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L)35(eiomyosar)-32(coma )]TJ 0.008 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he esopha)-17(gus. )]TJ /T1_1 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Thoracic and Cardiov)16.1(ascular Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1978;75\(5\):740\226746. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1046/j.1442-2050.2003.00298.x)Tj 0 0 0 1 k /GS1 gs 0.333 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(W, S)-16(hao)]TJ /Span<>> BDC ( )Tj EMC (M, Hu)Tj /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he dia)-17(gnost)-32(ic v)-15(al)35(ue of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(o)]TJ 0 Tw (-)Tj 0.224 Tw -1.796 -1.25 Td [(scopic ul)56(tr)-33(asound for esopha)-17(geal subepi)-24(t)-13(hel)-30.9(ial lesions: A)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf 0.019 Tc 0.699 Tw T* (Medicine \(Baltimore\))Tj /T1_0 1 Tf [(. 2024;103\(46\):e40419. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.019 Tw (10.1097/)Tj 0 Tc 0 Tw T* (MD.0000000000040419)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ebi)Tj /Span<>> BDC ( )Tj EMC 1.601 0 Td [(M, )0.5(Sak)-16.9(amo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 5.423 0 Td [(K, )0.6(Inoue)]TJ /Span<>> BDC ( )Tj EMC 3.76 0 Td [(S, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.158 0 Td [(al. )0.6(Esopha)-17(geal )0.6(L)35(eiomyosar)-32(coma )]TJ 0.024 Tc 0.878 Tw -14.738 -1.25 Td [(Dia)-17.4(gnosed b)11.6(y End)-16.4(oscopic Ul)55.6(tr)-33.4(asound-guided F)-19.4(ine-needle)24( )]TJ 0 Tc 0.184 Tw T* [(Aspir)-33(a)15.1(t)-32(ion Biopsy and Cur)-23.9(ed wi)-24(t)-13(h Sur)-31.9(gical R)13(esec)-16(t)-32(ion. )]TJ /T1_1 1 Tf [(Inter)-14(n Med)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2019;58\(17\):2479\2262483. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.2169/inter)-15(nalmedic)-23.9(ine.2219-18)]TJ 0 0 0 1 k /GS1 gs 0.171 Tw T* (41.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Mekr)-33(as)]TJ /Span<>> BDC ( )Tj EMC [(A, Kr)-24(enn)]TJ /Span<>> BDC ( )Tj EMC [(V, P)30(er)-24(r)-32.9(ak)-16(is)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gastr)-31.9(ointest)-32(inal schw)-12(an)]TJ 0 Tw (-)Tj 0.225 Tw -1.796 -1.25 Td (nomas: a)Tj /Span<>> BDC ( )Tj EMC [(r)-32.9(ar)-24(e but im)10(por)-21.9(t)15(ant dif)-56(fer)-23.9(ent)-32(ial dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC (mesenchy)Tj 0 Tw 27.286 0 Td (-)Tj 0.342 Tw -27.286 -1.25 Td [(mal tumor)-9.9(s of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-32(ointest)-31.9(inal tr)-33(a)-17(c)-16(t. )]TJ /T1_1 1 Tf 16.678 0 Td (BMC Surg)Tj /T1_0 1 Tf (. 2018;18\(1\):47. )Tj 0 Tw 12.377 73.75 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1186/s12893-018-0379-2)Tj 0 0 0 1 k /GS1 gs 0.018 Tw -1.847 -1.25 Td (42.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hu)Tj /Span<>> BDC ( )Tj EMC [(J, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC (X, Ge)Tj /Span<>> BDC ( )Tj EMC [(N, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-32.9(asound and end)-15.9(o)]TJ 0 Tw (-)Tj 0.019 Tw -1.796 -1.25 Td [(scopic r)-24(esec)-16(t)-31.9(ion for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-37(ic schw)-12(annoma. )]TJ /T1_1 1 Tf 0 Tw (Medicine)Tj /T1_0 1 Tf (. )Tj 0.023 Tw T* [(2017;96\(25\):e7175. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MD.0000000000007175)Tj 0 0 0 1 k /GS1 gs 0.312 Tw T* (43.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)40(ar)-24(k)]TJ /Span<>> BDC ( )Tj EMC (SH, Kim)Tj /Span<>> BDC ( )Tj EMC [(GH, P)40(ar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(DY, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-15.9(osono)-16(gr)-33(aphic f)-28(indings )]TJ 0.095 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.143 0 Td [(gastr)-37(ic )0.5(ec)-16(t)17.1(opic )0.5(p)32(ancr)-24(eas: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 11.452 0 Td [(single )0.5(center )0.5(e)-18(xper)-36.9(ience. )]TJ /T1_1 1 Tf 10.667 0 Td [(J )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 1.889 0 Td (Gastro )Tj 0.02 Tc 0.718 Tw -25.151 -1.25 Td (and Hepatol)Tj /T1_0 1 Tf [(. 2011;26\(9\):1441\2261446. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.02 Tw (10.1111/j.1440-)Tj 0 Tc 0 Tw T* (1746.2011.06764.x)Tj 0 0 0 1 k /GS1 gs 0.006 Tw T* (44.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)11(ong)]TJ /Span<>> BDC ( )Tj EMC 2.273 0 Td [(L, )0.5(Kid)42.1(a)]TJ /Span<>> BDC ( )Tj EMC 2.824 0 Td [(M, )0.6(Y)49.9(amauchi)]TJ /Span<>> BDC ( )Tj EMC 5.16 0 Td [(H, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC 2.104 0 Td [(al. )0.6(F)20(a)-17(c)-16(t)17(or)-10(s )0.5(af)-56(fec)-15.9(t)-32(ing )0.5(t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC 9.962 0 Td [(dia)-17(gnos)]TJ 0 Tw (-)Tj -0.021 Tw -24.119 -1.25 Td [(t)-32(ic a)-17(ccur)-32.9(a)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-33(asono)-16(gr)-32.9(aphy)]TJ /Span<>> BDC (-)Tj EMC [(guided f)-28(ine)]TJ /Span<>> BDC (-)Tj EMC (needle aspi)Tj 0 Tw (-)Tj 0.107 Tw T* [(r)-33(a)15(t)-32(ion \(EUS)]TJ /Span<>> BDC (-)Tj EMC [(FN)13.1(A\) for upper gastr)-32(ointest)-31.9(inal submucosal or e)-18(xtr)-32.9(al)34.9(u)]TJ 0 Tw (-)Tj 0.066 Tw T* [(minal sol)-31(id mass lesions. )]TJ /T1_1 1 Tf [(Dig)12.1(estiv)13(e Endoscop)12(y)]TJ /T1_0 1 Tf (. 2012;24\(5\):358\226363. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1443-1661.2012.01243.x)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.374 Tw -1.847 -1.25 Td (45.