 Td [(\r\t\032\017\r\026\036\n\024\f\021\017 )0.6(\002\036 )0.5(\023\030\024)]TJ 0 Tw (-)Tj -0.036 Tw -11.924 -1.218 Td (\020\030\036\f\f\017\030\024\r\026\027\017\016 \002\t\035\017 \027\036\007\ \024\f\021\024\r\036\030\027\t \(HR 1,70; 95% \212\230: )Tj 0 Tw T* (0,69\2264,48; )Tj /T1_3 1 Tf 4.479 0 Td (\032)Tj /T1_1 1 Tf 0.009 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.461 0 Td [(0,18\). \202\027\026\035\017 )0.5(\r\t\032\017\r\026\036\n\024\f\021\017 \023\030\036\007\f\021\026\r)]TJ 0 Tw (-)Tj -5.94 -1.218 Td (\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\036 1.)Tj 0.318 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \n\027\024\020\024\235\026\ \022\021\024\030\027\024\020\024 \026\027\026\035\017\026 \023\024\022\026\ \026)Tj 0 Tw (-)Tj 0.291 Tw T* (\021\036\035\016\n\017, \027\036\020\026\021\017\r\027\024 \r\035\017\016\ \033\013\017\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\t\032\017\r\026)Tj 0 Tw (-)Tj 0.296 Tw T* (\036\n\024\f\021\034, \024\022\026\026\035\017\f\034 \235\024\030\n\026\ \026\002\024\035\036\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\024\007\024\035)Tj 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\032\036\027\027\t\005 \030\024\f\021 \(HR2,70; 95% \212\230: 0,98\2267,\ 92; )Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.114 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\), )Tj 0.029 Tw 0 -1.218 TD (\027\026\030\031\001\036\027\017\036 \030\036\032\017\n\026 \216\214\221\ \(HR 2,80; 95% \212\230: 1,03\2267,62; )Tj /T1_3 1 Tf 0 Tw 0 -1.218 TD (\032)Tj /T1_1 1 Tf 0.052 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\). \221\026\022\032\036 \002\035\017\022\017\n \022)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\n\ \031 )Tj 0.095 Tw T* (\002\t\035\024 \023\024\030\026\032\036\027\017\036 \030\036\020\017\024\ \027\026\030\027\t\b \035\017\n\235\026\021\017\004\036\f\022\017\b \031\ \035\024\r )Tj 0.04 Tw T* (\(HR 2,70; 95% \212\230: 0,86\2268,57; )Tj /T1_3 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.04 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,08\). \203\026\035\017\004\017\036 \030\036\022)Tj 0 Tw (-)Tj 0.195 Tw T* (\021\024\r\026\020\017\027\026\035\034\027\024\020\024 \f\r\017\013\026 \ \031)Tj /Span<>> BDC ( )Tj EMC (\032\036\027\013\017\027, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \024\007\027\024)Tj 0 Tw (-)Tj -0.017 Tw T* (\235\026\022\021\024\030\027\024\020\024 \026\027\026\035\017\026, \f\021\ \026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \f\027\017\ \032\026\035\024 )Tj 0.066 Tw T* [(\024\002\013\031\033 \r\t\032\017\r\026\036\n\024\f\021\034 \(HR )0.5(6,20; 95% )0.5(\212\230: 2,10\22618,80; )]TJ /T1_3 1 Tf 0 Tw T* (\032)Tj /T1_1 1 Tf 0.104 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\). \203\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \r\035\017\016\ \027\017\016 \023\024\035\026, \235\024\030\n\t )Tj 0.164 Tw T* (\026\002\024\035\036\r\026\027\017\016 \(\030\036\006\017\007\017\r/\023\ \030\024\007\024\035\032\036\027\027\t\005 \030\024\f\021\), \002\036\030\ \036)Tj 0 Tw (-)Tj -0.002 Tw T* (\006\017\007\017\r\027\024\020\024 \017\027\021\036\030\r\026\035\026, \027\ \026\035\017\004\017\016 \027\026\030\031\032\027\024\020\024 \022\017\001\ \036\004\027\024\020\024 )Tj 0.007 Tw T* (\f\r\017\013\026, \n\036\f\021\027\024\030\026\f\023\030\024\f\021\030\026\ \027\036\027\027\024\020\024 \b\026\030\026\022\021\036\030\026 \024\023\ \031\b\024\035\017, )Tj -0.01 Tw T* [(\027\036\024\026\007\255\033\r\026\027\021\027\024\005 )0.6(\b\017\n\017\024\021\036\030\026\023\017\017, )0.6(\030\026\n\036\030\026 )0.5(\030\036\006\017\007\017\r\027\024\005 )]TJ 0.045 Tw T* (\024\023\031\b\024\035\017, \030\026\007\017\022\026\035\034\027\024\f\021\ \017 \024\023\036\030\026\006\017\017 \(R0/R1\) \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 )Tj -0.027 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\034. \200\035\017\016\027\017\036 \235\ \026\022\021\024\030\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\t\032\017\r\026)Tj 0 Tw (-)Tj T* (\036\n\024\f\021\034 \023\030\036\007\f\021\026\r\035\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 2 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \030\017\f\031\027\022\036 2.)Tj 0.076 Tw T* (\215\030\017 \n\027\024\020\024\235\026\022\021\024\030\027\024\n \026\027\ \026\035\017\036 \027\036\020\026\021\017\r\027\t\n \235\026\022\021\024\ \030\024\n )Tj 0.026 Tw T* (\002\t\035\024 \027\026\030\031\001\036\027\017\036 \030\036\032\017\n\026\ \216\214\221, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\n \235\026\022)Tj 0 Tw (-)Tj -0.045 Tw T* (\021\024\030\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021\f\031\021\f\021\r\017\036 \023\024\030\026\032\036\027\017\ \016 \035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\024\r )Tj 0.246 Tw T* (\030\036\006\017\007\017\r\027\024\005 \024\023\031\b\024\035\017. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\235\026\022\021\024\030\027\024\n \026\027\026\035\017\ \036 )Tj -0.025 Tw T* (\021\026\022\032\036 \024\021\n\036\004\036\027\024, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036\n \030\036\032\017)Tj 0 Tw (-)Tj 0.068 Tw T* (\n\026 \216\214\221 \023\024\022\026\026\021\036\035\017 3-\b \035\036\021\ \027\036\005 \210\200 \002\t\035\017 \027\017\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj 0.023 Tw T* (\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \035\036\004\036\027\017\036 \023\030\024\r\024\ \007\017\035\026\f\034 )Tj 0.532 Tw T* (\f\024\020\035\026\f\027\024 \022\035\017\027\017\004\036\f\022\017\n \030\ \036\022\024\n\036\027\007\026\006\017\016\n)Tj /Span<>> BDC ( )Tj EMC (\227 45,8% )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (78,2%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj /T1_2 1 Tf 0 -2.436 TD (\200\006\002\n\006\r\217\217\t\006\002\004\b\t\r \212\002\217\f\r \224\200\ \231)Tj /T1_1 1 Tf 0.02 Tw 0 -1.218 TD (\210\002\013\026\016 \004\026\f\021\024\021\026 \023\030\024\020\030\036\ \f\f\017\030\024\r\026\027\017\016 \026\002\024\035\036\r\026\027\017\016\ \023\024\f\035\036 )Tj 0.112 Tw T* (\207\215\233 \f\024\f\021\026\r\017\035\026 26/61 \(42,6%\). \211)Tj /Span<>> BDC ( )Tj EMC (16)Tj /Span<>> BDC ( )Tj EMC (\(26,2%\) \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.2 Tw T* (\021\024\r \030\026\r\017\035\f\016 \023\024\r\021\024\030\027\t\005 \035\ \024\022\026\035\034\027\t\005 \030\036\006\017\007\017\r \023\024\f\035\ \036 )Tj -0.019 Tw T* [(\207\215\233. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.973 0 Td [(\220\021\024\n )0.5(3)]TJ /Span<>> BDC ( )Tj EMC 2.822 0 Td [(\(4,9%\) )0.5(\023\026\006\017\036\027\021\024\r )0.5(\002\t\035\017 )0.5(\024\023\036\030\017\030\024\r\026\027\t )]TJ 0.159 Tw -6.795 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\035\034\027\t\b \022\035\017\027\017\022\026\ \b. \211)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.111 Tw T* [(\021\024\022\024\035\026\b \024\023\036\030\026\006\017\005 \027\036 \002\ \t\035\024 )0.5(\031\022\026\026\027\017\016 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036 )Tj 0.096 Tw T* (\220\022\f\021\030\026\035\036\r\026\021\024\030\027\024\005 \207\215\233\ \(\004\021\024 \002\t\035\024 \023\030\024\r\036\007\036\027\024 \r\024\ \r\f\036\b )Tj 0.076 Tw T* (\f\035\031\004\026\016\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\203\204\230\037\), \031)Tj /Span<>> BDC ( )Tj EMC (1 \023\026\006\017\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.319 Tw T* (\021\024\022\024\035\036 \024\023\036\030\026\006\017\017 \002\t\035\024\ \031\022\026\026\027\024 \031\007\026\035\036\027\017\036 \024\023\031\ \b\024\035\017 )Tj 0.224 Tw T* (\253\022\031\f\022\024\r\026\027\017\036\n\273. \222\030\036\007\017 \024\ \023\036\030\017\030\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\203\204\230\037 \023\026)Tj 0 Tw (-)Tj 0.424 Tw T* (\006\017\036\027\021\024\r \004\026\f\021\024\021\026 \023\024\r\021\024\ \030\027\t\b \030\036\006\017\007\017\r\024\r \f\024\f\021\026\r\017\035\ \026 )Tj 0.089 Tw T* (13)Tj /Span<>> BDC ( )Tj EMC (\(22,4%\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\f\021\024\021\026 \030\036\006\017\007\017\r\024\ \r \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \024\023\036)Tj 0 Tw (-)Tj 0.055 Tw T* (\030\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 9)Tj /Span<>> BDC ( )Tj EMC (\(15,5%\). \210\f\021\026\035\034\027\t\036 \023\024\r\021\024\030\027\t\ \036 \030\036\006\017\007\017\r\t )Tj 0.127 Tw T* (\030\026\r\017\r\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\t\b \017\035\017 \023\026\b\024\r\t\b \035\017\n\235\026\ \021\017\004\036\f\022\017\b )Tj 0.263 Tw T* (\031\035\026\b. \200)Tj /Span<>> BDC ( )Tj EMC (\023\026\b\024\r\t\b \035\017\n\235\026\021\017\004\036\f\022\017\b \031\ \035\026\b \023\024\r\021\024\030\027\t\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.8145 56.0378 Tm (23)Tj ET endstream endobj 1666 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (\201\007\t\215\t\217\007\006\n\220\235\004\n \003\n\006\n\005\007\n)Tj /T1_1 1 Tf -0.023 Tw 0 -1.218 TD (\200\f\036 \023\026\006\017\036\027\021\t, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\024\r\036\007\036\027\017\036 \024\023\ \036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.1 Tw T* [(\201\n\036 R0 )0.5(\f\004\017\021\026\035\024\f\034 )0.5(\r\t\023\024\035\027\017\n\t\n )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\001\036\027\017\033 )0.5(\024\027\022\024\035\024)]TJ 0 Tw (-)Tj -0.019 Tw T* (\020\017\004\036\f\022\024\020\024 \022\024\027\f\017\035\017\031\n\026,\ \023\024\007\r\036\030\020\026\035\017\f\034 \b\017\030\031\030\020\017\ \004\036\f\022\024\n\031 )Tj 0.218 Tw T* (\035\036\004\036\027\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \220\022\f\021\030\026\035\036\r\026\021\024\030\027\ \024\005 \207\215\233. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.266 Tw T* (\024\002\b\024\007\017\n\024\f\021\017 \r\t\023\024\035\027\016\035\026\f\ \034 \n\031\035\034\021\017\r\017\f\006\036\030\026\035\034\027\026\016 \ \030\036)Tj 0 Tw (-)Tj 0.282 Tw 0 -1.218 TD (\036\022\006\017\016. \003\026\022\030\t\021\017\036 \030\026\027\t \023\ \030\024\n\036\032\027\024\f\021\017 \r\t\023\024\035\027\016\035\024\f\034\ )Tj 0.007 Tw 0 -1.218 TD (\n\036\f\021\027\t\n\017 \021\022\026\027\016\n\017, VRAM-\035\024\f\022\ \031\021\024\n \017\035\017 V-Y \035\024\f\022\031\021\024\n. )Tj 0.38 Tw T* (\215\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 \024\f\035\ \024\032\027\036\027\017\016 \022\035\026\f\f\017\235\017\006\017\030\024\ \r\026)Tj 0 Tw (-)Tj -0.072 Tw T* [(\035\017\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.665 0 Td [(\f\024\024\021\r\036\021\f\021\r\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 6.223 0 Td [(\022\035\026\f\f\017\235\017\022\026\006\017\036\005 )0.5(Cl)-16(av)-16(ien\226Dind)-15.9(o.)]TJ /T1_0 1 Tf 0 Tw -8.888 -2.436 Td (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.473 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\017\005 )0.6(\026\027\026\035\017 )0.6(\002\t\035 )0.5(\r\t\023\024\035\027\036\027 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.887 0 Td (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.427 Tw -18.887 -1.218 Td [(\024\r\026\027\017\036\n SPS)17(S S)15(t)15(a)15(t)-32(ist)-32(ics \r\036\030\f\017\017 25 \(IBM, \222\231\202\). )]TJ 0.491 Tw 0 -1.218 TD [(\203\036\023\030\036\030\t\r\027\t\036 \007\026\027\027\t\036 )0.5(\024\023\017\f\t\r\026\035\017 \n\036\007\017\026\027\024\005 \(Me\) )]TJ 0.517 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\021\036\030\022\r\026\030\021\017\035\034\027\t\n )0.5(\030\026\n\026\b\024\n \(IQR\), \022\026\004\036\f\021\r\036\027)]TJ 0 Tw (-)Tj 0.235 Tw T* (\027\t\036)Tj /Span<>> BDC ( )Tj EMC (\227 \026\002\f\024\035\033\021\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017\021\036\035\034\027\t\n\017 \004\026\f\021\024\021\ \026\n\017 )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf 0.267 Tw ( \(%\)\). \204\036\007\017\026\027\031 \027\026\002\035\033\007\036\027\017\ \016 \024\006\036\027\017\r\026\035\017 \n\036\021\024\007\024\n )Tj 0.263 Tw T* (\024\002\030\026\021\027\024\020\024 \025\026\023\035\026\027\026\226\204\ \026\005\036\030\026. \202\027\026\035\017 \r\t\032\017\r\026\036\n\024\ \f\021\017 )Tj 0.198 Tw T* [(\023\030\024\r\024\007\017\035\f\016 \n\036\021\024\007\024\n )0.5(\025\026\023\035\026\027\026\226\204\026\005\036\030\026, \026)]TJ /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\r\024\005 )Tj 0.273 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\030\031\023\023\024\r\024\005 \026\027\026\035\017 \023\ \030\024\r\024\007\017\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.436 Tw T* (\027\017\036\n \035\024\020-\030\026\027\020\024\r\t\b \021\036\f\021\024\ \r. \210\002\013\031\033 \r\t\032\017\r\026\036\n\024\f\021\034 )Tj 0.437 Tw T* (\030\026\f\f\004\017\021\t\r\026\035\017 \f\024 \007\027\016 \b\017\030\031\ \030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.252 Tw T* (\f\021\r\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\t \f\n\036\030\021\017 \017\035\017 \023\024\f\035\036\007\027\ \036\020\024 \027\026\002\035\033\007\036\027\017\016. )Tj -0.02 Tw T* (\215\024\022\026\026\021\036\035\017 \r\t\032\017\r\026\036\n\024\f\021\ \017 \002\036 \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016\ \023\024)Tj 0 Tw (-)Tj 0.074 Tw T* (\f\035\036 \207\215\233 \030\026\f\f\004\017\021\t\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\t \007\017\026\020\027\024\f\021\017\022\017 \030\036\006\017\ \007\017\r\026 )Tj 0.022 Tw T* (\215\217\202\025 \007\024)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\017, \017\035\017 \026\030\036\020\017\f\021\030\017\030\ \024\r\026\027\027\024\020\024 \030\036\006\017\007\017\r\026, )Tj 0.183 Tw T* (\017\035\017 \024\021\007\026\035\036\027\027\024\020\024 \n\036\021\026\ \f\021\026\017\030\024\r\026\027\017\016. \207\t\035\017 \023\030\024\r\ \036\007\036)Tj 0 Tw (-)Tj 0.22 Tw T* (\027\t \024\007\027\024- \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\t\036 \026\027\026\035\017\ \t \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \r\t)Tj 0 Tw (-)Tj 0.508 Tw T* [(\016\r\035\036\027\017\016 )0.6(\023\026\030\026\n\036\021\030\024\r, )0.5(\023\024\021\036\027\006\017\026\035\034\027\024 )0.6(\024\022\026\t\r\026\033\013\017\b )]TJ 0.117 Tw T* (\r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\t\032\017\r\026\036\n\024\f\021\034 \023\031\021\ \036\n \023\024\f\021\030\024\036\027\017\016 )Tj -0.009 Tw T* [(\n\024\007\036\035\017 \023\030\024\023\024\030\006\017\024\027\026\035\034\ \027\t\b \030\017\f\022\024\r \(ha)-24(zar)-24(dr)-33(a)15(t)-31.9(io \(HR\)\) )]TJ 0.136 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034\027\024\020\024 \017\027\021\036\ \030\r\026\035\026 \(\212\230\) \n\036\021\024\007\024\n \030\036)Tj 0 Tw (-)Tj 0.049 Tw T* (\020\030\036\f\f\017\017 \025\024\022\f\026. \217\026\035\017\004\017\016\ \f\004\017\021\026\035\017 \f\021\026\021\017\f\021\017\004\036\f\022\017\ \027\026)Tj 0 Tw (-)Tj 0.081 Tw T* (\004\017\n\t\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.081 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \212\035\016 \n\027\024\020\024\235\026\022\021\024\030\027\024\020\ \024 \026\027\026\035\017\026 )Tj 0 Tw T* (\002\t\035\017 \r\t\002\030\026\027\t \022\024\r\026\030\017\026\021\t \f\ )Tj /Span<>> BDC ( )Tj EMC 11.547 0 Td [(\021\036\027\007\036\027\006\017\036\005 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\027\026\004\017\n\024\f\021\017 )Tj -11.547 -1.218 Td (\()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf 0.082 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,2\). \210\023\017\f\026\021\036\035\034\027\026\016 \f\021\026\021\017\ \f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\017\f\021\017\004\036\f\022\017\005 )Tj 0.436 Tw T* (\026\027\026\035\017 \002\t\035\017 \r\t\023\024\035\027\036\027\t \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n SPS)17(S )]TJ 0 Tw T* [(S)15(t)15(a)15(t)-32(ist)-32(ics \r\036\030\f\017\017 25 \(IBM, \222\231\202\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 225.5318 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.147 Tw 10 0 0 10 70.8661 201.1758 Tm (\200 \023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2013 \023\024)Tj /Span<>> BDC ( )Tj EMC (2024 \020\020. 61 \023\026\006\017\036\027\021\031 \r\t\023\024\035\027\036\ )Tj 0 Tw (-)Tj 0.094 Tw T* (\027\026 \207\215\233 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\035\024\f\022\024\022\035\036\021\024\004\027\ \024\020\024 \030\026\022\026 \026\027\026\035\034\027\024\020\024 )Tj 0.197 Tw T* (\022\026\027\026\035\026, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\036\006\017\007\017\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 34)Tj /Span<>> BDC ( )Tj EMC (\(55,7%\), )Tj 0.169 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \027\036\023\024\035\027\024\020\024 \024\021\r\036\ \021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\216\214\221)Tj /Span<>> BDC ( )Tj EMC (\227 27)Tj /Span<>> BDC ( )Tj EMC (\(44,3%\). )Tj -0.06 Tw 0 -1.218 TD [(\216\026\030\026\022\021\036\030\017\f\021\017\022\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\023\030\036\007\f\021\026\r\035\036\027\t )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.825 0 Td (\021\026\002\035\017\006\036)Tj /Span<>> BDC ( )Tj EMC 3.489 0 Td (1.)Tj 1.021 Tw -21.314 -1.218 Td (\222\030\036\007\017 \023\026\006\017\036\027\021\024\r \023\030\036\024\ \002\035\026\007\026\035\017 \032\036\027\013\017\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.035 Tw 0 -1.218 TD (53)Tj /Span<>> BDC ( )Tj EMC [(\(86,9%\). )0.5(\204\036\007\017\026\027\026 )0.5(\r\024\030\026\f\021\026 \023\026\006\017\036\027\021\024\r )0.5(\002\t\035\026 )0.5(\030\026\r\027\026 )]TJ 0.122 Tw 0 -1.218 TD [(58 \(Q1\226Q3:50\22670\). \215\024\030\026\032\036\027\017\036 \030\036\020\ \017\024\027\026\030\027\t\b )0.5(\035\017\n\235\026)]TJ 0 Tw (-)Tj 0.127 Tw 0 -1.218 TD (\021\017\004\036\f\022\017\b \031\035\024\r, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \023\026\021\024\035\024\020\024\026\027\026\021\024\ \n\017\004\036\f\022\024\020\024 )Tj 0.102 Tw 0 -1.218 TD (\017\f\f\035\036\007\024\r\026\027\017\016, \026\030\036\020\017\f\021\030\ \017\030\024\r\026\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\) \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.129 Tw 0 -1.218 TD (\021\024\r. \222\030\036\007\017 \023\024\030\026\032\036\027\027\t\b \020\ \030\031\023\023 \035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\ \024\r )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.043 Tw 9 0 0 9 303.3071 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\022 \033\020\006\022\027\ \025\023\031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\031\033\r\200\031\f\027\235 \030\031)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\033\031)Tj 0 Tw (-)Tj 0 -1.2 TD (\024\f\027 \240\032\005\213\025\031-\033\032\031\026\027\255\025\031\024\ \023\025\031\235 \204\n\024\023\022\032\033\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.175 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.148 Tw 3.471 0 Td [( P)25.9(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t a)-5.1(n)-4.8(d t)-1.1(u)0.6(m)-5.2(o)-3(r c)-2.5(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-38.9(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s b)-10.1(ef)-13.4(o)-3(r)-1.9(e a)-5(n)-4.8(d a)-0.6(f)-50.9(t)-1.6(e)-6(r )]TJ 0 Tw -3.471 -1.2 Td [(a)-0.9(b)-10.1(d)-5.3(o)-4(m)1.4(i)3.9(n)-2.4(o)-5.3(p)-11.3(e)-6(r)-39(i)3.9(n)-2.4(e)-7.5(a)-4.4(l r)-2(e)-22(s)0.5(e)-10.9(c)-32.4(t)-29.1(i)-1.4(o)-4(n \()29.7(N)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(6)46(1)84.6(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 693.581 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 677.0143 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 476.4705 693.581 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 677.0143 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 524.6594 677.0143 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 303.3071 676.7643 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 668.1976 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 676.7643 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 668.1976 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 667.9476 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 659.3879 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 667.9476 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 659.3879 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 659.3879 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 659.1379 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 650.5782 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 659.1379 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 650.5782 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 650.5782 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 650.3282 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 641.7615 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 650.3282 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 641.7615 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 524.6594 641.7615 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 641.5115 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 632.9449 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 641.5115 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 632.9449 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 632.6949 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 624.1351 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 632.6949 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 624.1351 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 624.1351 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 623.8851 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 615.3254 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 623.8851 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 615.3254 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 615.3254 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 615.0754 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 606.5157 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 615.0754 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 606.5157 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 606.5157 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 606.2657 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 597.706 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 606.2657 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 597.706 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 597.706 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 597.456 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 588.8893 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 597.456 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 588.8893 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 588.6393 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 580.0796 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 588.6393 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 580.0796 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 580.0796 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 579.8296 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 571.2698 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 579.8296 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 571.2698 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 571.2698 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 571.0198 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 562.4601 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 571.0198 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 562.4601 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 562.4601 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 562.2101 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 553.6434 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 562.2101 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 553.6434 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 553.3934 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 544.8337 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 553.3934 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 544.8337 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 544.8337 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 544.5837 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 536.024 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 544.5837 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 536.024 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 536.024 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 535.774 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 527.2073 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 535.774 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 527.2073 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 526.9573 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 518.3976 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 526.9573 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 518.3976 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 518.3976 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 518.1476 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 509.5879 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 518.1476 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 509.5879 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 509.5879 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 509.3379 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 492.7712 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 476.4705 509.3379 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 492.7712 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 524.6594 492.7712 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 303.3071 492.5212 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 483.9545 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 492.5212 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 483.9545 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 483.7045 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 475.1448 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 483.7045 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 475.1448 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 475.1448 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 474.8948 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 466.3351 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 474.8948 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 466.3351 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 466.3351 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 466.0851 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 457.5254 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 466.0851 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 457.5254 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 457.5254 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 457.2754 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 448.7087 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 457.2754 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 448.7087 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 448.4587 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 439.899 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 448.4587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 439.899 