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AFC $F)10(r)-24(ench Sur)-32(gical )]TJ 0.128 Tw -1.796 -1.25 Td [(Asso)-16(c)-23.9(ia)15(t)-32(ion$ W)20(or)-24(k)-15.9(ing G)20(r)-32(oup. Wha)15.1(t is t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(best opt)-32(ion be)-12(t)-32(ween p)25(r)-37(i)]TJ 0 Tw (-)Tj -0.003 Tw 0 -1.25 TD [(mar)-24(y di)-16(ver)-22(t)-31.9(ing st)17(oma or end)-15.9(oscopic stent as a)]TJ /Span<>> BDC ( )Tj EMC [(br)-37(idge t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-24(y wi)-24(t)-13(h )]TJ -0.022 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(cur)-33(a)15.1(t)-32(i)-16(ve intent for obstr)-22(uc)-16(ted lef)-28(t col)30(on cancer? R)13(esul)56.1(ts fr)-32(om a)]TJ /Span<>> BDC ( )Tj EMC [(p)25.1(r)-32(o)]TJ 0 Tw (-)Tj 0.016 Tw T* [(pensi)-24(t)-9.9(y scor)-24(e anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he F)10(r)-24(ench sur)-31.9(gical asso)-16(c)-24(ia)15(t)-31.9(ion mul)56(t)-32(icenter )]TJ 0.165 Tw T* [(cohor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC [(518 p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf 10.154 0 Td (Ann Surg Oncol)Tj /T1_0 1 Tf (. 2019 Mar;26$3$:756\226764. )Tj 0 Tw -10.154 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1245/s10434-018-07139-0)Tj 0 0 0 1 k /GS1 gs 0.242 Tw -1.847 -1.25 Td (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Amel)35(ung)]TJ /Span<>> BDC ( )Tj EMC [(F)-10(J, Mulder)]TJ /Span<>> BDC ( )Tj EMC [(CL, V)30(er)-24(heijen)]TJ /Span<>> BDC ( )Tj EMC [(PM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-24.9(cute r)-24(esec)-16(t)-32(ion )]TJ 0.346 Tw -1.796 -1.25 Td [(ver)-10(sus br)-37(idge t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-23.9(y wi)-23.9(t)-13(h di)-16(ver)-22(t)-32(ing col)30(ost)17(omy for p)32(a)15(t)-32(ients )]TJ 0.278 Tw T* [(wi)-24(t)-12.9(h a)-17(cute mal)-31(ignant lef)-28(t sided col)30.1(onic obstr)-21.9(uc)-16(t)-32(ion: Sy)-13(stema)15.1(t)-32(ic )]TJ 0.005 Tc 0.35 Tw T* [(r)-24.3(ev)-16.4(iew and me)-12.4(t)14.7(a-anal)34.6(y)-13.3(sis. )]TJ /T1_1 1 Tf (Surg Oncol.)Tj /T1_0 1 Tf [( 2015 Dec;24$4$:313\22621.)5( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1016/j.sur)-31.9(onc.2015.10.003)]TJ 0 0 0 1 k /GS1 gs 0.009 Tc 0.351 Tw -1.847 -1.25 Td (37.)Tj /Span<>> BDC ( )Tj EMC 1.833 0 Td [(K)-16.3(a)9.6(w)-12.3(a)-17.3(chi)]TJ /Span<>> BDC ( )Tj EMC [(J, K)-16.4(ashiw)-12.4(a)-17.3(gi)]TJ /Span<>> BDC ( )Tj EMC [(H, S)-16.3(himoy)21.7(ama)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)9.7(p)31.6(ar)-37.3(ison)9( )]TJ 0 Tc 0.107 Tw -1.833 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(ef)-56(f)-28(ica)-17(c)-23.9(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he self-e)-18(xp)32.1(and)42(able me)-12(t)15(all)-31(ic stent ver)-9.9(sus tr)-33(ansanal )]TJ 0.024 Tw T* [(dr)-33(aina)-17(ge tube and emer)-32(gency sur)-32(ger)-24(y for mal)-31(ignant lef)-27.9(t-sided col)30(on )]TJ 0 Tw T* [(obstr)-22(uc)-15.9(t)-32(ion. )]TJ /T1_1 1 Tf 0.045 Tw 5.305 0 Td (Asian J Surg.)Tj /T1_0 1 Tf [( 2018 Sep;41$5$:498\226505. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -5.305 -1.25 Td (asjsur.2017.06.003)Tj 0 0 0 1 k /GS1 gs 0.096 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(tsud)42(a)]TJ /Span<>> BDC ( )Tj EMC [(A, Y)50(amad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Ma)15(tsumo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(hor)-22(t-ter)-15.9(m outcomes )]TJ 0.012 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(self-e)-17.9(xp)32(and)42(able me)-12(t)15.1(all)-31(ic stent as a)]TJ /Span<>> BDC ( )Tj EMC [(br)-37(idge t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(ger)-24(y vs. a)]TJ /Span<>> BDC ( )Tj EMC [(tr)-33(ans)]TJ 0 Tw (-)Tj 0.281 Tw T* [(anal decom)10(p)25(r)-24(ession tube for mal)-31(ignant l)-16(ar)-31.9(ge-bo)-14(wel obstr)-21.9(uc)-16(t)-32(ion: )]TJ -0.002 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(me)-12(t)15(a-anal)35(y)-13(sis)]TJ /T1_1 1 Tf [(. Surg T)53(od)26(ay)]TJ /T1_0 1 Tf [(. 2019 Sep;49$9$:728\226737. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj T* (s00595-019-01784-y)Tj 0 0 0 1 k /GS1 gs 0.198 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC [(Y, F)20(an)]TJ /Span<>> BDC ( )Tj EMC (Z, Zhao)Tj /Span<>> BDC ( )Tj EMC [(L. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-31.9(ole of)]TJ /Span<>> BDC ( )Tj EMC [(col)30.1(onic stents in e)-18(xtr)-32.9(a)-17(co)]TJ 0 Tw (-)Tj 0.107 Tw -1.796 -1.25 Td [(l)30(onic mal)-30.9(ignant l)-16(ar)-31.9(ge-bo)-14(wel obstr)-21.9(uc)-16(t)-32(ion. )]TJ /T1_1 1 Tf (Gastrointest Endosc)Tj /T1_0 1 Tf (. 2019 )Tj 0.023 Tw T* [(F)10(eb;89$2$:441. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2018.08.016)Tj 0 0 0 1 k /GS1 gs 0.016 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Donl)30(on)]TJ /Span<>> BDC ( )Tj EMC [(NE, K)25(ell)35(y)]TJ /Span<>> BDC ( )Tj EMC [(ME, Nar)-32(ouz)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(onic stent)-32(ing as a)]TJ /Span<>> BDC ( )Tj EMC [(br)-36.9(idge )]TJ 0.153 Tw -1.796 -1.25 Td [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 1.221 0 Td [(sur)-32(ger)-23.9(y in )0.5(mal)-30.9(ignant )0.5(l)-16(ar)-32(ge )0.5(bo)-14(wel )0.5(obstr)-22(uc)-15.9(t)-32(ion: )0.5(oncol)30(o)-16(gical )0.5(out)]TJ 0 Tw (-)Tj -1.221 -1.25 Td (comes)Tj /T1_1 1 Tf 0.081 Tw [(. )0.5(Int )0.5(J )0.5(Colorectal )0.6(Dis)]TJ /T1_0 1 Tf [(. )0.5(2019 )0.5(Ap)25(r;34$4$:613\226619. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 23.899 0 Td (10.1007/)Tj -23.899 -1.25 Td (s00384-019-03239-9)Tj 0 0 0 1 k /GS1 gs 0.128 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hohenber)-32(ger)]TJ /Span<>> BDC ( )Tj EMC [(W, W)22(eber)]TJ /Span<>> BDC ( )Tj EMC [(K, Ma)15(tzel)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(t)15(and)42(ar)-24(dized sur)-32(ger)-24(y )]TJ -0.023 Tw -1.796 -1.25 Td [(for col)30.1(onic cancer: com)10(ple)-12(te meso)-16(col)-31(ic e)-18(x)-12.9(c)-24(ision and centr)-32.9(al l)-31(iga)15(t)-32(ion-)]TJ 0.092 Tw T* [(-technical )0.6(no)17(tes )0.6(and )0.6(outcome. )]TJ /T1_1 1 Tf 12.865 0 Td [(Colorectal )0.6(Dis.)]TJ /T1_0 1 Tf [( )0.5(2009 )0.6(Ma)15(y;11$4$:354\226)]TJ 0.023 Tw -12.865 -1.25 Td [(64; discussion 364-5. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1463-1318.2008.01735.x)Tj 0 0 0 1 k /GS1 gs 0.144 Tw 29.055 40 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(o)17(t)-13(hes)]TJ /Span<>> BDC ( )Tj EMC [(H, Bauschk)10.1(e)]TJ /Span<>> BDC ( )Tj EMC [(A, S)-23.9(chuele)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-31.9(ger)-24(y for col)30(or)-24(ec)-16(t)15(al )]TJ 0.123 Tw -1.796 -1.25 Td [(cancer in elder)-29.9(l)35(y p)32(a)15.1(t)-32(ients: ho)-14(w can we im)10(p)25(r)-32(ove outcome? )]TJ /T1_1 1 Tf (J Cancer )Tj 0.136 Tw T* [(R)21(es Clin Oncol.)]TJ /T1_0 1 Tf [( 2017 Sep;143$9$:1879\2261889. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00432-)Tj T* (017-2438-y)Tj 0 0 0 1 k /GS1 gs 0.132 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(abol)-16(a)]TJ /Span<>> BDC ( )Tj EMC (R, Mantese)Tj /Span<>> BDC ( )Tj EMC [(G, Cir)-31.9(o)-16(cchi)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost)17(oper)-32.9(a)15(t)-32(i)-16(ve mor)-22(t)15.1(al)-31(i)-24(t)-10(y )]TJ 0.105 Tw -1.796 -1.25 Td [(and mor)-24(bidi)-24(t)-10(y in older p)32(a)15(t)-31.9(ients under)-31.9(going emer)-31.9(gency r)-36.9(ight hemi)]TJ 0 Tw (-)Tj 0.135 Tw T* [(colec)-16(t)17(omy )0.5(for )0.5(col)30(on cancer)]TJ /T1_1 1 Tf [(. )0.5(A)11(ging Clin )0.5(Exp R)21(es)]TJ /T1_0 1 Tf [(. )0.5(2017 F)10(eb;29$Suppl )]TJ 0.023 Tw T* [(1$:121\226126. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s40520-016-0643-1)Tj 0 0 0 1 k /GS1 gs 0.02 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(De S)-16(imone)]TJ /Span<>> BDC ( )Tj EMC [(B, Co)-16(ccol)-30.9(ini)]TJ /Span<>> BDC ( )Tj EMC [(F, Ansal)30(oni)]TJ /Span<>> BDC ( )Tj EMC [(L. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(pl)-30.9(ica)15(ted col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.245 Tw -1.796 -1.25 Td [(t)15(al cancer in nona)-17(genar)-37(ian p)32(a)15(t)-32(ients: is i)-24(t be)-12(t)-30(ter no)17(t t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(per)-24(for)-16(m )]TJ 0.308 Tw T* [(anast)17(omosis in emer)-32(gency? )]TJ /T1_1 1 Tf [(Ulus T)56(ravma Acil Cer)-16(rahi Derg)]TJ /T1_0 1 Tf (. 2017 )Tj 0.023 Tw T* [(Jan;23$1$:15\22622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5505/tjtes.2016.77178)Tj 0 0 0 1 k /GS1 gs 0.258 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chl)-31(ichtemeier)]TJ /Span<>> BDC ( )Tj EMC [(S, L)35(o)-16(gar)-32.9(aj)]TJ /Span<>> BDC ( )Tj EMC (A, Gill)Tj /Span<>> BDC ( )Tj EMC [(AJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30.1(or)-24(ec)-16(t)15(al cancer )]TJ 0.252 Tw -1.796 -1.25 Td [(r)-24(esec)-15.9(t)-32(ion in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(A)10(ustr)-32.9(al)-31(ian nona)-17(genar)-37(ian p)32(a)15(t)-32(ient. )]TJ /T1_1 1 Tf (Colorectal Dis)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017 Mar;19$3$:243\226250. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.13434)Tj 0 0 0 1 k /GS1 gs 0.022 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(ir)-23.9(r)-24(er)-33(a)]TJ /Span<>> BDC ( )Tj EMC 3.024 0 Td [(B, )0.5(V)25(a)-17(ccar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC 4.163 0 Td [(S, )0.5(Cuicchi)]TJ /Span<>> BDC ( )Tj EMC 4.093 0 Td [(D, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.081 0 Td [(al. )0.5(Im)10.1(p)32(a)-17(c)-16(t )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.436 0 Td [(o)-16(c)-16(t)17(o)-16(genar)-36.9(ians )0.5(on )]TJ 0.086 Tw -20.593 -1.25 Td [(sur)-32(gical outcome in col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_1 1 Tf (Int J Surg)Tj /T1_0 1 Tf [(. 2016 N)-13.9(ov;35:28\226)]TJ 0.023 Tw T* [(33. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijsu.2016.09.006)Tj 0 0 0 1 k /GS1 gs 0.102 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ming-Gao)Tj /Span<>> BDC ( )Tj EMC (G, Jian-Zhong)Tj /Span<>> BDC ( )Tj EMC [(D, Y)35(u)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(or)-24(ec)-16(t)15.1(al cancer tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.044 Tw -1.796 -1.25 Td [(ment in o)-15.9(c)-16(t)17(o)-16(genar)-37(ians: elec)-15.9(t)-32(i)-16(ve or emer)-32(gency sur)-32(ger)-23.9(y? )]TJ /T1_1 1 Tf [(W)29(orld J Surg )]TJ 0 Tw T* (Oncol)Tj /T1_0 1 Tf 0.023 Tw [(. 2014 Dec 17;12:386. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1477-7819-12-386)Tj 0 0 0 1 k /GS1 gs 0.127 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(olfscho)17(ten)]TJ /Span<>> BDC ( )Tj EMC [(NE, W)20(outer)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(MW, Go)-16(oik)10(er)]TJ /Span<>> BDC ( )Tj EMC [(GA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R] endobj 106 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 341.3784 42.7216 Tm [(Sur)31(gical appr)20(oach for acute colon tumor obstr)10(uction )]TJ 2.798 -1 Td [(in elderly and octogenarian patients $r)31.1(e)11(vie)11(w$)]TJ -42.646 1 Td [(\224\b\017\220\017\020\b\213\f\205\007\005 \026)11(\005\007)-10(\026\b\007\005 \223\017\b\022\025\205)-10(\026\017\025\255 \025\210\026)-19.9(\220\017\005\216\b\025\t\t\025\255 )]TJ 0 -1 TD [(\t\f\223\017\025\002\025\217\b\024\025\205)-10(\026\b \025\223\220)21(\002\025\013\f\016\025\020)10(\025 \020)10(\f\t\f\001\005 \220\022\210\025\013\n\t\240\002 \223\025\235\b\013\025\020\ )10(\025 )]TJ T* [(\b\022\205)-10(\026)11(\005\017\213\f\205\007)10(\025\020)10(\025 \016\025)21(\001\017\005\205)-10(\026)11(\005 $\025\210\001\025\017 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F)20(a)-17(c)-16(t)17(or)-9.9(s asso)-16(c)-23.9(ia)15(ted wi)-24(t)-13(h )]TJ 0.213 Tw -1.796 -1.25 Td [(emer)-32(gency-onse)-11.9(t dia)-17(gnosis, t)-32(ime t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment and t)-10(ype of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.046 Tw 0 -1.25 TD [(ment in col)30(or)-23.9(ec)-16(t)15(al cancer p)32(a)15(t)-32(ients in N)-13.9(or)-37.9(w)-12(a)15(y. )]TJ /T1_2 1 Tf (BMC Cancer)Tj /T1_1 1 Tf (. 2021 Jun )Tj 0.023 Tw T* [(30;21$1$:757. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s12885-021-08415-1)Tj 0 0 0 1 k /GS1 gs 0.151 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC 3.742 0 Td [(\225.\230., )0.5(\207\026\020\026\021\036\035\017\016)]TJ /Span<>> BDC ( )Tj EMC 6.8 0 Td [(\003.\202., )0.5(\207\026\020\027\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 6.393 0 Td [(\225.\205., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.163 0 Td [(\f\024\026\r\021. )0.5(\210\f\021\030\026\016 )]TJ 0.288 Tw -21.894 -1.25 Td (\021\024\035\f\021\024\022\017\001\036\004\027\026\016 \027\036\023\030\024\ \b\024\007\017\n\024\f\021\034 \024\023\031\b\024\035\036\r\024\005 \220\ \021\017\024\035\024\020\017\017 $\02556.6; )Tj 0.302 Tw T* (\22518, \22519, \22520$, \r\030\024\f\035\t\036. )Tj /T1_2 1 Tf 0 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0.302 Tw (. 2023;22$2$:10\22631. )Tj 0.023 Tc -0.023 Tw T* [(d)-15.5(o)0.5(i)0.6(:)]TJ /Span<>> BDC 1.681 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.066 0 Td [(1)0.5(0)0.5(.)0.5(3)0.6(3)0.5(8)0.5(7)0.5(8)0.5(/)0.5(2)0.5(0)0.5(7)0.6(3)0.5(-)0.5(7)0.5(5)0.5(5)0.5(6)0.5(-)0.6(2)0.5(0)0.5(2)0.5(3)0.5(-)0.5(2)0.6(2)0.5(-)0.5(2)0.5(-)0.5(1)0.5(0)0.5(-)0.6(3)0.5(1)]TJ 0 0 0 1 k /GS1 gs 0.81 Tw 16.615 0 Td [( /)0.5(A)-24.4(c)0.5(h)0.5(k)-16.5(a)0.5(s)0.5(o)0.5(v)]TJ /Span<>> BDC 5.506 0 Td ( )Tj EMC [(S)0.5(.)0.5(I)0.5(.)0.6(,)23( )]TJ 0.006 Tc 0.349 Tw -24.868 -1.25 Td [(Ba)-16.9(ga)15.1(tel)-30.9(ia)]TJ /Span<>> BDC ( )Tj EMC [(Z.A., Ba)-16.8(gnenko)]TJ /Span<>> BDC ( )Tj EMC [(S.F. e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-24.8(cute mal)-30.8(ignant col)30.1(or)-23.8(ec)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc 0.349 Tw T* [(t)15.5(a)0.5(l)0.6( o)0.5(b)0.6(s)0.5(t)0.5(r)-21.5(u)0.6(c)-15.5(t)-31.5(i)0.5(o)0.5(n)0.6( $)0.5(K)0.6(5)0.5(6)0.5(.)0.5(6)0.5(;)0.6( C)0.5(1)0.5(8)0.5(,)0.6( C)0.5(1)0.5(9)0.6(,)0.5( C)0.5(2)0.6(0)0.5($)0.5(,)0.5( a)0.6(d)0.5(u)0.5(l)56.5(t)0.6(s)0.5(.)0.5( )]TJ /T1_2 1 Tf -0.005 Tw [(K)18.6(o)0.5(l)0.5(o)0.5(p)46.5(r)0.6(o)0.5(k)0.5(t)0.6(o)0.5(l)0.5(o)0.5(g)0.5(i)0.6(a)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.342 0 Td (. )Tj 0.18 Tw -27.342 -1.25 Td [(2023;22$2$:10\22631. $In Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2023-22-)Tj T* (2-10-31)Tj 0 0 0 1 k /GS1 gs 0.246 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\026\002\031\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \207\026\020\026\021\036\035\017\016)Tj /Span<>> BDC ( )Tj EMC (\003.\202., \206\031\020\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200. \217\036\031\035\034\021\026\021\t \r\027\036)Tj 0 Tw (-)Tj 0.004 Tc 0.349 Tw -1.796 -1.25 Td (\007\030\036\027\017\016 \220\021\026\023\027\024\020\024 \035\036\004\036\ \027\017\016 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\024\ \030\026\022\026, \024\f\035\024\032\027\036\027\027\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.432 Tw T* (\020\024 \024\002\021\031\030\026\006\017\024\027\027\024\005 \022\017\001\ \036\004\027\024\005 \027\036\023\030\024\b\024\007\017\n\024\f\021\034\033\ , \r)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\027\007\026\030\021\t)12( )]TJ 0.011 Tc 0.398 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \ \024\027\022\024\035\024\020\017\004\036\f\022\017\n \002\024\035\034\027\ \t\n \020. \204\024\f\022\r\t.)11( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0.037 Tw [(. 2018;$4$:7\22615. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2018-)Tj T* (0-4-7-15)Tj 0 0 0 1 k /GS1 gs -0.092 Tw [( /S)-16(habunin)]TJ /Span<>> BDC ( )Tj EMC 8.076 0 Td [(A.V., )0.5(Ba)-17(ga)15(tel)-31(iy)22(a)]TJ /Span<>> BDC ( )Tj EMC (Z.A., Gugnin)Tj /Span<>> BDC ( )Tj EMC [(A.V. )0.5(Im)10(plement)15(a)15(t)-32(ion )]TJ 0.036 Tw -8.076 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(mul)56.1(t)-32(ist)15(a)-17(ge app)25(r)-32(oa)-17(ch for col)30(or)-24(ec)-15.9(t)15(al cancer wi)-24(t)-13(h bo)-14(wel obstr)-22(uc)-16(t)-31.9(ion )]TJ 0.244 Tw T* [(in sur)-32(geon uni)-23.9(ts of)]TJ /Span<>> BDC ( )Tj EMC [(M)-23.9(osco)-14(w. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.244 Tw (. 2018;$4$:7\22615. $In )Tj 0.023 Tw T* [(Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2018-0-4-7-15)Tj 0 0 0 1 k /GS1 gs 0.122 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\031\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\213. \210\002\021\031\030\026\006\017\024\027\027\026\016 \024\023\ \031\b\024\035\036\r\026\016 \021\024\035\f\021\024)Tj 0 Tw (-)Tj 0.001 Tc 0.35 Tw -1.796 -1.25 Td [(\022\017\001\036\004\027\026\016 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\034. )0.5(\204\024\f\022\r\026: )0.5(\210\002\013\036\f\021\r\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 21.785 0 Td [(\024\020\030\026\027\017\004\036\027\027\024\005)1( )]TJ 0 Tc 0.113 Tw -21.785 -1.25 Td (\024\021\r\036\021\f\021\r\036\027\027\024\f\021\034\033 \253\203\026\031\ \004\027\024-\017\007\026\021\036\035\034\f\022\017\005 \006\036\027\021\ \030 \230\203\205\217\202-\204\273. 2019; )Tj 0.138 Tw T* [(170 \f. /P)20(ugaev)]TJ /Span<>> BDC ( )Tj EMC [(A.V., A)-25(chk)-17(asov)]TJ /Span<>> BDC ( )Tj EMC [(E.E. Ob)16(tur)-33(a)15(t)-32(i)-15.9(ve col)30(onic obstr)-21.9(uc)-16(t)-32(ion )]TJ 0.167 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(tumor. M)-23.9(osco)-14(w: \253S)-24(c)-24(ient)-31.9(if)-28(ic P)20(ubl)-31(ishing Center INFRA-M\273. 2019; )]TJ 0.023 Tw T* (170 p. $In Russ.$.)Tj 0.03 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\236\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\225.\203. \202\027\026\035\017 \r\t\032\017\r\026\036\n\024\f\021\017 \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\024\n \022\024\035\024\030\036\022)Tj 0 Tw (-)Tj 0.276 Tw -1.796 -1.25 Td (\021\026\035\034\027\024\n \030\026\022\036. )Tj /T1_2 1 Tf (\211\020\021\034\027\034\013\022\n\016\024\021\037\030 \021\034\027\034\f\ \033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf (. 2017;7$2$:20\226)Tj 0.152 Tw T* [(29. / S)-16(hchaev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(S.N. Anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(v)-16(i)-16(v)-15(al in com)10(pl)-31(ica)15.1(ted col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* (cancer. )Tj /T1_2 1 Tf 0.023 Tw 3.19 0 Td [(Oncological Colop)46(roctology.)]TJ /T1_1 1 Tf ( 2017;7$2$:20\22629. $In Russ.$].)Tj -0.01 Tw -3.19 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(isano)]TJ /Span<>> BDC ( )Tj EMC 2.907 0 Td [(M, )0.5(Z)25(or)-32(col)30(o)]TJ /Span<>> BDC ( )Tj EMC 4.229 0 Td [(L, )0.5(Mer)-30(l)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC 3.122 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.928 0 Td [(al. )0.5(2017 )0.5(WSES )0.5(guidel)-30.9(ines )0.5(on )0.5(col)30(on )]TJ 0.028 Tw -13.982 -1.25 Td [(and r)-24(ec)-16(t)15(al cancer emer)-32(genc)-23.9(ies: obstr)-22(uc)-16(t)-32(ion and per)-24(for)-32.9(a)15(t)-32(ion. )]TJ /T1_2 1 Tf 0 Tw [(W)29(orld)]TJ /T1_1 1 Tf ( )Tj /T1_2 1 Tf 27.2 0 Td (J )Tj 0.023 Tw -27.2 -1.25 Td (Emerg Surg.)Tj /T1_1 1 Tf [( 2018 A)10(ug 13;13:36. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-018-0192-3)Tj 0 0 0 1 k /GS1 gs 0.009 Tc 0.353 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.834 0 Td [(Ma)-24.4(z)-24.4(zo)16.6(t)-30.3(t)14.6(a)]TJ /Span<>> BDC ( )Tj EMC [(AD, Bur)-22.4(t)-32.3(i)]TJ /Span<>> BDC ( )Tj EMC (E, Causio)Tj /Span<>> BDC ( )Tj EMC [(F)23.6(A, e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)-17.3(chine lear)-15.4(ning)9( )]TJ 0 Tc 0.057 Tw -1.834 -1.25 Td [(app)25(r)-32(oa)-17(ches for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-23.9(edic)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(post)17(oper)-33(a)15(t)-31.9(i)-16(ve major com)10(pl)-31(ica)15(t)-32(ions )]TJ 0.146 Tw T* [(in p)32(a)15(t)-32(ients under)-32(going sur)-32(ger)-24(y for bo)-14(wel obstr)-22(uc)-16(t)-32(ion. )]TJ /T1_2 1 Tf [(J P)15(ers Med.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2024 O)-16(c)-16(t 8;14$10$:1043. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jpm14101043)Tj 0 0 0 1 k /GS1 gs 0.182 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ebell)Tj /Span<>> BDC ( )Tj EMC 2.382 0 Td [(MH, )0.5(T)47(hai)]TJ /Span<>> BDC ( )Tj EMC 3.967 0 Td [(TN, )0.5(R)11(oy)22(al)56(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC 4.976 0 Td [(K)20(J. )0.5(Cancer )0.5(scr)-23.9(eening )0.5(r)-24(ecommend)42(a)]TJ 0 Tw (-)Tj 0.043 Tw -13.121 -1.25 Td [(t)-32(ions: an)]TJ /Span<>> BDC ( )Tj EMC [(inter)-15(na)15(t)-32(ional com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(high-income countr)-37(ies. )]TJ /T1_2 1 Tf 0 Tw (Public )Tj 0.023 Tw T* [(Health R)21.1(ev.)]TJ /T1_1 1 Tf [( 2018 Mar 2;39:7. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s40985-018-0080-0)Tj 0 0 0 1 k /GS1 gs 0.098 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\026\002\031\027\017\027)Tj /Span<>> BDC ( )Tj EMC 4.1 0 Td [(\202.\200., )0.5(\207\026\020\026\021\036\035\017\016)]TJ /Span<>> BDC ( )Tj EMC 6.701 0 Td [(\003.\202. )0.5(\202\035\020\024\030\017\021\n )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.6(\023\024\n\024)]TJ 0 Tw (-)Tj 0.296 Tw -12.597 -1.25 Td (\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\024\n \022\024\035\024\030\036\022\021\ \026\035\034\027\024\n \030\026\022\036. )Tj /T1_2 1 Tf 0 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf (. )Tj 0.005 Tc 0.35 Tw T* [(2019;18$1$:66\22673. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2019-18-1-66-73)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.355 Tw ( /)Tj 0.167 Tw T* [(S)-16(habunin)]TJ /Span<>> BDC ( )Tj EMC 4.195 0 Td [(A.V., )0.6(Ba)-17(ga)15(tel)-31(iy)22(a)]TJ /Span<>> BDC ( )Tj EMC 6.878 0 Td [(Z.A. )0.6(Al)16(gor)-37(i)-23.9(t)-13(hm )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.66 0 Td [(sur)-32(gical )0.6(car)-24(e )0.6(in )0.5(com)]TJ 0 Tw (-)Tj 0.174 Tw -18.734 -1.25 Td [(pl)-31(ica)15(ted col)30(or)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.174 Tw (. 2019;18$1$:66\22673. $In )Tj 0 Tw T* (Russ.$].)Tj 0.007 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bal)16(c)-24(iscue)-11.9(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(I, Bal)16(c)-24(iscue)-12(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(Z, U)15(r)-37(ibe)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)30(er)-37(ineur)-32.9(al inv)-15(asion is )]TJ 0.097 Tw -1.796 -1.25 Td [(incr)-24(eased in p)32(a)15(t)-32(ients r)-24(ecei)-16(v)-16(ing col)30(onic stent)-32(ing as a)]TJ /Span<>> BDC ( )Tj EMC [(br)-37(idge t)17(o)]TJ /Span<>> BDC ( )Tj EMC (sur)Tj 0 Tw 27.286 0 Td (-)Tj 0.08 Tw -27.286 -1.25 Td [(ger)-24(y: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_2 1 Tf [(T)54(ech Colop)46(roctol.)]TJ /T1_1 1 Tf ( 2021 )Tj 0.023 Tw T* [(F)10(eb;25$2$:167\226176. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-020-02350-2)Tj 0 0 0 1 k /GS1 gs 0.146 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ber)-10(sell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, Bor)-24(r)-32(oni)]TJ /Span<>> BDC ( )Tj EMC [(G, L)-31.9(i)-16(vr)-33(a)-17(ghi)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ap)32(ar)-32(oscopic app)25(r)-31.9(oa)-17(ch )]TJ 0.137 Tw -1.796 -1.25 Td [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(l)-15.9(ar)-32(ge bo)-14(wel neopl)-15.9(ast)-32(ic obstr)-21.9(uc)-16(t)-32(ion af)-27.9(ter self-e)-17.9(xp)32(and)42(able-me)-12(t)15(al-)]TJ 0.141 Tw T* [(stent $sems$ pl)-15.9(a)-17(cement. )]TJ /T1_2 1 Tf [(Surg Laparosc Endosc P)15(ercutan T)54.1(ech.)]TJ /T1_1 1 Tf ( 2019 )Tj 0.023 Tw T* [(Ap)25(r;29$2$:133\226137. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/SLE.0000000000000623)Tj 0 0 0 1 k /GS1 gs 0.184 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ca)15(tena)]TJ /Span<>> BDC ( )Tj EMC [(F, De S)-16(imone)]TJ /Span<>> BDC ( )Tj EMC [(B, Co)-15.9(ccol)-31(ini)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Bo)-14(wel obstr)-22(uc)-16(t)-32(ion: )]TJ 0.105 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(nar)-24(r)-33(a)15(t)-32(i)-16(ve r)-24(ev)-15.9(iew for all phy)-13(sic)-23.9(ians. )]TJ /T1_2 1 Tf [(W)29(orld J Emerg Surg)]TJ /T1_1 1 Tf [(. 2019 Ap)25(r )]TJ 0.023 Tw T* [(29;14:20. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-019-0240-7)Tj 0 0 0 1 k /GS1 gs 0.278 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)50(r)-37(igui)]TJ /Span<>> BDC ( )Tj EMC [(A, R)13(ejab)]TJ /Span<>> BDC ( )Tj EMC [(H, Akr)-31.9(out)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-33(aison entr)-23.9(e stent )]TJ 0.003 Tc 0.349 Tw -1.796 -1.25 Td [(end)-15.6(oscopique e)-11.6(t col)30.4(ost)17.3(omie pour les cancer)-9.6(s col)-30.6(iques gauches)3( )]TJ 0 Tc 0.206 Tw T* [(en o)-16(ccl)35(usion: r)-23.9(evue de l)-16(a l)-31(i)-23.9(t)-30(t\351r)-33(a)15(tur)-23.9(e [Com)10(p)32(ar)-36.9(ison be)-12(t)-32(ween end)-16(o)]TJ 0 Tw (-)Tj 0.172 Tw T* [(scopic stent)-31.9(ing and col)30(ost)17(omy in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(obstr)-22(uc)-15.9(t)-32(ing )]TJ 0.348 Tw T* [(cancer )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.614 0 Td [(t)-13(he )0.6(lef)-28(t )0.5(col)30.1(on: )0.5(L)-32(i)-24(ter)-32.9(a)15(tur)-24(e )0.6(r)-24(ev)-16(iew]. )]TJ /T1_2 1 Tf 15.533 0 Td [(Presse )0.6(Med.)]TJ /T1_1 1 Tf [( )0.6(2019 )]TJ 0.023 Tw -20.147 -1.25 Td [(F)10(eb;48$2$:173\226180. F)10.1(r)-24(ench. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.lpm.2019.01.007)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.43 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.843 0 Td (\003\026\r\030\026\032\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \225\024\035\024\r\034\201\r)Tj /Span<>> BDC ( )Tj EMC (\230.\202., \215\026\r\036\035\036\006)Tj /Span<>> BDC ( )Tj EMC (\025.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)12( )]TJ 0.007 Tc 0.35 Tw -1.843 -1.25 Td [(\204\027\024\020\024\220\021\026\023\027\024\036 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\036 )0.5(\035\036\004\036\027\017\036 )0.5(\002\024\035\034\027\024\020\024 )0.5(\030\026\022\024\n \f\017\020\n\024)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.349 Tw 29.055 81.25 Td [(\r\017\007\027\024\005 \022\017\001\022\017, \024\f\035\024\032\027\036\027\ \027\t\n \f\031\023\030\026\f\021\036\027\024\021\017\004\036\f\022\017\n\ \017 \030\026\030\t\r\026\n\017)4( )]TJ 0 Tc 0.213 Tw T* (\f\021\036\027\022\017 \024\002\024\007\024\004\027\024\005 \022\017\001\ \022\017 \r\007\026\035\017 \024\021 \024\023\031\b\024\035\017. )Tj /T1_2 1 Tf (\215\016\024\035\020\022\021 \222\240\214\212 \022\b. )Tj 0.189 Tw T* [(\222.\235. )0.5(\201\022\033\034\013\034\036\037.)]TJ /T1_1 1 Tf [( )0.5(2022;17$3$:148\226149. )0.5(d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 17.899 0 Td (10.25881/20728255_20)Tj -17.899 -1.25 Td (22_17_3_148)Tj 0 0 0 1 k /GS1 gs 0.142 Tw [( /Z)10(avr)-32.9(a)-24(zhnov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., S)-16(ol)30(ov)-16.9(yov)]TJ /Span<>> BDC ( )Tj EMC [(I.A., P)40(avele)-12(ts)]TJ /Span<>> BDC ( )Tj EMC [(K.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.012 Tw T* [(Mul)56(t)-31.9(ist)15(a)-17(ge )0.5(sur)-32(gical )0.6(tr)-24(ea)15(tment )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 13.226 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 0.707 0 Td [(p)32(a)15(t)-32(ient )0.6(wi)-24(t)-13(h )0.5(sigmoid )0.6(col)30(on )0.6(cancer )]TJ 0.203 Tw -13.933 -1.25 Td [(com)10(pl)-31(ica)15.1(ted b)12(y sup)25(r)-33(asteno)17.1(t)-32(ic r)-22(uptur)-23.9(es of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(on w)-12(all f)16(ar fr)-32(om )]TJ 0.075 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (tumor. )Tj /T1_2 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC [(the N.I. Pirogov N)17.9(ational Medical and Surgical )]TJ 0 Tw T* (Center)Tj /T1_1 1 Tf 0.165 Tw [(. 2022;17$3$:148\226149$In Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.25881/20728255_2)Tj T* (022_17_3_148)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC 4.108 0 Td [(\222.\202., )0.5(\204\031\030\026\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.233 0 Td [(\230.\230., )0.5(\225\031\001\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.717 0 Td [(\210.\230., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.148 0 Td [(\f\024\026\r\021. )0.5(\025\026\004\036\f\021\r\024 )]TJ 0.146 Tw -21.002 -1.25 Td (\032\017\027\017 \023\026\006\017\036\027\021\024\r \023\024\f\035\036 \ \030\026\f\001\017\030\036\027\027\024\005 \035\017\n\235\024\007\017\f\f\ \036\022\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036)Tj 0 Tw (-)Tj 0.005 Tc 0.349 Tw T* (\030\026\006\017\016\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \024\002\024\007\024\004\027\024\ \005 \022\017\001\022\017. )Tj /T1_2 1 Tf -0.005 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.005 Tc 0.35 Tw T* [(2021;20$2$:17\22628. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2021-20-2-17-28)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.355 Tw ( /)Tj 0.064 Tw T* [(S)-16(hel)35(ygin Y)35.1(u)40(.A., Mur)-33(a)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (I.I., Sushkov)Tj /Span<>> BDC ( )Tj EMC [(O.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-15.9(ual)-31(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(ife af)-28(ter )]TJ 0.148 Tw T* [(e)-18(xtended )0.6(l)35(ym)10(ph )0.6(node )0.5(dissec)-16(t)-31.9(ion )0.5(for )0.6(col)30(on )0.6(cancer. )]TJ /T1_2 1 Tf 0 Tw 21.192 0 Td [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf (. )Tj 0.18 Tw -21.192 -1.25 Td [(2021;20$2$:17\22628. $In Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2021-20-)Tj T* (2-17-28)Tj 0 0 0 1 k /GS1 gs 0.292 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Muld)-16(o)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(RL. Mal)-30.9(ignant L)-32(ar)-32(ge Bo)-14(wel Obstr)-21.9(uc)-16(t)-32(ion. )]TJ /T1_2 1 Tf (Clin Colon )Tj 0.023 Tw -1.796 -1.25 Td [(R)21(ectal Surg.)]TJ /T1_1 1 Tf [( 2021 Jul;34$4$:251\226261. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/s-0041-1729922)Tj 0 0 0 1 k /GS1 gs 0.021 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Manceau)Tj /Span<>> BDC ( )Tj EMC (G, Mege)Tj /Span<>> BDC ( )Tj EMC [(D, Br)-37(id)-16(oux)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(r)-23.9(ench sur)-31.9(gical asso)-16(c)-24(ia)15(t)-32(ion )]TJ 0.136 Tw -1.796 -1.25 Td [(w)-14(or)-23.9(k)-16(ing gr)-32(oup. Emer)-32(gency sur)-31.9(ger)-24(y for obstr)-22(uc)-16(t)-31.9(i)-16(ve col)30(on cancer in )]TJ -0.039 Tw T* [(elder)-30(l)35(y )0.5(p)32(a)15(t)-32(ients: )0.6(r)-24(esul)56(ts )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.557 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 0.657 0 Td [(mul)56(t)-32(icentr)-36.9(ic )0.5(cohor)-22(t )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 8.988 0 Td [(t)-13(he )0.5(F)10(r)-24(ench )0.5(na)15(t)-32(ion)]TJ 0 Tw (-)Tj 0.058 Tw -20.202 -1.25 Td [(al sur)-31.9(gical asso)-16(c)-24(ia)15(t)-31.9(ion. )]TJ /T1_2 1 Tf [(Dis Colon )0.5(R)21(ectum)]TJ /T1_1 1 Tf [(. 2019 A)10.1(ug;62$8$:941\226951. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/DCR.0000000000001421)Tj 0 0 0 1 k /GS1 gs 0.106 Tw -1.847 -1.25 Td (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(GBD )0.6(2017 )0.5(Col)30(or)-23.9(ec)-16(t)15(al )0.6(Cancer )0.6(Coll)-16(abor)-33(a)15(t)17(or)-9.9(s. )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 19.356 0 Td [(gl)30(obal, )0.6(r)-24(egional, )]TJ 0.173 Tw -21.152 -1.25 Td [(and na)15(t)-32(ional bur)-24(den of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-16(t)15.1(al cancer and i)-24(ts a)15(t)-30(tr)-36.9(ibut)15(able r)-37(isk )]TJ 0.001 Tc 0.349 Tw T* [(f)16.3(a)-16.8(c)-15.7(t)17.3(or)-9.7(s in 195 countr)-36.7(ies and ter)-23.7(r)-36.7(i)-23.7(t)17.3(or)-36.7(ies, 1990-2017: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.8(stem)]TJ 0 Tc 0 Tw (-)Tj 0.177 Tw T* [(a)15(t)-32(ic anal)35(y)-13(sis for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Gl)30(obal Bur)-23.9(den of)]TJ /Span<>> BDC ( )Tj EMC [(Disease S)15(tud)17(y 2017. )]TJ /T1_2 1 Tf 0 Tw (Lancet )Tj 0.01 Tc 0.362 Tw T* (Gastroenterol Hepatol.)Tj /T1_1 1 Tf [( 2019 Dec;4$12$:913\226933. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1016/)Tj 0 Tc 0 Tw T* (S2468-1253$19$30345-0)Tj 0 0 0 1 k /GS1 gs 0.019 Tc 0.69 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.872 0 Td [(K)-16(alev)]TJ /Span<>> BDC ( )Tj EMC [(G, Mar)-32(quar)-24(d)16.9(t)]TJ /Span<>> BDC ( )Tj EMC [(C, S)-24(chiedeck)]TJ /Span<>> BDC ( )Tj EMC [(T. S)15(t)16.9(omaassozi)-16(ier)-22(te)19( )]TJ 0.009 Tc 0.35 Tw -1.872 -1.25 Td [(K)24.9(om)9.9(pl)-31.1(ik)-17.1(a)14.8(t)-32.1(ionen)]TJ /Span<>> BDC ( )Tj EMC [(\227 V)29.8(er)-16.1(meidungsstr)-33.1(a)14.8(tegie )0.5(und T)46.9(her)-33.1(apiekonzepte)9( )]TJ 0 Tc 0.012 Tw T* [([S)15(t)17(oma-asso)-15.9(c)-24(ia)15(ted com)9.9(pl)-30.9(ica)15(t)-32(ions-P)35(r)-23.9(event)-32(ion str)-33(a)15(teg)16(y and tr)-24(ea)15(tment )]TJ 0 Tw T* (concepts]. )Tj /T1_2 1 Tf 4.531 0 Td (Chirurg.)Tj /T1_1 1 Tf 0.029 Tw [( 2022 Ap)25(r;93$4$:415\226426. Ger)-16(man. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/)Tj -4.531 -1.25 Td (s00104-021-01438-1)Tj 0 0 0 1 k /GS1 gs 0.187 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gov)-15(aer)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(J)15.1(A, F)-19(io)-15.9(cco)]TJ /Span<>> BDC ( )Tj EMC [(M, v)-15(an Dijk)]TJ /Span<>> BDC ( )Tj EMC [(W)31(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al.; Dutch V)25(al)35(ue Based )]TJ 0.029 Tw -1.796 -1.25 Td [(Heal)56(t)-12.9(hcar)-24(e S)15(tud)17(y G)20(r)-32(oup. Costs of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-31.9(ions af)-28(ter col)30(or)-24(ec)-16(t)15(al can)]TJ 0 Tw (-)Tj 0.088 Tw T* [(cer sur)-32(ger)-23.9(y in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Ne)-12(t)-12.9(her)-30(l)-16(ands: Building t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (business case for hos)Tj 0 Tw (-)Tj T* [(pi)-24(t)15(als)]TJ /T1_2 1 Tf 0.14 Tw (. Eur J Surg Oncol)Tj /T1_1 1 Tf [(. 2015 A)10(ug;41$8$:1059\22667. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ejso.2015.03.236)Tj 0 0 0 1 k /GS1 gs 0.005 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Goldsbur)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(DE, F)10(ele)-12(t)-30(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(E, W)22(eber)]TJ /Span<>> BDC ( )Tj EMC [(MF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Heal)56(t)-13(h sy)-13(stem costs and )]TJ 0.111 Tw -1.796 -1.25 Td [(d)42(a)15(y)-13(s )0.5(in )0.5(hospi)-24(t)15(al )0.5(for )0.5(col)30(or)-23.9(ec)-16(t)15(al )0.5(cancer )0.5(p)32(a)15(t)-32(ients )0.5(in )0.5(New )0.5(S)-16(out)-13(h )0.5(W)12(ales, )]TJ 0 Tw T* [(A)10(ustr)-32.9(al)-31(ia. )]TJ /T1_2 1 Tf 0.13 Tw 4.305 0 Td (PLoS One. )Tj /T1_1 1 Tf [(2021 N)-14(ov 29;16$11$:e0260088. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1371/)Tj -4.305 -1.25 Td [(jour)-15(nal.pone.0260088)]TJ 0 0 0 1 k /GS1 gs -0.036 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Meisner)Tj /Span<>> BDC ( )Tj EMC [(S, L)35(ehur)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A, M)-23.9(or)-33(an)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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\220\022\f\021\030\036\027\027\024\020\024 \b\017\ \030\031\030)Tj 0 Tw (-)Tj 0.111 Tw T* (\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \030\026\ \022\026 \035\036\r\024\005 \023\024\035\024\r\017\027\t \024\002\024\007\ \024\004\027\024\005 )Tj 0.424 Tw T* (\022\017\001\022\017, \024\f\035\024\032\027\036\027\027\024\020\024 \024\ \f\021\030\024\005 \022\017\001\036\004\027\024\005 \027\036\023\030\024\ \b\024)Tj 0 Tw (-)Tj 0.108 Tw T* (\007\017\n\024\f\021\034\033 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\032\017\035\024\020\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024)Tj 0 Tw (-)Tj 0.177 Tw T* (\030\026\f\021\026, \n\024\020\031\021 \002\t\021\034 \n\036\021\024\007\ \t \r\030\036\n\036\027\027\024\005 \007\036\022\024\n\023\030\036\f\f\017\ \017 )Tj 0.195 Tw T* (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017. \215\024\022\026\ \026\027\024 \023\030\036\017\n\031\013\036\f\021\r\024 \235\024\030\n\017\ )Tj 0 Tw (-)Tj 0.353 Tw T* (\030\024\r\026\027\017\016 \007\036\022\024\n\023\030\036\f\f\017\024\027\ \027\024\005 \022\024\035\024\f\021\024\n\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n )Tj 0.018 Tw T* (\220\022\f\021\030\036\027\027\024\n \220\021\026\023\036 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \024\002\f\021\030\031\022\021\017\r\027\024\ \020\024 \030\026\022\026 \035\036)Tj 0 Tw (-)Tj -0.046 Tw T* (\r\024\005 \023\024\035\024\r\017\027\t \024\002\024\007\024\004\027\024\ \005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\032\017\035\024)Tj 0 Tw (-)Tj -0.028 Tw T* (\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026. \212\ \026\027\027\t\005 \023\024\007\b\024\007 \031\n\036\027\034\001\026\036\ \021 )Tj 0.234 Tw T* (\023\036\030\017\024\023\036\030\026\006\017\024\027\027\031\033 \035\036\ \021\026\035\034\027\024\f\021\034, \031\035\031\004\001\026\036\021 \022\ \026\004\036\f\021\r\024 )Tj 0.336 Tw T* (\032\017\027\017 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \f\027\017\032\036\027\017\016 \023\024\021\030\036\002\027\ \024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\024\016\027)Tj 0 Tw (-)Tj 0.145 Tw T* (\027\t\b \f\021\024\n\026\b, \024\002\036\f\023\036\004\017\r\026\036\021\ \035\031\004\001\031\033 3-\035\036\021\027\033\033 \024\002\013\031\033\ )Tj 0 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\034.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\226\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.473 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf -0.029 Tc 0.502 Tw [( \246)-18.2(\037)-28.1(\016)-22.4(\036)-26.9(\037)]TJ /Span<>> BDC 19.664 0 Td ( )Tj EMC [(\002)-31.1(.\222.)-21.2(,)-29( )]TJ 0 Tc 0 Tw -19.664 -1.218 Td [(\204)8.3(\017)15.4(\033\034)5.3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\213)-2.3(.)29.4(\231)122(.)]TJ /T1_0 1 Tf T* [(\225)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.8(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf [( \204)8.4(\017)15.3(\033\034)5.3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\213)-2.3(.)29.3(\231)122(.)]TJ /T1_0 1 Tf 0.018 Tc -0.018 Tw T* [(\225)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 11.349 0 Td [( \246)10.8(\037)0.9(\016)6.6(\036)2.1(\037)]TJ /Span<>> BDC ( )Tj EMC [(\002)-2.1(.)29.3(\222)28.8(.)7.8(, \204)8.3(\017)15.4(\033\034)5.3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\213)-2.2(.)29.3(\231)122(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -11.349 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \246)10.8(\037)0.9(\016)6.6(\036)2.1(\037)]TJ /Span<>> BDC ( )Tj EMC [(\002)-2.1(.)29.3(\222)28.8(. \204)8.3(\017)15.4(\033\034)5.3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\213)-2.2(.)29.3(\231)122(.)]TJ /T1_0 1 Tf 15.55 43.841 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf -0.029 Tc 0.029 Tw [( \246)-18.2(\037)-28.1(\016)-22.4(\036)-26.9(\037)]TJ /Span<>> BDC 10.036 0 Td ( )Tj EMC [(\002)-31.1(.\222.)-21.2(,)-29( \215)-20.2(\034)-18.9(\027)-21.8(\032)-18.8(\020)-25.2(\016)-26.3(\006)]TJ /Span<>> BDC 5.757 0 Td ( )Tj EMC [(\216)-4(.\235.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -15.793 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.003 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.4(c)1.8(h)4.8(a)-4.5(e)-4(v)10.8(a)-14(, )]TJ 0 Tw 0 -1.218 TD [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(E)30.3(f)-24.2(r)2.5(on)]TJ /T1_0 1 Tf 1.014 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(E)30.3(f)-24.2(r)2.5(on)]TJ /T1_0 1 Tf -0.007 Tc 1.074 Tw 0 -1.218 TD [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.8(g)1.9(:)]TJ /T1_3 1 Tf 0 Tc 1.067 Tw 10.155 0 Td [( S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.8(n)4.9(a)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.4(c)1.8(h)4.8(a)-4.5(e)-4(v)10.8(a)-14(, )]TJ 0 Tw -10.155 -1.218 Td [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(E)30.3(f)-24.2(r)2.5(on)]TJ /T1_0 1 Tf 0.907 Tw T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.1(:)]TJ /T1_3 1 Tf [( S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.4(c)1.8(h)4.8(a)-4.5(e)-4(v)10.8(a)-14(, )]TJ 0 Tw T* [(A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.3(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(E)30.3(f)-24.2(r)2.5(on)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.415 Tw 3.238 0 Td [( S)16.7(v)6.6(e)-4.4(tl)3.3(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.4(c)1.8(h)4.8(a)-4.5(e)-4(v)10.8(a)-14(, A)3.6(l)4.8(ek)-17.5(s)7.8(a)-0.8(n)-0.6(d)5.2(r)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(E)30.3(f)-24.2(r)2.4(o)0.5(n)-6(, )]TJ 0 Tw -3.238 -1.218 Td [(L)-4.6(ar)-35.3(i)11.1(s)7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(V)23(o)-1.1(l)11(yn)1.9(e)-4.4(t)-29.1(s)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\222 \017\225 \032\026\020\017\022\032\233 $\ ORCID$)Tj /T1_0 1 Tf -0.017 Tw 0 -1.218 TD [(\236\026\036\r\026 )0.5(\225\r\036\021\035\026\027\026 )0.5(\203\017\022\024\035\026\036\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 11.979 0 Td [(\227 )0.5(\007.\n.\027., )0.6(\007\024\006\036\027\021 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 8.374 0 Td (\f\023\036)Tj 0 Tw (-)Tj 0.216 Tw -20.353 -1.218 Td (\006\017\026\035\034\027\024\f\021\017 \253\216\017\030\031\030\020\017\016\ \273, \026\r\036\007\031\033\013\026\016 \022\026\235\036\007\030\024\005\ \235\026)Tj 0 Tw (-)Tj 0.176 Tw T* (\022\031\035\034\021\036\021\f\022\024\005 \b\017\030\031\030\020\017\017\ \205\206\207\210\211 \200\210 \253\225\n\024\035\036\027\f\022\017\005 \ \020\024\f\031)Tj 0 Tw (-)Tj 0.139 Tw T* (\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\022\017\ \005 \031\027\017\r\036\030\f\017\021\036\021\273 \204\017\027\007\030\026\ \r\026 )Tj -0.021 Tw T* (\217\024\f\f\017\017; \r\030\026\004-\b\017\030\031\030\020, \024\027\022\ \024\035\024\020 \204\027\024\020\024\023\030\024\235\017\035\034\027\024\ \005 \022\035\017)Tj 0 Tw (-)Tj T* (\027\017\022\017 \210\210\210 \253\211\030\024\n\036\007\273; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-1832-5255)Tj -0.01 Tw T* (\237\235\030\024\027 \202\035\036\022\f\026\027\007\030 \206\030\017\020\ \024\030\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 )Tj 0.078 Tw T* (\203\230\037 \205\206\207\210\211 \200\210 \253\225\n\024\035\036\027\f\022\ \017\005 \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\ \017)Tj 0 Tw (-)Tj 0.237 Tw T* (\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021\273 \ \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; \020\035\026\r\027\ \t\005 )Tj 0.093 Tw T* (\r\030\026\004 \210\206\207\211\003 \253\225\n\024\035\036\027\f\022\017\ \005 \024\002\035\026\f\021\027\024\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 )Tj 0 Tw T* (\022\035\017\027\017\004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030\ \273)Tj 0.004 Tc 0.377 Tw T* (\200\024\035\t\027\036\006 \214\026\030\017\f\026 \230\f\026\022\024\r\027\ \026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 1.151 Tw T* [(\235\036\007\030\t \235\026\022\031\035\034\021\036\021\f\022\024\005 \b\ \017\030\031\030\020\017\017 \205\206\207\210\211 \200\210)4( )]TJ 0.454 Tw T* [(\253\225\n\024\035\036\027\f\022\017\005 )0.5(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 )0.5(\031\027\017)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.215 Tw T* [(\r\036\030\f\017\021\036\021\273 \204\017\027\007\030\026\r\026 \217\024\ \f\f\017\017; \020\035\026\r\027\t\005 \r\030\026\004 \210\206\207\211\003\ )4( )]TJ 0.588 Tw T* [(\253\225\n\024\035\036\027\f\022\026\016 \024\002\035\026\f\021\027\026\016\ \022\035\017\027\017\004\036\f\022\026\016 \002\024\035\034\027\017\006\ \026\273;)4.1( )]TJ 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0001-8351-9163)Tj /T1_2 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS $ORCID$)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(Sve)-12(tl)-15.9(ana N. S)-16(hchaev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1832-5255)Tj T* [(Alek)-10(sandr G. Efr)-31.8(on)]TJ T* [(L)-32(ar)-37(isa I. V)29.1(ol)35(yne)-12(ts)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8351-9163)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 249.8879 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.283 Tw 8 0 0 8 70.8661 237.0532 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Biond)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(S, G\341l)30(vez)]TJ /Span<>> BDC ( )Tj EMC [(A, R)-9.9(am\355r)-24(ez)]TJ /Span<>> BDC ( )Tj EMC [(E. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Emer)-31.9(gency sur)-32(ger)-24(y for )]TJ 0.028 Tw -1.296 -1.25 Td [(obstr)-22(uc)-15.9(t)-32(ing and per)-24(for)-32.9(a)15(ted col)30(on cancer: p)32(a)15(t)-30(ter)-15(ns of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ecur)-24(r)-24(ence and )]TJ 0.209 Tw 0 -1.25 TD [(p)25(r)-32(o)-16(gnost)-32(ic f)16(a)-16.9(c)-16(t)17(or)-10(s. )]TJ /T1_3 1 Tf [(T)54(ech Colop)46(roctol.)]TJ /T1_0 1 Tf ( 2019 Dec;23$12$:1141\2261161. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s10151-019-02110-x)Tj 0 0 0 1 k /GS1 gs 0.132 Tw -1.847 -1.25 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC (H, Jin)Tj /Span<>> BDC ( )Tj EMC [(Y, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(shor)-22(t-ter)-15.9(m sur)-32(gical )]TJ 0.135 Tw -1.296 -1.25 Td [(outcomes and l)30(ong-ter)-16(m sur)-32(v)-16(i)-15.9(v)-15(al be)-12(t)-32(ween emer)-32(gency and elec)-16(t)-32(i)-16(ve )]TJ -0.003 Tw T* [(sur)-32(ger)-23.9(y for col)30(or)-24(ec)-15.9(t)15(al cancer: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew and me)-11.9(t)15(a-anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0.217 Tw T* [(Int )0.5(J )0.5(Colorectal )0.6(Dis)]TJ /T1_0 1 Tf [(. )0.5(2023 )0.5(F)10(eb )0.5(15;38$1$:41. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.658 0 Td (10.1007/s00384-)Tj -20.658 -1.25 Td (023-04334-8)Tj 0 0 0 1 k /GS1 gs 0.201 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Danzi)Tj /Span<>> BDC ( )Tj EMC [(M, G)20(r)-36.9(imaldi)]TJ /Span<>> BDC ( )Tj EMC (L, De Capua)Tj /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Obstr)-22(uc)-15.9(t)-32(ing lef)-28(t sided )]TJ 0.047 Tw -1.296 -1.25 Td [(col)30(or)-24(ec)-15.9(t)15(al cancer. A)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(e)-12(tr)-32(ospec)-16(t)-32(i)-16(ve single Center stud)17(y. )]TJ /T1_3 1 Tf (Ann Ital Chir. )Tj /T1_0 1 Tf 0.023 Tw T* (2019;90:121\226126. PMID: 30569909.)Tj 0.013 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Kr)-32(onbor)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(O. A)-25(cute obstr)-21.9(uc)-16(t)-32(ion fr)-32(om tumor in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(lef)-28(t col)30(on wi)-23.9(t)-13(h)]TJ 0 Tw (-)Tj 0.003 Tw -1.296 -1.25 Td [(out sp)25(r)-24(ead. 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)]TJ 0.378 Tw T* (\030\017\f\022 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 \202\n\036\030\017\022\026\ \027\f\022\024\020\024 \024\002\013\036\f\021\r\026)2( )]TJ 0.173 Tw T* (\026\027\036\f\021\036\017\024\035\024\020\024\r, \f\021\026\007\017\016\ \026\002\024\035\036\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.02 Tw T* (\006\017\024\027\027\t\036 \024\f\035\024\032\027\036\027\017\016, \024\022\ \026\t\r\026\033\013\017\036 \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\r\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.546 Tw T* [(\035\017\004\036\027\017\036 \004\026\f\021\024\021\t \024\f\035\024\032\ \027\036\027\017\005, \027\036\f\024\f\021\024\016\021\036\035\034\027\024\ \f\021\034)2( )]TJ 0.26 Tw T* (\026\027\026\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\036\036 \r\t\f\024\022\017\005 \031\030\024\r\036\027\034 \035\ \036\021\026\035\034\027\024\f\021\017)2( )]TJ -0.002 Tw T* ([6,7,21,28,33].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 274.2439 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.016 Tw 10 0 0 10 274.9606 249.8879 Tm (\211\f\021\026\027\024\r\035\036\027\024, \004\021\024 \021\017\023 \030\ \036\036\022\006\017\017 \021\024\035\f\021\024\005 \022\017\001\022\017\ \r\035\017\016\036\021 )Tj 0.179 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007. \203\036\f\022\024\035\034\022\024 \017\f\f\035\036\007\ \024\r\026\027\017\005 \023\024\022\026\026\035\017 \002\024\035\036\036\ )Tj 0.154 Tw T* (\r\t\f\024\022\031\033 \004\026\f\021\024\021\031 \027\036\f\024\f\021\024\ \016\021\036\035\034\027\024\f\021\017 \026\027\026\f\021\024\n\024\026\ \023\024)Tj 0 Tw (-)Tj 0.023 Tw T* [(\f\035\036 \035\036\r\024\f\021\024\030\024\027\027\036\005 \030\036\036\ \022\006\017\017 )0.5(\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.255 Tw T* [(\f\024\022\017\036 \023\024\022\026\026\021\036\035\016\n\017 )0.5(\035\036\021\026\035\034\027\024\f\021\017 [2,25,45]. \216\031\007\001\017\ \005 )]TJ 0.268 Tw T* (\017\f\b\024\007 \220\022\f\021\030\036\027\027\024\005 \b\017\030\031\030\ \020\017\017 \n\024\032\036\021 \024\002\255\016\f\027\016\021\034\f\016\ \027\036 )Tj 0.036 Tw T* (\021\024\035\034\022\024 \023\035\024\b\017\n \023\030\036\007\024\023\036\ \030\026\006\017\024\027\027\t\n \f\024\f\021\024\016\027\017\036\n \023\ \026\006\017)Tj 0 Tw (-)Tj 0.119 Tw T* (\036\027\021\024\r, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \004\021\024 \220\022\f\021\030\036\027\027\024\036 \b\017\030\ \031\030\020\017\004\036\f\022\024\036 \r\n\036)Tj 0 Tw (-)Tj 0.204 Tw T* [(\001\026\021\036\035\034\f\021\r\024 )0.5(\004\026\f\021\024 \023\030\024\r\024\007\017\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\r\036\004\036\030\027\036\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\027\024\004\027\024\036 )Tj 0.009 Tw T* (\r\030\036\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\024\020\007\026 \b\017\030\031\030\020\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\017\n \024\023\t\021\024\n \030\026\002\024\021\t )Tj 0.002 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\t\n\017 \026\002\024\035\036\r\026\027\ \017\016\n\017. \224\026\022\017\n \024\002\030\026\024\n, \027\036\024\ \021)Tj 0 Tw (-)Tj 0.128 Tw T* (\035\024\032\027\026\016 \024\023\036\030\026\006\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \024\002\024\007\024\004\027\024\ \005 \022\017\001\022\017 )Tj 0.142 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 \f\021\036\023\036\027\017 \f\r\016\026\027\ \026 \f)Tj /Span<>> BDC ( )Tj EMC (\026\007\036\022\r\026\021\027\t\n \035\036\004\036\027\017\036\n )Tj 0.226 Tw T* [(\024\f\035\024\032\027\036\027\017\016, )0.5(\021\026\022\024\020\024 \022\026\022 \022\017\001\036\004\027\026\016 )0.5(\027\036\023\030\024\b\024\007\017\n\024\f\021\034, )]TJ 0.151 Tw T* [(\023\024\f\022\024\035\034\022\031 )0.6(\030\036\004\034 )0.5(\017\007\036\021 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC 9.993 0 Td [(\f\024\002\035\033\007\036\027\017\017 )0.6(\024\027\022\024\035\024\020\017\004\036\f\022\017\b )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.085 Tw 9 0 0 9 42.5197 730.483 Tm [(\020\004\206\f\t\204\004 )0.5(2.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(\201\034\024\027\016\034\f\016\033\037\006\022\034\020\020\032\016 )0.5(\034\024\027\034\003\020\016\020\022\030 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 19.706 0 Td [(\027\016\035\037\027\007\020\034\024\035\007 )0.6(\f\034\024\027\016 )0.6(\220\021\024\035\033\016\020\020\032\001 )0.6(\033\016\031\016\021\006\022\034\020\020\032\001 )0.6(\036\b\016\004\037\035\016\027\007\024\035\036 )0.5(\f\034)]TJ /Span<>> BDC ( )Tj EMC 27.835 0 Td (\f\034\036\034\005\023 )Tj 0 Tw -47.541 -1.2 Td (\033\037\021\037 \034\025\034\005\034\n\020\034\t \021\022\004\021\022 \023\ )Tj /Span<>> BDC ( )Tj EMC (\f\037\006\022\016\020\035\034\036 \f\034\003\022\027\034\013\034 \022)Tj /Span<>> BDC ( )Tj EMC (\024\035\037\033\n\016\024\021\034\013\034 \036\034\031\033\037\024\035\037\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.001 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc -0.026 Tw 3.307 0 Td [( P)20.2(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.4(a)-9.2(t)-29.1(i)-2.9(v)2.3(e c)2.8(o)-4(m)-1(p)-4.9(li)-1.7(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-5.1(n)-4.8(d m)-5.3(o)-3(r)-41.9(t)-1.9(a)-4.5(li)-3.4(t)-33.8(y a)-0.6(f)-50.9(t)-1.6(e)-6(r e)-7(m)-5.3(e)-5.9(r)-2(g)-6.8(e)-7(n)-2.9(c)-32.4(y r)-2(e)-22(s)0.5(e)-10.9(c)-32.4(t)-29.1(i)-1.4(o)-3.9(n i)3.9(n)-0.6(t)-1.6(e)-6(r)-42.9(v)2.3(e)-7(n)-0.6(t)-29.1(i)-1.4(o)-4(n)3.7(s f)-13.4(o)-2.9(r c)2.8(o)-5.3(l)-1.6(o)-4(n c)3.2(a)-5.1(n)-2.9(c)2.8(e)-6(r i)4(n e)-6.1(l)-3.9(d)-5.3(e)-6(r)-10.1(l)6.6(y a)-5.1(n)-4.8(d s)0.5(e)-7(n)1.7(i)2.9(le )]TJ 0.001 Tc -0.001 Tw -3.307 -1.2 Td [(p)-5.3(a)-8.2(t)-28.1(ie)-6(nt)-31.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 99.4626 693.581 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 150.4862 693.581 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 184.502 693.581 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 238.3602 693.581 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 326.2343 693.581 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 414.1083 693.581 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 496.313 647.8925 cm 0 0 m 0 45.439 l S Q q 1 0 0 1 42.5197 647.6425 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 99.4626 647.6425 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 150.4862 647.6425 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 184.502 647.6425 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 238.3602 647.6425 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 326.2343 647.6425 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 414.1083 647.6425 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 496.313 621.1619 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 42.5197 620.9119 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 99.4626 620.9119 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 150.4862 620.9119 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 184.502 620.9119 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 238.3602 620.9119 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 326.2343 620.9119 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 414.1083 620.9119 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 496.313 565.6313 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 42.5197 565.3813 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 99.4626 565.3813 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 150.4862 565.3813 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 184.502 565.3813 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 238.3602 565.3813 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 326.2343 565.3813 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 414.1083 565.3813 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 496.313 529.3008 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 42.5197 529.0508 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 99.4626 529.0508 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 150.4862 529.0508 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 184.502 529.0508 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 238.3602 529.0508 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 326.2343 529.0508 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 414.1083 529.0508 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 496.313 483.3702 cm 0 0 m 0 45.431 l S Q q 1 0 0 1 42.5197 483.1202 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 99.4626 483.1202 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 150.4862 483.1202 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 184.502 483.1202 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 238.3602 483.1202 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 326.2343 483.1202 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 414.1083 483.1202 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 496.313 456.6396 cm 0 0 m 0 26.231 l S Q q 1 0 0 1 42.5197 456.3896 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 99.4626 456.3896 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 150.4862 456.3896 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 184.502 456.3896 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 238.3602 456.3896 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 326.2343 456.3896 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 414.1083 456.3896 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 496.313 420.309 cm 0 0 m 0 35.831 l S Q q 1 0 0 1 42.5197 420.059 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 99.4626 420.059 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 150.4862 420.059 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 184.502 420.059 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 238.3602 420.059 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 326.2343 420.059 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 414.1083 420.059 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 496.313 355.1785 cm 0 0 m 0 64.631 l S Q q 1 0 0 1 42.5197 354.9285 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 99.4626 354.9285 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 99.4626 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 150.4862 354.9285 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 150.4862 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 184.502 354.9285 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 184.502 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 238.3602 354.9285 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 238.3602 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 326.2343 354.9285 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 414.1083 354.9285 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 414.1083 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 496.313 299.6479 cm 0 0 m 0 55.031 l S Q q 1 0 0 1 42.5197 299.3979 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 99.4626 299.3979 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 150.4862 299.3979 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 184.502 299.3979 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 238.3602 299.3979 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 326.2343 299.3979 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 414.1083 299.3979 cm 0 0 m 82.455 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 46.0486 672.5118 Tm (\032\003\002\006, \217\003\006\004\b\004,)Tj 2.403 -1.2 Td (\n\002\240)Tj 5.268 2.4 Td (N \212\004\204\t\r\b)Tj (-)Tj -0.112 -1.2 Td (\003\002, \220\f\211)Tj (-)Tj -0.493 -1.2 Td (\201\r\b\b\013\216 )Tj /Span<>> BDC ( )Tj EMC (\t\217)Tj (-)Tj 0.24 -1.2 Td (\217\f\r\240\002\004\b\t\r)Tj 6.656 3 Td (\255\006\r\240)Tj (-)Tj 0.393 -1.2 Td (\b\t\005 )Tj -0.843 -1.2 Td (\002\213\006\004\217\003)Tj 4.832 1.8 Td (\200\002\220\004\213\004\b\t\235 )Tj -0.15 -1.2 Td (\220)Tj /Span<>> BDC ( )Tj EMC (\002\212\r\006\004\204\t\t)Tj 6.786 1.2 Td (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\013\r )Tj 1.865 -1.2 Td (\002\217\f\002\202\b\r\b\t\235)Tj 8.959 1.8 Td (30-\003\t \240\b\r\b\004\235 \212\002\217\f\r)Tj (-)Tj 1.587 -1.2 Td (\002\212\r\006\004\204\t\002\b\b\004\235)Tj 0.452 -1.2 Td (\f\r\003\004\f\001\b\002\217\003\001)Tj 9.007 3 Td (\203\004\220\003\002\006\013 \006\t\217\220\004, \b\r)Tj (-)Tj 0.159 -1.2 Td (\206\f\004\n\002\212\006\t\235\003\b\002 \f\t)Tj (-)Tj 0.185 -1.2 Td (\235\211\223\t\r \b\004)Tj /Span<>> BDC ( )Tj EMC (\212/\002\212\r\006. )Tj 1.278 -1.2 Td (\f\r\003\004\f\001\b\002\217\003\001)Tj /T1_1 1 Tf -48.529 -2.141 Td (Mothes [42], )Tj T* (\206\036\030\n\026\027\017\016, 2017)Tj 9.421 1.2 Td (33)Tj 4.948 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (80)Tj 4.01 0 Td (\203\036 \031\022\026\026\027\t)Tj 8.858 0 Td (\203\036 \031\022\026\026\027\t)Tj 12.453 0 Td (36%)Tj 8.743 0 Td (\200\024\030\026\f\021)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (80; )Tj 0.17 -1.2 Td (Charlson)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (2.)Tj -48.604 -2.141 Td (Tabola [43], )Tj T* (\206\036\030\n\026\027\017\016, 2017)Tj 9.421 1.2 Td (32)Tj 4.972 0 Td (75,5)Tj /T1_4 1 Tf 5.102 0 Td (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (20 )Tj -1.052 -1.2 Td (\210\224\025\203, )Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8 )Tj -0.356 -1.2 Td (\023\036\030\235\024\030\026\006\017\016, )Tj /T1_4 1 Tf 1.659 -1.2 Td (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4 )Tj -1.878 -1.2 Td (\022\030\024\r\024\021\036\004\036\027\017\016)Tj 10.84 4.8 Td (28%)Tj 10.642 0 Td (12,5%)Tj 7.112 0 Td (\203\036 \r\t\016\r\035\036\027\024 \235\026\022\021\024\030\024\r )Tj 1.221 -1.2 Td (\f\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj -0.675 -1.2 Td (\027\026\004\017\n\t\n \r\035\017\016\027\017\036\n)Tj -47.008 -4.541 Td (De Simone [44], )Tj 0 -1.2 TD (\230\021\026\035\017\016, 2017)Tj 9.421 1.2 Td (19)Tj 4.972 0 Td (92,5)Tj /T1_4 1 Tf 5.102 0 Td (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (14 )Tj -1.052 -1.2 Td (\210\224\025\203, )Tj /T1_4 1 Tf (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5 )Tj -0.412 -1.2 Td (\023\036\030\235\024\030\026\006\017\016.)Tj 10.676 2.4 Td (37%)Tj 10.984 0 Td (21%)Tj 8.899 0 Td (\200\024\030\026\f\021)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (80)Tj -48.59 -4.541 Td (Schlichtemeier )Tj 0 -1.2 TD ([45], )Tj T* (\202\r\f\021\030\026\035\017\016, )Tj T* (2016)Tj 9.421 3.6 Td (62)Tj 5.315 0 Td (91)Tj 3.644 0 Td (\203\036 \031\022\026\026\027\t)Tj 8.858 0 Td (\203\036 \031\022\026\026\027\t)Tj 12.361 0 Td (9,7%)Tj 6.862 0 Td (\203\036 \r\t\016\r\035\036\027\024 \235\026\022\021\024\030\024\r )Tj 1.221 -1.2 Td (\f\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj -0.675 -1.2 Td (\027\026\004\017\n\t\n \r\035\017\016\027\017\036\n)Tj -47.008 -3.341 Td (Pirrera [46], )Tj T* (\230\021\026\035\017\016, 2016)Tj 9.421 1.2 Td (78)Tj 5.315 0 Td (84)Tj 3.644 0 Td (\203\036 \031\022\026\026\027\t)Tj 8.858 0 Td (\203\036 \031\022\026\026\027\t)Tj 12.111 0 Td (15,3%)Tj 9.241 0 Td (\200\024\030\026\f\021)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (80)Tj -48.59 -3.341 Td (Ming-Gao [47], )Tj T* (\025\017\021\026\005, 2014)Tj 9.421 1.2 Td (85)Tj 4.972 0 Td (84,7)Tj /T1_4 1 Tf 3.799 0 Td (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (75 \210\224\025\203, )Tj /T1_4 1 Tf 1.302 -1.2 Td (n)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10 )Tj -1.316 -1.2 Td (\023\036\030\235\024\030\026\006\017\016)Tj 10.186 2.4 Td (71,8%)Tj 10.984 0 Td (30,6%)Tj 7.112 0 Td (\203\036 \r\t\016\r\035\036\027\024 \235\026\022\021\024\030\024\r )Tj 1.221 -1.2 Td (\f\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj -0.675 -1.2 Td (\027\026\004\017\n\t\n \r\035\017\016\027\017\036\n)Tj -47.008 -2.141 Td (Kolfschoten )Tj T* ([48], )Tj 0 -1.2 TD (\206\024\035\035\026\027\007\017\016, )Tj 0 -1.2 TD (2012)Tj 9.171 3.6 Td (268)Tj 5.198 0 Td (>)Tj /Span<>> BDC ( )Tj EMC (80)Tj 4.01 0 Td (\203\036 \031\022\026\026\027\t)Tj 6.343 0 Td (\215\030\017 \027\026\035\017\004\017\017 1 \235\026\022\021\024\030\026\ )Tj 1.905 -1.2 Td (\030\017\f\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 27%;)Tj -2.161 -1.2 Td (\215\030\017 \027\026\035\017\004\017\017 2 \235\026\022\021\024\030\024\ \r )Tj 2.161 -1.2 Td (\030\017\f\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 50%;)Tj -2.161 -1.2 Td (\215\030\017 \027\026\035\017\004\017\017 3 \235\026\022\021\024\030\024\ \r )Tj 2.316 -1.2 Td (\030\017\f\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 77%)Tj 8.923 6 Td (\215\030\017 \027\026\035\017\004\017\017 1 \235\026\022\021\024\030\026\ )Tj 2.155 -1.2 Td (\030\017\f\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 7%;)Tj -2.411 -1.2 Td (\215\030\017 \027\026\035\017\004\017\017 2 \235\026\022\021\024\030\024\ \r )Tj 2.161 -1.2 Td (\030\017\f\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 21%;)Tj -2.161 -1.2 Td (\215\030\017 \027\026\035\017\004\017\017 3 \235\026\022\021\024\030\024\ \r )Tj 2.316 -1.2 Td (\030\017\f\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 41%)Tj 8.939 6 Td (\200\024\030\026\f\021)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (80, ASA)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (3; )Tj 1.393 -1.2 Td (\035\036\r\024\f\021\024\030\024\027\027\016\016 )Tj -0.016 -1.2 Td (\020\036\n\017\022\024\220\022\021\024\n\017\016 )Tj -0.491 -1.2 Td (\017\035\017 \f\031\002\021\024\021\026\035\034\027\026\016 )Tj 1.217 -1.2 Td (\022\024\035\220\022\021\024\n\017\016)Tj -48.81 -3.341 Td (Iversen [49], )Tj 0 -1.2 TD (\212\026\027\017\016, 2008)Tj 8.921 1.2 Td (2157)Tj 5.815 0 Td (74)Tj 3.468 0 Td (73,9% \210\224\025\203, )Tj 1.302 -1.2 Td (21,3% )Tj -1.327 -1.2 Td (\023\036\030\235\024\030\026\006\017\016)Tj 7.881 2.4 Td (\224\036\030\026\023\036\r\021\017\004\036\f\022\017\036 )Tj -1.108 -1.2 Td (\024\f\035\024\032\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 24,4%;)Tj 1.557 -1.2 Td (\216\017\030\031\030\020\017\004\036\f\022\017\036 )Tj -1.401 -1.2 Td (\024\f\035\024\032\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 20,4%)Tj 11.356 3.6 Td (\212\024 80 \035\036\021)Tj /Span<>> BDC ( )Tj EMC (\227 22.1%; )Tj 0.284 -1.2 Td (81\22690 \035\036\021)Tj /Span<>> BDC ( )Tj EMC (\227 35%;)Tj 0.567 -1.2 Td (\250)Tj /Span<>> BDC ( )Tj EMC (91 \035\036\021)Tj /Span<>> BDC ( )Tj EMC (\227 48%)Tj 11.12 2.4 Td (\200\024\030\026\f\021)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (71; )Tj -1.829 -1.2 Td (\n\031\032\f\022\024\005 \023\024\035; ASA)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (3; )Tj 1.571 -1.2 Td (\f\023\035\036\027\220\022\021\024\n\017\016; )Tj -0.462 -1.2 Td (\021\036\030\026\023\036\r\021\017\004\036\f\022\017\036 )Tj 0.961 -1.2 Td (\024\f\035\024\032\027\036\027\017\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 504.7397 56.0378 Tm (141)Tj ET endstream endobj 98 0 obj <> endobj 101 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.051 Tw 10 0 0 10 70.8661 724.8299 Tm (\217\036\032\036 \002\t\035\017 \f\235\024\030\n\017\030\024\r\026\027\t\ \023\024\f\021\024\016\027\027\t\036 \f\021\024\n\t $23,4% )Tj 0.103 Tw 0 -1.218 TD (\023\030\024\021\017\r 42,4%, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.103 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$, \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\017 3-\035\036\021\027\036\005 \024\002\ )Tj 0 Tw (-)Tj 0.002 Tw T* (\013\036\005 \r\t\032\017\r\026\036\n\024\f\021\017 \002\t\035\017 \035\031\ \004\001\036 $79,4% \023\030\024\021\017\r 73,3%, )Tj 0 Tw T* (\024\021\027\024\001\036\027\017\036 \030\017\f\022\024\r 0,36$ [34].)Tj /T1_2 1 Tf 0.167 Tw 0 -2.436 TD (\017\217\002\206\r\b\b\002\217\003\t \216\t\006\210\006\n\t\201\r\217\220\ \002\n\002 \f\r\201\r\b\t\235 \002\217\003\006\002\005 \220\t)Tj 0 Tw (-)Tj 0.026 Tw 0 -1.218 TD (\241\r\201\b\002\005 \b\r\212\006\002\216\002\240\t\214\002\217\003\t \002\ \212\210\216\002\f\r\002\n\002 \n\r\b\r\213\004 \210)Tj /Span<>> BDC ( )Tj EMC (\212\004)Tj 0 Tw (-)Tj 0 -1.218 TD (\204\t\r\b\003\002 \212\002\202\t\f\002\n\002 \t)Tj /Span<>> BDC ( )Tj EMC (\217\003\004\006\201\r\217\220\002\n\002 \002\213\006\004\217\003\004)Tj /T1_0 1 Tf 0.368 Tw T* (\224\036\b\027\024\035\024\020\017\004\036\f\022\017\005 \023\030\024\020\ \030\036\f\f \023\024\f\035\036\007\027\017\b \007\036\f\016\021\017\035\ \036\021\017\005 )Tj 0.583 Tw T* [(\027\026\004\017\021\036\035\034\027\024 )0.5(\030\026\f\001\017\030\017\035 \r\024\n\024\032\027\024\f\021\017 \r)]TJ /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.483 Tw T* (\004\036\f\022\024\n \035\036\004\036\027\017\017 \021\024\035\f\021\024\ \022\017\001\036\004\027\024\005 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\017 )Tj 0.261 Tw T* [(\024\023\031\b\024\035\036\r\024\020\024 )0.6(\020\036\027\036\026. )0.5(\210\007\027\026\022\024 )0.5(\035\036\004\036\027\017\036 )0.6(\024\f\021\030\024\005 )0.6(\035\036\r\024)]TJ 0 Tw (-)Tj 0.14 Tw 0 -1.218 TD (\f\021\024\030\024\027\027\036\005 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\017 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \031\ )Tj /Span<>> BDC ( )Tj EMC (\035\017\006 )Tj 0.033 Tw 0 -1.218 TD (\023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026 \023\024\ -\023\030\036\032\027\036\n\031 \024\f\021\026)Tj 0 Tw (-)Tj -0.031 Tw 0 -1.218 TD [(\036\021\f\016 )0.5(\023\030\024\002\035\036\n\024\005, )0.6(\027\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.101 0 Td [(\027\026\004\017\021\036\035\034\027\t\005 )0.6(\023\030\024\020\030\036\f\f. )]TJ 0.214 Tw -12.101 -1.218 Td (\203\036\031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\t\036\ \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 \030\036\ \031\035\034)Tj 0 Tw (-)Tj 0.237 Tw T* (\021\026\021\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\032\017\035\024\020\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f)Tj 0 Tw (-)Tj 0.255 Tw T* (\021\026 \n\024\020\031\021 \002\t\021\034 \024\002\255\016\f\027\036\027\ \t \027\036\f\022\024\035\034\022\017\n\017 \023\030\017\004\017\027\026\ \n\017, )Tj 0.305 Tw T* [(\r\022\035\033\004\026\016 \017\n\036\027\036\027\027\t\005 \235\017\017\ \004\036\f\022\017\005 )0.5(\f\021\026\021\031\f \023\026\006\017\036\027\021\026 )]TJ 0.084 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\031\013\036\027\027\031\033 \024\023\031\b\024\035\034. \210\002\ \026 \235\026\022\021\024\030\026 \004\026\f\021\024 \r\f\021\031\023\026\ \033\021 )Tj 0.167 Tw T* [(\r\024 )0.5(\r\026\017\n\024\007\036\005\f\021\r\017\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.399 0 Td [(\n\024\020\031\021 )0.5(\r\t\r\026\021\034 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 7.183 0 Td [(\002\024\035\034\027\024\020\024 )0.6(\027\026)]TJ 0 Tw (-)Tj 0.307 Tw -16.583 -1.218 Td (\030\031\001\036\027\017\016 \r\024\007\027\024-\220\035\036\022\021\030\ \024\035\017\021\027\024\020\024 \002\026\035\026\027\f\026, \f\027\017\032\ \036\027\017\036 )Tj 0.261 Tw T* (\n\026\f\f\t \021\036\035\026, \024\002\f\021\030\031\022\006\017\033 \023\ \017\013\036\r\026\030\017\021\036\035\034\027\024\020\024 \021\030\026\022\ \021\026. )Tj 0.289 Tw T* (\025\030\024\n\036 \021\024\020\024, \n\036\021\026\002\024\035\017\004\036\ \f\022\017\036 \027\026\030\031\001\036\027\017\016 \n\024\020\031\021 \r\ \t)Tj 0 Tw (-)Tj 0.449 Tw T* (\r\026\021\034 \024\002\024\f\021\030\036\027\017\036 \f\036\030\007\036\ \004\027\024-\f\024\f\031\007\017\f\021\024\005 \023\026\021\024\035\024\ \020\017\017 )Tj 0.226 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\002\036\021\026. \207\024\035\036\036 \021\024\020\024, \220\ \022\f\021\030\036\027\027\t\036 \024\023\036\030\026\006\017\017 \004\026\ \013\036 )Tj -0.035 Tw T* (\023\030\024\r\024\007\016\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\034\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\024\007\027\036\005 )Tj -0.047 Tw T* (\f\021\026\007\017\017 [32,37,38]. \237\022\f\021\030\036\027\027\026\016\ \023\024\n\024\013\034 \220\021\017\n \024\f\035\026\002\035\036\027)Tj 0 Tw (-)Tj 0.026 Tw T* (\027\t\n \023\026\006\017\036\027\021\026\n \024\f\021\026\036\021\f\016\ \007\024\f\021\026\021\024\004\027\024 \f\035\024\032\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017-\026 )Tj 0.093 Tw T* [(\024\021\f\031\021\f\021\r\017\016 )0.5(\017\027\235\024\030\n\026\006\017\017 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC 16.095 0 Td [(\021\024\004\027\024\005 )0.5(\f\021\026\007\017\017 )]TJ -0.036 Tw -16.095 -1.218 Td (\024\023\031\b\024\035\017. \215\024\220\021\024\n\031 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\n \220\021\026\023\036 \030\026\r\017\ \021\017\016 \b\017)Tj 0 Tw (-)Tj 0.014 Tw T* (\030\031\030\020\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\017 \030\026\f\f\004\017\021\t\r\026\021\ \034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\036 \r\t)Tj 0 Tw (-)Tj 0.061 Tw T* (\f\024\022\017\b \030\036\031\035\034\021\026\021\024\r \035\036\004\036\ \027\017\016 \r\024\n\024\032\027\024 \021\024\035\034\022\024 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\031\f)Tj 0 Tw (-)Tj 0.211 Tw T* (\035\024\r\017\017, \022\024\020\007\026 \b\017\030\031\030\020\017\004\036\ \f\022\026\016 \f\024\f\021\026\r\035\016\033\013\026\016 \035\036\004\036\ \027\017\016 )Tj 0.165 Tw T* (\023\026\006\017\036\027\021\026 \r\t\023\024\035\027\036\027\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\n \031\030\024\r\027\036. \215\026\006\017\036\027\021\ \t )Tj 0.244 Tw T* (\023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026, \f\021\ \030\026\007\026\033\013\017\036 \024\f)Tj 0 Tw (-)Tj 0.12 Tw T* (\035\024\032\027\036\027\027\t\n \030\026\022\024\n \035\036\r\024\005 \023\ \024\035\024\r\017\027\t \024\002\024\007\024\004\027\024\005 \022\017\001\ )Tj 0 Tw (-)Tj 0.024 Tw T* (\022\017, \022\026\022 \023\030\026\r\017\035\024, \023\024\007\027\024\ \024\002\030\026\013\026\033\021\f\016 \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\f\022\024\005 )Tj 0.173 Tw T* [(\023\024\n\024\013\034\033, \022\024\020\007\026 \r\t\030\026\032\036\027\ \027\024\f\021\034 )0.5(\027\036\023\030\024\b\024\007\017\n\024\f\021\017 )0.5(\007\024)]TJ 0 Tw (-)Tj 0.15 Tw T* (\f\021\017\020\026\036\021 \f\031\002- \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\022\024\n\023\036\027\f\017\030\024\r\026\027\027\t\b \f\021\026\ \007\017\005. \003\026\007\026\004\017 )Tj 0.134 Tw T* [(\035\036\004\036\027\017\016 )0.5(\007\026\027\027\t\b )0.5(\002\024\035\034\027\t\b \027\026\023\030\026\r\035\036\027\t )0.5(\022\026\022 \027\026)]TJ /Span<>> BDC ( )Tj EMC 19.453 0 Td (\f\023\026\f\036)Tj 0 Tw (-)Tj 0.148 Tw -19.453 -1.218 Td [(\027\017\036 \032\017\027\017 )0.5(\002\024\035\034\027\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.616 0 Td [(\031\030\020\036\027\021\027\024\005 )0.5(\f\017\021\031\026\006\017\017, )0.5(\021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC 11.52 0 Td (\027\026 )Tj -0.018 Tw -21.136 -1.218 Td (\030\026\007\017\022\026\035\034\027\024\036 \017\035\036\004\036\027\017\ \036 \024\021 \035\024\022\026\004\036\f\021\r\036\027\027\024\020\024 \ \027\024\r\024\024\002)Tj 0 Tw (-)Tj T* (\030\026\024\r\026\027\017\016 [39\22641].)Tj 0.238 Tw T* [(\210\023\036\030\026\006\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\036 )0.5(\f\021\026\035\017 \f\026\n\t\n\017 )0.5(\030\026\f)]TJ 0 Tw (-)Tj 0.591 Tw T* (\023\030\024\f\021\030\026\027\036\027\027\t\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\016\021\036\035\034\027\024\f\021\017 \024\027\022\024\035\024\020\ \017\004\036\f\022\017\b )Tj 0.428 Tw T* [(\024\021\007\036\035\036\027\017\005 \026\002\007\024\n\017\027\026\035\034\ \027\024\005 )0.5(\b\017\030\031\030\020\017\017 \017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\005 )Tj 0.556 Tw T* [(\026\002\007\024\n\017\027\026\035\034\027\024\005 )0.6(\b\017\030\031\030\020\017\017, )0.5(\024\022\026\t\r\026\033\013\017\b )0.6(\220\022\f\021\030\036\027)]TJ 0 Tw (-)Tj 0.14 Tw T* (\027\031\033 \023\024\n\024\013\034. \210\f\024\002\t\036 \f\035\024\032\ \027\024\f\021\017 \r\024\027\017\022\026\033\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.258 Tw T* [(\024\002\b\024\007\017\n\024\f\021\017 )0.6(\023\030\024\r\036\007\036\027\017\016 )0.5(\024\002\001\017\030\027\t\b )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b )]TJ 0.379 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r. \217\026\022 \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \n\024\032\027\024 \002\036)Tj 0 Tw (-)Tj 0.159 Tw T* (\024\023\026\f\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024 \035\036\004\017\021\034 \b\017\030\ \031\030\020\017\004\036\f\022\017\n \023\031\021\036\n. )Tj 0.175 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\024\f\035\036\007\027\017\b \007\r\031\ \b \f\021\024\035\036\021\017\005 \001\035\017 \024\002\001\017\030\027\t\ \036 )Tj T* (\007\036\002\026\021\t \024)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\036\n \n\036\021\024\007\036 \030\036\036\022\006\017\017\ \030\026\022\026 \024\002\024\007\024\004\027\024\005 )Tj 0.159 Tw 23.244 64.543 Td (\022\017\001\022\017. \210\027\017 \022\026\f\026\035\017\f\034 \024\f\027\ \024\r\027\024\005 \023\030\024\002\035\036\n\t \r\t\f\024\022\024\020\024\ )Tj 0.068 Tw T* (\035\017\020\017\030\024\r\026\027\017\016 \035\017\n\235\024-\f\024\f\031\ \007\017\f\021\024\005 \027\024\032\022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017\035\017 \023\024\f\035\036 )Tj -0.033 Tw T* (\n\026\027\017\023\031\035\016\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\b\024\035\034\033, \001\017\030\024\022\017\b \017\035\017 \ \024\020\030\026\027\017\004\036\027\027\t\b )Tj 0.137 Tw T* [(\017\f\f\036\004\036\027\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.6 0 Td [(\017\027\021\036\030\036\f\026 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 4.945 0 Td [(\021\036\b\027\017\022\036 )0.5(\017\024\035\016\006\017\017 )0.6(\002\036 )0.5(\023\030\017)]TJ 0 Tw (-)Tj -0.013 Tw -10.545 -1.218 Td (\022\024\f\027\024\r\036\027\017\016 $\021.\036. \030\026\027\027\016\016\ \017\024\035\016\006\017\016 \035\017\n\235\024-\f\024\f\031\007\017\f\ \021\024\005 )Tj 0.183 Tw T* (\027\024\032\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\n\017 \n\026\027\017\023\031\035\016\006\ \017\016\n\017$. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\n, )Tj 0.328 Tw 0 -1.218 TD (\021\017\023 \022\024\035\220\022\021\024\n\017\017 \024\f\027\024\r\026\ \027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\017 \024\023\031\b\024\035\017 )Tj -0.017 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\031\007\017\f\021\024\n \035\017\n\235\024\007\030\036\027\026\032\ \036. \216\024\021\016 \220\021\024 \024\f\021\026\036\021\f\016 \f\023\024\ \030)Tj 0 Tw (-)Tj 0.029 Tw T* (\027\t\n, \r\t\f\024\022\026\016 \023\036\030\036\r\016\022\026 \035\017\ \n\235\026\021\017\004\036\f\022\024\005 \027\024\032\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.1 Tw T* (\021\024\007\017\022\026 \002\036 \023\030\017\022\024\f\027\024\r\036\027\ \017\016, \022\026\032\036\021\f\016, \027\036 \007\026\033\021 \007\024\ \023\024\035)Tj 0 Tw (-)Tj 0.165 Tw T* (\027\017\021\036\035\034\027\024\020\024 \023\030\036\017\n\031\013\036\f\ \021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\004\036\f\022\024\n \023\035\026\027\036\ ; )Tj -0.027 Tw T* (\021\036\n \027\036 \n\036\027\036\036, \023\024\f\035\036\007\027\017\036\ \007\026\027\027\t\036 \023\024\007\021\r\036\030\032\007\026\033\021 \023\ \030\017\027)Tj 0 Tw (-)Tj 0.27 Tw 0 -1.218 TD (\006\017\023 \023\024\035\027\024\020\024 \n\036\024\022\024\035\017\004\ \036\f\022\024\020\024 \031\007\026\035\036\027\017\016 $CME$ \022\026\ \022 )Tj 0.073 Tw 0 -1.218 TD (\024\023\021\017\n\026\035\034\027\t\005 \023\024\007\b\024\007, \022\024\ \021\024\030\t\005 \f\035\036\007\031\036\021 \023\030\017\n\036\027\016\ \021\034 \022\024 )Tj -0.008 Tw 0 -1.218 TD (\r\f\036\n \r\017\007\026\n \030\026\022\026 \021\024\035\f\021\024\005 \ \022\017\001\022\017. CME \r\022\035\033\004\026\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 )Tj 0.343 Tw T* [(\021\030\017 \024\f\027\024\r\027\t\b \022\024\n\023\024\027\036\027\021\ \026: )0.5(\r\024-\023\036\030\r\t\b, \030\026\f\f\036\004\036\027\017\036 )]TJ 0.023 Tw T* (\n\036\032\007\031 \002\030\t\032\036\036\004\027\024\005 \023\035\024\f\ \022\024\f\021\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\017\036\021\026\035\034\027\024\005 \235\026\f)Tj 0 Tw (-)Tj 0.076 Tw T* (\006\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\036 \002\030\t\032\036\005\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\005 \024\002\024\035\024\004\022\036 \002\030\t)Tj 0 Tw (-)Tj 0.091 Tw T* [(\032\036\036\004\027\024\005 )0.6(\235\026\f\006\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.189 0 Td [(\r\017\f\006\036\030\026\035\034\027\024\005 )0.5(\002\030\033\001\017\027\t, )0.5(\022\024\021\024\030\026\016 )]TJ 0.377 Tw -8.189 -1.218 Td (\f\024\007\036\030\032\017\021 \r\f\036 \035\017\n\235\026\021\017\004\036\ \f\022\017\036 \031\035\t, \007\030\036\027\017\030\031\033\013\017\036\ )Tj 0.515 Tw T* (\024\002\035\026\f\021\034 \024\023\031\b\024\035\017. \200\021\024\030\t\ \n \022\024\n\023\024\027\036\027\021\024\n \016\r\035\016\036\021\f\016\ )Tj 0.249 Tw T* [(\006\036\027\021\030\026\035\034\027\026\016 \f\024\f\031\007\017\f\021\026\ \016 )0.5(\023\036\030\036\r\016\022\026, \022\024\021\024\030\026\016 \023\024\021\ \036\027)]TJ 0 Tw (-)Tj 0.047 Tw T* (\006\017\026\035\034\027\024 \031\f\021\030\026\027\016\036\021 \n\036\021\ \026\f\021\026\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017\004\036\f\022\017\036 \031\035\t, )Tj 0.079 Tw T* (\f\024\f\031\007\017\f\021\031\033 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\r\027\031\033 \017\027\r\026\017\033 \r\024 \r\f\036\005 \024\ \002\035\026\f\021\017 \030\036)Tj 0 Tw (-)Tj 0.175 Tw T* (\020\017\024\027\026\030\027\024\020\024 \007\030\036\027\017\030\024\r\026\ \027\017\016. \003\026\021\036\n \021\030\036\021\017\005 \022\024\n\023\ \024\027\036\027\021 )Tj -0.016 Tw T* (\023\030\036\007\f\021\026\r\035\036\027 \030\036\036\022\006\017\036\005\ \007\024\f\021\026\021\024\004\027\024\005 \007\035\017\027\t \022\017\001\ \036\004\027\017)Tj 0 Tw (-)Tj 0.153 Tw T* (\022\026 \007\035\016 \031\007\026\035\036\027\017\016 \r\f\036\b \r\024\ \r\035\036\004\036\027\027\t\b \023\036\030\017\022\024\035\017\004\036\f\ \022\017\b )Tj 0.245 Tw T* [(\035\017\n\235\026\021\017\004\036\f\022\017\b )0.5(\031\035\024\r )0.5([41]. \210\002\013\017\036 \017\f\b\024\007\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 )Tj 0.099 Tw T* (\030\036\027\017\016 \035\036\021\026\035\034\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\ \024\032\027\036)Tj 0 Tw (-)Tj 0.201 Tw T* (\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\001\017\b\ \030\026\035\017\004\027\t\036 \023\035\026\027\024\r\t\036 )Tj 0.237 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\036 \024\023\036\030\026\006\ \017\017, \r\022\035\033\004\026\016 \030\036\036\022\006\017\033 \035\036\ \r\024\005 )Tj 0.092 Tw T* [(\023\024\035\024\r\017\027\t )0.6(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, )0.6(\f\024\023\024\f\021\026\r\017\n\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.864 0 Td (\021\026\022\024\r\t)Tj 0 Tw (-)Tj 0.172 Tw -18.864 -1.218 Td (\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \n\024\035\024\007\t\b \022\024\020\024\030\021\026\ \b [2]. \210\007\027\026\022\024 \220\022\f\021\030\036\027)Tj 0 Tw (-)Tj 0.193 Tw T* (\027\026\016 \024\023\036\030\026\006\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \024\f\035\024\032\027\036\027\027\024\020\024 \030\ \026\022\026 \035\036\r\024\005 )Tj 0.088 Tw T* [(\023\024\035\024\r\017\027\t )0.5(\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\032\017\035\024\n )Tj 0.092 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\n \r\024\030\026\f\021\036 \f\024\023\030\ \016\032\036\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\024\n \023\030\024\002\035\036\n. )Tj 0.25 Tw T* [(\203\026\035\017\004\017\036 )0.5(\n\027\024\032\036\f\021\r\036\027\027\t\b )0.6(\b\030\024\027\017\004\036\f\022\017\b )0.6(\026\002\024\035\036\r\026\027\017\005 )]TJ 0.033 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\024\032\017\035\024\020\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026 \n\024\ \032\036\021 )Tj 0.205 Tw T* (\023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\f\017\021\034 \004\026\f\021\024\021\031 \024\f)Tj 0 Tw (-)Tj 0.147 Tw T* [(\035\024\032\027\036\027\017\005 )0.5(\035\036\004\036\027\017\016 )0.5([3,10,25]. \200)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\024\033 )0.5(\024\004\036\030\036\007\034, \035\036\004\036)]TJ 0 Tw (-)Tj 0.052 Tw T* (\027\017\036 \035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\r\ \024\024\002\030\026\024\r\026\027\017\005 \021\026\022\032\036 \n\024\032\ \036\021 )Tj 0.057 Tw T* (\031\b\031\007\001\017\021\034 \021\036\004\036\027\017\036 \f\024\023\031\ \021\f\021\r\031\033\013\017\b \b\030\024\027\017\004\036\f\022\017\b \026\ \002\024)Tj 0 Tw (-)Tj T* (\035\036\r\026\027\017\005 \017\035\017 \r\t\r\026\021\034 \017\b \024\002\ \024\f\021\030\036\027\017\016.)Tj /T1_2 1 Tf 0.025 Tw 0 -2.436 TD (\203\004\220\003\002\006\013 \006\t\217\220\004, \f\t\235\211\223\t\r \b\ \004)Tj /Span<>> BDC ( )Tj EMC (\006\004\213\t\003\t\r \212\002\217\f\r\002\212\r)Tj 0 Tw (-)Tj 0.375 Tw 0 -1.218 TD (\006\004\204\t\002\b\b\013\216 \002\217\f\002\202\b\r\b\t\005 \210)Tj /Span<>> BDC ( )Tj EMC (\212\004\204\t\r\b\003\002 \212\002\202\t\f\002\n\002 )Tj 0 Tw T* (\t)Tj /Span<>> BDC ( )Tj EMC (\217\003\004\006\201\r\217\220\002\n\002 \002\213\006\004\217\003\004)Tj /T1_0 1 Tf 0.002 Tc 0.24 Tw T* (\215\026\006\017\036\027\021\t \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026 \023\035\ \024\b\024)2( )]TJ 0.47 Tw T* [(\023\036\030\036\027\024\f\016\021 )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\036 )0.5(\024\f\035\024\032\027\036\027\017\016 )0.5(\017-\026)2( )]TJ 0.075 Tw T* (\n\036\027\034\001\017\b \235\017\017\024\035\024\020\017\004\036\f\022\ \017\b \030\036\036\030\r\024\r [35]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.041 Tw T* (\030\t\b \017\f\f\035\036\007\024\r\026\027\017\016\b [42\22649] \023\030\ \024\r\024\007\017\021\f\016 \026\027\026\035\017 \235\026\022)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.006 Tw T* (\021\024\030\024\r, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \023\024\030\026\032\036\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.091 Tw T* [(\027\024\005 \f\017\f\021\036\n\t \024\030\020\026\027\024\r, \004\021\024\ \002\t \024\023\030\036\007\036\035\017\021\034 \017\b \r\035\017\016\027\ \017\036)2( )]TJ 0.213 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.425 0 Td [(\035\036\021\026\035\034\027\024\f\021\034 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\023\024\032\017\035\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 15.678 0 Td [(\f\021\026\030\004\036\f\022\024\020\024)2( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.8528 56.0378 Tm (140)Tj ET endstream endobj 100 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 341.3784 42.7216 Tm [(Sur)31(gical appr)20(oach for acute colon tumor obstr)10(uction )]TJ 2.798 -1 Td [(in elderly and octogenarian patients $r)31.1(e)11(vie)11(w$)]TJ -42.646 1 Td [(\224\b\017\220\017\020\b\213\f\205\007\005 \026)11(\005\007)-10(\026\b\007\005 \223\017\b\022\025\205)-10(\026\017\025\255 \025\210\026)-19.9(\220\017\005\216\b\025\t\t\025\255 )]TJ 0 -1 TD [(\t\f\223\017\025\002\025\217\b\024\025\205)-10(\026\b \025\223\220)21(\002\025\013\f\016\025\020)10(\025 \020)10(\f\t\f\001\005 \220\022\210\025\013\n\t\240\002 \223\025\235\b\013\025\020\ )10(\025 )]TJ T* [(\b\022\205)-10(\026)11(\005\017\213\f\205\007)10(\025\020)10(\025 \016\025)21(\001\017\005\205)-10(\026)11(\005 $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.23 Tw 10 0 0 10 42.5197 724.8299 Tm (\031\210\216\224\003\004\212\b\013\r \212\002\240\216\002\240\013 \217)Tj /Span<>> BDC ( )Tj EMC (\t\217\212\002\f\001\213\002\004\b\t\r\214 \253\214\002\217\003\004 )Tj 0 Tw 0 -1.218 TD (\220)Tj /Span<>> BDC ( )Tj EMC (\216\t\006\210\006\n\t\t\273 \b\004)Tj /Span<>> BDC ( )Tj EMC (\212\r\006\002\214 \224\003\004\212\r)Tj /T1_2 1 Tf 0.262 Tw T* (\230\f\b\024\007\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036\023\036\030\036\004\017\f\035\036\027\027\024\020\024, \023\ \030\036\007\f\021\026\r\035\016\033\021 \017\027)Tj 0 Tw (-)Tj 0.25 Tw T* (\021\036\030\036\f \n\036\021\024\007\t \r\030\036\n\036\027\027\024\005\ \007\036\022\024\n\023\030\036\f\f\017\017 \024\002\024\007\024\004\027\ \024\005 )Tj 0.19 Tw T* (\022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \024\021\f\030\024\004\036\027\ \027\024\005 \024\023\036\030\026\006\017\036\005, \004\021\024 )Tj 0.638 Tw T* (\023\030\036\007\023\024\035\026\020\026\036\021 \027\026\004\017\021\036\ \035\034\027\024 \f\027\017\017\021\034 \030\017\f\022 \023\024\f\035\036\ )Tj 0 Tw (-)Tj 0.234 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.228 Tw 0 -1.218 TD [(\031\035\031\004\001\017\021\034 )0.6(\f\024\006\017\026\035\034\027\024-\021\030\031\007\024\r\031\033 )0.5(\030\036\026\002\017\035\017\021\026\006\017\033 )0.5(\002\024\035\034)]TJ 0 Tw (-)Tj 0.06 Tw T* (\027\t\b. \200)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\b \017\f\f\035\036\007\024\r\026\027\017\ \016\b \002\t\035\017 \023\030\036\007\035\024\032\036\027\t )Tj 0.067 Tw T* (\007\r\031\b\220\021\026\023\027\t\036 \023\024\007\b\024\007\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\024\005 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\005 )Tj 0.219 Tw T* (\007\036\022\024\n\023\030\036\f\f\017\036\005 \022\017\001\036\004\027\017\ \022\026, \035\017\002\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.119 Tw T* (\f\026\n\024\030\026\f\001\017\030\016\033\013\017\b\f\016 \n\036\021\026\ \035\035\017\004\036\f\022\017\b \f\021\036\027\021\024\r $SEMS$, )Tj 0.03 Tw 0 -1.218 TD [(\035\017\002\024 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.961 0 Td [(\023\024\n\024\013\034\033 )0.5(\031\f\021\026\027\024\r\022\017 )0.6(\007\036\022\024\n\023\030\036\f\f\017\030\031\033\013\036\005 )0.6(\f\021\024)]TJ 0 Tw (-)Tj 0.136 Tw -2.961 -1.218 Td (\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \253\n\024\f\021\026 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\017\273. \237\021\024\021 \023\024\007\b\024\007\ \027\026)Tj 0 Tw (-)Tj 0.137 Tw 0 -1.218 TD (\023\030\026\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\030\026\027\036\027\017\036 \021\024\035\f\021\024\022\017\001\ \036\004\027\024\005 \024\002\f\021\030\031\022\006\017\017 )Tj 0.318 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\035\016\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n \r\t\023\024\035\027\017\021\034\ \023\035\026\027\024\r\031\033 )Tj 0.166 Tw T* (\020\036\n\017\022\024\035\220\022\021\024\n\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\004\036\f\022\017\n\017 )Tj 0.102 Tw T* (\023\030\017\027\006\017\023\026\n\017 \023\024\f\035\036 \f\021\026\002\ \017\035\017\026\006\017\017 \f\024\f\021\024\016\027\017\016 \023\026\006\ \017\036\027)Tj 0 Tw (-)Tj 0.001 Tw T* (\021\026. \215\024\007\b\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \007\036\022\024\n\023\030\ \036\f\f\017\024\027\027\024\005 \f\021\024)Tj 0 Tw (-)Tj 0.119 Tw T* (\n\t \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\n \220\021\026\023\036 \f\004\017\021\026\036\021\f\016\ )0.5(\024\f\031\013\036\f\021\r\017\n\024\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\002\036)Tj 0 Tw (-)Tj -0.035 Tw T* (\024\023\026\f\027\024\005 \026\035\034\021\036\030\027\026\021\017\r\024\ \005 \220\022\f\021\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.194 Tw T* (\f\027\017\032\036\027\017\016 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 [32,33]. )Tj 0.197 Tw T* [(\204\027\024\020\017\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.562 0 Td [(\024\f\027\024\r\027\024\n )0.5(\002\t\035\017 )0.6(\f\024\f\030\036\007\024\021\024)]TJ 0 Tw (-)Tj 0.282 Tw -10.562 -1.218 Td (\004\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 SEMS \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\027\027\024\005 \030\036\036\022\006\017\036\005\ )Tj 0.064 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.817 0 Td [(\024\002\f\021\030\031\022\021\017\r\027\024\n )0.6(\030\026\022\036 )0.5(\035\036\r\024\005 )0.5(\023\024\035\024\r\017\027\t )0.6(\024\002\024\007\024\004\027\024\005 )]TJ 0.601 Tw -1.817 -1.218 Td (\022\017\001\022\017. \203\036\007\026\r\027\017\005 \030\036\023\030\036\ \036\027\021\026\021\017\r\027\t\005 \n\036\021\026\026\027\026\035\017\ , )Tj 0.361 Tw T* [(\023\030\024\r\036\007\036\027\027\t\005 Jain e)-12(t al., \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035, \004\ \021\024 )]TJ 0.158 Tw T* (SEMS \017\n\036\036\021 \027\036\f\022\024\035\034\022\024 \023\030\036\017\ \n\031\013\036\f\021\r \023\036\030\036\007 \220\022\f\021\030\036\027)Tj 0 Tw (-)Tj 0.186 Tw T* [(\027\024\005 )0.5(\030\036\036\022\006\017\036\005, )0.6(\r\022\035\033\004\026\016 )0.5(\027\026\004\017\021\036\035\034\027\024 )0.5(\002\024\035\036\036 )0.5(\027\017\022\017\036 )]TJ 0.137 Tw T* [(\023\024\022\026\026\021\036\035\017 )0.5(\023\024\f\021\024\016\027\027\t\b )0.6(\f\021\024\n, )0.5(\f\027\017\032\036\027\017\036 )0.6(\004\026\f\021\024\021\t )0.5(\027\036)]TJ 0 Tw (-)Tj -0.04 Tw T* (\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 \026\027\026\f\021\ \024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\005 \r\027\031\021\030\017\002\024\035\034\027\017\004)Tj 0 Tw (-)Tj 0.133 Tw T* (\027\024\005 \035\036\021\026\035\034\027\024\f\021\017 [32]. \225\021\024\ \017\021 \024\021\n\036\021\017\021\034, \004\021\024 \023\030\017\n\036\ \027\036)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\017\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \f\023\ \024\f\024\002\024\r \007\036\022\024\n\023\030\036\f\f\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n )Tj 0.188 Tw T* (\004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \f\021\036\027\ \021\017\030\024\r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0.424 Tw T* (\035\036\r\024\005 \023\024\035\024\r\017\027\t \024\002\024\007\024\004\ \027\024\005 \022\017\001\022\017, \024\f\035\024\032\027\036\027\027\024\ \n )Tj 0.033 Tw T* (\024\f\021\030\024\005 \024\002\021\031\030\026\006\017\024\027\027\024\005\ \027\036\023\030\024\b\024\007\017\n\024\f\021\034\033 \021\036\b\027\017\ \004\036\f\022\017 )Tj 0.26 Tw T* (\f\035\024\032\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\030\024\r\024\032\007\026\036\021\f\016 \b\024\030\024\001\017\ \n\017 \030\036\031\035\034\021\026\021\026\n\017 )Tj 0.217 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (78% \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\ \t\b \006\036\027\021\030\026\b [34]. )Tj 0.27 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \035\036\004\036\002\027\t\b \031\ \004\030\036\032\007\036\027\017\005, \022\031\007\026 \023\024\f\021\031\ )Tj 0 Tw (-)Tj 0.084 Tw T* (\023\026\033\021 \002\024\035\034\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\n \024\002\f\021\030\031\022\021\017\r\027\t\n \030\026\ \022\024\n \035\036\r\024\005 )Tj 0.147 Tw T* [(\023\024\035\024\r\017\027\t )0.6(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, )0.6(\021\026\022\024\020\024 )0.5(\r\t\f\024\022\024\020\024 )0.6(\031\030\024\r)]TJ 0 Tw (-)Tj 0.094 Tw T* [(\027\016 )0.5(\022\r\026\035\017\235\017\022\026\006\017\017 )0.6(\220\027\007\024\f\022\024\023\017\f\021\024\r )0.6(\027\036\021. )0.5(\215\024\n\017\n\024 )0.5(\220\021\024\020\024, )]TJ 0.411 Tw T* (\n\017\022\030\024\023\036\030\235\024\030\026\006\017\017, \r\024\027\017\ \022\026\033\013\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 )Tj 0.055 Tw T* (\007\026\027\027\024\005 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 \024\023\006\017\017, \n\024\020\031\021 \024\022\026\t\r\026\021\ \034 \024\021)Tj 0 Tw (-)Tj T* [(\030\017\006\026\021\036\035\034\027\024\036 \r\035\017\016\027\017\036 \ )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \024\027\022\024\035\024\020\017\004\ \036\f\022\017\036 )Tj 0.208 Tw T* (\030\036\031\035\034\021\026\021\t. \225\024\r\036\030\001\036\027\027\024\ \017\027\026\004\036, \f\022\035\026\007\t\r\026\036\021\f\016 \f\017\021\ \031)Tj 0 Tw (-)Tj 0.117 Tw T* (\026\006\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \023\024\007\b\024\007\026\ \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n )Tj 0.234 Tw T* (\007\036\022\024\n\023\030\036\f\f\017\024\027\027\024\005 \f\021\024\n\t\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \220\021\026\023\036, \007\026\027\027\024\036 )Tj 0.318 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\024, \023\030\036\007\f\021\026\r\035\016\036\021 \f\024\ \002\024\005 )Tj 0.266 Tw T* [(\021\036\b\027\017\004\036\f\022\017 )0.6(\002\024\035\036\036 )0.5(\023\030\024\f\021\031\033 )0.6(\024\023\006\017\033, )0.5(\022\024\021\024\030\031\033 )0.6(\n\024\032\027\024 )]TJ 0.016 Tw T* (\r\t\023\024\035\027\016\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \n\017\027\017\017\027\r\026\017\ \r\027\t\b \021\036\b\027\024\035\024)Tj 0 Tw (-)Tj T* (\020\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\027\027\t\b \f\017\021\031\026\006\017\016\b [35]\ .)Tj 0.37 Tw T* (\200 \023\024\f\035\036\007\027\017\036 \020\024\007\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\035\031\004\001\036\005 \f\021\024\030\024\027\t \026\030\036\ \022\024)Tj 0 Tw (-)Tj 0.505 Tw T* (\n\036\027\007\024\r\026\035\017 \f\036\002\016 \035\026\023\026\030\024\ \f\022\024\023\017\004\036\f\022\017\036 \024\023\036\030\026\021\017\r\027\ \t\036 )Tj 0.317 Tw 23.244 64.543 Td [(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\022\036 )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, \r)]TJ /Span<>> BDC ( )Tj EMC 20.659 0 Td (\021\024\n )Tj -0.021 Tw -20.659 -1.218 Td (\004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \024\f\035\024\032\027\201\027\027\024\n \021\036\004\036\027\ \017\017 \026\002\024\035\036\r\026\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\b\017)Tj 0 Tw (-)Tj 0.021 Tw T* (\030\031\030\020\017\004\036\f\022\017\b \f\021\026\006\017\024\027\026\030\ \026\b, \024\022\026\t\r\026\033\013\017\b \027\036\024\021\035\024\032\ \027\031\033 )Tj 0.161 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\031\033 \023\024\n\024\013\034.\ \224\026\022\017\n \024\002\030\026\024\n, \030\026\030\026\002\024\021\ \022\026 )Tj 0.066 Tw T* (\035\036\004\036\002\027\024-\007\017\026\020\027\024\f\021\017\004\036\f\ \022\024\005 \021\026\022\021\017\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj -0.038 Tw T* [(\n\017\027\017\017\027\r\026\017\r\027\024\005 )0.5(\007\036\022\024\n\023\030\036\f\f\017\017 \024\002\024\007\024\004\027\024\ \005 )0.5(\022\017\001\022\017 \016\r)]TJ 0 Tw (-)Tj -0.077 Tw 0 -1.218 TD (\035\016\036\021\f\016 \r\036\f\034\n\026 \026\022\021\031\026\035\034\027\ \024\005 \026\007\026\004\036\005 \b\017\030\031\030\020\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\027\024\n )Tj 0.093 Tw 0 -1.218 TD (\035\036\004\036\027\017\017 \024\002\021\031\030\026\006\017\024\027\027\ \024\005 \027\036\023\030\024\b\024\007\017\n\024\f\021\017 \024\002\024\ \007\024\004\027\024\005 )Tj 0.039 Tw T* (\022\017\001\022\017. \215\030\024\f\021\026\016 \022\024\035\024\f\021\024\ \n\026 \016\r\035\016\036\021\f\016 \004\026\f\021\034\033 \220\021\026\023\ \027\024\020\024 )Tj 0.149 Tw T* [(\035\036\004\036\027\017\016 )0.6(\035\036\r\024\f\021\024\030\024\027\027\036\005 )0.5(\027\036\023\030\024\b\024\007\017\n\024\f\021\017 )0.6(\024\002\024\007\024\004\027\024\005 )]TJ 0.127 Tw T* (\022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \023\036\030\r\024\020\024 \220\021\026\023\026 \022\017\001\ \036\004\027\031\033 \027\036\023\030\024\b\024\007\017)Tj 0 Tw (-)Tj 0.058 Tw T* [(\n\024\f\021\034 )0.5(\031\f\021\030\026\027\016\033\021 \f)]TJ /Span<>> BDC ( )Tj EMC 7.902 0 Td [(\023\024\n\024\013\034\033 )0.5(\022\024\035\024\f\021\024\n\t. \225\030\036\007\017 )0.5(\022\024\035\024)]TJ 0 Tw (-)Tj -0.01 Tw -7.902 -1.218 Td (\f\021\024\n \027\026\017\002\024\035\036\036 \004\026\f\021\024 \235\024\ \030\n\017\030\031\036\n\t\n\017 \016\r\035\016\033\021\f\016 \021\030\026\ \027\f)Tj 0 Tw (-)Tj 0.281 Tw 0 -1.218 TD (\r\036\030\024\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\f\021\024\n\t. \215\030\036\017\n\031\013\036\f\021\r\024\ \027\026\035\017\004\017\016 )Tj 0.083 Tw 0 -1.218 TD (\022\024\035\024\f\021\024\n\t \026\022\035\033\004\026\036\021\f\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \024\027\026 \024\002\036\f\023\036\004\017\r\026\ \036\021 )Tj 0.109 Tw T* (\007\036\022\024\n\023\030\036\f\f\017\033 \021\024\035\f\021\024\005 \022\ \017\001\022\017, \n\017\027\017\n\017\017\030\031\036\021 \b\017\030\031\ \030)Tj 0 Tw (-)Tj 0.05 Tw T* (\020\017\004\036\f\022\031\033 \021\030\026\r\n\031, \f\027\017\032\026\036\ \021 \030\017\f\022 \022\024\027\021\026\n\017\027\026\006\017\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.195 Tw T* [(\023\024\007\020\024\021\024\r\035\036\027\027\024\020\024 )0.5(\022\017\001\036\004\027\017\022\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\r\024\035\016\036\021 \023\024\f\021\026\r\017\021\034 )Tj 0.189 Tw T* (\f\021\026\007\017\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\027\004\026\021\036\035\034\027\024\005 \030\036\036\022\006\ \017\017 [18,26]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036)Tj 0 Tw (-)Tj 0.025 Tw T* (\020\024\007\027\016\001\027\017\005 \007\036\027\034 \021\024\035\034\022\ \024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \030\026\027\007\024\n\017\017\030\024\r\026\027\027\ \024\n )Tj 0.308 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017 \f\030\026\r\027\017\r\026\036\ \021\f\016 \017\f\023\024\035\034\024\r\026\027\017\036 \007\036\022\024\ \n)Tj 0 Tw (-)Tj 0.187 Tw T* (\023\030\036\f\f\017\024\027\027\024\005 \f\021\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \253\n\024\f\021\026 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\017\273 )Tj 0.186 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\027\027\024\005 \030\036\036\022\006\017\036\005\ . \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\017\016 )Tj 0.142 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016, \r\022\035\033\004\026\016 \027\ \036\002\024\035\034\001\031\033 \022\024\020\024\030\021\031 \023\026\006\ \017\036\027)Tj 0 Tw (-)Tj 0.053 Tw T* (\021\024\r $)Tj /T1_3 1 Tf 0 Tw (n)Tj /T1_2 1 Tf 0.053 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (121$, \007\035\017\021\036\035\034\027\t\005 \023\036\030\017\024\007 \r\ \022\035\033\004\036\027\017\016 $1978\226)Tj 0.179 Tw T* (1993$ \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036 \023\030\017\n\036\027\036\027\017\016\ \035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\b )Tj 0.058 Tw T* [(\021\036\b\027\024\035\024\020\017\005, )0.6(Kr)-32(onbor)-32(g )0.5(e)-12(t )0.5(al. )0.5(\027\026\002\035\033\007\026\035\017 )0.5(\027\026\004\017\021\036\035\034\027\024\036 )]TJ -0.027 Tw T* (\f\027\017\032\036\027\017\036 \004\026\f\021\024\021\t \023\024\f\021\024\ \016\027\027\t\b \022\024\035\024\f\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\027\007\036\027\006\017\033 )Tj 0.122 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\030\036\007\ \017 )Tj -0.011 Tw T* (\023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\001\017\b\ \007\r\031\b\220\021\026\023\027\t\005 \023\024\007\b\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\007\036\022\024\n)Tj 0 Tw (-)Tj 0.067 Tw T* (\023\030\036\f\f\017\024\027\027\024\005 \f\021\024\n\024\005 [4]. \204\036\ \021\026\026\027\026\035\017 2015 \020\024\007\026 \f\031\n)Tj 0 Tw (-)Tj 0.21 Tw T* (\n\017\030\031\036\021 \030\036\031\035\034\021\026\021\t \r\024\f\034\n\ \017 \f\030\026\r\027\017\021\036\035\034\027\t\b \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj 0.061 Tw T* (\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\026\f\021\017\036\n 2424 \023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (1977 \023\024)Tj /Span<>> BDC ( )Tj EMC (2015)Tj /Span<>> BDC ( )Tj EMC (\020\020. )Tj 0.122 Tw T* (\216\024\021\016 \n\036\021\026\026\027\026\035\017 \027\036 \r\t\016\r\ \017\035 \f\031\013\036\f\021\r\036\027\027\t\b \030\026\035\017\004\017\ \005 )Tj -0.046 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (30-\007\027\036\r\027\024\005 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\024\005 \035\036\021\026\035\034\027\024\f\021\017 \n\036\ \032\007\031 )Tj 0.191 Tw T* (\020\030\031\023\023\026\n\017, \r\022\035\033\004\036\027\027\t\n\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.142 Tw T* (\021\024\r, \022\024\021\024\030\t\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \220\022\f\021\030\036\027\027\024\n \220\021\026\023\ \036 \002\t\035\026 \027\026)Tj 0 Tw (-)Tj 0.232 Tw T* [(\035\024\032\036\027\026 )0.5(\007\036\022\024\n\023\030\036\f\f\017\024\027\027\026\016 )0.6(\f\021\024\n\026, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 15.744 0 Td [(\r\021\024\030\t\n )0.5(\220\021\026\023\024\n )]TJ 0.164 Tw -15.744 -1.218 Td [(\r\t\023\024\035\027\016\035\024\f\034 )0.6(\030\026\007\017\022\026\035\034\027\024\036 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\024, )0.6(\026\235\017\022\f\017)]TJ 0 Tw (-)Tj 0.159 Tw T* (\030\024\r\026\027\026 \002\024\035\034\001\026\016 \004\026\f\021\024\021\ \026 \235\024\030\n\017\030\024\r\026\027\017\016 \023\036\030\r\017\004\ \027\024\020\024 )Tj 0.16 Tw T* (\026\027\026\f\021\024\n\024\026, \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\036 \022\024\035\017\004\036\f\021\r\024 \023\026\ \006\017\036\027\021\024\r \024\f\021\026)Tj 0 Tw (-)Tj 0.018 Tw T* (\035\017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\024\016\027\027\024\005 \f\021\024\n\024\005 [36]. \203\036\ \007\026\r\027\036\036 \030\036\021\030\024\f\023\036\022)Tj 0 Tw (-)Tj 0.253 Tw T* [(\021\017\r\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \r\t\023\ \024\035\027\036\027\027\024\036 V)30.1(eld JV, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al., )Tj 0.032 Tw T* [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\024, )0.6(\004\021\024 )0.5(\017\f\023\024\035\034\024\r\026\027\017\036 )0.6(\007\036\022\024\n\023\030\036\f)]TJ 0 Tw (-)Tj 0.041 Tw T* (\f\017\024\027\027\024\005 \f\021\024\n\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \220\022\f\021\030\036\027\027\024\n \220\021\026\023\ \036 \023\030\017\r\036\035\024 )Tj 0.093 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC [(\027\026\004\017\021\036\035\034\027\024\n\031 \f\027\017\032\036\027\017\ \033 )0.5(90-\007\027\036\r\027\024\005 \035\036\021\026\035\034\027\024\f\021\017\ )]TJ 0.247 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\027\027\024\005 \030\036\036\022\006\017\036\005\ $1,7% \023\030\024)Tj 0 Tw (-)Tj 0.212 Tw T* (\021\017\r 7,2%, )Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.212 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006$. \237\021\024 \030\026\035\017\004\017\036 \002\t\035\024 \024\f\ \024\002\036\027\027\024 )Tj 0.156 Tw T* (\r\t\030\026\032\036\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f\021\026\030\001\036 70 \035\036\021\ $3,5% \023\030\024\021\017\r )Tj 0 Tw T* (13,7%, )Tj /T1_3 1 Tf 3.062 0 Td (p)Tj /T1_2 1 Tf 0.2 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,027$. \025\030\024\n\036 \021\024\020\024, \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b, \022\024\021\024\030\t\n )Tj 0.146 Tw -3.062 -1.218 Td (\002\t\035\026 \f\235\024\030\n\017\030\024\r\026\027\026 \007\036\022\024\ \n\023\030\036\f\f\017\024\027\027\026\016 \f\021\024\n\026, \004\026\013\ \036 )Tj 0.39 Tw T* (\r\t\023\024\035\027\016\035\017\f\034 \035\026\023\026\030\024\f\022\024\ \023\017\004\036\f\022\017\036 \030\036\036\022\006\017\017 $56,8% )Tj 0.102 Tw T* (\023\030\024\021\017\r 9,2%, )Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.102 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$, \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\013\036 \027\026\022\035\026\007\t\r\026\035\017\f\034 \023\036\ \030)Tj 0 Tw (-)Tj 0.058 Tw T* (\r\017\004\027\t\036 \026\027\026\f\021\024\n\024\t $88,5% \023\030\024\ \021\017\r 40,7%, )Tj /T1_3 1 Tf 0 Tw (p)Tj /T1_2 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4895 56.0378 Tm (139)Tj ET endstream endobj 97 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 432.5579 Tm (\022\017\001\022\017. \210\007\027\026\022\024 \007\024)Tj /Span<>> BDC ( )Tj EMC (\f\017\b \023\024\030 \007\017\f\022\031\021\017\030\031\033\021\f\016 \r\ \024\023\030\024\f\t \027\036 )Tj 0.132 Tw 0 -1.218 TD (\021\024\035\034\022\024 \035\036\004\036\002\027\024-\007\017\026\020\027\ \024\f\021\017\004\036\f\022\024\005 \021\026\022\021\017\022\017, \027\024\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.43 Tw T* (\201\n\026 \b\017\030\031\030\020\017\004\036\f\022\017\b \024\023\036\030\ \026\006\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\021\031\030\026\006\017\024\027\027\024\005 )Tj 0.201 Tw T* (\027\036\023\030\024\b\024\007\017\n\024\f\021\017 \024\002\024\007\024\004\ \027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017\035\024\020\024 )Tj 0.073 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026. \215\ \030\036\017\n\031\013\036\f\021\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\024\f\021\026\021\022\017 )Tj 0 Tw T* (\030\026\035\017\004\027\t\b \023\024\007\b\024\007\024\r \023\030\036\007\ \f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 1.)Tj 0.179 Tw T* (\025 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\n \n\036\021\024\ \007\026\n \007\036\022\024\n\023\030\036\f\f\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 1.131 Tw T* (\021\031\030\026\006\017\024\027\027\024\005 \027\036\023\030\024\b\024\007\ \017\n\024\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.419 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \024\021\027\024\f\016\ \021\f\016: \n\036\021\024\007 \220\027\007\024\f\022\024\023\017)Tj 0 Tw (-)Tj 0.362 Tw T* (\004\036\f\022\024\005 \220\035\036\022\021\030\024\b\017\030\031\030\020\ \017\004\036\f\022\024\005 \030\036\022\026\027\026\035\017\026\006\017\ \017 \024\023\031)Tj 0 Tw (-)Tj 0.435 Tw T* (\b\024\035\017; \n\036\021\024\007 \220\027\007\024\f\022\024\023\017\004\ \036\f\022\024\005 \017\027\021\031\002\026\006\017\017 \021\024\035\f\021\ \024\005 )Tj 0.819 Tw T* (\022\017\001\022\017; \n\036\021\024\007 \021\030\026\027\f\024\023\031\b\ \024\035\036\r\024\020\024 \f\021\036\027\021\017\030\024\r\026\027\017\016\ )Tj 0.862 Tw 23.244 13.396 Td (\f\026\n\024\030\026\f\001\017\030\016\033\013\017\n\017\f\016 \n\036\021\ \026\035\035\017\004\036\f\022\017\n\017 \f\021\036\027\021\026\n\017 )Tj 0.122 Tw T* ($SEMS$ [19,20,22]. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 )Tj 0.007 Tw T* (\024\023\031\002\035\017\022\024\r\026\027\t \030\026\002\024\021\t \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\033 \023\036\030\r\017\004\027\024\ \020\024 )Tj 0.304 Tw T* (\026\027\026\f\021\024\n\024\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\235\017\035\026\022\021\017\022\024\005 )0.5(\024\f\035\024\032\027\036\027\017\005 \023\024\f\030\036\007)]TJ 0 Tw (-)Tj -0.011 Tw T* (\f\021\r\024\n \030\026\035\017\004\027\t\b \f\023\024\f\024\002\024\r \ \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\020\024\ \023\030\024)Tj 0 Tw (-)Tj -0.047 Tw T* (\n\t\r\026\027\017\016 \024\002\024\007\024\004\027\024\005 \022\017\001\ \022\017, \r\t\023\024\035\027\036\027\017\036 \030\026\007\017\022\026\035\ \034\027\t\b )Tj 0.026 Tw T* [(\024\023\036\030\026\006\017\005 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.468 0 Td [(\235\024\027\036 )0.5(\022\017\001\036\004\027\024\005 )0.6(\027\036\023\030\024\b\024\007\017\n\024\f\021\017 )0.6(\f\024\023\030\016)]TJ 0 Tw (-)Tj 0.223 Tw -5.468 -1.218 Td (\032\036\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\005 \035\036\021\026\035\034\027\024\f\021\034\033, )Tj -0.008 Tw T* (\f\024\f\021\026\r\035\016\033\013\036\005 \024\021 8,1% \007\024)Tj /Span<>> BDC ( )Tj EMC (18,5% [15,23,24,25]. \212\030\031\020\024\005 )Tj 0.379 Tw T* (\021\026\022\021\017\004\036\f\022\017\005 \023\024\007\b\024\007 \f\r\016\ \026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036\n \007\r\031\b)Tj 0 Tw (-)Tj 0.183 Tw T* (\220\021\026\023\027\t\b \024\023\036\030\026\006\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\036\n \023\036\030\r\017\004\027\024\005 \024\ \023\031\b\024\035\017 )Tj 0.216 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\036\007\036\027\017\036\n \022\024\035\024\f\021\024\n\t \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \220\021\026\023\036 $\024\023\036\030\026)Tj 0 Tw (-)Tj 0.002 Tw T* (\006\017\017 \206\026\030\021\n\026\027\026$. \224\026\022\017\036 \002\ \024\035\034\027\t\036 \r\t\027\031\032\007\036\027\t \007\035\017\021\036\ \035\034\027\024 )Tj 0.035 Tw T* (\032\017\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \022\024\035\024\f\021\024\n\t, \004\021\024\ \027\026\004\017\021\036\035\034\027\024 \f\027\017\032\026)Tj 0 Tw (-)Tj 0.121 Tw T* (\036\021 \017\b \026\007\026\023\021\026\006\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\006\017\026\035\034\027\024\005 \f\030\036\007\036, \021\026\022 \ \022\026\022 \f\030\024\022\017 )Tj 0.03 Tw T* (\023\024\r\021\024\030\027\t\b \030\036\022\024\027\f\021\030\031\022\021\ \017\r\027\t\b \024\023\036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\033 )Tj 0.217 Tw T* (\022\024\035\024\f\021\024\n\t \f\024\f\021\026\r\035\016\033\021 \007\024\ )Tj /Span<>> BDC ( )Tj EMC (24 \n\036\f\016\006\036\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r 40\22670% )Tj 0.297 Tw T* (\f\035\031\004\026\016\b \r\024\f\f\021\026\027\024\r\017\021\036\035\034\ \027\t\005 \220\021\026\023 \024\023\036\030\026\006\017\017 \r\t\023\024\ \035)Tj 0 Tw (-)Tj -0.025 Tw T* (\027\017\021\034 \027\036\r\024\n\024\032\027\024 [21,26,27,28]. \203\026\ \022\024\027\036\006, \027\036\024\002\b\024\007\017\n\024 )Tj 0.121 Tw T* [(\031\004\017\021\t\r\026\021\034 \f\024\006\017\026\035\034\027\024-\220\ \022\024\027\024\n\017\004\036\f\022\024\036 )0.5(\026\021\030\026\021\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tw (-)Tj 0.186 Tw T* [(\004\036\027\017\036 )0.6(\030\026\022\026 )0.5(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, )0.5(\023\024\f\022\024\035\034\022\031 )0.5(\f\021\024\017\n\024\f\021\034 )]TJ 0.218 Tw T* [(\035\036\004\036\027\017\016 )0.6(\027\026\004\017\021\036\035\034\027\024 )0.6(\r\024\030\024\f\035\026 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 15.012 0 Td [(\023\024\f\035\036\007\027\017\036 )0.6(\020\024\007\t. )]TJ 0.01 Tw -15.012 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 31% \030\026\f\b\024\ \007\024\r \021\030\026\021\017\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032)Tj 0 Tw (-)Tj 0.036 Tw T* (\027\036\027\017\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \030\026\f\b\024\007\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\034\036\027\t\n\017 )Tj 0.086 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\n\017 \024\f\ \035\024\032\027\036\027\017\016\n\017 \031\r\036\035\017\004\017\r\026\033\ \021\f\016 )Tj 0.145 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (196% [29]. \225\027\017\032\036\027\017\036 \022\024\035\017\004\036\f\021\ \r\026 \023\024\f\035\036\024\023\036\030\026\006\017)Tj 0 Tw (-)Tj 0.119 Tw T* (\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 \023\024\f\035\036 \220\022\f\ \021\030\036\027\027\024\005 )Tj 0.354 Tw T* (\030\036\036\022\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\021\030\031\022\021\017\r\027\024\n \035\036\r\024\f\021\024\030\ \024\027\027\036\n \030\026\022\036 )Tj 0.049 Tw T* (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \n\024\032\036\ \021 \027\026\004\017\021\036\035\034\027\024 \f\024\022\030\026\021\017\ \021\034 \030\026\f)Tj 0 Tw (-)Tj T* (\b\024\007\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\026\r\024\024\b\030\026\027\036\027\017\036 [30,31].)Tj ET q 70.866 100.97 221.102 180.748 re W n q /GS0 gs 221.1023475 0 0 180.7709772 70.8661504 100.9469247 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\027\034\021-\024\001\016\b\037 \024\035\033\037\035\016\013\022\022\ \f\034\022\024\021\037)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Search strategy diag)14.2(ram)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \213\027\013\034\033\022\035\b\032 \027\016\n\016\020\022\030 \034\024\035\ \033\034\t \027\016\036\034\024\035\034\033\034\020\020\016\t \020\016\f\ \033\034\001\034\005\022\b\034)0.5(\024\035\022 \034\025\034\005\034\n\020\034\t \021\022\004\021\022 \034\f\ \023\001\034\027\016\036\034\013\034 \013\016\020\016\031\037)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( T)46.1(r)-2(e)-7.5(a)-9.1(t)-10.6(m)-5.3(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-9.1(c)-0.6(u)-4.8(t)-1.6(e lef)-50.9(t)32.8(-)-1.5(s)-12.5(i)-1.4(d)-5.3(e)-12.9(d c)2.8(o)-5.3(l)-1.5(o)-4(n o)-2.3(b)2(s)-14.8(t)-9.6(r)-9.1(u)-3.7(c)-32.4(t)-29.1(i)-1.3(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-1.1(u)0.7(m)-5.3(o)-3(r o)-3(r)-39(i)1.3(g)-18.7(i)3.9(n)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 167.4941 715.181 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 289.3839 715.181 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 411.2736 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 703.7117 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 167.4941 703.7117 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 289.3839 703.7117 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 411.2736 703.7117 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 682.6505 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 167.4941 682.6505 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 289.3839 682.6505 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 411.2736 682.6505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 652.2392 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 651.9892 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 602.3779 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 167.4941 651.9892 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 602.3779 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 289.3839 651.9892 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 602.3779 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 411.2736 651.9892 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 602.3779 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 524.6594 602.3779 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 602.1279 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 571.7166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 167.4941 602.1279 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 571.7166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 289.3839 602.1279 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 571.7166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 411.2736 602.1279 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 571.7166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 571.7166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 571.4666 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 502.6553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 167.4941 571.4666 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 502.6553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 289.3839 571.4666 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 502.6553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 411.2736 571.4666 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 502.6553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 524.6594 502.6553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 70.8661 502.4053 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 71.1161 462.