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(MK. End)-16(oscopic Ul)56(tr)-33(asound in Gastr)-31.9(oenter)-32(op)32(ancr)-24(ea)15(t)-32(ic)10( )]TJ 0 Tc -0.068 Tw -1.836 -1.25 Td [(Neur)-32(oend)-15.9(o)-16(cr)-37(ine T)60(umor)-10(s. )]TJ /T1_1 1 Tf [(Gut Liv)13(er)]TJ /T1_0 1 Tf [(. 2012;6\(4\):405\226410. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5009/)Tj T* (gnl.2012.6.4.405)Tj 0 0 0 1 k /GS1 gs -0.049 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(McL)35(ean)]TJ /Span<>> BDC ( )Tj EMC [(AM, F)20(air)-32(cl)30.1(ough)]TJ /Span<>> BDC ( )Tj EMC [(PD. End)-16(oscopic ul)56.1(tr)-33(asound in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(l)30.1(o)-16(cal)-31(isa)]TJ 0 Tw (-)Tj 0.008 Tw -1.796 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ancr)-24(ea)15(t)-32(ic isle)-12(t cell tumour)-9.9(s. )]TJ /T1_1 1 Tf [(Best Practice & R)21(esearch Clinical )]TJ 0.195 Tw T* [(Endocr)-36.9(inology & Metabolis)33.1(m)]TJ /T1_0 1 Tf [(. 2005;19\(2\):177\226193. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (beem.2004.11.012)Tj 0 0 0 1 k /GS1 gs 0.272 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(int)17.1(o-P)40(ais)]TJ /Span<>> BDC ( )Tj EMC [(T, F)10(er)-15(nandes)]TJ /Span<>> BDC ( )Tj EMC [(S, P)35(r)-32(oen\347a)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(L)-31.9(ar)-32(ge Gastr)-37(ic )]TJ 0.026 Tw -1.796 -1.25 Td [(Infl)-15.9(amma)15(t)17(or)-24(y F)-19(ibr)-32(oid P)10(ol)35(yp. )]TJ /T1_1 1 Tf [(GE P)15(or)-39.9(t J Gastroenterol)]TJ /T1_0 1 Tf (. 2015;22\(2\):61\226)Tj 0.023 Tw T* [(64. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.jpge.2014.07.006)Tj 0 0 0 1 k /GS1 gs 0.321 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\207\036\035\034\n\036\030)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \025\024\f\021\t\030\022\024)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \215\030\017\r\024\030\024\021\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\205., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.238 Tw -1.796 -1.25 Td (\202\002\036\030\030\026\027\021\027\026\016 \023\024\007\032\036\035\031\ \007\024\004\027\026\016 \032\036\035\036\026 \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\036\005. )Tj /T1_1 1 Tf (\211\031\033\032\031\024\013 \030\027\023\024\n\031\235 )Tj 0 Tw T* (\030\022\027\023\031\f\031\b\022\022)Tj /T1_0 1 Tf 0.069 Tw [(. 2013;11\(3\):49\22654. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.20953/1727-5784-2013-3-)Tj T* (49-54)Tj 0 0 0 1 k /GS1 gs -0.002 Tw ( / Belmer)Tj /Span<>> BDC ( )Tj EMC [(S)-13(V, K)25(ost)-10(yr)-23.9(ko)]TJ /Span<>> BDC ( )Tj EMC [(EV, P)35(r)-36.9(i)-16(vor)-32(o)17(tsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(VF, L)35(uppov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(NE. A)-14(ber)-23.9(r)-33(ant )]TJ 0.01 Tw T* [(p)32(ancr)-24(eas )0.6(in )0.5(childr)-23.9(en. )]TJ /T1_1 1 Tf 8.687 0 Td [(Issues )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 3.672 0 Td [(pediatr)-36.9(ic )0.5(dietetics.)]TJ /T1_0 1 Tf [( )0.6(2013;11\(3\):49\22654. )]TJ 0.023 Tw -12.359 -1.25 Td [(\(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.20953/1727-5784-2013-3-49-54)Tj 0 0 0 1 k /GS1 gs 0.272 Tw T* (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)30(t)-30(t)-32(well)]TJ /Span<>> BDC ( )Tj EMC (A, Sams)Tj /Span<>> BDC ( )Tj EMC [(S, F)10(uk)-17(ami)]TJ /Span<>> BDC ( )Tj EMC [(N. Dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(ec)-16(t)17(opic p)32(ancr)-24(eas )]TJ 0.005 Tc 0.349 Tw -1.796 -1.25 Td [(b)12.2(y end)-15.8(oscopic ul)56.2(tr)-32.7(asound wi)-23.7(t)-12.8(h f)-27.8(ine-needle aspir)-32.8(a)15.3(t)-31.8(ion. )]TJ /T1_1 1 Tf [(W)29.2(orld J)5( )]TJ 0 Tc 0 Tw T* (Gastroenterol)Tj /T1_0 1 Tf -0.054 Tw [(. 2015;21\(8\):2367\2262373. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3748/wjg.v21.i8.2367)Tj 0 0 0 1 k /GS1 gs 0.319 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(ar)-33(a)-17(ca)]TJ /Span<>> BDC ( )Tj EMC [(C, T)60(ur)-15(ner)]TJ /Span<>> BDC ( )Tj EMC (BG, Cizginer)Tj /Span<>> BDC ( )Tj EMC [(S, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)-24.9(ccur)-33(a)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC (EUS in )Tj 0.015 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ev)-15(al)35(ua)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(s)26(mall gastr)-37(ic subepi)-23.9(t)-13(hel)-31(ial lesions. )]TJ /T1_1 1 Tf 0 Tw 21.416 0 Td (Gastrointestinal )Tj -21.416 -1.25 Td [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.023 Tw [(. 2010;71\(4\):722\226727. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2009.10.019)Tj 0 0 0 1 k /GS1 gs -0.112 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)13(ev)-16(ia)]TJ /Span<>> BDC ( )Tj EMC [(RA, S)-16(hah)]TJ /Span<>> BDC ( )Tj EMC [(R, Mand)42(al)-31(ia)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Esopha)-16.9(geal G)20(r)-32.9(anul)-16(ar Cell T)60(umor: )]TJ 0.001 Tc 0.349 Tw -1.796 -1.25 Td (An)Tj /Span<>> BDC ( )Tj EMC [(U)13.2(ncommon Cause of)]TJ /Span<>> BDC ( )Tj EMC [(Dy)-12.8(spha)-16.7(gia. )]TJ /T1_1 1 Tf -0.001 Tw (Cureus)Tj /T1_0 1 Tf 0.349 Tw [(. 2023;15\(7\):e41846.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.7759/cur)-23.9(eus.41846)]TJ 0 0 0 1 k /GS1 gs -0.001 Tw -1.847 -1.25 Td (52.