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 439.899 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 439.649 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 431.0893 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 439.649 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 431.0893 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 431.0893 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 430.8393 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 422.2795 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 430.8393 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 422.2795 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 422.2795 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 422.0295 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 413.4629 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 422.0295 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 413.4629 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 413.2129 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 404.6531 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 413.2129 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 404.6531 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 404.6531 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 404.4031 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 395.8434 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 404.4031 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 395.8434 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 395.8434 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 395.5934 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 387.0337 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 395.5934 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 387.0337 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 387.0337 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 386.7837 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 378.217 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 386.7837 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 378.217 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 377.967 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 369.4073 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 377.967 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 369.4073 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 369.4073 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 369.1573 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 360.5976 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 369.1573 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 360.5976 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 360.5976 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 360.3476 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 351.7809 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 360.3476 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 351.7809 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 351.5309 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 342.9712 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 351.5309 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 342.9712 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 342.9712 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 342.7212 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 334.1614 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 342.7212 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 334.1614 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 334.1614 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 333.9114 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 325.3517 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 333.9114 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 325.3517 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 325.3517 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 325.1017 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 316.5351 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 325.1017 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 316.5351 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 316.2851 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 307.7253 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 316.2851 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 307.7253 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 307.7253 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 307.4753 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 298.9156 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 307.4753 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 298.9156 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 298.9156 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 298.6656 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 290.1059 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 298.6656 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 290.1059 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 290.1059 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 289.8559 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 281.2961 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 289.8559 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 281.2961 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 281.2961 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 281.0461 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 272.4864 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 281.0461 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 272.4864 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 272.4864 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 272.2364 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 263.6698 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 272.2364 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 263.6698 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 263.4198 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 254.86 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 263.4198 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 254.86 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 254.86 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 254.61 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 246.0503 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 254.61 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 246.0503 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 246.0503 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 245.8003 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 237.2406 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 245.8003 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 237.2406 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 237.2406 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 236.9906 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 228.4239 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 236.9906 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 228.4239 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 524.6594 228.4239 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 228.1739 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 219.6142 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 228.1739 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 219.6142 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 219.6142 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 219.3642 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 210.8045 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 219.3642 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 210.8045 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 210.8045 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 210.5545 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 201.9947 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 210.5545 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 201.9947 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 201.9947 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 201.7447 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 193.1781 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 201.7447 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 193.1781 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 192.9281 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 176.3683 cm 0 0 m 0 16.31 l S Q q 1 0 0 1 476.4705 192.9281 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 176.3683 cm 0 0 m 0 16.31 l S Q q 1 0 0 1 524.6594 176.3683 cm 0 0 m 0 16.31 l S Q q 1 0 0 1 303.3071 176.1183 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 159.5517 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 476.4705 176.1183 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 159.5517 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 524.6594 159.5517 cm 0 0 m 0 16.317 l S Q q 1 0 0 1 303.3071 159.3017 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 150.735 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 159.3017 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 150.735 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 150.485 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 141.9253 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 150.485 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 141.9253 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 141.9253 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 141.6753 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 133.1155 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 141.6753 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 133.1155 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 133.1155 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 132.8655 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 124.3058 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 132.8655 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 124.3058 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 124.3058 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 124.0558 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 115.4891 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 124.0558 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 115.4891 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 524.6594 115.4891 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 115.2391 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 106.6725 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 115.2391 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 106.6725 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 524.6594 106.6725 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 106.4225 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 97.8558 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 476.4705 106.4225 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 524.6594 97.8558 cm 0 0 m 0 8.317 l S Q q 1 0 0 1 303.3071 97.6058 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 89.0461 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 97.6058 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 89.0461 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 89.0461 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 88.7961 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 303.5571 80.2364 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 476.4705 88.7961 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 80.2364 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 524.6594 80.2364 cm 0 0 m 0 8.31 l S Q q 1 0 0 1 303.3071 79.9864 cm 0 0 m 173.163 0 l S Q q 1 0 0 1 476.4705 79.9864 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_4 1 Tf 7 0 0 7 372.3635 682.6351 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 16.131 0.571 Td (\200\004\204\t\r\b\003\013 )Tj -0.833 -1.143 Td (\217)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\021 N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61)Tj -24.723 -1.26 Td (\200\002\f )Tj /T1_1 1 Tf 0 -1.259 TD (\n\031\032\004\017\027\t )Tj 25.781 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13,1%\))Tj -25.781 -1.259 Td (\032\036\027\013\017\027\t )Tj 25.531 0 Td (53)Tj /Span<>> BDC ( )Tj EMC (\(86,9%\))Tj /T1_4 1 Tf -25.531 -1.26 Td (\026\002\213\006\004\217\003 \(\214\r\240\t\004\b\004 \(Q1-Q3\)\))Tj /T1_1 1 Tf 25.577 0.001 Td (58)Tj /Span<>> BDC ( )Tj EMC (\(50-70\))Tj /T1_4 1 Tf -25.577 -1.261 Td (\255\003\004\240\t\235 \212\002)Tj /Span<>> BDC ( )Tj EMC (\220\006\t\003\r\006\t\211 \020 \212\r\006\t\201\b\002\005 \002\212\210\ \216\002\f\t)Tj /T1_1 1 Tf 0 -1.259 TD (\2211 )Tj 26.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\))Tj -26.031 -1.259 Td (\2212 )Tj 25.531 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(49,1%\))Tj -25.531 -1.259 Td (\2213 )Tj 25.531 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(22,9%\))Tj -25.531 -1.259 Td (\2214 )Tj 25.531 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(26,2%\))Tj /T1_4 1 Tf -25.531 -1.26 Td (\255\003\004\240\t\235 \212\002)Tj /Span<>> BDC ( )Tj EMC (\220\006\t\003\r\006\t\211 N \212\r\006\t\201\b\002\005 \002\212\210\216\ \002\f\t)Tj /T1_1 1 Tf 0 -1.259 TD (N0 )Tj 25.531 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(65,6%\))Tj -25.531 -1.259 Td (N1 )Tj 25.531 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(31,1%\))Tj -25.531 -1.259 Td (N2 )Tj 26.031 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,3%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\255\003\004\240\t\235 \212\002)Tj /Span<>> BDC ( )Tj EMC (\220\006\t\003\r\006\t\211 \215)Tj /T1_1 1 Tf T* (\2040)Tj 25.531 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(98,4%\))Tj -25.531 -1.259 Td (\2041)Tj 26.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\215\r\217\003\002 \212\006\002\r\240\r\b\t\235 \225\035\020)Tj /T1_1 1 Tf T* (\205\036\007\036\030\026\035\034\027\t\005 \006\036\027\021\030 )Tj 25.531 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(37,7%\))Tj -25.531 -1.259 Td (\217\036\020\017\024\027\026\035\034\027\t\005 \006\036\027\021\030 )Tj 25.531 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(62,3%\))Tj /T1_4 1 Tf -25.531 -1.26 Td (\255\002\206\f\211\240\r\b\t\r \220\f\t\b\t\201\r\217\220\t\216 \006\r\220\ \002\214\r\b\240\004\204\t\005 )Tj 0 -1.143 TD (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\t\217\216\002\240\b\002\214 \f\r\201\r\b\t\t)Tj /T1_1 1 Tf 25.531 1.144 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(62,3%\))Tj /T1_4 1 Tf -25.531 -2.403 Td (\031\r\226\r\220\003\013 \212\006\002\r\240\r\b\t\235 \225\035\020)Tj /T1_1 1 Tf 0 -1.259 TD (\212\036\235\036\022\021\t \r\t\002\024\030\026 \f\031\n\n\026\030\027\024\ \005 \007\024\t \214\221)Tj 26.031 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj -26.031 -1.259 Td (\203\036\024\002\024\f\027\024\r\026\027\027\t\036 \023\036\030\036\030\t\ \r\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017)Tj 26.031 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\))Tj -26.031 -1.259 Td (\212\036\235\036\022\021\t \023\030\024\r\036\007\036\027\017\016 \216\221\ )Tj 25.781 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(14,8%\))Tj /T1_4 1 Tf -25.781 -1.26 Td (\031\r\226\r\220\003\013 \003\002\212\002\214\r\003\006\t\201\r\217\220\002\ \n\002 \220\004\006\003\t\006\002\004\b\t\235)Tj /T1_1 1 Tf 0 -1.259 TD (\212\036\235\036\022\021\t \024\002\255\036\n\026 \023\036\030\r\017\004\ \027\024\005 \024\023\031\b\024\035\017 \(GTV\))Tj 26.031 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj -26.031 -1.259 Td (\212\036\235\036\022\021\t \022\035\017\027\017\004\036\f\022\024\020\024\ \024\002\255\036\n\026 \024\002\035\031\004\036\027\017\016 \(CTV\))Tj 25.531 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(34,5%\))Tj -25.531 -1.259 Td (\203\036 \024\006\036\027\017\r\026\035\017\f\034)Tj 25.531 0 Td (35)Tj /Span<>> BDC ( )Tj EMC (\(57,3%\))Tj /T1_4 1 Tf -25.531 -1.26 Td (\035\r\220\004\006\217\003\r\b\b\002\r \f\r\201\r\b\t\r \212\r\006\r\240\ \002\212\r\006\004\204\t\r\005 \212\002)Tj /Span<>> BDC ( )Tj EMC (\212\002\002\240\210 \006\r\204\t\240\t\004 )Tj /T1_1 1 Tf 0 -1.259 TD (DCF \(\007\024\006\036\021\026\022\f\036\035, \006\017\f\023\035\026\021\ \017\027 \017)Tj /Span<>> BDC ( )Tj EMC (5-\235\021\024\030\031\030\026\006\017\035\))Tj 26.031 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(6,6%\))Tj -26.031 -1.259 Td (\222F \(\235\021\024\030\031\030\026\006\017\035)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\006\017\f\023\035\026\021\017\027\))Tj 26.031 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj -26.031 -1.259 Td (CP \(\022\026\030\002\024\023\035\026\021\017\027)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\026\022\035\017\021\026\022\f\036\035\))Tj 26.031 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(6,6%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\203\002\006\214\004 \213\004\206\002\f\r\004\b\t\235 )Tj /T1_1 1 Tf T* (\217\036\006\017\007\017\r )Tj 25.531 0 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(55,7%\))Tj -25.531 -1.259 Td (\203\036\023\024\035\027\t\005 \024\021\r\036\021 )Tj 25.531 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(44,3%\))Tj /T1_4 1 Tf -25.531 -1.26 Td (\225\t\006\210\006\n\t\201\r\217\220\t\005 \240\002\217\003\210\212)Tj /T1_1 1 Tf T* (\210\021\022\030\t\021\t\005)Tj 25.531 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(63,9%\))Tj -25.531 -1.259 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005)Tj 25.531 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(34,4%\))Tj -25.531 -1.259 Td (\217\024\002\024\021-\026\f\f\017\f\021\017\030\024\r\026\027\027\t\005)Tj 26.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\225\t\006\210\006\n\t\201\r\217\220\002\r \f\r\201\r\b\t\r )Tj /T1_1 1 Tf 0 -1.259 TD (\207\215\233 )Tj 25.531 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(63,9%\))Tj -25.531 -1.259 Td (\207\215\233)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\016 \026\007\027\036\005 \f\021\036\027\022\017\ \r\035\026\020\026\035\017\013\026 )Tj 25.531 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(27,9%\))Tj -25.531 -1.259 Td (\207\215\233)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\026\016 \035/\026 )Tj 26.031 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,3%\))Tj -26.031 -1.259 Td (\207\215\233)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\026\b\024\r\026\016 \035/\026 )Tj 26.031 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,3%\))Tj -26.031 -1.259 Td (\207\215\233)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\030\036\036\022\006\017\016 \023\036\004\036\027\017)Tj 26.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\033\004\220\006\013\003\t\r \006\004\b\013 \212\006\002\214\r\202\b\002\ \217\003\t )Tj /T1_1 1 Tf T* (\215\036\030\r\017\004\027\024\036 \026\022\030\t\021\017\036 )Tj 25.531 0 Td (58)Tj /Span<>> BDC ( )Tj EMC (\(95,1%\))Tj -25.531 -1.259 Td (V-Y \035\024\f\022\031\021 )Tj 26.031 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,3%\))Tj -26.031 -1.259 Td (VRAM \035\024\f\022\031\021 )Tj 26.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\017\217\f\002\202\b\r\b\t\235 \212\002)Tj /Span<>> BDC ( )Tj EMC (Clavien-Dindo )Tj /T1_1 1 Tf T* (1 )Tj 26.031 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\))Tj -26.031 -1.259 Td (2 )Tj 25.781 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(14,8%\))Tj -25.781 -1.259 Td (3b)Tj 26.031 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(6,6%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\225\004\006\004\220\003\r\006\t\217\003\t\220\t \002\212\210\216\002\f\t\ )Tj /T1_1 1 Tf T* (\217\026\n\036\030 \024\023\031\b\024\035\017, \n\n. \204\036\007\017\026\ \027\026 \(Q1-Q3\))Tj 24.892 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(21,0-50,8\) )Tj 1.57 -1.143 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61)Tj /T1_4 1 Tf -26.462 -1.26 Td (\200\002\006\004\202\r\b\t\r \006\r\n\t\002\b\004\006\b\013\216 \f\t\214\ \226\004\003\t\201\r\217\220\t\216 \210\213\f\002 )Tj 0 -1.143 TD (\212\002)Tj /Span<>> BDC ( )Tj EMC (\240\004\b\b\013\214 \212\004\003\002\f\002\n\002\004\b\004\003\002\214\t\ \201\r\217\220\002\n\002 \t\217\217\f\r\240\002\004\b\t\235 )Tj /T1_1 1 Tf 26.031 1.144 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj /T1_4 1 Tf -26.031 -2.403 Td (\200\002\006\004\202\221\b\b\013\r \n\006\210\212\212\013 \f\t\214\226\004\ \003\t\201\r\217\220\t\216 \210\213\f\002 \006\r\204\t\240\t\b\002\005\ \002\212\210\216\002\f\t )Tj /T1_1 1 Tf 0 -1.259 TD (\204\036\024\030\036\022\021\026\035\034\027\t\036 )Tj 26.031 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(4,9%\))Tj -26.031 -1.259 Td (\215\026\b\024\r\t\036 )Tj 26.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,6%\))Tj -26.031 -1.259 Td (\203\026\030\031\032\027\t\036 \023\024\007\r\007\024\001\027\t\036 )Tj 26.031 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,3%\))Tj /T1_4 1 Tf -26.031 -1.26 Td (\022\r\220\003\002\004\n\t\b\004\f\001\b\013\005 \217\t\227)Tj /T1_1 1 Tf 25.059 0.001 Td (7/53)Tj /Span<>> BDC ( )Tj EMC (\(13,2%\))Tj /T1_4 1 Tf -25.059 -1.261 Td (\025\004\006\210\202\b\013\005 \220\t\230\r\201\b\013\005 \217\t\227)Tj /T1_1 1 Tf 26.031 0.001 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj /T1_4 1 Tf -26.031 -1.261 Td (\021\006\004\005 \006\r\213\r\220\204\t\t)Tj /T1_1 1 Tf T* (R0 )Tj 25.531 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(90,2%\))Tj -25.531 -1.259 Td (R1 )Tj 26.031 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(9,8%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 28.1026 56.0378 Tm (22)Tj ET endstream endobj 1665 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\205\n\005\002\005\013\n\225\004\016\r)10(\025\004 \020\004\225\004\t\n\004 \224\017\n\004\t\026)11(\025\b \016\022\005\004\n\202\n\b\025\024 )]TJ 0 -1 TD [(\224\020\025\016\r)10(\025\r)-9.9(\020\004\026)11(\025\225\t\025\013)10(\025 \005\017\r\017 \017\t\017\020\200\t\025\013)10(\025 \r\017\t\017\020\017)]TJ 41.019 1 Td [(Sur)31(gical tr)31(eatment for patients with per)20.1(sistent and )]TJ 3.771 -1 Td [(r)31(ecurr)31.1(ent s)11(quamous cell anal car)31.1(cinoma)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.012 Tc 1.123 Tw 10 0 0 10 42.5197 700.4739 Tm (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\f\023\036\b\017 \216\214\221 \023\035\024\f\022\024\022\035\036\021\ \024\004\027\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 1.031 Tw 0 -1.218 TD [(\020\024 \030\026\022\026 \026\027\026\035\034\027\024\020\024 \022\026\027\ \026\035\026 \(\215\217\202\025\), \023\024\004\021\017)12( )]TJ 1.008 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\017 \023\026\006\017\036\027\021\024\r \030\026\r\017\r\ \026\036\021\f\016 \023\030\024\020\030\036\f\f\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.102 Tw T* (\030\024\r\026\027\017\036 \024\023\031\b\024\035\036\r\024\020\024 \023\ \030\024\006\036\f\f\026, \004\021\024 \f\r\016\027\024 \f\024 \f\027\017\ )Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.156 Tw T* (\032\036\027\017\036\n \024\002\013\036\005 5-\021\017 \035\036\021\027\036\ \005 \r\t\032\017\r\026\036\n\024\f\021\017 \007\024)Tj /Span<>> BDC ( )Tj EMC [(45%)12( )]TJ 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\006\017\007\017\r\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024)Tj /Span<>> BDC ( )Tj EMC (38,3%)Tj /Span<>> BDC ( )Tj EMC ([1,2,3].)Tj 0 Tc 0.243 Tw 0 -1.218 TD (\200 \217\024\f\f\017\017 \023\030\024\002\035\036\n\026 \023\030\024\020\ \030\036\f\f\017\030\024\r\026\027\017\016 \215\217\202\025 \023\024\f\035\ \036 )Tj 0.21 Tw T* [(\035\036\004\036\027\017\016 )0.5(\n\024\032\036\021 \002\t\021\034 )0.5(\002\024\035\036\036 \026\022\021\031\026\035\034\027\024\005 )0.5(\017-\026 )0.5(\027\036\030\036)]TJ 0 Tw (-)Tj 0.229 Tw T* (\001\201\027\027\024\005 \023\030\024\002\035\036\n\t \f\017\f\021\036\n\ \026\021\017\004\036\f\022\024\020\024 \027\036\f\024\002\035\033\007\036\ \027\017\016 )Tj 0.089 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \030\036\022\024\n\036\027\007\026\ \006\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\020\024 \022\026\004\036\f\021\r\026 \216\214\221. )Tj 0.111 Tw 0 -1.218 TD (\207\t\035\024 \023\024\022\026\026\027\024, \004\021\024 \024\001\017\002\ \022\017 \024\021\n\036\004\026\033\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (84,6% \023\026)Tj 0 Tw (-)Tj 0.053 Tw 0 -1.218 TD (\006\017\036\027\021\024\r, \022\024\021\024\030\t\036 \023\024\035\031\004\ \026\033\021 \035\036\004\036\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \215\217\202\025 )Tj 0 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\035\034\027\t\b \006\036\027\021\030\026\b \ [4].)Tj 0.222 Tw 0 -1.218 TD [(\213\007\017\027\f\021\r\036\027\027\t\n )0.6(\023\024\021\036\027\006\017\026\035\034\027\024 )0.6(\030\026\007\017\022\026\035\034\027\t\n )0.5(\n\036\021\024\007\024\n )]TJ 0.012 Tw 0 -1.218 TD (\035\036\004\036\027\017\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\f\017\f\021\017\030\031\033\013\017\n \026\002\024\035\036\ \r\026\027\017\036\n )Tj 0.202 Tw 0 -1.218 TD [(\017\035\017 )0.5(\030\036\006\017\007\017\r\024\n )0.5(\023\024\f\035\036 )0.6(\b\017\n\017\024\035\031\004\036\r\024\005 )0.6(\021\036\030\026\023\017\017 )0.5(\016\r\035\016)]TJ 0 Tw (-)Tj 0.265 Tw 0 -1.218 TD (\036\021\f\016 \b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\ \004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \220\022\f\021\030\026\035\036\r\026)Tj 0 Tw (-)Tj 0.203 Tw 0 -1.218 TD (\021\024\030\027\024\005 \002\030\033\001\027\024-\023\030\024\n\036\032\ \027\024\f\021\027\024\005 \220\022\f\021\017\030\023\026\006\017\017 \(\ \207\215\233\) )Tj 0 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 [5].