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 167.4941 502.4053 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 167.4941 462.394 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 289.3839 502.4053 cm 0 0 m 121.89 0 l S Q q 1 0 0 1 289.3839 462.394 cm 0 0 m 0 39.761 l S 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(\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 )Tj 0 Tw T* (\r\024\030\026\f\021\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 724.8299 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.007 Tw 10 0 0 10 274.9606 700.4739 Tm [(\200 \002\026\026\b \007\026\027\027\t\b El)-31(ibr)-33(ar)-23.9(y.r)-22(u, P)20(ubMed, Medl)-31(ine, \002\t\035 \023\030\024)]TJ 0 Tw (-)Tj -0.038 Tw T* (\r\036\007\036\027 \023\024\017\f\022 \027\026\031\004\027\t\b \f\021\026\ \021\036\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \024\f\035\024\032\027\036\027\027\024)Tj 0 Tw (-)Tj 0.018 Tw T* (\020\024 \030\026\022\026 \035\036\r\024\005 \023\024\035\024\r\017\027\t\ \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b )Tj 0.202 Tw T* (\023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2008 )Tj 0.179 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (2023 \020\020. \215\024\f\022\024\035\034\022\031 \007\026\027\027\026\016\ \021\036\n\026\021\017\022\026 \024\b\r\026\021\t\r\026\036\021 )Tj 0.316 Tw 0 -1.218 TD (\023\030\024\002\035\036\n\t \035\036\004\036\027\017\016 \024\f\035\024\ \032\027\036\027\027\024\020\024 \022\024\035\024\030\036\022\021\026\035\ \034\027\024\020\024 )Tj 0.044 Tw 0 -1.218 TD (\030\026\022\026 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026, \021\ \024 \023\036\030)Tj 0 Tw (-)Tj -0.053 Tw T* (\r\024\027\026\004\026\035\034\027\026\016 \f\021\030\026\021\036\020\017\ \016 \023\024\017\f\022\026 \002\t\035\026 \024\002\001\017\030\027\024\005\ . \215\024\017\f\022 )Tj 0.08 Tw T* (\024\f\031\013\036\f\021\r\035\016\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\036\n \035\024\020\017\004\036\f\022\017\ \b $Bo)-16(olean$ )]TJ -0.054 Tw T* (\024\023\036\030\026\021\024\030\024\r [\030\026\022 \021\024\035\f\021\024\ \005 \022\017\001\022\017 \230\214\230 \030\026\022 \021\024\035\f\021\024\ \005 \022\017\001)Tj 0 Tw (-)Tj 0.133 Tw 0 -1.218 TD (\022\017 \230\214\230 \024\002\f\021\030\031\022\006\017\016] \230)Tj /Span<>> BDC ( )Tj EMC ([\023\026\006\017\036\027\021\t \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030)Tj 0 Tw (-)Tj 0.41 Tw 0 -1.218 TD (\004\036\f\022\024\020\024 \r\024\030\026\f\021\026*]. \025\030\017\021\ \036\030\017\017 \r\022\035\033\004\036\027\017\016: \035\033\002\t\036 \ )Tj 0.21 Tw 0 -1.218 TD (\f\021\026\021\034\017, \030\026\f\f\n\026\021\030\017\r\026\033\013\017\ \036 \r\026\030\017\026\027\021\t \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 )Tj 0.257 Tw 0 -1.218 TD (\035\036\004\036\027\017\016 \035\036\r\024\f\021\024\030\024\027\027\036\ \005 \024\f\021\030\024\005 \024\002\021\031\030\026\006\017\024\027\027\ \024\005 \027\036)Tj 0 Tw (-)Tj 0.035 Tw 0 -1.218 TD [(\023\030\024\b\024\007\017\n\024\f\021\017, )0.6(\r\024\027\017\022\001\036\005 )0.6(\022\026\022 )0.5(\024\f\035\024\032\027\036\027\017\036 )0.5(\030\026\022\026 )0.6(\024\002\024)]TJ 0 Tw (-)Tj 0.033 Tw 0 -1.218 TD (\007\024\004\027\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f)Tj 0 Tw (-)Tj 0.107 Tw 0 -1.218 TD (\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n \016\t\022\026\b. \215\036\030\r\024\ \027\026\004\026\035\034\027\024 )Tj 0.332 Tw 0 -1.218 TD (\023\024\035\031\004\036\027\027\t\036 \f\021\026\021\034\017 \023\030\024\ \r\036\030\016\035\017\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\035\036\r\026\027\021\027\024\f\021\034 )Tj 0.048 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\r\026\027\017\033, \022\035\033\004\036\r\t\n \f\035\024\r\026\ \n \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\030\031 \026\027\027\024\021\026\006\017\017. )Tj 0.243 Tw 0 -1.218 TD (\003\026\021\036\n \r\t\002\030\026\027\027\t\036 \f\021\026\021\034\017\ \002\t\035\017 \023\024\035\031\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n )Tj 0.182 Tw 0 -1.218 TD (\021\036\022\f\021\036 \017)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\t. \225\023\017\f\022\017 \f\f\t\035\024\022 \002\t\ \035\017 \030\036\022\031\030\f\017\r\027\024 )Tj 0.181 Tw 0 -1.218 TD (\023\030\024\026\027\026\035\017\017\030\024\r\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021 \007\024\023\024\035\027\017\021\036\035\034\027\ \t\b \030\036)Tj 0 Tw (-)Tj 0.043 Tw T* [(\035\036\r\026\027\021\027\t\b )0.6(\f\021\026\021\036\005. )0.5(\212\024\023\024\035\027\017\021\036\035\034\027\t\005 )0.6(\023\024\017\f\022 )0.5(\021\026\022\032\036 )0.6(\002\t\035 )]TJ 0.02 Tw T* (\023\030\024\r\036\007\036\027 \r)Tj /Span<>> BDC ( )Tj EMC [(Go)-15.9(o)-16(gle S)-24(chol)-15.9(ar. \207\035\024\022-\f\b\036\n\026 \f\021\030\026\021\036\020\017\017 \023\ \024)]TJ 0 Tw (-)Tj 0.013 Tw T* (\017\f\022\026 \023\030\036\007\f\021\026\r\035\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\017\f. 1. \230\031\004\036\027\024 32 \024\021\036\004\036\f\021\r\ \036\027)Tj 0 Tw (-)Tj T* (\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (52 \026\030\031\002\036\032\027\t\b \017\f\021\024\004\027\017\022\024\r\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 359.4898 Tm [(\033\034\020)21(\223)50(\r\236)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.441 Tw 10 0 0 10 274.9606 335.1338 Tm [(\230\f\023\024\035\034\031\036\n\026\016 \f\021\030\026\021\036\020\017\ \016 )0.5(\023\024\017\f\022\026 \023\024\r\024\035\017\035\026 \027\026\005\021\017\ )]TJ 0.002 Tw T* (543)Tj /Span<>> BDC ( )Tj EMC (\030\036\033\n\036. \230)Tj /Span<>> BDC ( )Tj EMC (\027\017\b 389 \027\036 \f\024\024\021\r\036\021\f\021\r\024\r\026\035\017\ \022\030\017\021\036\030\017)Tj 0 Tw (-)Tj 0.019 Tw T* [(\016\n )0.5(\r\022\035\033\004\036\027\017\016. )0.6(\230)]TJ /Span<>> BDC ( )Tj EMC 7.669 0 Td [(\026\027\026\035\017\026 )0.6(154 \f\021\026\021\036\005 )0.6(\002\t\035\017 )0.5(\017\f\022\035\033\004\036)]TJ 0 Tw (-)Tj 0.103 Tw -7.669 -1.218 Td (\027\t \f\021\026\021\034\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\031 \023\030\016\n\024\005 \022\017\001\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \023\026\006\017)Tj 0 Tw (-)Tj 0.004 Tw T* (\036\027\021\024\r, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024\ , \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (60 \035\036\021 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\021\034\017 )Tj 0.483 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \023\026\006\017\036\027\021\024\r \030\026\ \022\024\n \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 )Tj 0.319 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\007\017\f\f\036\n\017\027\017\030\024\r\026\027\027\t\n )0.5(\023\030\024\006\036\f\f\024\n. \224\026\022\017\n \024\002\030\026\024\ \n, )]TJ 0.206 Tw T* (84)Tj /Span<>> BDC ( )Tj EMC 1.438 0 Td [(\f\021\026\021\034\017 )0.5(\002\t\035\017 )0.6(\r\022\035\033\004\036\027\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.11 0 Td [(\023\024\035\027\t\005 )0.5(\024\002\024\030, )0.6(\f\f\t\035\022\017 )]TJ 0 Tw -12.548 -1.218 Td (\023\030\017\r\036\007\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b [1\22650].)Tj 0.353 Tw T* (\211\035\031\004\001\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r \220\022\f\021\030\036\027\027\024\005 \b\017\030\031\030\020\017\004\ \036\f\022\024\005 )Tj 0.126 Tw T* (\023\024\n\024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\026\022\026 \035\036\r\024\005 \023\024\ \035\024\r\017\027\t \024\002\024\007\024\004)Tj 0 Tw (-)Tj 0.176 Tw T* (\027\024\005 \022\017\001\022\017, \024\f\035\024\032\027\036\027\027\024\ \020\024 \024\f\021\030\024\005 \022\017\001\036\004\027\024\005 \027\036\ \023\030\024)Tj 0 Tw (-)Tj 0.228 Tw T* [(\b\024\007\017\n\024\f\021\034\033, )0.6(\017\n\036\036\021 )0.5(\002\024\035\034\001\024\036 )0.5(\027\026\004\036\027\017\036 )0.6(\007\035\016 )0.5(\f\017\f\021\036\n\t )]TJ 0.188 Tw T* (\007\030\026\r\024\024\b\030\026\027\036\027\017\016, \027\024 \021\026\ \022\021\017\022\026 \035\036\004\036\027\017\016 \023\024-\023\030\036\032\ \027\036\n\031 )Tj 0.175 Tw T* (\024\f\021\026\036\021\f\016 \f\023\024\030\027\024\005. \225\031\013\036\ \f\021\r\031\036\021 \027\036\f\022\024\035\034\022\024 \r\026\030\017\026\ \027\021\024\r )Tj 0.188 Tw T* (\035\036\004\036\027\017\016, \022\024\021\024\030\t\036 \r\022\035\033\004\ \026\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016: $I$ \007\036\022\024\n\023\030\036\f)Tj 0 Tw (-)Tj 0.011 Tw T* (\f\017\024\027\027\t\036 \022\024\035\024\f\021\024\n\t; $II$ \023\036\ \030\r\017\004\027\031\033 \030\036\036\022\006\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027)Tj 0 Tw (-)Tj 0.129 Tw T* (\006\036\r\024\005 \022\024\035\024\f\021\024\n\024\005 $\024\023\036\030\ \026\006\017\016 \206\026\030\021\n\026\027\026$; $III$ \024\007\027\024\ )Tj 0 Tw (-)Tj 0.106 Tw T* [(\n\024\n\036\027\021\027\031\033 \030\036\036\022\006\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \026\027\026\f\021\024\n\024\ \026, )Tj 0.185 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \f\031\002\021\024\021\026\035\034\027\024\005 \022\024\035\ \220\022\021\024\n\017\017 \017\035\017 \f\036\020\n\036\027\021\026\030\ \027\024\005 )Tj 0.329 Tw T* (\022\024\035\220\022\021\024\n\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \021\ \024\035\f\021\024\022\017\001\036\004\027\024\005 )Tj -0.074 Tw T* [(\017\030\030\017\020\026\006\017\036\005 )0.5(\017\035\017 )0.5(\002\036 )0.5(\027\036\036; )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.861 0 Td [($IV$ )0.5(\f\021\036\027\021\017\030\024\r\026\027\017\036 )0.6(\021\024\035\f\021\024\005 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.5395 56.0378 Tm (137)Tj ET endstream endobj 84 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 645.5841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 645.5841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 617.9763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 617.9763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 563.907 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.007 Tw 9 0 0 9 119.0551 730.4919 Tm [(morbidity)42.1(, mor)-40(tality and late oncological outcomes. A cur)-16(rent solution to the p)46(roblem can be tem)16(porar)-43(y decom)16(p)45.9(res)]TJ 0 Tw (-)Tj 0.068 Tw 0 -1.111 TD [(sion of the bow)12(el. The literature demonstrates adv)16(antag)12.1(es of div)13(er)-40(ting colostom)11(y at the f)-42.9(irst stag)12(e in decrease in )]TJ 0.009 Tw T* [(per)-37(ioperativ)13.1(e mor)-40(tality)42.1(, an im)16(p)46(rov)13(ement in the q)14(uality of life due to a decreased morbidity and mor)-40(tality rate, good )]TJ 0 Tw T* (oncological.)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 685.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( malignant larg)12(e bow)12(el obstruction, emerg)12(ency surg)12(er)-43(y)42(, div)13(er)-40(ting colostom)11.1(y)41.9(, elderly and octog)12(enar)-37(ians patients)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interests)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FIN)16(A)31(N)23(CIN)23(G:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.966 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC (authors declare no funding)Tj /T1_1 1 Tf 0.037 Tc 0.059 Tw -4.966 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.068 Tw 6.503 0 Td [( Ef)-47.6(r)-15.8(o)-9.2(n)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)15(G)-11.6(.)-23.5(, S)-10.3(h)-10.5(c)-10.2(h)-8.3(a)-15(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-1.9(N)-2.8(.)-23.5(, V)12.1(o)-15.6(l)-8.3(y)-27.4(n)-16.2(e)-22.3(t)-48.9(s)]TJ /Span<>> BDC ( )Tj EMC [(L)-29.5(.)-9.8(I)-10.3(. S)-12.1(u)-7.6(r)-16.7(g)-28.9(i)-5(c)-21.5(a)-11.4(l a)-8.8(p)-12.3(p)-13.7(r)-15.8(o)-18.2(a)-11.1(c)-10.2(h f)-25.2(o)-11.8(r a)-11.1(c)-12.1(u)-16.3(t)-24.7(e c)-6.5(o)-15.6(l)-20.9(o)-9.2(n t)-22.3(u)-7(m)-12.4(o)-11.8(r o)-11.6(b)-17.7(s)-29.3(t)-30.8(r)-30.3(u)-6.5(c)-41.5(t)-46.2(i)-6.8(o)-9.2(n i)-3.2(n e)-18(l)-25.1(d)-15.3(e)-12.1(r)-32.6(l)-8.3(y a)-7.6(n)-14.5(d o)-16.8(c)-41.5(t)-21.9(o)]TJ 0 Tc 0 Tw 49.833 0 Td (-)Tj 0.026 Tc -0.046 Tw -56.341 -1.2 Td [(g)-3.2(en)3.4(a)0.9(r)-45.2(i)6(a)3.6(n)10.8( p)-8.8(a)-7(t)-35.1(ien)-6.1(t)-37.8(s)10.9( $)50.4(r)-8(e)-4.6(v)-40.7(ie)-1.3(w)30.7($)21.6(.)10.8( )]TJ /T1_0 1 Tf 0.021 Tc -0.021 Tw [(K)10.1(o)-4(lo)-3.9(p)-1.5(r)-0.7(ok)-23(t)-1.7(o)-3.9(lo)-7.2(g)-17(i)2.8(a)2(.)]TJ /T1_2 1 Tf 0.015 Tc -0.035 Tw 18.714 0 Td [( 2)-8.7(0)-3.7(2)-1.3(5)23.5(;)9.9(2)9(4)-13.3($)37.8(1)44.5($)14.6(:)21.1(1)-7.8(3)13.7(5)-22.6(\226)51(1)12.6(4)-38.1(4)-0.9(. $)-0.8(i)-3(n R)-6.4(u)-21.7(s)-22.2(s)-15.3(.)43.3($)10.6(. h)-17.1(t)-49.2(t)-29.3(p)-18.5(s)-7.9(:)2.1(/)84.8(/)36.6(d)-10.9(o)-12.4(i.)2.8(o)-11.6(r)-16.6(g)-22.6(/)11.3(1)14.2(0)6.6(.)-5.4(3)8(3)-15.7(8)1.4(7)4.8(8/)8.1(2)-8.8(0)9.5(7)-1.8(3)-13.1(-)41.3(7)10.9(5)0.6(5)-8.8(6)-26.6(-)9.9(2)-8.8(0)-3.6(2)-1.2(5)-23.4(-)9.9(2)8.9(4)-28.3(-)55.2(1)27.1(-)55.2(1)-7.7(3)13.6(5)-23.3(-)55.2(1)12.7(4)-38.2(4)]TJ /T1_1 1 Tf 0.01 Tc -0.016 Tw -18.709 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \215\030\027\030\215\032\026\037\032:)]TJ /T1_0 1 Tf 0 Tc -0.011 Tw 10.508 0 Td [( \246\037\016\036\037 )0.5(\002\036\016\035\027\037\020\037 )0.5(\222\022\021\034\027\037\016\036\020\037, )0.5(\233\231\230\211\207 )0.5(\215\211 \253\002\b\034\027\016\020\024\021\022\t )0.5(\013\034\024\023\005\037\033\024\035\036\016\020\020\032\t )0.5(\b\016\005\022\006\022\020\024\021\022\t \023\020\022\036\016\033\024\022\ \035\016\035\273 )0.5(\240\022\020\031\005\033\037\036\037 )]TJ 0.023 Tw -10.513 -1.2 Td (\255\034\024\024\022\022, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\r\033\023\f\024\021\034\t, \005.)Tj /Span<>> BDC ( )Tj EMC (28, \002\b\034\027\016\020\024\021, 214019, \255\034\024\024\022\030;)Tj /Span<>> BDC ( )Tj EMC (+79107132726; e-mail: facul.hir.conferens@yandex.ru)Tj /T1_1 1 Tf 0.016 Tc 0.345 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.5(F)12.9(OR)4.9( )0.5(C)19(ORRESPONDEN)22.9(CE:)]TJ /T1_0 1 Tf 0.006 Tc 0.35 Tw 14.867 0 Td [( )0.5(Sv)13(etlana )0.5(N)27.9(. )0.5(Shchaev)15.9(a, )0.5(Smolensk )0.5(S)28(tate )0.5(Medical )0.5(U)21.9(niv)12.9(ersity)41.9(, )0.5(Krupsk)11(aya st., 28, )0.5(Smolensk, )0.5(214019,)6( )]TJ 0 Tc 0.023 Tw -14.872 -1.2 Td [(R)22(ussia;)]TJ /Span<>> BDC ( )Tj EMC [(+79107132726; e-mail: facul.hir)51(.conferens@yande)-14.8(x.ru)]TJ 0 Tw 0 -2.792 TD (\203\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 26.11.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\201\034\024\027\016 \005\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 26.12.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\201\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 26.11.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 26.12.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 505.6259 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.62 Tw 10 0 0 10 70.8661 481.2699 Tm (\210\f\021\030\026\016 \024\002\021\031\030\026\006\017\024\027\027\026\016\ \027\036\023\030\024\b\024\007\017\n\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\017)Tj 0 Tw (-)Tj 0.291 Tw 0 -1.218 TD (\002\024\035\036\036 \004\026\f\021\024\036 \024\f\035\024\032\027\036\027\ \017\036 \030\026\022\026 \024\002\024\007\024\004\027\024\005 \022\017\001\ \022\017.)Tj /T1_4 1 Tf 0 Tw ( )Tj /T1_2 1 Tf -0.027 Tw T* [(\200\f\021\030\036\004\026\036\n\024\f\021\034 )0.6(\007\026\027\027\024\020\024 )0.5(\024\f\035\024\032\027\036\027\017\016 )0.6(\f\024\f\021\026\r\035\016\036\021 )0.6(\024\021 )0.5(8% )]TJ 0.055 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (59% [1]. \203\036\023\030\024\b\024\007\017\n\024\f\021\034 \022\017\001\ \036\004\027\017\022\026 \004\026\013\036 \r\f\021\030\036)Tj 0 Tw (-)Tj 0.158 Tw T* [(\004\026\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.991 0 Td [(\024\023\031\b\024\035\016\b )0.6(\027\017\f\b\024\007\016\013\036\005 )0.6(\024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017 )]TJ -0.025 Tw -4.991 -1.218 Td (\017-\026 \n\036\027\034\001\036\020\024 \007\017\026\n\036\021\030\026\ \035\036\r\024\005 \023\024\035\024\r\017\027\t \024\002\024\007\024\004\ \027\024\005 )Tj 0.113 Tw T* (\022\017\001\022\017. \210\002\f\021\030\031\022\021\017\r\027\t\005 \030\ \026\022 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\016)Tj 0 Tw (-)Tj 0.15 Tw T* (\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\n \024\f\035\024\032\027\036\027\017\016 \024\002\t\004\027\024\ \021\030\036\002\031\033\021 \f\030\024\004\027\024)Tj 0 Tw (-)Tj 0.42 Tw T* (\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\ \026\021\036\035\034\f\021\r\026, \021\026\022 \022\026\022 \024\022\024\ \035\024 )Tj 0.123 Tw T* [(35% \f\035\031\004\026\036\r )0.5(\r\024\027\017\022\026\033\021 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\026\023\031\013\036\027\027\t\n, )Tj 0.414 Tw T* [(\n\036\021\026\f\021\026\021\017\004\036\f\022\017\n )0.5(\017\035\017 \027\036\024\023\036\030\026\002\036\035\034\027\t\n )0.5(\030\026\022\024\n [2]. )]TJ 0.047 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\024\022\026\026\021\036\035\017\ \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\ \024\032)Tj 0 Tw (-)Tj 0.066 Tw T* (\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\016\b \220\022\f\021\030\036\027\027\024\005 \b\017\030\ \031\030\020\017\017 )Tj 0 Tw T* (\024\004\036\027\034 \r\t\f\024\022\017 [3\2265].)Tj 0.014 Tc 0.013 Tw T* (\210\022\024\035\024 15% \r\f\036\b \023\026\006\017\036\027\021\024\r, \ \f\021\030\026\007\026\033\013\017\b \030\026\022\024\n \024\002\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc -0.025 Tw T* (\007\024\004\027\024\005 \022\017\001\022\017, \017\n\036\033\021 \024\f\ \035\024\032\027\036\027\027\024\036 \021\036\004\036\027\017\036 \026\002\ \024\035\036)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.078 Tw T* (\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \024\f\021\030\024\005 \024\002\021\031\030\026\006\017\024\ \027\027\024\005 \027\036\023\030\024\b\024\007\017\n\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc 0.033 Tw T* (\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\024 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \f\021\026\030\001\036 75)Tj /Span<>> BDC ( )Tj EMC [(\035\036\021)14( )]TJ 0.797 Tw T* [([6\2268]. \210\f\021\030\026\016 \024\002\021\031\030\026\006\017\024\027\ \027\026\016 \027\036\023\030\024\b\024\007\017\n\024\f\021\034)14( )]TJ 0.343 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(60% \016\r\035\016\036\021\f\016 \024\f\027\024\r\027\024\005 \023\030\017\ \004\017\027\024\005 \220\022\f\021\030\036\027\027\t\b)14( )]TJ 0.039 Tw T* (\020\024\f\023\017\021\026\035\017\026\006\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024)Tj 0 Tc 0 Tw (-)Tj 0.014 Tc T* (\030\026\f\021\026 [9].)Tj 0 Tc 0.322 Tw T* [(\224\036\027\007\036\027\006\017\016 )0.5(\f\021\026\030\036\027\017\016 \027\026\f\036\035\036\027\017\016 \024\f\ \024\002\036\027\027\024 \026\022\021\031\026\035\034)]TJ 0 Tw (-)Tj 0.143 Tw T* [(\027\026 )0.5(\007\035\016 \217\024\f\f\017\017, \020\007\036 )0.5(\030\024\f\021 )0.5(\007\024\035\017 \035\017\006 )0.5(\f\021\026\030\001\036\020\024 )0.5(\r\024\030\026\f)]TJ 0 Tw (-)Tj 0.135 Tw T* (\021\026 \024\023\036\030\036\032\026\036\021 \030\024\f\021 \004\017\f\035\ \036\027\027\024\f\021\017 \027\026\f\036\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n. )Tj 0.199 Tw T* (\217\026\022 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \ \026\027\017\n\026\036\021 \035\017\007\017\030\031\033\013\017\036 \023\ \024\017)Tj 0 Tw (-)Tj 0.184 Tw T* (\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\002\024\035\036\r\026\036\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\027\024\f\021\017 \f\030\036\007\017 \007\030\031\020\017\ \b )Tj 0.125 Tw T* (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \024\023\031\b\024\035\ \036\005. \203\036\030\036\007\022\024 \030\026\022 \024\002\024\007\024\ \004\027\024\005 )Tj 0.246 Tw T* (\022\017\001\022\017 \030\026\f\f\n\026\021\030\017\r\026\033\021 \022\026\ \022 \253\002\024\035\036\027\034 \006\017\r\017\035\017\026\006\017\017\ \273, )Tj -0.033 Tw T* (\f\r\016\026\027\027\031\033 \f)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\036\n \023\030\024\007\024\035\032\017\ \021\036\035\034\027\024\f\021\017 \032\017\027\017, )Tj 0.027 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\016 \030\026\022\026 \024\002\024\007\024\004\ \027\024\005 \022\017\001\022\017 \016\r\035\016\036\021\f\016 \b\017\030\ \031\030\020\017)Tj 0 Tw (-)Tj 0.116 Tw T* (\036\005, \027\026\017\002\024\035\036\036 \004\026\f\021\024 \r\t\023\024\ \035\027\016\036\n\024\005 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\032\017\035\t\b \035\033\007\036\005. )Tj 0.028 Tw T* (\215\026\006\017\036\027\021\t \220\021\024\005 \022\026\021\036\020\024\ \030\017\017 \022\030\026\005\027\036 \n\026\035\024 \023\030\036\007\f\021\ \026\r\035\036\027\t )Tj 0.164 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\031\004\027\t\b \017\f\f\035\036\007\024\r\026\027\017\016\b, \024\ \023\031\002\035\017\022\024\r\026\027\027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\031 )Tj 0.195 Tw 23.244 42.623 Td (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017, \027\036\f\n\024\ \021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \024\027\017 \f\024\f\021\026\r)Tj 0 Tw (-)Tj 0.296 Tw T* [(\035\016\033\021 )0.6(\002\024\035\034\001\017\027\f\021\r\024 )0.5(\f\030\036\007\017 )0.5(\002\024\035\034\027\t\b )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 16.403 0 Td (\026\023\031\013\036\027\027\t\n\017 )Tj 0.232 Tw -16.403 -1.218 Td [(\235\024\030\n\026\n\017 \026\002\024\035\036\r\026\027\017\016, \027\031\ \032\007\026\033\013\017\b\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\036\027\027\024\005 )Tj 0.286 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017,\ \035\036\004\036\027\017\036 \022\024\021\024\030\t\b \007\026\036\021 \ \027\036)Tj 0 Tw (-)Tj 0.381 Tw T* (\031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\t\036 \030\036\ \031\035\034\021\026\021\t [10\22614]. \200\t\f\024\022\026\016 )Tj -0.044 Tw T* (\f\021\036\023\036\027\034 \022\024\n\024\030\002\017\007\027\024\f\021\017\ , \024\020\030\026\027\017\004\036\027\027\t\036 \235\031\027\022\006\017\ \024\027\026\035\034)Tj 0 Tw (-)Tj 0.123 Tw T* [(\027\t\036 )0.5(\030\036\036\030\r\t )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.633 0 Td [(\235\017\017\024\035\024\020\017\004\036\f\022\017\036 )0.5(\024\f\024\002\036\027\027\024\f\021\017 )0.6(\024\030\020\026)]TJ 0 Tw (-)Tj 0.034 Tw -6.633 -1.218 Td (\027\017\n\026 \035\017\006 \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026, \026\ )Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.184 Tw T* (\f\027\017\032\036\027\027\026\016 \022\024\n\023\035\026\036\027\021\027\ \024\f\021\034 \027\026\004\017\021\036\035\034\027\024 \031\f\035\024\032\ \027\016\033\021 )Tj 0.239 Tw T* [(\035\036\004\036\027\017\036 )0.6(\024\002\021\031\030\026\006\017\024\027\027\024\005 )0.5(\022\017\001\036\004\027\024\005 )0.5(\027\036\023\030\024\b\024\007\017\n\024\f\021\017 )]TJ 0 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \023\026\006\017\036\027\021\024\r.)Tj 0.131 Tw T* (\200\026\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \030\017\ \f\022 \023\024\035\027\024\005 \024\002\f\021\030\031\022\006\017\017 \f\ \031\013\036)Tj 0 Tw (-)Tj 0.441 Tw T* (\f\021\r\036\027\027\024 \r\t\001\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\017 \035\024\022\026\004\036\f\021\ \r\036\027\027\024\005 )Tj 0.021 Tw T* (\024\023\031\b\024\035\017 \r)Tj 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)0.6(\023\021\037\031\032\036\037\016\035 )0.5(\020\037)]TJ /Span<>> BDC ( )Tj EMC 9.44 0 Td [(\f\033\016\022\b\023\217\016\024\035\036\037 )0.6(\017\034\033\b\022\033\034\036\037\020\022\030 )0.7(\005\016\021\034\b\f\033\016\024\024\022\034\020\020\034\t )0.5(\021\034\027\034\024\035\034\b\032 )0.5(\020\037)]TJ /Span<>> BDC ( )Tj EMC 27.328 0 Td [(\f\016\033\036\034\b )0.6(\220\021\024\035\033\016\020\020\034\b )]TJ 0.112 Tw -36.768 -1.111 Td (\220\035\037\f\016 \036)Tj /Span<>> BDC ( )Tj EMC (\027\016\n\016\020\022\022 \034\025\024\035\033\023\021\035\022\036\020\034\ \013\034 \033\037\021\037 \027\016\036\034\t \f\034\027\034\036\022\020\032\ \034\025\034\005\034\n\020\034\t \021\022\004\021\022 \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\006\022\016\020\035\034\036 \f\034\003\022\027\034\013\034 \022)Tj /Span<>> BDC ( )Tj EMC (\024\035\037\033)Tj 0 Tw (-)Tj 0.18 Tw T* (\n\016\024\021\034\013\034 \036\034\031\033\037\024\035\037, \035\037\021\ \021\037\021 \005\037\020\020\032\t \f\034\005\001\034\005 \024\034\f\033\ \034\036\034\003\005\037\016\035\024\030 \024\020\022\003\016\020\022\016\ \b \f\016\033\022\034\f\016\033\037\006\022\034\020\020\034\t \027\016\035\ \037\027\007\020\034\024\035\022, )Tj -0.027 Tw 0 -1.111 TD [(\023\027\023\n\004\016\020\022\016\b )0.6(\021\037\n\016\024\035\036\037 )0.6(\003\022\031\020\022 )0.6(\031\037)]TJ /Span<>> BDC ( )Tj EMC 13.144 0 Td [(\024\n\016\035 )0.6(\024\020\022\003\016\020\022\030 )0.6(\f\034\035\033\016\025\020\034\024\035\022 )0.6(\036)]TJ /Span<>> BDC ( )Tj EMC 12.982 0 Td [(\f\034\024\035\034\030\020\020\032\001 )0.5(\024\035\034\b\037\001, )0.5(\001\034\033\034\004\022\b\022 )0.5(\034\035\005\037\027\016\020\020\032\b\022 )]TJ 0.023 Tw -26.125 -1.111 Td (\034\020\021\034\027\034\013\022\n\016\024\021\022\b\022 \033\016\031\023\ \027\007\035\037\035\037\b\022)Tj /Span<>> BDC ( )Tj EMC (\227 \f\034\021\037\031\037\035\016\027\030\b\022 3-\001 \027\016\035\020\ \016\t \034\025\217\016\t \036\032\003\022\036\037\016\b\034\024\035\022\ .)Tj /T1_2 1 Tf 0.01 Tc 0.065 Tw 8 0 0 8 42.5596 355.3797 Tm [(\037\033\255\200\030\025\202\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.07 Tw 8.54 0 Td ( \033\037\021 \034\025\034\005\034\n\020\034\t \021\022\004\021\022, \021\ \022\004\016\n\020\037\030 \020\016\f\033\034\001\034\005\022\b\034\024\035\ \007, \220\021\024\035\033\016\020\020\037\030 \001\022\033\023\033\013\022\ \030, \005\016\021\034\b\f\033\016\024\024\022\034\020\020\037\030 \024\035\ \034\b\037, \025\034\027\007\020\032\016 \f\034\003\022)Tj 0 Tw (-)Tj 0.023 Tw -8.545 -1.2 Td (\027\034\013\034 \022)Tj /Span<>> BDC ( )Tj EMC (\024\035\037\033\n\016\024\021\034\013\034 \036\034\031\033\037\024\035\037\ )Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\034\032\035\021\035\026\032\027\036\025\021\035\032\030:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \022\024\024\027\016\005\034\036\037\020\022\016 \f\033\034\036\016\005\ \016\020\034 \025\016\031 \024\f\034\020\024\034\033\024\021\034\t \f\034\ \005\005\016\033\003\021\022)Tj /T1_2 1 Tf 0.033 Tc 0.092 Tw -8.655 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.023 Tc 0.097 Tw 9.264 0 Td ( \237\235\030\024\027)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \236\026\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\225.\203., \200\024\035\t\027\036\006)Tj /Span<>> BDC ( )Tj EMC (\214.\230. \216\017\030\031\030\020\017\004\036\f\022\026\016 \021\026\022\ \021\017\022\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\024\f\021\030\024\005 \024\002\021\031\030\026\006\017\024\027\027\024\005\ \027\036\023\030\024\b\024\007\017\n\024\f\021\017)23( )]TJ 0.017 Tc -0.035 Tw -9.269 -1.2 Td [(\024\023\031\b)0.5(\024\035\036\r\024\020\024 \020\036\027\036\026 \031)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \023\024\032\017\035\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\030\004\036\f\022\024\020\024 \r\024\030\026\f\021\026 $\024\ \002\024\030 \035\017\021\036\030\026\021\031\030\t$. )Tj /T1_1 1 Tf -0.017 Tw [(\r\034)0.5(\027\034\f\033\034\021\035\034\027\034\013\022\030.)]TJ /T1_3 1 Tf -0.035 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(135\226144.)17( )]TJ 0.023 Tc -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2025-24-1-135-144)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 82.4115 242.7641 Tm [(Sur)31(gical appr)20(oach for acute colon tumor obstr)10.1(uction )]TJ 1.411 -1.167 Td [(in elderly and octogenarian patients $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 197.2601 Tm [(Alek)11(sandr\022)-23.2(G.\022)-23.3(Efr)20(on)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 149.444 201.9221 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 160.7646 197.2601 Tm [(, Sv)12(etlana\022)-23.2(N.\022)-23.3(Shchae)11(v)10(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 292.4594 201.9221 Tm [(1,)-69(4)]TJ 0 Tc 0.023 Tw 14 0 0 14 303.78 197.2601 Tm [(, Larisa\022)-23.2(I.\022)-23.3(V)30(olynets)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 406.5921 201.9221 Tm [(1,)-69(3)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 42.5197 182.9209 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 179.5909 Tm [(Smolensk State Medical Univ)12(er)20(sit)-19.9(y $Kr)10(upskay)21.1(a\022)-23.3(st., 2)35(8, Smolensk, 2)138(1)150(40)87(1)138(9, Russia$)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 170.9209 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 167.5909 Tm [(Smolensk Regional Oncology Clinical Hospital $Mar)20(shal Zh)11(uk)11.1(ov st., 1)138(9, Smolensk 2)138(1)150(4000, Russia$)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 158.9209 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 155.5909 Tm [(Smolensk Regional Clinical Hospital $Gagarin\022)-23.2(st., 2)46(7)127(, Smolensk, 2)138(1)150.1(40)86.9(1)112.1(8, Russia$)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 146.9209 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 143.5909 Tm [(Multidisciplinar)-30.8(y clinic \234Ur)20(omed\236 $Mar)20(shal Sok)11(olov)10(sky\022)-23.2(st., 1)112(8/1)69(, Smolensk, 2)138(1)150(403)138(1)69(, Russia$)]TJ /T1_1 1 Tf 0.073 Tw 9 0 0 9 90.7087 125.087 Tm [(Acute bow)12(el obstruction is the most common com)16(plication of lef)-46(t colon cancer)61(, with the ag)12(e of patients with this )]TJ 0.004 Tw 0 -1.111 TD [(pathology )0.5(in most )0.5(cases being ov)13(er 75 years. The op)13(timal )0.5(surgical app)46(roach in this g)14(roup of patients remains debat)]TJ 0 Tw (-)Tj 0.003 Tw T* [(able. A search of scientif)-42.9(ic studies on the treatment of lef)-46(t-sided malignant obstruction in elderly and octog)12(enar)-37(ian )]TJ -0.006 Tw T* [(patients )0.5(w)13(as done )0.5(in the Elibrar)-42.9(y)32(.ru, )0.5(PubMed, and )0.5(Medline d)26.1(atabases from 2008 to )0.5(2023. T)53(o d)26(ate, there is no ir)-16(refut)]TJ 0 Tw (-)Tj -0.004 Tw T* [(able )0.5(evidence )0.5(to )0.5(suppor)-39.9(t whether )0.5(emerg)12(ency )0.5(surg)12(er)-43(y )0.5(or )0.5(colonic )0.5(stent )0.5(placement is )0.5(op)13(timal treatment )0.5(in ter)-14(ms )0.5(of )0.5(the )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 529.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 520.226 Tm (\027\030\203\255\204\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 133.5913 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 124.664 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4271 56.0378 Tm (135)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 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Di)-16(ver)-22(t)-31.9(icul)-31(i)-24(t)-32(is af)-28(ter fecal micr)-31.9(o)]TJ 0 Tw (-)Tj 0.101 Tw -1.796 -1.25 Td [(bio)17(t)15(a )0.6(tr)-33(anspl)-16(ant )0.6(for )0.5(C. )0.5(dif)-55.9(f)-28(ic)-24(ile )0.6(infec)-16(t)-32(ion. )]TJ /T1_1 1 Tf 17.387 0 Td [(Am )0.6(J )0.5(Gastroenterol)]TJ /T1_0 1 Tf [(. )0.5(2014 )]TJ 0.167 Tw -17.387 -1.25 Td [(Dec;109$12$:1956\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/ajg.2014.350)Tj 0 0 0 1 k /GS1 gs 0.167 Tw ( PMID: 25470590; )Tj 0.023 Tw T* (PMCID: PMC4795814.)Tj 0.003 Tc 0.35 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.809 0 Td (\025\035\017\027\017\004\036\f\022\024\036 \017\f\023\t\021\026\027\017\036\ NCT05373784: \253\217\036\031\035\034\021\026\021\t \021\030\026\027\f\ )Tj 0 Tc 0 Tw (-)Tj 0.003 Tc 0.35 Tw -1.809 -1.25 Td (\023\035\026\027\021\026\006\017\017 \235\036\022\026\035\034\027\024\005\ \n\017\022\030\024\002\017\024\021\t $\224\205\204$ \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\024\f\035\024\032\027\036\027\027\024\n)3( )]TJ 0 Tc T* [(\007\017\r\036\030\021\017\022\031\035\017\021\036: \023\017\035\024\021\ \027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036\273 ht)-30.2(tps://ichgcp.ne)-12.2(t/r)-22.3(u/)]TJ 0.002 Tc 0.349 Tw T* [(cl)-30.7(inical-tr)-36.6(ials-r)-23.6(egistr)-23.6(y/NCT05373784 /Cl)-30.6(inical tr)-36.6(ial NCT05373784:)2( )]TJ 0 Tc 0.152 Tw T* (\233Outcomes of)Tj /Span<>> BDC ( )Tj EMC 5.931 0 Td [(fecal micr)-31.9(obio)17(t)15(a tr)-33(anspl)-15.9(ant)15(a)15(t)-32(ion $FMT$ in uncom)10(pl)-30.9(i)]TJ 0 Tw (-)Tj 0.153 Tw -5.931 -1.25 Td [(ca)15(ted )0.6(di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: )0.6(a)]TJ /Span<>> BDC ( )Tj EMC 9.425 0 Td [(pil)30(o)17(t )0.6(stud)17(y\234. )0.6(ht)-30(tps://ichgcp.ne)-11.9(t/r)-22(u/cl)-31(inical-)]TJ 0 Tw -9.425 -1.25 Td [(tr)-37(ials-r)-23.9(egistr)-23.9(y/NCT05373784)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.8402 56.0378 Tm (134)Tj ET endstream endobj 299 0 obj <>/Border[0 0 0]/H/N/Rect[180.937 708.512 273.969 699.216]/Subtype/Link/Type/Annot>> endobj 300 0 obj <>/Border[0 0 0]/H/N/Rect[220.535 658.512 291.968 649.056]/Subtype/Link/Type/Annot>> endobj 301 0 obj <>/Border[0 0 0]/H/N/Rect[70.8661 648.512 93.242 639.216]/Subtype/Link/Type/Annot>> endobj 302 0 obj <>/Border[0 0 0]/H/N/Rect[98.0624 608.512 196.574 599.216]/Subtype/Link/Type/Annot>> endobj 303 0 obj <>/Border[0 0 0]/H/N/Rect[181.305 578.512 291.968 569.056]/Subtype/Link/Type/Annot>> endobj 304 0 obj <>/Border[0 0 0]/H/N/Rect[318.085 728.512 411.997 719.216]/Subtype/Link/Type/Annot>> endobj 305 0 obj <>/Border[0 0 0]/H/N/Rect[340.279 688.512 433.751 679.216]/Subtype/Link/Type/Annot>> endobj 306 0 obj <>/Border[0 0 0]/H/N/Rect[453.754 678.512 524.409 669.216]/Subtype/Link/Type/Annot>> endobj 307 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 668.512 326.123 659.216]/Subtype/Link/Type/Annot>> endobj 308 0 obj <>/Border[0 0 0]/H/N/Rect[391.706 638.512 464.29 629.216]/Subtype/Link/Type/Annot>> endobj 318 0 obj <> endobj 317 0 obj <> endobj 316 0 obj <> endobj 315 0 obj <> endobj 314 0 obj <> endobj 313 0 obj <> endobj 312 0 obj <> endobj 311 0 obj <> endobj 310 0 obj <> endobj 309 0 obj <> endobj 279 0 obj [319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R] endobj 280 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 335.9485 42.7216 Tm [(F)20(eatur)31(es of\022th)11(e gut micr)20(obiota in th)11(e\022path)11(ogenesis and )]TJ 3.366 -1 Td [(clinical cour)20(se of\022div)12(er)-20(ticular disease $r)31(e)11(vie)11(w$)]TJ -42.49 1 Td [(\033\025\013\n \024\b\007\017\025\210\b\025\026\240 \016\022\223\005\026\ )11(\025\020)10(\f\t\f\001\f \b\022\007)-10(\013\b\t\b\213\f\205\007)10(\025\024 \026)11(\f\213\f\t\b\b )]TJ 0 -1 TD [(\217\b\016\f\017\026\b\007\220\013\017\t\025\255 \210\025\013\f\001\t\b\ $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.05 Tw 8 0 0 8 42.5197 731.2159 Tm (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Fl)30(o)-16(ch)]TJ /Span<>> BDC ( )Tj EMC (MH. A)Tj /Span<>> BDC ( )Tj EMC [(hypo)17(t)-13(hesis: is di)-16(ver)-22(t)-31.9(icul)-31(i)-24(t)-32(is a)]TJ /Span<>> BDC ( )Tj EMC [(t)-10(ype of)]TJ /Span<>> BDC ( )Tj EMC [(infl)-15.9(amma)15(t)17(or)-24(y )]TJ 0.17 Tw -1.796 -1.25 Td [(bo)-14(wel )0.5(disease? )]TJ /T1_2 1 Tf 6.555 0 Td [(J )0.5(Clin )0.5(Gastroenterol.)]TJ /T1_1 1 Tf [( )0.5(2006 )0.5(A)10(ug;40 )0.5(Suppl )0.5(3:S121\2265. )]TJ 0 Tw -6.555 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/01.mcg.0000225502.29498.ba)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 16885694)Tj 0.113 Tw -1.847 -1.25 Td (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-24(ennan)]TJ /Span<>> BDC ( )Tj EMC [(C)19.9(A, Cl)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(SL, L)-32(avoie)]TJ /Span<>> BDC ( )Tj EMC [(SL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj /T1_2 1 Tf [(F)24(usobacter)-36.9(ium nucleatum)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.003 Tc 0.349 Tw -1.796 -1.25 Td [(dr)-36.8(i)-15.7(ves a)]TJ /Span<>> BDC ( )Tj EMC [(p)25.2(r)-31.8(o-infl)-15.8(amma)15.2(t)17.2(or)-23.8(y intest)-31.8(inal micr)-31.8(oenv)-15.8(ir)-31.8(onment t)-12.8(hr)-31.8(ough)3( )]TJ 0 Tc 0.044 Tw 0 -1.25 TD [(me)-12(t)15(abol)-31(i)-23.9(te r)-24(ecept)17(or-dependent modul)-16(a)15(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(IL-17 e)-18(xp)25(r)-23.9(ession. )]TJ /T1_2 1 Tf 0 Tw (Gut )Tj T* (Microbes. )Tj /T1_1 1 Tf 0.127 Tw 4.044 0 Td [(2021 Jan-Dec;13$1$:1987780. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/19490976.20)Tj -4.044 -1.25 Td (21.1987780)Tj 0 0 0 1 k /GS1 gs 0.006 Tc 0.349 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.819 0 Td (Jang)Tj /Span<>> BDC ( )Tj EMC (C, Hui)Tj /Span<>> BDC ( )Tj EMC [(S, L)35.2(u)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47.3(he)]TJ /Span<>> BDC ( )Tj EMC [(Small Intest)-31.7(ine Conver)-21.7(ts)6( )]TJ 0 Tc 0.151 Tw -1.819 -1.25 Td [(Die)-12(t)15(ar)-23.9(y F)10(r)-22(uc)-15.9(t)17(ose int)17.1(o Gl)35(ucose and Or)-32(ganic A)-25(c)-23.9(ids. )]TJ /T1_2 1 Tf (Cell Metab.)Tj /T1_1 1 Tf ( 2018 )Tj 0.294 Tw T* [(F)10(eb 6;27$2$:351\226361.e3. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.cme)-12(t.2017.12.016)]TJ 0 0 0 1 k /GS1 gs 0.294 Tw ( PMID: )Tj 0.023 Tw T* (29414685; PMCID: PMC6032988.)Tj 0.162 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mar)-32(chesi)]TJ /Span<>> BDC ( )Tj EMC 3.963 0 Td [(JR, )0.5(A)15(d)42(ams)]TJ /Span<>> BDC ( )Tj EMC [(DH, )0.5(F)20(av)-15(a)]TJ /Span<>> BDC ( )Tj EMC 8.454 0 Td [(F, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC 5.438 0 Td [(gut )0.5(micr)-32(obio)17(t)15(a )0.5(and )]TJ 0.25 Tw -19.651 -1.25 Td [(host heal)56(t)-13(h: a)]TJ /Span<>> BDC ( )Tj EMC [(new cl)-30.9(inical fr)-32(ont)-32(ier. )]TJ /T1_2 1 Tf 0 Tw (Gut)Tj /T1_1 1 Tf 0.25 Tw [(. 2016 F)10(eb;65$2$:330\2269. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.767 0 Td (10.1136/gutjnl-2015-309990)Tj 0 0 0 1 k /GS1 gs -0.057 Tw ( Epub 2015 Sep 2. PMID: 26338727; )Tj 0.023 Tw -1.767 -1.25 Td (PMCID: PMC4752653.)Tj -0.009 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Sun)Tj /Span<>> BDC ( )Tj EMC [(M, W)15.9(u)]TJ /Span<>> BDC ( )Tj EMC [(W, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(Z, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(obio)17(t)15(a me)-12(t)15.1(abol)-31(i)-24(te shor)-21.9(t chain f)16(a)15(t)-30(t)-9.9(y )]TJ 0.051 Tw -1.796 -1.25 Td [(a)-17(c)-24(ids, GPCR, and infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel diseases. )]TJ /T1_2 1 Tf (J Gastroenterol.)Tj /T1_1 1 Tf ( 2017 )Tj T* [(Jan;52$1$:1\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00535-016-1242-9)Tj 0 0 0 1 k /GS1 gs 0.051 Tw ( Epub 2016 Jul 23. )Tj 0.023 Tw T* (PMID: 27448578; PMCID: PMC5215992.)Tj 0.131 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(omar)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(EW, Br)-33(anch)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, Cummings)]TJ /Span<>> BDC ( )Tj EMC [(JH. Car)-24(bohydr)-33(a)15(te fer)-16(ment)15.1(a)]TJ 0 Tw (-)Tj -0.013 Tw -1.796 -1.25 Td [(t)-32(ion )0.5(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 4.489 0 Td [(human )0.6(col)30(on )0.5(and )0.5(i)-23.9(ts )0.5(r)-24(el)-15.9(a)15(t)-32(ion )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 12.814 0 Td [(a)-17(ce)-12(t)15(a)15(te )0.6(concentr)-33(a)15(t)-32(ions )0.6(in )]TJ 0.032 Tw -17.303 -1.25 Td [(venous bl)30.1(o)-16(od. )]TJ /T1_2 1 Tf [(J Clin In)11(v)13(est.)]TJ /T1_1 1 Tf [( 1985 Ma)15(y;75$5$:1448\22654. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1172/)Tj T* (JCI111847)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 3998144; PMCID: PMC425482.)Tj 0.17 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jung)Tj /Span<>> BDC ( )Tj EMC [(TH, P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC (JH, Jeon)Tj /Span<>> BDC ( )Tj EMC [(WM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. But)-9.9(yr)-33(a)15(te modul)-16(a)15(tes ba)-17(c)-16(te)]TJ 0 Tw (-)Tj 0.274 Tw -1.796 -1.25 Td [(r)-37(ial adher)-23.9(ence on LS174T human col)30(or)-24(ec)-16(t)15(al cells b)12(y st)-32(imul)-15.9(a)15(t)-32(ing )]TJ 0.09 Tw T* [(muc)-24(in secr)-24(e)-11.9(t)-32(ion and MAPK signal)-31(ing p)32(a)15(t)-13(hw)-12(a)15(y. )]TJ /T1_2 1 Tf [(N)21(utr R)21(es Pract.)]TJ /T1_1 1 Tf ( 2015 )Tj 0.096 Tw T* [(A)10(ug;9$4$:343\2269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.4162/nr)-24(p.2015.9.4.343)]TJ 0 0 0 1 k /GS1 gs 0.096 Tw ( Epub 2015 Jul 17. )Tj 0.023 Tw T* (PMID: 26244071; PMCID: PMC4523476.)Tj 0.131 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(childer)-36.9(ink)]TJ /Span<>> BDC ( )Tj EMC [(R, V)30(er)-10(seijden)]TJ /Span<>> BDC ( )Tj EMC (C, Seppen)Tj /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(SCF)24(A but)-10(yr)-33(a)15.1(te )]TJ 0.097 Tw -1.796 -1.25 Td [(st)-32(imul)-15.9(a)15(tes t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(epi)-24(t)-13(hel)-31(ial p)25(r)-32(oduc)-16(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(e)-11.9(t)-32(inoic a)-17(c)-23.9(id v)-15.9(ia inhibi)-23.9(t)-32(ion )]TJ 0.049 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(epi)-24(t)-13(hel)-30.9(ial HD)20(A)16(C. )]TJ /T1_2 1 Tf [(Am J Ph)12(ysiol Gastrointest Liv)13(er Ph)12(ysiol.)]TJ /T1_1 1 Tf ( 2016 Jun )Tj -0.013 Tw T* [(1;310$11$:G1138-46. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1152/ajpgi.00411.2015)Tj 0 0 0 1 k /GS1 gs -0.013 Tw [( Epub 2016 Ma)15(y )]TJ 0.023 Tw T* (5. PMID: 27151945.)Tj 0.083 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chul)56(t)-12.9(hess)]TJ /Span<>> BDC ( )Tj EMC [(J, P)40(ande)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(S, Capi)-23.9(t)15(ani)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(S)-16(hor)-22(t Chain F)20(a)15(t)-30(t)-10(y )]TJ 0.142 Tw -1.796 -1.25 Td [(A)-25(c)-24(id But)-10(yr)-33(a)15(te Im)10(p)25(r)-37(ints an)]TJ /Span<>> BDC ( )Tj EMC [(Ant)-31.9(imicr)-32(obial P)35(r)-32(o)-15.9(gr)-33(am in Ma)-17(cr)-31.9(opha)-17(ges. )]TJ /T1_2 1 Tf 0 Tw T* (Immunity.)Tj /T1_1 1 Tf 0.307 Tw [( 2019 F)10(eb 19;50$2$:432\226445.e7. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.immu)Tj (-)Tj 0.011 Tc -0.011 Tw T* (ni.2018.12.018)Tj 0 0 0 1 k /GS1 gs 0.414 Tw [( Epub 2019 Jan 23. PMID: 30683619; PMCID:)11( )]TJ 0 Tc 0 Tw T* (PMC6382411.)Tj -0.02 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Smi)-24(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(PM, Ho)-14(wi)-23.9(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(MR, P)40(anikov)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he Micr)-32(obial Me)-12(t)15(abol)-31(i)-24(tes, )]TJ 0.258 Tw -1.796 -1.25 Td [(S)-16(hor)-22(t-Chain )0.5(F)20(a)15(t)-30(t)-10(y A)-25(c)-24(ids, )0.5(R)13(egul)-16(a)15(te Col)30(onic T)50(r)-23.9(eg Cell Homeost)15(asis. )]TJ /T1_2 1 Tf 0 Tw T* (Science)Tj /T1_1 1 Tf 0.346 Tw [(. 2013;341 $6145$ $Jul)35(y 4$: 569\226573. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1126/sc)-24(i)]TJ (-)Tj T* (ence.1241165)Tj 0 0 0 1 k /GS1 gs 0.008 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gon\347al)30(ves)]TJ /Span<>> BDC ( )Tj EMC [(P, Ar)-32.9(a\372jo)]TJ /Span<>> BDC ( )Tj EMC [(JR, Di Sant)17.1(o)]TJ /Span<>> BDC ( )Tj EMC (JP. A)Tj /Span<>> BDC ( )Tj EMC [(cr)-32(oss-t)15.1(alk be)-12(t)-32(ween micr)-32(o)]TJ 0 Tw (-)Tj 0.065 Tw -1.796 -1.25 Td [(bio)17(t)15(a-der)-36.9(i)-16(ved shor)-22(t-chain f)16(a)15(t)-30(t)-10(y a)-17(c)-24(ids and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (host mucosal immune )Tj 0.272 Tw T* [(sy)-13(stem r)-24(egul)-16(a)15.1(tes intest)-31.9(inal homeost)15(asis and infl)-15.9(amma)15(t)17(or)-23.9(y bo)-14(wel )]TJ 0 Tw T* (disease. )Tj /T1_2 1 Tf 0.303 Tw 3.786 0 Td [(Inf)-22(lamm Bow)12.1(el Dis.)]TJ /T1_1 1 Tf [( 2018;24$3$:558\226572. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/)Tj -3.786 -1.25 Td (ibd/izx029)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.349 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.807 0 Td [(Ja)-16.7(cobs)]TJ /Span<>> BDC ( )Tj EMC [(DO. Cl)-30.7(inical p)25.3(r)-32.7(a)-16.7(c)-15.6(t)-31.7(ice. Di)-15.6(ver)-21.7(t)-31.7(icul)-30.7(i)-23.7(t)-31.6(is. )]TJ /T1_2 1 Tf [(N Eng)13.3(l J Med.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 25.831 0 Td ( )Tj 0.073 Tw -27.638 -1.25 Td [(2007 N)-14(ov 15;357$20$:2057\22666. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1056/NEJMcp073228)Tj 0 0 0 1 k /GS1 gs 0.073 Tw ( PMID: )Tj 0 Tw T* (18003962.)Tj 0.003 Tc 0.35 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.809 0 Td [(Byndl)29.9(oss)]TJ /Span<>> BDC ( )Tj EMC (MX, Olsan)Tj /Span<>> BDC ( )Tj EMC [(EE, R)-24.2(i)-16.1(ver)-33.1(a-Ch\341vez)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12.1(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32.1(obio)16.9(t)14.8(a-)]TJ 0 Tc 0.272 Tw -1.809 -1.25 Td [(a)-17(c)-16(t)-32(i)-16(v)-14.9(a)15(ted PP)25(AR-\265 signal)-31(ing inhibi)-24(ts d)17(y)-13(sbio)17(t)-32(ic Enter)-32(oba)-17(c)-16(ter)-36.9(ia)-17(ceae )]TJ 0.004 Tc -0.004 Tw T* [(e)-18(xp)32(ansion. )]TJ /T1_2 1 Tf 4.99 0 Td (Science)Tj /T1_1 1 Tf 0.35 Tw [(. )0.6(2017;357$6351$:570\226575. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw 17.383 0 Td [(10.1126/sc)-24(i)]TJ 0 Tc 0 Tw (-)Tj -22.374 -1.25 Td (ence.aam9949)Tj 0 0 0 1 k /GS1 gs 0.008 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gon\347al)30(ves)]TJ /Span<>> BDC ( )Tj EMC [(P, Ar)-32.9(a\372jo)]TJ /Span<>> BDC ( )Tj EMC [(JR, Di Sant)17.1(o)]TJ /Span<>> BDC ( )Tj EMC (JP. A)Tj /Span<>> BDC ( )Tj EMC [(cr)-32(oss-t)15.1(alk be)-12(t)-32(ween micr)-32(o)]TJ 0 Tw (-)Tj 0.065 Tw -1.796 -1.25 Td [(bio)17(t)15(a-der)-36.9(i)-16(ved shor)-22(t-chain f)16(a)15(t)-30(t)-10(y a)-17(c)-24(ids and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (host mucosal immune )Tj 0.272 Tw T* [(sy)-13(stem r)-24(egul)-16(a)15.1(tes intest)-31.9(inal homeost)15(asis and infl)-15.9(amma)15(t)17(or)-23.9(y bo)-14(wel )]TJ 0 Tw T* (disease. )Tj /T1_2 1 Tf 0.303 Tw 3.786 0 Td [(Inf)-22(lamm Bow)12(el Dis.)]TJ /T1_1 1 Tf [( 2018;24$3$:558\226572. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/)Tj -3.786 -1.25 Td (ibd/izx029)Tj 0 0 0 1 k /GS1 gs -0.004 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bar)-24(bar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(G, Cr)-23.9(emon)]TJ /Span<>> BDC ( )Tj EMC [(C, Bar)-23.9(bar)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(MR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)49.9(r)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(Di)-16(ver)-22(t)-31.9(icul)-16(ar )]TJ 0.177 Tw -1.796 -1.25 Td [(Disease W)-16(i)-24(t)-13(h Aminosal)-30.9(icyl)-16(a)15(tes: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Ev)-16(idence. )]TJ /T1_2 1 Tf (J Clin Gastroenterol.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2016;50 Suppl 1:S60\226S63. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MCG.0000000000000611)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.457 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.845 0 Td (\230\r\026\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\224., \204\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\200., \202\002\007\031\035\020\026\027\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\212.\230., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)12( )]TJ 0.009 Tc 0.352 Tw -1.845 -1.25 Td (\215\030\026\022\021\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\ \007\026\006\017\017 \203\026\031\004\027\024\020\024 \f\024\024\002\013\ \036\f\021\r\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\036\005)Tj 0 Tc 0 Tw (-)Tj 0.314 Tw T* (\f\021\r\017\033 \022\035\017\027\017\004\036\f\022\024\n\031 \017\031\004\ \036\027\017\033 \n\017\022\030\024\002\017\024\n\026 \004\036\035\024\r\ \036\022\026 $\203\225\210\230\204$ )Tj 0.122 Tw 29.055 81.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC 0.873 0 Td [(\217\024\f\f\017\005\f\022\024\005 )0.5(\020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\017\004\036\f\ \022\024\005 )0.6(\026\f\f\024\006\017\026\006\017\017 )0.6($\217\206\202$ )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 24.892 0 Td (\023\030\017)Tj 0 Tw (-)Tj 0.288 Tw -25.765 -1.25 Td (\n\036\027\036\027\017\033 \023\030\024\002\017\024\021\017\022\024\r \007\ \035\016 \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022\021\017\022\017 \026\002\024\035\036\r\ \026)Tj 0 Tw (-)Tj 0.305 Tw T* [(\027\017\005 \020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\017\ \004\036\f\022\024\020\024 )0.5(\023\030\024\235\017\035\016 \031)]TJ /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b. )Tj /T1_2 1 Tf 0 Tw (\255\034\024\024\022\t\024\021\022\t )Tj 0.013 Tc 0.471 Tw T* (\003\023\033\020\037\027 \013\037\024\035\033\034\220\020\035\016\033\034\ \027\034\013\022\022, \013\016\f\037\035\034\027\034\013\022\022, \021\034\ \027\034\f\033\034\021\035\034\027\034\013\022\022.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.001 Tc 0.35 Tw -27.638 -1.25 Td [(2020;30$2$:76\22689. / Iv)-15.3(ashk)-16.3(in)]TJ /Span<>> BDC ( )Tj EMC [(V.T., Ma)14.7(yev)]TJ /Span<>> BDC ( )Tj EMC [(I.V., e)-12.4(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)34.7(r)-33.3(a)-17.4(c)-16.3(t)-32.3(ical)1( )]TJ 0 Tc 0.288 Tw T* [(R)13(ecommend)42(a)15(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(S)-24(c)-24(ient)-31.9(if)-28(ic S)-16(o)-16(c)-23.9(ie)-12(t)-10(y for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(S)15(tud)17.1(y of)]TJ /Span<>> BDC ( )Tj EMC (Human )Tj 0.328 Tw T* [(Micr)-32(obiome and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Russian Gastr)-32(oenter)-31.9(ol)30(o)-16(gical Asso)-15.9(c)-24(ia)15(t)-32(ion on )]TJ 0.009 Tc 0.349 Tw T* (Use of)Tj /Span<>> BDC ( )Tj EMC [(P)35.4(r)-31.6(obio)17.4(t)-31.7(ics, P)35.4(r)-23.6(ebio)17.4(t)-31.7(ics, Synbio)17.4(t)-31.7(ics and F)10.3(unc)-15.7(t)-31.6(ional F)10.3(o)-15.7(ods)9( )]TJ 0 Tc 0.332 Tw T* [(in T)50(r)-24(ea)15(tment and P)35(r)-24(event)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(Gastr)-32(oenter)-31.9(ol)30(o)-16(gical Diseases in )]TJ 0.022 Tw T* [(Childr)-23.9(en )0.5(and )0.5(A)15(dul)56.1(ts. )]TJ /T1_2 1 Tf 8.391 0 Td [(R)22(ussian )0.6(Jour)-14(nal )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 7.511 0 Td [(Gastroenterology, )0.7(Hepatology, )]TJ 0 Tw -15.903 -1.25 Td [(Colop)46(roctology.)]TJ /T1_1 1 Tf 0.164 Tw [( 2021;31$2$:65\22691. $In Russ.$ d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-)Tj T* (4376-2021-31-2-65-91)Tj 0 0 0 1 k /GS1 gs 0.326 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Q)-16(uigle)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(EM. )0.6(Gut )0.5(micr)-32(obio)17(t)15(a, )0.5(infl)-15.9(amma)15(t)-32(ion )0.5(and )0.5(sym)10(pt)17(oma)15(t)-32(ic )]TJ -0.029 Tw -1.796 -1.25 Td [(di)-16(ver)-21.9(t)-32(icul)-16(ar disease. New insights int)17(o an)]TJ /Span<>> BDC ( )Tj EMC [(old and neglec)-16(ted disor)-24(der. )]TJ /T1_2 1 Tf 0.023 Tw T* [(J Gastrointestin Liv)13.1(er Dis)]TJ /T1_1 1 Tf (. 2010 Jun;19$2$:127\2269. PMID: 20593043.)Tj -0.011 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ak)10(ehir)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(H, Hir)-32(oshi)]TJ /Span<>> BDC ( )Tj EMC [(N. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Mul)56(t)-32(if)16(a)-17(ce)-11.9(ted Ef)-56(fec)-16(ts of)]TJ /Span<>> BDC ( )Tj EMC [(Gut Micr)-31.9(obio)17(t)15(a )]TJ 0.202 Tw -1.796 -1.25 Td [(on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Immune Sy)-13(stem of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he Intest)-32(inal Mucosa. )]TJ /T1_2 1 Tf 0 Tw (Immuno)Tj /T1_1 1 Tf 0.202 Tw (. 2021, )Tj 0.023 Tw T* (1$4$, 583-594.)Tj 0.14 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-32(v)-15(alho)]TJ /Span<>> BDC ( )Tj EMC [(AL, F)10(onseca)]TJ /Span<>> BDC ( )Tj EMC [(S, Miquel-Cl)30.1(op\351s)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Bioengineer)-36.9(ing )]TJ 0.196 Tw -1.796 -1.25 Td [(commensal ba)-17(c)-16(ter)-37(ia-der)-36.9(i)-16(ved outer membr)-33(ane vesicles for del)-31(i)-16(ver)-23.9(y )]TJ 0.194 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(biol)30(o)-15.9(gics t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he gastr)-32(ointest)-32(inal and r)-23.9(espir)-33(a)15(t)17(or)-24(y tr)-33(a)-17(c)-16(t. )]TJ /T1_2 1 Tf 0 Tw [(Jour)-13.9(nal )]TJ 0.104 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Extracellular V)33(esicles.)]TJ /T1_1 1 Tf [( 2019;8$1$:1632100. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/2001307)Tj T* (8.2019.1632100)Tj 0 0 0 1 k /GS1 gs 0.059 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Miy)22(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(J, Mizukur)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(T, P)40.1(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(SB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(gut micr)-32(obial me)-12(t)15(abo)]TJ 0 Tw (-)Tj 0.167 Tw -1.796 -1.25 Td [(l)-31(i)-24(te of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(inoleic a)-17.1(c)-23.9(id, 10-hydr)-32(o)14(xy-c)-23.9(is-12-o)-16(c)-16(t)15(adecenoic a)-17(c)-24(id, amel)-31(io)]TJ 0 Tw (-)Tj 0.203 Tw T* [(r)-33(a)15(tes intest)-32(inal epi)-24(t)-12.9(hel)-31(ial bar)-24(r)-37(ier im)10(p)32(air)-16(ment p)32(ar)-22(t)-32(iall)35(y v)-16(ia GPR40-)]TJ 0.007 Tc 0.349 Tw T* [(MEK-ERK p)32.3(a)15.3(t)-12.7(hw)-11.7(a)15.3(y. )]TJ /T1_2 1 Tf (J Biol Chem)Tj /T1_1 1 Tf [(. 2015 Jan 30;290$5$:2902\22618.)7( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.857 0 Td (10.1074/jbc.M114.610733)Tj 0 0 0 1 k /GS1 gs 0.033 Tw [( Epub )0.5(2014 Dec 10. )0.5(PMID: )0.5(25505251; )]TJ 0.023 Tw -1.857 -1.25 Td (PMCID: PMC4317025.)Tj 0.105 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(ol)-31(igne)]TJ /Span<>> BDC ( )Tj EMC [(B, Nut)-30(ten)]TJ /Span<>> BDC ( )Tj EMC [(S, G)20(r)-33(ange)-12(t)-29.9(te)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cor)-23.9(r)-24(el)-16(a)15(t)-32(ion be)-12(t)-32(ween )0.5(in )]TJ 0.018 Tw -1.796 -1.25 Td [(v)-16(i)-24(tr)-31.9(o and in v)-16(i)-15.9(vo immunomodul)-15.9(a)15(t)17(or)-24(y p)25(r)-32(oper)-22(t)-32(ies of)]TJ /Span<>> BDC ( )Tj EMC [(l)-15.9(a)-17(c)-16(t)-32(ic a)-17(c)-23.9(id ba)-17(c)-16(te)]TJ 0 Tw (-)Tj T* [(r)-37(ia. )]TJ /T1_2 1 Tf 0.031 Tw 1.654 0 Td [(W)29(orld J Gastroenterol.)]TJ /T1_1 1 Tf [( 2007 Jan 14;13$2$:236\22643. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/)Tj -1.654 -1.25 Td (wjg.v13.i2.236)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 17226902; PMCID: PMC4065951.)Tj 0.05 Tw T* (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Fl)30(o)-16(ch)]TJ /Span<>> BDC ( )Tj EMC (MH. A)Tj /Span<>> BDC ( )Tj EMC [(hypo)17(t)-12.9(hesis: is di)-16(ver)-22(t)-31.9(icul)-31(i)-24(t)-32(is a)]TJ /Span<>> BDC ( )Tj EMC [(t)-10(ype of)]TJ /Span<>> BDC ( )Tj EMC [(infl)-15.9(amma)15(t)17(or)-24(y )]TJ 0.17 Tw -1.796 -1.25 Td [(bo)-14(wel )0.5(disease? )]TJ /T1_2 1 Tf 6.555 0 Td [(J )0.5(Clin )0.5(Gastroenterol.)]TJ /T1_1 1 Tf [( )0.5(2006 )0.5(A)10(ug;40 )0.5(Suppl )0.5(3:S121\2265. )]TJ 0 Tw -6.555 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/01.mcg.0000225502.29498.ba)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 16885694.)Tj 0.192 Tw -1.847 -1.25 Td (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(er)-33(an)]TJ /Span<>> BDC ( )Tj EMC 2.702 0 Td [(L, )0.6(Camuesco)]TJ /Span<>> BDC ( )Tj EMC 5.44 0 Td [(D, )0.5(Comal)-15.9(ad)42(a)]TJ /Span<>> BDC ( )Tj EMC 5.4 0 Td [(M, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.532 0 Td [(al. )0.6(P)35(r)-24(event)15(a)15(t)-32(i)-16(ve )0.6(ef)-56(fec)-15.9(ts )]TJ 0.142 Tw -17.87 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(obio)17(t)-32(ic, L)-32(a)-17(c)-16(t)17(oba)-17(c)-24(ill)35(us sal)-31(i)-16(v)-15(ar)-37(ius ssp. sal)-31(i)-16(v)-14.9(ar)-37(ius, in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (TNBS )Tj 0.027 Tw T* (model of)Tj /Span<>> BDC ( )Tj EMC [(r)-33(a)15(t col)-31(i)-24(t)-31.9(is. )]TJ /T1_2 1 Tf [(W)29(orld J Gastroenterol.)]TJ /T1_1 1 Tf ( 2005 Sep 7;11$33$:5185\226)Tj 0.014 Tc 0.498 Tw T* [(92)0.5(. d)-15.5(oi:)]TJ /Span<>> BDC 3.727 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.014 Tw [(1)0.5(0.3)0.5(748/w)0.5(jg.)0.5(v11)0.5(.i33)0.5(.51)0.5(85)]TJ 0 0 0 1 k /GS1 gs 0.498 Tw [( PMID)0.5(: 1612)0.5(7750;)0.5( P)0.5(MCID)0.5(:)14( )]TJ 0 Tc 0 Tw -3.727 -1.25 Td (PMC4320393.)Tj -0.003 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Suez)Tj /Span<>> BDC ( )Tj EMC [(J, Zmor)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(N, Z)-16(ilber)-16(man-S)-23.9(chapir)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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[(Gastr)-32(oenter)-31.9(ol)30(o)-16(gists and Hep)32(a)15(t)17(ol)30(o)-16(gists. )]TJ /T1_1 1 Tf 0 Tw [(Exper)-37(imental )]TJ 0.023 Tw T* (and Clinical Gastroenterology)Tj /T1_0 1 Tf (. 2023;$2$:33\22669. $In Russ.$)Tj 0.021 Tc 0.767 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.36 0 Td [(\025\035\017\027\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\007\ \026\006\017\017. \212\017\r\036\030\021\017\022\031\035\016\030\027\026\ \016 \002\024\035\036\027\034)21( )]TJ 0 Tc 0.14 Tw -1.36 -1.25 Td (25.06.2021. \211\021\r\036\030\032\007\036\027\t \204\017\027\007\030\026\ \r\024\n)Tj /Span<>> BDC ( )Tj EMC [(\217\205. / Cl)-30.9(inical r)-23.9(ecommend)42(a)]TJ 0 Tw (-)Tj 0.199 Tw T* [(t)-32(ions. Di)-15.9(ver)-22(t)-32(icul)-15.9(ar disease 06/25/2021. )0.5(App)25(r)-32(oved b)12(y t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 24.369 0 Td [(Ministr)-23.9(y )]TJ 0.023 Tw -24.369 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Heal)56(t)-12.9(h of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Russian F)10(eder)-33(a)15(t)-32(ion. $in Russ.$.)]TJ 0.058 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Emile)Tj /Span<>> BDC ( )Tj EMC [(SH, Elfek)-16(i)]TJ /Span<>> BDC ( )Tj EMC (H, Sakr)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(a)-17(cute uncom)10(pl)-30.9(i)]TJ 0 Tw (-)Tj 0.093 Tw -1.296 -1.25 Td [(ca)15(ted di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is wi)-24(t)-12.9(hout ant)-32(ibio)17(t)-32(ics: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-31.9(ic r)-24(ev)-16(iew, me)-12(t)15(a-)]TJ 0.01 Tw T* [(anal)35(y)-13(sis, and me)-12(t)15(a-r)-23.9(egr)-24(ession of)]TJ /Span<>> BDC ( )Tj EMC [(p)24.9(r)-23.9(edic)-16(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment f)16(ail)35(ur)-24(e. )]TJ /T1_1 1 Tf 0 Tw [(T)54(ech )]TJ 0.005 Tc -0.005 Tw T* [(Colop)45.6(roctol)]TJ /T1_0 1 Tf 0.35 Tw [(. 2018 Jul;22$7$:499\226509. d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.1007/s10151-018-)Tj 0 Tc 0 Tw T* (1817-y)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2018 Jul 6. PMID: 29980885.)Tj 0.232 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Sar)-22(tell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(M, T)39.9(asc)-23.9(ini)]TJ /Span<>> BDC ( )Tj EMC [(C, Co)-16(ccol)-31(ini)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(intr)-33(a-)]TJ 0.007 Tc 0.349 Tw -1.296 -1.25 Td [(abd)-15.7(ominal infec)-15.6(t)-31.7(ions: r)-23.6(ecommend)42.4(a)15.3(t)-31.6(ions b)12.3(y t)-12.7(he)]TJ /Span<>> BDC ( )Tj EMC [(It)15.3(al)-30.6(ian counc)-23.6(il)7( )]TJ 0 Tc 0.315 Tw T* [(for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(opt)-32(imiza)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(imicr)-31.9(obial use. )]TJ /T1_1 1 Tf [(W)28.9(orld J Emerg Surg)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2024;19:23. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-024-00551-w)Tj 0 0 0 1 k /GS1 gs 0.032 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(De S)-16(imone)]TJ /Span<>> BDC ( )Tj EMC [(B, Co)-16(ccol)-31(ini)]TJ /Span<>> BDC ( )Tj EMC [(F, Ca)15(tena)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Benef)-28(i)-24(ts of)]TJ /Span<>> BDC ( )Tj EMC (WSES guide)Tj 0 Tw (-)Tj 0.003 Tw -1.296 -1.25 Td [(l)-31(ines appl)-31(ica)15(t)-32(ion for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(intr)-32.9(a-abd)-16(ominal infec)-16(t)-32(ions. )]TJ /T1_1 1 Tf 0.023 Tw T* [(W)29(orld J Emerg Surg.)]TJ /T1_0 1 Tf [( 2015;10:18. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/s13017-015-0013-x)Tj 0 0 0 1 k /GS1 gs 0.288 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(ill)-31(iams)]TJ /Span<>> BDC ( )Tj EMC [(S, Bjar)-14.9(nason)]TJ /Span<>> BDC ( )Tj EMC [(I, Ha)15(yee)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Di)-16(ver)-21.9(t)-32(icul)-16(ar disease: )]TJ -0.043 Tw -1.296 -1.25 Td [(upd)42(a)15(te on p)32(a)15(t)-13(hophy)-13(siol)30.1(o)-16(g)16(y, cl)-16(assif)-28(ica)15(t)-32(ion and mana)-17(gement. )]TJ /T1_1 1 Tf 0 Tw [(F)26.9(rontline )]TJ T* (Gastroenterology. )Tj /T1_0 1 Tf 7.194 0 Td (2024;15:50\22658.)Tj 0.153 Tw -7.194 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Nikolenko)Tj /Span<>> BDC ( )Tj EMC [(VN, Oganesy)22(an)]TJ /Span<>> BDC ( )Tj EMC [(MV, Sankov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(MV, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(ane)-12(t)-13(h cells: )]TJ 0.011 Tc 0.409 Tw -1.796 -1.25 Td [(Maint)15(aining d)17(ynamic micr)-32(obiome-host homeost)14.9(asis, p)25(r)-32(o)17(tec)-16(t)-32(ing)11( )]TJ 0 Tc 0.023 Tw T* [(a)-17(gainst infl)-15.9(amma)15(t)-32(ion and cancer. )]TJ /T1_1 1 Tf 0 Tw (Bioessays)Tj /T1_0 1 Tf 0.023 Tw (. 2021, 43, 2000180)Tj 0.066 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)25(an R)11.1(ossen)]TJ /Span<>> BDC ( )Tj EMC [(TM, Ooijev)-15(aar)]TJ /Span<>> BDC ( )Tj EMC [(RE, K)25(uyvenhoven)]TJ /Span<>> BDC ( )Tj EMC [(JP, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(obio)17(t)15(a )]TJ 0.116 Tw -1.796 -1.25 Td [(com)10(posi)-24(t)-32(ion )0.5(and mucosal immuni)-23.9(t)-10(y in p)32(a)15(t)-32(ients )0.5(wi)-24(t)-13(h asym)10(pt)17.1(oma)15(t)-32(ic )]TJ 0.023 Tw T* [(di)-16(ver)-21.9(t)-32(icul)30(osis and contr)-31.9(ols. )]TJ /T1_1 1 Tf (PLoS One. )Tj /T1_0 1 Tf 0 Tw (2021;16:e0256657.)Tj 0.249 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ale)-18(x)-10.9(ander)-10(sson)]TJ /Span<>> BDC ( )Tj EMC [(B)13(T, Huger)-21.9(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(L)50(W, Hedin)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Di)-16(ver)-21.9(t)-32(icul)30(osis )]TJ 0.194 Tw -1.796 -1.25 Td [(is no)17(t asso)-16(c)-24(ia)15(ted wi)-23.9(t)-13(h al)56.1(ter)-24(ed gut micr)-32(obio)17(t)15(a nor is i)-24(t p)25(r)-24(edic)-16(t)-31.9(i)-16(ve )]TJ -0.034 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(futur)-23.9(e di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-15.9(a)15(t)-32(ion-based col)30(onoscopy )0.5(stud)17(y. )]TJ /T1_1 1 Tf 0 Tw (Scand )Tj 0.023 Tw T* (J Gastroenterol.)Tj /T1_0 1 Tf [( 2023;1-8. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/00365521.2023.2194010)Tj 0 0 0 1 k /GS1 gs -0.021 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ser)-24(ek)]TJ /Span<>> BDC ( )Tj EMC [(P, Olek)-10(sy-W)12.1(a)10(wr)-24(zyniak)]TJ /Span<>> BDC ( )Tj EMC [(M. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Ef)-56(fec)-15.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(Ba)-16.9(c)-16(ter)-37(ial Infec)-16(t)-32(ions, )]TJ 0.055 Tw -1.796 -1.25 Td [(P)35(r)-32(obio)17(t)-32(ics and Z)25(onul)-31(in on Intest)-32(inal Bar)-23.9(r)-37(ier Integr)-37(i)-23.9(t)-10(y. )]TJ /T1_1 1 Tf (Int J Mol Sci.)Tj /T1_0 1 Tf 0 Tw ( )Tj T* (2021;222:1359.)Tj 0.109 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bar)-24(bar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(G, S)-24(caiol)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(E, Bar)-23.9(bar)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(MR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut micr)-32(obio)17(t)15(a, me)-12(t)15(ab)]TJ 0 Tw (-)Tj 0.006 Tc 0.35 Tw -1.796 -1.25 Td [(ol)29.8(ome and immune signa)14.8(tur)-24.2(es in p)31.8(a)14.8(t)-32.2(ients wi)-24.2(t)-13.2(h uncom)9.8(pl)-31.2(ica)14.8(ted)6( )]TJ 0 Tc 0.063 Tw T* [(di)-16(ver)-21.9(t)-32(icul)-16(ar disease. )]TJ /T1_1 1 Tf 0 Tw (Gut)Tj /T1_0 1 Tf 0.063 Tw [(. 2017 Jul;66$7$:1252\2261261. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/)Tj T* (gutjnl-2016-312377)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2016 Sep 12. PMID: 27618836.)Tj 0.01 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Daniels)Tj /Span<>> BDC ( )Tj EMC (L, Budding)Tj /Span<>> BDC ( )Tj EMC [(AE, de K)25(or)-22(te)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(ecal micr)-32(obiome anal)35(y)]TJ 0 Tw 25.49 0 Td (-)Tj 0.098 Tw -27.286 -1.25 Td (sis as a)Tj /Span<>> BDC ( )Tj EMC [(dia)-17(gnost)-32(ic test for di)-16(ver)-21.9(t)-32(icul)-31(i)-24(t)-31.9(is. )]TJ /T1_1 1 Tf (Eur J Clin Microbiol Infect )Tj 0 Tw T* (Dis. )Tj /T1_0 1 Tf 0.305 Tw 2.004 0 Td [(2014 )0.5(N)-14(ov;33$11$:1927\22636. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 13.949 0 Td (10.1007/s10096-014-2162-3)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw -15.954 -1.25 Td (Epub 2014 Jun 4. PMID: 24894339.)Tj 0.001 Tc 0.35 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.801 0 Td (\214\036\r\004\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC [(\225.\200. \215\030\024\021\017\r\024\030\036\006\017\007\017\r\027\024\036\ \035\036\004\036\027\017\036 \007\017\r\036\030\021\017\022\031\035\017\ \021\026)1( )]TJ 0.009 Tc 0.349 Tw -1.801 -1.25 Td (\021\024\035\f\021\024\005 \022\017\001\022\017. )Tj /T1_1 1 Tf (\204\021\024\f\016\033\022\b\016\020\035\037\027\007\020\037\030 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\n\016\024\021\037\030 \013\037\024\035\033\034\220\020\ )Tj 0 Tc 0 Tw (-)Tj T* (\035\016\033\034\027\034\013\022\030.)Tj /T1_0 1 Tf 0.291 Tw [( 2014;107$7$:45\22654. / L)35(evchenko)]TJ /Span<>> BDC ( )Tj EMC [(S.V. Ant)-31.9(i-r)-24(ecur)-23.9(r)-24(ent )]TJ 0.06 Tw T* [(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.417 0 Td [(col)30(on )0.5(di)-16(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 8.372 0 Td [(Ek)-23(sper)-36.9(imental\245naya )0.5(i )0.5(Klinichesk)11(aya )]TJ 0 Tw -13.789 -1.25 Td (Gastroenterologiya.)Tj /T1_0 1 Tf 0.023 Tw ( 2014;107$7$:45\22654.)Tj 0.021 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)20(v)-15(asnovsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC [(C.L, L)35(eong)]TJ /Span<>> BDC ( )Tj EMC [(L.X, )0.5(Cho)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(J.M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical and sym)10(pt)17.1(om )]TJ 0.238 Tw -1.796 -1.25 Td [(scor)-24(es ar)-24(e signif)-27.9(icantl)35(y cor)-24(r)-24(el)-16(a)15(ted wi)-23.9(t)-13(h fecal micr)-31.9(obio)17(t)15(a fea)15(tur)-24(es )]TJ 0.207 Tw T* [(in p)32(a)15(t)-32(ients wi)-24(t)-13(h sym)10(pt)17(oma)15(t)-31.9(ic uncom)10(pl)-31(ica)15(ted di)-16(ver)-22(t)-32(icul)-15.9(ar disease: )]TJ 0.066 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(pil)30(o)17(t stud)17(y. )]TJ /T1_1 1 Tf (Eur J Gastroenterol Hepatol)Tj /T1_0 1 Tf (. 2018 Jan;30$1$:107\226112. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/MEG.0000000000000995)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 29084074.)Tj -0.007 Tw -1.847 -1.25 Td (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)60(ur)-10(si)]TJ /Span<>> BDC ( )Tj EMC [(A, Mastr)-31.9(omar)-37(ino)]TJ /Span<>> BDC ( )Tj EMC (P, Capobianco)Tj /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Assess)26(ment of)]TJ /Span<>> BDC ( )Tj EMC [(F)10(ecal )]TJ 0.253 Tw -1.796 -1.25 Td [(Micr)-32(obio)17(t)15.1(a )0.5(and F)10(ecal )0.5(Me)-12(t)15(abol)30(ome )0.5(in )0.5(Sym)10(pt)17.1(oma)15(t)-32(ic )0.5(U)13(ncom)10(pl)-31(ica)15(ted )]TJ 0.106 Tw T* [(Di)-16(ver)-21.9(t)-32(icul)-16(ar Disease of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he Col)30(on. )]TJ /T1_1 1 Tf (J Clin Gastroenterol. )Tj /T1_0 1 Tf [(2016 O)-16(c)-16(t;50 )]TJ 0.013 Tc 0.492 Tw T* [(Suppl 1:S9\226S12. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw (10.1097/MCG.0000000000000626)Tj 0 0 0 1 k /GS1 gs 0.492 Tw [( PMID:)13( )]TJ 0 Tc 0 Tw T* (27622378.)Tj 0.262 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(inninge)]TJ /Span<>> BDC ( )Tj EMC [(C, R)11(o)16.9(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC [(B, Er)-30(l)-16(anson-Alber)-21.9(tsson)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-14(bund)42(ance )]TJ 0.338 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.386 0 Td [(Enter)-31.9(oba)-17(c)-16(ter)-37(ia)-17(ceae )0.5(in )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 11.725 0 Td [(col)30(on )0.5(mucosa )0.5(in )0.5(di)-16(ver)-22(t)-32(icul)-15.9(ar )0.5(dis)]TJ 0 Tw (-)Tj -13.111 -1.25 Td (ease. )Tj /T1_1 1 Tf 0.235 Tw 2.55 0 Td [(W)29(orld J Gastrointest P)18(athoph)12(ysiol)]TJ /T1_0 1 Tf [(. 2018 F)10(eb 15;9$1$:18\22627. )]TJ 0 Tw -2.55 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4291/wjgp.v9.i1.18)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 29487763; PMCID: PMC5823699.)Tj 0.006 Tw -1.847 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mj)Tj /Span<>> BDC ( )Tj EMC [(O, T)60(ur)-15(ner)]TJ /Span<>> BDC ( )Tj EMC [(GA, F)10(r)-37(izelle)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dist)-32(inc)-16(t changes in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic )]TJ -0.002 Tw -1.796 -1.25 Td [(micr)-32(obiome )0.6(asso)-16(c)-24(ia)15(ted )0.6(wi)-24(t)-13(h )0.6(a)-17(cute )0.5(di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is. )]TJ /T1_1 1 Tf 19.84 0 Td [(Colorectal )0.6(Dis.)]TJ /T1_0 1 Tf [( )0.5(2022 )]TJ -0.02 Tw 9.215 81.25 Td [(Dec;24$12$:1591\2261601. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16271)Tj 0 0 0 1 k /GS1 gs -0.02 Tw [( Epub 2022 A)10(ug 11. )]TJ 0.023 Tw T* (PMID: 35950499; PMCID: PMC10087140.)Tj 0.223 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Humes)Tj /Span<>> BDC ( )Tj EMC [(DJ, S)-16(im)10(pson)]TJ /Span<>> BDC ( )Tj EMC [(J, Smi)-23.9(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)-15(iscer)-33(al hyper)-9.9(sensi)-24(t)-32(i)-16(v)]TJ 0 Tw 25.49 0 Td (-)Tj 0.158 Tw -27.286 -1.25 Td [(i)-24(t)-10(y in sym)10(pt)17(oma)15(t)-32(ic di)-16(ver)-22(t)-32(icul)-15.9(ar disease and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(neur)-32(opep)]TJ 0 Tw (-)Tj 0.197 Tw T* [(t)-32(ides and l)30(o)-14(w gr)-33(ade infl)-16(amma)15(t)-32(ion. )]TJ /T1_1 1 Tf [(N)18(eurog)12(astroenterol Mo)13(til.)]TJ /T1_0 1 Tf ( 2012 )Tj 0.112 Tw T* [(Ap)25(r;24$4$:318\226e163. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/j.1365-2982.2011.01863.x)Tj 0 0 0 1 k /GS1 gs 0.112 Tw ( Epub )Tj 0.023 Tw T* (2012 Jan 25. PMID: 22276853.)Tj -0.018 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chief)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(KM, Kl)-31(ine)]TJ /Span<>> BDC ( )Tj EMC [(BP, Har)-24(r)-37(is)]TJ /Span<>> BDC ( )Tj EMC [(LR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. $2018$ A)Tj /Span<>> BDC ( )Tj EMC [(dif)-55.9(fer)-24(ent)-32(ial host )]TJ 0.131 Tw -1.796 -1.25 Td [(r)-24(esponse t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(v)-16(ir)-33(al infec)-15.9(t)-32(ion def)-28(ines a)]TJ /Span<>> BDC ( )Tj EMC [(subse)-11.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(ear)-30(l)-31(ier-onse)-11.9(t di)-16(ver)]TJ 0 Tw 27.286 0 Td (-)Tj 0.023 Tw -27.286 -1.25 Td [(t)-32(icul)-30.9(i)-24(t)-32(is p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf [(J Gastrointestin Liv)13(er Dis.)]TJ /T1_0 1 Tf ( 27$3$:249\226255.)Tj 0.08 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(car)-24(pigna)15.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(C, Bar)-24(bar)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(G, L)-32(anas)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(on)]TJ 0 Tw (-)Tj 0.285 Tw -1.796 -1.25 Td [(ic di)-16(ver)-22(t)-32(icul)-15.9(ar disease in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(hir)-24(d millennium: Highl)-31(ights fr)-32(om )]TJ 0.27 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(sym)10.1(posium held dur)-37(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(U)13(ni)-24(ted Eur)-32(opean Gastr)-31.9(oenter)-32(ol)30(o)-16(g)16(y )]TJ 0.118 Tw T* [(W)22(eek 2017. )]TJ /T1_1 1 Tf (Therap Adv Gastroenterol)Tj /T1_0 1 Tf (. 2018;11:1756284818771305. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/1756284818771305)Tj 0 0 0 1 k /GS1 gs -0.018 Tw -1.847 -1.25 Td (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chief)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(KM, Kl)-31(ine)]TJ /Span<>> BDC ( )Tj EMC [(BP, Har)-24(r)-37(is)]TJ /Span<>> BDC ( )Tj EMC [(LR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. $2018$ A)Tj /Span<>> BDC ( )Tj EMC [(dif)-55.9(fer)-24(ent)-32(ial host )]TJ 0.131 Tw -1.796 -1.25 Td [(r)-24(esponse t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(v)-16(ir)-33(al infec)-15.9(t)-32(ion def)-28(ines a)]TJ /Span<>> BDC ( )Tj EMC [(subse)-11.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(ear)-30(l)-31(ier-onse)-11.9(t di)-16(ver)]TJ 0 Tw 27.286 0 Td (-)Tj 0.023 Tw -27.286 -1.25 Td [(t)-32(icul)-30.9(i)-24(t)-32(is p)32(a)15(t)-32(ients. )]TJ /T1_1 1 Tf [(J Gastrointestin Liv)13(er Dis.)]TJ /T1_0 1 Tf ( 27$3$:249\226255.)Tj -0.019 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jones)Tj /Span<>> BDC ( )Tj EMC 2.539 0 Td [(RB, )0.5(F)10(od)-16(or)]TJ /Span<>> BDC ( )Tj EMC 3.932 0 Td [(AA, )0.5(P)30(eer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC 3.919 0 Td [(AF, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.423 0 Td [(al. )0.5(An)]TJ /Span<>> BDC ( )Tj EMC 2.518 0 Td [(A)-14(ber)-23.9(r)-33(ant )0.5(Micr)-32(obio)17(t)15(a )0.5(is )0.5(no)17(t )]TJ 0.109 Tw -17.127 -1.25 Td [(S)15(tr)-32(ongl)35(y Asso)-16(c)-24(ia)15.1(ted wi)-23.9(t)-13(h Inc)-24(ident)15(al Col)30(onic Di)-16(ver)-22(t)-32(icul)30.1(osis. )]TJ /T1_1 1 Tf [(Sci R)21(ep. )]TJ /T1_0 1 Tf 0.257 Tw T* [(2018 Mar 21;8$1$:4951. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1038/s41598-018-23023-z)Tj 0 0 0 1 k /GS1 gs 0.257 Tw ( PMID: )Tj 0.023 Tw T* (29563543; PMCID: PMC5862835.)Tj 0.006 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mj)Tj /Span<>> BDC ( )Tj EMC [(O, T)60(ur)-15(ner)]TJ /Span<>> BDC ( )Tj EMC [(GA, F)10(r)-37(izelle)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dist)-32(inc)-15.9(t changes in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(col)30(onic )]TJ -0.002 Tw -1.796 -1.25 Td [(micr)-32(obiome )0.6(asso)-16(c)-24(ia)15(ted )0.6(wi)-24(t)-13(h )0.6(a)-17(cute )0.5(di)-16(ver)-21.9(t)-32(icul)-31(i)-23.9(t)-32(is. )]TJ /T1_1 1 Tf 19.84 0 Td [(Colorectal )0.6(Dis.)]TJ /T1_0 1 Tf [( )0.5(2022 )]TJ -0.02 Tw -19.84 -1.25 Td [(Dec;24$12$:1591\2261601. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16271)Tj 0 0 0 1 k /GS1 gs -0.02 Tw [( Epub 2022 A)10(ug 11. )]TJ 0.023 Tw T* (PMID: 35950499; PMCID: PMC10087140.)Tj 0.017 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ope)-12(tuso)]TJ /Span<>> BDC ( )Tj EMC [(LR, P)30(e)-12(t)-32(i)-24(t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(V, G)20(r)-33(a)-24(ziani)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gut Micr)-31.9(obio)17(t)15(a in Heal)56.1(t)-13(h, )]TJ 0.23 Tw -1.796 -1.25 Td [(Di)-16(ver)-21.9(t)-32(icul)-16(ar Disease, Ir)-23.9(r)-37(i)-24(t)15(able Bo)-13.9(wel Syndr)-32(ome, and Infl)-16(amma)15(t)17(or)-23.9(y )]TJ 0.01 Tc 0.365 Tw T* [(Bo)-13.7(wel Diseases: T)35.2(ime for Micr)-31.7(obial Mar)-23.7(k)10.2(er of)]TJ /Span<>> BDC ( )Tj EMC [(Gastr)-31.8(ointest)-31.7(inal)10( )]TJ 0 Tc 0 Tw T* [(Disor)-23.9(der)-10(s. )]TJ /T1_1 1 Tf -0.013 Tw 4.26 0 Td (Dig Dis)Tj /T1_0 1 Tf [(. 2018;36$1$:56\22665. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000477205)Tj 0 0 0 1 k /GS1 gs -0.013 Tw ( Epub )Tj 0.023 Tw -4.26 -1.25 Td (2017 Jul 7. PMID: 28683448.)Tj 0.042 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-24(chief)-56(fer)]TJ /Span<>> BDC ( )Tj EMC [(KM, Sabe)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(K, W)14(r)-37(ight)]TJ /Span<>> BDC ( )Tj EMC [(JR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)46.9(he)]TJ /Span<>> BDC ( )Tj EMC [(Micr)-32(obial E)15(cosy)-13(stem )]TJ 0.2 Tw -1.796 -1.25 Td [(Dist)-32(inguishes Chr)-32(onicall)35(y Diseased T)35(issue fr)-32(om A)15(d)17(ja)-17(cent T)35(issue in )]TJ 0.106 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(S)-16(igmoid Col)30(on of)]TJ /Span<>> BDC ( )Tj EMC [(Chr)-32(onic, R)13(ecur)-24(r)-24(ent Di)-15.9(ver)-22(t)-32(icul)-30.9(i)-24(t)-32(is P)40(a)15(t)-32(ients. )]TJ /T1_1 1 Tf 0 Tw (Sci )Tj 0.001 Tc -0.001 Tw T* [(R)21.5(ep)0.5(.)]TJ /T1_0 1 Tf 0.349 Tw 1.716 0 Td [( 20)0.5(1)0.5(7 A)10.5(u)0.5(g 1)0.5(6;)0.5(7)0.5($1)0.5($)0.5(:)0.5(84)0.5(6)0.5(7.)0.5( d)-15.6(o)0.5(i)0.5(:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.001 Tw [(1)0.5(0)0.5(.1)0.5(0)0.5(38)0.5(/)0.5(s4)0.5(1)0.5(59)0.5(8-)0.5(0)0.5(17)0.5(-)0.5(06)0.5(7)0.5(87)0.5(-8)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 25.922 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 28814777; PMCID: PMC5559482.)Tj 0.049 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)-16(i)-24(t)17.1(omer)-10(sk)-32(y)]TJ /Span<>> BDC ( )Tj EMC 4.705 0 Td [(NL, )0.5(A)30(tk)-16(inson)]TJ /Span<>> BDC ( )Tj EMC 5.326 0 Td [(BJ, )0.5(F)10(r)-33(ankl)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(S)-10(W, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 7.782 0 Td [(al. )0.5(Char)-33(a)-17(c)-16(ter)-36.9(iza)15(t)-32(ion )]TJ 0.151 Tw -19.609 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(adher)-24(ent ba)-17(c)-16(ter)-32(oid)42(ales fr)-32(om intest)-32(inal biopsies of)]TJ /Span<>> BDC ( )Tj EMC [(childr)-23.9(en and )]TJ 0.294 Tw T* [(young adul)56(ts wi)-24(t)-13(h infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease. PL)35(oS One. 2013 )]TJ 0.009 Tc 0.35 Tw T* [(Jun )0.5(11;8$6$:e63686. d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw [(10.1371/jour)-15.1(nal.pone.0063686)]TJ 0 0 0 1 k /GS1 gs 0.35 Tw [( )0.5(PMID:)9( )]TJ 0 Tc 0.023 Tw T* (23776434; PMCID: PMC3679120)Tj 0.04 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)30(e)-12(ter)-9.9(son)]TJ /Span<>> BDC ( )Tj EMC [(D)20(A, McNul)56(t)-9.9(y)]TJ /Span<>> BDC ( )Tj EMC [(NP, Gur)-22(uge)]TJ /Span<>> BDC ( )Tj EMC [(JL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. IgA r)-24(esponse t)17(o)]TJ /Span<>> BDC ( )Tj EMC (sym)Tj 0 Tw (-)Tj 0.083 Tw -1.796 -1.25 Td [(bio)17(t)-32(ic )0.5(ba)-17(c)-16(ter)-36.9(ia as )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 8.285 0 Td [(media)15(t)17(or )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.011 0 Td [(gut )0.5(homeost)15(asis. )]TJ /T1_1 1 Tf 7.25 0 Td [(Cell )0.5(Host )0.5(Microbe.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.071 Tw -20.546 -1.25 Td [(2007 N)-14(ov 15;2$5$:328\22639. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.chom.2007.09.013)Tj 0 0 0 1 k /GS1 gs 0.071 Tw ( PMID: )Tj 0 Tw T* (18005754.)Tj 0.081 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tum)10(pf)]TJ /Span<>> BDC ( )Tj EMC (M, Cao)Tj /Span<>> BDC ( )Tj EMC [(W, Kl)-31(inge)]TJ /Span<>> BDC ( )Tj EMC [(U, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-24(eased distr)-36.9(ibut)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (col)Tj 0 Tw (-)Tj 0.029 Tw -1.796 -1.25 Td [(l)-16(a)-17(gen t)-10(ype III and r)-24(educed e)-18(xp)25(r)-23.9(ession of)]TJ /Span<>> BDC ( )Tj EMC [(ma)15.1(tr)-37(ix me)-12(t)15(all)30(op)25.1(r)-32(o)17(teinase 1 )]TJ -0.032 Tw T* [(in p)32(a)15(t)-32(ients wi)-24(t)-13(h di)-16(ver)-22(t)-32(icul)-16(ar disease. )]TJ /T1_1 1 Tf (Int J Color Dis.)Tj /T1_0 1 Tf ( 2001;16$5$:271\226)Tj 0 Tw T* (275)Tj 0.006 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(auppil)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(JH, K)-15.9(ar)-22(t)-30(tunen)]TJ /Span<>> BDC ( )Tj EMC [(T)25(J, Saar)-15(nio)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(hor)-22(t DN)13(A sequences )]TJ 0.17 Tw -1.796 -1.25 Td [(and )0.5(ba)-17(c)-16(ter)-37(ial )0.6(DN)13(A induce )0.6(esopha)-17(geal, )0.5(gastr)-37(ic, )0.5(and )0.5(col)30(or)-23.9(ec)-16(t)15(al )0.5(can)]TJ 0 Tw (-)Tj 0.192 Tw T* [(cer cell inv)-15(asion. )]TJ /T1_1 1 Tf 0 Tw (APMIS.)Tj /T1_0 1 Tf 0.192 Tw [( 2013 Jun;121$6$:511\22622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj T* (apm.12016)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2012 O)-16(c)-16(t 22. PMID: 23082743.)]TJ 0.145 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(osemar)]TJ /Span<>> BDC ( )Tj EMC [(A, Iv)-15(ar)-10(sson)]TJ /Span<>> BDC ( )Tj EMC [(ML, B\366r)-46(jesson)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Incr)-24(eased concen)]TJ 0 Tw (-)Tj 0.35 Tw -1.796 -1.25 Td [(tr)-33(a)15(t)-32(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.81 0 Td [(t)-32(issue-degr)-33(ading )0.6(ma)14.9(tr)-37(ix )0.5(me)-12(t)15(all)30(op)25(r)-32(o)16.9(teinases )0.5(and )0.5(t)-13(heir )]TJ 0.066 Tw -4.81 -1.25 Td [(inhibi)-24(t)17.1(or in com)10(pl)-31(ica)15(ted di)-16(ver)-21.9(t)-32(icul)-16(ar disease. )]TJ /T1_1 1 Tf (Scand J Gastroenterol.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.223 Tw T* [(2007 )0.5(F)10(eb;42$2$:215\22620. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 12.539 0 Td (10.1080/00365520600960104)Tj 0 0 0 1 k /GS1 gs 0.223 Tw [( )0.6(PMID: )]TJ 0 Tw -12.539 -1.25 Td (17327941.)Tj 0.294 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ulmer)Tj /Span<>> BDC ( )Tj EMC [(TF, R)11(osch)]TJ /Span<>> BDC ( )Tj EMC 7.369 0 Td [(R, M)-24(ossd)-16(or)-23.9(f)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(onic )0.5(w)-12(all changes )]TJ 0.001 Tc 0.349 Tw -9.165 -1.25 Td [(in p)32.3(a)15.3(t)-31.7(ients wi)-23.7(t)-12.7(h di)-15.7(ver)-21.7(t)-31.7(icul)-15.7(ar disease)]TJ /Span<>> BDC ( )Tj EMC [(\227 is t)-12.7(her)-23.7(e a)]TJ /Span<>> BDC ( )Tj EMC [(p)25.3(r)-23.7(edisposi)]TJ 0 Tc 0 Tw (-)Tj 0.333 Tw T* [(t)-32(ion for a)]TJ /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(ted cour)-9.9(se? )]TJ /T1_1 1 Tf (Int J Surg)Tj /T1_0 1 Tf (. 2014;12$5$:426\22631. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.796 0 Td (10.1016/j.ijsu.2014.03.014)Tj 0 0 0 1 k /GS1 gs -0.028 Tw ( Epub 2014 Mar 25. PMID: 24681094.)Tj 0.09 Tw -1.796 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mimur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Ba)15(teman)]TJ /Span<>> BDC ( )Tj EMC [(A)16(C, L)35.1(ee)]TJ /Span<>> BDC ( )Tj EMC [(RL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. U)13(p-r)-23.9(egul)-16(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(coll)-16(a)-17(gen )]TJ 0.154 Tw -1.796 -1.25 Td [(and t)-32(issue inhibi)-24(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(ma)15(tr)-37(ix me)-12(t)15(all)30.1(op)24.9(r)-31.9(o)16.9(teinase )0.5(in col)30(onic di)-16(ver)]TJ 0 Tw 27.286 0 Td (-)Tj 0.032 Tw -27.286 -1.25 Td [(t)-32(icul)-15.9(ar disease. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf ( 2004 Mar;47$3$:371\2268; discussion )Tj 0.023 Tw T* [(378-9. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10350-003-0050-5)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 14991500.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td 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Tf 0.024 Tw [( R)19.1(osebur)-37(ia hominis )]TJ /T1_1 1 Tf 0 Tw (\017)Tj /T1_2 1 Tf 0.024 Tw /Span<>> BDC ( )Tj EMC [(Akk)17(er)-13.9(mansia muciniph)]TJ 0 Tw (-)Tj 0 -1.218 TD (ila)Tj /T1_1 1 Tf -0.008 Tw ( \016\r\035\016\033\021\f\016 \027\036\024\021\255\036\n\035\036\n\024\005\ \004\026\f\021\034\033 \023\026\021\024\020\036\027\036\026 \007\017\r\ \036\030)Tj 0 Tw (-)Tj T* (\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\017.)Tj -0.014 Tw T* (\215\030\017 \024\f\035\024\032\027\036\027\027\024\n \021\036\004\036\027\ \017\017 \007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\ \024\035\036\027\017 )Tj 0.271 Tw T* (\024\021\n\036\004\026\036\021\f\016 \031\r\036\035\017\004\036\027\017\036\ \022\024\035\017\004\036\f\021\r\026 \r\f\036\b \021\017\023\024\r \022\ \017)Tj 0 Tw (-)Tj 0.023 Tw T* (\001\036\004\027\t\b \002\026\022\021\036\030\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 )Tj /T1_2 1 Tf 0 Tw [(Fir)-14(micutes)]TJ /T1_1 1 Tf 0.023 Tw ( \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024)Tj 0 Tw (-)Tj 0.199 Tw 0 -1.218 TD [(\n\026\021\017\004\036\f\022\017 )0.6(\027\036\024\f\035\024\032\027\036\027\027\024\005 )0.5(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024\035\036)]TJ 0 Tw (-)Tj 0 -1.218 TD (\027\017, )Tj /T1_2 1 Tf [(Pro)13(teobacter)-36.9(ia)]TJ /T1_1 1 Tf ( \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\b \235\024\030\n\026\b.)Tj -0.05 Tw T* (\215\024\035\031\004\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t \017\f\f\035\036\007\024\r\026\027\017\005 \023\024\007\004\036\030\022\ \017\r\026\033\021, )Tj -0.023 Tw T* (\004\021\024 \002\026\035\026\027\f \n\036\032\007\031 \f\017\n\002\017\024\ \021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\002\017\024\027\021\026\n\017 \017\020\030\026\036\021 \ )Tj 0.254 Tw T* (\r\026\032\027\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC 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\024\002\024\f\021\030\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.257 Tw T* [(\235\017\035\026\022\021\017\022\031 )0.6(\030\036\006\017\007\017\r\024\r. )0.5(\204\t )0.5(\027\026\007\036\036\n\f\016, )0.6(\004\021\024 )0.5(\017\031\004\036\027\017\036 )]TJ 0.367 Tw 23.244 49.93 Td (\007\026\027\027\024\020\024 \027\026\023\030\026\r\035\036\027\017\016 \ \023\030\017\r\036\007\036\021 \022)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\024\005 \021\026\022\021\017\022\036 )Tj 0.104 Tw T* (\r\036\007\036\027\017\016 \023\026\006\017\036\027\021\024\r, \024\b\r\026\ \021\t\r\026\033\013\036\005 \r\f\036 \r\036\027\034\016 \023\026\021\024\ )Tj 0 Tw (-)Tj T* (\020\036\027\036\026 \007\017\r\036\030\021\017\022\031\035\016\030\027\ \024\005 \002\024\035\036\027\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\226\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.399 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.3(\024)-4.4(\r)-8.8(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.007 Tc 0.406 Tw [( \213)-0.6(\013\037)-5.2(\f)-2.5(\034)2.6(\036)]TJ /Span<>> BDC 19.528 0 Td ( )Tj EMC [(\240)12.4(.\213)-9.3(.)0.8(,)-7( )]TJ 0 Tc 0 Tw -19.528 -1.218 Td [(\r)16.1(\037)4.8(\021)9.8(\034)3(\035)10.1(\021)12.8(\022)7.2(\020)]TJ /Span<>> BDC ( )Tj EMC [(\215)24.3(.)28.5(\215)24.3(.)7.8(, \002)27.6(\023)12.6(\036)-0.8(\034)5(\033\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\215)24.3(.)7.3(\213)-2.3(.)]TJ /T1_1 1 Tf 0.777 Tw T* [(\225)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_2 1 Tf [( \002)27.6(\023)12.6(\036)-0.8(\034)4.9(\033\034)9.7(\036)]TJ /Span<>> BDC ( )Tj EMC [(\215)24.3(.)7.3(\213)-2.3(.)7.8(, )]TJ -0.024 Tc 0.024 Tw T* [(\r)-7.9(\037)-19.2(\021)-14.2(\034)-21(\035)-13.9(\021)-11.3(\022)-16.8(\020)]TJ /Span<>> BDC 4.092 0 Td ( )Tj EMC [(\215.)4.5(\215.)]TJ /T1_1 1 Tf 0.018 Tc 1.741 Tw -4.092 -1.218 Td [(\225)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.1(\002)21.1(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_2 1 Tf 0 Tc 1.759 Tw 13.108 0 Td [( \002)27.6(\023)12.6(\036)-0.8(\034)4.9(\033\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\215)24.3(.)7.3(\213)-2.3(.)7.9(, )]TJ -0.024 Tc 0.024 Tw -13.108 -1.218 Td [(\r)-7.9(\037)-19.2(\021)-14.2(\034)-21(\035)-13.9(\021)-11.3(\022)-16.8(\020)]TJ /Span<>> BDC 4.092 0 Td ( )Tj EMC [(\215.)4.5(\215.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -4.092 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \002)27.6(\023)12.6(\036)-0.8(\034)4.9(\033\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\215)24.3(.)7.3(\213)-2.3(.)7.8(, \r)16.1(\037)4.9(\021)9.8(\034)3(\035)10.1(\021)12.7(\022)7.2(\020)]TJ /Span<>> BDC ( )Tj EMC [(\215)24.3(.)28.5(\215)24.3(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw [( \213)-3.6(\013)-3.4(\037)-8.2(\f)-5.5(\034\036)]TJ /Span<>> BDC 10.199 0 Td ( )Tj EMC [(\240)9.4(.)-2.7(\213)-12.2(.)-2.2(,)-10( \r)6.1(\037)-5.2(\021\034)-7(\035\021)2.7(\022)-2.8(\020)]TJ /Span<>> BDC 6.508 0 Td ( )Tj EMC [(\215)14.3(.)18.5(\215)14.4(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -16.707 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.172 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)2.8(ga)-0.8(p)-4.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(V)-5.5(i)7.9(k)-20.8(t)1.4(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)1.7(k)12.9(o)1.5(t)-6.8(k)-18.5(i)8.4(n)-6(, V)-5.5(i)5.9(a)-5(c)1.8(h)2(e)-18(s)9.3(l)3.3(a)-4.4(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)-2(v)7.6(o)1.4(r)2.4(o)-0.6(v)]TJ /T1_1 1 Tf -0.027 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-5.9(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 11.635 0 Td [(t)-16.7(h)-5.3(e )0.5(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf -0.008 Tc -0.019 Tw [( )0.5(S)7.8(u)-10(vo)-6.7(r)-5.6(o)-8.6(v)]TJ /Span<>> BDC 8.501 0 Td ( )Tj EMC 0.206 0 Td [(V)45.1(.)-12.2(A)-20.6(.,)-8( )]TJ -0.001 Tc 0.001 Tw -20.341 -1.218 Td [(V)-6.5(i)6.9(k)-21.8(tor)]TJ /Span<>> BDC 2.332 0 Td ( )Tj EMC [(V)52.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(K)11.8(a)0.7(k)11.9(ot)-7.8(k)-19.5(i)7.4(n)]TJ /T1_1 1 Tf -0.007 Tc 1.057 Tw -3.287 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf -0.002 Tc 1.052 Tw 10.139 0 Td [( V)-7.5(i)3.9(a)-7(che)-20(s)7.3(l)1.3(a)-6.3(v)]TJ /Span<>> BDC 5.364 0 Td ( )Tj EMC [(A)-14.6(.)]TJ /Span<>> BDC 2.13 0 Td ( )Tj EMC [(S)13.8(u)-4(v)5.6(o)-0.7(ro)-2.6(v)31.6(,)-2( )]TJ -0.001 Tc 0.001 Tw -17.632 -1.218 Td [(V)-6.5(i)6.9(k)-21.8(tor)]TJ /Span<>> BDC 2.332 0 Td ( )Tj EMC [(V)52.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(K)11.8(a)0.7(k)11.9(ot)-7.8(k)-19.5(i)7.4(n)]TJ /T1_1 1 Tf 0 Tc 0.896 Tw -3.287 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf -0.002 Tc 0.898 Tw [( V)-7.5(i)4(a)-7(che)-20(s)7.3(l)1.3(a)-6.4(v)]TJ /Span<>> BDC 15.811 0 Td ( )Tj EMC [(A)-14.6(.)]TJ /Span<>> BDC 1.976 0 Td ( )Tj EMC [(S)13.8(u)-4(v)5.6(o)-0.6(ro)-2.6(v)31.6(,)-2( )]TJ -0.001 Tc 0.001 Tw -17.786 -1.218 Td [(V)-6.5(i)6.9(k)-21.8(tor)]TJ /Span<>> BDC 2.332 0 Td ( )Tj EMC [(V)52.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(K)11.8(a)0.7(k)11.9(ot)-7.8(k)-19.5(i)7.4(n)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -3.287 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( M)10.5(i)7.9(k)5.3(h)4.8(a)-1.9(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)2.8(ga)-0.8(p)-4.9(ov)33.6(, V)-5.5(i)7.9(k)-20.8(t)1.4(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)1.7(k)12.9(o)1.4(t)-6.8(k)-18.4(i)8.4(n)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\222 \017\225 \032\026\020\017\022\032\233 $\ ORCID$)Tj /T1_1 1 Tf 0.365 Tw T* [(\225\031\r\024\030\024\r \200\016\004\036\f\035\026\r )0.5(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\b\017\030\031\030\020, )Tj 0.098 Tw T* (\026\f\f\017\f\021\036\027\021 \022\026\235\036\007\030\t \b\017\030\031\ \030\020\017\004\036\f\022\017\b \007\017\f\006\017\023\035\017\027, \024\ \002\030\026)Tj 0 Tw (-)Tj 0.214 Tw T* [(\024\r\026\021\036\035\034\027\024-\027\026\031\004\027\t\005-\022\035\026\ \f\021\036\030 )0.7(\253\204\213\212\207\230\210\273 )0.5(\207\205\211 )0.5(\017\n\036\027\017 )]TJ 0 Tw T* (\230.)Tj /Span<>> BDC ( )Tj EMC (\025\026\027\021\026; ORCID 0009-0008-0044-1259)Tj 0.123 Tw T* (\025\026\022\024\021\022\017\027 \200\017\022\021\024\030 \200\017\022\021\ \024\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\f\017\f\021\036\027\021 \022\026\235\036\007\030\t )Tj 0.498 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\b \007\017\f\006\017\023\035\ \017\027 \207\205\211 \017\n\036\027\017 \230.)Tj /Span<>> BDC ( )Tj EMC (\025\026\027\021\026; )Tj 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-0352-2317)Tj 0.476 Tw T* (\202\020\026\023\024\r \204\017\b\026\017\035 \202\027\007\030\036\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030 )Tj 0.666 Tw T* (\022\026\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b\ \007\017\f\006\017\023\035\017\027 \207\205\211 \017\n\036\027\017 )Tj 0 Tw T* (\230.)Tj /Span<>> BDC ( )Tj EMC (\025\026\027\021\026; ORCID 0000-0002-6569-7078)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS $ORCID$)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(V)-15(ia)-17(chesl)-15.9(av A. Suvor)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0009-6234-3248)Tj T* [(V)-15(ik)-24(t)17(or V. K)-15.9(ako)17(tk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0352-2317)Tj T* [(Mikhail A. A)-24.9(gapov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6569-7078)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 188.9979 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.261 Tw 8 0 0 8 42.5197 176.1632 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(eer)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(AF, Cr)-32(o)-16(ck)10(e)-12(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(SD, Bar)-23.9(r)-37(i)-24(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S. Bur)-23.9(den of)]TJ /Span<>> BDC ( )Tj EMC [(Gastr)-32(ointest)-31.9(inal, )]TJ -0.01 Tw -1.296 -1.25 Td [(L)-32(i)-16(ver, and P)40(ancr)-24(ea)15(t)-32(ic Diseases in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(U)13(ni)-24(ted S)15(t)15(a)15(tes. )]TJ /T1_2 1 Tf 0 Tw (Gastroenterology)Tj /T1_1 1 Tf (. )Tj 0.023 Tw 0 -1.25 TD (2015 Dec;149$7$:1731\2261741.e3.)Tj 0.01 Tc 0.373 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.326 0 Td (\214\017\r\026\027)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \206\026\031\f)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \214\017\f\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC [(\204.\202. \212\017\r\036\030\021\017\022\031\035\016\030\027\026\016)10( )]TJ 0.385 Tw -1.326 -1.25 Td (\002\024\035\036\027\034: \n\017\022\030\024\002\017\024\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\235\024\022\031\f\036 \r\027\017\n\026\027\017\016 \022\035\017\027\017\ \006\017\f\021\026. )Tj /T1_2 1 Tf -0.01 Tw (\255\240\244)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.129 Tw T* [(2023;5:20\22626. / L)-32(i)-16(vzan)]TJ /Span<>> BDC ( )Tj EMC (M.A., Gaus)Tj /Span<>> BDC ( )Tj EMC [(O.V., L)-32(isovsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC [(M.A. Di)-15.9(ver)-22(t)-32(icul)-15.9(ar )]TJ 0.047 Tw T* [(disease: gut micr)-32(obio)17(t)15(a in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(cl)-31(inic)-23.9(ian\241s p)25(r)-32.9(a)-17(c)-16(t)-32(ice. )]TJ /T1_2 1 Tf 0 Tw (RMJ)Tj /T1_1 1 Tf 0.047 Tw (. 2023;5:20\226)Tj 0 Tw T* (26.)Tj 0.051 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)60(ur)-10(si)]TJ /Span<>> BDC ( )Tj EMC 2.195 0 Td [(A, )0.5(S)-24(car)-24(pigna)15.1(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(C, )0.5(S)15(tr)-33(a)15(t, )0.5(LL, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 11.938 0 Td [(al. )0.5($2020$. )0.5(A)10(ut)-13(hor )0.5(Cor)-24(r)-23.9(ec)-16(t)-32(ion: )]TJ 0.179 Tw -15.429 -1.25 Td [(Col)30(onic di)-16(ver)-22(t)-32(icul)-15.9(ar disease. )]TJ /T1_2 1 Tf [(N)18(ature R)21(evie)10.1(ws Disease Pr)-37(imers.)]TJ /T1_1 1 Tf ( 6$1$. )Tj 0 Tw 29.055 11.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1038/s41572-020-0192-y)Tj 0 0 0 1 k /GS1 gs 0.015 Tc 0.532 Tw -1.847 -1.25 Td [(4)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.34 0 Td [(\212)0.5(\030\026)0.5(\023)0.5(\022\017)0.5(\027)0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\210)0.5(.\204)0.5(.)0.5(, \214)0.5(\026)0.5(\036)0.5(\002\027)0.5(\017)0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\214)0.5(.)0.5(\207.)0.5(,)0.5( \207)0.5(\026)0.5(\022\031)0.5(\035)0.5(\017\027)]TJ /Span<>> BDC 18.893 0 Td ( )Tj EMC [(\230)0.5(.\206)0.5(.,)0.5( \017)]TJ /Span<>> BDC 4.003 0 Td ( )Tj EMC [(\f\024)0.5(\026)0.5(\r\021)0.5(.)15( )]TJ 0 Tc 0.208 Tw -24.235 -1.25 Td (\212\017\r\036\030\021\017\022\031\035\016\030\027\026\016 \002\024\035\036\ \027\034 \021\024\035\f\021\024\005 \022\017\001\022\017: \022\035\017\027\ \017\004\036\f\022\026\016 \022\026\030\021\017\027\026, )Tj 0.177 Tw T* (\007\017\026\020\027\024\f\021\017\022\026, \035\036\004\036\027\017\036\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\026\022\021\017\022\026. \025\035\017\027\017\004\ \036\f\022\017\036 \030\036\022\024\n\036\027\007\026)Tj 0 Tw (-)Tj 0.283 Tw T* (\006\017\017 \217\024\f\f\017\005\f\022\024\020\024 \027\026\031\004\027\ \024\020\024 \n\036\007\017\006\017\027\f\022\024\020\024 \024\002\013\036\ \f\021\r\026 \021\036\030\026\023\036\r\021\024\r, )Tj 0.171 Tw T* (\203\026\031\004\027\024\020\024 \024\002\013\036\f\021\r\026 \020\026\f\ \021\030\024\220\027\021\036\030\024\035\024\020\024\r \217\024\f\f\017\017\ , \210\002\013\036\f\021\r\026 \020\026\f\021\030\024)Tj 0 Tw (-)Tj 0.22 Tw T* (\220\027\021\036\030\024\035\024\020\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\023\026\021\024\035\024\020\024\r \253\225\036\r\036\030\024-\003\ \026\023\026\007\273. )Tj /T1_2 1 Tf 0 Tw (\204\021\024\f\016\033\022\b\016\020\035\037\027\007\020\037\030 )Tj 0.044 Tc 1.575 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\n\016\024\021\037\030 \013\037\024\035\033\034\220\020\ \035\016\033\034\027\034\013\022\030.)Tj /T1_1 1 Tf [( 2023;2:33\22669.)44( )]TJ 0.022 Tc -0.022 Tw T* [(d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.725 0 Td (10.31146/1682-8658-ecg-210-2-33-69)Tj 0 0 0 1 k /GS1 gs 0.791 Tw [( /Dr)-32.9(apk)-15.9(ina)]TJ /Span<>> BDC ( )Tj EMC [(O.M.,)22( )]TJ 0 Tc 0.059 Tw -2.725 -1.25 Td [(L)-32(a)-24(zebnik)]TJ /Span<>> BDC ( )Tj EMC [(L.B., Bakul)-31(in)]TJ /Span<>> BDC ( )Tj EMC [(I.G., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30.1(onic di)-16(ver)-22(t)-32(icul)-15.9(ar disease: cl)-31(ini)]TJ 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 504.6396 56.0378 Tm (131)Tj ET endstream endobj 445 0 obj <>/Border[0 0 0]/H/N/Rect[289.739 183.459 382.77 174.163]/Subtype/Link/Type/Annot>> endobj 446 0 obj <>/Border[0 0 0]/H/N/Rect[296.757 103.459 428.761 94.1632]/Subtype/Link/Type/Annot>> endobj 448 0 obj <> endobj 447 0 obj <> endobj 65 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 66 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 67 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 68 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 69 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 455 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.143 Tw 10 0 0 10 70.8661 724.8299 Tm (\235\026\022\021\024\030\026 \030\024\f\021\026 $EGFR$ \004\036\030\036\ \030\036\006\036\023\021\024\030 2, \026\022\021\017\r\017\030\031\036\ )Tj 0 Tw (-)Tj 0.113 Tw 0 -1.218 TD (\n\t\005 \023\030\024\021\036\017\027\026\024\005, \024\027 \f\023\024\f\ \024\002\f\021\r\031\036\021 \235\024\f\235\024\030\017\035\017\030\024\r\ \026)Tj 0 Tw (-)Tj -0.003 Tw T* (\027\017\033 \002\036\035\022\024\r \024\027\t \023\035\024\021\027\t\b\ \f\024\036\007\017\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\f\021\030\024\005\022\036 )Tj 0.037 Tw T* [(\026\022\021\017\027\024\r\t\b \235\017\035\026\n\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \023\024\007\026\r\035\036\027\017\ \036\n )Tj 0.167 Tw T* [(\f\017\027\021\036\026 \002\036\035\022\024\r \023\035\024\021\027\t\b \ \f\024\036\007\017\027\036\027\017\005 $T)45(js$ \017, \f\035\036\007\024)]TJ 0 Tw (-)Tj 0.51 Tw T* [(\r\026\021\036\035\034\027\024, )0.6(\031\r\036\035\017\004\017\r\026\036\021 )0.5(\023\030\024\027\017\006\026\036\n\024\f\021\034 )0.6(\022\017\001\036\004\027\017\022\026 )]TJ 0.143 Tw 0 -1.218 TD ([57]. \203\026\030\031\001\036\027\017\036 \021\030\026\027\f\220\023\017\ \021\036\035\017\026\035\034\027\t\b \021\030\026\027\f\023\024\030\021\027\ \t\b )Tj 0.083 Tw 0 -1.218 TD (\023\031\021\036\005 \n\024\032\036\021 \r\t\r\026\021\034 \007\026\035\ \034\027\036\005\001\031\033 \021\030\026\027\f\035\024\022\026\006\017\033\ \023\026)Tj 0 Tw (-)Tj 0.203 Tw T* (\021\024\020\036\027\027\t\b \026\020\036\027\021\024\r \017, \f\035\036\ \007\024\r\026\021\036\035\034\027\024, \f\023\024\f\024\002\f\021\r\024\ \r\026\021\034 )Tj 0.282 Tw T* (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\033 \n\027\024\020\ \017\b \022\017\001\036\004\027\t\b \026\002\024\035\036\r\026\027\017\005\ . )Tj 0.142 Tw T* (\217\036\031\035\034\021\026\021\t \023\024\022\026\026\035\017, \004\021\ \024 \023\030\024\002\017\024\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\002\017\024\021\017\022\017 )Tj 0.025 Tw T* (\024\022\026\t\r\026\033\021 \027\026\004\017\021\036\035\034\027\024\036\ \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\036 \024\027\031)Tj 0 Tw (-)Tj 0.017 Tw 0 -1.218 TD (\035\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\n\017 \023\035\026\006\036\002\024. )Tj 0.093 Tw 0 -1.218 TD (\225\035\036\007\031\036\021 \024\021\n\036\021\017\021\034 \027\026\004\ \017\021\036\035\034\027\031\033 \027\036\024\007\027\024\030\024\007\027\ \024\f\021\034 \r\t)Tj 0 Tw (-)Tj 0.23 Tw 0 -1.218 TD (\002\030\026\027\027\t\b Ahmadi \017\f\f\035\036\007\024\r\026\027\017\005\ . \025\024\020\007\026 \026\027\026\035\017 \023\030\024)Tj 0 Tw (-)Tj 0.4 Tw T* (\r\024\007\017\035\f\016 \024\021\007\036\035\034\027\024 \007\035\016 \023\ \030\024\002\017\024\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\002\017\024\021\017\022\026, )Tj 0.222 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\t\021\031\036\n\t\b, \023\024\035\031\004\026\r\001\017\b \017\ \f\022\035\033\004\017\021\036\035\034\027\024 \023\030\024\002\017\024)Tj 0 Tw (-)Tj 0.028 Tw T* [(\021\017\022\017, \027\026\002\035\033\007\026\035\024\f\034 \027\026\004\ \017\021\036\035\034\027\024\036 )0.5(\f\027\017\032\036\027\017\036 \024\027\031\035\017\027\026 )]TJ 0 Tw T* ([57,60,61].)Tj /T1_1 1 Tf 0 -2.436 TD (\213\020\035\022\025\037\021\035\016\033\022\037\027\007\020\037\030 \035\ \016\033\037\f\022\030)Tj /T1_0 1 Tf 0.382 Tw 0 -1.218 TD (\225\024\020\035\026\f\027\024 \022\035\017\027\017\004\036\f\022\017\n \ \030\036\022\024\n\036\027\007\026\006\017\016\n 2015 \020\024\007\026, \ )Tj 0.334 Tw T* (\n\036\007\017\022\026\n\036\027\021\024\027\024\036 \035\036\004\036\027\ \017\036 \027\036\024\f\035\024\032\027\036\027\027\024\020\024 \007\017\ \r\036\030)Tj 0 Tw (-)Tj 0.366 Tw T* (\021\017\022\031\035\017\021\026 \016\r\035\016\036\021\f\016 \022\024\027\ \f\036\030\r\026\021\017\r\027\t\n, \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017)Tj 0 Tw (-)Tj 0.174 Tw T* (\036\n \026\027\021\017\002\017\024\021\017\022\024\021\036\030\026\023\017\ \017, \220\235\235\036\022\021\017\r\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 )Tj 0.076 Tw T* (\026\220\030\024\002\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\220\030\024\002\024\r, \032\017\007\022\031\033 \007\017\036\ \021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\235\031\017\024\027\027\031\033 )Tj 0.291 Tw T* (\021\036\030\026\023\017\033 [59]. \204\036\032\007\031 \021\036\n, \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\024\007\027\017\b \030\036\022\024)Tj 0 Tw (-)Tj 0.281 Tw T* (\n\036\027\007\026\006\017\016\b 2022 \020\024\007\026 \031\022\026\026\ \027\024, \004\021\024 \026\027\021\017\n\017\022\030\024\002\027\024\005\ )Tj 0.465 Tw T* (\021\036\030\026\023\017\017 \n\024\032\027\024 \017\002\036\032\026\021\ \034 \031)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\022\024\n\023\036\021\036\027\021\027\t\b )Tj 0.395 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\f\035\024\032\027\036\027\027\t\n \007\017\r\036\030\021\017\ \022\031\035\017\021\024\n \002\036 )Tj 0.155 Tw T* (\f\017\f\021\036\n\027\t\b \023\030\024\016\r\035\036\027\017\005 \017\027\ \235\036\022\006\017\017 [4,62,63,64,65,66]. )Tj 0.408 Tw T* (\025\026\022 \f\035\036\007\f\021\r\017\036, \017\021\026\035\034\016\027\ \f\022\024\036 \b\017\030\031\030\020\017\004\036\f\022\024\036 \024\002\ \013\036)Tj 0 Tw (-)Tj -0.013 Tw T* [(\f\021\r\024 )0.5([67], )0.5(\200\f\036\n\017\030\027\024\036 )0.5(\024\002\013\036\f\021\r\024 )0.5(\027\036\024\021\035\024\032\027\024\005 )0.6(\b\017\030\031\030\020\017\017 )]TJ 0.082 Tw T* ([68], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \202\n\036\030\017\022\026\027\f\022\026\016 \206\026\ \f\021\030\024\220\027\021\036\030\024\035\024\020\017\004\036\f\022\026\ \016 )Tj 0.014 Tw T* (\026\f\f\024\006\017\026\006\017\016 [62] \030\036\022\024\n\036\027\007\ \031\033\021 \017\002\017\030\026\021\036\035\034\027\024\036 \023\030\017\ \n\036)Tj 0 Tw (-)Tj 0.051 Tw T* (\027\036\027\017\036 \023\030\024\021\017\r\024\n\017\022\030\024\002\027\ \t\b \023\030\036\023\026\030\026\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036 \030\031\021\017\027\027\024\036 )Tj 0.194 Tw T* [(\023\030\017\n\036\027\036\027\017\036 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 6.331 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.612 0 Td [(\024\f\021\030\t\n )0.5(\027\036\024\f\035\024\032\027\036\027\027\t\n )]TJ 0 Tw -11.943 -1.218 Td (\007\017\r\036\030\021\017\022\031\035\017\021\024\n [4,69].)Tj 0.004 Tw T* [(\200 \f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\ \036 v)-15(an Dijk S.T. \002\t\035\017 \023\030\024\026\027\026)]TJ 0 Tw (-)Tj 0.028 Tw T* [(\035\017\017\030\024\r\026\027\t \030\036\031\035\034\021\026\021\t )0.5(\007\r\031\b \024\023\031\002\035\017\022\024\r\026\027\027\t\b \017\f\f\ \035\036)]TJ 0 Tw (-)Tj -0.031 Tw T* (\007\024\r\026\027\017\005, \f\030\026\r\027\017\r\026\033\013\017\b \026\ \027\021\017\002\026\022\021\036\030\017\026\035\034\027\031\033 \021\036\ \030\026\023\017\033 )Tj 0.266 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\026\027\021\017\002\017\024\021\017\022\024\r\031\033 \021\036\030\ \026\023\017\033 $\017\f\f\035\036\007\024\r\026\027\017\036 A)36(VOD )]TJ 0.272 Tw T* ([62] \017)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036 DIA)44(BOL)35(O [64,65]$. \203\026)]TJ /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 )Tj 0.111 Tw T* (\026\027\026\035\017\026 \030\036\031\035\034\021\026\021\024\r \035\036\ \004\036\027\017\016 \002\024\035\036\036 1000 \023\026\006\017\036\027\021\ \024\r )Tj -0.04 Tw T* (\002\t\035 \f\007\036\035\026\027 \r\t\r\024\007, \004\021\024 \024\021\f\ \031\021\f\021\r\017\036 \021\036\030\026\023\017\017 \026\027\021\017\002\ \017\024\021\017)Tj 0 Tw (-)Tj 0.079 Tw T* (\022\026\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\f\035\024\032\027\036\027\027\024\n \007\017\r\036\030\021\017\ \022\031\035\017\021\036 \027\036 \023\030\036\007\023\024)Tj 0 Tw (-)Tj -0.041 Tw T* (\035\026\020\026\036\021 \002\024\035\034\001\017\b \030\017\f\022\024\r\ \007\035\016 \023\026\006\017\036\027\021\026, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \024\027\024 )Tj 0.121 Tw T* (\027\036 \031\r\036\035\017\004\017\r\026\036\021 \021\016\032\036\f\021\ \034 \007\017\r\036\030\021\017\022\031\035\017\021\026, \027\036 \031\r\ \036\035\017\004\017)Tj 0 Tw (-)Tj 0.078 Tw T* (\r\026\036\021 \001\026\027\f \030\036\006\017\007\017\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022 \030\036\036\022\006\017\017 \021\024\035\f\021\024\005 \ \022\017\001\022\017 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\n \027\026\002\035\033\007\036\027\017\ \017 [10].)Tj 0.017 Tw T* (\204\024\007\031\035\016\006\017\016 \n\017\022\030\024\002\017\024\021\t\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ )Tj 0 Tw (-)Tj 0.107 Tw T* (\027\017 \002\t\035\026 \023\030\024\007\036\n\024\027\f\021\030\017\030\ \024\r\026\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \f\b\036\n )Tj -0.013 Tw T* (\021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \030\017\235\026\022\f\017\ \n\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\002\017\024\021\017)Tj 0 Tw (-)Tj 0.101 Tw T* (\022\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\ \007\024\r\026\027\017\005 \030\017\235\026\022\f\017\n\017\027 )Tj 0.005 Tw 23.244 64.543 Td (\023\030\017\n\036\027\016\035\f\016 \007\035\016 \021\036\030\026\023\017\ \017 \f\017\n\023\021\024\n\026\021\017\004\036\f\022\017\b \235\024\030\ \n \027\036)Tj 0 Tw (-)Tj 0.094 Tw T* (\024\f\035\024\032\027\036\027\027\024\005 \007\017\r\036\030\021\017\022\ \031\035\016\030\027\024\005 \002\024\035\036\027\017. \217\036\031\035\ \034\021\026\021\t )Tj 0.088 Tw T* (\023\030\017\n\036\027\036\027\017\016 \007\026\027\027\024\005 \f\b\036\ \n\t \021\036\030\026\023\017\017 \002\t\035\017 \024\002\027\026\007\036\ \032\017)Tj 0 Tw (-)Tj 0.144 Tw T* (\r\026\033\013\017\n\017 \027\036 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \022\024\027\021\030\024\035\016\ \f\017\n\023)Tj 0 Tw (-)Tj 0.027 Tw T* (\021\024\n\024\r, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\036 \n\017\022\030\024\002\017\024\021\t \022\017\001\ \036\004)Tj 0 Tw (-)Tj 0.064 Tw T* (\027\017\022\026, \r\022\035\033\004\026\016 \f\027\017\032\036\027\017\036\ \022\024\035\017\004\036\f\021\r\026 \021\026\022\017\b \002\026\022\021\ \036\030\017\005, )Tj 0 Tw 0 -1.218 TD (\022\026\022 )Tj /T1_1 1 Tf 0.212 Tw 1.83 0 Td [(R)19(osebur)-36.9(ia, V)33.1(eillonella, S)28(trep)13(tococcus, Haemophilus )]TJ /T1_0 1 Tf 0 Tw -1.83 -1.218 Td ([25])Tj /T1_1 1 Tf 0.132 Tw [(, Akk)17(er)-13.9(mansia)]TJ /T1_0 1 Tf ( [57]. \217\017\235\026\022\f\017\n\017\027 \f\027\017\032\026\036\021 \f\ \036\022\030\036)Tj 0 Tw (-)Tj 0.206 Tw 0 -1.218 TD (\006\017\033 \023\030\024\r\024\f\023\026\035\017\021\036\035\034\027\t\b\ \006\017\021\024\022\017\027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\017-\026 \027\017\022\024\005 )Tj 0.096 Tw T* (\023\036\030\024\030\026\035\034\027\024\005 \002\017\024\007\024\f\021\031\ \023\027\024\f\021\017 \n\026\035\024 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r )Tj 0 Tw T* (\n\017\022\030\024\002\017\024\021\t \022\017\001\036\004\027\017\022\026\ [14,69].)Tj 0.131 Tw T* [(\200 )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(T)35(ARGET )0.5(3 )0.5(\022\030\026\021\022\024\r\030\036\n\036\027\027\024\036 )0.5(\023\024\r\021\024\030)]TJ 0 Tw (-)Tj 0.214 Tw 0 -1.218 TD (\027\024\036 \035\036\004\036\027\017\036 \030\017\235\026\022\f\017\n\017\ \027\024\n \027\036 \024\022\026\t\r\026\035\024 \r\017\007\017\n\024)Tj 0 Tw (-)Tj 0.204 Tw 0 -1.218 TD (\020\024 \007\024\035\020\024\f\030\024\004\027\024\020\024 \r\024\007\036\ \005\f\021\r\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )Tj 0.007 Tw 0 -1.218 TD (\n\017\022\030\024\002\017\024\021\t \022)Tj /Span<>> BDC ( )Tj EMC (\030\017\235\026\022\f\017\n\017\027\031, \030\017\235\026\n\023\017\006\ \017\027\031 \017\035\017 \027\036\030\017)Tj 0 Tw (-)Tj 0.007 Tw T* [(\235\026\n\017\006\017\027\024\r\t\n \026\027\021\017\002\017\024\021\017\ \022\026\n, )0.5(\004\021\024 \007\036\035\026\036\021 \030\017\235\026\022\f\017\n\017\027\ )]TJ 0.302 Tw T* (\023\030\036\023\026\030\026\021\024\n \r\t\002\024\030\026 \007\035\016\ \035\036\004\036\027\017\016 \007\017\r\036\030\021\017\022\031\035\016\ \030\027\024\005 )Tj 0 Tw T* (\002\024\035\036\027\017 [70].)Tj /T1_2 1 Tf 0 -2.436 TD (\034\n\017\005\201\b\005\235 \f\016\005\b\020\004\005\b\f\005\240\013\235\ )Tj /T1_0 1 Tf 0.045 Tw 0 -1.218 TD (\217\024\035\034 \n\017\022\030\024\002\017\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \r\024\f\023\026\035\036\027\017\016 \007\017\ \r\036\030\021\017\022\031)Tj 0 Tw (-)Tj -0.059 Tw T* (\035\026 \021\026\022\032\036 \023\024\007\021\r\036\030\032\007\026\036\ \021\f\016 \027\026\035\017\004\017\036\n \024\021\r\036\021\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 )Tj -0.064 Tw T* (\024\f\035\024\032\027\036\027\027\t\b \235\024\030\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \235\036\022\026\035\034\027\024\005 \021\030\ \026\027\f\023\035\026\027)Tj 0 Tw (-)Tj 0.12 Tw T* (\021\026\006\017\017. \210\023\017\f\026\027\t \f\035\031\004\026\017 \030\ \036\n\017\f\f\017\017 \030\036\006\017\007\017\r\017\030\031\033\013\036\ \020\024 )Tj -0.019 Tw T* (\007\017\r\036\030\021\017\022\031\035\017\021\026, \027\036 \023\024\007\ \007\026\033\013\036\020\024\f\016 \b\017\030\031\030\020\017\004\036\f\022\ \024\n\031 \035\036)Tj 0 Tw (-)Tj 0.082 Tw T* (\004\036\027\017\033, \023\024\f\035\036 \235\036\022\026\035\034\027\024\ \005 \021\030\026\027\f\023\035\026\027\021\026\006\017\017 [71]. \025)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.225 Tw T* [(\032\026\035\036\027\017\033, )0.5(\021\026\022\032\036 \024\023\017\f\026\027 )0.5(\f\035\031\004\026\005, )0.5(\022\024\020\007\026 \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\022\017 )Tj 0.247 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\034\033, )0.5(\023\036\030\036\027\036\f\001\036\005 \235\036\022\026\035\034)]TJ 0 Tw (-)Tj 0.189 Tw T* [(\027\031\033 )0.5(\021\030\026\027\f\023\035\026\027\021\026\006\017\033 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 10.683 0 Td [(\023\024\r\024\007\031 )0.5(\017\027\235\036\022\006\017\017, )0.6(\r\t\r\026\027)]TJ 0 Tw (-)Tj -0.035 Tw -10.683 -1.218 Td (\027\024\005 \002\026\022\021\036\030\017\036\005 )Tj /T1_1 1 Tf [(Clostr)-36.9(idioides dif\241cile)]TJ /T1_0 1 Tf (, \023\024\f\035\036 \023\030\024\006\036\007\031\030\t )Tj 0.254 Tw T* (\030\026\r\017\035\f\016 \023\036\030\r\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\021\024\030\017\017 \220\023\017\024\007 \007\017\r\036\030\021\017\ \022\031\035\017\021\026 )Tj 0.137 Tw T* ([17]. \237\021\017 \007\026\027\027\t\036 \f\r\017\007\036\021\036\035\034\ \f\021\r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017 )Tj 0.072 Tw T* (\007\026\035\034\027\036\005\001\036\020\024 \020\035\031\002\024\022\024\ \020\024 \017\031\004\036\027\017\016 \007\026\027\027\024\020\024 \027\ \026\023\030\026\r\035\036)Tj 0 Tw (-)Tj 0.006 Tw T* (\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\036\005 \023\024\007\002\024\030\026\ \n\017\022\030\024\002\017\024\021\t \022\026\035\026 \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\027)Tj 0 Tw (-)Tj T* (\022\030\036\021\027\024\n\031 \n\017\022\030\024\002\017\024\n\031 \030\ \036\006\017\023\017\036\027\021\026.)Tj 0.951 Tw T* (\200 \027\026\f\021\024\016\013\017\005 \n\024\n\036\027\021 \023\030\024\ \r\024\007\016\021\f\016 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 1.157 Tw T* (\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\204\036\n\024\030\017\026\035\034\027\024\n )0.5(\n\036\007\017\006\017\027\f\022\024\n \006\036\027\021\030\036 )]TJ 0.923 Tw T* (\204\026\f\f\026\004\031\030\036\027\f\022\024\020\024 \031\027\017\r\036\ \030\f\017\021\036\021\026. \215\030\036\007\023\024\035\026\020\026\036\ \n\026\016 )Tj 0.199 Tw T* (\006\036\035\034 \220\021\024\020\024 \023\030\024\036\022\021\026)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\030\036\007\036\035\017\021\034 \024\f\031\013\036\f\021\r\ \017\n\024\f\021\034, )Tj 0.4 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \235\036\022\026\035\034\027\024\ \005 \021\030\026\027\f)Tj 0 Tw (-)Tj 0.008 Tw T* (\023\035\026\027\021\026\006\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \007\017\r\036\030\021\017\022\031\035\017\021\ \026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.076 Tw T* (\027\017\036\n \022\035\017\027\017\004\036\f\022\017\b \030\036\031\035\ \034\021\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\026 \n\017\022\030\024\002\017\024)Tj 0 Tw (-)Tj T* (\n\026 [72].