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-20(yu)]TJ /Span<>> BDC ( )Tj EMC (DG, Kim)Tj /Span<>> BDC ( )Tj EMC (SJ, Choi)Tj /Span<>> BDC ( )Tj EMC [(CW, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Combina)15(t)-32(ion convent)-32(ional end)-16(os)]TJ 0 Tw (-)Tj 0.077 Tw -1.796 -1.25 Td [(copy and end)-16(oscopic ul)56.1(tr)-33(asound can dif)-56(fer)-23.9(ent)-32(ia)15(te be)-12(t)-32(ween esopha)]TJ 0 Tw (-)Tj 0.251 Tw T* [(geal gr)-33(anul)-15.9(ar cell tumor)-10(s and leiomyomas. )]TJ /T1_1 1 Tf (Medicine \(Baltimore\))Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2022;101\(45\):e31435. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/MD.0000000000031435)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.472 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (\212\r\024\030\026\022\024\r\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\230.\200., \202\030\017\220\035\034)Tj /Span<>> BDC ( )Tj EMC (\207.\204., \210\030\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0 Tc 0.212 Tw -1.847 -1.25 Td [(\003\036\030\027\017\f\021\024-\022\035\036\021\024\004\027\026\016 )0.7(\024\023\031\b\024\035\034 )0.6(\007\t\b\026\021\036\035\034\027\t\b )0.7(\023\031\021\036\005. )]TJ /T1_1 1 Tf 21.363 0 Td [(\003\032\200\022\021 )0.6(\033\020\023\031\f\031)]TJ 0 Tw (-)Tj -21.363 -1.25 Td (\b\022\022)Tj /T1_0 1 Tf 0.045 Tw [(. 75\(3\):34\22639. / Dvor)-33(akovsk)-16.9(aia)]TJ /Span<>> BDC ( )Tj EMC [(I.V., Ar)-37(i\351l\241 B.M., Or)-29.9(l)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.076 Tw T* [(Air)-38(w)-11.9(a)15(y gr)-33(anul)-16(ar cell tumor. )]TJ /T1_1 1 Tf [(R)22(ussian Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Archiv)13(e of)]TJ /Span<>> BDC ( )Tj EMC [(P)18(athology.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2013;75\(3\):34)Tj /Span<>> BDC (-)Tj EMC (39. \(In Russ.\))Tj 0.013 Tc 0.485 Tw T* (54.)Tj /Span<>> BDC ( )Tj EMC 1.849 0 Td [(L)-32.2(iu)]TJ /Span<>> BDC ( )Tj EMC [(R, A)14.8(dler)]TJ /Span<>> BDC ( )Tj EMC [(DG. Dupl)-31.2(ica)14.8(t)-32.2(ion cy)-13.2(sts: Dia)-17.2(gnosis, mana)-17.2(ge)]TJ 0 Tc 0 Tw (-)Tj 0.231 Tw -1.849 -1.25 Td [(ment, and t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-32.9(asound. )]TJ /T1_1 1 Tf (Endosc Ultrasound)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2014;3\(3\):152\226160. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4103/2303-9027.138783)Tj 0 0 0 1 k /GS1 gs 0.037 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(El)30(oubeidi)]TJ /Span<>> BDC ( )Tj EMC (MA, Cohn)Tj /Span<>> BDC ( )Tj EMC [(M, Cer)-24(fol)-30.9(io)]TJ /Span<>> BDC ( )Tj EMC [(RJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic ul)56(tr)-32.9(asound-)]TJ -0.023 Tw -1.796 -1.25 Td [(guided f)-28(ine-needle aspir)-33(a)15(t)-32(ion in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(for)-24(egut dupl)-31(ica)15(t)-32(ion )]TJ -0.008 Tw T* [(cy)-13(sts: T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(v)-15(al)35.1(ue of)]TJ /Span<>> BDC ( )Tj EMC [(demonstr)-32.9(a)15(t)-32(ing de)-12(t)15(a)-17(ched c)-24(il)-31(iar)-23.9(y tuf)-28(ts in cy)-13(st fl)35(uid. )]TJ /T1_1 1 Tf 0 Tw T* (Cancer)Tj /T1_0 1 Tf 0.023 Tw [(. 2004;102\(4\):253\226258. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cncr.20369)Tj 0 0 0 1 k /GS1 gs 0.258 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)12(ahi)]TJ /Span<>> BDC ( )Tj EMC (JE, Safdie)Tj /Span<>> BDC ( )Tj EMC [(FM. 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Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.124 Tw 10 0 0 10 42.5197 724.8299 Tm (\222\021\026\030\004\036\027\022\024\r \212\036\027\017\f \212\n\017\021\ \030\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw 0 -1.218 TD (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0003-3726-8246)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Mikhail S. Bur)-23.9(d)17(yukov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4690-9335)Tj 0 -1.218 TD [(Nair)-33(a A. Ha)15.1(yr)-33(ape)-11.9(t)-10(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7295-8037)Tj 0 -1.218 TD [(Ild)42(ar R. V)25.1(al)-31(iul)-31(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-6110-8941)Tj T* [(Ale)-18(x)12(e)-10.9(y A. Gvozdev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3096-2070)Tj T* [(G)20(r)-37(igor)-23.9(y A. K)25(or)-32(olev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5730-3684)Tj T* [(Ox)-11(ana V. P)40.1(akl)-31(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6373-1888)Tj 23.244 12.178 Td [(V)25(aler)-37(i)-16(ia I. R)-19.9(y)22(ab)16(tsev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3174-7695)Tj T* [(Na)15(t)15(al)-31(ia V. A)-24.9(ge)-11(yk)-15.9(ina)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8726-0929)Tj T* [(Ev)-21(genia V. Gusev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0009-3782-8366)Tj T* [(Il)-31(ia I. Iv)-14.9(anov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0002-8492-2856)Tj T* [(Ir)-37(ina Y)35.1(u. K)25(or)-24(zhev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-5984-5660)Tj T* [(Mak)-10(sim M. L)35.1(okhma)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-8305-7592)Tj 0 -1.218 TD [(T)40(a)15(t)-32(iana V. 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A)Tj /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-23.9(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(sym)10(p)]TJ 0 Tw (-)Tj 0.004 Tw -1.296 -1.25 Td [(t)17(oma)15(t)-32(ic s)26(mall bo)-14(wel l)-30.9(ipomas of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he jejunum and ileum. )]TJ /T1_4 1 Tf (Ann Med Surg )Tj 0 Tw T* (\(Lond\))Tj /T1_1 1 Tf 0.023 Tw [(. 2020;58:52\22667. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.amsu.2020.08.028)Tj 0 0 0 1 k /GS1 gs 0.007 Tc 0.349 Tw T* [(5)0.5(.)]TJ /Span<>> BDC 0.809 0 Td ( )Tj EMC 0.506 0 Td [(B)0.5(l)-15.4(a)0.5(n)0.5(c)0.5(h)0.6(e)-11.5(t)]TJ /Span<>> BDC 3.642 0 Td ( )Tj EMC [(M)0.6(C)0.5(,)0.5( A)0.5(r)-14.5(n)0.6(a)0.5(l)]TJ /Span<>> BDC 4.674 0 Td ( )Tj EMC [(E)0.6(,)0.5( P)40.5(a)0.5(p)32.5(a)0.6(r)-23.5(e)0.5(l)]TJ /Span<>> BDC 4.836 0 Td ( )Tj EMC [(P)0.6(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 2.731 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( O)0.5(b)0.5(s)0.6(t)0.5(r)-21.5(u)0.6(c)-15.5(t)-31.5(i)-15.4(v)0.5(e)0.5( d)0.5(u)0.5(o)0.6(d)0.5(e)]TJ 0 Tc 0 Tw 10.088 0 Td (-)Tj 0.013 Tc 0.485 Tw -27.286 -1.25 Td [(nal l)-31.2(ipoma successfull)34.8(y tr)-24.2(ea)14.7(ted b)11.8(y end)-16.2(oscopic pol)34.8(ypec)-16.2(t)16.8(omy.)13( )]TJ /T1_4 1 Tf 0.01 Tc 0.371 Tw T* [(Gastrointestinal Endoscop)12.1(y)]TJ /T1_1 1 Tf [(. 2003;58\(6\):938\226939. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw (10.1016/)Tj 0 Tc 0 Tw T* (S0016-5107\(03\)02232-6)Tj 0 0 0 1 k /GS1 gs 0.333 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(a)15(t)17(os)]TJ /Span<>> BDC ( )Tj EMC [(W, K)-16(a)10(wczyk-Kr)-21.9(upk)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(A, S)15(tr)-24(zel)16(czyk)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Benign and )Tj 0.012 Tc 0.438 Tw -1.296 -1.25 Td [(non-neopl)-15.8(ast)-31.9(ic tumour)-9.9(s of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.8(he duodenum. )]TJ /T1_4 1 Tf [(Pr)-15.8(z Gastroenterol)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2019;14\(4\):233\226241. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5114/pg.2019.90250)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.451 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.333 0 Td (Kim)Tj /Span<>> BDC ( )Tj EMC [(JH, Y)39.8(o)-16.2(on)]TJ /Span<>> BDC ( )Tj EMC (HH, Jeong)Tj /Span<>> BDC ( )Tj EMC [(SH, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Spont)14.8(aneous peeled)12( )]TJ 0.015 Tc 0.531 Tw -1.333 -1.25 Td [(i)0.5(l)0.5(e)0.5(a)0.5(l)0.5( )0.5(g)0.5(i)0.5(a)0.5(nt)0.6( l)-30.5(i)0.5(p)0.5(o)0.5(m)0.5(a)0.5( )0.5(c)0.5(a)0.5(u)0.5(s)0.5(e)0.5(d)0.5( b)12.5(y)0.5( )0.5(l)30.5(o)-13.5(w)0.5(e)0.5(r)0.5( g)0.5(a)0.5(s)0.5(t)0.5(r)-31.5(o)0.5(i)0.5(n)0.5(t)0.5(e)0.5(s)0.5(t)-31.4(i)0.5(na)0.5(l)0.6( b)0.5(l)0.5(e)0.5(e)0.5(d)]TJ 0 Tc 0 Tw 27.286 0 Td (-)Tj 0.013 Tc -0.013 Tw -27.286 -1.25 Td [(i)0.5(n)0.5(g)0.5(.)0.5( )]TJ /T1_4 1 Tf 0.461 Tw 2.35 0 Td [(M)0.5(e)0.5(d)0.5(i)0.5(c)0.5(i)0.5(n)0.5(e)0.5( )0.6(\()0.5(B)0.5(a)0.5(l)0.5(t)0.5(i)0.5(m)0.5(o)0.5(r)0.5(e)0.5(\))]TJ /T1_1 1 Tf 9.057 0 Td [(.)0.5( )0.5(2)0.5(0)0.5(1)0.5(7)0.5(;)0.5(9)0.5(6)0.5(\()0.5(5)0.5(1)0.5(\))0.5(:)0.5(e)0.5(9)0.5(2)0.5(5)0.5(3)0.5(.)0.5( )0.5(d)-15.5(o)0.5(i)0.5(:)]TJ /Span<>> BDC 11.697 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw 0.706 0 Td [(1)0.5(0)0.5(.)0.5(1)0.5(0)0.5(9)0.5(7)0.5(/)]TJ 0 Tc 0 Tw -23.811 -1.25 Td (MD.0000000000009253)Tj 0 0 0 1 k /GS1 gs 0.004 Tc 0.349 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.308 0 Td [(W)12.1(ang)]TJ /Span<>> BDC ( )Tj EMC (CY, Hsu)Tj /Span<>> BDC ( )Tj EMC [(HS, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(Y)32.1(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Intr)-32.9(amur)-32.9(al L)-31.9(ipoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he)4( )]TJ 0 Tc 0 Tw -1.308 -1.25 Td [(Esopha)-17(gus. )]TJ /T1_4 1 Tf 0.178 Tw 4.987 0 Td (J Chin Med Assoc)Tj /T1_1 1 Tf [(. 2005;68\(5\):240\226243. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj -4.987 -1.25 Td (S1726-4901\(09\)70216-3)Tj 0 0 0 1 k /GS1 gs 0.163 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)20(aul)-32(x)]TJ /Span<>> BDC ( )Tj EMC [(AL, K)25(o)17(t)-12.9(har)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(S, A)-25(cost)15(a)]TJ /Span<>> BDC ( )Tj EMC [(RD, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopy in )]TJ 0.276 Tw -1.296 -1.25 Td [(subepi)-24(t)-12.9(hel)-31(ial )0.6(lesions )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 10.463 0 Td [(t)-13(he )0.6(GI )0.5(tr)-33(a)-16.9(c)-16(t. )]TJ /T1_4 1 Tf 6.068 0 Td [(Gastrointestinal )0.7(Endoscop)12(y)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw -16.532 -1.25 Td [(2017;85\(6\):1117\2261132. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.gie.2017.02.022)Tj 0 0 0 1 k /GS1 gs 0.049 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(er)-16(mos)]TJ /Span<>> BDC ( )Tj EMC [(S, R)13(esl)-16(an)]TJ /Span<>> BDC ( )Tj EMC [(O, Al)25(qabandi)]TJ /Span<>> BDC ( )Tj EMC [(O, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Giant gastr)-36.9(ic l)-31(ipoma p)25(r)-24(e)]TJ 0 Tw (-)Tj 0.085 Tw -1.796 -1.25 Td [(sent)-32(ing as GI bleed: Enuclea)15(t)-32(ion or R)13(esec)-16(t)-31.9(ion? )]TJ /T1_4 1 Tf [(Int J Surg Case R)20.9(ep)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2017;41:39\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijscr.2017.10.004)Tj 0 0 0 1 k /GS1 gs 0.026 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Amundson)Tj /Span<>> BDC ( )Tj EMC [(JR, S)15(tr)-32.9(aus)]TJ /Span<>> BDC ( )Tj EMC [(D, A)-23.9(zab)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Giant sym)10(pt)17(oma)15(t)-31.9(ic gastr)-37(ic )]TJ 0.192 Tw -1.796 -1.25 Td [(l)-31(ipoma: A)]TJ /Span<>> BDC ( )Tj EMC [(case r)-24(epor)-22(t and l)-31(i)-24(ter)-32.9(a)15(tur)-24(e r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Int J Surg Case R)21(ep)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2018;51:313\226317. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijscr.2018.08.061)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.615 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.864 0 Td (\025\026\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \204\026\021\r\017\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\203.