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 444.7358 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.259 Tw 10 0 0 10 42.5197 420.3798 Tm (\037\036\035\034\033 \007\026\027\027\024\020\024 \017\f\f\035\036\007\024\ \r\026\027\017\016 \016\r\035\016\036\021\f\016 \026\027\026\035\017 \024\ \027)Tj 0 Tw (-)Tj 0.153 Tw T* (\022\024\035\024\020\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC [(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.5(\030\036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016 )]TJ 0.094 Tw T* (\030\036\006\017\007\017\r\024\r \215\217\202\025 \023\024\f\035\036 \216\ \214\221 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \023\030\024\020\027\024\f\021\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017\b \235\026\022\021\024\030\024\r \024\002\013\036\005\ \r\t\032\017\r\026\036\n\024\f\021\017 \(\210\200\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 347.3118 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.02 Tc 0.161 Tw 10 0 0 10 42.5197 322.9558 Tm (\230\f\f\035\036\007\024\r\026\027\017\036 \024\f\027\024\r\026\027\024 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \017\031)Tj /Span<>> BDC (-)Tj EMC 0.246 Tw T* [(\004\036\027\017\017 \017\f\021\024\030\017\005 \002\024\035\036\027\017\ \023\026\006\017\036\027\021\024\r, \023\030\024\b\024\007\017\r\001\017\ \b)20.1( )]TJ 0.116 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \020\017\f\021\024\035\024\020\017\004\036\f\022\017\ )20( )]TJ 0.245 Tw T* (\023\024\007\021\r\036\030\032\007\036\027\027\024\020\024 \035\024\022\026\ \035\034\027\024\020\024 \030\036\006\017\007\017\r\026 \017\035\017 \023\ \030\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc -0.031 Tw T* (\007\024\035\032\036\027\027\024\020\024 \030\024\f\021\026 \023\035\024\ \f\022\024\022\035\036\021\024\004\027\024\020\024 \030\026\022\026 \026\ \027\026\035\034\027\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc -0.039 Tw T* (\020\024 \022\026\027\026\035\026 \023\024\f\035\036 \030\026\007\017\022\ \026\035\034\027\024\020\024 \022\031\030\f\026 \216\214\221 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\034)20.1( )]TJ 0.036 Tw T* (\023\036\030\r\017\004\027\024\005 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\036\020\017\024\027\026\030\027\t\b \035\017\n\235\026\021\017\004\036\ \f\022\017\b)20( )]TJ 0.066 Tw T* (\031\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\016 2013 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\036\022\026\002\030\034 2024 \020\020.)20( )]TJ 0.031 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.849 0 Td [(\022\026\004\036\f\021\r\036 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016 )0.5(\023\026\006\017\036\027\021\026\n )0.5(\r\t)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.286 Tw -0.849 -1.218 Td [(\023\024\035\027\016\035\026\f\034 \220\022\f\021\030\026\035\036\r\026\021\ \024\030\027\026\016 \207\215\233 \023\030\016\n\024\005 \022\017\001\022\ \017,)20( )]TJ 0.217 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.51 0 Td [(\023\024\022\026\026\027\017\016\n )0.5(\r\024\n\024\032\027\024 )0.5(\002\t\035\024 )0.6(\030\026\f\001\017\030\036\027\017\036 )0.5(\024\002\255)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.222 Tw -1.51 -1.218 Td (\201\n\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\036\036\022\006\017\036\005 \f\024\f\036\007\027\017\b \024\030\020\ \026\027\024\r, \023\026\b\024\r\024\005 \017\035\017)20( )]TJ 0.377 Tw T* (\021\026\024\r\024\005 \035\017\n\235\024\007\017\f\f\036\022\006\017\036\ \005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 \007\026\027\027\t\b)20( )]TJ 0.198 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\017\017 \f\024\024\021\r\036\021\f\021\r\031\ \033\013\017\b \020\030\031\023\023 \035\017\n\235\026\021\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.275 Tw T* (\f\022\017\b \031\035\024\r. \222)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\235\017\035\026\022\021\017\004\036\f\022\024\005 \006\036\035\ \034\033 \021\026\024\r\031\033)20( )]TJ 0.581 Tw T* [(\017\035\017 \023\026\b\024\r\031\033 \035\017\n\235\024\007\017\f\f\036\ \022\006\017\033 \027\036 \r\t\023\024\035\027\016\035\017.)20( )]TJ 0.23 Tw T* [(\210\f\027\024\r\027\t\n \024\006\036\027\017\r\026\036\n\t\n \023\026\030\ \026\n\036\021\030\024\n \002\t\035\026 \024\002\013\026\016)20( )]TJ 0.103 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\034 \(\210\200\). \212\024\023\024\035\ \027\017\021\036\035\034\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \030\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.026 Tw T* (\006\017\007\017\r\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\024\020\024 \024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\216\214\221 \024\006\036\027\017\r\026\035\017 \r\t)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.149 Tw T* [(\032\017\r\026\036\n\024\f\021\034 \002\036 \023\030\024\020\030\036\f\f\ \017\030\024\r\026\027\017\016 \(\200\207\215\), \004\026\f\021\024\021\031\ )20.1( )]TJ 0.055 Tw T* [(R0 \030\036\036\022\006\017\005, \024\f\035\024\032\027\036\027\017\005\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016)20( )]TJ 0.232 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\235\026\022\021\024\030\t \030\017\f\022\026 \030\026\r\017\021\017\016\ \023\024\r\021\024\030\027\024\020\024 \030\036\006\017\007\017\r\026)20( )]TJ 0 Tw 0 -1.218 TD (\023\024\f\035\036 \207\215\233.)Tj 0 Tc 0.164 Tw 0 -1.218 TD [(\025\030\017\021\036\030\017\016\n\017 \027\036\r\022\035\033\004\036\027\ \017\016 )0.5(\002\t\035\024 \027\026\035\017\004\017\036 \027\036\030\036\036\022\021\ \026)]TJ 0 Tw (-)Tj 0.039 Tw 0 -1.218 TD [(\002\036\035\034\027\t\b )0.6(\024\021\007\026\035\201\027\027\t\b )0.5(\n\036\021\026\f\021\026\024\r )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.943 0 Td [(\n\024\n\036\027\021 )0.5(\r\t\023\024\035\027\036)]TJ 0 Tw (-)Tj 0.23 Tw -14.943 -1.218 Td (\027\017\016 \024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \023\036\030\r\017\004\027\024-\n\027\024\032\ \036\f\021\r\036\027\027\t\b )Tj 0 Tw 0 -1.218 TD (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\r\024\024\002\ \030\026\024\r\026\027\017\005.)Tj /T1_3 1 Tf 0 -2.436 TD (\013\n\t\b\007\006\005\004\n \003\n\006\n\005\007\n)Tj /T1_2 1 Tf 0.02 Tc 0.307 Tw 0 -1.218 TD (\217\036\032\017\n \023\036\030\r\017\004\027\024\020\024 \035\036\004\036\ \027\017\016 \027\036 \002\t\035 \030\036\020\035\026\n\036\027\021\017)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.362 Tw T* (\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\026\n\022\026\b \017\f\f\035\036\007\024\r\026\027\017\016. \200\f\036\ \n \023\026\006\017\036\027\021\026\n)20( )]TJ 0.624 Tw T* [(\r\t\023\024\035\027\016\035\017 \026\027\026\035\017 \n\036\007\017\006\ \017\027\f\022\024\005 \007\024\022\031\n\036\027\021\026\006\017\017)20( )]TJ 0.06 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.85 0 Td [(\026\031\007\017\021 )0.6(\021\024\023\024\n\036\021\030\017\004\036\f\022\017\b )0.5(\022\026\030\021, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.739 0 Td [(\031\f\035\024\r\017\017 )0.5(\017\b )0.5(\007\024)]TJ 0 Tc 0 Tw (-)Tj 0.02 Tc 0.025 Tw -15.589 -1.218 Td (\f\021\031\023\027\024\f\021\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \007\026\027\027\024\020\024 \026\027\026\ \035\017\026 \023\026\006\017\036\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.135 Tw 0 -1.218 TD (\021\024\r \030\026\007\036\035\016\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \216\214\221 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\024\002\035\033\007\036\027\017\036\n \017\035\017)20( )]TJ 0.008 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036\n \022\035\017\027\017\004\036\f\022\ \017\b \030\036\022\024\n\036\027\007\026\006\017\005. \215\024\007 \f\024\ )Tj 0 Tc 0 Tw (-)Tj 0.02 Tc -0.046 Tw T* (\002\035\033\007\036\027\017\036\n \022\035\017\027\017\004\036\f\022\017\ \b \030\036\022\024\n\036\027\007\026\006\017\005 \023\024\007\030\026\031\ \n\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.105 Tw T* (\r\026\035\024\f\034 \023\030\024\r\036\007\036\027\017\036 \216\214\221\ \f)Tj /Span<>> BDC ( )Tj EMC (\222\210\212 \027\036 \n\036\027\036\036 52 \206\030, \f\024)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.403 Tw T* [(\023\031\021\f\021\r\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\ \023\017\036\005 \235\021\024\030\023\017\030\017\n\017\007\017\027\026\n\ \017)20( )]TJ -0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.765 0 Td [(\006\017\f\023\035\026\021\017\027\024\n )0.5(\017\035\017 )0.5(\n\017\021\024\n\017\006\017\027\024\n, )0.5(\r\022\035\033\004\036\027\017\036\n )0.5(\r\f\036\b)20.1( )]TJ 0.104 Tw -0.765 -1.218 Td (\027\036\024\002\b\024\007\017\n\t\b \f\021\030\031\022\021\031\030 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n \024\002\035\031\004\036\027\017\016 \f\024\020\035\026\ \f)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.277 Tw T* [(\027\024 \022\035\017\027\017\004\036\f\022\017\n \030\036\022\024\n\036\ \027\007\026\006\017\016\n [6,7]. \215\026\006\017\036\027\021\t)20( )]TJ 0.158 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\t\n \024\021\r\036\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\216\214\221, \026\030\036\020\017\f\021\030\017\030\024\r\026\027\027\t\ \n)20( )]TJ -0.006 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036 6 \n\036\f\016\006\036\r \023\024\f\035\036\ \023\024\f\035\036\007\027\036\020\024 \007\027\016 \035\031\004\036\r\024\ \005)20( )]TJ 0.341 Tw T* [(\021\036\030\026\023\017\017, \002\t\035\017 \022\035\026\f\f\017\235\017\ \006\017\030\024\r\026\027\t \022\026\022 \017\n\036\033\013\017\036)20( )]TJ 0.352 Tw T* (\027\036\023\024\035\027\t\005 \024\021\r\036\021. \215\026\006\017\036\027\ \021\t, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\024\020\030\036\f)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.152 Tw T* (\f\017\030\024\r\026\027\017\036 \002\t\035\024 \r\t\016\r\035\036\027\024\ \r)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\036\036 \023\024\007\027\017\005 \f\030\024\022,)20( )]TJ 0.359 Tw T* [(\002\t\035\017 \022\035\026\f\f\017\235\017\006\017\030\024\r\026\027\t \ \022\026\022 \017\n\036\033\013\017\036 \030\036\006\017\007\017\r)20( )]TJ -0.02 Tw T* (\026\002\024\035\036\r\026\027\017\016.)Tj 0 Tc 0.168 Tw T* (\215\024\f\035\036 \007\017\026\020\027\024\f\021\017\022\017 \030\036\006\ \017\007\017\r\026 \017\035\017 \027\036\023\024\035\027\024\020\024 \024\ \021\r\036\021\026 )Tj T* (\007\024\023\031\f\022\026\035\024\f\034 \027\026\004\026\035\024 \035\036\ \004\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017, \f\024\024\021)Tj 0 Tw (-)Tj T* (\r\036\021\f\021\r\031\033\013\026\016 \017\027\235\024\030\n\026\006\017\ \016 \r\027\024\f\017\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\007\017\235\017\022\026\021\024\030.)Tj 0.17 Tw T* (\025\030\017\021\036\030\017\016\n\017 \023\024\f\021\026\027\024\r\022\017\ \007\017\026\020\027\024\026 \027\036\023\024\035\027\024\020\024 \024\ \021\r\036\021\026 )Tj 0.02 Tw T* [(\017\035\017 )0.5(\030\036\006\017\007\017\r\026 \030\026\022\026 \026\027\026\035\034\027\ \024\020\024 )0.5(\022\026\027\026\035\026 )0.5(\002\t\035\017 )0.5(\n\024\030\235\024\035\024)]TJ 0 Tw (-)Tj -0.015 Tw T* (\020\017\004\036\f\022\026\016 \r\036\030\017\235\017\022\026\006\017\016\ \030\036\006\017\007\017\r\026/\023\030\024\007\024\035\032\036\027\027\ \024\020\024 \030\024)Tj 0 Tw (-)Tj 0.015 Tw T* (\f\021\026 \024\023\031\b\024\035\017 \017/\017\035\017 \030\024\f\021 \024\ \f\021\026\021\024\004\027\024\005 \024\023\031\b\024\035\017 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.26 Tw T* 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(\030\002\001\007\t\004\b\001\005\007\n)Tj /T1_2 1 Tf 0.155 Tw 0 -1.218 TD (\222\021\026\007\017\033 \024\023\031\b\024\035\017 \024\006\036\027\017\ \r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036)Tj 0 Tw (-)Tj 0.061 Tw 0 -1.218 TD (\n\024\005 \f\021\026\007\017\030\024\r\026\027\017\016 TNM \204\036\032\ \007\031\027\026\030\024\007\027\024\020\024 \024\002\255\036\007\017\027\ \036\027)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD (\027\024\020\024 \022\024\n\017\021\036\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\024\030\034\002\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\024\n \(UJCC\) \(8-\036 \017\007\026)Tj 0 Tw (-)Tj 0.006 Tw 0 -1.218 TD (\027\017\036\) \007\035\016 \030\026\022\026 \026\027\026\035\034\027\024\ \020\024 \022\026\027\026\035\026. \203\026\035\017\004\017\036 \023\024\ \030\026\032\036\027\017\016 )Tj 0.122 Tw T* (\030\036\020\017\024\027\026\030\027\t\b 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14 70.8661 678.3822 Tm [(Denis\022)-23.2(V)62(.\022)-23.3(Alek)11(santse)11.1(v)]TJ 8.162 0 0 8.162 185.4202 683.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 190.0562 678.3822 Tm [(, Marina\022)-23.2(V)62(.\022)-23.3(Ch)11(ernykh)]TJ 0 Tw 8.162 0 0 8.162 310.9283 683.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 315.5643 678.3822 Tm [(, Elena\022)-23.2(A)-31(.\022)-23.3(Romanov)10(a )]TJ 0 Tw 8.162 0 0 8.162 438.5131 683.0442 Tm (1)Tj 14 0 0 14 443.1491 678.3822 Tm (, )Tj -26.592 -1.143 Td [(Ev)10(geny\022)-23.3(G.\022)-23.2(R)20(ybak)11(ov)]TJ 8.162 0 0 8.162 181.3896 667.0442 Tm (2)Tj 0.023 Tw 14 0 0 14 186.0255 662.3822 Tm [(, Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(Ne)11(v)10(olskikh)]TJ 0 Tw 8.162 0 0 8.162 319.0492 667.0442 Tm (3)Tj 0.023 Tw 14 0 0 14 323.6852 662.3822 Tm [(, Violet)-19.9(ta\022)-23.3(A)-31(.\022)-23.3(A)20(v)10(deenk)11.1(o)]TJ 0 Tw 8.162 0 0 8.162 451.5294 667.0442 Tm (3)Tj 14 0 0 14 456.1653 662.3822 Tm (, )Tj -27.521 -1.143 Td [(Sultanat\022)-23.2(S.\022)-23.3(P)10(er)31(egor)20(odie)11(v)10(a)]TJ 8.162 0 0 8.162 215.8987 651.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 220.5346 646.3822 Tm [(, Z)21(aman\022)-23.2(Z.\022)-23.3(Mammedli)]TJ 0 Tw 8.162 0 0 8.162 345.3691 651.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 350.005 646.3822 Tm [(, Ser)31(gey\022)-23.2(S.\022)-23.3(Gor)31(dee)11(v)]TJ 0 Tw 8.162 0 0 8.162 464.2421 651.0442 Tm [(1)69(,4,5)]TJ 5.83 0 0 5.83 70.8661 632.043 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 628.713 Tm [(N.N.\022)-23.3(Blokhin National Medical Resear)31(ch Center of\022)-23.3(Oncology of\022)-23.3(th)11(e Ministr)-31(y of\022)-23.2(Health of\022)-23.3(th)10.9(e Russia \(K)41(ashir)20.1(sk)11(oje )]TJ -0.331 -1.2 Td [(Sh)11(osse, 2)69(4, Moscow)22(, 1)212(1)113(5)23(5)35(22, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 608.043 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 604.713 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 596.043 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 592.713 Tm [(A)-31(.F)94(.\022)-23.3(T)40(s)10(yba Medical Radiological Resear)31(ch Center is a\022)-23.2(br)21(anch of\022)-23.3(th)11(e F)20(eder)21(al State Budgetar)-31(y Institution \232NMIC )]TJ -0.331 -1.2 Td [(of\022)-23.3(Radiology\233 of\022)-23.3(th)11(e Ministr)-30.9(y of\022)-23.2(Health of\022)-23.2(th)11(e Russian F)19.9(eder)21.1(ation \(K)41(or)20(ole)11(v)10(a\022)-23.3(st., 4, Obninsk, 2)69(49036, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 572.0431 Tm (4)Tj 0.023 Tw 10 0 0 10 74.1775 568.7131 Tm [(T)20(y)10(umen State Medical Univ)12.1(er)20(sit)-20(y of\022)-23.3(th)11(e Ministr)-30.9(y of\022)-23.3(Health of\022)-23.3(th)11(e Russian F)20(eder)21(ation \(Odesskay)21.1(a\022)-23.3(st., 5)23(4, T)20(y)10(umen, )]TJ -0.331 -1.2 Td [(6)35(2)23(5023, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 548.0432 Tm (5)Tj 0.023 Tw 10 0 0 10 74.1775 544.7131 Tm [(T)30(h)11(e Sech)11(enov Fir)20(st Moscow State Medical Univ)12(er)20(sit)-19.9(y of\022)-23.3(th)11(e Ministr)-31(y of\022)-23.2(Health of\022)-23.3(th)11(e Russian F)20(eder)21(ation )]TJ -0.331 -1.2 Td [(\(T)20(r)10(ubetskay)21.1(a\022)-23.3(st., 8, bld.\022)-23.3(2, Moscow)22(, 8)113(1)212(1)138(90)25(48, Russia\))]TJ /T1_1 1 Tf 0.009 Tw 9 0 0 9 119.0551 514.2092 Tm [(AIM: )0.6(to )0.5(ev)16(aluate )0.6(the )0.5(oncological )0.6(and )0.5(surgical )0.6(results )0.6(of )0.5(the )0.5(treatment )0.6(in )0.6(patients )0.5(with )0.5(recur)-16(rent )0.5(sq)14(uamous )0.5(cell )0.5(anal )]TJ 0.023 Tw 0 -1.111 TD [(carcinoma \(SC)-18(A)26(C\) af)-45.9(ter CRT and to identify p)46(rognostic factors of ov)13(erall sur)-41.9(viv)16(al \(OS\).)]TJ 0.153 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: patients who under)-32(w)12(ent abdominoper)-36.9(ineal resection \(AP)66(R\) betw)12.1(een Januar)-43(y 2013 to )]TJ 0.018 Tw T* [(December 2024 for persistent or )0.5(recur)-16(rent sq)14(uamous cell carcinoma )0.5(of the anal canal af)-46(ter CRT w)12(ere retrospectiv)13(ely )]TJ 0.103 Tw T* [(analysed )0.6(in )0.5(a )0.6(sing)13(le-centre )0.6(study)32(. )0.5(The )0.6(early )0.5(and )0.6(long-ter)-14(m )0.6(outcomes, )0.6(recur)-16(rence )0.5(and )0.5(incom)16(plete )0.5(response )0.5(to )0.6(CRT )]TJ -0.009 Tw T* [(w)12(ere com)16(pared. The p)46(r)-37(imar)-42.9(y endpoint w)13(as ov)13(erall sur)-41.9(viv)16(al \(OS\). Additionally)42(, the disease-free sur)-42(viv)15.9(al \(DFS\), the R0 )]TJ 0.023 Tw T* [(resection rate, post-op com)16(plications, r)-37(isk factors, second recur)-15.9(rence af)-45.9(ter AP)66(R w)12(ere ev)15.9(aluated.)]TJ T* [(RESUL)30(T)-10(S: sixty)-14(-one patients under)-31.9(w)12(ent AP)66(R, of which 34 \(55.7%\) had a recur)-16(rence and 27 \(44.3%\) had an incom)]TJ 0 Tw (-)Tj 0.12 Tw 0 -1.111 TD [(plete response to CRT)63(. The median follow-up )0.5(w)13(as 35.9 months \(95% CI: 25.3\23146.6\). The ov)12.9(erall 3-year sur)-42(viv)16(al )]TJ 0.016 Tw 0 -1.111 TD [(rate w)13(as 66.5% )0.5(\(95% CI 54.0\23181.9%\). )0.5(The 3-year OS )0.5(w)12.9(as )0.5(74.0% for relapses \(95% CI 59.3\23193.0%\) and 56.4% for )]TJ 0.009 Tw T* [(incom)16(plete response to CRT \(95% CI 37.9\23184.0%\). The dif)-39.9(ferences in OS w)12(ere unreliable \(HR 1.8; 95% CI: 0.7\2314.6; )]TJ 0.079 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.2\). The 3-year DFS w)13(as 55.4% \(95% CI 43.2\23171.1%\). Three-year DFS w)13(as 63.1% \(95%CI 47.4\23183.7%\) for )]TJ 0.052 Tw T* [(relapses )0.5(and )0.5(46.1% \(95% )0.5(CI 29.2\23172.5%\) )0.5(for )0.5(incom)16(plete )0.5(response )0.5(to )0.5(CRT)63(. Dif)-40(ferences in )0.5(DFS )0.5(w)11.9(ere unreliable \(HR )]TJ 0.148 Tw T* [(1.70; 95% CI: 0.7\2314,5%; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.18\). T)54(en \(16.1%\) patients )0.5(dev)13(eloped )0.5(distant metastases af)-46(ter surg)12(er)-43(y)32(. Sixteen )]TJ 0.119 Tw T* [(\(47.1%\) patients dev)13(eloped local recur)-16(rence af)-46(ter AP)66(R, 2 \(12.5%\) of them under)-31.9(w)12(ent salv)16(ag)12(e re-operation and )]TJ 0.091 Tw T* [(ano)13(ther tw)12(o of them \(12.5%\) under)-31.9(w)12(ent repeated radiation therap)12(y)32(. Sev)13(en \(43.7%\) out of 16 patients receiv)13(ed )]TJ -0.004 Tw T* [(palliativ)13.1(e chemo)13(therap)12(y)32(. The remaining 5/16 \(31.3%\) patients receiv)13.1(ed sym)16(p)13(tomatic treatment. The median ag)12(e of )]TJ 0.027 Tw 0 -1.111 TD [(patients with recur)-16(rent relapse w)13(as 23.9 \(95% CI 23.7\23124.1\) months. R0 resection w)12.9(as per)-34(for)-14(med in 55 \(90.30%\) )]TJ 0.028 Tw 0 -1.111 TD [(patients. OS w)13(as signif)-42.9(icantly reduced by incom)16(plete response of the p)46(r)-37(imar)-43(y tumor to CRT \(HR 2.7; 95% CI: 0.98\231)]TJ 0.023 Tw T* (7.92; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.05\) and violation of the CRT regimen \(HR 2.8; 95% CI: 1.03\2317.62; \ \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.04\).)Tj 0.048 Tw T* [(C)21(ON)22(CLUSION: )0.6(surgical )0.5(treatment )0.6(of )0.5(recur)-15.9(rent )0.5(SC)-18(A)26(C )0.5(is )0.5(associated )0.6(with )0.5(a )0.5(high )0.5(r)-36.9(isk )0.5(of )0.5(second )0.5(recur)-16(rence, )0.5(but )0.5(remains )]TJ -0.02 Tw T* [(the only po)13(tentially curativ)13(e op)13(tion for this categor)-42.9(y of patients. It is necessar)-43(y to f)-43(ind w)13(ays to im)16(p)46(rov)13(e local disease )]TJ 0.023 Tw T* [(control dur)-37(ing surgical treatment.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.906 278.94 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( abdominoper)-36.9(ineal resection, sq)14(uamous cell carcinoma of)]TJ /Span<>> BDC ( )Tj EMC [(the anal canal, recur)-15.9(rences)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.028 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.037 Tw 6.472 0 Td [( A)-11.7(l)-23.7(e)-16.1(k)-39.6(s)-24.7(a)-7.6(n)-17.3(t)-48.8(s)-22.9(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)40.6(V)39.7(.)-23.5(, C)-15.9(h)-15.1(e)-12.1(r)-35.9(n)-14.9(y)-21.9(k)-16.8(h)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)40.6(V)39.7(.)-23.5(, R)-2.5(o)-9.2(m)-8.3(a)-7.6(n)-11.8(o)-10.4(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)-23.9(A)-23(.)-23.5(, R)-30.3(y)-19.6(b)-17.7(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)15(G)-11.5(.)-23.5(, N)-14.6(e)-15.8(v)-15.4(o)-15.6(l)-53.2(s)-11.1(k)-41.1(i)-6.6(k)-16.8(h)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.8(A)-23(.)-23.5(, A)7.6(v)-16.8(d)-15.3(e)-25.2(e)-11.5(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-23(.)-23.5(, P)-4.2(e)-12.1(r)-19.1(e)-20.9(g)-10.3(o)-11.7(r)-15.8(o)-20.5(d)-15.8(i)-11(e)-15.8(v)-28.3(a)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-26.9(S)-9.6(.)-23.5(,)23( )]TJ 0.005 Tc -0.035 Tw -6.477 -1.2 Td [(M)-8.1(a)-9(m)-5.6(m)-16(e)-20.4(d)-10.7(l)-16.1(i)]TJ /Span<>> BDC ( )Tj EMC [(Z)-22.3(.)-28(Z)-22.3(.)-22.9(, G)-13.6(o)-11.2(r)-17.5(d)-14.7(e)-24.6(e)-15.2(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9(.)-26.3(S)-9(. S)-11.5(u)-7(r)-16.1(g)-28.3(i)-4.4(c)-20.9(a)-10.8(l t)-30.2(r)-18.5(e)-12.4(a)-17.6(t)-25.5(m)-16(e)-11(n)-16.7(t f)-24.6(o)-11.2(r p)-19.4(a)-17.6(t)-45.6(i)-10.4(e)-10.9(n)-16.8(t)-48.3(s w)-45.1(i)-15.2(t)-25.5(h p)-24.1(e)-11.5(r)-29.7(s)-25.5(i)-6.8(s)-28.7(t)-24.1(e)-11(n)-16.7(t a)-7(n)-14(d r)-18.5(e)-18.5(c)-11.5(u)-7.1(r)-39.9(r)-18.5(e)-10.9(n)-16.7(t s)-18.9(q)-15.4(u)-5.9(a)-9.1(m)-11.8(o)-12.7(u)-21.3(s c)-9.2(e)-17.4(l)-27.8(l a)-7(n)-7.2(a)-10.9(l c)-20.9(a)-9.6(r)-11.2(c)-37.6(i)-2.6(n)-11.3(o)-8.6(m)-7.7(a)-13.1(. )]TJ /T1_1 1 Tf 0.011 Tc -0.011 Tw [(K)10.5(o)-3.5(lo)-3.5(p)-1(rok)-22.6(t)-1.2(o)-3.5(lo)-6.7(g)-16.7(i)3.3(a)2.4(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)11.6(9)-22.6(\226)11.7(2)5.1(7)80.1(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.8(-)9.8(2)-8.9(0)-3.9(2)4.2(6)-26.7(-)9.8(2)-1.5(5)-23.5(-)55.1(1)26.9(-)55.1(1)11.7(9)-23.7(-)9.8(2)5(7)]TJ /T1_2 1 Tf 0.01 Tc -0.002 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.003 Tw 10.537 0 Td ( \003\f\027\n\024\020\025\006\027\021 \220.\211., \214\216\221\210 \253\001\ \215\002\037 \031\025\n\031\f\031\b\022\022 \022\026. \001.\001.)Tj /Span<>> BDC ( )Tj EMC (\221\f\031\200\022\025\020\273 \215\022\025\016\030\032\020\021\020 \206\ \031\024\024\022\022, \202\020\213\022\032\024\n\031\027 \213\031\024\024\ \027, \030.)Tj /Span<>> BDC ( )Tj EMC (24, \215\031\024\n\021\020, )Tj 0.023 Tw -10.542 -1.2 Td (115522, \206\031\024\024\022\t; e-mail: alexancev@gmail.com)Tj /T1_2 1 Tf 0.01 Tc 0 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.6(F)13(OR)4.9( )0.6(C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.005 Tw 14.014 0 Td [( )0.5(Alek)-22.9(santsev )0.5(D.V)61(., )0.6(N)28(.N)28(.)]TJ /Span<>> BDC ( )Tj EMC 9.006 0 Td [(Blokhin )0.6(N)18(ational )0.5(Medical )0.5(R)21(esearch )0.6(Center )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 17.426 0 Td [(Oncology)42.1(, )0.5(K)17(ashirsk)13(oje )0.6(Shosse, )0.5(24, )0.5(Moscow)52.1(, )]TJ 0.023 Tw -40.45 -1.2 Td [(115522, R)22(ussia; e-mail: ale)-15(x)10(ancev@gmail.com)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 18.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 522.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 513.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.1026 56.0378 Tm (20)Tj ET endstream endobj 1689 0 obj [1693 0 R] endobj 1690 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\205\n\005\002\005\013\n\225\004\016\r)10(\025\004 \020\004\225\004\t\n\004 \224\017\n\004\t\026)11(\025\b \016\022\005\004\n\202\n\b\025\024 )]TJ 0 -1 TD [(\224\020\025\016\r)10(\025\r)-9.9(\020\004\026)11(\025\225\t\025\013)10(\025 \005\017\r\017 \017\t\017\020\200\t\025\013)10(\025 \r\017\t\017\020\017)]TJ 41.019 1 Td [(Sur)31(gical tr)31(eatment for patients with per)20.1(sistent and )]TJ 3.771 -1 Td [(r)31(ecurr)31.1(ent s)11(quamous cell anal car)31.1(cinoma)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 136.0105 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 136.0105 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 98.8026 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 98.8026 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-19-27)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 79.7861 695.3259 Tm [(\205\n\005\002\005\013\n\225\004\016\r)10.1(\025\004 \020\004\225\004\t\n\004 \224\017\n\004\t\026)11.1(\025\b \016\022)-23.3(\005\004\n\202\n\b\025\024 )]TJ 1.189 -1.105 Td [(\224\020\025\016\r)10(\025\r)-9.9(\020\004\026)11(\025\225\t\025\013)10(\025 \005\017\r\017 \017\t\017\020\200\t\025\013)10.1(\025 \r\017\t\017\020\017)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\f)-21(\020\004\r\016\017\t\004\b\022)-23.2(\201.\021.)]TJ 8.162 0 0 8.162 138.8002 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 143.4362 649.822 Tm [(, \215\004\005\t\217\220\022)-23.2(\235.\021.)]TJ 0 Tw 8.162 0 0 8.162 226.0709 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 230.7069 649.822 Tm [(, \033\025\024\017\t\025\b\017\022)-23.2(\240.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 323.6599 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 328.2958 649.822 Tm [(, \033\217\255\017\r)10(\025\b\022)-23.2(\240.\031)72(.)]TJ 0 Tw 8.162 0 0 8.162 408.3271 654.484 Tm (2)Tj 14 0 0 14 412.9631 649.822 Tm (, )Tj -26.46 -1.143 Td [(\007\004\b\025\020\200\016\r\n\220\022)-23.2(\f)-31(.\f)-31(.)]TJ 8.162 0 0 8.162 140.186 638.484 Tm (3)Tj 0.023 Tw 14 0 0 14 144.822 633.822 Tm [(, \f\b\202\004\004\t\r)10.1(\025\022)-23.3(\021.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 236.5705 638.484 Tm (3)Tj 0.023 Tw 14 0 0 14 241.2065 633.822 Tm [(, \034\004\005\004\013)10(\025\005\025\202\n\004\b\017\022)-23.2(\001.\001.)]TJ 0 Tw 8.162 0 0 8.162 368.3054 638.484 Tm (1)Tj 0.023 Tw 14 0 0 14 372.9413 633.822 Tm [(, \235\017\024\004\202)-21(\020\n\022)-23.2(\203.\203.)]TJ 0 Tw 8.162 0 0 8.162 462.6461 638.484 Tm (1)Tj 14 0 0 14 467.2821 633.822 Tm (, )Tj -30.34 -1.143 Td [(\031)80(\025\005\202\004\004\b\022)-23.3(\001.\001.)]TJ 8.162 0 0 8.162 116.7232 622.484 Tm [(1)69(,4,5)]TJ 5.83 0 0 5.83 42.5197 603.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 600.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \025\t\r)10(\025\020\025\013\n\n \n\024.\022)-23.3(\007.\007.\022)-23.3(\006\020\025\220\n\t\017\273 \235\n\t\212\202\005\017\b\017 \033\025\016\ \016\n\n \(\037)41(\017\204\n\005\016\r)10(\025\004 \204., \202.\022)-23.3(2)69(4, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)113(5)23(5)35(22, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\016\016\n\213\))Tj ( )Tj 5.83 0 0 5.83 42.5197 579.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 576.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 555.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 552.1528 Tm [(\235\033\007\003 \n\024.\022)-23.2(\f)-31(.\210.\022)-23.3(\003\217\255\017\022)-23.2(\230 \216\n\020\n\017\020\017 \210\031\006)42(\227\253\007\235\030\003 \005\017\202\n\025\020\025\013\n\n\273 \235\n\t\ \212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020.\022)-23.3(\037)31(\025\005\025\020\004\b\017, \202.\022)-23.3(4, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\036\255\t\n\t\016\r, 2)69(49036, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 531.4828 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 528.1528 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\032)41(\206\024\004\t\016\r\n\221 \031)52(\235)21(\227\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n, \032)41(\206\024\004\t\200 \(\002\020.\022)-23.1(\036\202\004\016\016\r\017\213, \202.\022)-23.1(5)23(4, \013)62(.\022)-23.1(\032)41(\206\024\004\t\200, 6)35(2)23(5023, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 519.4829 Tm (5)Tj 0.023 Tw 10 0 0 10 45.8311 516.1529 Tm [(\210\031)83(\f\036)20(\227 \021\036 \034\004\005\b\217\221 \235\031)52(\235)21(\227 \n\024.\022)-23.3(\030.\235.\022)-23.3(\001\004\225\004\t\025\b\017 \235\n\t\212\202\005\017\b\017 \033\025\016\ \016\n\n \(\002\020.\022)-23.3(\032)30(\005\002\255\004\r\017\213, \202 8, \016)-10(\026\005)-31(.