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 176.8198 Tm (\023\232\023\037\226\232)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.02 Tw 10 0 0 10 303.3071 152.4638 Tm [(\204\017\022\030\024\002\017\024\021\026 )0.5(\024\022\026\t\r\026\036\021 )0.6(\027\026\004\017\021\036\035\034\027\024\036 )0.6(\r\035\017\016\027\017\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 20.366 0 Td (\030\026)Tj 0 Tw (-)Tj -0.076 Tw -20.366 -1.218 Td (\r\017\021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \007\017\r\036\ \030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\017. \ )Tj 0.392 Tw T* [(\225\027\017\032\036\027\017\036 )0.5(\022\024\035\017\004\036\f\021\r\026)]TJ /T1_1 1 Tf [( )0.5(Bacteroidetes, )0.5(F)24(usobacter)-36.9(ium, )]TJ /T1_0 1 Tf 0 Tw T* (\022\035\026\f\021\036\030\024\r)Tj /T1_1 1 Tf -0.007 Tw [( Clostr)-36.9(idium IV )]TJ /T1_0 1 Tf 0 Tw (\017)Tj /T1_1 1 Tf -0.007 Tw /Span<>> BDC ( )Tj EMC (IX, Lactobacillaceae, )Tj /T1_0 1 Tf (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj -0.084 Tw T* [(\007\030\031\020\017\b )0.6(\n\017\022\030\024\024\030\020\026\027\017\n\024\r, )0.5(\024\002\035\026\007\026\033\013\017\b )0.6(\023\030\024\021\017\r\024\r\024\f\023\026)]TJ 0 Tw (-)Tj 0.112 Tw T* (\035\017\021\036\035\034\027\t\n\017 \f\r\024\005\f\021\r\026\n\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\027\t\b \f\017\027\021\036\017\030\024\r\026\021\034\ )Tj 0.492 Tw T* [(\022\024\030\024\021\022\024\006\036\023\024\004\036\004\027\t\036 )0.6(\032\017\030\027\t\036 )0.5(\022\017\f\035\024\021\t, )0.6(\031\r\036\035\017\004\036\027\017\036 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (130)Tj ET endstream endobj 454 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 335.9485 42.7216 Tm [(F)20(eatur)31(es of\022th)11(e gut micr)20(obiota in th)11(e\022path)11(ogenesis and )]TJ 3.366 -1 Td [(clinical cour)20(se of\022div)12(er)-20(ticular disease $r)31(e)11(vie)11(w$)]TJ -42.49 1 Td [(\033\025\013\n \024\b\007\017\025\210\b\025\026\240 \016\022\223\005\026\ )11(\025\020)10(\f\t\f\001\f \b\022\007)-10(\013\b\t\b\213\f\205\007)10(\025\024 \026)11(\f\213\f\t\b\b )]TJ 0 -1 TD [(\217\b\016\f\017\026\b\007\220\013\017\t\025\255 \210\025\013\f\001\t\b\ $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.417 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\030\024\r\024\f\023\026\035\017\021\036\035\034\027\t\b \022\035\036\ \021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\036 )Tj 0.113 Tw 0 -1.218 TD (\021\024\035\f\021\024\005 \022\017\001\022\017 [49]. \210\021\f\033\007\ \026 \f\035\036\007\031\036\021, \004\021\024 \017\f\021\024\013\036\027\ \017\036 )Tj 0.044 Tw T* (\007\026\027\027\t\b \021\026\022\f\024\027\024\r \n\024\032\036\021 \r\t\ \f\021\031\023\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \024\007\027\024\020\024 )Tj 0.186 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\b \r\036\027\034\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \r\024\f\023\026\035\017\021\036\035\ \034\027\t\b )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \007\017\r\036\030\021\017\022\031\ \035\016\030\027\024\005 \002\024\035\036\027\017.)Tj 0.006 Tc -0.012 Tw T* [(S)-24(car)-24(pigna)15(t)17(o C., Bar)-24(bar)-32.9(a G. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\036\007\024\f\021\026\r\017\035\017 \007\026\027\ )Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.297 Tw 0 -1.218 TD (\027\t\036, \f\r\017\007\036\021\036\035\034\f\021\r\031\033\013\017\036\ \024\002 \031\n\036\027\034\001\036\027\017\017 \023\030\036\007\f\021\026\ )Tj 0 Tc 0 Tw (-)Tj 0.006 Tc -0.006 Tw 0 -1.218 TD (\r\017\021\036\035\034\f\021\r\026 )Tj /T1_2 1 Tf 0.226 Tw 5.033 0 Td [(Bacteroidetes, F)23.9(usobacter)-37(ium, Clostr)-37(idium)6( )]TJ 0.258 Tw -5.033 -1.218 Td (cluster IV )Tj /T1_1 1 Tf -0.006 Tw (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0.258 Tw 5.49 0 Td (IX, Lactobacillaceae)Tj /T1_1 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \002\026\022\021\036\030\017)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.449 Tw -5.49 -1.218 Td (\026\035\034\027\t\b \001\021\026\n\n\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\027\006\017\026\035\034\027\t\n\017 \023\030\024\021\017\ \r\024\r\024\f)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.528 Tw T* (\023\026\035\017\021\036\035\034\027\t\n\017 \f\r\024\005\f\021\r\026\n\017\ \017\035\017 \023\030\024\007\031\006\036\027\021\024\r \022\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.175 Tw T* (\030\024\021\022\024\006\036\023\024\004\036\004\027\t\b \032\017\030\027\ \t\b \022\017\f\035\024\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\f\036\b \235\024\030\n\026\b)6( )]TJ 0.17 Tw 0 -1.218 TD (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017 [2,23], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\r\036\035\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.224 Tw 0 -1.218 TD [(\027\017\017 \004\017\f\035\036\027\027\024\f\021\017 R)10.9(osebur)-36.9(ia hominis \017)]TJ /Span<>> BDC ( )Tj EMC [(Akk)10(er)-16(mansia)6( )]TJ 0 Tw 0 -1.218 TD [(muc)-24(iniphil)-15.9(a [50].)]TJ 0.002 Tc 0.372 Tw T* (\210\f\027\024\r\t\r\026\016\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\027\t\b \007\026\027\027\t\b \026\027\026\035\ \017\026 \035\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.271 Tw T* [(\021\036\030\026\021\031\030\t, \007\026\035\034\027\036\005\001\036\036\ \017\031\004\036\027\017\036 \f\024\f\021\026\r\026 \022\017\001\036\004\ \027\024\005)2( )]TJ 0.195 Tw T* (\n\017\022\030\024\002\017\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\016 \036\036 \n\036\021\026\002\024\035\017\021\024\ \r \027\026)Tj /Span<>> BDC ( )Tj EMC [(\021\036\004\036\027\017\036)1.9( )]TJ 0.663 Tw T* [(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017 \n\024\020\031\021 \f\023\024\f\024\002\f\021\r\024\r\026\021\034\ )2( )]TJ 0.316 Tw T* (\030\026\030\026\002\024\021\022\036 \024\023\021\017\n\026\035\034\027\ \t\b \023\024\007\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC [(\r\024\007\036\005\f\021\r\017\033)2( )]TJ 0.378 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\n\017\022)Tj /Span<>> BDC ( )Tj EMC 3.147 0 Td (\030\024\002\017\024\n \017)Tj /Span<>> BDC ( )Tj EMC 4.854 0 Td [(\022 \f\021\030\026\021\036\020\017\017 \r\036\007\036\027\017\016 \023\026\ \006\017\036\027\021\024\r)2( )]TJ 0 Tw -8.001 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \023\026\021\024\035\024\020\017\036\005.)Tj /T1_3 1 Tf 0 Tc 0.055 Tw 0 -2.436 TD (\215\007\t\213\007\t\r \017)Tj /Span<>> BDC ( )Tj EMC 4.918 0 Td [(\006\007\220\t\n\206\020\f\006\013\212 )0.5(\b\005)]TJ /Span<>> BDC ( )Tj EMC [(\210\013\017\016\007\217\013\007\210 )0.5(\004\016\013)]TJ /Span<>> BDC ( )Tj EMC (\t\013\006\n\016)Tj 0 Tw (-)Tj -4.918 -1.218 Td (\f\013\017\211\235\016\b\007\206 \217\007\n\220\b\013)Tj /T1_2 1 Tf 0 -1.218 TD (\201\033\022\b\016\020\016\020\022\016 \f\033\034\025\022\034\035\022\021\ \034\036)Tj /T1_1 1 Tf 0.244 Tw T* (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \030\ \024\035\034 \023\030\024\002\017\024\021\017\022\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017)Tj 0 Tw (-)Tj 0.162 Tw T* (\035\026\022\021\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \007\017\r\036\030\021\017\022\031\035\016\030\ \027\024\005 \002\024\035\036\027\017 \027\036\007\024)Tj 0 Tw (-)Tj 0.001 Tw T* (\f\021\026\021\024\004\027\024 \017\031\004\036\027\026. \203\036\021 \031\ \002\036\007\017\021\036\035\034\027\t\b \007\026\027\027\t\b \r\035\017\ \016\027\017\016 )Tj 0.351 Tw T* (\022\024\027\022\030\036\021\027\024\020\024 \001\021\026\n\n\026 \023\030\ \024\002\017\024\021\017\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\031\021\017 \r\024\027\017\022)Tj 0 Tw (-)Tj 0.195 Tw T* (\027\024\r\036\027\017\016 \024\002\024\f\021\030\036\027\017\016 \007\017\ \r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017 \017\035\017 )Tj 0.297 Tw T* [(\r\024\027\017\022\027\024\r\036\027\017\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\024\235\017\035\026\022\021\017\022\031 )0.5(\024\023\030\036\007\036\035\036\027\027\t\b \024\f)]TJ 0 Tw (-)Tj 0.079 Tw T* [(\035\024\032\027\036\027\017\005 \r\r\017\007\031 \024\021\f\031\021\f\021\ \r\017\016 \027\026\007\036\032\027\t\b )0.5(\n\036\021\026\026\027\026\035\017\024\r )]TJ 0.195 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\030\036\004\017\r\t\b \030\036\031\035\034\021\ \026\021\024\r \027\036\022\024\021\024\030\t\b \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj 0.182 Tw T* [(\r\026\027\017\005 )0.5([4]. \211\023\030\026\r\035\036\027\017\036 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\033 \026)Tj /Span<>> BDC ( )Tj EMC 17.274 0 Td (\023\030\024\007\031\022\021\026\n\017 )Tj 0.056 Tw -17.274 -1.218 Td (\023\017\021\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\022\026\030\f\021\r\026\n\017 \225\221\202 \007\024)Tj /Span<>> BDC ( )Tj EMC (\f\017\b \023\024\030 \027\036 \024\007\024\002\030\017\035\024 )Tj 0.138 Tw T* (\027\017 \024\007\017\027 \023\030\024\002\017\024\021\017\004\036\f\022\ \017\005 \023\030\036\023\026\030\026\021 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \021\036\030\026)Tj 0 Tw (-)Tj T* (\023\036\r\021\017\004\036\f\022\024\020\024 \f\030\036\007\f\021\r\026 \ [51].)Tj 0.274 Tw T* (\215\030\036\007\023\024\035\026\020\026\036\021\f\016, \004\021\024 \023\ \030\024\002\017\024\021\017\022\017 \017\020\030\026\033\021 \022\035\033\ \004\036\r\031\033 )Tj 0.148 Tw T* (\030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\031\035\016\006\017\017 \n\017\022\030\024\002\017\024\n\026 \ \022\017\001\036\004\027\017\022\026, \020\035\026\r\027\t\n )Tj 0.501 Tw T* (\024\002\030\026\024\n, \022\024\027\022\031\030\017\030\031\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\027\t\n\017 \002\026\022\021\036\030\017\016\ \n\017 )Tj 0.112 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\n\024\035\036\022\031\035\016\030\027\t\b \f\031\002\f\021\030\026\021\026\ \b )0.5(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017, \021\036\n \f\026)]TJ 0 Tw (-)Tj 0.513 Tw T* (\n\t\n \023\030\036\007\024\021\r\030\026\013\026\016 \023\026\021\024\035\ \024\020\017\004\036\f\022\031\033 \022\024\035\024\027\017\026\006\017\ \033 )Tj 0 Tw T* (\022\017\001\036\004\027\017\022\026. \200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \027\026\022\024\023\035\036\027\017\033 \235\ \036\022\026\035\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\007\017)Tj (-)Tj 0.172 Tw T* (\r\036\030\021\017\022\031\035\026\b \f\023\024\f\024\002\f\021\r\031\036\ \021 \026\f\021\024\005 \022\026\035\024\r\024\020\024 \f\024\007\036\030\ \032\017)Tj 0 Tw (-)Tj 0.181 Tw T* (\n\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\027\t\005 \020\030\026\007\017\036\027\021 \007\ \026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036 )Tj 0.038 Tw T* (\022\017\001\022\017, \004\021\024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \023\030\036\007\030\026\f\023\ \024\035\026\020\026\036\021 \022)Tj /Span<>> BDC ( )Tj EMC (\017\n\036)Tj 0 Tw (-)Tj 0.13 Tw T* (\027\036\027\017\033 \n\017\022\030\024\235\035\024\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\017\002\t\021\024\004\027\024\n\031 \002\026\022\021\036\030\017\026\035\ \034\027\024\n\031 )Tj 0.003 Tw T* (\030\024\f\021\031. \207\026\030\034\036\030\027\026\016 \235\031\027\022\ \006\017\016 \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017\ \027\026\030\031)Tj 0 Tw (-)Tj 0.107 Tw T* (\001\026\036\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\024\006\017\030\031\036\021 \r\024\f\023\026\035\017\021\036\ \035\034\027\031\033 \030\036\026\022\006\017\033 \023\024)Tj 0 Tw (-)Tj 0.284 Tw T* [(\f\030\036\007\f\021\r\024\n )0.6(\r\t\f\r\024\002\024\032\007\036\027\017\016 )0.5(\006\017\021\024\022\017\027\024\r. )0.6(\215\030\024\002\017\024\021\017\022\017 )]TJ 0.319 Tw T* [(\n\024\020\031\021 \r\026\017\n\024\007\036\005\f\021\r\024\r\026\021\034\ )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(t)17(oll-\023\024\007\024\002\027\t\n\017 \030\036\006\036\023)]TJ 0 Tw (-)Tj 0.191 Tw T* [(\021\024\030\026\n\017, )0.5(\004\021\024\002\t )0.6(\023\024\007\026\r\017\021\034 )0.5(\r\024\f\023\026\035\036\027\017\036 )0.6(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )]TJ 0 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \023\024\r\t\001\036\027\017\016 \017\n\n\031\027\027\024\ \005 \021\024\035\036\030\026\027\021\027\024\f\021\017 [52].)Tj 0.488 Tw 23.244 64.543 Td [(\225\021\036\023\036\027\034 )0.6(\022\024\035\024\027\017\026\006\017\017 )0.5(\022\017\001\036\004\027\017\022\026 )0.5(\023\030\024\002\017\024\021\017\004\036\f\022\024\005 )]TJ 0.042 Tw T* [(\n\017\022\030\024\235\035\024\030\024\005 )0.5(\027\026\004\017\021\036\035\034\027\024 )0.6(\030\026\035\017\004\026\036\021\f\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 17.492 0 Td [(\030\026\027\t\b )0.6(\017\027)]TJ 0 Tw (-)Tj 0.084 Tw -17.492 -1.218 Td [(\007\017\r\017\007\031\031\n\024\r. \025\026\022 \f\024\024\002\013\026\036\ \021 Q)-16(uigle)-10.9(y \213.\204., \023\030\024\002\017\024\021\017\022\017 )]TJ 0.333 Tw T* (\n\024\020\031\021 \n\024\007\017\235\017\006\017\030\024\r\026\021\034 \ \035\024\022\026\035\017\024\r\026\027\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\005\022\024\036 )Tj 0.307 Tw T* (\r\024\f\023\026\035\036\027\017\036, \023\030\017\f\031\021\f\021\r\031\ \033\013\036\036 \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.2 Tw T* (\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \n\036\032\007\031 \024\f\021\030\t\n\017 \023\030\ \017\f\021\031\023\026\n\017 \007\017\r\036\030\021\017)Tj 0 Tw (-)Tj 0.226 Tw 0 -1.218 TD (\022\031\035\017\021\026 [53,54]. \215\030\024\002\017\024\021\017\022\017\ \r\035\017\016\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\030\036\f\f\017\033 )Tj 0.341 Tw 0 -1.218 TD [(\020\036\027\024\r, )0.5(\f\r\016\026\027\027\t\b )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 9.019 0 Td [(\017\n\n\031\027\017\021\036\021\024\n, )0.5(\026\022\021\017\r\027\024\f\021\034 )0.6(\r\024\f)]TJ 0 Tw (-)Tj 0.291 Tw -9.019 -1.218 Td (\023\026\035\017\021\036\035\034\027\t\b \023\031\021\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\017 \017\n\n\031\027\027\t\b \n\026\030\022\036\030\024\ \r. )Tj 0.07 Tw T* (\237\021\024)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\026\036\021 \f\017\027\021\036 NF-\266B \022\035\036\ \021\024\022 \022\017\001\036\004\027\024\020\024 \220\023\017\021\036)Tj 0 Tw (-)Tj 0.242 Tw T* (\035\017\016, \n\017\021\024\020\036\027-\026\022\021\017\r\017\030\031\036\ \n\024\005 \023\030\024\021\036\017\027\022\017\027\026\t $MAPK$, )Tj 0.132 Tw T* [(Ak)-24(t, \030\036\006\036\023\021\024\030 \265, \026\022\021\017\r\017\030\031\ \036\n\t\005 \023\030\024\035\017\235\036\030\026\021\024\030\024\n \023\ \036)]TJ 0 Tw (-)Tj 0.139 Tw 0 -1.218 TD [(\030\024\022\f\017\f\024\n, CRP, )0.5(\017\027\021\036\030\035\036\005\022\017\027 )0.5($IL$-6, )0.5(IL-8, \235\026\022\021\024\030 )0.5(\027\036)]TJ 0 Tw (-)Tj 0.042 Tw 0 -1.218 TD (\022\030\024\026 \024\023\031\b\024\035\017 $TNF$-\256, IL-1\263 \017\ )Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\235\036\030\024\027 \265 $IFN-\265$ )Tj 0.091 Tw 0 -1.218 TD ([54]. \204\036\b\026\027\017\n\t \r\024\007\036\005\f\021\r\017\016 \023\ \030\024\002\017\024\021\017\022\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r)Tj 0 Tw (-)Tj 0.096 Tw T* [(\027\024\n \026\r\017\f\016\021 )0.5(\024\021 \022\024\027\021\026\022\021\026 )0.5(\023\030\036\007\023\024\035\026\020\026\036\n\024\020\024 )0.5(\030\024\007\026 \002\026\022)]TJ 0 Tw (-)Tj 0.18 Tw T* (\021\036\030\017\005 \f\024 \f\023\036\006\017\235\017\004\027\t\n\017 \030\ \036\006\036\023\021\024\030\026\n\017. \200\024\007\036\005\f\021\r\031\ \016 )Tj 0.324 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\036\027\017\036, \f\027\017\032\026\016 \002\026\022\ \021\036\030\017\026\035\034\027\031\033 \021\030\026\027\f\035\024\022\026\ )Tj 0 Tw (-)Tj 0.044 Tw T* (\006\017\033, \022\024\027\022\031\030\036\027\021\027\024 \017\027\020\017\ \002\017\030\031\016 \030\024\f\021 \023\026\021\024\020\036\027\027\t\b\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj -0.023 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \002\026\022\021\036\030\ \017\026\035\034\027\t\b \001\021\026\n\n\024\r \023\030\024\002\017\024\ \021\017\022\017 )Tj 0.063 Tw T* (\r\024\007\036\005\f\021\r\031\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \f\017\n\023\021\024\n\024\r \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030)Tj 0 Tw (-)Tj 0.046 Tw T* [(\021\017\022\031\035\016\030\027\024\005 )0.6(\002\024\035\036\027\034\033 )0.6([54]. )0.5(\224\026\022\032\036 )0.5(\023\030\024\002\017\024\021\017\022\017 )0.6(\r\t\t)]TJ 0 Tw (-)Tj 0.139 Tw T* (\r\026\033\021 \f\021\017\n\031\035\016\006\017\033 \f\017\027\021\036\026\ \002\036\035\022\024\r \023\035\024\021\027\t\b \f\024\036\007\017\027\036\ )Tj 0 Tw (-)Tj 0.109 Tw T* [(\027\017\005 $T)25(J$ $\022\035\026\031\007\017\027-1, \024\022\022\035\033\007\017\027 \017\ )]TJ /Span<>> BDC ( )Tj EMC [(Z)52(O-1$ \017)]TJ /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\036 )Tj -0.051 Tw T* (\021\030\026\027\f\220\023\017\021\036\035\017\026\035\034\027\024\020\024\ \220\035\036\022\021\030\017\004\036\f\022\024\020\024 \f\024\023\030\024\ \021\017\r\035\036\027\017\016, )Tj 0.171 Tw T* (\f\021\017\n\031\035\017\030\024\r\026\027\017\036 \f\036\022\030\036\006\ \017\017 \f\035\017\017 $\023\031\021\036\n \023\024\r\t\001\036\027\017\ \016 )Tj 0.045 Tw T* [(\031\030\024\r\027\016 )0.5(MUC2, )0.5(MUC3 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.173 0 Td [(MUC1 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.257 0 Td [(\220\023\017\021\036\035\017\026\035\034\027\t\b )0.6(\022\035\036\021\022\026\b )]TJ 0 Tw -12.43 -1.218 Td (\021\024\035\f\021\024\005 \022\017\001\022\017$ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\036 \031\030\024\r\027\016 \002\031\021\017\ \030\026\021\026 [55].)Tj 0.443 Tw T* (\212\030\031\020\024\005 \022\035\033\004\036\r\024\005 \220\035\036\n\036\ \027\021 \007\036\005\f\021\r\017\016 \023\030\024\002\017\024\021\017\022\ \024\r )Tj 0.274 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017 \026\022\035\033\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\f)Tj 0 Tw (-)Tj 0.159 Tw T* [(\r\036\027\027\024\n )0.5(\r\035\017\016\027\017\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 8.669 0 Td [(\n\024\021\024\030\017\022\031: )0.5(\017\n\036\027\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\036 )Tj 0.004 Tw -8.669 -1.218 Td (\n\017\022\030\024\002\017\024\n\026 \022\017\001\036\004\027\017\022\026\ \n\024\020\031\021 \r\t\r\026\021\034 \017\n\036\027\036\027\017\016 \ \026\022)Tj 0 Tw (-)Tj -0.018 Tw T* [(\021\017\r\026\006\017\017 )0.5(\027\036\030\r\027\t\b )0.6(\r\024\035\024\022\024\027 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.701 0 Td [(\023\024\f\035\036\007\031\033\013\036\005 )0.6(\027\036\005\030\024\027\027\024\005 )]TJ 0.249 Tw -11.701 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC [(\n\t\001\036\004\027\024\005 \007\017\f\235\031\027\022\006\017\017, \026\ \022\021\017\r\026\006\017\017 t)17.1(oll-\023\024\007\024\002\027\t\b )]TJ 0.066 Tw T* (\030\036\006\036\023\021\024\030\024\r [56] \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \r\024\f\023\026\035\017\021\036\ \035\034\027\024\005 \030\036)Tj 0 Tw (-)Tj 0.077 Tw T* (\026\022\006\017\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \023\036\030\017\r\017\f\006\036\030\026\035\034\027\ \t\b \021\022\026\027\036\005 [57,58], )Tj -0.028 Tw T* (\004\021\024 \f\023\024\f\024\002\f\021\r\031\036\021 \030\026\r\017\021\ \017\033 \007\017\r\036\030\021\017\022\031\035\036\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017)Tj 0 Tw (-)Tj T* (\022\031\035\016\030\027\024\005 \002\024\035\036\027\017.)Tj -0.068 Tw T* (Suez J. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r\t\f\022\026\026\027\024 \023\030\036\007\023\024\035\ \024\032\036\027\017\036, \004\021\024 \235\026\022\021\024)Tj 0 Tw (-)Tj -0.027 Tw T* [(\030\t, \f\036\022\030\036\021\017\030\031\036\n\t\036 \r\r\036\007\036\027\ \027\t\n\017 \r\017\007\026\n\017 L)-32(a)-17(c)-16(t)17(oba)-17(c)-23.9(ill)35(us, )]TJ 0.194 Tw T* (\027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 \017\027\020\017\002\ \017\030\031\033\021 $)Tj /T1_2 1 Tf [(e)-15(x viv)13(o)]TJ /T1_1 1 Tf ($ \030\024\f\021 \n\017\022\030\024)Tj 0 Tw (-)Tj 0.115 Tw T* (\002\017\024\n\026 \004\036\035\024\r\036\022\026 [59]. \237\021\024 \002\ \t\035\024 \024\002\024\f\027\024\r\026\027\024 \021\036\n, \004\021\024\ )Tj 0.334 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.04 0 Td [(\027\036\022\024\021\024\030\t\b )0.6(\f\035\031\004\026\016\b )0.5(\022\024\035\024\027\017\026\006\017\017 )0.5(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )]TJ 0.121 Tw -1.04 -1.218 Td [(\023\030\024\002\017\024\021\017\004\036\f\022\017\n\017 \001\021\026\n\n\ \026\n\017 L)-32(a)-17(c)-16(t)17(oba)-17(c)-24(ill)35(us \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.07 Tw T* (\021\024\r \235\024\030\n\017\030\024\r\026\035\f\016 \f\021\024\005\022\ \017\005 \007\035\017\021\036\035\034\027\t\005 \007\017\f\002\017\024,\ \004\021\024 )Tj 0.288 Tw T* [(\027\026\004\017\021\036\035\034\027\024 )0.6(\026\n\036\007\035\016\035\024 )0.5(\r\024\f\f\021\026\027\024\r\035\036\027\017\036 )0.5(\n\017\022\030\024\002\017\024)]TJ 0 Tw (-)Tj 0.032 Tw T* (\n\026 \022\026\022 \022\026\035\026, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.021 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036\n \021\036\030\026\023\017\017 \023\024\ \f\035\036 \035\036\004\036\027\017\016 \026\027\021\017\002\017\024\021\ \017\022\026\n\017 )Tj 0 Tw T* ([59].)Tj 0.117 Tw T* [(R)-10(amezani Ahmadi \002\t\035 \023\030\024\r\036\007\036\027 \n\036\021\026\026\ \027\026\035\017, \r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\021\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\030\t\005 \002\t\035\017 \r\022\035\033\004\036\027\t \007\036\r\016\021\ \034 \030\026\002\024\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\033 \r\035\017)Tj 0 Tw (-)Tj 0.099 Tw T* (\016\027\017\016 \023\030\017\036\n\026 \023\030\024\002\017\024\021\017\ \022\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\002\017\024\021\017\022\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\017 )Tj -0.083 Tw T* (\024\027\031\035\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036. \003\024\027\031\035\017\027 \016\r\035\016\ \036\021\f\016 \002\036\035\022\024\n \023\035\024\021)Tj 0 Tw (-)Tj 0.068 Tw T* (\027\t\b \022\024\027\021\026\022\021\024\r. \202\022\021\017\r\017\030\031\ \016 \030\036\006\036\023\021\024\030 \220\023\017\007\036\030\n\026\035\ \034\027\024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.5021 56.0378 Tm (129)Tj ET endstream endobj 452 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.15 Tw 10 0 0 10 70.8661 724.8299 Tm ([4,35]. \224\026\022\017\n \024\002\030\026\024\n, \r\t\001\036\031\023\ \024\n\016\027\031\021\t\036 \030\036\031\035\034\021\026\021\t )Tj 0.092 Tw 0 -1.218 TD (\023\024\007\021\r\036\030\032\007\026\033\021 \021\036\024\030\017\033 \ \f\021\030\031\022\021\031\030\027\t\b \017\n\036\027\036\027\017\005 \f\ \021\036\027)Tj 0 Tw (-)Tj 0.183 Tw T* [(\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\017\n\036\027\036\027\027\024\020\024 )0.5(\f\024\f\021\026\r\026 \n\026\021\030\017\022\f\026 )]TJ 0.017 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\023\030\016\n\024\n \031\004\026\f\021\017\017 )0.5(\n\017\022\030\024\002\017\024\021\t \022\026\022 )0.5(\024\f\027\024\r\027\t\b \023\026)]TJ 0 Tw (-)Tj 0.127 Tw T* (\021\024\020\036\027\036\021\017\004\036\f\022\017\b \235\026\022\021\024\ \030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \007\017\r\036\030\021\017\022\031\035\016\030\ )Tj 0 Tw (-)Tj T* (\027\024\005 \002\024\035\036\027\017.)Tj 0.035 Tw 0 -1.218 TD (\215\030\017 \024\f\035\024\032\027\036\027\027\t\b \235\024\030\n\026\b\ \007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\ \036\027\017 )Tj 0.023 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\024 \031\r\036\035\017\004\036\027\017\036 \220\022\ \f\023\030\036\f\f\017\017 \020\017\f\021\026\n\017\027\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.153 Tw T* (\020\017\f\021\026\n\017\027\024\r\t\b \030\036\006\036\023\021\024\030\024\ \r H1 \017)Tj /Span<>> BDC ( )Tj EMC (H2, \n\217\203\025 \r)Tj /Span<>> BDC ( )Tj EMC (\220\027\021\036\030\024)Tj 0 Tw (-)Tj 0.046 Tw T* [(\006\017\021\026\b )0.5(\021\024\035\f\021\024\005 \022\017\001\022\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\027\t\b )0.5(\007\017\r\036\030\021\017\022\031\035\017\021\024\n. )0.5(\237\021\017 )]TJ 0.04 Tw T* [(\030\036\031\035\034\021\026\021\t )0.5(\002\t\035\017 \023\030\036\007\035\024\032\036\027\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\036 )0.5(\024\f\027\024\r\t \007\035\016 )]TJ 0.305 Tw T* [(\002\031\007\031\013\017\b \023\024\021\036\027\006\017\026\035\034\027\t\ \b )0.5(\022\024\027\006\036\023\006\017\005 \035\036\004\036\027\017\016 \026\027\ \021\017)]TJ 0 Tw (-)Tj 0.141 Tw 0 -1.218 TD [(\020\017\f\021\026\n\017\027\027\t\n\017 )0.6(\023\030\036\023\026\030\026\021\026\n\017 )0.6($\026\027\021\026\020\024\027\017\f\021\026\n\017 )0.6(H1/H2$, )]TJ 0 Tw 0 -1.218 TD (\007\024\002\026\r\022\026\n\017 \007\017\026\n\017\027\024\024\022\f\017\ \007\026\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\002\017\024\021\017\022\026\n\017 [36].)Tj /T1_1 1 Tf 0.196 Tw 0 -2.436 TD (\027\007\201 \210\n\f\005\217\007\013\f\007\006 \017\013\001\n\205\b\007\ \206 \210\013\017\016\007\217\013\007\f\r \006)Tj /Span<>> BDC ( )Tj EMC (\004\005)Tj 0 Tw (-)Tj 0.062 Tw 0 -1.218 TD (\f\007\002\n\b\n\220\n \t\013\006\n\016\f\013\017\211\235\016\b\007\206\ \217\007\n\220\b\013 \013)Tj /Span<>> BDC ( )Tj EMC (\004\n\016\020\004\n\017\f\013)Tj 0 Tw (-)Tj T* (\006\r \013\213 \013\020\004\007\201\220\007\006\005\b\013\235)Tj /T1_0 1 Tf 0.195 Tw T* (\212\024\f\021\017\032\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \n\036\021\024\007\024\r \n\024\035\036\022\031\ \035\016\030\027\024\005 \002\017\024)Tj 0 Tw (-)Tj 0.222 Tw T* (\035\024\020\017\017, \021\026\022\017\b \022\026\022 \n\036\021\026\020\ \036\027\024\n\017\022\026, \023\030\024\021\036\024\n\017\022\026, \021\ \030\026\027\f)Tj 0 Tw (-)Tj 0.171 Tw T* (\022\030\017\023\021\024\n\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\002\024\035\024\n\017\022\026, \023\024\r\024\035\016\033\ \021 \007\024\f\021\026\021\024\004\027\024 )Tj 0.145 Tw T* (\007\036\021\026\035\034\027\024 \017\031\004\017\021\034 \n\017\022\030\ \024\002\017\024\021\031 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030)Tj 0 Tw (-)Tj -0.028 Tw T* (\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\034\033. \ \225\024\020\035\026\f\027\024 \017\f\f\035\036\007\024\r\026\027\017\016\ \n, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.321 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \235\024\030\n\026\n\017 \007\017\r\036\ \030\021\017\022\031\035\016\030\027\024\005 )Tj 0.036 Tw T* (\002\024\035\036\027\017 \017\n\036\033\021\f\016 \f\023\036\006\017\235\ \017\004\036\f\022\017\036 \n\024\004\036\r\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\235\036\022\026\035\034)Tj 0 Tw (-)Tj 0.106 Tw T* [(\027\t\036 \002\017\024\n\026\030\022\036\030\t, \b\026\030\026\022\021\036\ \030\017\031\033\013\017\036 )0.5(\017\n\n\031\027\027\t\005 )0.5(\024\021\r\036\021 )]TJ 0.274 Tw T* (\024\030\020\026\027\017\n\026 \b\024\016\017\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\002\017\024\021\017\004\036\f\022\017\036 \017\n\036\027\036\ \027\017\016. )Tj 0.202 Tw T* [(\215\030\036\007\023\024\035\026\020\026\036\021\f\016, )0.6(\004\021\024 )0.5(\024\023\030\036\007\036\035\036\027\027\t\036 )0.6(\n\036\021\026\002\024\035\017\004\036\f\022\017\036 )]TJ 0.172 Tw T* (\023\031\021\017 \n\024\020\031\021 \002\t\021\034 \r\024\r\035\036\004\036\ \027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036 \007\017\r\036\030\021\017\022\031)Tj 0 Tw (-)Tj 0.291 Tw T* (\035\016\030\027\024\005 \002\024\035\036\027\017, \023\024\220\021\024\ \n\031 \024\006\036\027\022\026 \n\036\021\026\002\024\035\024\n\026 \f\004\ \017)Tj 0 Tw (-)Tj 0.245 Tw T* (\021\026\036\021\f\016 \002\024\035\036\036 \021\024\004\027\024\005 \006\ \036\035\034\033 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 \220\021\024\005 )Tj 0 Tw T* (\r\026\017\n\024\f\r\016\017.)Tj 0.197 Tw T* (\225\030\036\007\017 \n\036\021\026\002\024\035\017\021\024\r \022\017\001\ \036\004\027\024\005 \n\017\022\030\024\002\017\024\021\t, \r\t\016\r\035\ \016)Tj 0 Tw (-)Tj 0.104 Tw T* (\036\n\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\004\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ )Tj 0 Tw (-)Tj 0.064 Tw T* [(\027\034\033 $\031\030\024\035\017\021\017\027\t \(U)15(rA$, \035\017\020\027\026\027\t, \020\017\023\023\031\030\026\021\), \027\ \026\017\002\024\035\036\036 )]TJ 0.31 Tw T* (\031\f\021\024\005\004\017\r\t\n\017 \016\r\035\016\033\021\f\016 \022\024\ \030\024\021\022\017\036 \032\017\030\027\t\036 \022\017\f\035\024\021\t\ , )Tj 0.103 Tw T* (\022\024\021\024\030\t\036 \r\t\030\026\002\026\021\t\r\026\033\021\f\016\ \023\030\026\022\021\017\004\036\f\022\017 \r\f\036\n\017 \024\f\027\024\ \r)Tj 0 Tw (-)Tj 0.307 Tw T* (\027\t\n\017 \f\036\n\036\005\f\021\r\026\n\017 \002\026\022\021\036\030\ \017\005, \027\026\f\036\035\016\033\013\017\b \021\024\035\f\021\031\033\ )Tj 0.194 Tw T* (\022\017\001\022\031. \204\024\027\024\f\026\b\026\030\017\007\t, \023\030\ \024\007\031\022\021\t \020\017\007\030\024\035\017\026 \031\020\035\036\ \r\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\007\024\r, \023\030\036\r\030\026\013\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\017\030\031\r\026\021 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \020\035\017\022\024\035\017\026 )Tj 0.185 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.892 0 Td [(\021\024\027\022\024\005 )0.5(\022\017\001\022\036 )0.5([36,37]. )]TJ /T1_2 1 Tf 0 Tw 9.92 0 Td [(Fir)-14(micutes)]TJ /T1_0 1 Tf 0.185 Tw [( )0.5($)]TJ /T1_2 1 Tf 0 Tw (Lachnospiraceae)Tj /T1_0 1 Tf ( )Tj -10.812 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 1.035 0 Td [(R)22(uminococcaceae)]TJ /T1_0 1 Tf 0.284 Tw ($ \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (Bacteroide)Tj /T1_0 1 Tf 0.284 Tw (s \023\030\036\024\002\030\026\031\033\021 \027\036)Tj 0 Tw (-)Tj 0.249 Tw -1.035 -1.218 Td (\023\036\030\036\r\026\030\017\r\026\036\n\t\036 \031\020\035\036\r\024\007\ \t, \021\026\022\017\036 \022\026\022 \023\017\013\036\r\t\036 \r\024)Tj 0 Tw (-)Tj 0.266 Tw T* (\035\024\022\027\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\024\021\022\017\036 \032\017\030\027\t\036 \022\017\f\035\024\ \021\t [38,39]. \200)Tj /Span<>> BDC ( )Tj EMC (\022\017)Tj 0 Tw (-)Tj 0.418 Tw T* (\001\036\004\027\024\005 \f\030\036\007\036 \022\024\030\024\021\022\024\ \006\036\023\024\004\027\t\036 \032\017\030\027\t\036 \022\017\f\035\024\ \021\t )Tj 0.155 Tw T* (\f\024\f\021\024\016\021 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\006\036\021\026\021\026, \023\030\024\023\017\024\027\026\021\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\002\031\021\017)Tj 0 Tw (-)Tj 0.094 Tw T* (\030\026\021\026, \022\024\021\024\030\t\036 \016\r\035\016\033\021\f\016\ \024\f\027\024\r\027\t\n\017 \026\027\017\024\027\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj 0.079 Tw T* (\f\021\024\005 \022\017\001\022\036 [40]. \025\024\030\024\021\022\024\006\ \036\023\024\004\027\t\036 \032\017\030\027\t\036 \022\017\f\035\024\021\ \t )Tj 0.278 Tw T* (\026\002\f\024\030\002\017\030\031\033\021\f\016 \022\024\035\024\027\024\ \006\017\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\024\r\016\021\f\016 \024\f\027\024\r)Tj 0 Tw (-)Tj 0.123 Tw T* [(\027\t\n \017\f\021\024\004\027\017\022\024\n \220\027\036\030\020\017\017\ \007\035\016 \220\023\017\021\036\035\017\026\035\034\027\t\b )0.5(\022\035\036\021\024\022 )]TJ 0.356 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 [35,41]. \025\024\030\024\ \021\022\024\006\036\023\024\004\027\t\036 \032\017\030\027\t\036 )Tj 0.185 Tw T* (\022\017\f\035\024\021\t \017\020\030\026\033\021 \026\013\017\021\027\031\ \033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\n \021\030\026\022\021\036 )Tj 0.54 Tw T* (\023\024\f\030\036\007\f\021\r\024\n \n\027\024\032\036\f\021\r\026 \n\036\ \b\026\027\017\n\024\r. \211\r\036\035\017\004\017\r\026\016 )Tj 0.297 Tw T* (\006\036\035\024\f\021\027\024\f\021\034 \f\035\017\017\f\021\024\020\024\ \002\026\030\034\036\030\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \f\036\022\030\036\006\017\017 )Tj 0.262 Tw 23.244 64.543 Td (\n\031\006\017\027\026 [42,43], \022\024\030\024\021\022\024\006\036\023\ \024\004\027\t\036 \032\017\030\027\t\036 \022\017\f\035\024\021\t )Tj 0.095 Tw T* (\017\027\007\031\006\017\030\031\033\021 \007\017\235\235\036\030\036\027\ \006\017\030\024\r\022\031 \n\024\027\024\006\017\021\024\r \022\017\001\ \036\004\027\017)Tj 0 Tw (-)Tj -0.018 Tw T* (\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\n\017\022\030\024\002\027\t\036 \n\026\022\030\024\235\026\ \020\017 [44] \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\007\036\030\032\017\r\026\033\021 )Tj 0.261 Tw T* (\020\024\n\036\024\f\021\026 \030\036\020\031\035\016\021\024\030\027\t\ \b \224-\022\035\036\021\024\022 [39,45], \004\021\024 \024\002\036)Tj 0 Tw (-)Tj 0.225 Tw T* (\f\023\036\004\017\r\026\036\021 \026\013\017\021\027\t\005 \220\235\235\ \036\022\021. \225\027\017\032\036\027\017\036 \r\t\007\036\035\036\027\017\ \016 )Tj 0.184 Tw T* (\022\024\030\024\021\022\024\006\036\023\024\004\027\t\b \032\017\030\027\ \t\b \022\017\f\035\024\021 \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\035\024\n \022\024\030\030\036\035\017)Tj 0 Tw (-)Tj 0.013 Tw 0 -1.218 TD (\030\031\036\021 \f\024 \f\027\017\032\036\027\017\036\n \002\031\021\017\ \030\026\021\023\030\024\007\031\006\017\030\031\033\013\017\b \002\026\022\ \021\036\030\017\005 )Tj 0.076 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017, \004\021\024 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\020\017\023\036)Tj 0 Tw (-)Tj -0.055 Tw T* (\030\024\022\f\017\020\036\027\026\006\017\017 \220\023\017\021\036\035\017\ \016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\n\031 \030\024\f\021\031 \023\024\ \021\036\027)Tj 0 Tw (-)Tj T* (\006\017\026\035\034\027\024 \023\026\021\024\020\036\027\027\t\b \023\030\ \024\021\036\024\002\026\022\021\036\030\017\005 [46].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 578.6938 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.3 Tw 10 0 0 10 303.3071 554.3378 Tm [(\200 )0.5(\024\f\027\024\r\036 )0.5(\030\026\r\017\021\017\016 )0.5(\007\017\r\036\030\021\017\022\031\035\017\021\026 )0.5(\035\036\032\026\021 )0.5(\r\024\f\023\026\035\017)]TJ 0 Tw (-)Tj 0.267 Tw T* [(\021\036\035\034\027\t\036 )0.6(\017\n\036\027\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.79 0 Td [(\f\021\036\027\022\036 )0.5(\007\017\r\036\030\021\017\022\031\035\026, )0.6(\026\f\f\024\006\017)]TJ 0 Tw (-)Tj 0.148 Tw -9.79 -1.218 Td (\017\030\024\r\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\036\n \007\026\r\035\036\027\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036 \007\017)Tj 0 Tw (-)Tj 0.06 Tw T* (\r\036\030\021\017\022\031\035\026. \224\026\022 \032\036 \r\024\027\017\ \022\026\036\021 \031\r\036\035\017\004\036\027\017\036 \026\022\021\017\ \r\027\024\f\021\017 )Tj -0.033 Tw T* (\021\031\004\027\t\b \022\035\036\021\024\022, \004\021\024 \r\t\t\r\026\ \036\021 \r\t\f\r\024\002\024\032\007\036\027\017\036 \023\030\024\021\036\ \026, )Tj 0.032 Tw T* [(\020\017\f\021\026\n\017\027\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.278 0 Td [(\f\036\030\024\021\024\027\017\027\026, )0.6(\r\t\t\r\026\033\013\017\b )0.5(\f\023\026\n )0.6(\020\035\026\007\022\024\005 )]TJ 0.039 Tw -5.278 -1.218 Td (\n\031\f\022\031\035\026\021\031\030\t \022\017\001\036\004\027\017\022\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\031\020\031\002\035\016\033\013\017\036 \021\036\004\036\027\017\036\ \026)Tj 0 Tw (-)Tj T* (\002\024\035\036\r\026\027\017\016 [4,47].)Tj 0.322 Tw T* [(\215\024 \n\027\036\027\017\033 Byndl)30.1(oss M.X. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \f\027\017\032\036\027\017\036 \023\024)Tj 0 Tw (-)Tj 0.337 Tw T* (\023\031\035\016\006\017\017 \002\026\022\021\036\030\017\005, \023\030\024\ \007\031\006\017\030\031\033\013\017\b \002\031\021\017\030\026\021, \r\036\ \007\036\021 )Tj 0.07 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\033 \f\017\020\027\026\035\024\r, \023\ \036\030\036\007\026\r\026\036\n\t\b \004\036\030\036 \220\023\017\021\036\ )Tj 0 Tw (-)Tj 0.076 Tw T* (\035\017\026\035\034\027\t\036 \002\031\021\017\030\026\021\027\t\036 \020\ \026\n\n\026-\030\036\006\036\023\021\024\030\t, \022\024\021\024\030\t\036\ \026\022)Tj 0 Tw (-)Tj 0.093 Tw T* [(\021\017\r\017\030\031\033\021\f\016 )0.6(\023\030\024\035\017\235\036\030\026\021\024\030\026\n\017 )0.5(\023\036\030\024\022\f\017\f\024\n )0.6($PP)25(AR-y$. )]TJ -0.015 Tw T* [(\237\021\024 \n\024\032\036\021 )0.5(\023\030\017\r\036\f\021\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\r\t\001\036\027\027\024\n\031 )0.5(\031\030\024\r\027\033 \022\017\f\035\024\030\024)]TJ 0 Tw (-)Tj -0.022 Tw T* (\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\033 \002\026\035\026\027\f\026 \n\036\032\ \007\031 \235\026\022\031\035\034\021\026)Tj 0 Tw (-)Tj 0.065 Tw T* (\021\017\r\027\t\n\017 \026\220\030\024\002\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\220\030\024\002\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\022\030\024\002\017\024\n\036, \004\021\024, )Tj -0.027 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \023\030\017\r\024\007\017\021\ \022)Tj /Span<>> BDC ( )Tj EMC (\030\024\f\021\031 \023\024\021\036\027\006\017\026\035\034\027\024 \023\ \026\021\024)Tj 0 Tw (-)Tj -0.039 Tw T* [(\020\036\027\027\t\b \023\030\024\021\036\024\002\026\022\021\036\030\017\ \005 [48]. \025\030\024\n\036 \021\024\020\024, Goncal)30.1(ves)]TJ /Span<>> BDC ( )Tj EMC (P. )Tj 0.239 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\024\022\026\026\035\017, \004\021\024 \f\027\017\ \032\036\027\017\036 \f\017\027\021\036\026 \002\031\021\017\030\026\021\ \026 )Tj 0.183 Tw T* [(\002\t\035\024 )0.5(\f\r\016\026\027\024 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 7.064 0 Td [(\031\r\036\035\017\004\036\027\017\036\n )0.6(\022\024\035\017\004\036\f\021\r\026 )0.5(\017\n\n\031\027\027\t\b )]TJ ET q 303.307 122.633 221.102 179.57 re W n q /GS0 gs 221.1023475 0 0 179.570636 303.3070555 122.632666 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.049 Tw 9 0 0 9 303.3071 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \207\n\037\024\035\022\016 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[32]. )Tj 0.222 Tw T* (\025\030\024\n\036 \021\024\020\024, MMP-1, MMP-2, MMP-3 \017)Tj /Span<>> BDC ( )Tj EMC (TIMP-1 \017\n\036\035\017 )Tj -0.041 Tw 23.244 6.089 Td (\002\024\035\036\036 \r\t\f\024\022\031\033 \030\026\f\023\030\024\f\021\ \030\026\027\036\027\027\024\f\021\034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.27 Tw T* (\035\024\032\027\036\027\027\024\005 \007\017\r\036\030\021\017\022\031\035\ \016\030\027\024\005 \002\024\035\036\027\034\033 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.116 Tw T* (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\024\005 \022\024\027\021\030\024\035\016 [33,34]. M\ imur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC (T. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.027 Tw T* (\r\t\016\f\027\017\035\017, \004\021\024 \220\022\f\023\030\036\f\f\017\016\ TIMP-1 \017)Tj /Span<>> BDC ( )Tj EMC (TIMP-2 \002\t\035\026 \027\026)Tj 0 Tw (-)Tj 0.01 Tw T* (\004\017\021\036\035\034\027\024 \r\t\001\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\b \235\024\030\n\026\b \007\017\r\036\ \030\021\017\022\031)Tj 0 Tw (-)Tj 0.136 Tw T* [(\035\016\030\027\024\005 )0.5(\002\024\035\036\027\017, )0.6(\004\021\024 )0.5(\021\030\036\002\031\036\021 )0.5(\007\026\035\034\027\036\005\001\036\020\024 )0.6(\017\031\004\036\027\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\027\022\030\020\022\016 \b\022\021\033\034\025\022\034\035\032 \020\ \037)Tj /Span<>> BDC ( )Tj EMC [(\035\016\n\016\020\022\016 \005\022\036\016\033\035\022\021\023\027\030\033\ \020\034\t \025\034\027\016\031\020)0.5(\022 \036)]TJ /Span<>> BDC ( )Tj EMC (\023\024\027\034\036\022\030\001 \021\027\022\020\022\n\016\024\021\034\013\ \034 \022\024\024\027\016\005\034\036\037\020\022\030)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( T)-6.4(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(ef)-42.4(f)-13.4(e)-10.9(c)-32.4(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.4(i)-1.8(c)-8.2(r)-2(o)-2.3(b)-1.1(i)-1.3(o)-2.9(t)-2(a o)-4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.9(o)-3.4(u)1.6(r)-14.9(s)0.5(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-2.9(i)-2.9(v)2.3(e)-6(r)-41.9(t)-29.1(i)-1.8(c)-0.6(u)-1.6(l)-1(a)-4.2(r d)-3(i)6.6(s)0.5(e)-7.5(a)-7.2(s)0.5(e i)4(n a)]TJ /Span<>> BDC ( )Tj EMC [(c)-1.1(li)3.9(n)1.7(i)-1.7(c)3.2(a)-4.5(l s)-14.8(t)-1.1(u)-5.9(d)-7.2(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 116.4705 715.181 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 144.8169 715.181 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 295.0532 715.181 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 673.3005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 116.4705 703.7117 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 673.3005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 144.8169 703.7117 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 673.3005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 295.0532 703.7117 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 673.3005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 673.3005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 673.0505 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 633.0392 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 116.4705 673.0505 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 633.0392 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 144.8169 673.0505 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 633.0392 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 295.0532 673.0505 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 633.0392 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 633.0392 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 632.7892 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 602.3779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 116.4705 632.7892 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 602.3779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 144.8169 632.7892 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 602.3779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 295.0532 632.7892 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 602.3779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 602.3779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 602.1279 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 533.3167 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 116.4705 602.1279 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 533.3167 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 144.8169 602.1279 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 533.3167 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 295.0532 602.1279 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 533.3167 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 496.313 533.3167 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 42.5197 533.0667 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 464.2553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 116.4705 533.0667 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 464.2553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 144.8169 533.0667 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 464.2553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 295.0532 533.0667 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 464.2553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 496.313 464.2553 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 42.5197 464.0053 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 414.394 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 116.4705 464.0053 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 414.394 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 144.8169 464.0053 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 414.394 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 295.0532 464.0053 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 414.394 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 496.313 414.394 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 42.5197 414.144 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 364.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 116.4705 414.144 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 364.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 144.8169 414.144 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 364.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 295.0532 414.144 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 364.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 496.313 364.5328 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 42.5197 364.2828 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 324.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 116.4705 364.2828 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 324.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 144.8169 364.2828 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 324.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 295.0532 364.2828 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 324.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 324.2715 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 324.0215 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 255.2102 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 116.4705 324.0215 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 255.2102 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 144.8169 324.0215 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 255.2102 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 295.0532 324.0215 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 255.2102 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 496.313 255.2102 cm 0 0 m 0 68.561 l S Q q 1 0 0 1 42.5197 254.9602 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 224.5489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 116.4705 254.9602 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 224.5489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 144.8169 254.9602 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 224.5489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 295.0532 254.9602 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 224.5489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 224.5489 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 224.2989 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 203.4876 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 116.4705 224.2989 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 203.4876 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 144.8169 224.2989 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 203.4876 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 295.0532 224.2989 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 203.4876 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 203.4876 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 203.2376 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 42.7697 163.2263 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 116.4705 203.2376 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 116.4705 163.2263 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 144.8169 203.2376 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 144.8169 163.2263 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 295.0532 203.2376 cm 0 0 m 201.51 0 l S Q q 1 0 0 1 295.0532 163.2263 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 163.2263 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 162.9763 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 116.4705 162.9763 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 144.8169 162.9763 cm 0 0 m 150.236 0 l S Q q 1 0 0 1 295.0532 162.9763 cm 0 0 m 201.51 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 66.4762 706.5463 Tm (\032\003\002\006\013)Tj 7.257 0 Td (\027\002\240)Tj 4.512 0 Td (\034\213\214\r\b\r\b\t\235 )Tj /Span<>> BDC ( )Tj EMC (\217\002\217\003\004\r \214\t\220\006\002\206\t\002\003\013)Tj 24.594 0 Td (\026\f\t\235\b\t\r \b\004)Tj /Span<>> BDC ( )Tj EMC (\212\004\003\002\n\r\b\r\213)Tj /T1_1 1 Tf -38.972 -1.433 Td (Scarpignato C. et )Tj 0 -1.2 TD (al. [23])Tj 9.63 1.2 Td (2017)Tj 3.126 0 Td (\225\027\017\032\036\027\017\036 \004\017\f\035\026 \002\031\021\017\030\ \026\021-\023\030\024\007\031\006\017\030\031\033\013\017\b )Tj T* (\002\026\022\021\036\030\017\005 $)Tj /T1_3 1 Tf (Prevotella, Firmicutes)Tj /T1_1 1 Tf ($)Tj 18.78 1.2 Td (\203\026\030\031\001\036\027\017\036 \021\030\024\235\017\022\017 \220\023\ \017\021\036\035\017\024\006\017\021\024\r)Tj T* (\215\024\r\t\001\036\027\017\036 \023\030\024\027\017\006\026\036\n\024\f\ \021\017)Tj 0 -1.2 TD (\230\214-10)Tj /C2_0 1 Tf <0070>Tj /T1_1 1 Tf (, NF-\230\214-12)Tj /C2_0 1 Tf <0070>Tj /T1_1 1 Tf (, \230\205-\265)Tj /C2_0 1 Tf <006E>Tj /T1_1 1 Tf (, \205\203\210-a)Tj /C2_0 1 Tf <006E>Tj /T1_1 1 Tf (, \230\214-8)Tj /C2_0 1 Tf <006E>Tj /T1_1 1 Tf -31.535 -1.433 Td (Schieffer K.M. et al. )Tj 0 -1.2 TD ([24])Tj 9.63 1.2 Td (2017)Tj 3.126 0 Td (\211\r\036\035\017\004\036\027\017\036 \022\024\035\017\004\036\f\021\r\026\ Microbacteriaceae )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC (Basidiomycota \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\035\034\027\024\005 )Tj T* (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \021\022\026\027\ \017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\035\036\020\026\033\013\036\005 \021\022\026\027\034\033)Tj 18.78 3.6 Td (\215\024\r\t\001\036\027\027\024\036 \n\027\024\020\024\024\002\030\026\ \017\036 \n\036\021\026\027\024\024\024\002\030\026\031\033\013\017\b )Tj T* (\002\026\022\021\036\030\017\005 \n\024\032\036\021 \002\t\021\034 \f\r\016\ \026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\016\n\017 )Tj T* (\n\024\021\024\030\017\022\017 \022\017\001\036\004\027\017\022\026, \022\ \024\021\024\030\t\036 \f\023\024\f\024\002\f\021\r\031\033\021 \030\026\ \r\017\021\017\033 )Tj T* (\007\017\r\036\030\021\017\022\031\035\024\r.)Tj -31.535 -1.433 Td (Kvasnovsky C.L et )Tj T* (al. [17])Tj 9.63 1.2 Td (2018)Tj 3.126 0 Td (\225\027\017\032\036\027\017\036 \004\017\f\035\026 \002\031\021\017\030\ \026\021-\023\030\024\007\031\006\017\030\031\033\013\017\b )Tj T* (\002\026\022\021\036\030\017\005 $)Tj /T1_3 1 Tf (Prevotella, Firmicutes)Tj /T1_1 1 Tf ($.)Tj 18.78 1.2 Td (\203\026\030\031\001\036\027\017\036 \030\036\020\031\035\016\006\017\017\ Treg \035\017\n\235\024\006\017\021\024\r.)Tj T* (\212\017\f\021\030\024\235\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\n\024\021\024\030\017\022\026 \022\017\001\036\004\027\024\005\ \f\021\036\027\022\017.)Tj T* (\203\026\030\031\001\036\027\017\036 \f\017\027\021\036\026 \021\030\017\ \023\021\024\235\026\027\026, \f\036\030\024\021\024\027\017\027\026.)Tj -31.535 -1.433 Td (Daniels L. et al. [18])Tj 9.63 0 Td (2014)Tj 3.126 0 Td (\215\024\r\t\001\036\027\017\036 \022\035\026\f\021\036\030\026 Proteoba\ cteria, )Tj T* (Enterobacteriaceae)Tj 18.78 1.2 Td (\230\027\007\031\022\006\017\016 \f\017\027\021\036\026 \023\030\024\r\024\ \f\023\026\035\017\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\ \r $\230\214-6, )Tj T* (\230\214-12, \230\214-23, \230\214-17, \205\203\210-a$.)Tj T* (\215\024\r\t\001\036\027\017\036 \022\024\035\017\002\026\022\021\017\027\ \026 $\020\036\027\024\021\024\022\f\017\004\027\t\005 \n\036\021\026\002\ \024\035\017\021, )Tj T* (\r\t\t\r\026\033\013\017\005 \023\024\r\030\036\032\007\036\027\017\036\ \212\203\025$.)Tj T* (\230\027\r\026\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036 \220\023\017\021\036\035\017\026\ \035\034\027\t\b \022\035\036\021\024\022.)Tj T* (\230\027\007\031\022\006\017\016 \f\017\027\021\036\026 \021\026\b\017\022\ \017\027\017\027\026 1, \007\017\f\n\024\021\024\030\017\022\026 \031\004\ \026\f\021\022\024\r )Tj T* (\021\024\035\f\021\024\005 \022\017\001\022\017.)Tj -31.535 -1.433 Td (Linninge C. et al. )Tj 0 -1.2 TD ([19])Tj 9.63 1.2 Td (2018)Tj 3.126 0 Td (\215\024\r\t\001\036\027\017\036 Proteobacteria \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\f\021\r\026 )Tj T* (Comamonadaceae \031)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \007\017\r\036\030\021\017\022\031\035\017\021\026\ )Tj 18.78 1.2 Td (\230\027\007\031\022\006\017\016 \f\017\027\021\036\026 \023\030\024\r\024\ \f\023\026\035\017\021\036\035\034\027\t\b \006\017\021\024\022\017\027\024\ \r $\230\214-6, )Tj T* (\230\214-12, \230\214-23, \230\214-17, \205\203\210-a$.)Tj 0 -1.2 TD (\230\027\r\026\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036 \220\023\017\021\036\035\017\026\ \035\034\027\t\b \022\035\036\021\024\022.)Tj 0 -1.2 TD (\203\026\030\031\001\036\027\017\036 \030\036\020\031\035\016\006\017\017\ Treg \035\017\n\235\024\006\017\021\024\r.)Tj T* (\215\024\r\t\001\036\027\017\036 \023\030\024\027\017\006\026\036\n\024\f\ \021\017 \022\017\001\036\004\027\024\005 \f\021\036\027\022\017.)Tj T* (\230\027\007\031\022\006\017\016 \f\017\027\021\036\026 \021\026\b\017\022\ \017\027\017\027\026 1, \007\017\f\n\024\021\024\030\017\022\026 \031\004\ \026\f\021\022\024\r )Tj T* (\021\024\035\f\021\024\005 \022\017\001\022\017.)Tj -31.535 -1.433 Td (Jones R.B. et al. [25])Tj 9.63 0 Td (2018)Tj 3.126 0 Td (\211\n\036\027\034\001\036\027\017\036 Lachnospiracea, Ruminococcus )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC (Faecalibacterium \017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\036 )Tj T* (\022\024\035\017\004\036\f\021\r\026 Fusobacteria, Prevotella )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC (Paraprevotella \031)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \007\017\r\036\030\021\017\022\031\035\017\021\026\ )Tj T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\024\005\ )Tj 18.78 4.8 Td (\200\t\f\r\024\002\024\032\007\036\027\017\036 \035\017\023\024\023\024\035\ \017\f\026\b\026\030\017\007\024\r Fusobacteria, )Tj T* (Prevotella.)Tj T* (\215\024\r\t\001\036\027\017\036 \023\030\024\027\017\006\026\036\n\024\f\ \021\017 \022\017\001\036\004\027\024\005 \f\021\036\027\022\017.)Tj T* (\204\036\021\026\002\024\035\017\004\036\f\022\026\016 \220\027\007\024\021\ \024\022\f\036\n\017\016.)Tj -31.535 -2.633 Td (O\241Grady M.J. et al. )Tj T* ([26])Tj 9.63 1.2 Td (2022)Tj 3.126 0 Td (\211\r\036\035\017\004\036\027\017\036 \023\030\036\007\f\021\026\r\017\021\ \036\035\036\005 )Tj T* (\030\024\007\024\r )Tj /T1_3 1 Tf (Prevotella, Fusicatenibacter )Tj T* (\022)Tj /Span<>> BDC ( )Tj EMC (Faecalibacterium )Tj /T1_1 1 Tf (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\024\005 )Tj T* (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\034\033 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\f\035\024\032\027\036\027\027\024\005)Tj 18.78 4.8 Td (\203\026\030\031\001\036\027\017\036 \021\030\024\235\017\022\017 \220\023\ \017\021\036\035\017\024\006\017\021\024\r.)Tj T* (\215\024\r\t\001\036\027\017\036 \023\030\024\027\017\006\026\036\n\024\f\ \021\017.)Tj T* (\203\026\030\031\001\036\027\017\036 \030\036\020\031\035\016\006\017\017\ Treg \035\017\n\235\024\006\017\021\024\r.)Tj T* (\230\027\r\026\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036 \220\023\017\021\036\035\017\026\ \035\034\027\t\b \022\035\036\021\024\022.)Tj -31.535 -2.633 Td (Lopetuso L. et al. )Tj T* ([27])Tj 9.63 1.2 Td (2016)Tj 3.126 0 Td (\211\r\036\035\017\004\036\027\017\036 Akkermansia muciniphila)Tj 18.78 0 Td (\230\f\021\024\027\004\036\027\017\036 \f\035\024\016 \f\035\017\017.)Tj T* (\215\024\r\t\001\036\027\017\036 \023\030\024\027\017\006\026\036\n\024\f\ \021\017 \022\017\001\036\004\027\024\005 \f\021\036\027\022\017.)Tj T* (\210\023\024\f\030\036\007\024\r\026\027\027\026\016 \026\022\021\017\r\026\ \006\017\016 TOLL \023\024\007\024\002\027\t\b \030\036\006\036\023\021\024\ \030\024\r.)Tj T* (\230\027\007\031\022\006\017\016 \r\024\f\023\026\035\017\021\036\035\034\ \027\024\020\024 \022\026\f\022\026\007\026.)Tj -31.535 -1.433 Td (Barbaro M.R. et al. )Tj T* ([14])Tj 9.63 1.2 Td (2017)Tj 3.126 0 Td (\225\027\017\032\036\027\017\036 Fusobacterium \017)Tj /Span<>> BDC ( )Tj EMC (Lactobacillaceae)Tj 18.78 0 Td (\225\027\017\032\036\027\017\036 \024\023\024\f\030\036\007\024\r\026\027\ \027\024\005 toll-\023\024\007\024\002\027\t\n \030\036\006\036\023\021\024\ \030\024\n )Tj T* (2)Tj /Span<>> BDC ( )Tj EMC ($TLR2$-\026\r\017\f\017\n\024\005 \f\021\017\n\031\035\016\006\017\017\ \017 \f\036\022\030\036\006\017\017 TNF-\256.)Tj 0 -1.2 TD (\211\n\036\027\034\001\036\027\017\036 AHR \017)Tj /Span<>> BDC ( )Tj EMC (Nrf2, \023\024\r\t\001\036\027\017\036 \023\030\024\027\017\006\026\036\n\ \024\f\021\017 )Tj 0 -1.2 TD (\022\017\001\036\004\027\024\020\024 \002\026\030\034\036\030\026 \017-\ \026 \024\f\035\026\002\035\036\027\017\016 \023\035\024\021\027\t\b \022\ \024\027\021\026\022\021\024\r.)Tj 0 -1.2 TD (\203\026\030\031\001\036\027\017\036 \004\031\r\f\021\r\026 \022\r\024\030\ \031\n\026.)Tj T* (\211\n\036\027\034\001\036\027\017\036 \220\022\f\023\030\036\f\f\017\017\ \n\031\006\017\027\024\r\t\b \002\036\035\022\024\r $Muc2$, )Tj T* (\007\036\020\030\026\007\026\006\017\016 \f\035\017\017.)Tj -31.535 -1.433 Td (Schieffer K.M. et al. )Tj T* ([28])Tj 9.63 1.2 Td (2018)Tj 3.126 0 Td (\215\024\r\t\001\036\027\017\036 \022\024\027\006\036\027\021\030\026\006\ \017\017 )Tj T* (\006\017\021\024\n\036\020\026\035\024\r\017\030\031\f\026)Tj 18.78 1.2 Td (\200\t\030\026\032\036\027\027\026\016 \220\022\f\023\030\036\f\f\017\016\ \020\036\027\024\r, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\r\017\030\031\f\027\t\n )Tj T* (\024\021\r\036\021\024\n, \026\022\021\017\r\017\030\031\036\n\t\b \017\027\ \021\036\030\235\036\030\024\027\024\n.)Tj T* (\215\036\030\036\022\030\036\f\021\027\026\016 \030\036\026\022\006\017\016\ , \017\027\007\031\022\006\017\016 \r\024\f\023\026\035\036\027\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036.)Tj -31.535 -1.433 Td (Van Rossen T.M. et )Tj 0 -1.2 TD (al. [11])Tj 9.63 1.2 Td (2021)Tj 3.126 0 Td (\203\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \030\026\035\017\004\ \017\005 \n\036\032\007\031 )Tj T* (\022\024\027\021\030\024\035\034\027\t\n\017 \020\030\031\023\023\026\n\017\ )Tj 18.78 1.2 Td (\203\036 \031\f\021\026\027\024\r\035\036\027\024.)Tj -31.535 -2.633 Td (Naamah L. et al. 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\r\t\016\r\035\036\027\024 )Tj -0.022 Tw 0 -1.218 TD (\027\026\004\017\021\036\035\034\027\024\036 \031\r\036\035\017\004\036\ \027\017\036 \220\027\021\036\030\024\002\026\022\021\036\030\017\005 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (35 \023\030\036\007\f\021\026\r\017\021\036\035\016\n\017 \022\024\027\021\ \030\024\035\034\027\024\005 \020\030\031\023\023\t [19].)Tj 0.178 Tw T* [(\200 \b\024\007\036 \017\f\f\035\036\007\024\r\026\027\017\016 O\241G)20(r)-33(ad)17(y M.J. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.168 Tw T* (\023\024\035\034\024\r\026\027\017\017 \f\036\022\r\036\027\017\030\024\ \r\026\027\017\016 16S \030\217\203\025 \030\036\022\021\026\035\034\027\ \t\b )Tj 0.32 Tw T* (\n\026\022\024\r \002\t\035\024 \024\002\027\026\030\031\032\036\027\024\ \001\036\f\021\034 \030\026\035\017\004\027\t\b \030\024\007\024\r )Tj 0.391 Tw T* (\002\026\022\021\036\030\017\005, \022\024\021\024\030\t\036 \004\026\013\ \036 \r\f\021\030\036\004\026\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030)Tj 0 Tw (-)Tj 0.464 Tw T* (\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\017. \225\ \030\036\007\017 \027\017\b \002\t\035\017 \r\t\016\r\035\036\027\t )Tj 0.511 Tw T* [(\030\024\007\t, \017\r\036\f\021\027\t\036 \f\r\024\036\005 \023\026\021\ \024\020\036\027\027\024\005 )0.5(\026\022\021\017\r\027\024\f\021\034\033, )]TJ 0.542 Tw T* [(\021\026\022\017\036 \022\026\022 F)10(usoba)-17(c)-16(ter)-37(ia, P)35.1(r)-24(evo)17(tell)-16(a, P)40(ar)-33(ap)25(r)-24(evo)17(tell)-15.9(a )]TJ 0.219 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(Rumino)-16(co)-16(ccus. \224\026\022\032\036 \r)]TJ /Span<>> BDC ( )Tj EMC (\b\024\007\036 \017\f\f\035\036\007\024\r\026\027\017\016 \002\t\035\017\ )Tj 0.149 Tw T* (\024\002\027\026\030\031\032\036\027\t \030\026\035\017\004\017\016 \n\036\ \032\007\031 \027\036\024\f\035\024\032\027\036\027\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.601 Tw T* (\035\024\032\027\036\027\027\t\n \021\036\004\036\027\017\036\n \007\017\ \r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017. )Tj 0.347 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 2.2 0 Td [(\007\026\035\034\027\036\005\001\036\n )0.6(\026\027\026\035\017\036 )0.5(\023\024\007\020\030\031\023\023 )0.6(\002\t\035\024 )0.5(\024\002\027\026\030\031)]TJ 0 Tw (-)Tj 0.099 Tw -2.2 -1.218 Td (\032\036\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\n \021\036\004\036\027\017\036\n \007\ \017\r\036\030)Tj 0 Tw (-)Tj 0.524 Tw T* [(\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\017 )0.5(\002\t\035\024 \r\t\016\r\035\036\027\024 \031\r\036\035\017\004\036\027\ \017\036 )]TJ 0.505 Tw T* [(\023\030\036\007\f\021\026\r\017\021\036\035\036\005 \030\024\007\024\r \ P)35(r)-24(evo)17(tell)-16(a, F)10(usica)15(teniba)-17(c)-16(ter )]TJ 0.145 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(F)20(aecal)-31(iba)-17(c)-16(ter)-36.9(ium \023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \002\036 \024\f)Tj 0 Tw (-)Tj T* (\035\024\032\027\036\027\017\005 [20].)Tj 0.509 Tw T* (\200 \b\024\007\036 \027\036\002\024\035\034\001\024\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016, \023\030\024\r\036\007\036\027\027\024\020\ \024 )Tj -0.012 Tw T* (Humes D.J., \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\026\021\017\004\036\f\022\017 \027\036\024\f\035\024\ \032)Tj 0 Tw (-)Tj -0.06 Tw T* (\027\036\027\027\024\005 \007\017\r\036\030\021\017\022\031\035\016\030\027\ \024\005 \002\024\035\036\027\034\033 \002\t\035\024 \024\002\027\026\030\ \031\032\036\027\024 )Tj 0.153 Tw T* (\031\r\036\035\017\004\036\027\017\036 \031\030\024\r\027\016 \220\022\f\ \023\030\036\f\f\017\017 \023\030\024\r\024\f\023\026\035\017\021\036\035\ \034\027\024\020\024 )Tj 0.289 Tw T* (\006\017\021\024\022\017\027\026 \205\203\210 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\023\036\023\021\017\007\027\024\020\024 \030\036\006\ \036\023\021\024\030\026 NK1, )Tj 0.137 Tw T* (\017\r\036\f\021\027\024\020\024 \022\026\022 \021\026\b\017\022\017\027\ \017\027 1. \237\021\024\021 \030\036\031\035\034\021\026\021 \004\026\f\ \021\017\004)Tj 0 Tw (-)Tj 0.221 Tw T* (\027\024 \024\002\255\016\f\027\016\036\021, \023\024\004\036\n\031 \r\024\ \f\023\026\035\036\027\017\036, \017\n\n\031\027\027\t\005 \024\021\r\036\ \021 )Tj 0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\036 \031\030\024\r\027\016 \021\026\b\ \017\022\017\027\017\027\024\r \n\024\020\031\021 \f\023\024\f\024\002\f\ \021\r\024)Tj 0 Tw (-)Tj -0.004 Tw T* (\r\026\021\034 \030\026\r\017\021\017\033 \r\t\030\026\032\036\027\027\t\ \b \022\035\017\027\017\004\036\f\022\017\b \023\030\024\016\r\035\036\027\ \017\005 )Tj 0.132 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\f)Tj 0 Tw (-)Tj T* (\f\017\n\023\021\024\n\027\t\n\017 \235\024\030\n\026\n\017 [4, 21].)Tj 0.075 Tw T* [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 S)-24(chief)-55.9(fer K. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\017 \023\024\022\026\026\027\t )Tj 0.039 Tw T* (\030\026\035\017\004\027\t\036 \031\030\024\r\027\017 \220\022\f\023\030\ \036\f\f\017\017 \020\036\027\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \030\026)Tj 0 Tw (-)Tj 0.203 Tw T* [(\r\017\021\017\016 )0.5(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024\035\036\027\017 \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC 20.821 0 Td (\024\f)Tj 0 Tw (-)Tj -0.016 Tw -20.821 -1.218 Td (\035\024\032\027\036\027\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \024\f\035\024\032\027\036\027\027\t\n\017 \235\024\030\n\026\n\ \017 \026\002\024\035\036\r\026)Tj 0 Tw (-)Tj 0.061 Tw T* [(\027\017\016. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024\035\036\027\034\033 )0.5(\002\t\035\026 )]TJ 0.133 Tw T* [(\023\024\007\021\r\036\030\032\007\036\027\026 \002\024\035\036\036 \r\t\ \030\026\032\036\027\027\026\016 )0.5(\220\022\f\023\030\036\f\f\017\016 \020\036\027\024\r, )]TJ 0.136 Tw T* (\f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\r\017\030\031\f\027\t\n \024\021\r\036\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\017\030\031\036\n\t\b \017\027)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\036\030\235\036\030\024\027\024\n. \025\030\024\n\036 \021\024\020\024\ , \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \023\026\006\017\036\027\021\024\ \r )Tj 0.172 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.841 0 Td [(\030\026\027\027\017\n )0.6(\027\026\004\026\035\024\n )0.5(\026\002\024\035\036\r\026\027\017\016 )0.6(\027\026\002\035\033\007\026\035\026\f\034 )0.5(\023\024\r\t)]TJ 0 Tw (-)Tj 0.208 Tw -0.841 -1.218 Td (\001\036\027\027\026\016 \220\022\f\023\030\036\f\f\017\016 \020\036\027\ \024\r, \031\004\026\f\021\r\031\033\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024)Tj 0 Tw (-)Tj 0.449 Tw T* (\r\017\030\031\f\027\024\005 \021\036\030\026\023\017\017 [22]. \224\026\ \022\017\n \024\002\030\026\024\n, \r\024\f\023\030\017)Tj 0 Tw (-)Tj 0.39 Tw T* [(\017\n\004\017\r\024\f\021\034 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 6.014 0 Td [(\r\017\030\031\f\027\t\n )0.6(\023\026\021\024\020\036\027\026\n )0.5(\n\024\032\036\021 )0.5(\f\035\031\032\017\021\034 )]TJ 0.197 Tw 17.23 64.543 Td [(\024\002\255\016\f\027\036\027\017\036\n )0.5(\021\024\020\024, \023\024\004\036\n\031 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\027\036\022\024\021\024\030\t\b )0.5(\035\033\007\036\005 )0.5(\030\026)]TJ 0 Tw (-)Tj 0.354 Tw T* [(\r\017\r\026\036\021\f\016 )0.6(\007\017\r\036\030\021\017\022\031\035\017\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\036\036 )0.5(\030\026\027\027\036\n )0.5(\r\024\030\026\f\021\036. )]TJ 0.241 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \020\030\031\023\023\t \023\026\006\017\036\027\ \021\024\r \021\026\022\032\036 \002\t\035\024 \r\t\016\r\035\036\027\024\ )Tj -0.02 Tw T* (\023\030\017\f\031\021\f\021\r\017\036 \006\017\021\024\n\036\020\026\035\ \024\r\017\030\031\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \021\024\035\f\021\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.382 Tw T* (\022\017, \023\024\030\026\032\036\027\027\024\005 \007\017\r\036\030\021\ \017\022\031\035\016\030\027\024\005 \002\024\035\036\027\034\033. \037\ \204\200 )Tj 0.085 Tw T* (\017\027\235\036\022\006\017\016 \017\n\036\036\021 \007\024\022\026\026\ \027\027\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\031\020\031\002\035\036\027\017\017 \021\036)Tj 0 Tw (-)Tj 0.201 Tw 0 -1.218 TD (\004\036\027\017\016 \002\024\035\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \002\024\035\034\027\t\b \r\024\f\023\026\035\017\ \021\036\035\034\027\t\n\017 )Tj 0.312 Tw 0 -1.218 TD (\026\002\024\035\036\r\026\027\017\016\n\017 \022\017\001\036\004\027\017\ \022\026 [22]. \237\021\017 \007\026\027\027\t\036 \007\026\033\021 )Tj -0.014 Tw T* [(\024\f\027\024\r\026\027\017\016 )0.5(\023\030\036\007\023\024\035\026\020\026\021\034, \004\021\024 )0.5(\r\017\030\031\f\027\t\036 \004\026\f\021\017\006\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\017\n)Tj 0 Tw (-)Tj 0.161 Tw T* (\n\031\027\027\t\005 \024\021\r\036\021 \b\024\016\017\027\026 \n\024\020\ \031\021 \f\023\024\f\024\002\f\021\r\024\r\026\021\034 \030\026\r\017)Tj 0 Tw (-)Tj T* (\021\017\033 \007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \ \002\024\035\036\027\017.)Tj 0.081 Tw T* (\204\036\b\026\027\017\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \r\035\017\016\027\017\016 \n\017\022\030\024\002\017\ \024\021\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004)Tj 0 Tw (-)Tj 0.401 Tw 0 -1.218 TD [(\027\t\036 \r\036\027\034\016 \023\026\021\024\020\036\027\036\026 \007\ \017\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024\035\036\027\017 )]TJ 0 Tw 0 -1.218 TD (\023\030\036\007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 1.)Tj -0.044 Tw 0 -1.218 TD [(\230\n\036\027\036\027\017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.421 0 Td [(\f\024\f\021\026\r\036 )0.5(\n\017\022\030\024\002\017\024\021\t )0.6(\024\022\026\t\r\026\033\021 )0.5(\r\035\017\016\027\017\036 )]TJ 0.135 Tw -5.421 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \007\ \017\r\036\030\021\017\022\031\035\017\021\026, \r\024\027\017\022\027\024\ \r\036)Tj 0 Tw (-)Tj 0.219 Tw T* (\027\017\036 \024\f\035\024\032\027\036\027\027\t\b \235\024\030\n \007\017\ \r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017. )Tj 0.203 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\n\017 \235\024\030\n\026\n\017 \007\ \017\r\036\030\021\017\022\031)Tj 0 Tw (-)Tj 0.406 Tw T* [(\035\016\030\027\024\005 \002\024\035\036\027\017, )0.5(\f\024\020\035\026\f\027\024 \023\030\024\r\036\007\036\027\027\t\n \017\ \f\f\035\036\007\024)]TJ 0 Tw (-)Tj 0.294 Tw T* (\r\026\027\017\016\n, \024\021\n\036\004\026\036\021\f\016 \031\r\036\035\ \017\004\036\027\017\036 \022\024\035\017\004\036\f\021\r\026 \022\035\036\ \021\024\022 )Tj 0.034 Tw T* (\215\026\027\036\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\030\024\235\026\020\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\026\004\017\021\036\035\034\027\t\036 \017\n\ \036\027\036)Tj 0 Tw (-)Tj -0.006 Tw T* [(\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\f\021\026\r\036 \n\017\022\030\024\002\017\024\021\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\031\r\036\035\017\004\036\027\017\036\n )0.5(\030\026\027\024\024\002\030\026)]TJ 0 Tw (-)Tj T* (\017\016 \r\017\007\024\r \002\026\022\021\036\030\017\005, \030\026\035\ \026\020\026\033\013\017\b \f\035\017\034 [15].)Tj 0.059 Tw T* (\211\r\036\035\017\004\036\027\017\036 \r\t\030\026\032\036\027\027\024\f\ \021\017 \r\024\f\023\026\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017)Tj 0 Tw (-)Tj 0.18 Tw T* [(\022\031\035\016\030\027\024\005 )0.6(\002\024\035\036\027\017 )0.5(\026\f\f\024\006\017\017\030\024\r\026\027\024 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 15.706 0 Td [(\002\024\035\036\036 )0.5(\r\t\f\024\022\017\n )]TJ 0.608 Tw -15.706 -1.218 Td (\030\024\007\024\r\t\n \030\026\027\024\024\002\030\026\017\036\n \235\ \036\022\026\035\034\027\024\005 \n\017\022\030\024\002\017\024\021\t )Tj 0.135 Tw T* ([15,27]. \211)Tj /Span<>> BDC ( )Tj EMC 4.45 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\024\f\035\024\032\027\036\027\027\t\n\017 )0.5(\235\024\030\n\026\n\017 )0.5(\007\017)]TJ 0 Tw (-)Tj 0.516 Tw -4.45 -1.218 Td [(\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.6(\002\024\035\036\027\017 )0.5(\024\021\n\036\004\026\036\021\f\016 )0.6(\027\026\004\017\021\036\035\034\027\024\036 )]TJ 0.2 Tw T* (\031\r\036\035\017\004\036\027\017\036 \002\026\022\021\036\030\017\005 \ \021\017\023\026 )Tj /T1_1 1 Tf 0 Tw [(Pro)13(teobacter)-36.9(ia)]TJ /T1_0 1 Tf 0.2 Tw ( \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.159 Tw T* (\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw [(Fir)-14(micutes)]TJ /T1_0 1 Tf 0.159 Tw ( \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\026\021\017\004\036\f\022\017 \027\036\024\f\035\024\ \032\027\036\027)Tj 0 Tw (-)Tj 0.27 Tw T* (\027\t\b \235\024\030\n\026\b, \004\021\024 \023\030\017\r\024\007\017\021\ \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\n\031 \007\017\f\002\026)Tj 0 Tw (-)Tj 0.455 Tw T* (\035\026\027\f\031 \n\036\032\007\031 \n\036\021\026\035\035\024\023\030\ \024\021\036\017\027\026\026\n\017, \r\t\007\036\035\016\036\n\t\n\017 \ )Tj /T1_1 1 Tf 0 Tw T* [(Bacteroid)26.1(ales)]TJ /T1_0 1 Tf 0.08 Tw (, \017)Tj /Span<>> BDC ( )Tj EMC [(\017\b \021\022\026\027\036\r\t\n\017 \017\027\020\017\002\017\021\024\030\ \026\n\017 $TIMP)35(s$, )]TJ 0.254 Tw T* (\031\f\017\035\017\r\026\016 \r\024\f\023\026\035\036\027\017\036 [28]. \ \225\031\013\036\f\021\r\031\036\021 \024\002\255\016\f\027\036\027\017\036\ )Tj -0.024 Tw T* (\021\024\020\024, \023\024\004\036\n\031 )Tj /T1_1 1 Tf 0 Tw [(Bacteroid)26.1(ales)]TJ /T1_0 1 Tf -0.024 Tw ( \f\023\024\f\024\002\027\t \r\t\032\017\r\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024)Tj 0 Tw (-)Tj 0.048 Tw T* [(\r\017\016\b )0.5(\007\017\r\036\030\021\017\022\031\035\017\021\026. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 9.687 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.6(Z)-16(i)-24(t)17(omer)-10(sk)-32(y)]TJ /Span<>> BDC ( )Tj EMC 10.798 0 Td (N.L. )Tj 0.15 Tw -20.485 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \002\t\035\024 )0.5(\023\024\022\026\026\027\024, \004\021\024 )]TJ /T1_1 1 Tf 0 Tw [(Bacteroid)26.1(ales)]TJ /T1_0 1 Tf 0.15 Tw ( \026\007\026\023\021\017\030\031)Tj 0 Tw (-)Tj 0.268 Tw T* (\033\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\024\005 \030\036\026\022\006\ \017\017 \023\031\021\036\n \220\022\f\023\030\036\f\f\017\017 )Tj 0.04 Tw T* (\020\036\027\024\r, \022\024\021\024\030\t\036 \n\036\021\026\002\024\035\ \017\017\030\031\033\021 \023\030\024\007\031\022\021\t \024\022\017\f\035\ \036\027\017\016 )Tj 0.115 Tw T* (\b\024\016\017\027\026, \004\021\024 \023\024\r\024\035\016\036\021 \023\ \030\036\007\023\024\035\024\032\017\021\034, \004\021\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005)Tj 0 Tw (-)Tj 0.295 Tw T* (\027\036\005 \n\036\030\036, \027\036\022\024\021\024\030\t\036 \r\017\007\ \t )Tj /T1_1 1 Tf 0 Tw (Bacteroides)Tj /T1_0 1 Tf 0.295 Tw ( \n\024\020\031\021 \002\t\021\034 )Tj 0.077 Tw T* (\035\031\004\001\036 \023\030\017\f\023\024\f\024\002\035\036\027\t \007\ \035\016 \r\t\032\017\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \r\024\f\023\026)Tj 0 Tw (-)Tj 0.092 Tw T* (\035\036\027\017\016, \004\021\024 \n\024\032\036\021 \002\t\021\034 \024\ \002\013\036\005 \024\f\024\002\036\027\027\024\f\021\034\033 \007\035\016\ \007\017)Tj 0 Tw (-)Tj 0.051 Tw T* (\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \026\002\024\035\036\r\ \026)Tj 0 Tw (-)Tj T* (\027\017\005 \022\017\001\036\004\027\017\022\026 [29,30].)Tj 0.205 Tw T* [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 S)15(tum)10(pf)]TJ /Span<>> BDC ( )Tj EMC (M. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\024\035\031\004\036\027\t \007\026\027)Tj 0 Tw (-)Tj 0.19 Tw T* (\027\t\036, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\034\033 )Tj 0.641 Tw T* (\027\026\002\035\033\007\026\035\026\f\034 \f\027\017\032\036\027\027\026\ \016 \220\022\f\023\030\036\f\f\017\016 \n\026\021\030\017\022\f\027\024\ \005 )Tj 0.155 Tw T* [(\n\036\021\026\035\035\024\023\030\024\021\036\017\027\026\t )0.6(\204\204\217-1, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.734 0 Td [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 )0.6(\027\036 )0.5(\002\t\035\024 )]TJ 0.11 Tw -12.734 -1.218 Td [(\f\031\013\036\f\021\r\036\027\027\024\005 )0.6(\030\026\027\017\006\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.87 0 Td [(\220\022\f\023\030\036\f\f\017\017 )0.6(\204\204\217-13 )0.5(\n\036\032\007\031 )]TJ 0.215 Tw -10.87 -1.218 Td (\023\026\006\017\036\027\021\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\034\033 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\030\024)Tj 0 Tw (-)Tj 0.191 Tw T* [(\r\t\n\017 )0.5(\031\004\026\f\021\027\017\022\026\n\017 )0.6([31]. )0.5(\210\007\027\026\022\024 )0.5(\031\f\017\035\036\027\027\026\016 )0.6(\023\030\024\007\031\022)]TJ 0 Tw (-)Tj 0.102 Tw T* (\006\017\016 \204\204\217-13 \r)Tj /Span<>> BDC ( )Tj EMC (\024\004\026\020\026\b \b\030\024\027\017\004\036\f\022\024\020\024 \r\024\ \f\023\026\035\036\027\017\016 \031\022\026)Tj 0 Tw (-)Tj 0.175 Tw T* (\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \220\021\024 \n\024\032\036\021 \017\020\030\026\021\ \034 \022\035\033\004\036\r\031\033 \030\024\035\034 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (126)Tj ET endstream endobj 60 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 61 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 62 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 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[(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036 \022\024\027\ \021\030\024\035\017\030\031\036\n\t\036 \017\f\023\t\021\026\027\017\016\ ,)5( )]TJ -0.022 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\006\036\027\017\r\026\035\017\f\034 \022\035\ \017\027\017\004\036\f\022\017\036 \017\f\b\024\007\t \023\026\006\017\036\ \027)Tj 0 Tc 0 Tw (-)Tj 0.005 Tc -0.051 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ \027\034\033, \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n \f\024\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.005 Tc 0.129 Tw T* [(\r\024\n \n\017\022\030\024\002\017\024\021\t, \220\022\f\023\036\030\017\ \n\036\027\021\026\035\034\027\t\036 \017\f\f\035\036\007\024\r\026\027\017\ \016)5( )]TJ 0.164 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\027\t\b \n\024\007\036\035\016\b \f)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\027\026\004\027\024 \024\023\030\036\007\036\035\036\027\ \027\t\n)5( )]TJ 0.25 Tw T* [(\007\017\026\005\027\024\n )0.5(\220\022\f\023\036\030\017\n\036\027\021\026, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 11.945 0 Td [(\021\026\022\032\036 )0.6(\n\036\021\026\026\027\026\035\017\t )0.5(\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc 0.407 Tw -11.945 -1.218 Td [(\002\024\021. \215\030\024\r\036\007\036\027 \026\027\026\035\017 \f\024\ \r\030\036\n\036\027\027\t\b \022\035\017\027\017\004\036\f\022\017\b)5.1( )]TJ 0.326 Tw T* (\030\036\022\024\n\036\027\007\026\006\017\005, \023\030\017\027\016\021\ \t\b \r)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\t\b \f\021\030\026\027\026\b \n\017\030\026.)5( )]TJ 0.385 Tw T* (\025\035\033\004\036\r\t\036 \f\035\024\r\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\026\023\030\024\f\t: di)-16(ver)-21.9(t)-32(icul)-15.9(ar disease;)5( )]TJ 0.199 Tw T* [(SUDD; intest)-32(inal micr)-32(obio)17(t)15.1(a; ENS, di)-16(ver)-22(t)-32(icul)30(osis and)5( )]TJ 0.243 Tw T* [(micr)-32(obio)17(t)15(a, A)17(UD, \007\017\r\036\030\021\017\022\031\035\016\030\027\026\016 \002\024\035\ \036\027\034, \n\017\022\030\024)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc 0.504 Tw T* (\002\017\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\017\r\036\030\021\017\022\031\035\017\021, \n\036\021\026\002\024\035\ \017\021\t \n\017\022\030\024\002\017\024\021\t.)5.1( )]TJ -0.018 Tw 0 -1.218 TD [(\215\036\030\r\017\004\027\024 \002\t\035\024 )0.5(\027\026\005\007\036\027\024: 14 \n\036\021\026\026\027\026\035\017\024\ \r, 342 \024\002\024)]TJ 0 Tc 0 Tw (-)Tj 0.005 Tc 0.11 Tw 0 -1.218 TD (\030\026, 116 \022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\ \024\r\026\027\017\005, 27 \220\022\f\023\036\030\017\n\036\027)Tj 0 Tc 0 Tw (-)Tj 0.005 Tc 0.215 Tw 0 -1.218 TD (\021\026\035\034\027\t\b \017\f\f\035\036\007\024\r\026\027\017\016. \215\ \024\f\035\036 \f\022\030\017\027\017\027\020\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\017)5( )]TJ 0.176 Tw T* (\030\036\033\n\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\031\033\013\017\n \017\031\004\036\027\017\036\n\ \023\024\035\027\t\b \021\036\022\f\021\024\r)5.1( )]TJ 0.149 Tw T* [(\f\021\026\021\036\005 \002\t\035\024 \024\021\024\002\030\026\027\024 1\ 2 \n\036\021\026\026\027\026\035\017\024\r, 24 \024\002\024\030\026,)5( )]TJ 0.001 Tw T* [(22 \022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\ \027\017\016, 5 \220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\ \t\b)5( )]TJ -0.005 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005.)Tj 0 Tc 0.078 Tw T* (\212\026\027\027\026\016 \f\021\026\021\034\016 \023\024\007\020\024\021\ \024\r\035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f\024 \f\021\026\027)Tj 0 Tw (-)Tj 0.077 Tw T* (\007\026\030\021\026\n\017 PRISMA \007\035\016 \031\035\031\004\001\036\027\ \017\016 \022\026\004\036\f\021\r\026 \024\021\004\036\021\027\024\f\021\ \017 )Tj 0.292 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \f\017\f\021\036\n\026\021\017\004\036\f\022\024\020\ \024 \024\002\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\036\027\017\016 )Tj -0.008 Tw T* (\023\030\024\030\026\004\027\024\f\021\017 \023\030\024\006\036\f\f\026\ \024\021\002\024\030\026 \f\021\026\021\036\005 \007\035\016 \f\017\f\021\ \036\n\026\021\017)Tj 0 Tw (-)Tj T* (\004\036\f\022\024\020\024 \024\002\024\030\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 408.2018 Tm [(\033\034\020)21(\223)50(\r\236)46(\024)52(\026)45(\024\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.149 Tw 10 0 0 10 42.5197 383.8458 Tm (\025 \027\026\f\021\024\016\013\036\n\031 \r\030\036\n\036\027\017 \027\026\ \022\024\023\035\036\027\024 \027\036 \021\026\022 \n\027\024\020\024 \030\ \036)Tj 0 Tw (-)Tj 0.158 Tw T* (\031\035\034\021\026\021\024\r \030\026\002\024\021, \027\026\023\030\026\ \r\035\036\027\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\017\030\024\r\026\027\017\036 )Tj 0.029 Tw T* (\022\017\001\036\004\027\024\020\024 \n\017\022\030\024\002\017\024\n\026\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ )Tj 0 Tw (-)Tj 0.019 Tw T* [(\027\017, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\r \036\013\036 \n\036\027\034\001\036\n )0.5(\004\017\f\035\036 \017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\026\r\021\024\030\t \023\t)]TJ 0 Tw (-)Tj 0.169 Tw T* (\021\026\035\017\f\034 \024\006\036\027\017\021\034 \017\n\036\027\036\027\ \017\016 \022\024\027\006\036\027\021\030\026\006\017\017 \022\017\001\036\ \004\027\t\b )Tj 0.078 Tw T* [(\n\036\021\026\002\024\035\017\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\030\024\r\017 )0.5(\023\026\006\017\036\027\021\024\r \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.559 0 Td [(\007\026\027\027\024\n )0.5(\026\002\024\035\036)]TJ 0 Tw (-)Tj -0.028 Tw -15.559 -1.218 Td [(\r\026\027\017\017. \212\026\027\027\t\036 \017\f\f\035\036\007\024\r\026\ \027\017\005 )0.5(\027\036\026\r\017\f\017\n\t\b \022\024\035\035\036\022\021\017)]TJ 0 Tw (-)Tj 0.112 Tw T* (\r\024\r \026\r\021\024\030\024\r \031\022\026\t\r\026\033\021 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\036 \235\036)Tj 0 Tw (-)Tj 0.185 Tw T* (\022\026\035\034\027\024\005 \n\017\022\030\024\002\017\024\021\t \023\026\ \006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )Tj 0.131 Tw T* (\002\024\035\036\027\034\033, \024\f\024\002\036\027\027\024 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \f\017\n\023\021\024\n\024\r, \f)Tj /Span<>> BDC ( )Tj EMC (\031\r\036)Tj 0 Tw (-)Tj 0.019 Tw T* (\035\017\004\036\027\017\036\n \022\024\035\017\004\036\f\021\r\026 \023\ \030\024\r\024\f\023\026\035\017\021\036\035\034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\027\006\017)Tj 0 Tw (-)Tj T* (\026\035\034\027\024 \023\026\021\024\020\036\027\027\t\b \002\026\022\021\ \036\030\017\005 [10,11,12].)Tj 0.311 Tw T* [(Bar)-24(bar)-32.9(a G. \f)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5(\r\t\016\r\017\035\017 \023\024\035\024\032\017\021\036\035\034\027\031\033\ )0.6(\022\024\030)]TJ 0 Tw (-)Tj 0.499 Tw T* (\030\036\035\016\006\017\033 \n\036\032\007\031 \017\027\021\036\027\f\017\ \r\027\024\f\021\034\033 \n\026\022\030\024\235\026\020\026\035\034\027\024\ \005 )Tj 0.153 Tw T* [(\017\027\235\017\035\034\021\030\026\006\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.262 0 Td [(\024\002\035\026\f\021\017 )0.5(\007\017\r\036\030\021\017\022\031\035\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.151 0 Td (\031\r\036\035\017\004\036\027\017)Tj 0 Tw (-)Tj 0.125 Tw -17.413 -1.218 Td (\036\n \002\026\022\021\036\030\017\005 \030\024\007\026 )Tj /T1_3 1 Tf [(Bacteroides, Prev)13(o)13(tella)]TJ /T1_1 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\027\031\033 )Tj 0.426 Tw T* (\022\024\030\030\036\035\016\006\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\024\n \023\030\036\007\f\021\026\r\017\021\036\035\036\005\ )Tj /T1_3 1 Tf 0 Tw [(Clostr)-36.9(idium )]TJ 0.146 Tw T* (\021\027\037\024\035\016\033\037 IV)Tj /Span<>> BDC ( )Tj EMC [(\227 F)15(aecalibacter)-36.8(ium p)46(rausnitzii,)]TJ /T1_1 1 Tf ( \022\024\021\024\030\t\036 )Tj 0.012 Tw T* (\024\002\035\026\007\026\033\021 \023\030\024\021\017\r\024\r\024\f\023\026\ \035\017\021\036\035\034\027\t\n \007\036\005\f\021\r\017\036\n \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0.063 Tw T* (\023\030\024\007\031\022\006\017\017 \002\031\021\017\030\026\021\026, \004\ \021\024 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC [(\030\036\020\031\035\016\006\017\017 T)50(r)-23.9(eg-)]TJ 0 Tw T* (\022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\024\022 T)47.1(h17 [13,14].)]TJ 0.226 Tw T* (\200 \023\030\024\r\024\007\017\n\t\b \017\f\f\035\036\007\024\r\026\027\ \017\016\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\033 \n\017\022\030\024)Tj 0 Tw (-)Tj 0.362 Tw T* [(\002\017\024\021\t )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 4.154 0 Td [(\002\024\035\034\027\t\b )0.6(\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )0.5(\002\024\035\036\027\034\033 )0.6(\007\035\016 )]TJ 0.47 Tw -4.154 -1.218 Td [(\024\006\036\027\022\017 )0.5(\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 )0.6(\027\026\004\017\n\024\f\021\017 )0.6(\007\017\026\020\027\024\f\021\017\022\017 )]TJ 0.259 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \022\024\n\023\035\036\022\f\026 \n\017\022\030\024\ \002\017\024\021\t Daniels L. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.064 Tw T* (\026\r\021. \002\t\035\017 \017\031\004\036\027\t \030\036\031\035\034\ \021\026\021\t \n\017\022\030\024\002\017\024\035\024\020\017\004\036\f\022\ \024\020\024 )Tj -0.027 Tw 23.244 64.543 Td (\026\027\026\035\017\026 \022\026\035\024\r\t\b \n\026\f\f \031)Tj /Span<>> BDC ( )Tj EMC (31 \004\036\035\024\r\036\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\r\024\f\021\024\030\024\027\027\017\n )Tj 0.053 Tw 0 -1.218 TD (\r\026\030\017\026\027\021\024\n \007\017\r\036\030\021\017\022\031\035\016\ \030\027\024\005 \002\024\035\036\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\025\224 \023\030\017\027\026\022\026)Tj 0 Tw (-)Tj 0.178 Tw 0 -1.218 TD (\n\017 \027\036\024\f\035\024\032\027\036\027\027\024\020\024 \007\017\r\ \036\030\021\017\022\031\035\017\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\031 25 \031\004\026\f\021\027\017)Tj 0 Tw (-)Tj 0.04 Tw 0 -1.218 TD (\022\024\r \022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\ \023\t. \212\035\016 \026\027\026\035\017\026 \002\t\035 \023\030\017\n\ \036\027\036\027 )Tj 0.142 Tw 0 -1.218 TD (\n\036\021\024\007 \023\024\035\017\n\036\030\026\027\024\005 \006\036\023\ \027\024\005 \030\036\026\022\006\017\017 $\215\037\217$ \r)Tj /Span<>> BDC ( )Tj EMC (\212\203\025-)Tj 0.027 Tw 0 -1.218 TD [(\017\024\035\016\021\026\b )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.143 0 Td [(\022\026\035\024\r\t\b )0.5(\024\002\030\026\006\024\r. )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 8.881 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC (\007\017\r\036\030)Tj 0 Tw (-)Tj 0.05 Tw -14.024 -1.218 Td [(\021\017\022\031\035\017\021\024\n )0.6(\002\t\035\024 )0.5(\024\002\027\026\030\031\032\036\027\024 )0.6(\002\024\035\036\036 )0.5(\001\017\030\024\022\024\036 )0.6(\030\026\f\023\030\024)]TJ 0 Tw (-)Tj 0.066 Tw 0 -1.218 TD [(\f\021\030\026\027\036\027\017\036 )0.5(\001\021\026\n\n\024\r )0.6(P)34.9(r)-31.9(o)17(teoba)-17(c)-16(ter)-37(ia. )0.5(\212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 )]TJ 0.267 Tw T* (\021\024\004\027\024\f\021\034 \030\036\020\030\036\f\f\017\024\027\027\024\ \005 \n\024\007\036\035\017, \023\030\017\n\036\027\016\036\n\024\005 \007\ \035\016 )Tj 0.209 Tw T* [(\023\030\036\007\f\022\026\026\027\017\016 \021\016\032\036\f\021\017 )0.5(\021\036\004\036\027\017\016 \026\002\024\035\036\r\026\027\017\016, \f\ \024\f\021\026)]TJ 0 Tw (-)Tj 0.214 Tw T* (\r\017\035\026 84%. \221\021\026\n\n\t, \024\002\035\026\007\026\033\013\ \017\036 \r\t\f\024\022\024\005 \023\026\021\024\020\036\027)Tj 0 Tw (-)Tj 0.285 Tw T* (\027\024\f\021\034\033, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n \002\t\035\017 \r\t\007\036\035\036\027\t \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\f\021\r\026 )Tj /T1_3 1 Tf 0 Tw T* [(Enterobacter)-36.9(iaceae)]TJ /T1_1 1 Tf 0.269 Tw (. \230\f\f\035\036\007\024\r\026\021\036\035\017 \023\030\017\001\035\017\ \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\024)Tj 0 Tw (-)Tj 0.372 Tw T* (\007\031 \024)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\024\005 \r\026\030\017\026\002\036\035\ \034\027\024\f\021\017 \n\017\022\030\024\002\017\024\021\t )Tj 0.178 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\t\n \007\017\r\036\030\021\017\022\031\035\017\021\024\n \ \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.175 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\035\024\032\017\035\017 \024\023\030\036\007\036\035\036\ \027\017\036 )Tj 0.211 Tw T* [(\022\035\026\f\021\036\030\024\r P)35(r)-32(o)17(teoba)-17(c)-16(ter)-36.9(ia \022\026\022 \023\024\021\036\027\006\017\026\035\034\027\t\005 \n\036\ \021\024\007 )]TJ 0 Tw T* (\007\017\026\020\027\024\f\021\017\022\017 \007\017\r\036\030\021\017\022\ \031\035\017\021\026 [15,16].)Tj -0.007 Tw T* [(K)20(v)-15(asnovsk)-31.9(y C.L. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \021\026\022\032\036 \023\030\024\026\027\026\035\017\ \017\030\024\r\026\035\017 \024\002)Tj 0 Tw (-)Tj -0.01 Tw T* (\030\026\006\t \022\026\035\026 \031)Tj /Span<>> BDC ( )Tj EMC (28 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ )Tj 0 Tw (-)Tj 0.034 Tw T* (\027\034\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \n\017\022\030\024\002\017\024\035\024\020\017\ \004\036\f\022\024\020\024 \023\030\024\235\017\035\017\030\024\r\026)Tj 0 Tw (-)Tj 0.126 Tw T* (\027\017\016 16S \030\217\203\025. \210\027\017 \024\002\027\026\030\031\ \032\017\035\017, \004\021\024 \002\024\035\036\036 \r\t\f\024\022\017\005\ )Tj 0.128 Tw T* (\023\024\022\026\026\021\036\035\034 \021\016\032\036\f\021\017 \f\017\n\ \023\021\024\n\024\r \002\t\035 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034)Tj 0 Tw (-)Tj T* (\001\036\027\017\036\n )Tj /T1_3 1 Tf 3.526 0 Td [(R)22(uminococcaceae)]TJ /T1_1 1 Tf 0.09 Tw [( )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC /T1_3 1 Tf 0 Tw 8.023 0 Td [(R)19(osebur)-36.9(ia)]TJ /T1_1 1 Tf 0.09 Tw [(, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.165 0 Td [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 )]TJ 0.622 Tw -16.714 -1.218 Td [(\017\027\021\036\027\f\017\r\027\024\f\021\034 )0.6(\002\024\035\017 )0.5(\027\026\004\017\021\036\035\034\027\024 )0.5(\022\024\030\030\036\035\017\030\024\r\026\035\026 )]TJ 0.54 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 1.209 0 Td [(\024\021\027\024\f\017\021\036\035\034\027\t\n )0.6(\023\030\036\024\002\035\026\007\026\027\017\036\n )0.6(\006\017\026\027\024\002\026\022\021\036\030\017\005. )]TJ 0.332 Tw -1.209 -1.218 Td (\237\023\017\024\007\t \024\f\021\030\024\020\024 \007\017\r\036\030\021\ \017\022\031\035\017\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n\027\036\036 \002\t\035\017 )Tj 0.446 Tw T* (\f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\004\030\036\n\036\030\027\t\n \030\024\f\021\024\n )Tj /T1_3 1 Tf 0 Tw [(Pseudobutyr)-36.9(ivibr)-37(io)]TJ /T1_1 1 Tf (, )Tj /T1_3 1 Tf T* [(Bi\241dobacter)-36.9(ium)]TJ /T1_1 1 Tf -0.014 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf 0 Tw [(Chr)-37(istensenellaceae)]TJ /T1_1 1 Tf -0.014 Tw (, \026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\036 \002\017\024\030\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\024\024\002\030\026\017\036 \n\017\022\030\024\002\017\024\n\026 \023\ \024\035\024\032\017\021\036\035\034\027\024 \022\024\030\030\036\035\017\ \030\024\r\026)Tj 0 Tw (-)Tj T* (\035\024 \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\035\034\023\030\024\021\036\022\021\017\027\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\235\036\022\026\035\017\016\b [17].)Tj 0.226 Tw T* [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 T)60(ur)-10(si A. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\026\027\026\035\017\017\030\024\r\026)Tj 0 Tw (-)Tj 0.201 Tw T* (\027\t \024\002\030\026\006\t \022\026\035\026 15 \023\026\006\017\036\027\ \021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 )Tj 0.343 Tw T* (\002\024\035\036\027\034\033, 13 \004\036\035\024\r\036\022 \f)Tj /Span<>> BDC ( )Tj EMC (\002\036\f\f\017\n\023\021\024\n\027\t\n \007\017\r\036\030\021\017)Tj 0 Tw (-)Tj 0.224 Tw T* (\022\031\035\036\024\n \017)Tj /Span<>> BDC ( )Tj EMC (16 \023\030\036\007\f\021\026\r\017\021\036\035\036\005 \022\024\027\021\ \030\024\035\034\027\024\005 \020\030\031\023\023\t, )Tj 0.305 Tw T* (\017\f\023\024\035\034\031\016 \023\024\007\b\024\007, \024\f\027\024\r\ \026\027\027\t\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\215\037\217. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n )Tj 0.083 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 \027\036 \r\t\016\r\035\036\027\ \024 )0.5(\030\026\035\017\004\017\005 )0.5(\n\036\032\007\031 \001\021\026\n)]TJ 0 Tw (-)Tj T* (\n\026\n\017 )Tj /T1_3 1 Tf 0.616 Tw 2.972 0 Td [(Bacteroides/Prev)13.1(o)13(tella, Clostr)-37(idium coccoides, )]TJ 0.038 Tw -2.972 -1.218 Td [(Bi\241dobacter)-36.9(ium, )0.6(Lactobacillus)]TJ /T1_1 1 Tf [( )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 12.902 0 Td [(Escher)-36.9(ichia )0.5(col)-30.9(i )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.415 0 Td (\021\030\036\b )Tj -0.032 Tw -20.317 -1.218 Td [(\020\030\031\023\023\026\b. \025\024\035\017\004\036\f\021\r\024 \001\021\ \026\n\n\026 Akk)10(er)-16(mansia muc)-24(iniphil)-15.9(a )]TJ 0.044 Tw T* (\027\026\004\017\021\036\035\034\027\024 \030\026\035\017\004\026\035\024\ \f\034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\026\021\017)Tj 0 Tw (-)Tj 0.004 Tw T* (\004\036\f\022\017 \024\f\035\024\032\027\036\027\027\024\005 \235\024\030\ \n\024\005 \007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\ \024\035\036)Tj 0 Tw (-)Tj -0.042 Tw T* (\027\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\n\017 \020\030\031\023\023\026\n\017. \202\027\ \026\035\017 \215\037\217 )Tj 0.105 Tw T* (\023\024\022\026\026\035 \002\024\035\036\036 \027\017\022\017\036 \031\ \030\024\r\027\017 N-\026\006\036\021\017\035\024\r\024\020\024 \f\024\036\ \007\017)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\017\024\r\026\035\036\030\026\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017)Tj 0 Tw (-)Tj 0.115 Tw T* (\022\031\035\016\030\027\024\005 \002\024\035\036\027\034\033, \004\021\ \024 \b\026\030\026\022\021\036\030\027\024 \007\035\016 \031\r\036\035\017\ \004\036\027\017\016 )Tj 0 Tw T* [(\004\017\f\035\036\027\027\024\f\021\017 Akk)10.1(er)-15.9(mansia munic)-23.9(iphil)-16(a [4,18].)]TJ 0.185 Tw T* [(\200 \017\f\f\035\036\007\024\r\026\027\017\017 Bar)-24(bar)-32(o M.R. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\024\026\027\026\035\017\017)Tj 0 Tw (-)Tj 0.211 Tw T* [(\030\024\r\026\027\t \024\002\030\026\006\t )0.5(\022\026\035\026 )0.5(16 \023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\002\036\f\f\017\n\023\021\024\n)Tj 0 Tw (-)Tj 0.383 Tw T* [(\027\t\n )0.5(\007\017\r\036\030\021\017\022\031\035\036\024\n, )0.6(8 )0.5(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 16.919 0 Td (\f\017\n\023\021\024\n\026\021\017)Tj 0 Tw (-)Tj 0.588 Tw -16.919 -1.218 Td (\004\036\f\022\017 \027\036\024\f\035\024\032\036\027\027\024\005 \007\017\ \r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \034\033 )Tj 0.105 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (14)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r \022\024\027\021\030\024\035\034\027\024\ \005 )0.5(\020\030\031\023\023\t \002\036 )0.5(\007\017\r\036\030\021\017\022\031)]TJ 0 Tw (-)Tj 0.064 Tw T* (\035\036\026. \210\002\013\017\005 \f\024\f\021\026\r \235\036\022\026\035\ \034\027\024\005 \n\017\022\030\024\002\017\024\021\t \027\026\004\017\n\ \024 )Tj -0.009 Tw T* (\027\036)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\026\035\f\016 \n\036\032\007\031 \021\030\036\n\016\ \020\030\031\023\023\026\n\017, \027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4397 56.0378 Tm (125)Tj ET endstream endobj 469 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 545.9841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 545.9841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 518.3763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 518.3763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 464.3071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.023 Tw 9 0 0 9 119.0551 730.4919 Tm [(with P)66(RISMA stand)26(ards.)]TJ 0.048 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: there is a decrease in the rep)46(resentation of Bacteroidetes, F)23.9(usobacter)-37(ium, Clostr)-37(idium clusters IV and IX, )]TJ 0.056 Tw T* [(Lactobacillaceae, and o)13(ther microorg)12.1(anis)33(ms with anti-inf)-21.9(lammator)-42.9(y p)46(roper)-40(ties and the ability to synthesize shor)-40(t-)]TJ 0.004 Tw T* [(chain fatty acids. In addition, in all types of div)13(er)-39.9(ticular disease, there is an increase in the population of R)19(osebur)-36.9(ia )]TJ 0.113 Tw T* [(hominis and Akk)17(er)-14(mansia muciniphila. With a com)16(plicated course of div)13(er)-40(ticular disease, there is an increase in )]TJ 0.095 Tw 0 -1.111 TD [(the number of rep)46.1(resentativ)13(es of the Pro)13(teobacter)-36.9(ia family)42(, and with sym)16(p)13(tomatically uncom)16(plicated div)12.9(er)-40(ticular )]TJ 0.112 Tw 0 -1.111 TD (disease)Tj /Span<>> BDC ( )Tj EMC [(\227 Fir)-14(micutes. According to studies, there is a chang)12(e in the concentration of specif)-43(ic ur)-36.9(inar)-43(y and fecal )]TJ 0.106 Tw T* [(biomark)17.1(ers in the blood)]TJ /Span<>> BDC ( )Tj EMC [(\227 hippurate, kininurenine and shor)-40(t-chain fatty acids, therefore, the assess)33(ment of the )]TJ 0.053 Tw T* [(metabolome may be considered a justif)-43(ied goal in deter)-14(mining and p)46(redicting chang)12(es in the microbiome in these )]TJ 0.023 Tw T* [(patients with div)13(er)-40(ticular disease.)]TJ 0.154 Tw T* [(C)21(ON)22(CLUSION: )0.5(there )0.5(is evidence )0.5(that an increase )0.5(in )0.5(the sev)13(er)-36.9(ity of )0.5(inf)-22(lammation )0.5(in div)13(er)-39.9(ticular )0.5(disease )0.5(may be )]TJ 0.049 Tw T* [(associated with an increase in the g)12(ener)-37(ic div)13(ersity of the fecal microbio)13.1(ta. Other bacter)-37(ial metabolites can act as )]TJ 0.023 Tw T* [(diagnostic and p)46(rognostic mark)17.1(ers of the sev)13(er)-36.9(ity of the disease.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 595.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( Div)13(er)-40(ticular disease, intestinal microbio)13.1(ta, microbio)13.1(ta and div)13(er)-39.9(ticulitis, microbio)13.1(ta metabolites, SUDD, A)29(UD, ENS)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw -4.948 -1.909 Td (FUNDING:)Tj /T1_0 1 Tf 0 Tc 0.17 Tw 4.225 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC 2.083 0 Td [(research )0.5(was )0.5(carried )0.5(out at )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(expense )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC 18.796 0 Td [(grant )0.5(from the)]TJ /Span<>> BDC ( )Tj EMC 6.416 0 Td [(Russian )0.5(Science )0.5(Foundation )0.5(No. 24-25-00020, )0.5(https://rscf.ru/)]TJ 0 Tw -31.524 -1.2 Td (project/24-25-00020/)Tj /T1_1 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(RESTS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 5.111 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interests)Tj /T1_1 1 Tf 0.037 Tc 0.092 Tw -10.423 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.4(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.101 Tw 6.536 0 Td [( S)-12.1(u)-14.9(v)-15.4(o)-11.8(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-23(.)-23.5(, K)-30.4(a)-11.2(k)-3.7(o)-15.8(t)-28.4(k)-41.1(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)40.6(V)39.7(.)-23.5(, A)-8.4(g)-8.1(a)-8.8(p)-22.3(o)-10.4(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-23.9(A)-23(. F)-25.2(e)-13(a)-18.2(t)-22.3(u)-7.6(r)-19(e)-22.8(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e g)-9.5(u)-16.3(t m)-14.6(i)-4.9(c)-22.4(r)-15.7(o)-11.6(b)-19.5(i)-6.8(o)-15.8(t)-36.8(a i)-3.2(n t)-26.1(h)-15.1(e)]TJ /Span<>> BDC ( )Tj EMC [(p)-20(a)-18.2(t)-26.1(h)-10.9(o)-18.6(g)-14.4(e)-11.5(n)-16.1(e)-22.8(s)-26.1(i)-7.4(s a)-7.5(n)-14.6(d c)-14.4(l)-16.6(i)-3.2(n)-14(i)-5(c)-21.5(a)-11.4(l c)-6.5(o)-13.3(u)-7.6(r)-30.3(s)-22.9(e)23( )]TJ 0.001 Tc -0.035 Tw -6.541 -1.2 Td [(o)-11.6(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-15.3(i)-14(v)-18.2(e)-11.5(r)-59.2(t)-45.6(i)-4.5(c)-11.6(u)-7.9(l)-37.2(a)-9.7(r d)-15.2(i)-6.9(s)-22.4(e)-12.5(a)-26(s)-22.4(e $)39.8(r)-18.6(e)-15.3(v)-51.2(i)-10.5(e)-12(w)20.2($)10.9(. )]TJ /T1_0 1 Tf 0.007 Tc -0.007 Tw [(K)10.4(o)-3.5(lo)-3.6(p)-1(rok)-22.6(t)-1.3(o)-3.6(lo)-6.8(g)-16.7(i)3.3(a)2.3(.)]TJ /T1_2 1 Tf 0.001 Tc -0.035 Tw 19.907 0 Td [( 2)-8.4(0)-3.3(2)-0.9(5)23.9(;)10.3(2)9.3(4)-12.9($)38.2(1)44.8($)15.1(:)21.4(1)0.5(2)-9.8(3)-11.5(\226)51.3(1)-7.4(3)-18.7(4. $i)-2.6(n R)-6(u)-21.4(s)-21.7(s)-15(.)43.7($)10.9(. h)-16.7(t)-48.9(t)-28.8(p)-18.2(s)-7.5(:)2.5(/)85.2(/)36.9(d)-10.5(o)-12(i.)3.2(o)-11.2(r)-16.2(g)-22.3(/)11.8(1)14.5(0)7(.)-5(3)8.4(3)-15.4(8)1.8(7)5.2(8)0.5(/)8.4(2)-8.4(0)9.9(7)-1.4(3)-12.8(-)41.8(7)11.2(5)0.9(5)-8.4(6)-26.2(-)10.3(2)-8.4(0)-3.3(2)-0.8(5)-23(-)10.2(2)9.4(4)-28(-)55.6(1)27.4(-)55.7(1)0.5(2)-9.8(3)-12.8(-)55.7(1)-7.4(3)-18.7(4)]TJ /T1_1 1 Tf 0.028 Tc 0.665 Tw -19.902 -2.617 Td [(\021\024\027\030\026)4.6( \024\033\023)4.6( \215\030\027\030\215\032\026\037\032:)]TJ /T1_0 1 Tf 0.019 Tc 0.669 Tw 12.238 0 Td [( \002)0.6(\023)0.5(\036)0.6(\034)0.5(\033)0.6(\034)0.5(\036)0.6( \215)0.5(\030)0.6(\n)0.6(\016)0.5(\024)0.6(\027)0.5(\037)0.6(\036)0.5( \213)0.6(\027)0.5(\016)0.6(\021)0.6(\024)0.5(\037)0.6(\020)0.5(\005)0.6(\033)0.5(\034)0.6(\036)0.5(\022)0.6(\n)0.5(,)0.6( \023)0.6(\027)0.5(.)]TJ /Span<>> BDC 18.825 0 Td ( )Tj EMC [(\255)0.6(\037)0.5(\005)0.6(\022)0.5(\217)0.6(\016)0.5(\036)0.6(\037)0.5(,)0.6( \005)0.6(.)]TJ /Span<>> BDC 7.161 0 Td ( )Tj EMC [(8)0.6(0)0.5(\253)0.6(\213)0.5(\273)0.6(,)0.5( \021)0.6(\036)0.5(.)]TJ /Span<>> BDC 6.003 0 Td ( )Tj EMC [(3)0.6(,)0.5( \r)0.6(\037)0.5(\027)0.6(\022)0.5(\020)0.6(\022)0.5(\020)0.6(\013)0.5(\033)0.6(\037)0.5(\005)0.6(,)0.5( \255)0.6(\034)0.6(\024)0.5(\024)0.5(\022)0.6(\030)0.6(;)19( )]TJ 0 Tc 0 Tw 12.46 0 Td ( )Tj 0.023 Tw -56.693 -1.2 Td (\035\016\027.: +7 $906$ 906-216-96-23; \016-mail: Suvorovvv9cheslav@ma\ il.ru)Tj /T1_1 1 Tf 0.01 Tc 0.055 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.6(F)12.9(OR)4.9( )0.6(C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.06 Tw 14.124 0 Td [( )0.5(Viacheslav )0.6(A. )0.5(Suv)13(orov)63.1(, )0.5(R)20(adishev)16(a )0.6(st., )0.5(80-1-3, )0.5(K)17(alining)14.1(rad, )0.5(236010, )0.6(R)22(ussia; )0.5(tel: )0.6(+7 )0.5($906$ )0.5(216-96-23; )0.6(e-mail: )]TJ 0 Tw -14.129 -1.2 Td [(Suv)13(orovvv9cheslav@mail.ru)]TJ 0 -2.792 TD (\203\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\201\034\024\027\016 \005\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 13.01.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\201\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 02.09.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 13.01.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 408.2019 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.012 Tc 0.342 Tw 10 0 0 10 70.8661 383.8459 Tm [(\200 \023\024\f\035\036\007\027\017\036 \007\036\f\016\021\017\035\036\021\ \017\016 \024\021\n\036\004\026\036\021\f\016 \031\f\021\024\005\004\017\ \r\026\016)12( )]TJ 0.238 Tw 0 -1.218 TD (\021\036\027\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\033 \030\026\f\023\030\024\f\021\030\026\ \027\036\027\027\024\f\021\017 \007\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.38 Tw T* (\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017. \217\026\f\023\030\024\f\021\030\026\027\036\027\027\024\f\021\034\ \007\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc -0.03 Tw T* [(\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017 \022\024\035\036\002\035\036\021\f\016 \024\021 5% \f\030\036\007\017\ \035\017\006)11.9( )]TJ 0.046 Tw T* (\n\035\026\007\001\036 40 \035\036\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\r\t\001\026\036\021 50% \r)Tj /Span<>> BDC ( )Tj EMC [(\r\024\030\026\f\021\036 \f\021\026\030\001\036)12( )]TJ 0.09 Tw T* (60 \035\036\021 [1]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \024\021\007\036\035\034\027\t\b \220\023\017\007\036\ \n\017\024\035\024\020\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.004 Tw T* [(\f\022\017\b \027\026\002\035\033\007\036\027\017\005, \f\017\n\023\021\024\ \n\026\021\017\004\036\f\022\017 \027\036\024\f\035\024\032\027\036\027\027\ \026\016)11.9( )]TJ 0.422 Tw T* [(\007\017\r\036\030\021\017\022\031\035\016\030\027\026\016 \002\024\035\036\ \027\034 \030\026\r\017\r\026\036\021\f\016 \023\030\017\n\036\030\027\ \024)12( )]TJ 0.239 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (25% \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\002\036\f\f\017\n\023\021\024\n\027\t\n \021\036\004\036\027\017\036\n \ )0.5(\007\017)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.118 Tw T* (\r\036\030\021\017\022\031\035\036\026, \026)Tj /Span<>> BDC ( )Tj EMC (\031 12% \023\026\006\017\036\027\021\024\r \027\026\002\035\033\007\026\ \036\021\f\016 \023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc -0.006 Tw T* (\020\030\036\f\f\017\030\024\r\026\027\017\036 \026\002\024\035\036\r\026\ \027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\r\017\021\017\036\n \f\017\n\023\021\024\n\024\r)12( )]TJ 0.273 Tw T* (\026\002\024\035\036\r\026\027\017\016, \r\024\f\023\026\035\017\021\036\ \035\034\027\t\b \024\f\035\024\032\027\036\027\017\005 \007\017\r\036\030\ )Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.189 Tw T* (\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\017 [2,3]\ . \231\026\f\021\024\021\026 \r\t\016\r\035\036\027\017\016 \007\017)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.103 Tw T* (\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\027\ \017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\021\036\030\030\017\021\024\030\017\017 \217\024\f\f\017\005\f\022\024\005\ )12( )]TJ -0.021 Tw T* [(\205\036\007\036\030\026\006\017\017, \f\024\020\035\026\f\027\024 \007\026\ \027\027\t\n \217\024\f\f\017\005\f\022\024\020\024 \024\002\013\036\f\021\ \r\026)12( )]TJ 0.205 Tw T* (\022\024\035\024\030\036\022\021\026\035\034\027\t\b \b\017\030\031\030\020\ \024\r [4], \021\026\022\032\036 \031\r\036\035\017\004\017\r\026\036\021\ )Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.133 Tw T* [(\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.174 0 Td [(\023\024\f\035\036\007\027\017\036 )0.5(\007\036\f\016\021\017\035\036\021\017\016. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 11.69 0 Td [(\004\026\f\021\027\024\f\021\017, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.642 0 Td (2002\226)Tj 0.24 Tw -19.506 -1.218 Td (2004)Tj /Span<>> BDC ( )Tj EMC (\020\020. \004\026\f\021\024\021\026 \r\t\016\r\035\036\027\017\016 \007\ \017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.145 Tw T* [(\035\036\027\017 )0.5(\f\024\f\021\026\r\035\016\035\026 )0.5(15,7% )0.5($\023\024 )0.5(\007\026\027\027\t\n )0.5(\037\036\027\021\030\026\035\034\027\024\020\024)12( )]TJ 0.789 Tw T* (\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034\f\ \022\024\020\024 \017\027\f\021\017\021\031\021\026 \020\026\f\021\030\024\ \220\027)Tj 0 Tc 0 Tw (-)Tj 0.012 Tc 0.097 Tw T* (\021\036\030\024\035\024\020\017\017$, \026)Tj /Span<>> BDC ( )Tj EMC (\r 2008\2262013)Tj /Span<>> BDC ( )Tj EMC (\020\020. \031\032\036 \007\024\f\021\017\020\026\035\026 17,6\226)Tj 0 Tw T* (22,6% [2,5].)Tj 0 Tc -0.01 Tw T* (\215\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\r\036\007\036\027\017\033 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\n\017 \235\024\030)Tj 0 Tw (-)Tj 0.074 Tw T* (\n\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\t\n\017 \024\002\024\f\021\030\036\027\017\016\n\017 \007\ \017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024)Tj 0 Tw (-)Tj 0.236 Tw T* [(\035\036\027\017 \023\024\f\021\024\016\027\027\024 \n\036\027\016\033\021\ \f\016 )0.5([6,7,8,9]. \215\030\024\007\024\035\032\026\036\021\f\016 )]TJ 0.427 Tw T* (\023\024\017\f\022 \024\023\021\017\n\026\035\034\027\024\005 \f\021\030\ \026\021\036\020\017\017, \036\007\017\027\024\020\024 \f\021\026\027\007\ \026\030\021\026 )Tj 0.158 Tw 23.244 32.881 Td [(\r\036\007\036\027\017\016 )0.5(\023\026\006\017\036\027\021\024\r, )0.6(\027\026\023\030\026\r\035\036\027\027\024\005 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 16.343 0 Td [(\f\027\017\032\036\027\017\016 )0.6(\004\026)]TJ 0 Tw (-)Tj -16.343 -1.218 Td (\f\021\024\021\t \024\002\024\f\021\030\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\f\021\017 \024\f\035\024\032\027\036\027\017\005.)Tj -0.048 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\t\b \023\031\021\036\005 \023\024\017\f\022\026 \024\ \023\021\017\n\026\035\034\027\024\005 \f\021\030\026)Tj 0 Tw (-)Tj 0.113 Tw T* (\021\036\020\017\017 \r\036\007\036\027\017\016 \023\026\006\017\036\027\ \021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\017\r\036\030\021\017\022\031\035\016\030\027\024\005 \002\024\035\036\ )Tj 0 Tw (-)Tj 0.133 Tw T* (\027\034\033 \016\r\035\016\036\021\f\016 \017\031\004\036\027\017\036 \ \030\024\035\017 \022\017\001\036\004\027\024\005 \n\017\022\030\024\002\ \017\024\021\t )Tj 0.082 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \026\002\024\035\036\r\026\027\017\ \016, \004\021\024 \023\024\r\024\035\017\021 \024\002\027\026\030\031\032\ \017\021\034 )Tj 0.229 Tw T* (\023\031\021\017 \023\030\016\n\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\r\036\027\027\024\020\024 \r\024\007\036\005\f\021\r\017\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r )Tj 0.074 Tw T* (\n\017\022\030\024\002\017\024\n\026, \023\024\r\024\035\016\033\013\017\ \036 \f\027\017\032\026\021\034 \004\026\f\021\024\021\031, \021\016\032\ \036\f\021\034 )Tj 0.23 Tw T* (\024\002\024\f\021\030\036\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\023\024\f\024\002\f\021\r\024\r\026\021\034 \023\ \030\024\235\017\035\026\022\021\017\022\036 )Tj 0 Tw T* (\030\036\006\017\007\017\r\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\007\036\030\032\026\027\017\033 \f\021\024\005\022\024\005 \ \030\036\n\017\f\f\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 262.0659 Tm (\017\034\r\236)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.012 Tw 10 0 0 10 303.3071 237.7099 Tm (\215\030\024\r\036\f\021\017 \026\027\026\035\017 \027\026\017\002\024\035\ \036\036 \023\036\030\f\023\036\022\021\017\r\027\t\b \027\026\023\030\026\ \r\035\036)Tj 0 Tw (-)Tj 0.109 Tw T* (\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \017\031\004\036\027\017\016 \n\017\022\030\024\ \002\017\024\n\026 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.213 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\027\t\n\017 \235\024\030\n\026\n\017 \007\ \017\r\036\030\021\017\022\031)Tj 0 Tw (-)Tj 0.177 Tw T* [(\035\016\030\027\024\005 )0.6(\002\024\035\036\027\017, )0.5(\022\024\021\024\030\t\036 )0.5(\n\024\020\031\021 )0.5(\002\t\021\034 )0.5(\017\f\023\024\035\034\024\r\026\027\t )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 152.4639 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.005 Tc 0.608 Tw 10 0 0 10 303.3071 128.1078 Tm (\212\035\016 \023\024\017\f\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\026 \017\027\235\024\030\n\026\006\017\017 \002\t\035\ \024\f\031)Tj 0 Tc 0 Tw (-)Tj 0.005 Tc 1.039 Tw T* [(\013\036\f\021\r\035\036\027 \f\017\f\021\036\n\026\021\017\004\036\f\022\ \017\005 \023\024\017\f\022 \035\017\021\036\030\026\021\031\030\t)5( )]TJ 0.356 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC 1.604 0 Td [(\220\035\036\022\021\030\024\027\027\t\n )0.5(\002\026\026\n )0.5(\007\026\027\027\t\b )0.5($P)20(ubMed, )0.5(EMBA)35(SE,)5( )]TJ 0.756 Tw -1.604 -1.218 Td [(Co)-16(chr)-32.9(ane, R)13(esear)-32(chga)15(te, S)-24(copus$ \026)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\027\017\036)5( )]TJ 0.881 Tw T* [(20 \035\036\021. \215\030\017\036\n\035\036\n\t\n\017 \017\f\f\035\036\007\ \024\r\026\027\017\016\n\017 \002\t\035\017)5( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8528 56.0378 Tm (124)Tj ET endstream endobj 466 0 obj [471 0 R] endobj 467 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 335.9485 42.7216 Tm [(F)20(eatur)31(es of\022th)11(e gut micr)20(obiota in th)11(e\022path)11(ogenesis and )]TJ 3.366 -1 Td [(clinical cour)20(se of\022div)12(er)-20(ticular disease $r)31(e)11(vie)11(w$)]TJ -42.49 1 Td [(\033\025\013\n \024\b\007\017\025\210\b\025\026\240 \016\022\223\005\026\ )11(\025\020)10(\f\t\f\001\f \b\022\007)-10(\013\b\t\b\213\f\205\007)10(\025\024 \026)11(\f\213\f\t\b\b )]TJ 0 -1 TD [(\217\b\016\f\017\026\b\007\220\013\017\t\025\255 \210\025\013\f\001\t\b\ $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 267.141 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 267.141 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 239.5332 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 239.5332 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-1-123-134)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 53.8749 695.3259 Tm [(\033\025\013\n \024\b\007\017\025\210\b\025\026\240 \016\022)-23.3(\223\005\026)11(\025\020)10.1(\f\t\f\001\f \b\022)-23.3(\007)-10(\013\b\t\b\213\f\205\007)10(\025\024 \026)11(\f\213\f\t\b\b )]TJ 1.602 -1.105 Td [(\217\b\016\f\017\026\b\007\220\013\017\t\025\255 \210\025\013\f\001\t\b\ $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-19.9(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 649.822 Tm [(\207\220\016\025\017\025\016\022)-23.2(\r.\006)-31(., \037)41(\005\007)10(\025\026\007\b\t\022)-23.2(\r.\r., \006\020)10(\005\223\025\016\022)-23.2(\204.\006)-31(.)]TJ 10 0 0 10 42.5197 632.1527 Tm [(\201\031)83(\006\036)20(\230 \r\036 \253\214\005\013\026\b\255\205\007\b\255 \211\f\217\f\017\005\ \013\n\t\240\255 \220\t\b\016\f\017\205\b\026)11.1(\f\026 \b\024\f\t\b \030\024\024\005\t\220\b\013\005 \037)40.9(\005\t\026)11.1(\005\273 $\220\013.\022)-23.3(\006)-31(.\022)-23.2(\202\f\016\205\007)10(\025\020)10(\025, \217.\022)-23.3(1)150(4, )]TJ 0 -1.2 TD [(\020)62(.\022)-23.3(\037)41(\005\013\b\t\b\t\020\017\005\217, 2360)25(4)103(1)69(, \033\025\205\205\b$)]TJ /T1_1 1 Tf 0.133 Tw 9 0 0 9 90.7087 601.6488 Tm (\212\205\216\221: \f\033\034\036\016\024\035\022 \037\020\037\027\022\031\ \020\037\022\025\034\027\016\016 \f\016\033\024\f\016\021\035\022\036\020\ \032\001 \020\037\f\033\037\036\027\016\020\022\t \036)Tj /Span<>> BDC ( )Tj EMC (\034\025\027\037\024\035\022 \022\031\023\n\016\020\022\030 \b\022\021\033\ \034\025\022\034\b\037 \035\034\027\024\035\034\t )Tj 0.014 Tw 0 -1.111 TD (\021\022\004\021\022 \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\006\022\016\020\035\034\036 \024)Tj /Span<>> BDC ( )Tj EMC (\034\024\027\034\003\020\016\020\020\032\b\022 \017\034\033\b\037\b\022 \ \005\022\036\016\033\035\022\021\023\027\030\033\020\034\t \025\034\027\016\ \031\020\022, \021\034\035\034\033\032\016 \b\034\013\023\035 \025\032\035\ \007 \022\024\f\034\027\007\031\034\036\037)Tj 0 Tw (-)Tj 0.023 Tw T* (\020\032 \036)Tj /Span<>> BDC ( )Tj EMC (\021\027\022\020\022\n\016\024\021\034\t \f\033\037\021\035\022\021\016.