\202., \206\026\035\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\003.\200., \017)Tj /Span<>> BDC ( )Tj EMC 23.14 0 Td [(\f\024\026\r\021.)17( )]TJ 0 Tc 0.065 Tw -25.003 -1.25 Td (\233\027\007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\ \036\027\017\036 \017\027\021\036\f\021\017\027\026\035\034\027\024\005 \ \035\017\023\024\n\t \002\024\035\034\001\017\b \030\026)Tj 0 Tw (-)Tj T* (\n\036\030\024\r. )Tj /T1_4 1 Tf 0.301 Tw 3.344 0 Td (\220\031\n\020\016\020\023\027\f\017\025\020\t \b\020\024\023\032\031\204\ \025\023\027\032\031\f\031\b\022\t)Tj /T1_1 1 Tf (. 2018;7\(2\):70\22679. / )Tj 0.264 Tw -3.344 -1.25 Td [(K)-16(ashin)]TJ /Span<>> BDC ( )Tj EMC 3.199 0 Td [(S.V., )0.6(Ma)15(t)-24(v)-16(ienko)]TJ /Span<>> BDC ( )Tj EMC 6.896 0 Td [(N.A., )0.6(Galkov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC 6.041 0 Td [(Z.V., )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.545 0 Td [(al. )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.411 0 Td [(end)-16(oscopic )]TJ -0.035 Tw -23.092 -1.25 Td [(r)-24(emov)-14.9(al of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(l)-16(ar)-32(ge-size intest)-32(inal l)-31(ipoma. )]TJ /T1_4 1 Tf [(R)22(ussian Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC (Evidence-)Tj 0.018 Tw T* (Based Gastroenterology. )Tj /T1_1 1 Tf (2018;7\(2\):70)Tj /Span<>> BDC (-)Tj EMC [(79. \(In Russ.\). d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17116/)Tj T* [(d)-16(okgastr)-31.9(o20187270)]TJ 0 0 0 1 k /GS1 gs 0.189 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(er)-24(r)-33(ar)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC 3.085 0 Td [(D, )0.5(Ber)-15(nar)-23.9(di)]TJ /Span<>> BDC ( )Tj EMC [(D, )0.5(S)-16(iboni)]TJ /Span<>> BDC ( )Tj EMC 9.167 0 Td [(S, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.322 0 Td [(al. )0.5(Esopha)-17(geal )0.5(L)-31.9(ipoma )0.5(and )]TJ 0.143 Tw -16.37 -1.25 Td [(L)-32(iposar)-32(coma: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew. )]TJ /T1_4 1 Tf [(W)29(orld J Surg)]TJ /T1_1 1 Tf (. 2021;45\(1\):225\226)Tj 0.023 Tw T* [(234. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00268-020-05789-4)Tj 0 0 0 1 k /GS1 gs 0.131 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(S, K)25(umar)]TJ /Span<>> BDC ( )Tj EMC [(A, Da)15(y)22(al)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Gastr)-36.9(ic l)-31(ipoma: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(ar)-24(e cause )]TJ 0.09 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(massi)-15.9(ve haema)15(temesis. )]TJ /T1_4 1 Tf [(Ann R Coll Surg Eng)13(l)]TJ /T1_1 1 Tf (. 2021;103\(6\):e196\226)Tj 0.023 Tw T* [(e198. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1308/r)-32(csann.2020.7094)]TJ 0 0 0 1 k /GS1 gs 0.157 Tw 29.055 58.75 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(o)-14(wler)]TJ /Span<>> BDC ( )Tj EMC [(DL, Whi)-24(te)]TJ /Span<>> BDC ( )Tj EMC [(SA. L)-32(ap)32(ar)-32(oscopic R)13(esec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC (Submucosal )Tj 0.055 Tw -1.796 -1.25 Td [(Gastr)-36.9(ic L)-32(ipoma: A)]TJ /Span<>> BDC ( )Tj EMC [(Case R)13(epor)-22(t. )]TJ /T1_4 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Laparoendoscopic Surg)12(er)-43(y)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1991;1\(5\):303\226306. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1089/lps.1991.1.303)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.468 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td [(K)-15.7(ad)42.3(aba)]TJ /Span<>> BDC ( )Tj EMC [(R, Bo)-13.7(wer)-9.7(s)]TJ /Span<>> BDC ( )Tj EMC [(KA, W)-15.6(ijesur)-36.7(iy)22.2(a)]TJ /Span<>> BDC ( )Tj EMC [(N, e)-11.7(t)]TJ /Span<>> BDC ( )Tj EMC (al. An)Tj /Span<>> BDC ( )Tj EMC [(U)13.3(nusual)13( )]TJ 0 Tc 0.341 Tw -1.847 -1.25 Td (Cause of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-32(ointest)-32(inal Bleeding: Duodenal L)-32(ipoma. )]TJ /T1_4 1 Tf [(Case R)21(ep )]TJ 0 Tw T* (Gastroenterol)Tj /T1_1 1 Tf 0.023 Tw [(. 2011;5\(1\):183\226188. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000327219)Tj 0 0 0 1 k /GS1 gs 0.23 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M\241r)-33(abe)-12(t S, Jar)-24(r)-32.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(MS, Akk)-16.9(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(I, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Col)30(onic intussuscept)-32(ion )]TJ 0.156 Tw -1.796 -1.25 Td [(caused b)12(y a)]TJ /Span<>> BDC ( )Tj EMC [(sigmoid)42(al l)-31(ipoma: A)]TJ /Span<>> BDC ( )Tj EMC [(case r)-24(epor)-22(t. )]TJ /T1_4 1 Tf [(Int J Surg Case R)21(ep)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2018;50:1\2264. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ijscr.2018.06.009)Tj 0 0 0 1 k /GS1 gs -0.002 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(int)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(J, Castel)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC [(J, M\343o de F)10(er)-24(r)-32(o)]TJ /Span<>> BDC ( )Tj EMC [(S. Jejunal L)-32(ipoma, an)]TJ /Span<>> BDC ( )Tj EMC [(U)13(ncommon )]TJ 0.012 Tc 0.455 Tw -1.796 -1.25 Td (Cause of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-32.3(ointest)-32.4(inal Bleeding. )]TJ /T1_4 1 Tf [(GE P)14.7(or)-40.4(t J Gastroenterol)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2018;25\(6\):337\226339. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1159/000486560)Tj 0 0 0 1 k /GS1 gs 0.311 Tw T* (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ingason)Tj /Span<>> BDC ( )Tj EMC [(A)44(B, T)47.1(heod)-16(or)-10(s)]TJ /Span<>> BDC ( )Tj EMC [(A, A)-25(gustsson)]TJ /Span<>> BDC ( )Tj EMC [(A)35(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Giant gastr)-37(ic )]TJ 0.003 Tc 0.35 Tw -1.796 -1.25 Td [(l)-31(ipoma )0.6(successfull)35(y )0.5(r)-24(emoved )0.5(b)12(y )0.6(end)-16(oscopic )0.5(submucosal )0.6(dissec)]TJ 0 Tc 0 Tw (-)Tj 0.007 Tc 0.349 Tw T* [(t)-31.7(ion: case r)-23.6(epor)-21.6(t and sy)-12.6(stema)15.3(t)-31.6(ic r)-23.6(ev)-15.6(iew. )]TJ /T1_4 1 Tf [(Scandinavian Jour)-13.7(nal)7( )]TJ 0 Tc 0.111 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (Gastroenterology)Tj /T1_1 1 Tf [(. 2018;53\(8\):1018\2261024. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/0036552)Tj T* (1.2018.1495259)Tj 0 0 0 1 k /GS1 gs 0.047 Tw T* (20.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Menegon )0.5(T)40(assell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(F, )0.5(U)15(r)-23.9(r)-33(ar)-32(o)]TJ /Span<>> BDC ( )Tj EMC 10.901 0 Td [(F, )0.5(S)-24(c)-24(iaud)-15.9(one)]TJ /Span<>> BDC ( )Tj EMC [(G, )0.5(e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Col)30.1(onic L)-31.9(ipoma )]TJ 0.023 Tw -12.697 -1.25 Td [(Causing )0.6(Bo)-14(wel )0.6(Intussuscept)-32(ion: )0.6(An)]TJ /Span<>> BDC ( )Tj EMC 14.478 0 Td [(U)13(p-t)17(o-Da)15(te )0.6(Sy)-13(stema)15(t)-32(ic )0.6(R)13(ev)-16(iew. )]TJ /T1_4 1 Tf 0 Tw 12.722 0 Td (J )Tj 0.023 Tw -27.2 -1.25 Td (Clin Med)Tj /T1_1 1 Tf [(. 2021;10\(21\):5149. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3390/jcm10215149)Tj 0 0 0 1 k /GS1 gs 0.139 Tw T* (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)35(u)]TJ /Span<>> BDC ( )Tj EMC (HG, Ding)Tj /Span<>> BDC ( )Tj EMC [(YM, T)40(an)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(safe and ef)-56(f)-28(ic)-24(ient str)-32.9(a)15(teg)16(y for )]TJ 0.05 Tw -1.796 -1.25 Td [(end)-16(oscopic r)-24(esec)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ar)-32(ge, gastr)-32(ointest)-31.9(inal l)-31(ipoma. )]TJ /T1_4 1 Tf (Surg Endosc)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2007;21\(2\):265\226269. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00464-006-0059-7)Tj 0 0 0 1 k /GS1 gs 0.251 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(iech)]TJ /Span<>> BDC ( )Tj EMC [(T, W)12(al)16(ch)]TJ /Span<>> BDC ( )Tj EMC [(A, W)22(er)-15(ner)]TJ /Span<>> BDC ( )Tj EMC [(M. Hist)17.1(op)32(a)15(t)-13(hol)30(o)-16(gical Cl)-16(assif)-28(ica)15(t)-32(ion )]TJ 0.012 Tc 0.424 Tw -1.796 -1.25 Td [(o)0.5(f)]TJ /Span<>> BDC 0.838 0 Td ( )Tj EMC [(N)-13.5(o)0.6(n)0.5(n)0.5(e)0.6(o)0.5(p)0.5(l)-15.4(a)0.5(s)0.5(t)-31.4(i)0.5(c)0.5( a)0.6(n)0.5(d)0.5( N)0.5(e)0.6(o)0.5(p)0.5(l)-15.4(a)0.5(s)0.6(t)-31.5(i)0.5(c)0.6( G)0.5(a)0.5(s)0.6(t)0.5(r)-31.5(o)0.6(i)0.5(n)0.5(t)0.6(e)0.5(s)0.6(t)-31.5(i)0.5(n)0.6(a)0.5(l)0.5( S)0.5(u)0.6(b)0.5(m)0.6(u)0.5(c)0.5(o)0.5(s)0.6(a)0.5(l)12( )]TJ 0.009 Tc -0.009 Tw -0.838 -1.25 Td [(L)34.6(esions. )]TJ /T1_4 1 Tf 3.917 0 Td [(Endoscop)11.6(y)]TJ /T1_1 1 Tf 0.352 Tw [(. 2005;37\(7\):630\226634. d)-16.3(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw (10.1055/s-2005-)Tj 0 Tc 0 Tw -3.917 -1.25 Td (870127)Tj 0 0 0 1 k /GS1 gs 0.218 Tw T* (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\264\036\030\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\214., \207\t\f\021\030\024\r\f\022\026\016)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \212\024\035\020\026\001\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\206.\204., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.073 Tw -1.796 -1.25 Td (\233\027\007\024\f\024\027\024\020\030\026\235\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \027\036\220\023\017\021\036\035\ \017\026\035\034\027\t\b \024\023\031\b\024\035\036\005 \023\017\013\036\ )Tj 0 Tw (-)Tj 0.108 Tw T* (\r\024\007\026, \032\036\035\031\007\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\017. )Tj /T1_4 1 Tf 0 Tw (\230\n\024\033\027\032\022\026\027\025\023\020\f\017\025\020\t )Tj 0.025 Tc 0.891 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 1.672 0 Td [(\n\f\022\025\022\007\027\024\n\020\t )0.5(\b\020\024\023\032\031\204\025\023\027\032\031\f\031\b\022\t)]TJ /T1_1 1 Tf [(. )0.5(2010;\(10\):29\22631. /)25.1( )]TJ 0.012 Tc 0.441 Tw -1.672 -1.25 Td [(S)-15.9(hcher)-24(bakov)]TJ /Span<>> BDC ( )Tj EMC [(P.L., By)-12.9(str)-32(ovsk)-17(a)15.1(y)22.1(a)]TJ /Span<>> BDC ( )Tj EMC [(E.V., Dol)16.1(gashev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(G.M., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al.)12( )]TJ 0 Tc 0.321 Tw T* [(End)-16(osono)-15.9(gr)-33(aphy in dia)-17(gnost)-32(ics )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(non-epi)-24(t)-13(hel)-30.9(ial tumor)-10(s )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.001 Tw T* [(esopha)-17(gus, st)17(oma)-17(ch and duodenum. E)]TJ /T1_4 1 Tf [(xper)-37(imental and clinical g)12(astro)]TJ 0 Tw (-)Tj T* (enterology. )Tj /T1_1 1 Tf 0.023 Tw 4.707 0 Td (2010;\(10\):29\22631. \(In Russ.\).)Tj 0.146 Tw -4.707 -1.25 Td (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Hw)-12(ang)]TJ /Span<>> BDC ( )Tj EMC [(JH, Saunder)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(MD, Rul)35.1(y)22(ak)]TJ /Span<>> BDC ( )Tj EMC [(SJ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(p)25(r)-32(ospec)-16(t)-32(i)-16(ve stud)17.1(y )]TJ 0.319 Tw -1.796 -1.25 Td [(com)10(p)32(ar)-37(ing end)-16(oscopy and EUS in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(ev)-15(al)35(ua)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (GI subepi)Tj 0 Tw (-)Tj 0.004 Tc 0.35 Tw T* [(t)-13.1(hel)-31.1(ial )0.5(masses. )]TJ /T1_4 1 Tf [(Gastrointestinal Endoscop)11.9(y)]TJ /T1_1 1 Tf [(. 