\022)-23.2(2, \013)62(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(8)113(1)212(1)138(90)25(48, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf -0.006 Tw 9 0 0 9 90.7087 485.649 Tm (\225\022\032\r\032\b\022\007\027\024\n\031\027 \f\027\007\027\025\022\027\ \t\021\f\t\027\023\024\t \027\030\022\025\024\023\021\027\025\025\031\235\ \033\031\023\027\025\006\022\020\f\017\025\031 \022\016\f\027\007\022\021\ \020\005\212\027\235 \031\033\006\022\027\235 \030\f\t \033\020\006\022\027\ \025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\032\027\006\022)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\030\022\021\020\026\022 \033\f\031\024\n\031\n\f\027\023\031\007\025\031\ \b\031 \032\020\n\020 \020\025\020\f\017\025\031\b\031 \n\020\025\020\f\020\ \(\004\206\003\202\) \033\031\024\f\027 \200\022\026\022\031\f\r\007\027\ \021\031\235 \023\027\032\020\033\022\022 \(\225\035\).)Tj -0.002 Tw T* (\037\036\035\034 \002\205\205\035\036\220\217\211\003\001\002\226: \031\006\ \027\025\022\023\017 \031\025\n\031\f\031\b\022\007\027\024\n\022\027 \022\ )Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\022\027 \032\027\016\r\f\017\023\020\ \023\013 \f\027\007\027\025\022\t \032\027\006\022\030\022\021\031\021 \004\ \206\003\202 \033\031\024\f\027 )Tj 0.023 Tw T* (\225\035 \022)Tj /Span<>> BDC ( )Tj EMC (\021\013\t\021\f\027\025\022\027 \033\032\031\b\025\031\024\023\022\007\027\ \024\n\022\200 \203\020\n\023\031\032\031\021 \031\240\212\027\235 \021\013\ \255\022\021\020\027\026\031\024\023\022 \(\217\211\).)Tj T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\006\027\025\023\032\031\021\031\026 \022\024\024\f\027\030\ \031\021\020\025\022\022 \032\027\023\032\031\024\033\027\n\023\022\021\025\ \031 \240\013\f\022 \033\032\031\020\025\020\f\022\016\022\032\031\021\020\ \025\013 \032\027\016\r\f\017\023\020)Tj 0 Tw (-)Tj 0.095 Tw 0 -1.111 TD (\023\013 \f\027\007\027\025\022\t \033\020\006\022\027\025\023\031\021, \ \033\027\032\027\025\027\024\213\022\200 \240\032\005\213\025\031-\033\032\ \031\026\027\255\025\031\024\023\025\r\005 \204\n\024\023\022\032\033\020\ \006\022\005 \033\032\t\026\031\235 \n\022\213\n\022 \(\221\004\230\) \021\ )Tj /Span<>> BDC ( )Tj EMC (\033\027\032\022\031\030 )Tj 0.132 Tw 0 -1.111 TD (\024)Tj /Span<>> BDC ( )Tj EMC (\t\025\021\020\032\t 2013 \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\027\n\020\240\032\017 2024 \b\b. \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r \033\027\032\024\022\024\023\022\032\r\005\212\027\ \b\031 \022\f\022 \032\027\006\022\030\022\021\025\031\b\031 \033\f\031\024\ \n\031\n\f\027\023\031\007\025\031\b\031 \032\020\n\020 )Tj 0.096 Tw T* (\020\025\020\f\017\025\031\b\031 \n\020\025\020\f\020 \033\031\024\f\027\ \225\035. \205\032\020\021\025\022\021\020\f\022 \032\020\025\025\022\027\ \022)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\020\f\027\025\025\013\027 \032\027\016\r\f\017\023\020\023\013\ \f\027\007\027\025\022\t \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\032\027\006\022)Tj 0 Tw (-)Tj 0.091 Tw T* (\030\022\021\031\026 \016\020\240\031\f\027\021\020\025\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\025\027\033\031\f\025\013\026 \031\023\021\027\023\031\026 \025\020)Tj /Span<>> BDC ( )Tj EMC (\225\035. \217\024\025\031\021\025\013\026 \031\006\027\025\022\021\020\ \027\026\013\026 \033\020\032\020\026\027\023\032\031\026 \240\013\f\020\ \031\240\212\020\t \021\013\255\022)Tj 0 Tw (-)Tj 0.024 Tw T* (\021\020\027\026\031\024\023\017 \(\217\211\). \220\031\033\031\f\025\022\ \023\027\f\017\025\031 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 \032\027\006\022\030\022\021\031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\025\027\033\031\f\025\031\b\031 \031\023\021\027\023\020 \025\020)Tj /Span<>> BDC ( )Tj EMC (\225\035 \031\006\027\025\022\021\020\f\022 \021\013\255\022\021\020\027\ \026\031\024\023\017 )Tj 0.166 Tw T* (\240\027\016 \033\032\031\b\032\027\024\024\022\032\031\021\020\025\022\t\ \(\211\221\004\), \007\020\024\023\031\023\r R0 \032\027\016\027\n\006\022\ \235, \031\024\f\031\255\025\027\025\022\235 \200\022\032\r\032\b\022\007\ \027\024\n\031\b\031 \f\027\007\027\025\022\t, \203\020\n\023\031\032\013\ \032\022\024\n\020 )Tj 0.023 Tw T* (\033\031\021\023\031\032\025\031\b\031 \032\027\006\022\030\022\021\020 \ \033\031\024\f\027 \221\004\230.)Tj 0.152 Tw T* [(\206\036\207\210\035\034\003\201: )0.6(\213\027\024\023\022\030\027\024\t\023\022 )0.7(\031\030\025\031\026\r )0.6(\(n)]TJ /Span<>> BDC ( )Tj EMC 16.675 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.884 0 Td [(61\) )0.6(\033\020\006\022\027\025\023\r )0.6(\021\013\033\031\f\025\027\025\020 )0.6(\240\032\005\213\025\031-\033\032\031\026\027\255\025\031\024\023\025\020\ \t )0.5(\204\n\024\023\022\032\033\020\006\022\t, )]TJ 0.147 Tw -17.559 -1.111 Td (\022\016)Tj /Span<>> BDC ( )Tj EMC (\025\022\200 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r \032\027\006\022\030\022\021\020)Tj /Span<>> BDC ( )Tj EMC 11.915 0 Td (\227 34 \(55,7%\), \033\031)Tj /Span<>> BDC ( )Tj EMC [(\033\031\021\031\030\r \025\027\033\031\f\025\031\b\031 )0.5(\031\023\021\027\023\020 \025\020)]TJ /Span<>> BDC ( )Tj EMC (\225\035)Tj /Span<>> BDC ( )Tj EMC (\227 27 \(44,3%\). \215\027\030\022\020\025\020 )Tj 0.274 Tw -11.915 -1.111 Td [(\025\020\240\f\005\030\027\025\022\t )0.5(\024\031\024\023\020\021\022\f\020 )0.5(35,9 \(95% \220\002: 25,3\23146,6\) \026\027\024\t\006\027\021. )0.5(\217\240\212\020\t )0.5(3-\f\027\023\025\t\t \021\013\255\022\021\020\027\026\031\024\023\017 \024\ \031\024\023\020\021\022\f\020 )]TJ -0.027 Tw T* (66,50% \(95% \220\002 54,00\23181,90%\). \032\027\200\f\027\023\025\t\t\ \031\240\212\020\t \021\013\255\022\021\020\027\026\031\024\023\017 \(\217\ \211\) \024\031\024\023\020\021\022\f\020 \030\f\t \032\027\006\022\030\022\ \021\031\021)Tj /Span<>> BDC ( )Tj EMC (\227 74,30% )Tj 0.196 Tw T* (\(95% \220\002 59,31\23193,04%\) \022)Tj /Span<>> BDC ( )Tj EMC (\030\f\t \025\027\033\031\f\025\031\b\031 \031\023\021\027\023\020 \025\020\ )Tj /Span<>> BDC ( )Tj EMC (\225\035)Tj /Span<>> BDC ( )Tj EMC (\227 56,40% \(95% \220\002 37,90\23184,00%\). \206\020\016\f\022\007\022\ \t )Tj 0.096 Tw T* (\021)Tj /Span<>> BDC ( )Tj EMC (\031\240\212\027\235 \021\013\255\022\021\020\027\026\031\024\023\022 \240\ \013\f\022 \025\027\030\031\024\023\031\021\027\032\025\013 \(HR1,80; 95\ % \220\002: 0,70\2314,60; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,20\). \032\027\200\f\027\023\025\t\t \021\013\255\022\021\020\027)Tj 0 Tw (-)Tj 0.056 Tw T* (\026\031\024\023\017 \240\027\016 \033\032\031\b\032\027\024\024\022\032\ \031\021\020\025\022\t \(\211\221\004\) \024\031\024\023\020\021\022\f\020\ 55,40% \(95% \220\002 43,20\23171,10%\). \032\027\200\f\027\023\025\t\t\ \211\221\004 \024\031\024\023\020\021\022\f\020 )Tj 0.076 Tw T* (63,10% \(95% \220\002 47,37\23183,74%\) \030\f\t \032\027\006\022\030\022\ \021\031\021 \022)Tj /Span<>> BDC ( )Tj EMC (46,1% \(95% \220\002 29,20\23172,50%\))Tj /Span<>> BDC ( )Tj EMC (\227 \030\f\t \025\027\033\031\f\025\031\b\031 \031\023\021\027\023\020 \ )Tj 0.058 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC 1.273 0 Td [(\225\035. )0.5(\206\020\016\f\022\007\022\t \021)]TJ /Span<>> BDC ( )Tj EMC 6.928 0 Td [(\021\013\255\022\021\020\027\026\031\024\023\022 )0.5(\240\027\016 )0.5(\033\032\031\b\032\027\024\024\022\032\031\021\020\025\022\t )0.6(\240\013\f\022 )0.5(\025\027\030\031\024\023\031\021\027\032\025\013 \(HR )0.5(1,70; )0.5(95% \220\002: 0,69\2314,48; )]TJ 0.01 Tw -8.2 -1.111 Td (\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\). \210)Tj /Span<>> BDC ( )Tj EMC (10/61)Tj /Span<>> BDC ( )Tj EMC [(\(16,4%\) \033\020\006\022\027\025\023\031\021 \032\020\016\021\022\f\022\ \024\017 )0.5(\026\027\023\020\024\023\020\016\013 \033\031\024\f\027 \200\022\032\r\032\ \b\022\007\027\024\n\031\b\031 \f\027\007\027\025\022\t. \210)]TJ /Span<>> BDC ( )Tj EMC (16/34 \(47,1%\) )Tj 0.029 Tw T* (\033\020\006\022\027\025\023\031\021 \032\020\016\021\022\f\024\t \033\031\ \021\023\031\032\025\013\235 \032\027\006\022\030\022\021 \033\031\024\f\ \027 \221\004\230, \022\016)Tj /Span<>> BDC ( )Tj EMC (\n\031\023\031\032\013\200 2/16 \(12,5%\) \033\027\032\027\025\027\024\f\ \022 \033\031\021\023\031\032\025\r\005 \031\033\027\032\020)Tj 0 Tw (-)Tj 0.002 Tw 0 -1.111 TD (\006\022\005 \022)Tj /Span<>> BDC ( )Tj EMC (2/16 \(5,8%\) \021\013\033\031\f\025\027\025\020 \033\031\021\023\031\032\ \025\020\t \f\r\007\027\021\020\t \023\027\032\020\033\022\t, 7/16 \(43,\ 8%\) \033\031\f\r\007\022\f\022 \033\020\f\f\022\020\023\022\021\025\r\005\ \200\022\026\022\031\023\027)Tj 0 Tw (-)Tj 0.103 Tw 0 -1.111 TD (\032\020\033\022\005, \031\024\023\020\f\017\025\013\026 5/16 \(31,3%\) \ \033\020\006\022\027\025\023\020\026 \031\n\020\016\020\025\031 \024\022\ \026\033\023\031\026\020\023\022\007\027\024\n\031\027 \f\027\007\027\025\ \022\027. \215\027\030\022\020\025\020 \217\211 \033\020\006\022\027\025\ \023\031\021 )Tj -0.027 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\023\031\032\025\013\026 \032\027\006\022\030\022\021\031\026\ \024\031\024\023\020\021\022\f\020 23,9 \(95% \220\002: 23,7\23124,1\) \ \026\027\024\t\006\027\021. R0 \032\027\016\027\n\006\022\t \021\013\033\ \031\f\025\027\025\020 55/61 \(90,2%\) )Tj 0.066 Tw T* (\033\020\006\022\027\025\023\020\026. \205\023\020\023\022\024\023\022\007\ \027\024\n\022 \016\025\020\007\022\026\031 \024\025\022\255\020\f\022 \031\ \240\212\r\005 \021\013\255\022\021\020\027\026\031\024\023\017, \025\027\ \033\031\f\025\013\235 \031\023\021\027\023 \033\027\032\021\022\007\025\ \031\235 \031\033\r\200\031\f\022 )Tj 0.006 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC (\225\035 \(HR 2,70; 95% \220\002: 0,98\2317,92; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05\), \025\020\032\r\213\027\025\022\027 \032\027\255\022\026\020 \225\ \035 \(HR 2,80; 95% \220\002: 1,03\2317,62; \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\).)Tj 0.213 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.5(\200\022\032\r\032\b\022\007\027\024\n\031\027 \f\027\007\027\025\022\027\ )0.5(\032\027\006\022\030\022\021\031\021 )0.5(\004\206\003\202 \024\021\t\016\020\025\031 \024)]TJ /Span<>> BDC ( )Tj EMC [(\021\013\024\031\n\022\026 \032\022\024\n\031\026 )0.5(\033\031\021\023\031\032\025\031\b\031 \032\027\006\022\030\022\021\020,\ )]TJ 0.133 Tw T* (\031\030\025\020\n\031 \031\024\023\020\233\023\024\t \027\030\022\025\024\ \023\021\027\025\025\031\235 \033\031\023\027\025\006\022\020\f\017\025\031\ \022\016\f\027\007\022\021\020\005\212\027\235 \031\033\006\022\027\235\ \030\f\t \030\020\025\025\031\235 \n\020\023\027\b\031\032\022\022 \033\ \020\006\022\027\025\023\031\021. )Tj 0.01 Tc 0.271 Tw T* (\001\027\031\240\200\031\030\022\026 \033\031\022\024\n \033\r\023\027\235\ \r\024\022\f\027\025\022\t \f\031\n\020\f\017\025\031\b\031 \n\031\025\023\ \032\031\f\t \016\020\240\031\f\027\021\020\025\022\t \033\032\022)Tj /Span<>> BDC ( )Tj EMC [(\033\032\031\021\027\030\027\025\022\022 \200\022\032\r\032\b\022\007\027\ \024\n\031\b\031)10( )]TJ -0.01 Tw T* (\f\027\007\027\025\022\t.)Tj /T1_2 1 Tf 0.018 Tw 8 0 0 8 42.5596 160.3797 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \240\032\005\213\025\031-\033\032\031\026\027\255\025\031\024\023\025\020\ \t \204\n\024\023\022\032\033\020\006\022\t, \033\f\031\024\n\031\n\f\027\ \023\031\007\025\013\235 \032\020\n \020\025\020\f\017\025\031\b\031 \n\020\ \025\020\f\020, \032\027\006\022\030\022\021\013)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.024 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5.3( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.014 Tc -0.035 Tw 8.979 0 Td ( \202\035\036\022\f\026\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \232\036\030\027\t\b)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \217\024\n\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\206., \203\036\r\024\035\034\f\022\017\b)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \202\r\007\036\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \215\036\030\036\020\024\030\024\007\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC [(\222.\222.,)14.1( )]TJ 0.005 Tc -8.984 -1.2 Td [(\204\026)0.5(\n\036\007\035)0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\003.)0.5(\003.,)0.5( \206\024\030\007)0.5(\036\036\r)]TJ /Span<>> BDC 9.179 0 Td ( )Tj EMC [(\222.\222)0.5(. \216\017)0.5(\030\031\030\020)0.5(\017\004\036)0.5(\f\022\024\036)0.5( \035\036\004)0.5(\036\027\017)0.5(\036 \023\026\006)0.5(\017\036\027)0.5(\021\024\r)0.5( \f)]TJ /Span<>> BDC 16.967 0 Td ( )Tj EMC [(\030\036\006)0.5(\017\007\017)0.5(\r\024\n \023)0.5(\035\024\f\022)0.5(\024\022\035)0.5(\036\021\024\004)0.5(\027\024\020)0.5(\024 \030\026\022)0.5(\026 \026\027\026)0.5(\035\034\027)0.5(\024\020\024)0.5( \022)0.5(\026\027\026)0.5(\035\026.)0.5( )]TJ /T1_1 1 Tf -0.005 Tw [(\202)0.5(\031\f\031)0.5(\033\032\031)0.5(\n\023\031)0.5(\f\031\b)0.5(\022\t.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 30.547 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (19\22627. https://doi.org/10.33878/2073-7556-2026-25-1-19-27)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 494.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 47.6607 485.226 Tm (\021\033\r\035\f\033)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5895 837.3533 Tm [(\004\n\006\202\006\t\037)-20(\b\230\t\233\207)5( \017)-32(\r)41(\037)31(\r\230\006)]TJ /T1_0 1 Tf 0 -1.605 TD [(ORIGINAL)5( ARTICLES)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.002 56.0378 Tm (19)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 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1.296 0 Td (Gao)Tj /Span<>> BDC ( )Tj EMC [(XH, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (J, Zhao)Tj /Span<>> BDC ( )Tj EMC [(ZY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and gene)-11.9(t)-32(ic r)-36.9(isk f)16(a)-17(c)-16(t)17.1(or)-10(s for )]TJ 0.205 Tw -1.296 -1.25 Td [(F)20(anconi anemia )0.5(in juvenile )0.5(pol)35(yposis p)32(a)15(t)-32(ients. )]TJ /T1_2 1 Tf 20.024 0 Td (BMC Gastroenterol)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw -20.024 -1.25 Td [(2020;20\(1\):167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12876-020-01238-7)Tj 0 0 0 1 k /GS1 gs 0.301 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)11(osner)]TJ /Span<>> BDC ( )Tj EMC (G, Bannon)Tj /Span<>> BDC ( )Tj EMC [(SA, M)-24(or)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)15(denoma)15.1(t)17(ous P)10(ol)35(yposis )]TJ 0.019 Tc 0.675 Tw -1.296 -1.25 Td [(Pheno)17.4(t)-9.7(ype in BMPR1A and SMAD4 V)25.4(ar)-36.6(iant Car)-23.6(r)-36.6(ier)-9.6(s. )]TJ /T1_2 1 Tf -0.019 Tw [(Clin)19( )]TJ 0.022 Tc 0.801 Tw T* [(T)55.8(ransl Gastroenterol)]TJ /T1_1 1 Tf [(. 2022;13\(10\):e00527. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.022 Tw (10.14309/)Tj 0 Tc 0 Tw T* [(c)-16(tg.0000000000000527)]TJ 0 0 0 1 k /GS1 gs -0.007 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(V)25(asen)]TJ /Span<>> BDC ( )Tj EMC 2.538 0 Td [(HF)24(A, )0.6(T)45(oml)-31(inson)]TJ /Span<>> BDC ( )Tj EMC 6.336 0 Td [(I, )0.6(Castells)]TJ /Span<>> BDC ( )Tj EMC 4.055 0 Td [(A. )0.6(Cl)-31(inical )0.6(mana)-17(gement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.769 0 Td [(her)-24(ed)]TJ 0 Tw (-)Tj 0.23 Tw -24.994 -1.25 Td [(i)-24(t)15(ar)-23.9(y col)30(or)-24(ec)-16(t)15.1(al cancer syndr)-31.9(omes. )]TJ /T1_2 1 Tf [(N)18(at R)21.1(ev Gastroenterol Hepatol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2015;12\(2\):88\22697. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1038/nr)-32(gastr)-31.9(o.2014.229)]TJ 0 0 0 1 k /GS1 gs 0.08 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)15(t)17(of)-56(fel)]TJ /Span<>> BDC ( )Tj EMC [(EM, K)-16(astr)-36.9(inos)]TJ /Span<>> BDC ( )Tj EMC [(F. F)20(amil)-31(ial Col)30(or)-23.9(ec)-16(t)15(al Cancer, Be)-11(yond L)70(ynch )]TJ 0.013 Tc -0.013 Tw -1.296 -1.25 Td [(Syndr)-32.1(ome. )]TJ /T1_2 1 Tf 0.485 Tw 5.107 0 Td [(Clin )0.6(Gastroenterol )0.5(Hepatol)]TJ /T1_1 1 Tf [(. )0.5(2014;12\(7\):1059\2261068.)13( )]TJ 0 Tc 0 Tw -5.107 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.cgh.2013.08.015)Tj 0 0 0 1 k /GS1 gs 0.02 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ma)-17(car)-32(on)]TJ /Span<>> BDC ( )Tj EMC [(C, Bur)-24(k)10(e)]TJ /Span<>> BDC ( )Tj EMC [(C)19.9(A. Her)-23.9(edi)-24(t)15(ar)-24(y col)30(or)-24(ec)-16(t)15.1(al cancer syndr)-32(omes and )]TJ 0.083 Tw -1.296 -1.25 Td [(gene)-12(t)-32(ic )0.5(test)-32(ing. )]TJ /T1_2 1 Tf (J Surg Oncol)Tj /T1_1 1 Tf [(. 2015;111\(1\):103\226111. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/)Tj T* (jso.23772)Tj 0 0 0 1 k /GS1 gs 0.131 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Br)-33(and\343o)]TJ /Span<>> BDC ( )Tj EMC [(C, L)-32(a)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(P, F)-19(igueir)-23.9(ed)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(P)40(a)15(t)-32(ients )]TJ -0.036 Tw -1.296 -1.25 Td [(wi)-24(t)-13(h Her)-24(edi)-24(t)15(ar)-23.9(y Col)30(or)-24(ec)-16(t)15.1(al Cancer Syndr)-31.9(omes. )]TJ /T1_2 1 Tf [(GE P)15(or)-39.9(t J Gastroenterol. )]TJ /T1_1 1 Tf 0.023 Tw T* [(2015;22\(5\):204\226212. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jpge.2015.06.002)Tj 0 0 0 1 k /GS1 gs 0.08 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Al)-31(imi)]TJ /Span<>> BDC ( )Tj EMC [(A, W)22(ee)-12(t)-12.9(h-F)10(einstein)]TJ /Span<>> BDC ( )Tj EMC [(L)-35(A, Anglesio)]TJ /Span<>> BDC ( )Tj EMC [(MS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. O)-24(ver)-29.9(l)-16(ap of)]TJ /Span<>> BDC ( )Tj EMC (juve)Tj 0 Tw (-)Tj 0.031 Tw -1.296 -1.25 Td [(nile pol)35(yposis syndr)-32(ome and Co)-14(w)14(den syndr)-32(ome due t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(de novo chr)-32(o)]TJ 0 Tw (-)Tj 0.136 Tw T* [(mosome 10 dele)-12(t)-32(ion invol)30(v)-16(ing BMPR1A and PTEN: im)10(pl)-31(ica)15(t)-32(ions for )]TJ 0.04 Tw T* [(tr)-24(ea)15(tment )0.6(and sur)-31.9(veill)-16(ance. )]TJ /T1_2 1 Tf 11.476 0 Td [(Am )0.5(J )0.5(Med )0.5(Genet)]TJ /Span<>> BDC ( )Tj EMC 6.598 0 Td (A.)Tj /T1_1 1 Tf [( )0.5(2015;167A\(6\):1305\226)]TJ 0.023 Tw -18.074 -1.25 Td [(1308. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ajmg.a.36977)Tj 0 0 0 1 k /GS1 gs 0.06 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Br)-24(eckpo)17(t)]TJ /Span<>> BDC ( )Tj EMC [(J, T)47(hien)11(pont)]TJ /Span<>> BDC ( )Tj EMC [(B, Bauter)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. BMPR1A is a)Tj /Span<>> BDC ( )Tj EMC [(candid)42(a)15.1(te )]TJ 0.262 Tw -1.296 -1.25 Td [(gene for congeni)-24(t)15(al hear)-22(t defec)-16(ts asso)-16(c)-24(ia)15(ted wi)-24(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ecur)-24(r)-24(ent )]TJ 0.135 Tw T* [(10q22q23 dele)-12(t)-32(ion syndr)-32(ome. )]TJ /T1_2 1 Tf (Eur J Med Genet)Tj /T1_1 1 Tf (. 2012;55\(1\):12\22616. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/j.ejmg.2011.08.004)Tj 0 0 0 1 k /GS1 gs 0.034 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dahd)42(aleh)]TJ /Span<>> BDC ( )Tj EMC [(FS, Car)-24(r)]TJ /Span<>> BDC ( )Tj EMC [(JC, Cal)30(v)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-11.9(t al. Juvenile pol)35(yposis and o)17(t)-13(her )]TJ 0.088 Tw -1.796 -1.25 Td [(intest)-32(inal pol)35(yposis syndr)-32(omes wi)-24(t)-13(h micr)-32(odele)-12(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(chr)-31.9(omosome )]TJ 0 Tw T* (10q22-23. )Tj /T1_2 1 Tf 0.282 Tw 4.644 0 Td (Clin Genet)Tj /T1_1 1 Tf [(. 2012;81\(2\):110\226116. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1399-)Tj -4.644 -1.25 Td (0004.2011.01767.x)Tj 0 0 0 1 k /GS1 gs 0.167 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ar)-24(e)-11.9(tz)]TJ /Span<>> BDC ( )Tj EMC [(S, S)15(t)-32(ienen)]TJ /Span<>> BDC ( )Tj EMC (D, Uhlhaas)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. High p)25(r)-32(opor)-22(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ar)-31.9(ge )]TJ 0.186 Tw -1.796 -1.25 Td [(genomic S)-21(T)30(K11 dele)-12(t)-31.9(ions in P)30.1(eutz-Jegher)-9.9(s syndr)-31.9(ome. )]TJ /T1_2 1 Tf (Hum Mutat)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2005;26\(6\):513\226519. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/humu.20253)Tj 0 0 0 1 k /GS1 gs 0.011 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(v)-15(an )0.5(Ha)15(t)-30(tem)]TJ /Span<>> BDC ( )Tj EMC 4.909 0 Td [(W)31(A, Br)-31.9(osens)]TJ /Span<>> BDC ( )Tj EMC [(L)-34.9(AA, de )0.5(L)35(eng)]TJ /Span<>> BDC ( )Tj EMC 10.421 0 Td [(WW)31(J, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(ar)-32(ge )0.5(genomic )]TJ 0.167 Tw -17.126 -1.25 Td [(dele)-12(t)-32(ions )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(SMAD4, BMPR1A )0.5(and PTEN in )0.5(juvenile )0.5(pol)35(yposis. )]TJ /T1_2 1 Tf 0 Tw (Gut)Tj /T1_1 1 Tf (. )Tj 0.023 Tw 29.055 50 Td [(2008;57\(5\):623\226627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/gut.2007.142927)Tj 0 0 0 1 k /GS1 gs 0.15 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cohen)Tj /Span<>> BDC ( )Tj EMC [(S, Y)30.1(er)-22(ushalmy-F)10(eler)]TJ /Span<>> BDC ( )Tj EMC [(A, R)11(ojas)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Juvenile pol)35(yposis )]TJ 0.073 Tw -1.796 -1.25 Td [(syndr)-32(ome in childr)-23.9(en: T)46.9(he)]TJ /Span<>> BDC ( )Tj EMC [(im)10(p)32(a)-17(c)-15.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(SMAD4 and BMPR1A mut)15.1(a)15(t)-32(ions )]TJ 0 Tw T* [(on cl)-31(inical pheno)17(t)-9.9(ype and pol)35(yp bur)-24(den. )]TJ /T1_2 1 Tf [(J P)15(ediatr Gastroenterol N)21(utr)]TJ /T1_1 1 Tf (. )Tj 0.023 Tw T* [(2024;79\(1\):161\226167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/jpn3.12257)Tj 0 0 0 1 k /GS1 gs 0.086 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ho)-14(we)]TJ /Span<>> BDC ( )Tj EMC [(JR, Sa)15(yed)]TJ /Span<>> BDC ( )Tj EMC (MG, Ahmed)Tj /Span<>> BDC ( )Tj EMC [(AF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(ev)-14.9(alence of)]TJ /Span<>> BDC ( )Tj EMC (MADH4 )Tj 0.047 Tw -1.796 -1.25 Td [(and BMPR1A mut)15(a)15(t)-32(ions in juvenile pol)35(yposis and absence of)]TJ /Span<>> BDC ( )Tj EMC (BMPR2, )Tj 0.125 Tw T* [(BMPR1B, and A)16(CVR1 mut)15(a)15(t)-32(ions. )]TJ /T1_2 1 Tf (J Med Genet)Tj /T1_1 1 Tf (. 2004;41\(7\):484\226491. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/jmg.2004.018598)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.561 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.857 0 Td [(Cal)29.7(v)-15.3(a-Cer)-32.3(queir)-33.3(a)]TJ /Span<>> BDC ( )Tj EMC [(D, Chinna)14.6(t)-13.3(hambi)]TJ /Span<>> BDC ( )Tj EMC [(S, P)29.6(echman)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)15( )]TJ 0.001 Tc 0.349 Tw -1.857 -1.25 Td [(T)47.5(he)]TJ /Span<>> BDC 1.402 0 Td ( )Tj EMC [(r)-32.5(a)15.4(t)0.5(e o)0.5(f)]TJ /Span<>> BDC 3.599 0 Td ( )Tj EMC [(ge)0.5(r)-15.5(ml)-30.5(i)0.5(n)0.5(e m)0.5(ut)15.5(a)15.5(t)-31.6(i)0.5(on)0.5(s)0.5( an)0.5(d l)-15.5(a)0.5(r)-31.6(g)0.5(e d)0.5(e)0.5(le)-11.5(t)-31.5(io)0.5(ns)0.5( o)0.5(f)]TJ /Span<>> BDC ( )Tj EMC [(S)0.5(MA)0.5(D)0.5(4)1( )]TJ 0 Tc 0.212 Tw -5.001 -1.25 Td [(and BMPR1A in juvenile pol)35(yposis. )]TJ /T1_2 1 Tf (Clin Genet.)Tj /T1_1 1 Tf ( 2009;75\(1\):79\22685. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1399-0004.2008.01091.x)Tj 0 0 0 1 k /GS1 gs 0.258 Tw -1.847 -1.25 Td (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)-17(cF)20(ar)-30(l)-16(and)]TJ /Span<>> BDC ( )Tj EMC [(SP, Ebr)-32.9(ahimzadeh)]TJ /Span<>> BDC ( )Tj EMC [(JE, Z)30(elle)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Pheno)17(t)-10(ypic )]TJ 0.171 Tw -1.796 -1.25 Td [(dif)-56(fer)-23.9(ences in juvenile pol)35(yposis syndr)-31.9(ome wi)-24(t)-13(h or wi)-23.9(t)-13(hout a)]TJ /Span<>> BDC ( )Tj EMC (dis)Tj 0 Tw (-)Tj 0.009 Tc 0.349 Tw T* [(ease-causing SMAD4/BMPR1A v)-14.8(ar)-36.7(iant. )]TJ /T1_2 1 Tf [(Cancer Prev R)21.2(es \(Phila\).)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;14\(2\):215\226222. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1158/1940-6207.C)20(APR-20-0348)]TJ 0 0 0 1 k /GS1 gs 0.034 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jelsig)Tj /Span<>> BDC ( )Tj EMC [(AM, v)-15(an O)-24(ver)-23.9(eem Hansen)]TJ /Span<>> BDC ( )Tj EMC (T, Gede)Tj /Span<>> BDC ( )Tj EMC [(LB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Whole genome )Tj 0.111 Tw -1.796 -1.25 Td [(sequenc)-23.9(ing and disease p)32(a)15(t)-30(ter)-15(n in p)32(a)15(t)-32(ients wi)-24(t)-13(h juvenile pol)35(yposis )]TJ 0.229 Tw T* [(syndr)-32(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(na)15(t)-32(ionwide stud)17(y)]TJ /T1_2 1 Tf [(. F)15(am Cancer)]TJ /T1_1 1 Tf (. 2023;22\(4\):429\226436. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10689-023-00338-z)Tj 0 0 0 1 k /GS1 gs 0.016 Tc 0.593 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.861 0 Td (\231\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \230\n\016\027\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\203., \025\031\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\230., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)16( )]TJ 0 Tc 0.284 Tw -1.861 -1.25 Td (\025\035\017\027\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\007\ \026\006\017\017. \202\007\036\027\024\n\026\021\024\027\t\005 \023\024\ \035\017\023\024\027\t\005 \f\017\027\007)Tj 0 Tw (-)Tj 0.015 Tc -0.015 Tw T* (\030\024\n. )Tj /T1_2 1 Tf 2.71 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_1 1 Tf 0.534 Tw 7.665 0 Td [(. 2022;2\(21\):10\22624. / S)-15.6(hel)35.4(ygin)]TJ /Span<>> BDC ( )Tj EMC [(Y.A.,)15( )]TJ 0 Tc 0.098 Tw -10.375 -1.25 Td [(Imy)22(ani)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(E.N., K)25(utsev)]TJ /Span<>> BDC ( )Tj EMC [(S.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical guidel)-30.9(ines. A)15(denoma)15(t)17(ous )]TJ 0.023 Tw T* [(pol)35(yposis syndr)-31.9(ome )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.023 Tw (. 2022;21\(2\):10\22624. \(in Russ.\).)Tj 0.211 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\024\002\024\036\r\026)Tj /Span<>> BDC ( )Tj EMC 3.814 0 Td [(\204.\216., )0.5(\231\036\035\t\020\017\027)]TJ /Span<>> BDC ( )Tj EMC 6.585 0 Td [(\224.\202., )0.5(\205\030\024\035\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.103 0 Td [(\222.\202., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.203 0 Td (\f\024\026\r\021. )Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 2.998 0 Td [(MUT)-54(YH)]TJ /T1_1 1 Tf 0 Tc 0 Tw 2.786 0 Td (-)Tj 0.012 Tc 0.457 Tw -27.286 -1.25 Td (\026\f\f\024\006\017\017\030\024\r\026\027\027\t\005 \023\024\035\017\023\ \024 \021\024\035\f\021\024\005 \022\017\001\022\017. )Tj /T1_2 1 Tf -0.012 Tw [(\027\032\020\033\027\021\023\022\007\027\024\n\022\235)12.1( )]TJ 0 Tc 0 Tw T* (\020\032\200\022\021.)Tj /T1_1 1 Tf 0.132 Tw [( 2019;91\(2\):97\226100. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.26442/00403660.2019.02.0001)Tj T* (24)Tj 0 0 0 1 k /GS1 gs -0.022 Tw [( )0.5(/ )0.5(T)45(oboev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M.H., )0.6(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC 11.288 0 Td [(Y.A., )0.5(F)10(r)-32(ol)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.A., )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 8.948 0 Td [(MUT)-54(YH)]TJ /T1_1 1 Tf 0 Tc 0 Tw 2.786 0 Td [(-asso)-16(c)-24(ia)15.1(ted )]TJ 0.022 Tw -23.022 -1.25 Td [(pol)35(yposis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(on. )]TJ /T1_2 1 Tf [(T)54(er Arkh.)]TJ /T1_1 1 Tf [( 2019;91\(2\):97\226100. \(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw T* (10.26442/00403660.2019.02.000124)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.559 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.857 0 Td (\037\031\022\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\222., \231\031\002\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\215., \025\031\034\n\017\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)15( )]TJ 0 Tc 0.337 Tw -1.857 -1.25 Td (\212\017\235\235\036\030\036\027\006\017\026\035\034\027\t\005 \007\017\026\ \020\027\024 )Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw 12.871 0 Td [(MUT)-54(YH)]TJ /T1_1 1 Tf 0 Tc 0.337 Tw 2.786 0 Td (-\026\f\f\024\006\017\017\030\024\r\026\027\027\024\020\024 \023\024\035\ \017\023\024)Tj 0 Tw (-)Tj 0.331 Tw -15.657 -1.25 Td (\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\030\026\007\017\004\036\f\022\017\b \023\024\035\017\023\024\r\ \021\024\035\f\021\024\005 \022\017\001\022\017. )Tj /T1_2 1 Tf (\206\031\024\024\022\235\024\n\022\235 \255\r\032)Tj 0 Tw (-)Tj 0.023 Tc 0.831 Tw T* [(\025\020\f )0.5(\b\020\024\023\032\031\204\025\023\027\032\031\f\031\b\022\022, )0.5(\b\027\033\020\023\031\f\031\b\022\022, )0.5(\n\031\f\031\033\032\031\n\023\031\f\031\b\022\022)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.005 Tc 0.35 Tw T* [(2018;28\(6\):51\22657. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.22416/1382-4376-2018-28-6-51-57)Tj 0 0 0 1 k /GS1 gs 0 Tc -0.233 Tw [( )-587.7(/ )]TJ 0.1 Tw T* [(T)60(suk)-17(anov)]TJ /Span<>> BDC ( )Tj EMC [(A.S., S)-16(hubin)]TJ /Span<>> BDC ( )Tj EMC [(V.P., K)25(uzminov)]TJ /Span<>> BDC ( )Tj EMC [(A.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dif)-56(fer)-23.9(ent)-32(ial dia)-16.9(g)]TJ 0 Tw (-)Tj 0.009 Tw T* (nosis of)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.01 Tc -0.01 Tw 3.379 0 Td [(MUT)-54(YH)]TJ /T1_1 1 Tf 0 Tc 0.009 Tw 2.786 0 Td [(-asso)-16(c)-23.9(ia)15(ted pol)35(yposis and spor)-32.9(adic col)30(on pol)35(yps. )]TJ /T1_2 1 Tf 0 Tw [(R)22(uss )]TJ 0.202 Tw -6.165 -1.25 Td [(J Gastroenterol Hepatol Colop)46(roctol. )]TJ /T1_1 1 Tf (2018;28\(6\):51\22657. \(in Russ.\). )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.22416/1382-4376-2018-28-6-51-57)Tj /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\001\032)50(\f)42(\032\214\027 \007\036)30.1(\235\240\033)30(\f)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 27.2901 56.0378 Tm 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(\020\036\027\024\n\036 \004\036\035\024\r\036\022\026 HGMD )Tj 0.141 Tw 0 -1.218 TD [(P)35(r)-32(ofessional )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.124 0 Td [(\n\017\030\036, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 3.964 0 Td [(\007\026\027\027\t\005 )0.6(\n\024\n\036\027\021 )0.5(\024\023\017\f\026\027\024 )0.5(\002\024)]TJ 0 Tw (-)Tj 0.052 Tw -10.088 -1.218 Td (\035\036\036 160 \023\026\021\024\020\036\027\027\t\b/\r\036\030\024\016\ \021\027\024 \023\026\021\024\020\036\027\027\t\b \r\026\030\017\026\027\ \021\024\r )Tj 0.053 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_2 1 Tf 0 Tw (SMAD4)Tj /T1_1 1 Tf 0.053 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 180)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_2 1 Tf 0 Tw [(BMP)66(R1A. )]TJ /T1_1 1 Tf 0.053 Tw 19.054 0 Td (\221\026\022 \022\026\022 )Tj 0.301 Tw -19.054 -1.218 Td (\004\026\f\021\024\021\026 \r\t\016\r\035\016\036\n\t\b \023\026\021\024\ \020\036\027\027\t\b \r\026\030\017\026\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.053 Tw T* (\035\017\004\027\t\b \020\036\027\026\b \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\222\224\215 \027\036 \023\030\036\r\t\001\026\036\021 87%, )Tj -0.013 Tw T* (\027\036\035\034\016 \017\f\022\035\033\004\017\021\034 \027\026\035\017\ \004\017\036 \007\030\031\020\017\b \020\036\027\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\027\t)Tj 0 Tw (-)Tj 0.265 Tw T* (\n\017/\r\036\030\024\016\021\027\024 \023\026\021\024\020\036\027\027\t\ \n\017 \r\026\030\017\026\027\021\026\n\017, \024\021\r\036\021\f\021\r\036\ \027)Tj 0 Tw (-)Tj T* (\027\t\b \026)Tj /Span<>> BDC ( )Tj EMC (C\224\215.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 310.7779 Tm (\023\233\023\037\230\233)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.35 Tw 10 0 0 10 42.5197 286.4219 Tm [(\200\t\f\024\022\026\016 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)0.5(\r\t\f\024\022\024\023\030\024\017\r\024\007\017)]TJ 0 Tw (-)Tj 0.234 Tw -6.91 -1.218 Td [(\021\036\035\034\027\024\020\024 )0.5(\f\036\022\r\036\027\017\030\024\r\026\027\017\016; )0.6(\002\024\035\034\027\t\n )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 16.651 0 Td [(\027\026\035\017\004\017\036\n )0.6(20 )]TJ 0.335 Tw -16.651 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \026\007\036\027\024\n\026\021\024\027\t\b \027\024\ \r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005\ )Tj 0.098 Tw T* [(\022\017\001\022\017, )0.5(\027\024 \f)]TJ /Span<>> BDC ( )Tj EMC 5.252 0 Td [(\024\021\f\031\021\f\021\r\017\036\n )0.6(\023\026\021\024\020\036\027\027\t\b/\r\036\030\024\016\021\027\024 )0.6(\023\026\021\024)]TJ 0 Tw (-)Tj 0.079 Tw -5.252 -1.218 Td (\020\036\027\027\t\b \r\026\030\017\026\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj /T1_2 1 Tf 0 Tw (APC)Tj /T1_1 1 Tf 0.079 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.01 Tc -0.01 Tw 13.816 0 Td [(MUT)-54(YH)]TJ /T1_1 1 Tf 0 Tc 0 Tw 2.786 0 Td (,)Tj /T1_2 1 Tf ( )Tj /T1_1 1 Tf 0.497 0 Td (\027\036\024\002\b\024\007\017\n\024 )Tj -17.098 -1.218 Td (\r\t\023\024\035\027\016\021\034 \023\024\035\027\024\220\022\024\n\027\ \024\036 \f\036\022\r\036\027\017\030\024\r\026\027\017\036.)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.335 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-5.9(\017)-5.5(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026)]TJ /Span<>> BDC (\005)Tj EMC 8.66 0 Td [(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.004 Tc 0.339 Tw [( \037)-34.3(\r)4.8(\n)8.8(\020\025\031)5.6(\021)]TJ /Span<>> BDC 11.16 0 Td ( )Tj EMC [(\003)-6.3(.)39.7(\205)-6.1(.)3.9(,)-4( )]TJ 0 Tc 0 Tw -19.82 -1.218 Td [(\221)5(\020)1.8(\032)6.4(\022)7.2(\025)3.8(\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, \211)12.5(\f)9.1(\020\024)4(\n)9.8(\031)]TJ /Span<>> BDC ( )Tj EMC [()65(.)7.3(\003)-2.3(.)]TJ /T1_1 1 Tf 0.644 Tw 23.244 36.534 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.9(\021)-9.8(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_2 1 Tf -0.029 Tc 0.673 Tw [( \035)-17.3(\031)-23.1(\b)-19(\022)-21.8(\025)-25.2(\031)-19.4(\021)-26.9(\020)]TJ /Span<>> BDC 19.39 0 Td ( )Tj EMC [(\003)-31.3(.\001.)-21.2(,)-29( )]TJ 0 Tc 0 Tw -19.39 -1.218 Td [(\211)12.5(\f)9(\020\024)4(\n)9.8(\031)]TJ /Span<>> BDC ( )Tj EMC [()65.1(.)7.3(\003)-2.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \211)12.5(\f)9(\020\024)4(\n)9.9(\031)]TJ /Span<>> BDC ( )Tj EMC [()65(.)7.3(\003)-2.3(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.923 Tw [( \221)5(\020)1.8(\032)6.5(\022)7.2(\025)3.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 12.838 0 Td [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, )0.5(\037)-30.3(\r)8.8(\n)12.7(\020)4.3(\025)3.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 7.551 0 Td [(\003)-2.3(.)43.7(\205)-2.1(.)7.8(, )]TJ -0.002 Tc 0.002 Tw -20.388 -1.218 Td [(\004)6.8(\031)3.3(\025)1.8(\031\026)5(\020\032)-1.9(\027\025)8.7(\n)7.8(\031)]TJ /Span<>> BDC 5.387 0 Td ( )Tj EMC [(\003)-4.3(.)5.3(\003)-4.3(.)]TJ /T1_4 1 Tf 0 Tc 0.023 Tw -5.387 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.135 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf -0.002 Tc 0.137 Tw [( A)1.6(l)2.8(e)-30.6(xe)-4.5(y)]TJ /Span<>> BDC 16.913 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 1.125 0 Td ( )Tj EMC [(T)49(s)9.2(u)2.6(k)13.8(a)-2.8(no)-2.6(v)31.6(,)-2( )]TJ 0 Tc 0 Tw -18.039 -1.218 Td [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(ar)-35.3(i)8.4(n)1.9(o)-0.6(v , T)49.8(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)0.8(l)3.3(a)-3(s)9.1(k)12.9(o)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(A)3.8(n)5.2(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-5.5(o)-4.4(g)-14.5(i)8.4(n)1.9(o)-0.6(v)10.8(a)-14(, T)49.8(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(V)0.8(l)3.3(a)-3(s)9.1(k)12.9(o)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_2 1 Tf [( T)49.7(a)-4.9(t)-30(y)3.8(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)0.7(l)3.3(a)-3(s)9.1(k)12.9(o)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.654 Tw 3.238 0 Td [( A)3.6(l)4.8(e)-28.6(x)2.2(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(ar)-35.3(i)8.5(n)1.9(o)-0.6(v)33.6(, A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(T)50.9(s)11.2(u)4.6(k)15.8(a)-0.8(n)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw -3.238 -1.218 Td [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(on)1.9(om)4.3(ar)2.4(e)-2.5(n)7.5(k)12.9(o)]TJ /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\200\035\026\f\022\024 \221.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-4533-6555)Tj T* (\214\024\020\017\027\024\r\026 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-7248-111X)Tj T* (\207\026\030\017\027\024\r \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-1443-960X)Tj T* (\037\031\022\026\027\024\r \202.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-8571-7462)Tj T* (\215\024\027\024\n\026\030\036\027\022\024 \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-7203-1859)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(T)40(a)15(t)-10(y)22(ana A. Vl)-15.9(asko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4533-6555)Tj T* [(Anna N. L)35.1(o)-16(ginov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7248-111X)Tj T* [(Ale)-18(x)12(e)-10.9(y A. Bar)-36.9(inov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1443-960X)Tj T* [(Ale)-18(x)12(e)-10.9(y S. T)60(suk)-17(anov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8571-7462)Tj T* [(Ale)-18(x)12(e)-10.9(y A. P)10(onomar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7203-1859)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\020\023\031\b\027\025\025\013\027 \021\020\032\022\020\025\023\013\ \b\027\025\031\021 SMAD \022)Tj /Span<>> BDC ( )Tj EMC (BMPR1A \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\005\021\027\025\022\f\017\025\013\026 \033\031\f\022\033\031\016\031\026\ [10,13-15])Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( P)25.9(a)-9.2(t)-10.6(h)-2.4(o)-8.6(g)-6.7(e)-7(n)1.7(i)-1.8(c v)6.3(a)-4.2(r)-39(i)1.5(a)-5(n)-0.7(t)-32.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(S)13.9(M)5.3(A)10(D a)-5(n)-4.8(d B)5.3(M)8(P)22.6(R)16.3(1)15.3(A g)-6.8(e)-7(n)-2.4(e)-22(s i)3.9(n p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s w)-26.7(i)-3.4(t)-10.6(h j)2.4(u)-6.3(v)2.3(e)-7(n)1.7(i)2.9(le p)-9.1(o)-5.3(l)6.6(y)-11(p)-9.1(o)-1.1(s)-12.5(i)6.6(s [)76.6(1)42.1(0)-6(,)24.5(1)26.3(3)-4.9(-)47.3(1)37.6(5)59.4(])]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 127.8091 715.181 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 195.8406 715.181 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 229.8563 715.181 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 360.25 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 428.2815 715.181 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 127.8091 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 195.8406 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 229.8563 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 360 703.7117 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 360.25 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 428.2815 703.7117 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 692.2426 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 127.8091 692.2426 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 156.1555 692.2426 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 195.8406 692.2426 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 692.2426 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 360.25 692.2426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 428.2815 692.2426 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 661.8312 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 661.5812 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 127.8091 661.5812 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 156.1555 661.5812 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 195.8406 661.5812 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 661.5812 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 360.25 661.5812 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 428.2815 661.5812 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 631.17 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 630.92 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.8091 630.92 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 156.1555 630.92 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 195.8406 630.92 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 229.8563 630.92 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 360.25 630.92 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 630.92 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 610.1087 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 609.8587 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 127.8091 609.8587 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 156.1555 609.8587 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 195.8406 609.8587 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 609.8587 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 360.25 609.8587 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 428.2815 609.8587 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 579.4474 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 579.1974 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 127.8091 579.1974 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 156.1555 579.1974 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 195.8406 579.1974 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 579.1974 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 360.25 579.1974 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 428.2815 579.1974 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 548.7861 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 548.5361 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 127.8091 548.5361 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 156.1555 548.5361 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 195.8406 548.5361 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 229.8563 548.5361 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 360.25 548.5361 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 428.2815 548.5361 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 508.5248 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 508.2748 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 127.8091 508.2748 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 127.8091 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 156.1555 508.2748 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 156.1555 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 195.8406 508.2748 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 195.8406 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 229.8563 508.2748 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 229.8563 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 360.25 508.2748 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 360.25 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 428.2815 508.2748 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 428.2815 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 468.2635 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 468.0135 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 127.8091 468.0135 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 156.1555 468.0135 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 195.8406 468.0135 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 229.8563 468.0135 cm 0 0 m 130.394 0 l S Q q 1 0 0 1 360.25 468.0135 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 428.2815 468.0135 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 75.0455 700.8117 Tm (\032\003\002\006)Tj 7.603 0 Td (\027\002\240)Tj 3.549 0 Td (\255\003\006\004\b\004)Tj 4.741 0.6 Td (\255\r\214\001\t )Tj 0.63 -1.2 Td (\()Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf (\))Tj 3.271 1.2 Td (\030\004\217\003\002\003\004 \212\004\003\002\n\r\b\b\013\216 \004\006\t\ \004\b\003\002 \(%\) )Tj 6.284 -1.2 Td (/ \n\r\b\013 )Tj 10.147 1.317 Td (\030\t\217\f\002 \212\004\003\002\n\r\b\b\013\216 \004\006\t\004\b\003\002\  / \n\r\b\013)Tj 1.579 -1.434 Td (\020\002\201\220\002\013\r)Tj -0.034 Tw 6.705 0 Td (\021\006\210\212\b\013\r \240\r\f\r\204\t\t)Tj /T1_1 1 Tf 0 Tw -48.189 -1.433 Td (S. Aretz [11])Tj 11.047 0 Td (2007)Tj 3.283 0 Td (\206\036\030\n\026\027\017\016)Tj 6.076 0 Td (80)Tj 8.188 0 Td (39/65)Tj /Span<>> BDC ( )Tj EMC (\(60%\))Tj -1.462 -1.2 Td (23/39)Tj /Span<>> BDC ( )Tj EMC (\(59%\) )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.284 -1.2 Td (16/39)Tj /Span<>> BDC ( )Tj EMC (\(41%\) )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 14.773 2.4 Td (17 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.284 -1.2 Td (13 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 9.038 1.2 Td (6 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.284 -1.2 Td (3 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf -50.091 -2.633 Td (W.A. Van Hattem [12])Tj 11.047 0 Td (2008)Tj 4.333 0 Td (\222\231\202)Tj 5.025 0 Td (27)Tj 8.188 0 Td (13/27)Tj /Span<>> BDC ( )Tj EMC (\(48%\))Tj -1.554 -1.2 Td (7/13)Tj /Span<>> BDC ( )Tj EMC (\(53,8%\) )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -1.502 -1.2 Td (6/13)Tj /Span<>> BDC ( )Tj EMC (\(46,2%\) )Tj /T1_2 1 Tf (BMPR1A/PTEN)Tj /T1_1 1 Tf 16.05 2.4 Td (4 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 0.284 -1.2 Td (7 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf 7.001 1.2 Td (2 )Tj /T1_2 1 Tf (BMPR1A/PTEN)Tj /T1_1 1 Tf -48.872 -3.833 Td (S. Cohen [13])Tj 11.047 0 Td (2024)Tj 3.527 0 Td (\230\030\026\017\035\034)Tj 5.582 0 Td (124)Tj 3.68 0 Td (55/124)Tj /Span<>> BDC ( )Tj EMC (\(44%\) 29/55)Tj /Span<>> BDC ( )Tj EMC (\(52,7%\) )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf ( )Tj 2.67 -1.2 Td (26/55)Tj /Span<>> BDC ( )Tj EMC (\(47,3%\) )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 16.8 1.2 Td (\226)Tj 8.504 0 Td (\226)Tj -51.809 -2.633 Td (J. Howe [14])Tj 11.047 0 Td (2004)Tj 4.333 0 Td (\222\231\202)Tj 5.025 0 Td (77)Tj 8.188 0 Td (30/77)Tj /Span<>> BDC ( )Tj EMC (\(39%\))Tj -1.609 -1.2 Td (14/30)Tj /Span<>> BDC ( )Tj EMC (\(46,7%\) )Tj /T1_2 1 Tf (MADH)Tj /T1_1 1 Tf -0.479 -1.2 Td (16/30)Tj /Span<>> BDC ( )Tj EMC (\(53,3%\) )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 16.8 2.4 Td (\226)Tj 8.504 0 Td (\226)Tj -51.809 -3.833 Td (D. Calva-Cerqueira [15])Tj 11.047 0 Td (2008)Tj 3.364 0 Td (\222\017\027\020\026\023\031\030)Tj 5.745 0 Td (102)Tj 8.188 0 Td (42/102)Tj /Span<>> BDC ( )Tj EMC (\(41%\))Tj -1.554 -1.2 Td (20/42)Tj /Span<>> BDC ( )Tj EMC (\(47,5%\) )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.284 -1.2 Td (22/42)Tj /Span<>> BDC ( )Tj EMC (\(52,5%\) )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 15.116 2.4 Td (10 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.284 -1.2 Td (15 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 8.788 1.2 Td (10 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.034 -1.2 Td (7 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf -50.091 -2.633 Td (S.P. MacFarland [16])Tj 11.047 0 Td (2021)Tj 4.333 0 Td (\222\231\202)Tj 4.775 0 Td (118)Tj 8.188 0 Td (54/118)Tj /Span<>> BDC ( )Tj EMC (\(46%\))Tj -1.587 -1.2 Td (27/54)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC /T1_1 1 Tf (\(50%\))Tj /T1_2 1 Tf ( SMAD4 )Tj /T1_1 1 Tf (\017)Tj -0.251 -1.2 Td (24/54)Tj /Span<>> BDC ( )Tj EMC (\(44,4%\))Tj /T1_2 1 Tf ( BMPR1A)Tj /T1_1 1 Tf -0.718 -1.2 Td (3/54)Tj /Span<>> BDC ( )Tj EMC (\(5,6%\) )Tj /T1_2 1 Tf (BMPR1A/PTEN)Tj /T1_1 1 Tf 15.55 3.6 Td (24 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 0.284 -1.2 Td (27 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf 7.251 1.2 Td (3 )Tj /T1_2 1 Tf (BMPR1A/PTEN)Tj /T1_1 1 Tf -48.872 -5.033 Td (A.M. Jelsig [17])Tj 11.047 0 Td (2023)Tj 3.972 0 Td (\212\026\027\017\016)Tj 5.386 0 Td (32)Tj 8.188 0 Td (27/32)Tj /Span<>> BDC ( )Tj EMC (\(87%\))Tj -1.804 -1.2 Td (19/27)Tj /Span<>> BDC ( )Tj EMC (\(70,4%\) )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -1.252 -1.2 Td (7/27)Tj /Span<>> BDC ( )Tj EMC (\(25,9%\))Tj /T1_2 1 Tf ( BMPR1A/PTEN)Tj /T1_1 1 Tf 2.102 -1.2 Td (1/27)Tj /Span<>> BDC ( )Tj EMC (\(3,7%\) )Tj /T1_2 1 Tf (PTEN)Tj /T1_1 1 Tf 13.982 3.6 Td (19 )Tj /T1_2 1 Tf (SMAD4)Tj /T1_1 1 Tf -0.034 -1.2 Td (6 )Tj /T1_2 1 Tf (BMPR1A)Tj /T1_1 1 Tf 0.633 -1.2 Td (1 )Tj /T1_2 1 Tf (PTEN)Tj /T1_1 1 Tf 6.652 2.4 Td (1 )Tj /T1_2 1 Tf (BMPR1A/PTEN)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\001\032)50(\f)42(\032\214\027 \007\036)30.1(\235\240\033)30(\f)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_6 1 Tf 25 0 0 25 512.0519 56.0378 Tm (17)Tj ET endstream endobj 1684 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.003 Tw 10 0 0 10 70.8661 517.8039 Tm [(\023\030\017\n\036\030\026 )0.5(\023\030\017\r\036\007\036\n )0.6(\023\026\006\017\036\027\021\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 12.79 0 Td [(\036\020\024 )0.5(\030\024\007\024\f\035\024\r\027\031\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 7.994 0 Td (\027\026)Tj 0 Tw (-)Tj 0.024 Tw -20.784 -1.218 Td (\035\017\004\017\036\n \r\026\030\017\026\027\021\026 c.425-6A)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (G \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026 )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf 0.024 Tw (, \022\024\021\024\030\t\036 )Tj 0 Tw 0 -1.218 TD (\023\030\036\007\f\021\026\r\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\031\027\022\026\b 2 \017)Tj /Span<>> BDC ( )Tj EMC (3, \f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj 0.168 Tw T* (\025\030\026\005\027\036 \r\026\032\027\024 \024\021\n\036\021\017\021\034\ , \004\021\024 \f\030\036\007\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.343 Tw T* (\035\017\004\017\036\n \021\024\035\034\022\024 \026\007\036\027\024\n\026\ \021\024\027\t\b \023\024\035\017\023\024\r, \002\t\035\024 \024\002)Tj 0 Tw (-)Tj 0.199 Tw T* (\027\026\030\031\032\036\027\024 2 \r\026\030\017\026\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_1 1 Tf 0 Tw [(BMP)66(R1A )]TJ /T1_0 1 Tf 0.199 Tw 16.404 0 Td (\(c.1081C)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (T; )Tj 0.138 Tw -16.404 -1.218 Td [(del )0.6(9\22613)]TJ /Span<>> BDC ( )Tj EMC 4.023 0 Td [(e)-18(x\) )0.6(\017)]TJ /T1_1 1 Tf 0 Tw /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 0.138 Tw 2.558 0 Td [(3 )0.6(\r\026\030\017\026\027\021\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.859 0 Td (\020\036\027\036 )Tj /T1_1 1 Tf 0 Tw 2.185 0 Td (SMAD4 )Tj /T1_0 1 Tf 0.138 Tw 3.061 0 Td [(\(dup )0.6(2-12; )]TJ 0 Tw -17.687 -1.218 Td (c.705dup; c.705dup\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 396.0239 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.096 Tw 10 0 0 10 70.8661 371.6679 Tm [(\215\030\017 \f\024\024\021\r\036\021\f\021\r\017\017 \022\035\017\027\017\ \004\036\f\022\017\n \022\030\017\021\036\030\017\016\n )0.5(\033\r\036\027\017\035\034)]TJ 0 Tw (-)Tj -0.039 Tw T* (\027\024\020\024 \023\024\035\017\023\024\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \023\036\030\r\t\n \220\021\026\023\024\ \n \024\023\030\036\007\036\035\016\033\021 )Tj 0.175 Tw T* (\023\026\021\024\020\036\027\027\t\036/\r\036\030\024\016\021\027\024 \023\ \026\021\024\020\036\027\027\t\036 \r\026\030\017\026\027\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj /T1_1 1 Tf 0 Tw T* [(BMP)66(R1A)]TJ /T1_0 1 Tf -0.028 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf -0.028 Tw (. \211)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \f\n\036\001\026\027\027\024\020\024 )Tj 0.073 Tw T* (\023\024\035\017\023\024\026 \017\035\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (20 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \026\007\036\027\024\n\026\021\024)Tj 0 Tw (-)Tj 0.161 Tw T* (\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036, \023\030\036\032\007\036\ )Tj 0.075 Tw T* [(\r\f\036\020\024, )0.5(\024\023\030\036\007\036\035\016\033\021 )0.5(\023\026\021\024\020\036\027\027\t\036/\r\036\030\024\016\021\027\024 )0.6(\023\026\021\024\020\036\027\027\t\036 )]TJ 0.104 Tw T* (\r\026\030\017\026\027\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj /T1_1 1 Tf 0 Tw (APC)Tj /T1_0 1 Tf 0.104 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.01 Tc -0.01 Tw 10.356 0 Td [(MUT)-54(YH)]TJ 0 Tc 0 Tw 2.786 0 Td (, )Tj /T1_0 1 Tf 0.104 Tw 0.541 0 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \017\b \024\021\f\031\021\f\021\r\017\017 )Tj 0.285 Tw -13.683 -1.218 Td (\023\030\017\n\036\027\016\033\021 \n\036\021\024\007 \023\024\035\027\024\ \220\022\024\n\027\024\020\024 \f\036\022\r\036\027\017\030\024\r\026\027\ \017\016 )Tj 0.132 Tw T* ([18\22620]. \230\n\036\027\027\024 \021\026\022\024\005 \026\035\020\024\ \030\017\021\n \023\024\r\024\035\016\036\021 \007\017\026\020\027\024)Tj 0 Tw (-)Tj 0.219 Tw T* (\f\021\017\030\024\r\026\021\034 \027\026\035\017\004\017\036 \f\017\027\ \007\030\024\n\026 \033\r\036\027\017\035\034\027\024\020\024 \023\024\035\ \017\023\024)Tj 0 Tw (-)Tj 0.229 Tw T* [(\026 )0.5(\027\036 )0.6(\021\024\035\034\022\024 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 6.915 0 Td [(\002\024\035\034\027\t\b )0.6(\f\024 )0.5(\f\n\036\001\026\027\027\t\n\017 )0.5(\023\024\035\017\023\026\n\017 )]TJ 0.347 Tw -6.915 -1.218 Td (\(\026\007\036\027\024\n\026\021\024\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\t\036\) \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036, )Tj 0.093 Tw T* (\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \021\024\035\034\022\024 \026\007\036\027\ \024\n\026\021\024\027\t\b )Tj 0 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005.)Tj 0.173 Tw T* (\200 \027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017 \004\026\ \f\021\024\021\026 \023\026\021\024\020\036\027\027\t\b/\r\036\030\024\016\ \021)Tj 0 Tw (-)Tj 0.071 Tw T* (\027\024 \023\026\021\024\020\036\027\027\t\b \027\026\f\035\036\007\f\021\ \r\036\027\027\t\b \r\026\030\017\026\027\021\024\r \f\024\f\021\026\r\017\ \035\026 )Tj 0.047 Tw T* (64,3%, \004\021\024 \r\t\001\036 \023\024\007\024\002\027\024\005 \004\026\ \f\021\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\222\231\202, \206\036\030\n\026\027\017\017, )Tj 0.083 Tw T* (\230\030\026\017\035\036, \222\017\027\020\026\023\031\030\036, \027\024\ \027\017\032\036 \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\212\026\027\017\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\). )Tj 0.186 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 2.039 0 Td [(\220\021\024\n )0.5(\004\026\f\021\024\021\026 )0.5(\022\030\031\023\027\t\b )0.5(\023\036\030\036\f\021\030\024\036\022, )0.6(\r\t\016\r\035\036\027\027\t\b )]TJ 0.083 Tw -2.039 -1.218 Td (\027\026\n\017, \027\026\004\017\021\036\035\034\027\024 \r\t\001\036 \(\ 27,8%\), \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \f\021\030\026)Tj 0 Tw (-)Tj 0.045 Tw T* (\027\026\b, \004\021\024 \020\024\r\024\030\017\021 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 \r\022\035\033\004\036\027\ \017\016 \n\036\021\024\007\026 )Tj 0.271 Tw T* [(MLP)25(A \r)]TJ /Span<>> BDC ( )Tj EMC (\030\031\021\017\027\027\031\033 \212\203\025-\007\017\026\020\027\024\f\ \021\017\022\031 \007\035\016 \023\026\006\017\036\027\021\024\r )Tj 0.166 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\t\005 \023\024\035\017\023\024, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \f\035\031)Tj 0 Tw (-)Tj 0.029 Tw T* (\004\026\036, \022\024\020\007\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\036\022\r\036\027\017\030\024\r\026\027\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \222\220\027\020\036\030\026 \027\036 )Tj 0.095 Tw 23.244 43.841 Td [(\r\t\016\r\035\016\036\021\f\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 5.839 0 Td [(\027\017\b )0.5(\021\024\004\022\024\r\t\b )0.6(\027\026\f\035\036\007\f\021\r\036\027\027\t\b )0.6(\r\026\030\017\026\027)]TJ 0 Tw (-)Tj 0.132 Tw -5.839 -1.218 Td (\021\024\r. \025\030\024\n\036 \021\024\020\024, \r)Tj /Span<>> BDC ( )Tj EMC [(5 \f\036\n\034\016\b )0.5(\027\026\005\007\036\027\t \030\026\027\036\036 )0.5(\027\036 \024\023\017)]TJ 0 Tw (-)Tj 0.089 Tw T* (\f\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\036 \020\036\030\n\017\027\026\035\034\027\t\036 \r\026\030\017\ \026\027\021\t \(3)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_1 1 Tf 0 Tw T* [(BMP)66(R1A)]TJ /T1_0 1 Tf 0.009 Tw (, \017)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036 )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf 0.009 Tw (\) \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \r\f\036\b \031\f\021\026\027\024\r\035\036\027\024 )Tj 0.179 Tw T* (\r\036\030\024\016\021\027\024 \023\026\021\024\020\036\027\027\024\036 \ \027\026\004\036\027\017\036. \222\021\024\017\021 \024\021\n\036\021\017\ \021\034, \r\f\036 )Tj 0.112 Tw T* [(\027\024\r\t\036 \r\026\030\017\026\027\021\t )0.5(\030\026\f\023\024\035\026\020\026\033\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\027\t\b )0.5(\004\026\f\021\016\b \017\f)]TJ 0 Tw (-)Tj 0.015 Tw T* (\f\035\036\007\031\036\n\t\b \020\036\027\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036 \r)Tj /Span<>> BDC ( )Tj EMC (\253\020\024\030\016\004\017\b \031\004\026\f\021\022\026\b\273. \215\024\ \220\021\024\n\031 )Tj 0.09 Tw T* (\027\036\024\002\b\024\007\017\n\024 \f\036\022\r\036\027\017\030\024\r\026\ \021\034 \r\f\033 \022\024\007\017\030\031\033\013\031\033 \023\024\f\035\ \036)Tj 0 Tw (-)Tj 0.394 Tw T* (\007\024\r\026\021\036\035\034\027\024\f\021\034 \020\036\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\035\036\020\026\033\013\017\n\017 \017\027\021\030\024\027\027\ \t\n\017 )Tj 0 Tw T* (\024\002\035\026\f\021\016\n\017.)Tj 0.19 Tw T* (\211 \023\026\006\017\036\027\021\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \027\036 \017\007\036\027\021\017\235\017\006\017\ \030\024\r\026\027 \023\026\021\024)Tj 0 Tw (-)Tj 0.027 Tw T* (\020\036\027\027\t\005/\r\036\030\024\016\021\027\024 \023\026\021\024\020\ \036\027\027\t\005 \r\026\030\017\026\027\021 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj /T1_1 1 Tf 0 Tw (SMAD4)Tj /T1_0 1 Tf ( )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.864 0 Td [(BMP)66(R1A)]TJ /T1_0 1 Tf 0.113 Tw (, \030\036\022\024\n\036\027\007\031\036\021\f\016 \017\f\f\035\036\007\024\ \r\026\021\034 \020\036\027 )Tj /T1_1 1 Tf 0 Tw (PTEN )Tj /T1_0 1 Tf 19.71 0 Td ([7]. )Tj 0.065 Tw -20.574 -1.218 Td (\210\007\027\026\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\017\017 )0.5(\023\024\035\027\024\220\022\024\n\027\024\020\024 \f\036\022\r\036\027\ \017\030\024)]TJ 0 Tw (-)Tj 0.161 Tw T* (\r\026\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\017\b \023\026\006\017\036\027\021\024\r \023\026\021\024\020\ \036\027\027\t\b/\r\036\030\024\016\021\027\024 \023\026)Tj 0 Tw (-)Tj 0.065 Tw T* (\021\024\020\036\027\027\t\b \r\026\030\017\026\027\021\024\r \020\036\027\ \026 )Tj /T1_1 1 Tf 0 Tw (PTEN)Tj /T1_0 1 Tf 0.065 Tw ( \024\002\027\026\030\031\032\036\027\024 \027\036 \002\t\035\024. )Tj 0.268 Tw T* (\222\024\020\035\026\f\027\024 \017\027\235\024\030\n\026\006\017\017, \024\ \007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \023\024\035\027\t\b )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \001\020\024\f\027\030\024\023\021\027\025\025\013\027 \021\020\032\022\ \020\025\023\013 \b\027\025\020 SMAD4 \(NM_005359.6\) \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.318 0 Td [( H)-1(e)-6(r)-2(e)-12.9(d)-2.9(i)-3.4(t)-2(a)-4.2(r)-43.8(y v)6.3(a)-4.2(r)-38.9(i)1.5(a)-5.1(n)-0.6(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e S)14(M)5.3(A)10(D)1(4 g)-6.8(e)-7(n)-2.4(e \()29.6(N)5.5(M)4.1(_)-51.6(0)-10.6(0)6.8(5)23.9(3)26(5)20.3(9)31.5(.)24.1(6)39.5(\) \()61.7(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(7)40.1(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 354.5807 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 673.2926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 694.1118 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 673.2926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 354.5807 694.1118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 673.2926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 694.1118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 673.2926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 673.2926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 673.0426 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 652.2313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 156.1555 673.0426 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 652.2313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 354.5807 673.0426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 652.2313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 411.2736 673.0426 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 652.2313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 652.2313 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 651.9813 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 631.17 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 156.1555 651.9813 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 631.17 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 354.5807 651.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 631.17 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 411.2736 651.9813 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 631.17 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 631.17 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 630.92 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 619.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 630.92 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 619.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 354.5807 630.92 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 619.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 630.92 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 619.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 619.7087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 619.4587 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 598.6395 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 619.4587 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 598.6395 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 354.5807 619.4587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 598.6395 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 619.4587 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 598.6395 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 598.6395 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 598.3895 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 577.5782 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 156.1555 598.3895 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 577.5782 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 354.5807 598.3895 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 577.5782 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 411.2736 598.3895 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 577.5782 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 577.5782 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 577.3282 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 556.517 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 156.1555 577.3282 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 156.1555 556.517 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 354.5807 577.3282 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 354.5807 556.517 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 411.2736 577.3282 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 556.517 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 556.517 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 556.267 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 556.267 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 354.5807 556.267 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 411.2736 556.267 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 81.6283 701.7465 Tm (\020\002\201\220\002\013\005 \004\006\t\004\b\003)Tj 15.901 0 Td (\200\006\002\003\235\202\221\b\b\004\235 \212\r\006\r\217\003\006\002\005\ \220\004)Tj 20.283 0.6 Td (\025\002\013\005 )Tj -0.278 -1.2 Td (\004\006\t\004\b\003)Tj 6.812 0.6 Td (\200\004\003\002\n\r\b\b\002\217\003\001 \(\220\006\t\003\r\006\t\t\))Tj /T1_0 1 Tf -43.677 -2.033 Td (c.346C)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (T)Tj T* (p.\(Gln116Ter\))Tj 22.399 1.2 Td (\226)Tj 15.744 0 Td (\007\026)Tj /T1_3 1 Tf 10.58 -0.001 Td (LP)Tj /T1_0 1 Tf -3.201 -1.2 Td (PVS1)Tj /Span<>> BDC ( )Tj EMC (\(VS\) PM2)Tj /Span<>> BDC ( )Tj EMC (\(M\))Tj -45.522 -1.433 Td (\226)Tj 12.513 0 Td (dup 2-12 [NC_000018.8 g.\(46811230_46827460\)_)Tj 6.386 -1.2 Td (\(46858720_?\)dup])Tj 19.445 1.2 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -2.633 Td (c.1081C)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (A)Tj T* (p.\(Arg361Ser\))Tj 22.399 1.2 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -2.633 Td (c.425-6A)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (G)Tj 22.399 0 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj /T1_3 1 Tf -48.974 -1.434 Td (c.705dup*)Tj /T1_0 1 Tf 0 -1.2 TD (p.\(Gly236ArgfsTer28\))Tj 22.399 1.201 Td (\226)Tj 15.744 0 Td (\007\026)Tj /T1_3 1 Tf 10.58 -0.001 Td (LP)Tj /T1_0 1 Tf -3.201 -1.2 Td (PVS1)Tj /Span<>> BDC ( )Tj EMC (\(VS\) PM2)Tj /Span<>> BDC ( )Tj EMC (\(M\))Tj -45.522 -1.433 Td (c.403C)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (T)Tj T* (p.\(Arg135Ter\))Tj 22.399 1.2 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -2.633 Td (\226)Tj 14.551 0 Td (del 1 ex [NC_000018.8 g.\(?_46810320\)_)Tj 2.708 -1.2 Td (\(46811230_46827460\)del])Tj 21.085 1.2 Td (\226)Tj 10.63 0 Td (\226)Tj /T1_1 1 Tf 7 0 0 7 70.8661 544.7823 Tm (\004\032\022\026\027\007\020\025\022\027: LP)Tj /Span<>> BDC ( )Tj EMC [(\227 lik)17.2(ely pathog)12.1(enic \(\021\027\032\031\t\023\025\031 \033\020)49.1(\023\031\b\027\025\025\013\235\); *)]TJ /Span<>> BDC ( )Tj EMC (\227 \021\020\032\022\020\025\023 \031\240\025\020\032\r\255\027\025 \r)Tj /Span<>> BDC ( )Tj EMC (3 \033\031\032\020\255\027\025\025\013\200 \032\031\030\024\023\021\027\025\ \025\022\n\031\021 \022\016)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\235 \024\027\026\017\022.)Tj ET q 303.307 165.77 221.102 142.699 re W n q /GS0 gs 221.1023475 0 0 142.8402789 303.3070555 165.6285281 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.034 Tw 9 0 0 9 303.3071 154.9701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \206\031\030\031\024\f\031\021\025\020\t )0.5(\033\020\006\022\027\025\023\020 \024)]TJ /Span<>> BDC ( )Tj EMC (\205\224\004 \022)Tj /Span<>> BDC ( )Tj EMC [(\033\020\023\031\b\027\025\025\013\026 )0.5(\021\020)]TJ 0 Tw (-)Tj 0 -1.2 TD (\032\022\020\025\023\031\026 c.425-6A)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (G \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 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(c.385T)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (G )Tj -0.003 Tw -17.67 -1.218 Td [(p.\(L)35(eu129V)25(al\) \017)]TJ /Span<>> BDC ( )Tj EMC (c.94G)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(C p.\(Gl)35(y32Ar)-31.9(g\). \211)]TJ /Span<>> BDC ( )Tj EMC (8 \023\030\024\002\026\027\007\024\r )Tj -0.029 Tw 23.244 7.307 Td (\017)Tj /Span<>> BDC ( )Tj EMC (28 \f\036\n\036\005 \(28,6%\) \027\026\f\035\036\007\f\021\r\036\027\027\ \t\b \r\026\030\017\026\027\021\024\r \020\036\027\024\r )Tj /T1_2 1 Tf 0 Tw T* [(BMP)66(R1A )]TJ /T1_1 1 Tf (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf (SMAD4 )Tj /T1_1 1 Tf (\024\002\027\026\030\031\032\036\027\024 \027\036 \002\t\035\024 \(\221\026\ \002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.278 Tw T* (\200 \020\036\027\036 )Tj /T1_2 1 Tf 0 Tw [(BMP)65.9(R1A )]TJ /T1_1 1 Tf 0.278 Tw 7.087 0 Td (\r\t\016\r\035\036\027\024 11 \023\026\021\024\020\036\027\027\t\b/\r\036\ \030\024\016\021\027\024 )Tj 0.083 Tw -7.087 -1.218 Td (\023\026\021\024\020\036\027\027\t\b \r\026\030\017\026\027\021\024\r, \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b 3)Tj /Span<>> BDC ( )Tj EMC (\227 \022\030\031\023\027\t\036 \007\036)Tj 0 Tw (-)Tj T* (\035\036\006\017\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.138 Tw T* (\200 \020\036\027\036 )Tj /T1_2 1 Tf (SMAD4)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj /T1_1 1 Tf (7 \r\026\030\017\026\027\021\024\r, \f\030\036\007\017 \027\017\b 1 \022\ \030\031\023\027\026\016 )Tj -0.036 Tw T* (\007\036\035\036\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (1 \022\030\031\023\027\026\016 \007\031\023\035\017\022\026\006\017\016 \ \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\). \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \206\027\016\r\f\017\023\020\023\013 \026\031\f\027\n\r\f\t\032\025\031\ -\b\027\025\027\023\022\007\027\024\n\031\b\031 \022\024\024\f\027\030\031\ \021\020\025\022\t \024\027)0.5(\026\027\235 \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (28\), \021\n\f\005\007\027\025\025\013\200 \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( R)2.8(e)-22(s)6.7(u)-1.5(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(m)-5.2(o)-5.3(le)-10.9(c)-0.6(u)-1.6(l)-1.1(a)-4.2(r g)-6.7(e)-7(n)-2.4(e)-8.6(t)-29.1(i)-1.8(c s)-14.8(t)-1.1(u)-5.9(d)-7.1(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e f)-8.1(a)-5(m)1.3(i)2.9(li)-1.4(e)-22(s \()61.7(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(2)18.8(8)47.2(\) i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.2(e)-12.9(d i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 255.368 0 l S Q q 1 0 0 1 42.7697 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 715.181 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7118 cm 0 0 m 255.368 0 l S Q q 1 0 0 1 42.7697 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 703.7118 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 703.7118 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 692.2426 cm 0 0 m 255.368 0 l S Q q 1 0 0 1 42.7697 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 692.2426 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 692.2426 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7813 cm 0 0 m 255.368 0 l S Q q 1 0 0 1 42.7697 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 680.7813 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 680.7813 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.32 cm 0 0 m 255.368 0 l S Q q 1 0 0 1 297.8878 669.32 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 397.1004 669.32 cm 0 0 m 99.463 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 123.2773 706.5464 Tm (\025\004\217\f\r\240\217\003\r\b\b\013\r \004\006\t\004\b\003\013)Tj 26.909 0 Td (\027\r\b\013)Tj 11.853 0 Td (\030\004\217\003\002\003\004)Tj /T1_1 1 Tf -48.471 -1.434 Td (\215\026\021\024\020\036\027\027\t\036)Tj /T1_3 1 Tf (/)Tj /T1_1 1 Tf (\r\036\030\024\016\021\027\024 \023\026\021\024\020\036\027\027\t\036)Tj /T1_2 1 Tf 34.645 0.001 Td (SMAD4 BMPR1A)Tj /T1_1 1 Tf 12.563 0 Td (18/28)Tj /Span<>> BDC ( )Tj EMC (\(64,3%\))Tj -47.208 -1.434 Td (\200\026\030\017\026\027\021\t \027\036\016\f\027\024\020\024 \027\026\004\ \036\027\017\016)Tj /T1_2 1 Tf 36.107 0 Td (BMPR1A)Tj /T1_1 1 Tf 11.601 0 Td (2/28)Tj /Span<>> BDC ( )Tj EMC (\(7,1%\))Tj -47.708 -1.433 Td (\210\021\f\031\021\f\021\r\031\033\021)Tj 37.458 0 Td (\226)Tj 10 0 Td (8/28)Tj /Span<>> BDC ( )Tj EMC (\(28,6%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 652.6008 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \001\020\024\f\027\030\024\023\021\027\025\025\013\027 \021\020\032\022\ \020\025\023\013 \b\027\025\020 BMPR1A \(NM_004329.3\) \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (11\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( H)-1(e)-6(r)-2(e)-12.8(d)-3(i)-3.4(t)-2(a)-4.2(r)-43.8(y v)6.3(a)-4.2(r)-38.9(i)1.5(a)-5.1(n)-0.6(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.3(e B)5.3(M)8(P)22.6(R)16.3(1)15.3(A g)-6.8(e)-7(n)-2.4(e \()29.7(N)5.4(M)4.1(_)-51.6(0)-10.6(0)-4.7(4)13.7(3)27.3(2)12.9(9)31.5(.)0.9(3)68.4(\) \()61.7(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1)57.6(1)84.6(\))]TJ ET /GS2 gs q 1 0 0 1 42.5197 637.2988 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 616.4796 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 127.809 637.2988 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 616.4796 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 326.2342 637.2988 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 616.4796 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9271 637.2988 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 616.4796 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 616.4796 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 616.2296 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 576.2103 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 127.809 616.2296 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 576.2103 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 326.2342 616.2296 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 576.2103 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 382.9271 616.2296 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 576.2103 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 496.313 576.2103 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 42.5197 575.9603 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 555.149 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.809 575.9603 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 555.149 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2342 575.9603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 555.149 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9271 575.9603 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 555.149 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 555.149 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 554.899 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 534.0878 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.809 554.899 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 534.0878 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2342 554.899 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 534.0878 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9271 554.899 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 534.0878 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 534.0878 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 533.8378 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 513.0265 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.809 533.8378 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 513.0265 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2342 533.8378 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 513.0265 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9271 533.8378 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 513.0265 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 513.0265 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 512.7765 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 482.3573 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 127.809 512.7765 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 482.3573 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 326.2342 512.7765 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 482.3573 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 382.9271 512.7765 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 482.3573 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 482.3573 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 482.1073 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 470.896 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.809 482.1073 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 470.896 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2342 482.1073 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 470.896 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9271 482.1073 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 470.896 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 470.896 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 470.646 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 449.8347 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.809 470.646 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 449.8347 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2342 470.646 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 449.8347 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9271 470.646 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 449.8347 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 449.8347 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 449.5847 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 438.3734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 127.809 449.5847 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 438.3734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2342 449.5847 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 438.3734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9271 449.5847 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 438.3734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 438.3734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 438.1234 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 407.7042 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 127.809 438.1234 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 407.7042 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 326.2342 438.1234 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 407.7042 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 382.9271 438.1234 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 407.7042 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 407.7042 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 407.4542 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 386.6429 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.809 407.4542 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 386.6429 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2342 407.4542 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 386.6429 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9271 407.4542 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 386.6429 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 386.6429 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 386.3929 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 42.7697 365.5816 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 127.809 386.3929 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 127.809 365.5816 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2342 386.3929 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2342 365.5816 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 382.9271 386.3929 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 382.9271 365.5816 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 365.5816 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 365.3316 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 127.809 365.3316 cm 0 0 m 198.425 0 l S Q q 1 0 0 1 326.2342 365.3316 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9271 365.3316 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 53.2818 623.8642 Tm (\020\002\201\220\002\013\005 \004\006\t\004\b\003)Tj 15.901 0 Td (\200\006\002\003\235\202\221\b\b\004\235 \212\r\006\r\217\003\006\002\005\ \220\004)Tj 20.283 0.6 Td (\025\002\013\005 )Tj -0.278 -1.2 Td (\004\006\t\004\b\003)Tj 6.812 0.6 Td (\200\004\003\002\n\r\b\b\002\217\003\001 \(\220\006\t\003\r\006\t\t\))Tj /T1_1 1 Tf -43.677 -2.033 Td (c.675)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (4del)Tj 38.143 0 Td (\007\026)Tj /T1_3 1 Tf 10.302 -0.001 Td (LP*)Tj /T1_1 1 Tf -0.852 -1.2 Td (PM2)Tj /Span<>> BDC ( )Tj EMC (\(M\))Tj -0.544 -1.2 Td (PP3)Tj /Span<>> BDC ( )Tj EMC (\(supp\))Tj -0.369 -1.2 Td (PP1)Tj /Span<>> BDC ( )Tj EMC (\(Strong\))Tj -46.68 -1.433 Td (c.1081C)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (T)Tj T* (p.\(Arg361Ter\))Tj 38.344 1.2 Td (\226)Tj 10.63 0 Td (\226)Tj -36.872 -2.633 Td (del 9\22613)Tj /Span<>> BDC ( )Tj EMC (ex [NC_000010.9g.\(88662150_88667040\)_)Tj 6.944 -1.2 Td (\(88673810_?\)del])Tj 19.298 1.2 Td (\226)Tj 10.63 0 Td (\226)Tj -36.21 -2.633 Td (del 8 ex [NC_000010.9 g.\(88649700_88662150\)_)Tj 4.495 -1.2 Td (\(88662150_88667040\)del])Tj 21.085 1.2 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -2.633 Td (c.127_128del)Tj 0 -1.2 TD (p.\(Lys43ValfsTer27\))Tj 22.399 1.2 Td (\226)Tj 15.744 0 Td (\007\026)Tj /T1_3 1 Tf 10.58 -0.001 Td (LP)Tj /T1_1 1 Tf -1.426 -1.2 Td (PVS1)Tj /Span<>> BDC ( )Tj EMC (\(VS\))Tj 0.296 -1.2 Td (PM2)Tj /Span<>> BDC ( )Tj EMC (\(M\))Tj -47.593 -1.433 Td (c.333)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (5G)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (C)Tj 22.399 0 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -1.433 Td (c.128_137del)Tj 0 -1.2 TD (p.\(Lys43MetfsTer3\))Tj 22.399 1.2 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -2.633 Td (c.1473)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (1G)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (T)Tj 22.399 0 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -1.433 Td (c.1537_1559del)Tj T* (p.\(Thr513AlafsTer6\))Tj 22.399 1.2 Td (\226)Tj 15.744 0 Td (\007\026)Tj /T1_3 1 Tf 10.58 -0.001 Td (LP)Tj /T1_1 1 Tf -1.426 -1.2 Td (PVS1)Tj /Span<>> BDC ( )Tj EMC (\(VS\))Tj 0.296 -1.2 Td (PM2)Tj /Span<>> BDC ( )Tj EMC (\(M\))Tj -33.57 -1.433 Td (del 1\2265)Tj /Span<>> BDC ( )Tj EMC (ex [NC_000010.9 g.\(?_88506400\)_)Tj 3.236 -1.2 Td (\(88641940_88649630\)del])Tj 21.085 1.2 Td (\226)Tj 10.63 0 Td (\226)Tj -48.974 -2.633 Td (c.355C)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (T)Tj T* (p.\(Arg119Cys\))Tj 22.399 1.2 Td (\226)Tj 15.945 0 Td (\226)Tj 10.63 0 Td (\226)Tj /T1_2 1 Tf 7 0 0 7 42.5197 353.847 Tm (\004\032\022\026\027\007\020\025\022\027: LP)Tj /Span<>> BDC ( )Tj EMC [(\227 lik)17.2(ely pathog)12.1(enic \(\021\027\032\031\t\023\025\031 \033\020)49.1(\023\031\b\027\025\025\013\235\))]TJ ET q 42.52 122.57 453.543 111.577 re W n q /GS0 gs 453.543294 0 0 111.586052 42.5196838 122.5605239 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.096 Tw 9 0 0 9 42.5197 111.7701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\027\n\021\027\025\031\b\032\020\026\026\020 \033\020\023\031\b\027\ \025\025\031\b\031 \021\020\032\022\020\025\023\020 c.425-6A)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (G \(\r\n\020\016\020\025 \024\023\032\027\f\n\031\235\) \021)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\030\031\021\020\023\027\f\017\025\031\024\023\022 \b\027\ \025\020 SMAD4 )Tj 0 Tw T* (\(NM_005359.6\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.19 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Seq)14(uenog)14(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the pathog)12.1(enic v)16(ar)-37(iant c.425-6A)]TJ /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(G \(indicated by ar)-15.9(row\) in the)]TJ /Span<>> BDC ( )Tj EMC [(seq)14(uence of)]TJ /Span<>> BDC ( )Tj EMC [(the SMAD4 g)12(ene )]TJ 0 Tw T* (\(NM_005359.6\))Tj ET 1 0.68 0 0.12 K 1.5 w 4 M /GS0 gs q 1 0 0 1 252.0709 195.6348 cm 0 0 m 0 -35.437 l S Q q 1 0 0 1 255.2806 169.0186 cm 0 0 m -3.21 -8.82 l -6.42 0 l S Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\001\032)50(\f)42(\032\214\027 \007\036)30.1(\235\240\033)30(\f)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_4 1 Tf 25 0 0 25 511.9395 56.0378 Tm (15)Tj ET endstream endobj 1756 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""    g!1"AQ#45aqst$2B%3RSTu &'()6br*789:CDEFGHIJUVWXYZcdefghijvwxyz#]!1AQaq"2BRb$3C #%&'()*456789:DEFGHcrsIJSTUVWXYZdefghijtuvwxyz?TD@|}D_.DDD@DD}D_EKt ν܋ tӈ׀i&aDDD@DDD@DD|_PD]fh9E[ë/MI7+W1mv_.