\ )Tj 0.199 Tw T* (\240\213\200\205\255\235\213\216\223 \235)Tj /Span<>> BDC ( )Tj EMC (\240\205\200\211\203\223: \036\032\f\034\027\020\016\020 \024\022\024\035\ \016\b\037\035\022\n\016\024\021\022\t \f\034\022\024\021 \027\022\035\016\ \033\037\035\023\033\032 \f\034)Tj /Span<>> BDC ( )Tj EMC (\220\027\016\021\035\033\034\020\020\032\b \025\037\031\037\b \005\037\020\ \020\032\001 )Tj 0.073 Tw T* ($PubMed, EMBASE, Cochrane, Researchgate, Scopus$ \031\037)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\005\020\022\016 20 \027\016\035. \201\016\033\036\022\ \n\020\034 \025\032\027\034 \020\037\t\005\016\020\034: 14 \b\016\035\037\ \037)Tj 0 Tw (-)Tj 0.04 Tw 0 -1.111 TD [(\020\037\027\022\031\034\036, )0.5(342 \034\025\031\034\033\037, 116 \021\027\022\020\022\n\016\024\021\022\ \001 \022\024\024\027\016\005\034\036\037\020\022\t, )0.5(27 \220\021\024\f\016\033\022\b\016\020\035\037\027\007\020\032\001 \022\ \024\024\027\016\005\034\036\037\020\022\030. \201\034\024\027\016 \024\021\ \033\022\020\022\020\013\037 )]TJ 0.06 Tw 0 -1.111 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\034\006\016\020\021\022 \033\016\031\026\b\016 \025\032\027\034 \034\035\ \034\025\033\037\020\034 12 \b\016\035\037\037\020\037\027\022\031\034\036\ , 24 \034\025\031\034\033\037, 22 \021\027\022\020\022\n\016\024\021\022\ \001 \022\024\024\027\016\005\034\036\037\020\022\030, 5 \220\021\024\f\016\ \033\022\b\016\020)Tj 0 Tw (-)Tj 0.023 Tw T* (\035\037\027\007\020\032\001 \022\024\024\027\016\005\034\036\037\020\022\ \t. \203\037\020\020\037\030 \024\035\037\035\007\030 \f\034\005\013\034\ \035\034\036\027\016\020\037 \036)Tj /Span<>> BDC ( )Tj EMC (\024\034\034\035\036\016\035\024\035\036\022\022 \024\034 \024\035\037\020\ \005\037\033\035\037\b\022 PRISMA.)Tj 0.092 Tw T* [(\255\205\202\207\216\221\200\213\200\223: )0.6(\023)]TJ /Span<>> BDC ( )Tj EMC 6.523 0 Td [(\f\037\006\022\016\020\035\034\036 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 5.645 0 Td [(\005\022\036\016\033\035\022\021\023\027\030\033\020\034\t )0.7(\025\034\027\016\031\020\007\026 )0.6(\020\037\025\027\026\005\037\016\035\024\030 )0.5(\024\020\022\003\016\020\022\016 )0.5(\021\034\027\022\n\016\024\035\036\037 )0.6(Bacteroidetes, )]TJ 0.012 Tw -12.168 -1.111 Td [(Fusobacterium, )0.5(\021\027\037\024\035\016\033\034\036 )0.5(Clostridium IV )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 17.286 0 Td [(IX, Lactobacillaceae, )0.7(\037)]TJ /Span<>> BDC ( )Tj EMC [(\035\037\021\003\016 )0.5(\005\033\023\013\022\001 \b\022\021\033\034\034\033\013\037\020\022\031\b\ \034\036, \034\025\027\037\005\037\026\217\022\001 )]TJ 0.044 Tw -17.286 -1.111 Td [(\f\033\034\035\022\036\034\036\034\024\f\037\027\022\035\016\027\007\020\ \032\b\022 )0.8(\024\036\034\t\024\035\036\037\b\022 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 17.509 0 Td [(\024\f\034\024\034\025\020\032\001 )0.6(\024\022\020\035\016\031\022\033\034\036\037\035\007 )0.5(\021\034\033\034\035\021\034\006\016\f\034\n\016\n\020\032\016 )0.6(\003\022\033\020\032\016 )0.5(\021\022\024\027\034\035\032. )]TJ 0.022 Tw -17.509 -1.111 Td (\r\033\034\b\016 \035\034\013\034, \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\036\024\016\001 \035\022\f\037\001 \005\022\036\016\033\035\022\021\023\ \027\030\033\020\034\t \025\034\027\016\031\020\022 \f\033\034\022\024\001\ \034\005\022\035 \023\036\016\027\022\n\016\020\022\016 \f\034\f\023\027\ \030\006\022\022 Roseburia hominis )Tj 0.153 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (Akkermansia muciniphila. \201\033\022)Tj /Span<>> BDC ( )Tj EMC (\034\024\027\034\003\020\016\020\020\034\b \035\016\n\016\020\022\022 \005\ \022\036\016\033\035\022\021\023\027\030\033\020\034\t \025\034\027\016\031\ \020\022 \034\035\b\016\n\037\016\035\024\030 \023\036\016\027\022\n\016\ \020\022\016 )Tj 0.118 Tw T* (\021\034\027\022\n\016\024\035\036\037 \f\033\016\005\024\035\037\036\022\ \035\016\027\016\t \024\016\b\016\t\024\035\036\037 Proteobacteria, \037\ )Tj /Span<>> BDC ( )Tj EMC (\f\033\022 \024\022\b\f\035\034\b\037\035\022\n\016\024\021\022 \020\016\ \034\024\027\034\003\020\016\020\020\034\t \005\022\036\016\033\035\022)Tj 0 Tw (-)Tj 0.097 Tw T* (\021\023\027\030\033\020\034\t \025\034\027\016\031\020\022)Tj /Span<>> BDC ( )Tj EMC (\227 Firmicutes. \002\034\013\027\037\024\020\034 \022\024\024\027\016\005\ \034\036\037\020\022\030\b, \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\006\022\016\020\035\034\036 \024)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\027\022\n\020\032\b\022 \017\034\033\b\037\b\022 \005\022\036\ \016\033\035\022\021\023)Tj 0 Tw (-)Tj 0.134 Tw T* (\027\030\033\020\034\t \025\034\027\016\031\020\022 \036)Tj /Span<>> BDC ( )Tj EMC (\021\033\034\036\022 \034\035\b\016\n\037\016\035\024\030 \022\031\b\016\ \020\016\020\022\016 \021\034\020\006\016\020\035\033\037\006\022\022 \024\ \f\016\006\022\017\022\n\016\024\021\022\001 \b\034\n\016\036\032\001 \022\ )Tj /Span<>> BDC ( )Tj EMC (\017\016\021\037\027\007\020\032\001 \025\022\034)Tj 0 Tw (-)Tj 0.13 Tw T* (\b\037\033\021\016\033\034\036)Tj /Span<>> BDC ( )Tj EMC (\227 \013\022\f\f\023\033\037\035\037, \021\022\020\022\020\023\033\016\020\ \022\020\037 \022)Tj /Span<>> BDC ( )Tj EMC (\021\034\033\034\035\021\034\006\016\f\034\n\020\032\001 \003\022\033\020\ \032\001 \021\022\024\027\034\035, \f\034\220\035\034\b\023 \034\006\016\ \020\021\037 \b\016\035\037\025\034\027\034\b\037 )Tj -0.003 Tw T* [(\b\034\003\016\035 )0.5(\024\n\022\035\037\016\035\024\030 )0.5(\034\f\033\037\036\005\037\020\020\034\t )0.6(\006\016\027\007\026 \f\033\022)]TJ /Span<>> BDC ( )Tj EMC 17.966 0 Td [(\034\f\033\016\005\016\027\016\020\022\022 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 6.229 0 Td [(\f\033\034\013\020\034\031\022\033\034\036\037\020\022\022 \022\031\b\016\ \020\016\020\022\030 )0.5(\b\022\021\033\034\025\022\034\b\037 )0.5(\023)]TJ /Span<>> BDC ( )Tj EMC 17.819 0 Td (\005\037\020\020\032\001 )Tj 0 Tw -42.014 -1.111 Td (\f\037\006\022\016\020\035\034\036.)Tj 0.014 Tw T* (\202\213\r\216\225\210\205\222\235\205: \033\016\031\023\027\007\035\037\ \035\032 \022\024\024\027\016\005\034\036\037\020\022\t \023\021\037\031\ \032\036\037\026\035 \020\037)Tj /Span<>> BDC ( )Tj EMC (\035\034, \n\035\034 \025\037\027\037\020\024 \b\016\003\005\023 \024\022\ \b\025\022\034\035\037\b\022 \022)Tj /Span<>> BDC ( )Tj EMC (\f\037\035\034\025\022\034\020\035\037)Tj 0 Tw (-)Tj 0.122 Tw 0 -1.111 TD (\b\022 \022\013\033\037\016\035 \036\037\003\020\023\026 \033\034\027\007\ \036)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\017\022\027\037\021\035\022\021\016 \036\034\031\020\022\021\020\ \034\036\016\020\022\030 \005\022\024\025\022\034\031\037, \021\034\035\034\ \033\032\t \024\f\034\024\034\025\016\020 \023\024\023\013\023\025\022\035\ \007 \036\034\024\f\037\027\022)Tj 0 Tw (-)Tj 0.09 Tw 0 -1.111 TD [(\035\016\027\007\020\032\t )0.6(\f\033\034\006\016\024\024 )0.6(\036)]TJ /Span<>> BDC ( )Tj EMC 8.35 0 Td [(\034\025\027\037\024\035\022 )0.6(\005\022\036\016\033\035\022\021\023\027\034\036 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 10.931 0 Td [(\024\f\034\024\034\025\024\035\036\023\016\035 )0.7(\033\037\031\036\022\035\022\026 )0.5(\034\024\027\034\003\020\016\020\022\t. )0.6(\235\b\016\026\035\024\030 )0.6(\005\037\020\020\032\016, )0.6(\n\035\034 )]TJ 0.023 Tw -19.281 -1.111 Td [(\023\024\022\027\016\020\022\016 )0.5(\035\030\003\016\024\035\022 \036\034\024\f\037\027\016\020\022\030 )0.5(\f\033\022)]TJ /Span<>> BDC ( )Tj EMC 14.814 0 Td [(\005\022\036\016\033\035\022\021\023\027\030\033\020\034\t )0.6(\025\034\027\016\031\020\022 )0.5(\b\034\003\016\035 \025\032\035\007 \024\036\030\031\037\020\034 \024)]TJ /Span<>> BDC ( )Tj EMC 20.977 0 Td (\023\036\016\027\022\n\016\020\022\016\b \033\034\005\034\036\034\013\034\ )Tj 0.056 Tw -35.791 -1.111 Td (\033\037\031\020\034\034\025\033\037\031\022\030 \017\016\021\037\027\007\ \020\034\t \b\022\021\033\034\025\022\034\035\032. \211\035\005\016\027\007\ \020\032\016 \025\037\021\035\016\033\022\037\027\007\020\032\016 \b\016\ \035\037\025\034\027\022\035\032 \b\034\013\023\035 \036\032\024\035\023\ \f\037\035\007 \036)Tj /Span<>> BDC ( )Tj EMC (\021\037\n\016)Tj 0 Tw (-)Tj 0.074 Tw T* (\024\035\036\016 \005\022\037\013\020\034\024\035\022\n\016\024\021\022\001\ \022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\013\020\034\024\035\022\n\016\024\021\022\001 \b\037\033\021\016\ \033\034\036 \035\030\003\016\024\035\022 \035\016\n\016\020\022\030 \031\ \037\025\034\027\016\036\037\020\022\030. \203\037\027\007\020\016\t\004\ \016\016 \022\031\023\n\016\020\022\016 )Tj 0.117 Tw T* (\024\034\024\035\037\036\037 \021\022\004\016\n\020\034\t \b\022\021\033\ \034\025\022\034\035\032 \022)Tj /Span<>> BDC ( )Tj EMC (\036\027\022\030\020\022\030 \016\016 \b\016\035\037\025\034\027\022\035\ \034\036 \020\037)Tj /Span<>> BDC ( )Tj EMC (\035\016\n\016\020\022\016 \005\022\036\016\033\035\022\021\023\027\030\033\ \020\034\t \025\034\027\016\031\020\022 \b\034\013\023\035 )Tj 0.277 Tw T* (\024\f\034\024\034\025\024\035\036\034\036\037\035\007 \033\037\031\033\037\ \025\034\035\021\016 \034\f\035\022\b\037\027\007\020\034\t \024\035\033\ \037\035\016\013\022\022 \036\016\005\016\020\022\030 \f\037\006\022\016\ \020\035\034\036, \020\037\f\033\037\036\027\016\020\020\034\t \020\037)Tj /Span<>> BDC ( )Tj EMC (\024\020\022\003\016\020\022\016 )Tj 0.023 Tw T* (\n\037\024\035\034\035\032, \035\030\003\016\024\035\022 \034\025\034\024\ \035\033\016\020\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\017\022\027\037\021\035\022\021\023 \033\016\006\022\005\022\036\ \034\036.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 42.5596 316.3795 Tm [(\037\033\255\200\030\025\202\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \005\022\036\016\033\035\022\021\023\027\030\033\020\037\030 \025\034\027\ \016\031\020\007, \034\024\027\034\003\020\016\020\022\030, \021\022\004\ \016\n\020\037\030 \b\022\021\033\034\025\022\034\035\037, \b\022\021\033\ \034\025\022\034\035\037 \022)Tj /Span<>> BDC ( )Tj EMC (\005\022\036\016\033\035\022\021\023\027\022\035, \b\016\035\037\025\034\ \027\022\035\032)Tj /T1_2 1 Tf 0.023 Tc -0.023 Tw -8.493 -1.909 Td (\034\032\035\021\035\026\032\027\036\025\021\035\032\030:)Tj /T1_1 1 Tf 0.013 Tc 0.465 Tw 8.844 0 Td ( \022\024\024\027\016\005\034\036\037\020\022\016 \036\032\f\034\027\020\ \016\020\034 \031\037)Tj /Span<>> BDC ( )Tj EMC (\024\n\016\035 \013\033\037\020\035\037 \255\034\024\024\022\t\024\021\034\ \013\034 \020\037\023\n\020\034\013\034 \017\034\020\005\037 \24724-25-0\ 0020, https://rscf.ru/)Tj 0 Tc 0 Tw -8.849 -1.2 Td (project/24-25-00020/)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.018 Tc -0.04 Tw -10.401 -2.617 Td [(\024\033\023)4.7( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.008 Tc -0.035 Tw 8.892 0 Td ( \225\031\r\024\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \025\026\022\024\021\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \202\020\026\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202. \217\024\035\034 \n\017\022\030\024\002\017\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\024\n \021\036\004\036\027\017\017 \007\ \017\r\036\030\021\017\022\031\035\016\030\027\024\005)8( )]TJ 0.011 Tc -8.897 -1.2 Td (\002\024\035\036\027\017 $\024\002\024\030 \035\017\021\036\030\026\021\ \031\030\t$. )Tj /T1_1 1 Tf -0.011 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030.)Tj /T1_3 1 Tf -0.035 Tw ( 2025; \021.)Tj /Span<>> BDC ( )Tj EMC (24, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (123\226134. https://doi.org/10.33878/2073-7556-2025-24-1-123-134)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 75.4762 213.3639 Tm [(F)20(eatur)31(es of\022)-23.2(th)11(e gut micr)20(obiota in th)11(e\022)-23.3(path)11(ogenesis and )]TJ 1.718 -1.167 Td [(clinical cour)20(se of\022)-23.2(div)12(er)-20(ticular disease $r)31.1(e)10.9(vie)11.1(w$)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 167.8599 Tm [(Viach)11(eslav\022)-23.2(A)-31(.\022)-23.3(Su)10(v)10(or)20(ov)21(, Viktor\022)-23.2(V)62(.\022)-23.3(K)41(ak)11(otkin, Mikhail\022)-23.2(A)-31(.\022)-23.3(Agapov)]TJ 10 0 0 10 42.5197 150.1907 Tm [(Immanuel K)41(ant Baltic F)19.9(eder)21.1(al Univ)12(er)20(sit)-19.9(y $A)-31(. Ne)11(v)10(sky\022)-23.2(st., 1)150(4, K)40.9(aliningr)21(ad, 2360)25.1(4)103(1)69(, Russia$)]TJ /T1_1 1 Tf 0.036 Tw 9 0 0 9 90.7087 131.6868 Tm [(AIM: )0.6(to )0.5(assess )0.6(the )0.6(most )0.5(p)46(romising )0.6(areas )0.6(in )0.6(the )0.5(f)-43(ield )0.6(of )0.6(studying )0.6(the )0.5(microbiome )0.6(of )0.5(the )0.5(colon )0.6(in )0.5(patients )0.5(with )0.6(com)]TJ 0 Tw (-)Tj 0.023 Tw T* [(plicated for)-14(ms of div)13(er)-40(ticular disease, which can be used in clinical p)46(ractice.)]TJ 0.192 Tw T* [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: a systematic literature search of electronic )0.5(d)26(atabases $PubMed, EMB)20(A)49.9(SE, Cochrane, )]TJ 0.057 Tw T* [(R)21(esearch g)12(ate, Scopus$ for the past 20 years w)13(as done. Initially)42.1(, 14 meta-analyses, 342 revie)10(ws, 116 clinical stud)]TJ 0 Tw (-)Tj 0.096 Tw T* [(ies, and 27 e)-15(xper)-36.9(imental studies w)12(ere found. Af)-46(ter screening and ev)16(aluating the summar)-43(y)42(, 12 meta-analyses, 24 )]TJ 0.039 Tw 0 -1.111 TD [(revie)10(ws, 22 clinical studies, )0.5(and 5 e)-15(xper)-36.9(imental studies w)12(ere selected. )0.5(This ar)-40(ticle has been p)46(repared in accord)26(ance )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 610.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 601.226 Tm (\027\030\203\255\204\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 140.1909 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 131.2636 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 505.4771 56.0378 Tm (123)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c 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Diseases of)Tj /Span<>> BDC ( )Tj EMC [(the Colon & R)21.1(ectum)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj T* (2007;50:870\226877.)Tj 0.24 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(enne)-12(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(A. )0.6(K)25(udsk, )0.5(M. )0.5(K)25(ei)-24(t)-13(h )0.5(Hanna. )0.6(Mana)-17(gement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 22.474 0 Td [(Com)10(ple)-18(x )]TJ 0.023 Tw -24.27 -1.25 Td [(P)30(er)-37(ineal Injur)-37(ies. )]TJ /T1_1 1 Tf [(W)29(ord jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(surg)12(er)-42.9(y)]TJ /T1_0 1 Tf (. 2003;27$8$:895\226900.)Tj 0.007 Tc 0.349 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.822 0 Td [(Jegana)15.4(t)-12.6(han)]TJ /Span<>> BDC ( )Tj EMC [(A)51.4(N, Can)0.5(non)]TJ /Span<>> BDC ( )Tj EMC (JW, Bleier)Tj /Span<>> BDC ( )Tj EMC [(JIS. 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Ba)15(t)-30(tle Injur)-36.9(ies O)-32(f)]TJ /Span<>> BDC ( )Tj EMC [(T)47(he R)13(ec)-16(tum: )]TJ 0.201 Tw -1.796 -1.25 Td [(Opt)-32(ions F)10(or T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(F)-19(ield Sur)-32(geon. )]TJ /T1_1 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(the ro)12(yal ar)-14(m)11(y medical )]TJ 0 Tw T* [(cor)-18(ps. )]TJ /T1_0 1 Tf 2.603 0 Td (2002;148:27\22631.)Tj 0.153 Tw -2.603 -1.25 Td (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Must)15(af)16(a)]TJ /Span<>> BDC ( )Tj EMC [(T)20(O, Al)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(K)20(C, Is)26(mail)]TJ /Span<>> BDC ( )Tj EMC (HO. Use of)Tj /Span<>> BDC ( )Tj EMC [(v)-15(a)-17(cuum-assisted cl)30(osur)-23.9(e )]TJ -0.019 Tw -1.796 -1.25 Td [($V)37(A)16(C\264$ in high-ener)-32(g)16(y com)10(pl)-31(ica)15(ted per)-37(ineal injur)-37(ies: anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC (nine )Tj 0 Tw T* (cases. )Tj /T1_1 1 Tf 0.023 Tw 2.697 0 Td [(Inter)-14(national w)12(ound jour)-14(nal. )]TJ /T1_0 1 Tf 0 Tw (2011;8$6$:599\226607.)Tj 0.026 Tw -2.697 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gl)-16(asgo)-13.9(w)]TJ /Span<>> BDC ( )Tj EMC [(SC, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Epidemiol)30.1(o)-16(g)16(y of)]TJ /Span<>> BDC ( )Tj EMC [(moder)-15(n ba)15(t)-30(tlef)-28(ield col)30(or)-23.9(ec)-16(t)15(al )]TJ 0.158 Tw -1.796 -1.25 Td [(tr)-33(auma: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ev)-15.9(iew of)]TJ /Span<>> BDC ( )Tj EMC [(977 coal)-30.9(i)-24(t)-32(ion casual)56(t)-31.9(ies. )]TJ /T1_1 1 Tf [(J T)56(rauma Acute Care )]TJ 0 Tw T* (Surg)Tj /T1_0 1 Tf 0.023 Tw (. 2012; 73$6$, Suppl. 5: 503-S508.)Tj 0.157 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(und)17(y)]TJ /Span<>> BDC ( )Tj EMC [(JB, Dr)-37(iscol)]TJ /Span<>> BDC ( )Tj EMC [(IR. E)35(xper)-36.9(ience wi)-23.9(t)-13(h P)35(r)-32(o)-16(c)-16(tec)-15.9(t)17(omy t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Mana)-17(ge )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(Comba)15.3(t Casual)56.3(t)-31.6(ies Sust)15.3(aining Ca)15.4(t)15.3(astr)-31.7(ophic P)30.4(er)-36.6(ineal Bl)-15.6(ast Injur)-23.7(y)1( )]TJ 0.007 Tc T* [(Com)10.3(pl)-30.6(ica)15.3(ted b)12.3(y Inv)-14.6(asi)-15.6(ve Mucor S)-15.6(of)-27.6(t-T)35.3(issue Infec)-15.7(t)-31.6(ions. )]TJ /T1_1 1 Tf -0.007 Tw [(Militar)-42.6(y)7( )]TJ 0 Tc 0 Tw T* (Medicine.)Tj /T1_0 1 Tf 0.023 Tw ( 2014;179:347\226350.)Tj 0.138 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(abler)]TJ /Span<>> BDC ( )Tj EMC 2.85 0 Td [(L, )0.5(T)50(r)-24(entz)]TJ /Span<>> BDC ( )Tj EMC 3.877 0 Td (O.)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.138 Tw 1.223 0 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 1.771 0 Td [(use )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 2.93 0 Td [(v)-15(a)-17(cuum )0.5(assisted )0.6(cl)30(osur)-24(e )0.5($V)37(A)16(C\264$ )]TJ 0.072 Tw -14.446 -1.25 Td [(in sof)-28(t t)-32(issue injur)-36.9(ies af)-28(ter high ener)-32(g)16(y pel)30(v)-16(ic tr)-32.9(auma. )]TJ /T1_1 1 Tf 0 Tw [(Lang)12(enbeck)-22.9(s )]TJ 0.023 Tw T* [(archiv)13(es surg)12(er)-43(y.)]TJ /T1_0 1 Tf ( 2006;392:601\226609.)Tj 0.289 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mil)16(chesk)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC 4.264 0 Td [(D)20(A, )0.6(Z)10(am)10(pier)-37(i)]TJ /Span<>> BDC ( )Tj EMC 5.805 0 Td [(FM, )0.6(Nak)-17(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 6.339 0 Td [(H)49(A. )0.6(Nega)15(t)-32(i)-16(ve )0.6(p)25(r)-24(essur)-23.9(e )]TJ 0.137 Tw -18.204 -1.25 Td [(w)-14(ound )0.6(t)-13(her)-33(apy )0.6(in )0.5(com)10(ple)-18(x )0.6(tr)-33(auma )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 15.823 0 Td [(per)-37(ineum. )]TJ /T1_1 1 Tf 4.49 0 Td [(R)21(evisto )0.6(do )0.5(Colegio )]TJ 0.023 Tw -20.313 -1.25 Td [(Brasiler)-36.9(io. Cirugioes. )]TJ /T1_0 1 Tf 0 Tw (2013;40$4$:312\226317.)Tj 0.063 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\204\017\b\026\005\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\215., \212\026\027\017\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \217\t\002\026\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\200. \217\026\027\036\027\017\016 \016\020\024\007\017\004)Tj 0 Tw (-)Tj -0.005 Tw -1.796 -1.25 Td (\027\024\005 \024\002\035\026\f\021\017. )Tj /T1_1 1 Tf (\215\016\024\035\020\022\021 \001\022\033\023\033\013\022\022 \022\b. \235\ .\235.)Tj /Span<>> BDC ( )Tj EMC (\231\033\016\021\034\036\037.)Tj /T1_0 1 Tf ( 2006;1:101\226106. )Tj 0.068 Tw T* [(/ Mikhail)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.P., Danil)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.M., R)-20(ybakov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.V. Injur)-37(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he gl)35(uteal )]TJ 0 Tw 29.055 35 Td [(r)-24(egion. )]TJ /T1_1 1 Tf 0.044 Tw 3.177 0 Td (Bulletin of)Tj /Span<>> BDC ( )Tj EMC [(Surg)12.1(er)-43(y named af)-46(ter I.I.)]TJ /Span<>> BDC ( )Tj EMC [(Grek)13(ov.)]TJ /T1_0 1 Tf ( 2006;1:101\226106. )Tj 0.023 Tw -3.177 -1.25 Td ($in Russ.$.)Tj 0.261 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Navsar)-36.9(ia)]TJ /Span<>> BDC ( )Tj EMC (PH, Edu)Tj /Span<>> BDC ( )Tj EMC (S, Nicol)Tj /Span<>> BDC ( )Tj EMC [(AJ. Ci)-16(v)-16(il)-30.9(ian e)-18(xtr)-33(aper)-36.9(i)-24(t)17(oneal r)-23.9(ec)-16(t)15(al )]TJ 0.061 Tw -1.796 -1.25 Td [(gunsho)17(t w)-14(ounds: sur)-32(gical mana)-17(gement made sim)10(pler. )]TJ /T1_1 1 Tf [(W)29(orld Jour)-14(nal )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y)]TJ /T1_0 1 Tf (. 2007;31:1345\2261351.)Tj 0.014 Tc 0.506 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.851 0 Td [(\025\035\017\027\017\004\036\f\022\017\036 )0.6(\030\036\022\024\n\036\027\007\026\006\017\017. )0.5(\203\036\007\024\f\021\026\021\024\004\027\024\f\021\034 )0.6(\026\027\026\035\034\027\024\020\024)14( )]TJ 0 Tc 0.099 Tw -1.851 -1.25 Td [(\f\235\017\027\022\021\036\030\026. 2021; 61 \f. / Cl)-30.9(inical guidel)-30.9(ines. Anal sphinc)-15.9(ter insuf)]TJ 0 Tw (-)Tj 0.023 Tw T* [(f)-28(ic)-24(iency. 2021; 61 p. $in Russ.$.)]TJ 0.281 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \215\024\007\n\026\030\036\027\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\214.\205., \215\024\035\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\203., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.34 Tw -1.796 -1.25 Td (\217\024\035\034 \220\035\036\022\021\030\024\n\017\024\020\030\026\235\017\ \017 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\036 )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\024\020\024 \f\024\f\021\ \024\016\027\017\016 )]TJ 0.258 Tw T* (\026\023\017\030\026\021\036\035\034\027\024\020\024 \026\023\023\026\030\ \026\021\026 \023\030\016\n\024\005 \022\017\001\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\005 )Tj 0.004 Tc -0.004 Tw T* (\017\027\022\024\027\021\017\027\036\027\006\017\036\005. )Tj /T1_1 1 Tf 0.349 Tw 7.836 0 Td (\233\023\020\021\006\022\034\020\037\027\007\020\037\030 \005\022\037\013\ \020\034\024\035\022\021\037)Tj /T1_0 1 Tf [(. 2006;1:57\22667.)4.1( )]TJ 0 Tc 0.168 Tw -7.836 -1.25 Td [(/ F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(O.Y)35(u., P)10(odmar)-23.9(enkov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.F., P)10(ole)-12(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(N.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole )]TJ 0.129 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(elec)-16(tr)-32(omyo)-15.9(gr)-33(aphy in assessing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(func)-16(t)-32(ional st)15(a)15(te of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he l)30(o)-16(ck)]TJ 0 Tw 27.286 0 Td (-)Tj 0.225 Tw -27.286 -1.25 Td [(ing app)32(ar)-33(a)15(tus of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he r)-24(ec)-16(tum in p)32(a)15(t)-32(ients wi)-23.9(t)-13(h anal incont)-32(inence. )]TJ /T1_1 1 Tf 0.023 Tw T* [(F)24(unctional diagnostics.)]TJ /T1_0 1 Tf ( 2006;1:57\22667. $in Russ.$.)Tj 0.012 Tc 0.425 Tw T* [(3)0.5(1)0.5(.)]TJ /Span<>> BDC 1.33 0 Td ( )Tj EMC 0.511 0 Td [(\221)0.5(\036)0.5(\035)0.5(\t)0.5(\020)0.5(\017)0.5(\027)]TJ /Span<>> BDC 3.853 0 Td ( )Tj EMC [(\222)0.5(.)0.5(\202)0.5(.)0.5(,)0.5( \215)0.5(\024)0.5(\035)0.5(\036)0.5(\021)0.5(\024)0.5(\r)]TJ /Span<>> BDC 7.007 0 Td ( )Tj EMC [(\203)0.5(.)0.5(\203)0.5(.)0.5(,)0.5( \203)0.5(\036)0.5(\b)0.5(\030)0.5(\017)0.5(\022)0.5(\024)0.5(\r)0.5(\026)]TJ /Span<>> BDC 7.941 0 Td ( )Tj EMC [(\225)0.5(.)0.5(\200)0.5(.)0.5(,)0.5( \017)]TJ /Span<>> BDC 3.718 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.5(\r)0.5(\021)0.5(.)12( )]TJ 0.018 Tc 0.651 Tw -24.36 -1.25 Td (\217\036\031\035\034\021\026\021\t \020\030\026\006\017\035\024\023\035\ \026\f\021\017\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\024\005 \027\036\007\024\f\021\026\021\024\004\027\024\f\ \021\017)18( )]TJ 0 Tc 0.194 Tw T* (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026.\ )Tj /T1_1 1 Tf 0 Tw (\214\022\033\023\033\013\022\030)Tj /T1_0 1 Tf 0.194 Tw [(. 2007;7:45\22650. / S)-16(hel)35(ygin Y)35(u.A., )]TJ 0.079 Tw T* [(P)10(ole)-12(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(N.N., Nekhr)-36.9(ikov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(S.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(gr)-33(a)-17(c)-24(il)30(opl)-15.9(ast)-10(y in case )]TJ 0.233 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(ple)-12(te anal sphinc)-15.9(ter insuf)-56(f)-28(ic)-24(iency. )]TJ /T1_1 1 Tf 0 Tw [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.233 Tw (. 2007;7:45\22650. )Tj 0.023 Tw T* ($in Russ.$.)Tj 0.098 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\222., \224\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\222., \215\024\035\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\203., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\024\030\030\036\022\006\017\016 )Tj 0.008 Tw -1.796 -1.25 Td (\027\036\005\030\024\n\024\021\024\030\027\024\005 \235\031\027\022\006\017\ \017 \027\036\032\027\024\005 \n\t\001\006\t \002\036\007\030\026 \023\024\ \f\035\036 \020\030\026\006\017\035\024\023\035\026)Tj 0 Tw (-)Tj T* (\f\021\017\022\017. )Tj /T1_1 1 Tf 2.918 0 Td (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_0 1 Tf 0.076 Tw [(. )0.6(2014;4:45\22650. )0.6(/ )0.6(F)9.9(omenko)]TJ /Span<>> BDC ( )Tj EMC 18.948 0 Td [(O.Y)35(u., )0.6(T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC 4.922 0 Td (A.)Tj 0.162 Tw -26.788 -1.25 Td [(Y)35(u., P)10(ole)-12(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(N.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cor)-24(r)-24(ec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(neur)-31.9(omo)17(t)17(or func)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.275 Tw T* [(gr)-33(a)-17(c)-24(il)-30.9(is muscle of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he t)-12.9(high af)-28(ter gr)-32.9(a)-17(c)-24(il)30(opl)-16(ast)-10(y. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46.1(roktologia. )]TJ /T1_0 1 Tf 0.023 Tw T* (2014;4:45\22650. $in Russ.$.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7653 56.0378 Tm (122)Tj ET endstream endobj 464 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 343.4568 42.7216 Tm [(Sur)31(ger)-30.9(y of militar)-31(y injuries of th)11(e perineum $r)31(e)11(vie)11(w$)]TJ -40.125 0 Td [(\224\b\017\220\017\020\b\213\f\205\007\005 \026)11(\005\007)-10(\026\b\007\005 \013\f\213\f\t\b \223\005\216\b\f\t\026)11.1(\025\016 \205\022\210\025\f\016\240\024\b )]TJ 0 -1 TD [(\017\005\t\f\t\b\024\b \223\017\025\024\f\235\t\025\205)-10(\026\b $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-19.9(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.17 Tw 10 0 0 10 42.5197 724.8299 Tm [(\017\n\036\027\036\027\017\005; )0.5(\027\026\035\017\004\017\036 \024\032\024\020\024\r \023\024\r\030\036\032\ \007\201\027\027\t\b \021\022\026\027\036\005; )]TJ 0.01 Tw 0 -1.218 TD (\022\026\022 \023\030\026\r\017\035\024, \027\026\035\017\004\017\036 \021\ \016\032\201\035\t\b \f\024\023\031\021\f\021\r\031\033\013\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n)Tj 0 Tw (-)Tj 0.059 Tw T* (\002\017\027\017\030\024\r\026\027\027\t\b \023\024\r\030\036\032\007\036\ \027\017\005. \237\021\017 \024\f\024\002\036\027\027\024\f\021\017 \024\ \023\030\036)Tj 0 Tw (-)Tj -0.046 Tw T* (\007\036\035\016\033\021 \027\036\024\002\b\024\007\017\n\024\f\021\034 \ \024\f\024\002\024\005 \021\026\022\021\017\022\017 \b\017\030\031\030\020\ \017\004\036\f\022\024)Tj 0 Tw (-)Tj T* (\020\024 \035\036\004\036\027\017\016 \002\024\036\r\t\b \030\026\027\036\ \027\017\005 \023\030\024\n\036\032\027\024\f\021\017.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\226\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.153 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \201)8.8(\016)-0.9(\033\016)-26(\001)4.7(\034\005)1.9(\034)9.7(\036)]TJ /Span<>> BDC ( )Tj EMC [(\002)-2.1(.)29.4(\222)28.7(.)7.9(, )]TJ -0.01 Tc 0.01 Tw T* [(\211)-10.5(\020\020\022\006)-7.3(\016)-3.4(\036)]TJ /Span<>> BDC 3.418 0 Td ( )Tj EMC [(\235)18.8(.)20.3(\205)12.9(.)]TJ /T1_1 1 Tf 0 Tc 0.87 Tw -3.418 -1.218 Td [(\225)-4.6(\002)-9.9(\024)0.7(\030 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.712 0 Td [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 )0.6(\n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf [( )0.5(\r)15.6(\034)14.2(\031)-1.2(\027)3.3(\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC 15.673 0 Td [(\222)28.8(.)43.7(\002)-2.1(.)7.8(, )]TJ -0.01 Tc 0.01 Tw -20.384 -1.218 Td [(\r)25.3(\023)-14.2(\031\007)-4.5(\b\022)-2.8(\020)-6.2(\034\036)]TJ /Span<>> BDC 4.261 0 Td ( )Tj EMC [(\213)-12.3(.)-19.6(\203)-8.5(.)]TJ /T1_1 1 Tf 0.018 Tc 1.895 Tw -4.261 -1.218 Td [(\225)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_3 1 Tf 0 Tc 1.913 Tw 13.262 0 Td [( \r)15.6(\034)14.2(\031)-1.3(\027)3.3(\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\222)28.8(.)43.7(\002)-2.1(.)7.8(, )]TJ -0.01 Tc 0.01 Tw -13.262 -1.218 Td [(\r)25.3(\023)-14.2(\031\007)-4.5(\b\022)-2.8(\020)-6.2(\034\036)]TJ /Span<>> BDC 4.261 0 Td ( )Tj EMC [(\213)-12.3(.)-19.6(\203)-8.5(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -4.261 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \211)-10.5(\020\020\022\006)-7.3(\016)-3.4(\036)]TJ /Span<>> BDC 3.651 0 Td ( )Tj EMC [(\235)18.8(.)20.4(\205)12.8(.)-2.2(,)-10( \r)25.3(\023)-14.2(\031\007)-4.5(\b\022)-2.8(\020)-6.2(\034\036)]TJ /Span<>> BDC 6.527 0 Td ( )Tj EMC [(\213)-12.3(.)-19.6(\203)-8.6(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -17.871 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf [( \201)8.8(\016)-0.9(\033\016)-26(\001)4.7(\034\005)2(\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\002)-2.1(.)29.3(\222)28.8(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf -0.001 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d )0.5(d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e )0.5(s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( S)5.6(e)-1.7(r)2.3(g)-2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(N)13(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-1.7(r)2.4(ek)5.4(h)1.9(o)-7.8(d)-1(o)-0.6(v)33.6(, )]TJ -0.005 Tc 0.005 Tw T* [(I)5(g)-7.5(o)-3.7(r)]TJ /Span<>> BDC 1.596 0 Td ( )Tj EMC [(E)14.8(.)]TJ /Span<>> BDC 0.987 0 Td ( )Tj EMC [(O)-10(nn)1.2(i)-4.1(t)-34.1(se)-9(v)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -2.583 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(N)8(i)7.9(k)12.9(o)-1.1(l)3.3(a)-5.8(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)12.3(z)11.1(l)2.9(ov)33.6(, A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(D)24(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)-1.6(z)4.8(m)5.8(i)8.4(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf -0.007 Tc 1.505 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.498 Tw 10.586 0 Td [( N)8(i)7.9(k)13(o)-1.1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.4(o)12.3(z)11.1(l)2.9(o)-0.6(v)33.6(, )]TJ -0.005 Tc 0.005 Tw -10.586 -1.218 Td [(A)-1.4(le)-5.3(k)-22.5(se)-7.5(y)]TJ /Span<>> BDC 2.941 0 Td ( )Tj EMC [(D)18.9(.)]TJ /Span<>> BDC 1.047 0 Td ( )Tj EMC [(K)7.3(u)-6.6(zm)0.8(i)3.4(n)-3.1(o)-5.6(v)]TJ /T1_1 1 Tf 0 Tc -0.067 Tw -3.988 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_3 1 Tf [( I)10(g)-2.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(O)-5(n)5.3(n)6.1(i)1(t)-29.1(s)4.9(e)-4(v)33.6(, A)3.6(l)4.9(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(D)23.9(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)-1.6(z)4.8(m)5.8(i)8.4(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw 23.244 28.009 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf -0.002 Tc 0.002 Tw 3.238 0 Td [( S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.8 0 Td ( )Tj EMC [(N)11(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(P)22(e)-3.7(re)-2.3(k)3.4(ho)-9.8(d)-3(o)-2.6(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -7.125 -2.436 Td (\255\026\036\031\036\025\034\222 \017\225 \032\026\020\017\022\032\233 $\ ORCID$)Tj /T1_1 1 Tf 0.27 Tw T* (\215\036\030\036\b\024\007\024\r \225\036\030\020\036\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \004\035\036\027-\022\024\030\030. \217\202\203, )Tj 0.481 Tw T* [(\007.\n.\027., \023\030\024\235\036\f\f\024\030, )0.5(\026\r\036\007\031\033\013\017\005 \022\026\235\036\007\030\024\005 \020\ \024\f\023\017)]TJ 0 Tw (-)Tj 0.56 Tw T* [(\021\026\035\034\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.39 0 Td [(\r\024\036\027\027\024-\023\024\035\036\r\024\005 )0.6(\b\017\030\031\030\020\017\017 )0.5(\205\206\207\210\211 )0.6(\200\210 )]TJ 0.591 Tw -5.39 -1.218 Td (\253\217\024\f\f\017\005\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\ \021 \n\036\007\017\006\017\027\t\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0001-7166-0290)Tj 0.033 Tw T* (\210\027\027\017\006\036\r \230\020\024\030\034 \213\r\020\036\027\034\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \020\035\026\r\027\t\005 \b\017\030\031\030\020 )Tj 0 Tw T* (\020\024\f\023\017\021\026\035\016; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-3858-2371)Tj -0.02 Tw T* (\025\024\035\024\r \203\017\022\024\035\026\005 \225\036\030\020\036\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 \022\026\235\036\007\030\t \ )Tj 0.094 Tw T* (\020\024\f\023\017\021\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\036\027\027\024-\023\024\035\036\r\024\005 \b\017\030\031\030\020\ \017\017 \205\206\207\210\211 \200\210 )Tj 0.591 Tw 0 -1.218 TD (\253\217\024\f\f\017\005\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\ \021 \n\036\007\017\006\017\027\t\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-0873-1380)Tj -0.067 Tw 0 -1.218 TD [(\025\031\034\n\017\027\024\r )0.6(\202\035\036\022\f\036\005 )0.5(\212\n\017\021\030\017\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 13.334 0 Td [(\227 )0.5(\026\f\023\017\030\026\027\021 )0.5(\022\026\235\036\007\030\t )]TJ 0.094 Tw -13.334 -1.218 Td (\020\024\f\023\017\021\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\036\027\027\024-\023\024\035\036\r\024\005 \b\017\030\031\030\020\ \017\017 \205\206\207\210\211 \200\210 )Tj 0.591 Tw T* (\253\217\024\f\f\017\005\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\ \021 \n\036\007\017\006\017\027\t\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID)Tj /Span<>> BDC ( )Tj EMC (0009-0000-9040-4022)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS $ORCID$)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Ser)-32(ge)-11(y N. P)30.1(er)-24(ekhod)-15.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7166-0290)Tj T* [(Igor E. Onni)-23.9(tsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3858-2371)Tj T* [(Nikol)-16(a)15.1(y S. K)25(ozl)30(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0873-1380)Tj T* [(Alek)-10(se)-10.9(y D. K)25(uzminov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0000-9040-4022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 408.2019 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.124 Tw 8 0 0 8 42.5197 395.3672 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Br)-32(o)-16(gden)]TJ /Span<>> BDC ( )Tj EMC [(T)35(G, JP Gar)-14.9(ner. Anor)-23.9(ec)-16(t)15(al injur)-24(y in pel)30.1(v)-16(ic bl)-16(ast. )]TJ /T1_3 1 Tf 0 Tw [(Jour)-14(nal )]TJ 0.023 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(the ro)12(yal ar)-14(m)11(y medical cor)-17.9(ps.)]TJ /T1_1 1 Tf ( 2013; 159 Suppl 1: p 26-31.)Tj 0.202 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(ossadegh)]TJ /Span<>> BDC ( )Tj EMC [(S, T)40(ai)]TJ /Span<>> BDC ( )Tj EMC [(N, Mid)-17(winter)]TJ /Span<>> BDC ( )Tj EMC [(M. Im)10(p)25(r)-32(ov)-15.9(ised e)-18(xpl)30.1(osi)-16(ve dev)-16(ice )]TJ 0.114 Tw -1.296 -1.25 Td [(r)-24(el)-16(a)15.1(ted pel)30(v)-16(i-per)-36.9(ineal tr)-33(auma: Ana)15(t)17(omic injur)-36.9(ies and sur)-32(gical man)]TJ 0 Tw (-)Tj T* [(a)-17(gement. )]TJ /T1_3 1 Tf 0.221 Tw 4.256 0 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(trauma and acute care surg)12(er)-43(y.)]TJ /T1_1 1 Tf ( 2012; 73$2$, )Tj 0.023 Tw -4.256 -1.25 Td (Suppl.1: 24-31.)Tj -0.025 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(ossadegh)]TJ /Span<>> BDC ( )Tj EMC [(S, Mid)-17(winter)]TJ /Span<>> BDC ( )Tj EMC [(M, P)40(ar)-24(k)10(er)]TJ /Span<>> BDC ( )Tj EMC [(P. Devel)30(oping a)]TJ /Span<>> BDC ( )Tj EMC [(cumul)-15.9(a)15(t)-32(i)-16(ve ana)]TJ 0 Tw (-)Tj 0.077 Tw -1.296 -1.25 Td [(t)17(omic scor)-36.9(ing sy)-13(stem )0.5(for mil)-31(i)-24(t)15.1(ar)-24(y per)-37(ineal )0.5(and pel)30(v)-16(ic bl)-15.9(ast injur)-37(ies. )]TJ /T1_3 1 Tf 0.023 Tw T* [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(the ro)12.1(yal ar)-14(m)11(y medical cor)-17.9(ps.)]TJ /T1_1 1 Tf ( 2013; Suppl 1: i40-4.)Tj -0.011 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(ossadegh)]TJ /Span<>> BDC ( )Tj EMC (S, He)Tj 0 Tw /Span<>> BDC 4.664 0 0 4.664 105.5941 308.0312 Tm ( )Tj EMC -0.011 Tw 8 0 0 8 106.6304 305.3672 Tm [(S, P)40(ar)-23.9(k)9.9(er)]TJ /Span<>> BDC ( )Tj EMC [(P. Ba)15(yesian S)-24(cor)-37(ing Sy)-13(stems for Mil)-30.9(i)-24(t)15(ar)-24(y )]TJ -0.009 Tw -8.014 -1.25 Td [(P)30(el)30(v)-15.9(ic and P)30(er)-37(ineal Bl)-15.9(ast Injur)-37(ies: Is i)-24(t T)35(ime t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(T)40(ak)10(e a)]TJ /Span<>> BDC ( )Tj EMC [(New App)25(r)-31.9(oa)-17(ch? )]TJ /T1_3 1 Tf 0.023 Tw T* [(Militar)-42.9(y medicine.)]TJ /T1_1 1 Tf ( 2016;181,Sup. 5:127\226131.)Tj 0.225 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(har)-16(ma)]TJ /Span<>> BDC ( )Tj EMC [(DM, W)22(ebster)]TJ /Span<>> BDC ( )Tj EMC [(CE, Kir)-23.9(kman-Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(J. Bl)-16(ast injur)-23.9(y t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0 Tw -1.296 -1.25 Td [(per)-37(ineum. )]TJ /T1_3 1 Tf 0.095 Tw 4.449 0 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(the ro)12(yal ar)-13.9(m)11(y medical cor)-18(ps.)]TJ /T1_1 1 Tf ( 2013;159, Suppl )Tj 0 Tw -4.449 -1.25 Td (1:i1\226i3.)Tj 0.119 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-25(gar)-38(w)-11.9(al)]TJ /Span<>> BDC ( )Tj EMC [(H, K)-16(a)15(t)-32(iy)22(ar)]TJ /Span<>> BDC ( )Tj EMC [(A, P)35(r)-37(iy)22(ad)42(ar)-10(shani)]TJ /Span<>> BDC ( )Tj EMC [(P. Ma)-17(gni)-24(tude and outcomes )]TJ 0.067 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(ple)-18(x per)-37(ineal injur)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC (\227 A)Tj /Span<>> BDC ( )Tj EMC [(r)-23.9(e)-12(tr)-32(ospec)-16(t)-32(i)-16(ve anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(f)-27.9(i)-16(ve year)-10(s\241 )]TJ 0.048 Tw T* [(d)42(a)15(t)15(a fr)-32(om a)]TJ /Span<>> BDC ( )Tj EMC [(L)35(evel 1 tr)-33(auma centr)-23.9(e. )]TJ /T1_3 1 Tf [(T)56.1(ropical Doctor)]TJ /T1_1 1 Tf (. 2021;51$3$:344\226)Tj 0 Tw T* (349.)Tj 0.151 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Gl)-16(asgo)-13.9(w)]TJ /Span<>> BDC ( )Tj EMC 3.691 0 Td [(SC, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.713 0 Td [(al. )0.6(Ini)-24(t)-32(ial )0.6(mana)-17(gement )0.6(and )0.5(outcome )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 16.901 0 Td [(moder)-15(n )]TJ 0.023 Tw -24.601 -1.25 Td [(ba)15(t)-30(tlef)-27.9(ield anal tr)-32.9(auma. )]TJ /T1_3 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf ( 2014;57$8$:1012\2261018.)Tj 0.245 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Car)-30(l)30(os VR Br)-32(o)-14(wn, P)30(edr)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(G. Contem)10(por)-32.9(ar)-24(y mana)-16.9(gement of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)]TJ 0 Tw (-)Tj 0.177 Tw -1.296 -1.25 Td [(t)15(al injur)-36.9(ies a)15(t L)35(evel I tr)-32.9(auma center)-9.9(s: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC [(an Amer)-37(ican )]TJ 0.272 Tw T* [(Asso)-16(c)-23.9(ia)15(t)-32(ion for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Sur)-32(ger)-23.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(T)50(r)-33(auma mul)56(t)-32(i-inst)-31.9(i)-24(tut)-32(ional stud)17(y. )]TJ /T1_3 1 Tf 0.023 Tw T* [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(T)56(rauma and Acute Care Surg)12(er)]TJ /T1_1 1 Tf (. 2018;84$2$:225\226233.)Tj 0.188 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(us)26(minsk)-31.9(y)]TJ /Span<>> BDC ( )Tj EMC [(RE, S)-16(hbeeb)]TJ /Span<>> BDC ( )Tj EMC (I, Makos)Tj /Span<>> BDC ( )Tj EMC [(G. Bl)35(unt pel)30(v)-16(iper)-36.9(ineal injur)-36.9(ies. )]TJ 0.079 Tw -1.296 -1.25 Td (An)Tj /Span<>> BDC ( )Tj EMC [(e)-18(xp)32(anded r)-32(ole for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(di)-16(ver)-21.9(t)-32(ing col)30(ost)17(omy. )]TJ /T1_3 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the colon )Tj 0.023 Tw T* (and rectum.)Tj /T1_1 1 Tf ( 1982;25$8$:787\226790.)Tj 0.031 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Oster)-23.9(ber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(EC, V)30(ei)-24(t)-13(h)]TJ /Span<>> BDC ( )Tj EMC [(J, Car)-30(l)30(os)]TJ /Span<>> BDC ( )Tj EMC [(VR. Concomi)-23.9(t)15(ant bl)-16(adder and r)-24(ec)-16(t)15(al )]TJ 0.001 Tw -1.796 -1.25 Td [(injur)-23.9(es: r)-24(esul)56(ts fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Amer)-36.9(ica Asso)-16(c)-24(ia)15(t)-32(ion for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(ger)-23.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-32.9(au)]TJ 0 Tw (-)Tj 0.045 Tw T* [(ma )0.5($AA)35(S)-20.9(T$ )0.5(mul)56(t)-32(i-center )0.6(r)-24(ec)-16(t)15.1(al )0.5(injur)-24(y )0.6(stud)17(y )0.5(gr)-32(oup. )]TJ /T1_3 1 Tf 20.445 0 Td [(Jour)-13.9(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.33 0 Td [(T)56(rauma )]TJ 0.023 Tw -24.775 -1.25 Td [(and Acute Care Surg)12(er)]TJ /T1_1 1 Tf (. 2019 88$2$:286\226291.)Tj 0.006 Tc 0.349 Tw 29.055 38.75 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.82 0 Td (\225\026\035\026\026\030 \204\031\027\034\024\f)Tj /Span<>> BDC ( )Tj EMC (\207.\202. \230\f\023\024\035\034\024\r\026\027\017\036 \024\021\030\017\ \006\026\021\036\035\034\027\024\020\024 \007\026\r)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.349 Tw -1.82 -1.25 Td [(\035)0.5(\036)0.6(\027)0.5(\017)0.5(\016)0.5( \023)0.5(\030)0.6(\017)]TJ /Span<>> BDC 4.56 0 Td ( )Tj EMC [(\035)0.5(\036)0.5(\004)0.5(\036)0.6(\027)0.5(\017)0.5(\017)0.6( \026)0.5(\027)0.6(\026)0.5(\220)0.5(\030)0.5(\024)0.6(\002)0.5(\027)0.5(\024)0.6(\005)0.5( \027)0.6(\036)0.5(\022)0.5(\035)0.5(\024)0.6(\f)0.5(\021)0.5(\030)0.5(\017)0.6(\007)0.5(\017)0.5(\026)0.5(\035)0.6(\034)0.5(\027)0.5(\024)0.6(\005)0.5( \017)0.6(\027)0.5(\235)0.5(\036)0.6(\022)0.5(\006)0.5(\017)0.6(\017)2( )]TJ 0.011 Tc -0.011 Tw -4.56 -1.25 Td (\023\030\024\n\036\032\027\024\f\021\017. )Tj /T1_3 1 Tf 0.413 Tw 6.632 0 Td (\244\023\033\020\037\027 \022\b\016\020\022 \f\033\034\017\016\024\024\034\ \033\037. \230.\240.)Tj /Span<>> BDC ( )Tj EMC (\r\034\024\035\026\n\020\021\037.)Tj /T1_1 1 Tf 0 Tc 0 Tw 21.006 0 Td ( )Tj 0.174 Tw -27.638 -1.25 Td [(2021;8$3$:42\22645. )0.5(/ Sal)-16(a)-24(zar )0.5(Munoz)]TJ /Span<>> BDC ( )Tj EMC [(B.A. T)47(he)]TJ /Span<>> BDC ( )Tj EMC 18.681 0 Td [(use )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(nega)15(t)-32(i)-16(ve )0.5(p)25(r)-24(es)]TJ 0 Tw (-)Tj 0.118 Tw -18.681 -1.25 Td [(sur)-23.9(e in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(anaer)-31.9(obic non-cl)30(ostr)-37(idial infec)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0 Tw T* [(per)-37(ineum. )]TJ /T1_3 1 Tf 0.302 Tw 4.656 0 Td (The)Tj /Span<>> BDC ( )Tj EMC [(jour)-13.9(nal named af)-45.9(ter Professor)]TJ /Span<>> BDC ( )Tj EMC (B.M.)Tj /Span<>> BDC ( )Tj EMC [(K)18(ostyuchenk)11.1(a.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw -4.656 -1.25 Td (2021;8$3$:42\22645. $in Russ.$.)Tj -0.03 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\212\026\r\017\007\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\212.\214., \225\024\035\024\n\022\026)Tj /Span<>> BDC ( )Tj EMC (\202.\254. \207\031\030\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\202.\025. \025\017\027\017\004\036\f\022\017\005 \f\035\031)Tj 0 Tw (-)Tj 0.022 Tw -1.796 -1.25 Td (\004\026\005: \210\f\021\030\t\005 \023\026\030\026\023\030\024\022\021\017\ \021, \235\035\036\020\n\024\027\026 \205\031\030\027\034\036. \217\026\007\ \017\022\026\035\034\027\024\036 \035\036\004\036\027\017\036 )Tj 0.083 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\024\005 \030\026\027\t \023\030\024\n\036\032\ \027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\001\024\027\022\017. \025\035\017\027\017\004\036\f\022\017\005 \f\ \035\031\004\026\005. )Tj /T1_3 1 Tf 0.295 Tw T* [(\r\027\022\020\022\n\016\024\021\037\030 )0.5(\f\033\037\021\035\022\021\037.)]TJ /T1_1 1 Tf [( 2022;13$3$:101\226108. / Dav)-16(id)-16(ov)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC (D.L., )Tj 0.346 Tw T* [(S)-16(ol)30(omk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)50(a. Bur)-32(ovsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(A.K. Cl)-31(inical case: A)-25(cute p)32(ar)-32.9(ap)25(r)-32(o)-16(c)-16(t)-32(i)-24(t)-32(is, )]TJ 0.113 Tw T* [(F)10(our)-15(nier\241s phlegmon. R)-10(adical tr)-24(ea)15(tment wi)-23.9(t)-13(h pl)-15.9(ast)-32(ic sur)-31.9(ger)-24(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ -0.014 Tw T* [(w)-14(ound of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he per)-37(ineum and scr)-32(o)17(tum. A)]TJ /Span<>> BDC ( )Tj EMC [(cl)-31(inical case. )]TJ /T1_3 1 Tf [(Clinical p)45.9(ractice.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2022;13$3$:101\226108. $in Russ.$.)Tj 0.209 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\036\021\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\225.\203. \210\002\013\026\016 \b\017\030\031\030\020\017\016. \204\024\ \f\022\r\026: \206\237\210\224\202\217-\204\036\007\017\026. 2014; )Tj 0.04 Tw -1.796 -1.25 Td [(\f.832. / P)30(e)-12(tr)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.N. Gener)-33(al sur)-32(ger)-24(y. M)-24(osco)-13.9(w: GEOT)35(AR-Media. 2014; )]TJ 0.023 Tw T* (p.83. $in Russ.$.)Tj 0.081 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\240\017\007\022\024\r)Tj /Span<>> BDC ( )Tj EMC 3.576 0 Td [(\225.\202., )0.5(\221\027\017\021\022\024)]TJ /Span<>> BDC ( )Tj EMC 5.611 0 Td [(\225.\203. )0.5(\200\024\036\027\027\024-\023\024\035\036\r\026\016 )0.6(\b\017\030\031\030\020\017\016. )0.5(\206\030\024\007\027\024: )]TJ 0.002 Tw -10.982 -1.25 Td [(\206\030\206\204\211. )0.5(2001; 356 \f. )0.5(/ Zhidkov)]TJ /Span<>> BDC ( )Tj EMC 12.356 0 Td [(S.A. )0.5(Sni)-24(tko)]TJ /Span<>> BDC ( )Tj EMC [(S.N. )0.5(Mil)-31(i)-23.9(t)15(ar)-24(y )0.5(f)-28(ield sur)-32(ger)-23.9(y. )]TJ 0.023 Tw -12.356 -1.25 Td [(G)20(r)-32(odno: G)20(r)-32(gmu. 2001; 356 p. $in Russ.$.)]TJ 0.296 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\031\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\230. \213\030\026\f\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204. \212\r\024\030\016\027\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200. \224\030\026\r\n\026 \023\030\016\n\024\005 )Tj 0.001 Tc 0.35 Tw -1.796 -1.25 Td [(\022\017\001\022\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 4.275 0 Td [(\n\017\030\027\024\036 )0.5(\r\030\036\n\016. )]TJ /T1_3 1 Tf 7.03 0 Td [(\215\016\024\035\020\022\021 )0.6(\002\201\025\231\207 )0.5(\002\016\033\022\030 )0.5(11. )0.5(\240\016\005\022\006\022\020\037)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.343 Tw -11.305 -1.25 Td [(2013;1:127\226133. )0.6(/ )0.6(S)-16(hugaev)]TJ /Span<>> BDC ( )Tj EMC 12.518 0 Td [(A.I., )0.6(Er)-33(ast)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC 5.818 0 Td [(A.M., )0.6(Dvor)-24(y)22(ank)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC 7.654 0 Td (D.V. )Tj 0.049 Tw -25.99 -1.25 Td [(T)50(r)-33(auma t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he head in pea)-17(ce)-12(t)-32(ime. )]TJ /T1_3 1 Tf [(V)33(estnik Spbsu Ser)-37(ies 11. Medicine)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2013;1:127\226133. $in Russ.$.)Tj 0.139 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-24(ent Emigh, K)25(enji Inaba, M)-24(or)-31.9(gan S)-24(chellenber)-31.9(g. Contem)10(por)-33(ar)-24(y )]TJ 0.17 Tw -1.796 -1.25 Td [(dia)-17(gnosis )0.5(and )0.5(mana)-17(gement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 12.951 0 Td [(tr)-33(auma)15.1(t)-32(ic )0.5(r)-24(ec)-16(t)15(al )0.5(injur)-23.9(es. )]TJ /T1_3 1 Tf 10.561 0 Td [(Surg)12(er)-43(y )0.5(in )]TJ 0.023 Tw -23.512 -1.25 Td [(p)46(ractice and science.)]TJ /T1_1 1 Tf [( 2021; V)29(ol. 8, Ar)-21.9(t)-32(icle 100024.)]TJ 0.221 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Daniel O )0.5(Her)-24(zig. Car)-23.9(e of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )0.5(P)40(a)15(t)-32(ient wi)-24(t)-12.9(h Anor)-24(ec)-16(t)15.1(al T)50(r)-33(auma. )]TJ /T1_3 1 Tf 0.023 Tw -1.796 -1.25 Td [(Clinics in Colon and R)21(ectal Surg)12(er)-42.9(y.)]TJ /T1_1 1 Tf ( 2012;25:210\226213.)Tj 0.229 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(teele)]TJ /Span<>> BDC ( )Tj EMC [(SR, W)20(ol)16(co)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC (KE, Mullenix)Tj /Span<>> BDC ( )Tj EMC [(PS. Col)30(on and r)-23.9(ec)-16(t)15(al injur)-37(ies )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 504.6522 56.0378 Tm (121)Tj ET endstream endobj 55 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 56 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 57 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 58 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 59 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 478 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.346 Tw 10 0 0 10 70.8661 724.8299 Tm (\002\026\022\021\036\030\017\026\035\034\027\024\005 \024\002\f\036\n\036\ \027\201\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004\001\036\027\017\016 \022\030\024)Tj 0 Tw (-)Tj 0.168 Tw 0 -1.218 TD [(\r\024\024\002\030\026\013\036\027\017\016 [27]. \237\235\235\036\022\021\ \017\r\027\024\f\021\034 \023\030\017\n\036\027\036\027\017\016 V)37(A)16(C )]TJ -0.026 Tw T* (\f\017\f\021\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\f\f\017\r\027\t\n\017 \030\026\027\036\027\017\016\n\017, \030\026\ \030\031\001\036)Tj 0 Tw (-)Tj 0.012 Tw T* (\027\017\016\n\017 \023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \027\036 )Tj 0 Tw T* (\030\026\f\f\n\026\021\030\017\r\026\036\021\f\016.)Tj /T1_1 1 Tf 0 -2.436 TD (\017\217\f\002\202\b\r\b\t\235 \212\002\217\f\r \006\004\b\r\b\t\005 \212\ \006\002\214\r\202\b\002\217\003\t)Tj /T1_0 1 Tf 0.148 Tw 0 -1.218 TD (\215\024\f\035\036 \030\026\027\036\027\017\005 \023\030\024\n\036\032\027\ \024\f\021\017, \023\024\035\031\004\036\027\027\t\b \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tw (-)Tj 0.186 Tw T* (\036\027\027\024\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \n\017\030\027\024\036 \r\030\036\n\016, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\201\027\027\024\n \023\024\f\035\036)Tj 0 Tw (-)Tj 0.514 Tw T* (\024\023\036\030\026\006\017\024\027\027\024\n \023\036\030\017\024\007\036\ \r\024\027\017\022\026\033\021 \021\026\022\017\036 \024\f\035\024\032\ )Tj 0 Tw (-)Tj 0.331 Tw T* (\027\036\027\017\016 \022\026\022: \027\036\007\024\f\021\026\021\024\004\ \027\024\f\021\034 \026\027\026\035\034\027\024\020\024 \f\235\017\027\022\ \021\036\030\026, )Tj 0.064 Tw T* (\f\021\030\017\022\021\031\030\t \023\030\016\n\024\005 \022\017\001\022\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, \f\r\017\013\ \017 )Tj 0.125 Tw 0 -1.218 TD [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, \030\031\002\006\024\r\t\036 \017\n\036\027\036\027\ \017\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \023\030\024)Tj 0 Tw (-)Tj 0.487 Tw 0 -1.218 TD [(\n\036\032\027\024\f\021\017, )0.6(\030\036\022\021\024\r\036\017\022\026\035\034\027\t\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.532 0 Td (\030\036\022\021\024\031\030\036\021\030\026\035\034\027\t\036 )Tj 0.371 Tw -14.532 -1.218 Td (\f\r\017\013\017)Tj /Span<>> BDC ( )Tj EMC ([6,16,17,20,21,28]. \200)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \017\f\021\024\004\027\017)Tj 0 Tw (-)Tj 0.181 Tw 0 -1.218 TD (\022\024\r \027\036)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\t\r\026\036\021\f\016 \004\026\f\021\024\021\026 \r\024\027\ \017\022\027\024\r\036\027\017\005 \007\026\027\027\t\b )Tj 0.285 Tw T* (\024\f\035\024\032\027\036\027\017\005. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \027\036\022\024\021\024\030\t\b \017\f\f\035\036\007\ \024\r\026\027\017\005, )Tj 0.159 Tw T* (\023\024\f\035\036 \030\026\027\036\027\017\005 \023\030\016\n\024\005 \022\ \017\001\022\017 \f\021\030\017\022\021\031\030\t \r\024\027\017\022\026\ \035\017 )Tj 0.033 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (20%, \f\r\017\013\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (2,2\22631% \f\035\031\004\026\036\r [28]. \231\026\013\036 \r\f\036\020\024\ )Tj 0.071 Tw T* (\024\002\f\031\032\007\026\036\021\f\016 \027\036\007\024\f\021\026\021\024\ \004\027\024\f\021\034 \f\235\017\027\022\021\036\030\027\024\020\024 \026\ \023\023\026\030\026)Tj 0 Tw (-)Tj T* (\021\026 \023\030\016\n\024\005 \022\017\001\022\017 [6,16,17,20,21].)Tj 0.002 Tc 0.325 Tw T* (\215\024\f\035\036 \030\026\027\036\027\017\005 \023\030\024\n\036\032\027\ \024\f\021\017 \030\036\022\024\n\036\027\007\024\r\026\027\024 \023\030\ \024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.287 Tw T* [(\r\024\007\017\021\034 \024\006\036\027\022\031 \235\031\027\022\006\017\ \017 \f\235\017\027\022\021\036\030\026 \023\030\016\n\024\005 \022\017\001\ \022\017)2( )]TJ 0.296 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \220\027\007\024\030\036\022\021\026\035\034\027\ \024\005 \n\026\027\024\n\036\021\030\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\031)2( )]TJ 0.299 Tw T* (\f\021\030\031\022\021\031\030\t \f\235\017\027\022\021\036\030\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \220\027\007\024\030\036\022\021\026\035\034\027\ \024\020\024)2( )]TJ 0.305 Tw T* [(\211\003\230 [29,30]. \210\022\024\027\004\026\021\036\035\034\027\031\033\ \024\006\036\027\022\031 \f\235\017\027\022\021\036\030\027\024\020\024\ )2( )]TJ 0.203 Tw T* [(\026\023\023\026\030\026\021\026 )0.5(\f\035\036\007\031\036\021 )0.5(\023\030\024\r\024\007\017\021\034 )0.5(\023\024\f\035\036 )0.6(\023\024\035\027\024\020\024 )0.5(\026\032\017\r)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.033 Tw T* [(\035\036\027\017\016 )0.5(\030\026\027\t, \021\026\022 )0.5(\022\026\022 \f\235\024\030\n\017\030\024\r\026\r\001\017\036\f\016 )0.5(\030\031\002\006\t \n\024\020\031\021)2( )]TJ -0.028 Tw T* (\027\026\030\031\001\026\021\034 \036\020\024 \235\031\027\022\006\017\033\ [20]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\017 \027\036\007\024\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.137 Tw T* (\021\024\004\027\024\f\021\017 \026\027\026\035\034\027\024\020\024 \f\235\ \017\027\022\021\036\030\026 \030\026\035\017\004\027\t\n\017 \026\r\021\ \024\030\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.159 Tw T* [(\n\017 )0.5(\030\036\022\024\n\036\027\007\031\036\021\f\016 )0.5(\022\024\027\f\036\030\r\026\021\017\r\027\026\016 )0.5(\021\036\030\026\023\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 19.678 0 Td (\023\024\n\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.135 Tw -19.678 -1.218 Td (\013\034\033 \023\030\024\021\017\r\024\007\017\026\030\036\005\027\t\b \ \023\030\036\023\026\030\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\207\210\225-\021\036\030\026\023\017\017.)2( )]TJ 0.842 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \030\036\022\024\ \n\036\027\007\031\033\021 \023\030\024\r\024\007\017\021\034)2( )]TJ 0.376 Tw T* (\030\026\035\017\004\027\t\036 \023\035\026\f\021\017\004\036\f\022\017\ \036 \024\023\036\030\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\235\017\027\022\021\036\030\036,)2( )]TJ 0.239 Tw T* (\031\f\021\026\027\024\r\022\031 \017\f\022\031\f\f\021\r\036\027\027\024\ \020\024 \f\235\017\027\022\021\036\030\026 \017\035\017 \f\021\017\n\031\ \035\016)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.385 Tw T* [(\006\017\033 \027\036\030\r\024\r \022\030\036\f\021\006\024\r\024\020\024\ \f\023\035\036\021\036\027\017\016 [17,20,31,32].)2( )]TJ 0.553 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\f\f\017\r\027\t\b \023\024\r\030\036\032\007\036\027\017\016\b \f\ \235\017\027\022\021\036\030\026, \022\024\021\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.231 Tw T* (\030\t\036, \022\026\022 \023\030\026\r\017\035\024, \024\023\030\036\007\ \036\035\016\033\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\027\017\b \220\021\026\023\026\b)2( )]TJ 0.438 Tw T* [(\007\017\026\020\027\024\f\021\017\022\017, \030\036\022\024\n\036\027\007\ \024\r\026\027\026 \220\022\f\021\017\030\023\026\006\017\016 \023\030\016\ \n\024\005)2( )]TJ 0 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC ([20].)Tj 0.016 Tc 0.087 Tw T* (\217\036\022\021\024\r\036\017\022\026\035\034\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\031\030\036\021\030\026\035\034\027\t\036 \f\r\017\013\ \017 \r\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.045 Tw T* (\027\017\022\026\033\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\027\024\n \023\024\r\030\036\032\007\036\027\017\ \017 \023\030\016\n\024\005 \022\017\001)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.307 Tw T* (\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r \n\024\004\036\023\024\035\024\r\024\005 \f\017\ \f\021\036\n\t. \200)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\036)16( )]TJ 0.474 Tw T* [(\023\030\024\235\017\035\026\022\021\017\022\017 \017\027\021\030\026\024\ \023\036\030\026\006\017\024\027\027\024\020\024 \024\002\030\026\024\r\ \026\027\017\016)16( )]TJ 0.394 Tw T* (\021\026\022\017\b \f\r\017\013\036\005 \024\023\017\f\t\r\026\036\021\f\ \016 \031\f\021\026\027\024\r\022\026 \f\026\035\034\027\017\022\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.339 Tw T* (\r\024\020\024 \035\024\f\022\031\021\026 \n\036\032\007\031 \023\030\016\ \n\024\005 \022\017\001\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\004\036\r\t\n)16( )]TJ 0 Tw T* (\023\031\t\030\201\n)Tj /Span<>> BDC ( )Tj EMC ([16].)Tj 0 Tc 0.32 Tw T* [(\230\f\023\024\035\034\024\r\026\027\017\036 V)37(A)16(C-\023\024\r\016\024\022 \n\024\032\036\021 \030\026\f\f\n\026\021\030\017\ \r\026\021\034)]TJ 0 Tw (-)Tj 0.097 Tw T* (\f\016 \022\026\022 \023\030\024\235\017\035\026\022\021\017\022\026 \024\ \002\030\026\024\r\026\027\017\005 \020\030\031\002\t\b \030\031\002\006\ \024\r\t\b )Tj 0.049 Tw T* (\017\n\036\027\036\027\017\005 \023\024\f\035\036 \024\002\001\017\030\027\ \t\b \007\036\235\036\022\021\024\r \n\016\020\022\017\b \021\022\026\027\ \036\005 )Tj 0.111 Tw T* [(\023\030\024\n\036\032\027\024\f\021\017. V)37(A)16(C-\023\024\r\016\022\017 \031\f\022\024\030\016\033\021 \235\024\030\n\017\ \030\024\r\026\027\017\036 )]TJ 0.082 Tw T* (\020\030\026\027\031\035\016\006\017\024\027\027\024\005 \021\022\026\027\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\020\026\033\021 \002\t\f\021\030\036\036 \f\235\024\030\n\ \017)Tj 0 Tw (-)Tj 0.011 Tw T* (\030\024\r\026\021\034 \030\026\027\036\r\024\036 \035\024\032\036 \007\035\ \016 \023\024\f\035\036\007\031\033\013\017\b \023\035\026\f\021\017\004\ \036\f\022\017\b )Tj 0 Tw T* (\024\023\036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\033 \023\030\024\n\036\032\027\024\ \f\021\017)Tj /Span<>> BDC ( )Tj EMC ([27].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 724.8299 Tm [(\020)21(\026\027\r\237\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.06 Tw 10 0 0 10 303.3071 700.4739 Tm (\217\026\027\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\017 \r\ \f\021\030\036\004\026\033\021\f\016 \023\030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (5,4% )Tj 0.133 Tw T* (\f\035\031\004\026\036\r \024\021 \024\002\013\036\005 \002\024\036\r\024\ \005 \021\030\026\r\n\t. \210\f\027\024\r\027\024\005 \023\030\017\004\017\ )Tj 0 Tw (-)Tj -0.024 Tw T* [(\027\024\005 )0.5(\021\026\022\017\b )0.6(\030\026\027\036\027\017\005 )0.5(\r\024 )0.5(\r\030\036\n\016 )0.5(\002\024\036\r\t\b )0.5(\007\036\005\f\021\r\017\005 )0.6(\016\r\035\016\036\021)]TJ 0 Tw (-)Tj -0.042 Tw T* (\f\016 \n\017\027\027\024-\r\030\t\r\027\026\016 \021\030\026\r\n\026. \ \237\021\017 \030\026\027\036\027\017\016, \022\026\022 \023\030\026\r\017\ \035\024, )Tj 0.006 Tw T* (\017\n\036\033\021 \f\024\004\036\021\026\027\027\t\005 \b\026\030\026\022\ \021\036\030 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\020\031\021 \r\022\035\033\004\026\021\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\036\002\016: )Tj 0.036 Tw 0 -1.218 TD [(\024\002\001\017\030\027\t\036 \023\024\r\030\036\032\007\036\027\017\016\ )0.5(\n\016\020\022\017\b \021\022\026\027\036\005 \023\030\024\n\036\032\027\ \024\f\021\017 )]TJ 0.337 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\016\020\024\007\017\004\027\024\005 \024\002\035\026\f\021\017, \024\007\ \027\024\f\021\024\030\024\027\027\017\036 \017\035\017 \007\r\031\f\021\ \024)Tj 0 Tw (-)Tj 0.237 Tw T* (\030\024\027\027\017\036 \024\021\030\t\r\t \027\017\032\027\017\b \022\024\ \027\036\004\027\024\f\021\036\005, \023\024\r\030\036\032\007\036\027\017\ \016 )Tj 0.202 Tw T* (\027\026\030\031\032\027\t\b \023\024\035\024\r\t\b \024\030\020\026\027\ \024\r, \022\024\f\021\036\005 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r )Tj 0.175 Tw T* (\n\026\035\024\020\024 \021\026\026. \202\022\021\031\026\035\034\027\024\ \005 \023\030\024\002\035\036\n\024\005 \016\r\035\016\036\021\f\016 \f\024\ \004\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\026\027\027\026\016 \021\030\026\r\n\026 \r\027\036\002\030\033\001\ \017\027\027\024\005 \004\026\f\021\017 \023\030\016\n\024\005 \022\017\001\ \022\017.)Tj 0.161 Tw 0 -1.218 TD (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \024\f\027\024\r\ \027\t\n \n\036\021\024\007\024\n \035\036\004\036\027\017\016 \002\024)Tj 0 Tw (-)Tj 0.308 Tw 0 -1.218 TD [(\036\r\t\b )0.5(\030\026\027\036\027\017\005 )0.6(\023\030\024\n\036\032\027\024\f\021\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\r\030\036\032\007\036\027\017\036\n )0.6(\r\027\036)]TJ 0 Tw (-)Tj 0.071 Tw 0 -1.218 TD (\002\030\033\001\017\027\027\024\005 \004\026\f\021\017 \023\030\016\n\024\ \005 \022\017\001\022\017 \016\r\035\016\036\021\f\016 \n\036\021\024\007\ 4D: )Tj 0.478 Tw 0 -1.218 TD [(\235\024\030\n\017\030\024\r\026\027\017\036 )0.6(\023\030\024\022\f\017\n\026\035\034\027\024\005 )0.5(\f\021\024\n\t, )0.6(\031\f\021\030\026\027\036\027\017\036 )]TJ 0.232 Tw 0 -1.218 TD (\007\036\235\036\022\021\026 \023\030\016\n\024\005 \022\017\001\022\017\ , \023\030\036\f\026\022\030\026\035\034\027\024\036 \007\030\036\027\017\ \030\024\r\026)Tj 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD (\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\036 \023\030\024\n\t\r\026\027\017\036\ \023\030\016\n\024\005 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.191 Tw 0 -1.218 TD (\023\036\030\r\017\004\027\026\016 \b\017\030\031\030\020\017\004\036\f\022\ \026\016 \024\002\030\026\002\024\021\022\026 \030\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.131 Tw T* [(\007\031\033\013\017\n\017 )0.6(\f\026\027\026\006\017\016\n\017. )0.5(\237\021\024\021 )0.6(\n\036\021\024\007 )0.5(\f\235\024\030\n\017\030\024\r\026\035\f\016 )0.5(\r\024 )]TJ 0.051 Tw 0 -1.218 TD (\r\030\036\n\016 \r\024\005\027\t \r\024 \200\034\036\021\027\026\n\036 \ \017)Tj /Span<>> BDC ( )Tj EMC (\007\024 \f\017\b \023\024\030 \017\f\023\024\035\034\031\036\021\f\016\ )Tj 0.208 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\b \030\026\027\036\027\017\016\b \023\030\024\ \n\036\032\027\024\f\021\017, \023\024\035\031\004\036\027\027\t\b )Tj 0.154 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \002\024\036\r\t\b \022\024\027\235\035\017\022\021\024\r\ . \225)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \023\024\030 \027\036 \021\026\022 \n\027\024\020\024 )Tj 0.169 Tw T* (\f\021\026\021\036\005 \002\t\035\024 \023\024\f\r\016\013\036\027\024 \021\ \026\022\017\n \030\026\027\036\027\017\016\n, \017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036 \024\027\017 )Tj 0.135 Tw T* (\017\n\036\033\021 \024\023\017\f\026\021\036\035\034\027\t\005 \b\026\030\ \026\022\021\036\030, \026)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\027\026\016 \021\026\022\021\017\022\026 )Tj 0.158 Tw T* (\035\036\004\036\027\017\016 \027\036 \017\n\036\036\021 \f\031\013\036\f\ \021\r\036\027\027\t\b \024\021\035\017\004\017\005 \024\021 \n\036\021\024\ \007\026 )Tj 0 Tw T* (4D.)Tj 0.369 Tw T* (\212\026\027\027\t\036 \035\017\021\036\030\026\021\031\030\t, \023\024\f\ \r\016\013\201\027\027\t\036 \035\036\004\036\027\017\033 \021\030\026\r\ \n )Tj 0.112 Tw T* (\023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\005 \004\026\f\021\017 \023\030\ \016\n\024\005 \022\017\001\022\017 )Tj -0.008 Tw T* (\023\024\035\031\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016, \022\026\022 \023\030\026\r\017\ \035\024, \030\026\f\b\024\007\016\021\f\016 )Tj 0.029 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\005 \021\026\022\021\017\022\ \024\005, \023\030\017\027\016\021\024\005 \007\035\016 \035\036\004\036\ \027\017\016 \002\024)Tj 0 Tw (-)Tj -0.002 Tw T* (\036\r\t\b \030\026\027\036\027\017\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \021\030\026\r\n\026\b \026\r\021\024\030\t \f\022\035\ \024\027\016\033\021\f\016 )Tj 0.133 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\ \027\027\024\n\031 \023\024\007\b\024\007\031 \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033, )Tj -0.04 Tw T* (\022\024\021\024\030\024\036 \024\002\t\004\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\005 \017\035\017 \017\027\024\005 \f\021\036\023\036\027\017 \024\ \021\035\017\004\026\036\021\f\016 \024\021 )Tj -0.021 Tw T* (\022\024\027\006\036\023\006\017\017 4D. \224\026\022\032\036 \b\024\030\ \024\001\017\036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\032\007\026\027)Tj 0 Tw (-)Tj 0.168 Tw T* [(\f\022\024\005 \023\030\026\022\021\017\022\036 \023\024\022\026\026\035\ \024 \017\f\023\024\035\034\024\r\026\027\017\036 V)37(A)16(C-\f\017\f\021\036\n, )]TJ 0.248 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\017\f\023\024\035\034\024\r\026\027\017\016 \022\024\021\024\030\t\b )0.5(\023\024\f\035\036 \002\024\036)]TJ 0 Tw (-)Tj T* (\r\t\b \030\026\027\036\027\017\005 \023\030\024\n\036\032\027\024\f\021\ \017 \023\024\007\030\024\002\027\024 \027\036 \024\023\017\f\026\027\026\ .)Tj 0.009 Tw T* (\225\021\024\017\021 \024\021\n\036\021\017\021\034, \004\021\024 \n\036\ \021\024\007\t \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t \035\036\004\036\027\017\016 \030\026\ \027 )Tj 0.254 Tw T* (\023\030\024\n\036\032\027\024\f\021\017, \023\024\035\031\004\036\027\027\ \t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016, \027\036\035\034\016 )Tj 0.297 Tw T* [(\024\007\027\024\027\026\004\027\024 )0.6(\023\030\024\036\006\017\030\024\r\026\021\034 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.205 0 Td [(\021\026\022\021\017\022\031 )0.5(\035\036\004\036\027\017\016 )0.6(\002\024)]TJ 0 Tw (-)Tj 0.322 Tw -13.205 -1.218 Td (\036\r\t\b \023\024\r\030\036\032\007\036\027\017\005 \023\030\024\n\036\ \032\027\024\f\021\017. \210\002\001\017\030\027\t\036 \030\026\027\t )Tj 0.289 Tw 0 -1.218 TD (\023\030\024\n\036\032\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016 \027\026\027\024\f\016\021\f\016\ \026\020\036\027\021\026\n\017 )Tj 0.219 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \023\036\030\036\007\026\004\036\005 \022\017\027\036\ \021\017\004\036\f\022\024\005 \220\027\036\030\020\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\017 )Tj 0.148 Tw 0 -1.218 TD (\023\024\r\030\036\032\007\036\027\017\016 \027\036 \027\026\f\021\024\035\ \034\022\024 \n\026\f\f\017\r\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\026\020\030\016\027\036\027\t, )Tj -0.009 Tw T* (\004\021\024 \f\031\013\036\f\021\r\036\027\027\024 \024\021\035\017\004\ \026\036\021 \017\b \024\021 \030\026\027\036\027\017\005, \023\024\035\031\ \004\036\027\027\t\b )Tj 0.204 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\036\027\027\024\036 \r\030\036\n\016. \207\024\036\r\t\036 \030\026\ \027\036\027\017\016 \024\002\035\026\007\026\033\021 \024\023\030\036)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD (\007\036\035\201\027\027\t\n\017 \024\f\024\002\036\027\027\024\f\021\016\ \n\017, \022\024\021\024\030\t\036 \024\021\035\017\004\026\033\021 \017\ \b \024\021 )Tj 0.104 Tw 0 -1.218 TD (\002\t\021\024\r\t\b \021\030\026\r\n. \237\021\024 \027\026\035\017\004\ \017\036 \021\030\201\b \024\027 \023\024\r\030\036\032\007\036\027\017\ \016: )Tj 0.147 Tw 0 -1.218 TD (\030\026\027\036\r\024\005 \022\026\027\026\035, \024\027\026 \023\036\030\ \r\017\004\027\024\020\024 \027\036\022\030\024\026, \024\027\026 \r\021\ \024)Tj 0 Tw (-)Tj 0.04 Tw 0 -1.218 TD (\030\017\004\027\024\020\024 \027\036\022\030\024\026 $\n\024\035\036\022\ \031\035\016\030\027\024\020\024 \f\024\021\030\016\f\036\027\017\016$;\ \027\026\035\017)Tj 0 Tw (-)Tj -0.068 Tw 0 -1.218 TD (\004\017\036 \024\002\001\017\030\027\024\020\024 \026\020\030\016\027\ \036\027\017\016 \030\026\027\t \036\n\035\201\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\026)Tj 0 Tw (-)Tj 0.085 Tw 0 -1.218 TD (\033\013\017\n\017 \026\020\036\027\021\026\n\017; \027\026\035\017\004\017\ \036 \024\002\001\017\030\027\t\b \027\036\022\030\024\021\017\004\036\f\ \022\017\b )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7653 56.0378 Tm (120)Tj ET endstream endobj 477 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 343.4568 42.7216 Tm [(Sur)31(ger)-30.9(y of militar)-31(y injuries of th)11(e perineum $r)31(e)11(vie)11(w$)]TJ -40.125 0 Td [(\224\b\017\220\017\020\b\213\f\205\007\005 \026)11(\005\007)-10(\026\b\007\005 \013\f\213\f\t\b \223\005\216\b\f\t\026)11.1(\025\016 \205\022\210\025\f\016\240\024\b )]TJ 0 -1 TD [(\017\005\t\f\t\b\024\b \223\017\025\024\f\235\t\025\205)-10(\026\b $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-19.9(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.098 Tw 10 0 0 10 42.5197 724.8299 Tm [(\024\004\036\030\036\007\034 Ar)-16(mstr)-31.9(ong)]TJ /Span<>> BDC ( )Tj EMC (R.G. \024\021\n\036\004\026\035, \004\021\024 \031)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\t\b \f\024\035)Tj 0 Tw (-)Tj 0.09 Tw 0 -1.218 TD (\007\026\021, \r\f\035\036\007\f\021\r\017\036 \024\002\036\r\024\032\017\ \r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 \n\024)Tj 0 Tw (-)Tj 0.011 Tw T* (\020\031\021 \024\002\030\026\024\r\t\r\026\021\034\f\016 \023\035\024\021\ \027\t\036 \022\026\035\024\r\t\036 \n\026\f\f\t, \022\024\021\024\030\t\ \036 )Tj 0.054 Tw T* [(\006\036\035\036\f\024\024\002\030\026\027\024 )0.6(\031\007\026\035\016\021\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.729 0 Td [(\023\024\n\024\013\034\033 )0.5(\007\017\f\021\026\035\034\027\024\020\024 )0.6(\023\030\024)]TJ 0 Tw (-)Tj 0.075 Tw -10.729 -1.218 Td (\n\t\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC [([21]. \215\030\024\r\036\007\036\027\017\036 )0.5(\007\017\f\021\026\035\034\027\024\020\024 \023\030\024\n\t\r\026\027\017\ \016 )]TJ 0.154 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\027\t\b \r\027\036\002\030\033\001\017\027\027\ \t\b \023\024\r\030\036\032\007\036\027\017\016\b \023\030\016)Tj 0 Tw (-)Tj 0.12 Tw 0 -1.218 TD (\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016 \030\016\007\024\n \026\r\021\024\ \030\024\r \f\021\026\r\017\021\f\016 )Tj -0.045 Tw 0 -1.218 TD [(\023\024\007 \f\024\n\027\036\027\017\036. Br)-32(o)-13.9(wn)]TJ /Span<>> BDC ( )Tj EMC [(Car)-30(l)30.1(os V.R., \022)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\030\031, \f\024\024\002\013\026\036\021, )Tj -0.011 Tw T* (\004\021\024 \007\017\f\021\026\035\034\027\024\036 \023\030\024\n\t\r\026\ \027\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036)Tj 0 Tw (-)Tj 0.095 Tw T* (\027\017\016\n\017 \023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\032\007\026\027\f\022\017\b )Tj -0.008 Tw T* [(\031\f\035\024\r\017\016\b )0.6(\031\r\036\035\017\004\017\r\026\036\021 )0.5(\030\017\f\022 )0.5(\017\027\235\036\022\006\017\024\027\027\t\b )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 18.705 0 Td (\026\002\007\024\n\017)Tj 0 Tw (-)Tj -18.705 -1.218 Td (\027\026\035\034\027\t\b \024\f\035\024\032\027\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC ([8].)Tj 0.004 Tc 0.102 Tw 0 -1.218 TD (\225\026\027\026\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\036 \023\030\036\f\026\022\030\ \026\035\034\027\024\020\024 \023\030\024\f\021\030\026\027)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.001 Tw 0 -1.218 TD (\f\021\r\026, \022\026\022 \023\030\026\r\017\035\024, \023\030\024\r\024\ \007\017\021\f\016 \023\024\f\030\036\007\f\021\r\024\n \023\024\023\036\ \030\036\004)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc -0.036 Tw 0 -1.218 TD (\027\024\020\024 \030\026\030\036\026 \023\030\024\n\036\032\027\024\f\ \021\017 \n\036\032\007\031 \026\027\031\f\024\n \017)Tj /Span<>> BDC ( )Tj EMC [(\022\024\023\004\017\022\024\n)4( )]TJ 0.177 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \021\031\023\t\n \030\026\007\036\ \035\036\027\017\036\n \021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.211 Tw T* [(\027\024\r\022\024\005 )0.5(\007\030\036\027\026\032\026. \215\030\036\f\026\022\030\026\035\034\027\ \t\005 )0.5(\007\030\036\027\026\032 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.273 0 Td (\002\024\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.263 Tw -20.273 -1.218 Td (\r\t\b \021\030\026\r\n\026\b \024\002\036\f\023\036\004\017\r\026\036\021\ \026\007\036\022\r\026\021\027\024\036 \007\030\036\027\017\030\024\r\026\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.139 Tw T* [(\027\017\036 \030\026\027\t, \f\027\017\032\026\016 \030\017\f\022 \017\027\ \235\036\022\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005\ )4( )]TJ 0.286 Tw T* ([1,6,21]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\021\n\036\004\026\036\021\f\016 \r\036\030\024\016\021\ \027\024\f\021\034 \030\026\r\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.305 Tw T* [(\021\017\016 )0.5(\022\030\024\r\024\021\036\004\036\027\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.3 0 Td [(\b\024\007\036 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\007\024\f\021\031\023\026)4( )]TJ 0.347 Tw -9.3 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\f\026\022\030\026\035\034\027\024\n\031 \023\030\024\f\021\030\ \026\027\f\021\r\031 [21]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n)4( )]TJ 0.272 Tw T* (\027\036\022\024\021\024\030\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ , \023\030\036\f\026\022\030\026\035\034\027\024\036 \007\030\036\027\017\ \030\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.345 Tw T* (\r\026\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\016\b \023\030\024\n\036\032\027\024\ \f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\n\017\030\027\024\036)4( )]TJ 0.169 Tw T* [(\r\030\036\n\016 )0.5(\027\036 )0.5(\031\n\036\027\034\001\026\036\021 )0.5(\030\017\f\022 )0.5(\017\027\235\036\022\006\017\024\027\027\t\b )0.5(\024\f\035\024\032\027\036)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.136 Tw T* (\027\017\005, \002\024\035\036\036 \021\024\020\024 \n\024\032\036\021 \023\ \030\017\r\036\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\016\021\030\024\020\036\027\027\024\n\031 \017\027)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.171 Tw T* [(\235\017\006\017\030\024\r\026\027\017\033 )0.5(\023\030\036\f\026\022\030\026\035\034\027\024\020\024 )0.5(\023\030\024\f\021\030\026\027\f\021\r\026)]TJ /Span<>> BDC ( )Tj EMC 19.365 0 Td [([8,10].)4( )]TJ 0.172 Tw -19.365 -1.218 Td [(Br)-32(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(Car)-30(l)30(os)]TJ /Span<>> BDC ( )Tj EMC (V.R. \023\017\001\036\021, \004\021\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \023\024\r\030\036\032)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.135 Tw T* [(\007\036\027\017\016 \023\030\016\n\024\005 \022\017\001\022\017, \023\030\ \036\f\026\022\030\026\035\034\027\024\036 \007\030\036\027\017\030\024\r\ \026\027\017\036)4( )]TJ -0.037 Tw T* [(\n\024\032\036\021 )0.5(\023\030\017\r\036\f\021\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 7.488 0 Td [(\030\026\035\017\004\027\t\n )0.5(\026\002\007\024\n\017\027\026\035\034\027\t\n )0.5(\024\f\035\024\032)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc -7.488 -1.218 Td (\027\036\027\017\016\n [8].)Tj 0 Tc 0.17 Tw T* (\200 \035\017\021\036\030\026\021\031\030\036 \024\023\017\f\t\r\026\036\ \021\f\016 \023\030\036\017\n\031\013\036\f\021\r\024 \017\f\023\024\035\ \034\024)Tj 0 Tw (-)Tj 0.128 Tw T* (\r\026\027\017\016 \220\027\021\036\030\026\035\034\027\024\020\024 \023\ \017\021\026\027\017\016 \023\036\030\036\007 \023\026\030\036\027\021\036\ \030\026\035\034\027\t\n )Tj 0.281 Tw T* (\023\017\021\026\027\017\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\016\n\017 \023\030\024\n\036\032\027\ \024)Tj 0 Tw (-)Tj 0.296 Tw T* (\f\021\017)Tj /Span<>> BDC ( )Tj EMC ([2,19]. \200\024\027\017\022\027\024\r\036\027\017\036 \030\026\035\017\ \004\027\t\b \f\036\023\021\017\004\036\f\022\017\b )Tj 0.576 Tw T* (\024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\036\027\021\036\030\026\035\034\027\024\n \023\017\021\026\027\ \017\017 \002\t\035\024 )Tj 0.362 Tw T* (\f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\t\n \017\f\023\024\035\034\024\r\026\027\ \017\036\n \r\036\027\024\027\024\020\024 )Tj 0.037 Tw T* [(\022\026\021\036\021\036\030\026. M)-24(ossadegh)]TJ /Span<>> BDC ( )Tj EMC (\200.S. \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\201\n \017\f\f\035\036\007\024\r\026\027\017\017 \023\030\024)Tj 0 Tw (-)Tj 0.334 Tw T* (\r\201\035 \024\006\036\027\022\031 \220\235\235\036\022\021\017\r\027\024\ \f\021\017 \220\027\021\036\030\026\035\034\027\024\020\024 \023\017\021\ \026\027\017\016, )Tj 0.133 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n 55% $46 \017)Tj /Span<>> BDC ( )Tj EMC (83$ \023\026\006\017\036\027\021\024\r \023\024\035\031\004\026\035\017\ \220\027\021\036)Tj 0 Tw (-)Tj T* (\030\026\035\034\027\024\036 \023\017\021\026\027\017\036, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b 89% $41 \017)Tj /Span<>> BDC ( )Tj EMC (46$ \r\t\032\017\035\017. )Tj 0.081 Tw T* (\214\036\021\026\035\034\027\024\f\021\034 \002\t\035\026 \027\017\032\036\ \031)Tj /Span<>> BDC ( )Tj EMC (\021\036\b, \022\021\024 \023\024\035\031\004\026\035 \220\027\021\036\030\ \026\035\034)Tj 0 Tw (-)Tj T* (\027\024\036 \023\017\021\026\027\017\036 [2].)Tj 0.105 Tw T* (\224\026\022\032\036 \030\026\035\017\004\027\t\n\017 \026\r\021\024\030\ \026\n\017 \024\023\017\f\t\r\026\035\017\f\034 \r\026\030\017\026\027\021\ \t )Tj 0.473 Tw T* [(\f\024\004\036\021\026\027\017\016 )0.6(\024\f\027\024\r\027\t\b )0.5(\026\f\023\036\022\021\024\r )0.5(\004\036\021\t\030\201\b\022\024\n\023\024\027\036\027\021)]TJ 0 Tw (-)Tj 0.061 Tw T* (\027\024\005 \f\017\f\021\036\n\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\032\007\026\027\f\022\017\b \021\030\026\r\n\026\b \023\030\ \024\n\036\032\027\024\f\021\017 )Tj 0.136 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \r\027\036\002\030\033\001\017\ \027\027\024\005 \004\026\f\021\017 \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.175 Tw T* [(\022\017. K)25(enne)-12(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC (A. \024\023\017\f\t\r\026\036\021 \031\f\023\036\001\027\024\036 \017\f\023\ \024\035\034\024\r\026\027\017\036 )Tj 0.116 Tw T* (\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\020\024 \023\030\024\n\t\r\026\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\026)Tj 0 Tw (-)Tj 0.377 Tw T* (\027\026\006\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\036\n \030\026\027 \023\030\024\ \n\036\032\027\024\f\021\017 [19]. )Tj 0.47 Tw T* [(Br)-24(ent)]TJ /Span<>> BDC ( )Tj EMC (Emigh \030\036\022\024\n\036\027\007\031\036\021 \023\030\024\r\024\007\017\ \021\034 \021\030\026\027\f\026\027\026\035\034)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\024\036 \031\001\017\r\026\027\017\036 \023\030\016\n\024\005 \022\017\ \001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \027\036\r\024\n\024\032\027\024\f\021\017 )Tj 0.181 Tw T* (\031\001\017\r\026\027\017\016 \235\024\030\n\017\030\024\r\026\021\034 \ \023\030\024\022\f\017\n\026\035\034\027\031\033 \f\021\024\n\031 [16]. \ )Tj 0.145 Tw T* [(Har)-10(shi)-23.9(t)]TJ /Span<>> BDC ( )Tj EMC [(A)-25(gar)-38(w)-12(al \024\023\017\f\t\r\026\036\021 \024\023\t\021 \035\036\004\036\027\017\ \016 \024\002\001\017\030\027\t\b )]TJ 0.324 Tw 23.244 64.543 Td (\030\026\027 \023\030\024\n\036\032\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \f\024\004\036\021\026\027\027\t\n\017\ \023\024)Tj 0 Tw (-)Tj 0.239 Tw T* (\r\030\036\032\007\036\027\017\016\n\017, \022\024\021\024\030\t\005 \r\022\ \035\033\004\026\035 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj 0.162 Tw T* (\f\022\031\033 \024\002\030\026\002\024\021\022\031 \030\026\027, \235\024\ \030\n\017\030\024\r\026\027\017\036 \023\030\024\022\f\017\n\026\035\034\ \027\024\005 )Tj 0.07 Tw T* (\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC [(\031\f\021\026\027\024\r\022\031 )0.5(\031\030\036\021\030\026\035\034\027\024\020\024 )0.5(\022\026\021\036\021\036\030\026 \035\017\002\024 )0.5(\235\024\030)]TJ 0 Tw (-)Tj T* (\n\017\030\024\r\026\027\017\036 \006\017\f\021\024\f\021\024\n\t)Tj /Span<>> BDC ( )Tj EMC ([6].)Tj 0.137 Tw T* (\230\n\036\036\021\f\016 \027\036\002\024\035\034\001\024\036 \022\024\035\ \017\004\036\f\021\r\024 \017\f\021\024\004\027\017\022\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024)Tj 0 Tw (-)Tj 0.033 Tw 0 -1.218 TD [(\030\t\b \020\024\r\024\030\017\021\f\016 \024\002 \017\f\023\024\035\034\ \024\r\026\027\017\017 V)37(A)16(C-\f\017\f\021\036\n \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 0.452 Tw 0 -1.218 TD [(\001\017\030\027\t\b )0.5(\002\024\036\r\t\b )0.6(\030\026\027\036\027\017\016\b )0.5(\023\030\024\n\036\032\027\024\f\021\017, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 19.782 0 Td (\f\r\016\017 )Tj 0.044 Tw -19.782 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC 0.714 0 Td [(\004\036\n, )0.5(\024\f\021\026\201\021\f\016 )0.6(\027\036\016\f\027\024\005 )0.5(\017\b )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 19.131 0 Td (\021\026\022\017\b )Tj 0.027 Tw -19.844 -1.218 Td (\030\026\027\036\027\017\016\b [22,25]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \030\016\007 \017\f\f\035\036\ \007\024\r\026\027\017\005 )Tj 0.306 Tw T* [(\023\024\f\r\016\013\036\027 \017\f\023\024\035\034\024\r\026\027\017\033\ V)37(A)16(C-\f\017\f\021\036\n \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017)Tj 0 Tw (-)Tj 0.12 Tw T* (\016\b \023\030\024\n\036\032\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \024\002\001\017\030)Tj 0 Tw (-)Tj 0.065 Tw 0 -1.218 TD (\027\t\b \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \ \030\026\027 \023\030\024\n\036\032\027\024\f\021\017 [6,11,26]. )Tj 0.009 Tw 0 -1.218 TD (\200\024)Tj /Span<>> BDC ( )Tj EMC [(\r\f\036\b \220\021\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\017\b )0.5(\023\024\r\030\036\032\007\036\027\017\016\b )]TJ -0.013 Tw 0 -1.218 TD [(\024\021\n\036\004\026\036\021\f\016 \r\t\f\024\022\026\016 \220\235\235\ \036\022\021\017\r\027\024\f\021\034 )0.5(\023\030\017\n\036\027\036\027\017\016 )0.5(V)36.9(A)16(C-)]TJ 0.068 Tw T* (\f\017\f\021\036\n. \212\024\f\021\024\r\036\030\027\024 \031\n\036\027\034\ \001\026\033\021\f\016 \f\030\024\022\017 \026\032\017\r\035\036\027\017\ \016 )Tj 0.118 Tw T* (\030\026\027, \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\026\036\021\f\016 \022\024\035\017\004\036\f\021\r\024 \017\ \027\235\036\022\006\017\024\027\027\t\b \024\f\035\024\032)Tj 0 Tw (-)Tj 0.181 Tw T* (\027\036\027\017\005. \025)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\030\031, L)-32(abler)]TJ /Span<>> BDC ( )Tj EMC (L. \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\201\n \017\f\f\035\036\007\024\r\026\027\017\017, )Tj 0.289 Tw T* (\023\024\f\r\016\013\201\027\027\024\n \027\036\002\024\036\r\024\005 \021\ \030\026\r\n\036 \023\030\024\n\036\032\027\024\f\021\017, \024\023\017)Tj 0 Tw (-)Tj 0.132 Tw T* [(\f\t\r\026\036\021 \017\f\023\024\035\034\024\r\026\027\017\036 V)37(A)16(C-\023\024\r\016\024\022 \031)]TJ /Span<>> BDC ( )Tj EMC (13)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r. )Tj -0.015 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\f\030\036\007\027\036\n )0.5(\021\036\030\026\023\017\016 \f)]TJ /Span<>> BDC ( )Tj EMC 8.606 0 Td [(\017\b \017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\023\030\024\r\024\007\017\035\026\f\034 )]TJ 0.228 Tw -8.606 -1.218 Td [(15 )0.6(\007\027\036\005, )0.5(V)37(A)16(C-\023\024\r\016\022\017 )0.7(\n\036\027\016\035\017 )0.6(\024\007\017\027 )0.6(\030\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 18.476 0 Td [(\021\030\017 )0.6(\007\027\016. )]TJ 0.431 Tw -18.476 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\026\022\021\036\030\017\024\035\024\020\017\004\036\f\022\024\n \017\ \f\f\035\036\007\024\r\026\027\017\017 \002\t\035\024 \024\002)Tj 0 Tw (-)Tj 0.285 Tw T* (\027\026\030\031\032\036\027\024 \027\026\004\017\021\036\035\034\027\024\ \036 \f\027\017\032\036\027\017\036 \024\002\f\036\n\036\027\201\027\027\ \024\f\021\017 )Tj 0.057 Tw T* [(\030\026\027\t, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.33 0 Td [(\f\030\036\007\027\036\n, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.188 0 Td [(13-\036 )0.5(\f\031\021\022\017 )0.6(V)37(A)16(C-\021\036\030\026\023\017\017, )0.6(\022\024\021\024\030\024\036 )]TJ 0.385 Tw -8.518 -1.218 Td (\022\024\030\030\036\035\017\030\024\r\026\035\024 \f\024 \f\027\017\032\ \036\027\017\036\n \031\030\024\r\027\016 \035\036\005\022\024\006\017\021\ \024\r )Tj -0.018 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(C-\030\036\026\022\021\017\r\027\024\020\024 \002\036\035\022\026. \215\024\ \f\035\036 V)36.9(A)16.1(C-\021\036\030\026\023\017\017 \031)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 )Tj 0.167 Tw T* [(\004\026\f\021\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\030\026\027\t )0.5(\002\t\035\017 )0.6(\031\001\017\021\t, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 16.471 0 Td [(\031 )0.5(\024\f\021\026\r\001\017\b\f\016 )]TJ 0.123 Tw -16.471 -1.218 Td (\002\t\035\017 \r\t\023\024\035\027\036\027\t \023\035\026\f\021\017\004\ \036\f\022\017\036 \r\n\036\001\026\021\036\035\034\f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.111 Tw T* (\n\024\013\034\033 \f\036\021\004\026\021\024\020\024 \021\030\026\027\f\ \023\035\026\027\021\026\021\026 \017\035\017 \f\r\024\002\024\007\027\024\ \020\024 \035\024)Tj 0 Tw (-)Tj 0.256 Tw T* [(\f\022\031\021\026 [26]. Must)15(af)16(a)]TJ /Span<>> BDC ( )Tj EMC (T.O. \024\023\017\f\t\r\026\036\021 \220\235\235\036\022\021\017\r\027\024\ \f\021\034 )Tj 0.137 Tw T* [(V)37(A)16(C-\f\017\f\021\036\n \031)]TJ /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\024\023\026\r\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\212\224\215 \017\035\017 \023\024)Tj 0 Tw (-)Tj 0.395 Tw T* [(\035\031\004\017\r\001\017\b )0.6(\n\017\027\027\024-\r\030\t\r\027\024\036 )0.6(\030\026\027\036\027\017\036 )0.5(\023\030\024\n\036\032\027\024\f\021\017. )]TJ 0.272 Tw T* [(\225\n\036\027\026 V)37(A)16(C-\023\024\r\016\022\017 \023\030\024\017\f\b\024\007\017\035\026 1)]TJ /Span<>> BDC ( )Tj EMC (\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\026 \007\027\016. )Tj 0.122 Tw T* (\200\024)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \021\036\030\026\023\017\017 \017\f\023\024\035\034\024\ \r\026\035\024\f\034 \007\026\r\035\036\027\017\036 125)Tj /Span<>> BDC ( )Tj EMC (\n\n )Tj 0.179 Tw T* (\030\021. \f\021. \200)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(17-\036 \f\031\021\022\017 \023\024\f\035\036 \027\026\004\026\035\024 V\ )36.9(A)16.1(C-)]TJ 0.195 Tw T* (\021\036\030\026\023\017\017 \024\021\n\036\004\026\035\024\f\034 \027\026\ \004\017\021\036\035\034\027\024\036 \f\027\017\032\036\027\017\036 \002\ \026\022\021\036)Tj 0 Tw (-)Tj 0.34 Tw T* [(\030\017\026\035\034\027\024\005 \024\002\f\036\n\036\027\201\027\027\024\ \f\021\017. )0.5(\202\r\021\024\030\t \024\021\n\036\004\026\035\017 \036\032\036)]TJ 0 Tw (-)Tj 0.146 Tw T* (\027\036\007\036\035\034\027\024\036 \031\n\036\027\034\001\036\027\017\036\ \030\026\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (0,5\2261)Tj /Span<>> BDC ( )Tj EMC (\f\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\031 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj /Span<>> BDC ( )Tj EMC (5\22610% \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\036 [22].)Tj 0.615 Tw T* [(\237\235\235\036\022\021\017\r\027\024\f\021\034 \017\f\023\024\035\034\ \024\r\026\027\017\016 V)37(A)16(C-\023\024\r\016\024\022 \024\002\031)]TJ 0 Tw (-)Tj -0.003 Tw T* (\f\035\024\r\035\036\027\026 \022\026\004\036\f\021\r\036\027\027\t\n \031\ \007\026\035\036\027\017\036\n \030\026\027\036\r\024\020\024 \f\036\022\ \030\036\021\026, )Tj 0.295 Tw T* (\031\f\021\030\026\027\036\027\017\036\n \024\021\036\022\026 \021\022\026\ \027\036\005, \031\035\031\004\001\036\027\017\036\n \n\017\022\030\024\006\ \017\030)Tj 0 Tw (-)Tj 0.389 Tw T* (\022\031\035\016\006\017\017, \f\027\017\032\036\027\017\036\n \002\026\022\ \021\036\030\017\026\035\034\027\024\005 \024\002\f\036\n\036\027\201\027\ \027\024)Tj 0 Tw (-)Tj 0.157 Tw T* (\f\021\017 \021\022\026\027\036\005, \004\021\024 \f\023\024\f\024\002\f\ \021\r\031\036\021 \002\024\035\036\036 \002\t\f\021\030\024\n\031 \030\024\ \f\021\031 )Tj 0.123 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.874 0 Td [(\f\024\030\036\r\026\027\017\033 )0.6(\020\030\026\027\031\035\016\006\017\024\027\027\024\005 )0.5(\021\022\026\027\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 16.051 0 Td (\026\032\017\r\035\036\027\017\033 )Tj 0.245 Tw -16.924 -1.218 Td [(\030\026\027\t. )0.5(\025\024\035\017\004\036\f\021\r\024 )0.6(\f\036\026\027\f\024\r )0.5(V)37(A)16(C-\021\036\030\026\023\017\017 )0.6(\026\r\017\f\017\021 )0.5(\024\021 )]TJ -0.017 Tw T* (\030\026\n\036\030\026 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\030\024\f\021\017 \036\201 \026\032\017\r\035\036\027\017\016\ . \200)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017\f)Tj 0 Tw (-)Tj 0.105 Tw T* [(\f\035\036\007\024\r\026\027\017\017 \024\021\n\036\004\026\035\026\f\034\ \r\t\f\024\022\026\016 \220\235\235\036\022\021\017\r\027\024\f\021\034\ V)37(A)16(C )]TJ 0.159 Tw T* (\023\024\r\016\024\022, \022\026\022 \023\024\007\020\024\021\024\r\017\ \021\036\035\034\027\024\020\024 \220\021\026\023\026 \007\035\016 \023\024\ \f\035\036\007\031)Tj 0 Tw (-)Tj 0.18 Tw T* (\033\013\017\b \023\035\026\f\021\017\004\036\f\022\017\b \024\023\036\030\ \026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \024\002\001\017\030\027\t\b )Tj 0.332 Tw T* [(\030\026\027 \023\030\024\n\036\032\027\024\f\021\017. \230\f\023\024\035\ \034\024\r\026\027\017\036 V)37(A)16(C \f\017\f\021\036\n \023\024)]TJ 0 Tw (-)Tj 0.1 Tw T* [(\r\024\035\016\035\024 )0.6(\022\026\004\036\f\021\r\036\027\027\024 )0.5(\023\024\007\020\024\021\024\r\017\021\034 )0.6(\030\026\027\036\r\024\036 )0.5(\035\024\032\036 )0.6(\007\035\016 )]TJ 0.362 Tw T* (\007\026\035\034\027\036\005\001\036\005 \023\035\026\f\021\017\022\017,\ \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \031\n\036\027\034\001\036\027\017\016 \024\021\201\022\026\ , )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_2 1 Tf 25 0 0 25 504.6646 56.0378 Tm (119)Tj ET endstream endobj 476 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.156 Tw 10 0 0 10 70.8661 724.8299 Tm (\n\036\030\024\023\030\017\016\021\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\022\026\026\027\017\036\n \023\036\030\r\024\005 \n\036\007\017\006\ \017\027\f\022\024\005 \023\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\n\024\013\017 \023\024\f\021\030\026\007\026\r\001\017\n.)Tj -0.006 Tw T* (\212\026\027\027\024\005 \021\026\022\021\017\022\017 \035\036\004\036\027\ \017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\b \002\024\036\r\t\b \030\026\027\036)Tj 0 Tw (-)Tj 0.155 Tw T* (\027\017\016\b \023\030\024\n\036\032\027\024\f\021\017 \023\030\017\007\ \036\030\032\017\r\026\035\017\f\034 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\024\f\035\036\007\031)Tj 0 Tw (-)Tj 0.138 Tw T* (\033\013\017\b \022\030\031\023\027\t\b \r\024\036\027\027\t\b \022\024\027\ \235\035\017\022\021\026\b. \207\024\035\034\001\026\016 \004\026\f\021\034\ )Tj 0.08 Tw T* (\f\021\026\021\036\005, \023\024\f\r\016\013\201\027\027\t\b \007\026\027\ \027\024\n\031 \021\017\023\031 \030\026\027\036\027\017\005, \027\024\f\ \017\035\026, )Tj 0.154 Tw 0 -1.218 TD (\023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \024\023\017\f\026\ \021\036\035\034\027\t\005 \b\026\030\026\022\021\036\030 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\t)Tj 0 Tw (-)Tj 0.087 Tw 0 -1.218 TD (\r\026\036\n\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \021\026\022\021\017\022\026 \035\036\004\036\027\017\016 \f\031\ \013\036\f\021\r\036\027\027\024 \027\036 \024\021\035\017)Tj 0 Tw (-)Tj T* (\004\026\035\026\f\034 \024\021 \023\030\017\027\006\017\023\026 4D.)Tj 0.141 Tw T* (\200 \002\024\035\034\001\017\027\f\021\r\036 \f\021\026\021\036\005, \023\ \024\f\r\016\013\201\027\027\t\b \035\036\004\036\027\017\033 \030\026\027\ \036)Tj 0 Tw (-)Tj 0.241 Tw T* (\027\017\005 \023\030\024\n\036\032\027\024\f\021\017, \002\024\035\034\001\ \031\033 \030\024\035\034 \024\021\r\024\007\016\021 \021\013\026\021\036\ \035\034)Tj 0 Tw (-)Tj 0.143 Tw T* [(\027\024\005 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.5(\024\002\030\026\002\024\021\022\036 )0.6(\030\026\027\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.453 0 Td (\023\024\f\035\036\007\031\033\013\036\005 )Tj 0.256 Tw -16.453 -1.218 Td (\036\032\036\007\027\036\r\027\024\005 \f\026\027\026\006\017\036\005 \026\ \027\021\017\f\036\023\021\017\004\036\f\022\017\n\017 \030\026\f\021\r\024\ \030\026)Tj 0 Tw (-)Tj -0.004 Tw 0 -1.218 TD (\n\017)Tj /Span<>> BDC ( )Tj EMC ([1,2,19,20]. \025)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\030\031, Jegana)15(t)-12.9(han)]TJ /Span<>> BDC ( )Tj EMC (A.N. \024\023\017\f\t\r\026\036\021 )Tj -0.031 Tw 0 -1.218 TD (\023\036\030\r\017\004\027\031\033 \b\017\030\031\030\020\017\004\036\f\022\ \031\033 \024\002\030\026\002\024\021\022\031 \030\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036)Tj 0 Tw (-)Tj 0.025 Tw T* [(\027\017\017 \253\022\026\022 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\035\017\021\024\021\024\n\017\017\273, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\031\033\013\017\n\017 )0.5(\036\032\036\007\027\036\r)]TJ 0 Tw (-)Tj 0.135 Tw T* [(\027\t\n\017 \024\002\030\026\002\024\021\022\026\n\017 )0.5(\030\026\027\t \r)]TJ /Span<>> BDC ( )Tj EMC 11.622 0 Td [(\024\023\036\030\026\006\017\024\027\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0 Tw -11.622 -1.218 Td (\n\017\027\017\n\031\n \021\030\201\b \007\027\036\005 [20].)Tj 0.231 Tw T* [(\200 )0.5(\002\024\035\034\001\017\027\f\021\r\036 )0.6(\f\021\026\021\036\005, )0.5(\023\024\f\r\016\013\201\027\027\t\b )0.5(\002\024\036\r\t\n )0.5(\030\026\027\036)]TJ 0 Tw (-)Tj 0.177 Tw T* (\027\017\016\n \023\030\024\n\036\032\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \023\030\016\n\024\005 \022\ \017\001\022\017, )Tj 0.126 Tw T* [(\026\r\021\024\030\t \030\036\022\024\n\036\027\007\031\033\021 )0.5(\017\035\017 \024\023\017\f\t\r\026\033\021 \235\024\030\n\017\030\024\r\ \026\027\017\036 )]TJ 0.087 Tw T* [(\023\030\024\022\f\017\n\026\035\034\027\024\005 )0.5(\f\021\024\n\t [1,2,7,21,22,23]. Ma)-17(cF)20(ar)-30(l)-15.9(ane)]TJ /Span<>> BDC ( )Tj EMC (C., )Tj 0.166 Tw T* (\024\007\027\026\022\024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\201\n \017\f\f\035\036\007\024\r\026\027\017\017 \r\t\f\022\026\ \026\035 \n\027\036\027\017\036 \024\002 )Tj 0.094 Tw T* [(\024\021\f\031\021\f\021\r\017\017 \027\036\024\002\b\024\007\017\n\024\f\ \021\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \023\030\024\022\f\017)Tj 0 Tw (-)Tj 0.209 Tw T* [(\n\026\035\034\027\024\005 )0.5(\f\021\024\n\t \023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\027\036\027\017\016\b )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, \022\024\021\024)]TJ 0 Tw (-)Tj 0.058 Tw T* (\030\t\036 \002\t\035\017 \031\f\021\030\026\027\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\036 \f\030\024\022\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 )Tj 0.307 Tw T* (\027\026\004\017\021\036\035\034\027\024\020\024 \026\020\030\016\027\ \036\027\017\016 \030\026\027\t. \203\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b )Tj 0.266 Tw T* (\f\035\031\004\026\016\b \026\r\021\024\030 \027\026\f\021\026\017\r\026\ \036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \023\030\024\022)Tj 0 Tw (-)Tj 0.2 Tw T* [(\f\017\n\026\035\034\027\024\005 \f\021\024\n\t [21]. Gl)-16(asgo)-14(w)]TJ /Span<>> BDC ( )Tj EMC (S.C. \024\023\017\f\t\r\026\036\021 \023\024)Tj 0 Tw (-)Tj 0.156 Tw T* (\r\t\001\036\027\017\036 \031\030\024\r\027\016 \035\036\021\026\035\034\ \027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \f\021\024\n\t )Tj 0.311 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC 6.027 0 Td [(\022\024\035\024\030\036\022\021\026\035\034\027\024\005 )0.5(\021\030\026\r\n\024\005, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.24 Tw -6.027 -1.218 Td (\027\017\033 \f\024 \f\021\024\n\017\030\024\r\026\027\027\t\n\017 \030\026\ \027\036\027\t\n\017 $10,8%, \023\030\024\021\017\r )Tj 0.111 Tw T* (3,7%$)Tj /Span<>> BDC ( )Tj EMC [([23]. Must)15(af)16(a)]TJ /Span<>> BDC ( )Tj EMC (T.O. \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\201\n \017\f\f\035\036\007\024\r\026\027\017\017 \024\023\017)Tj 0 Tw (-)Tj 0.129 Tw T* (\f\t\r\026\036\021, \004\021\024 \r\f\036\n \023\024\f\021\030\026\007\026\ \r\001\017\n \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\n\017 \030\026\027\036)Tj 0 Tw (-)Tj 0.151 Tw T* [(\027\017\016\n\017 )0.6(\023\030\024\n\036\032\027\024\f\021\017 )0.5(\235\024\030\n\017\030\024\r\026\035\026\f\034 )0.6(\023\030\024\022\f\017\n\026\035\034\027\026\016 )]TJ 0.193 Tw T* (\f\021\024\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\026\r\035\017\r\026\035\f\016 \031\030\036\021\030\026\ \035\034\027\t\005 \022\026\021\036\021\036\030, \035\017\002\024 )Tj 0.67 Tw T* (\235\024\030\n\017\030\024\r\026\035\026\f\034 \006\017\f\021\024\f\021\024\ \n\026 [22]. \205\024\030\n\017\030\024\r\026\027\017\036 )Tj 0.607 Tw T* (\023\030\024\022\f\017\n\026\035\034\027\024\005 \f\021\024\n\t \023\030\ \036\007\024\021\r\030\026\013\026\036\021 \023\024\023\026\007\026\027\017\ \036 )Tj 0.329 Tw T* [(\022\017\001\036\004\027\024\020\024 )0.6(\f\024\007\036\030\032\017\n\024\020\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.143 0 Td [(\024\002\035\026\f\021\034 )0.5(\030\026\027\t )0.6(\023\030\024\n\036\032)]TJ 0 Tw (-)Tj 0.206 Tw -12.143 -1.218 Td (\027\024\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \027\026\035\017\004\017\017 \023\024\r\030\036\032\007\036\ \027\017\016 \r\027\036\002\030\033\001\017\027\027\024\005 )Tj 0.119 Tw T* (\004\026\f\021\017 \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \023\026\030\026\030\036\022\021\026\035\034\027\031\033 \022\035\036\ \021\004\026\021\022\031. )Tj 0.028 Tw T* (\210\023\017\f\t\r\026\036\021\f\016 \235\024\030\n\017\030\024\r\026\027\ \017\036 \022\026\022 \022\024\027\006\036\r\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\021)Tj 0 Tw (-)Tj 0.148 Tw T* (\035\036\r\024\005 \f\021\024\n\t, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \022\024\027\006\036\r\026\016 \f\021\024\n\026, \004\026\ \013\036 \r\f\036\020\024, )Tj 0.208 Tw T* (\235\024\030\n\017\030\031\036\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\021\030\031\022\021\017\r\027\t\b \030\036\036\022\006\017\016\ \b \022\017\001\022\017. )Tj -0.045 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC 0.733 0 Td [(\024\f\021\026\035\034\027\t\b )0.5(\f\035\031\004\026\016\b )0.5(\023\030\036\007\023\024\004\021\036\027\017\036 )0.5(\024\021\007\026\036\021\f\016 )0.5(\023\036\021\035\036\r\024\005 )]TJ 0 Tw -0.733 -1.218 Td (\f\021\024\n\036)Tj /Span<>> BDC ( )Tj EMC ([1,2,7,23].)Tj 0.019 Tw T* (\200 \f\021\026\021\034\016\b, \023\024\f\r\016\013\201\027\027\t\b \021\ \030\026\r\n\026\n \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 0.367 Tw T* (\001\017\030\027\t\n \030\026\027\026\n \023\030\024\n\036\032\027\024\f\ \021\017, \023\024\035\031\004\036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030)Tj 0 Tw (-)Tj 0.149 Tw T* [(\027\024\036 \r\030\036\n\016, \024\021\n\036\004\026\036\021\f\016 )0.5(\002\024\035\036\036 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\ \027\027\t\005 )]TJ 0.114 Tw T* (\023\024\007\b\024\007 \022)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\033 \f\021\024\n\t. \025\026\022\ \023\030\026\r\017\035\024, \f\021\024\n\031 )Tj 0.455 Tw T* (\030\036\022\024\n\036\027\007\031\033\021 \235\024\030\n\017\030\024\r\026\ \021\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\r\n\026\b \023\030\024\n\036\032)Tj 0 Tw (-)Tj 0.238 Tw T* (\027\024\f\021\017, \f\024\004\036\021\026\033\013\017\b\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \r\027\036\002\030\033\001\017\ \027)Tj 0 Tw (-)Tj 0.183 Tw T* (\027\024\005 \004\026\f\021\017 \023\030\016\n\024\005 \022\017\001\022\017\ . \210\007\027\026\022\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n, \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 )Tj 0.116 Tw T* (\f\035\031\004\026\036\r \027\036\022\024\021\024\030\t\036 \026\r\021\024\ \030\t \031\022\026\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036 )Tj 0.063 Tw 23.244 64.543 Td [(\027\036\024\002\b\024\007\017\n\024\f\021\017 )0.6(\235\024\030\n\017\030\024\r\026\027\017\016 )0.6(\f\021\024\n\t, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 16.878 0 Td [(\007\030\031\020\026\016 )0.5(\004\026\f\021\034 )]TJ 0.249 Tw -16.878 -1.218 Td (\026\r\021\024\030\024\r \r\f\201-\021\026\022\017 \027\026\f\021\026\017\ \r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 )Tj 0.291 Tw T* (\022\024\035\024\f\021\024\n\017\017 [6,8,15,19]. \231\026\f\021\034 \b\017\ \030\031\030\020\024\r \023\030\017\007\036\030\032\017)Tj 0 Tw (-)Tj 0.414 Tw T* [(\r\026\033\021\f\016 \017\027\007\017\r\017\007\031\026\035\034\027\024\020\ \024 )0.5(\023\024\007\b\024\007\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\031\033\021 )Tj 0.202 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\036 \f\021\024\n\t \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\024\005 \030\026\027\036 \023\030\024\n\036\032\ )Tj 0 Tw (-)Tj 0.125 Tw T* (\027\024\f\021\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\b \007\036\235\036\022\021\026\b \f\021\036\027\ \022\017 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 )Tj 0.083 Tw 0 -1.218 TD [(\030\026\r\017\r\001\036\n\f\016 )0.5(\023\036\030\017\021\024\027\017\021\036. )0.5(\212\036\n\017\007\024\r)]TJ /Span<>> BDC ( )Tj EMC (\200.\202. \017)Tj /Span<>> BDC ( )Tj EMC 17.924 0 Td (\f\024\026\r\021. \030\036)Tj 0 Tw (-)Tj 0.255 Tw -17.924 -1.218 Td (\022\024\n\036\027\007\031\033\021 \235\024\030\n\017\030\024\r\026\021\034\ \f\017\020\n\024\f\021\024\n\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\016\b )Tj 0.11 Tw 0 -1.218 TD [(\r\027\036\002\030\033\001\017\027\027\024\005 )0.6(\004\026\f\021\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\f\021\030\024\020\024 )0.5(\017\027\007\017\r\017)]TJ 0 Tw (-)Tj -0.009 Tw T* (\007\031\026\035\034\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \b\026\030\026\022\021\036\030\ \026 \030\026\027\t, \f\035\024\032\027\024\f\021\017 )Tj 0.015 Tw T* [(\031\001\017\r\026\027\017\016, )0.6(\f\030\024\022\024\r )0.5(\023\024\r\030\036\032\007\036\027\017\016, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 14.333 0 Td [(\023\030\017 )0.5(\023\024\r\030\036\032\007\036\027\017\016\b )]TJ 0.053 Tw -14.333 -1.218 Td (\027\017\032\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\007\ \036\035\026 \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\024 \022\026\027\026\035\026 \027\036 \023\030\017\002\036\020\026\021\ \034 \022)Tj /Span<>> BDC ( )Tj EMC (\f\017\020\n\024\f\021\024\n\017\017 [15].)Tj 0.298 Tw 0 -1.218 TD [(\215\024\r\030\036\032\007\036\027\017\016 \r\027\036\002\030\033\001\017\ \027\027\024\005 )0.5(\004\026\f\021\017 \023\030\016\n\024\005 )0.5(\022\017\001\022\017 )]TJ -0.013 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\036\r\024\005 \021\030\026\r\n\036, \f\024\020\035\026\f\027\024\ \f\021\030\026\021\036\020\017\017 4D, \027\036\024\002\b\024\007\017)Tj 0 Tw (-)Tj 0.116 Tw T* [(\n\024 \031\f\021\030\026\027\016\021\034. \211\f\021\030\026\027\036\027\ \017\036 )0.5(\r\t\023\024\035\027\016\036\021\f\016 \023\024\f\030\036\007\f\021\r\024\ \n )]TJ 0.276 Tw T* (\024\002\f\021\030\031\022\021\017\r\027\024\005 \030\036\036\022\006\017\ \017 \023\030\016\n\024\005 \022\017\001\022\017 \017\035\017 \023\031\021\ \036\n )Tj -0.034 Tw T* (\031\001\017\r\026\027\017\016 \007\036\235\036\022\021\026 \f\021\036\027\ \022\017 \022\017\001\022\017. \211\001\017\r\026\027\017\036 \030\036\022\ \024\n\036\027)Tj 0 Tw (-)Tj 0.258 Tw T* (\007\031\033\021 \023\030\024\017\r\024\007\017\021\034 \021\030\026\027\ \f\026\027\026\035\034\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0.05 Tw T* (\030\036\022\021\026\035\034\027\t\b \036\030\022\026\035, \036\f\035\017\ \007\036\235\036\022\021 \f\021\036\027\022\017 \023\030\016\n\024\005 \ \022\017\001)Tj 0 Tw (-)Tj 0.17 Tw T* (\022\017 \027\026\b\024\007\017\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \f\026\027\021\017\n\036\021\030\024\r \024\021 \026\007)Tj 0 Tw (-)Tj 0.074 Tw T* (\027\036\020\024 \023\030\024\b\024\007\026 [15,16,17,21]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\001\017\030\027\t\b \007\036\235\036\022\021\026\b )Tj 0.282 Tw T* [(\f\021\036\027\022\017 \022\017\001\022\017 \023\030\024\r\024\007\017\021\ \f\016 \024\002\f\021\030\031\022\021\017\r\027\026\016 )0.5(\030\036\036\022\006\017\016 )]TJ 0.092 Tw T* (\017\035\017 \220\022\f\021\017\030\023\026\006\017\016 \023\030\016\n\024\ \005 \022\017\001\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\f\f\017\r\027\024\n \023\024)Tj 0 Tw (-)Tj 0.141 Tw T* (\r\030\036\032\007\036\027\017\017 \f\235\017\027\022\021\036\030\027\024\ \020\024 \026\023\023\026\030\026\021\026, \021\026\022\032\036 \030\036\ \022\024\n\036\027)Tj 0 Tw (-)Tj 0.008 Tw T* [(\007\031\036\021\f\016 )0.5(\220\022\f\021\017\030\023\026\006\017\016 \023\030\016\n\024\005 )0.5(\022\017\001\022\017 [1,24]. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 )Tj 0.447 Tw T* [(\030\016\007\026 \017\f\021\024\004\027\017\022\024\r, )0.5(\023\024\f\r\016\013\201\027\027\t\b \021\030\026\r\n\026\n )0.5(\n\017\030\027\024\020\024 )]TJ 0.176 Tw T* (\r\030\036\n\036\027\017, \023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\016\n\017 \023\030\024\n\036\032\027\024\f\021\017\ , \f\024)Tj 0 Tw (-)Tj 0.083 Tw T* (\004\036\021\026\033\013\017\n\017\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \r\027\036\002\030\033\001\017\ \027\027\024\005 \004\026\f\021\017 )Tj 0.025 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017, \007\024\f\021\026\021\024\004\ \027\024 \023\030\024\r\024\007\017\021\034 \b\017\030\031\030\020\017\004\ \036\f\022\031\033 )Tj 0.002 Tw T* (\024\002\030\026\002\024\021\022\031 \030\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 \f\026\027\026\006\017\036\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024)Tj 0 Tw (-)Tj 0.046 Tw T* (\r\026\027\017\036\n \030\026\027\t \023\024\007 \023\030\017\022\030\t\021\ \017\036\n \023\030\024\022\f\017\n\026\035\034\027\024\005 \f\021\024\n\ \t, )Tj 0.229 Tw T* (\002\036 \031\001\017\r\026\027\017\016 \007\036\235\036\022\021\026 \f\ \021\036\027\022\017 \022\017\001\022\017. \217\016\007 \026\r\021\024\030\ \024\r )Tj -0.025 Tw T* [(\027\026\f\021\026\017\r\026\036\021 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.945 0 Td [(\024\002\016\026\021\036\035\034\027\024\n )0.6(\031\001\017\r\026\027\017\017 )0.5(\007\036\235\036\022\021\024\r )0.6(\r\027\036)]TJ 0 Tw (-)Tj 0.07 Tw -5.945 -1.218 Td (\002\030\033\001\017\027\027\024\005 \004\026\f\021\017 \023\030\016\n\024\ \005 \022\017\001\022\017, \004\021\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\b \n\027\036\027\017\033, )Tj 0.17 Tw T* (\023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\026\007\201\032\027\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\n\031 \026\032\017\r\035\036)Tj 0 Tw (-)Tj 0.13 Tw T* [(\027\017\033 \007\036\235\036\022\021\026 [8,15,16,19]. Her)-24(zig)]TJ /Span<>> BDC ( )Tj EMC (D.O., \024\021\n\036\004\026\036\021, \004\021\024 )Tj -0.011 Tw T* (\006\036\035\036\f\024\024\002\030\026\027\t\n \f\004\017\021\026\036\021\ \f\016 \031\001\017\r\026\027\017\036 \007\036\235\036\022\021\024\r \026\ \027\017)Tj 0 Tw (-)Tj 0.052 Tw T* (\n\026\033\013\017\b \027\036 \002\024\035\036\036 50% \023\024\035\031\024\ \022\030\031\032\027\024\f\021\017 \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.181 Tw T* (\022\017 [17]. \221\031\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\230. \024\021\n\036\004\026\036\021, \004\021\024 \031\001\017\r\026\ \027\017\036 \030\026\027\t )Tj -0.012 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \031\007\024\002\027\036\036\ \023\030\024\r\024\007\017\021\034 \f\024 \f\021\024\030\024\027\t \036\ \036 \023\030\024)Tj 0 Tw (-)Tj 0.071 Tw T* (\f\r\036\021\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\026\021\024\004\027\024\005 \030\036\035\026\022\f\026\006\ \017\017 \f\235\017\027\022\021\036\030\026 \n\024\032)Tj 0 Tw (-)Tj 0.025 Tw T* [(\027\024 \031\001\017\021\034 \030\026\027\031 \023\030\016\n\024\005 )0.5(\022\017\001\022\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\026\f\f\021\024\016\027\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \f\n )Tj 0 Tw T* (\024\021 \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 [\ 15].)Tj 0.523 Tw T* (\212\017\f\021\026\035\034\027\024\036 \023\030\024\n\t\r\026\027\017\036\ \030\036\022\024\n\036\027\007\031\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.457 Tw T* (\031\007\026\035\036\027\017\016 \024\f\021\026\021\022\024\r \022\026\035\ \024\r\t\b \n\026\f\f, \022\024\021\024\030\t\036 \n\024\020\031\021 )Tj 0.348 Tw T* (\f\021\026\021\034 \023\030\017\004\017\027\024\005 \f\036\023\021\017\004\ \036\f\022\017\b \024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.421 Tw T* [(\023\026\007\026\027\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\027\031 \023\030\024\n\036\032\027\024\f\021\017 )0.5(\017\035\017 )0.5(\004\036\030\036 )0.5(\007\036\235\036\022\021 )]TJ 0.145 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\031\033 \022\035\036\021\ \004\026\021\022\031. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 )Tj 0.341 Tw T* (\024\004\036\030\036\007\034, \002\t\035\024 \r\t\f\022\026\026\027\024\ \n\027\036\027\017\036, \004\021\024 \007\017\f\021\026\035\034\027\024\ \036 )Tj 0.097 Tw T* (\023\030\024\n\t\r\026\027\017\036 \n\024\032\036\021 \023\030\017\r\036\ \f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\016\021\030\024\020\036\027\027\024\n\031 \023\024\023\026\007\026)Tj 0 Tw (-)Tj 0.15 Tw T* [(\027\017\033 )0.5(\022\026\035\026 \r)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\035\024\f\021\034 )0.5(\021\026\026 )0.5(\004\036\030\036 \007\036\235\036\022\021 )0.5(\f\021\036\027\022\017 )0.5(\022\017\001)]TJ 0 Tw (-)Tj 0.167 Tw T* [(\022\017, \036\f\035\017 \024\027 \036\013\201 \027\036 \002\t\035 \031\f\ \021\030\026\027\201\027, )0.5(\004\021\024 \021\026\022\032\036 \n\024\032\036\021 )]TJ 0.157 Tw T* [(\023\030\017\r\036\f\021\017 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\f\036\023\021\017\004\036\f\022\017\n )0.5(\024\f\035\024\032\027\036\027\017\016\n )0.5([21]. \200)]TJ /Span<>> BDC ( )Tj EMC (\f\r\024\033 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_2 1 Tf 25 0 0 25 19.9527 56.0378 Tm (118)Tj ET endstream endobj 475 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 343.4568 42.7216 Tm [(Sur)31(ger)-30.9(y of militar)-31(y injuries of th)11(e perineum $r)31(e)11(vie)11(w$)]TJ -40.125 0 Td [(\224\b\017\220\017\020\b\213\f\205\007\005 \026)11(\005\007)-10(\026\b\007\005 \013\f\213\f\t\b \223\005\216\b\f\t\026)11.1(\025\016 \205\022\210\025\f\016\240\024\b )]TJ 0 -1 TD [(\017\005\t\f\t\b\024\b \223\017\025\024\f\235\t\025\205)-10(\026\b $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-19.9(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.083 Tw 10 0 0 10 42.5197 724.8299 Tm (\217\026\027\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016, \022\026\022 \023\030\026\r\017\ \035\024, )Tj 0.053 Tw 0 -1.218 TD [(\f\017\035\034\027\024 )0.5(\024\021\035\017\004\026\033\021\f\016 )0.5(\024\021 )0.5(\030\026\027\036\027\017\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\r\024\036\027\027\024\036 )0.6(\r\030\036\n\016. )0.5(\230-)]TJ 0.232 Tw T* (\026 \024\021\f\031\021\f\021\r\017\016 \n\017\027\027\024-\r\030\t\r\027\ \024\020\024 \b\026\030\026\022\021\036\030\026 \023\024\r\030\036\032)Tj 0 Tw (-)Tj 0.104 Tw T* (\007\036\027\017\005 \027\036 \024\021\n\036\004\026\036\021\f\016 \n\026\ \f\f\017\r\027\t\b \030\026\030\031\001\036\027\017\005 \n\016\020\022\017\ \b )Tj 0.276 Tw T* (\021\022\026\027\036\005 \023\030\024\n\036\032\027\024\f\021\017; \n\036\ \027\036\036 \r\t\030\026\032\036\027\t \027\036\022\030\024\021\017\004\ \036)Tj 0 Tw (-)Tj 0.05 Tw T* [(\f\022\017\036 )0.5(\017\n\036\027\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.71 0 Td [(\026\020\030\016\027\201\027\027\024\f\021\034 )0.5(\030\026\027\t )0.5(\036\n\035\201\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 13.083 0 Td (\030\026)Tj 0 Tw (-)Tj -0.055 Tw -20.793 -1.218 Td (\027\016\013\017\n\017 \026\020\036\027\021\026\n\017; \017\n\036\036\021\ \f\016 \n\036\027\034\001\026\016 \f\021\036\023\036\027\034 \022\030\024\ \r\024\023\024)Tj 0 Tw (-)Tj 0.011 Tw T* (\021\036\030\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC 4.271 0 Td [(\220\021\024\n \024\021\f\031\021\f\021\r\031\036\021 )0.5(\b\026\030\026\022\021\036\030\027\026\016 )0.5(\007\035\016 \030\026\027\036\027\017\005, )]TJ 0.036 Tw -4.271 -1.218 Td (\023\024\035\031\004\036\027\027\t\b \r\024 \r\030\036\n\016 \002\024\036\ \r\t\b \007\036\005\f\021\r\017\005, \024\027\026 \r\021\024\030\017\004\ )Tj 0 Tw (-)Tj 0.01 Tw T* (\027\024\020\024 \027\036\022\030\024\026 $\n\024\035\036\022\031\035\016\ \030\027\024\020\024 \f\024\021\030\016\f\036\027\017\016$, \235\024\030\ \n\017\030\031)Tj 0 Tw (-)Tj -0.031 Tw T* (\033\013\026\016\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \r\024\022\030\031\020 \030\026\027\036\r\024\020\ \024 \022\026\027\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 )Tj 0.16 Tw T* (\r\024\007\036\005\f\021\r\017\016 \022\017\027\036\021\017\004\036\f\022\ \024\005 \220\027\036\030\020\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\024\r\026\027\017\036\n )Tj 0.25 Tw 0 -1.218 TD [(\r\030\036\n\036\027\027\024\005 )0.5(\023\031\035\034\f\017\030\031\033\013\036\005 )0.6(\023\024\035\024\f\021\017. )0.6(\237\021\026 )0.5(\024\027\026 )0.5(\024\023\026\f)]TJ 0 Tw (-)Tj 0.227 Tw 0 -1.218 TD (\027\026 \007\026\035\034\027\036\005\001\017\n \030\026\r\017\021\017\036\ \n \027\036\022\030\024\026 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \024\002\035\026\f\021\017 )Tj 0.146 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC 0.896 0 Td [(\023\024\r\t\001\036\027\027\t\n )0.5(\030\017\f\022\024\n )0.6(\030\026\r\017\021\017\016 )0.5(\017\027\235\036\022\006\017\024\027\027\t\b )0.6(\024\f)]TJ 0 Tw (-)Tj 0.128 Tw -0.896 -1.218 Td (\035\024\032\027\036\027\017\005 [13,14]. \025)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\030\031, \224\024\021\017\022\024\r \200.\003. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.127 Tw T* (\024\023\017\f\t\r\026\036\021 \027\036\024\002\030\026\021\017\n\t\036 \ \023\026\021\024\035\024\020\017\004\036\f\022\017\036 \017\n\036\027\036\ \027\017\016, )Tj 0.287 Tw T* (\024\002\027\026\030\031\032\036\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \220\035\036\022\021\030\024\027\027\024\005 \ \n\017\022\030\024\f\022\024)Tj 0 Tw (-)Tj 0.194 Tw T* (\023\017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\036 \021\024\035\f\021\024\005 \022\017\001\022\017 \023\ \024\f\035\036 \024\020\027\036\f\021\030\036\035\034\027\024\020\024 )Tj 0.236 Tw T* [(\030\026\027\036\027\017\016, )0.6(\022\024\021\024\030\t\036 )0.5(\030\026\f\023\030\024\f\021\030\026\027\016\035\017\f\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 17.443 0 Td [(9 )0.5(\f\026\027\021\017\n\036)]TJ 0 Tw (-)Tj 0.149 Tw -17.443 -1.218 Td (\021\030\024\r \024\021 \030\026\027\036\r\024\020\024 \022\026\027\026\035\ \026 [28]. \210\023\017\f\026\027\027\t\036 \030\026\035\017\004\017\016\ )Tj 0.143 Tw T* (\023\030\017\r\036\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\033 \023\024\007\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.355 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\030\036\032\007\036\027\017\016\n\017 \023\030\024\n\036\032\027\ \024\f\021\017, )0.5(\023\024\035\031\004\036\027\027\t\n\017 )]TJ 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\r\n\026\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 408.2018 Tm (\017\034\r\236)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.052 Tw 10 0 0 10 42.5197 383.8458 Tm (\037\036\035\034\033 \007\026\027\027\024\005 \030\026\002\024\021\t \f\021\ \026\035\024 \023\030\036\007\f\021\026\r\035\036\027\017\036 \027\026\030\ \030\026\021\017\r)Tj 0 Tw (-)Tj 0.081 Tw T* (\027\024\020\024 \024\002\024\030\026 \024\023\017\f\026\027\027\024\005\ \023\030\024\002\035\036\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\017\036\n )Tj 0.099 Tw T* (\007\026\027\027\t\b \024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\026\b \030\026\027\036\027\017\005 \023\030\024\ \n\036\032\027\024\f\021\017 )Tj -0.038 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\036\027\027\024\036 \r\030\036\n\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \220\r\024\035\033\006\017\017 \n\036\021\024\007\024\ \r )Tj 0 Tw T* (\035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\201\027\027\t\b \023\024\f\035\036\007\f\021\r\017\005\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 298.5998 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.222 Tw 10 0 0 10 42.5197 274.2438 Tm [(\212\035\016 \026\027\026\035\017\026 \035\017\021\036\030\026\021\031\030\ \t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\b\024\007\036 \027\026\023\017\f\026\027\017\016 )0.5(\007\026\027\027\024\005 )]TJ 0.137 Tw T* (\f\021\026\021\034\017 \002\t\035 \024\f\031\013\036\f\021\r\035\036\027\ \023\024\017\f\022 \035\017\021\036\030\026\021\031\030\027\t\b \017\f\021\ \024\004)Tj 0 Tw (-)Tj 0.234 Tw T* (\027\017\022\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \203\026\031\004\027\024\005 \220\035\036\022\ \021\030\024\027\027\024\005 \002\017\002\035\017\024\021\036)Tj 0 Tw (-)Tj 0.272 Tw T* [(\022\017 eLIBRAR)-14(Y.R)12(U \017)]TJ /Span<>> BDC ( )Tj EMC [(\017\027\235\024\030\n\026\006\017\024\027\027\024\005 \002\026\t P)20.1(ubMed.)]TJ 0.188 Tw T* (gov \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\n \f\035\024\r\026\n: \253\030\026\027\036\027\017\ \016 \023\030\024\n\036\032\027\024\f\021\017\273, )Tj 0.339 Tw T* [(\253\030\026\027\036\027\017\016 )0.5(\023\030\016\n\024\005 \022\017\001\022\017\273, \253\021\030\026\r\n\026\ \023\030\024\n\036\032\027\024\f\021\017\273, )]TJ 0.143 Tw T* [(\253per)-37(ineum injur)-24(y\273, \253r)-24(ec)-16(t)15(al injur)-37(ies\273, \253per)-37(ineum tr)-32.9(au)]TJ 0 Tw (-)Tj 0.287 Tw T* [(ma\273. )0.5(\215\030\036\r\026\035\017\030\031\033\013\017\005 )0.6(\023\024\017\f\022 )0.5(\007\026\027\027\t\b )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 17.739 0 Td (\023\024\f\035\036\007\027\017\036 )Tj 0 Tw -17.739 -1.218 Td (10)Tj /Span<>> BDC ( )Tj EMC (\035\036\021.)Tj /T1_3 1 Tf 0.753 Tw 0 -2.436 TD [(\203\022\037\013\020\034\024\035\022\021\037 )0.6(\033\037\020\016\020\022\t )0.5(\f\033\034\b\016\003\020\034\024\035\022 )0.6($\037\027\013\034\033\022\035\b )]TJ 0 Tw 0 -1.218 TD (\034\025\024\027\016\005\034\036\037\020\022\030$.)Tj /T1_1 1 Tf 0.206 Tw T* (\215\030\017 \n\017\027\027\024-\r\030\t\r\027\t\b \030\026\027\036\027\ \017\016\b \023\030\024\n\036\032\027\024\f\021\017 \002\024\035\034)Tj 0 Tw (-)Tj 0.118 Tw T* (\001\026\016 \004\026\f\021\034 \026\r\021\024\030\024\r \024\023\017\f\t\ \r\026\036\021 \n\026\f\f\017\r\027\t\036 \023\024\r\030\036\032\007\036\ )Tj 0 Tw (-)Tj 0.249 Tw T* (\027\017\016 \n\016\020\022\017\b \021\022\026\027\036\005 \024\002\035\026\ \f\021\017 \023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\027)Tj 0 Tw (-)Tj 0.133 Tw T* (\f\017\r\027\t\036 \002\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \030\026\027\t. \207\024\035\034\001\017\027\f\ \021\r\024 \026\r\021\024\030\024\r )Tj 0.146 Tw T* (\027\026\f\021\026\017\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\t\023\024\035\027\036\027\017\017 )0.5(\023\026\035\034\006\036\r\024\020\024 \030\036\022\021\026\035\034\027\024\ \020\024 )]TJ 0.494 Tw 23.244 64.543 Td (\017\f\f\035\036\007\024\r\026\027\017\016, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (33% \023\024\r\024\035\016\036\021 \024\023\030\036\007\036\035\017\021\ \034 )Tj 0.333 Tw T* (\023\024\r\030\036\032\007\036\027\017\036 \023\030\016\n\024\005 \022\017\ \001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \027\026\035\017\004\017\017 [1]. )Tj 0.198 Tw T* (\203\026\035\017\004\017\036 \022\030\024\r\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 \023\024\r\024\035\016\036\021\ \026\023\024\007\024)Tj 0 Tw (-)Tj -0.079 Tw T* [(\030\017\021\034 )0.5(\036\201 \023\024\r\030\036\032\007\036\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(80\22695% \f\035\031\004\026\036\r. )0.5(\200\t\023\024\035\027\036\027\017\036 )]TJ -0.003 Tw T* (\030\036\022\021\024\030\024\n\026\027\024\f\022\024\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (88% \023\024\r\024\035\016\036\021 \024\002\027\026\030\031\032\017\021\ \034 \030\026)Tj 0 Tw (-)Tj T* (\027\036\027\017\036 \023\030\016\n\024\005 \022\017\001\022\017 [1,6].)Tj -0.056 Tw 0 -1.218 TD (\210\002\024\030\027\026\016 \030\036\027\021\020\036\027\024\020\030\026\ \235\017\016 \002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\020\024 )Tj 0.046 Tw 0 -1.218 TD (\021\026\026 \023\024\r\024\035\016\036\021 \r\t\016\r\017\021\034 \027\ \026\035\017\004\017\036 \020\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024)Tj 0 Tw (-)Tj 0.035 Tw T* (\035\024\f\021\017, \027\026\035\017\004\017\036 \017\027\024\030\024\007\ \027\t\b \021\036\035 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\f\021\017 \n\026\035\024\020\024 \021\026\026 )Tj -0.038 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r \n\016\020\022\017\b \021\022\026\027\016\b \023\030\024\n\036\032\027\ \024\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024\r\030\036\032\007\036\027\017\016 )Tj 0.096 Tw T* [(\022\024\f\021\036\005 \021\026\026 )0.5([8]. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\036\r\024\n\024\032\027\024\f\021\017 \023\030\024\f\035\036\007\017\ \021\034 )0.5(\030\026)]TJ 0 Tw (-)Tj T* (\027\036\r\024\005 \b\024\007 \030\036\022\024\n\036\027\007\031\036\021\ \f\016 \r\031\035\034\027\036\030\024\020\030\026\235\017\016 [15].)Tj 0.002 Tc 0.527 Tw T* [(\215\024 \007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \030\ \036\022\024\n\036\027\007\031\033\021 \023\030\024\r\024\007\017\021\034\ )2( )]TJ 0.317 Tw T* (\022\024\n\023\034\033\021\036\030\027\031\033 \021\024\n\024\020\030\026\ \235\017\033 \024\030\020\026\027\024\r \002\030\033\001\027\024\005 \023\ \024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.117 Tw T* (\035\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\020\024 \021\026\026, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\026\f\021\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.323 Tw T* (\030\024\r\026\027\017\036\n [6,16,17]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n \017\f\f\035\036\007\024\r\026\027\ \017\016)2( )]TJ 0.135 Tw T* [(Br)-32(o)-16(gden)]TJ /Span<>> BDC ( )Tj EMC (T.G., \022\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\ \026\235\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\007\r\024\005\027\t\n)2( )]TJ 0.278 Tw T* [(\022\024\027\021\030\026\f\021\017\030\024\r\026\027\017\036\n )0.5(\024\002\035\026\007\026\036\021 )0.5(100% )0.5(\004\031\r\f\021\r\017\021\036\035\034\027\024)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.112 Tw T* (\f\021\034\033 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\030\036\032\007\036\027\017\016\n \023\030\016\n\024\005 \022\ \017\001\022\017)2( )]TJ -0.028 Tw T* [([1]. \237\021\024 \023\024\r\024\035\016\036\021 \024\002\027\026\030\031\ \032\017\021\034 \007\036\235\036\022\021 \f\021\036\027\022\017 \023\030\ \016\n\024\005)2( )]TJ 0.139 Tw T* (\022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\016 \007\030\031\020\017\b \024\030\ \020\026\027\024\r, \023\036\030\036\035\024\n \022\024)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.168 Tw T* (\f\021\036\005 \021\026\026, \017\027\024\030\024\007\027\t\036 \021\036\ \035\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 \023\030\024\n\036\032\027\024\f\021\017,)2( )]TJ 0.285 Tw T* (\020\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\ \004\026\021\022\036, \020\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\r\024\002\024\007\027\031\033)2( )]TJ 0.068 Tw T* (\032\017\007\022\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017. \200\t\016\r\035\ \036\027\017\036 \020\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.005 Tw T* (\030\026\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\004\026\ \021\022\036 \016\r\035\016\036\021\f\016 \f\026\n\t\n \004\026\f\021\t\n\ \023\030\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.225 Tw T* [(\027\026\022\024\n \023\024\r\030\036\032\007\036\027\017\016 \r\027\036\ \002\030\033\001\017\027\027\024\005 \004\026\f\021\017 \023\030\016\n\024\ \005)2( )]TJ 0 Tw T* (\022\017\001\022\017 [1].)Tj 0 Tc 0.078 Tw T* [(\215\030\017 )0.5(\023\024\007\024\030\036\027\017\017 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.465 0 Td [(\021\030\026\r\n\031 )0.5(\n\024\004\036\017\f\023\031\f\022\026\021\036\035\034\027\024\020\024 )0.7(\022\026)]TJ 0 Tw (-)Tj -0.004 Tw -8.465 -1.218 Td (\027\026\035\026 \017\035\017 \n\024\004\036\r\024\020\024 \023\031\t\030\ \016, \030\036\022\024\n\036\027\007\031\036\021\f\016 \r\t\023\024\035\027\ \016\021\034 )Tj 0 Tw T* (\030\036\021\030\024\020\030\026\007\027\031\033 \031\030\036\021\030\024\ \020\030\026\235\017\033 \017\035\017 \006\017\f\021\024\020\030\026\235\ \017\033 [6].)Tj /T1_3 1 Tf 0 -2.436 TD (\200\037\021\035\022\021\037 \001\022\033\023\033\013\022\n\016\024\021\034\ \013\034 \027\016\n\016\020\022\030.)Tj /T1_1 1 Tf 0.398 Tw 0 -1.218 TD [(\224\026\022\021\017\022\026 \b\017\030\031\030\020\017\004\036\f\022\024\ \020\024 )0.5(\035\036\004\036\027\017\016 \002\024\036\r\t\b \030\026\027\036\027\017\ \005 )]TJ -0.031 Tw T* (\023\030\024\n\036\032\027\024\f\021\017, \f\024\004\036\021\026\033\013\ \017\b\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \023\030\016\n\024\005 )Tj 0.161 Tw T* (\022\017\001\022\017, \017\n\036\027\016\035\026\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036\n \r\030\036\n\036\027\017. \212\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 )Tj 0.1 Tw T* (\n\017\030\024\r\024\005 \r\024\005\027\t \021\026\022\017\b \030\026\027\ \036\027\t\b \035\036\004\017\035\017 \022\024\027\f\036\030\r\026\021\017\ \r)Tj 0 Tw (-)Tj 0.172 Tw T* (\027\024, \026)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\034 \007\024\f\021\017\020\026\035\ \026 90%. \200\024 \r\030\036\n\016 \023\036\030\r\024\005 )Tj 0.023 Tw T* [(\n\017\030\024\r\024\005 \r\024\005\027\t \r\t\002\024\030\024\004\027\024\ \235\024\030\n\017\030\024\r\026\035\017 )0.5(\024\021\r\024\007\016\013\031\033 )]TJ 0.032 Tw T* [(\f\021\024\n\031, \035\036\021\026\035\034\027\024\f\021\034 \f\024\f\021\ \026\r\035\016\035\026 )0.5(70%. )0.5(\200\024 \r\030\036\n\016 \r\021\024\030\024\005 )]TJ -0.053 Tw T* (\n\017\030\024\r\024\005 \r\024\005\027\t \235\024\030\n\017\030\024\r\026\ \035\017 \f\021\024\n\t \r\f\036\n \021\026\022\017\n \030\026\027\036)Tj 0 Tw (-)Tj 0.179 Tw T* (\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\035\017 \007\030\036\027\017\030\024\r\ \026\027\017\036 )0.5(\023\030\036\f\026\022\030\026\035\034\027\024\020\024 )]TJ 0.151 Tw T* [(\023\030\024\f\021\030\026\027\f\021\r\026, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.976 0 Td [(\030\036\031\035\034\021\026\021\036 )0.6(\004\036\020\024 )0.5(\035\036\021\026\035\034\027\024\f\021\034 )0.6(\f\027\017\017)]TJ 0 Tw (-)Tj 0.047 Tw -6.976 -1.218 Td (\035\026\f\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (36%. \200\024 \r\030\036\n\016 \r\024\005\027\t \r\024 \200\034\036\021\027\ \026\n\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj 0.23 Tw T* (\027\017\017 \030\026\027\036\027\017\005 \023\030\024\n\036\032\027\024\ \f\021\017 \017\f\023\024\035\034\024\r\026\035\026\f\034 \021\026\022\021\ \017\022\026 )Tj 0.052 Tw T* [(4D: Debr)-37(idement, Di)-16(ver)-9.9(sion, Dr)-33(aina)-17(ge, Dist)15(al l)-16(av)-15(a)-17(ge)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.354 Tw T* (\r\t\r\036\007\036\027\017\036 \024\021\r\024\007\016\013\036\005 \f\021\ \024\n\t, \031\f\021\030\026\027\036\027\017\036 \007\036\235\036\022\021\ \026 )Tj 0.051 Tw T* (\f\021\036\027\022\017 \022\017\001\022\017 $\023\030\017 \036\020\024 \ \027\026\035\017\004\017\017$, \007\030\036\027\017\030\024\r\026\027\017\ \036 \023\030\036)Tj 0 Tw (-)Tj 0.63 Tw T* (\f\026\022\030\026\035\034\027\024\020\024 \023\030\024\f\021\030\026\027\ \f\021\r\026, \007\017\f\021\026\035\034\027\024\036 \023\030\024\n\t\r\026\ )Tj 0 Tw (-)Tj 0.163 Tw T* (\027\017\036 \023\030\016\n\024\005 \022\017\001\022\017. \215\024)Tj /Span<>> BDC ( )Tj EMC 10.167 0 Td [(\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, )0.5(\035\036\021\026\035\034)]TJ 0 Tw (-)Tj 0.154 Tw -10.167 -1.218 Td (\027\024\f\021\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\n \n\036\021\024\007\036 \035\036\004\036\027\017\016 \f\ \027\017\017\035\026\f\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (17% )Tj -0.005 Tw T* ([2,17,18]. \210\007\027\026\022\024 \f\021\024\017\021 \023\030\017\027\ \026\021\034, \004\021\024 \021\026\022\024\036 \f\027\017\032\036\027\017\ \036 )Tj 0.105 Tw T* (\035\036\021\026\035\034\027\024\f\021\017 \f\r\016\026\027\024 \027\036\ \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\036\n \021\026\022\021\017)Tj 0 Tw (-)Tj 0.188 Tw T* (\022\017 \035\036\004\036\027\017\017, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f \f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\017\036\n \n\036\007\ \017\006\017\027\t )Tj 0.424 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \031\035\031\004\001\036\027\017\036\n \023\030\024\r\ \036\007\036\027\017\016 \220\r\026\022\031\026\006\017\024\027\027\t\b \ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 504.7145 56.0378 Tm (117)Tj ET endstream endobj 474 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 650.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 650.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 623.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 623.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 569.1763 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.023 Tw 9 0 0 9 119.0551 730.4919 Tm [(w)12(ounds receiv)13.1(ed in militar)-42.9(y actions.)]TJ 0.112 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: per)-37(ineal injur)-37(ies occur in app)46(ro)14(ximately 5.4% of cases of to)13(tal militar)-43(y actions. The most p)46(ressing )]TJ 0.153 Tw T* [(p)46(roblem is combined trauma of the e)-15(xtraper)-36.9(itoneal par)-40(t of the rectum. The g)12(enerally accep)13(ted concep)13(tion w)13(as )]TJ 0.059 Tw T* [(dev)13(eloped )0.6(dur)-36.9(ing )0.5(the )0.6(Vietnam )0.6(W)30(ar)51(. )0.6(Since )0.6(then, )0.6(the )0.6(app)46(roach )0.6(has )0.6(no)13(t )0.5(chang)12(ed )0.5(crucially)42(, )0.5(and )0.5(most )0.5(studies )0.5(are, )0.5(as )0.5(a )]TJ 0.023 Tw T* [(rule, descr)-36.9(ip)13(tiv)13(e in nature and do no)13(t p)46(rovide clear recommend)26.1(ations for treatment.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 675.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( per)-37(ineal injur)-43(y)42(, V)42.1(A)25.9(C system, e)-15(xtraper)-36.9(itoneal rectum, p)46(ro)14(ximal stoma, p)46(resacral drainag)12.1(e, distal w)13(ashout)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interests)Tj /T1_1 1 Tf 0.037 Tc 0.073 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.082 Tw 6.518 0 Td [( P)-4.2(e)-12.1(r)-19.1(e)-16.1(k)-16.8(h)-10.9(o)-20.4(d)-11.1(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-1.9(N)-2.8(.)-23.5(, O)-13(n)-5.7(n)-14(i)-15.8(t)-48.9(s)-22.9(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.4(.)0.5(E)-5.6(.)-23.5(, K)-11.2(o)-7.9(z)-15.8(l)-20.8(o)-10.4(v)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.8(.)-26.9(S)-9.6(.)-23.5(, K)-15.9(u)-22.8(z)-15.8(m)-14.5(i)-3.2(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)1.4(D)16.4(. S)-12.1(u)-7.6(r)-16.7(g)-14.4(e)-12.1(r)-60.6(y o)-12.1(f m)-14.5(i)-7.1(l)-16.6(i)-15.9(t)-36.7(a)-10.2(r)-60.6(y i)-3.2(n)-14.4(j)-3.5(u)-7.6(r)-56.4(i)-10.9(e)-22.8(s o)-12.1(f t)-26.1(h)-15.1(e p)-24.7(e)-12.1(r)-56.4(i)-3.2(n)-16.1(e)-14.1(u)-7(m $)39.2(r)-19.1(e)-15.8(v)-51.8(i)-11(e)-12.5(w)19.6($)10.4(.)23( )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw -6.523 -1.2 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)-1.4(5)23.3(;)9.8(2)8.8(4)-13.5($)37.7(1)44.3($)14.5(:)20.9(1)29.8(1)0.9(5)-22.7(\226)50.8(12)-2.3(2)1.9(. $)-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2($)10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.8(-)9.8(2)-9(0)-3.8(2)-1.4(5)-23.5(-)9.7(2)8.9(4)-28.6(-)55.2(1)26.9(-)55.1(1)29.7(1)0.9(5)-23.5(-)55.2(12)-2.3(2)]TJ /T1_1 1 Tf 0.011 Tc 0.344 Tw -7.014 -2.617 Td [(\021\024\027\030\026)5.3( \024\033\023)5.2( \215\030\027\030\215\032\026\037\032:)]TJ /T1_0 1 Tf 0.001 Tc 0.349 Tw 11.245 0 Td [( \r\023\031\007\b\022\020\034\036 \213\027\016\021\024\016\t \203\b\022\035\ \033\022\016\036\022\n, \233\231\230\211\207 \215\211 \253\255\034\024\024\ \022\t\024\021\022\t \023\020\022\036\016\033\024\022\035\016\035 \b\016\ \005\022\006\022\020\032\273 \240\022\020\031\005\033\037\036\037 \255\034\ \024\024\022\022,)1( )]TJ 0 Tc 0.023 Tw -11.25 -1.2 Td (\023\027.)Tj /Span<>> BDC ( )Tj EMC (\203\034\027\013\034\033\023\021\034\036\024\021\037\030, \005.)Tj /Span<>> BDC ( )Tj EMC (4, \240\034\024\021\036\037, 127006, \255\034\024\024\022\030; 8-903-568\ -89-55; e-mail: kuzminov3003@yandex.ru)Tj /T1_1 1 Tf 0.01 Tc 0.011 Tw 0.005 -1.2 Td [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.016 Tw 14.037 0 Td [( Alek)-23(sey D. K)17(uzminov)63(, R)22(ussian U)22(niv)13(ersity of)]TJ /Span<>> BDC ( )Tj EMC [(Medicine, Dolgoruk)13(ovsk)11.1(aya st., 4, Moscow)52.1(, 127006, R)22(ussia; 8-903-)]TJ 0.023 Tw -14.042 -1.2 Td [(568-89-55; e-mail: kuzminov3003@yande)-14.9(x.ru)]TJ 0 Tw 0 -2.792 TD (\203\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 18.09.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\201\034\024\027\016 \005\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\201\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.09.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 505.6259 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.471 Tw 10 0 0 10 70.8661 481.2699 Tm (\210\002\001\017\030\027\t\036 \030\026\027\036\027\017\016 \023\030\024\ \n\036\032\027\024\f\021\017 \016\r\035\016\033\021\f\016 \026\022\021\031\ )Tj 0 Tw (-)Tj 0.316 Tw 0 -1.218 TD (\026\035\034\027\024\005 \023\030\024\002\035\036\n\024\005 \f\024 \r\030\ \036\n\201\027 \r\024\005\027\t \r\024 \200\034\036\021\027\026\n\036 )Tj 0.512 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024 \023\024\035\031\004\017\035\017 \001\017\ \030\024\022\024\036 \030\026\f\023\030\024\f\021\030\026\027\036\027\017\ \036 )Tj 0.118 Tw T* (\f\030\036\007\017 \017\027\024\f\021\030\026\027\027\t\b \r\024\036\027\ \027\024\f\035\031\032\026\013\017\b \r\024 \r\030\036\n\016 \r\024\005\027\ )Tj 0.226 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\230\030\026\022\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\r \202\235\020\026\027\017\f\021\026\027\036. )0.5(\215\024\007\026\r\035\016\033\013\036\036 )0.5(\002\024\035\034\001\017\027)]TJ 0 Tw (-)Tj 0.12 Tw T* (\f\021\r\024 \220\021\017\b \030\026\027\036\027\017\005 \017\n\036\033\021\ \n\017\027\027\024-\r\030\t\r\027\024\005 \b\026\030\026\022\021\036\030\ )Tj 0.269 Tw T* (\023\024\r\030\036\032\007\036\027\017\016, \004\021\024 \f\r\016\026\027\ \024 \f)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\017\n \030\026\f\023\030\024\f\021\030\026)Tj 0 Tw (-)Tj 0.111 Tw T* (\027\036\027\017\036\n \n\017\027\027\024-\r\030\t\r\027\t\b \031\f\021\ \030\024\005\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\031\007\027\024\f\021\034\033 \017\b )Tj -0.046 Tw T* (\024\002\027\026\030\031\032\036\027\017\016 [1,2,3,4]. \224\026\022\032\ \036 \f\021\024\017\021 \024\021\n\036\021\017\021\034, \004\021\024 \r\026\ \032)Tj 0 Tw (-)Tj 0.041 Tw T* (\027\031\033 \030\024\035\034 \017\020\030\026\036\021 \024\021\f\031\021\ \f\021\r\017\036 \f\030\036\007\f\021\r \017\027\007\017\r\017\007\031\026\ \035\034\027\024\005 )Tj 0.112 Tw T* (\026\013\017\021\t \023\030\024\n\036\032\027\024\f\021\017. \207\t\035\ \024 \024\023\017\f\026\027\024 \017\f\023\024\035\034\024\r\026\027\017\ \036 )Tj 0.261 Tw T* (\002\030\017\021\026\027\f\022\017\n\017 \r\024\036\027\027\024\f\035\031\ \032\026\013\017\n\017 \f\030\036\007\f\021\r \017\027\007\017\r\017\007\ \031)Tj 0 Tw (-)Tj 0.01 Tw T* (\026\035\034\027\024\005 \026\013\017\021\t \023\030\024\n\036\032\027\024\ \f\021\017, \004\021\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\r\026\n \026\r\021\024\030\024\r, )Tj 0.011 Tw T* (\023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \022\024\035\017\004\036\f\021\r\026 \030\ \026\027\036\027\017\005 \023\030\024\n\036\032\027\024)Tj 0 Tw (-)Tj T* (\f\021\017 [5].)Tj 0.12 Tw T* (\230\f\f\035\036\007\024\r\026\027\017\016, \023\024\f\r\016\013\201\027\ \027\t\036 \002\024\036\r\t\n \030\026\027\036\027\017\016\n \023\030\024\ )Tj 0 Tw (-)Tj -0.055 Tw T* [(\n\036\032\027\024\f\021\017, )0.6(\027\024\f\016\021, )0.5(\022\026\022 )0.5(\023\030\026\r\017\035\024, )0.6(\024\023\017\f\026\021\036\035\034\027\t\005 )0.6(\b\026\030\026\022\021\036\030 )]TJ 0.094 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \007\026\033\021 \004\201\021\022\017\b \030\036\022\024\n\036\027\ \007\026\006\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.081 Tw T* (\027\t\n \024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\005, \007\024\035\016 \r\024\036\027\ \027\024\f\035\031\032\026\013\017\b )Tj 0.268 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\016\n\017 \023\030\024\n\036\032\027\ \024\f\021\017 \f\024\f\021\026\r\017\035\026 5,4% \024\021 )Tj 0.01 Tw T* (\r\f\036\020\024 \022\024\035\017\004\036\f\021\r\026 \030\026\027\036\027\ \t\b. \211\030\024\r\036\027\034 \035\036\021\026\035\034\027\024\f\021\017\ \f\030\036)Tj 0 Tw (-)Tj T* (\007\017 \220\021\017\b \030\026\027\036\027\t\b \f\024\f\021\026\r\035\016\ \035 47% [2].)Tj 0.008 Tc 0.79 Tw T* (\225\024\020\035\026\f\027\024 \035\017\021\036\030\026\021\031\030\027\t\ \n \007\026\027\027\t\n, \n\017\027\027\024-\r\030\t\r)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.353 Tw T* (\027\t\036 \030\026\027\036\027\017\016 \004\026\f\021\024 \023\030\017\r\ \024\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC [(\024\021\030\t\r\026\n \027\017\032\027\017\b)8( )]TJ 0.367 Tw T* (\022\024\027\036\004\027\024\f\021\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \031\030\024\r\027\016\b, \024\002\001\017\030\027\024\ \n\031 \023\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.356 Tw T* [(\r\030\036\032\007\036\027\017\033 \n\016\020\022\017\b \021\022\026\027\ \036\005 \024\002\035\026\f\021\017 \023\030\024\n\036\032\027\024\f\021\ \017,)8( )]TJ 0.077 Tw T* [(\023\024\r\030\036\032\007\036\027\017\033 )0.5(\027\026\030\031\032\027\t\b )0.5(\023\024\035\024\r\t\b )0.5(\024\030\020\026\027\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.125 0 Td (\f\235\017\027\022)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.466 Tw -19.125 -1.218 Td [(\021\036\030\027\024\020\024 \026\023\023\026\030\026\021\026 \023\030\016\ \n\024\005 \022\017\001\022\017, \023\024\r\030\036\032\007\036\027\017\016\ \n)8( )]TJ 0.187 Tw T* [(\024\030\020\026\027\024\r )0.5(\n\026\035\024\020\024 )0.5(\021\026\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.304 0 Td [(\022\024\f\021\036\005 )0.5(\021\026\026 )0.5([2,3,4,6]. )0.5(\225\021\024\017\021)8( )]TJ 0.422 Tw -10.304 -1.218 Td (\024\021\n\036\021\017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\036\030\027\017\026\006\017\036\005 \n\017\027\027\024-)Tj 0.259 Tw T* [(\r\030\t\r\027\t\b \031\f\021\030\024\005\f\021\r, \024\021\030\t\r\t \027\ \017\032\027\017\b \022\024\027\036\004\027\024\f\021\036\005)8( )]TJ 0.358 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \002\024\036\r\t\b \022\024\027\235\035\ \017\022\021\026\b \024\002\t\004\027\024 \023\030\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.143 Tw T* [(\017\f\b\024\007\016\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \r\t\001\036 \022\024\035\036\027\026. \215\024\r\ \030\036\032\007\036\027\017\016 \022\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.43 Tw T* [(\f\021\036\005 \021\026\026, \f\024\020\035\026\f\027\024 \017\f\f\035\036\ \007\024\r\026\027\017\016\n, \027\026\004\017\021\036\035\034\027\024)8( )]TJ 0.096 Tw 23.244 42.623 Td (\031\r\036\035\017\004\017\r\026\033\021 \035\036\021\026\035\034\027\024\ \f\021\034. \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \017\f\f\035\036\007\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.112 Tw T* [(\r\026\027\017\016 M)-24(ossadegh)]TJ /Span<>> BDC ( )Tj EMC (S. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021.)Tj /Span<>> BDC ( )Tj EMC [([3] \035\036\021\026\035\034\027\024\f\021\034 \f\030\036\007\017)8( )]TJ -0.032 Tw T* (\030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\036\n \030\026\027\036\027\017\016 \023\030\ \024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC 19.789 0 Td (\023\036\030\036)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.052 Tw -19.789 -1.218 Td (\035\024\n\026\n\017 \022\024\f\021\036\005 \021\026\026 \f\024\f\021\026\ \r\035\016\035\026 73%. \200)Tj /Span<>> BDC ( )Tj EMC [(\021\024 \032\036 \r\030\036\n\016,)8( )]TJ 0.293 Tw T* (\035\036\021\026\035\034\027\024\f\021\034 \f\030\036\007\017 \030\026\027\ \036\027\t\b \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\036\035\024\n\026\n\017)8.1( )]TJ 0.062 Tw T* (\021\026\026 \017\035\017 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\030\026\r\n\024\005 \023\030\024\n\036\032\027\024\f\021\017 \f\024\ \f\021\026\r\035\016\035\026)8( )]TJ 0.168 Tw T* (41% \017)Tj /Span<>> BDC ( )Tj EMC (18%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 [3]. \237\021\024 \ \020\024\r\024\030\017\021 \024)Tj /Span<>> BDC ( )Tj EMC (\f\036)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.03 Tw T* [(\030\034\201\027\024\n )0.5(\r\035\017\016\027\017\017 )0.5(\027\026\035\017\004\017\016 )0.5(\023\036\030\036\035\024\n\024\r )0.5(\022\024\f\021\036\005 )0.5(\n\026\035\024\020\024)8( )]TJ 0.047 Tw T* (\021\026\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\036\027\034 \035\036\021\026\035\034\027\024\f\021\017 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\016\b \023\030\024\n\036\032)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc -0.026 Tw T* (\027\024\f\021\017. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n \021\024\020\024 \032\036 \017\f\ \f\035\036\007\024\r\026\027\017\016 \024\021\030\t\r\t)8( )]TJ 0.17 Tw T* (\027\017\032\027\017\b \022\024\027\036\004\027\024\f\021\036\005 \027\026\ \002\035\033\007\026\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC [(64% \030\026\027\036\027\t\b,)7.9( )]TJ -0.014 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031)Tj /Span<>> BDC ( )Tj EMC (79% \002\t\035 \007\r\031\f\021\024\030\024\027\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (21%)Tj /Span<>> BDC ( )Tj EMC (\227 \024\007\027\024\f\021\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.24 Tw T* [(\030\024\027\027\017\005 \024\021\030\t\r \027\017\032\027\017\b \022\024\ \027\036\004\027\024\f\021\036\005. \215\024\r\030\036\032\007\036\027\017\ \016)8( )]TJ 0.163 Tw T* (\n\024\004\036\023\024\035\024\r\024\005 \f\017\f\021\036\n\t \r\t\016\r\ \035\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (72% \023\024\f\021\030\026\007\026\r)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.291 Tw T* [(\001\017\b, \023\024\r\030\036\032\007\036\027\017\036 \023\030\016\n\024\ \005 \022\017\001\022\017 \002\t\035\024 \r\t\016\r\035\036\027\024)8( )]TJ 0.153 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC [(28% \023\024\f\021\030\026\007\026\r\001\017\b )0.5([3]. \200)]TJ /Span<>> BDC ( )Tj EMC [(\022\030\031\023\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017)8.1( )]TJ -0.025 Tw T* [(\023\024\007 \030\031\022\024\r\024\007\f\021\r\024\n Gl)-16(asgo)-14(w S.C. \023\024\r\030\036\032\007\036\027\017\016 \023\030\016\n\024\005\ )8( )]TJ 0.113 Tw T* (\022\017\001\022\017 \002\t\035\017 \r\t\016\r\035\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (59% \004\036\035\024\r\036\022 \f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\036\027\017\016\n\017)8( )]TJ 0.029 Tw T* (\023\030\024\n\036\032\027\024\f\021\017, \031)Tj /Span<>> BDC ( )Tj EMC [(37% \002\t\035\017 \r\t\016\r\035\036\027\t \023\036\030\036\035\024\n\t\ \021\026\026,)8( )]TJ 0.053 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (48%)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\024\r\030\036\032\007\036\027\017\016 \027\026\030\031\032\027\ \t\b \023\024\035\024\r\t\b \024\030\020\026\027\024\r.)8( )]TJ 0.06 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n 76,1% \023\024\f\021\030\026\007\026\r\001\017\b \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\027\t\n\017 \030\026\027\036)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.002 Tw T* (\027\017\016\n\017 \023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\016\n\024\005 \022\017\001\022\017 \017\n\036\035\017 \030\026\027\ \036\027\017\016)7.9( )]TJ 0.317 Tw T* [(\n\017\027\027\024-\r\030\t\r\027\024\020\024 )0.5(\b\026\030\026\022\021\036\030\026, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 14.01 0 Td (23,9%)Tj /Span<>> BDC ( )Tj EMC 3.041 0 Td [(\227 )0.5(\023\031\035\036\r\t\036)8( )]TJ 0 Tw -17.052 -1.218 Td (\030\026\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([7].)Tj 0 Tc 0.309 Tw T* (\200 \n\017\030\027\024\036 \r\030\036\n\016 \021\030\026\r\n\t \023\030\ \024\n\036\032\027\024\f\021\017 \023\030\024\017\f\b\024\007\016\021 )Tj 0.188 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.895 0 Td [(\030\036\031\035\034\021\026\021\036 )0.6(\030\026\035\017\004\027\t\b )0.6(\002\t\021\024\r\t\b )0.5(\023\024\r\030\036\032\007\036\027\017\005, )0.6(\027\036)]TJ 0 Tw (-)Tj 0.175 Tw -0.895 -1.218 Td (\f\004\026\f\021\027\t\b \f\035\031\004\026\036\r, \007\024\030\024\032\027\ \024-\021\030\026\027\f\023\024\030\021\027\t\b \023\030\024\017\f\001\036\ )Tj 0 Tw (-)Tj 0.069 Tw T* (\f\021\r\017\005, \017\n\036\033\021 \022\024\035\024\021\024-\030\036\026\ \027\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\036 \024\020\027\036\f\021\030\036\035\034\027\t\005 )Tj 0.189 Tw T* (\b\026\030\026\022\021\036\030. \200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \f\035\031\004\026\036\r, \021\026\022\032\036 \022\026\ \022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \002\024\036\r\t\b )Tj 0.286 Tw T* [(\021\030\026\r\n\026\b, \023\030\024\017\f\b\024\007\017\021 )0.5(\023\024\r\030\036\032\007\036\027\017\036 \024\030\020\026\027\024\r \n\ \026\035\024\020\024 )]TJ 0.094 Tw T* (\021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\021\036\005 \021\026\026 [6,8,9,10]. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \024\002\001\017\030\027\t\036 )Tj 0.341 Tw T* (\030\026\027\t \023\030\024\n\036\032\027\024\f\021\017 \n\024\020\031\021\ \r\024\027\017\022\026\021\034 \023\024\f\035\036 \024\023\036\030\026\ )Tj 0 Tw (-)Tj 0.198 Tw T* [(\021\017\r\027\t\b )0.6(\r\n\036\001\026\021\036\035\034\f\021\r )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 10.933 0 Td [(\023\024\r\024\007\031 )0.5(\030\026\035\017\004\027\t\b )0.6(\017\027\235\036\022)]TJ 0 Tw (-)Tj 0.221 Tw -10.933 -1.218 Td [(\006\017\024\027\027\t\b \026\002\024\035\036\r\026\027\017\005 )0.5(\n\016\020\022\017\b \021\022\026\027\036\005 \023\030\024\n\036\032\027\ \024\f\021\017, )]TJ 0.146 Tw T* (\027\026\023\030\017\n\036\030, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \r\017\007\026\b \023\026\030\026\023\030\024\ \022\021\017\021\024\r \017\035\017 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 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S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-1-115-122)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 57.0504 695.3259 Tm [(\224\b\017\220\017\020\b\213\f\205\007\005 \026)11(\005\007)-10(\026\b\007\005 \013\f\213\f\t\b \223\005\216\b\f\t\026)11(\025\016 \205\022)-23.3(\210\025\f\016\240\024\b )]TJ 1.707 -1.105 Td [(\017\005\t\f\t\b\024\b \223\017\025\024\f\235\t\025\205)-10(\026\b $\025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\034\f\017\f)21(\002\025\217\025\016\022)-23.2(\207.\202.)]TJ 8.162 0 0 8.162 135.4408 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 140.0768 649.822 Tm [(, \036\t\t\b\216\f\016\022)-23.2(\030.\021.)]TJ 0 Tw 8.162 0 0 8.162 227.7517 654.484 Tm (2)Tj 0.023 Tw 14 0 0 14 232.3877 649.822 Tm [(, \037)31(\025)21(\001\013\025\016\022)-23.2(\202.\207.)]TJ 0 Tw 8.162 0 0 8.162 310.123 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 314.7589 649.822 Tm [(, \037)62(\220)31(\001\n\024\b\t\025\016\022)-23.2(\006)-31(.\200.)]TJ 0 Tw 8.162 0 0 8.162 413.3817 654.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 632.1527 Tm [(\201\031\214)21(\036)20(\230 \r\036 \253\033\025\205\205\b\255\205\007\b\255 \220\t\b\016\f\017\205\ \b\026)11.1(\f\026 \024\f\217\b\216\b\t\240\273 \204\b\t\001\217\017\005\016\005 \033\ \025\205\205\b\b $\220\013.\022)-23.3(\200\025\013\020)10(\025\017\220\007)10(\025\016\205\007\005, \217.\022)-23.3(4, \020)62(.\022)-23.3(\204\025\205\007\016\005, )]TJ -0.331 -1.2 Td [(1)125(2)46(7)63(006, \016\t. \026)11(\f\017)-31(. \020)62(.\022)-23.3(\204\220\t\b\216\b\223\005\013\n\t\240\255 \036\007\017\220\020 \032)30(\016\f\017\205\007)10(\025\255, \033\025\205\205\b$)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 608.1527 Tm [(\201\031\214)42(\230 \253\031)83(\013\005\016\t\240\255 \016\025\f\t\t\240\255 \007)-10(\013\b\t\b\213\f\205\007\b\255 \020)10(\025\205\223\b\026)11(\005\013\n \b\024\f\t\b \005\007\005\217\f\024\b\007\005 \202.\202.\022)-23.3(\214\220\017\217\f\t\007)10(\025\273 \204\b\t\b\205)-10(\026)11(\f\017\205)-10(\026\016\005 \025\210\025\017\025\t\240 )]TJ -0.331 -1.2 Td [(\033\025\205\205\b\255\205\007)10(\025\255 \201\f\217\f\017\005\216\b\b $\031)80(\025\205\223\b\026)11(\005\013\n\t\005 \223\013., \217.\022)-23.3(3, \020)62(.\022)-23.2(\204\025\205\007\016\005, 1)75(0509)80.1(4, \033\025\205\205\b$)]TJ /T1_1 1 Tf 9 0 0 9 90.7087 577.6488 Tm (\212\205\216\221: \f\033\034\036\016\024\035\022 \034\025\031\034\033 \027\ \022\035\016\033\037\035\023\033\032, \f\034\024\036\030\217\020\020\034\ \t \027\016\n\016\020\022\026 \025\034\016\036\034\t \035\033\037\036\b\032\ \f\033\034\b\016\003\020\034\024\035\022.)Tj 0.015 Tw 0 -1.111 TD (\240\213\200\205\255\235\213\216\223 \235)Tj /Span<>> BDC ( )Tj EMC (\240\205\200\211\203\223: \005\027\030 \037\020\037\027\022\031\037 \027\ \022\035\016\033\037\035\023\033\032 \036)Tj /Span<>> BDC ( )Tj EMC (\001\034\005\016 \020\037\f\022\024\037\020\022\030 \005\037\020\020\034\ \t \024\035\037\035\007\022 \025\032\027 \034\024\023\217\016\024\035\036\ \027\016\020 \f\034\022\024\021 )Tj 0.079 Tw T* [(\027\022\035\016\033\037\035\023\033\020\032\001 )0.5(\022\024\035\034\n\020\022\021\034\036 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\034\b\034\217\007\026 )0.5(\222\037\023\n\020\034\t )0.5(\220\027\016\021\035\033\034\020\020\034\t )0.5(\025\022\025\027\022\034\035\016\021\022 eLIBRARY.RU \022)]TJ /Span<>> BDC ( )Tj EMC 37.909 0 Td (\022\020\017\034\033\b\037\006\022\034\020\020\034\t )Tj 0.125 Tw -37.909 -1.111 Td [(\025\037\031\032 )0.6(PubMed.gov )0.6(\f\034)]TJ /Span<>> BDC ( )Tj EMC 8.799 0 Td [(\021\027\026\n\016\036\032\b )0.6(\024\027\034\036\037\b: )0.6(\253\033\037\020\016\020\022\030 )0.6(\f\033\034\b\016\003\020\034\024\035\022\273, )0.7(\253\033\037\020\016\020\022\030 )0.6(\f\033\030\b\034\t )0.6(\021\022\004\021\022\273, )0.5(\253\035\033\037\036\b\037 )0.6(\f\033\034)]TJ 0 Tw (-)Tj 0.017 Tw -8.799 -1.111 Td (\b\016\003\020\034\024\035\022\273, \253perineum injury\273, \253rectal \ injuries\273, \253perineum trauma\273. \201\033\016\036\037\027\022\033\023\ \016\035 \f\034\022\024\021 \005\037\020\020\032\001 \031\037)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\005\020\022\016 )Tj 0.023 Tw 0 -1.111 TD (10 \027\016\035.)Tj -0.004 Tw 0 -1.111 TD (\255\205\202\207\216\221\200\213\200\223: \036)Tj /Span<>> BDC ( )Tj EMC (\020\037\024\035\034\030\217\016\016 \036\033\016\b\030 \034\024\020\034\ \036\020\032\b \b\016\035\034\005\034\b \027\016\n\016\020\022\030 \025\034\ \016\036\032\001 \033\037\020\016\020\022\t \f\033\034\b\016\003\020\034\ \024\035\022 \024)Tj /Span<>> BDC ( )Tj EMC (\f\034\036\033\016\003\005\016\020\022\016\b )Tj 0.014 Tw 0 -1.111 TD (\036\020\016\025\033\026\004\022\020\020\034\t \n\037\024\035\022 \f\033\ \030\b\034\t \021\022\004\021\022 \030\036\027\030\016\035\024\030 \b\016\ \035\034\005 4D: \017\034\033\b\022\033\034\036\037\020\022\016 \f\033\034\ \021\024\022\b\037\027\007\020\034\t \024\035\034\b\032, \023\024\035\033\ \037\020\016\020\022\016 )Tj 0.142 Tw 0 -1.111 TD (\005\016\017\016\021\035\037 \f\033\030\b\034\t \021\022\004\021\022, \f\ \033\016\024\037\021\033\037\027\007\020\034\016 \005\033\016\020\022\033\ \034\036\037\020\022\016 \022)Tj /Span<>> BDC ( )Tj EMC (\005\022\024\035\037\027\007\020\034\016 \f\033\034\b\032\036\037\020\022\ \016 \f\033\030\b\034\t \021\022\004\021\022, \037)Tj /Span<>> BDC ( )Tj EMC (\035\037\021\003\016 )Tj 0.042 Tw 0 -1.111 TD [(\f\016\033\036\022\n\020\037\030 )0.5(\001\022\033\023\033\013\022\n\016\024\021\037\030 )0.5(\034\025\033\037\025\034\035\021\037 \033\037\020\032 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\034\024\027\016\005\023\026\217\022\b\022 )0.5(\024\037\020\037\006\022\030\b\022. \201\033\022)]TJ /Span<>> BDC ( )Tj EMC (\f\034\005\034\025\020\032\001 \035\033\037\036\b\037\001, \f\034\027\023\ \n\016\020\020\032\001 )Tj 0.125 Tw T* (\036)Tj /Span<>> BDC ( )Tj EMC (\b\022\033\020\034\016 \036\033\016\b\030, \037\036\035\034\033\032 \024\ \021\027\034\020\030\026\035\024\030 \021)Tj /Span<>> BDC ( )Tj EMC (\025\034\027\016\016 \005\022\017\017\016\033\016\020\006\022\033\034\036\ \037\020\020\034\b\023 \f\034\005\001\034\005\023 \021)Tj /Span<>> BDC ( )Tj EMC (\027\016\n\016\020\022\026, \021\034\035\034\033\034\016 \034\025\032\n\020\ \034 )Tj -0.013 Tw T* (\036)Tj /Span<>> BDC ( )Tj EMC (\035\034\t \022\027\022 \022\020\034\t \024\035\016\f\016\020\022 \034\035\ \027\022\n\037\016\035\024\030 \034\035 \021\034\020\006\016\f\006\022\022\ 4D. \002\035\034\022\035 \034\035\b\016\035\022\035\007, \n\035\034 \b\016\ \035\034\005\032 \022)Tj /Span<>> BDC ( )Tj EMC (\033\016\031\023\027\007\035\037\035\032 \027\016\n\016)Tj 0 Tw (-)Tj 0.079 Tw T* [(\020\022\030 \033\037\020 )0.5(\f\033\034\b\016\003\020\034\024\035\022, )0.5(\f\034\027\023\n\016\020\020\032\001 \036)]TJ /Span<>> BDC ( )Tj EMC 15.721 0 Td [(\b\022\033\020\034\016 \036\033\016\b\030, )0.5(\020\016\027\007\031\030 )0.5(\034\005\020\034\031\020\037\n\020\034 \f\033\034\016\006\022\033\034\036\ \037\035\007 \020\037)]TJ /Span<>> BDC ( )Tj EMC (\035\037\021\035\022\021\023 \027\016\n\016\020\022\030 )Tj 0.04 Tw -15.721 -1.111 Td (\025\034\016\036\032\001 \f\034\036\033\016\003\005\016\020\022\t \f\033\ \034\b\016\003\020\034\024\035\022. \204\035\034 \034\025\023\024\027\034\ \036\027\016\020\034 \b\034\033\017\034\027\034\013\022\n\016\024\021\022\ \b\022 \034\024\034\025\016\020\020\034\024\035\030\b\022 \033\037\020 \f\ \033\034\b\016\003\020\034\024\035\022, )Tj 0.023 Tw T* (\f\034\027\023\n\016\020\020\032\001 \036)Tj /Span<>> BDC ( )Tj EMC (\025\034\016\036\032\001 \023\024\027\034\036\022\030\001.)Tj 0.173 Tw T* (\202\213\r\216\225\210\205\222\235\205: \033\037\020\016\020\022\030 \f\033\ \034\b\016\003\020\034\024\035\022 \036\024\035\033\016\n\037\026\035\024\ \030 \f\033\022\b\016\033\020\034 \036)Tj /Span<>> BDC ( )Tj EMC (5,4% \024\027\023\n\037\016\036 \034\035 \034\025\217\016\t \025\034\016\ \036\034\t \035\033\037\036\b\032. )Tj 0.322 Tw T* (\222\037\022\025\034\027\016\016 \037\021\035\023\037\027\007\020\034\t \ \f\033\034\025\027\016\b\034\t \030\036\027\030\016\035\024\030 \024\034\ \n\016\035\037\020\020\037\030 \035\033\037\036\b\037 \036\020\016\025\033\ \026\004\022\020\020\034\t \n\037\024\035\022 \f\033\030\b\034\t \021\022\ \004\021\022. )Tj -0.03 Tw 0 -1.111 TD (\211\025\217\016\f\033\022\020\030\035\037\030 \035\037\021\035\022\021\037\ \001\022\033\023\033\013\022\n\016\024\021\034\013\034 \027\016\n\016\020\ \022\030 \025\034\016\036\032\001 \033\037\020\016\020\022\t \f\033\034\b\ \016\003\020\034\024\035\022 \024)Tj /Span<>> BDC ( )Tj EMC (\f\034\036\033\016\003\005\016\020\022\016\b \036\020\016\025\033\026\004\ \022\020)Tj 0 Tw (-)Tj 0.073 Tw 0 -1.111 TD (\020\034\t \n\037\024\035\022 \f\033\030\b\034\t \021\022\004\021\022 \024\ \027\034\003\022\027\037\024\007 \016\217 \036\034 \036\033\016\b\016\020\ \037 \036\034\t\020\032 \036\034 \215\007\016\035\020\037\b\016. \002)Tj /Span<>> BDC ( )Tj EMC (\035\016\001 \f\034\033 \035\037\021\035\022\021\037 \021\037\033\005\022\ \020\037\027\007\020\034 )Tj 0.146 Tw T* [(\020\016 )0.5(\022\031\b\016\020\022\027\037\024\007, )0.5(\037)]TJ /Span<>> BDC ( )Tj EMC [(\025\034\027\007\004\037\030 )0.5(\n\037\024\035\007 )0.5(\022\024\024\027\016\005\034\036\037\020\022\t, )0.6(\f\034\024\036\030\217\020\020\032\001 )0.5(\025\034\016\036\032\b \033\037\020\016\020\022\030\b \f\033\034\b\016\003\ \020\034\024\035\022, )0.5(\020\034\024\030\035, )0.5(\021\037\021 )]TJ 0.023 Tw T* (\f\033\037\036\022\027\034, \034\f\022\024\037\035\016\027\007\020\032\t\ \001\037\033\037\021\035\016\033 \022)Tj /Span<>> BDC ( )Tj EMC (\020\016 \005\037\026\035 \n\035\021\022\001 \033\016\021\034\b\016\020\ \005\037\006\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\027\016\n\016\020\022\026.)Tj /T1_2 1 Tf 0.01 Tc 0.132 Tw 8 0 0 8 42.5596 362.3796 Tm [(\037\033\255\200\030\025\202\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.137 Tw 8.607 0 Td ( \033\037\020\016\020\022\016 \f\033\034\b\016\003\020\034\024\035\022, \ VAC-\024\022\024\035\016\b\037, \036\020\016\025\033\026\004\022\020\020\ \037\030 \n\037\024\035\007 \f\033\030\b\034\t \021\022\004\021\022, \f\033\ \034\021\024\022\b\037\027\007\020\037\030 \024\035\034\b\037, \f\033\016\ \024\037\021\033\037\027\007\020\034\016 )Tj 0.023 Tw -8.612 -1.2 Td (\005\033\016\020\022\033\034\036\037\020\022\016, \005\022\024\035\037\027\ \007\020\034\016 \f\033\034\b\032\036\037\020\022\016)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.022 Tc -0.04 Tw -10.401 -2.617 Td [(\024)0.5(\033\023)5.5( \022)0.5(\032)0.5(\031\032)0.5(\027)0.5(\036\025)0.5(\021)0.5(\035\032)0.5(\023)0.5(:)]TJ /T1_3 1 Tf 0.012 Tc -0.035 Tw 8.945 0 Td [( \215\036)0.5(\030)0.5(\036\b)0.5(\024\007)0.5(\024\r)]TJ /Span<>> BDC 4.763 0 Td ( )Tj EMC [(\225.)0.5(\203)0.5(.,)0.5( \210\027)0.5(\027\017)0.5(\006)0.5(\036\r)]TJ /Span<>> BDC 5.958 0 Td ( )Tj EMC [(\230)0.5(.\213)0.5(.,)0.5( \025\024)0.5()0.5(\035\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\203)0.5(.\225)0.5(.,)0.5( \025)0.5(\031)0.5(\034\n)0.5(\017\027)0.5(\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\202)0.5(.\212)0.5(. \216)0.5(\017\030)0.5(\031)0.5(\030\020)0.5(\017\004)0.5(\036\f)0.5(\022\026)0.5(\016 )0.5(\021\026)0.5(\022\021)0.5(\017\022)0.5(\026 \035)0.5(\036\004)0.5(\036)0.5(\027\017)0.5(\016 )0.5(\023\026)0.5(\006\017)0.5(\036\027)0.5(\021\024)0.5(\r \f)]TJ /Span<>> BDC 33.091 0 Td ( )Tj EMC [(\002\024)0.5(\036)0.5(\r\t)0.5(\n\017)12( )]TJ 0.001 Tc -52.762 -1.2 Td [(\030\026)0.5(\027\036)0.5(\027\017)0.5(\016\n)0.5(\017 \023\030)0.5(\024\n)0.5(\036\032\027)0.5(\024\f)0.5(\021\017)0.5( $\024\002)0.5(\024)0.5(\030 \035\017)0.5(\021\036)0.5(\030\026)0.5(\021\031\030)0.5(\t$)0.5(. )]TJ /T1_1 1 Tf -0.001 Tw [(\r\034)0.5(\027\034)0.5(\f\033)0.5(\034\021)0.5(\035\034)0.5(\027\034)0.5(\013\022\030)0.5(.)]TJ /T1_3 1 Tf -0.035 Tw [( 2)0.5(025)0.5(; \021)0.5(.)]TJ /Span<>> BDC ( )Tj EMC [(24)0.5(, \223)]TJ /Span<>> BDC 32.676 0 Td ( )Tj EMC [(1,)0.5( \f.)]TJ /Span<>> BDC ( )Tj EMC [(1)0.5(15)0.5(\22612)0.5(2. h)0.5(tt)0.5(ps)0.5(://)0.5(do)0.5(i.o)0.5(rg)0.5(/10)0.5(.3)0.5(387)0.5(8/)0.5(207)0.5(3-)0.5(755)0.5(6-)0.5(202)0.5(5-)]TJ 0.023 Tc -0.023 Tw -32.676 -1.2 Td (24-1-115-122)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 84.6958 265.0332 Tm [(Sur)31(ger)-30.9(y of militar)-30.9(y injuries of th)11(e perineum $r)31(e)11(vie)11(w$)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 240.5293 Tm [(Ser)31(gey\022)-23.3(N.\022)-23.2(P)10(er)31(ekh)11(odov)]TJ 8.162 0 0 8.162 168.4287 245.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 173.0647 240.5293 Tm [(, Igor\022)-23.2(E.\022)-23.3(Onnitse)11(v)]TJ 0 Tw 8.162 0 0 8.162 271.0333 245.1913 Tm (2)Tj 0.023 Tw 14 0 0 14 275.6692 240.5293 Tm [(, Nik)11(olay\022)-23.2(S.\022)-23.3(K)41(o)15(zlov)]TJ 0 Tw 8.162 0 0 8.162 384.3062 245.1913 Tm (1)Tj 14 0 0 14 388.9421 240.5293 Tm (, )Tj -24.744 -1.143 Td [(Alek)11(sey\022)-23.2(D.\022)-23.3(K)31(u)21(zminov)]TJ 8.162 0 0 8.162 160.2384 229.1913 Tm (1)Tj 5.83 0 0 5.83 42.5197 210.19 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 206.86 Tm [(Russian Univ)12(er)20(sit)-19.9(y of\022)-23.3(Medicine $Dolgor)10(uk)11(ov)10(skay)21.1(a\022)-23.3(st., 4, Moscow)22.1(, 1)125(2)46(7)63(006, Russia$)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 198.19 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 194.86 Tm [(N.N.\022)-23.3(Bur)31(denk)11(o Main Militar)-31(y Clinical Hospital $Hospitalnay)21.1(a s)11(q., 3, Moscow)22(, 1)75(0509)80(4, Russia$)]TJ /T1_1 1 Tf 9 0 0 9 90.7087 176.3561 Tm [(AIM: to analyze literature on per)-36.9(ineal militar)-42.9(y injur)-36.9(ies.)]TJ 0.118 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a search of sources w)13(as car)-15.9(r)-37(ied out using eLIBRARY)68(.R)27(U and the PubMed.gov using the )]TJ 0.03 Tw T* [(k)17(eyw)12(ords: )0.5(\242per)-37(ineal )0.5(w)12(ounds\243, )0.5(\242rectal )0.5(w)12(ounds\243, )0.5(\242per)-37(ineal )0.5(trauma\243, )0.5(\242per)-37(ineum injur)-43(y\243, \242rectal injur)-36.9(ies\243, \242per)-36.9(ineum )]TJ 0.023 Tw T* (trauma\243 for the last 10 years.)Tj -0.015 Tw T* [(RESUL)30(T)-10(S: recently)42.1(, the main method for militar)-42.9(y injur)-36.9(ies of the per)-37(ineum with d)26(amag)12(e to the e)-15(xtraper)-37(itoneal par)-40(t of )]TJ 0.019 Tw 0 -1.111 TD [(the rectum is the 4D method: div)13(er)-40(ting stoma, elimination of the rectal defect, p)46(resacral drainag)11.9(e and distal lav)16(ag)12(e )]TJ 0.112 Tw 0 -1.111 TD [(of )0.5(the )0.5(rectum, )0.5(as )0.5(w)12(ell )0.5(as p)46(r)-36.9(imar)-43(y )0.5(surgical )0.5(treatment )0.6(of the )0.5(w)12(ound )0.5(with )0.5(subseq)14(uent sanitation. )0.5(F)12(or )0.5(such injur)-37(ies )]TJ 0.009 Tw T* [(receiv)13(ed in peacetime, the authors are inclined to a more dif)-39.9(ferentiated app)46.1(roach, which usually dif)-40(fers from the 4D )]TJ -0.026 Tw T* [(concep)13(t. )0.6(It )0.6(is )0.5(w)12(or)-39.9(th )0.5(no)13(ting )0.6(that )0.6(the )0.5(methods )0.6(and )0.6(results )0.6(of )0.6(treating )0.6(per)-37(ineal )0.5(w)12(ounds )0.5(receiv)13(ed )0.5(in )0.6(peacetime )0.5(canno)13(t )0.6(be )]TJ -0.003 Tw T* [(unambiguously p)46(rojected onto the treating of militar)-43(y injur)-37(ies. This is due to the mor)-17.9(phological features of per)-37(ineal )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 586.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 577.226 Tm (\027\030\203\255\204\030)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 184.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 175.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 504.6022 56.0378 Tm (115)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 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-20.271 -1.187 Td [(G)20.2(r)-31.7(oup. V)30.3(ed)-15.7(ol)-30.7(izumab ver)-9.7(sus ad)42.3(al)-30.7(imumab for moder)-32.7(a)15.2(te-t)17.2(o-sever)-23.8(e)8( )]TJ 0 Tc 0.023 Tw T* [(ul)16(cer)-33(a)15.1(t)-32(i)-16(ve col)-31(i)-24(t)-31.9(is. )]TJ /T1_1 1 Tf [(N Eng)13(l J Med)]TJ /T1_0 1 Tf (. 2019;381:1215\2261226.)Tj 0.037 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)10(ouill)30(on)]TJ /Span<>> BDC ( )Tj EMC (L, Baumann)Tj /Span<>> BDC ( )Tj EMC [(C, R)11(ousseau)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-23.9(ea)15(tment per)-9.9(sistence )]TJ 0.051 Tw -1.796 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC [(infl)-31(iximab ver)-10(sus ad)42(al)-31(imumab in ul)16(cer)-32.9(a)14.9(t)-31.9(i)-16(ve col)-31(i)-24(t)-32(is: a)]TJ /Span<>> BDC ( )Tj EMC (16-year sin)Tj 0 Tw (-)Tj -0.026 Tw T* [(gle-center e)-17.9(xper)-37(ience. )]TJ /T1_1 1 Tf [(Inf)-22(lamm Bow)12.1(el Dis.)]TJ /T1_0 1 Tf [( 2019;25:945\226954. F)9.9(r)-32.9(ance.)]TJ 0.106 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)-17(cal)35(uso)]TJ /Span<>> BDC ( )Tj EMC 4.016 0 Td [(FS, )0.5(V)30(ent)-32(imigl)-30.9(ia)]TJ /Span<>> BDC ( )Tj EMC [(M, )0.5(F)10(r)-36.9(ies)]TJ /Span<>> BDC ( )Tj EMC 9.834 0 Td [(W, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.397 0 Td [(al. )0.5(S)-16(ic)-24(il)-30.9(ian )0.5(Ne)-12(t)-32(w)-14(or)-24(k )0.5(for )]TJ 0.071 Tw -18.043 -1.187 Td [(Infl)-16(amma)15.1(t)17(or)-24(y Bo)-14(wel Disease $SN-IBD$. A)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(opensi)-24(t)-9.9(y scor)-23.9(e weighted )]TJ -0.001 Tw T* [(com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC 5.898 0 Td [(V)30(ed)-16(ol)-31(izumab, )0.5(A)15(d)42(al)-31(imumab, )0.5(and Gol)-31(imumab in p)32(a)15(t)-31.9(ients )]TJ 0.023 Tw -5.898 -1.187 Td [(wi)-24(t)-12.9(h ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf [(Dig Liv)13(er Dis.)]TJ /T1_0 1 Tf ( 2020;52:1461\2261466.)Tj 0.121 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)47(hor)-30(l)35(und)]TJ /Span<>> BDC ( )Tj EMC [(K, Dr)-22(uy)-16(ts)]TJ /Span<>> BDC ( )Tj EMC (E, Mills)Tj /Span<>> BDC ( )Tj EMC 11.144 0 Td [(EJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)15(d)42(al)-31(imumab ver)-9.9(sus infl)-31(ix)]TJ 0 Tw (-)Tj 0.139 Tw -12.94 -1.187 Td [(imab for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(moder)-33(a)15(te t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(sever)-23.9(e ul)16(cer)-32.9(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is in )]TJ 0.003 Tw T* [(adul)56(t p)32(a)15(t)-32(ients na\357ve t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(i-TNF t)-12.9(her)-33(apy: An)]TJ /Span<>> BDC ( )Tj EMC [(indir)-24(ec)-16(t tr)-24(ea)15(tment com)]TJ 0 Tw (-)Tj 0.023 Tw T* [(p)32(ar)-37(ison me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_1 1 Tf (J Crohn\245s Colitis.)Tj /T1_0 1 Tf ( 2014;8:571\226581.)Tj 0.15 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(estens)]TJ /Span<>> BDC ( )Tj EMC [(C, v)-14.9(an Oijen)]TJ /Span<>> BDC ( )Tj EMC (MG, Mulder)Tj /Span<>> BDC ( )Tj EMC [(CL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dutch Ini)-23.9(t)-32(ia)15(t)-32(i)-16(ve on )]TJ 0.292 Tw -1.796 -1.187 Td [(Cr)-32(ohn and Col)-31(i)-24(t)-32(is [ICC]. A)15(d)42(al)-31(imumab and infl)-31(iximab ar)-24(e equall)35.1(y )]TJ 0.063 Tw T* [(ef)-56(fec)-16(t)-31.9(i)-16(ve for Cr)-32(ohn\241s disease in p)32(a)15(t)-32(ients no)17(t p)25(r)-24(ev)-16(iousl)35.1(y tr)-24(ea)15(ted wi)-24(t)-13(h )]TJ 0.349 Tw T* [(ant)-32(i-tumor necr)-31.9(osis f)16(a)-17(c)-16(t)17(or-\256 a)-17(gents. )]TJ /T1_1 1 Tf (Clin Gastroenterol Hepatol)Tj /T1_0 1 Tf 0 Tw (. )Tj T* (2013;11:826\226831.)Tj 0.182 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Nar)-22(ul)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(N, K)-16(ainz)]TJ /Span<>> BDC ( )Tj EMC [(S, P)30(e)-12(tr)-37(i)-23.9(tsch)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(ef)-56(f)-28(ica)-17(cy and safe)-11.9(t)-10(y )]TJ 0.07 Tw -1.796 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC [(ei)-24(t)-13(her infl)-30.9(iximab or ad)42(al)-31(imumab in 362 p)32.1(a)14.9(t)-31.9(ients wi)-24(t)-13(h ant)-32(i-TNF-\256 )]TJ 0.023 Tw T* [(na\357ve Cr)-31.9(ohn\241s disease. )]TJ /T1_1 1 Tf [(Aliment Phar)-14(macol Ther)]TJ /T1_0 1 Tf (. 2016;44:170\226180.)Tj 0.001 Tc 0.35 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.801 0 Td [(Ma)-17.1(cal)34.9(uso)]TJ /Span<>> BDC ( )Tj EMC [(FS, F)9.9(r)-37.1(ies)]TJ /Span<>> BDC ( )Tj EMC [(W, P)34.9(r)-37.1(i)-16.1(v)-16.1(i)-24.1(ter)-33.1(a)]TJ /Span<>> BDC ( )Tj EMC [(A)15.9(C, )0.5(e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC 17.202 0 Td [(al. S)-16.1(ic)-24.1(il)-31.1(ian Ne)-12.1(t)-32.1(w)-14.2(or)-24.1(k)1( )]TJ 0 Tc 0.335 Tw -19.003 -1.187 Td [(for Infl)-15.9(amma)15(t)17(or)-24(y Bo)-13.9(wel Diseases [SN-IBD]. A)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(opensi)-23.9(t)-10(y scor)-24(e-)]TJ 0.013 Tw T* [(ma)15(tched com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(infl)-31(iximab and ad)42(al)-31(imumab in tumour necr)-32(o)]TJ 0 Tw (-)Tj 0.274 Tw T* [(sis f)16.1(a)-17(c)-16(t)17(or-\256 inhibi)-23.9(t)17(or-na\357ve and non-na\357ve p)32(a)15(t)-32(ients wi)-24(t)-12.9(h Cr)-32(ohn\241s )]TJ 0.167 Tw T* [(disease: r)-24(eal-l)-30.9(ife d)42(a)15(t)15(a fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(S)-16(ic)-23.9(il)-31(ian Ne)-12(t)-32(w)-14(or)-24(k for Infl)-16(amma)15(t)17(or)-23.9(y )]TJ 0.023 Tw T* [(Bo)-14(wel Disease. )]TJ /T1_1 1 Tf (J Crohns Colitis. )Tj /T1_0 1 Tf 0 Tw (2019;13:209\226217.)Tj 0.106 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)-17(cal)35(uso)]TJ /Span<>> BDC ( )Tj EMC 4.016 0 Td [(FS, )0.5(V)30(ent)-32(imigl)-30.9(ia)]TJ /Span<>> BDC ( )Tj EMC [(M, )0.5(F)10(r)-36.9(ies)]TJ /Span<>> BDC ( )Tj EMC 9.834 0 Td [(W, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.397 0 Td [(al. )0.5(S)-16(ic)-24(il)-30.9(ian )0.5(Ne)-12(t)-32(w)-14(or)-24(k )0.5(for )]TJ 0.071 Tw -18.043 -1.187 Td [(Infl)-15.9(amma)15(t)17(or)-24(y Bo)-14(wel Disease $SN-IBD$. A)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(opensi)-24(t)-9.9(y scor)-23.9(e weighted )]TJ 0.182 Tw T* [(com)10(p)32(ar)-37(ison )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(ved)-15.9(ol)-31(izumab )0.5(and )0.5(ad)42(al)-31(imumab )0.6(in )0.5(Cr)-32(ohn\241s )0.5(disease. )]TJ /T1_1 1 Tf 0 Tw 27.2 0 Td (J )Tj 0.023 Tw -27.2 -1.187 Td (Gastroenterol Hepatol)Tj /T1_0 1 Tf (. 2021;36:105\226111.)Tj -0.039 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Bohm)Tj /Span<>> BDC ( )Tj EMC (M, Xu)Tj /Span<>> BDC ( )Tj EMC (R, Zhang)Tj /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. VICT)20(OR)-14(Y Coll)-15.9(abor)-33(a)15(t)-32(ion. Com)10(p)32(ar)-33(a)15(t)-32(i)-15.9(ve )]TJ 0.126 Tw -1.796 -1.187 Td [(safe)-12(t)-10(y and ef)-56(fec)-15.9(t)-32(i)-16(veness of)]TJ /Span<>> BDC ( )Tj EMC [(ved)-16(ol)-30.9(izumab t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(tumour necr)-32(osis f)16(a)-17(c)-16(t)17.1(or )]TJ 0.296 Tw T* [(ant)15(a)-17(gonist t)-13(her)-32.9(apy for Cr)-32(ohn\241s disease. )]TJ /T1_1 1 Tf [(Aliment Phar)-14(macol Ther.)]TJ /T1_0 1 Tf 0 Tw ( )Tj T* (2020;52:669\226681.)Tj 0.267 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC [(Oster)-15.9(man)]TJ /Span<>> BDC ( )Tj EMC [(MT, Ha)15(ynes)]TJ /Span<>> BDC ( )Tj EMC [(K, Del)-39.9(zell)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve ef)-55.9(fec)]TJ 0 Tw (-)Tj 0.3 Tw T* [(t)-32(i)-16(veness of)]TJ /Span<>> BDC ( )Tj EMC [(infl)-30.9(iximab and ad)42(al)-31(imumab for Cr)-32(ohn\241s disease. )]TJ /T1_1 1 Tf 0 Tw (Clin )Tj 0.023 Tw T* (Gastroenterol Hepatol)Tj /T1_0 1 Tf (. 2014;12:811\226817.e3.)Tj 0.076 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jung)Tj /Span<>> BDC ( )Tj EMC (YS, Han)Tj /Span<>> BDC ( )Tj EMC [(M, P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biol)30(o)-16(gic use p)32(a)15(t)-30(ter)-15(ns and p)25(r)-24(edic)]TJ 0 Tw (-)Tj 0.067 Tw -1.796 -1.187 Td [(t)17(or)-10(s for non-per)-9.9(sistence and swi)-23.9(tching of)]TJ /Span<>> BDC ( )Tj EMC [(biol)30(o)-16(gics in p)32(a)15(t)-32(ients wi)-24(t)-13(h )]TJ 0.115 Tw T* [(infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease: a)]TJ /Span<>> BDC ( )Tj EMC [(na)15(t)-32(ionwide popul)-16(a)15(t)-31.9(ion-based stud)17(y. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Dig)12(estiv)13(e diseases and sciences.)]TJ /T1_0 1 Tf [( 2020 Ma)15(y;65$5$:1436\22644.)]TJ 0.048 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ee)]TJ /Span<>> BDC ( )Tj EMC 1.623 0 Td [(YI, )0.6(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC 3.321 0 Td [(Y, )0.5(P)40(ar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC 2.947 0 Td [(SJ, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.491 0 Td [(al. )0.5(Com)10.1(p)32(ar)-37(ison )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.324 0 Td [(l)30(ong-ter)-15.9(m )0.5(outcomes )]TJ -0.027 Tw -19.502 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC [(infl)-30.9(iximab ver)-10(sus )0.5(ad)42(al)-31(imumab tr)-23.9(ea)15(tment in biol)30(o)-16(gic-na\357ve )0.5(p)32(a)15(t)-32(ients )]TJ 0.023 Tw T* [(wi)-24(t)-12.9(h ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-24(t)-32(is. )]TJ /T1_1 1 Tf [(Gut Liv)13(er.)]TJ /T1_0 1 Tf ( 2021;15:232\226242.)Tj -0.051 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Br)-24(essler)]TJ /Span<>> BDC ( )Tj EMC [(B, Y)50(ar)-22(ur)]TJ /Span<>> BDC ( )Tj EMC [(A, K)25(opyl)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(U, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-30.9(inical Ef)-56(fec)-16(t)-31.9(i)-16(veness of)]TJ /Span<>> BDC ( )Tj EMC [(F)-19(ir)-10(st-)]TJ 0.225 Tw -1.796 -1.187 Td [(L)-32(ine Ant)-31.9(i-TNF T)47(her)-33(apies and Second-L)-31.9(ine Ant)-32(i-TNF T)47(her)-33(apy P)10(ost-)]TJ 0.125 Tw T* [(V)30(ed)-16(ol)-31(izumab Discont)-32(inua)15(t)-31.9(ion in P)40(a)15(t)-32(ients wi)-24(t)-12.9(h Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve Col)-31(i)-23.9(t)-32(is or )]TJ 0.02 Tw T* [(Cr)-32(ohn\241s Disease. )]TJ /T1_1 1 Tf [(U)22(nited European Gastroenterol)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj /T1_0 1 Tf 0 Tw (2019;7$8\(Suppl.$\). )Tj 0.023 Tw T* [(P)10(oster P1091)]TJ 0.019 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Huang1 Z, Ba)Tj /Span<>> BDC ( )Tj EMC [(Y, K)-16(amble1 P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sequenc)-23.9(ing of)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(i-TNF a)-17(gents )]TJ 0.233 Tw -1.796 -1.187 Td [(and )0.5(gut-selec)-16(t)-32(i)-15.9(ve ant)-31.9(i-l)35(ym)10(pho)-16(cy)-16(te )0.5(tr)-33(af)-55.9(f)-28(ick)-16(ing )0.5($GSAL)75(T$ )0.5(t)-13(her)-33(apy )0.5(in )]TJ -0.048 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(Cr)-32(ohn\241s disease $CD$. )]TJ /T1_1 1 Tf (J Crohn\245s Colitis.)Tj /T1_0 1 Tf ( 2021;15$Suppl )Tj 0 Tw T* (1$:S302\2263.P267)Tj 0.006 Tc 0.349 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.82 0 Td (Miller)Tj /Span<>> BDC ( )Tj EMC [(C, K)20(w)-13.9(ok)]TJ /Span<>> BDC ( )Tj EMC [(H, Har)-23.9(r)-31.9(o)-14(w)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10.1(p)32(ar)-32.9(a)15.1(t)-32(i)-15.9(ve ef)-55.9(fec)-15.9(t)-31.9(i)-15.9(ve)]TJ 0 Tc 0 Tw (-)Tj 0.188 Tw -1.82 -1.187 Td (ness of)Tj /Span<>> BDC ( )Tj EMC 3.42 0 Td (a)Tj /Span<>> BDC ( )Tj EMC [(second-l)-30.9(ine biol)30(o)-16(gic )0.5(in p)32(a)15(t)-32(ients )0.5(wi)-24(t)-13(h )0.5(ul)16(cer)-33(a)15(t)-32(i)-16(ve )0.5(col)-31(i)-24(t)-32(is: )]TJ 0.004 Tc 0.349 Tw -3.42 -1.187 Td [(ved)-15.8(ol)-30.7(izumab foll)30.3(o)-13.8(wed b)12.2(y an)]TJ /Span<>> BDC ( )Tj EMC [(ant)-31.8(i-TNF ver)-9.7(sus ant)-31.8(i-TNF foll)30.2(o)-13.8(wed)4( )]TJ 0 Tc 0.331 Tw T* [(b)12(y ved)-16(ol)-30.9(izumab. )]TJ /T1_1 1 Tf [(F)27(rontline Gastroenterol.)]TJ /T1_0 1 Tf ( 2022 Jan 7;13$5$:392\226)Tj 0.19 Tw T* [(401. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1136/fl)16(gastr)-32(o-2021-101906)]TJ 0 0 0 1 k /GS1 gs 0.19 Tw [( PMID: )0.5(36051959; PMCID: )]TJ 0 Tw T* (PMC9380760.)Tj 0.131 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Sands)Tj /Span<>> BDC ( )Tj EMC [(BE, Ir)-32(v)-16(ing)]TJ /Span<>> BDC ( )Tj EMC [(PM, Ho)-16(ops)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 775d Ustek)-15.9(inumab ver)-10(sus )]TJ 0.186 Tw -1.796 -1.187 Td [(ad)42(al)-31(imumab for induc)-15.9(t)-32(ion and maintenance t)-13(her)-33(apy in moder)-33(a)15(te-)]TJ 0.037 Tw T* [(t)17(o-sever)-23.9(e Cr)-32(ohn\241s disease: t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(SEA)36.1(VUE stud)17(y. )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology)Tj /T1_0 1 Tf 0.037 Tw (. 2021 )Tj 0.023 Tw T* [(A)10(ug 1;161$2$:e30\2261.)]TJ 0.32 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(opyl)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(U, Ben-Hor)-37(in)]TJ /Span<>> BDC ( )Tj EMC [(S, Zmor)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ant)-31.9(i-tumor necr)-31.9(o)]TJ 0 Tw (-)Tj 0.007 Tc 0.349 Tw 27.259 79.563 Td [(sis f)16.3(a)-16.7(c)-15.7(t)17.3(or and post)17.3(oper)-32.7(a)15.3(t)-31.8(i)-15.6(ve com)10.3(pl)-30.7(ica)15.3(t)-31.7(ions in Cr)-31.7(ohn\241s disease:)7( )]TJ 0.002 Tc 0.35 Tw T* [(sy)-13.3(stema)14.6(t)-32.3(ic r)-24.3(ev)-16.4(iew and me)-12.4(t)14.7(a-anal)34.7(y)-13.4(sis. )]TJ /T1_1 1 Tf [(Inf)-22.4(lamm Bow)11.7(el Dis)]TJ /T1_0 1 Tf [(. 2012)2( )]TJ 0 Tc 0.239 Tw T* [(Dec;18$12$:2404\22613. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/ibd.22954)Tj 0 0 0 1 k /GS1 gs 0.239 Tw ( Epub 2012 Mar 29. )Tj 0.023 Tw T* (PMID: 22467533.)Tj 0.141 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)20(av)-15(ale)]TJ /Span<>> BDC ( )Tj EMC [(A, Onal)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(S, Cap)25(r)-37(iol)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(F, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. It)15(al)-31(ian G)20(r)-31.9(oup for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(stud)17.1(y )]TJ 0.007 Tc 0.35 Tw -1.796 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.419 0 Td [(Infl)-16.1(amma)14.9(t)17(or)-24(y Bo)-14.1(wel )0.5(Disease $IG-IBD$. )0.5(Com)10(p)31.9(ar)-33.1(a)15(t)-32.1(i)-16(ve )0.5(ef)-56(f)-28(ica)-17.1(cy)7( )]TJ 0 Tc 0.046 Tw -1.419 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC [(ved)-16(ol)-30.9(izumab and ad)42(al)-31(imumab in ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-24(t)-32(is p)32(a)15(t)-32(ients p)25(r)-24(ev)-16(i)]TJ 0 Tw (-)Tj 0.214 Tw T* [(ousl)35(y tr)-23.9(ea)14.9(ted wi)-24(t)-13(h infl)-31(iximab. )]TJ /T1_1 1 Tf [(Inf)-22(lamm Bow)12(el Dis.)]TJ /T1_0 1 Tf ( 2019;25:1805\226)Tj 0 Tw T* (1812.)Tj 0.074 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Rundquist)Tj /Span<>> BDC ( )Tj EMC 4.389 0 Td [(S, )0.5(Sa)-17(chs)]TJ /Span<>> BDC ( )Tj EMC 3.549 0 Td [(MC, )0.5(Er)-37(ik)-9.9(sson)]TJ /Span<>> BDC ( )Tj EMC 5.3 0 Td [(C, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.096 0 Td [(al. )0.5(S)-10(WIBREG )0.6(S)15(tud)17(y )0.5(G)20(r)-32(oup. )]TJ 0.251 Tw -17.13 -1.187 Td [(Dr)-22(ug sur)-32(v)-16(i)-15.9(v)-15(al of)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(i-TNF a)-17(gents com)10(p)32(ar)-24(ed wi)-24(t)-12.9(h ved)-16(ol)-30.9(izumab as )]TJ 0.153 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(second-l)-30.9(ine biol)30(o)-16(gical tr)-23.9(ea)15(tment in infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel )0.5(disease: )]TJ 0.101 Tw T* [(r)-24(esul)56.1(ts fr)-32(om na)14.9(t)-31.9(ionwide Swedish r)-24(egister)-10(s. )]TJ /T1_1 1 Tf [(Aliment Phar)-13.9(macol Ther.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.209 Tw T* [(2021 F)9.9(eb;53$4$:471\226483. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/apt.16193)Tj 0 0 0 1 k /GS1 gs 0.209 Tw ( Epub 2020 Dec )Tj 0.023 Tw T* (19. PMID: 33340426; PMCID: PMC7898922. \225. 471-477.)Tj -0.003 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ir)-23.9(hus)]TJ /Span<>> BDC ( )Tj EMC [(S)17(S, L)-32(ie H\370i)-16(v)-16(ik)]TJ /Span<>> BDC ( )Tj EMC [(M, M)-24(oum)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P191 Dr)-21.9(ug sur)-31.9(v)-16(i)-16(v)-15(al of)]TJ /Span<>> BDC ( )Tj EMC (bio)Tj 0 Tw (-)Tj 0.014 Tw -1.796 -1.187 Td [(l)30(o)-16(gics in Cr)-32(ohn\241s disease tr)-24(ea)15(tment in N)-14(or)-37.9(w)-12(a)15(y. )]TJ /T1_1 1 Tf [(Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (Crohn\245s and )Tj 0 Tw T* (Colitis.)Tj /T1_0 1 Tf 0.103 Tw [( Mar)-32(ch 2019;13$Suppl.1$:S185\226S186, d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ecco-jcc/)Tj T* (jjy222.315.)Tj 0 0 0 1 k /GS1 gs -0.025 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Biemans)Tj /Span<>> BDC ( )Tj EMC [(VBC, v)-15(an der W)20(oude)]TJ /Span<>> BDC ( )Tj EMC [(CJ, Dijk)-10(str)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dutch Ini)-24(t)-32(ia)15(t)-32(i)-16(ve )]TJ 0.044 Tw -1.796 -1.187 Td [(on Cr)-32(ohn and Col)-31(i)-24(t)-32(is $ICC$. Ustek)-15.9(inumab is asso)-16(c)-24(ia)15.1(ted wi)-23.9(t)-13(h super)-37(ior )]TJ 0.026 Tw T* [(ef)-56(fec)-16(t)-31.9(i)-16(veness outcomes )0.5(com)10(p)32(ar)-24(ed t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(ved)-15.9(ol)-31(izumab in )0.5(Cr)-32(ohn\241s disease )]TJ 0.039 Tw T* [(p)32(a)15(t)-32(ients wi)-24(t)-13(h p)25(r)-37(ior f)16(ail)35(ur)-24(e t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(i-TNF tr)-24(ea)15(tment. )]TJ /T1_1 1 Tf [(Aliment Phar)-13.9(macol )]TJ 0 Tw T* (Ther)Tj /T1_0 1 Tf 0.023 Tw (. 2020;52:123\226134.)Tj 0.015 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)12(r)-36.9(ic)]TJ /Span<>> BDC ( )Tj EMC [(H, Amio)17.1(t)]TJ /Span<>> BDC ( )Tj EMC [(A, Kir)-32(chgesner)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(ef)-56(fec)-15.9(t)-32(i)-16(veness of)]TJ /Span<>> BDC ( )Tj EMC [(ei)-24(t)-12.9(her )]TJ 0.169 Tw -1.796 -1.187 Td [(ustek)-16(inumab or ved)-16(ol)-31(izumab in 239 p)32(a)15(t)-32(ients wi)-24(t)-13(h Cr)-32(ohn\241s disease )]TJ 0.149 Tw T* [(r)-24(efr)-32.9(a)-17(c)-16(t)17(or)-24(y t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(ant)-32(i-tumour necr)-32(osis f)16(a)-16.9(c)-16(t)17(or. )]TJ /T1_1 1 Tf [(Aliment Phar)-13.9(macol Ther)]TJ /T1_0 1 Tf 0 Tw (. )Tj T* (2020;51:948\226957.)Tj 0.004 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)45(o)-14(wnsend)]TJ /Span<>> BDC ( )Tj EMC 4.191 0 Td [(T, R)-10(a)-23.9(zansk)-17(ai)-24(te)]TJ /Span<>> BDC ( )Tj EMC [(V, )0.5(Dodd)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 11.148 0 Td [(al. Com)10.1(p)31.9(ar)-32.9(a)15(t)-32(i)-16(ve ef)-55.9(fec)-16(t)-32(i)-16(ve)]TJ 0 Tw (-)Tj 0.089 Tw -17.135 -1.187 Td (ness of)Tj /Span<>> BDC ( )Tj EMC [(ustek)-15.9(inumab or ved)-16(ol)-31(izumab )0.5(af)-28(ter one year in 130 p)32(a)15(t)-32(ients )]TJ 0.203 Tw T* [(wi)-24(t)-12.9(h ant)-32(i-TNF-r)-23.9(efr)-33(a)-17(c)-16(t)17(or)-23.9(y Cr)-32(ohn\241s disease. )]TJ /T1_1 1 Tf [(Aliment Phar)-14(macol Ther)]TJ /T1_0 1 Tf 0 Tw (. )Tj T* (2020;52:1341\2261352.)Tj 0.25 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(o)]TJ /Span<>> BDC ( )Tj EMC 1.476 0 Td [(Y, )0.5(P)40(ar)-33(amso)17(t)-12.9(hy)]TJ /Span<>> BDC ( )Tj EMC 6.298 0 Td [(S, )0.5(Y)50(au)]TJ /Span<>> BDC ( )Tj EMC 3.025 0 Td [(Y, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.462 0 Td [(al. )0.5(Super)-37(ior )0.6(tr)-24(ea)15(tment )0.5(per)-10(sis)]TJ 0 Tw (-)Tj 0.306 Tw -15.056 -1.187 Td [(tence wi)-23.9(t)-13(h ustek)-16(inumab in Cr)-32(ohn\241s disease and ved)-16(ol)-31(izumab in )]TJ 0.244 Tw T* [(ul)16(cer)-33(a)15.1(t)-32(i)-16(ve )0.5(col)-30.9(i)-24(t)-32(is )0.6(com)10(p)32(ar)-24(ed )0.5(wi)-23.9(t)-13(h )0.5(ant)-32(i-TNF )0.6(biol)30(o)-16(gical )0.6(a)-17(gents: )0.6(r)-24(eal )]TJ 0.228 Tw T* [(w)-14(or)-30(ld r)-24(egistr)-23.9(y d)42(a)15(t)15(a fr)-32(om t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(P)30(er)-10(sistence A)10(ustr)-33(al)-30.9(ian Na)15(t)-32(ional IBD )]TJ 0.001 Tw T* [(Cohor)-22(t $P)25(A)51(NIC$ stud)17.1(y. )]TJ /T1_1 1 Tf [(Alimentar)-42.9(y Phar)-14(macology & Therapeutics)]TJ /T1_0 1 Tf (. 2021 )Tj 0 Tw T* [(A)10(ug;54$3$:292\226301.)]TJ 0.184 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Af)-28(if)]TJ /Span<>> BDC ( )Tj EMC [(W, Ar)-32.9(asar)-33(adnam)]TJ /Span<>> BDC ( )Tj EMC [(RP, A)-14(br)-24(eu)]TJ /Span<>> BDC ( )Tj EMC [(MT, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-17(cy and Safe)-12(t)-9.9(y )]TJ 0.065 Tw -1.796 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Ustek)-16(inumab for Ul)16(cer)-33(a)15(t)-32(i)-16(ve Col)-30.9(i)-24(t)-32(is T)46.9(hr)-31.9(ough 4 Y)30(ear)-10(s: F)-19(inal R)13(esul)56(ts )]TJ -0.016 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he UNIFI L)35(ong-T)40(er)-16(m Maintenance S)15(tud)17.1(y. )]TJ /T1_1 1 Tf (Am J Gastroenterol)Tj /T1_0 1 Tf (. 2024 )Tj 0.019 Tw T* [(Ma)15(y 1;119$5$:910\226921. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14309/ajg.0000000000002621)Tj 0 0 0 1 k /GS1 gs 0.019 Tw ( Epub )Tj 0.023 Tw T* (2023 Dec 14. PMID: 38095692; PMCID: PMC11062601.)Tj 0.167 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sandbor)-15(n)]TJ /Span<>> BDC ( )Tj EMC [(W)31(J, R)13(ebuck)]TJ /Span<>> BDC ( )Tj EMC [(R, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)-19(i)-16(ve-Y)30.1(ear Ef)-56(f)-28(ica)-16.9(cy and )]TJ 0.11 Tw -1.796 -1.187 Td [(Safe)-12(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC 4.027 0 Td [(Ustek)-15.9(inumab )0.5(T)49.9(r)-23.9(ea)15(tment )0.5(in )0.5(Cr)-32(ohn\241s )0.5(Disease: )0.5(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 19.826 0 Td (IM-UNITI )Tj 0.012 Tc -0.012 Tw -23.853 -1.187 Td [(T)49.9(r)-37.1(ial. )]TJ /T1_1 1 Tf 0.447 Tw 2.824 0 Td (Clin Gastroenterol Hepatol)Tj /T1_0 1 Tf [(. 2022 Mar;20$3$:578\226590.e4.)12( )]TJ 0 Tc 0 Tw -2.824 -1.187 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.804 0 Td (10.1016/j.cgh.2021.02.025)Tj 0 0 0 1 k /GS1 gs -0.02 Tw [( Epub 2021 F)10(eb 19. PMID: 33618023; )]TJ 0.023 Tw -1.804 -1.187 Td (PMCID: PMC8374005.)Tj 0.098 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ma)15(tsuok)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(esented a)15(t ECC)13(O, S)14.9(t)17.1(o)-16(ckholm, Sweden, 21)]TJ 0 Tw 4.664 0 0 4.664 516.5055 277.8799 Tm (st)Tj 8 0 0 8 519.9614 275.2159 Tm (\226)Tj -27.082 -1.187 Td (24)Tj 0.013 Tc -0.013 Tw 4.664 0 0 4.664 311.3071 268.3799 Tm (th)Tj 0 Tc 0.144 Tw 8 0 0 8 315.4299 265.7159 Tm [( F)10(ebr)-21.9(uar)-24(y 2024. P1187. P)35(r)-23.9(esented a)15(t ECC)13(O, S)15(t)17(o)-16(ckholm, Sweden, )]TJ 0 Tw -1.515 -1.187 Td (21)Tj 4.664 0 0 4.664 311.3071 258.8799 Tm (st)Tj 8 0 0 8 314.763 256.2159 Tm (\22624)Tj 0.013 Tc -0.013 Tw 4.664 0 0 4.664 327.211 258.8799 Tm (th)Tj 0 Tc 0.023 Tw 8 0 0 8 331.3338 256.2159 Tm [( F)10(ebr)-22(uar)-23.9(y 2024. P1187.)]TJ 0.291 Tw -3.503 -1.187 Td (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Kr)-22(ugl)-30.9(iak Clevel)-16(and)]TJ /Span<>> BDC ( )Tj EMC (N, Ghosh)Tj /Span<>> BDC ( )Tj EMC (S, Chastek)Tj /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(eal-W)20.1(or)-30(ld )]TJ 0.167 Tw -1.796 -1.187 Td [(P)30(er)-10(sistence of)]TJ /Span<>> BDC ( )Tj EMC [(Successi)-15.9(ve Biol)30.1(o)-16(gics in P)40(a)15(t)-32(ients W)-16(i)-24(t)-13(h Infl)-15.9(amma)15(t)17(or)-24(y )]TJ 0.014 Tc 0.513 Tw T* [(Bo)-14(wel Disease: F)-19(indings F)10(r)-32(om ROT)35(AR)-14(Y. )]TJ /T1_1 1 Tf [(Inf)-22(lamm Bow)12(el Dis.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.187 Td [(2024;30$10$:1776\2261787. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/ibd/izad245)Tj 0 0 0 1 k /GS1 gs 0.176 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Car)-32(on)]TJ /Span<>> BDC ( )Tj EMC [(B, Haber)-21.9(t)]TJ /Span<>> BDC ( )Tj EMC [(A, Bonsa)-17(ck)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dif)-56(f)-27.9(icul)56(t-t)17(o-tr)-23.9(ea)15(t infl)-16(am)]TJ 0 Tw (-)Tj 0.053 Tw -1.796 -1.187 Td [(ma)15(t)17(or)-24(y bo)-14(wel disease: ef)-55.9(fec)-16(t)-32(i)-16(veness and safe)-12(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(4t)-13(h and 5t)-13(h l)-31(ines )]TJ 0.109 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment. )]TJ /T1_1 1 Tf [(U)22(nited European Gastroenterol)]TJ /Span<>> BDC ( )Tj EMC (J.)Tj /T1_0 1 Tf ( 2024;12$5$:605\22613. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1002/ueg2.12547)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.467 Tw -1.847 -1.187 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (Gil-Candel)Tj /Span<>> BDC ( )Tj EMC [(M, Gasc\363n-C\341nov)-14.7(as)]TJ /Span<>> BDC ( )Tj EMC [(JJ, U)15.4(r)-23.7(bie)-11.7(t)15.3(a-Sanz)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)13( )]TJ 0 Tc 0.072 Tw -1.847 -1.187 Td [(Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(dr)-22(ug sur)-32(v)-16(i)-16(v)-14.9(al be)-12(t)-32(ween infl)-30.9(iximab and ad)42(al)-31(imumab in )]TJ 0.081 Tw T* [(infl)-16(amma)15.1(t)17(or)-24(y bo)-14(wel disease. )]TJ /T1_1 1 Tf [(Int J Clin Phar)-13.9(m)]TJ /T1_0 1 Tf [(. 2020 Ap)25(r;42$2$:500\226)]TJ 0.186 Tw T* [(507. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11096-020-00978-6)Tj 0 0 0 1 k /GS1 gs 0.186 Tw ( Epub 2020 Jan 31. PMID: )Tj 0 Tw T* (32006141.)Tj 0.001 Tc 0.35 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.801 0 Td [(W)11.8(ang)]TJ /Span<>> BDC ( )Tj EMC [(C, T)44.8(ol)-16.2(a)14.8(yma)14.8(t)]TJ /Span<>> BDC ( )Tj EMC [(M, Cr)-32.2(oss)]TJ /Span<>> BDC ( )Tj EMC [(R. T)46.8(he)]TJ /Span<>> BDC ( )Tj EMC [(Im)9.8(p)31.8(a)-17.2(c)-16.2(t of)]TJ /Span<>> BDC ( )Tj EMC [(Inter)-16.2(media)14.8(te)1( )]TJ 0.002 Tc -1.801 -1.187 Td [(Ant)-32.3(idr)-22.3(ug Ant)-32.2(ibodies t)16.7(o)]TJ /Span<>> BDC ( )Tj EMC [(Infl)-31.2(iximab and A)14.7(d)41.7(al)-31.3(imumab on Cl)-31.2(inical)2( )]TJ 0 Tc 0.004 Tw T* [(Outcomes )0.6(in )0.5(P)40(a)15(t)-32(ients )0.6(wi)-24(t)-13(h )0.6(Cr)-32(ohn\241s )0.5(Disease )0.5(or )0.5(Ul)16(cer)-32.9(a)15(t)-32(i)-16(ve )0.5(Col)-30.9(i)-24(t)-32(is. )]TJ /T1_1 1 Tf 0 Tw 25.778 0 Td (EMJ.)Tj /T1_0 1 Tf ( )Tj 0.023 Tw -25.778 -1.25 Td [(2022;7[1]:84\22693. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33590/emj/21-00149)Tj /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 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1 Td [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-10(\026\n \b\022\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-\b\t\235\f\t\f\017\t\240\002 )]TJ 0 -1 TD [(\210\b\025\013\025\020\b\213\f\205\007\b\002 \223\017\f\223\005\017\005\026\ )11(\025\016 $\031\030\214\034$ \223\017\b\022\016\025\205\223\005\013\b\026\ )11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 )]TJ T* [(\007\b\203\f\213\t\b\007\005 \016\022\017\005\001\t\240\002 \013\b\t\b\002\ \026)11(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-10(\013\b\t\b\216\b\205)-9.9(\026)11(\005 \t\005\022\223\017\025\210\013\f\024\220)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\020)21(\026\027\r\237\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.116 Tw 10 0 0 10 42.5197 700.4739 Tm (\212\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\024\005 \220\235\235\036\022\021\ 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[(\023\036\030\036\022\035\033\004\036\027\017\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.631 0 Td [(\007\030\031\020\024\005 )0.5(\023\030\036\023\026\030\026\021 )0.6(\017/\017\035\017 )0.5(\023\030\036\022\030\026\013\036)]TJ 0 Tw (-)Tj 0.079 Tw -7.631 -1.218 Td [(\027\017\016 )0.5(\035\036\004\036\027\017\016 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\200\003\025 )0.5(\023\024\n\024\032\036\021 \r)]TJ /Span<>> BDC ( )Tj EMC 18.19 0 Td (\023\030\017\027\016\021\017\017 )Tj 0.311 Tw -18.19 -1.218 Td (\024\002\024\f\027\024\r\026\027\027\t\b \030\036\001\036\027\017\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\026\006\017\017 )Tj 0.115 Tw 0 -1.218 TD (\035\036\004\036\002\027\t\b \023\024\007\b\024\007\024\r, \004\021\024 \ \n\024\032\036\021 \023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024 )Tj 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007 \200\003\025.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\226\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_2 1 Tf 0.626 Tw 0 -1.218 TD [(\225)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.8(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_4 1 Tf -0.008 Tc 0.634 Tw [( \216)3.7(\016)-1.4(\036)-2.5(\022\035)-4.4(\024)-4(\021)4.8(\037)-5.9(\030)]TJ /Span<>> BDC 19.435 0 Td ( )Tj EMC [(\213)-10.3(.)20.5(\215)16.4(.,)-8( )]TJ 0 Tc 0 Tw -19.435 -1.218 Td [(\216)11.7(\034)2.4(\b)6.9(\037)4.8(\021)12.8(\022)7.2(\020)9.5(\037)]TJ /Span<>> BDC ( )Tj EMC [(\205)22.8(.)27.5(\225)26.6(.)7.8(, \200)51.8(\016)-5.1(\025\016)-0.9(\033\005)5.4(\022)3.8(\016)6.6(\036)2.1(\037)]TJ /Span<>> BDC ( )Tj EMC [(\240)19.4(.)28.6(\215)24.3(.)7.8(, \230\016)-20.6(\027)3.3(\034)4.9(\023)6.6(\024)9.9(\034)9.6(\036)2.1(\037)]TJ /Span<>> BDC ( )Tj EMC [(\205)22.8(.)7.3(\213)-2.3(.)]TJ /T1_2 1 Tf 0.002 Tc -0.002 Tw 0 -1.218 TD [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \216)11.7(\016)6.6(\036)5.5(\022)7.7(\035)3.7(\024)4(\021)12.7(\037)2.1(\030)]TJ /Span<>> BDC ( )Tj EMC [(\213)-2.3(.)28.5(\215)24.3(.)7.8(, \230\016)-20.6(\027)3.3(\034)4.9(\023)6.6(\024)9.8(\034)9.6(\036)2.2(\037)]TJ /Span<>> BDC ( )Tj EMC [(\205)22.8(.)7.3(\213)-2.3(.)]TJ /T1_2 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \230)-9.8(\016)-30.6(\027)-6.6(\034)-5.1(\023)-3.4(\024\034\036)-7.9(\037)]TJ /Span<>> BDC 11.528 0 Td ( )Tj EMC [(\205)12.8(.)-2.7(\213)-12.2(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -11.528 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_2 1 Tf 2.065 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(d)0.8(a)-8.4(t)-27.7(a)4.2(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0.621 Tw T* [(A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-3.6(e)-4(v)-28.6(i)1(t)-29.1(s)9.1(k)15.8(a)-5.9(y)3.8(a)-14(, E)20.6(k)15.9(a)-4.9(t)2.8(e)-1.7(r)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(. L)-5.5(om)4.3(a)1.7(k)-18.5(i)8.5(n)4.8(a)-14(, )]TJ 0 Tw T* [(M)5.2(ar)-35.3(i)5.9(a)-0.8(n)4.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(T)46.8(e)-1.1(b)-5.9(e)-1.6(r)1.4(d)1.4(i)3(e)-4(v)10.8(a)-14(, E)19.6(l)4.8(e)-2.6(n)4.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(e)-1.9(l)2.9(o)0.9(us)4.9(o)-0.6(v)10.8(a)]TJ /T1_2 1 Tf -0.052 Tc 0.005 Tw 23.244 32.881 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-100(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_4 1 Tf 0 Tc -0.047 Tw 5.186 0 Td [( A)3.8(n)4.8(a)-3(s)-10.6(t)2.3(a)-3(s)-8.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-3.6(e)-4(v)-28.6(i)0.9(t)-29(s)9.1(k)15.8(a)-5.9(y)3.8(a)-14(, E)19.7(l)4.8(e)-2.6(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(e)-1.9(l)2.9(o)0.9(us)4.9(o)-0.6(v)10.8(a)]TJ /T1_2 1 Tf 0.006 Tc -0.006 Tw -5.186 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf -0.005 Tc 0.005 Tw 3.238 0 Td [( E)14.6(le)-7.6(na)]TJ /Span<>> BDC 2.365 0 Td ( )Tj EMC [(A)-17.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(B)-4.2(e)-6.9(l)-2.1(o)-4.1(u)-5.1(so)-5.6(v)5.8(a)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -6.682 -2.436 Td (\255\026\036\031\036\025\034\222 \017\225 \032\026\020\017\022\032\233 $\ ORCID$)Tj /T1_2 1 Tf 0.469 Tw T* (\214\036\r\017\021\f\022\026\016 \202\027\026\f\021\026\f\017\016 \200\035\ \026\007\017\n\017\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \026\f\023\017\030\026\027\021 )Tj 0.249 Tw T* (\022\026\235\036\007\030\t \020\026\f\021\030\024\220\027\021\036\030\024\ \035\024\020\017\017 \206\207\211\003 \204\210 \204\210\203\230\025\230 \ \017\n. )Tj 0 Tw T* (\204.\205.)Tj /Span<>> BDC ( )Tj EMC (\200\035\026\007\017\n\017\030\f\022\024\020\024; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-3282-5093)Tj 0.01 Tc 0.397 Tw 0 -1.218 TD [(\207\036\035\024\031\f\024\r\026 )0.5(\213\035\036\027\026 )0.5(\202\035\036\022\f\026\027\007\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 15.216 0 Td [(\227 )0.5(\007.\n.\027., )0.5(\023\030\024)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.348 Tw -15.216 -1.218 Td [(\235\036\f\f\024\030, )0.5(\030\031\022\024\r\024\007\017\021\036\035\034 )0.5(\024\021\007\036\035\036\027\017\016 )0.5(\020\026\f\021\030\024\220\027\021\036\030\024\035\024)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.263 Tw 0 -1.218 TD (\020\017\017 \206\207\211\003 \204\210 \204\210\203\230\025\230, \026\r\ \036\007\031\033\013\026\016 \022\026\235\036\007\030\024\005 \020\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.445 Tw T* [(\f\021\030\024\220\027\021\036\030\024\035\024\020\017\017 \205\026\022\031\ \035\034\021\036\021\026 \031\f\024\r\036\030\001\036\027\f\021\r\024\r\026\ \027\017\016)10( )]TJ 0.334 Tw T* [(\r\030\026\004\036\005, )0.5(\215\030\036\017\007\036\027\021 )0.5(\217\024\f\f\017\005\f\022\024\020\024 )0.5(\024\002\013\036\f\021\r\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 20.793 0 Td (\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.341 Tw -20.793 -1.218 Td [(\031\004\036\027\017\033 \r\024\f\023\026\035\017\021\036\035\034\027\t\b\ \026\002\024\035\036\r\026\027\017\005 \022\017\001\036\004\027\017\022\ \026;)10( )]TJ 0.188 Tw 0 -1.218 TD (SPIN-\022\024\007: 6690\2269839)Tj /Span<>> BDC ( )Tj EMC [(A)10(ut)-13(horID: 673790 SC)13(OPUS ID)10( )]TJ 0 Tw 0 -1.218 TD (24278783200; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-4523-337)Tj 0 Tc 0.038 Tw 0 -1.218 TD [(\214\024\n\026\022\017\027\026 )0.5(\213\022\026\021\036\030\017\027\026 )0.6(\222\030\034\036\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.786 0 Td [(\227 )0.5(\027\026\031\004\027\t\005 )0.6(\f\024\021\030\031\007\027\017\022 )]TJ 0.249 Tw -12.786 -1.218 Td (\022\026\235\036\007\030\t \020\026\f\021\030\024\220\027\021\036\030\024\ \035\024\020\017\017 \206\207\211\003 \204\210 \204\210\203\230\025\230 \ \017\n. )Tj 0 Tw 0 -1.218 TD (\204.\205. \200\035\026\007\017\n\017\030\f\022\024\020\024; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-7703-8328)Tj 0.01 Tc 1.101 Tw 0 -1.218 TD (\224\036\002\036\030\007\017\036\r\026 \204\026\030\034\016\027\026 \200\ \016\004\036\f\035\026\r\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 1.257 Tw 0 -1.218 TD [(\031\004\027\t\005 )0.5(\f\024\021\030\031\007\027\017\022 )0.6(\022\026\235\036\007\030\t )0.6(\020\026\f\021\030\024\220\027\021\036\030\024\035\024)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.357 Tw T* [(\020\017\017 \206\207\211\003 \204\210 \204\210\203\230\025\230 \017\n. \ \204.\205. \200\035\026\007\017\n\017\030\f\022\024\020\024;)10( )]TJ 0 Tw 0 -1.218 TD (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0001-9083-2617)Tj /T1_3 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS $ORCID$)Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(Anast)15(asia V. L)35.1(ev)-16(i)-24(tsk)-16.9(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3282-5093)Tj T* [(Elena A. Bel)30.1(ousov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4523-337)Tj T* [(Ek)-17(a)15(ter)-36.9(ina Y)35(u. L)35(omak)-15.9(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7703-8328)Tj T* [(Mar)-37(iana V. T)40.1(eber)-24(diev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-9083-2617)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 359.4899 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.036 Tw 8 0 0 8 42.5197 347.1552 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ng)Tj /Span<>> BDC ( )Tj EMC [(SC, S)-16(hi)]TJ /Span<>> BDC ( )Tj EMC (HY, Hamidi)Tj /Span<>> BDC ( )Tj EMC [(N, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. W)20(or)-30(ld)-17(wide inc)-24(idence and p)25(r)-24(ev)-15(alence )]TJ 0.221 Tw -1.296 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC [(infl)-16(amma)15(t)17(or)-24(y bo)-14(wel disease in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(21st centur)-23.9(y: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic )]TJ -0.01 Tw 0 -1.187 TD [(r)-24(ev)-15.9(iew of)]TJ /Span<>> BDC ( )Tj EMC [(popul)-15.9(a)15(t)-32(ion-based studies. )]TJ /T1_4 1 Tf 0 Tw (Lancet)Tj /T1_2 1 Tf -0.01 Tw (. 2018;390$10114$:2769\226)Tj 0 Tw T* (2778.)Tj 0.184 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Al)-16(a)15(t)15.1(ab)]TJ /Span<>> BDC ( )Tj EMC [(S, Sep)32(anl)30(ou)]TJ /Span<>> BDC ( )Tj EMC [(SG, Ikut)15.1(a)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(gl)30.1(obal, r)-23.9(egional, and )]TJ 0.026 Tw -1.296 -1.187 Td [(na)15(t)-32(ional bur)-24(den of)]TJ /Span<>> BDC ( )Tj EMC [(infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease in 195 countr)-37(ies and )]TJ 0.097 Tw T* [(ter)-24(r)-36.9(i)-24(t)17(or)-37(ies, 1990\2262017: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic anal)35(y)-12.9(sis for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Gl)30(obal Bur)-23.9(den )]TJ 0.202 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Disease S)15.1(tud)17(y 2017. )]TJ /T1_4 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Lancet g)12(astroenterology & hepatology.)]TJ /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2020 Jan 1;5$1$:17\22630.)Tj 0.01 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)60(ur)-15(ner)]TJ /Span<>> BDC ( )Tj EMC [(D, R)-24(icc)-24(iut)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(A, L)35(ewis)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inter)-14.9(na)15(t)-32(ional Or)-32(ganiza)15(t)-32(ion for )]TJ 0 Tw -1.296 -1.187 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(S)15(tud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(IBD. S)-21(TRIDE-II: An)]TJ /Span<>> BDC ( )Tj EMC [(U)13(pd)42(a)15(te on t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Selec)-16(t)-32(ing T)47(her)-32.9(apeut)-32(ic )]TJ 0.015 Tc 0.543 Tw T* [(T)40.1(ar)-31.8(ge)-11.8(ts in Infl)-15.8(amma)15.1(t)17.2(or)-23.9(y Bo)-13.8(wel Disease $S)-20.8(TRIDE$ Ini)-23.8(t)-31.9(ia)15.1(t)-31.8(i)-15.8(ve)15( )]TJ 0 Tc 0.254 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he Inter)-15(na)15(t)-32(ional Or)-32(ganiza)15(t)-32(ion for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(S)15(tud)17.1(y of)]TJ /Span<>> BDC ( )Tj EMC (IBD $IOIBD$: )Tj 0.036 Tw T* [(De)-12(ter)-16(mining T)47(her)-32.9(apeut)-32(ic Goals for T)50(r)-24(ea)15(t-t)17.1(o-T)40(ar)-32(ge)-12(t str)-33(a)15(tegies in IBD. )]TJ /T1_4 1 Tf 0 Tw T* (Gastroenterology)Tj /T1_2 1 Tf 0.154 Tw [(. )0.5(2021 )0.5(Ap)25(r;160$5$:1570\2261583. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 21.62 0 Td (10.1053/j.gas)Tj (-)Tj -21.62 -1.187 Td [(tr)-32(o.2020.12.031)]TJ 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2021 F)10(eb 19. PMID: 33359090.)]TJ -0.028 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \230\r\026\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\224., \207\036\035\024\031\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \254\r\036\027\027\t\005 )Tj 0.011 Tc 0.409 Tw -1.296 -1.187 Td (\022\024\035\017\021 $\02551$, \r\030\024\f\035\t\036. )Tj /T1_4 1 Tf -0.011 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_2 1 Tf 0.409 Tw [(. 2023;22$1$:10\22644.)11( )]TJ 0.015 Tc -0.015 Tw T* [(d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.46 0 Td (10.33878/2073-7556-2023-22-1-10-44)Tj 0 0 0 1 k /GS1 gs 0.56 Tw [( )0.5(/ )0.5(S)-16.3(hel)34.7(ygin )0.6(Y)34.6(u.A.,)15.1( )]TJ 0 Tc 0.081 Tw -2.46 -1.187 Td [(Iv)-15(ashk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(V.T., Bel)30(ousov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(E.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ul)16(cer)-33(a)15(t)-32(i)-15.9(ve col)-31(i)-23.9(t)-32(is $K51$, adul)56(ts. )]TJ /T1_4 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_2 1 Tf 0.039 Tw [(. 2023;22$1$:10\22644. $in Russ.$. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2023-22-1-10-44)Tj 0 0 0 1 k /GS1 gs 0.111 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hanzel)Tj /Span<>> BDC ( )Tj EMC (J, Supovec)Tj /Span<>> BDC ( )Tj EMC [(E, Smr)-24(ek)-16.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. SING $S)-16(l)30.1(ovenian Na)15(t)-32(ional )]TJ -0.046 Tw -1.296 -1.187 Td [(IBD S)15(tud)17(y )0.5(G)20(r)-32(oup$, Dr)-22(ug sur)-31.9(v)-16(i)-16(v)-15(al of)]TJ /Span<>> BDC ( )Tj EMC 13.696 0 Td [(f)-28(ir)-10(st-l)-31(ine biol)30(o)-16(gics )0.5(in infl)-16(amma)15(t)17.1(or)-24(y )]TJ 0.006 Tw -13.696 -1.187 Td [(bo)-14(wel disease: )0.5(l)-16(ar)-32(ge single-centr)-23.9(e e)-18(xper)-37(ience fr)-31.9(om UR-C)20(ARE, )]TJ /T1_4 1 Tf 0 Tw [(Jour)-13.9(nal )]TJ 0.014 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC 1.043 0 Td [(Crohn\245s )0.5(and Colitis. )]TJ /T1_2 1 Tf [(2023 F)10(eb;17$1$:i850\226i851. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.663 0 Td (10.1093/ecco-)Tj -21.706 -1.187 Td [(jcc/jja)-17(c190.0850)]TJ 0 0 0 1 k /GS1 gs -0.079 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \230\r\026\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\224., \202\004\022\026\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\225.\230., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 )Tj -0.027 Tw -1.296 -1.187 Td (\030\036\022\024\n\036\027\007\026\006\017\017. \207\024\035\036\027\034\ \025\030\024\027\026 $\02550$, \r\030\024\f\035\t\036. )Tj /T1_4 1 Tf 0 Tw (\r\034\027\034\f\033\034\021\035\034\027\034\013\022\030)Tj /T1_2 1 Tf (. )Tj 0.005 Tc 0.35 Tw 29.055 33.25 Td [(2023;22$3$:10\22649. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.005 Tw (10.33878/2073-7556-2023-22-3-10-49)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.355 Tw ( / )Tj -0.016 Tw T* [(S)-16(hel)35(ygin Y)35(u.A., Iv)-15(ashk)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(V.T., A)-25(chk)-16.9(asov)]TJ /Span<>> BDC ( )Tj EMC [(S.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-30.9(inical guidel)-31(ines. )]TJ -0.019 Tw T* [(Cr)-32(ohn\241s )0.5(disease )0.5($K50$, )0.5(adul)56.1(ts. )]TJ /T1_4 1 Tf 0 Tw 11.898 0 Td [(K)18(olop)46(roktologia)]TJ /T1_2 1 Tf -0.019 Tw [(. )0.5(2023;22$3$:10\22649. )0.5($in )]TJ 0.023 Tw -11.898 -1.187 Td [(Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2023-22-3-10-49)Tj 0 0 0 1 k /GS1 gs 0.11 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)45(or)-24(r)-23.9(es)]TJ /Span<>> BDC ( )Tj EMC [(J, Bonov)-15(as)]TJ /Span<>> BDC ( )Tj EMC [(S, Doher)-22(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. ECC)13(O guidel)-31(ines on t)-12.9(her)-33(a)]TJ 0 Tw (-)Tj 0.048 Tw -1.296 -1.187 Td [(peut)-32(ics in Cr)-32(ohn\241s disease: medical tr)-24(ea)15(tment. )]TJ /T1_4 1 Tf (J Crohns Colitis.)Tj /T1_2 1 Tf ( 2020 )Tj 0.023 Tw T* (Jan 1;14$1$:4\22622.)Tj 0.012 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(aine)]TJ /Span<>> BDC ( )Tj EMC [(T, Bonov)-15(as)]TJ /Span<>> BDC ( )Tj EMC [(S, Bur)-36.9(isch)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. ECC)13(O guidel)-30.9(ines on t)-12.9(her)-33(apeu)]TJ 0 Tw (-)Tj 0.166 Tw -1.296 -1.187 Td [(t)-32(ics in ul)16(cer)-33(a)15(t)-32(i)-16(ve col)-31(i)-23.9(t)-32(is: medical tr)-24(ea)15(tment. )]TJ /T1_4 1 Tf (J Crohn\245s and Colitis. )Tj /T1_2 1 Tf 0.023 Tw T* (2022 Jan;16$1$2\22617.)Tj 0.015 Tc 0.551 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.341 0 Td (\025\027\016\036\r)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \221\022\031\030\022\024)Tj /Span<>> BDC ( )Tj EMC (\224.\200., \025\026\020\030\026\n\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)15( )]TJ 0.023 Tc 0.844 Tw -1.341 -1.187 Td [(\237\023\017\007\036\n\017\024\035\024\020\017\016 \r\024\f\023\026\035\017\ \021\036\035\034\027\t\b \026\002\024\035\036\r\026\027\017\005 \022\017\ \001\036\004\027\017\022\026.)23( )]TJ 0 Tc 0.289 Tw T* (\225\024\f\021\024\016\027\017\036 \023\030\024\002\035\036\n\t $\024\002\ \024\030$. )Tj /T1_4 1 Tf (\255\034\024\024\022\t\024\021\022\t \020\037\023\n\020\034-\034\025\034\ \024\020\034\036\037\020\020\032\t )Tj 0.046 Tw T* (\013\037\024\035\033\034\220\020\035\016\033\034\027\034\013\022\n\016\024\ \021\022\t \003\023\033\020\037\027)Tj /T1_2 1 Tf [(. 2020;9$2$:66\22673 / Knia)-24(zev)]TJ /Span<>> BDC ( )Tj EMC (O.V., )Tj 0.166 Tw T* [(S)-16(hkur)-23.9(ko)]TJ /Span<>> BDC ( )Tj EMC [(T.V., K)-16(a)-17(gr)-33(amanov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Epidemiol)30(o)-16(g)16(y of)]TJ /Span<>> BDC ( )Tj EMC [(infl)-15.9(amma)]TJ 0 Tw (-)Tj 0.132 Tw T* [(t)17(or)-24(y )0.6(bo)-14(wel )0.6(disease. )0.5(S)15(t)15(a)15(te )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 11.928 0 Td [(t)-13(he )0.6(p)25(r)-32(oblem )0.5($r)-23.9(ev)-16(iew$. )]TJ /T1_4 1 Tf 9.393 0 Td [(R)22(ussian )0.6(Jour)-14(nal )]TJ 0.023 Tw -21.321 -1.187 Td (of)Tj /Span<>> BDC ( )Tj EMC (Evidence-Based Gastroenterology)Tj /T1_2 1 Tf (. 2020;9$2$:66\22673. $in Russ.$.)Tj 0.076 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ed)-17(w)-12(ar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(B, Har)-24(r)-36.9(is)]TJ /Span<>> BDC ( )Tj EMC (A, Joe)Tj /Span<>> BDC ( )Tj EMC [(Z, Ant)17(oine)]TJ /Span<>> BDC ( )Tj EMC (S, James)Tj /Span<>> BDC ( )Tj EMC (C, Joehl)Tj /Span<>> BDC ( )Tj EMC [(N, Der)-23.9(ek)]TJ /Span<>> BDC ( )Tj EMC (G, )Tj 0.202 Tw -1.796 -1.187 Td [(Jane)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(H, Jul)-31(ie)]TJ /Span<>> BDC ( )Tj EMC [(C, Mill)-30.9(ie)]TJ /Span<>> BDC ( )Tj EMC (L, John)Tj /Span<>> BDC ( )Tj EMC [(H. P027. F)20(a)-17(c)-16(t)17(or)-10(s Asso)-15.9(c)-24(ia)15(ted wi)-24(t)-12.9(h )]TJ 0.009 Tc 0.35 Tw T* [(Biol)29.6(o)-16.3(gic Discont)-32.3(inua)14.7(t)-32.3(ion in P)39.7(a)14.7(t)-32.3(ients wi)-24.3(t)-13.3(h Infl)-16.3(amma)14.6(t)16.7(or)-24.3(y Bo)-14.3(wel)9( )]TJ 0 Tc 0.152 Tw T* [(Disease in T)35(ARGET-IBD. )]TJ /T1_4 1 Tf (Am J Gastroenterol.)Tj /T1_2 1 Tf ( 2020 Dec 1;115$Suppl )Tj -0.044 Tw T* [(1$:S7. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.14309/01.ajg.0000722904.81509.45)Tj 0 0 0 1 k /GS1 gs -0.044 Tw ( PMID: 33566501.)Tj 0.11 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Khan)Tj /Span<>> BDC ( )Tj EMC [(S, Rupniewsk)-16.9(a)]TJ /Span<>> BDC ( )Tj EMC [(E, Neighbor)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(eal w)-14(or)-29.9(ld ev)-16(idence )]TJ 0.002 Tc 0.35 Tw -1.796 -1.187 Td [(on adher)-24.3(ence, per)-10.4(sistence, swi)-24.4(tching and d)-16.3(ose escal)-16.3(a)14.7(t)-32.4(ion wi)-24.3(t)-13.3(h)2( )]TJ 0 Tc 0.087 Tw T* [(biol)30(o)-16(gics in adul)56(t infl)-16(amma)15(t)17(or)-23.9(y bo)-14(wel disease in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(U)13(ni)-24(ted S)15(t)15(a)15(tes: )]TJ 0.133 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(clinical phar)-14(macy and therapeutics.)]TJ /T1_2 1 Tf 0 Tw ( )Tj T* (2019;44$4$:495\226507.)Tj -0.012 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Chen)Tj /Span<>> BDC ( )Tj EMC [(C, Har)-22(tzema)]TJ /Span<>> BDC ( )Tj EMC [(A)16(G, Xiao)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(eal-w)-13.9(or)-30(ld p)32(a)15(t)-30(ter)-15(n of)]TJ /Span<>> BDC ( )Tj EMC [(biol)30(o)-15.9(gic )]TJ 0.097 Tw -1.796 -1.187 Td [(use in p)32(a)15(t)-32(ients wi)-24(t)-12.9(h infl)-15.9(amma)15(t)17(or)-24(y bo)-14(wel disease: tr)-23.9(ea)15(tment per)-9.9(sis)]TJ 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 504.6396 56.0378 Tm (113)Tj ET endstream endobj 513 0 obj <>/Border[0 0 0]/H/N/Rect[215.478 221.451 263.622 211.995]/Subtype/Link/Type/Annot>> endobj 514 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 211.951 95.2152 202.655]/Subtype/Link/Type/Annot>> endobj 515 0 obj <>/Border[0 0 0]/H/N/Rect[62.1972 183.451 193.169 174.155]/Subtype/Link/Type/Annot>> endobj 516 0 obj <>/Border[0 0 0]/H/N/Rect[210.894 164.451 263.622 154.995]/Subtype/Link/Type/Annot>> endobj 517 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 154.951 116.599 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[(\f\036\020\024\007\027\016\001\027\017\005 )0.5(\007\036\027\034 )0.5(\027\036\021 )0.6(\004\036\021\022\024\020\024 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.202 Tw -7.859 -1.218 Td (\027\017\n\026\027\017\016 \024\004\036\030\036\007\027\024\f\021\017 \027\ \026\027\026\004\036\027\017\016 \206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 0.16 Tw 0 -1.218 TD (\023\036\030\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\b \035\017\027\017\005 \021\036\030\ \026\023\017\017. \225\031\013\036\f\021\r\031\033\021 )Tj 0.226 Tw T* (\030\026\027\024\024\002\030\026\027\t\036, \023\030\024\021\017\r\024\ \030\036\004\026\013\017\036 \007\030\031\020 \007\030\031\020\031 \017\f\ \f\035\036)Tj 0 Tw (-)Tj 0.076 Tw T* (\007\024\r\026\027\017\016, \020\007\036 \017\f\023\024\035\034\024\r\026\ \035\017\f\034 \030\026\027\t\036 \f\021\026\021\017\f\021\017\004\036\f\ \022\017\036 )Tj 0.151 Tw T* (\n\036\021\024\007\t. \211\004\017\021\t\r\026\016, \004\021\024 \r\021\024\ \030\017\004\027\026\016 \023\024\021\036\030\016 \024\021\r\036\021\026\ \004\026)Tj 0 Tw (-)Tj 0.229 Tw 0 -1.218 TD (\f\021\024 \f\r\016\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n\017 \235\026\022\021\024\030\026\n\017, \022\026\022 \ \024\002\030\026\024\r\026\027\017\036 )Tj 0.317 Tw 0 -1.218 TD (\026\027\021\017\021\036\035, \027\036\024\002\b\024\007\017\n\024 \023\024\ \f\021\024\016\027\027\024 \031\007\036\035\016\021\034 \r\027\017\n\026\ \027\017\036 )Tj 0.493 Tw T* [(\035\036\022\026\030\f\021\r\036\027\027\024\n\031 )0.6(\n\024\027\017\021\024\030\017\027\020\031, )0.6(\004\021\024\002\t )0.5(\024\023\021\017\n\017\017\030\024)]TJ 0 Tw (-)Tj 0.291 Tw T* [(\r\026\021\034 \021\036\030\026\023\017\033. \210\007\027\024\027\026\004\ \027\t\b )0.5(\022\030\017\021\036\030\017\036\r \023\024\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.115 Tw T* (\021\036\035\034\027\024\f\021\017 \017\f\023\024\035\034\024\r\026\027\ \017\016 \206\230\207\215 \023\024\022\026 \027\036 \f\031\013\036\f\021\ \r\031\036\021. )Tj 0.166 Tw T* (\212\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\030\017\021\036\021\027\024\f\021\017 \023\030\017\n\036\ \027\036\027\017\016 \021\036\b \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\t\b )Tj 0.153 Tw 0 -1.218 TD (\206\230\207\215 \024\020\030\026\027\017\004\036\027\t. \215\030\024\002\ \035\036\n\026 \024\006\036\027\022\017 \r\t\032\017\r\026\036\n\024\f\021\ \017 )Tj -0.004 Tw 0 -1.218 TD (\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\017\026\006\017\017 \f\b\036\n \035\036\004\036\027\017\ \016 \f\021\024\017\021 \024\f\024\002\036\027\027\024 )Tj 0 Tw 0 -1.218 TD (\024\f\021\030\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \200\003\025.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 517.8038 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.006 Tc 0.242 Tw 10 0 0 10 70.8661 493.4478 Tm (\224\026\022\017\n \024\002\030\026\024\n, \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \027\036\021\ \004\036\021\022\024\020\024)6( )]TJ 0.231 Tw T* [(\023\024\027\017\n\026\027\017\016 )0.5(\024\004\036\030\036\007\027\024\f\021\017 )0.5(\027\026\027\026\004\036\027\017\016 )0.5(\206\230\207\215 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.873 0 Td (\022\026\004\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.008 Tw -19.873 -1.218 Td (\f\021\r\036 \023\036\030\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\b \035\017\027\017\005 \021\036\030\ \026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\200\003\025.)6( )]TJ 0.087 Tw T* [(\215\030\036\023\026\030\026\021\t, \022\026\022 \023\030\026\r\017\035\024\ , \027\026\027\026\004\026\033\021\f\016 \220\n\023\017\030\017\004\036\ \f\022\017,)6( )]TJ 0.251 Tw T* (\002\036 \031\004\036\021\026 \024\f\024\002\036\027\027\024\f\021\036\005\ \023\026\006\017\036\027\021\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\f\024\002\036\027\027\024\f\021\036\005)6( )]TJ 0.193 Tw T* (\035\036\022\026\030\f\021\r\036\027\027\024\020\024 \f\030\036\007\f\021\ \r\026. \215\030\024\002\035\036\n\026 \024\006\036\027\022\017 \r\t\032\ \017)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc -0.031 Tw T* (\r\026\036\n\024\f\021\017 \021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\023\021\017\n\017\026\006\017\017 \f\b\036\n \035\036\004\036\027\017\ \016 \f\021\024\017\021)6( )]TJ -0.005 Tw T* (\024\f\024\002\036\027\027\024 \024\f\021\030\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\030\026\023\017\017 \200\003\025. \003\027\026\027\017\036 \007\ \035\017\021\036\035\034\027\024\f\021\017)6( )]TJ 0.105 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\017 \030\026\027\t\b \206\230\207\215\ \017)Tj /Span<>> BDC ( )Tj EMC [(\235\026\022\021\024\030\024\r, \r\035\017\016\033\013\017\b)6( )]TJ 0.076 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\t\032\017\r\026\036\n\024\f\021\034, \n\024\032\036\021 \002\t\021\034\ \b\024\030\024\001\017\n \023\024\007\f\023\024\030\034\036\n)6( )]TJ 0.64 Tw T* [(\007\035\016 \023\024\027\017\n\026\027\017\016 \023\024\f\035\036\007\024\ \r\026\021\036\035\034\027\024\f\021\017 \027\026\027\026\004\036\027\017\ \016)6( )]TJ 0.049 Tw T* (\023\030\036\023\026\030\026\021\024\r, \027\024 \007\024\035\032\036\027\ \002\t\021\034 \036\007\017\027\t\005 \023\024\007\b\024\007 \022)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.073 Tw T* [(\022\036 \023\024\022\026\026\021\036\035\016 \r\t\032\017\r\026\036\n\024\ \f\021\017. \204\t \027\036 \f\021\026\r\017\035\017 \006\036\035\034\033\ )6( )]TJ 0.124 Tw T* [(\220\021\024\005 \030\026\002\024\021\t \023\030\024\r\036\007\036\027\017\ \036 \f\017\f\021\036\n\026\021\017\004\036\f\022\024\020\024 \026\027\026\ \035\017\026)6( )]TJ 0.014 Tw T* [(\f\031\013\036\f\021\r\031\033\013\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.314 0 Td [(\007\024\022\026\026\021\036\035\034\f\021\r )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 7.458 0 Td (\r\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.059 Tw -20.772 -1.218 Td (\023\030\024\f\031 \r\t\032\017\r\026\036\n\024\f\021\017 \206\230\207\215\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\200\003\025. \203\026\001\036\005 \026\007\026\004\036\005)6( )]TJ 0.254 Tw T* (\002\t\035\024 \024\006\036\027\017\021\034 \f\024\f\021\024\016\027\017\ \036 \220\021\024\005 \023\030\024\002\035\036\n\t, \023\030\036\007\f\021\ \026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.139 Tw T* (\r\017\021\034 \023\030\026\022\021\017\022\026\n-\022\035\017\027\017\006\ \017\f\021\026\n \024\002\013\036\036 \023\024\035\024\032\036\027\017\036\ \r\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.048 Tw T* [(\013\036\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\024\n\031 )0.5(\r\024\023\030\024\f\031 \017)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\022\026\026\021\034, \004\021\024 )0.5(\024\006\036\027\022\026 \r\t\032\017)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.14 Tw T* [(\r\026\036\n\024\f\021\017 \206\230\207\215 \n\024\032\036\021 \002\t\021\ \034 \031\007\024\002\027\t\n \017\027\f\021\030\031\n\036\027\021\024\n\ )6( )]TJ 0.077 Tw T* [(\007\035\016 \023\030\024\020\027\024\017\030\024\r\026\027\017\016 \007\ \024\035\020\024\f\030\024\004\027\024\005 \220\235\235\036\022\021\017\r\ \027\024\f\021\017)6( )]TJ 0.131 Tw T* (\023\030\036\023\026\030\026\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\031\013\036\f\021\ \r\031\033\021 \030\026\027\024\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.118 Tw T* [(\002\030\026\027\t\036 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 5.26 0 Td [(\007\017\026\005\027\031, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 5.336 0 Td [(\022\024\035\017\004\036\f\021\r\031 )0.5(\024\002\f\035\036\007\024\r\026\027\027\t\b)6.1( )]TJ 0.368 Tw -10.596 -1.218 Td (\023\026\006\017\036\027\021\024\r, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\026\n \024\006\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\t\n \021\024\004)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.233 Tw T* (\022\026\n, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\033 \027\026\006\017\024\027\026\ \035\034\027\t\b \002\026 \007\026\027\027\t\b)6( )]TJ 0.182 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\036\030\017\016\n \f\035\031\004\026\036\r, \027\026\002\035\033\007\026\ \021\036\035\034\027\t\036 \023\030\024\f\023\036\022\021\017\r\027\t\036\ )6( )]TJ 0.474 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.236 0 Td [(\030\036\021\030\024\f\023\036\022\021\017\r\027\t\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.5(\017\f\023\024\035\034\031\033\013\017\036)6( )]TJ 0.279 Tw -1.236 -1.218 Td (\030\026\027\t\036 \f\021\026\021\017\f\021\017\004\036\f\022\017\036 \n\ \036\021\024\007\t \024\002\030\026\002\024\021\022\017 \030\036\031\035\ \034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.274 Tw T* [(\021\026\021\024\r. \225\031\013\036\f\021\r\031\033\021 \021\026\022\032\ \036 \f\017\f\021\036\n\026\021\017\004\036\f\022\017\036 \024\002\024\030\ \t)6( )]TJ 0.216 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\t \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\024\n\031 \r\024\023\030\024\f\031, \027\024 \023\024\f\ \022\024\035\034\022\031)6( )]TJ 0.447 Tw T* [(\023\024\016\r\035\016\033\021\f\016 \027\024\r\t\036 \023\030\036\023\026\ \030\026\021\t \017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024,)6( )]TJ 0.201 Tw T* (\027\024\r\t\036 \017\f\f\035\036\007\024\r\026\027\017\016, \021\024 \220\ \021\017 \026\027\026\035\017\t \002\t\f\021\030\024 \031\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.185 Tw T* (\030\036\r\026\033\021, \021\026\022 \022\026\022 \r\024\027\017\022\026\ \036\021 \027\036\024\002\b\024\007\017\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\024\r\t\b)6( )]TJ 0.042 Tw T* (\f\030\026\r\027\036\027\017\016\b. \215\024\022\026 \r\f\036 \220\021\017\ \017\f\f\035\036\007\024\r\026\027\017\016 \021\030\031\007\027\024 \f\r\ \036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.123 Tw T* (\f\021\017 \r\024\036\007\017\027\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\021\030\024\017\021\034 \022\026\022\024\005-\021\024 \024\002\013\ \017\005 \026\035\020\024\030\017\021\n)6( )]TJ 0.362 Tw 23.244 64.543 Td [(\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017 \027\026\ \027\026\004\036\027\017\016 \206\230\207\215, \021\036\n \002\024\035\036\ \036)6( )]TJ 0.024 Tw 0 -1.218 TD (\004\021\024 \030\036\031\035\034\021\026\021\t \004\026\f\021\024 \023\ \030\024\021\017\r\024\030\036\004\026\021 \007\030\031\020 \007\030\031\ \020\031. \225)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc -0.015 Tw 0 -1.218 TD [(\001\036\005 \021\024\004\022\017 \030\036\027\017\016 \n\024\032\027\024\ \f\235\024\030\n\031\035\017\030\024\r\026\021\034 \027\036\f\022\024\035\ \034\022\024)6( )]TJ 0.243 Tw 0 -1.218 TD [(\022\035\033\004\036\r\t\b \023\024\f\021\031\035\026\021\024\r, \024\021\ \030\026\032\026\033\013\017\b \f\031\021\034 \023\030\024\002\035\036\n\ \t)6( )]TJ 0 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034:)Tj 0 Tc 0.012 Tw 0 -1.218 TD (\232)Tj /Span<>> BDC [( )-255( )]TJ EMC 1 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 1.865 0 Td [(\023\030\017\n\036\027\036\027\017\017 )0.6(\206\230\207\215 )0.5(\027\036\017\002\036\032\027\024 )0.5(\r\024\027\017\022\026\036\021 )0.6(\023\024\021\036)]TJ 0 Tw (-)Tj 0.103 Tw -1.865 -1.218 Td (\030\016 \024\021\r\036\021\026 \022)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n, )Tj 0.265 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \n\024\032\036\021 \023\024\021\030\036\002\024\r\026\021\034\ \f\016 \027\036\f\022\024\035\034)Tj 0 Tw (-)Tj 0.233 Tw T* (\022\024 \023\024\f\035\036\007\024\r\026\021\036\035\034\027\t\b \035\017\ \027\017\005 \206\230\207\215 \007\035\016 \017\027\007\031\022\006\017\017\ )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\007\036\030\032\026\027\017\016 \030\036\n\017\f\f\017\017;\ )Tj -0.038 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-305( )]TJ EMC 1 0 Td (\200\t\002\024\030 \023\036\030\r\024\020\024 \206\230\207\215 \n\024\032\ \036\021 \023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.264 Tw T* (\027\024\f\021\034 \023\024\f\035\036\007\031\033\013\017\b \035\017\027\ \017\005 \021\036\030\026\023\017\017 \023\030\036\023\026\030\026\021\026\ \n\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \n\036\b\026\027\017\n\026\n\017 \007\ \036\005\f\021\r\017\016;)Tj 0.01 Tc 0.141 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-126( )]TJ EMC 1.02 0 Td (\207\024\035\034\001\017\027\f\021\r\024 \023\026\006\017\036\027\021\024\ \r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \035\017\027\017\017 \002\017\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.151 Tw T* (\035\024\020\017\004\036\f\022\024\005 \021\036\030\026\023\017\017 \021\ \030\026\007\017\006\017\024\027\027\024 \023\024\035\031\004\026\033\021\ \030\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.26 Tw T* (\027\t\036 \017-\205\203\210-\256, \023\030\017\004\036\n \004\026\f\021\ \024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\021\036\030\036 \024\021\r\036\021\026)10( )]TJ 0.319 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\r\t\005 \017-\205\203\210-\256 \023\036\030\036\022\035\033\ \004\036\027\017\036 \023\030\024\017\f\b\024\007\017\021)10( )]TJ 0.121 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\007\030\031\020\024\005 \023\030\036\023\026\030\026\021 \021\024\020\024\ \032\036 \022\035\026\f\f\026, \004\021\024 \f\027\017\032\026\036\021)10( )]TJ 0.233 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \023\030\036\023\026\030\026\021\026\ \r\021\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc T* (\030\024\005 \035\017\027\017\017;)Tj 0 Tc -0.03 Tw -1.02 -1.218 Td (\232)Tj /Span<>> BDC [( )-297( )]TJ EMC 1 0 Td (\200\t\032\017\r\026\036\n\024\f\021\034 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \002\024\035\034\001\017\027\f\021\r\026 )Tj 0.045 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005, \f\024\023\024\f\021\026\r\017\ \n\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 \r\t)Tj 0 Tw (-)Tj T* (\032\017\r\026\036\n\024\f\021\034 \230\203\205 \r\t\001\036, \004\036\n\ \031)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (\206\210\214;)Tj 0.108 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-159( )]TJ EMC 1 0 Td [(\017-\205\203\210-\256 )0.6(\017\n\036\033\021 )0.5(\002\024\035\036\036 )0.5(\027\017\022\031\033 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034, )0.6(\004\036\n )]TJ -0.031 Tw T* (\200\213\212\210 \017)Tj /Span<>> BDC ( )Tj EMC (\211\225\224: \027\036 \002\024\035\036\036 2-\b \035\036\021 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\t \023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\254\025 \017)Tj /Span<>> BDC ( )Tj EMC (\207\025;)Tj -0.005 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-272( )]TJ EMC 1 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \023\030\036\023\026\030\026\021\026 2-\005\ \035\017\027\017\017 \027\026)Tj 0 Tw (-)Tj 0.02 Tw T* (\027\026\004\026\033\021 \200\213\212\210. \212\026\027\027\t\036 \024\002\ \220\235\235\036\022\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017)Tj 0 Tw (-)Tj -0.062 Tw T* [(\r\026\036\n\024\f\021\017 \200\213\212\210 )0.5(\r\024 2 )0.5(\035\017\027\017\017 \021\036\030\026\023\017\017 \023\030\024\021\017\r\ \024\030\036\004\017\r\t;)]TJ 0.029 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-238( )]TJ EMC 1 0 Td [(\200\213\212\210 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\230\203\205 )0.5(\024\002\035\026\007\026\033\021 \002\024\035\036\036 \r\t\f\024\022\024\ \005 )0.5(\r\t\032\017\r\026\036\n\024)]TJ 0 Tw (-)Tj 0.06 Tw T* (\f\021\034\033, \004\036\n \202\212\202 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\005 \017\035\017 )0.5(\r\021\024\030\024\005 \035\017\027\017\017 \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017)Tj 0 Tw (-)Tj T* (\036\027\021\024\r \200\003\025;)Tj -0.016 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-283( )]TJ EMC 1 0 Td (\211\225\224 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \007\036\n\024\ \027\f\021\030\017\030\031\036\021 \002\024\035\036\036 \r\t)Tj 0 Tw (-)Tj 0.063 Tw T* (\f\024\022\031\033 \r\t\032\017\r\026\036\n\024\f\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 \r\024 2-\005 )Tj 0 Tw T* (\035\017\027\017\017 \021\036\030\026\023\017\017 \023\024\f\035\036 \023\ \024\021\036\030\017 \024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210-\256;)Tj 0.359 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )92( )]TJ EMC 1 0 Td (\207\024\035\034\001\017\027\f\021\r\024 \017\f\f\035\036\007\024\r\026\027\ \017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \r\t\032\017\r\026)Tj 0 Tw (-)Tj 0.317 Tw T* (\036\n\024\f\021\017 \206\230\207\215 \027\036 \023\030\036\r\t\001\026\033\ \021 \024\007\027\024\020\024 \020\024\007\026, \035\017\001\034 )Tj 0.343 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034\022\017\b \017\f\f\035\036\007\024\r\026\027\017\ \016\b \024\006\036\027\017\r\026\036\021\f\016 \007\r\031\b- )Tj 0.054 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b\035\036\021\027\016\016 \r\t\032\017\r\026\036\n\024\f\021\ \034, \004\021\024 \027\036\007\024\f\021\026\021\024\004\027\024 \007\035\ \016 )Tj -0.009 Tw T* (\030\036\026\035\017\026\006\017\017 \007\024\035\020\024\f\030\024\004\ \027\t\b \006\036\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f\024 )Tj 0 Tw T* (\f\021\030\026\021\036\020\017\036\005 \2242\224;)Tj 0.027 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-240( )]TJ EMC 1 0 Td (\224\024\035\034\022\024 \007\035\016 \211\225\224 \023\024\022\026 \036\ \f\021\034 \007\024\035\020\024\f\030\024\004\027\t\036 $4 \017)Tj /Span<>> BDC ( )Tj EMC (5 \035\036\021$ )Tj 0.003 Tw T* (\007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 \023\030\026\022\021\017\ \004\036\f\022\017 \002\036 \023\024\021\036\030\017 )Tj 0 Tw T* (\024\021\r\036\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025;)Tj 0.017 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-250( )]TJ EMC 1 0 Td (\212\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \224\230\225 \017)Tj /Span<>> BDC ( )Tj EMC (\027\024\r\t\b \023\030\036\023\026\030\026\021\024\r )Tj 0.055 Tw T* (\022\035\026\f\f\026 \017\027\020\017\002\017\021\024\030\024\r \017\027\ \021\036\030\035\036\005\022\017\027\026 23 \023\024\022\026 \022\030\026\ \005\027\036 )Tj 0 Tw T* (\024\020\030\026\027\017\004\036\027\t;)Tj -0.001 Tw -1 -1.218 Td (\232)Tj /Span<>> BDC [( )-268( )]TJ EMC 1 0 Td (\211\004\017\021\t\r\026\016, \004\021\024 \r\021\024\030\017\004\027\026\ \016 \023\024\021\036\030\016 \024\021\r\036\021\026 \n\024\032\036\021 \ \002\t\021\034 )Tj 0.093 Tw T* (\f\r\016\026\027\026 \024\002\030\026\024\r\026\027\017\036\n \026\027\ \021\017\021\036\035 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\031, \006\036\035\036)Tj 0 Tw (-)Tj 0.135 Tw T* [(\f\024\024\002\030\026\027\024 \031\007\036\035\016\021\034 \r\027\017\n\ \026\027\017\036 )0.5(\035\036\022\026\030\f\021\r\036\027\027\024\n\031 \n\024)]TJ 0 Tw (-)Tj T* (\027\017\021\024\030\017\027\020\031, \004\021\024\002\t \024\023\021\017\ \n\017\017\030\024\r\026\021\034 \021\036\030\026\023\017\033.)Tj 0.077 Tw -1 -1.218 Td (\215\024 \027\026\001\036\n\031 \n\027\036\027\017\033, \031\022\026\026\ \027\027\t\036 \023\024\035\024\032\036\027\017\016 \n\024\020\031\021 \023\ \024)Tj 0 Tw (-)Tj 0.082 Tw T* (\n\024\004\034 \023\030\026\022\021\017\004\036\f\022\024\n\031 \r\030\026\ \004\031 \r\t\002\030\026\021\034 \023\036\030\r\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj T* (\007\031\033\013\017\036 \206\230\207\215 \002\024\035\036\036 \024\023\021\ \017\n\026\035\034\027\024.