2005;62\(2\):202\226208.)4( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1016/S0016-5107\(05\)01567-1)Tj 0 0 0 1 k /GS1 gs -0.078 Tw -1.847 -1.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(a)15(yl)30(or)]TJ /Span<>> BDC ( )Tj EMC [(AJ, S)15(tew)-12(ar)-22(t)]TJ /Span<>> BDC ( )Tj EMC (ET, Dodds)Tj /Span<>> BDC ( )Tj EMC [(W)31(J. Gastr)-32(ointest)-32(inal l)-30.9(ipomas: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-32.9(adio)]TJ 0 Tw (-)Tj 0.26 Tw -1.796 -1.25 Td [(l)30(o)-16(gic and p)32(a)15(t)-13(hol)30(o)-16(gic r)-24(ev)-16(iew. )]TJ /T1_4 1 Tf [(Amer)-36.9(ican Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(R)19(oentg)12(enology)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1990;155\(6\):1205\2261210. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.2214/ajr.155.6.2122666)Tj 0 0 0 1 k /GS1 gs 0.013 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\203\036\004\017\023\026\005)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \210\030\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\224., \205\036\007\024\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\212. \233\211\222\002\031\022\026. \217\031\022\024\r\024\007\f\021\ \r\024 )Tj 0.241 Tw -1.796 -1.25 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \031\035\034\021\ \030\026\f\024\027\024\020\030\026\235\017\017. \204: \215\030\026\022\021\ \017\004\036\f\022\026\016 \n\036\007\017)Tj 0 Tw (-)Tj 0.216 Tw T* [(\006\017\027\026; 2013. / Nechip)32(a)15.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A.M., Or)-30(l)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.Y)35(u., F)10(ed)-16(or)-32(ov)]TJ /Span<>> BDC ( )Tj EMC [(E.D. EUSbo)-16(ok. )]TJ 0.086 Tw T* [(Guide t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(end)-16(oscopic ul)56(tr)-32.9(asono)-16(gr)-33(aphy. M: P)35(r)-33(a)-17(c)-16(t)-31.9(ical medic)-23.9(ine; 2013. )]TJ 0.023 Tw T* (\(In Russ.\))Tj 0.166 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ja)-17(cobson)]TJ /Span<>> BDC ( )Tj EMC [(BC, Bha)15(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(A, G)20(r)-24(eer)]TJ /Span<>> BDC ( )Tj EMC [(KB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)16(CG Cl)-31(inical Guidel)-30.9(ine: )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_5 1 Tf 25 0 0 25 505.5644 56.0378 Tm (179)Tj ET endstream endobj 87 0 obj <>>>/Subtype/Form>>stream 1 0.68 0 0.12 k /GS0 gs 42.52 54.638 453.543 1.375 re f 42.52 52.257 453.543 1.375 re f 42.52 755.476 453.543 1.375 re f endstream endobj 84 0 obj <> endobj 107 0 obj <> endobj 241 0 obj <> endobj 242 0 obj <> endobj 243 0 obj <>stream H\ˎ0D|E݋}Kb1 3@AB?[V"oέrv{5:\|N8}85|_p8ye۝٬~oãzj<~y8woӏW^|^i,i_r5i/x|sse!z̷~þ{˓Y=~l3~o^OaoѵHڪv Q/z9Aj9Fn8B^P_Qsu[Co9&B߀ǐߠ!s j[<ːߠ!iohxboѯ!չ[uO~~:Zj@mF6Q6Ԩo.+j`nѻ#3tqq:u:2;0;2;0;2Zrdv`v-5|2 f ބ !AȠkX `2 !(=x(PCB =xX?~`X?~`Oೂ>O?O?O?D?~!JrdE4XDcE4XDcRkbL ]"R D4(PR D(ЩaI%d*SR (i.~k 4׍Ԕ@G!n"jJ f5 8 ?^vSQ~А_7XS&iJ÷X-] E5uc/x}kZ(8dz8a0z멊38  Z*ɮ endstream endobj 244 0 obj <>stream HdTkTSW>< \ 7xBVKEBa@Bj>Z[AMJP*"YhE ,,ƷEWq:c&x33?][{sPhELOT%Eϋ**Z7ugY -lgk^x%X+\6>!|c/f?s_iz}F$uZo~~~n:+j1٣/ޕ-k#,DYCcT?{)Oky7!,YVU*{kߺAkg+5r080#&vM}Tz9yyDi23ѻh`.fg8)t.2.\>l8,2nb Q|JF1l[kS4_tf>\+?BYH]Z^LhT'P}) Nx㘷ZMQum}d_ _ͬ~JRʐZOe>Q$teRG;aQg7nj&~GsH>Rì6KD,Fr8<q"AAo`y&)R3TK(D*3VقOIVRՠinnhhn4TW:,߾ KmL29UE6{D & ͽ~ڼ<)]PX.LքQA ɴgWhu`*_rRԾ62]L/[]/_'ʽZ9:D Վ_ҟ굖_ 2 fk͉ 6d9m&ԙӄO:"4w=-8s<UB'3w׉k#~h<]AxǸTb]Ǣ 5M)@:7],$ w0ԶY8v|颏򊴛DM뫋wMUNh.WR)RRqBݥ5~w-!>En)~~zώI߾G|eiӘ`]J 7#i>rQ7w;N5&h Emܷ_N܊` E"ݡ6}(^S_N=(D^E/0rǶJ9Aܩ&Cft5Z#I&ΊόyHϞ!r {=e۶h`z ^8~IRIr\Gk&x˱,Fr^W[oFgs*J3?xIhD#쌝%AMv- %e A>[hyRŁz_޻&*1##IlGGGGi ZAۧW] ҭ=o^*K 0 @Qok+%'&|m&},N]1׵CWvFȵ VEͲh,dƼᬘ@}oպch^ ۓ3\싲jj²ջzPU O局@ ⣃R((y#7^Hn+]Jι?Qk;;7;{};_Wtcx;|(o-WǕ=`bQr0sTg#)"'b:--3 3#lptΩ}hqN'Р- ] 'B8: TR@8㑟df)={m:RE2hyEnܕ˭{=.iБT:.LC7 }'3D8q`A#Pм+R#R^H$HxCrXqgQ#{bbADK@:EE+_Tr iD"o!1SiۢS KXuL;?t̍#[afF> [,F@:wYV,K HBC2Rłԑ͙['X',j*вH Rh$eXXslXti _E >6sx`NA$ B>89,"=褎1]k@|b\wXhP; M@vϪ;xlQ:<]xDٸB?)U% F{@M+vkKo?OiL铑!!䓯Rn o@`yuen5 PɢM N%Q;Z/-AiG'Ɖ6 :nAUx|365/MuaP r @[*·eWM4W&+>< O毉LeB_;@X3<[E o_Ө(BoZJGIӿ8.Lɐ酫9ȟ!E4{Z6z{R8~! j:OgRDKۡ&Ɣ]*\5GKM X0n?[~%Ymr N&\qu\h;^ 2q)98ӧ1_odzv/fL O+Pgg30N盳:m4z{R4y?sڶL]mMc^n'uroO ‡P:x$uc%jQMeN ??h!+S3cR(8)MZ`O<3x;+zsg2b tĶ=iL&j2E;[GiiRU颤mΔV+hn'B 8Zn엏_^j753C%^=n1c5: zƠI 9 LR)Ӥ)cuJ&@l{Hk=Ku/M|2*j;YHkr3=BTnO}mfQ"^'7+d?xYq LD79_ _zѨJ\TE8ls*|j6 c,P ߨdv.Ԁ?̛ P*"!ΛǥM^&ódhw9x/Uuޒh6K}{j(jۤT"l"2E@GAdU@@`! 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\221\r)-23.3(\032)-18.9(\030)-13.7(\005)-13.7(\n)-9.2(\031)-9.4(\021)]TJ /Span<>> BDC 19.037 0 Td ( )Tj EMC [(\215.)24.7(\205)-21(.)]TJ /T1_0 1 Tf 0 Tc 0.594 Tw -19.037 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.6(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_2 1 Tf [( \003)19.4(\235)4.7(\032)3(\020)1.8(\033)4.5(\027\023)12.2(\t)10.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.04 Tw T* [(\211)11.7(\020)-5.2(\f)9.6(\022\r)23.8(\f)9.7(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.8(.)29.3(\206)93.9(.)7.8(, \216)109.3(\021)-0.8(\031)14.2(\016)2.2(\030)1.9(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, \206)28.6(\t)1.7(\240)8.1(\006)2.8(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)29.3(\002)28.8(.)7.8(, \202)15.6(\031)4.9(\032\031)10.1(\f)3.3(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\216)122(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.015 Tw T* [(\004)15.1(\020)4.8(\n)-21.2(\f)9.6(\022)7.2(\025)9.6(\020)]TJ /Span<>> BDC ( )Tj EMC 3.658 0 Td [(\217)27.6(.)28.5(\211)24.3(.)7.8(, )0.6(\216)98(\r)6.6(\024)9.8(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC 4.766 0 Td [(\036)22.8(.)28.5(\211)24.3(.)7.8(, )0.6(\002)20.8(\021)2.1(\020)4.3(\025)3.