|_PD_.DD|_PDD˄}DD]m'<ƺf.U]QS9\p/>/@D@˅EQD@EoD}DD>Dɞ>Fo@4̯ " />"\/"p""TD@|L FL/5Q1w׶ zJ 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eM#{ɘ~GYB-،<4tJIKU=;'oSzi[lTE~ #M`х^ 1Fdu^?VM:)R̼^xl-f7<>CNsw9;uX<{E_vNj/*͸ o NNrz:Z+\jeQUo%/Zh4+=WZ+0zPJz7frv؊/rĨRp8:2KFw8}vF׀s(v]43?3:3eOkt OĮ/jð8%USEubš4Tš6%E3[ŹWql:QO-y4%,=uAU&>JRVE;NrZiCtCRM8î)Q5Tm{:Sjxm]PUwT%("8K.'VY(v>zF!tB̐ K}뭢a-}-3=~a0ԩNw0:ux&U>$UjIfV7eN^+5?Am>'*gP@hbo"&FM=+xdr2 (ˉN$Hf~5ƃׅ_^&uRҩ&\*S^QJJwaǍa$%4ՖuʧI!dyccZ8"j*]זy3nuU7~;ʹpW8nGڇ F%梜*M[TaDETD@|D@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@DDD@ endstream endobj 1757 0 obj <>stream endstream endobj 1753 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.007 Tw 10 0 0 10 70.8661 724.8299 Tm (\021\036\f\021\017\030\024\r\026\027\017\016, \r\022\035\033\004\026\016\ \024\007\027\024\r\030\036\n\036\027\027\024\036 \021\036\f\021\017\030\ \024\r\026\027\017\036 )Tj 0 Tw 0 -1.218 TD (\020\036\027\024\r )Tj /T1_1 1 Tf 2.741 0 Td [(BMP)66(R1A)]TJ /T1_0 1 Tf 0.186 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (SMAD4, )Tj /T1_0 1 Tf 0.186 Tw 7.863 0 Td (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\036 \021\036\f\021\ \017\030\024)Tj 0 Tw (-)Tj 0.341 Tw -10.603 -1.218 Td (\r\026\027\017\036 \022\026\032\007\024\020\024 \020\036\027\026, \017\f\ \023\024\035\034\024\r\026\027\017\036 \n\031\035\034\021\017\020\036\027\ \027\024\005 )Tj 0.324 Tw T* (\023\026\027\036\035\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\017\n\036\027\036\027\017\036 \023\024\035\ \027\024\220\022\024\n\027\024\020\024 \017\035\017 )Tj 0.054 Tw T* (\023\024\035\027\024\020\036\027\024\n\027\024\020\024 \f\036\022\r\036\027\ \017\030\024\r\026\027\017\016 [8]. \212\035\016 \023\026\006\017\036\027\ \021\024\r )Tj 0.111 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\n\017 \023\030\017\027\026\022\026\ \n\017 \f\017\027\007\030\024\n\026 \033\r\036\027\017\035\034\027\024\020\ \024 )Tj 0.428 Tw 0 -1.218 TD (\023\024\035\017\023\024\026 \027\036\024\002\b\024\007\017\n\024 \023\030\ \024\r\024\007\017\021\034 \n\024\035\036\022\031\035\016\030\027\024-\020\ \036)Tj 0 Tw (-)Tj 0.345 Tw 0 -1.218 TD [(\027\036\021\017\004\036\f\022\024\036 )0.6(\021\036\f\021\017\030\024\r\026\027\017\036 )0.6(\020\036\027\024\r )]TJ /T1_1 1 Tf 0 Tw 14.349 0 Td [(BMP)66(R1A)]TJ /T1_0 1 Tf 0.345 Tw [( )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 4.866 0 Td (SMAD4,)Tj /T1_0 1 Tf ( )Tj 0.266 Tw -19.215 -1.218 Td [(\r\022\035\033\004\026\016 )0.6(\026\027\026\035\017 )0.5(\023\030\024\n\024\021\024\030\027\t\b )0.6(\024\002\035\026\f\021\036\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.63 0 Td (\022\030\031\023\027\t\b )Tj 0 Tw -18.63 -1.218 Td (\007\036\035\036\006\017\005/\007\031\023\035\017\022\026\006\017\005)Tj /Span<>> BDC ( )Tj EMC ([8].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 578.6938 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.204 Tw 10 0 0 10 70.8661 554.3378 Tm (\215\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\021\034 \030\036\ \031\035\034\021\026\021\t \n\024\035\036\022\031\035\016\030\027\024-\020\ \036\027\036)Tj 0 Tw (-)Tj 0.273 Tw T* [(\021\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016 )0.5(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n \033\r\036\027\017\035\034\027\024\020\024 \023\ \024\035\017\023\024\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 493.4478 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.002 Tc 0.346 Tw 10 0 0 10 70.8661 469.0918 Tm (\204\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\ \036\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \023\030\024\ \r\036\007\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.066 Tw T* [(\027\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 2.063 0 Td [(30 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.194 0 Td [(28 )0.6(\f\036\n\036\005 )0.5(\(\r )0.6(\024\007\027\024\005 )0.6(\f\036\n\034\036 )0.5(\002\t\035\024)2( )]TJ 0.045 Tw -9.257 -1.218 Td [(\f\030\026\031 )0.5(3 )0.5(\023\024\030\026\032\036\027\027\t\b )0.5(\030\024\007\f\021\r\036\027\027\017\022\026\), )0.6(\022\024\021\024\030\t\036 )0.5(\027\026\002\035\033)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.128 Tw T* (\007\026\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (2012 \023\024)Tj /Span<>> BDC ( )Tj EMC (2024 \020\020. \215\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 \220\ \027\007\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.447 Tw T* [(\f\022\024\023\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\ \027\017\016 \021\024\035\f\021\024\005 \022\017\001\022\017 \002\t\035\024\ )2( )]TJ 0.221 Tw T* [(\031\f\021\026\027\024\r\035\036\027\024, \004\021\024 \f\030\036\007\017\ 30 \002\024\035\034\027\t\b \024\023\030\036\007\036\035\016\033\021\f\016\ :)2( )]TJ 0.23 Tw T* (14 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\033\r\036\027\017\035\034\027\t\n\017 \023\024\035\017\023\026\n\017 \r\ )Tj /Span<>> BDC ( )Tj EMC [(\021\024\035\f\021\024\005)2( )]TJ 0.071 Tw T* [(\022\017\001\022\036, 11 \023\026\006\017\036\027\021\024\r \f\024 \f\n\036\ \001\026\027\027\t\n\017 \(\033\r\036\027\017\035\034\027\t\n\017)2( )]TJ 0.155 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\027\024\n\026\021\024\027\t\n\017\) \023\024\035\017\023\026\ \n\017 \017)Tj /Span<>> BDC ( )Tj EMC (5)Tj /Span<>> BDC ( )Tj EMC (\227 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.167 Tw T* (\027\024\n\026\021\024\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\ \026\027\017\016\n\017, \031)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\b \030\026\027\036\036)2( )]TJ 0.184 Tw 23.244 36.534 Td [(\023\030\024\r\036\007\036\027\027\026\016 \212\203\025-\007\017\026\020\ \027\024\f\021\017\022\026 \023\024\022\026\026\035\026 \024\021\f\031\021\ \f\021\r\017\036)2( )]TJ 0.329 Tw 0 -1.218 TD (\023\026\021\024\020\036\027\027\t\b \r\026\030\017\026\027\021\024\r \r\ )Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj /T1_1 1 Tf -0.002 Tw (APC/)Tj 0.012 Tc -0.012 Tw 16.032 0 Td [(MUT)-54(YH)]TJ /T1_0 1 Tf 0.002 Tc 0.329 Tw 2.796 0 Td [(. \222\b\036\n\026)2( )]TJ 0.183 Tw -18.828 -1.218 Td [(\007\017\026\020\027\024\f\021\017\004\036\f\022\024\020\024 \024\002\f\035\ \036\007\024\r\026\027\017\016 \023\026\006\017\036\027\021\024\r \031\022\ \026\026\027\026)2( )]TJ 0 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f.)Tj /Span<>> BDC ( )Tj EMC (1.)Tj 0 Tc 0.49 Tw 0 -1.218 TD (\212\203\025 \r\t\007\036\035\016\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\235\036\030\017\004\036\f\022\024\005 \022\030\024\r\017\ \023\026\006\017)Tj 0 Tw (-)Tj 0.335 Tw 0 -1.218 TD (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \026\r\021\024\n\026\021\017\004\036\f\022\024\ \005 \f\021\026\027\006\017\017 Ma)-17(gNa )]TJ 0.106 Tw 0 -1.218 TD [(P)20(ur)-24(e Com)10(p)32(a)-17(c)-16(t, \017\f\023\024\035\034\031\016 \027\026\002\024\030 Ma)-17(gNa P)20(ur)-23.9(e Com)9.9(p)32.1(a)-17(c)-16(t )]TJ -0.049 Tw 0 -1.218 TD [(Nucleic A)-25(c)-24(id Isol)-16(a)15(t)-32(ion Ki)-24(t \(R)11(o)-16(che\). \025\024\027\006\036\027\021\030\026\006\017\033 \212\203\025 )]TJ 0.003 Tw T* (\017\n\036\030\016\035\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \023\030\017\002\024\030\026 Denov)-16(ix, \017\f\023\024\035\034\031\016 \027\026)]TJ 0 Tw (-)Tj 0.092 Tw T* [(\002\024\030 Q)-16(ubi)-23.9(t HS assa)15(y \(T)47(her)-15.9(mo F)-19(isher\). )0.5(\222\036\022\r\036\027\017\030\024\r\026\027\017\036 )]TJ 0 Tw T* (\020\036\027\024\r )Tj /T1_1 1 Tf 2.605 0 Td (SMAD4)Tj /T1_0 1 Tf 0.051 Tw [( )0.5(\017)]TJ /T1_1 1 Tf /Span<>> BDC ( )Tj EMC 3.776 0 Td [(BMP)66(R1A )]TJ /T1_0 1 Tf 3.476 0 Td [(\(\220\022\024\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 4.333 0 Td [(\023\030\017\035\036\020\026\033\013\017\n\017 )0.6(\017\027)]TJ 0 Tw (-)Tj 0.144 Tw -14.191 -1.218 Td [(\021\030\024\027\026\n\017\) )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\n\036\021\024\007\031 \222\220\027\020\036\030\026 )0.5(\023\030\024\r\024\007\017\035\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\002\024\030\036 )Tj 0.049 Tw T* [(\253A)44(BI PRISM 3500\273 \(8 capill)-15.9(ar)-37(ies; Appl)-30.9(ied Biosy)-12.9(stems\), )]TJ 1.531 Tw T* (\017\f\023\024\035\034\031\016 \024\030\017\020\017\027\026\035\034\027\ \t\036 \023\030\026\005\n\036\030\t-\026\021\030\026\r\022\017. )Tj 0.147 Tw T* [(\025\030\031\023\027\t\036 \023\036\030\036\f\021\030\024\005\022\017 \007\ \036\021\036\022\021\017\030\024\r\026\035\017 \n\036\021\024\007\024\n \ MLP)25.1(A )]TJ 0.28 Tw T* [(\(MRC Holl)-16(and SALSA MLP)25(A P)35(r)-32(obemix P158-D1 JPS\). )]TJ 0.174 Tw T* [(\215\024\035\027\024\220\022\024\n\027\024\036 \f\036\022\r\036\027\017\ \030\024\r\026\027\017\036 )0.5(\r\t\023\024\035\027\036\027\024 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\f\036\022)Tj 0 Tw (-)Tj 0.139 Tw T* [(\r\036\027\026\021\024\030\036 Ne)-17.9(xt)-35(Seq 550 \(Ill)35.1(umina\), \f\024\020\035\026\f\027\024 \023\030\024\021\024\022\024)]TJ 0 Tw (-)Tj 0.173 Tw T* [(\035\031 )0.5(\023\030\024\017\r\024\007\017\021\036\035\016. )0.6(\215\026\021\024\020\036\027\027\024\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.355 0 Td [(\r\036\030\024\016\021\027\024 )0.5(\023\026\021\024\020\036\027)]TJ 0 Tw (-)Tj 0.226 Tw -14.355 -1.218 Td [(\027\024\036 \027\026\004\036\027\017\036, \024\002\027\026\030\031\032\ \036\027\027\t\b )0.5(\r\026\030\017\026\027\021\024\r, \017\031\004\026\035\024\f\034 )]TJ 0.224 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \030\036\022\024\n\036\027\007\026\006\017\005\ CanVIG \(CanVIG-UK Gene )Tj -0.04 Tw T* [(Spec)-24(i\225c R)13(ecommend)42(a)15(t)-32(ions\), \026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \030\036\f\031\030\f\024\r F)10(r)-33(ankl)-30.9(in, )]TJ 0.084 Tw T* [(GnomAD, Br)-31.9(oad Inst)-32(i)-24(tute )0.5(Genomics \017)]TJ /Span<>> BDC ( )Tj EMC [(Spl)-30.9(iceAI L)35(o)-16(okup )]TJ 0 Tw T* [(Br)-32(oad Inst)-31.9(i)-24(tute.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 408.2018 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.792 Tw 10 0 0 10 303.3071 383.8458 Tm [(\215\026\021\024\020\036\027\027\t\036/\r\036\030\024\016\021\027\024 )0.6(\023\026\021\024\020\036\027\027\t\036 )0.5(\r\026\030\017\026\027\021\t )0.6(\020\036)]TJ 0 Tw (-)Tj T* (\027\024\r )Tj /T1_1 1 Tf 1.837 0 Td [(BMP)66(R1A )]TJ /T1_0 1 Tf 3.545 0 Td (\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.87 0 Td (SMAD4 )Tj /T1_0 1 Tf 0.119 Tw 3.043 0 Td (\024\002\027\026\030\031\032\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (18 \017)Tj /Span<>> BDC ( )Tj EMC (28 \f\036\n\036\005 )Tj 0.07 Tw -9.294 -1.218 Td [(\(64,3%\): )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 4.53 0 Td [(7/18 )0.5(\(38,9%\) )0.6(\f\036\n\036\005 )0.5(\023\026\021\024\020\036\027\027\t\005/\r\036\030\024\016\021\027\024 )]TJ ET q /GS0 gs 453.543294 0 0 235.1705969 70.8661499 101.0424769 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \205\200\027\026\020 \030\022\020\b\025\031\024\023\022\007\027\024\n\031\ \b\031 \033\031\022\024\n\020 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC [(\033\031\030\031\016\032\027\025\022\027\026 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC (\024\022\025\030\032\031\026 \005\021\027\025\022\f\017\025\031\b\031 \033\ \031\f\022\033\031\016\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Diagnostic search scheme for patients with 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Finally)42.1(, patient DN)15(A w)12.9(as analyzed by whole-e)-15(xome seq)14(uencing \(WES\), with conf)-43(ir)-14(mation )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(identif)-42.9(ied v)16(ar)-36.9(iants by Sang)12(er seq)14(uencing.)]TJ -0.015 Tw T* [(RESUL)30(T)-10(S: pathog)12(enic and lik)17(ely pathog)12(enic v)16(ar)-37(iants in the)]TJ /Span<>> BDC ( )Tj EMC [(BMP)66(R1A and SMAD4 g)12(enes w)12(ere identif)-43(ied in 18 out of)]TJ /Span<>> BDC ( )Tj EMC (28 )Tj 0.054 Tw T* [(families )0.6(\(64.3%\). )0.5(In )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 10.072 0 Td [(BMP)66(R1A )0.5(g)12(ene, )0.5(11 out )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 9.793 0 Td [(18 )0.5(\(61.1%\) )0.5(g)12(er)-14(mline )0.5(v)16(ar)-36.9(iants )0.5(w)12(ere )0.5(found, )0.5(including three larg)12(e )]TJ 0.07 Tw -19.865 -1.111 Td [(deletions. )0.6(In )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 6.889 0 Td [(SMAD4 )0.6(g)11.9(ene, )0.6(7 )0.5(out )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 8.87 0 Td [(18 )0.5(\(38.9%\) )0.6(g)12(er)-14(mline )0.6(v)16(ar)-37(iants )0.6(w)12(ere )0.6(detected, )0.5(including )0.6(one )0.6(larg)12(e )0.5(deletion )]TJ 0.039 Tw -15.76 -1.111 Td [(and one larg)12(e duplication. Thus, 5 out of)]TJ /Span<>> BDC ( )Tj EMC [(18 \(27.8%\) g)12(er)-13.9(mline v)16(ar)-36.9(iants in these g)11.9(enes w)12(ere larg)12(e rear)-16(rang)12(ements. )]TJ 0.058 Tw T* [(In f)-42.9(iv)13(e families, p)46(reviously unrepor)-40(ted g)12(er)-14(mline v)16(ar)-37(iants w)12(ere identif)-43(ied \(three in BMP)66(R1A and tw)12(o in SMAD4\), all )]TJ 0.023 Tw T* [(classif)-42.9(ied as lik)17.1(ely pathog)12(enic.)]TJ 0.134 Tw T* [(C)21(ON)22(CLUSION: pathog)12(enic and lik)17(ely pathog)12(enic v)16(ar)-37(iants in the)]TJ /Span<>> BDC ( )Tj EMC [(BMP)66(R1A and SMAD4 g)12(enes w)12(ere identif)-43(ied in 18 )]TJ 0.087 Tw T* [(out )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(28 )0.5(families \(64.3%\). )0.5(In )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 14.272 0 Td [(BMP)66(R1A )0.5(g)12(ene, 11 )0.5(out )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(18 )0.5(\(61.1%\) )0.5(g)12(er)-14(mline )0.5(v)16(ar)-37(iants w)12(ere )0.5(found, )0.5(including )]TJ 0.009 Tw -14.272 -1.111 Td [(three larg)12(e deletions. In the)]TJ /Span<>> BDC ( )Tj EMC [(SMAD4 g)12(ene, 7 out of)]TJ /Span<>> BDC ( )Tj EMC [(18 \(38.9%\) g)12(er)-14(mline v)16(ar)-37(iants w)12(ere detected, including one larg)12(e )]TJ 0.038 Tw T* [(deletion and one larg)12(e duplication. In f)-43(iv)13(e families, p)46(reviously unrepor)-39.9(ted g)12(er)-14(mline v)16(ar)-37(iants w)12.1(ere identif)-43(ied \(three )]TJ 0.11 Tw T* [(in BMP)66(R1A and tw)12(o in SMAD4\), all classif)-43(ied as lik)17.1(ely pathog)12(enic. All patients with suspected juv)13(enile polyposis )]TJ 0.074 Tw 0 -1.111 TD [(syndrome should be tested for SMAD4 and BMP)66(R1A mutations using Sang)12(er seq)14(uencing and MLP)45(A. If the)]TJ /Span<>> BDC ( )Tj EMC (result is )Tj 0.091 Tw 0 -1.111 TD [(neg)12(ativ)13(e, high-throughput seq)14(uencing should be em)16(plo)12.1(yed. F)12(or patients with 20 or more adenomatous colorectal )]TJ 0.106 Tw T* [(neoplas)33(ms but no pathog)12.1(enic/lik)17(ely pathog)12.1(enic v)15.9(ar)-36.9(iants in the)]TJ /Span<>> BDC ( )Tj EMC (APC and )Tj 0.01 Tc -0.01 Tw 29.104 0 Td [(MUT)-54(YH)]TJ 0 Tc 0.106 Tw 2.786 0 Td [( g)12(enes, it is advisable to)]TJ /Span<>> BDC ( )Tj EMC [(p)46(roceed )]TJ 0.023 Tw -31.89 -1.111 Td (directly to)Tj /Span<>> BDC ( )Tj EMC [(whole-e)-14.9(xome seq)14(uencing.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 545.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( juv)13(enile polyposis syndrome, SMAD4, BMP)66.1(R1A)12(, DN)15(A diagnostics, MLP)45(A)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.026 Tc -0.043 Tw -9.871 -2.617 Td [(F)3(O)-4.7(R)8.5( )0.6(C)-17.7(I)-15.7(T)45.2(A)37.4(T)-24.6(I)-1.5(ON:)]TJ /T1_2 1 Tf 0.013 Tc -0.035 Tw 6.26 0 Td [( )0.5(V)-20.2(l)-36.9(a)-25.8(s)-10.2(k)-2.9(o)]TJ /Span<>> BDC 2.942 0 Td ( )Tj EMC 0.21 0 Td [(T)53.3(.)-23(A)-22.1(.)-22.7(,)0.6( )0.5(L)-24(o)-17.7(g)-28.1(i)-2.3(n)-11.1(o)-9.5(v)-27.5(a)]TJ /Span<>> BDC 5.954 0 Td ( )Tj EMC 0.21 0 Td [(A)-22.1(.)-1.1(N)-1.9(.)-22.7(,)0.6( )0.5(B)-15.6(a)-9.3(r)-55.6(i)-2.3(n)-11.1(o)-9.5(v)]TJ /Span<>> BDC 5.502 0 Td ( )Tj EMC 0.21 0 Td [(A)-22.1(.)-23.1(A)-22.1(.)-22.7(,)0.6( )0.5(Po)-8.3(n)-11.1(o)-8.4(m)-7.4(a)-9.3(r)-18.3(e)-10.7(n)-7.9(k)-2.8(o)]TJ /Span<>> BDC 7.939 0 Td ( )Tj EMC 0.21 0 Td [(A)-22.1(.)-23.1(A)-22.1(.)-22.7(,)0.6( )0.5(T)42.4(s)-7.9(u)-8.8(k)-23.3(a)-6.8(n)-11(o)-9.5(v)]TJ /Span<>> BDC 6.119 0 Td ( )Tj EMC 0.21 0 Td [(A)-22.2(.)-26(S)-8.8(.)0.6( )0.5(M)-9.3(o)-14.8(l)-22.9(e)-18.2(c)-11.3(u)-7.5(l)-37(a)-9.3(r)0.5( )0.5(g)-13.5(e)-10.7(n)-15.2(e)-21.5(t)-45.3(i)-4.2(c)0.6( )0.5(t)-23.9(e)-21.9(s)-28.5(t)-45.3(i)-2.4(n)-11(g)0.5( )0.5(o)-11.2(f)0.5( )0.5(r)-29.4(u)-21.1(s)-21.4(s)-25.3(i)-4.2(a)-6.8(n)0.6( )0.5(p)-19.2(a)-17.3(t)-45.4(i)-10.1(e)-10.7(n)-16.4(t)-48.1(s)13( )]TJ 0.01 Tc -35.774 -1.2 Td [(w)-44.9(i)-15.1(t)-25.3(h)0.5( s)-8.1(u)-21.1(s)-8.5(p)-24(e)-18.3(c)-40.8(t)-23.9(e)-20.2(d j)-2.7(u)-14.1(v)-17.9(e)-10.8(n)-13.2(i)-6.4(l)-22.9(e)0.5( p)-21.6(o)-14.8(l)-7.5(y)-30.1(p)-21.5(o)-15.1(s)-25.3(i)-6.6(s )0.5(s)-30.1(y)-26.7(n)-13.8(d)-9.6(r)-15(o)-8.5(m)-15.8(e)-6.2(.)0.5( )]TJ /T1_0 1 Tf 0.016 Tc -0.016 Tw [(K)10.7(o)-3.3(lo)-3.4(p)-0.8(rok)-22.5(t)-1(o)-3.3(lo)-6.5(g)-16.5(i)3.5(a)2.6(.)]TJ /T1_2 1 Tf -0.001 Tc -0.024 Tw 25.781 0 Td [( 2)-19.1(0)-14.1(2)-6(6)9.6(;2)-11.6(5)-9.4(\()27.5(1)34(\))4.3(:)10.6(1)-10.2(2\226)40.5(1)-12.6(8)-21.4(.)-10.5( \()-11.1(i)-13.5(n)-10.5( R)-16.8(u)-32.1(s)-32.5(s)-25.8(.)33(\).)-10.6( )0.5(h)-27.5(t)-59.6(t)-39.7(p)-28.9(s)-18.2(:)-8.4(/)74.5(/)26.2(d)-21.4(o)-22.7(i)-10.5(.)-7.5(o)-22.1(r)-26.9(g)-33(/)0.9(1)3.8(0)-3.8(.)-15.8(3)-2.3(3)-26.2(8)-8.9(7)-5.7(8)-10.2(/)-2.3(2)-19.2(0)-0.9(7)-12.2(3)-23.5(-)30.9(7)0.5(5)-9.9(5)-19.1(6)-37(-2)-19.1(0)-14.1(2)-6(6)-37(-)]TJ -0.032 Tc 0.032 Tw -25.781 -1.2 Td [(2)-56.4(5)-78.5(-1)-28.1(-1)-55(2)-42.9(-1)-57.4(8)]TJ /T1_1 1 Tf 0.01 Tc 0.143 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.148 Tw 10.827 0 Td ( \211\f\020\024\n\031 .A., \214\216\221\210 \253\001\215\002\037 \n\031\ \f\031\033\032\031\n\023\031\f\031\b\022\022 \022\026\027\025\022 \003.\001\ .)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 \003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.832 -1.2 Td (\215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: ta.vlask\ o@yandex.ru)Tj /T1_1 1 Tf 0.01 Tc 0.149 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.154 Tw 14.312 0 Td [( Vlask)13(o T)63.1(.A., Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46(roctology)42.1(, Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.317 -1.2 Td [(123423, R)22(ussia; e-mail: ta.vlask)13(o@yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 28.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 28.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 371.6679 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.311 Tw 10 0 0 10 42.5197 347.3119 Tm (\222\017\027\007\030\024\n \033\r\036\027\017\035\034\027\024\020\024 \023\ \024\035\017\023\024\026 \(\222\224\215\))Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\007\022\024\036 )Tj 0.342 Tw 0 -1.218 TD (\026\002\024\035\036\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\026\031\021\024\f\024\n\027\024-\007\024\n\017\027\026\027\021\027\t\n \ \021\017\023\024\n \027\026)Tj 0 Tw (-)Tj 0.761 Tw T* (\f\035\036\007\024\r\026\027\017\016, \022\024\021\024\030\024\036 \b\026\ \030\026\022\021\036\030\017\031\036\021\f\016 \027\026\035\017\004\017\ \036\n )Tj 0.171 Tw T* (\n\027\024\032\036\f\021\r\036\027\027\t\b \033\r\036\027\017\035\034\027\ \t\b \023\024\035\017\023\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\024\004\027\024)Tj /Span<>> BDC ( )Tj EMC 21.758 0 Td (-)Tj 0 Tw -21.758 -1.218 Td (\022\017\001\036\004\027\024\n \021\030\026\022\021\036 [1].)Tj -0.025 Tw T* [(\212\017\026\020\027\024 )0.5(\031\f\021\026\027\026\r\035\017\r\026\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 )0.5(\024\007\027\024\020\024 \017)]TJ /Span<>> BDC ( )Tj EMC 20.304 0 Td (\022\035\017)Tj 0 Tw (-)Tj 0.22 Tw -20.304 -1.218 Td [(\027\017\004\036\f\022\017\b )0.5(\022\030\017\021\036\030\017\036\r \(5 )0.5(\017\035\017 \002\024\035\036\036 )0.5(\033\r\036\027\017\035\034\027\t\b )0.5(\023\024)]TJ 0 Tw (-)Tj 0.417 Tw T* [(\035\017\023\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.241 0 Td [(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\036, )0.5(\027\026\035\017\004\017\036 )0.6(\n\027\024\032\036\f\021\r\036\027\027\t\b )]TJ 0.047 Tw -4.241 -1.218 Td (\033\r\036\027\017\035\034\027\t\b \023\024\035\017\023\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 \r\f\036\020\024 \032\036\035\031\ \007\024\004)Tj 0 Tw (-)Tj 0.02 Tw T* [(\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026, \ )0.5(\035\033\002\024\036 \022\024\035\017\004\036\f\021\r\024 )0.5(\033\r\036\027\017\035\034\027\t\b )]TJ 0.106 Tw T* (\023\024\035\017\023\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \007\026\027\027\024\020\024 \007\017\026\020\ \027\024\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\024\n )Tj 0.175 Tw T* (\026\027\026\n\027\036\036\) \017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\036\ \f\022\024\n )0.6(\023\024\007)]TJ 0 Tw (-)Tj T* (\021\r\036\030\032\007\036\027\017\017 \026\002\024\035\036\r\026\027\017\ \016 [1].)Tj 0.02 Tc 0.076 Tw T* (\211 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\033\r\036\027\017\035\034\027\t\n \023\024\035\017\023\024\024\n \022\024\ \035\017\004\036\f\021\r\024)20( )]TJ 0.081 Tw T* (\023\024\035\017\023\024\r \n\024\032\036\021 \r\026\030\034\017\030\024\ \r\026\021\034 \024\021 5 \007\024)Tj /Span<>> BDC ( )Tj EMC (200, \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n)20( )]TJ -0.001 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036, \023\024\n\017\n\024 \033\ \r\036\027\017\035\034\027\t\b, \n\024\020\031\021 \r\f\021\030\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.483 Tw T* (\004\026\021\034\f\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\026\007\036\027\024\n\026\021\024\027\t\036 \027\024\r\024\024\002\030\ \026\024\r\026\027\017\016, \004\021\024)20( )]TJ 0.145 Tw T* [(\027\026\004\017\021\036\035\034\027\024 )0.5(\026\021\030\031\007\027\016\036\021 \007\017\026\020\027\024\f\021\017\ \022\031 )0.5(\026\002\024\035\036\r\026\027\017\016)20( )]TJ 0.309 Tw T* [([2]. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 3.305 0 Td [(\035\017\021\036\030\026\021\031\030\036 )0.5(\024\023\017\f\026\027\t )0.5(\022\035\017\027\017\004\036\f\022\017\036 )0.5(\f\035\031\004\026\017,)20( )]TJ 0.345 Tw -3.305 -1.218 Td (\022\024\020\007\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\017 \023\024\007\021\r\036\030\032\ \007\036\027)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.017 Tw T* [(\027\t\n \007\017\026\020\027\024\024\n \033\r\036\027\017\035\034\027\024\ \020\024 \023\024\035\017\023\024\026 \r\t\016\r\035\016\035\017\f\034)20( )]TJ 0.305 Tw T* [(\021\024\035\034\022\024 )0.5(\026\007\036\027\024\n\026\021\024\027\t\036 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 )0.5(\021\024\035\f\021\024\005)20( )]TJ 0 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC ([3].)Tj 0 Tc 0.323 Tw 23.244 29.227 Td (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \212\ \203\025-\007\017\026\020\027\024\f\021\017\022\026 \023\024\r\024\035\016\ \036\021 )Tj 0.077 Tw T* (\027\026\005\021\017 \020\036\027\036\021\017\004\036\f\022\031\033 \023\ \030\017\004\017\027\031 \026\002\024\035\036\r\026\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (40\22660% )Tj 0.44 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\222\224\215, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\002\027\026\030\031\032\017\r\026\033\021 \ \023\026)Tj 0 Tw (-)Tj 0.444 Tw T* (\021\024\020\036\027\027\t\036 \(\r\036\030\024\016\021\027\024 \023\026\ \021\024\020\036\027\027\t\036\) \r\026\030\017\026\027\021\t \020\036\027\ \024\r )Tj /T1_0 1 Tf 0 Tw T* (SMAD4 )Tj /T1_2 1 Tf 0.237 Tw 3.161 0 Td (\(NM_005359.6; OMIM #600993\) \017\035\017 )Tj /T1_0 1 Tf 0 Tw [(BMP)66(R1A )]TJ /T1_2 1 Tf 0.752 Tw -3.161 -1.218 Td (\(NM_004329.3; OMIM #601299\))Tj /T1_0 1 Tf 0 Tw (,)Tj /T1_2 1 Tf 0.752 Tw ( \030\026\f\023\024\035\024\032\036\027\027\t\b )Tj 0.281 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\n\024\f\024\n\026\b 18q21 \017)Tj /Span<>> BDC ( )Tj EMC (10q22, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 [4]. )Tj 0.238 Tw T* [(\215\030\017\n\036\030\027\024 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.587 0 Td [(20\22630% )0.5(\027\026\002\035\033\007\036\027\017\005 )0.5(\222\224\215 )0.6(\024\002\031\f\035\024\r\035\036\027 )]TJ 0.858 Tw -5.587 -1.218 Td (\023\026\021\024\020\036\027\027\t\n\017/\r\036\030\024\016\021\027\024 \ \023\026\021\024\020\036\027\027\t\n\017 \r\026\030\017\026\027\021\026\n\ \017 )Tj 0 Tw T* (\020\036\027\026 )Tj /T1_0 1 Tf 2.143 0 Td [(BMP)66(R1A, )]TJ /T1_2 1 Tf 0.099 Tw 3.729 0 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\r 20\22630%)Tj /Span<>> BDC ( )Tj EMC (\227 \023\026\021\024\020\036\027\027\t\n\017/\r\036\030\024\016\021\027\ \024 )Tj 0.178 Tw -5.872 -1.218 Td (\023\026\021\024\020\036\027\027\t\n\017 \r\026\030\017\026\027\021\026\n\ \017 \020\036\027\026 )Tj /T1_0 1 Tf 0 Tw (SMAD4 )Tj /T1_2 1 Tf 16.416 0 Td ([4].)Tj /T1_0 1 Tf ( )Tj /T1_2 1 Tf 0.178 Tw 1.947 0 Td (\210\002\026 \020\036\027\026 )Tj -0.068 Tw -18.363 -1.218 Td (\016\r\035\016\033\021\f\016 \f\031\023\030\036\f\f\024\030\026\n\017 \024\ \023\031\b\024\035\036\r\024\020\024 \030\024\f\021\026, \031\004\026\f\021\ \r\031\033\021 )Tj 0.009 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\027\026\035\034\027\t\b \023\031\021\016\b \022\024\f\021\027\ \t\b \n\024\030\235\024\020\036\027\036\021\017\004\036\f\022\017\b \002\ \036\035)Tj 0 Tw (-)Tj 0.016 Tw T* (\022\024\r \()Tj /T1_0 1 Tf 0 Tw (BMP)Tj /T1_2 1 Tf 0.016 Tw (\) \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\235\024\030\n\017\030\031\033\013\036\020\024 \235\026\ \022\021\024\030\026 \030\024\f\021\026 \002\036\021\026 )Tj 0 Tw T* (\()Tj /T1_0 1 Tf [(T)18(GF-\223\), )]TJ /T1_2 1 Tf 0.085 Tw 3.543 0 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\r\035\017\016\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\036 \022\035\036\021\024\004\027\t\036 \023\030\024\006\ \036\f\f\t, \022\026\022 )Tj 0.088 Tw -3.543 -1.218 Td [(\030\024\f\021, )0.5(\007\017\235\235\036\030\036\027\006\017\030\024\r\022\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.201 0 Td [(\026\023\024\023\021\024 )0.6([5])]TJ /T1_0 1 Tf 0 Tw (. )Tj /T1_2 1 Tf 5.449 0 Td (\207\024\035\034\001\017\027\f\021\r\024 )Tj 0.02 Tw -16.65 -1.218 Td (\023\026\021\024\020\036\027\027\t\b \r\026\030\017\026\027\021\024\r \023\ \030\036\007\f\021\026\r\035\016\033\021 \f\024\002\024\005 \021\024\004\ \022\024\r\t\036 )Tj -0.008 Tw T* [(\n\031\021\026\006\017\017 )0.5(\017\035\017 )0.6(\027\036\002\024\035\034\001\017\036 )0.5(\007\036\035\036\006\017\017/\r\f\021\026\r\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.162 0 Td (\022\024\007\017\030\031\033)Tj 0 Tw (-)Tj -0.009 Tw -18.162 -1.218 Td (\013\017\b \024\002\035\026\f\021\016\b, \024\007\027\026\022\024 \024\022\ \024\035\024 15% \r\026\030\017\026\027\021\024\r \016\r\035\016\033\021\ \f\016 )Tj -0.047 Tw T* (\023\030\024\021\016\032\036\027\027\t\n\017 \023\036\030\036\f\021\030\024\ \005\022\026\n\017 [5,6])Tj /T1_0 1 Tf 0 Tw (. )Tj /T1_2 1 Tf 15.272 0 Td (\215\030\017\002\035\017\017\021\036\035\034\027\024 )Tj 0.295 Tw -15.272 -1.218 Td [(20\22650% )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 9.656 0 Td [(\f\017\027\007\030\024\n\024\n )0.5(\033\r\036\027\017\035\034\027\024\020\024 )0.6(\023\024)]TJ 0 Tw (-)Tj 0.146 Tw -9.656 -1.218 Td [(\035\017\023\024\026 )0.5(\027\036 \017\n\036\033\021 \f\036\n\036\005\027\024\020\024 )0.5(\026\027\026\n\027\036\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\002\031\f\035\024\r\035\036)Tj 0 Tw (-)Tj 0.154 Tw T* [(\027\t )0.5(\n\031\021\026\006\017\016\n\017 )]TJ /T1_0 1 Tf 6.346 0 Td [(de )0.5(nov)13(o)]TJ /T1_2 1 Tf [( )0.5([5\2267])]TJ /T1_0 1 Tf 0 Tw (. )Tj /T1_2 1 Tf 0.154 Tw 6.535 0 Td (\203\026)Tj /Span<>> BDC ( )Tj EMC 1.46 0 Td [(\f\036\020\024\007\027\016\001\027\017\005 )0.6(\007\036\027\034 )]TJ 0.388 Tw -14.342 -1.218 Td [(\007\035\016 )0.5(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC 8.063 0 Td [(\023\024\007\024\030\036\027\017\036\n )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\222\224\215 )0.5(\007\024\f\021\031\023\027\t )]TJ 0.756 Tw -8.063 -1.218 Td (\030\026\035\017\004\027\t\036 \f\021\030\026\021\036\020\017\017 \n\024\ \035\036\022\031\035\016\030\027\024-\020\036\027\036\021\017\004\036\f\022\ \024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\025\020\004\r\002\020\213\005\t\025-\013)10(\004\t\004\026\n\225\004\016\r)10.1(\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004 \005\025\016\016\n\221\016\r\n\220 \224\017\ \n\004\t\026)11(\025\b )]TJ 0 -1 TD [(\016\022\224\025\202\025)21(\212\005\004\t\n\004\024 \t\017\022\016\n\t\202\005\025\024\022\206\b\004\ \t\n\020\200\t\025\013)10(\025\022\224\025\020\n\224\025)21(\212\017)]TJ 43.152 1 Td [(Molecular genetic testing of r)10(ussian patients )]TJ 0.199 -1 Td [(with\022suspected ju)10.1(v)11.9(enile polyposis s)10(yndr)20(ome)]TJ -43.351 96.622 Td [(\001\032)50(\f)42(\032\214\027 \007\036)30.1(\235\240\033)30(\f)]TJ 52.896 0 Td (LEADING ARTICLE)Tj /T1_5 1 Tf 25 0 0 25 511.9769 56.0378 Tm (13)Tj ET endstream endobj 1749 0 obj [1759 0 R] endobj 1750 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 285.