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 19.9277 56.0378 Tm (112)Tj ET endstream endobj 479 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 289.5098 42.7216 Tm [(Compar)21(ativ)12.1(e ef)-31(f)-21(icacy and sur)-21(viv)10(al of\022biologics in inflammator)-31(y bow)11(el )]TJ -0.033 -1 Td [(disease in dif)-30.9(fer)31(ent lines of\022th)11(er)21.1(apy: th)11(e\022clinician\226)63(s vie)11(w of\022th)11(e pr)20(oblem)]TJ -32.899 1 Td [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-10(\026\n \b\022\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-\b\t\235\f\t\f\017\t\240\002 )]TJ 0 -1 TD [(\210\b\025\013\025\020\b\213\f\205\007\b\002 \223\017\f\223\005\017\005\026\ )11(\025\016 $\031\030\214\034$ \223\017\b\022\016\025\205\223\005\013\b\026\ )11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 )]TJ T* [(\007\b\203\f\213\t\b\007\005 \016\022\017\005\001\t\240\002 \013\b\t\b\002\ \026)11(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-10(\013\b\t\b\216\b\205)-9.9(\026)11(\005 \t\005\022\223\017\025\210\013\f\024\220)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.034 Tw 10 0 0 10 42.5197 724.8299 Tm (2 \035\017\027\017\017 \021\036\030\026\023\017\017 \023\024\f\035\036 \023\ \024\021\036\030\017 \024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj -0.011 Tw 0 -1.218 TD (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036\027\017\017 \211\225\224 \007\024\f\021\017\020\ \026\035\017\f\034 \002\024\035\036\036 )Tj 0.033 Tw T* (\r\t\f\024\022\017\036 \023\024\022\026\026\021\036\035\017 \r\t\032\017\ \r\026\036\n\024\f\021\017 \021\036\030\026\023\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj 0.095 Tw T* [(\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\200\213\212\210 )0.5(\004\036\030\036 )0.5(52 \027\036\007\036\035\017 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\f\004\036\021 )0.5(\022\035\017\027\017\004\036\f\022\017\b )]TJ 0.1 Tw T* (\023\024\022\026\026\021\036\035\036\005, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026\f\021\024\021\026 \203\254 \017)Tj /Span<>> BDC ( )Tj EMC (\020\024\f\023\017\021\026\035\017\026\006\017\005 )Tj 0 Tw T* (\n\036\032\007\031 \023\030\036\023\026\030\026\021\026\n\017 \002\t\035\ \026 \f\024\023\024\f\021\026\r\017\n\026 [39].)Tj 0.387 Tw 0 -1.218 TD [(\230\f\f\035\036\007\024\r\026\027\017\036 ROT)35(AR)-13.9(Y \023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \030\036\ \021\030\024)]TJ 0 Tw (-)Tj 0.665 Tw 0 -1.218 TD (\f\023\036\022\021\017\r\027\024\036 \027\026\002\035\033\007\026\021\036\ \035\034\027\024\036 \022\024\020\024\030\021\027\024\036 \017\f\f\035\036\ \007\024)Tj 0 Tw (-)Tj 0.452 Tw T* [(\r\026\027\017\036, )0.5(\023\030\024\r\036\007\201\027\027\024\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 11.04 0 Td [(\024\f\027\024\r\036 )0.5(\007\026\027\027\t\b )0.6(\022\035\017\027\017\004\036)]TJ 0 Tw (-)Tj 0.091 Tw -11.04 -1.218 Td (\f\022\024\005 \002\026\t \007\026\027\027\t\b Optum \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (2012\2262020)Tj /Span<>> BDC ( )Tj EMC (\020\020. )Tj 0.437 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\ \004\036\027\024 4648)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.077 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025: 3008 \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (1640 \f)Tj /Span<>> BDC ( )Tj EMC (\254\025. \207\024\035\034\001\017\027\f\021\r\024 \023\026\006\017\036\027\ )Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD [(\021\024\r \023\024\035\031\004\026\035\017 )0.5(\017-\205\203\210 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\n\017 )0.5(\f\035\036\007\024\r\026\035\017 )0.5(\007\030\031\020\017\036 )]TJ 0.111 Tw 0 -1.218 TD (\017-\205\203\210 \017\035\017 \200\213\212\210. \200\213\212\210 \017)Tj /Span<>> BDC ( )Tj EMC (\230\203\205 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\ \017 )Tj 0.033 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.239 0 Td [(39,4% )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.493 0 Td [(34,6% )0.5(\002\024\035\036\036 )0.5(\027\017\022\017\036 )0.5(\023\024\022\026\026\021\036\035\017 )0.6(\023\036\030\036\022\035\033)]TJ 0 Tw (-)Tj 0.088 Tw -4.732 -1.218 Td [(\004\036\027\017\016 \017\035\017 \024\021\n\036\027\t, \004\036\n \202\212\ \202, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\022\026\004\036)Tj 0 Tw (-)Tj -0.013 Tw T* [(\f\021\r\036 )0.6(\206\230\207\215 )0.5(\023\036\030\r\024\005 )0.6(\035\017\027\017\017 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 11.019 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.198 0 Td [(\207\025, )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 2.256 0 Td [(\027\026 )0.6(30,8% )]TJ 0.085 Tw -18.473 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (34,3% \002\024\035\036\036 \027\017\022\017\036 \023\024\022\026\026\021\ \036\035\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\254\025. )Tj 0.043 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \206\230\207\215 \r\021\024\030\024\005 \035\ \017\027\017\017 \200\213\212\210, \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 \021\026\022)Tj 0 Tw (-)Tj 0.011 Tw T* (\032\036 \023\024\022\026\026\035\017 \002\024\035\036\036 \027\017\022\ \017\036 \023\024\022\026\026\021\036\035\017 \023\036\030\036\022\035\033\ \004\036\027\017\016 )Tj 0.173 Tw T* (\017\035\017 \024\021\n\036\027\t: 47,2%, 40,0% \017)Tj /Span<>> BDC ( )Tj EMC (43,5%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj -0.001 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\202\212\202 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\207\025, \017)Tj /Span<>> BDC ( )Tj EMC (56,5%, 43,0% )Tj 0.109 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (45,6% \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\254\025. \217\036\031\035\034\021\026\021\t \026\027\026\035\017\026 \ \023\030\024)Tj 0 Tw (-)Tj 0.093 Tw T* [(\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017, )0.6(\004\021\024 )0.5(\f\022\024\030\030\036\022\021\017\030\024\r\026\027\027\t\036 )0.6(\023\024\022\026\026\021\036)]TJ 0 Tw (-)Tj 0.018 Tw T* (\035\017 \024\021\n\036\027\t \007\035\016 \202\212\202 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \206\230\207\215 \023\036\030\r\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\005 )Tj 0.02 Tw T* (\035\017\027\017\017 \002\t\035\017 \r\t\001\036, \004\036\n \007\035\016\ \200\213\212\210, \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\211\225\224, \004\021\024 \023\024\007)Tj 0 Tw (-)Tj 0.151 Tw T* (\004\036\030\022\017\r\026\036\021 \r\026\032\027\024\f\021\034 \r\t\002\ \024\030\026 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 )Tj 0 Tw T* (\024\021 \022\035\017\027\017\004\036\f\022\024\005 \f\017\021\031\026\006\ \017\017 [40].)Tj 0.006 Tc 0.12 Tw T* [(\230\f\f\035\036\007\024\r\026\027\017\036 \211\027\017\r\036\030\f\017\021\ \036\021\f\022\024\005 \002\024\035\034\027\017\006\t \203\026\027\f\017\ \024\021)6( )]TJ 0.115 Tw T* (2023 \020\024\007\026 \002\t\035\024 \027\026\023\030\026\r\035\036\027\024\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 \r\t\032\017\r\026\036\n\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc -0.009 Tw T* (\f\021\017 \206\230\207-\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (4-\005 \017)Tj /Span<>> BDC ( )Tj EMC (5-\005 \035\017\027\017\016\b \035\036\004\036\027\017\016 \023\026\006\017\ \036\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.112 Tw T* (\021\024\r \200\003\025. \200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 \031\004\026\f\021\r\024\r\026\ \035\024 82 \023\026\006\017\036\027\021\026:)6( )]TJ 0.039 Tw T* (44)Tj /Span<>> BDC ( )Tj EMC (\004\036\035\024\r\036\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (4-\005 \035\017\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (38 \004\036\035\024\r\036\022)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC [(5-\005)6( )]TJ 0.104 Tw T* (\035\017\027\017\017. \206\030\031\023\023\t \002\t\035\017 \f\024\023\024\ \f\021\026\r\017\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\n \b\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.001 Tw T* (\030\026\022\021\036\030\017\f\021\017\022\026\n. \230\f\023\024\035\034\ \024\r\026\027\027\t\036 \023\030\036\023\026\030\026\021\t \r\022\035\033\ \004\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.014 Tw T* (\035\017 \030\017\026\027\022\017\031\n\026\002, \211\225\224 \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210. \206\030\031\023\023\t \002\t\035\017 \f\024\023\024\f\ \021\026)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.233 Tw T* [(\r\017\n\t. \215\030\036\023\026\030\026\021\t: \030\017\026\027\022\017\ \031\n\026\002, \031\f\021\036\022\017\027\031\n\026\002 \017\035\017)6( )]TJ 0.212 Tw T* (\r\036\007\024\035\017\031\n\026\002 \007\024\f\021\024\r\036\030\027\024\ \027\036 \024\021\035\017\004\026\035\017\f\034 $)Tj /T1_2 1 Tf 0 Tc 0 Tw (p)Tj /T1_1 1 Tf 0.006 Tc 0.212 Tw /Span<>> BDC 18.623 0 Td ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(0,05$)6( )]TJ 0.127 Tw -18.623 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (4-\005 \017)Tj /Span<>> BDC ( )Tj EMC (5-\005 \035\017\027\017\005. \200\t\032\017\r\026\036\n\024\f\021\034 \030\ \017)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.325 Tw T* (\026\027\022\017\031\n\026\002\026 \002\t\035\026 \f\026\n\024\005 \r\t\ \f\024\022\024\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\021\036\030\026\023\017\017 4-\005)6( )]TJ 0.165 Tw T* [(\035\017\027\017\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 4.916 0 Td [(\207\025: )0.5(\030\017\026\027\022\017\031\n\026\002 )0.5(36,0 )0.5(\027\036\007\036\035\034 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 14.942 0 Td (\f\030\026\r)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.114 Tw -19.858 -1.218 Td (\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\r\036\007\024\035\017\031\n\026\002\024\n 29,4 \027\036\007\036\035\017\ , \f\024\024\021\r\036\021\f\021\r\036\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc -0.006 Tw T* (\027\024, )Tj /T1_2 1 Tf 0 Tc 0 Tw 1.543 0 Td (\033)Tj /T1_1 1 Tf 0.006 Tc 0.09 Tw /Span<>> BDC 0.484 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008; \030\017\026\027\022\017\031\n\026\002 36,0 \027\036\007\036\035\ \034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.168 Tw -2.027 -1.218 Td (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\f\021\036\022\017\027\031\n\026\002\024\n 32,8 \027\036\007\036\035\ \017, \f\024\024\021\r\036\021\f\021\r\036\027\027\024,)6( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\033)Tj /T1_1 1 Tf 0.006 Tc -0.035 Tw /Span<>> BDC 0.484 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,035. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\017\b )0.5(\023\036\030\r\t\b \030\036\026\035\034\027\t\b )0.5(\031\f\035\024\r\017\016\b \030\017\026\027\022\017)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.103 Tw -0.484 -1.218 Td (\031\n\026\002 \r)Tj /Span<>> BDC ( )Tj EMC [(\022\026\004\036\f\021\r\036 \023\030\036\023\026\030\026\021\026 4-\005\ \035\017\027\017\017 \007\035\016 \035\036\004\036\027\017\016)6( )]TJ 0.137 Tw T* [(\200\003\025 )0.5(\n\024\032\036\021 )0.5(\017\n\036\021\034 )0.5(\002\024\035\036\036 )0.5(\007\035\017\021\036\035\034\027\031\033 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034,)6( )]TJ 0.267 Tw T* [(\004\036\n \007\030\031\020\017\036 \023\030\036\023\026\030\026\021\t. \ \200\t\032\017\r\026\036\n\024\f\021\034 \002\t\035\026 \r\t\001\036)6( )]TJ 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 [41].)Tj /T1_3 1 Tf 0 Tc 0 -2.436 TD (\034\214\214\210\b\002\n\r\b\b\002\217\003\001 \027\034\225\200)Tj /T1_1 1 Tf -0.019 Tw 0 -1.218 TD (\230\n\n\031\027\024\020\036\027\027\024\f\021\034 \024\023\030\036\007\036\ \035\016\036\021 \f\023\024\f\024\002\027\024\f\021\034 \023\030\036\023\ \026\030\026\021\024\r )Tj 0.115 Tw T* [(\r\t\t\r\026\021\034 )0.5(\017\n\n\031\027\027\t\005 )0.5(\024\021\r\036\021 \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\022\024\027\021\036\022\f\021\036 )Tj 0.044 Tw T* (\206\230\207\215 \220\021\024 \024\027\026\004\026\036\021, \004\021\024\ \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \023\026\006\017\036\027\021\024\r \n\024\ \020\031\021 )Tj 0.08 Tw 23.244 64.543 Td (\r\t\030\026\002\026\021\t\r\026\021\034\f\016 \026\027\021\017\021\036\035\ \026 \022)Tj /Span<>> BDC ( )Tj EMC [(\f\026\n\017\n \023\030\036\023\026\030\026\021\026\n $ant)-31.9(i-)]TJ 0.043 Tw T* [(dr)-22(ug ant)-32(ibodies, AD)20(A$, \022\024\021\024\030\t\036 \n\024\020\031\021 \027\036\005\021\030\026\ \035\017\024\r\026\021\034 )]TJ -0.07 Tw T* (\007\036\005\f\021\r\017\036 \206\230\207\215. \203\026\035\017\004\017\036\ \220\021\017\b \026\027\021\017\021\036\035 \n\024\032\036\021 \017\n\036\ \027\016\021\034 )Tj -0.037 Tw T* (\n\036\021\026\002\024\035\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\036\007\036\027\017\036 \023\030\036\023\026\030\026\021\026 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\017\n\026, \004\021\024 )Tj -0.032 Tw T* (\023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \022\024\027\006\036\027\021\030\026\006\017\ \017 \026\022\021\017\r\027\024\020\024 \r\036\013\036)Tj 0 Tw (-)Tj 0.071 Tw T* (\f\021\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 \017, \f\035\036\007\024\ \r\026\021\036\035\034\027\024, \f\027\017\032\036\027\017\033 )Tj 0.077 Tw 0 -1.218 TD (\036\020\024 \220\235\235\036\022\021\017\r\027\024\f\021\017. \215\026\006\ \017\036\027\021\t, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r\024\027\017\022\026\033\021 )Tj 0.389 Tw 0 -1.218 TD [(\021\026\022\017\036 \026\027\021\017\021\036\035\026, )0.5(\n\024\020\031\021 \007\036\n\024\027\f\021\030\017\030\024\r\026\021\034\ \f\027\017\032\036\027\017\036 )]TJ -0.026 Tw T* (\022\035\017\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\033, \031\r\036\035\017\004\036\027\017\036 \004\ \026\f\021\024\021\t )Tj 0.156 Tw T* [(\024\002\024\f\021\030\036\027\017\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.134 0 Td [(\027\036\024\002\b\024\007\017\n\024\f\021\034 )0.6(\f\n\036\027\t )0.5(\021\036\030\026\023\017\017. )0.6(\230-\026 )]TJ 0.247 Tw -6.134 -1.218 Td (\023\024\021\036\027\006\017\026\035\034\027\t\b \023\030\024\002\035\036\ \n \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\020\036\027\027\024\005 \030\036\026\022\006\017\036\ \005 )Tj 0.082 Tw T* (\023\026\006\017\036\027\021\t, \023\024\035\031\004\026\033\013\017\036\ \206\230\207\215, \n\024\020\031\021 \021\030\036\002\024\r\026\021\034\ \002\024\035\036\036 )Tj 0.272 Tw 0 -1.218 TD (\021\013\026\021\036\035\034\027\024\020\024 \n\024\027\017\021\024\030\017\ \027\020\026 \022\024\027\006\036\027\021\030\026\006\017\017 \023\030\036\ \023\026\030\026\021\026 )Tj 0.119 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC 0.87 0 Td [(\027\026\035\017\004\017\016 )0.6(\026\027\021\017-\035\036\022\026\030\f\021\r\036\027\027\t\b )0.6(\026\027\021\017\021\036\035 )0.5(\007\035\016 )0.5(\024\023\021\017\n\017)]TJ 0 Tw (-)Tj -0.87 -1.218 Td (\026\006\017\017 \035\036\004\036\027\017\016 [30,42,43].)Tj -0.028 Tw 0 -1.218 TD [(\230\f\f\035\036\007\024\r\026\021\036\035\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.568 0 Td [(\230\f\023\026\027\017\017 )0.5(\f\030\026\r\027\017\035\017 )0.5(\230\203\205 \017)]TJ /Span<>> BDC ( )Tj EMC 10.679 0 Td [(\202\212\202 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tw (-)Tj 0.071 Tw -18.247 -1.218 Td (\004\036\f\021\r\036 1 \017)Tj /Span<>> BDC ( )Tj EMC (2 \035\017\027\017\005 \021\036\030\026\023\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\031\004\017\035\017 \235\026\022\021\024)Tj 0 Tw (-)Tj 0.077 Tw T* (\030\t, \r\035\017\016\033\013\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017. \237\ \021\024 \030\036\021\030\024)Tj 0 Tw (-)Tj 0.081 Tw T* (\f\023\036\022\021\017\r\027\024\036 \024\007\027\024\006\036\027\021\030\ \024\r\024\036 \022\024\020\024\030\021\027\024\036 \017\f\f\035\036\007\ \024\r\026\027\017\036, )Tj -0.011 Tw T* (\r\022\035\033\004\026\r\001\036\036 \023\026\006\017\036\027\021\024\r \ \200\003\025, \023\024\035\031\004\026\r\001\017\b \206\230\207\215 \f)Tj /Span<>> BDC ( )Tj EMC (2008 )Tj 0.37 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (2017 \020\020. \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\035\034\027\024\005 \f\023\036\006\017\026\035\ \017\017\030\024\r\026\027\027\024\005 )Tj 0.074 Tw T* [(\002\024\035\034\027\017\006\036. )0.6(\204\036\007\017\026\027\026 )0.5(\027\026\002\035\033\007\036\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 13.817 0 Td [(\227 )0.5(52 )0.5(\n\036\f\016\006\026. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 6.986 0 Td (\017\f)Tj 0 Tw (-)Tj 0.105 Tw -20.803 -1.218 Td (\f\035\036\007\024\r\026\027\017\017 \031\004\026\f\021\r\024\r\026\035\017\ 134 \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 $73,9% )Tj 0.117 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (26,1% \f)Tj /Span<>> BDC ( )Tj EMC (\254\025$, \023\024\035\031\004\026\r\001\017\036 \206\230\207\215. \225\ \030\036\007\027\016\016 \r\t)Tj 0 Tw (-)Tj 0.227 Tw T* [(\032\017\r\026\036\n\024\f\021\034 )0.6(\007\035\016 )0.5(\202\212\202 )0.5(\f\024\f\021\026\r\017\035\026 )0.5(20,2 )0.5(\n\036\f\016\006\026, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 20.668 0 Td (\007\035\016 )Tj 0.029 Tw -20.668 -1.218 Td (\230\203\205)Tj /Span<>> BDC ( )Tj EMC 2.133 0 Td [(\227 )0.5(17,1 \n\036\f\016\006\026. )0.5(\200\t\032\017\r\026\036\n\024\f\021\034 )0.5(\r\024 )0.5(2 \035\017\027\017\017 )0.5(\021\036\030\026)]TJ 0 Tw (-)Tj 0.067 Tw -2.133 -1.218 Td (\023\017\017 \f\024\f\021\026\r\017\035\026 17,9 \n\036\f\016\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \202\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (12,5 \n\036\f\016)Tj 0 Tw (-)Tj 0.137 Tw T* (\006\026)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \230\203\205. \210\007\027\026\022\024 \030\026\027\017\ \006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \035\017\027\017\016\b \027\036 )Tj 0.079 Tw T* (\002\t\035\026 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024\005 $)Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.079 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,547 \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.079 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,676, )Tj 0.189 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024$. \224\036\030\026\023\ \036\r\021\017\004\036\f\022\017\005 \n\024\027\017\021\024\030\017\027\020\ \024\022\026)Tj 0 Tw (-)Tj 0.259 Tw T* (\026\035\f\016 \036\007\017\027\f\021\r\036\027\027\t\n \235\026\022\021\ \024\030\024\n, \f\r\016\026\027\027\t\n \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj -0.009 Tw T* (\001\036\005 \r\t\032\017\r\026\036\n\024\f\021\034\033 \r)Tj /Span<>> BDC ( )Tj EMC (1 $\210\221 0,27; 95% \212\230 0,15\2260,50$ )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\035\017\027\017\016\b $\210\221 0,26; 95% \212\230 0,10\2260,65$ [42]\ .)Tj 0.13 Tw T* (\217\036\021\030\024\f\023\036\022\021\017\r\027\t\005 \024\002\024\030\ \017\f\021\024\030\017\005 \002\024\035\036\027\017 376 \023\026\006\017\ )Tj 0 Tw (-)Tj 0.117 Tw T* (\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 \024\006\036\027\017\r\026\035 \r\035\017\016\027\017\036 \026\ \027\021\017\021\036\035 $\202\224$ \022)Tj /Span<>> BDC ( )Tj EMC (\206\230\207\215 )Tj 0.516 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017. )0.5(\215\036\030\r\017\004\027\024\005 \022\024\027\036\004\027\024\005 )]TJ 0.199 Tw T* (\021\024\004\022\024\005 \002\t\035\026 \r\t\032\017\r\026\036\n\024\f\021\ \034 \021\036\030\026\023\017\017 \017-\205\203\210 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036)Tj 0 Tw (-)Tj 0.097 Tw T* (\027\017\036 1)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026 \023\024\f\035\036 \017\n\036\030\036\027\017\016 \021\ \017\021\030\024\r \202\224 \022)Tj /Span<>> BDC ( )Tj EMC (\230\203\205 $\202\224\230$ )Tj 0.162 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 $\202\224\202$. \225\035\036\007\031\036\021 \024\021\n\036\ \021\017\021\034, \004\021\024 \027\017\022\017\036 \021\017\021\030\t \ )Tj 0.002 Tw T* (\202\224\202/\202\224\230 \f\024\f\021\026\r\035\016\033\021)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (200 \027\020/\n\035, \026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\036 \021\017\021\030\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.168 Tw T* (\202\224\202/\202\224\230)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (1000 \027\020/\n\035, \023\030\024\n\036\032\031\021\024\004\027\t\036 \021\ \017\021\030\t \202\224\202/)Tj 0.068 Tw T* (\202\224\230)Tj /Span<>> BDC ( )Tj EMC (\227 200\226999 \027\020/\n\035. \230)Tj /Span<>> BDC ( )Tj EMC (322 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n\017 )Tj 0.318 Tw T* (\021\017\021\030\026\n\017 271 \f\024\b\030\026\027\016\035\017 \017\f\b\ \024\007\027\031\033 \021\036\030\026\023\017\033 \017-\205\203\210 )Tj -0.02 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC 6.634 0 Td (9 \017)Tj /Span<>> BDC ( )Tj EMC 1.87 0 Td [(15 )0.5(\023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC 6.397 0 Td (\023\030\024\n\036\032\031\021\024\004\027\t\n\017 )Tj 0.11 Tw -14.9 -1.218 Td (\021\017\021\030\026\n\017 $)Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.11 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,026$ \017)Tj /Span<>> BDC ( )Tj EMC (1 \017)Tj /Span<>> BDC ( )Tj EMC (10 \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024)Tj 0 Tw (-)Tj 0.076 Tw T* (\022\017\n\017 \021\017\021\030\026\n\017 $)Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.076 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001$. \215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\031\021\024\004)Tj 0 Tw (-)Tj 0.066 Tw T* (\027\t\n\017 \021\017\021\030\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\036\005 \r\036\030\024\016\021\027\024\f\021\034\033\ \021\036\030\016\035\017 \024\021\r\036\021 )Tj -0.025 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210 \023\030\036\023\026\030\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\031\032\007\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\017 \017-\205\203\210 )Tj 0.044 Tw T* (\021\036\030\026\023\017\017, \004\036\n \023\026\006\017\036\027\021\t \ \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n\017 \021\017\021\030\026\n\017. \216\024\021\016 \030\ \026)Tj 0 Tw (-)Tj 0.106 Tw T* [(\n\036\030 )0.5(\r\t\002\024\030\022\017 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.23 0 Td [(\023\030\024\n\036\032\031\021\024\004\027\t\n\017 )0.6(\021\017\021\030\026\n\017 )]TJ 0.283 Tw -11.23 -1.218 Td (\002\t\035 \027\036\002\024\035\034\001\017\n, \022\035\017\027\017\006\017\ \f\021\026\n \f\035\036\007\031\036\021 \030\026\f\f\n\024\021\030\036\021\ \034 )Tj 0.004 Tw T* (\024\023\021\017\n\017\026\006\017\033 \007\024\t \017-\205\203\210 \023\ \030\036\023\026\030\026\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\024\002\026\r\035\036\027\017\036\n )Tj 0.045 Tw T* (\017\035\017 \002\036 \007\024\002\026\r\035\036\027\017\016 \230\225 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \023\030\024\n\036\032\031\021\024\004\027\t\ \b )Tj 0 Tw T* (\021\017\021\030\024\r [43].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 503.8146 56.0378 Tm (111)Tj ET endstream endobj 45 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 46 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 47 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 48 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 49 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 537 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.294 Tw 10 0 0 10 70.8661 724.8299 Tm (12)Tj /Span<>> BDC ( )Tj EMC (\n\036\f. \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\017 \211\225\224 \024\f\021\026\r\026\035\017\f\ \034 84,4% \023\030\024\021\017\r )Tj 0 Tw 0 -1.218 TD (61,5% \027\026)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 $P)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007$ [35].)Tj 0.178 Tw T* (\200 \026\r\f\021\030\026\035\017\005\f\022\024\005 \027\026\006\017\024\ \027\026\035\034\027\024\005 \022\024\020\024\030\021\036 \200\003\025 \030\ \036\021\030\024)Tj 0 Tw (-)Tj 0.39 Tw T* (\f\023\036\022\021\017\r\027\024 \024\006\036\027\017\r\026\035\017 \023\ \030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \035\036\004\ \036\027\017\016 )Tj 0.308 Tw T* ($\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017$ \ \202\212\202, \230\203\205, \200\213\212\210 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 )Tj 0.131 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\017 \032\036 \023\030\036\023\026\030\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\035\017\016\027\017\036 )Tj 0.013 Tw 0 -1.218 TD (\230\225 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036 \024\021\r\036\021\026 \022)Tj /Span<>> BDC ( )Tj EMC (\206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \035\017\027\017\016\b \035\036)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\004\036\027\017\016 [36]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\024 \r\022\035\033\ \004\036\027\024 2499)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.109 Tw T* [(\006\017\036\027\021\024\r, )0.5(\023\036\030\017\024\007 )0.6(\027\026\002\035\033\007\036\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 12.643 0 Td [(\227 )0.5(8219 )0.5(\004\036\035\024\r\036\022\024-\035\036\021. )]TJ 0.363 Tw -12.643 -1.218 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \007\r\031\b\035\036\021\027\016\016 \r\t\032\017\r\026\036\n\024\ \f\021\034 \024\022\026\026\035\026\f\034 \f\021\026)Tj 0 Tw (-)Tj 0.156 Tw T* (\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \f\026\n\024\ \005 \r\t\f\024\022\024\005 $)Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.156 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$ \007\035\016 )Tj 0.128 Tw T* (\211\225\224 $71,6% \002\024\035\034\027\t\b \023\030\024\007\024\035\032\ \026\035\017 \035\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.218 Tw 0 -1.218 TD (2 \035\036\021$ \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\230\203\205 $59,1%$, \202\212\202 $56,1%$, )Tj 0.155 Tw 0 -1.218 TD (\200\213\212\210 $51,4%$. \215\030\017)Tj /Span<>> BDC ( )Tj EMC 8.445 0 Td [(\f\030\036\007\027\036\021\016\032\036\035\024\n )0.5(\254\025 )0.5(\f\026\n\031\033 \r\t\f\024)]TJ 0 Tw (-)Tj 0.053 Tw -8.445 -1.218 Td (\022\031\033 \r\t\032\017\r\026\036\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 2 \035\036\021 \023\030\024\007\036\n\024\027\ \f\021\030\017\030\024)Tj 0 Tw (-)Tj 0.066 Tw 0 -1.218 TD (\r\026\035 \200\213\212\210 $61,7%, )Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.066 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$ \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\017\205\203\210-\256 )Tj 0.057 Tw T* ($\211\225\224 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 \027\036 \024\006\036\027\017\r\026\035\017$. \215\024\022\026\ \026\021\036\035\017 \r\t\032\017\r\026\036\n\024)Tj 0 Tw (-)Tj 0.048 Tw T* (\f\021\017 \007\035\016 \230\203\205 \f\024\f\021\026\r\017\035\017 47,4\ % \002\024\035\034\027\t\b, \026)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \202\212\202)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.238 Tw T* (34,7%, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \n\036\007\017\026\027\026 \r\t\032\017\r\026\036\n\024\f\ \021\017 \f\024\f\021\026\r\017\035\026 )Tj -0.019 Tw T* (21,6 \n\036\f. \017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\020\024 9 \n\036\f. \007\035\016 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202, \f\024\024\021\r\036\021\f\021\r\036\027)Tj 0 Tw (-)Tj 0.004 Tw T* (\027\024. \025\024\n\002\017\027\017\030\024\r\026\027\027\026\016 \021\036\ \030\026\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\021\017\024\023\031\030\017\027\026\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 )Tj 0.16 Tw T* (\023\024\r\t\f\017\035\026 \r\t\032\017\r\026\036\n\024\f\021\034 \017\205\ \203\210-\256 $)Tj /T1_1 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.16 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$, \027\024 \027\036 )Tj -0.013 Tw T* (\023\024\r\035\017\016\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \211\225\224 \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210. \203\026\035\017\004\017\036 \f\r\017)Tj 0 Tw (-)Tj 0.079 Tw T* (\013\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \007\024\f\021\024\r\036\030\027\024 \027\036 \r\035\017\016\035\ \024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 )Tj 0.319 Tw T* (\021\036\030\026\023\017\017 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202. \202\r\021\024\030\t \f\004\017\021\026\033\021 \235\026\022\ \021\024\030\026\n\017, )Tj 0.314 Tw T* [(\031\r\036\035\017\004\017\r\026\033\013\017\n\017 )0.6(\r\t\032\017\r\026\036\n\024\f\021\034 )0.5(\206\230\207\215, )0.6(\027\026\027\026\004\036\027\017\036 )]TJ 0.099 Tw T* (\023\030\036\023\026\030\026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \035\017\027\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \026\027\021\017-\205\203\210)Tj /Span<>> BDC ( )Tj EMC (\227 \036\013\036 )Tj 0 Tw T* (\022\024\n\002\017\027\026\006\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\230\225 [36].)Tj 0.27 Tw T* (\025\035\033\004\036\r\t\n \022\030\017\021\036\030\017\036\n \r\t\f\024\ \022\024\005 \r\t\032\017\r\026\036\n\024\f\021\017 \023\030\036)Tj 0 Tw (-)Tj 0.15 Tw T* [(\023\026\030\026\021\026 \f\035\031\032\017\021 )0.5(\036\020\024 \007\024\035\020\024\f\030\024\004\027\t\005 )0.5(\023\030\017\036\n )0.5(\002\036 \023\030\036\030\t)]TJ 0 Tw (-)Tj 0.077 Tw T* (\r\026\027\017\016 \021\036\030\026\023\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\005 \023\030\017\004\017\027\036. \225)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \021\024\004\022\017 \030\036)Tj 0 Tw (-)Tj 0.072 Tw T* (\027\017\016 \024\004\036\027\034 \023\024\022\026\026\021\036\035\034\027\ \t \007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (\254\025 )Tj 0.501 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\035\036\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\ \016\b. \215\030\024\035\024\027\020\017\030\024\r\026\027\027\024\036 )Tj 0.013 Tw T* [(\017\f\f\035\036\007\024\r\026\027\017\036 UNIFI L)75(TE \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\254\025 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\024\ )Tj 0.089 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \211\225\224 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 4 \035\036\021 )Tj -0.015 Tw T* ($200 \027\036\007\036\035\034$ \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \035\017\027\017\016\b \021\036\030\026\023\017\017 [3\ 7]. \224\026\022, \007\024\035\016 )Tj 0.072 Tw T* (\002\024\035\034\027\t\b, \023\030\024\007\024\035\032\017\r\001\017\b \035\ \036\004\036\027\017\036 \004\036\030\036 1, 2 \017)Tj /Span<>> BDC ( )Tj EMC (4 \020\024\007\026 )Tj 0.07 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\017\r\001\017\b \022\035\017\027\017\004\036\f\022\031\ \033 \030\036\n\017\f\f\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017)Tj 0 Tw (-)Tj -0.004 Tw T* (\004\036\f\022\024\036 \031\035\031\004\001\036\027\017\036, \027\036 \024\ \021\035\017\004\026\035\026\f\034 \024\021 \220\021\024\020\024 \023\024\ \022\026\026\021\036\035\016 )Tj 0.077 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\024\005 \022\024\027\036\004\027\024\005 \021\ \024\004\022\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (8-\005 \027\036\007\036\035\036 \035\036\004\036\027\017\016, )Tj 0.081 Tw T* ($\021.\036. \023\024\f\035\036 \021\024\004\022\017 \024\006\036\027\022\ \017 \030\036\031\035\034\021\026\021\024\r \017\027\007\031\022\006\017\ \017$ )Tj /T1_1 1 Tf 0 Tw (\005\027\030 )Tj T* (\025\022\034\020\037\022\036\020\032\001)Tj /T1_0 1 Tf 0.199 Tw ( \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 )Tj -0.047 Tw T* (\r\f\036\020\024 \023\036\030\017\024\007\026 \027\026\002\035\033\007\036\ \027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, 68\22670% $\007\036\035\034)Tj 0 Tw (-)Tj 0.087 Tw T* (\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\n\017 \006\017\235\030\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (8 \027\036\007\036\035\036 )Tj 0.095 Tw T* (\027\036 \002\024\035\036\036 2% \027\036\026\r\017\f\017\n\024 \024\021\ \030\036\032\017\n\026 \r\r\036\007\036\027\017\016 8 \017\035\017 )Tj 0.024 Tw T* (12 \027\036\007\036\035\034$. \212\035\016 )Tj /T1_1 1 Tf 0 Tw (\025\022\034\017\220\t\027\034\033\034\036)Tj /T1_0 1 Tf 0.024 Tw ( $\027\036 \024\021\r\036\021\004\017\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\205\203\210 )Tj 0.178 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036\027\017\016 \211\225\224$ \026\027\026\035\024\ \020\017\004\027\026\016 \022\026\030\021\017\027\026 \027\026\002\035\033\ \007\026)Tj 0 Tw (-)Tj 0.113 Tw T* (\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b \007\r\031\b \035\036\021\ , \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \007\024\035\016 \023\026\006\017)Tj 0 Tw (-)Tj -0.023 Tw T* (\036\027\021\024\r, \023\030\024\007\024\035\032\026\r\001\017\b \035\036\ \004\036\027\017\036 \023\024\f\021\036\023\036\027\027\024 \f\027\017\032\ \026\035\026\f\034 )Tj 0.233 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.984 0 Td [(\022 \022\024\027\006\031 4-\020\024 )0.5(\020\024\007\026 )0.5(\f\024\f\021\026\r\017\035\026 \024\022\024\035\024 )0.5(40% )0.5($\007\036\035\034\021\026 )]TJ 0.253 Tw -0.984 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\n\017 \006\017\235\030\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (8 \027\036\007\036\035\036 )Tj -0.027 Tw T* (10\22613% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \017\027\021\036\030\r\026\035\026\b \r\r\036\007\036\027\ \017\016$. \224\026\022\017\n \024\002)Tj 0 Tw (-)Tj 0.146 Tw T* (\030\026\024\n, \007\024\035\016 \002\024\035\034\027\t\b, \023\024\021\ \036\030\016\r\001\017\b \024\021\r\036\021, \007\024\f\021\026\021\024\004\ \027\024 )Tj -0.023 Tw T* [(\023\024\f\021\024\016\027\027\026 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.668 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.6(\r\f\036\020\024 )0.5(\023\036\030\017\024\007\026 )0.5(\027\026\002\035\033\007\036\027\017\016 )]TJ 0.033 Tw 17.576 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\036\002\035\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\024\n \017\027\021\036\030\r\026\035\036, \023\ \030\017\004\036\n \030\026\027\017)Tj 0 Tw (-)Tj -0.022 Tw T* (\006\026 \n\036\032\007\031 \002\017\024\027\026\017\r\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\021\r\036\021\004\017\022\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210 \027\036 )Tj 0 Tw T* (\027\026\004\017\021\036\035\034\027\026.)Tj -0.038 Tw T* (\225\b\024\007\027\024\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\005\027\031 \023\030\024\035\024\027\020\017\030\024\r\026\ \027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.002 Tw T* [(IM-UNITI L)75(TE \024\006\036\027\017\r\026\035\024 \r\t\032\017\r\026\036\n\024\f\021\ \034 \211\225\224 \031)]TJ /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.101 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 5 \035\036\021 $252 \027\036\007\036\035\017\ $ \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \035\017)Tj 0 Tw (-)Tj 0.075 Tw 0 -1.218 TD (\027\017\016\b \021\036\030\026\023\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\027\026\017\r\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\235\220\005\035\024\030\024\r [38]. )Tj 0.127 Tw 0 -1.218 TD (\203\026)Tj /Span<>> BDC ( )Tj EMC (44)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\036 \027\026\002\035\033\007\036\027\017\016 $\024\ \007\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\036\004\027\t\b \021\024\004\036\022 )Tj 0.115 Tw T* (\217\025\230 IM-UNITI)Tj /Span<>> BDC ( )Tj EMC (\227 \023\036\030\r\026\016 \021\024\004\022\026 \024\006\036\027\022\017\ \023\024\007\007\036\030\032\017\r\026)Tj 0 Tw (-)Tj -0.002 Tw T* (\033\013\036\005 \021\036\030\026\023\017\017$ \007\024\035\016 \002\024\ \035\034\027\t\b, \007\024\f\021\017\020\001\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\017\r)Tj 0 Tw (-)Tj 0.21 Tw T* (\001\017\b \022\035\017\027\017\004\036\f\022\017\005 \024\021\r\036\021\ /\030\036\n\017\f\f\017\033 \f\024\f\021\026\r\017\035\026 \024\022\024\035\ \024 )Tj 0.321 Tw T* (80% \007\035\016 \002\017\024\027\026\017\r\027\t\b \023\026\006\017\036\ \027\021\024\r, \f\027\017\032\026\016\f\034 \023\024\f\021\036)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD [(\023\036\027\027\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.685 0 Td [(\007\024\f\021\017\020\027\031\r )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 5.268 0 Td [(252 )0.5(\027\036\007\036\035\036 )0.5(47% \017)]TJ /Span<>> BDC ( )Tj EMC 8.013 0 Td [(55% )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\026\r\017)Tj 0 Tw (-)Tj 0.128 Tw -16.966 -1.218 Td [(\f\017\n\024\f\021\017 )0.5(\024\021 \030\036\032\017\n\026 \r\r\036\007\036\027\017\016 )0.5($\007\036\035\034\021\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.139 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (44 \027\036\007\036\035\036\005 \007\035\016 8-\027\036\007\036\035\034\027\ \024\020\024 \017\027\021\036\030\r\026\035\026 25%, \007\035\016 )Tj -0.019 Tw T* (12-\027\036\007\036\035\034\027\024\020\024 \017\027\021\036\030\r\026\035\ \026 36%$. \225\030\036\007\017 \002\017\024\027\036\027\026\017\r\027\t\ \b )Tj 0.035 Tw T* (\023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (44 \027\036\007\036\035\036 \f\024\b\030\026\027\017\035\017 \024\021\r\036\ \021 63% \017)Tj /Span<>> BDC ( )Tj EMC (57%, )Tj 0.088 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\027\026 252 \027\036\007\036\035\036 35 \017)Tj /Span<>> BDC ( )Tj EMC (36% $\007\036\035\034\021\026 22% \017)Tj /Span<>> BDC ( )Tj EMC (26%, \f\024\024\021)Tj 0 Tw (-)Tj 0.032 Tw T* (\r\036\021\f\021\r\036\027\027\024$. \225\035\036\007\031\036\021 \024\021\ \n\036\021\017\021\034, \004\021\024 \007\035\016 \207\025 \021\036\027\007\ \036\027\006\017\016 )Tj 0.086 Tw T* (\002\t\035\026 \026\027\026\035\024\020\017\004\027\026 \254\025, \027\024\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \f\027\017\032\036\027\017\036 \r\t\032\017\r\026\036)Tj 0 Tw (-)Tj 0.089 Tw T* (\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 \002\t\035\024 \002\024\ \035\034\001\036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \f\031)Tj 0 Tw (-)Tj 0.118 Tw T* (\013\036\f\021\r\036\027\027\024\005, \027\024 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\036 \027\026\004\017\n\024\005 \030\026\027\017\ \006\036 )Tj 0.162 Tw T* (\n\036\032\007\031 \002\017\024\027\026\017\r\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\235\220\005\035\024\030\026\n\017. \224\026\022\017\n \024\002\ \030\026)Tj 0 Tw (-)Tj -0.027 Tw T* (\024\n, \211\225\224 \007\036\n\024\027\f\021\030\017\030\031\036\021 \007\ \024\f\021\026\021\024\004\027\024 \r\t\f\024\022\031\033 \r\t\032\017\r\ \026)Tj 0 Tw (-)Tj 0.028 Tw T* (\036\n\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036 \220\235\235\036\022\021\017\r\027\024\ \f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\024\f\030\024\004\027\024\005 )Tj 0.267 Tw T* [(\023\036\030\f\023\036\022\021\017\r\036 )0.5(4\2265)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\021 \007\035\016 )0.5(\200\003\025, \024\f\024\002\036\027\027\024 )0.5(\026\n\036\021\027\031\033 )]TJ 0.009 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025, \004\021\024 \f\024\024\021\r\036\021\f\021\r\031\036\021 \006\ \036\035\016\n \017)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\002\024\r\026\027\017\016\n \f\021\030\026)Tj 0 Tw (-)Tj T* (\021\036\020\017\017 \2242\224 [3].)Tj 0.283 Tw T* [(\254\023\024\027\f\022\024\036 )0.5(\027\026\006\017\024\027\026\035\034\027\024\036 )0.5(\030\036\021\030\024\f\023\036\022\021\017\r\027\024\036 )0.5(\017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj 0.125 Tw T* (\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\036\027\017\036\n 1942 \023\026\006\017\036\027\021\024\ \r \254\025 \017)Tj /Span<>> BDC ( )Tj EMC (1115 \023\026)Tj 0 Tw (-)Tj 0.294 Tw T* [(\006\017\036\027\021\024\r \207\025 \030\026\f\f\n\026\021\030\017\r\026\ \035\024 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017 )]TJ 0.097 Tw T* (\030\026\027\t\n\017 \022\035\026\f\f\026\n\017 \206\230\207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\224\230\225 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 2 \035\036\021. \212\035\016 )Tj 0.107 Tw T* [(\207\025 \r\t\032\017\r\026\036\n\024\f\021\034 )0.5(\211\225\224, \024\006\036\027\036\027\027\026\016 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\035\017\004\036\f\021\r\031 )0.5(\023\026)]TJ 0 Tw (-)Tj -0.044 Tw T* (\006\017\036\027\021\024\r, \024\f\021\026\r\001\017\b\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017, \002\t\035\026 \f\026\n\024\005 \r\t\f\024\ \022\024\005 )Tj 0.032 Tw T* (\r\024 \r\f\036 \023\036\030\017\024\007\t \027\026\002\035\033\007\036\027\ \017\016 $94,7%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 6)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016)Tj 0 Tw (-)Tj -0.038 Tw T* (\006\036\r, 91,3%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 12)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r, 88,2%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 18)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.168 Tw T* [(\f\016\006\036\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.677 0 Td (80,4%)Tj /Span<>> BDC ( )Tj EMC 2.844 0 Td [(\227 )0.5(\004\036\030\036 )0.6(24 )0.5(\n\036\f\016\006\026$. )0.5(\200\t\032\017\r\026\036\n\024\f\021\034 )]TJ -0.017 Tw -6.521 -1.218 Td (\017\205\203\210 $\230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202$ \002\t\035\026 \027\036\f\022\024\035\034\022\024 \027\017\ \032\036, \027\024 \f\024\023\024\f\021\026)Tj 0 Tw (-)Tj 0.065 Tw T* (\r\017\n\026 \f)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\036\002\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\026\035\036 84\22687%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036)Tj 0 Tw (-)Tj 0.042 Tw T* (\030\036 \020\024\007 \017)Tj /Span<>> BDC ( )Tj EMC (76%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 2)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026. \225\026\n\024\005 \027\017\022\024\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 )Tj 0.315 Tw T* (\024\022\026\026\035\026\f\034 \r\t\032\017\r\026\036\n\024\f\021\034 \200\ \213\212\210, \022\024\021\024\030\026\016 \f\024\f\021\026\r\017\035\026\ )Tj 0.017 Tw T* (\004\036\030\036 1)Tj /Span<>> BDC ( )Tj EMC (\020\024\007)Tj /Span<>> BDC ( )Tj EMC (\227 53%, \026)Tj /Span<>> BDC ( )Tj EMC (\004\036\030\036 2)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\f\036\020\024 28%. \212\035\016 )Tj 0.127 Tw T* (\022\024\020\024\030\021\t \254\025 \f\026\n\026\016 \r\t\f\024\022\026\016\ \r\t\032\017\r\026\036\n\024\f\021\034 \021\026\022\032\036 \024\021)Tj 0 Tw (-)Tj -0.014 Tw T* (\n\036\004\036\027\026 \007\035\016 \211\225\224 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 \r\f\036\b \023\036\030\017\024\ \007\024\r \027\026\002\035\033)Tj 0 Tw (-)Tj 0.219 Tw T* (\007\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\n \f\027\017\032\036\027\017\036\n: 9\ 5,1%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 )Tj 0.094 Tw T* (6)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(\n\036\f\016\006\036\r, )0.5(84,0%)]TJ /Span<>> BDC ( )Tj EMC 6.678 0 Td [(\227 )0.5(\004\036\030\036 )0.6(12)]TJ /Span<>> BDC ( )Tj EMC [(\n\036\f\016\006\036\r, )0.6(81,6%)]TJ /Span<>> BDC ( )Tj EMC 11.99 0 Td [(\227 )0.5(\004\036)]TJ 0 Tw (-)Tj 0.099 Tw -19.495 -1.218 Td (\030\036 18)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \017)Tj /Span<>> BDC ( )Tj EMC (75,0%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 24)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\026. \212\036\035\034\021\026 )Tj 0.159 Tw T* [(\007\035\016 )0.5(\002\024\035\034\027\t\b, )0.6(\023\030\036\022\030\026\021\017\r\001\017\b )0.6(\023\030\017\036\n )0.5(\023\030\036\023\026\030\026\021\026 )0.5(\004\036\030\036 )]TJ 0.046 Tw T* (2 \020\024\007\026, \f\024\f\021\026\r\017\035\026 20%. \200\t\032\017\r\ \026\036\n\024\f\021\034 \021\024\235\026\006\017\021\017\027\017\002\026\ )Tj -0.051 Tw T* [(\004\036\030\036 2 \020\024\007\026 \027\036 \023\030\036\r\t\001\026\035\ \026 \r\t\032\017\r\026\036\n\024\f\021\017 )0.5(\r\f\036\b \017-\205\203\210 )]TJ -0.013 Tw T* ($\230\203\205, \202\212\202, \206\210\214$ \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 \007\035\016 \r\f\036\b \031\022\026\026\ \027\027\t\b \023\030\036)Tj 0 Tw (-)Tj 0.167 Tw T* [(\023\026\030\026\021\024\r, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\036\007\027\036\n, )0.5(43\22648%. \200\213\212\210 )0.5(\026\027\016\035 )0.5(\023\030\024\n\036\032\031)]TJ 0 Tw (-)Tj 0.077 Tw T* (\021\024\004\027\031\033 \023\024\017\006\017\033 \n\036\032\007\031 \211\ \225\224 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \023\030\036\023\026\030\026\021\026\n\017.)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.009 Tw T* (\224\026\022\032\036 \002\t\035\024 \023\024\022\026\026\027\024 \023\030\ \036\017\n\031\013\036\f\021\r\024 \211\225\224 \027\026\007 \200\213\212\ \210 \r\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 19.9277 56.0378 Tm (110)Tj ET endstream endobj 536 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 289.5098 42.7216 Tm [(Compar)21(ativ)12.1(e ef)-31(f)-21(icacy and sur)-21(viv)10(al of\022biologics in inflammator)-31(y bow)11(el )]TJ -0.033 -1 Td [(disease in dif)-30.9(fer)31(ent lines of\022th)11(er)21.1(apy: th)11(e\022clinician\226)63(s vie)11(w of\022th)11(e pr)20(oblem)]TJ -32.899 1 Td [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-10(\026\n \b\022\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-\b\t\235\f\t\f\017\t\240\002 )]TJ 0 -1 TD [(\210\b\025\013\025\020\b\213\f\205\007\b\002 \223\017\f\223\005\017\005\026\ )11(\025\016 $\031\030\214\034$ \223\017\b\022\016\025\205\223\005\013\b\026\ )11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 )]TJ T* [(\007\b\203\f\213\t\b\007\005 \016\022\017\005\001\t\240\002 \013\b\t\b\002\ \026)11(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-10(\013\b\t\b\216\b\205)-9.9(\026)11(\005 \t\005\022\223\017\025\210\013\f\024\220)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.357 Tw 10 0 0 10 42.5197 724.8299 Tm [($71/81, 89%$, )0.5(\004\036\n \031)]TJ /Span<>> BDC ( )Tj EMC [(\002\024\035\034\027\t\b, )0.5(\023\024\035\031\004\026\r\001\017\b )0.5(\017-\205\203\210 )]TJ 0.177 Tw 0 -1.218 TD (\023\024\f\035\036 \200\213\212\210 $15/34, 44%; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.177 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0001$. \224\024\004\027\024 \021\026\022\032\036 )Tj 0.253 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \f\021\026\021\017\f\021\017\004\036\f\022\024\005\ \007\024\f\021\024\r\036\030\027\024\f\021\034\033 \024\021\035\017\004\ \026)Tj 0 Tw (-)Tj 0.136 Tw T* (\035\017\f\034 \007\030\031\020\017\036 \022\030\017\021\036\030\017\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \200\213\212\210 \r\024 2-\005 \035\017\027\017\017\ : )Tj 0.109 Tw T* (\004\026\f\021\024\021\026 \002\036\f\f\021\036\030\024\017\007\027\024\005\ \030\036\n\017\f\f\017\017, \007\024\035\016 \002\024\035\034\027\t\b, \ \017)Tj 0 Tw (-)Tj 0.047 Tw T* [(\002\036\032\026\r\001\017\b )0.6(\022\024\035\220\022\021\024\n\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.384 0 Td [(\020\024\f\023\017\021\026\035\017\026\006\017\005. )0.6(\210\007\027\026\022\024 )0.5(\026\r)]TJ 0 Tw (-)Tj 0.094 Tw -10.384 -1.218 Td (\021\024\030\t \024\021\n\036\004\026\033\021, \004\021\024 \007\026\027\ \027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \017\n\036\035\024\ \030\016\007 )Tj 0.33 Tw T* (\024\020\030\026\027\017\004\036\027\017\005, \023\030\017\f\031\013\017\ \b \007\017\026\005\027\031 \030\036\021\030\024\f\023\036\022\021\017\r\ \027\024\020\024 )Tj 0.09 Tw T* (\n\027\024\020\024\006\036\027\021\030\024\r\024\020\024 \017\f\f\035\036\ \007\024\r\026\027\017\016. \215\030\024\021\024\022\024\035\t \035\036\004\ \036\027\017\016 )Tj -0.007 Tw T* (\027\036 \002\t\035\017 \f\021\026\027\007\026\030\021\017\017\030\024\r\ \026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\020\035\017 \n\036\027\016\021\034\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036)Tj 0 Tw (-)Tj -0.007 Tw T* (\027\017\036\n \r\030\036\n\036\027\017. \215\024\022\026\026\021\036\035\ \017 \017\f\b\024\007\024\r \021\036\030\026\023\017\017 \021\026\022\032\ \036 \027\036 )Tj 0.151 Tw T* (\002\t\035\017 \f\021\026\027\007\026\030\021\017\017\030\024\r\026\027\ \t, \r\022\035\033\004\026\016 \024\021\f\031\021\f\021\r\017\036 \026\030\ \026)Tj 0 Tw (-)Tj 0.124 Tw 0 -1.218 TD [(\027\036\036 \031\f\021\026\027\024\r\035\036\027\027\024\005 \220\027\007\ \024\f\022\024\023\017\004\036\f\022\024\005 )0.5(\024\006\036\027\022\017, \023\024\220\021\024)]TJ 0 Tw (-)Tj 0.06 Tw 0 -1.218 TD (\n\031 \024\007\027\024\027\026\004\027\024 \020\024\r\024\030\017\021\034\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\030\017\021\036\021\027\024\f\021\017 \200\213\212\210 \ \027\026\007 )Tj 0 Tw 0 -1.218 TD (\017-\205\203\210, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \026\r\021\024\030\024\r, \023\024\022\026 \030\026\ \027\024 [27].)Tj 0.224 Tw T* (\025\030\026\005\027\036 \r\026\032\027\t\n \002\t\035\024 \023\030\016\n\ \024\036 \f\030\026\r\027\036\027\017\036 $\017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.144 Tw T* [(\r\026\027\017\036 SEA)36(VUE$, \027\036 \023\024\022\026\026\r\001\036\036 \030\026\035\017\004\ \017\005 \n\036\032\007\031 \211\225\224 )]TJ -0.007 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\207\025 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 )0.5(\022\024\027\036\004\027\t\b )0.5(\021\024\004\036\022 )0.5($\022\035\017\027\017\004\036)]TJ 0 Tw (-)Tj 0.044 Tw T* (\f\022\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\n\017\f\ \f\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (52 \027\036\007\036\035\036$, \004\021\024 )Tj 0.076 Tw T* (\f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\t\b \r\024\n\024\032\027\024\f\021\016\b \023\030\036\023\ \026\030\026\021\024\r )Tj 0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \035\017\027\017\017 \021\036\030\026\023\017\017\ . \210\007\027\026\022\024 \004\026\f\021\024\021\026 \024\021\n\036\027\ \t \202\212\202 )Tj 0.197 Tw T* (\017-\026 \203\254 \004\036\030\036 1 \020\024\007 \002\t\035\026 \024\ \021\n\036\004\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\024\r\036\030\027\024 )Tj 0.113 Tw T* [(\002\024\035\034\001\036\020\024 )0.6(\022\024\035\017\004\036\f\021\r\026 )0.5(\002\024\035\034\027\t\b )0.6($23,6% )0.5(\023\030\024\021\017\r )0.6(15,2%, )]TJ 0.122 Tw T* [(\023\024\035\031\004\026\r\001\017\b )0.6(\211\225\224, )]TJ /T1_2 1 Tf 0 Tw 7.276 0 Td (\033)Tj /T1_1 1 Tf 0.122 Tw /Span<>> BDC ( )Tj EMC 0.832 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.855 0 Td [(0,047$. )0.5(\237\021\024 )0.5(\023\024\r\024\035\016\036\021 )0.6(\020\024\r\024\030\017\021\034 )]TJ 0.284 Tw -8.963 -1.218 Td (\024)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\024\005 \r\t\032\017\r\026\036\n\024\ \f\021\017 \211\225\224 \022\026\022 \n\017\027\017\n\031\n )Tj 0.068 Tw T* (\004\036\030\036 1 \020\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \002\036\024\023\026\f\027\024\ \f\021\017 \017, \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.062 Tw T* (\f\021\r\036\027\027\024, \024)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\036\026\035\034\027\024\n \023\030\036\017\n\031\013\036\ \f\021\r\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \017\027\021\036\030)Tj 0 Tw (-)Tj T* (\r\026\035 \r\030\036\n\036\027\017 [28].)Tj 0.26 Tw T* [(\200\t\002\024\030 \206\230\207\215 )0.5(\007\035\016 2-\005 \035\017\027\017\017 )0.5(\021\036\030\026\023\017\017 )0.5(\021\036\024\030\036\021\017\004\036\f\022\017 )]TJ 0.474 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021\f\016 \002\024\035\036\036 \ \f\035\024\032\027\t\n, \023\024\f\022\024\035\034\022\031 \002\024\035\034\ )Tj 0 Tw (-)Tj 0.122 Tw T* (\001\017\027\f\021\r\024 \022\035\017\027\017\004\036\f\022\017\b \030\036\ \022\024\n\036\027\007\026\006\017\005 \031\022\026\t\r\026\033\021, \004\ \021\024 )Tj 0.004 Tw T* (\022\026\032\007\t\005 \f\035\036\007\031\033\013\017\005 \023\030\036\023\ \026\030\026\021 \n\036\027\036\036 \220\235\235\036\022\021\017\r\036\027\ , \004\036\n )Tj 0.259 Tw T* (\023\030\036\007\t\007\031\013\017\005 [6,7,8,29]. \203\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\022\036 \220\021\024 \027\036 \r\f\036\020\007\026\ )Tj 0.174 Tw T* (\023\024\007\021\r\036\030\032\007\026\036\021\f\016. \225\030\026\r\027\ \036\027\017\017 \202\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 \r\024 \r\021\024\030\024\005 )Tj 0.209 Tw T* [(\035\017\027\017\017 \002\t\035\024 \023\030\024\r\036\007\036\027\024 F\ )20(av)-15(ale A. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \022\024\021\024\030\t\036 )Tj 0.273 Tw T* [(\023\024\022\026\026\035\017 )0.6(\002\024\035\036\036 )0.5(\r\t\f\024\022\031\033 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 18.83 0 Td (\021\036\004\036\027\017\036 )Tj 0.008 Tw -18.83 -1.218 Td (52 \027\036\007\036\035\034 \007\035\016 \200\213\212\210 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (A\212A \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.128 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\254\025, \023\024\021\036\030\016\r\001\017\b \024\021\r\036\021 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\230\203\205 $\004\026\f\021\024\021\026 \023\030\036\022\030\026\013\036\ )Tj 0 Tw (-)Tj 0.085 Tw T* (\027\017\016 \021\036\030\026\023\017\017 22,4% \007\035\016 \200\213\212\ \210 \023\030\024\021\017\r 48,0% \007\035\016 A\212A, )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035$ [30].)Tj 0.438 Tw T* [(\203\026\006\017\024\027\026\035\034\027\024\036 )0.6(\001\r\036\007\f\022\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\023\030\024\007\036\n\024\027)]TJ 0 Tw (-)Tj 0.183 Tw T* (\f\021\030\017\030\024\r\026\035\024 \023\030\024\021\017\r\024\023\024\035\ \024\032\027\t\005 \030\036\031\035\034\021\026\021: \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.12 Tw T* (\021\024\r, \030\026\027\036\036 \023\024\035\031\004\026\r\001\017\b \035\ \036\004\036\027\017\036 \017-\205\203\210-\256 \r)Tj /Span<>> BDC ( )Tj EMC (1 \035\017\027\017\017, )Tj 0.127 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\026\023\017\017 \200\ \213\212\210 \002\t\035\026 \027\017\032\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.047 Tw T* (\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \017-\205\203\210-\256 \r\024 2 \035\017\027\017\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \020\024\007\026 )Tj 0.086 Tw T* (\022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \207\025. \212\035\016 \207\025 \r\t\032\017\r\026\036\n\024\ \f\021\034 \f\024)Tj 0 Tw (-)Tj 0.079 Tw T* (\f\021\026\r\017\035\026 73% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \200\213\212\210 \023\030\024\021\017\r 74%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.246 Tw T* (\017-\205\203\210 $\212\230: \26211\22613; P)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,87$. \200\t\032\017\r\026\036\n\024\f\021\034 \002\036 )Tj 0.05 Tw T* (\020\024\f\023\017\021\026\035\017\026\006\017\017, \f\r\016\026\027\027\ \024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 $82% \023\030\024\021\017\r 88%$, )Tj 0.299 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\ \036\035\034\f\021\r\026 $82% \023\030\024\021\017\r 89%$, )Tj 0.384 Tw T* (\026\027\021\017\002\017\024\021\017\022\024\r $65% \023\030\024\021\017\ \r 71%$, \020\024\f\023\017\021\026\035\017\026\006\017\017 )Tj 0.125 Tw T* [(\017-\026 )0.5(\017\027\235\036\022\006\017\017 )0.5($95% \023\030\024\021\017\r 88%$ )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\030\021\017\022\024\f\021\036\030\024)Tj 0 Tw (-)Tj 0.215 Tw T* (\017\007\024\r $58% \023\030\024\021\017\r 48%$ \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\024 \027\036 )Tj 0.068 Tw T* [(\030\026\035\017\004\026\035\026\f\034 )0.6(\n\036\032\007\031 )0.5(\020\030\031\023\023\026\n\017. )0.5(\212\035\016 )0.6(\254\025 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )]TJ 0.049 Tw 23.244 64.543 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\036\n\036 \023\030\036\023\026\030\026\021\026 \f\024\f\021\ \026\r\017\035\026 69% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \200\213\212\210 )Tj 0.214 Tw T* (\023\030\024\021\017\r 62%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017-\205\203\210 $\212\230: \024\021 \26220 \007\ \024)Tj /Span<>> BDC ( )Tj EMC (6; )Tj 0.034 Tw T* (P)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,30$. \215\026\006\017\036\027\021\t, \023\024\035\031\004\026\r\001\017\ \036 \035\036\004\036\027\017\036 \200\213\212\210, \017\n\036)Tj 0 Tw (-)Tj 0.064 Tw T* (\035\017 \002\024\035\036\036 \027\017\022\031\033 \r\t\032\017\r\026\036\ \n\024\f\021\034 \002\036 \020\024\f\023\017\021\026\035\017\026\006\017\ \017, )Tj 0.026 Tw T* (\f\r\016\026\027\027\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 $82% \023\030\024\021\017\r 93%, P)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02$. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\031)Tj 0 Tw (-)Tj 0.031 Tw T* (\020\017\n \023\024\022\026\026\021\036\035\016\n $\004\026\f\021\024\021\ \036 \017\027\235\036\022\006\017\005, \020\024\f\023\017\021\026\035\017\ \026\006\017\005 )Tj 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\007\030.$ \023\030\036\023\026\030\026\021\t \002\t\035\017 \f\030\026\ \r\027\017\n\t [31].)Tj -0.001 Tw 0 -1.218 TD (\212\026\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\203\024\030\r\036\032\f\022\024\020\024 \030\036\036\f\021\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\024\n 2444)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.08 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017\ , \004\021\024 \004\036\030\036 3 \020\024\007\026 )Tj 0.209 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\034 \230\203\205 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \035\017\027\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 )Tj 0.03 Tw T* (\002\t\035\026 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 \r\t\001\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 $50,3% )Tj 0.058 Tw T* (\023\030\024\021\017\r 40,5%, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$. \212\035\016 \021\036\030\026\023\017\017 2-\005 \035\017\027\017\ \017 \023\024)Tj 0 Tw (-)Tj 0.037 Tw 0 -1.218 TD (\022\026\026\021\036\035\017 \r\t\032\017\r\026\036\n\024\f\021\017 \007\ \035\016 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \002\t\035\017 \024\007\017\027\026)Tj 0 Tw (-)Tj 0.146 Tw 0 -1.218 TD (\022\024\r\t $42,4% \017)Tj /Span<>> BDC ( )Tj EMC (42,8%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024$, \027\024 \002\ \t\035\017 \007\024)Tj 0 Tw (-)Tj 0.14 Tw 0 -1.218 TD (\f\021\024\r\036\030\027\024 \r\t\001\036 \007\035\016 \200\213\212\210 \ $69,8%, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.14 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$. \200\026\032\027\024 )Tj 0.111 Tw T* (\024\021\n\036\021\017\021\034, \004\021\024 \200\213\212\210 \027\036 \027\ \026\027\026\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \206\230\207\215 )Tj -0.043 Tw T* (1-\005 \035\017\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\203\024\030\r\036\020\017\017 \017-\026 \024\f\024\002\036\027\027\024\ \f\021\036\005 \021\036\027\007\036\030\027\024\020\024 )Tj 0 Tw T* (\023\030\024\006\036\f\f\026 [32].)Tj 0.155 Tw T* (\037\036\035\026\016 \f\036\030\017\016 \017\f\f\035\036\007\024\r\026\027\ \017\005 \002\t\035\026 \023\024\f\r\016\013\036\027\026 \024\006\036\027\ \022\036 )Tj 0.19 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \211\225\224 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.295 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \023\030\036\023\026\030\026\021\026\n\017 \r\ \024 2 \035\017\027\017\017 \021\036\030\026\023\017\017. \224\026\022, \ )Tj 0.095 Tw T* (Biemans V. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \031\f\021\026\027\024\r\017\035\017, \004\021\024 \031\ )Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \207\025, )Tj 0.294 Tw T* [(\023\024\021\036\030\016\r\001\017\b \024\021\r\036\021 \017-\205\203\210\ , )0.5(\r\036\030\024\016\021\027\024\f\021\034 \007\024\f\021\017\032\036\027\017\ \016 )]TJ 0.151 Tw T* (\022\035\017\027\017\004\036\f\022\024\005 \030\036\n\017\f\f\017\017 \002\ \036 \206\025 $OR: 2,58, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.151 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004$, )Tj -0.015 Tw T* (\035\026\002\024\030\026\021\024\030\027\024\005 \030\036\n\017\f\f\017\017\ $OR: 2,34, )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf -0.015 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,027$ \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\027\017\030\024\r\026\027\027\024\005 \022\035\017\027\017\004\036\f\022\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\024\030\026\021\024\030\027\024\005 \030\036\n\017\f\f\017\017\ )Tj -0.021 Tw T* (\002\036 \206\025 $OR: 2,74, )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf -0.021 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,014$ \004\036\030\036 52 \002\t\035\026 \r\t\001\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 )Tj 0.14 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \030\036\031\035\034\021\026\021\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\036)Tj 0 Tw (-)Tj 0.069 Tw T* [(\024\023\026\f\027\024\f\021\017 )0.6(\002\t\035\017 )0.5(\f\024\023\024\f\021\026\r\017\n\t )0.6(\n\036\032\007\031 )0.5(\007\r\031\n\016 )0.5(\023\030\036\023\026\030\026)]TJ 0 Tw (-)Tj 0.114 Tw T* (\021\026\n\017. \237\021\017 \007\026\027\027\t\036 \f\r\017\007\036\021\ \036\035\034\f\021\r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\024\005 )Tj 0.084 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\017 \017, \022\024\f\r\036\027\ \027\024, \024)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\024\005 \r\t\032\017)Tj 0 Tw (-)Tj 0.058 Tw T* (\r\026\036\n\024\f\021\017 \211\225\224 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 \r\024 2-\005 \035\017\027\017\017 \021\036)Tj 0 Tw (-)Tj T* (\030\026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 [33].)Tj 0.044 Tw T* (\225\b\024\007\027\t\036 \030\036\031\035\034\021\026\021\t \002\t\035\017\ \023\024\035\031\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \235\030\026\027\006\031)Tj 0 Tw (-)Tj 0.497 Tw T* (\f\022\024\020\024 \n\027\024\020\024\006\036\027\021\030\024\r\024\020\024\ \f\030\026\r\027\017\021\036\035\034\027\024\020\024 \027\026\002\035\033\ \007\026)Tj 0 Tw (-)Tj 0.012 Tw T* (\021\036\035\034\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016\ \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \207\025, \022\024\021\024\030\024\036\ \023\030\024)Tj 0 Tw (-)Tj 0.242 Tw T* (\007\036\n\024\027\f\021\030\017\030\024\r\026\035\024 \023\030\036\017\n\ \031\013\036\f\021\r\024 \211\225\224 $107 \004\036\035\024\r\036\022$\ )Tj 0.124 Tw T* (\027\026\007 \200\213\212\210 $132 \004\036\035\024\r\036\022\026$ \r\024\ 2-\005 \035\017\027\017\017 \021\036\030\026\023\017\017 \023\024)Tj 0 Tw (-)Tj 0.046 Tw T* (\f\035\036 \027\036\031\007\026\004\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\205\203\210-\256. \224\026\022, \f\021\024\005\022\026\016 \022\035\ \017\027\017\004\036\f\022\026\016 \030\036)Tj 0 Tw (-)Tj 0.016 Tw T* (\n\017\f\f\017\016 \002\t\035\026 \007\024\f\021\017\020\027\031\021\026\ \031)Tj /Span<>> BDC ( )Tj EMC (54,4% \027\026)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 \023\030\024\021\017\r 38,3% )Tj 0.045 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,92; 95% \212\230 1,09\2263,39$, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017)Tj 0 Tw (-)Tj -0.028 Tw T* (\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\220\f\022\026\035\026\006\017\017 \f\b\036\n\t \035\036\004\036\027\017\ \016 \002\t\035\026 \023\024\004\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (2 \030\026\026 )Tj 0.018 Tw T* [(\r\t\001\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\017 )0.5(\200\213\212\210: )0.5(53,3% )0.5(\023\030\024\021\017\r )0.5(30,1% \027\026)]TJ /Span<>> BDC ( )Tj EMC 20.392 0 Td (\211\225\224. )Tj 0.157 Tw -20.392 -1.218 Td [(\207\t\035\026 )0.5(\021\026\022\032\036 )0.6(\023\024\022\026\026\027\026 )0.5(\002\024\035\036\036 )0.6(\r\t\f\024\022\026\016 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )]TJ 0.116 Tw T* (\021\036\030\026\023\017\017 \211\225\224 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \020\024\007\026: \035\036\004\036\027\017\ \036 \023\030\024\007\024\035\032\017\035\017 )Tj 0.096 Tw T* (71,5% \023\026\006\017\036\027\021\024\r \023\030\024\021\017\r 49,7% \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2,54; )Tj 0 Tw T* (95% \212\230 1,40\2264,62$ [34].)Tj 0.085 Tw T* (\200 \207\030\017\021\026\027\f\022\024\n \023\030\024\f\023\036\022\021\ \017\r\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \f\030\026\r\ \027\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\r\026\035\017 \220\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\034 \211\225\224 $45 \023\026\006\017\ )Tj 0 Tw (-)Tj 0.037 Tw T* (\036\027\021\024\r$ \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 $85 \023\026\006\017\036\027\021\024\r$ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \030\036\235\030\026\022\021\036\030\027\024\005 )Tj 0.045 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\017\205\203\210 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 12 \n\036\f\016\006\036\r. \217\036\n\017\f\ \f\017\016 \002\036 \206\025 \002\t\035\026 )Tj 0.261 Tw T* (\r\t\001\036 \f\030\036\007\017 \023\026\006\017\036\027\021\024\r, \023\ \024\035\031\004\026\r\001\017\b \211\225\224 $\210\221 2,01, )Tj 0.018 Tw T* (95% \212\230 0,89\2264,56, P)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,095$. \200\t\032\017\r\026\036\n\024\f\021\034 \211\225\224 \021\026\022\ )Tj 0 Tw (-)Tj 0.156 Tw T* [(\032\036 )0.5(\002\t\035\026 \007\024\f\021\024\r\036\030\027\024 )0.5(\r\t\001\036 )0.5(\200\213\212\210 )0.5(\r\024 2 )0.5(\035\017\027\017\017: )0.5(\004\036\030\036 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.5021 56.0378 Tm (109)Tj ET endstream endobj 535 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.004 Tc 0.196 Tw 10 0 0 10 70.8661 724.8299 Tm (\210\002\013\036\027\026\006\017\024\027\026\035\034\027\024\036 \022\024\ \020\024\030\021\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036,\ \023\030\024\r\036)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.031 Tw 0 -1.218 TD (\007\036\027\027\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (\212\026\027\017\017 \f\030\036\007\017 827 \023\026\006\017\036\027\021\ \024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025, \023\024\007\021\r\036\030\007\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.066 Tw T* (\035\024 \f\024\023\024\f\021\026\r\017\n\024\f\021\034 \n\036\032\007\031\ \202\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (\230\203\205 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\024\004\022\017 \030\036\027\017\016)-4( )]TJ 0.072 Tw T* (\004\026\f\021\024\021\t \020\024\f\023\017\021\026\035\017\026\006\017\ \005, \f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,81;)-4( )]TJ 0.083 Tw T* (95% \212\230: 0,55\2261,2$, \f\036\030\034\036\027\t\b \024\023\036\030\ \026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\002\030\033\001\027\024\005)-4( )]TJ 0.056 Tw T* (\023\024\035\024\f\021\017 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,24; 95% \212\230: 0,66\2262,33$ \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\235\036\022\006\017\005,)-4( )]TJ -0.041 Tw 0 -1.218 TD [(\021\030\036\002\031\033\013\017\b )0.5(\020\024\f\023\017\021\026\035\017\026\006\017\017 )0.5($\210\221)]TJ /Span<>> BDC ( )Tj EMC 13.41 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.683 0 Td [(1,06; )0.5(95% )0.5(\212\230: )0.5(0,26\226)]TJ 0.041 Tw -14.094 -1.218 Td (4,21$, \004\021\024 \022\024\f\r\036\027\027\024 \020\024\r\024\030\017\ \021 \024\002 \024\007\017\027\026\022\024\r\024\005 \r\t\032\017\r\026\036\ )Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0 -1.218 TD (\n\024\f\021\017 \023\030\036\023\026\030\026\021\024\r. \204\036\007\017\ \026\027\026 \027\026\002\035\033\007\036\027\017\016 2,3 \020\024\007\026\ .)Tj 0 Tc -0.085 Tw T* (\025\024\030\036\005\f\022\017\036 \017\f\f\035\036\007\024\r\026\021\036\ \035\017, \017\f\023\024\035\034\031\016 \002\026\031 \027\026\006\017\ \024\027\026\035\034)Tj 0 Tw (-)Tj 0.009 Tw T* (\027\024\020\024 \n\036\007\017\006\017\027\f\022\024\020\024 \f\021\030\ \026\b\024\r\026\027\017\016, \023\030\024\f\035\036\007\017\035\017 \023\ \024\022\026\026)Tj 0 Tw (-)Tj -0.069 Tw T* (\021\036\035\017 \r\t\032\017\r\026\036\n\024\f\021\017 \021\036\030\026\ \023\017\017 \230\203\205, \202\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (\037\213\217\224\210 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 )Tj 0.016 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\230\203\205, \202\212\202, \206\210\214 \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 [23]. \215\024\022\026\026\021\036\035\017 \r\t)Tj 0 Tw (-)Tj 0.07 Tw 0 -1.218 TD [(\032\017\r\026\036\n\024\f\021\017 )0.5(\007\035\016 )0.5(\230\203\205 \017)]TJ /Span<>> BDC ( )Tj EMC 10.027 0 Td [(\202\212\202 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\207\025 )0.5(\002\t\035\017 )0.5(\023\024\035\027\024\f\021\034\033 )]TJ 0.013 Tw -10.027 -1.218 Td (\f\024\023\024\f\021\026\r\017\n\t: \007\024\035\016 \002\024\035\034\027\ \t\b, \023\030\024\007\024\035\032\017\r\001\017\b \035\036\004\036\027\017\ \036, )Tj 0.109 Tw 0 -1.218 TD (\f\024\f\021\026\r\017\035\026 \024\022\024\035\024 80% \004\036\030\036\ 1 \020\024\007, 66\22667%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 )Tj 0.155 Tw T* (3)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (50%)Tj /Span<>> BDC ( )Tj EMC (\227 \004\036\030\036 5 \035\036\021. \212\035\016 \037\213\217\224\210\ \023\024\022\026\026\021\036)Tj 0 Tw (-)Tj 0.153 Tw T* (\035\017 \002\t\035\017 \027\026\004\017\021\036\035\034\027\024 \027\017\ \032\036 $65%, 41% \017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\020\024 20% )Tj 0.258 Tw T* [(\023\026\006\017\036\027\021\024\r )0.5(\023\030\024\007\024\035\032\026\035\017 \023\030\017\036\n )0.5(\023\030\036\023\026\030\026\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\036 \032\036 )Tj 0.133 Tw T* (\r\030\036\n\036\027\027\t\036 \023\030\024\n\036\032\031\021\022\017$.\ \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 \023\024\022\026\026\021\036\035\017 \r\t\032\017)Tj 0 Tw (-)Tj 0.013 Tw T* (\r\026\036\n\024\f\021\017 $\023\030\024\007\024\035\032\036\027\017\016\ \021\036\030\026\023\017\017$ \021\026\022\032\036 \002\t\035\017 \024\ \007\017\027\026)Tj 0 Tw (-)Tj 0.009 Tw T* (\022\024\r\t: \007\035\016 \230\203\205 66,1% \017)Tj /Span<>> BDC ( )Tj EMC (47% \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 \202\212\202 62,4% \017)Tj /Span<>> BDC ( )Tj EMC (47,6% )Tj 0.139 Tw T* [(\004\036\030\036 )0.6(1 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.465 0 Td [(3 )0.5(\020\024\007\026, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027\027\024. )0.5(\202\r\021\024\030\t )0.6(\024\021\n\036\004\026\033\021 )]TJ -0.021 Tw -4.465 -1.218 Td (\007\r\026 \017\027\021\036\030\036\f\027\t\b \n\024\n\036\027\021\026. \ \200\024-\023\036\030\r\t\b, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 \r\t\032\017\r\026)Tj 0 Tw (-)Tj -0.023 Tw T* [(\036\n\024\f\021\034 )0.5(\230\203\205 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.812 0 Td [(\202\212\202 )0.6(\002\t\035\026 )0.5(\027\017\032\036, )0.5(\004\036\n )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.179 0 Td [(\207\025. )0.5(\200\024-\r\021\024\030\t\b, )]TJ 0.117 Tw -15.992 -1.218 Td (\002\024\035\034\027\t\036, \027\026\004\026\r\001\017\036 \035\036\004\036\ \027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \017\n\036\035\017 \002\024\035\036\036 \r\t)Tj 0 Tw (-)Tj 0.158 Tw T* (\f\024\022\031\033 \r\036\030\024\016\021\027\024\f\021\034 \023\036\030\ \036\022\035\033\004\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \023\030\036\023\026)Tj 0 Tw (-)Tj 0.079 Tw T* (\030\026\021, \004\036\n \023\026\006\017\036\027\021\t, \f\021\026\030\021\ \024\r\026\r\001\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\230\203\205, \022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025, )Tj 0.092 Tw T* (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \254\025. \225\035\036\007\031\036\021 \024\021\n\036\021\017\ \021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.167 Tw T* (\r\026\027\017\017 \023\036\030\036\022\035\033\004\036\027\017\036 \023\ \030\024\017\f\b\024\007\017\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \024\007\027\024\020\024 )Tj 0.135 Tw T* (\022\035\026\f\f\026 \017-\205\203\210, \004\021\024 \026\r\036\007\024\ \n\024 \f\027\017\032\026\036\021 \r\t\032\017\r\026\036\n\024\f\021\034\ )Tj 0.228 Tw T* (\021\036\030\026\023\017\017. \215\024\022\026\026\021\036\035\017 \r\t\ \032\017\r\026\036\n\024\f\021\017 \206\210\214 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.133 Tw T* [(\023\036\030\r\024\020\024 )0.6(\020\024\007\026 )0.5(\002\t\035\017 )0.6(\027\017\032\036, )0.6(\004\036\n )0.6(\007\035\016 )0.6(\007\030\031\020\017\b )0.6(\017-\205\203\210, )0.6(\027\024 )]TJ 0.078 Tw T* (\002\036 \007\024\f\021\024\r\036\030\027\t\b \024\021\035\017\004\017\005\ . \230)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\024\r, \f\023\024\f\024\002\f\021\r\031)Tj 0 Tw (-)Tj 0.047 Tw T* (\033\013\017\b \f\027\017\032\036\027\017\033 \r\t\032\017\r\026\036\n\024\ \f\021\017 \023\030\036\023\026\030\026\021\024\r, \024\021\n\036\004\036\ \027 )Tj 0.175 Tw T* (\023\030\017\036\n \f\021\036\030\024\017\007\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 \021\036\030\026\023\017\017 \206\230\207\215. \ \025\030\024\n\036 )Tj 0.05 Tw T* (\021\024\020\024, \023\024\022\026\026\027\024, \004\021\024 \f\027\017\ \032\036\027\017\036 \r\t\032\017\r\026\036\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\017\f\022\017 )Tj -0.034 Tw T* (\023\036\030\036\022\035\033\004\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \206\230\207\215 \002\t\035\017 \r\t\001\036 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 )Tj -0.026 Tw T* (\035\036\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\030\024\235\017\035\034\027\t\b \002\024\035\034\027\017\006\ \026\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f\024 )Tj 0.054 Tw T* (\f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\t\n\017 \006\036\ \027\021\030\026\n\017 [23]. \237\021\026 \032\036 \020\030\031\023\023\026\ )Tj -0.042 Tw T* (\031\004\036\027\t\b \023\030\024\r\036\035\026 \030\036\021\030\024\f\023\ \036\022\021\017\r\027\t\005 \026\027\026\035\017 \017\f\021\024\030\017\ \005 \002\024)Tj 0 Tw (-)Tj 0.12 Tw T* (\035\036\027\017 113 \002\017\024\027\026\017\r\027\t\b \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\254\025, \023\024\035\031\004\026\r\001\017\b )Tj 0.075 Tw T* (\230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC [(\202\212\202. \203\036 \002\t\035\024 \f\031\013\036\f\021\r\036\027\027\ \t\b )0.5(\030\026\035\017\004\017\005 \n\036\032\007\031 )]TJ 0.071 Tw T* (\007\r\031\n\016 \023\030\036\023\026\030\026\021\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \r\t\032\017\r\026\036\n\024\f\021\ \017 \021\036)Tj 0 Tw (-)Tj 0.067 Tw T* (\030\026\023\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (52 \027\036\007\036\035\036 \027\026\002\035\033\007\036\027\017\016 $\230\ \203\205 55,4% \023\030\024\021\017\r )Tj 0.394 Tw T* (\202\212\202 50,0%$. \215\024\r\t\001\036\027\027\t\005 \031\030\024\r\036\ \027\034 \225-\030\036\026\022\021\017\r\027\024\020\024 )Tj 0.087 Tw T* (\002\036\035\022\026 $\002\024\035\036\036 5 \n\020/\035$ \002\t\035 \ \027\026\004\017\n\t\n \235\026\022\021\024\030\024\n \023\024\021\036)Tj 0 Tw (-)Tj 0.081 Tw T* (\030\017 \024\021\r\036\021\026 \007\035\016 \024\002\024\017\b \023\030\ \036\023\026\030\026\021\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\017\024\007\026 )Tj 0.021 Tw T* (\027\026\002\035\033\007\036\027\017\016 \004\026\f\021\024\021\026 \203\ \254 \f\031\013\036\f\021\r\036\027\027\024 \027\036 \030\026\035\017\004\ \026\035\017\f\034 )Tj 0 Tw T* (\n\036\032\007\031 \007\r\031\n\016 \020\030\031\023\023\026\n\017 [24].\ )Tj 0.348 Tw T* [(\230\f\f\035\036\007\024\r\026\027\017\036 EVOL)65(VE \f\021\026\r\017\035\024 \f\r\024\036\005 \006\036\035\034\033 \f\030\ \026\r)]TJ 0 Tw (-)Tj 0.177 Tw T* (\027\017\021\034 \220\235\235\036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \200\213\212\210 \017)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210 )Tj 0.275 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\035\034\027\024\005 \023\030\026\022\021\017\022\036 \031)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\027\026\017\r\027\t\b \023\026\006\017\036\027\021\024\r \254\ \025 )Tj 0.1 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\207\025. \230\f\f\035\036\007\024\r\026\027\017\036 \007\035\017\035\024\ \f\034 2 \020\024\007\026, \002\t\035\024 \r\022\035\033\004\036\027\024\ )Tj 0.121 Tw 23.244 64.543 Td (604)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \254\025 \017)Tj /Span<>> BDC ( )Tj EMC (491 \023\026\006\017\036\027\021\024\r \207\025. \025)Tj /Span<>> BDC ( )Tj EMC (24 \n\036\f\016\006\026\n )Tj 0.525 Tw T* [(\024\002\013\026\016 )0.5(\022\035\017\027\017\004\036\f\022\026\016 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6($\022\035\017\027\017\004\036\f\022\026\016 )]TJ 0.689 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\n\017\f\ \f\017\016/\024\021\r\036\021$ \023\030\036\023\026\030\026\021\024\r )Tj 0.181 Tw T* (\007\r\031\b \022\035\026\f\f\024\r \002\t\035\026 \f\024\023\024\f\021\026\ \r\017\n\026, \027\024 \030\026\035\017\004\017\016 \022\026\f\026)Tj 0 Tw (-)Tj 0.279 Tw T* (\035\017\f\034 \030\017\f\022\026 \f\036\030\034\036\027\t\b \203\254 \017\ )Tj /Span<>> BDC ( )Tj EMC (\f\036\030\034\036\027\t\b \017\027\235\036\022\006\017\005. )Tj 0.273 Tw T* (\212\024\023\024\035\027\017\021\036\035\034\027\024 \024\023\030\036\007\ \036\035\016\035\017 \r\t\032\017\r\026\036\n\024\f\021\034 \021\036\030\ \026\023\017\017 )Tj -0.005 Tw 0 -1.218 TD (\004\036\030\036 2 \020\024\007\026, \022\024\021\024\030\031\033 \024\006\ \036\027\017\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \f\024\b\030\026\027\036)Tj 0 Tw (-)Tj -0.061 Tw 0 -1.218 TD (\027\017\016 \023\036\030\r\024\027\026\004\026\035\034\027\024\005 \021\ \036\030\026\023\017\017, \004\026\f\021\024\021\036 \220\f\022\026\035\026\ \006\017\017 \007\024\t )Tj -0.001 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \024\002\024\f\021\030\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\ \034\f\021\r, )Tj 0.27 Tw T* (\f\r\016\026\027\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025. \215\024\022\026\026\021\036\035\017 \r\t\032\017\r\026\036\ \n\024\f\021\017 \002\t\035\017 )Tj 0.252 Tw T* [(\007\024\f\021\024\r\036\030\027\024 )0.5(\r\t\001\036 \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\254\025, )0.5(\023\030\017\027\017\n\026\r\001\017\b )]TJ 0.124 Tw T* (\200\213\212\210. \231\026\f\021\024\021\026 \024\002\024\f\021\030\036\027\ \017\005 \254\025 \002\t\035\026 \027\017\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\017\017 \200\213\212\210 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,58 [0,45\2260,76]$. \212\030\031\020\017\036 \030\036\031\035\034\021\ \026\021\t )Tj 0.229 Tw 0 -1.218 TD (\f\031\013\036\f\021\r\036\027\027\024 \027\036 \030\026\035\017\004\026\ \035\017\f\034 \n\036\032\007\031 \020\030\031\023\023\026\n\017 \023\030\ \036)Tj 0 Tw (-)Tj 0.062 Tw 0 -1.218 TD (\023\026\030\026\021\024\r. \206\035\026\r\027\t\005 \r\t\r\024\007)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \035\017\027\017\017 \021\036\030\026\023\017\017 \022\026\022 )Tj 0.071 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.825 0 Td [(\254\025, )0.5(\021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC 4.049 0 Td [(\023\030\017 )0.5(\207\025 \200\213\212\210 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.548 0 Td [(\017-\205\203\210 )0.5(\017\n\036\033\021 )0.5(\024\007\017\027\026\022\024)]TJ 0 Tw (-)Tj -0.021 Tw -12.421 -1.218 Td [(\r\031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034, )0.6(\027\024 )0.5(\200\213\212\210 )0.6(\017\n\036\036\021 )0.5(\023\030\017\024\030\017\021\036\021 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 20.356 0 Td (\f\004\036\021 )Tj 0.11 Tw -20.356 -1.218 Td (\002\024\035\034\001\036\005 \002\036\024\023\026\f\027\024\f\021\017)Tj /T1_1 1 Tf 0 Tw (.)Tj /T1_0 1 Tf 0.11 Tw ( \212\024\023\024\035\027\017\021\036\035\034\027\t\005 \026\027\026\035\ \017 \023\024)Tj 0 Tw (-)Tj 0.122 Tw T* (\r\024\035\017\035 \023\030\036\007\023\024\035\024\032\017\021\034, \004\ \021\024 \220\235\235\036\022\021\017\r\027\024\f\021\034 \017-\205\203\210\ \027\036 )Tj 0.231 Tw T* (\f\027\017\032\026\036\021\f\016 \r\024 \r\021\024\030\024\005 \035\017\027\ \017\017 \021\036\030\026\023\017\017 \023\024\f\035\036 \023\024\021\036\ \030\017 )Tj -0.004 Tw T* [(\024\021\r\036\021\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\200\213\212\210 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\005 )0.5(\035\017\027\017\017. \210\007\027\026\022\024 )0.5(\026\r\021\024\030\t )0.5(\024\021\n\036)]TJ 0 Tw (-)Tj 0.024 Tw T* [(\004\026\033\021, )0.5(\004\021\024 \007\035\016 \021\026\022\024\020\024 \031\021\r\036\030\032\ \007\036\027\017\016 )0.5(\027\036\024\002\b\024\007\017\n\t \002\024\035\036\036 )]TJ -0.004 Tw T* (\r\036\f\024\n\t\036 \007\024\022\026\026\021\036\035\034\f\021\r\026 [\ 25]. \215\024\007\021\r\036\030\032\007\036\027\017\036\n \220\021\024\020\ \024 )Tj 0.116 Tw T* (\032\036 \023\024\035\024\032\036\027\017\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \n\024\032\036\021 \f\035\031\032\017\021\034 \030\026\002\024\021\ \026, \022\024\021\024)Tj 0 Tw (-)Tj 0.236 Tw T* (\030\026\016 \023\024\022\026\026\035\026, \004\021\024 \n\036\007\017\026\ \027\026 \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017\ )Tj /T1_1 1 Tf 0 Tw (1-\t )Tj T* (\027\022\020\022\022)Tj /T1_0 1 Tf 0.151 Tw ( \021\036\030\026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \002\t\035\026 \027\026\004\017\n\024 \r\t\001\036 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.013 Tw T* (\023\024\035\034\024\r\026\027\017\017 \200\213\212\210 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\205\203\210 $842 \023\030\024\021\017\r )Tj 0.114 Tw T* (557 \007\027\036\005, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.114 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,041$. \200)Tj /Span<>> BDC ( )Tj EMC [(\021\024\032\036 )0.5(\r\030\036\n\016, \007\024\035\016 \023\026\006\017\036\027\021\024\r )]TJ 0.019 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \026\027\021\017-\205\203\210 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 6 \n\036\f. \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \035\017)Tj 0 Tw (-)Tj -0.031 Tw T* (\027\017\017 \f\024\f\021\026\r\017\035\026 74,8%, \026)Tj /Span<>> BDC ( )Tj EMC (\r\024 2-\005 \035\017\027\017\017 \023\024\f\035\036 \200\213\212\210 \002\ \t\035\026 )Tj 0.042 Tw T* (\r\t\001\036)Tj /Span<>> BDC ( )Tj EMC (\227 85,1% [26]. \202\r\021\024\030\t \f\004\017\021\026\033\021, \004\021\ \024 \030\036\031\035\034\021\026\021\t )Tj 0.318 Tw T* (\030\026\002\024\021\t \023\024\r\024\035\016\033\021 \024\023\030\036\007\ \036\035\017\021\034 \023\024\f\035\036\007\024\r\026\021\036\035\034\027\ \024\f\021\034 )Tj 0.048 Tw T* (\023\030\017\n\036\027\036\027\017\016 \026\027\021\017-\205\203\210 \023\ \030\036\023\026\030\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024, )Tj -0.023 Tw T* (\024\002\024\f\027\024\r\026\027\027\024\f\021\034 \023\030\017\n\036\027\ \036\027\017\016 \200\213\212\210 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210 \031)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\027\026)Tj 0 Tw (-)Tj 0.023 Tw T* (\017\r\027\t\b \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \r)Tj /Span<>> BDC ( )Tj EMC (1 \035\017\027\017\017 \026\f\f\024\006\017\017\030\024\r\026\035\024\f\034\ \f\024 )Tj 0.082 Tw T* [(\027\026\004\017\n\t\n )0.5(\031\r\036\035\017\004\036\027\017\036\n )0.5(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\017 )0.6(\035\036\004\036\027\017\016 )]TJ 0.074 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036 \200\213\212\210 \r\024 2)Tj /Span<>> BDC ( )Tj EMC (\035\017)Tj 0 Tw (-)Tj 0.23 Tw T* (\027\017\017 \023\024\f\035\036 \017-\205\203\210 \023\030\036\023\026\030\ \026\021\024\r \017\n\036\035\024 \002\024\035\036\036 \027\017\022\031\ \033 )Tj 0.031 Tw T* (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \035\036\ \004\036\027\017\016, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 )Tj 0 Tw T* (\200\213\212\210 \r)Tj /Span<>> BDC ( )Tj EMC (1 \035\017\027\017\017.)Tj 0.292 Tw T* (\203\036\024\007\027\024\027\026\004\027\024\f\021\034 \031\022\026\026\ \027\027\t\b \023\024\035\024\032\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024)Tj 0 Tw (-)Tj 0.365 Tw T* (\007\017\n\024\f\021\034 \007\024\023\024\035\027\017\021\036\035\034\027\ \t\b \017\f\f\035\036\007\024\r\026\027\017\005 \023\024\007\021\r\036\030\ \032)Tj 0 Tw (-)Tj 0.209 Tw T* (\007\026\036\021\f\016 \030\026\002\024\021\024\005 Miller \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \030\036\031\035\034\021\026\021\t \022\024\021\024\030\ \024\005 )Tj 0.004 Tw T* (\002\t\035\017 \023\030\016\n\024 \023\030\024\021\017\r\024\023\024\035\ \024\032\027\t \r\t\f\022\026\026\027\027\t\n \r\t\001\036 \023\024)Tj 0 Tw (-)Tj 0.106 Tw T* (\035\024\032\036\027\017\016\n \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\017\n\031\013\036\f\021\r\026\b \017-\205\203\210 \r\024 \r\ \021\024\030\024\005 \035\017\027\017\017 )Tj 0.054 Tw T* (\021\036\030\026\023\017\017 \023\024\f\035\036 \200\213\212\210. \202\r\ \021\024\030\t \f\021\026\r\017\035\017 \006\036\035\034\033 \024\006\036\ \027\017\021\034 )Tj 0.318 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 1.024 0 Td [(\030\036\026\035\034\027\024\005 )0.5(\023\030\026\022\021\017\022\036 )0.5(\023\030\017\024\030\017\021\036\021\027\024\f\021\034 )0.6(\021\036\030\026\023\017\017 )0.5(2-\005 )]TJ 0.122 Tw -1.024 -1.218 Td (\035\017\027\017\017 \007\035\016 \200\213\212\210 \023\024\f\035\036 \017\ -\205\203\210 \017\035\017, \027\026\024\002\024\030\024\021, \017-\205\203\ \210 )Tj 0.033 Tw T* (\023\024\f\035\036 \200\213\212\210 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025. \210\006\036\027\017\r\026\035\017 \r\t\032\017\r\026\036\n\024\ \f\021\034 $\007\024\035\033 )Tj 0.175 Tw T* [(\002\024\035\034\027\t\b, )0.5(\023\030\024\007\024\035\032\026\r\001\017\b )0.6(\035\036\004\036\027\017\036 )0.6(\004\036\030\036 )0.5(52 )0.5(\027\036\007\036\035\017$, )]TJ 0.347 Tw T* (\004\026\f\021\024\021\031 \220\022\f\021\030\036\027\027\t\b \020\024\f\ \023\017\021\026\035\017\026\006\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\220\022\021\024\n\017\005 )Tj 0.07 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\021 \032\036 \023\036\030\017\024\007 \r\030\036\n\036\027\017.\ \210\022\026\026\035\024\f\034, \004\021\024 \007\024\035\016 \023\026\ \006\017)Tj 0 Tw (-)Tj 0.094 Tw T* (\036\027\021\024\r, \023\024\035\031\004\026\r\001\017\b \200\213\212\210\ \023\024\f\035\036 \017-\205\203\210 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\026\r)Tj 0 Tw (-)Tj 0.223 Tw T* (\001\017\b \035\036\004\036\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (52 \027\036\007\036\035\036 \002\t\035\026 \007\024\f\021\024\r\036\030\027\ \024 \r\t\001\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.7902 56.0378 Tm (108)Tj ET endstream endobj 534 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 289.5098 42.7216 Tm [(Compar)21(ativ)12.1(e ef)-31(f)-21(icacy and sur)-21(viv)10(al of\022biologics in inflammator)-31(y bow)11(el )]TJ -0.033 -1 Td [(disease in dif)-30.9(fer)31(ent lines of\022th)11(er)21.1(apy: th)11(e\022clinician\226)63(s vie)11(w of\022th)11(e pr)20(oblem)]TJ -32.899 1 Td [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-10(\026\n \b\022\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-\b\t\235\f\t\f\017\t\240\002 )]TJ 0 -1 TD [(\210\b\025\013\025\020\b\213\f\205\007\b\002 \223\017\f\223\005\017\005\026\ )11(\025\016 $\031\030\214\034$ \223\017\b\022\016\025\205\223\005\013\b\026\ )11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 )]TJ T* [(\007\b\203\f\213\t\b\007\005 \016\022\017\005\001\t\240\002 \013\b\t\b\002\ \026)11(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-10(\013\b\t\b\216\b\205)-9.9(\026)11(\005 \t\005\022\223\017\025\210\013\f\024\220)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.082 Tw 10 0 0 10 42.5197 724.8299 Tm (\200\213\212\210, A\212A \017)Tj /Span<>> BDC ( )Tj EMC (\206\210\214 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 [15]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 \002\t\035\017 )Tj 0.044 Tw 0 -1.218 TD (\r\022\035\033\004\036\027\t 463 \023\026\006\017\036\027\021\026 $\200\ \213\212\210 )Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (187; A\212A )Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (168; )Tj 0 Tw T* (\206\210\214 )Tj /T1_2 1 Tf 1.769 0 Td (n)Tj /T1_1 1 Tf -0.038 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(108$ \f\024 \f\030\036\007\027\017\n )0.5(\023\036\030\017\024\007\024\n \027\026\002\035\033\007\036\027\017\016 \ )0.5(48)]TJ /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.06 Tw -1.769 -1.218 Td (\007\036\035\034. \215\024\035\024\r\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\026\006\017\036\027\021\024\r \002\t\035\017 \002\017\ \024\027\026\017\r\027\t)Tj 0 Tw (-)Tj 0.472 Tw T* (\n\017, 80,6% \007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \f\021\ \036\030\024\017\007\024\026\r\017\f\017\n\024\f\021\034 )Tj 0.204 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\024\035\024\r\017\027\t \023\030\017\027\017\n\ \026\035\017 \f\017\f\021\036\n\027\t\036 \f\021\036\030\024\017\007\t )Tj 0.132 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 \035\036\004\036\027\017\016 \206\230\207\215. \ \231\036\030\036 48 \027\036\007\036\035\034 \002\036\f\f\021\036\030\024\ )Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD (\017\007\027\026\016 \030\036\n\017\f\f\017\016 \024\021\n\036\004\036\027\ \026 \031)Tj /Span<>> BDC ( )Tj EMC (51% \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.102 Tw T* (\200\213\212\210, \031)Tj /Span<>> BDC ( )Tj EMC (31% \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 A\212A $)Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.102 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002$ )Tj 0.046 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.796 0 Td [(\031 )0.5(29% )0.6(\023\026\006\017\036\027\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.361 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.031 0 Td [(\020\030\031\023\023\036 )0.6(\206\210\214 )0.5($)]TJ /T1_2 1 Tf 0 Tw (\033)Tj /T1_1 1 Tf 0.046 Tw /Span<>> BDC ( )Tj EMC 6.043 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.778 0 Td [(0,001 )0.5(\n\036\032\007\031 )]TJ 0.271 Tw -17.011 -1.218 Td (\200\213\212\210 \017)Tj /Span<>> BDC ( )Tj EMC (\206\210\214$. \215\026\006\017\036\027\021\t, \023\024\035\031\004\026\ \r\001\017\036 \200\213\212\210, \017\n\036\035\017 )Tj 0.042 Tw T* (\n\036\027\034\001\017\036 \030\017\f\022\017 \f\027\017\032\036\027\017\ \016 \r\t\032\017\r\026\036\n\024\f\021\017 $\023\030\036\022\030\026\013\ \036)Tj 0 Tw (-)Tj 0.022 Tw 0 -1.218 TD [(\027\017\016 )0.5(\021\036\030\026\023\017\017$ )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 6.984 0 Td [(\f\030\026\r\027\036\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.504 0 Td [(\023\024\035\031\004\026\r\001\017\n\017 )0.6(A\212A )0.5($HR: )]TJ 0 Tw -12.488 -1.218 Td (0,42, )Tj /T1_2 1 Tf 2.068 0 Td (p)Tj /T1_1 1 Tf -0.035 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$ \017)Tj /Span<>> BDC ( )Tj EMC (\206\210\214 $HR: 0,30, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.035 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC 12.055 0 Td (0,001$. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036)Tj 0 Tw (-)Tj -0.018 Tw -14.123 -1.218 Td (\n\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\024\035\031\004\026\r\001\017\b\ A\212A, \030\017\f\022\017 \023\030\036\022\030\026\013\036\027\017\016\ )Tj 0.073 Tw 0 -1.218 TD (\021\036\030\026\023\017\017 \002\t\035\017 \027\017\032\036 $\021.\036\ . \r\t\001\036 \r\036\030\024\016\021\027\024\f\021\034 \r\t\032\017\r\026\ )Tj 0 Tw (-)Tj 0.105 Tw T* (\036\n\024\f\021\017$ \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n\017, \022\021\024 \023\024\035\031\004\026\035 \206O\214 $HR\ : )Tj 0 Tw T* (0,71, )Tj /T1_2 1 Tf 2.165 0 Td (\033)Tj /T1_1 1 Tf 0.062 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,048$. \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \220\021\024 \017\f\f\035\036\007\024\r\026\027\017\036\ \r\t\016\r\017\035\024, )Tj 0.011 Tw -2.165 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\005 )0.5(\f\021\024\030\024\027\t, )0.5(\023\030\036\017\n\031\013\036\f\021\r\024 )0.5(\200\213\212\210 )0.5(\027\026\007 A\212A )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.351 0 Td (\206\210\214, )Tj 0.039 Tw -20.351 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC [(\007\030\031\020\024\005 \f\021\024\030\024\027\t, \202\212\202 )0.5(\027\026\007 \206\210\214 \f)]TJ /Span<>> BDC ( )Tj EMC [(\021\024\004\022\017 \030\036\027\017\016 )0.5(\024\007\027\024)]TJ 0 Tw (-)Tj 0.162 Tw T* (\020\024\007\017\004\027\024\005 \r\t\032\017\r\026\036\n\024\f\021\017 \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\017 \002\036\f\f\021\036\030\024)Tj 0 Tw (-)Tj T* (\017\007\027\024\005 \030\036\n\017\f\f\017\017.)Tj 0.006 Tw T* [(\225\030\026\r\027\017\021\036\035\034\027\t\005 )0.5(\n\036\021\026\026\027\026\035\017 )0.5(\230\203\205 \017)]TJ /Span<>> BDC ( )Tj EMC [(\202\212\202 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC (\002\017\024\027\026\017\r\027\t\b )Tj 0.02 Tw T* (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\254\025 \027\036 \r\t\016\r\017\035 \030\026\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 )Tj 0.002 Tw T* (\023\030\036\023\026\030\026\021\024\r \004\036\030\036 1 \017)Tj /Span<>> BDC ( )Tj EMC (2 \020\024\007\026, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \004\026\f\021\024\021\036 )Tj -0.039 Tw T* [(\023\030\036\022\030\026\013\036\027\017\016 )0.6(\035\036\004\036\027\017\016 )0.5($\r\t\032\017\r\026\036\n\024\f\021\017$ )0.6(\017-\026 )0.5(\203\254 )0.5([16].)]TJ 0.085 Tw T* (\215\024\f\022\024\035\034\022\031 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \016\r\035\016\033\021\f\016 \024\f\027\024\r\027\t\n\017 \017\ \027\020\017\002\017)Tj 0 Tw (-)Tj 0.08 Tw T* [(\021\024\030\026\n\017 )0.5(\205\203\210-\256, )0.6(\023\030\017\n\036\027\016\036\n\t\n\017 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 13.883 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.384 0 Td [(\207\025, )0.5(\024\021)]TJ 0 Tw (-)Tj 0.053 Tw -19.267 -1.218 Td (\f\031\021\f\021\r\017\036 \f\030\026\r\027\017\021\036\035\034\027\t\b \ \217\025\230 \002\t\035\024 \004\026\f\021\017\004\027\024 \022\024\n\023\ \036\027)Tj 0 Tw (-)Tj 0.181 Tw T* (\f\017\030\024\r\026\027\024 \027\036\f\022\024\035\034\022\017\n\017 \030\ \036\026\035\034\027\t\n\017 \017\f\f\035\036\007\024\r\026\027\017\016\n\ \017, )Tj 0.197 Tw T* (\027\026\023\030\026\r\035\036\027\027\t\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\036 \007\r\031\b \206\230\207\215. \200)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, )Tj 0.179 Tw T* (\220\021\017 \007\r\026 \023\030\036\023\026\030\026\021\026 \024\022\026\ \026\035\017\f\034 \024\007\017\027\026\022\024\r\024 \220\235\235\036\022\ \021\017\r)Tj 0 Tw (-)Tj 0.157 Tw T* (\027\t\n\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025. \200)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\023\036\022\021\017\r\027\024\n \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\203\017\007\036\030\035\026\027\007\024\r \f\024\024\002\013\026\035\024\ \f\034 \024)Tj /Span<>> BDC ( )Tj EMC (\f\b\024\007\027\t\b \023\024\022\026)Tj 0 Tw (-)Tj 0.2 Tw T* (\026\021\036\035\016\b \022\035\017\027\017\004\036\f\022\024\020\024 \024\ \021\r\036\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \230\203\205 )Tj T* (\017)Tj /Span<>> BDC ( )Tj EMC (\202\212\202 \031)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\027\026\017\r\027\t\b \023\026\006\017\036\027\021\024\r \207\ \025: \007\024\035\016 \002\024\035\034\027\t\b, )Tj 0.093 Tw T* (\023\030\024\007\024\035\032\026\r\001\017\b \023\030\017\027\017\n\026\021\ \034 \023\030\036\023\026\030\026\021\t, \f\024\f\021\026\r\017\035\026,\ \f\024)Tj 0 Tw (-)Tj -0.042 Tw T* (\024\021\r\036\021\f\021\r\036\027\027\024, 65% \023\030\024\021\017\r 6\ 2% \004\036\030\036 1 \020\024\007 \017)Tj /Span<>> BDC ( )Tj EMC (49% \023\030\024)Tj 0 Tw (-)Tj 0.126 Tw T* (\021\017\r 41% \004\036\030\036 2 \020\024\007\026 [17]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n\031 \017\f\f\035\036\007\024\r\026\027\017\033 )Tj 0.109 Tw T* (\n\024\032\027\024 \020\024\r\024\030\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\024 \027\036\r\t\f\024\022\024\005\ 2-\b \035\036\021)Tj 0 Tw (-)Tj 0.082 Tw T* [(\027\036\005 )0.5(\r\t\032\017\r\026\036\n\024\f\021\017 )0.5(\230\203\205 \017)]TJ /Span<>> BDC ( )Tj EMC 11.219 0 Td [(\202\212\202, )0.5(\021.\022. \022)]TJ /Span<>> BDC ( )Tj EMC 4.727 0 Td [(\220\021\024\n\031 )0.5(\r\030\036\n\036\027\017 )]TJ 0.179 Tw -15.946 -1.218 Td [(\023\030\036\023\026\030\026\021\t \023\030\024\007\024\035\032\026\035\017\ )0.5(\023\030\017\027\017\n\026\021\034 \n\036\027\036\036 \023\024\035\024\r\ \017\027\t )]TJ 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj 0.171 Tw T* (\202\r\f\021\030\017\005\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\ \017\036 2016 \020\024\007\026 \021\026\022\032\036 \027\036 \r\t)Tj 0 Tw (-)Tj 0.155 Tw T* (\016\r\017\035\024 \f\031\013\036\f\021\r\036\027\027\024\005 \030\026\027\ \017\006\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \022\035\017\027\017)Tj 0 Tw (-)Tj 0.032 Tw T* (\004\036\f\022\024\020\024 \024\021\r\036\021\026 \002\036 \206\025 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \017)Tj /Span<>> BDC ( )Tj EMC (2 \035\036\021 \n\036\032\007\031 \202\212\202 )Tj 0.037 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.787 0 Td [(\230\203\205 )0.5(\f\030\036\007\017 )0.6(362 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 11.896 0 Td [(\207\025, )0.5(\027\036 )0.6(\023\024\035\031\004\026\r\001\017\b )0.5(\017\027)]TJ 0 Tw (-)Tj -12.684 -1.218 Td (\020\017\002\017\021\024\030\t \205\203\210-\256 \030\026\027\027\036\036\ [18].)Tj 0.249 Tw T* [(\225\017\006\017\035\017\005\f\022\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.567 0 Td [(\024\f\027\024\r\036 )0.5(\030\036\020\017\f\021\030\026 )0.6(SN )]TJ 0.221 Tw -13.567 -1.218 Td [(IBD, )0.5(\f\030\026\r\027\017\r\026\r\001\036\036 )0.6(\030\036\031\035\034\021\026\021\t )0.5(\035\036\004\036\027\017\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 18.268 0 Td (\002\017\024\027\026\017\r)Tj 0 Tw (-)Tj 0.01 Tw -18.268 -1.218 Td [(\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.574 0 Td [(\027\036 )0.5(\002\017\024\027\026\017\r\027\t\b )0.6(\023\026\006\017\036\027\021\024\r )0.5(\207\025, )0.5(\023\024\035\031\004\026\r\001\017\b )0.6(\202\212\202 )]TJ 0.212 Tw -2.574 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\230\203\205, \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \035\024 \f\024\023\024\f\021\026\r\017\n\031\033 \220\235\235\036\022)Tj 0 Tw (-)Tj 0.244 Tw T* (\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \007\r\031\b \023\030\036\023\026\ \030\026\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b )Tj 0.157 Tw T* (\023\024\007\020\030\031\023\023\026\b \004\036\030\036 1 \020\024\007 \ \027\026\002\035\033\007\036\027\017\016 [19]. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.179 Tw 23.244 64.543 Td (\202\212\202 \031)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\027\026\017\r\027\t\b \023\026\006\017\036\027\021\024\r \220\ \235\235\036\022\021\017\r\027\024\f\021\034 $\f\031\n)Tj 0 Tw (-)Tj 0.126 Tw T* (\n\026 \002\026\035\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n \002\036\f\f\021\036\030\024\017\ \007\027\024\005 \030\036\n\017\f\f\017\017 )Tj 0.239 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026$ \ \f\024\f\021\026\r\017\035\026 69,2%, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj -0.022 Tw T* (\230\203\205 64,5%. \211)Tj /Span<>> BDC ( )Tj EMC (\027\036 \002\017\024\027\026\017\r\027\t\b \002\024\035\034\027\t\b \220\ \021\017 \023\024\022\026\026\021\036\035\017 )Tj -0.008 Tw T* [(\f\024\f\021\026\r\017\035\017, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027\027\024, )0.5(61,7% \017)]TJ /Span<>> BDC ( )Tj EMC [(68,1% )0.5(\002\036 \f\021\026\021\017\f)]TJ 0 Tw (-)Tj 0.005 Tw T* [(\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024\005 \030\026\027\017\006\t. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n )0.5(\220\021\024\020\024 )0.5(\017\f)]TJ 0 Tw (-)Tj 0.061 Tw 0 -1.218 TD (\f\035\036\007\024\r\026\027\017\016 \n\024\032\027\024 \f\031\007\017\021\ \034 \024\002 \024\007\017\027\026\022\024\r\024\005 \220\235\235\036\022\ \021\017\r)Tj 0 Tw (-)Tj 0.028 Tw 0 -1.218 TD (\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \007\r\031\b \024\f\027\024\r\027\t\b \017-\205\203\210, )Tj -0.035 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\005\027\036\005 \n\036\030\036, \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \024\007\027\024\020\024 \020\024\007\026, \ \023\030\017\004\036\n \027\036\026)Tj 0 Tw (-)Tj T* (\r\017\f\017\n\024 \024\021 \023\030\036\007\t\007\031\013\036\020\024 \035\ \036\004\036\027\017\016 \017-\205\203\210.)Tj 0.05 Tw T* [(\224\026 \032\036 )0.5(\f\017\006\017\035\017\005\f\022\026\016 )0.5(\020\030\031\023\023\026 \023\030\024\r\036\035\026 )0.5(\022\024\020\024\030\021\027\024\036 \017\f\f\035\036)]TJ 0 Tw (-)Tj 0.012 Tw T* (\007\024\r\026\027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \f\030\026\r\027\017\r\026\035\017 \220\235\235\ \036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.011 Tw 0 -1.218 TD (\032\017\r\026\036\n\024\f\021\034 \200\213\212\210 \017)Tj /Span<>> BDC ( )Tj EMC (A\212A \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 [20]. \207\t\035\024 \r\022\035\033\004\036\027\024 )Tj 0.091 Tw 0 -1.218 TD [(585 \023\026\006\017\036\027\021\026 )0.6($\200\213\212\210 277; )0.5(A\212A )0.5(308$. \203\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 21.045 0 Td (\021\024, )Tj 0.117 Tw -21.045 -1.218 Td (\004\021\024 \023\024\022\026\026\021\036\035\017 \022\035\017\027\017\004\ \036\f\022\024\020\024 \024\021\r\036\021\026 \002\t\035\017 \004\017\f\035\ \036\027\027\024 )Tj 0.226 Tw 0 -1.218 TD (\r\t\001\036 \007\035\016 A\212A \027\026)Tj /Span<>> BDC ( )Tj EMC (52 \027\036\007\036\035\036 \027\026\002\035\033\007\036\027\017\016, \030\ \026\027\017\006\026 )Tj 0.201 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 \027\036 \002\t\035\026 \f\021\026\021\017\f\021\017\004\ \036\f\022\017 \027\026\004\017\n\024\005 $54% \007\035\016 )Tj -0.036 Tw T* [(\200\213\212\210 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.092 0 Td [(69% )0.5(\007\035\016 )0.6(\202\212\202; )0.5(\210\221 )0.5(0,77 )0.6(\212\230 )0.5(0,45\2261,31 )]TJ /T1_2 1 Tf 0 Tw 14.796 0 Td (\033)Tj /T1_1 1 Tf -0.036 Tw /Span<>> BDC ( )Tj EMC 0.674 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.696 0 Td (0,336$. )Tj 0.47 Tw -19.259 -1.218 Td (\225\031\013\036\f\021\r\036\027\027\024\005 \030\026\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \021\036\030\026\023\017\017 )Tj -0.046 Tw T* [(\n\036\032\007\031 \007\r\031\n\016 )0.5(\023\030\036\023\026\030\026\021\026\n\017 )0.5(\021\026\022\032\036 \027\036 \002\t\035\024 )0.5(\024\002\027\026\030\031\032\036\027\024 )]TJ 0 Tw T* ($\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,20 \212\230 0,83\2261,74 )Tj /T1_2 1 Tf (\033)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,340$.)Tj 0.218 Tw T* [(\237\021\017 )0.5(\r\t\r\024\007\t \002\t\035\017 \r)]TJ /Span<>> BDC ( )Tj EMC 8.937 0 Td [(\006\036\035\024\n \023\024\007\021\r\036\030\032\007\036\027\t )0.5(\007\026\027\027\t\n\017 )]TJ 0.203 Tw -8.937 -1.218 Td [(\025\024\027\f\024\030\006\017\031\n\026 )0.6(VICT)20(OR)-14(Y, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.839 0 Td [(\022\024\021\024\030\024\n )0.5(\f\030\026\r\027\036\027\017\036 )0.6(\n\036\032\007\031 )]TJ -0.001 Tw -10.839 -1.218 Td [(\200\213\212\210 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.162 0 Td [(\026\027\021\017-\205\203\210-\256 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 5.916 0 Td [(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 5.222 0 Td [(\207\025 )0.5(\027\036 )0.5(\023\024\022\026\026\035\024 )0.5(\f\031)]TJ 0 Tw (-)Tj 0.004 Tw -14.3 -1.218 Td (\013\036\f\021\r\036\027\027\024\005 \030\026\027\017\006\t \n\036\032\007\ \031 \007\r\031\n\016 \n\036\021\024\007\026\n\017 \035\036\004\036\027\017\ \016 )Tj 0.129 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \022\035\017\027\017\004\036\f\ \022\024\005 \030\036\n\017\f\f\017\017 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,932, )Tj 0.101 Tw T* (95% \212\230 0,707\2261,228$, \030\036\n\017\f\f\017\017 \002\036 \206\ \025 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,250, )Tj -0.006 Tw T* (95% \212\230 0,677\2262,310$ \017\035\017 \220\027\007\024\f\022\024\023\ \017\004\036\f\022\024\005 \030\036\n\017\f\f\017\017 )Tj -0.084 Tw T* ($\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,827, 95% \212\230 0,595\2261,151$ \004\036\030\036 1 \020\024\007. \224\ \036\030\026\023\017\016 )Tj 0.245 Tw T* (\026\027\021\017-\205\203\210-\256 \002\t\035\026 \026\f\f\024\006\017\017\ \030\024\r\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \r\t\f\024\022\024\005 )Tj 0.047 Tw T* (\r\t\032\017\r\026\036\n\024\f\021\034\033 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210 $508)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005 \007\035\016 )Tj 0.078 Tw T* (\017-\205\203\210 vs 316 \007\027\036\005 \007\035\016 \200\213\212\210$\ , \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \004\026\f\021\024)Tj 0 Tw (-)Tj 0.178 Tw T* (\021\026 \f\036\030\034\036\027\t\b \203\254, \027\024 \027\036 \f\036\030\ \034\036\027\t\b \017\027\235\036\022\006\017\005, \002\t\035\026 )Tj 0.031 Tw T* [(\027\026\004\017\021\036\035\034\027\024 )0.5(\027\017\032\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\017 )0.5(\200\213\212\210 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj 0.23 Tw T* (\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\027\020\017\002\017\021\024\030\026\n\017 \205\203\210-\256 [21]. O\ ster)-15.9(man)]TJ /Span<>> BDC ( )Tj EMC (M.T. )Tj 0.043 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \017\031\004\026\035\017 \f\030\026\r\027\017\021\036\ \035\034\027\031\033 \220\235\235\036\022\021\017\r\027\024\f\021\034 \202\ \212\202 )Tj 0.194 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\230\203\205 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n \023\026\030\026\n\036\021\030\026\n: \r\t\032\017\r\026\036\ \n\024\f\021\034 )Tj 0.179 Tw T* (\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 26 \027\036\007\036\035\034, \004\026\f\021\ \024\021\026 \020\024\f\023\017\021\026\035\017\026)Tj 0 Tw (-)Tj 0.124 Tw T* (\006\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC [(\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ , )0.5(\004\021\024 )]TJ 0.277 Tw T* (\f\026\n\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\036 \023\024\007\030\026\031\n\036\r\026\036\021 \023\030\036\ \022\030\026\013\036\027\017\036 \023\030\017\036\n\026 )Tj 0.291 Tw T* (\023\030\036\023\026\030\026\021\024\r. \225\031\013\036\f\021\r\036\027\ \027\024\005 \030\026\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\f\021\017 \021\036\030\026\023\017\017 \n\036\032\007\031 \023\030\036\023\ \026\030\026\021\026\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 26 \027\036\007\036\035\034 )Tj 0.071 Tw T* [(\r\t\016\r\035\036\027\024 )0.5(\027\036 \002\t\035\024 )0.5($49% )0.5(\230\203\205 vs )0.5(47% \023\026\006\017\036\027\021\024\r )0.5(\202\212\202 )]TJ -0.002 Tw T* (\(\210\221 0,98, 95% \212\230 0,81\2261,19$. \215\030\024\007\035\036\027\ \017\036 \023\036\030\017\024\007\026 \027\026)Tj 0 Tw (-)Tj 0.139 Tw T* (\002\035\033\007\036\027\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (52 \027\036\007\036\035\034 \021\026\022\032\036 \023\024\022\026\026\035\ \024, \004\021\024 \023\030\036\023\026)Tj 0 Tw (-)Tj 0.018 Tw T* (\030\026\021\t \017\n\036\035\017 \f\024\023\024\f\021\026\r\017\n\t\036\ \023\024\022\026\026\021\036\035\017 \r\t\032\017\r\026\036\n\024\f\021\ \017 )Tj -0.03 Tw T* (\021\036\030\026\023\017\017: 31% vs 28% $\210\221 1,08, 95% \212\230 0\ ,86\2261,37$ \002\036 )Tj 0.097 Tw T* (\206\025 \017)Tj /Span<>> BDC ( )Tj EMC (50% vs 49% $\210\221 1,04, 95% \212\230 0,84\2261,28$ \f)Tj /Span<>> BDC ( )Tj EMC (\206\025. )Tj 0.338 Tw T* (\210\020\030\026\027\017\004\036\027\017\036 \027\026\002\035\033\007\036\ \027\017\016 \023\036\030\r\t\n \020\024\007\024\n \f\n\016\020\004\017\035\ \024 )Tj 0.083 Tw T* (\035\033\002\t\036 \030\026\035\017\004\017\016 \n\036\032\007\031 \023\ \030\036\023\026\030\026\021\026\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 )Tj 0.107 Tw T* (\004\026\f\021\024\021\t \b\017\030\031\030\020\017\004\036\f\022\017\b \ \r\n\036\001\026\021\036\035\034\f\021\r $\210\221 0,88, 95% )Tj 0.163 Tw T* (\212\230 0,61\2261,27$. \217\036\031\035\034\021\026\021\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\020\024\f\023\017\021\026\035\017\026\006\017\017 \002\t\035\017 )Tj 0.193 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n \026\027\026\035\024\020\017\004\027\t \030\036\031\035\ \034\021\026\021\026\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 )Tj 0 Tw T* (\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n\031 \r\n\036\001\026\021\036\ \035\034\f\021\r\031 [22].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_3 1 Tf 25 0 0 25 505.552 56.0378 Tm (107)Tj ET endstream endobj 533 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.015 Tw 10 0 0 10 70.8661 724.8299 Tm [(\027\026\002\035\033\007\026\021\036\035\034\027\t\005 \030\036\020\017\f\ \021\030 T)35(ARGET-IBD \017)]TJ /Span<>> BDC ( )Tj EMC (\027\026\004\026\r\001\017\b \023\024)Tj 0 Tw (-)Tj -0.025 Tw 0 -1.218 TD (\035\031\004\026\021\034 \206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\017\033\035\016 2017 \020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\r\020\031\f\021 2020)Tj /Span<>> BDC ( )Tj EMC (\020. )Tj -0.011 Tw T* ([10]. \207\024\035\034\001\026\016 \004\026\f\021\034 \023\026\006\017\036\ \027\021\024\r \002\t\035\026 \002\017\024\027\026\017\r\027\026 $92% )Tj 0.04 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.794 0 Td [(\254\025 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(74% )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\207\025$. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 8.89 0 Td [(\006\036\035\024\n, )0.5(31% \023\026\006\017\036\027\021\024\r )0.5(\023\030\036)]TJ 0 Tw (-)Tj 0.004 Tw -10.684 -1.218 Td (\022\030\026\021\017\035\017 \035\036\004\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\026\035\036 4,1\22618,6 \n\036\f\016\006\036\r \024\ \021 \027\026)Tj 0 Tw (-)Tj 0.197 Tw T* (\004\026\035\026 \021\036\030\026\023\017\017 $\n\036\007\017\026\027\026\ 10,6 \n\036\f\016\006\036\r$. \200\036\030\024\016\021\027\024\f\021\034\ )Tj -0.019 Tw 0 -1.218 TD (\023\030\036\022\030\026\013\036\027\017\016 \021\036\030\026\023\017\017\ \002\t\035\026 \n\036\027\034\001\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \002\024\035\034\027\t\b )Tj 0.033 Tw 0 -1.218 TD (\254\025, \023\024\035\031\004\026\r\001\017\b \200\213\212\210 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005, \023\024\035\031)Tj 0 Tw (-)Tj 0.2 Tw T* [(\004\026\r\001\036\005 )0.5(\017-\205\203\210, \f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\023\030\026\r\022\024\005 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\007\035\017\021\036\035\034\027\024\f\021\034 )0.5(\026\002\024)]TJ 0 Tw (-)Tj 0.126 Tw T* (\035\036\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\023\031\021\f\021\r\031\033\013\036\036 \035\036\004\036\027\017\036\ )0.5(\230\225. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\207\025 \030\017\f\022 )Tj 0.202 Tw T* (\023\030\036\030\t\r\026\027\017\016 \021\036\030\026\023\017\017 \021\026\ \022\032\036 \002\t\035 \027\017\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 )Tj 0.184 Tw T* (\200\213\212\210 \017)Tj /Span<>> BDC ( )Tj EMC (\211\225\224 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017-\205\203\210, \027\024 \030\026\027\017\006\026 \027\036 )Tj 0.029 Tw 0 -1.218 TD (\002\t\035\026 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035)Tj 0 Tw (-)Tj 0.082 Tw 0 -1.218 TD (\027\017\021\036\035\034\027\t\036 \023\026\030\026\n\036\021\030\t $\023\ \024\035, \r\024\030\026\f\021 \027\026\004\026\035\024 \002\024\035\036\ \027\017, )Tj 0.112 Tw 0 -1.218 TD (\027\026\035\017\004\017\036 \f\r\017\013\036\005, \035\024\022\026\035\017\ \026\006\017\033 \023\030\024\006\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\t\007\031)Tj 0 Tw (-)Tj 0.042 Tw T* (\013\031\033 \021\036\030\026\023\017\033 \206\230\207\215$. \224\026\022\ \017\n \024\002\030\026\024\n, \026\027\026\035\017 \023\024\022\026\026\ \035 )Tj 0.046 Tw T* (\007\024\f\021\026\021\024\004\027\024 \027\017\022\031\033 \r\t\032\017\ \r\026\036\n\024\f\021\034 \206\230\207\215, \021.\022. \022\026\032\007\ \t\005 )Tj 0.038 Tw T* (\021\030\036\021\017\005 \023\026\006\017\036\027\021 \200\003\025 \023\030\ \036\022\030\026\013\026\035 \023\030\017\036\n \206\230\207\215 \027\036\ \023\024\007)Tj 0 Tw (-)Tj -0.009 Tw T* (\027\036\036, \004\036\n \004\036\030\036 1,5 \020\024\007\026 $18,6 \n\ \036\f\016\006\036\r$. \200\021\024\030\017\004\027\026\016 \023\024)Tj 0 Tw (-)Tj 0.004 Tw T* (\021\036\030\016 \024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\206\230\207\215 \002\t\035\026 \027\026\017\002\024\035\036\036 \004\026\ \f\021\024\005 \023\030\017\004\017\027\024\005 )Tj 0.022 Tw T* (\023\030\036\030\t\r\026\027\017\016 \021\036\030\026\023\017\017 $31%$\ , \026)Tj /Span<>> BDC ( )Tj EMC (\027\036\005 \f\035\036\007\024\r\026\035\017 \023\024\002\024\004)Tj 0 Tw (-)Tj 0.152 Tw T* [(\027\t\036 \220\235\235\036\022\021\t )0.5($23%$ \017)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\r\017\004\027\024\036 )0.5(\024\021\f\031\021\f\021\r\017\036 )0.5(\024\021\r\036\021\026 )]TJ 0.18 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021 $21%$. \200\t\030\026\002\024\021\022\ \026 \026\027\021\017\021\036\035 $\202\224$ \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036)Tj 0 Tw (-)Tj 0.062 Tw T* (\023\026\030\026\021\031 \023\030\017\r\036\035\026 \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\022\030\026\013\036\027\017\033 \035\036\004\036\027\017\016\ \035\017\001\034 \031)Tj /Span<>> BDC ( )Tj EMC (10% )Tj 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj 0.107 Tw T* (\200 \f\017\f\021\036\n\026\021\017\004\036\f\022\024\n \024\002\024\030\ \036 \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\024\n 449 \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.063 Tw T* [(\r\026\027\017\005 )0.5(\024\006\036\027\017\r\026\035\017 )0.6(\023\030\017\r\036\030\032\036\027\027\024\f\021\034 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 15.429 0 Td [(\035\036\004\036\027\017\033, )0.6(\r\t\032\017)]TJ 0 Tw (-)Tj 0.18 Tw -15.429 -1.218 Td (\r\026\036\n\024\f\021\034, \004\026\f\021\024\021\031 \023\036\030\036\022\ \035\033\004\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\f\022\026\035\026\006\017\017 \206\230\207\215 )Tj -0.001 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.752 0 Td [(\200\003\025 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.499 0 Td (\225\221\202.)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf -0.001 Tw 2.364 0 Td [(\210\f\027\024\r\027\t\n\017 )0.5(\023\030\017\004\017\027\026\n\017 )0.6(\f\027\017\032\036\027\017\016 )0.6(\r\t)]TJ 0 Tw (-)Tj 0.143 Tw -6.616 -1.218 Td (\032\017\r\026\036\n\024\f\021\017 \021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\n\036\027\t \206\230\207\215 $\r \031\002\t\r\026\033\013\036\n\ )Tj 0.082 Tw T* (\023\024\030\016\007\022\036$ \024\022\026\026\035\017\f\034: \027\036\ \007\024\f\021\026\021\024\004\027\026\016 \023\030\017\r\036\030\032\036\ \027\027\024\f\021\034 )Tj 0.07 Tw T* (\023\026\006\017\036\027\021\024\r $\024\021 38% \007\024)Tj /Span<>> BDC ( )Tj EMC (77% \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.099 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \035\017\027\017\017$, \026\021\036\n \023\024\021\036\030\016/\ \027\036\007\024)Tj 0 Tw (-)Tj 0.25 Tw T* (\f\021\026\021\024\004\027\t\005 \024\021\r\036\021, \203\254, \017\027\235\ \036\022\006\017\017 $\023\030\036\017\n\031\013\036\f\021\r\036\027\027\ \024, )Tj 0.082 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f\021\026\030\001\036 60 \035\036\021\ $. \210\021\n\036\027\026 \206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.233 Tw T* (\023\036\030\r\t\b 3-\b \n\036\f\016\006\036\r \026\235\017\022\f\017\030\ \024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (25% \027\026\002\035\033)Tj 0 Tw (-)Tj 0.129 Tw T* (\007\036\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\r \021\036\004\036\027\017\036 1 \020\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (65%. \215\036\030\036\022\035\033\004\036\027\017\036 )Tj 0.291 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \206\230\207\215 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \030\026\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\005 )Tj 0.35 Tw T* (\022\024\035\036\002\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\024\n \017\027\021\036\030\r\026\035\036 4,5\22620%\ , \026)Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.252 Tw T* (\f\021\024\021\026 \220\f\022\026\035\026\006\017\017 \007\024\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \020\024\007\026 \f\024\f\021\026\r\017\035\ \026 )Tj 0 Tw T* (8\22635%)Tj /Span<>> BDC ( )Tj EMC ([11].)Tj 0.307 Tw T* (\217\036\021\030\024\f\023\036\022\021\017\r\027\024 \026\027\026\035\017\ \r\t\032\017\r\026\036\n\024\f\021\017 \206\230\207\215 $\r\f\036\b )Tj 0.095 Tw T* (\017\205\203\210 \017)Tj /Span<>> BDC ( )Tj EMC (\200\213\212\210$ \017)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\t \023\036\030\036\022\035\033\004\036\027\017\016\ )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\026 )Tj 0.123 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021 \017\031\004\026\035\017 \031)Tj /Span<>> BDC ( )Tj EMC (5612 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\207\025 \017)Tj /Span<>> BDC ( )Tj EMC (3533 )Tj 0.247 Tw T* (\023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\254\025 \017)Tj /Span<>> BDC ( )Tj EMC [(\002\026\t \007\026\027\027\t\b T)49.9(r)-21.9(uven Mar)-23.9(k)10(e)-12(t)-35(S)-24(can )]TJ 0.458 Tw T* [(d)42(a)15(t)15(abase, \225\221\202. \225\035\036\007\031\036\021 \024\021\n\036\021\017\ \021\034, \004\021\024 \r)]TJ /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.157 Tw T* [(\023\036\030\r\024\020\024 )0.5(\020\024\007\026 )0.6(\r\t\032\017\r\026\036\n\024\f\021\034 )0.5(\r\f\036\b )0.6(\206\230\207\215 )0.5(\022\026\022 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.811 0 Td (\207\025, )Tj 0.176 Tw -20.811 -1.218 Td (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \254\025 \002\t\035\026 \027\017\022\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021\r\036\021 \f\024\b\030\026\027\017\035\017 \n\036)Tj 0 Tw (-)Tj 0.175 Tw T* (\027\036\036 \023\024\035\024\r\017\027\t \023\026\006\017\036\027\021\024\ \r $48,48%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\020\024\030\021\036 \207\025; )Tj 0.173 Tw T* (44,78%)Tj /Span<>> BDC ( )Tj EMC (\227 \254\025$. \225\026\n\026\016 \r\t\f\024\022\026\016 \r\t\032\017\r\ \026\036\n\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036)Tj 0 Tw (-)Tj 0.234 Tw T* (\004\036\027\017\036 \020\024\007\026 \026\030\036\020\017\f\021\030\017\ \030\024\r\026\027\026 \007\035\016 \202\212\202 $51% \002\024\035\034)Tj 0 Tw (-)Tj 0.168 Tw T* (\027\t\b$, \f\026\n\026\016 \027\017\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \037\213\217\224\210 $35,4% \002\024\035\034\027\t\b$\ , )Tj 0.158 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \n\036\007\017\026\027\026 \r\t\032\017\r\026\036\n\024\f\ \021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\207\025 \f\024\f\021\026\r\017\035\026 )Tj 0.133 Tw T* (\007\035\016 \037\213\217\224\210 \r\f\036\020\024 6)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r, \007\035\016 \202\212\202 1 \020\024\007. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\254\025 )Tj 0.02 Tw 23.244 64.543 Td (\n\036\007\017\026\027\026 \r\t\032\017\r\026\036\n\024\f\021\017 \002\t\ \035\026 \036\013\036 \027\017\032\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\036\002\026\035\026\f\034 )Tj 0.113 Tw T* (\007\035\016 \r\f\036\b \017\205\203\210 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\026\035\036 4\22610)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r)Tj /T1_1 1 Tf 0 Tw (. )Tj /T1_0 1 Tf 0.113 Tw 18.486 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.095 Tw -18.486 -1.218 Td (\007\031\033\013\017\036 \020\024\007\t \023\026\006\017\036\027\021\t, \ \f\024\b\030\026\027\017\r\001\017\036 \024\021\r\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\230\203\205, )Tj 0.002 Tw T* (\023\030\024\007\024\035\032\026\035\017 \036\020\024 \017\f\023\024\035\ \034\024\r\026\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\036\036 \r\t\f\024\022\024\005 \r\036\030\024)Tj 0 Tw (-)Tj 0.087 Tw T* (\016\021\027\024\f\021\034\033 \023\024\021\036\030\017 \024\021\r\036\021\ \026. \217\026\027\027\036\036 \027\026\004\026\035\024 \022\024\n\002\017\ \027\026\006\017\017 )Tj -0.045 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\017\n\n\031\027\024\f\031\023\030\036\f\f\024\030\026\n\017 \f\031\013\036\ \f\021\r\036\027\027\024 )0.5(\031\r\036\035\017\004\017\r\026\035\024 )0.5(\r\t)]TJ 0 Tw (-)Tj -0.041 Tw 0 -1.218 TD (\032\017\r\026\036\n\024\f\021\034 \206\230\207\215 \021\036\030\026\023\ \017\017. \210\f\027\024\r\027\t\n\017 \023\030\036\007\017\022\021\024\030\ \026\n\017 )Tj -0.027 Tw 0 -1.218 TD (\023\030\036\022\030\026\013\036\027\017\016 \035\036\004\036\027\017\016\ \002\t\035\017 \017\027\235\036\022\006\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\020\024\f\023\017\021\026\035\017\026)Tj 0 Tw (-)Tj -0.025 Tw T* [(\006\017\016. )0.5(\202\r\021\024\030\t \023\024\007\004\036\030\022\017\r\026\033\021, )0.6(\004\021\024 \023\024)]TJ /Span<>> BDC ( )Tj EMC 14.3 0 Td [(\023\024\r\024\007\031 )0.5(\200\213\212\210 \017)]TJ /Span<>> BDC ( )Tj EMC 6.237 0 Td (\206\210\214 )Tj 0.224 Tw -20.536 -1.218 Td (\f\035\024\032\027\024 \f\007\036\035\026\021\034 \022\026\022\017\036-\021\ \024 \r\t\r\024\007\t \r\r\017\007\031 \n\026\035\036\027\034\022\024\005\ )Tj 0 Tw T* (\r\t\002\024\030\022\017 [12].)Tj 0.456 Tw T* [(\230\f\f\035\036\007\024\r\026\027\017\036 )0.6(V)37(ARSIT)-71(Y )0.5($\n\027\024\020\024\006\036\027\021\030\024\r\024\036, )0.6(\007\r\024\005\027\024\036 )]TJ 0.098 Tw 0 -1.218 TD (\f\035\036\023\024\036 \217\025\230 III-B \235\026\t \017\n\036\035\024\ \r\026\032\027\024\036 \027\026\004\036\027\017\036, \021.\022. )Tj 0.311 Tw 0 -1.218 TD (\220\021\024 \023\036\030\r\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \036\ \007\017\027\f\021\r\036\027\027\024\036 )Tj 0.105 Tw 0 -1.218 TD [(\023\030\016\n\024\036 \f\030\026\r\027\017\021\036\035\034\027\024\036 \ \(head-t)17(o-head$ \017\f\f\035\036\007\024\r\026\027\017\036 )]TJ 0.097 Tw T* [(\200\213\212\210 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.358 0 Td [(\202\212\202 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.884 0 Td [(\254\025. )0.6(\210\027\024 )0.6(\f\021\026\r\017\035\024 )0.6(\006\036\035\034\033 )0.6(\024\023\030\036\007\036\035\017\021\034 )]TJ 0.091 Tw -7.242 -1.218 Td (\023\030\017\024\030\017\021\036\021\027\024\f\021\034 \024\007\027\024\020\ \024 \017\035\017 \007\030\031\020\024\020\024 \023\030\036\023\026\030\026\ \021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\021\017\032\036\027\017\017 \022\024\027\036\004\027\024\005 \006\036\ \035\017: \023\036\030\r\017\004\027\024\005 \022\024\027\036\004\027\024\ \005 \021\024\004)Tj 0 Tw (-)Tj 0.293 Tw T* [(\022\024\005 V)37(ARSIT)-71(Y \002\t\035\026 \022\035\017\027\017\004\036\f\022\026\016 \030\036\n\017\ \f\f\017\016 \027\026)]TJ /Span<>> BDC ( )Tj EMC (52-\005 )Tj 0.309 Tw T* (\027\036\007\036\035\036, \r\021\024\030\017\004\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \220\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \030\036\n\ \017\f\f\017\016/)Tj -0.013 Tw T* (\031\035\031\004\001\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\f\f\021\036\030\024\017\007\027\026\016 \030\036\n\017\f\f\017\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (52-\005 \027\036\007\036\035\036 )Tj 0.197 Tw T* (\035\036\004\036\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 \023\030\017\027\016\035\017 \ \031\004\026\f\021\017\036 769)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.047 Tw T* (\006\017\036\027\021\024\r $383 \200\213\212\210, 386 \202\212\202$, 2\ 5% \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \030\026\027\036\036 )Tj 0.086 Tw T* [(\023\024\035\031\004\026\035\017 )0.5(\202\212\202 \017\035\017 )0.5(\007\030\031\020\017\036 \017\205\203\210. )0.5(\230\f\f\035\036\007\024\r\026\027\017\036 \023\030\024)]TJ 0 Tw (-)Tj 0.037 Tw T* (\007\036\n\024\027\f\021\030\017\030\024\r\026\035\024 \023\030\017\024\030\ \017\021\036\021 \200\213\212\210 \027\026\007 \202\212\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (52)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.375 Tw T* (\007\036\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \022\035\017\027\017\004\036\f\022\024\ \005 \030\036\n\017\f\f\017\017 $31,3% )Tj 0.1 Tw T* (\023\030\024\021\017\r 22,5%; )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.1 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006$ \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\021\027\024\001\036\027\017\017 \220\027\007\024\f\022\024\023\017\ )Tj 0 Tw (-)Tj 0.109 Tw T* (\004\036\f\022\024\020\024 \031\035\031\004\001\036\027\017\016 $39,7% \ \023\030\024\021\017\r 27,7%, )Tj /T1_2 1 Tf 0 Tw (\033)Tj /T1_0 1 Tf 0.109 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001$, )Tj 0.111 Tw T* (\027\024 \027\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\021\017\032\036\027\017\017 \002\036\f\021\036\030\024\017\007\ \027\024\005 \030\036\n\017\f\f\017\017 $12,6% )Tj 0.034 Tw T* (\023\030\024\021\017\r 21,8% \002\036 \f\021\026\021\017\f\021\017\004\036\ \f\022\017 \027\026\004\017\n\024\005 \030\026\027\017\006\t$. )Tj 0.098 Tw T* (\212\024\f\021\024\r\036\030\027\t\b \030\026\035\017\004\017\005 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \203\254, \023\030\036\032\007\036 \r\f\036\020\ \024 )Tj 0.167 Tw T* (\f\036\030\034\036\027\t\b \017\027\235\036\022\006\017\005, \021\026\022\ \032\036 \r\t\016\r\035\036\027\024 \027\036 \002\t\035\024 $1,6 )Tj 0.349 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (2,2 \f\035\031\004\026\016/ 100)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024-\035\036\021, \f\024\024\021\r\036\021\f\ \021\r\036\027\027\024$. )Tj 0.009 Tw T* (\224\026\022\017\n \024\002\030\026\024\n, \200\213\212\210 \023\030\036\ \r\024\f\b\024\007\017\021 \202\212\202 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.105 Tw T* (\027\024\f\021\017, \027\024 \027\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\n \022\024\027\036\004\027\t\n \023\026\030\026\n\036\021\030\026\ \n. \210\007\027\026\022\024 )Tj 0.094 Tw T* (\020\024\r\024\030\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 \r\t\032\017\r\026\036\n\024\f\021\017 \024\007\ \027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026)Tj 0 Tw (-)Tj -0.052 Tw T* (\030\026\021\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \017\f\f\035\036\007\024\r\026\027\ \017\016 \007\026\032\036 \022\024\f\r\036\027\027\024 \027\036 )Tj 0.053 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021\f\016 \r\024\n\024\032\027\ \t\n, \023\024\f\022\024\035\034\022\031 \007\017\026\005\027\024\n \017\ \f)Tj 0 Tw (-)Tj -0.053 Tw T* [(\f\035\036\007\024\r\026\027\017\016 )0.5(\220\021\024 \027\036 )0.5(\023\030\036\007\031\f\n\024\021\030\036\027\024, \026)]TJ /Span<>> BDC ( )Tj EMC 14.938 0 Td (\f\030\024\022 \027\026\002\035\033\007\036\027\017\016 )Tj 0 Tw -14.938 -1.218 Td (\002\t\035 \024\020\030\026\027\017\004\036\027 1 \020\024\007\024\n \007\ \035\016 \024\002\024\017\b \023\030\036\023\026\030\026\021\024\r)Tj /Span<>> BDC ( )Tj EMC ([13].)Tj 0.061 Tw T* (\200 \030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \024\007\027\ \024\006\036\027\021\030\024\r\024\n \235\030\026\027\006\031\f\022\024\ \n \017\f)Tj 0 Tw (-)Tj 0.126 Tw T* (\f\035\036\007\024\r\026\027\017\017, \022\024\021\024\030\024\036 \023\030\ \024\r\024\007\017\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 16 \035\036\021, )Tj 0.248 Tw T* (\002\t\035\017 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \027\t \f\b\024\032\017\036 \023\024\022\026\026\021\036\035\017 \r\t)Tj 0 Tw (-)Tj 0.225 Tw T* (\032\017\r\026\036\n\024\f\021\017 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC (A\212A \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\005 \035\017\027\017\017 )Tj 0.268 Tw T* (\021\036\030\026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025 [14]. \225\030\036\007\027\016\016 \007\035\017\021\036\035\034\ \027\024\f\021\034 \021\036\030\026)Tj 0 Tw (-)Tj 0.045 Tw T* (\023\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\021\036\030\017 \024\021\r\036\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \035\017\027\017\017 \f\024\f\021\026\r\017\035\026 3,4 \020\024\007\ \026 )Tj 0.011 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (2,1)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\026 \007\035\016 \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC [(\202\212\202, )0.5(\f\024\024\021\r\036\021\f\021\r\036\027\027\024, \002\036 \007\024\f\021\ \024)]TJ 0 Tw (-)Tj 0.083 Tw T* (\r\036\030\027\t\b \030\026\035\017\004\017\005. \200\024 2-\005 \035\017\ \027\017\017 \r\t\032\017\r\026\036\n\024\f\021\034 \002\t\035\026 )Tj 0.108 Tw T* [(\026\027\026\035\024\020\017\004\027\026: )0.5(2,0 \017)]TJ /Span<>> BDC ( )Tj EMC (3,2 \020\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\030\031\023\023\026\b \230\203\205 \017)Tj /Span<>> BDC ( )Tj EMC 20.406 0 Td (\202\212\202 )Tj 0 Tw -20.406 -1.218 Td (\f\024\024\021\r\036\021\f\021\r\036\027\027\024.)Tj 0.262 Tw T* (\225\030\026\r\027\036\027\017\036\n \220\235\235\036\022\021\017\r\027\024\ \f\021\017 \030\026\027\t\b \206\230\207\215 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 )Tj 0.329 Tw T* (\026\022\021\017\r\027\024 \026\027\017\n\026\035\026\f\034 \f\017\006\017\ \035\017\005\f\022\026\016 \020\030\031\023\023\026 \017\f\f\035\036\007\ \024)Tj 0 Tw (-)Tj 0.227 Tw T* (\r\026\021\036\035\036\005, \017\f\023\024\035\034\031\016 \f\017\006\017\ \035\017\005\f\022\017\005 \030\036\020\017\f\021\030 $SN IBD$. )Tj -0.023 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\005 \f\030\026\r\027\017\r\026\035\ \017 \220\235\235\036\022\021\017\r\027\024\f\021\034 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_4 1 Tf 25 0 0 25 20.7776 56.0378 Tm (106)Tj ET endstream endobj 40 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 41 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 42 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 43 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 44 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 546 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 289.5098 42.7216 Tm [(Compar)21(ativ)12.1(e ef)-31(f)-21(icacy and sur)-21(viv)10(al of\022biologics in inflammator)-31(y bow)11(el )]TJ -0.033 -1 Td [(disease in dif)-30.9(fer)31(ent lines of\022th)11(er)21.1(apy: th)11(e\022clinician\226)63(s vie)11(w of\022th)11(e pr)20(oblem)]TJ -32.899 1 Td [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-10(\026\n \b\022\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-\b\t\235\f\t\f\017\t\240\002 )]TJ 0 -1 TD [(\210\b\025\013\025\020\b\213\f\205\007\b\002 \223\017\f\223\005\017\005\026\ )11(\025\016 $\031\030\214\034$ \223\017\b\022\016\025\205\223\005\013\b\026\ )11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 )]TJ T* [(\007\b\203\f\213\t\b\007\005 \016\022\017\005\001\t\240\002 \013\b\t\b\002\ \026)11(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-10(\013\b\t\b\216\b\205)-9.9(\026)11(\005 \t\005\022\223\017\025\210\013\f\024\220)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.179 Tw 10 0 0 10 42.5197 724.8299 Tm (\027\026\027\026\004\036\027\017\016 \206\230\207\215 \007\024)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \023\030\036\022\030\026\013\036\027\017\016 \023\ \030\017\036\n\026 )Tj 0.147 Tw 0 -1.218 TD (\023\030\036\023\026\030\026\021\026, \023\024\021\036\030\017 \024\021\r\ \036\021\026 \017\035\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \023\036\030\036\022\035\033)Tj 0 Tw (-)Tj 0.169 Tw T* (\004\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005 \023\030\036\023\026\030\026\021. \237\021\024 \ \023\026\030\026\n\036\021\030, \024\021\030\026\032\026\033)Tj 0 Tw (-)Tj 0.165 Tw T* [(\013\017\005 )0.5(\021\036\030\026\023\036\r\021\017\004\036\f\022\031\033 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034, )0.6(\002\036\024\023\026\f\027\024\f\021\034 )]TJ 0.16 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\036\030\032\036\027\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\035\034\027\024\005 \022\035\017\027\017\004\036\f\022\024\005\ )Tj 0 Tw T* (\023\030\026\022\021\017\022\036 [4].)Tj 0.354 Tw 0 -1.218 TD (\210\006\036\027\022\026 \r\t\032\017\r\026\036\n\024\f\021\017 \206\230\ \207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \023\030\017\004\017\027 \036\036 )Tj 0.06 Tw 0 -1.218 TD (\f\027\017\032\036\027\017\016 \016\r\035\016\033\021\f\016 \031\007\024\ \002\027\t\n \017\027\f\021\030\031\n\036\027\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017)Tj 0 Tw (-)Tj 0.212 Tw T* (\n\t\n \235\026\022\021\024\030\024\n \023\024\r\t\001\036\027\017\016 \220\ \235\235\036\022\021\017\r\027\024\f\021\017 \035\036\004\036\027\017\016\ )Tj 0 Tw T* (\200\003\025)Tj /Span<>> BDC ( )Tj EMC ([5].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 578.6938 Tm (\017\034\r\236)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.017 Tw 10 0 0 10 42.5197 554.3378 Tm (\202\027\026\035\017 \023\031\002\035\017\022\026\006\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\026 \021\036\022\031\013\036\020\024 \f\024\f\021\024\ \016\027\017\016 \r\024)Tj 0 Tw (-)Tj 0.077 Tw T* (\023\030\024\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\024\005 \220\235\235\036\022\021\ \017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036)Tj 0 Tw (-)Tj 0.146 Tw T* (\n\024\f\021\017 \206\230\207\215 \030\026\027\t\b \022\035\026\f\f\024\ \r \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\020\036\021\027\t\b \017\n\n\031\027\024\f\031)Tj 0 Tw (-)Tj T* (\023\030\036\f\f\024\030\024\r $\224\230\225$ \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \035\017\027\017\016\b \021\036\030\026\023\017\017 \200\ \003\025.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 481.2698 Tm [(\240)21(\026)45(\024\034\033\031\026)-10(\r\232)5( \031)5(\016)-18.3(\240\034)-31(\024)35(\037\226\232)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.565 Tw 10 0 0 10 42.5197 456.9138 Tm (\215\024\017\f\022 \023\031\002\035\017\022\026\006\017\005 \023\030\024\ \r\024\007\017\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\002\026\026\b \007\026\027\027\t\b )Tj -0.014 Tw T* [(PUBMED, )0.5(MEDLINE, )0.6(EMBA)35(SE )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.876 0 Td [(Co)-16(chr)-33(ane )0.5(L)-32(ibr)-32.9(ar)-24(y )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 7.678 0 Td (2013\226)Tj -0.094 Tw -19.554 -1.218 Td (2024)Tj /Span<>> BDC ( )Tj EMC (\020\020. \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\n \f\035\024\r\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\235\030\026\026\n \233In\257)-16(amma)15.1(t)17(or)-24(y )]TJ 0.115 Tw T* [(bo)-14(wel disease, ul)16(cer)-32.9(a)15(t)-32(i)-16(ve col)-31(i)-24(t)-31.9(is, Cr)-31.9(ohn\241s disease, bio)]TJ 0 Tw (-)Tj 0.031 Tw T* [(l)30(o)-16(gics sur)-31.9(v)-16(i)-16(v)-15(al/per)-9.9(sistence, com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve ef\251ca)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC (bi)Tj 0 Tw (-)Tj 0.028 Tw T* [(ol)30(o)-16(gics, biol)30.1(o)-16(gics immuno)-16(genic)-23.9(i)-24(t)-10(y. \200)]TJ /Span<>> BDC ( )Tj EMC (\030\024\f\f\017\005\f\022\024\005 \002\026\036 )Tj 0.084 Tw T* (\007\026\027\027\t\b \217\230\203\037 \023\024\007\024\002\027\t\b \023\031\ \002\035\017\022\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\n \032\036 \022\035\033)Tj 0 Tw (-)Tj T* (\004\036\r\t\n \f\035\024\r\026\n \027\026\005\007\036\027\024 \027\036 \ \002\t\035\024.)Tj /T1_3 1 Tf 0 -2.436 TD (\200\006\t\b\204\t\212\013 \214\r\240\t\220\004\214\r\b\003\002\213\b\002\ \005 \003\r\006\004\212\t\t \026\033\021)Tj /T1_1 1 Tf 0.02 Tw 0 -1.218 TD (\025 \002\026\017\f\027\024\005 \021\036\030\026\023\017\017 \200\003\025\ \024\021\027\024\f\016\021\f\016 \023\030\036\023\026\030\026\021\t 5-\026\ \n\017)Tj 0 Tw (-)Tj 0.104 Tw T* [(\027\024\f\026\035\017\006\017\035\024\r\024\005 )0.6(\022\017\f\035\024\021\t )0.5($5-\202\225\025$, )0.6(\017\n\n\031\027\024\f\031\023\030\036\f\f\024\030\t )]TJ 0.13 Tw T* ($\230\225$, \020\035\033\022\024\022\024\030\021\017\022\024\017\007\t\ $\206\025$ [4,6]. \206\230\207\215 \017)Tj /Span<>> BDC ( )Tj EMC (\224\230\225 \023\030\017)Tj 0 Tw (-)Tj 0.096 Tw T* (\n\036\027\016\033\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \017\035\017 \027\ \036\023\036\030\036\027\024\f\017\n\024\f\021\017 )Tj 0.109 Tw T* (\002\026\017\f\027\024\005 \021\036\030\026\023\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \030\036\235)Tj 0 Tw (-)Tj 0.154 Tw T* (\030\026\022\021\036\030\027\t\b \235\024\030\n \200\003\025, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \f\021\036)Tj 0 Tw (-)Tj 0.354 Tw T* (\030\024\017\007\024\026\r\017\f\017\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\030\024\017\007\024\030\036\017\f\021\036\027\021\027\024\f\021\ \017. \212\035\016 )Tj 0.019 Tw T* (\035\036\004\036\027\017\016 \200\003\025 \026\030\036\020\017\f\021\030\ \017\030\024\r\026\027\t \023\030\036\023\026\030\026\021\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 )Tj 0.192 Tw T* (\n\024\027\024\022\035\024\027\026\035\034\027\t\b \026\027\021\017\021\036\ \035 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n \023\030\024\r\024\f\023\026\035\017)Tj 0 Tw (-)Tj 0.322 Tw T* (\021\036\035\034\027\t\n \006\017\021\024\022\017\027\026\n: \017\027\020\ \017\002\017\021\024\030\t \235\026\022\021\024\030\026 \027\036\022\030\ \024\026 )Tj -0.036 Tw T* (\024\023\031\b\024\035\017-\026\035\034\235\026 $\017\205\203\210-\256$\ : \017\027\235\035\017\022\f\017\n\026\002 $\230\203\205$ \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\026)Tj 0 Tw (-)Tj 0.047 Tw T* (\035\017\n\031\n\026\002 $\202\212\202$ \007\035\016 \254\025 \017)Tj /Span<>> BDC ( )Tj EMC (\207\025, \020\024\035\017\n\031\n\026\002 $\206\210\214$ \021\024\035\ \034\022\024 )Tj 0.029 Tw T* (\007\035\016 \254\025 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\030\021\024\035\017\031\n\026\002\026 \023\220\020\024\035 $\037\ \213\217\224$ \021\024\035\034\022\024 \007\035\016 \207\025. )Tj 0.081 Tw T* (\225\036\035\036\022\021\017\r\027\024 \007\036\005\f\021\r\031\033\013\017\ \005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022 \002\035\024\022\026\021\024\030 \017\027\ )Tj 0 Tw (-)Tj 0.071 Tw T* (\021\036\020\030\017\027\026 \2564\2637 $\r\036\007\024\035\017\031\n\026\ \002)Tj /Span<>> BDC ( )Tj EMC (\227 \200\213\212\210$ \026\030\036\020\017\f\021\030\017\030\024)Tj 0 Tw (-)Tj 0.138 Tw T* (\r\026\027 \007\035\016 \024\002\024\017\b \026\002\024\035\036\r\026\027\ \017\005, \021\026\022\032\036 \022\026\022 \031\f\021\036\022\017\027\031\ \n\026\002 )Tj 0.023 Tw T* ($\211\225\224$, \023\030\036\007\f\021\026\r\035\016\033\013\017\005 \f\ \024\002\024\005 \n\024\027\024\022\035\024\027\026\035\034\027\t\036 \026\ \027\021\017)Tj 0 Tw (-)Tj 0.106 Tw T* [(\021\036\035\026 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 2.923 0 Td [(\f\031\002\255\036\007\017\027\017\006\036 )0.5(\21740 \017\027\021\036\030\035\036\005\022\017\027\024\r )0.6(12/23 [7,8]. )]TJ 0.155 Tw -2.923 -1.218 Td (\025\030\024\n\036 \021\024\020\024, \007\035\016 \035\036\004\036\027\017\ \016 \200\003\025 \023\030\017\n\036\027\016\033\021\f\016 \224\230\225,\ \024\021)Tj 0 Tw (-)Tj 0.168 Tw T* [(\027\024\f\016\013\017\036\f\016 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 5.753 0 Td [(\022\035\026\f\f\031 )0.5(\017\027\020\017\002\017\021\024\030\024\r )0.5(\016\027\031\f-\022\017\027\026 )0.6($J)15(AK$. )]TJ -0.039 Tw -5.753 -1.218 Td (\203\026)Tj /Span<>> BDC ( )Tj EMC 1.267 0 Td [(\030\024\f\f\017\005\f\022\024\n )0.5(\030\t\027\022\036 )0.6(\024\027\017 )0.5(\023\030\036\007\f\021\026\r\035\036\027\t )0.5(\021\024\235\026\006\017\021\017\027\017)]TJ 0 Tw (-)Tj -0.029 Tw -1.267 -1.218 Td (\002\024\n $\224\210\205\202$ \007\035\016 \035\036\004\036\027\017\016\ \021\024\035\034\022\024 \254\025 \017)Tj /Span<>> BDC ( )Tj EMC (\031\023\026\007\024\006\017\021\017\027\017\002\024\n )Tj 0.116 Tw 23.244 64.543 Td ($\211\215\202$, \017\f\023\024\035\034\031\036\n\t\n \022\026\022 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\254\025, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \207\025. \200\f\036 )Tj 0.199 Tw 0 -1.218 TD (\031\022\026\026\027\027\t\036 \f\030\036\007\f\021\r\026 \007\036\005\f\ \021\r\031\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\031 \024\023\030\036\007\036\035\036\027)Tj 0 Tw (-)Tj 0.28 Tw 0 -1.218 TD (\027\031\033 \n\017\001\036\027\034 $\f\r\024\002\024\007\027\t\005 \006\ \017\021\024\022\017\027 \017\035\017 \f\023\036\006\017\235\017\004\036\ )Tj 0 Tw (-)Tj 0.049 Tw 0 -1.218 TD (\f\022\017\005 \022\035\036\021\024\004\027\t\005/\r\027\031\021\030\017\ \022\035\036\021\024\004\027\t\005 \030\036\006\036\023\021\024\030$, \017\ \020\030\026\033)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\013\031\033 \027\026\004\017\n\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026\f\022\026\007\036 \r\024\f\023\026\035\036\027\017\016 [4,6], \004\ \021\024 )Tj 0.066 Tw 0 -1.218 TD (\024\021\035\017\004\026\036\021 \220\021\017 \n\024\027\024\021\026\030\ \020\036\021\027\t\036 \023\030\036\023\026\030\026\021\t \024\021 \002\026\ \017\f\027\t\b, )Tj 0.213 Tw 0 -1.218 TD (\017\n\036\033\013\017\b \n\031\035\034\021\017\021\026\030\020\036\021\027\ \024\036 \007\036\005\f\021\r\017\036. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.27 Tw 0 -1.218 TD (\007\024\f\021\026\021\022\024\n \023\030\016\n\t\b \022\035\017\027\017\ \004\036\f\022\017\b \017\f\023\t\021\026\027\017\005 \007\026\027\027\t\ \036 )Tj 0.525 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\021\036\035\034\027\024\005 \220\235\235\036\022\021\ \017\r\027\024\f\021\017 \206\230\207\215 \024\f\021\026\033\021\f\016 )Tj 0.224 Tw T* (\027\036\016\f\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\030\036\004\017\r\t\n\017. \237\021\024\021 \017\ \027\235\024\030\n\026\006\017\024\027)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\t\005 \023\030\024\002\036\035 \026\f\021\026\r\035\016\036\021 \f\ \023\036\006\017\026\035\017\f\021\024\r \017\f\022\026\021\034 \007\024\ \023\024\035)Tj 0 Tw (-)Tj 0.269 Tw T* (\027\017\021\036\035\034\027\t\036 \007\024\022\026\026\021\036\035\034\ \f\021\r\026 \007\035\016 \027\026\017\035\031\004\001\036\020\024 \r\t\002\ \024\030\026 )Tj 0 Tw T* (\206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ .)Tj /T1_3 1 Tf 0.272 Tw 0 -2.436 TD (\022\r\004\f\001\b\004\235 \002\204\r\b\220\004 \224\230\230\r\220\003\t\ \b\002\217\003\t \t)Tj /Span<>> BDC ( )Tj EMC (\013\202\t\004\r\214\002)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\217\003\t \006\235\240\004 \220\f\004\217\217\002 \027\034\225\200 )Tj /Span<>> BDC ( )Tj EMC (\006\004\213\b\013\216 \f\t\b\t\235\216 \003\r\006\004\212\t\t )Tj 0 Tw T* (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\026\033\021)Tj /T1_1 1 Tf 0.101 Tw T* (\212\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\024\030\017\021\036\021\027\024\f\021\017 \027\026\027\026\ \004\036\027\017\016 \206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030)Tj 0 Tw (-)Tj 0.417 Tw T* (\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\b \035\017\027\017\016\b \021\036\ \030\026\023\017\017 \024\020\030\026\027\017\004\036\027\t )Tj 0.13 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\036\f\034\n\026 \023\030\024\021\017\r\024\030\036\004\017\r\t. \207\t\ \035\024 \023\030\024\r\036\007\036\027\024 \027\036\f\022\024\035\034)Tj 0 Tw (-)Tj 0.277 Tw T* (\022\024 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \022\035\ \017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005\ )Tj 0.333 Tw T* ($\217\025\230$ \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\024\020\024\030\021\027\t\b \017\f\f\035\036)Tj 0 Tw (-)Tj 0.435 Tw T* (\007\024\r\026\027\017\005, \f\030\026\r\027\017\r\026\033\013\017\b \023\ \030\024\235\017\035\017 \220\235\235\036\022\021\017\r\027\024\f\021\017\ , )Tj 0.25 Tw T* (\002\036\024\023\026\f\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\032\017\r\026\036\n\024\f\021\017 )0.5(\206\230\207\215. \210\023\030\036\007\036\035\036\027\017\036 )]TJ /T1_4 1 Tf 0.094 Tw T* (\253\036\032\003\022\036\037\016\b\034\024\035\022 \035\016\033\037\f\022\ \022\273)Tj /T1_3 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.094 Tw 11.627 0 Td (\023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \023\030\ \024)Tj 0 Tw (-)Tj 0.183 Tw -11.627 -1.218 Td [(\f\021\024\005 \022\024\f\r\036\027\027\t\005 )0.5(\023\024\007\b\024\007 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\036 \007\024\035\020\024\f\030\024\004\027\024\005 \ )0.5(\021\036)]TJ 0 Tw (-)Tj 0.198 Tw T* (\030\026\023\036\r\021\017\004\036\f\022\024\005 \220\235\235\036\022\021\ \017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\235\017\035\016 \002\036\024\023\026\f)Tj 0 Tw (-)Tj 0.214 Tw T* (\027\024\f\021\017. \212\026\027\027\t\005 \023\024\007\b\024\007 \023\030\ \036\007\023\024\035\026\020\026\036\021, \004\021\024 \023\026\006\017\036\ \027\021\t )Tj 0.308 Tw T* (\023\030\024\007\024\035\032\026\033\021 \017\f\023\024\035\034\024\r\026\ \021\034 \206\230\207\215 \007\035\016 \023\024\007\007\036\030\032\026\027\ \017\016 )Tj 0.432 Tw T* (\007\024\f\021\017\020\027\031\021\024\005 \022\035\017\027\017\004\036\f\ \022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \030\036)Tj 0 Tw (-)Tj 0.331 Tw T* (\n\017\f\f\017\017 \002\036 \f\027\017\032\036\027\017\016 \220\235\235\ \036\022\021\017\r\027\024\f\021\017 \017\035\017 \023\024\021\036\030\017\ )Tj 0.092 Tw T* (\024\021\r\036\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \b\024\030\024\001\036\005 \023\036\030\036\027\ \024\f\017)Tj 0 Tw (-)Tj 0.175 Tw T* (\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\016 \023\024\002\024\004\027\t\b \220\235\ \235\036\022\021\024\r. \025)Tj /Span<>> BDC ( )Tj EMC (\f\024\032\026\035\036)Tj 0 Tw (-)Tj 0.16 Tw T* (\027\017\033, \023\030\026\022\021\017\004\036\f\022\017 \022\024 \r\f\036\ \n \206\230\207\215 \024\021\r\036\021 \f\024 \r\030\036\n\036\027\036\n\ )Tj 0.191 Tw T* (\021\036\030\016\036\021\f\016. \210\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027 \023\024\021\036\030\017 \024\021\r\036\021\026\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\206\230\207\215 )Tj 0.404 Tw T* (\016\r\035\016\036\021\f\016 \017\n\n\031\027\024\020\036\027\027\024\f\021\ \034,)Tj /T1_4 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 11.839 0 Td (\021.\036.)Tj /T1_4 1 Tf ( )Tj /T1_1 1 Tf 0.404 Tw 2.076 0 Td (\r\t\030\026\002\024\021\022\026 \026\027\021\017\021\036\035 )Tj 0.175 Tw -13.915 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\026\030\026\021\031, \004\021\024 \f\027\017\032\026\036\ \021 \017\035\017 \027\036\005\021\030\026\035\017\031\036\021 \036\020\ \024 \021\036)Tj 0 Tw (-)Tj 0.135 Tw T* (\030\026\023\036\r\021\017\004\036\f\022\024\036 \007\036\005\f\021\r\017\ \036. \025\030\024\n\036 \023\024\021\036\030\017 \024\021\r\036\021\026\ , \007\030\031)Tj 0 Tw (-)Tj 0.22 Tw T* (\020\017\036 \023\030\017\004\017\027\t \023\030\036\022\030\026\013\036\ \027\017\016 \023\030\017\036\n\026 \206\230\207\215 \r\022\035\033\004\026\ \033\021 )Tj 0.352 Tw T* (\027\017\022\031\033 \022\024\n\023\035\026\036\027\021\027\024\f\021\034\ \023\026\006\017\036\027\021\024\r $\027\036\f\024\002\035\033\007\036\ \027\017\036 )Tj 0.033 Tw T* (\030\036\022\024\n\036\027\007\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\036\n\031 \023\030\036\023\026\030\026\021\024\r$ \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\032\036\035\026\021\036\035\034)Tj 0 Tw (-)Tj 0.106 Tw T* (\027\t\036 \016\r\035\036\027\017\016 $\203\254$, \021\026\022\017\036\ \022\026\022 \017\027\235\031\017\024\027\027\t\036 \030\036\026\022\006\ \017\017, )Tj 0.227 Tw T* (\017\027\235\036\022\006\017\017 \017\035\017 \022\035\026\f\f-\f\023\036\ \006\017\235\017\004\036\f\022\017\036 \023\024\002\024\004\027\t\036 \220\ \235)Tj 0 Tw (-)Tj 0.586 Tw T* (\235\036\022\021\t [1,2,5,7,8,9]. \212\024\023\024\035\027\017\021\036\035\ \034\027\t\n\017 \235\026\022\021\024\030\026\n\017 )Tj 0.101 Tw T* (\023\030\036\022\030\026\013\036\027\017\016 \023\030\017\036\n\026 \023\ \030\036\023\026\030\026\021\026 \n\024\020\031\021 \002\t\021\034 \026\007\ \n\017\027\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\f\021\030\026\021\017\r\027\t\036, \027\036 \n\036\007\017\006\017\027\f\ \022\017\036 \023\030\017\004\017\027\t $\024\f\024\002\036\027\027\024\ \f\021\017 )Tj 0.32 Tw T* (\026\022\024\027\024\007\026\021\036\035\034\f\021\r\026, \024\021\f\031\ \021\f\021\r\017\036 \023\030\036\023\026\030\026\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\t\027\022\036, )Tj 0.331 Tw T* (\024\021\f\031\021\f\021\r\017\036 \017\027\r\026\035\017\007\027\024\f\021\ \017, \027\036\023\024\035\027\024\036 \f\021\030\026\b\024\r\024\036 \023\ \024)Tj 0 Tw (-)Tj T* (\022\030\t\021\017\036 \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030.$ [1,2,5,7,8,9].)Tj 0.159 Tw T* (\210\007\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\031\023\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 \r\t\032\017\r\026)Tj 0 Tw (-)Tj 0.147 Tw T* (\036\n\024\f\021\017 \206\230\207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\035\034\027\024\005 \022\024\020\024\030\021\036 \002\024\035\ \034\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024)Tj 0 Tw (-)Tj 0.237 Tw T* (\030\024\r, \027\026)Tj /Span<>> BDC ( )Tj EMC [(\027\036\036 \r\035\017\016\033\013\017\b, \002\t\035\024 \023\030\024\r\ \036\007\036\027\024 Ed)-17(w)-11.9(ar)-24(d)]TJ /Span<>> BDC ( )Tj EMC (B. )Tj 0.194 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \007\026\027\027\t\b 856 \023\026\006\017\036\027\ \021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\200\003\025 )Tj -0.012 Tw T* ($39%)Tj /Span<>> BDC ( )Tj EMC (\227 \254\025, 61%)Tj /Span<>> BDC ( )Tj EMC (\227 \207\025$, \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\n\036\030\017\022\026\027\f\022\017\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4397 56.0378 Tm (105)Tj ET endstream endobj 545 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 500.8534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 500.8534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 463.6456 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 463.6456 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 409.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.06 Tw 9 0 0 9 119.0551 730.4919 Tm [(AIM: to analyze publications and assess the cur)-15.9(rent state of the issue on the com)16(parativ)13(e ef)-40(f)-43(icacy and sur)-42(viv)16(al of )]TJ 0.023 Tw 0 -1.111 TD [(dif)-40(ferent classes and dif)-40(ferent lines of biological therap)12(y for inf)-22(lammator)-42.9(y bow)12(el diseases $IBD$)]TJ 0.061 Tw T* [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: the search for publications w)13(as done in the PUBMED, MEDLINE, EMB)20(A)50(SE d)26(atabases and )]TJ -0.029 Tw T* [(Cochrane Librar)-42.9(y from 2013 to 2024 using k)17(ey w)12(ords and phrases \242Inf)-22(lammator)-43(y bow)12(el disease\243, \242ulcerativ)12.9(e colitis\243, )]TJ 0.1 Tw T* [(\242Crohn)24(\245)37(s disease\243, \242biologics sur)-42(viv)16(al/persistence\243, \242com)16.1(parativ)13(e ef)-40(f)-42.9(icacy of biologics in dif)-39.9(ferent therap)11.9(y lines\243, )]TJ 0.023 Tw 0 -1.111 TD [(\242biologics\243, \242immunog)12.1(enicity\243.)]TJ 0.174 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: loss of)]TJ /Span<>> BDC ( )Tj EMC [(response ov)13(er time is obser)-41.9(v)13(ed for all biologic ag)12(ents. The)]TJ /Span<>> BDC ( )Tj EMC (choice of)Tj /Span<>> BDC ( )Tj EMC [(the f)-43(irst biologic ag)12(ent )]TJ 0.105 Tw T* [(may af)-40(fect the)]TJ /Span<>> BDC ( )Tj EMC [(ef)-40(f)-43(icacy of)]TJ /Span<>> BDC ( )Tj EMC [(subseq)14(uent lines of)]TJ /Span<>> BDC ( )Tj EMC [(therap)12.1(y)32(. TNF inhibitors are most of)-46(ten p)46(rescr)-37(ibed in the)]TJ /Span<>> BDC ( )Tj EMC [(f)-43(irst line )]TJ 0.027 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(therap)12(y)42(, but their sur)-42(viv)16(al in IBD is low)12(er com)16(pared to)]TJ /Span<>> BDC ( )Tj EMC [(biologic ag)12(ents of)]TJ /Span<>> BDC ( )Tj EMC [(o)13(ther classes: half of)]TJ /Span<>> BDC ( )Tj EMC (the patients loses )Tj 0.025 Tw T* [(response )0.5(af)-46(ter )0.5(1\2262)]TJ /Span<>> BDC ( )Tj EMC 7.604 0 Td [(years. )0.5(Switching )0.5(within )0.5(one )0.5(class )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 14.223 0 Td [(biologic )0.5(ag)12(ents )0.5($TNF inhibitors$ )0.5(reduces )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 17.512 0 Td [(ef)-40(f)-43(icacy of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0.006 Tw -39.338 -1.111 Td (second line of)Tj /Span<>> BDC ( )Tj EMC [(therap)12.1(y)32(. The)]TJ /Span<>> BDC ( )Tj EMC [(sur)-42(viv)16(al of)]TJ /Span<>> BDC ( )Tj EMC [(INF and AD)30(A is com)16(parable in CD, but in UC, the)]TJ /Span<>> BDC ( )Tj EMC [(sur)-42(viv)16(al of)]TJ /Span<>> BDC ( )Tj EMC (INF is higher than )Tj 0.054 Tw T* (that of)Tj /Span<>> BDC ( )Tj EMC [(AD)30(A and GOL. Data on the)]TJ /Span<>> BDC ( )Tj EMC [(ef)-40(f)-43(icacy and sur)-42(viv)16(al of)]TJ /Span<>> BDC ( )Tj EMC (VEDO in the)Tj /Span<>> BDC ( )Tj EMC (1st and 2nd lines of)Tj /Span<>> BDC ( )Tj EMC [(therap)12.1(y are contradic)]TJ 0 Tw (-)Tj 0.026 Tw T* [(tor)-43(y)32(. Most studies assessing the)]TJ /Span<>> BDC ( )Tj EMC [(sur)-42(viv)16(al and ef)-40(f)-43(icacy of)]TJ /Span<>> BDC ( )Tj EMC [(biologic ag)12(ents do no)13(t e)-15(xceed one year)61.1(, that is insuf)-40(f)-43(icient )]TJ 0.042 Tw T* (to)Tj /Span<>> BDC ( )Tj EMC [(p)45.9(redict the)]TJ /Span<>> BDC ( )Tj EMC [(long-ter)-13.9(m outcome. There is d)26(ata on high long-ter)-13.9(m ef)-40(f)-43(icacy and sur)-42(viv)16(al of)]TJ /Span<>> BDC ( )Tj EMC [(UST without signif)-43(icant )]TJ 0 Tw 0 -1.111 TD (loss of)Tj /Span<>> BDC ( )Tj EMC (response for 4\2265)Tj /Span<>> BDC ( )Tj EMC [(years in bio naiv)13(e IBD patients and in bio failures. UST has a)]TJ /Span<>> BDC ( )Tj EMC [(higher sur)-42(viv)16(al rate than VEDO )]TJ -0.005 Tw 0 -1.111 TD [(in )0.5(the)]TJ /Span<>> BDC ( )Tj EMC 2.492 0 Td [(second )0.5(line )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.609 0 Td [(therap)12(y )0.5(in )0.5(case )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 7.118 0 Td [(loss )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 2.727 0 Td [(response )0.5(to)]TJ /Span<>> BDC ( )Tj EMC 4.669 0 Td [(INF)94(. )0.5(In )0.5(case )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.804 0 Td [(loss )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 2.727 0 Td [(response )0.5(to)]TJ /Span<>> BDC ( )Tj EMC [(biologics, )0.5(it )0.5(is )0.5(advisable )]TJ 0.023 Tw -31.146 -1.111 Td (to)Tj /Span<>> BDC ( )Tj EMC [(ev)16(aluate the)]TJ /Span<>> BDC ( )Tj EMC [(lev)13(el of)]TJ /Span<>> BDC ( )Tj EMC (antibodies and drug concentration in the)Tj /Span<>> BDC ( )Tj EMC (blood.)Tj 0.035 Tw T* [(C)21(ON)22(CLUSION: studies on the)]TJ /Span<>> BDC ( )Tj EMC [(sur)-41.9(viv)16(al and long-ter)-14(m ef)-40(f)-43(icacy of)]TJ /Span<>> BDC ( )Tj EMC [(biologic )0.5(therap)12(y are v)13(er)-43(y limited and contradictor)-42.9(y)32(. )]TJ -0.027 Tw T* [(More direct com)16(parativ)13.1(e studies of)]TJ /Span<>> BDC ( )Tj EMC [(dif)-40(ferent classes of)]TJ /Span<>> BDC ( )Tj EMC (biologics in the)Tj /Span<>> BDC ( )Tj EMC [(f)-43(irst and subseq)14(uent lines of)]TJ /Span<>> BDC ( )Tj EMC [(therap)12(y are need)]TJ 0 Tw (-)Tj 0.02 Tw T* [(ed. In real p)46(ractice, it is necessar)-42.9(y to)]TJ /Span<>> BDC ( )Tj EMC (consider the)Tj /Span<>> BDC ( )Tj EMC [(e)-14.9(xisting d)26(ata on the)]TJ /Span<>> BDC ( )Tj EMC [(sur)-41.9(viv)16(al of)]TJ /Span<>> BDC ( )Tj EMC [(biologics when choosing therap)12(y)32(.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 525.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( inf)-22(lammator)-42.9(y bow)12(el disease, IBD, Crohn)24(\245)37(s disease $CD$, ulcerativ)13(e colitis $UC$, biologics, immunog)12(enicity)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare that there is no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.037 Tc 0.035 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.044 Tw 6.479 0 Td [( B)-19.1(e)-18(l)-20.9(o)-13.3(u)-21.9(s)-19.1(o)-10.3(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)-23.9(A)-23(.)-23.5(, L)-27.6(e)-15.8(v)-51.8(i)-15.8(t)-48.9(s)-11.1(k)-24.2(a)-14.9(y)-24.2(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)40.6(V)39.7(.)-23.5(, L)-24.8(o)-9.2(m)-8.3(a)-11.2(k)-41.1(i)-3.2(n)-7.8(a E)-5.6(.)51.6(Y)12.6(u)-9(.)-23.5(, T)40.4(e)-14.4(b)-24.6(e)-12.1(r)-18.1(d)-15.8(i)-11(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)40.6(V)39.7(. C)-16.4(o)-9.2(m)-5.2(p)-20(a)-10.2(r)-30.8(a)-18.2(t)-46.1(i)-14.5(v)-18.7(e e)-18.5(f)-62.6(f)-62.9(i)-5(c)-21.5(a)-11.1(c)-42.4(y a)-7.6(n)-14.5(d s)-8.8(u)-7.6(r)-58.3(v)-51.8(i)-14.5(v)-28.3(a)-11.5(l o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(b)-19.5(i)-6.8(o)-15.6(l)-20.9(o)-18.6(g)-28.9(i)-5(c)-32.2(s i)-3.2(n)23( )]TJ -0.005 Tw -6.484 -1.2 Td [(i)-3.2(n)-13.5(f)-47.1(l)-37.8(a)-9.6(m)-6.2(m)-8.3(a)-18.2(t)-21.9(o)-11.8(r)-60.6(y b)-20.4(o)-8.4(w)-17.7(e)-18(l d)-15.8(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.8(e i)-3.2(n d)-15.8(i)-12.1(f)-62.5(f)-28.4(e)-12.1(r)-19.1(e)-11.5(n)-17.3(t l)-16.7(i)-3.2(n)-16.1(e)-22.8(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e)-12.1(r)-30.8(a)-8.7(p)-19.7(y)-21.4(: t)-26.1(h)-15.1(e)]TJ /Span<>> BDC ( )Tj EMC [(c)-14.5(l)-16.6(i)-3.2(n)-14(i)-5(c)-38.2(i)-5.1(a)-7.6(n)-12.8(\241)20.6(s v)-51.8(i)-11(e)-12.5(w o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e p)-13.7(r)-15.8(o)-11.6(b)-18.2(l)-23.7(e)-11.5(m)-6.1(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_2 1 Tf 0 Tc 0.018 Tw 47.559 0 Td [( 2)-31.9(0)-26.8(2)-24.4(5;)-13.2(2)-14.2(4)-36.5($)14.7(1)21.3($)-8.5(:)-2.1(1)-9(0)-18.4(3)-35.1(\226)27.8(1)6.8(1)-10.5(4)-24(. )]TJ 0.023 Tc 0.024 Tw -47.559 -1.2 Td [($)-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2($)10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)-1.5(5)-23.5(-)9.8(2)8.7(4)-28.5(-)55.1(1)26.9(-)55.2(1)14(0)4.5(3)-13.3(-)55.2(1)29.7(1)12.5(4)]TJ /T1_1 1 Tf 0.01 Tc 0.098 Tw 0.005 -2.617 Td [(\021\024\027\030\026)5( \024\033\023)5( \215\030\027\030\215\032\026\037\032:)]TJ /T1_0 1 Tf 0 Tc 0.103 Tw 10.737 0 Td ( \216\016\036\022\035\024\021\037\030 \213\020\037\024\035\037\024\022\030\ \215\027\037\005\022\b\022\033\034\036\020\037, \231\230\207\202 \240\211\ \253\240\034\024\021\034\036\024\021\022\t \034\025\027\037\024\035\020\ \034\t \020\037\023\n\020\034-\022\024\024\027\016\005\034\036\037\035\016\ \027\007\024\021\022\t \021\027\022\020\022\n\016)Tj 0 Tw (-)Tj 0.023 Tw -10.742 -1.2 Td (\024\021\022\t \022\020\024\035\022\035\023\035 \022\b. \240.\233.)Tj /Span<>> BDC ( )Tj EMC (\215\027\037\005\022\b\022\033\024\021\034\013\034\273, \023\027.)Tj /Span<>> BDC ( )Tj EMC (\246\016\f\021\022\020\037, \005.)Tj /Span<>> BDC ( )Tj EMC (61/2, \240\034\024\021\036\037, 129110, \255\034\024\024\022\030; e-mail\ : 11anastasiya.levi@gmail.com)Tj /T1_1 1 Tf 0.01 Tc 0.095 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.1 Tw 14.205 0 Td [( Anastasia V)61(. Levitsk)11.1(aya, Moscow R)21(egional R)21(esearch and Clinical Institute $MONIKI$, Shchepkina st., 61/2, )]TJ 0.023 Tw -14.21 -1.2 Td [(Moscow)52(, 129110, R)22(ussia; e-mail: 11anastasiya.levi@gmail.com)]TJ 0 Tw 0 -2.792 TD (\203\037\035\037 \f\034\024\035\023\f\027\016\020\022\030)Tj /Span<>> BDC ( )Tj EMC (\227 05.06.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\201\034\024\027\016 \005\034\033\037\025\034\035\021\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.12.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\201\033\022\020\030\035\034 \021)Tj /Span<>> BDC ( )Tj EMC (\f\023\025\027\022\021\037\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 05.06.2024)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2024)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 06.02.2024)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 347.3119 Tm (\023\023\034\226\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.015 Tw 10 0 0 10 70.8661 322.9559 Tm (\200\024\f\023\026\035\017\021\036\035\034\027\t\036 \026\002\024\035\036\ \r\026\027\017\016 \022\017\001\036\004\027\017\022\026 $\200\003\025$\ , \022)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.304 Tw 0 -1.218 TD (\021\024\030\t\n \024\021\027\024\f\016\021\f\016 \002\024\035\036\027\034\ \025\030\024\027\026 $\207\025$ \017)Tj /Span<>> BDC ( )Tj EMC (\016\r\036\027\027\t\005 )Tj 0.397 Tw T* [(\022\024\035\017\021 $\254\025$, \016\r\035\016\033\021\f\016 )0.5(\021\016\032\036\035\t\n\017 \017\n\n\031\027\024-\r\024\f\023\026\035\017\ )]TJ 0 Tw (-)Tj 0.145 Tw T* [(\021\036\035\034\027\t\n\017 \026\002\024\035\036\r\026\027\017\016\n\017\ )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\031\033\021\f\016 \016\r\036\027)Tj 0 Tw (-)Tj 0.072 Tw T* (\027\024-\007\036\f\021\030\031\022\021\017\r\027\t\n\017 \017\n\036\027\ \036\027\017\016\n\017 \032\036\035\031\007\024\004\027\024-\022\017\001\ \036\004)Tj 0 Tw (-)Tj 0.276 Tw T* [(\027\024\020\024 \021\030\026\022\021\026 $\240\025\224$, \b\030\024\027\ \017\004\036\f\022\017\n )0.5(\030\036\006\017\007\017\r\017\030\031\033\013\017\n )]TJ 0.221 Tw T* [(\017\035\017 \027\036\023\030\036\030\t\r\027\t\n \021\036\004\036\027\017\ \036\n, )0.5(\030\026\r\017\021\017\036\n \f\017\f\021\036\n\027\024\020\024 )]TJ 0.326 Tw T* (\r\024\f\023\026\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\036\n )0.5(\r\027\036\022\017\001\036\004\027\t\b \023\030\024\016\r\035\036\027\017\ \005 )]TJ 0.213 Tw T* ([1]. \003\026\002\024\035\036\r\026\036\n\024\f\021\034 \200\003\025 \023\ \024\f\021\024\016\027\027\024 \030\026\f\021\036\021 \r\024 \r\f\036\b \ )Tj 0.368 Tw T* (\f\021\030\026\027\026\b, \024\f\024\002\036\027\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\f\021\030\017\026\035\034\027\024 \030\026\r\017\021\t\ \b. )Tj 0.067 Tw T* (\254\r\036\027\027\t\005 \022\024\035\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\034 \025\030\024\027\026 \026\027\017\n\026\033\021\ \r\036\007\031\013\036\036 )Tj 0.071 Tw T* (\n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 \017\027\r\026\035\017\007\027\024\f\021\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\030\021\027\024\f\021\017 \f\030\036\007\017 )Tj 0.066 Tw T* (\026\002\024\035\036\r\026\027\017\005 \240\025\224 [2]. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\031\035\016\006\017\017 \002\024\035\034\027\t\b \200\003\025\ \024\f)Tj 0 Tw (-)Tj 0.002 Tw T* (\027\024\r\027\031\033 \007\024\035\033 $\024\022\024\035\024 80%$ \f\024\ \f\021\026\r\035\016\033\021 \035\017\006\026, \026\002\024\035\036\r)Tj 0 Tw (-)Tj 0.136 Tw T* (\001\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 20\22640)Tj /Span<>> BDC ( )Tj EMC (\035\036\021, \004\021\024 \024\023\030\036\007\036\035\016\036\021 \r\t\ \f\024\022\031\033 )Tj 0.07 Tw T* (\f\024\006\017\026\035\034\027\031\033 \027\026\004\017\n\024\f\021\034\ \220\021\017\b \026\002\024\035\036\r\026\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024)Tj 0 Tw (-)Tj 0.059 Tw T* (\007\017\n\024\f\021\034 \027\026\027\026\004\036\027\017\016 \030\026\027\ \027\036\005 \026\007\036\022\r\026\021\027\024\005 \021\036\030\026\023\ \017\017 \007\035\016 )Tj 0.055 Tw T* [(\f\024\006\017\026\035\034\027\024\005 )0.5(\026\007\026\023\021\026\006\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.559 0 Td [(\023\024\r\t\001\036\027\017\016 )0.5(\022\026\004\036\f\021\r\026 )0.6(\032\017\027\017 )]TJ 0.235 Tw -10.559 -1.218 Td (\023\026\006\017\036\027\021\024\r [2]. \214\036\004\036\027\017\036 \200\ \003\025 \021\030\036\002\031\036\021 \027\026\004\017\021\036\035\034\027\ \t\b )Tj 0.151 Tw T* (\026\021\030\026\021 \017)Tj /Span<>> BDC ( )Tj EMC (\024\022\026\t\r\026\036\021 \f\036\030\034\036\027\024\036 \r\035\017\ \016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\033\007\032\036\021\t )Tj 0.264 Tw T* (\007\030\026\r\024\024\b\030\026\027\036\027\017\016 \030\026\027\t\b \ \f\021\030\026\027 [2]. \203\036\023\030\026\r\017\035\034\027\026\016, \ )Tj 0.028 Tw 23.244 26.792 Td (\027\036\024\023\021\017\n\026\035\034\027\026\016 \017\035\017 \023\024\ \007\027\024 \027\026\027\026\004\036\027\027\026\016 \021\036\030\026\ \023\017\016, \027\036)Tj 0 Tw (-)Tj 0.194 Tw T* (\f\024\002\035\033\007\036\027\017\036 \021\036\030\026\023\036\r\021\017\ \004\036\f\022\017\b \030\036\032\017\n\024\r, \027\036\007\024\f\021\026\ \021\024\004)Tj 0 Tw (-)Tj 0.109 Tw T* (\027\026\016 \023\030\017\r\036\030\032\036\027\027\024\f\021\034 \023\026\ \006\017\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \031\r\036\035\017\004\017)Tj 0 Tw (-)Tj -0.017 Tw T* (\r\026\033\021 \002\030\036\n\016 \026\002\024\035\036\r\026\027\017\016\ \022\026\022 \007\035\016 \023\026\006\017\036\027\021\024\r, \021\026\022\ \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\016 )Tj 0.35 Tw T* (\027\026\006\017\024\027\026\035\034\027\t\b \f\017\f\021\036\n \007\030\ \026\r\024\024\b\030\026\027\036\027\017\016. \211\f\023\036\001\027\024\ \036 )Tj 0.056 Tw T* (\035\036\004\036\027\017\036 \007\024\035\032\027\024 \023\030\017\r\024\ \007\017\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\005 )Tj 0.049 Tw T* [(\030\036\n\017\f\f\017\017, )0.5(\f\027\017\032\036\027\017\033 )0.6(\004\026\f\021\024\021\t )0.5(\024\023\036\030\026\006\017\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 17.596 0 Td (\020\024\f\023\017\021\026\035\017)Tj 0 Tw (-)Tj 0.05 Tw -17.596 -1.218 Td (\026\006\017\005, \004\021\024 \007\024\035\032\027\024 \f\023\024\f\024\ \002\f\021\r\024\r\026\021\034 \f\027\017\032\036\027\017\033 \002\030\036\ \n\036)Tj 0 Tw (-)Tj T* (\027\017 \002\024\035\036\027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\021\030\026\021 \007\030\026\r\024\024\b\030\026\027\036\027\017\016\ [3].)Tj 0.014 Tw T* [(\215\024\016\r\035\036\027\017\036 )0.5(\020\036\027\027\024-\017\027\032\036\027\036\030\027\t\b )0.6(\002\017\024\035\024\020\017\004\036\f\022\017\b )0.6(\023\030\036\023\026)]TJ 0 Tw (-)Tj 0.106 Tw T* (\030\026\021\024\r $\206\230\207\215$ \f\024\r\036\030\001\017\035\024\ \030\036\r\024\035\033\006\017\033 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \200\003\025 )Tj 0.243 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\034\027\036\005\001\036\005 \023\036\030\f\023\036\022\021\017\ \r\024\005 \n\024\007\017\235\017\022\026\006\017\017 )0.5(\021\036\004\036\027\017\016 )]TJ 0.068 Tw T* [(\026\002\024\035\036\r\026\027\017\005. )0.6(\210\007\027\026\022\024 )0.5(\007\026\027\027\t\036 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 13.87 0 Td [(\023\030\017\024\030\017\021\036\021\027\024\f\021\017 )0.6(\027\026)]TJ 0 Tw (-)Tj -0.036 Tw -13.87 -1.218 Td (\027\026\004\036\027\017\016 \021\036\b \017\035\017 \017\027\t\b \206\230\ \207\215 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\b )Tj 0.296 Tw T* (\035\017\027\017\016\b \021\036\030\026\023\017\017 \024\020\030\026\027\ \017\004\036\027\t. \210\023\030\036\007\036\035\036\027\027\024\020\024\ \026\035\020\024)Tj 0 Tw (-)Tj -0.013 Tw T* (\030\017\021\n\026 \023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\ \f\021\017 \023\030\017\n\036\027\036\027\017\016 \206\230\207\215 \023\024\ \022\026 \027\036 )Tj 0.032 Tw T* [(\f\031\013\036\f\021\r\031\036\021. \230\031\004\036\027\017\036 )0.5(\253\r\t\032\017\r\026\036\n\024\f\021\017\273 \030\026\027\t\b \206\230\ \207\215 )]TJ -0.003 Tw T* (\n\024\032\036\021 \023\030\017\002\035\017\017\021\034 \027\026\f \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\027\017\n\026\027\017\033 \024\023\021\017\n\026\035\034\027\024\ \005 \023\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017 \027\026\027\ \026\004\036\027\017\016 \030\026\027\t\b \022\035\026\f\f\024\r \206\230\ \207\215 )Tj 0.415 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\017\n\n\031\027\024-\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.5(\026\002\024\035\036\r\026\027\017\016\b, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\024\n )Tj 0 Tw T* (\004\017\f\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\003\025.)Tj 0.018 Tw T* [(\224\036\030\n\017\027 \253\r\t\032\017\r\026\036\n\024\f\021\034\273 \021\ \036\030\026\023\017\017 \206\230\207\215 $\026\027\020\035. sur)-32(v)-16(i)-15.9(v)]TJ 0 Tw 21.758 0 Td (-)Tj -0.014 Tw -21.758 -1.218 Td [(al \017\035\017 per)-10(sistence$)]TJ /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \023\036\030\017\024\007 \r\030\036\n\036\027\017 \024\ \021 \n\024\n\036\027\021\026 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 0 Tw 9 0 0 9 73.5728 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.8528 56.0378 Tm (104)Tj ET endstream endobj 541 0 obj [547 0 R] endobj 542 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 289.5098 42.7216 Tm [(Compar)21(ativ)12.1(e ef)-31(f)-21(icacy and sur)-21(viv)10(al of\022biologics in inflammator)-31(y bow)11(el )]TJ -0.033 -1 Td [(disease in dif)-30.9(fer)31(ent lines of\022th)11(er)21.1(apy: th)11(e\022clinician\226)63(s vie)11(w of\022th)11(e pr)20(oblem)]TJ -32.899 1 Td [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-10(\026\n \b\022\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-\b\t\235\f\t\f\017\t\240\002 )]TJ 0 -1 TD [(\210\b\025\013\025\020\b\213\f\205\007\b\002 \223\017\f\223\005\017\005\026\ )11(\025\016 $\031\030\214\034$ \223\017\b\022\016\025\205\223\005\013\b\026\ )11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 )]TJ T* [(\007\b\203\f\213\t\b\007\005 \016\022\017\005\001\t\240\002 \013\b\t\b\002\ \026)11(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-10(\013\b\t\b\216\b\205)-9.9(\026)11(\005 \t\005\022\223\017\025\210\013\f\024\220)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 240.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 240.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 203.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 203.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2025-24-1-103-114)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 54.5932 695.3259 Tm [(\207\017\005\016\t\b\026)11(\f\013\n\t\005 \241\211\211\f\007)-10(\026\b\016\t\025\205)-9.9(\026\n \b\022)-23.3(\016\240\235\b\016\005\f\024\025\205)-10(\026\n \020)10(\f\t\t\025-)]TJ 1.285 -1.105 Td [(\b\t\235\f\t\f\017\t\240\002 \210\b\025\013\025\020\b\213\f\205\007\b\002\ \223\017\f\223\005\017\005\026)11(\025\016 $\031\030\214\034$ )]TJ -1.693 -1.105 Td [(\223\017\b\022)-23.3(\016\025\205\223\005\013\b\026)11(\f\013\n\t\240\002 \001\005\210\025\013\f\016\005\t\b\002 \007\b\203\f\213\ \t\b\007\005 \016\022)-23.3(\017\005\001\t\240\002 )]TJ 1.589 -1.105 Td [(\013\b\t\b\002 \026)11.1(\f\017\005\223\b\b: \016)32(\001\020)21(\013\217 \007)-9.9(\013\b\t\b\216\b\205)-10(\026)11(\005 \t\005\022)-23.2(\223\017\025\210\013\f\024\220)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 607.822 Tm [(\035\f\016\b\026)21(\205\007\005\022)-23.2(\006)-31(.\r., \214\f\013\025\220\205\025\016\005\022)-23.2(\021.\006)-31(., \035\025\024\005\007\b\t\005\022)-23.2(\021.\003., \032)40(\f\210\f\017\217\b\f\016\005\022)-23.2(\204.\r.)]TJ 10 0 0 10 42.5197 590.1527 Tm [(\031\214)42(\230)31(\231 \204\036 \253\204\025\205\007)10(\025\016\205\007\b\255 \025\210\013\005\205)-9.9(\026\t\025\255 \t\005\220\213\t\025-\b\205\205)-9.9(\013\f\217\025\016\005\026)11(\f\013\n\205\007\b\255 \007)-10(\013\b\t\b\213\f\205\007\b\255 \b\t\205)-10(\026\b\026)-20(\220)-19.9(\026 )]TJ 0 -1.2 TD [(\b\024.\022)-23.3(\204.\201.\022)-23.3(\r\013\005\217\b\024\b\017\205\007)10(\025\020)10(\025\273 $\220\013.\022)-23.3(\212\f\223\007\b\t\005, \217.\022)-23.3(6)113(1/2, \020)62(.\022)-23.2(\204\025\205\007\016\005, 1)125(2)47(9)125.1(1)211.9(1)75.1(0, \033\025\205\205\b$)]TJ /T1_1 1 Tf 0.342 Tw 9 0 0 9 90.7087 559.6488 Tm (\211\230\211\002\222\211\215\213\222\235\205: \036\032\003\022\036\037\016\ \b\034\024\035\007 \013\016\020\020\034-\022\020\003\016\020\016\033\020\ \032\001 \025\022\034\027\034\013\022\n\016\024\021\022\001 \f\033\016\f\ \037\033\037\035\034\036 $\231\235\230\201$ \034\031\020\037\n\037\016\ \035 \f\016\033\022\034\005 )Tj 0.091 Tw 0 -1.111 TD [(\036\033\016\b\016\020\022 )0.5(\034\035 \b\034\b\016\020\035\037 \020\037\031\020\037\n\016\020\022\030\ )0.5(\231\235\230\201 )0.5(\005\034)]TJ /Span<>> BDC ( )Tj EMC [(\b\034\b\016\020\035\037 )0.5(\f\033\016\021\033\037\217\016\020\022\030 )0.5(\f\033\022\016\b\037 \f\033\016\f\037\033\037\035\037, \f\034\035\016\033\ \022 )0.5(\034\035\036\016\035\037 \022\027\022 )]TJ 0.06 Tw T* (\005\034)Tj /Span<>> BDC ( )Tj EMC (\b\034\b\016\020\035\037 \f\016\033\016\021\027\026\n\016\020\022\030 \020\ \037)Tj /Span<>> BDC ( )Tj EMC (\005\033\023\013\034\t \f\033\016\f\037\033\037\035. \204\035\034 \f\037\ \033\037\b\016\035\033, \034\035\033\037\003\037\026\217\022\t \005\034\027\ \013\034\024\033\034\n\020\023\026 \035\016\033\037\f\016\036\035\022\n\016\ )Tj 0 Tw (-)Tj 0.087 Tw T* (\024\021\023\026 \220\017\017\016\021\035\022\036\020\034\024\035\007, \025\ \016\031\034\f\037\024\020\034\024\035\007 \022)Tj /Span<>> BDC ( )Tj EMC (\f\033\022\036\016\033\003\016\020\020\034\024\035\007 \021)Tj /Span<>> BDC ( )Tj EMC (\231\235\230\201 \036)Tj /Span<>> BDC ( )Tj EMC (\033\016\037\027\007\020\034\t \021\027\022\020\022\n\016\024\021\034\t \ \f\033\037\021\035\022\021\016. \211\006\016\020\021\037 )Tj -0.027 Tw T* [(\036\032\003\022\036\037\016\b\034\024\035\022 )0.5(\231\235\230\201 \022)]TJ /Span<>> BDC ( )Tj EMC [(\037\020\037\027\022\031 \f\033\022\n\022\020 \016\016 \024\020\022\003\016\ \020\022\030 \030\036\027\030\026\035\024\030 )0.5(\023\005\034\025\020\032\b \022\020\024\035\033\023\b\016\020\035\034\b \ \022)]TJ /Span<>> BDC ( )Tj EMC (\031\020\037\n\022\b\032\b \017\037\021\035\034\033\034\b )Tj 0.023 Tw 0 -1.111 TD (\f\034\036\032\004\016\020\022\030 \220\017\017\016\021\035\022\036\020\034\ \024\035\022 \027\016\n\016\020\022\030 \215\202\r.)Tj -0.02 Tc 0.226 Tw 8.64 0 0 9 90.7087 499.6488 Tm (\212\205\216\221: \f\033\034\036\016\024\035\022 \037\020\037\027\022\031\ \f\023\025\027\022\021\037\006\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\034\006\016\020\022\035\007 \035\016\021\023\217\016\016 \024\034\024\035\ \034\030\020\022\016 \036\034\f\033\034\024\037 \f\034)Tj /Span<>> BDC ( )Tj EMC [(\024\033\037\036\020\022\035\016\027\007\020\034\t \220\017\017\016\021\035\ \022\036\020\034\024\035\022)-20( )]TJ -0.009 Tw 0 -1.111 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\036\032\003\022\036\037\016\b\034\024\035\022 \231\235\230\201 \033\037\ \031\020\032\001 \021\027\037\024\024\034\036 \036)Tj /Span<>> BDC ( )Tj EMC (\033\037\031\020\032\001 \027\022\020\022\030\001 \035\016\033\037\f\022\ \022 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\036\034\024\f\037\027\022\035\016\027\007\020\032\001 \031\037\025\034\027\ \016\036\037\020\022\030\001 \021\022\004\016\n\020\022\021\037 $\215\202\ \r$.)Tj 0 Tc 0.041 Tw 9 0 0 9 90.7087 479.6488 Tm [(\240\213\200\205\255\235\213\216\223 )0.6(\235)]TJ /Span<>> BDC ( )Tj EMC 6.248 0 Td [(\240\205\200\211\203\223: )0.6(\f\034\022\024\021 )0.6(\f\023\025\027\022\021\037\006\022\t )0.6(\f\033\034\036\034\005\022\027\024\030 )0.6(\036)]TJ /Span<>> BDC ( )Tj EMC 17.46 0 Td [(\025\037\031\037\001 )0.6(\005\037\020\020\032\001 )0.6(PUBMED, )0.6(MEDLINE, )0.6(EMBASE )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 17.786 0 Td (Cochrane )Tj -0.016 Tw -41.493 -1.111 Td [(Library )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 3.524 0 Td [(2013 )0.6(\f\034 )0.5(2024)]TJ /Span<>> BDC ( )Tj EMC 5.63 0 Td [(\013\013. )0.6(\f\034)]TJ /Span<>> BDC ( )Tj EMC 2.498 0 Td [(\021\027\026\n\016\036\032\b )0.6(\024\027\034\036\037\b\022 )0.7(\022)]TJ /Span<>> BDC ( )Tj EMC 8.682 0 Td [(\017\033\037\031\037\b )0.6(\242Inflammatory )0.6(bowel )0.6(disease, )0.6(ulcerative )0.5(colitis, )0.5(Crohn\245s )]TJ 0.033 Tw -20.334 -1.111 Td (disease, biologics survival/persistence, comparative efficacy of)Tj /Span<>> BDC ( )Tj EMC (biologics, biologics immunogenicity\243. \215)Tj /Span<>> BDC ( )Tj EMC (\033\034\024\024\022\t\024\021\034\t )Tj 0.023 Tw T* (\025\037\031\016 \005\037\020\020\032\001 \255\235\222\212 \f\034\005\034\ \025\020\032\001 \f\023\025\027\022\021\037\006\022\t \f\034)Tj /Span<>> BDC ( )Tj EMC (\035\016\b \003\016 \021\027\026\n\016\036\032\b \024\027\034\036\037\b \ \020\037\t\005\016\020\034 \020\016 \025\032\027\034.)Tj 0.039 Tw T* (\255\205\202\207\216\221\200\213\200\223: \f\034\035\016\033\030 \034\035\ \036\016\035\037 \024\034 \036\033\016\b\016\020\016\b \020\037\025\027\026\ \005\037\016\035\024\030 \005\027\030 \036\024\016\001 \231\235\230\201.\ \215\032\025\034\033 \f\016\033\036\034\013\034 \231\235\230\201 \b\034\ \003\016\035 \f\034\036\027\022)Tj 0 Tw (-)Tj 0.126 Tw 0 -1.111 TD (\030\035\007 \020\037)Tj /Span<>> BDC ( )Tj EMC (\220\017\017\016\021\035\022\036\020\034\024\035\007 \f\034\024\027\016\005\ \023\026\217\022\001 \027\022\020\022\t \035\016\033\037\f\022\022. \215\ )Tj /Span<>> BDC ( )Tj EMC (\f\016\033\036\034\t \027\022\020\022\022 \035\016\033\037\f\022\022 \n\037\ \217\016 \036\024\016\013\034 \020\037\031\020\037\n\037\026\035\024\030\ )Tj 0.017 Tw 0 -1.111 TD [(\022-\233\222\211, )0.6(\020\034 )0.6(\022\001 )0.5(\036\032\003\022\036\037\016\b\034\024\035\007 )0.6(\f\033\022)]TJ /Span<>> BDC ( )Tj EMC 13.579 0 Td [(\215\202\r )0.6(\025\034\027\016\016 )0.6(\020\022\031\021\037\030 )0.6(\f\034)]TJ /Span<>> BDC ( )Tj EMC 8.689 0 Td [(\024\033\037\036\020\016\020\022\026 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 5.311 0 Td [(\231\235\230\201 )0.6(\005\033\023\013\022\001 )0.6(\021\027\037\024\024\034\036: )0.5(\023)]TJ /Span<>> BDC ( )Tj EMC 9.734 0 Td [(\f\034\027\034\036\022\020\032 )0.5(\025\034\027\007\020\032\001 )]TJ 0.095 Tw -37.312 -1.111 Td (\220\017\017\016\021\035\022\036\020\034\024\035\007 \024\034\001\033\037\ \020\030\016\035\024\030 \020\016 \025\034\027\016\016 1\2262)Tj /Span<>> BDC ( )Tj EMC (\027\016\035. \201\016\033\016\021\027\026\n\016\020\022\016 \036)Tj /Span<>> BDC ( )Tj EMC (\033\037\b\021\037\001 \034\005\020\034\013\034 \021\027\037\024\024\037\ \231\235\230\201 $\022-\233\222\211$ \024\020\022)Tj 0 Tw (-)Tj 0.073 Tw T* (\003\037\016\035 \220\017\017\016\021\035\022\036\020\034\024\035\007 \036\ \035\034\033\034\t \027\022\020\022\022 \035\016\033\037\f\022\022. \215\ \032\003\022\036\037\016\b\034\024\035\007 \235\222\233 \022)Tj /Span<>> BDC ( )Tj EMC (\213\203\213 \024\034\f\034\024\035\037\036\022\b\037 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\230\r, \020\034 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\250\r )Tj -0.024 Tw T* [(\036\032\003\022\036\037\016\b\034\024\035\007 )0.7(\235\222\233 )0.6(\036\032\004\016, )0.5(\n\016\b )0.6(\023)]TJ /Span<>> BDC ( )Tj EMC 13.463 0 Td [(\213\203\213 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 2.582 0 Td [(\231\211\216. )0.6(\203\037\020\020\032\016 )0.6(\034\025 )0.6(\220\017\017\016\021\035\022\036\020\034\024\035\022 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 14.464 0 Td [(\036\032\003\022\036\037\016\b\034\024\035\022 )0.6(\215\205\203\211 )0.6(\036)]TJ /Span<>> BDC ( )Tj EMC 9.549 0 Td [(1 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 1.416 0 Td [(2 )0.6(\027\022\020\022\030\001 )]TJ 0.019 Tw -41.474 -1.111 Td (\035\016\033\037\f\022\022 \f\033\034\035\022\036\034\033\016\n\022\036\032\ . \230\034\027\007\004\022\020\024\035\036\034 \022\024\024\027\016\005\034\ \036\037\020\022\t \f\034)Tj /Span<>> BDC ( )Tj EMC (\034\006\016\020\021\016 \036\032\003\022\036\037\016\b\034\024\035\022 \ \022)Tj /Span<>> BDC ( )Tj EMC (\220\017\017\016\021\035\022\036\020\034\024\035\022 \231\235\230\201 \020\ \016 )Tj -0.014 Tw T* (\f\033\016\036\032\004\037\026\035 \034\005\020\034\013\034 \013\034\005\ \037, \n\035\034 \020\016\005\034\024\035\037\035\034\n\020\034 \005\027\ \030 \f\033\034\013\020\034\031\022\033\034\036\037\020\022\030 \005\034\ \027\013\034\024\033\034\n\020\034\013\034 \033\016\031\023\027\007\035\037\ \035\037. \205\024\035\007 \005\037\020\020\032\016 )Tj 0.08 Tw T* (\034)Tj /Span<>> BDC ( )Tj EMC (\036\032\024\034\021\034\t \005\034\027\013\034\024\033\034\n\020\034\t \ \220\017\017\016\021\035\022\036\020\034\024\035\022 \022)Tj /Span<>> BDC ( )Tj EMC (\036\032\003\022\036\037\016\b\034\024\035\022 \207\002\200 \025\016\031\ \031\020\037\n\022\b\034\t \f\034\035\016\033\022 \034\035\036\016\035\037\ \020\037)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\035\030\003\016)Tj 0 Tw (-)Tj 0.062 Tw T* [(\020\022\022 )0.5(4\2265)]TJ /Span<>> BDC ( )Tj EMC [(\027\016\035 )0.5(\023)]TJ /Span<>> BDC ( )Tj EMC 6.253 0 Td [(\025\022\034\020\037\022\036\020\032\001 )0.6(\f\037\006\022\016\020\035\034\036 )0.5(\215\202\r )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 12.8 0 Td [(\023 )0.5(\025\022\034\017\220\t\027\034\033\034\036. )0.5(\207\002\200 )0.5(\022\b\016\016\035 )0.5(\025\034\027\007\004\023\026 \036\032\003\022\036\037\016\b\034\024\035\007\ , \n\016\b \215\205\203\211 )]TJ 0.056 Tw -19.053 -1.111 Td (\036\034 \036\035\034\033\034\t \027\022\020\022\022 \035\016\033\037\f\022\ \022 \036)Tj /Span<>> BDC ( )Tj EMC (\024\027\023\n\037\016 \f\034\035\016\033\022 \034\035\036\016\035\037 \020\ \037)Tj /Span<>> BDC ( )Tj EMC (\022-\233\222\211. \201\033\022)Tj /Span<>> BDC ( )Tj EMC (\f\034\035\016\033\016 \034\035\036\016\035\037 \020\037)Tj /Span<>> BDC ( )Tj EMC (\231\235\230\201 \006\016\027\016\024\034\034\025\033\037\031\020\037 )Tj 0.023 Tw T* (\034\006\016\020\021\037 \036)Tj /Span<>> BDC ( )Tj EMC (\021\033\034\036\022 \023\033\034\036\020\016 \037\020\035\022\035\016\027\ \022)Tj /Span<>> BDC ( )Tj EMC (\021\034\020\006\016\020\035\033\037\006\022\022 \f\033\016\f\037\033\037\ \035\037.)Tj 0.194 Tw T* (\202\213\r\216\225\210\205\222\235\205: \022\024\024\027\016\005\034\036\ \037\020\022\030 \f\034)Tj /Span<>> BDC ( )Tj EMC (\036\032\003\022\036\037\016\b\034\024\035\022 \022)Tj /Span<>> BDC ( )Tj EMC (\005\034\027\013\034\024\033\034\n\020\034\t \220\017\017\016\021\035\022\ \036\020\034\024\035\022 \231\235\230\201 \034\n\016\020\007 \034\013\033\ \037\020\022\n\016\020\032 )Tj 0.141 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\033\034\035\022\036\034\033\016\n\022\036\032. \222\016\034\025\001\034\ \005\022\b\034 \025\034\027\007\004\016 \f\033\030\b\032\001 \024\033\037\ \036\020\022\035\016\027\007\020\032\001 \022\024\024\027\016\005\034\036\ \037\020\022\t \033\037\031\020\032\001 \021\027\037\024\024\034\036 \231\ \235\230\201 \036)Tj /Span<>> BDC ( )Tj EMC (\f\016\033)Tj 0 Tw (-)Tj 0.069 Tw T* (\036\034\t \022)Tj /Span<>> BDC ( )Tj EMC (\f\034\024\027\016\005\023\026\217\022\001 \027\022\020\022\030\001 \035\ \016\033\037\f\022\022. \215)Tj /Span<>> BDC ( )Tj EMC (\033\016\037\027\007\020\034\t \f\033\037\021\035\022\021\016 \020\016\034\ \025\001\034\005\022\b\034 \023\n\022\035\032\036\037\035\007 \024\023\217\ \016\024\035\036\023\026\217\022\016 \005\037\020\020\032\016 )Tj 0.023 Tw T* (\034)Tj /Span<>> BDC ( )Tj EMC (\036\032\003\022\036\037\016\b\034\024\035\022 \231\235\230\201 \f\033\022\ )Tj /Span<>> BDC ( )Tj EMC (\036\032\025\034\033\016 \035\016\033\037\f\022\022.)Tj /T1_2 1 Tf 0.01 Tc 0.07 Tw 8 0 0 8 42.5596 274.3795 Tm [(\037\033\255\200\030\025\202\030)5( \026\033\036\025\021:)]TJ /T1_1 1 Tf 0 Tc 0.075 Tw 8.545 0 Td ( \036\034\024\f\037\027\022\035\016\027\007\020\032\016 \031\037\025\034\ \027\016\036\037\020\022\030 \021\022\004\016\n\020\022\021\037, \025\034\ \027\016\031\020\007 \r\033\034\020\037, \030\031\036\016\020\020\032\t \ \021\034\027\022\035, \013\016\020\020\034-\022\020\003\016\020\016\033\020\ \032\016 \025\022\034\027\034\013\022\n\016\024\021\022\016 \f\033\016)Tj 0 Tw (-)Tj 0.023 Tw -8.55 -1.2 Td (\f\037\033\037\035\032, \036\032\003\022\036\037\016\b\034\024\035\007 \231\ \235\230\201, \022\b\b\023\020\034\013\016\020\020\034\024\035\007 \231\235\ \230\201)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\036\035\034\033\032\037\031)5( \032\035\031\030\027\030\026\036\025:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \037\036\035\034\033\032 \031\037\030\036\027\030\026\035 \034\025 \034\ \035\024\023\035\024\035\036\022\022 \021\034\020\017\027\022\021\035\037\ \022\020\035\016\033\016\024\034\036)Tj /T1_2 1 Tf 0.023 Tc -0.04 Tw -10.401 -2.617 Td [(\024\033\023)5.3( \022\032\031\032\027\036\025\021\035\032\023:)]TJ /T1_3 1 Tf 0.013 Tc -0.035 Tw 8.962 0 Td ( \214\036\r\017\021\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \207\036\035\024\031\f\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \214\024\n\026\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\213.\222., \224\036\002\036\030\007\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\200. \225\030\026\r\027\017\021\036\035\034\027\026\016 \220\235\235\ \036\022\021\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\032\017\r\026\036\n\024\f\021\034)13( )]TJ 0.023 Tc 0.106 Tw -8.967 -1.2 Td (\020\036\027\027\024-\017\027\032\036\027\036\030\027\t\b \002\017\024\035\ \024\020\017\004\036\f\022\017\b \023\030\036\023\026\030\026\021\024\r \ $\206\230\207\215$ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \026\002\024\035\036\r\ \026\027\017\016\b \022\017\001\036\004\027\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\t\b \035\017\027\017\016\b \021\036\030\026\023\017\017:)23.1( )]TJ 0.001 Tc -0.035 Tw 0 -1.2 TD [(\r)0.5(\020\035\016)0.5(\007 \022\035)0.5(\017\027\017)0.5(\006\017\f)0.5(\021\026 \027\026)]TJ /Span<>> BDC 8.884 0 Td ( )Tj EMC [(\023\030)0.5(\024\002\035\036)0.5(\n\031.)0.5( )]TJ /T1_1 1 Tf -0.001 Tw [(\r)0.5(\034\027\034)0.5(\f\033\034)0.5(\021\035\034)0.5(\027\034)0.5(\013\022\030)0.5(.)]TJ /T1_3 1 Tf -0.035 Tw [( 202)0.5(5; \021.)]TJ /Span<>> BDC 15.805 0 Td ( )Tj EMC [(24,)0.5( \223)]TJ /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC 4.241 0 Td ( )Tj EMC [(103)0.5(\226114)0.5(. htt)0.5(ps:)0.5(//d)0.5(oi.)0.5(org/)0.5(10.)0.5(3387)0.5(8/20)0.5(73-)0.5(755)0.5(6-20)0.5(25-2)0.5(4-1-)0.5(103)0.5(-11)0.5(4)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 102.502 177.0331 Tm [(Compar)21(ativ)12.1(e ef)-30.9(f)-21(icacy and sur)-21(viv)10(al of\022)-23.2(biologics )]TJ -0.095 -1.167 Td [(in inflammator)-31(y bow)11.1(el disease in dif)-31(fer)31(ent lines )]TJ 0.338 -1.167 Td [(of\022)-23.3(th)11(er)21(apy: th)11(e\022)-23.3(clinician\226)63.1(s vie)11(w of\022)-23.2(th)11(e pr)20(oblem)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 113.3639 Tm [(Anastasia\022)-23.2(V)62(.\022)-23.3(Le)11(vitskay)21.1(a, Elena\022)-23.3(A)-30.9(.\022)-23.3(Belousov)10(a, Ekaterina\022)-23.2(Y)40(u.\022)-23.2(Lomakina, )]TJ 0 Tw 0 -1.143 TD [(Mariana\022)-23.2(V)62(.\022)-23.3(T)40(eber)31(die)11(v)10(a)]TJ 0.023 Tw 10 0 0 10 42.5197 79.6946 Tm [(Moscow Regional Resear)31.1(ch and Clinical Institute $MONIKI$ $Shch)11.1(epkina\022)-23.3(st., 6)113(1/2, Moscow)22.1(, 1)125(2)47(9)125(1)212(1)75(0, Russia$)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 568.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 559.226 Tm (\027\030\203\255\204\030)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc 0.018 Tw 13 0 0 13 42.5845 832.0225 Tm [(\004\210)42(\215\004\n)5( \b\006\r\207\n)43(\037)31(\r)-21(\013\n\233)]TJ /T1_0 1 Tf -0.01 Tw 14 0 0 14 42.5895 809.5532 Tm (REVIEW)Tj ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\214)10(\231\036\033 \035\030\032\021\033)30(\006)42(\032)-21(\230\033\237)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4771 56.0378 Tm (103)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 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P)35(r)-32(ophyl)-15.9(a)-17(c)-16(t)-32(ic )]TJ 0.274 Tw -1.796 -1.25 Td [(Mesh Pl)-15.9(a)-17(cement Dur)-36.9(ing F)10(or)-16(ma)15(t)-32(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(an End-col)30.1(ost)17(omy R)13(educes )]TJ 0.267 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(R)-10(a)15(te of)]TJ /Span<>> BDC ( )Tj EMC [(P)40(ar)-33(ast)17(omal Her)-15(nia: S)-16(hor)-21.9(t-ter)-16(m R)13(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Dutch )]TJ 0 Tw T* [(PREVENT-tr)-36.9(ial. )]TJ /T1_0 1 Tf 0.023 Tw 6.163 0 Td (Annals of)Tj /Span<>> BDC ( )Tj EMC [(surg)12(er)-43(y.)]TJ /T1_1 1 Tf ( 2017;265$4$:663\226669.)Tj -0.056 Tw -6.163 -1.25 Td (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (L\363pez-Cano)Tj /Span<>> BDC ( )Tj EMC [(M, Ser)-24(r)-32.9(a-Ar)-33(a)-17(c)-23.9(il)]TJ /Span<>> BDC ( )Tj EMC [(X, M)-23.9(or)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(event)-32(ing P)40(ar)-32.9(ast)17(omal )]TJ 0.011 Tw -1.796 -1.25 Td [(Her)-15(nia Using a)]TJ /Span<>> BDC ( )Tj EMC [(M)-24(odif)-27.9(ied Sugar)-23.9(bak)10(er T)40(echnique W)-16(i)-24(t)-13(h Com)10(posi)-24(te Mesh )]TJ 0.266 Tw T* [(Dur)-37(ing L)-32(ap)32(ar)-32(oscopic A)-14(bd)-16(ominoper)-37(ineal R)13(esec)-16(t)-32(ion: A)]TJ /Span<>> BDC ( )Tj EMC [(R)-10(and)-16(omized )]TJ 0.023 Tw T* [(Contr)-32(olled T)50(r)-37(ial. )]TJ /T1_0 1 Tf (Annals of)Tj /Span<>> BDC ( )Tj EMC [(surg)12(er)-43(y.)]TJ /T1_1 1 Tf ( 2016;264$6$:923\226928.)Tj 0.164 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Odensten)Tj /Span<>> BDC ( )Tj EMC [(C, S)15(tr)-37(ig\345r)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(K, Ruteg\345r)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Use of)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ophyl)-15.9(a)-17(c)-16(t)-32(ic )]TJ 0.343 Tw -1.796 -1.25 Td [(Mesh When Cr)-24(ea)15(t)-32(ing a)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(ost)17(omy Does N)-13.9(o)17(t P)35(r)-23.9(event P)40.1(ar)-33(ast)17(omal )]TJ 0.006 Tc 0.349 Tw T* [(Her)-14.8(nia: A)]TJ /Span<>> BDC ( )Tj EMC [(R)-9.7(and)-15.7(omized Contr)-31.7(olled T)50.2(r)-36.7(ial)]TJ /Span<>> BDC ( )Tj EMC [(\227 S)-20.7(T)20.2(OMAMESH. )]TJ /T1_0 1 Tf -0.006 Tw [(Annals)6( )]TJ 0 Tc 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y.)]TJ /T1_1 1 Tf ( 2019;269$3$:427\226431.)Tj 0.005 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-22(udhomme)]TJ /Span<>> BDC ( )Tj EMC [(M, F)20(abbr)-32(o-P)30.1(er)-33(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(P, Rull)-31(ier)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Me)-12(t)15(a-anal)35(y)-13(sis and )]TJ 0.146 Tw -1.796 -1.25 Td [(Sy)-13(stema)15.1(t)-32(ic R)13(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he Use of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-32(ost)-12.9(he)-12(t)-32(ic Mesh for P)35(r)-24(event)-31.9(ion )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(P)40(ar)-33(ast)17.1(omal Her)-15(nia. )]TJ /T1_0 1 Tf (Annals of)Tj /Span<>> BDC ( )Tj EMC [(surg)12.1(er)-43(y.)]TJ /T1_1 1 Tf ( 2021;274$1$:20\22628.)Tj 0.282 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-24(ingbl)30(om)]TJ /Span<>> BDC ( )Tj EMC (C, Odensten)Tj /Span<>> BDC ( )Tj EMC [(C, S)15(tr)-36.9(ig\345r)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(o R)13(educ)-16(t)-31.9(ion in )]TJ 0.001 Tc 0.35 Tw -1.796 -1.25 Td [(P)40(ar)-33(ast)17(omal )0.6(Her)-15(nia )0.6(R)-10(a)15.1(te )0.6(3 )0.5(Y)30.1(ear)-9.9(s )0.6(af)-27.9(ter )0.6(S)15(t)17.1(oma )0.6(Constr)-21.9(uc)-15.9(t)-32(ion )0.6(wi)-24(t)-12.9(h)1( )]TJ 0 Tc -0.034 Tw T* [(P)35(r)-32(ophyl)-16(a)-17(c)-15.9(t)-32(ic Mesh: T)47(hr)-24(ee-year F)10(oll)30(o)-14(w-up R)13(esul)56(ts fr)-32(om S)-21(T)20(OMAMESH)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.341 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC 1.128 0 Td [(Mul)56(t)-32(icenter )0.5(Double-bl)-31(ind )0.5(R)-10(and)-16(omized )0.5(Contr)-31.9(olled )0.5(T)50(r)-37(ial. )]TJ /T1_0 1 Tf 0 Tw 23.866 0 Td (Annals )Tj 0.023 Tw -24.994 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y.)]TJ /T1_1 1 Tf ( 2023;277$1$:38\22642.)Tj 0.086 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Whi)-24(t)-30(t)15.1(ak)9.9(er)]TJ /Span<>> BDC ( )Tj EMC 4.246 0 Td [(M, Gol)-31(igher)]TJ /Span<>> BDC ( )Tj EMC (JC. A)Tj /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-33(a)]TJ 0 Tw (-)Tj 0.017 Tc 0.601 Tw -6.042 -1.25 Td [(p)0.5(er)-36.5(i)-23.5(t)17.5(o)0.5(n)0.5(ea)0.5(l)0.5( a)0.5(n)0.5(d i)0.5(nt)0.5(r)-32.5(a)0.5(p)0.5(er)-36.5(i)-23.5(t)17.5(o)0.5(n)0.5(ea)0.5(l)0.5( t)0.5(e)0.5(c)0.5(hn)0.5(i)0.5(q)0.5(u)0.5(es)0.5( f)0.5(o)0.5(r)0.5( c)0.5(o)0.5(ns)0.5(t)0.5(r)-21.5(u)0.5(c)-15.5(t)-31.5(io)0.5(n)17( )]TJ 0 Tc 0.289 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(ter)-16(minal il)-31(ia)-17(c col)30(ost)17.1(omies. )]TJ /T1_0 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the colon and rectum.)Tj /T1_1 1 Tf 0 Tw ( )Tj T* (1976;19$4$:342\226344.)Tj 0.221 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dong L-R, Zhu Y-M, Xu)Tj /Span<>> BDC ( )Tj EMC [(Q, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Cl)-31(inical ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(e)-17.9(xtr)-33(a)]TJ 0 Tw (-)Tj 0.273 Tw -1.796 -1.25 Td [(per)-37(i)-23.9(t)17(oneal col)30(ost)17(omy wi)-24(t)-13(hout d)42(ama)-17(ging t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(muscle l)-16(a)15(yer of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he )]TJ 0.009 Tc 0.349 Tw 29.055 55 Td [(abd)-15.8(ominal w)-11.7(all. )]TJ /T1_0 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Jour)-13.8(nal of)]TJ /Span<>> BDC ( )Tj EMC [(inter)-13.7(national medical research.)9( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (2012;40$4$:1410\2261416.)Tj 0.168 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hamad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(M, Ozak)-15.9(i)]TJ /Span<>> BDC ( )Tj EMC [(K, Mur)-33(aok)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)30(er)-16(manent end-sigmoid )]TJ 0.21 Tw -1.796 -1.25 Td [(col)30(ost)17(omy )0.5(t)-13(hr)-31.9(ough t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 10.002 0 Td [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal )0.5(r)-32(oute )0.5(p)25(r)-24(events )0.5(p)32(ar)-32.9(ast)17(omal )]TJ 0.008 Tc 0.349 Tw -10.002 -1.25 Td [(her)-14.6(nia af)-27.6(ter l)-15.6(ap)32.3(ar)-31.6(oscopic abd)-15.6(ominoper)-36.6(ineal r)-23.6(esec)-15.7(t)-31.6(ion. )]TJ /T1_0 1 Tf -0.008 Tw [(Diseases)8( )]TJ 0 Tc 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the colon and rectum.)Tj /T1_1 1 Tf ( 2012;55$9$:963\226969.)Tj 0.287 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(er)-32(oy)]TJ /Span<>> BDC ( )Tj EMC (J, Diana)Tj /Span<>> BDC ( )Tj EMC [(M, Call)-16(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ap)32(ar)-32(oscopic e)-18(xtr)-33(aper)-36.9(i)-24(t)17(o)]TJ 0 Tw (-)Tj 0.149 Tw -1.796 -1.25 Td [(neal col)30.1(ost)17(omy in elec)-15.9(t)-32(i)-16(ve abd)-16(ominoper)-36.9(ineal r)-24(esec)-16(t)-32(ion for cancer: )]TJ 0.086 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(single sur)-32(geon e)-17.9(xper)-37(ience. )]TJ /T1_0 1 Tf (Colorectal disease : the)Tj /Span<>> BDC ( )Tj EMC [(of)-39.9(f)-43(icial jour)-13.9(nal )]TJ 0.257 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the Association of)Tj /Span<>> BDC ( )Tj EMC [(Colop)46(roctology of)]TJ /Span<>> BDC ( )Tj EMC [(Great Br)-37(itain and Ireland.)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* (2012;14$9$:e618\22622.)Tj -0.007 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Heiying)Tj /Span<>> BDC ( )Tj EMC [(J, Y)40.1(onghong)]TJ /Span<>> BDC ( )Tj EMC (D, Xiaofeng)Tj /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ap)32(ar)-32(oscopic )]TJ 0.188 Tw -1.796 -1.25 Td [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal sigmoid col)30(ost)17(omy af)-28(ter abd)-16(omino-per)-36.9(ineal r)-24(esec)]TJ 0 Tw (-)Tj 0.023 Tw T* [(t)-32(ion for r)-24(ec)-16(t)15(al cancer.)]TJ /T1_0 1 Tf [( Gastroenterology repor)-39.9(t.)]TJ /T1_1 1 Tf ( 2014;2$1$:58\22662.)Tj 0.288 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Sj\366d)42(ahl)]TJ /Span<>> BDC ( )Tj EMC [(R, Ander)-24(ber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(B, Bol)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(T. P)40(ar)-33(ast)17.1(omal her)-14.9(nia in r)-24(el)-16(a)]TJ 0 Tw (-)Tj 0.111 Tw -1.796 -1.25 Td [(t)-32(ion )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 3.204 0 Td [(si)-24(te )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 3.013 0 Td [(t)-13(he )0.5(abd)-16(ominal )0.5(st)17(oma. )]TJ /T1_0 1 Tf 9.305 0 Td (The)Tj /Span<>> BDC ( )Tj EMC 1.713 0 Td [(Br)-37(itish )0.6(jour)-14(nal )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 7.235 0 Td [(surg)12(er)-43(y.)]TJ /T1_1 1 Tf 0 Tw ( )Tj -24.471 -1.25 Td (1988;75$4$:339\226341.)Tj 0.172 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(ill)-30.9(iams)]TJ /Span<>> BDC ( )Tj EMC [(JG, Et)-13(her)-36.9(ing)17(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(R, Ha)15(yw)-12(ar)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(MW, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(ar)-33(aileost)17.1(omy )]TJ 0.124 Tw -1.796 -1.25 Td [(her)-15(nia: a)]TJ /Span<>> BDC ( )Tj EMC [(cl)-31(inical and r)-33(adiol)30(o)-16(gical stud)17.1(y. )]TJ /T1_0 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Br)-36.9(itish jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (sur)Tj 0 Tw 27.342 0 Td (-)Tj -27.342 -1.25 Td [(g)12(er)-43(y.)]TJ /T1_1 1 Tf 0.023 Tw ( 1990;77$12$:1355\2261357.)Tj 0.073 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Et)-13(her)-36.9(ing)17(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(RJ, W)-16(ill)-31(iams)]TJ /Span<>> BDC ( )Tj EMC [(JG, Ha)15(yw)-12(ar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(MW, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Demonstr)-32.9(a)15(t)-32(ion )]TJ 0.169 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(p)32(ar)-33(a-ileost)17.1(omy her)-15(nia)15(t)-32(ion using com)10(puted t)17(omo)-16(gr)-33(aphy. )]TJ /T1_0 1 Tf 0 Tw (Clinical )Tj T* (radiology)Tj /T1_1 1 Tf 0.023 Tw (. 1990;41$5$:333\226336.)Tj 0.334 Tw T* (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Or)-22(t)-32(iz)]TJ /Span<>> BDC ( )Tj EMC [(H, Sar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(MJ, Ar)-15.9(mend)42(ar)-37(iz)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Does t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(fr)-24(equency )]TJ 0.113 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(p)32(ar)-33(a)-17(col)30(ost)17(omy her)-15(nias depend on t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(posi)-23.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(ost)17(omy )]TJ 0.194 Tw T* [(in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(abd)-16(ominal w)-12(all? )]TJ /T1_0 1 Tf [(Inter)-14(national jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (colorectal disease.)Tj /T1_1 1 Tf 0 Tw ( )Tj T* (1994;9$2$:65\22667.)Tj 0.027 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(eong)]TJ /Span<>> BDC ( )Tj EMC [(AP, L)35(ond)-15.9(ono-S)-24(chimmer)]TJ /Span<>> BDC ( )Tj EMC [(EE, Phill)-30.9(ips)]TJ /Span<>> BDC ( )Tj EMC [(RK. L)-32(ife-t)15.1(able anal)35(y)-13(sis )]TJ 0.305 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(st)17(omal com)10(pl)-31(ica)15(t)-32(ions foll)30(o)-13.9(wing ileost)17(omy. )]TJ /T1_0 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Br)-37(itish jour)-14(nal )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(surg)12(er)-42.9(y)]TJ /T1_1 1 Tf (. 1994;81$5$:727\226729.)Tj 0.038 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(ond)-16(ono-S)-24(chimmer)]TJ /Span<>> BDC ( )Tj EMC [(EE, L)35(eong)]TJ /Span<>> BDC ( )Tj EMC [(AP, Phill)-31(ips)]TJ /Span<>> BDC ( )Tj EMC [(RK. L)-31.9(ife t)15(able anal)35(y)-13(sis )]TJ 0.132 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(st)17.1(omal com)10(pl)-30.9(ica)15(t)-32(ions foll)30.1(o)-14(wing col)30(ost)17.1(omy. )]TJ /T1_0 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the colon )Tj 0.023 Tw T* (and rectum)Tj /T1_1 1 Tf (. 1994;37$9$:916\226920.)Tj 0.036 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cingi)Tj /Span<>> BDC ( )Tj EMC [(A, Cak)-15.9(ir)]TJ /Span<>> BDC ( )Tj EMC (T, Sever)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Enter)-31.9(ost)17(omy si)-24(te her)-14.9(nias: a)]TJ /Span<>> BDC ( )Tj EMC [(cl)-31(ini)]TJ 0 Tw (-)Tj 0.061 Tw -1.796 -1.25 Td [(cal and com)10(puter)-37(ized t)17(omo)-16(gr)-33(aphic ev)-15(al)35(ua)15(t)-31.9(ion. )]TJ /T1_0 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the colon )Tj 0.023 Tw T* (and rectum.)Tj /T1_1 1 Tf ( 2006;49$10$:1559\2261563.)Tj 0.04 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(il)16(gr)-36.9(im)]TJ /Span<>> BDC ( )Tj EMC [(CHC, McInt)-9.9(yr)-24(e)]TJ /Span<>> BDC ( )Tj EMC [(R, Baile)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(M. P)35(r)-32(ospec)-15.9(t)-32(i)-16(ve audi)-24(t )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ar)-33(ast)17(o)]TJ 0 Tw (-)Tj 0.014 Tw -1.796 -1.25 Td [(mal )0.5(her)-15(nia: )0.5(p)25(r)-24(ev)-14.9(alence )0.5(and )0.5(asso)-16(c)-24(ia)15(ted )0.5(comor)-23.9(bidi)-24(t)-32(ies. )]TJ /T1_0 1 Tf 21.789 0 Td [(Diseases )0.6(of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0.023 Tw -21.789 -1.25 Td (colon and rectum.)Tj /T1_1 1 Tf ( 2010;53$1$:71\22676.)Tj 0.073 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Har)-24(d)17(t)]TJ /Span<>> BDC ( )Tj EMC [(J, Se)-11(yfr)-37(ied)]TJ /Span<>> BDC ( )Tj EMC [(S, W)22(ei\337)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(pil)30(o)17(t single-centr)-23.9(e r)-32.9(and)-16(om)]TJ 0 Tw (-)Tj 0.239 Tw -1.796 -1.25 Td [(ized tr)-37(ial assessing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(safe)-11.9(t)-10(y and ef)-56(f)-28(ica)-16.9(cy of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(a)15(ter)-33(al p)32(ar)-33(ar)-23.9(ec)-16(tus )]TJ -0.047 Tw T* [(abd)-16(ominis com)10(p)32(ar)-24(ed wi)-23.9(t)-13(h tr)-33(ansr)-23.9(ec)-16(tus abd)-16(ominis muscle st)17(oma pl)-16(a)-17(ce)]TJ 0 Tw (-)Tj 0.126 Tw T* [(ment in p)32(a)15(t)-32(ients wi)-24(t)-13(h tem)10(por)-33(ar)-23.9(y l)30(o)-16(op ileost)17.1(omies: t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A)15(TRA)35.1(S)-21(T)20(OM )]TJ 0 Tw T* [(tr)-37(ial. )]TJ /T1_0 1 Tf 0.34 Tw 2.574 0 Td (Colorectal disease : the)Tj /Span<>> BDC ( )Tj EMC [(of)-40(f)-43(icial jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (the Association )Tj 0.023 Tw -2.574 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Colop)46(roctology of)]TJ /Span<>> BDC ( )Tj EMC [(Great Br)-37(itain and Ireland.)]TJ /T1_1 1 Tf ( 2016;18$2$:O81-90.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\204\021\032)50(\006\006\202\006)-21(\035\030\231)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_3 1 Tf 25 0 0 25 20.7653 56.0378 Tm (102)Tj ET endstream endobj 538 0 obj [554 0 R 555 0 R] endobj 539 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 332.0332 42.7216 Tm [(Does th)11.1(e\022par)21(astomal h)11(ernia r)21(ate depend on th)11(e\022meth)11(od )]TJ 2.996 -1 Td [(of\022stoma formation? $meta-analy)10(sis and r)31(e)11(vie)11(w$)]TJ -41.598 1 Td [(\231\005\016\b\205\b\026 \013\b \017\005\001\016\b\026\b\f \223\005\017\005\ \205)-10(\026)11(\025\024\005\013\n\t\025\255 )]TJ 0 -1 TD [(\020\017\240\235\b \025\026\022\205\223\025\205\025\210\005 \211\025\017\ \024\b\017\025\016\005\t\b \205)-10(\026)11(\025\024\240? )]TJ T* [($\024\f\026)11(\005\005\t\005\013\b\001\022\b\022\205\b\205)-10(\026)11(\f\024\005\026\b\213\f\205\007\b\255 \025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 10 0 0 10 42.5197 724.8299 Tm [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \214)6.6(\022)-12.3(\027)1.7(\007)1.3(\021\034\036)]TJ /Span<>> BDC 3.462 0 Td ( )Tj EMC [(\225)16.6(.)33.7(\002)-12.1(.)-2.1(,)-10( \210)2.2(\016)-10.9(\033)-4.6(\020)-2.3(\032\004)-6.6(\034\036)]TJ /Span<>> BDC 6.625 0 Td ( )Tj EMC [(\002)-12.1(.)18.5(\215)14.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -17.781 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.795 Tw [( \240)7.3(\034)-0.8(\024)4(\021)12.7(\037)-5.2(\027)3.3(\016)6.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\213)-2.3(.)29.4(\235)28.8(.)7.8(, \214)16.6(\022)-2.3(\027)11.6(\007)11.3(\021)9.8(\034)9.6(\036)]TJ /Span<>> BDC ( )Tj EMC [(\225)26.6(.)43.7(\002)-2.1(.)7.9(, )]TJ -0.01 Tc 0.01 Tw 0 -1.218 TD [(\210)2.2(\016)-10.9(\033)-4.6(\020)-2.3(\032\004)-6.7(\034\036)]TJ /Span<>> BDC 4.233 0 Td ( )Tj EMC [(\002)-12.1(.)18.5(\215)14.3(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -4.233 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf -0.065 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf -0.002 Tc -0.063 Tw [( S)14.3(ta)-2.8(n)4.2(i)9(s)7.3(l)1.3(a)-6.4(v)]TJ /Span<>> BDC 16.68 0 Td ( )Tj EMC [(V)51.1(.)]TJ /Span<>> BDC 0.89 0 Td ( )Tj EMC [(C)1.2(he)-3.7(r)-16.6(n)4.2(y)-3(s)7.6(ho)-2.6(v)]TJ /T1_1 1 Tf 0 Tc 0.073 Tw -17.57 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-47.9(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf [( Y)33.6(u)6.2(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)6.2(i)7.4(l)-6.3(k)12.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(N)8.6(u)6.1(r)-35.3(iy)3.8(a)-4.8(t)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)-5.9(d)5.2(u)2.8(ll)3.4(a)-5.9(y)0.9(e)-4(v)10.8(a)]TJ /T1_1 1 Tf -0.007 Tc 1.725 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf 0 Tc 1.718 Tw 10.806 0 Td [( Y)33.7(u)6.1(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)6.2(i)7.4(l)-6.3(k)12.9(o)-0.6(v)33.7(, )]TJ -0.002 Tc 0.002 Tw -10.806 -1.218 Td [(S)14.3(ta)-2.8(n)4.2(i)9(s)7.3(l)1.4(a)-6.4(v)]TJ /Span<>> BDC 3.506 0 Td ( )Tj EMC [(V)51.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(C)1.2(he)-3.7(r)-16.6(n)4.2(y)-2.9(s)7.6(ho)-2.6(v)]TJ /T1_1 1 Tf -0.052 Tc 0.052 Tw -4.461 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 5.233 0 Td [( Y)33.7(u)6.1(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)6.2(i)7.4(l)-6.3(k)12.9(o)-0.6(v)33.6(, S)16.4(t)2.3(a)-0.8(n)6.2(i)11(s)9.3(l)3.3(a)-4.4(v)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(C)3.2(h)1.9(e)-1.7(r)-14.6(n)6.2(y)-1(s)9.6(h)1.9(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -5.233 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.796 Tw 3.238 0 Td [( )0.6(A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC 4.998 0 Td [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC 1.659 0 Td [(M)2.3(o)3.3(s)9.1(k)15.8(al)4.9(e)-4(v)33.6(, )0.5(Y)33.7(u)6.1(r)-40.1(y)]TJ /Span<>> BDC ( )Tj EMC 7.417 0 Td [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC 1.785 0 Td [(K)0.7(h)6.2(i)7.4(l)-6.3(k)12.9(ov)33.6(, )]TJ -0.002 Tc 0.002 Tw -19.097 -1.218 Td [(S)14.3(ta)-2.8(n)4.2(i)9(s)7.3(l)1.4(a)-6.4(v)]TJ /Span<>> BDC 3.506 0 Td ( )Tj EMC [(V)51.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(C)1.2(he)-3.7(r)-16.6(n)4.2(y)-2.9(s)7.6(ho)-2.6(v)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 18.783 14.614 Td (\255\026\036\031\036\025\034\222 \017\225 \032\026\020\017\022\032\233 $\ ORCID$)Tj /T1_1 1 Tf 0 Tw T* (\231\036\030\027\t\001\024\r \225.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* (\216\017\035\034\022\024\r \222.\225.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-3746-5218)Tj T* (\204\024\f\022\026\035\036\r \202.\230.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-3038-1524)Tj T* (\202\002\007\031\035\026\036\r\026 \203.\225.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0000-2854-397X)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS $ORCID$)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(S)15(t)15(anisl)-16(av V.)]TJ /Span<>> BDC ( )Tj EMC [(Cher)-14.9(ny)-12.9(shov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-6212-9454)Tj T* [(Y)35(ur)-24(y S.)]TJ /Span<>> BDC ( )Tj EMC (Khilkov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-3746-5218)Tj T* [(Alek)-10(se)-10.9(y I.)]TJ /Span<>> BDC ( )Tj EMC [(M)-24(osk)-16.9(alev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3038-1524)Tj T* [(Nur)-37(iy)22(a)15.1(t S. A)-14(bdull)-15.9(a)15(yev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0000-2854-397X)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 542.1599 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\223\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.359 Tw 8 0 0 8 42.5197 529.3252 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.325 0 Td [(\202\004\022\026)0.5(\f\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\225.\230., \200\026\030\007\026\027\016)0.5(\027)]TJ /Span<>> BDC ( )Tj EMC [(\202.\200)0.5(., \025\026\035)0.5(\026\001)0.5(\027\017\022\024\r\026)]TJ /Span<>> BDC ( )Tj EMC [(\230)0.5(.\202., \017)]TJ /Span<>> BDC 23.113 0 Td ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0 Tc 0.345 Tw -24.438 -1.25 Td [(\025\017\001\036\004\027\t\036 )0.5(\f\021\024\n\t: )0.6(\030\031\022\024\r\024\007\f\021\r\024 )0.5(\007\035\016 )0.5(\r\030\026\004\036\005. )0.6(\204\024\f\022\r\026: )0.5(\210\002\013\036\f\021\r\024 )]TJ 0.114 Tw 0 -1.25 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\024\020\030\026\027\017\004\036\027\027\024\005 \024\021\r\036\021\f\021\ \r\036\027\027\024\f\021\034\033 \230\007\026\021\036\035\034\f\022\026\ \016 \020\030\031\023\023\026 \253\206\237\210\224\202\217-)Tj 0.293 Tw T* [(\204\036\007\017\026\273. 2021;304 \f. ISBN 978-5-9704-6469-4. / A)-25(chk)-16.9(asov)]TJ /Span<>> BDC ( )Tj EMC (S.I., )Tj 0.1 Tw T* [(V)25(ar)-24(d)42(any)22(an)]TJ /Span<>> BDC ( )Tj EMC [(A.V., K)-15.9(al)-16(ashnikov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(I.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Intest)-31.9(inal st)17(omas: a)]TJ /Span<>> BDC ( )Tj EMC (guide )Tj 0.193 Tw T* [(for d)-16(o)-15.9(c)-16(t)17(or)-10(s. M)-23.9(osco)-14(w: L)-32(imi)-23.9(ted L)-32(iabil)-31(i)-23.9(t)-10(y Com)10(p)32(any P)20.1(ubl)-31(ishing G)20(r)-32(oup )]TJ 0.173 Tw T* [(GEOT)35(AR-Media. 2021;304 p. $in Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33029/9704-6469-)Tj T* [(4-K)-25(S-2021-1-304)]TJ 0 0 0 1 k /GS1 gs 0.04 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Ambe)Tj /Span<>> BDC ( )Tj EMC [(PC, K)25(ur)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(NR, Ni)-24(tschk)10.1(e)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Intest)-31.9(inal Ost)17(omy. )]TJ /T1_2 1 Tf 0 Tw (Deutsches )Tj 0.023 Tw -1.296 -1.25 Td [(Ar)-16(zteblatt inter)-14(national. )]TJ /T1_1 1 Tf 0 Tw (2018;115$11$:182\226187.)Tj -0.025 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ma)15(ydick)]TJ /Span<>> BDC ( )Tj EMC (D. A)Tj /Span<>> BDC ( )Tj EMC [(Descr)-37(ipt)-31.9(i)-16(ve S)15(tud)17(y Assessing Q)-16(ual)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ife for A)15(dul)56(ts )]TJ 0.09 Tw -1.296 -1.25 Td [(W)-16(i)-24(t)-12.9(h a)]TJ /Span<>> BDC ( )Tj EMC [(P)30.1(er)-16(manent Ost)17(omy and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Infl)35(uence of)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-24(eoper)-32.9(a)15(t)-32(i)-16(ve S)15(t)17(oma )]TJ 0.023 Tw T* [(S)-16(i)-24(te Mar)-24(k)-16(ing.)]TJ /T1_2 1 Tf [( Ostom)11.1(y/w)12(ound manag)12.1(ement.)]TJ /T1_1 1 Tf ( 2016;62$5$:14\22624.)Tj 0.104 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(edder)-15(n M-L, Emmer)-21.9(tsen)]TJ /Span<>> BDC ( )Tj EMC [(K)20(J, L)-32(aur)-24(ber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(S. L)-31.9(ife wi)-24(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC [(st)17(oma af)-28(ter )]TJ 0.124 Tw -1.296 -1.25 Td [(cur)-33(a)15(t)-31.9(i)-16(ve r)-24(esec)-16(t)-32(ion for r)-24(ec)-16(t)15(al cancer: a)]TJ /Span<>> BDC ( )Tj EMC [(popul)-16(a)15(t)-31.9(ion-based cr)-32(oss-sec)]TJ 0 Tw (-)Tj -0.005 Tw T* [(t)-32(ional )0.6(stud)17(y. )]TJ /T1_2 1 Tf 5.342 0 Td [(Colorectal )0.7(disease )0.6(: )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 9.207 0 Td [(of)-40(f)-43(icial )0.6(jour)-14(nal )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 7.119 0 Td [(the )0.6(Association )]TJ 0.202 Tw -21.667 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Colop)46(roctology of)]TJ /Span<>> BDC ( )Tj EMC [(Great Br)-36.9(itain and Ireland.)]TJ /T1_1 1 Tf ( 2015;17$11$:1011\226)Tj 0 Tw T* (1017.)Tj 0.17 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ma)-17(gl)-31(io)]TJ /Span<>> BDC ( )Tj EMC 3.118 0 Td [(A, )0.5(Mal)30.1(vone)]TJ /Span<>> BDC ( )Tj EMC 4.833 0 Td [(AP, )0.6(S)-24(cadut)17(o)]TJ /Span<>> BDC ( )Tj EMC 5.295 0 Td [(V, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.321 0 Td [(al. )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.223 0 Td [(fr)-24(equency )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 5.608 0 Td [(ear)-30(l)35(y )]TJ 0.054 Tw -25.694 -1.25 Td [(st)17(omal, per)-37(ist)17.1(omal and sk)-15.9(in com)10(pl)-30.9(ica)15(t)-32(ions. )]TJ /T1_2 1 Tf [(Br)-37(itish jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (nursing )Tj 0.023 Tw T* ($Mark Allen Publishing$.)Tj /T1_1 1 Tf ( 2021;30$22$:1272\2261276.)Tj 0.063 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mal)-31(ik)]TJ /Span<>> BDC ( )Tj EMC [(T, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC [(MJ, Har)-36.9(ikr)-37(ishnan)]TJ /Span<>> BDC ( )Tj EMC [(A)44(B. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(inc)-24(idence of)]TJ /Span<>> BDC ( )Tj EMC [(st)17.1(oma r)-24(el)-16(a)15(ted )]TJ 0.169 Tw -1.296 -1.25 Td [(mor)-24(bidi)-23.9(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-24(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omised contr)-32(olled tr)-37(ials. )]TJ /T1_2 1 Tf -0.008 Tw T* (Annals of)Tj /Span<>> BDC ( )Tj EMC [(the R)19(o)12(yal Colleg)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(eons of)]TJ /Span<>> BDC ( )Tj EMC [(Eng)13(land.)]TJ /T1_1 1 Tf ( 2018;100$7$:501\226)Tj 0 Tw T* (508.)Tj 0.132 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cor)-24(r)-23.9(ea Mar)-36.9(inez)]TJ /Span<>> BDC ( )Tj EMC [(A, Bo)-16(ck)]TJ /Span<>> BDC ( )Tj EMC [(D, Car)-30(lsson)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(t)17(oma-r)-23.9(el)-16(a)15(ted com)]TJ 0 Tw (-)Tj 0.225 Tw -1.296 -1.25 Td [(pl)-31(ica)15(t)-32(ions: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(epor)-21.9(t fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 12.805 0 Td [(S)15(t)17(oma-Const )0.5(r)-33(and)-16(omized contr)-31.9(olled )]TJ 0 Tw -12.805 -1.25 Td [(tr)-37(ial. )]TJ /T1_2 1 Tf 0.34 Tw 2.574 0 Td (Colorectal disease : the)Tj /Span<>> BDC ( )Tj EMC [(of)-40(f)-43(icial jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (the Association )Tj 0.274 Tw -2.574 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Colop)46(roctology of)]TJ /Span<>> BDC ( )Tj EMC [(Great Br)-36.9(itain and Ireland.)]TJ /T1_1 1 Tf ( 2021;23$5$:1091\226)Tj 0 Tw T* (1101.)Tj 0.212 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(habbir)]TJ /Span<>> BDC ( )Tj EMC [(J, Br)-37(i)-24(t)-30(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(DC. S)15(t)17(oma com)10(pl)-30.9(ica)15(t)-32(ions: a)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-23.9(ter)-33(a)15(tur)-23.9(e over)]TJ 0 Tw 25.99 0 Td (-)Tj -27.286 -1.25 Td [(v)-16(iew. )]TJ /T1_2 1 Tf 0.326 Tw 2.691 0 Td (Colorectal disease : the)Tj /Span<>> BDC ( )Tj EMC [(of)-39.9(f)-43(icial jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (the Association )Tj 0.017 Tw -2.691 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Colop)46(roctology of)]TJ /Span<>> BDC ( )Tj EMC [(Great Br)-37(itain and Ireland.)]TJ /T1_1 1 Tf ( 2010;12$10$:958\226964.)Tj 0.007 Tc 0.35 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.317 0 Td [(Col)29.9(v)-16.1(in)]TJ /Span<>> BDC ( )Tj EMC [(J, R)10.9(osenbl)-16.1(a)14.9(t)-30.1(t)]TJ /Span<>> BDC ( )Tj EMC [(S. Sur)-32.1(gical Mana)-17.1(gement of)]TJ /Span<>> BDC ( )Tj EMC [(P)39.9(ar)-33.1(ast)16.9(omal)7( )]TJ 0 Tc 0 Tw -1.317 -1.25 Td [(Her)-15(nias. )]TJ /T1_2 1 Tf 0.023 Tw 3.61 0 Td (The)Tj /Span<>> BDC ( )Tj EMC (Surgical clinics of)Tj /Span<>> BDC ( )Tj EMC [(N)17(or)-39.9(th Amer)-37(ica. )]TJ /T1_1 1 Tf 0 Tw (2018;98$3$:577\226592.)Tj 0.047 Tw -3.61 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gol)-31(igher)]TJ /Span<>> BDC ( )Tj EMC [(JC. E)35(xtr)-33(aper)-36.9(i)-24(t)17(oneal col)30(ost)17(omy or ileost)17.1(omy. )]TJ /T1_2 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Br)-37(itish )]TJ 0.023 Tw -1.796 -1.25 Td [(jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(surg)12(er)-43(y)]TJ /T1_1 1 Tf (. 1958;46$196$:97\226103.)Tj 0.016 Tc 0.588 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.861 0 Td (\213\030\024\023\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\215.\200., \221\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\225.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)16( )]TJ 0.019 Tc 0.675 Tw -1.861 -1.25 Td [(\215\030\024\235)0.5(\017\035\026\022\021\017\022\026 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\022\024\027\006\036\r\024\005 )0.5(\022\024\035\024\f\021\024\n\t. )0.6(\204\024\f\022\r\026:)19( )]TJ 0 Tc 0.269 Tw T* [(\230\007\026\021\036\035\034\f\021\r\024 )0.6(\233\204\036\007\017\006\017\027\026\234. )0.5(1991; )0.5(17 )0.5(\f. )0.5(/ )0.5(Er)-32(opk)-16(in)]TJ /Span<>> BDC ( )Tj EMC 21.916 0 Td [(P.V., )0.5(S)-16(hel)35(ygin )]TJ 0.231 Tw -21.916 -1.25 Td [(Y)35(u.A., F)10(r)-31.9(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(event)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(ter)-16(minal )]TJ 0.157 Tw T* [(col)30(ost)17(omy. M)-24(osco)-13.9(w: P)20(ubl)-30.9(ishing house \233Medic)-23.9(ine\234. 1991; 17 p. $in )]TJ 0 Tw T* (Russ.$.)Tj 0.051 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(ian)]TJ /Span<>> BDC ( )Tj EMC [(L, W)16(u X-R, He X-S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-32.9(aper)-37(i)-24(t)17(oneal vs. intr)-32.9(aper)-37(i)-24(t)17(oneal )]TJ 0.146 Tw -1.796 -1.25 Td [(r)-32(oute )0.5(for )0.5(per)-16(manent )0.6(col)30(ost)17(omy: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC 14.362 0 Td [(me)-12(t)15(a-anal)35.1(y)-13(sis )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 7.108 0 Td [(1,071 )0.5(p)32(a)15(t)-32(ients. )]TJ /T1_2 1 Tf 0.023 Tw 7.585 55 Td [(Inter)-14(national jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (colorectal disease.)Tj /T1_1 1 Tf ( 2012;7$1$:59\22664.)Tj 0.099 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(ak)-17(ahashi)]TJ /Span<>> BDC ( )Tj EMC [(H, T)40(ak)-16.9(asu)]TJ /Span<>> BDC ( )Tj EMC [(K, Nak)-17(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(ap)32(ar)-32(oscopic e)-18(xtr)-33(aper)-36.9(i)]TJ 0 Tw (-)Tj 0.186 Tw -1.796 -1.25 Td [(t)17(oneal sigmoid col)30(ost)17(omy using t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(t)17(o)17(t)15(all)35(y e)-18(xtr)-33(aper)-36.9(i)-24(t)17(oneal her)-15(nia )]TJ 0.03 Tw T* [(r)-24(ep)32(air technique af)-27.9(ter abd)-16(ominoper)-37(ineal r)-24(esec)-15.9(t)-32(ion for r)-23.9(ec)-16(t)15(al cancer. )]TJ /T1_2 1 Tf 0.023 Tw T* [(Surg)12(er)-43(y tod)26(ay.)]TJ /T1_1 1 Tf ( 2019;49$11$:977\226980.)Tj 0.001 Tc 0.35 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.8 0 Td [(Sugar)-24(bak)10(er)]TJ /Span<>> BDC ( )Tj EMC 5.059 0 Td [(PH. )0.5(P)35(r)-32(ost)-13(he)-12(t)-32.1(ic )0.5(mesh )0.5(r)-24(ep)31.9(air )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 13.78 0 Td [(l)-16(ar)-32.1(ge )0.5(her)-15(nias )0.5(a)15(t)1( )]TJ 0.011 Tc 0.402 Tw -20.639 -1.25 Td [(t)-12.8(he)]TJ /Span<>> BDC ( )Tj EMC [(si)-23.8(te of)]TJ /Span<>> BDC ( )Tj EMC [(col)30.2(onic st)17.2(omas. )]TJ /T1_2 1 Tf [(Surg)12.1(er)-42.8(y, gynecology & obstetr)-36.8(ics.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj -27.638 -1.25 Td (1980;150$4$:576\226578.)Tj 0.317 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (L\363pez-Cano)Tj /Span<>> BDC ( )Tj EMC [(M, A)15(dell-T)50(r)-33(ap\351)]TJ /Span<>> BDC ( )Tj EMC [(M, V)29.9(er)-23.9(d)42(a)-17(guer-T)50(r)-24(emol)30(osa)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.181 Tw -1.796 -1.25 Td [(P)40(ar)-33(ast)17.1(omal her)-14.9(nia p)25(r)-24(event)-31.9(ion wi)-23.9(t)-13(h per)-16(manent mesh in end col)30(os)]TJ 0 Tw (-)Tj 0.216 Tw T* [(t)17(omy: f)16(ail)35.1(ur)-24(e wi)-24(t)-12.9(h l)-16(a)15(te foll)30(o)-13.9(w-up of)]TJ /Span<>> BDC ( )Tj EMC [(cohor)-22(ts in t)-13(hr)-23.9(ee r)-33(and)-16(omized )]TJ 0 Tw T* [(tr)-37(ials. )]TJ /T1_2 1 Tf 0.192 Tw 2.815 0 Td [(Her)-14(nia : the)]TJ /Span<>> BDC ( )Tj EMC [(jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(her)-13.9(nias and abdominal w)13(all surg)12(er)-42.9(y.)]TJ /T1_1 1 Tf 0 Tw ( )Tj -2.815 -1.25 Td (2023;27$3$:657\226664.)Tj 0.264 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Eldr)-22(up)]TJ /Span<>> BDC ( )Tj EMC [(J, W)-16(ied)]TJ /Span<>> BDC ( )Tj EMC [(U, Bischof)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)10(ost-col)30.1(ost)17(omy her)-15(nias. )]TJ 0.044 Tw -1.796 -1.25 Td [(Inc)-24(idence and r)-24(el)-15.9(a)15(t)-32(ion t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(pl)-16(a)-17(c)-24(ing of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he st)17(oma. )]TJ /T1_2 1 Tf [(Ug)12(eskr)-36.9(if)-46(t for laeg)12(er.)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* (1982;144$50$:3742\2263743.)Tj 0.211 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Har)-24(d)17(t)]TJ /Span<>> BDC ( )Tj EMC [(J, Meer)-23.9(pohl)]TJ /Span<>> BDC ( )Tj EMC [(JJ, Me)-12(tzend)-16(or)-23.9(f M-I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-32(a)15(ter)-32.9(al p)32(ar)-33(ar)-23.9(ec)]TJ 0 Tw (-)Tj 0.341 Tw -1.796 -1.25 Td [(t)15(al ver)-9.9(sus tr)-32.9(ansr)-24(ec)-16(t)15(al st)17(oma pl)-16(a)-16.9(cement for p)25(r)-24(event)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ar)-33(a)]TJ 0 Tw (-)Tj 0.327 Tw T* [(st)17(omal her)-15(nia)15.1(t)-32(ion. )]TJ /T1_2 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Cochrane d)26(atabase of)]TJ /Span<>> BDC ( )Tj EMC [(systematic revie)10.1(ws.)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* (2019;4$4$:CD009487.)Tj 0.137 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(iber)-32.9(a)15(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Al)56.1(tman)]TJ /Span<>> BDC ( )Tj EMC [(DG, T)40(e)-12(tzl)-15.9(af)-56(f)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(PRISMA st)15(a)15(tement )]TJ 0.108 Tw -1.796 -1.25 Td [(for r)-23.9(epor)-22(t)-32(ing sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iews and me)-12(t)15(a-anal)35(y)-13(ses of)]TJ /Span<>> BDC ( )Tj EMC [(studies t)-13(ha)15(t )]TJ 0.26 Tw T* [(ev)-15(al)35(ua)15(te heal)56(t)-12.9(h car)-23.9(e inter)-31.9(vent)-32(ions: e)-18(xpl)-16(ana)15(t)-31.9(ion and el)-16(abor)-33(a)15(t)-31.9(ion. )]TJ /T1_2 1 Tf 0.023 Tw T* (PLoS medicine.)Tj /T1_1 1 Tf ( 2009;6$7$:e1000100\226e1000100.)Tj 0.292 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hammond)Tj /Span<>> BDC ( )Tj EMC 4.559 0 Td [(TM, )0.6(Huang)]TJ /Span<>> BDC ( )Tj EMC 4.973 0 Td [(A, )0.6(P)35(r)-32(osser)]TJ /Span<>> BDC ( )Tj EMC 4.671 0 Td [(K, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.583 0 Td [(al. )0.6(P)40(ar)-33(ast)17(omal )0.6(her)-15(nia )]TJ 0.048 Tw -18.582 -1.25 Td [(p)25(r)-24(event)-31.9(ion using a)]TJ /Span<>> BDC ( )Tj EMC [(novel coll)-16(a)-17(gen im)10(pl)-15.9(ant: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omised contr)-32(olled )]TJ 0.175 Tw T* [(phase 1 stud)17(y. )]TJ /T1_2 1 Tf [(Her)-14(nia : the)]TJ /Span<>> BDC ( )Tj EMC [(jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(her)-13.9(nias and abdominal w)13(all )]TJ 0 Tw T* [(surg)12(er)-43(y.)]TJ /T1_1 1 Tf 0.023 Tw ( 2008;12$5$:475\226481.)Tj 0.006 Tc 0.349 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.819 0 Td [(Ser)-23.7(r)-32.7(a-Ar)-32.7(a)-16.7(c)-23.7(il)]TJ /Span<>> BDC ( )Tj EMC [(X, Bombar)-23.7(d)-15.7(o-Junca)]TJ /Span<>> BDC ( )Tj EMC [(J, M)-23.7(or)-23.7(eno-Ma)15.3(t)-31.7(ias)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-11.6(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)6( )]TJ 0 Tc -0.015 Tw -1.819 -1.25 Td [(R)-10(and)-16(omized, )0.5(contr)-32(olled, )0.5(p)25(r)-32(ospec)-16(t)-32(i)-15.9(ve tr)-36.9(ial of)]TJ /Span<>> BDC ( )Tj EMC 17.764 0 Td [(t)-13(he )0.5(use of)]TJ /Span<>> BDC ( )Tj EMC 4.193 0 Td (a)Tj /Span<>> BDC ( )Tj EMC [(mesh )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-23.9(e)]TJ 0 Tw (-)Tj 0.023 Tw -21.956 -1.25 Td [(vent p)32(ar)-32.9(ast)17(omal her)-15(nia. )]TJ /T1_2 1 Tf (Annals of)Tj /Span<>> BDC ( )Tj EMC [(surg)12.1(er)-43(y. )]TJ /T1_1 1 Tf 0 Tw (2009;249$4$:583\226587.)Tj 0.103 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (J\344nes)Tj /Span<>> BDC ( )Tj EMC (A, Cengiz)Tj /Span<>> BDC ( )Tj EMC [(Y, Isr)-33(aelsson)]TJ /Span<>> BDC ( )Tj EMC [(L)-35(A. P)35(r)-24(event)-31.9(ing p)32(ar)-32.9(ast)17(omal her)-14.9(nia )]TJ 0.114 Tw -1.796 -1.25 Td [(wi)-24(t)-12.9(h a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ost)-12.9(he)-12(t)-32(ic mesh: a)]TJ /Span<>> BDC ( )Tj EMC [(5-year foll)30(o)-14(w-up of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized stud)17.1(y. )]TJ /T1_2 1 Tf 0.023 Tw T* [(W)29(orld jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(surg)12(er)-43(y.)]TJ /T1_1 1 Tf ( 2009;33$1$:113\226118.)Tj 0.235 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(V)30(ent)-13(ham)]TJ /Span<>> BDC ( )Tj EMC 3.991 0 Td [(NT, )0.6(Br)-33(ad)17(y)]TJ /Span<>> BDC ( )Tj EMC 4.455 0 Td [(RR, )0.6(S)14.9(tew)-11.9(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC 5.235 0 Td [(RG, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.015 0 Td [(al. )0.6(P)35(r)-32(ophyl)-16(a)-17(c)-16(t)-32(ic )0.6(mesh )]TJ 0.28 Tw -18.492 -1.25 Td [(pl)-16(a)-17(cement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.06 0 Td [(per)-16(manent )0.5(st)17.1(omas a)15(t )0.5(inde)-18(x )0.5(oper)-33(a)15(t)-32(ion )0.5(for )0.5(col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.311 Tw -6.06 -1.25 Td [(t)15(al cancer. )]TJ /T1_2 1 Tf [(Annals )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(the R)19(o)12(yal Colleg)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(eons of)]TJ /Span<>> BDC ( )Tj EMC [(Eng)13(land.)]TJ /T1_1 1 Tf 0 Tw ( )Tj T* (2012;94$8$:569\226573.)Tj 0.065 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (L\363pez-Cano)Tj /Span<>> BDC ( )Tj EMC [(M, L)35(ozoy)22(a-T)50(r)-22(ujill)30.1(o)]TJ /Span<>> BDC ( )Tj EMC [(R, Q)-16(uir)-32(o)-16(ga)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Use of)Tj /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(os)]TJ 0 Tw (-)Tj 0.007 Tc 0.349 Tw -1.796 -1.25 Td [(t)-12.5(h)0.5(e)-11.5(t)-31.4(i)0.5(c m)0.5(e)0.5(s)0.5(h)0.5( t)17.5(o)]TJ /Span<>> BDC 6.65 0 Td ( )Tj EMC [(p)25.5(r)-23.5(e)0.6(v)0.5(e)0.5(n)0.5(t)0.5( p)32.5(a)0.5(r)-32.5(a)0.5(s)0.5(t)17.5(o)0.5(m)0.5(a)0.5(l)0.5( h)0.5(e)0.5(r)-14.5(n)0.5(i)0.5(a)0.5( d)0.5(u)0.5(r)-36.5(i)0.5(n)0.6(g l)-15.5(a)0.5(p)32.5(a)0.5(r)-31.5(o)0.5(s)0.5(c)0.5(o)0.5(p)0.5(i)0.5(c)7( )]TJ 0 Tc 0.056 Tw -6.65 -1.25 Td [(abd)-16(ominoper)-36.9(ineal r)-24(esec)-15.9(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized contr)-31.9(olled tr)-36.9(ial. )]TJ /T1_2 1 Tf [(Her)-14(nia : )]TJ 0.094 Tw T* (the)Tj /Span<>> BDC ( )Tj EMC [(jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(her)-14(nias and abdominal w)13(all surg)12(er)-43(y. )]TJ /T1_1 1 Tf 0 Tw (2012;16$6$:661\226)Tj T* (667.)Tj 0.002 Tc 0.349 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.803 0 Td [(T\342r)-31.7(coveanu)]TJ /Span<>> BDC ( )Tj EMC [(E, V)25.2(asilescu)]TJ /Span<>> BDC ( )Tj EMC [(A, Co)17.2(tea)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40.3(ar)-32.8(ast)17.2(omal her)]TJ 0 Tc 0 Tw 25.483 0 Td (-)Tj 0.011 Tw -27.286 -1.25 Td (nias)Tj /Span<>> BDC ( )Tj EMC [(\227 cl)-31(inical stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(her)-33(apeut)-32(ic str)-33(a)15(tegies. )]TJ /T1_2 1 Tf (Chirurgia \(Bucharest, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\204\021\032)50(\006\006\202\006)-21(\035\030\231)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 504.6522 56.0378 Tm (101)Tj ET endstream endobj 554 0 obj <>/Border[0 0 0]/H/N/Rect[192.078 476.621 263.622 467.325]/Subtype/Link/Type/Annot>> endobj 555 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 466.621 97.8312 457.325]/Subtype/Link/Type/Annot>> endobj 557 0 obj <> endobj 556 0 obj <> endobj 27 0 obj <> endobj 28 0 obj <> endobj 29 0 obj <> endobj 30 0 obj <> endobj 31 0 obj <> endobj 578 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 579 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 580 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 581 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 582 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 600 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.188 Tw 10 0 0 10 70.8661 724.8299 Tm (\200)Tj /Span<>> BDC ( )Tj EMC [(2005 \020\024\007\031 L)35(er)-32(oy J. \023\030\036\007\035\024\032\017\035 \n\036\021\024\007\017\022\031\ , \022\024\021\024\030\026\016 )]TJ 0.839 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\024\005 \002\030\ \033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\024\005 )Tj 0.228 Tw T* (\220\022\f\021\017\030\023\026\006\017\017 \023\030\036\007\023\024\035\026\ \020\026\036\021 \r\b\024\007 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\023\036\030\017\021\024\027\036\026\035\034)Tj 0 Tw (-)Tj 0.004 Tw T* (\027\024\036 \023\030\024\f\021\030\026\027\f\021\r\024, \030\026\f\f\036\ \022\026\016 \026\007\027\017\005 \035\017\f\021\024\022 \026\023\024\027\ \036\r\030\024)Tj 0 Tw (-)Tj 0.049 Tw T* (\026 \023\030\016\n\024\005 \n\t\001\006\t \023\024\007 \022\024\f\t\n \ \031\020\035\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\036\031 \023\036\030\036\007)Tj 0 Tw (-)Tj 0.023 Tw T* [(\027\036\020\024 \035\017\f\021\022\026 )0.5(\026\023\024\027\036\r\030\024\026, \002\035\017\032\036 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\035\026\021\036\030\026\035\034\027\024\005 )0.5(\f\021\036\027\022\036 )]TJ 0.046 Tw 0 -1.218 TD [(\r\035\026\020\026\035\017\013\026 )0.6(\023\030\016\n\024\005 )0.5(\n\t\001\006\t. )0.6(\224\026\022\017\n )0.5(\024\002\030\026\024\n )0.6(\235\024\030\n\017\030\031)]TJ 0 Tw (-)Tj 0.11 Tw 0 -1.218 TD (\036\021\f\016 \021\030\026\027\f\030\036\022\021\026\035\034\027\t\005 \ \022\026\027\026\035, \022\024\021\024\030\t\005 \024\002\030\026\031\036\ \021 \031\020\024\035 )Tj 0.152 Tw T* (\002\035\017\022\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (90)Tj 0 Tw 5.83 0 0 5.83 127.4089 630.7358 Tm (0 )Tj 0.152 Tw 10 0 0 10 132.5695 627.4058 Tm [([37]. Hamad)42.1(a)]TJ /Span<>> BDC ( )Tj EMC (M. \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\005 \030\026\002\024\021\036 \r\024\f)Tj 0 Tw (-)Tj 0.007 Tw -6.17 -1.218 Td (\023\030\024\017\r\036\035 \220\021\024\021 \n\036\021\024\007 [36]. \200\ )Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b 2 \r\022\035\033\004\036\027\027\t\b )Tj 0.326 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\b \026\r\021\024\030\t \r\024\ \f\023\030\024\017\r\024\007\017\035\017 \030\026\035\017\004\027\t\036\ )Tj 0.206 Tw T* [(\n\024\007\017\235\017\022\026\006\017\017 )0.6(\220\021\024\020\024 )0.5(\n\036\021\024\007\026. )0.6(\224\026\022, )0.5(Dong )0.5(\235\024\030\n\017\030\024\r\026\035 )]TJ 0.274 Tw T* (\f\021\024\n\026\035\034\027\t\005 \022\026\027\026\035 \023\026\030\026\ \030\036\022\021\026\035\034\027\024, \030\026\f\f\035\026\017\r\026\016\ \r\027\031)Tj 0 Tw (-)Tj -0.02 Tw T* [(\021\030\036\027\027\033\033 )0.6(\022\024\f\031\033 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.394 0 Td [(\023\024\023\036\030\036\004\027\t\036 )0.6(\n\t\001\006\t )0.5([35]. )0.5(Heiying)]TJ /Span<>> BDC ( )Tj EMC 13.969 0 Td (J. )Tj 0.724 Tw -21.363 -1.218 Td (\024\f\031\013\036\f\021\r\035\016\035 \021\030\026\027\f\030\036\022\021\ \026\035\034\027\t\005 \007\024\f\021\031\023, \023\030\024\027\017\022\026\ \035 )Tj 0.089 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\030\026\027\f\021\r\024 \n\036\032\007\031 \r\027\031\ \021\030\036\027\027\036\005 \022\024\f\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\024\005 \n\t\001\006\036\005, \030\026\f\f\036\022\026\035 \002\030\ \033\001\017\027\031 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\r\024\n \035\026\021\036\030\026\035\034\027\024\n )Tj 0.01 Tw T* [(\022\026\027\026\035\036, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\021\024\n )0.5(\031\001\017\r\026\035 \007\036\235\036\022\021 )0.5(\n\t\001\006\t )0.5(\r\n\036\f\021\036 \f)]TJ /Span<>> BDC ( )Tj EMC (\002\030\033)Tj 0 Tw (-)Tj T* (\001\017\027\024\005 \023\024\f\035\036 \023\030\024\r\036\007\036\027\017\ \016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\036\n\031 \022\017\001\022\017.)Tj 0.06 Tw T* (\217\036\031\035\034\021\026\021\t \n\036\021\026\026\027\026\035\017\026\ \023\024\007\021\r\036\030\032\007\026\033\021 \020\017\023\024\021\036\ \031, \004\021\024 )Tj 0.397 Tw T* [(\220\021\024\021 )0.5(\f\023\024\f\024\002 )0.6(\235\024\030\n\017\030\024\r\026\027\017\016 )0.5(\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\024\ \005 )]TJ 0.158 Tw T* (\f\021\024\n\t \007\024\f\021\024\r\036\030\027\024 \f\027\017\032\026\036\ \021 \004\026\f\021\024\021\031 \023\026\030\026\f\021\024\n\026\035\034\ \027\t\b )Tj 0.107 Tw T* (\020\030\t\032 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \023\026\030\026\f\021\024\n\026\035\034\027\t\b \ \024\f\035\024\032\027\036\027\017\005. \224\036\n \027\036 )Tj 0.062 Tw T* (\n\036\027\036\036, \r)Tj /Span<>> BDC ( )Tj EMC [(\030\026\002\024\021\026\b Dong, Hamad)42.1(a \017)]TJ /Span<>> BDC ( )Tj EMC [(L)35(er)-32(oy \007\035\017\021\036\035\034\027\024\f\021\034 )]TJ 0.14 Tw T* (\024\023\036\030\026\006\017\017 \002\t\035\026 \002\024\035\034\001\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016, \021\024 \036\ \f\021\034 )Tj 0.337 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \021\030\026\007\017\006\017\ \024\027\027\024\005 \r\027\031\021\030\017\002\030\033\001\027\024\005 \ )Tj 0.127 Tw T* [(\022\024\035\024\f\021\024\n\t. )0.5(\210\002\255\016\f\027\017\021\034 )0.5(\220\021\024 \n\024\032\027\024 )0.5(\021\024\035\034\022\024 \r)]TJ /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 )Tj 0.449 Tw T* (\022\024\f\r\036\027\027\024\020\024 \023\030\017\027\026\022\026 \027\036\ \024\007\027\024\030\024\007\027\024\f\021\017 \f\030\026\r\027\017\r\026\ \036)Tj 0 Tw (-)Tj 0.215 Tw T* (\n\t\b \020\030\031\023\023, \021\026\022 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \f\035\031\004\026\036 \235\024\030\n\017\030\024\r\026\ \027\017\036 )Tj 0.458 Tw T* [(\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\024\ \020\024 )0.6(\022\026\027\026\035\026, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 15.402 0 Td (\007\024\023\024\035\027\017\021\036\035\034\027\026\016 )Tj 0.267 Tw -15.402 -1.218 Td (\n\024\002\017\035\017\026\006\017\016 \022\017\001\022\017 \031\r\036\035\ \017\004\017\r\026\033\021 \r\030\036\n\016 \024\023\036\030\026\006\017\ \017, )Tj 0.021 Tw T* (\024\f\024\002\036\027\027\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\017\f\006\036\030\026\035\034\027\t\n \021\017\023\024\n \024\032\017\ \030\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\027\017\016. \225\035\036\007\024\r\026\021\036\035\034\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \f\024\022\030\026\ \013\036\027\017\036 )Tj 0.243 Tw T* (\r\030\036\n\036\027\017 \024\023\036\030\026\006\017\017 \023\030\024\017\ \024\001\035\024 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \f\024\022\030\026\013\036\027\017\016 )Tj -0.022 Tw T* (\r\030\036\n\036\027\017 \024\f\027\024\r\027\024\020\024 \220\021\026\023\ \026, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \002\030\033\001\027\024-\023\030\024\n\036\032)Tj 0 Tw (-)Tj 0.059 Tw T* (\027\024\f\021\027\024\005 \220\022\f\021\017\030\023\026\006\017\017, \004\ \021\024 \f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024\n\024)Tj 0 Tw (-)Tj T* (\020\036\027\027\024\f\021\017 \f\030\026\r\027\017\r\026\036\n\t\b \020\ \030\031\023\023.)Tj 0.182 Tw T* (\003\027\026\004\017\021\036\035\034\027\024 \002\024\035\034\001\036 \030\ \026\002\024\021, \r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026)Tj 0 Tw (-)Tj 0.137 Tw T* (\035\017, \023\024\f\r\016\013\036\027\024 \023\030\017\n\036\027\036\027\ \017\033 \017\n\023\035\026\027\021\024\r \007\035\016 \023\030\024\235\017\ )Tj 0 Tw (-)Tj 0.26 Tw T* (\035\026\022\021\017\022\017 \030\026\r\017\021\017\016 \023\026\030\026\ \f\021\024\n\026\035\034\027\t\b \020\030\t\032. \003\026)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 )Tj 0.232 Tw T* (\017\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\f\022\026 \030\036\001\036\027\017\005 \007\026\027\027\024\ \005 \023\030\024\002\035\036\n\t \017\f)Tj 0 Tw (-)Tj -0.01 Tw T* (\023\024\035\034\024\r\026\035\017\f\034 \f\017\027\021\036\021\017\004\ \036\f\022\017\036, \024\030\020\026\027\017\004\036\f\022\017\036, \030\ \026\f\f\026\f\t)Tj 0 Tw (-)Tj 0.141 Tw T* (\r\026\033\013\017\036\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \030\026\f\f\026\f\t\r\026\033\013\017\036\f\016 \017\n\023\035\ \026\027\021\t, \021\026\022 \032\036 )Tj 0.111 Tw T* (\n\036\027\016\035\024\f\034 \017\b \023\024\035\024\032\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\016\b \023\036\030\036\007\027\036\005 \002\030\033\001\027\024\ \005 )Tj 0.1 Tw T* [(\f\021\036\027\022\017. )0.6(\207\024\035\034\001\026\016 )0.5(\004\026\f\021\034 )0.6(\026\r\021\024\030\024\r )0.5(\017\f\023\024\035\034\031\036\021 )0.6(\030\026\f\023\024\035\024)]TJ 0 Tw (-)Tj 0.125 Tw T* (\032\036\027\017\036 \f\036\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\030\026\027\f\021\r\036 \n\036\032\007\031 \023\030\016\ \n\024\005 \n\t\001\006\036\005 )Tj 0.204 Tw T* (\032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\017\n \035\017\f\021\022\024\n \r\035\026\020\026\035\017\013\ \026 \023\030\016\n\024\005 \n\t\001)Tj 0 Tw (-)Tj 0.26 Tw T* (\006\t \032\017\r\024\021\026 [20\22622, 25\22627,31,33]. \212\030\031\020\ \017\036 \r\026\030\017\026\027\021\t )Tj 0.275 Tw T* (\030\026\f\023\024\035\024\032\036\027\017\016 \017\n\023\035\026\027\021\ \026: \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\036 \n\036\032\007\031 \002\030\033\001\017\027\024\005 )Tj 0.299 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \n\t\001\006\036\005 \032\017\r\024\021\026 [19,2\ 4,29,32] \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017)Tj 0 Tw (-)Tj 0.262 Tw T* (\002\030\033\001\027\024\036 \030\026\f\023\024\035\024\032\036\027\017\036\ \017\n\023\035\026\027\021\026 [23,28]. \231\026\f\021\024\021\026 )Tj 0.151 Tw T* (\030\026\r\017\021\017\016 \023\026\030\026\f\021\024\n\026\035\034\027\ \t\b \020\030\t\032 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \007\024\f\021\024\r\036\030)Tj 0 Tw (-)Tj 0.517 Tw T* (\027\024 \f\027\017\032\026\036\021\f\016, \004\021\024 \023\024\007\021\ \r\036\030\032\007\026\036\021\f\016 \030\036\031\035\034\021\026\021\026\ \n\017 )Tj 0.11 Tw T* (\n\036\021\026\026\027\026\035\017\026 $)Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.11 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001$. \225\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\ \021\024 \007\035\016 )Tj 0.112 Tw 23.244 64.543 Td (\001\017\030\024\022\024\020\024 \r\027\036\007\030\036\027\017\016 \n\036\ \021\024\007\026 \027\036\024\002\b\024\007\017\n \002\024\035\036\036 \f\ \021\026\027)Tj 0 Tw (-)Tj 0.291 Tw 0 -1.218 TD [(\007\026\030\021\017\017\030\024\r\026\027\027\t\005 )0.5(\023\024\007\b\024\007, \004\021\024 \021\030\036\002\031\036\021 \007\026\ \035\034\027\036\005\001\017\b )]TJ 0.46 Tw 0 -1.218 TD [(\017\f\f\035\036\007\024\r\026\027\017\005. )0.5(\203\036\007\024\f\021\026\021\022\024\n \n\036\021\024\007\026, )0.5(\023\024\n\017\n\024 \030\026)]TJ 0 Tw (-)Tj 0.101 Tw 0 -1.218 TD (\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\022\036 \024\023\036\030\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\036\030\017\026\035\024\r \017\n\023\035\026\027\021\024\r, )Tj 0.036 Tw 0 -1.218 TD (\016\r\035\016\036\021\f\016 \235\026\022\021 \021\036\f\027\024\020\024\ \022\024\027\021\026\022\021\026 \017\n\023\035\026\027\021\026 \f\024 \ \f\021\036\027\022\024\005 )Tj 0.395 Tw 0 -1.218 TD (\022\017\001\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\017 \002\036\031\023\030\036\004\027\024\ \r\t\023\024\035\027\036\027\027\024\005 )Tj 0.136 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\017 \220\021\024 \027\036 \023\030\017\r\024\ \007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\n \023\024\f\035\036\024\023\036\030\026\006\017)Tj 0 Tw (-)Tj 0.161 Tw 0 -1.218 TD (\024\027\027\t\n \024\f\035\024\032\027\036\027\017\016\n \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \017\255\016\r\035\036\027\017\016, \023\036\030\235\024\ \030\026)Tj 0 Tw (-)Tj 0.107 Tw T* (\006\017\005, \f\r\017\013\036\005. \215\030\024\002\035\036\n\t \r\024\ \027\017\022\026\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \023\024\007\027\017\036 )Tj 0.031 Tw T* (\f\030\024\022\017, \004\036\030\036 2 \020\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036: \220\021\024 \027\026\030\031\001\036\027\017\036 \ \235\031\027\022\006\017\017 )Tj 0.081 Tw T* (\022\017\001\022\017, \027\036\f\031\013\036\005 \f\021\024\n\031, \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\r\t\036 \024\013\031\013\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026)Tj 0 Tw (-)Tj -0.008 Tw T* [(\f\021\017 )0.5(\f\021\024\n\t. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 5.354 0 Td [(\002\024\035\034\001\017\027\f\021\r\036 )0.6(\032\036 )0.5(\r\022\035\033\004\036\027\027\t\b )0.6(\030\026\002\024\021 )0.5(\f\030\024\022 )]TJ 0.003 Tw -5.354 -1.218 Td (\027\026\002\035\033\007\036\027\017\016 \026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \027\036 \023\030\036\r\t\001\026\ \036\021, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, )Tj 0.152 Tw T* (1)Tj /Span<>> BDC ( )Tj EMC (\020\024\007. \224\026\022\032\036, \022)Tj /Span<>> BDC ( )Tj EMC (\f\024\032\026\035\036\027\017\033, \027\036\021 \007\026\027\027\t\b \024\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\026\b )Tj 0.1 Tw T* [(\235\024\030\n\017\030\024\r\026\027\017\016 )0.5(\023\026\030\026\f\021\024\n\026\035\034\027\t\b \020\030\t\032 \023\030\ \017)]TJ /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024)Tj 0 Tw (-)Tj 0.145 Tw T* (\r\026\027\017\017 \017\n\023\035\026\027\021\024\r, \004\021\024 \002\t\ \035\024 \002\t \022\030\026\005\027\036 \023\030\024\007\031\022\021\017\ \r\027\024 )Tj 0 Tw T* (\007\035\016 \007\026\035\034\027\036\005\001\036\020\024 \027\026\031\004\ \027\024\020\024 \023\024\017\f\022\026.)Tj 0.189 Tw T* (\205\024\030\n\017\030\024\r\026\027\017\036 \r\027\031\021\030\017\002\030\ \033\001\027\024\005 \f\021\024\n\t \023\026\030\026\030\036\022\021\026\ \035\034)Tj 0 Tw (-)Tj 0.034 Tw T* (\027\t\n \017\035\017 \021\030\026\027\f\030\036\022\021\026\035\034\027\ \t\n \007\024\f\021\031\023\024\n \027\036 \r\035\017\016\036\021 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.372 Tw T* (\f\021\024\021\031 \030\026\r\017\021\017\016 \023\026\030\026\f\021\024\ \n\026\035\034\027\024\005 \020\030\t\032\017 [42,45,47]. )Tj 0.272 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016 \023\030\036\007\f\021\026\r\035\016\036\ \021 \017\027\021\036\030\036\f)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\f\022\024\035\034\022\024 )Tj 0.431 Tw T* [(\n\024\032\036\021 \002\t\021\034 \220\235\235\036\022\021\017\r\036\027\ )0.5(\021\030\026\027\f\030\036\022\021\026\035\034\027\t\005 \007\024\f\021\031\ \023 )]TJ 0.158 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.911 0 Td [(\017\f\023\024\035\034\024\r\026\027\017\017 )0.5(\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\024\ \020\024 )0.6(\f\023\024\f\024\002\026 )]TJ 0 Tw -1.911 -1.218 Td (\235\024\030\n\017\030\024\r\026\027\017\016 \f\021\024\n\026\035\034\027\ \024\020\024 \022\026\027\026\035\026.)Tj 0.27 Tw T* [(\225\035\036\007\031\036\021 )0.5(\024\002\030\026\021\017\021\034 )0.6(\r\027\017\n\026\027\017\036, )0.6(\004\021\024 )0.5(\r\f\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )]TJ 0.158 Tw T* (\024\002\255\036\007\017\027\016\036\021 \024\002\013\036\036 \024\021\027\ \024\001\036\027\017\036 \022)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\033 \023\024)Tj 0 Tw (-)Tj -0.039 Tw T* (\f\021\024\016\027\027\024\005 \022\024\027\006\036\r\024\005 \022\024\035\ \024\f\021\024\n\t \022\026\022 \022)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\024\n\031 \030\036\022\024\027)Tj 0 Tw (-)Tj 0.235 Tw T* (\f\021\030\031\022\021\017\r\027\024\n\031 \220\021\026\023\031 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\ \f\021\r\026, )Tj 0.015 Tw T* (\r\024 \n\027\024\020\024\n \024\023\030\036\007\036\035\016\033\013\036\ \n \022\026\004\036\f\021\r\024 \032\017\027\017 \023\026\006\017\036\027\ \021\024\r )Tj 0.143 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\017\036 \020\024\007\t, \026)Tj /Span<>> BDC ( )Tj EMC (\027\036 \021\024\035\034\022\024 \022\024\027\006\036\027\021\030\026\006\ \017\036\005 \r\027\017\n\026)Tj 0 Tw (-)Tj 0.247 Tw T* (\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021 \035\036\004\036\027\017\016 \024\f\027\ \024\r\027\024\020\024 \026\002\024\035\036\r\026\027\017\016. )Tj 0.129 Tw T* (\203\036\024\002\b\024\007\017\n\026 \021\026\022\032\036 \030\036\r\017\ \017\016 \023\024\007\b\024\007\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026)Tj 0 Tw (-)Tj 0.207 Tw T* (\027\017\033 \023\024\f\021\024\016\027\027\024\005 \022\024\035\024\f\021\ \024\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\017 \030\036\027\017\016 \022\035\017\027\017)Tj 0 Tw (-)Tj 0.217 Tw T* [(\004\036\f\022\024\005 )0.5(\026\027\026\021\024\n\017\017 )0.6(\023\036\030\036\007\027\036\005 )0.5(\002\030\033\001\027\024\005 )0.6(\f\021\036\027\022\017, )0.5(\023\030\036\007)]TJ 0 Tw (-)Tj -0.001 Tw T* (\f\021\026\r\035\016\033\013\036\005 \f\024\002\024\005 \f\035\024\032\027\ \031\033 \f\036\020\n\036\027\021\026\030\027\031\033 \f\021\030\031\022\ \021\031\030\031, )Tj 0.204 Tw T* (\004\021\024 \002\t\035\024 \016\030\022\024 \023\030\024\007\036\n\024\027\ \f\021\030\017\030\024\r\026\027\024 \f\024\r\030\036\n\036\027\027\t\n\017\ )Tj 0.021 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \020\036\030\027\017\024\035\024\020\017\017.\ \224\026\022\024\036 \017\n\036)Tj 0 Tw (-)Tj 0.013 Tw T* (\027\036\027\017\036 \023\026\030\026\007\017\020\n\t \027\036\f\024\n\027\ \036\027\027\024 \023\030\017\002\035\017\017\021 \027\026\f \022)Tj /Span<>> BDC ( )Tj EMC (\030\036\001\036)Tj 0 Tw (-)Tj T* (\027\017\033 \007\026\027\027\024\005 \023\030\024\002\035\036\n\t.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 225.5318 Tm [(\020)21(\026\027\r\237\224\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.026 Tw 10 0 0 10 303.3071 201.1758 Tm (\237\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\t\ \005 \f\023\024\f\024\002 \235\024\030\n\017\030\024\r\026\027\017\016 \023\ \024\f\021\024)Tj 0 Tw (-)Tj 0.137 Tw T* (\016\027\027\t\b \022\017\001\036\004\027\t\b \f\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036 \017\n\023\035\026\027\021\024\r \ \007\024)Tj 0 Tw (-)Tj -0.012 Tw T* (\f\021\024\r\036\030\027\024 \f\027\017\032\026\036\021 \030\017\f\022 \024\ \002\030\026\024\r\026\027\017\016 \023\026\030\026\f\021\024\n\026\035\ \034\027\t\b )Tj 0 Tw 0 -1.218 TD (\020\030\t\032.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\226\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.8(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw [( \210)2.2(\016)-10.9(\033)-4.6(\020)-2.3(\032\004)-6.7(\034\036)]TJ /Span<>> BDC 19.334 0 Td ( )Tj EMC [(\002)-12.1(.)18.5(\215)14.3(.)]TJ /T1_0 1 Tf 0 Tc 0.75 Tw -19.334 -1.218 Td [(\225)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.2(\026)-11.8(\021)-9.8(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_1 1 Tf -0.01 Tc 0.76 Tw [( \214)6.7(\022)-12.3(\027)1.6(\007)1.3(\021\034\036)]TJ /Span<>> BDC 19.201 0 Td ( )Tj EMC [(\225)16.7(.)33.7(\002)-12.1(.)-2.2(,)-10( )]TJ -0.001 Tc 0.001 Tw -19.201 -1.218 Td [(\213)18.9(\025)0.5(\005)-4.8(\023)22.8(\027)8(\037\016)5.6(\036)1.1(\037)]TJ /Span<>> BDC 4.247 0 Td ( )Tj EMC [(\222)27.8(.)42.7(\002)-3.1(.)]TJ /T1_0 1 Tf 0.018 Tc 1.695 Tw -4.247 -1.218 Td [(\225)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_1 1 Tf -0.01 Tc 1.723 Tw 13.062 0 Td [( \214)6.6(\022)-12.2(\027)1.6(\007)1.3(\021\034\036)]TJ /Span<>> BDC 5.176 0 Td ( )Tj EMC [(\225)16.6(.)33.7(\002)-12(.)-2.2(,)-10( )]TJ 0.01 Tw -18.238 -1.218 Td [(\210)2.2(\016)-10.9(\033)-4.6(\020)-2.3(\032\004)-6.7(\034\036)]TJ /Span<>> BDC 4.233 0 Td ( )Tj EMC [(\002)-12.1(.)18.5(\215)14.4(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\204\021\032)50(\006\006\202\006)-21(\035\030\231)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (100)Tj ET endstream endobj 597 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 332.0332 42.7216 Tm [(Does th)11.1(e\022par)21(astomal h)11(ernia r)21(ate depend on th)11(e\022meth)11(od )]TJ 2.996 -1 Td [(of\022stoma formation? $meta-analy)10(sis and r)31(e)11(vie)11(w$)]TJ -41.598 1 Td [(\231\005\016\b\205\b\026 \013\b \017\005\001\016\b\026\b\f \223\005\017\005\ \205)-10(\026)11(\025\024\005\013\n\t\025\255 )]TJ 0 -1 TD [(\020\017\240\235\b \025\026\022\205\223\025\205\025\210\005 \211\025\017\ \024\b\017\025\016\005\t\b \205)-10(\026)11(\025\024\240? )]TJ T* [($\024\f\026)11(\005\005\t\005\013\b\001\022\b\022\205\b\205)-10(\026)11(\f\024\005\026\b\213\f\205\007\b\255 \025\210\001\025\017 \013\b\026)11(\f\017\005\026)-20(\220\017\240$)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.007 Tw 10 0 0 10 42.5197 724.8299 Tm (\027\036\020\024 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,96, \212\230 0,32\2262,84, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.007 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,94; \210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,02, \212\230 )Tj 0 Tw 0 -1.218 TD (0,10\22610,58, )Tj /T1_2 1 Tf 4.804 0 Td (p)Tj /T1_1 1 Tf -0.04 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,99; \210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,42, \212\230 0,57\2263,56, )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.04 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56$.)Tj /T1_3 1 Tf 0.273 Tw -4.804 -2.436 Td (\026\016\005\006\b\n\b\013\n \002\016\211\004\004 \004\007)Tj /Span<>> BDC ( )Tj EMC (\210\n\f\007\t\211 \214\007\016\210\013\016\007\006\005\b\013\235 \006\b\ \211)Tj 0 Tw (-)Tj 0.269 Tw T* (\f\016\013\217\016\212\001\b\007\206 \020\f\007\210\r \f\016\005\b\020\016\ \n\017\f\005\201\b\r\210 \013)Tj /Span<>> BDC ( )Tj EMC (\004\005\016\005)Tj 0 Tw (-)Tj T* (\016\n\017\f\005\201\b\r\210 \t\007\020\f\211\004\005\210\013)Tj /T1_1 1 Tf 0.043 Tw 0 -1.218 TD (\215\030\017 \f\030\026\r\027\036\027\017\017 \020\030\031\023\023 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\022\036 \235\024\030\n\017\030\024\r\026\027\017\016 \ \f\021\024)Tj 0 Tw (-)Tj 0.337 Tw 0 -1.218 TD [(\n\026\035\034\027\024\020\024 \022\026\027\026\035\026 \023\026\030\026\ \030\036\022\021\026\035\034\027\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.092 Tw T* (\027\t\n \007\024\f\021\031\023\024\n $\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (17$ \027\036 \002\t\035\024 \023\024\035\031\004\036\027\024 \f\021\026\ \021\017\f\021\017)Tj 0 Tw (-)Tj 0.217 Tw T* (\004\036\f\022\017 \027\026\004\017\n\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \023\026\030\026\f\021\024\n\026\035\034\027\024\ \005 \020\030\t\032\017 )Tj 0 Tw T* ($\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,14, \212\230 0,52\2262,52, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,74$.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 566.5158 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.104 Tw 10 0 0 10 42.5197 542.1598 Tm (\215\030\024\r\036\007\036\027\027\024\036 \017\f\f\035\036\007\024\r\026\ \027\017\036 \024\002\035\026\007\026\036\021 \030\016\007\024\n \024\020\ \030\026\027\017)Tj 0 Tw (-)Tj 0.165 Tw T* (\004\036\027\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \220\021\024 \027\036\ \007\024\f\021\026\021\024\004\027\024\036 \004\017\f\035\024 )Tj 0.14 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\005, \016\r\027\024 \027\036 \f\024\ \024\021\r\036\021\f\021\r\031\033\013\036\036 \n\026\f\001\021\026\002\026\ \n )Tj 0.052 Tw T* (\023\030\024\002\035\036\n\t. \225\030\026\r\027\017\r\026\036\n\t\036 \020\ \030\031\023\023\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\n\031 \023\030\017)Tj 0 Tw (-)Tj 0.232 Tw T* (\027\026\022\031, \026)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\002\036\035\034\027\024\f\021\017 \b\017\030\031\030\020\ \017\004\036\f\022\017\b )Tj -0.032 Tw T* (\n\036\021\024\007\024\r, \027\036\024\007\027\024\030\024\007\027\t. \224\ \036\n \027\036 \n\036\027\036\036, \023\024\035\031\004\036\027\027\t\036\ \030\036)Tj 0 Tw (-)Tj T* (\031\035\034\021\026\021\t \023\024\r\024\035\016\033\021 \f\007\036\035\ \026\021\034 \030\016\007 \027\026\004\017\n\t\b \r\t\r\024\007\024\r.)Tj 0.072 Tw T* (\217\026\f\f\n\026\021\030\017\r\026\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\017\030\024\r\026\021\034 \220\235\235\036\022\021\ \017\r\027\024\f\021\034 \023\030\024)Tj 0 Tw (-)Tj 0.407 Tw T* (\235\017\035\026\022\021\017\004\036\f\022\017\b \n\036\030 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\021\r\030\026\013\036\027\017\033 \023\026\030\026\f\ \021\024)Tj 0 Tw (-)Tj 0.274 Tw T* [(\n\026\035\034\027\t\b )0.5(\020\030\t\032 \027\036\r\024\n\024\032\027\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\030\t\r\036 )0.5(\024\021 \024\f\027\024\r\027\t\b )]TJ 0.096 Tw T* [(\r\036\027\034\036\r \017\b )0.5(\023\026\021\024\020\036\027\036\026. )0.5(\210\004\036\r\017\007\027\024, \004\021\024 )0.5(\036\020\024 \022\035\033\004\036\r\t\n )]TJ 0.304 Tw 23.244 30.445 Td [(\220\035\036\n\036\027\021\024\n )0.5(\016\r\035\016\036\021\f\016 )0.5(\027\036\024\002\b\024\007\017\n\024\f\021\034 )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 )]TJ 0.268 Tw T* (\f\022\r\024\027\024\020\024 \007\036\235\036\022\021\026 \023\036\030\036\ \007\027\036\005 \002\030\033\001\027\024\005 \f\021\036\027\022\017 \007\ \035\016 )Tj 0 Tw T* (\023\030\024\r\036\007\036\027\017\016 \004\036\030\036 \027\036\020\024\ \022\017\001\022\017.)Tj 0.152 Tw T* [(\224\026\022, \024\007\027\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\n\036\021\024\007\024\r \023\030\024\235\017\035\026\022\021\017\022\017\ )0.5(\016\r\035\016\036\021\f\016 )0.5(\220\022\f)]TJ 0 Tw (-)Tj 0.172 Tw T* [(\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\t\005 )0.6(\f\023\024\f\024\002 )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 )0.6(\022\024\035\024\f\021\024)]TJ 0 Tw (-)Tj 0.166 Tw T* (\n\t, \022\024\021\024\030\t\005 \007\024\f\021\024\r\036\030\027\024 \023\ \024\r\024\035\016\036\021 \f\027\017\017\021\034 \004\026\f\021\024\021\ \031 )Tj -0.041 Tw T* (\030\026\r\017\021\017\016 \023\026\030\026\f\021\024\n\026\035\034\027\ \t\b \020\030\t\032, \004\021\024 \027\026\001\035\024 \023\024\007\021\r\ \036\030\032)Tj 0 Tw (-)Tj -0.001 Tw 0 -1.218 TD (\007\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \n\036\021\026\026\027\026\035\017\036. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD (\r\026\036\n\t\b \020\030\031\023\023\026\b \017\n\036\033\021 \n\036\f\021\ \024 \030\026\035\017\004\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\022\036 )Tj 0.392 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\016 \f\021\024\n\026\035\034\027\ \024\020\024 \022\026\027\026\035\026. \025\035\026\f\f\017\004\036\f\022\ \017\005 )Tj 0.159 Tw T* [(\n\036\021\024\007 Gol)-31(igher)]TJ /Span<>> BDC ( )Tj EMC (J. \023\030\036\007\035\024\032\017\035 \f\024\007\026\r\026\021\034 \036\ \020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007)Tj 0 Tw (-)Tj 0.129 Tw T* (\002\030\033\001\017\027\027\024\n \023\030\024\f\021\030\026\027\f\021\r\ \036, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\f\201 \032\036 \024\002\030\026\031\016 )Tj 0.046 Tw 0 -1.218 TD [(\f\022\r\024\027\024\005 \007\036\235\036\022\021 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\n\t\001\036\004\027\024-\026\023\024\027\036\r\030\024\021\017\004\036\f\ \022\024\n )0.5(\f\035\024\036 )]TJ 0.124 Tw 0 -1.218 TD (\023\036\030\036\007\027\036\005 \002\030\033\001\027\024\005 \f\021\036\ \027\022\017 \017, \022\026\022 \023\030\026\r\017\035\024, \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024)Tj 0 Tw (-)Tj 0.038 Tw 0 -1.218 TD (\035\036\036 \021\024\027\022\024\005 \036\020\024 \004\026\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\023\017\020\036\035\035\017\036\r\024\005 \035\017\027\017\017. \224\036\ \n )Tj 0.219 Tw T* (\f\026\n\t\n \007\026\027\027\t\005 \n\036\021\024\007 \027\036 \023\030\ \036\007\023\024\035\026\020\026\036\021 \035\017\022\r\017\007\026\006\017\ \033 )Tj 0.44 Tw T* [(\024\f\027\024\r\027\024\020\024 \235\026\022\021\024\030\026 \030\017\f\ \022\026 )0.5(\030\026\r\017\021\017\016 \023\026\030\026\f\021\024\n\026\035\034)]TJ 0 Tw (-)Tj 0.14 Tw T* (\027\024\005 \020\030\t\032\017. \231\026\f\021\024\021\026 \017\b \f\027\ \017\032\026\036\021\f\016, \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\005 \r\017\007\017\n\024)Tj 0 Tw (-)Tj 0.189 Tw T* (\f\021\017, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \031\r\036\035\017\004\036\027\017\016 \007\035\017\027\t\ \f\021\024\n\026\035\034\027\024\020\024 \022\026\027\026\035\026 )Tj 0.053 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\036\005 \235\017\022\f\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\005 \022\017\001\022\017, \027\036\f\031\013\036\005 \f\021\024\ \n\031, \004\021\024 )Tj 0.035 Tw T* [(\023\030\026\022\021\017\004\036\f\022\017 )0.5(\017\f\022\035\033\004\026\036\021 )0.5(\023\030\024\035\026\023\f \f\021\024\n\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\035\024\032\027\031\033 )0.5(\023\026)]TJ 0 Tw (-)Tj 0.054 Tw T* (\030\026\f\021\024\n\026\035\034\027\031\033 \020\030\t\032\031, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \017\f\021\017\027\027\t\036 \023\ \026\030\026)Tj 0 Tw (-)Tj 0.063 Tw T* [(\f\021\024\n\026\035\034\027\t\036 )0.5(\020\030\t\032\017 )0.6(\r\f\201 )0.5(\032\036 )0.5(\024\002\030\026\031\033\021\f\016, )0.6(\b\024\021\034 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.369 0 Td (\027\026\004\017)Tj 0 Tw (-)Tj 0.128 Tw -19.369 -1.218 Td (\021\036\035\034\027\024 \023\024\032\036 \017)Tj /Span<>> BDC ( )Tj EMC (\f \n\036\027\034\001\036\005 \004\026\f\021\024\021\024\005. \224\026\022\ \024\005 \r\026\030\017\026\027\021 )Tj 0.214 Tw T* (\024\023\036\030\026\006\017\017 \024\f\031\013\036\f\021\r\035\016\035\f\ \016 \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (1 \017)Tj /Span<>> BDC ( )Tj EMC (5 \017\f\f\035\036\007\024)Tj 0 Tw (-)Tj 0.272 Tw T* (\r\026\027\017\005, \017)Tj /Span<>> BDC ( )Tj EMC (\r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\005 \n\036\021\026\026\027\026\035\017 [34]. )Tj ET q 42.52 276.265 453.543 117.774 re W n q /GS0 gs 453.543294 0 0 117.8252687 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\027\017\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \017\n)Tj 0 Tw (-)Tj T* (\023\035\026\027\021\026 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,87, \212\230 1,16\2263,01, )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001$.)Tj 0.272 Tw 0 -1.218 TD (\225\031\n\n\026\030\027\026\016 \004\026\f\021\024\021\026 \030\026\027\ \027\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\b \023\024\f\035\036\024\023\036\030\026)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD (\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \017\n)Tj 0 Tw (-)Tj 0.058 Tw T* (\023\035\026\027\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\020\024 \007\024\f\021\024\r\036\030\027\024 \027\036\ \030\026\035\017\004\026\035\026\f\034 \n\036\032\007\031 )Tj 0.104 Tw T* (\f\024\002\024\005 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,20, \212\230 0,81\2261,78, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.104 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,35$ $\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (10$. )Tj -0.003 Tw T* (\215\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \030\026\027\036\r\t\b \024\f\035\024\032\027\036\027\017\ \005 )Tj -0.045 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\027\026\004\017\n\t\b )0.5(\030\026\035\017\004\017\005 )0.6(\021\026\022\032\036 )0.5(\r\t\016\r\035\036\027\024 )0.6(\027\036 )]TJ 0 Tw 0 -1.218 TD (\002\t\035\024 $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,93, \212\230 0,47\2261,82, )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,82$.)Tj -0.046 Tw 0 -1.218 TD [(\215\024 )0.5(\004\026\f\021\024\021\036 )0.5(\030\026\027\027\017\b )0.6(\023\026\030\026\f\021\024\n\026\035\034\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\020\030\031\023)]TJ 0 Tw (-)Tj -0.032 Tw 0 -1.218 TD (\023\t \021\026\022\032\036 \002\t\035\017 \f\024\023\024\f\021\026\r\017\ \n\t $\210\221)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,04, \212\230 0,39\2262,77, )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,93$ $\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (11$.)Tj 0.279 Tw T* (\215\030\017 \f\030\026\r\027\036\027\017\017 \020\030\031\023\023 \f)Tj /Span<>> BDC ( )Tj EMC (\017\n\023\035\026\027\021\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\020\024 \027\036 )Tj 0.359 Tw T* (\002\t\035\024 \023\024\035\031\004\036\027\024 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\ \005 )Tj ET q 70.866 402.368 453.543 89.368 re W n q /GS0 gs 453.543294 0 0 89.5088117 70.8661652 402.2273944 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.145 Tw 9 0 0 9 70.8662 391.5681 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \203\033\016\036\034\036\022\005\020\032\t \013\033\037\017\022\021 \034\ \025\217\016\013\034 \021\034\027\022\n\016\024\035\036\037 \f\034\024\027\ \016\034\f\016\033\037\006\022\034\020\020\032\001 \034\024\027\034\003\020\ \016\020\022\t \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\024\033\037\036\020\016\020\022\022 \013\033\023\f\f c \036\020\023\035\ \033\022)Tj 0 Tw (-)Tj 0 -1.2 TD (\025\033\026\004\020\034\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\037\025\033\026\004\022\020\020\034\t \024\035\034\b\034\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13.1(t of)]TJ /Span<>> BDC ( )Tj EMC [(postoperativ)13.1(e morbidity for e)-14.8(xtraper)-36.9(itoneal vs con)11.1(v)13(entional end colostom)11(y)]TJ ET q /GS0 gs 453.543294 0 0 97.9077587 70.8661804 261.5563526 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.028 Tw 9 0 0 9 70.8662 250.721 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \203\033\016\036\034\036\022\005\020\032\t \013\033\037\017\022\021 \017\ \034\033\b\022\033\034\036\037\020\022\030 \f\037\033\037\024\035\034\b\037\ \027\007\020\034\013\034 \037\025\024\006\016\024\024\037 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\024\033\037\036\020\016\020\022\022 \013\033\023\f\f c \036\020\023\035\ \033\022\025\033\026\004\020\034\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\037)Tj 0 Tw (-)Tj T* (\025\033\026\004\022\020\020\034\t \024\035\034\b\034\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 6)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13.1(t of)]TJ /Span<>> BDC ( )Tj EMC [(parastomal abscess rate for e)-14.7(xtraper)-36.9(itoneal vs con)11.1(v)13(entional end colostom)11(y)]TJ ET q /GS0 gs 453.543294 0 0 106.7866512 70.8661804 111.8304448 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.006 Tw 9 0 0 9 70.8662 100.9701 Tm (\022\t\217\210\b\002\220 7.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \203\033\016\036\034\036\022\005\020\032\t \013\033\037\017\022\021 \033\ \037\031\036\022\035\022\030 \f\033\034\027\037\f\024\037 \024\035\034\b\ \032 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\024\033\037\036\020\016\020\022\022 \013\033\023\f\f c \036\020\023\035\ \033\022\025\033\026\004\020\034\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\037\025\033\026\004\022\020\020\034\t \024\035\034)Tj 0 Tw (-)Tj T* (\b\034\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 7)124.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( F)12(orest plo)13(t of)]TJ /Span<>> BDC ( )Tj EMC [(stoma p)46.2(rolapse rate for e)-14.8(xtraper)-37(itoneal vs con)11.1(v)13(entional end colostom)11(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\204\021\032)50(\006\006\202\006)-21(\035\030\231)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td 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637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 648.9199 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 119.3051 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 147.6516 648.9199 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 147.6516 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 648.9199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 198.6752 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 648.9199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 283.7146 648.9199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 648.9199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 648.9199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 648.9199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 648.9199 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 637.7086 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 637.4586 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 637.4586 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 119.3051 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 147.6516 637.4586 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 147.6516 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 637.4586 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 198.6752 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 637.4586 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 283.7146 637.4586 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 637.4586 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 637.4586 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 637.4586 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 637.4586 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 626.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 625.9974 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 119.3051 625.9974 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 119.3051 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 147.6516 625.9974 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 147.6516 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.6752 625.9974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 198.6752 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 241.1949 625.9974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 283.7146 625.9974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 326.2343 625.9974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 368.7539 625.9974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 411.2736 625.9974 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 453.7933 625.9974 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 605.186 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 604.936 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 604.936 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 119.3051 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 147.6516 604.936 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 147.6516 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 604.936 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 198.6752 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 604.936 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 283.7146 604.936 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 604.936 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 604.936 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 604.936 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 604.936 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 593.7248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 593.4748 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 593.4748 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 119.3051 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 147.6516 593.4748 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 147.6516 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 593.4748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 198.6752 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 593.4748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 283.7146 593.4748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 593.4748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 593.4748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 593.4748 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 593.4748 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 582.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 582.0135 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 42.7697 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 119.3051 582.0135 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 119.3051 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 147.6516 582.0135 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 147.6516 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 582.0135 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 198.6752 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 582.0135 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 283.7146 582.0135 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 582.0135 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 368.7539 582.0135 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 582.0135 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 453.7933 582.0135 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 453.7933 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 570.8022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 570.5522 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 119.3051 570.5522 cm 0 0 m 28.346 0 l S Q q 1 0 0 1 147.6516 570.5522 cm 0 0 m 51.024 0 l S Q q 1 0 0 1 198.6752 570.5522 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 241.1949 570.5522 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 283.7146 570.5522 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 326.2343 570.5522 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 368.7539 570.5522 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 411.2736 570.5522 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 453.7933 570.5522 cm 0 0 m 42.77 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 70.7935 685.2117 Tm (\032\003\002\006)Tj 7.072 0 Td (\027\002\240)Tj 4.086 0 Td (\200\r\006\t\002\240)Tj 6.018 0 Td (\255\003\006\004\b\004)Tj 4.488 0.6 Td (\020\t\212 \t\217\217\f\r)Tj (-)Tj 0.466 -1.2 Td (\240\002\004\b\t\235)Tj 5.711 1.2 Td (\016\220\004\f\004 )Tj -0.475 -1.2 Td (\220\004\201\r\217\003\004)Tj 9.559 1.917 Td (N)Tj 9.104 0 Td (\200\002\f \214/\202)Tj -13.414 -1.434 Td (\212\004\006\004\006\r\220)Tj (-)Tj 0.489 -1.2 Td (\003\004\f\001\b\002)Tj 4.643 1.2 Td (\003\006\004\b\217\006\r\220)Tj (-)Tj 0.672 -1.2 Td (\003\004\f\001\b\002)Tj 4.826 1.2 Td (\212\004\006\004\006\r\220)Tj (-)Tj 0.489 -1.2 Td (\003\004\f\001\b\002)Tj 4.643 1.2 Td (\003\006\004\b\217\006\r\220)Tj (-)Tj 0.672 -1.2 Td (\003\004\f\001\b\002)Tj /T1_2 1 Tf -52.196 -1.433 Td (Sjodahl et al. [39])Tj 9.984 0 Td (1988)Tj 4.961 0 Td (1988)Tj 5.396 0 Td (\202\027\020\035\017\016)Tj 5.589 0 Td (\030\036\021\030\024)Tj 6.24 0 Td (5)Tj 5.065 0 Td (23)Tj 5.065 0 Td (107)Tj 5.34 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -1.433 Td (Williams et al. [40,41])Tj 9.984 0 Td (1990)Tj 3.683 0 Td (1972\2261987)Tj 6.674 0 Td (\202\027\020\035\017\016)Tj 5.544 0 Td (\023\030\024\f\023)Tj 6.285 0 Td (5)Tj 5.065 0 Td (16)Tj 5.315 0 Td (12 )Tj 5.09 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -1.433 Td (Ortiz et al. [42])Tj 9.984 0 Td (1993)Tj 5.236 0 Td (\027/\007)Tj 4.807 0 Td (\230\f\023\026\027\017\016)Tj 5.858 0 Td (\023\030\024\f\023)Tj 6.285 0 Td (5)Tj 5.065 0 Td (29)Tj 5.315 0 Td (25)Tj 5.09 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -1.433 Td (Leong et al. [43])Tj 9.984 0 Td (1994)Tj 4.961 0 Td (1994)Tj 5.396 0 Td (\202\027\020\035\017\016)Tj 5.589 0 Td (\030\036\021\030\024)Tj 6.24 0 Td (5)Tj 5.065 0 Td (42)Tj 5.065 0 Td (103)Tj 5.34 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -1.433 Td (Londono-Schimmer et )Tj 0 -1.2 TD (al. [44])Tj 9.984 1.2 Td (1994)Tj 4.961 0 Td (1994)Tj 5.396 0 Td (\202\027\020\035\017\016)Tj 5.589 0 Td (\030\036\021\030\024)Tj 6.24 0 Td (5)Tj 5.065 0 Td (31)Tj 5.315 0 Td (72)Tj 5.09 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -2.633 Td (Cingi et al. [45])Tj 9.984 0 Td (2006)Tj 3.683 0 Td (2000\2262005)Tj 6.671 0 Td (\224\031\030\006\017\016)Tj 5.547 0 Td (\023\030\024\f\023)Tj 6.285 0 Td (6)Tj 5.315 0 Td (6)Tj 5.065 0 Td (14)Tj 5.09 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -1.433 Td (Pilgrim et al. [46])Tj 9.984 0 Td (2010)Tj 3.683 0 Td (2004\2262006)Tj 5.987 0 Td (\202\r\f\021\030\026\035\017\016)Tj 6.232 0 Td (\023\030\024\f\023)Tj 6.285 0 Td (6)Tj 5.065 0 Td (10)Tj 5.315 0 Td (80)Tj 5.09 0 Td (\027/\007)Tj 5.315 0 Td (\027/\007)Tj -52.957 -1.433 Td (Hardt et al. [47])Tj 9.984 0 Td (2015)Tj 3.683 0 Td (2012\2262014)Tj 6.155 0 Td (\206\036\030\n\026\027\017\016)Tj 6.299 0 Td (\030\026\027\007)Tj 6.05 0 Td (7)Tj 5.065 0 Td (30)Tj 5.315 0 Td (30)Tj 4.593 0 Td (14/16)Tj 5.315 0 Td (19/11)Tj ET q 42.52 392.782 453.543 85.575 re W n q /GS0 gs 453.543294 0 0 85.6692898 42.5196838 392.6866672 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.054 Tw 9 0 0 9 42.5197 381.9818 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \203\033\016\036\034\036\022\005\020\032\t \013\033\037\017\022\021 \005\ \027\022\035\016\027\007\020\034\024\035\022 \034\f\016\033\037\035\022\036\ \020\034\013\034 \036\b\016\004\037\035\016\027\007\024\035\036\037 \f\033\ \022)Tj /Span<>> BDC ( )Tj EMC (\024\033\037\036\020\016\020\022\022 \013\033\023\f\f c \036\020\023\035\ \033\022\025\033\026\004\020\034\t )Tj 0 Tw 0 -1.2 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\031\037\025\033\026\004\022\020\020\034\t \024\035\034\b\034\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( F)12(orest plo)13.1(t of)]TJ /Span<>> BDC ( )Tj EMC [(operation time for e)-14.8(xtraper)-36.9(itoneal vs con)11.1(v)13(entional end colostom)11(y)]TJ ET q 42.52 234.212 453.543 115.665 re W n q /GS0 gs 453.543294 0 0 115.6655385 42.5196838 234.2122692 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.027 Tw 9 0 0 9 42.5197 223.3269 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \203\033\016\036\034\036\022\005\020\032\t )0.5(\013\033\037\017\022\021 )0.5(\033\037\031\036\022\035\022\030 )0.5(\f\037\033\037\024\035\034\b\037\027\007\020\034\t )0.5(\013\033\032\003\022 )0.5(\f\033\022)]TJ /Span<>> BDC ( )Tj EMC [(\024\033\037\036\020\016\020\022\022 \013\033\023\f\f )0.5(c \036\020\023\035\033\022\025\033\026\004\020\034\t \022)]TJ /Span<>> BDC ( )Tj EMC 45.866 0 Td (\031\037\025\033\026\004\022\020)Tj 0 Tw (-)Tj -45.866 -1.2 Td (\020\034\t \024\035\034\b\034\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( F)12(orest plo)13.1(t of)]TJ /Span<>> BDC ( )Tj EMC [(parastomal her)-13.8(nia incidence for e)-14.9(xtraper)-36.9(itoneal vs con)11(v)13(entional end colostom)11(y)]TJ ET q /GS0 gs 453.543294 0 0 79.4300711 42.5196838 111.7928751 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.032 Tw 9 0 0 9 42.5197 100.9701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \203\033\016\036\034\036\022\005\020\032\t \013\033\037\017\022\021 \f\034\ \024\027\016\034\f\016\033\037\006\022\034\020\020\034\013\034 \021\034\t\ \021\034-\005\020\030 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\024\033\037\036\020\016\020\022\022 \013\033\023\f\f c \036\020\023\035\ \033\022\025\033\026\004\020\034\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\037\025\033\026\004\022\020\020\034\t )Tj 0 Tw T* (\024\035\034\b\034\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( F)12(orest plo)13.1(t of)]TJ /Span<>> BDC ( )Tj EMC [(hospital stay for e)-14.8(xtraper)-36.9(itoneal vs con)11.1(v)13(entional end colostom)11.1(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\204\021\032)50(\006\006\202\006)-21(\035\030\231)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 512.7895 56.0378 Tm (95)Tj ET endstream endobj 622 0 obj <>stream ÿØÿîAdobedÿÛ '$''''$25552;;;;;;;;;; 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Anal sphinc)-16(ter r)-24(econstr)-21.9(uc)]TJ 0 Tw (-)Tj 0.193 Tw -1.296 -1.25 Td [(t)-32(ion wi)-23.9(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(gl)35(uteus maximus muscle: ana)15(t)17(omic and phy)-13(siol)30(o)-16(gic )]TJ 0.119 Tw T* [(consider)-33(a)15.1(t)-32(ions concer)-15(ning convent)-32(ional and d)17(ynamic gl)35(uteopl)-15.9(ast)-10(y. )]TJ /T1_2 1 Tf 0.153 Tw T* [(Plast R)21(econstr )0.5(Surg.)]TJ /T1_1 1 Tf [( 1996;98$2$:293\226304. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00006534-)Tj T* (199608000-00013)Tj 0 0 0 1 k /GS1 gs -0.05 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\204\026\001\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\213., \236\036\030\002\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\200.\230., \225\017\020\026\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \225\235\017\027\022\021\036\030\027\026\016 )Tj 0.01 Tw -1.796 -1.25 Td [(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\034 )0.7(\031)]TJ /Span<>> BDC ( )Tj EMC 7.801 0 Td [(\007\036\021\036\005 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 3.249 0 Td [(\026\027\024\030\036\022\021\026\035\034\027\024\005 )0.6(\023\026\021\024\035\024\020\017\036\005, )0.6(\204. )0.6(\204\210\203\230\025\230, )]TJ 0 Tw -11.05 -1.25 Td (2015.)Tj 0.172 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)40(oshiok)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(K, K)25(eighle)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(MR. Cl)-31(inical and manome)-12(tr)-37(ic assess)26(ment )]TJ 0.002 Tc 0.35 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(gr)-33.4(a)-17.4(c)-24.4(il)-31.3(is muscle tr)-33.4(anspl)-16.4(ant for fecal incont)-32.4(inence. )]TJ /T1_2 1 Tf [(Dis Colon)2( )]TJ 0 Tc 0 Tw T* [(R)21(ectum)]TJ /T1_1 1 Tf 0.023 Tw [(. 1988;31$10$:767\226769. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02560102)Tj 0 0 0 1 k /GS1 gs -0.068 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\025\024\n\017\f\f\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\202., \206\035\031\001\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \025\024\035\036\f\027\017\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\203.\206. \215\030\017\n\036\027\036\027\017\036 )Tj 0.123 Tw -1.796 -1.25 Td (\024\002\255\036\n\024\024\002\030\026\031\033\013\017\b \026\020\036\027\ \021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \026\027\026\035\034\027\024\005 \017\027\022\ \024\027\021\017\027\036\027\006\017\017. )Tj /T1_2 1 Tf 0.023 Tw T* (\203\016\035\024\021\037\030 \001\022\033\023\033\013\022\030.)Tj /T1_1 1 Tf ( 2014;18$1$:30\22634.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 469.0919 Tm (REFERENCES)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.039 Tw 8 0 0 8 70.8661 456.2572 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(hchapov)]TJ /Span<>> BDC ( )Tj EMC [(N.F., M)-24(okr)-22(ushina)]TJ /Span<>> BDC ( )Tj EMC [(O.G., V)25(a)15(t)17(ol)-31(inK.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC (ear)Tj 0 Tw 25.99 0 Td (-)Tj 0.085 Tw -27.286 -1.25 Td [(l)35(yone-st)15(a)-17(ge r)-32.9(adical cor)-24(r)-24(ec)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)30(o)-14(w for)-16(ms of)]TJ /Span<>> BDC ( )Tj EMC [(anus a)14.9(tr)-23.9(esia. )]TJ /T1_2 1 Tf 0 Tw [(V)32(op)46(rosy )]TJ 0.079 Tw T* [(Praktichesk)13.1(oi P)15(ediatr)-36.9(ii $Clinical Practice in P)15(ediatr)-36.9(ics$)]TJ /T1_1 1 Tf (. 2014;8$3$:8\226)Tj 0.023 Tw T* (14. $in Russ.$.)Tj -0.078 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(hchapov)]TJ /Span<>> BDC ( )Tj EMC [(N.F., M)-23.9(okr)-22(ushina)]TJ /Span<>> BDC ( )Tj EMC [(O.G., Gur)-24(ev)-16(ich)]TJ /Span<>> BDC ( )Tj EMC [(A.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ehabil)-31(i)-24(t)15.1(a)14.9(t)-31.9(ion )]TJ 0.272 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(young childr)-24(en af)-28(ter cor)-23.9(r)-24(ec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(anor)-24(ec)-16(t)15.1(al defec)-16(ts. )]TJ /T1_2 1 Tf 0 Tw [(R)22(ussian )]TJ 0.023 Tw T* [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(P)15(ediatr)-36.9(ic Surg)12(er)-42.9(y)]TJ /T1_1 1 Tf (. 2014;18$4$:16\22620. $in Russ.$.)Tj 0.234 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(hchapov)]TJ /Span<>> BDC ( )Tj EMC [(N.F. Dia)-17(gnost)-32(ics and tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(l)30(o)-14(w-t)-9.9(ype anor)-24(ec)]TJ 0 Tw (-)Tj 0.185 Tw -1.296 -1.25 Td [(t)15(al malfor)-15.9(ma)15(t)-32(ions in newbor)-15(n babies. )]TJ /T1_2 1 Tf [(R)22(ussian Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(P)15(ediatr)-36.9(ic )]TJ 0 Tw T* [(Surg)12(er)-43(y)]TJ /T1_1 1 Tf 0.023 Tw (. 2014;18$2$:34\22638. $in Russ.$.)Tj -0.084 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(oynov)]TJ /Span<>> BDC ( )Tj EMC [(Y)35.1(u.Y)35(u., G)20(r)-33(amzin)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Kr)-37(i)-16(vosheenko)]TJ /Span<>> BDC ( )Tj EMC [(N.V., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(eoper)-32.9(a)15(t)-32(ions )]TJ 0.041 Tw -1.296 -1.25 Td [(in childr)-24(en wi)-23.9(t)-13(h anor)-24(ec)-15.9(t)15(al malfor)-16(ma)15(t)-32(ions. )]TJ /T1_2 1 Tf [(Siber)-37(ian Scientif)-42.9(ic Medical )]TJ 0 Tw T* [(Jour)-13.9(nal)]TJ /T1_1 1 Tf -0.081 Tw [(. 2020;40$1$:67\22672. $In Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.15372/S)17(SMJ20200109)]TJ 0 0 0 1 k /GS1 gs 0.113 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Khvor)-32(ost)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC [(I.N., S)-16(hr)-33(amko)]TJ /Span<>> BDC ( )Tj EMC [(V.N., Andr)-24(eev)]TJ /Span<>> BDC ( )Tj EMC [(D.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve )]TJ -0.003 Tw -1.296 -1.25 Td [(assess)26(ment of)]TJ /Span<>> BDC ( )Tj EMC [(spinc)-16(ter muscle com)10(ple)-18(x in childr)-24(en af)-28(ter sur)-32(gical cor)]TJ 0 Tw 27.286 0 Td (-)Tj -0.02 Tw -27.286 -1.25 Td [(r)-24(ec)-16(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(anor)-23.9(ec)-16(t)15(al malfor)-16(ma)15.1(t)-32(ion. )]TJ /T1_2 1 Tf [(Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(V)32(olgog)14.1(rad S)28(tate Medical )]TJ 0 Tw T* [(U)22(niv)13(ersity)]TJ /T1_1 1 Tf 0.004 Tw [(. 2020;17$2$:95\22699. $In Russ.$. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.19163/1994-9480-)Tj T* (2020-2$74$-95-99)Tj 0 0 0 1 k /GS1 gs 0.001 Tc 0.35 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.299 0 Td [(Bischof)-56(f)]TJ /Span<>> BDC ( )Tj EMC 3.948 0 Td [(A, )0.5(L)35(ev)-16(i)-24(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC 4.287 0 Td [(MA, )0.6(P)29.9(e\361a)]TJ /Span<>> BDC ( )Tj EMC 4.51 0 Td [(A. )0.5(U)12.9(pd)42(a)15(te )0.5(on )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 8.375 0 Td [(mana)-17(gement)1( )]TJ 0 Tc 0.129 Tw -22.42 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(anor)-24(ec)-15.9(t)15(al malfor)-15.9(ma)15(t)-32(ions. )]TJ /T1_2 1 Tf [(P)15(ediatr Surg Int)]TJ /T1_1 1 Tf (. 2013;29$9$:899\226904. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00383-013-3355-z)Tj 0 0 0 1 k /GS1 gs 0.198 Tw 27.208 25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Kr)-32(ois)]TJ /Span<>> BDC ( )Tj EMC [(W, R)12.9(eck)]TJ /Span<>> BDC ( )Tj EMC [(C)20(A, Dar)-24(bar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(technique t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(econstr)-22(uc)-15.9(t )]TJ 0.023 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 1.606 0 Td [(anal )0.5(sphinc)-16(ter)-10(s )0.5(foll)30.1(o)-14(wing )0.5(ia)15(tr)-31.9(o)-16(genic )0.5(str)-23.9(e)-12(tching )0.5(r)-24(el)-15.9(a)15(ted )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 23.423 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 0.718 0 Td (pull-)Tj 0.051 Tw -25.748 -1.25 Td [(t)-13(hr)-31.9(ough for Hir)-10(schsp)25(r)-22(ung disease. )]TJ /T1_2 1 Tf [(J P)15(ediatr Surg)]TJ /T1_1 1 Tf (. 2021;56$6$:1242\226)Tj 0.023 Tw T* [(1246. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.jpedsur)-32(g.2020.12.007)]TJ 0 0 0 1 k /GS1 gs 0.312 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)10(o)-14(wer)]TJ /Span<>> BDC ( )Tj EMC [(D, F)-19(i)-23.9(tzp)32(a)15(tr)-37(ick)]TJ /Span<>> BDC ( )Tj EMC [(M, O\241Her)-29.9(l)-31(ihy)]TJ /Span<>> BDC ( )Tj EMC [(C. Obste)-11.9(tr)-37(ic anal sphinc)-16(ter )]TJ 0.039 Tw -1.296 -1.25 Td [(injur)-23.9(y: ho)-13.9(w t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(avoid, ho)-14(w t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ep)32(air: a)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-23.9(ter)-33(a)15(tur)-23.9(e r)-24(ev)-15.9(iew. )]TJ /T1_2 1 Tf [(J F)15(am Pract)]TJ /T1_1 1 Tf 0 Tw (. )Tj T* (2006;55$3$:193\226200.)Tj 0.164 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Guel)-31(inck)-23.9(x)]TJ /Span<>> BDC ( )Tj EMC [(P)35.1(J, S)-16(insel)]TJ /Span<>> BDC ( )Tj EMC [(NK, G)20(r)-22(uwez)]TJ /Span<>> BDC ( )Tj EMC [(J)15(A. Anal sphinc)-16(ter r)-24(econstr)-21.9(uc)]TJ 0 Tw (-)Tj 0.193 Tw -1.296 -1.25 Td [(t)-32(ion wi)-23.9(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(gl)35(uteus maximus muscle: ana)15(t)17(omic and phy)-13(siol)30(o)-16(gic )]TJ 0.119 Tw T* [(consider)-33(a)15.1(t)-32(ions concer)-15(ning convent)-32(ional and d)17(ynamic gl)35(uteopl)-15.9(ast)-10(y. )]TJ /T1_2 1 Tf 0.153 Tw T* [(Plast R)21(econstr )0.5(Surg)]TJ /T1_1 1 Tf [(. 1996;98$2$:293\226304. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00006534-)Tj T* (199608000-00013)Tj 0 0 0 1 k /GS1 gs 0.176 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mashkov)Tj /Span<>> BDC ( )Tj EMC [(A.E., S)-16(hcher)-24(bina)]TJ /Span<>> BDC ( )Tj EMC [(V.I., S)-16(iga)-17(chev)]TJ /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sphinc)-16(ter )]TJ -0.002 Tw -1.796 -1.25 Td [(insuf)-56(f)-27.9(ic)-24(iency in childr)-23.9(en wi)-23.9(t)-13(h anor)-23.9(ec)-16(t)15(al p)32(a)15(t)-13(hol)30(o)-16(g)16(y, \204osco)-14(w: MONIKI; )]TJ 0.023 Tw T* (2015. $in Russ.$.)Tj 0.172 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)40(oshiok)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(K, K)25(eighle)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(MR. Cl)-31(inical and manome)-12(tr)-37(ic assess)26(ment )]TJ 0.002 Tc 0.35 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(gr)-33.4(a)-17.4(c)-24.4(il)-31.3(is muscle tr)-33.4(anspl)-16.4(ant for fecal incont)-32.4(inence. )]TJ /T1_2 1 Tf [(Dis Colon)2( )]TJ 0 Tc 0 Tw T* [(R)21(ectum)]TJ /T1_1 1 Tf 0.023 Tw [(. 1988;31$10$:767\226769. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02560102)Tj 0 0 0 1 k /GS1 gs 0.113 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(omissar)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(I.A., Gl)35(ushakov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(V.A., K)25(olesnikov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(N.G. 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\r)6.6(\034)-4.1(\033)4.2(\n)0.5(\037)3.2(\013)1(\022)-1.8(\020)0.5(\037)]TJ /Span<>> BDC 4.484 0 Td ( )Tj EMC [(\222)19.8(.)34.7(\002)-11.1(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw 4.514 64.543 Td [(\025)-3.5(\030)-5.6(\017)-11.3(\021)-15.7(\017)6.5(\004)-6.2(\036)-8.4(\f\022)-4.5(\017)3.8(\005)2( \023)-6.2(\036\030)-14.2(\036)-8.4(\f)-2.1(\n)1.8(\024)-8.9(\021)-26.8(\030)2( \030)-8.8(\031)-9.3(\022)1.3(\024)-2.3(\023)4.2(\017\f)0.5(\017)15.2(:)]TJ /T1_4 1 Tf -0.076 Tc 0.076 Tw 14.48 0 Td [( \246)-65.2(\037)-74.2(\f)-71.5(\034)-66.4(\036)]TJ /Span<>> BDC 2.95 0 Td ( )Tj EMC [(\222)-47.2(.)0.5(\233)-21.3(.)]TJ /T1_1 1 Tf -0.002 Tc 0.002 Tw -17.43 -1.218 Td [(\230)-13.3(\035)-18.6(\035\033)-10.5(\f)-38(\021)-30.7(\030)-13.4(\026)-2.3(\006)-8(\017\017)11.2(:)]TJ /T1_4 1 Tf -0.076 Tc 0.076 Tw 5.975 0 Td [( \246)-65.2(\037)-74.2(\f)-71.5(\034)-66.4(\036)]TJ /Span<>> BDC 2.95 0 Td ( )Tj EMC [(\222)-47.2(.)0.5(\233)-21.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -8.925 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036 \021)-9.9(\036)-5.4(\022)-1.7(\f)-36(\021)-21.5(\026)3.7(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \r)25.4(\023)13.8(\027\022)-2.3(\021\034\036)]TJ /Span<>> BDC 13.541 0 Td ( )Tj EMC [(\203)-8.6(.)18.5(\215)14.4(.)]TJ /T1_1 1 Tf 0 Tc 0.815 Tw -13.541 -1.218 Td [(\211)-16.1(\021)-17.7(\r)-8.5(\036)-1.7(\030)-7(\032)-36(\007)-8.7(\036)-5.3(\027)1.7(\017)-8.7(\036 \024)-2.9(\022)-0.7(\024)-4.3(\027)4.5(\004\026)-11.8(\021)-9.9(\036)-29.2(\035)2.2(\034\027)-4.3(\024)-4.2(\020)-2.2(\024 \r)-8.9(\026\030)-7.6(\017)-0.6(\026\027)-13.3(\021)-21.5(\026 \f)-36(\021)-21.5(\026)-11.8(\021)-17.7(\034\017)13.3(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.076 Tc 0.076 Tw 0 -1.218 TD [(\246)-65.2(\037)-74.2(\f)-71.5(\034)-66.4(\036)]TJ /Span<>> BDC 2.717 0 Td ( )Tj EMC [(\222)-47.2(.)0.5(\233)-21.3(.)]TJ /T1_1 1 Tf 0 Tc 0.206 Tw -2.717 -1.218 Td [(\236)-19.6(\026)-1.9(\023)-3.9(\024)-4.3(\r)]TJ /Span<>> BDC ( )Tj EMC [(\203)13.2(.)55.9(\205)54.4(. \017)2.7(\n)-4.6(\036)-16.7(\036)-17.2(\021 \023)-3.9(\024)-10.9(\035)2.2(\027)1.7(\t)1.7(\005 \007)-4.4(\024)-8(\f)-36(\021)-51(\031)-11.3(\023 \022)-0.8(\024 \r)-2.7(\f)-0.8(\036)-2.6(\n \007)-20.1(\026\027)1.7(\027)1.7(\t)2.7(\n )]TJ 0.073 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.823 0 Td [(\002)-14.3(\036)-1.7(\030)-16.2(\036)-17.2(\021 )0.6(\027)-0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 3.957 0 Td [(\f)-0.8(\036)-12.3(\002\016 )0.6(\024)-10.9(\021)-17.7(\r)-8.5(\036)-17.2(\021)-2.2(\f)-36(\021)-17.7(\r)-8.5(\036)-5.4(\027)1.7(\027)-4.3(\024)-8(\f)-36(\021)-17.7(\034 )0.6()-9.9(\026)]TJ /Span<>> BDC ( )Tj EMC 10.638 0 Td [(\017)-12.8(\b )0.5(\006)-5.9(\036)-29.2(\035)-2.5(\024)-8(\f)-36(\021)-17.7(\027)-4.3(\024)-8(\f)-36(\021)-17.7(\034)-26.3(, )]TJ 0.549 Tw -15.418 -1.218 Td [(\021)-6.5(\024)-4.1(\004)2.2(\027)-4.3(\024)-8(\f)-36(\021)-17.6(\034)-26.3(, \026\027)-0.6(\026)-33.1(\035)2.2(\017)2.7( \017)]TJ /Span<>> BDC ( )Tj EMC [(\023)-3.9(\024)7(\220)-12.4(\021)-6.5(\024\n)-4.6(\031 \016)2.3(\r)-20.1(\035)-5(\016)-6.8(\036)-17.2(\021)-2.2(\f)-27.3(\016 \020)-13.3(\026\030)-11.4(\026\027)-13.3(\021)-6.5(\024\n )]TJ -0.008 Tc 0.008 Tw 0 -1.218 TD [(\f)-5.3(\024)-12.1(\007)-16.7(\036)-9.7(\030)-15(\032)-29(\026)-8.2(\027)-6.3(\017)-13.5(\016.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf -0.095 Tw 0 -1.218 TD [(T)-8(h)-5.3(e c)3.7(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf 0.001 Tc -0.096 Tw [( N)9.1(i)8.9(k)13.9(ol)4.3(a)-4.8(y)]TJ /Span<>> BDC 17.456 0 Td ( )Tj EMC [(F)66.2(.)]TJ /Span<>> BDC 0.83 0 Td ( )Tj EMC [(S)16.3(h)2.4(c)2.9(h)5.7(ap)-3.9(ov)]TJ /T1_1 1 Tf 0 Tc 1.836 Tw -18.286 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d )0.5(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.8(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 19.086 0 Td [(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)]TJ 0 Tw 2.672 0 Td (-)Tj -0.002 Tc 0.002 Tw -21.758 -1.218 Td [(a)-3.5(l)-46.6(s:)]TJ /T1_4 1 Tf 0 Tc 0.998 Tw 1.451 0 Td [( N)8(i)7.9(k)13(o)-1.1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)1.4(c)1.8(h)4.8(a)-0.8(p)-4.8(o)-0.6(v)33.6(, D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)2.8(l)4.3(i)7.9(k)12.9(o)-0.6(v)33.6(, )]TJ -0.011 Tc 0.011 Tw -1.451 -1.218 Td [(R)-15.1(is)-3.2(a)-11.1(l)-7.7(a)-15.8(t)]TJ /Span<>> BDC 2.682 0 Td ( )Tj EMC [(I)-8.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(D)1.8(z)-2.9(h)-6.2(a)-15.4(va)-15.9(t)-17.7(k)-5.7(h)-6.2(a)-11.8(n)-9.1(o)-11.6(va)]TJ /T1_1 1 Tf -0.002 Tc -0.074 Tw -3.546 -1.218 Td [(I)2.6(n)-9.5(t)-17.2(e)-4.1(r)-32.2(p)-5.7(r)-11.4(e)-14.8(t)-29.7(a)-10.4(t)-39.4(i)1.2(o)-1.2(n)-2( )0.5(an)-6.6(d)-2( )0.5(ana)-3.4(ly)-21.5(s)-18.6(i)0.7(s)-2( )0.5(o)-4.2(f)]TJ /Span<>> BDC 11.927 0 Td ( )Tj EMC 0.156 0 Td [(d)-1.3(a)-10.4(t)-29.7(a)2.2(:)]TJ /T1_4 1 Tf 0 Tc -0.076 Tw 2.105 0 Td [( )0.5(N)8(i)7.9(k)13(o)-1.1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC 3.217 0 Td [(F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC 0.848 0 Td [(S)15.3(h)1.4(c)1.8(h)4.8(a)-0.8(p)-4.9(o)-0.6(v)33.6(, )]TJ 0 Tw -18.254 -1.218 Td [(D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)2.8(l)4.3(i)7.9(k)12.9(o)-0.6(v)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g t)-16.7(h)-5.3(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_4 1 Tf 0.001 Tc -0.001 Tw [( N)9.1(i)8.9(k)13.9(ol)4.4(a)-4.9(y)]TJ /Span<>> BDC 10 0 Td ( )Tj EMC [(F)66.2(.)]TJ /Span<>> BDC 0.925 0 Td ( )Tj EMC [(S)16.3(h)2.4(c)2.9(h)5.8(ap)-3.9(ov)]TJ /T1_1 1 Tf 0 Tc 0.005 Tw -10.925 -1.218 Td [(C)-6.5(o)0.8(n)-4.6(d)1.2(u)3.7(c)-32.5(t)-37.4(i)7.1(n)-1.9(g a)2.4(n)]TJ /Span<>> BDC ( )Tj EMC [(u)1.7(l)-5.5(t)-21.4(r)-21.5(a)-17.1(s)-9.4(o)-3.4(u)5.2(n)-4.6(d e)-23.9(x)-14.7(am)-4.6(i)7.1(n)2.2(a)-8.4(t)-37.4(i)3.2(o)0.8(n)-18.5(, i)7.1(n)-7.5(t)-15.2(e)-2.1(r)-30.2(p)-3.8(r)-9.4(e)-12.7(t)-27.7(a)-8.4(t)-37.4(i)3.2(o)0.8(n )]TJ -0.002 Tc 0.002 Tw T* [(an)-6.6(d)-2( ana)-3.5(ly)-21.6(s)-18.5(i)0.7(s)-2( o)-4.2(f)]TJ /Span<>> BDC 6.002 0 Td ( )Tj EMC [(d)-1.3(a)-10.4(t)-29.7(a)2.2(:)]TJ /T1_4 1 Tf -0.011 Tc 0.011 Tw 2.338 0 Td [( R)-15.1(is)-3.2(a)-11.1(l)-7.6(a)-15.9(t)]TJ /Span<>> BDC 2.915 0 Td ( )Tj EMC [(I)-8.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(D)1.8(z)-2.9(h)-6.2(a)-15.4(va)-15.9(t)-17.7(k)-5.7(h)-6.2(a)-11.8(n)-9.1(o)-11.6(va)]TJ /T1_1 1 Tf 0 Tc 0.087 Tw -12.119 -1.218 Td [(A)-2.6(n)2.2(a)-1.5(l)1.7(y)-19.5(s)-16.6(i)2.8(s )0.5(a)2.3(n)-4.6(d )0.5(i)7.1(n)-7.5(t)-15.2(e)-2.1(r)-30.1(p)-3.8(r)-9.4(e)-12.8(t)-27.7(a)-8.4(t)-37.4(i)3.2(o)0.8(n )0.5(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 12.734 0 Td [(t)-16.7(h)-5.3(e )0.5(d)0.7(a)-8.4(t)-27.7(a )0.5(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 4.949 0 Td [(t)-16.7(h)-5.3(e )0.5(p)-10.4(a)-8.4(t)-16.7(h)-0.9(o)]TJ 0 Tw 4.075 0 Td (-)Tj 0.002 Tc -0.002 Tw -21.758 -1.218 Td [(l)-9.3(o)-6.9(g)-17.5(i)7.2(c)-9.8(a)0.5(l)2( a)4.4(n)-2.5(d)1.9( mor)-28.2(p)-4.1(h)1.1(o)-3.8(l)-9.3(o)-6.9(g)-17.5(i)7.2(c)-9.8(a)0.5(l)2( s)-18(t)-10.8(u)1.5(d)-8.9(y)-9.8(:)]TJ /T1_4 1 Tf -0.002 Tc 0.002 Tw 13.333 0 Td [( N)6.7(a)-6.9(ta)-2.1(l)2.3(i)3.9(a)]TJ /Span<>> BDC 3.079 0 Td ( )Tj EMC (S.)Tj /Span<>> BDC 0.99 0 Td ( )Tj EMC [(K)11.3(o)-0.7(r)0.8(ch)2.8(a)-2.8(g)-16.5(i)6.4(n)2.8(a)]TJ /T1_1 1 Tf 0 Tc -0.012 Tw -17.401 -1.218 Td [(C)-5.6(r)-48(i)-6(t)-37.4(i)5.2(c)-11.8(a)-1.4(l r)-9.4(e)-6(v)-43.2(i)2.7(s)-16.6(i)3.2(o)0.8(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e m)1.8(a)2.4(n)2.5(u)-12.2(s)-7.9(c)-12.8(r)-48(i)7.6(p)-12.3(t)-20.1(:)]TJ /T1_4 1 Tf 0.001 Tc -0.013 Tw [( N)9(i)8.9(k)13.9(ol)4.3(a)-4.9(y)]TJ /Span<>> BDC 17.291 0 Td ( )Tj EMC [(F)66.2(.)]TJ /Span<>> BDC 0.912 0 Td ( )Tj EMC [(S)16.3(h)2.4(c)2.8(h)5.8(ap)-3.9(ov)]TJ /T1_1 1 Tf -0.001 Tw -18.204 -1.218 Td [(Il)-18(l)-12.6(u)-11.3(s)-19(t)-20.4(r)-20.5(a)-7.4(t)-36.4(i)4.3(o)1.8(ns)3.2(:)]TJ /T1_4 1 Tf 5.414 0 Td [( N)9(i)9(k)13.9(ol)4.3(a)-4.9(y)]TJ /Span<>> BDC 3.137 0 Td ( )Tj EMC [(F)66.2(.)]TJ /Span<>> BDC 0.925 0 Td ( )Tj EMC [(S)16.3(h)2.4(c)2.9(h)5.8(ap)-3.9(ov)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -9.475 -1.218 Td [(T)58.3(e)-17.9(x)-30(t)6( e)-5.3(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 5.203 0 Td [( D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.3(u)2.8(l)4.3(i)7.9(k)12.9(ov)]TJ /T1_1 1 Tf 0.694 Tw -5.203 -1.218 Td [(A)-1.2(p)-2.4(p)-3.8(r)-6(ov)-19.1(a)-1.5(l o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e \251)6.2(n)2.2(a)-1.5(l v)-8.9(e)-2.1(r)-21(s)-16.6(i)3.2(o)0.8(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e ar)-51.4(t)-37.4(i)5.2(c)-4.5(l)-14.3(e)7(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0.001 Tc -0.001 Tw T* [(N)9(i)8.9(k)14(ol)4.3(a)-4.9(y)]TJ /Span<>> BDC 2.904 0 Td ( )Tj EMC [(F)66.2(.)]TJ /Span<>> BDC 0.925 0 Td ( )Tj EMC [(S)16.3(h)2.4(c)2.8(h)5.9(ap)-3.9(ov)]TJ /T1_1 1 Tf 0 Tc 0.08 Tw -3.829 -1.218 Td [(Shch)1.8(a)1.3(p)-12.7(ov)]TJ /Span<>> BDC ( )Tj EMC 4.17 0 Td [(N)7.5(.)10.9(F)81(. )0.5(h)1.8(a)-17.1(s )0.5(f)-27.7(u)1.6(l)-19(l )0.5(a)-1.2(c)4.1(ce)-13.3(s)-12.8(s )0.5(t)-12.3(o)]TJ /Span<>> BDC ( )Tj EMC 9.322 0 Td [(a)-1.5(l)-19(l )0.5(d)0.7(a)-8.4(t)-27.7(a )0.5(a)2.4(n)-4.6(d )0.5(a)-17.1(s)-12.8(s)1.2(u)3.2(m)-6.8(e)-13.3(s )]TJ -0.043 Tw -13.492 -1.218 Td [(r)-9.4(e)-13.3(s)0.8(p)-12.7(o)0.8(n)-1.2(s)-16.6(i)4.2(b)-9.9(i)3(l)-7(i)-6(t)-42.2(y )0.5(f)-15.6(o)-1.9(r )0.6(t)-16.7(h)-5.3(e)-9.4(i)4.1(r )0.5(i)7.1(n)-7.5(t)-15.2(e)-11.3(g)-3.6(r)-47.9(i)-6(t)-42.2(y)4.1(, )0.5(a)-1.2(c)4.1(c)-2.1(u)2.4(r)-21.5(a)-1.2(c)-33.4(y)4.1(, )0.5(a)2.4(n)2.2(a)-1.5(l)1.7(y)-19.5(s)-16.6(i)2.7(s )0.6(a)2.4(n)-4.6(d )]TJ 0 Tw T* [(t)-16.7(h)-5.3(e)-2.1(r)-9.4(e)-8.9(f)-15.6(o)-1.9(r)-9.3(e i)2.7(s t)-16.7(h)-5.3(e)]TJ /Span<>> BDC ( )Tj EMC [(g)0.5(u)3.6(ar)-21.5(a)2.4(n)-7.5(t)-12.3(o)-1.9(r o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e c)3.8(o)0.8(n)-7.5(t)-15.2(e)-1.6(n)-7.5(t)-20.1(.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\255\026\036\031\036\025\034\222 \017\225 \032\026\020\017\022\032\233 $\ ORCID$)Tj /T1_1 1 Tf 0.574 Tw 0 -1.218 TD (\236\026\023\024\r \203\017\022\024\035\026\005 \205\036\007\024\030\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\036\007\031\013\017\005 )Tj 0.541 Tw T* (\007\036\021\f\022\017\005 \b\017\030\031\030\020 \007\036\021\f\022\024\ \005 \f\035\031\032\002\t \021\024\030\026\022\024-\026\002\007\024\n\017\ )Tj 0 Tw (-)Tj 0.81 Tw T* [(\027\026\035\034\027\024\005 \b\017\030\031\030\020\017\017 )0.5(\202\210 \253\230\035\034\017\027\f\022\026\016 )0.5(\002\024\035\034\027\017\006\026\273; )]TJ 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0002-0036-0546)Tj 0.509 Tw T* (\212\032\026\r\026\021\b\026\027\024\r\026 \217\017\f\026\035\026\021 \230\ \f\026\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\f\f\017)Tj 0 Tw (-)Tj 0.244 Tw T* [(\f\021\036\027\021 )0.5(\022\026\235\036\007\030\t )0.6(\035\031\004\036\r\024\005 )0.5(\007\017\026\020\027\024\f\021\017\022\017 )0.5(\007\036\021\f\022\024\020\024 )0.6(\r\024)]TJ 0 Tw (-)Tj 0.133 Tw T* (\030\026\f\021\026 \205\206\207\210\211 \212\215\210 \217\204\202\203\215\ \210 \217\205, \r\030\026\004 \031\035\034\021\030\026\r\031\022\024\r\024\ \005 )Tj 0.08 Tw T* (\007\017\026\020\027\024\f\021\017\022\017, \206\207\211\003 \253\212\206\ \025\207 \017\n. \203.\205. \205\017\035\026\021\024\r\026\273 \212\003\204\ \020. )Tj 0 Tw T* (\204\024\f\022\r\t; ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-4504-8414)Tj -0.173 Tw T* (\025\024\030\004\026\020\017\027\026 \203\026\021\026\035\034\016 \225\036\ \030\020\036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\023\026\021\024\035\024\020\024\026\027\026\021\024\ \n, )Tj 0.074 Tw T* [(\206\207\211\003 )0.5(\253\212\206\025\207 \017\n. )0.5(\203.\205. )0.5(\205\017\035\026\021\024\r\026\273 )0.5(\212\003\204 )0.5(\020. \204\024\f\022\r\t, )0.5(\f\023\036)]TJ 0 Tw (-)Tj -0.021 Tw T* (\006\017\026\035\017\f\021, \203\230\230\210\003\204\204 \212\003\204; O\ RCID)Tj /Span<>> BDC ( )Tj EMC (0000-0001-5562-8397)Tj 0.16 Tw T* (\025\031\035\017\022\024\r \212\036\027\017\f \200\026\035\036\027\021\017\ \027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\022\024\r\024\007\017\021\036\035\034 \007\036\021)Tj 0 Tw (-)Tj 0.909 Tw T* (\f\022\024\005 \f\035\031\032\002\t \021\024\030\026\022\024-\026\002\007\ \024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\017\017, )Tj 0.174 Tw T* (\r\030\026\004)Tj /Span<>> BDC ( )Tj EMC [(\227 \007\036\021\f\022\017\005 \b\017\030\031\030\020 \202\210 )0.5(\253\230\035\034\017\027\f\022\026\016 )0.5(\002\024\035\034\027\017\006\026\273; )]TJ 0 Tw T* (ORCID)Tj /Span<>> BDC ( )Tj EMC (0000-0003-2465-807X)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS $ORCID$)Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Nikol)-16(a)15.1(y F. S)-16(hchapov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0036-0546)Tj T* [(R)-24(isal)-15.9(a)15(t I. Dzhav)-15(a)15(tkhanov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4504-8414)Tj T* [(Na)15(t)15(al)-31(ia S. K)25.1(or)-32(cha)-17(gina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5562-8397)Tj T* [(Denis V. K)25.1(ul)-31(ikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2465-807X)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\037\035\030\202\030\206\021\207\037\030\021 \202\006\214\035\003)15(\200\021\202\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ /T1_5 1 Tf 25 0 0 25 512.8644 56.0378 Tm (89)Tj ET endstream endobj 635 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.106 Tw 10 0 0 10 70.8661 724.8299 Tm (\027\017\r\036\007\036\027\027\031\033 \030\026\027\036\036 \022\017\001\ \022\031 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\021\031 \024\022\024\035\024 4 \f\n, \027\036 )Tj 0.417 Tw 0 -1.218 TD (\023\024\r\030\036\032\007\026\016 \f\235\017\027\022\021\036\030\027\t\005\ \026\023\023\026\030\026\021, \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\022\035\026\007\t\r\026\035\017 )Tj 0.25 Tw T* (\001\r\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\033\033 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\033\033 \023\024\030\006\017\033 \203\202\225, \r\t\023\024\ \035)Tj 0 Tw (-)Tj 0.285 Tw T* (\027\016\016 \036\020\024 \024\002\031\032\017\r\026\027\017\036 \007\035\ \016 \036\020\024 \002\024\035\036\036 \220\235\235\036\022\021\017\r\027\ \024\020\024 )Tj 0 Tw T* (\f\024\022\030\026\013\036\027\017\016.)Tj 0.27 Tw T* (\200 \026\022\031\001\036\030\f\022\024\005 \023\030\026\022\021\017\022\ \036 \024\023\017\f\026\027\026 \n\036\021\024\007\017\022\026 \023\035\026\ \f\021\017)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\022\017 \203\202\225 \253\r\027\026\b\035\036\f\021\273 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\024\007\024\r\024\005 \021\030\026\r\n\036 [8]. \202\r\021\024\030\t\ )Tj 0.315 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\027\024\020\024 \007\024\f\021\031\023\ \026 \030\026\007\036\035\016\033\021 \030\036\022\021\024\r\026\020\017\ )Tj 0 Tw (-)Tj 0.47 Tw T* (\027\026\035\034\027\031\033 \023\036\030\036\020\024\030\024\007\022\031\ \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \023\031\002\024\030\036\022\021\026\035\034\027\024\ \005 )Tj 0.425 Tw T* [(\n\t\001\006\t, \n\024\002\017\035\017\031\033\021 )0.5(\022\030\026\016 \023\024\r\030\036\032\007\036\027\027\024\020\024 \f\235\ \017\027\022)]TJ 0 Tw (-)Tj 0.155 Tw T* [(\021\036\030\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.105 0 Td [(\r\t\023\024\035\027\016\033\021 )0.6(\f\235\017\027\022\021\036\030\024\023\035\026\f\021\017\022\031, )0.6(\f\001\017\r\026\016 )0.5(\022\030\026\016 )]TJ 0 Tw -3.105 -1.218 Td (\f\235\017\027\022\021\036\030\026 \r\027\026\b\035\036\f\021 \024\021\007\ \036\035\034\027\t\n\017 \031\035\024\r\t\n\017 \001\r\026\n\017.)Tj -0.045 Tw 0 -1.218 TD (\215\024\f\022\024\035\034\022\031 \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\f\022\024\005 \023\030\026\022\021\017\022\036 \027\036\f\024\ \f\021\024\016\021\036\035\034\027\024\f\021\034 \203\202\225 )Tj 0.044 Tw 0 -1.218 TD (\b\017\030\031\030\020\017 \030\026\f\006\036\027\017\r\026\033\021 \027\ \036 \022\026\022 \026\027\026\021\024\n\017\004\036\f\022\031\033 \023\030\ \024\002\035\036)Tj 0 Tw (-)Tj 0.002 Tw 0 -1.218 TD (\n\031, \026)Tj /Span<>> BDC ( )Tj EMC (\022\026\022 \235\031\027\022\006\017\024\027\026\035\034\027\031\033 \026\ \027\026\035\034\027\031\033 \017\027\022\024\027\021\017\027\036\027\006\ \017\033, )Tj 0.014 Tw T* (\024\023\017\f\026\027\027\t\036 \n\036\021\024\007\017\022\017 \027\026\ \023\030\026\r\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\036\017\030\024\r\026\027\017\036 )Tj 0.007 Tw T* (\203\202\225 \017\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\035\036\027\017\036 \036\020\024 \026\023\017\ \030\026\021\036\035\034\027\024\005 \235\031\027\022)Tj 0 Tw (-)Tj 0.003 Tw T* (\006\017\017 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \017\027\255\036\022\006\017\024\027\027\024\020\024 \r\r\ \036\007\036\027\017\016 \030\026\035\017\004\027\t\b \024\002\255)Tj 0 Tw (-)Tj T* (\036\n\024\002\030\026\031\033\013\017\b \r\036\013\036\f\021\r.)Tj 0.283 Tw T* (\212\035\016 \026\031\021\024\023\030\024\021\036\017\030\024\r\026\027\ \017\016 \203\202\225 \017\f\023\024\035\034\024\r\026\035\017\f\034 \030\ \026)Tj 0 Tw (-)Tj -0.028 Tw T* [(\035\017\004\027\t\036 \n\t\001\006\t, \021\026\022\017\036 \022\026\022\ \002\024\035\034\001\026\016 \016\020\024\007\017\004\027\026\016 $m. \ gl)35.1(u)]TJ 0 Tw (-)Tj -0.044 Tw T* [(teus maximus$ [9], \023\024\030\021\027\016\032\027\026\016 $m. sar)-21.9(t)17(or)-37(ius$, \007\035\017\027\027\026\016 )]TJ 0.1 Tw T* [(\023\030\017\r\024\007\016\013\026\016 )0.5($m. adduc)-15.9(t)17(or l)30(ongus$ )0.5(\017, \027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\024, )]TJ 0.199 Tw T* [(\027\036\032\027\026\016 $m. gr)-33(a)-17(c)-24(il)-30.9(is$ [10]. \207\024\035\034\001\024\036 \022\024\035\017\004\036\f\021\r\ \024 \027\036)]TJ 0 Tw (-)Tj -0.007 Tw T* (\031\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\t\b \017\f\b\ \024\007\024\r \021\026\022\017\b \024\023\036\030\026\006\017\005, \023\ \030\017\r\024)Tj 0 Tw (-)Tj T* (\007\017\035\024 \r)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\036 \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\r\036\007\036\027\017\033 \022\024\035\024\f\021\024\n\t [11].)Tj 0.133 Tw T* [(\202\035\034\021\036\030\027\026\021\017\r\027\t\n\017 )0.5(\f\021\026\035\017 \n\036\021\024\007\017\022\017 \r\r\036\007\036\027\017\ \016 \030\026\035\017\004)]TJ 0 Tw (-)Tj -0.05 Tw T* (\027\t\b \f\017\027\021\036\021\017\004\036\f\022\017\b [12] \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\004\036\f\022\017\b [10] \n\026\021\036\030\ \017)Tj 0 Tw (-)Tj 0.026 Tw T* (\026\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\036 \023\030\024\f\021\ \030\026\027\f\021\r\024, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\017\n\036)Tj 0 Tw (-)Tj -0.044 Tw T* (\027\036\027\017\036 \235\017\017\024\021\036\030\026\023\036\r\021\017\ \004\036\f\022\017\b \n\036\021\024\007\024\r \007\035\016 \031\035\031\004\ \001\036\027\017\016 )Tj 0.17 Tw T* (\235\031\027\022\006\017\017 \203\202\225 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\006 \023\030\024\n\036\032\027\024\f\021\017, \021\026\022\017\036\ \022\026\022 \f\017\f)Tj 0 Tw (-)Tj -0.007 Tw T* (\021\036\n\026 \004\030\036\f\022\024\032\027\024\005 \f\021\017\n\031\035\ \016\006\017\017 \022\030\036\f\021\006\024\r\024\020\024 \024\021\007\036\ \035\026 \023\024)Tj 0 Tw (-)Tj 0.101 Tw T* (\r\024\027\024\004\027\017\022\026, \n\036\021\024\007 \021\017\002\017\ \026\035\034\027\024\005 \027\036)Tj /Span<>> BDC (\005)Tj EMC (\030\024\n\024\007\031\035\016\006\017\017 \017\035\017 )Tj 0 Tw T* (\220\035\036\022\021\030\024\f\021\017\n\031\035\016\006\017\017 \n\026\020\ \027\017\021\027\t\n \023\024\035\036\n.)Tj 0.089 Tw T* (\215\030\036\007\035\024\032\036\027\027\026\016 \027\026\n\017 \024\023\ \036\030\026\006\017\016 \027\026\023\030\026\r\035\036\027\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\031\f\021\030\026)Tj 0 Tw (-)Tj 0.041 Tw T* (\027\036\027\017\036 \017\n\036\027\027\024 \026\027\026\021\024\n\017\004\ \036\f\022\024\020\024 \007\036\235\036\022\021\026 \203\202\225 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024)Tj 0 Tw (-)Tj 0.211 Tw T* (\035\016\036\021 \f\024\b\030\026\027\017\021\034 \026\027\026\021\024\n\ \017\033 \030\036\022\021\026\035\034\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\020\024 )Tj 0.04 Tw T* (\022\026\027\026\035\026. \230\f\023\024\035\034\024\r\026\027\027\t\005\ \027\026\n\017 \n\036\021\024\007 \023\024\r\024\035\017\035 \017\002\ \036)Tj 0 Tw (-)Tj 0.058 Tw T* (\032\026\021\034 \027\036\024\002\b\024\007\017\n\024\f\021\017 \023\024\ \r\021\024\030\027\024\005 \n\024\002\017\035\017\026\006\017\017 \027\017\ \r\036)Tj 0 Tw (-)Tj 0.037 Tw T* (\007\036\027\027\024\005 \022\017\001\022\017. \215\035\026\f\021\017\022\ \026 \023\030\016\n\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n )Tj 0.026 Tw T* [(\024\002\030\026\024\r\026\r\001\036\020\024\f\016 )0.6(\007\036\235\036\022\021\026 )0.5(\027\036\023\030\036\030\t\r\027\t\n )0.6(\001\r\024\n )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.306 0 Td (\r\027\036)Tj 0 Tw (-)Tj 0.167 Tw -20.306 -1.218 Td (\023\030\024\f\r\036\021\027\t\n \235\024\030\n\017\030\024\r\026\027\017\ \036\n \031\035\024\r \023\024\r\024\035\016\036\021 \017\002\036)Tj 0 Tw (-)Tj 0.179 Tw T* (\032\026\021\034 \r\t\r\036\007\036\027\017\016 \026\013\017\021\027\024\ \005 \022\017\001\036\004\027\024\005 \f\021\024\n\t, \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 )Tj 0.233 Tw T* (\027\017\022\024\020\024 \030\017\f\022\026 \017\027\235\036\022\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024)Tj 0 Tw (-)Tj T* (\f\021\024\016\021\036\035\034\027\024\f\021\017 \001\r\026.)Tj 0.135 Tw T* [(\210\021\007\036\035\034\027\t\005 )0.6(\017\027\021\036\030\036\f )0.5(\023\030\036\007\f\021\026\r\035\016\036\021 )0.5(\023\026\021\024\035\024\020\024\n\024\030\235\024\035\024)]TJ 0 Tw (-)Tj 0.017 Tw T* (\020\017\004\036\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036\ \030\036\036\006\017\030\024\r\026\027\027\024\020\024 \031\004\026\f\021\ \022\026 \023\036)Tj 0 Tw (-)Tj -0.002 Tw T* (\030\036\007\027\036\005 \f\021\036\027\022\017 \023\030\016\n\024\005 \022\ \017\001\022\017, \023\024\f\022\024\035\034\022\031 \023\024\021\030\036\ \002\027\024\f\021\034 )Tj 0.124 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.83 0 Td [(\030\036\036\022\006\017\017 )0.5(\027\017\r\036\007\036\027\027\024\005 )0.6(\022\017\001\022\017 )0.6(\022\030\026\005\027\036 )0.5(\030\036\007\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.862 0 Td (\021\036\n )Tj 0.057 Tw -20.692 -1.218 Td [(\002\024\035\036\036 )0.5(\023\024\035\027\024\f\035\024\005\027\024\005 \002\017\024\023\f\017\017\ )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.538 0 Td [(\220\021\024\n )0.5(\027\036 \023\030\024\r\024\007\016\021. )]TJ 0.249 Tw -14.538 -1.218 Td (\217\036\036\006\017\030\024\r\026\027\027\t\005 \f\036\020\n\036\027\021\ \016\r\035\016\036\021\f\016 \f\021\036\027\022\024\005 \023\030\016\n\024\ \005 )Tj 0.251 Tw T* (\022\017\001\022\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\t\f\021\017\035\022\026 \023\030\036\007\f\021\026\r\035\ \036\027\026 \021\024\035\f\021\024\022\017)Tj 0 Tw (-)Tj 0.309 Tw T* (\001\036\004\027\t\n \220\023\017\021\036\035\017\036\n \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\b\024\007\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\f\035\024\005\027\024\n\031 )Tj -0.023 Tw T* (\023\035\024\f\022\024\n\031 \024\030\024\020\024\r\036\r\026\033\013\036\ \n\031. \200)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\024\005 \023\035\026\f\021\017\027\022\036\ )Tj 0.2 Tw 23.244 64.543 Td (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\035\024\ \021\027\024\f\021\034 \022\035\036\021\024\004\027\024\020\024 \017\027\ \235\017\035\034)Tj 0 Tw (-)Tj -0.014 Tw T* (\021\030\026\021\026 \027\036\f\022\024\035\034\022\024 \023\024\r\t\001\ \036\027\026 \026)Tj /Span<>> BDC ( )Tj EMC 12.406 0 Td [(\f\004\036\021 \035\017\n\235\024\006\017\021\024\r, )0.5(\023\035\026)]TJ 0 Tw (-)Tj 0.5 Tw -12.406 -1.218 Td (\n\026\021\017\004\036\f\022\017\b \022\035\036\021\024\022, \024\023\030\ \036\007\036\035\016\033\021\f\016 \035\017\n\235\026\021\017\004\036\f\022\ \017\036 )Tj 0.194 Tw T* (\235\024\035\035\017\022\031\035\t \f\024 \f\r\036\021\035\t\n\017 \006\036\ \027\021\030\026\n\017. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\005 )Tj 0.448 Tw T* (\024\f\027\024\r\036 \r\t\016\r\035\036\027 \024\004\026\020\024\r\t\005\ \f\022\035\036\030\024 \017)Tj /Span<>> BDC ( )Tj EMC (\035\017\023\024\n\026\021\024. )Tj 0.477 Tw T* (\200\017\031\026\035\017\017\030\031\033\021\f\016 \027\036\030\r\027\t\ \036 \r\024\035\024\022\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\036 )Tj 0.125 Tw 0 -1.218 TD [(\027\036\030\r\027\t\036 )0.5(\f\023\035\036\021\036\027\017\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 9.285 0 Td [(\022\030\031\023\027\t\n\017 )0.5(\020\026\027\020\035\017\024\027\t\n\017 )0.6(\022\035\036\021)]TJ 0 Tw (-)Tj 0.273 Tw -9.285 -1.218 Td (\022\026\n\017. \204\t\001\036\004\027\t\036 \f\035\024\017 \023\030\024\ \f\035\036\032\017\r\026\033\021\f\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 )Tj 0.363 Tw 0 -1.218 TD (\023\036\030\036\b\024\007\026 \220\023\017\021\036\035\017\016, \020\017\ \023\036\030\021\030\024\235\017\030\024\r\026\027\t, \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.119 Tw T* [(\023\036\030\036\b\024\007\026, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.201 0 Td [(\022\030\026\036 )0.5(\024\023\030\036\007\036\035\016\036\021\f\016 )0.5(\n\036\032\n\t\001\036\004\027\t\005 )0.6(\f\022\035\036)]TJ 0 Tw (-)Tj 0.019 Tw -5.201 -1.218 Td (\030\024 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\030\024\235\017\004\036\f\022\017\036 \017\n\036\027\036\ \027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \023\036\030\036\b\024)Tj 0 Tw (-)Tj 0.052 Tw T* (\007\026 \220\023\017\021\036\035\017\016 \024\023\030\036\007\036\035\016\ \033\021\f\016 \b\026\024\021\017\004\027\024 \030\026\f\023\024\035\024\ \032\036\027\027\t\036 )Tj 0 Tw 0 -1.218 TD (\020\035\026\007\022\024\n\t\001\036\004\027\t\036 \220\035\036\n\036\027\ \021\t $\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6$.)Tj ET q 303.307 230.57 221.102 321.351 re W n q /GS0 gs 221.1023475 0 0 321.4506404 303.307086 230.4707732 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.058 Tw 9 0 0 9 303.3071 219.7701 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \240\022\021\033\034\024\021\034\f\022\n\016\024\021\034\016 \022\031\034\ \025\033\037\003\016\020\022\016 \033\016\031\016\006\022\033\034\036\037\ \020\020\034)Tj 0 Tw (-)Tj 0.061 Tw 0 -1.2 TD (\013\034 \023\n\037\024\035\021\037 \f\033\030\b\034\t \021\022\004\021\022\ $\034\021\033\037\024\021\037 \013\016\b\037\035\034\021\024\022\027\022\ \020 \022)Tj /Span<>> BDC ( )Tj EMC (\220\034\031\022\020, )Tj 0.225 Tw T* (\023\036\016\027\022\n\016\020\022\016 \001250$. 1)Tj /Span<>> BDC ( )Tj EMC (\227 \017\033\037\013\b\016\020\035 \005\022\024\035\037\027\007\020\034\ \013\034 \023\n\037\024\035\021\037 )Tj 0.086 Tw T* (\f\033\030\b\034\t \021\022\004\021\022 $A)Tj /Span<>> BDC ( )Tj EMC (\227 \031\034\020\037 \f\016\033\016\001\034\005\037 \220\f\022\035\016\027\ \022\030 \034\035 \035\034\027\024\035\034)Tj 0 Tw (-)Tj 0.266 Tw T* (\021\022\004\016\n\020\034\013\034 \021)Tj /Span<>> BDC ( )Tj EMC (\b\020\034\013\034\024\027\034\t\020\034\b\023 \f\027\034\024\021\034\b\023\ \034\033\034\013\034\036\016\036\037\026\217\016\b\023$, )Tj -0.007 Tw T* (2)Tj /Span<>> BDC ( )Tj EMC (\227 \023\n\037\024\035\034\021 \024)Tj /Span<>> BDC ( )Tj EMC (\027\022\b\017\034\017\034\027\027\022\021\023\027\030\033\020\037\030 \013\ \022\f\016\033\f\027\037\031\022\016\t, \024\021\027\016\033\034)Tj 0 Tw (-)Tj 0.081 Tw T* (\031\034\b \022)Tj /Span<>> BDC ( )Tj EMC (\027\022\f\034\b\037\035\034\031\034\b \f\034\005\024\027\022\031\022\024\ \035\034\t \034\024\020\034\036\032, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \017\033\037\013\b\016\020\035 )Tj 0.226 Tw T* (\b\032\004\016\n\020\034\013\034 \024\027\034\030 \033\016\031\016\006\022\ \033\034\036\037\020\020\034\t \021\022\004\021\022 $B)Tj /Span<>> BDC ( )Tj EMC (\227 \001\037\034\035\022\n\020\034 )Tj 0.128 Tw T* [(\033\037\024\f\034\027\034\003\016\020\020\032\016 )0.7(\013\027\037\005\021\034\b\032\004\016\n\020\032\016 )0.6(\220\027\016\b\016\020\035\032, )0.7(C)]TJ /Span<>> BDC ( )Tj EMC 19.994 0 Td [(\227 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\024\f\021\026\r\026\035\024\f\034 \f\021\026\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.105 Tw T* (\002\017\035\034\027\t\n, \r)Tj /Span<>> BDC ( )Tj EMC 5.081 0 Td (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC 3.52 0 Td [(\004\036\n \002\t\035\026 )0.5(\023\036\030\036\r\036\007\036\027\026 \r)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\035\026\021\031.)10( )]TJ 0.713 Tw -8.601 -1.218 Td [(\224\036\004\036\027\017\036 \030\026\027\027\036\020\024 \023\024\f\035\ \036\024\023\036\030\026\006\017\024\027\027\024\020\024 \023\036\030\017\ \024\007\026)10( )]TJ 0.297 Tw T* (\002\t\035\024 \020\035\026\007\022\024\036, \023\030\024\r\024\007\017\035\ \026\f\034 \023\024\007\007\036\030\032\017\r\026\033\013\026\016 \017\027\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.497 Tw T* [(\235\031\017\024\027\027\026\016 )0.5(\021\036\030\026\023\017\016, )0.5(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\026\016 )0.5(\021\036\030\026\023\017\016,)10( )]TJ 0.321 Tw T* [(\023\030\024\007\035\036\027\027\026\016 )0.5(\220\023\017\007\031\030\026\035\034\027\026\016 )0.5(\026\027\026\035\020\036\017\016. )0.5(\203\026)]TJ /Span<>> BDC ( )Tj EMC 18.756 0 Td [(3 )0.5(\f\031\021\022\017)10( )]TJ 0.089 Tw -18.756 -1.218 Td [(\023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 )0.5(\002\t\035 )0.5(\031\007\026\035\036\027 )0.5(\220\023\017\007\031\030\026\035\034\027\t\005 )0.5(\022\026\021\036\021\036\030,)10( )]TJ 0.075 Tw T* (\031\030\036\021\030\026\035\034\027\t\005 \022\026\021\036\021\036\030,\ \027\026\004\026\035\026 \r\t\f\026\032\017\r\026\021\034\f\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\031\027\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.021 Tw T* (\021\026. \003\026)Tj /Span<>> BDC ( )Tj EMC (\r\030\036\n\016 \027\026\002\035\033\007\036\027\017\016 \007\026\027\027\ \t\b \026)Tj /Span<>> BDC ( )Tj EMC [(\b\017\030\031\030\020\017\004\036\f\022\017\036)10( )]TJ 0.038 Tw T* (\024\f\035\024\032\027\036\027\017\016 \027\036 \023\024\035\031\004\036\ \027\t, \r)Tj /Span<>> BDC ( )Tj EMC [(\035\026\002\024\030\026\021\024\030\027\t\b \026\027\026\035\017\026\b\ )10( )]TJ 0.153 Tw T* (\002\036 \r\024\f\023\026\035\017\021\036\035\034\027\t\b \017\n\036\027\ \036\027\017\005. \217\036\002\036\027\022\031 \023\030\024\r\024\007\017\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.133 Tw T* (\035\026\f\034 \n\036\f\021\027\026\016 \021\036\030\026\023\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\r\017\007\036 \024\004\017\f\021\017\021\036\035\034\027\t\b \022\035\017\ \n)10( )]TJ 0.145 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\036\032\036\007\027\036\r\027\t\b \023\036\030\036\r\016\024\022. \221\ \r\t \026\032\017\035\017 \023\036\030\r\017\004\027\t\n)9.9( )]TJ 0.229 Tw T* (\027\026\021\016\032\036\027\017\036\n. \203\026)Tj /Span<>> BDC ( )Tj EMC [(6 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ \030\036\002\036\027\024\022)10( )]TJ -0.007 Tw T* (\002\t\035 \r\t\023\017\f\026\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\n\002\031\035\026\021\024\030\027\024\036 \035\036\004\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc T* (\030\017\021\036\035\034\027\024\n \f\024\f\021\024\016\027\017\017.)Tj 0 Tc 0.306 Tw T* (\200 \027\026\f\021\024\016\013\017\005 \n\024\n\036\027\021 \022\026\021\ \026\n\027\036 \f\024\f\021\026\r\035\016\036\021 2 \020\024\007\026. )Tj 0.276 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\027\026\n\017\004\036\f\022\024\n \027\026\002\035\033\007\036\027\ \017\017 \024\021\n\036\004\036\027\026 \023\024\035\024\032\017)Tj 0 Tw (-)Tj 0.342 Tw T* (\021\036\035\034\027\026\016 \007\017\027\026\n\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \r\024\f\f\021\026\027\024\r\035\036\027\017\016 \023\024\ \t\r\026 )Tj 0.048 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\033, \031\030\020\036\027\021\027\024\020\ \024 \031\007\036\030\032\026\027\017\016 \022\026\035\026. \211)Tj /Span<>> BDC ( )Tj EMC (\030\036\002\036\027)Tj 0 Tw (-)Tj 0.279 Tw T* [(\022\026 \f\024\b\030\026\027\016\033\021\f\016 \027\026\030\031\001\036\ \027\017\016 )0.5(\220\r\026\022\031\026\021\024\030\027\024\005 \235\031\027\022\006\017\017\ )]TJ 0.186 Tw T* [(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017, )0.5(\004\021\024 )0.5(\024\002\031\f\035\026\r\035\017\r\026\036\021 )0.5(\f\022\024\023\035\036\027\017\036 )0.6(\022\026\035\024)]TJ 0 Tw (-)Tj 0.016 Tw T* (\r\t\b \n\026\f\f \r)Tj /Span<>> BDC ( )Tj EMC (\026\n\023\031\035\036 \023\030\016\n\024\005 \022\017\001\022\017. \215\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\017\r\024\035\034\027\024\n )Tj -0.003 Tw T* (\f\024\022\030\026\013\036\027\017\017 \026\027\031\f\026 \024\023\030\036\ \007\036\035\016\036\021\f\016 \030\026\r\027\024\n\036\030\027\024\036 \ \f\024\022\030\026)Tj 0 Tw (-)Tj 0.033 Tw T* (\013\036\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\005 \024\022\030\031\032\027\024\f\021\017, \024\007\027\026\022\ \024 \021\024\027\031\f \n\t\001\036\004\027\024\020\024 )Tj 0.013 Tw T* (\022\024\035\034\006\026 \024\f\021\026\036\021\f\016 \f\027\017\032\036\ \027\027\t\n. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \022\024\027\021\030\024\035\034\027\024)Tj 0 Tw (-)Tj -0.003 Tw T* (\020\024 \211\003\230 \f\021\030\031\022\021\031\030 \021\026\024\r\024\ \020\024 \007\027\026 \024\021\n\036\004\036\027\t \023\030\017\027\026\ \022\017 \235\017)Tj 0 Tw (-)Tj 0.071 Tw T* (\002\030\024\027\t\b \017\n\036\027\036\027\017\005 \f\021\036\027\022\ \017 \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.201 Tw T* [(\023\024\r\t\001\036\027\017\016 )0.5(\036\036 \220\b\024\020\036\027\027\024\f\021\017, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.185 0 Td [(\220\021\024\n \024\021\n\036\004\036\027\024 )0.5(\017)]TJ 0 Tw (-)Tj 0.138 Tw -14.185 -1.218 Td (\016\027\017\036 \026\027\026\035\034\027\024\020\024 \022\026\027\026\035\ \026 \007\024)Tj /Span<>> BDC ( )Tj EMC (10 \n\n. \203\202\225 \f\017\n\n\036\021\030\017\004\036\027 )Tj 0.076 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \036\020\024 \004\026\f\021\017, \027\024 \021\026\ \022\032\036 \024\021\n\036\004\026\036\021\f\016 )Tj -0.008 Tw T* (\023\024\r\t\001\036\027\017\036 \220\b\024\020\036\027\027\024\f\021\017\ . \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f\024 \f\027\017\032\036\027\017\036\n \021\024\027\031)Tj 0 Tw (-)Tj 0.001 Tw T* [(\f\026 )0.5(\203\202\225 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.75 0 Td [(\f\021\030\031\022\021\031\030\027\t\n\017 )0.6(\027\026\030\031\001\036\027\017\016\n\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.59 0 Td [(\r\017\007\036 )0.5(\235\017\002\030\024\026 )]TJ 0.587 Tw -16.341 -1.218 Td (\027\017\r\036\007\036\027\027\024\005 \022\017\001\022\017 \023\030\024\ \r\024\007\017\021\f\016 \235\036\030\n\036\027\021\026\021\017\r\027\026\ \016 )Tj 0.076 Tw T* (\023\030\024\021\036\024\035\017\021\017\004\036\f\022\026\016 \021\036\030\ \026\023\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\026\023\017\016 \002\017\024\035\024\020\017\004\036\f\022\024\ \005 )Tj 0 Tw T* (\024\002\030\026\021\027\024\005 \f\r\016\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 517.8039 Tm [(\037\036)10(\032\223\212\226\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.138 Tw 10 0 0 10 274.9606 493.4479 Tm [(\207\024\035\034\001\017\027\f\021\r\024 )0.5(\024\f\035\024\032\027\036\027\017\005 \023\024\f\035\036 \022\024\030\030\ \036\022\006\017\017 \026\027\024\030\036\022)]TJ 0 Tw (-)Tj 0.122 Tw T* [(\021\026\035\034\027\t\b )0.5(\023\024\030\024\022\024\r \b\024\030\024\001\024 \017\r\036\f\021\027\t\ )0.5(\b\017\030\031\030\020\026\n. )0.5(\025)]TJ /Span<>> BDC ( )Tj EMC (\027\017\n )Tj -0.004 Tw T* (\024\021\027\024\f\017\021\f\016 \027\036\007\036\030\032\026\027\017\036\ \022\026\035\026, \022\024\021\024\030\024\036 \f\r\016\t\r\026\033\021\ \f)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.204 Tw T* (\007\024\030\026\r\017\021\017\036\n \n\t\001\036\004\027\024\020\024 \026\ \023\023\026\030\026\021\026 \017\035\017 \027\026\030\031\001\036\027\017\ \036\n )Tj 0.314 Tw T* (\017\027\027\036\030\r\026\006\017\017 \r\f\035\036\007\f\021\r\017\036 \ \023\026\021\024\035\024\020\017\017 \022\030\036\f\021\006\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f)Tj 0 Tw (-)Tj 0.076 Tw T* (\021\026\035\034\027\024\020\024 \024\021\007\036\035\026 \f\023\017\027\ \027\024\020\024 \n\024\020\026; \030\026\027\036\r\026\016 \017\027\235\ \036\022\006\017\016, )Tj 0.576 Tw T* (\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \030\026\027\ \t, \030\036\021\030\026\022\006\017\016 \027\017\r\036\007\036\027\027\ \024\005 )Tj -0.013 Tw T* (\022\017\001\022\017, \r\f\035\036\007\f\021\r\017\036 \004\030\036\n\036\ \030\027\024\020\024 \027\026\021\016\032\036\027\017\016 \017\035\017 \027\ \036\007\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\f\021\026\021\024\004\027\024\020\024 \022\030\024\r\024\f\027\026\002\032\ \036\027\017\016 \022\017\001\022\017; \r\t\023\026\007\036\027\017\036 \ \023\030\016)Tj 0 Tw (-)Tj 0.136 Tw T* (\n\024\005 \022\017\001\022\017, \022\024\021\024\030\024\036 \f\r\016\t\ \r\026\033\021 \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\b\017\n \030\026\r\017\021\017\036\n )Tj 0.061 Tw T* [(\021\026\024\r\024\020\024 \007\027\026 )0.5([3]. \210\023\030\036\007\036\035\036\027\017\036 )0.5(\032\036 )0.5(\r\036\007\031\013\036\005 \023\030\017\004\017\027\t )]TJ 0.105 Tw T* (\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \027\026\030\031\001\036\027\017\016 \006\036\035\024\f\021\ )Tj 0 Tw (-)Tj -0.029 Tw T* (\027\024\f\021\017 \203\202\225 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\027\024\n \036\020\024 \023\030\024\017\r\024\ \035\034\027\024\n \f\024\022\030\026)Tj 0 Tw (-)Tj 0.111 Tw T* (\013\036\027\017\017, \023\024\r\024\035\016\036\021 \023\030\036\007\035\ \024\032\017\021\034 \f\023\024\f\024\002 \023\026\021\024\020\036\027\036\ \021\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\020\024 \035\036\004\036\027\017\016.)Tj 0.132 Tw T* (\025 \f\024\032\026\035\036\027\017\033, \r)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\f\022\024\005 \023\030\026\022\021\017\022\036 \007\026\027\ \027\024\005 \023\030\024\002\035\036\n\036 )Tj 0.185 Tw T* (\027\036 \031\007\036\035\036\027\024 \007\024\f\021\026\021\024\004\027\ \024 \r\027\017\n\026\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \007\024)Tj 0 Tw (-)Tj 0.029 Tw T* (\f\021\031\023\027\024\005 \035\017\021\036\030\026\021\031\030\t \031\007\ \026\035\024\f\034 \r\t\016\r\017\021\034 \023\024\021\036\027\006\017\026\ \035\034\027\031\033 )Tj 0.1 Tw T* [(\020\030\031\023\023\031 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.52 0 Td [(\026\027\026\035\034\027\024\005 )0.6(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\034\033, )0.6(\022\024)]TJ 0 Tw (-)Tj 0.043 Tw -8.52 -1.218 Td (\021\024\030\031\033 \r)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\016\b \026\r\021\024\030\t \024\021\ \027\036\f\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\027\021\031 \r\027\036 )Tj -0.02 Tw T* (\f\235\017\027\022\021\036\030\027\024\020\024 \027\017\r\036\007\036\027\ \017\016, \023\024\f\022\024\035\034\022\031 \026\027\031\f \027\026\b\024\ \007\017\035\f\016 )Tj 0.011 Tw T* [(\r\027\036 \006\036\027\021\030\026 )0.5(\203\202\225. \200)]TJ /Span<>> BDC ( )Tj EMC 7.731 0 Td [(\002\024\035\034\001\017\027\f\021\r\036 )0.5(\f\035\031\004\026\036\r )0.5(\024\023\036\030\026\021\017\r\027\024\036 )]TJ -0.031 Tw -7.731 -1.218 Td (\r\n\036\001\026\021\036\035\034\f\021\r\024 \026\022\035\033\004\026\035\ \024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\n \027\017\r\036\007\036\027\017\017 )Tj 0.07 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 [4,5]. \224\026\022\024\020\024\ \032\036 \n\027\036\027\017\016 \023\030\017\007\036\030\032\017\r\026)Tj 0 Tw (-)Tj -0.017 Tw T* [(\033\021\f\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(Bischof)-56(f )0.5(A. \f)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. )0.5([6], \r)]TJ /Span<>> BDC ( )Tj EMC 13.298 0 Td [(\f\r\024\036\005 )0.5(\030\026\002\024\021\036 \023\024\022\026\026)]TJ 0 Tw (-)Tj 0.078 Tw -13.298 -1.218 Td (\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\024\005 \030\036\022\024\027\f\021\030\031\022\ \021\017\r\027\024\005 \024\023\036\030\026\006\017\017 \002\t\035\024 )Tj 0.494 Tw T* (\r\027\036\f\235\017\027\022\021\036\030\027\024\036 \027\017\r\036\007\ \036\027\017\036 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\026\022\021\027\t\n )Tj 0.128 Tw T* (\203\202\225. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036, \036\f\035\017 \032\036 \f\235\017\027\022\021\036\ \030 \002\t\035 \026\007\036\005\f\021\r\024\r\026\027 )Tj 0.025 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\017\004\027\024\005 \024\023\036\030\026\006\017\017, \007\ \036\021\017 \027\026\023\030\026\r\035\016\035\017\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj T* (\020\030\026\n\n\031 \022\024\027\021\030\024\035\016 \030\026\002\024\021\ \t \022\017\001\036\004\027\017\022\024\n.)Tj 0.561 Tw T* (\217\036\022\024\027\f\021\030\031\022\006\017\016 \026\027\026\035\034\027\ \024\020\024 \f\235\017\027\022\021\036\030\026 \023\031\021\036\n \f\002\ \026)Tj 0 Tw (-)Tj 0.512 Tw T* (\030\017\r\026\027\017\016 \n\t\001\036\004\027\024\020\024 \022\024\035\ \034\006\026 \r\024\022\030\031\020 \027\017\r\036\007\036\027\027\024\005\ )Tj 0.186 Tw T* [(\022\017\001\022\017 \002\t\035\026 \023\030\036\007\035\024\032\036\027\ \026 Kr)-32(ois \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [7] \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\036\005 )Tj 0.269 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\005 \017\027\022\024\027\021\017\027\036\027\ \006\017\036\005 \023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\ \022\024\020\024 )Tj 0.053 Tw T* [(\035\036\004\036\027\017\016 \002\024\035\036\027\017 )0.5(\206\017\030\001\023\030\031\027\020\026. \202\r\021\024\030\t \n\024\002\ \017\035\017\024\r\026\035\017 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \002\033\037\036\020\016\020\022\016 \037\020\037\027\007\020\034\t \b\037\ \020\034\b\016\035\033\022\022 \023)Tj /Span<>> BDC ( )Tj EMC (\f\037\006\022\016\020\035\037 \005\034)Tj /Span<>> BDC ( )Tj EMC [(\034\f\016\033\037\006\022\022 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\n\016\033\016\031 2 \013\034\005\037 \f\034\024\027\016 \034\f\016\033\037\ \006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 3.324 0 Td [( C)1.2(o)-4(m)-1(p)-6.3(a)-4.1(r)-39(i)6.6(s)0.5(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5(na)-4.5(l ma)-5.1(n)-2.4(o)-4(m)-5.2(e)-8.6(t)-9.6(r)-43.8(y i)3.9(n p)-6.3(a)-9.1(t)-29.1(i)-1.4(e)-7(n)-0.6(t b)-10.1(ef)-13.4(o)-3(r)-2(e s)6.8(u)1.6(r)-2(g)-6.8(e)-6(r)-43.8(y a)-5.1(n)-4.7(d 2 y)-3.4(e)-7.5(a)-4.2(r)-14.9(s a)-0.6(f)-50.9(t)-1.6(e)-6(r s)6.7(u)1.6(r)-2(g)-6.8(e)-6(r)-43.7(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 365.9193 715.181 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 266.7067 703.7117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 703.7117 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 682.6505 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 682.6505 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1892 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 671.1892 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 671.1892 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.7279 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 629.3167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 266.7067 659.7279 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 629.3167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 365.9193 659.7279 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 629.3167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 629.3167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 629.0667 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 629.0667 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 365.9193 629.0667 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 496.313 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 617.6053 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 617.6053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 617.6053 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 606.144 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 606.144 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 606.144 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 594.6827 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 594.6827 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 594.6827 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 583.2215 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 572.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 583.2215 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 572.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 583.2215 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 572.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 572.0102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 571.7602 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 560.549 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 571.7602 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 560.549 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 571.7602 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 560.549 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 560.549 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 560.299 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 42.7697 549.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 560.299 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 266.7067 549.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 560.299 cm 0 0 m 130.644 0 l S Q q 1 0 0 1 365.9193 549.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 549.0876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 548.8376 cm 0 0 m 224.187 0 l S Q q 1 0 0 1 266.7067 548.8376 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 365.9193 548.8376 cm 0 0 m 130.644 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 137.9984 706.5463 Tm (\200\004\006\004\214\r\003\006)Tj 19.508 0 Td (\031\002 \002\212\r\006\004\204\t\t)Tj 13.596 0 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t)Tj /T1_1 1 Tf -44.654 -1.433 Td (\224\024\027\031\f \f\235\017\027\022\021\036\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036)Tj 28.735 0 Td (\f\027\017\032\036\027 $56% \024\021 \f\030\036\007\027\036\005 )Tj 2.894 -1.2 Td (\r\036\035\017\004\017\027\t$)Tj 9.13 1.2 Td (\f\027\017\032\036\027 $51% \024\021 \f\030\036\007\027\036\005 \r\036\035\ \017\004\017\027\t$)Tj -40.76 -2.633 Td (\215\030\017\030\024\f\021 \007\026\r\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\n\n\026\030\027\024\n \r\024\035\036\r\024\n \f\024\022\030\026\013\ \036\027\017\017 $mm Hg$)Tj 33.339 0 Td (32)Tj 14.1 0 Td (146)Tj -47.439 -1.433 Td (\023\030\017 \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\ \017 $c$)Tj 33.246 0 Td (5,6)Tj 14.35 0 Td (5,6)Tj -47.596 -1.433 Td (\025\026\001\035\036\r\024\005 \030\036\235\035\036\022\f)Tj 29.089 0 Td (\217\036\235\035\036\022\021\024\030\027\026\016 \030\036\026\022\006\017\ \016 )Tj 2.967 -1.2 Td (\f\027\017\032\036\027\026)Tj 11.383 1.2 Td (\217\036\235\035\036\022\021\024\030\027\026\016 \030\036\026\022\006\017\ \016 )Tj -0.364 -1.2 Td (\f\024\b\030\026\027\036\027\026, \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\027\007\036\027\006\017\036\005 )Tj -2.215 -1.2 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\020\017\023\024\022\024\027\021\030\026\022\021\017\035\034\027\024\f\021\ \017 \f\235\017\027\022\021\036\030\026)Tj -40.86 -1.433 Td (\215\026\030\026\n\036\021\030\t \r\t\027\024\f\035\017\r\024\f\021\017 \ \f\024\022\030\026\013\036\027\017\016)Tj 0 -1.433 TD (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 $\f$\ )Tj 32.996 0 Td (20,6)Tj 14.35 0 Td (20,6)Tj -47.346 -1.433 Td (\f\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 $mm Hg$)Tj 33.339 0 Td (13)Tj 14.35 0 Td (80)Tj -47.689 -1.433 Td (\023\030\017\030\024\f\021 \007\026\r\035\036\027\017\016 $mm Hg$)Tj 33.339 0 Td (35)Tj 14.35 0 Td (20)Tj -47.689 -1.433 Td (\023\035\024\013\026\007\034 \023\024\007 \022\030\017\r\024\005 $mm Hg\ .c$)Tj 33.089 0 Td (274)Tj 14.1 0 Td (1657)Tj -47.189 -1.433 Td (\217\036\031\035\034\021\026\021\t \r\t\021\026\035\022\017\r\026\027\017\ \016$mm Hg$)Tj 33.339 0 Td (20)Tj 14.35 0 Td (86)Tj -47.689 -1.433 Td (% \030\026\f\f\035\026\002\035\036\027\017\016)Tj 33.339 0 Td (22)Tj 14.6 0 Td (9)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\037\035\030\202\030\206\021\207\037\030\021 \202\006\214\035\003)15(\200\021\202\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ /T1_5 1 Tf 25 0 0 25 512.9144 56.0378 Tm (87)Tj ET endstream endobj 632 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.301 Tw 10 0 0 10 70.8661 724.8299 Tm (\007\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\027\026\n\017\022\036 \024\021\n\036\004\026\035\024\f\034 \031\ \n\036\027\034\001\036\027\017\036 \023\030\024\f\r\036\021\026 )Tj 0.2 Tw 0 -1.218 TD (\017\016\027\017\016 \026\027\031\f\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (10 \n\n $\r \027\024\030\n\036 \027\036 \027\026\002\035\033\007\026\036\ \021\f\016$, )Tj 0.121 Tw T* (\023\036\030\036\007\027\016\016 \004\026\f\021\034 \203\202\225 \017-\ \026 \030\031\002\006\026 \r\017\031\026\035\017\017\030\024\r\026\035\ \026\f\034 )Tj 0.37 Tw T* (\235\030\026\020\n\036\027\021\026\030\027\024, \027\024 \030\026\n\036\ \030\t \036\036 \002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t )Tj 0.154 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\005 \023\024\030\006\017\036\005. \200\024\035\036\r\024\ \036 \f\024\022\030\026\013\036\027\017\036 \r\017\031\026\035\017\017\ )Tj 0 Tw (-)Tj 0.09 Tw T* (\030\024\r\026\035\024\f\034 \022\026\022 \f\024\004\036\021\026\027\027\ \024\036 \007\r\017\032\036\027\017\036 \023\036\030\036\007\027\036\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\026\007)Tj 0 Tw (-)Tj 0.113 Tw 0 -1.218 TD (\027\036\005 \023\024\030\006\017\005 \203\202\225 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\017 \023\024\035\027\t\n \026\n\t\ \022\026\027\017\036\n )Tj 0 Tw 0 -1.218 TD (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 $\217\017\ \f.)Tj /Span<>> BDC ( )Tj EMC (5$.)Tj -0.025 Tw T* (\215\030\017 \f\030\026\r\027\036\027\017\017 \f\235\017\027\022\021\036\ \030\024\n\036\021\030\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\030\036\002\036\027\022\026 \024\021\n\036\004\036\027\026 )Tj -0.042 Tw T* (\023\024\035\024\032\017\021\036\035\034\027\026\016 \007\017\027\026\n\017\ \022\026 \r\024\f\f\021\026\027\024\r\035\036\027\017\016 \021\024\027\031\ \f\026 \203\202\225 )Tj 0.131 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\031\n\n\026\030\027\024\005 \f\024\022\030\026\021\017\021\036\035\034\ \027\026\016 \f\023\024\f\024\002\027\024\f\021\017 \026\027\026\035\034\ \027\t\b )Tj 0.001 Tw T* (\f\235\017\027\022\021\036\030\024\r $\224\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1$. \215\030\024\r\036\007\036\027\027\024\036 \024\002\f\035\036\007\024\ \r\026\027\017\036 \027\036 )Tj 0.075 Tw 0 -1.218 TD (\r\t\016\r\017\035\024 \026\027\026\021\024\n\017\004\036\f\022\017\b \027\ \026\030\031\001\036\027\017\005 \023\024\f\035\036 \024\023\036\030\026\ \006\017\017, )Tj 0.055 Tw 0 -1.218 TD (\004\021\024 \023\024\r\024\035\017\035\024 \024\023\030\036\007\036\035\ \017\021\034 \023\030\017\004\017\027\024\005 \027\036\r\024\n\024\032\027\ \024\f\021\017 )Tj 0.044 Tw 0 -1.218 TD (\031\030\020\036\027\021\027\024\020\024 \031\007\036\030\032\026\027\017\ \016 \024\021\f\031\021\f\021\r\017\036 \024\023\t\021\026 \023\030\017\n\ \036\027\036\027\017\016 )Tj 0.003 Tw T* [(\f\235\017\027\022\021\036\030\026 )0.6(\007\035\016 )0.5(\220\021\024\005 )0.5(\006\036\035\017. )0.6(\212\035\016 )0.5(\030\036\001\036\027\017\016 )0.5(\007\026\027\027\024\005 )0.6(\023\030\024\002)]TJ 0 Tw (-)Tj 0.335 Tw T* (\035\036\n\t \027\026\027\026\004\036\027\026 \021\036\030\026\023\017\016\ \002\017\024\035\024\020\017\004\036\f\022\024\005 \024\002\030\026\021\ \027\024\005 )Tj 0 Tw T* (\f\r\016\017.)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\037\013\b\013\205\n\020\017\013\206 \020\211\205\005\206 2)Tj /T1_0 1 Tf -0.014 Tw 0 -1.218 TD (\212\036\r\024\004\022\026 10 \035\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\017\033\035\036 2022 \020\024\007\026 \027\026\b\024\007\017\035\026\f\034\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036)Tj 0 Tw (-)Tj -0.082 Tw T* (\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\230\035\034\017\027\f\022\024\005 \002\024\035\034\027\017\006\036 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034\033 \203\202\ \225. )Tj 0.174 Tw 23.244 25.574 Td (\215\024\f\035\036 \030\024\032\007\036\027\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\030\036\002\036\027\022\026 \002\t\035\026 \r\t\016\r\035\036\027\026 \026\ \021\030\036\017\016 )Tj 0.14 Tw T* (\026\027\031\f\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024-\023\036\030\017\027\036\026\035\034\027\024\005 \235\ \017\f\021\031\035\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r \r\024\030\026\f\021\036 )Tj 0.028 Tw T* (3 \n\036\f\016\006\036\r \032\017\027\017 \036\005 \002\t\035\026 \r\t\023\ \024\035\027\036\027\026 \024\007\027\024\n\024\n\036\027\021\027\026\016\ )Tj 0.186 Tw T* (\030\026\007\017\022\026\035\034\027\026\016 \022\024\030\030\036\022\006\ \017\016 \023\024\030\024\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\027\024\020\024 )Tj -0.014 Tw T* (\007\024\f\021\031\023\026. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \030\036\002\036\027\024\022 \021\ \026\022\032\036 \027\026\b\024\007\017\035\f\016 \023\024\007 )Tj 0.147 Tw T* (\027\026\002\035\033\007\036\027\017\036\n \007\036\021\f\022\024\020\024\ \b\017\030\031\030\020\026 \017)Tj /Span<>> BDC ( )Tj EMC (\020\026\f\021\030\024\220\027\021\036\030\024\035\024\020\026. )Tj 0.175 Tw 0 -1.218 TD (\225)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\026 3 \035\036\021 \031)Tj /Span<>> BDC ( )Tj EMC (\030\036\002\036\027\022\026 \f\021\026\035\024 \024\021\n\036\004\026\021\ \034\f\016 \022\026\035\024)Tj 0 Tw (-)Tj 0.164 Tw 0 -1.218 TD [(\n\026\026\027\017\036, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 )0.5(\022\024\021\024\030\024\020\024 \024\027\026 )0.5(\027\036\024\007\027\024\022\030\026\021\027\024 )0.5(\020\024)]TJ 0 Tw (-)Tj 0.126 Tw T* [(\f\023\017\021\026\035\017\017\030\024\r\026\035\026\f\034 )0.5(\007\035\016 \024\002\f\035\036\007\024\r\026\027\017\016 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 )Tj 0.318 Tw T* (\022\024\027\f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\ \017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\035\036\007\024\r\026\027\017\017 \002\t\035\026 )Tj 0.074 Tw T* (\007\017\026\020\027\024\f\021\017\030\024\r\026\027\026 \027\036\007\024\ \f\021\026\021\024\004\027\024\f\021\034 \026\027\031\f\026 III \f\021\036\ \023\036\027\017, )Tj 0.042 Tw T* (\027\036\007\036\030\032\026\027\017\036 \022\026\035\026. \200)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 9 \035\036\021 \004\026\f\021\024\021\026 \220\ \023\017\024\007\024\r )Tj 0.268 Tw 0 -1.218 TD (\027\036\007\036\030\032\026\027\017\016 \022\026\035\026 \031\r\036\035\ \017\004\017\035\026\f\034, \r\024\027\017\022\035\026 \023\030\024\002\ \035\036\n\026 )Tj 0.433 Tw 0 -1.218 TD (\f\024\006\017\026\035\017\026\006\017\017 \030\036\002\036\027\022\026\ : \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\036\013\036\027\017\017 \002\026\f\f\036\005\027\026 )Tj 0.034 Tw 0 -1.218 TD (\030\036\002\036\027\024\022 \024\021\n\036\004\026\035 \024\013\031\013\ \036\027\017\036 \253\026\021\036\022\026\027\017\016\273 \r\024\007\t \ \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016)Tj 0 Tw (-)Tj 0.181 Tw T* [(\n\031\033 )0.5(\022\017\001\022\031. )0.6(\025\024\n\023\035\036\022\f\027\024\036 )0.5(\024\002\f\035\036\007\024\r\026\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 18.345 0 Td (\031\f\035\024\r\017\016\b )Tj 0.323 Tw -18.345 -1.218 Td [(\230\035\034\017\027\f\022\024\005 \002\024\035\034\027\017\006\t )0.5(\023\024\r\024\035\017\035\024 \r\t\016\r\017\021\034 \027\036\f\024\f\021\ \024)]TJ 0 Tw (-)Tj 0.111 Tw T* [(\016\021\036\035\034\027\024\f\021\034 )0.5(\023\036\030\036\007\027\036\005 )0.5(\023\024\030\006\017\017 )0.5(\203\202\225, \r)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\016\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\004\036\n )0.5(\030\036)]TJ 0 Tw (-)Tj 0.021 Tw T* (\002\036\027\022\031 \002\t\035\026 \r\t\023\024\035\027\036\027\026 \024\ \023\036\030\026\006\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\027\024\005 \r\t\001\036 )Tj 0 Tw T* (\n\036\021\024\007\017\022\036.)Tj 0.01 Tc 0.471 Tw T* (\200\030\036\n\016 \024\023\036\030\026\006\017\017 \f\024\f\021\026\r\017\ \035\024 64 \n\017\027\031\021\t, \017\027\021\030\026\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.416 Tw T* [(\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\ \005 \027\036 \024\021\n\036\004\026\035\024\f\034. \215\024\f\035\036)10( )]TJ ET q 70.866 198.17 416.693 247.222 re W n q /GS0 gs 416.6928888 0 0 247.231385 70.8661785 198.160952 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 0.041 Tw 9 0 0 9 70.8662 187.3701 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \207\027\007\035\033\037\031\036\023\021\034\036\034\016 \022\031\034\025\ \033\037\003\016\020\022\016 \020\022\031\036\016\005\016\020\020\034\t \ \021\022\004\021\022. 1)Tj /Span<>> BDC ( )Tj EMC (\227 \023)Tj /Span<>> BDC ( )Tj EMC (\033\016\025\016\020\021\037 \020\037)Tj /Span<>> BDC ( )Tj EMC (\005\034\034\f\016\033\037\006\022\034\020\020\034\b \220\035\037\f\016,\ 2)Tj /Span<>> BDC ( )Tj EMC (\227 \f\033\022)Tj /Span<>> BDC ( )Tj EMC (\021\034\020\035)Tj 0 Tw (-)Tj -0.021 Tw 0 -1.2 TD [(\033\034\027\016 )0.6(\n\016\033\016\031 )0.6(2 )0.6(\013\034\005\037 )0.6(\f\034\024\027\016 )0.6(\f\034\036\035\034\033\020\034\t )0.6(\033\016\021\034\020\024\035\033\023\021\035\022\036\020\034\t )0.7(\034\f\016\033\037\006\022\022, )0.6(3)]TJ /Span<>> BDC ( )Tj EMC 27.881 0 Td [(\227 )0.6(\f\033\034\025\037 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 4.457 0 Td [(\036\034\027\016\036\032\b )0.5(\024\034\021\033\037\217\016\020\022\016\b )0.6(\023)]TJ /Span<>> BDC ( )Tj EMC 10.086 0 Td [(\033\016\025\016\020\021\037 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 4.112 0 Td (\037\020\037\027\007\020\034\t )Tj 0.02 Tw -46.536 -1.2 Td (\022\020\021\034\020\035\022\020\016\020\006\022\016\t \f\034\024\027\016\ \037\035\033\016\031\022\022 \037\020\023\024\037, \005\034)Tj /Span<>> BDC ( )Tj EMC (\033\016\021\034\020\024\035\033\023\021\006\022\022, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \f\033\034\025\037 \024)Tj /Span<>> BDC ( )Tj EMC (\036\034\027\016\036\032\b \024\034\021\033\037\217\016\020\022\016\b \f\ \033\022)Tj /Span<>> BDC ( )Tj EMC (\021\034\020\035\033\034\027\016 \n\016\033\016\031 2 \013\034\005\037 )Tj -0.034 Tw T* (\f\034\024\027\016 \f\034\036\035\034\033\020\034\t \033\016\021\034\020\ \024\035\033\023\021\035\022\036\020\034\t \034\f\016\033\037\006\022\022\ : A)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\007\035\033\037\031\036\023\021\034\036\037\030 \005\027\022\ \020\037 \037\020\037\027\007\020\034\013\034 \021\037\020\037\027\037, \ B)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\007\035\033\037\031\036\023\021\034\036\037\030 \004\022\033\ \022)Tj 0 Tw (-)Tj 0.019 Tw T* (\020\037 \037\b\f\023\027\032 \f\033\030\b\034\t \021\022\004\021\022, C\ )Tj /Span<>> BDC ( )Tj EMC [(\227 \020\037\033\023\003\020\032\t \037\020\037\027\007\020\032\t )0.5(\024\017\022\020\021\035\016\033, D)]TJ /Span<>> BDC ( )Tj EMC (\227 \031\034\020\037 \020\037\033\023\004\016\020\022\030 \020\034\033\b\ \037\027\007\020\034\t \024\035\033\023\021\035\023\033\032 \025\016\031\ \036\022\031\023\037\027\022)Tj 0 Tw (-)Tj T* (\031\037\006\022\022 \024\035\016\020\021\022 \020\022\031\036\016\005\016\ \020\020\034\t \021\022\004\021\022 \022)Tj /Span<>> BDC ( )Tj EMC [(\f\016\033\016\005\020\016\t \f\034\033\006\022\022 \037\020\037\027\007\ \020\034\013\034 \024\017\022\020\021\035\016)0.6(\033\037)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.029 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Ultrasound imag)12(e of)]TJ /Span<>> BDC ( )Tj EMC [(the pull-throw)12.1(ed rectum 1)]TJ /Span<>> BDC ( )Tj EMC (\227 in a)Tj /Span<>> BDC ( )Tj EMC (child before reconstruction of)Tj /Span<>> BDC ( )Tj EMC [(the e)-15(xter)-14(nal anal sphincter)61(, 2)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj -0.024 Tw T* (the)Tj /Span<>> BDC ( )Tj EMC [(same child 2 years af)-46(ter repeated reconstructiv)13(e surg)12(er)-43(y)42(, 3)]TJ /Span<>> BDC ( )Tj EMC [(\227 v)13(olitional contraction test in a)]TJ /Span<>> BDC ( )Tj EMC [(child with anal incontinence af)-46(ter )]TJ -0.014 Tw T* [(anal )0.5(atresia, )0.5(before )0.6(anal )0.5(sphincter )0.5(reconstruction, )0.5(4)]TJ /Span<>> BDC ( )Tj EMC 20.227 0 Td [(\227 )0.5(v)13(olitional )0.5(contraction )0.5(test )0.5(2 years )0.5(af)-46(ter repeat reconstructiv)13(e )0.5(surg)12(er)-43(y)12(: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 29.166 0 Td (\227 )Tj 0.008 Tw -49.394 -1.2 Td (ultrasound length of)Tj /Span<>> BDC ( )Tj EMC (the anal canal, B)Tj /Span<>> BDC ( )Tj EMC (\227 ultrasound width of)Tj /Span<>> BDC ( )Tj EMC [(the rectal am)16(pulla, C)]TJ /Span<>> BDC ( )Tj EMC [(\227 e)-15(xter)-14(nal anal sphincter)61(, D)]TJ /Span<>> BDC ( )Tj EMC (\227 zone of)Tj /Span<>> BDC ( )Tj EMC (viola)Tj 0 Tw (-)Tj T* [(tion nor)-13.9(mal structure without visualization of)]TJ /Span<>> BDC ( )Tj EMC [(the rectal w)13.4(all and the)]TJ /Span<>> BDC ( )Tj EMC [(anter)-36.8(ior por)-40(tion of)]TJ /Span<>> BDC ( )Tj EMC (the anal sphincter)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\037\035\030\202\030\206\021\207\037\030\021 \202\006\214\035\003)15(\200\021\202\030\027)]TJ 54.711 0 Td [(C)10(A)20(SE REPORT)]TJ -54.711 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)69(4, \023\0221)69(, 202)23(5)]TJ 43.082 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)69(4, \023\0221)69(, 202)23(5)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (86)Tj ET endstream endobj 633 0 obj <>stream ÿØÿîAdobedÿÛ '$''''$25552;;;;;;;;;; %%#(((((#,0000,7;;;7;;;;;;;;;; %%#(((((#,0000,7;;;7;;;;;;;;;; %%#(((((#,0000,7;;;7;;;;;;;;;;ÿÝ7ÿÀe""ÿÄ¢ s!1AQ"aq2¡±#BR‘crÁÑ$34STbds‚’“²Òñ %&'()*56789:CDEFGHIJUVWXYZefghijtuvwxyzƒ„…†‡ˆ‰Š”•–—˜™š¢£¤¥¦§¨©ª³´µ¶·¸¹ºÂÃÄÅÆÇÈÉÊÓÔÕÖ×ØÙÚáâãäåæçèéêðòóôõö÷øùúw!1AQaq‘ð"¡±Á2BRÑáñ#$Ss‚3Cb’¢ 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