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 285.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 247.8024 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 247.8024 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-12-18)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 131.1593 695.3259 Tm [(\235\025\020\004\r\002\020\213\005\t\025-\013)10.1(\004\t\004\026\n\225\004\016\r)10.1(\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004 )]TJ 0.843 -1.105 Td [(\005\025\016\016\n\221\016\r\n\220 \224\017\n\004\t\026)11.1(\025\b \016\022)-23.3(\224\025\202\025)21(\212\005\004\t\n\004\024 )]TJ 0 Tw 0.579 -1.105 Td [(\t\017\022)-23.3(\016\n\t\202\005\025\024\022)-23.3(\206\b\004\t\n\020\200\t\025\013)10.1(\025\022)-23.3(\224\025\020\n\224\025)21(\212\017)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw 14 0 0 14 70.8661 628.822 Tm [(\021\020\017\016\r)10(\025\022)-23.2(\032.\f)-31(., \035\025\013\n\t\025\b\017\022)-23.2(\f)-31(.\007., \006\017\005\n\t\025\b\022)-23.2(\f)-31(.\f)-31(., \034\025\t\025\024\017\005\004\t\r)10.1(\025\022)-23.3(\f)-31(.\f)-31(., )]TJ 0 Tw 0 -1.143 TD [(\003\002\r\017\t\025\b\022)-23.2(\f)-31(.\001.)]TJ 0.023 Tw 10 0 0 10 70.8661 595.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.2(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ 0 -1.2 TD [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.109 Tw 9 0 0 9 119.0551 564.6488 Tm [(\037\036\035\034: )0.6(\033\032\031\030\027\026\031\025\024\023\032\022\032\031\021\020\023\017\ )0.7(\032\027\016\r\f\017\023\020\023\013 )0.6(\026\031\f\027\n\r\f\t\032\025\031-\b\027\025\027\023\022\007\027\024\n\031\ \b\031 )0.6(\022\024\024\f\027\030\031\021\020\025\022\t )0.6(\033\020\006\022\027\025\023\031\021 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 41.457 0 Td (\033\031\030\031\016\032\027)Tj 0 Tw (-)Tj 0.023 Tw -41.457 -1.111 Td (\025\022\027\026 \025\020)Tj /Span<>> BDC ( )Tj EMC (\024\022\025\030\032\031\026 \005\021\027\025\022\f\017\025\031\b\031 \033\ \031\f\022\033\031\016\020.)Tj 0.203 Tw 0 -1.111 TD (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \026\031\f\027\n\r\f\t\032\025\031-\b\027\025\027\ \023\022\007\027\024\n\031\027 \022\024\024\f\027\030\031\021\020\025\022\ \027 \033\032\031\021\027\030\027\025\031 \r)Tj /Span<>> BDC ( )Tj EMC (30 \033\020\006\022\027\025\023\031\021 \022\016)Tj /Span<>> BDC ( )Tj EMC (28 \024\027\026\027\235 )Tj 0.148 Tw T* (\(\021 \031\030\025\031\235 \024\027\026\017\027 \240\013\f\031 \024\032\ \020\016\r 3 \033\031\032\020\255\027\025\025\013\200 \032\031\030\024\023\ \021\027\025\025\022\n\020\), \n\031\023\031\032\013\027 \025\020\240\f\005\ \030\020\f\022\024\017 \024)Tj /Span<>> BDC ( )Tj EMC (2012 \033\031)Tj /Span<>> BDC ( )Tj EMC (2024 \b\b. \220\001\202 )Tj 0.169 Tw T* [(\021\013\030\027\f\t\f\022 )0.6(\022\016)]TJ /Span<>> BDC ( )Tj EMC 5.683 0 Td [(\f\027\235\n\031\006\022\023\031\021 )0.6(\033\027\032\022\203\027\032\022\007\027\024\n\031\235 )0.6(\n\032\031\021\022 )0.5(\033\020\006\022\027\025\023\031\021. )0.6(\004\027\032\021\013\026 )0.6(\204\023\020\033\031\026 )0.5(\024\027\n\021\027\025\022\032\031\021\020\f\022 )0.5(\b\027\025\013 )0.5(SMAD4 )]TJ 0.178 Tw -5.683 -1.111 Td (\(NM_005359.6\) \022)Tj /Span<>> BDC ( )Tj EMC [(BMPR1A \(NM_004329.3\) )0.5(\026\027\023\031\030\031\026 \205\204\025\b\027\032\020, )0.5(\030\020\f\027\027 \033\032\031\021\031\030\022\f\022 \033\031\022\024\n\ )0.5(\n\032\r\033\025\013\200 \033\027\032\027\024\023\032\031\027\n )]TJ 0.058 Tw T* (\026\027\023\031\030\031\026 MLPA. \004\031\024\f\027\030\025\022\026 \204\ \023\020\033\031\026 \220\001\202 \033\020\006\022\027\025\023\031\021 \022\ \024\024\f\027\030\031\021\020\f\022 \026\027\023\031\030\031\026 \033\031\ \f\025\031\204\n\016\031\026\025\031\b\031 \024\027\n\021\027\025\022\032\ \031\021\020\025\022\t, )Tj 0.023 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\033\031\030\023\021\027\032\255\030\027\025\022\027\026 \021\013\t\021\f\ \027\025\025\013\200 \021\020\032\022\020\025\023\031\021 \026\027\023\031\ \030\031\026 \024\027\n\021\027\025\022\032\031\021\020\025\022\t \033\031\ )Tj /Span<>> BDC ( )Tj EMC (\205\204\025\b\027\032\r.)Tj 0.028 Tw T* (\206\036\207\210\035\034\003\201: \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\031\f\027\n\r\f\t\032\025\031-\b\027\025\027\023\022\007\027\024\n\031\ \026 \022\024\024\f\027\030\031\021\020\025\022\022 \033\020\023\031\b\027\ \025\025\013\027 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\032\031\t\023\025\031 \033\020\023\031\b\027\025\025\013\027 \021\ \020\032\022\020\025\023\013 )Tj 0.096 Tw T* (\b\027\025\031\021 BMPR1A \022)Tj /Span<>> BDC ( )Tj EMC (SMAD4 \240\013\f\022 \031\240\025\020\032\r\255\027\025\013 \021)Tj /Span<>> BDC ( )Tj EMC (18/28 \024\027\026\027\235 \(64,3%\). \211)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 BMPR1A \021\013\t\021\f\027\025\031 11/18 \(61,1%\) )Tj 0.111 Tw T* (\025\020\024\f\027\030\024\023\021\027\025\025\013\200 \021\020\032\022\020\ \025\023\031\021, \022\016)Tj /Span<>> BDC ( )Tj EMC (\n\031\023\031\032\013\200 3 \n\032\r\033\025\013\027 \030\027\f\027\006\ \022\022, \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 SMAD4)Tj /Span<>> BDC ( )Tj EMC (\227 7/18 \(38,9%\) \025\020\024\f\027\030\024\023\021\027\025)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.111 TD (\025\013\200 \021\020\032\022\020\025\023\031\021, \024\032\027\030\022 \ \025\022\200 1 \n\032\r\033\025\020\t \030\027\f\027\006\022\t \022)Tj /Span<>> BDC ( )Tj EMC (1 \n\032\r\033\025\020\t \030\r\033\f\022\n\020\006\022\t. \020\n\022\026\ \031\240\032\020\016\031\026, \024\032\020\016\r 5/18 \(27,8%\) )Tj -0.005 Tw 0 -1.111 TD (\025\020\024\f\027\030\024\023\021\027\025\025\013\200 \021\020\032\022\020\ \025\023\031\021 \030\020\025\025\013\200 \b\027\025\031\021 \t\021\f\t\005\ \023\024\t \n\032\r\033\025\013\026\022 \033\027\032\027\024\023\032\031\ \235\n\020\026\022. \211)Tj /Span<>> BDC ( )Tj EMC (5 \024\027\026\017\t\200 \025\020\235\030\027\025\013 \032\020\025\027\027\ \025\027 )Tj 0.004 Tw T* (\031\033\022\024\020\025\025\013\027 \021)Tj /Span<>> BDC ( )Tj EMC (\026\022\032\027 \b\027\032\026\022\025\020\f\017\025\013\027 \021\020\032\ \022\020\025\023\013 \(3)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 BMPR1A, \022)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 SMAD4\), \030\f\t \021\024\027\200 \r\024\023\020\025\031\ \021\f\027\025\031 )Tj 0.023 Tw T* (\021\027\032\031\t\023\025\031 \033\020\023\031\b\027\025\025\031\027 \016\ \025\020\007\027\025\022\027.)Tj 0.211 Tw T* (\211\201\211\217\220\201: \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\031\f\027\n\r\f\t\032\025\031-\b\027\025\027\023\022\007\027\024\n\031\ \026 \022\024\024\f\027\030\031\021\020\025\022\022 \033\020\023\031\b\027\ \025\025\013\027 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\032\031\t\023\025\031 \033\020\023\031\b\027\025\025\013\027 \021\ \020\032\022\020\025\023\013 )Tj 0.096 Tw T* (\b\027\025\031\021 BMPR1A \022)Tj /Span<>> BDC ( )Tj EMC (SMAD4 \240\013\f\022 \031\240\025\020\032\r\255\027\025\013 \021)Tj /Span<>> BDC ( )Tj EMC (18/28 \024\027\026\027\235 \(64,3%\). \211)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 BMPR1A \021\013\t\021\f\027\025\031 11/18 \(61,1%\) )Tj 0.196 Tw T* (\025\020\024\f\027\030\024\023\021\027\025\025\013\200 \021\020\032\022\020\ \025\023\031\021, \022\016)Tj /Span<>> BDC ( )Tj EMC (\n\031\023\031\032\013\200 3)Tj /Span<>> BDC ( )Tj EMC (\227 \n\032\r\033\025\013\027 \030\027\f\027\006\022\022, \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 SMAD4)Tj /Span<>> BDC ( )Tj EMC (\227 7/18 \(38,9%\) \025\020\024\f\027\030)Tj 0 Tw (-)Tj 0.096 Tw T* (\024\023\021\027\025\025\013\200 \021\020\032\022\020\025\023\031\021, \024\ \032\027\030\022 \025\022\200 1 \n\032\r\033\025\020\t \030\027\f\027\006\ \022\t \022)Tj /Span<>> BDC ( )Tj EMC (1 \n\032\r\033\025\020\t \030\r\033\f\022\n\020\006\022\t. \211)Tj /Span<>> BDC ( )Tj EMC (5 \024\027\026\017\t\200 \025\020\235\030\027\025\013 \032\020\025\027\027\ \025\027 )Tj 0.004 Tw T* (\031\033\022\024\020\025\025\013\027 \021)Tj /Span<>> BDC ( )Tj EMC (\026\022\032\027 \b\027\032\026\022\025\020\f\017\025\013\027 \021\020\032\ \022\020\025\023\013 \(3)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 BMPR1A, \022)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\027 SMAD4\), \030\f\t \021\024\027\200 \r\024\023\020\025\031\ \021\f\027\025\031 )Tj 0.041 Tw 0 -1.111 TD (\021\027\032\031\t\023\025\031 \033\020\023\031\b\027\025\025\031\027 \016\ \025\020\007\027\025\022\027. \211\024\027\026 \033\020\006\022\027\025\023\ \020\026 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\030\031\016\032\027\025\022\027\026 \025\020)Tj /Span<>> BDC ( )Tj EMC (\024\022\025\030\032\031\026 \005\021\027\025\022\f\017\025\031\b\031 \033\ \031\f\022\033\031\016\020 \025\027\031\240\200\031)Tj 0 Tw (-)Tj 0.011 Tw 0 -1.111 TD (\030\022\026\031 \022\024\024\f\027\030\031\021\020\025\022\027 \b\027\025\ \031\021 SMAD4 \022)Tj /Span<>> BDC ( )Tj EMC (BMPR1A \026\027\023\031\030\020\026\022 \024\027\n\021\027\025\022\032\031\ \021\020\025\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (\205\204\025\b\027\032\r \022)Tj /Span<>> BDC ( )Tj EMC (MLPA, \020)Tj /Span<>> BDC ( )Tj EMC (\033\032\022 \031\023\032\022\006\020\023\027\f\017)Tj 0 Tw (-)Tj 0.046 Tw T* (\025\031\026 \032\027\016\r\f\017\023\020\023\027)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC [(\033\031\026\031\212\017\005 \026\027\023\031\030\020 \021\013\024\031\n\ \031\033\032\031\022\016\021\031\030\022\023\027\f\017\025\031\b\031 )0.6(\024\027\n\021\027\025\022\032\031\021\020\025\022\t; \240\031\f\017\025\ \013\026 \024)]TJ /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\027\026 20 )Tj 0.02 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\027\027 \020\030\027\025\031\026\020\023\031\016\025\013\200 \ \025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\031\f\024\ \023\031\235 \n\022\213\n\022, \025\031 \024)Tj /Span<>> BDC ( )Tj EMC (\031\023\024\r\023\024\023\021\022\027\026 \033\020\023\031\b\027\025\025\ \013\200/\021\027\032\031\t\023\025\031 \033\020\023\031)Tj 0 Tw (-)Tj 0.023 Tw T* (\b\027\025\025\013\200 \021\020\032\022\020\025\023\031\021 \021)Tj /Span<>> BDC ( )Tj EMC (\b\027\025\020\200 APC \022)Tj /Span<>> BDC ( )Tj EMC 0.01 Tc -0.01 Tw 13.687 0 Td (MUTYH)Tj 0 Tc 0.023 Tw 2.732 0 Td (, \006\027\f\027\024\031\031\240\032\020\016\025\031 \024\032\020\016\r \ \021\013\033\031\f\025\t\023\017 \033\031\f\025\031\204\n\016\031\026\025\ \031\027 \024\027\n\021\027\025\022\032\031\021\020\025\022\027.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 309.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \024\022\025\030\032\031\026 \005\021\027\025\022\f\017\025\031\b\031 \033\ \031\f\022\033\031\016\020, SMAD4, BMPR1A, \220\001\202-\030\022\020\b\025\ \031\024\023\022\n\020, MLPA)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.033 Tc -0.021 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc -0.016 Tw 9.151 0 Td ( \200\035\026\f\022\024)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \214\024\020\017\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \207\026\030\017\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \215\024\027\024\n\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \037\031\022\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\222. \204\024\035\036\022\031\035\016\030\027\024-\020\036\027\036\ \021\017\004\036\f\022\024\036 \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.039 Tw -9.156 -1.2 Td (\007\024\r\026\027\017\036 \030\024\f\f\017\005\f\022\017\b \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024\030\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n \033\r\036\027\017\035\034\027\024\020\024 \023\ \024\035\017\023\024\026. )Tj /T1_0 1 Tf -0.023 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.039 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(12\22618.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2026-25-1-12-18)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 140.7041 221.6331 Tm [(Molecular genetic testing of r)10.1(ussian patients )]TJ 0.111 -1.167 Td [(with\022)-23.2(suspected ju)10(v)12(enile polyposis s)10(yndr)20(ome)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 176.1292 Tm [(T)40(atiana\022)-23.2(A)-31(.\022)-23.3(Vlask)11(o, Anna\022)-23.3(N.\022)-23.3(Loginov)10.1(a, Ale)21(x)10(ey\022)-23.3(A)-30.9(.\022)-23.3(Barinov)21(, )]TJ 0 -1.143 TD [(Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(P)10(onomar)31(enk)11(o, Ale)21(x)10(ey\022)-23.3(S.\022)-23.3(T)40(sukanov)]TJ 10 0 0 10 70.8661 142.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ /T1_0 1 Tf 0.143 Tw 9 0 0 9 119.0551 123.956 Tm (AIM: to)Tj /Span<>> BDC ( )Tj EMC [(p)46(resent the)]TJ /Span<>> BDC ( )Tj EMC (results of)Tj /Span<>> BDC ( )Tj EMC [(molecular g)12(enetic testing in patients with suspected juv)13(enile polyposis syndrome )]TJ 0 Tw 0 -1.111 TD (\(JPS\).)Tj 0.176 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: molecular g)11.9(enetic testing w)13(as per)-34(for)-13.9(med on 30 patients from 28 families \(one fam)]TJ 0 Tw (-)Tj 0.108 Tw T* [(ily )0.5(had )0.5(three )0.5(af)-40(fected )0.5(relativ)13(es\) )0.5(who )0.5(w)12(ere )0.5(follow)12(ed )0.5(from )0.5(2012 )0.5(to)]TJ /Span<>> BDC ( )Tj EMC 26.504 0 Td [(2024. )0.5(DN)15(A )0.5(w)13(as )0.5(isolated )0.5(from )0.5(patients)33(\222 per)-37(iph)]TJ 0 Tw (-)Tj 0.17 Tw -26.504 -1.111 Td [(eral blood leuk)13(ocytes. The)]TJ /Span<>> BDC ( )Tj EMC [(initial step in)11(v)13(olv)13(ed Sang)12(er seq)14(uencing of)]TJ /Span<>> BDC ( )Tj EMC [(the SMAD4 \(NM_005359.6\) and BMP)66(R1A )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 573.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 564.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 132.4604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 123.5332 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 837.3533 Tm [(\017)-32(\r)41(\037)31(\r\230\231)5( \t\004\213\207\n)43(\037)]TJ /T1_1 1 Tf 0 -1.605 TD [(LEADING)5( ARTICLE)]TJ ET Q BT 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\001\032)50(\f)42(\032\214\027 \007\036)30.1(\235\240\033)30(\f)]TJ 52.896 0 Td (LEADING ARTICLE)Tj -52.896 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 27.2651 56.0378 Tm (12)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 423.2177 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 427.0585 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 430.1 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 0.855 2.481 0.972 2.358 c 1.09 2.234 1.181 2.087 1.237 1.925 c 1.355 1.567 1.355 1.18 1.237 0.82 c 1.181 0.659 1.09 0.512 0.972 0.388 c 0.855 0.266 0.713 0.169 0.558 0.106 c 0.38 0.034 0.191 -0.002 0 0 c 0 0.454 m 0.115 0.451 0.23 0.479 0.332 0.534 c 0.424 0.586 0.502 0.659 0.562 0.746 c 0.624 0.836 0.669 0.936 0.695 1.041 c 0.752 1.26 0.752 1.491 0.695 1.71 c 0.669 1.816 0.625 1.916 0.562 2.005 c 0.502 2.091 0.423 2.163 0.332 2.215 c 0.123 2.323 -0.126 2.323 -0.335 2.215 c -0.427 2.163 -0.505 2.091 -0.566 2.005 c -0.628 1.916 -0.673 1.816 -0.699 1.71 c -0.756 1.491 -0.756 1.26 -0.699 1.041 c -0.672 0.936 -0.627 0.836 -0.566 0.746 c -0.506 0.659 -0.427 0.586 -0.335 0.534 c -0.232 0.478 -0.117 0.451 0 0.454 c f Q q 1 0 0 1 431.8979 732.5762 cm 0 0 m 0.531 0 l 0.531 -0.505 l 0.55 -0.43 0.583 -0.359 0.629 -0.297 c 0.681 -0.229 0.74 -0.167 0.807 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r)-27(e)-27(c)-48.6(t)-30.2(u)-15.2(m)-36(, a)-16(n)-15.9(u)-29.6(s)-45.3(, p)-32.4(e)-25.8(l)-13.8(v)-58.6(i)-13.3(c )]TJ 0.023 Tw T* [(f)-54.1(l)-28.8(o)-26.5(o)-20(r a)-15.8(n)-22.5(d p)-32.4(e)-20.2(r)-63.1(i)-11.6(n)-24(e)-22.1(u)-15.2(m)-14.4(.)]TJ 0.017 Tc 0.623 Tw T* [(T)-25.7(h)-23.2(e j)-15.2(o)-21.4(u)-16(r)-43.4(n)-16.2(a)-19.7(l )]TJ /T1_4 1 Tf 0.031 Tc -0.031 Tw [(K)10.2(o)-3.4(lo)-3.5(p)-1(rok)-22(t)-1.2(o)-3.4(lo)-6.6(g)-16.1(i)3(a)]TJ /T1_3 1 Tf 0.041 Tc 0.599 Tw 13.105 0 Td [( \()19(R)9.1(u)-5.8(s)-6.3(s)-9.8(i)10.5(a)8(n)23.9( J)5.8(o)2.6(u)8(r)-19.4(n)7.8(a)4.4(l)23.9( o)3.7(f)23.9( Col)-4.9(o)7.4(p)2.1(ro)-0.8(c)-24.7(t)-5.8(ol)-4.9(o)-2.6(g)-17.1(y)34.4(\))23.9( u)10.6(n)2(it)-8.5(e)-6.7(s)41( )]TJ 0 Tc 0.238 Tw -13.105 -1.27 Td [(c)-14.8(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.6(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-15.6(s)-36.9(t)-55.9(s o)-20.2(f R)-14.8(u)-29.7(s)-30.2(s)-33.7(i)-13.4(a i)-11.6(n c)-22.4(l)-28.8(o)-23.7(s)-30.6(e c)-14.8(o)-26.5(o)-16.5(p)-32.4(e)-20.2(r)-38.3(a)-26(t)-53.2(i)-15.1(o)-17.4(n w)-52.8(i)-23.8(t)-33.8(h p)-21.8(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.1(s)-33.7(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l a)-34.2(s)-30.2(s)-26.9(o)-24.7(c)-45.5(i)-13.4(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-19.3(s )]TJ 0.023 Tw T* [(o)-20.2(f t)-33.8(h)-23.1(e w)-21.5(o)-20(r)-40(l)-32.9(d a)-15.9(n)-22.5(d l)-31.5(e)-21(a)-21(d)-23.8(i)-11.6(n)-19.9(g i)-11.6(n)-25.1(t)-32.4(e)-20.2(r)-43.3(n)-16.1(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l e)-40.6(x)-32.4(p)-32.4(e)-20.2(r)-66.3(t)-55.9(s i)-11.6(n t)-33.8(h)-23.1(e f)-69.5(i)-19.2(e)-25.8(l)-32.8(d o)-20.2(f c)-14.8(o)-23.5(l)-28.8(o)-20(r)-27(e)-27(c)-48.6(t)-44.2(a)-19.4(l s)-17(u)-15.9(r)-24.7(g)-22.4(e)-20.2(r)-67.2(y)9.2(.)]TJ 0.01 Tc 0.349 Tw T* [(T)-25.6(h)-23.1(e j)-15.1(o)-21.3(u)-15.9(r)-43.3(n)-16.1(a)-19.5(l p)-24.4(u)-21.5(b)-26.1(l)-24.7(i)-15.6(s)-17(h)-23(e)-30.6(s o)-20(r)-63.1(i)-15.1(g)-36.5(i)-11.6(n)-16.1(a)-19.5(l a)-18.3(r)-66.3(t)-53.2(i)-13.3(c)-22.4(l)-31.5(e)-30.6(s)-45.3(, t)-33.8(h)-23.1(e r)-26.9(e)-30.6(s)-17(u)-16.6(l)-23.3(t)-55.9(s o)-20.2(f b)-25.6(a)-34.2(s)-33.7(i)-13.3(c r)-27(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.6(c)-18.3(h a)-23(i)-11.5(m)-24.5(e)-28.8(d)10( )]TJ 0.212 Tw T* [(a)-26(t)]TJ /Span<>> BDC ( )Tj EMC [(s)-36.9(t)-30.2(u)-18.6(d)-28.3(y)-54.6(i)-11.6(n)-19.9(g g)-22.4(e)-19.6(n)-24(e)-20.2(r)-38.3(a)-19.5(l p)-27.9(a)-26(t)-33.8(h)-19(o)-23.5(l)-28.8(o)-26.5(g)-36.5(i)-13.3(c)-29.2(a)-19.5(l p)-21.8(r)-23.8(o)-24.7(c)-17.9(e)-30.6(s)-30.2(s)-30.6(e)-30.6(s i)-11.6(n o)-20(r)-26(d)-23.4(e)-20.2(r t)-29.7(o i)-11.6(m)-13.4(p)-21.8(r)-23.8(o)-18.4(v)-26.5(e t)-33.8(h)-23.1(e t)-38.3(r)-27(e)-21(a)-26(t)-33.8(m)-24.5(e)-19.6(n)-25.1(t)10( )]TJ 0.063 Tw 0 -1.27 TD [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-27.9(a)-26(t)-53.2(i)-19.2(e)-19.6(n)-25.1(t)-55.9(s)-45.3(, c)-22.5(l)-24.7(i)-11.5(n)-21.9(i)-13.3(c)-29.2(a)-19.5(l c)-29.2(a)-34.2(s)-30.6(e)-30.6(s)-45.3(, m)-24.5(e)-30.2(t)-44.2(a)-27.5(-)-21.1(a)-15.9(n)-16.1(a)-19.5(l)-16.6(y)-36.5(s)-30.6(e)-30.6(s)-45.3(, a)-15.9(n)-22.5(d l)-24.7(i)-23.8(t)-32.4(e)-20.2(r)-38.3(a)-26(t)-30.2(u)-15.9(r)-27(e r)-27(e)-23.8(v)-58.6(i)-19.2(e)-20.6(w)-33.3(s o)-17.4(n a w)-52.8(i)-17(d)-23.3(e r)-38.3(a)-15.9(n)-19.9(g)-22.4(e)10( )]TJ 0.278 Tw 0 -1.27 TD [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(c)-14.8(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y i)-15.6(s)-30.2(s)-17(u)-20.6(e)-30.6(s)-45.3(, a)-34.2(s w)-25.6(e)-25.8(l)-36(l a)-34.2(s t)-33.8(h)-23.1(e r)-27(e)-30.6(s)-17(u)-16.6(l)-23.3(t)-55.9(s o)-20.2(f c)-22.4(l)-24.7(i)-11.6(n)-21.9(i)-13.3(c)-29.2(a)-19.5(l a)-15.9(n)-22.5(d e)-40.6(x)-32.4(p)-32.4(e)-20.2(r)-63.1(i)-11.5(m)-24.6(e)-19.6(n)-25.1(t)-44.1(a)-19.6(l)10.1( )]TJ 0.029 Tc -0.029 Tw T* [(s)-17.9(t)-11.2(ud)-4.7(ie)-11.6(s)-4.4(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.013 Tw 7 0 0 7 274.9606 523.7008 Tm [(C)-6.5(H)-3.8(I)-3.4(EF)10( EDI)-44.1(T)-16.2(O)-3.6(R)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.162 Tw 6.3 0 0 6.3 274.9606 512.8661 Tm [(Y)1.2(u)-23(r)-59.2(i \032)-42.9(.)]TJ /Span<>> BDC ( )Tj EMC [(S)-22.9(h)-22.8(e)-24.6(l)-11.1(y)-19.4(g)-42.4(i)-20.1(n \()-4.5(M)-21(o)-20(s)-27.5(c)-14.4(o)-18(w)4.3(, R)-18.7(u)-23(s)-25.2(s)-35.6(i)-21(a)19.7(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC [(\227 D)-22.4(r)21.2(. o)-20.2(f S)-31(c)-45.5(i)-8.7(. \()2.8(M)-20.7(e)-28.8(d)-19.9(.)33.4(\))-22.6(, P)-26.5(r)-23.8(o)-20.2(f)-36.1(e)-30.5(s)-30.2(s)-26.9(o)-20(r)-4.1(, a)-19.3(c)-29.2(a)-21.1(d)-23.3(e)-19.6(m)-22.4(i)-13.3(c)-45.5(i)-13.4(a)-15.9(n )]TJ 0.271 Tw T* [(o)-20.2(f R)-51(A)-47.8(S)-38.7(, R)-37.9(y)-41.4(z)-20.6(h)-22(i)-14.8(k)-24.7(h N)-15(a)-26(t)-53.2(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l M)-20.7(e)-28.8(d)-23.8(i)-13.3(c)-29.2(a)-19.5(l R)-15(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.7(c)-18.3(h C)-27(e)-19.6(n)-25.1(t)-32.4(e)-20.2(r o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(C)-24.2(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y)-14.3(, H)-16.3(o)-17.4(n)-19.9(o)-20(r)-38.3(a)-18.3(r)-67.2(y )]TJ 0.023 Tw T* [(m)-24.5(e)-19.6(m)-16.6(b)-32.4(e)-20.2(r)]TJ /Span<>> BDC ( )Tj EMC [(o)-20.2(f E)-38.4(S)-28.9(C)-18.9(P)68.7(, P)-26.5(r)-26.9(e)-30.6(s)-33.7(i)-17(d)-23.3(e)-19.6(n)-25.1(t o)-20.2(f t)-33.8(h)-23(e R)-14.8(u)-29.7(s)-30.2(s)-33.7(i)-13.4(a)-15.9(n A)-43.7(s)-30.2(s)-26.9(o)-24.7(c)-45.5(i)-13.4(a)-26(t)-53.2(i)-15.1(o)-17.4(n o)-20.2(f C)-24.2(o)-23.6(l)-28.7(o)-16.5(p)-21.8(r)-23.8(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw 0 -1.72 TD [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf -0.002 Tc 0.857 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(79)-21.8(8)-16(9)-33.3(-)-34.9(8)-21.3(2)-12.7(2)-15.4(8)]TJ /Span<>> BDC 4.491 0 Td [( )-4626.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.516 0 Td [(A)2.3(u)-1.9(t)-8.2(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf 0.004 Tc 0.019 Tw 4.564 0 Td [( 4)-38.4(8)-27.1(0)-8.2(2)-5.9(59)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw -27.421 -1.27 Td [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc -0.008 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)18.8(2)34.2(-)-1.9(8)-11.4(4)-11.4(80)-9.9(-)18.5(9)25.2(3)19(6)24.3(2)]TJ /Span<>> BDC 9.529 0 Td ( )Tj EMC 1.765 0 Td ( )Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw 5.714 0 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf -0.006 Tc 0.029 Tw 3.662 0 Td [( I)-15.9(D)-6( 57)-4.6(2)-14.5(1)-22.2(37)13.7(6)-30.3(0)-18.2(2)-19.4(8)-33(6)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.007 Tc -0.007 Tw 7 0 0 7 274.9606 406.7008 Tm [(CO)-33.2(-)-16.9(E)-3(D)-3.6(I)-47.1(T)-19.1(O)-6.6(R)-38(S)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.083 Tw 6.3 0 0 6.3 274.9606 395.8661 Tm [(S)-33.7(e)-23.3(r)-25.3(g)-29.1(e)-27.5(i I)-36.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)-20.1(c)-19.8(h)-19.2(k)-38.4(a)-29.7(s)-26.1(o)-18.9(v \()-4.5(M)-20.9(o)-20(s)-27.5(c)-14.4(o)-18(w)4.3(, R)-18.7(u)-23(s)-25.2(s)-35.7(i)-20.9(a)19.7(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC [(\227 D)-22.4(r)21.2(. o)-20.2(f S)-30.9(c)-45.5(i)-8.7(. \()2.8(M)-20.7(e)-28.8(d)-19.9(.)33.4(\))-22.6(, P)-26.4(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.2(s)-26.9(o)-20(r)-4.1(, c)-14.8(o)-20(r)-47.7(r)-27(e)-30.6(s)-17.5(p)-30.1(o)-17.4(n)-22.5(d)]TJ 0 Tw 6.3 0 0 6.3 493.8455 395.8661 Tm (-)Tj 0.278 Tw 6.3 0 0 6.3 274.9606 387.8661 Tm [(i)-11.6(n)-19.9(g m)-24.4(e)-19.6(m)-16.6(b)-32.4(e)-20.2(r o)-20.2(f )0.5(R)-51(A)-47.8(S)-38.7(, d)-23.8(i)-14.3(r)-27(e)-26.9(c)-48.6(t)-29.7(o)-20(r o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC 14.589 0 Td [(t)-33.8(h)-23.1(e R)-37.8(y)-41.4(z)-20.6(h)-22(i)-14.8(k)-24.7(h N)-15(a)-26(t)-53.1(i)-15.1(o)-17.4(n)-16.1(a)-19.5(l M)-20.7(e)-28.8(d)-23.8(i)-13.3(c)-29.1(a)-19.6(l R)-15(e)-30.6(s)-30.6(e)-21(a)-18.3(r)-19.7(c)-18.3(h C)-27(e)-19.6(n)-25.1(t)-32.4(e)-20.2(r )]TJ 0.023 Tw -14.589 -1.27 Td [(o)-20.2(f)]TJ /Span<>> BDC ( )Tj EMC [(C)-24.3(o)-23.5(l)-28.8(o)-16.5(p)-21.8(r)-23.7(o)-24.7(c)-48.6(t)-29.7(o)-23.5(l)-28.8(o)-26.5(g)-41(y)-14.3(, m)-24.5(e)-19.6(m)-16.6(b)-32.4(e)-20.2(r o)-20.2(f E)-38.4(S)-28.9(C)-18.9(P)96(.)]TJ /T1_2 1 Tf 0.035 Tc -0.035 Tw T* [(S)16.4(P)13.2(I)18.2(N)7.4(-\220)5.2(\002)3.3(\240:)]TJ /T1_3 1 Tf 0.007 Tc 0.964 Tw /Span<>> BDC 4.481 0 Td ( )Tj EMC 1.368 0 Td [(5)-24.1(4)-24.1(67)33.6(-)51.9(1)12(0)-16.8(62)]TJ /Span<>> BDC 4.375 0 Td [( )-4510.3( )]TJ EMC /T1_2 1 Tf 0.022 Tc 0.001 Tw 12.633 0 Td [(A)2.3(u)-1.9(t)-8.1(hor)22( I)5.2(D)-1.6(:)]TJ /T1_3 1 Tf -0.029 Tc 0.947 Tw /Span<>> BDC 4.564 0 Td ( )Tj EMC [(2)-33.4(6)-39.8(51)-25.3(4)-51.1(2)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw -27.421 -1.27 Td [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc 1.568 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)21.1(1)48.7(-)18.5(9)19.8(2)16.7(9)5.7(4)-5.1(-)14.8(54)-14.5(4)46.9(7)]TJ /Span<>> BDC 9.461 0 Td ( )Tj EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw 7.546 0 Td [(S)-23.4(C)-3.4(O)-10.1(PU)-14.9(S)-17.9(:)]TJ /T1_3 1 Tf -0.007 Tc 0.03 Tw /Span<>> BDC 3.662 0 Td ( )Tj EMC 2.052 0 Td [(I)-16.9(D)-7( 6)-25.9(6)-31.3(0)-11(3)-7.8(3)-34.1(49)-23.7(6)-39.9(4)-4.2(5)]TJ /T1_2 1 Tf 0 Tc 0.105 Tw -28.571 -9.414 Td [(Y)-29.2(v)-18.9(e)-23.6(s P)-10.1(a)-21.6(n)-25.7(i)-21.4(s \()-8.1(P)-10.1(a)-23.7(r)-59.2(i)-21.4(s)-29.7(, F)-11.9(r)-35.7(a)-21.6(n)-25.1(c)-14.7(e)21.5(\))]TJ /T1_3 1 Tf /Span<>> BDC ( )Tj EMC [(\227 M)-6.8(D)-15(, P)-14.7(h)-9.2(D)-15(, U)-13.2(n)-21.9(i)-22.4(v)-26.5(e)-20.2(r)-37.8(s)-33.7(i)-23.8(t)-32.4(\351 P)-18.4(a)-18.3(r)-63.1(i)-15.6(s V)-43.8(I)-34.3(I)-44.3(, P)-26.5(r)-23.8(o)-20.2(f)-36.1(e)-30.6(s)-30.2(s)-26.9(o)-20(r o)-20.2(f S)-20.2(u)-15.9(r)-24.7(g)-22.4(e)-20.2(r)-67.2(y)-14.3(, )]TJ 0.02 Tc 0.003 Tw 0 -1.27 TD [(He)-1(a)-1.1(d)20( of)20( t)-13.8(h)-3.1(e)20( D)-9.7(e)1.2(p)-7.9(a)1.7(r)-46.3(t)-13.8(m)-4.5(e)0.5(n)-5.1(t)20( of)20( C)-4.3(o)-3.5(l)-8.8(or)-7(e)-7(c)-28.6(t)-24.1(a)0.5(l)20( Su)4.1(r)-4.6(g)-2.4(er)-47.2(y)5.7(,)20( B)-7(e)-0.9(a)2.8(u)-1.6(j)4.9(o)2.6(n)20( H)3.7(o)-3.7(s)2.6(p)-6.5(i)-3.8(t)-24.2(a)0.5(l)-19.2(.)]TJ /T1_2 1 Tf 0.017 Tc -0.017 Tw 0 -1.72 TD [(OR)1.6(C)-27.8(ID)-6.6(:)]TJ /T1_3 1 Tf 0.031 Tc 0.736 Tw /Span<>> BDC 3.027 0 Td ( )Tj EMC 2.823 0 Td [(0000)-9.9(-)-9.4(000)21.1(1)48.7(-)18.5(9)18.9(5)22.9(5)31.1(3)9.6(-)18.5(9)29.8(7)32.5(2)27.4(7)]TJ /Span<>> BDC 9.355 0 Td [( )-938.6( )]TJ EMC /T1_2 1 Tf 0.007 Tc -0.007 Tw [(S)-23.3(C)-3.4(O)-10.1(PU)-14.8(S)-18(:)]TJ /T1_3 1 Tf 0.004 Tc 0.763 Tw /Span<>> BDC 10.601 0 Td ( )Tj EMC [(I)-5.9(D)4( )743.7(3)8.6(527)5.9(5)-23.5(8)-23(6)-20.3(0)-31.7(4)-31.7(0)-27.1(0)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.013 Tw 7 0 0 7 274.9606 262.7008 Tm [(E)-40.4(X)-19.4(EC)-9.8(U)-23.5(T)-51(I)-33.6(V)-8.4(E)10( S)-5.2(EC)-6.5(R)-6.5(E)-44.1(T)21(A)-7.9(R)-8.8(Y)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.262 Tw 6.3 0 0 6.3 274.9606 251.8661 Tm [(E)-16(v)-22.1(g)-29.1(e)-23.1(n)-19.8(y )0.6(G)-28.4(.)]TJ /Span<>> 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