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 5.135 0 Td [(\002)28.8(.)29.3(\002)28.8(.)7.8(, )0.6(\035)11.7(\031)2.8(\200)-1.9(\026)6.9(\020)1.8(\023)4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 6.526 0 Td [(\215)19.4(.)20.1(\215)19.4(.)7.8(, )]TJ 0 Tw -20.085 -1.218 Td [(\001)14.6(\022)7.7(\n)9.8(\031)10.1(\f)9(\020)4.4(\235)19.4(\007\r)8.8(\n)]TJ /Span<>> BDC ( )Tj EMC [()65(.)28.5(\211)24.3(.)7.8(, \205)8.8(\022)6.7(\030)1.9(\031)4.9(\032)6.4(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)28.5(\211)24.3(.)7.8(, \205)4.6(\023)6.9(\020)1.8(\032)13.2(\007)3.8(\027)2.3(\025)10.7(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.5(.)-9.6(\220)1.4(.)]TJ /T1_0 1 Tf 0.002 Tc 0.282 Tw 0 -1.218 TD [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf 0 Tc 0.284 Tw 7.978 0 Td [( \003)19.5(\235)4.7(\032)3(\020)1.8(\033)4.5(\027\023)12.2(\t)10.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)7.3(\003)-2.3(.)7.8(, \211)11.7(\020)-5.1(\f)9.6(\022\r)23.8(\f)9.6(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.8(.)29.3(\206)93.9(.)7.8(, )]TJ 1.162 Tw -7.978 -1.218 Td [(\216)109.3(\021)-0.8(\031)14.2(\016)2.2(\030)1.9(\027)6.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, )0.5(\206)28.6(\t)1.7(\240)8.1(\006)2.7(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC 12.454 0 Td [(\211)24.3(.)29.3(\002)28.8(.)7.8(, )0.5(\202)15.6(\031)4.9(\032\031)10.1(\f)3.3(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC 8.001 0 Td [(\216)122(.)7.3(\003)-2.3(.)7.8(, )]TJ 0 Tw -20.455 -1.218 Td [(\004)8.8(\027)-0.9(\032)5.9(\203)5.5(\022)-2.3(\f)11.6(\017)0.7(\027)6.5(\021)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.9(.)27.5(\221)18.5(.)7.8(, \004)15.2(\022)4.7(\032\031)5.9(\b)3.7(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)43.7(\205)-2.1(.)]TJ /T1_0 1 Tf 0 -1.218 TD [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.679 Tw [( \221)19.2(\r)-4.2(\032\030)5.3(\005)5.3(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.4(.)43.8(\205)-2.1(.)7.8(, \003)6.4(\b)3.7(\027)2.7(\235)7.7(\n)12.7(\022)7.3(\025)9.5(\020)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)28.5(\211)24.3(.)7.9(, )]TJ 0 Tw T* [(\202)15.6(\031)4.9(\032)7.8(\255)18.5(\027)6.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.9(.)27.5(\224)26.6(.)7.8(, \004)15.1(\022)4.8(\032\031)5.9(\b)3.7(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)43.7(\205)-2.1(.)]TJ /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf -0.005 Tc 0.005 Tw [( M)5.5(i)2.9(kha)-7(i)2.4(l)]TJ /Span<>> BDC 16.384 0 Td ( )Tj EMC [(S)-2.9(.)]TJ /Span<>> BDC 0.99 0 Td ( )Tj EMC [(B)2(u)1.1(r)-3.6(d)-8(y)-1.2(uk)7.9(o)-5.6(v)]TJ /T1_0 1 Tf 0 Tc 1.563 Tw -17.374 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.8(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-44.6(s)2.3(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -0.043 Tw T* [(N)8.7(a)-2(i)9.4(r)7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(H)9.7(a)-5.9(y)-2(r)7.7(a)-0.8(p)-7.2(e)-4.4(t)-30(y)3.8(a)-0.7(n)-6(, I)3.2(ld)1.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)26(al)4.3(i)9.3(u)2.8(l)4.3(i)8.4(n)-6(, A)3.6(l)4.9(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)5.8(v)7.6(o)12.3(z)8.8(d)-0.9(e)-4(v)33.6(, )]TJ -0.061 Tw T* [(V)25.9(al)4.8(e)-1.7(r)-35.3(i)3.5(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)3.8(a)3.5(b)0.9(t)-29(s)4.9(e)-4(v)10.8(a)-14(, G)4.7(r)-35.3(i)5.8(g)-2.5(o)1.3(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)1.4(r)2.4(o)-1.1(l)4.8(e)-4(v)33.6(, O)-6(x)5(a)-0.8(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(P)30.8(a)1.7(k)11.6(l)4.3(i)8.4(n)4.8(a)-14(, )]TJ 0.07 Tw T* [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(us)4.9(e)-4(v)10.8(a)-14(, I)3.2(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(I)14(v)10.8(a)-0.8(n)1.9(o)-0.6(v)33.6(, M)5.2(a)1.7(k)-17.5(s)-8.3(i)8.5(m)]TJ /Span<>> BDC ( )Tj EMC [(M)5.4(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-5.5(o)2.8(k)5.3(h)5.2(m)4.3(a)-4.9(t)1.4(o)-0.6(v)33.6(, )]TJ 1.264 Tw T* [(T)49.7(a)-4.9(t)-25.2(i)5.9(a)-0.7(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8(i)7.9(k)13(o)-1.1(l)3.3(a)-2(i)2.6(c)1.8(h)8.2(u)4.6(k)-17.4(, V)25.9(a)-3(s)-8.3(i)7.4(l)4.4(iy)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)21.5(i)3(d)-0.9(o)1.3(r)-35.3(i)8.4(n)-6(, )]TJ -0.002 Tc 0.002 Tw T* [(D)-8.1(e)-4.6(n)4.2(i)9(s)]TJ /Span<>> BDC 2.107 0 Td ( )Tj EMC [(D)21.9(.)]TJ /Span<>> BDC 1.047 0 Td ( )Tj EMC [(S)14.3(ta)-1.8(r)0.9(che)-4.6(n)5.5(k)10.9(o)-2.6(v)]TJ /T1_0 1 Tf 0 Tc 0.899 Tw -3.155 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-35.9(t)-20.1(:)]TJ /T1_2 1 Tf [( N)8.8(a)-2(i)9.4(r)7.7(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(H)9.7(a)-5.9(y)-2(r)7.7(a)-0.8(p)-7.2(e)-4.4(t)-29.9(y)3.8(a)-0.8(n)-6(, )]TJ -0.002 Tw T* [(I)3.2(ld)1.9(ar)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(V)25.9(al)4.3(i)9.3(u)2.8(l)4.3(i)8.4(n)-6(, A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)5.8(v)7.6(o)12.3(z)8.8(d)-1(e)-3.9(v)33.5(, V)25.9(al)4.8(e)-1.7(r)-35.3(i)3.4(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-9(y)3.8(a)3.5(b)0.9(t)-29.1(s)4.9(e)-3.9(v)10.8(a)-14(, )]TJ 0 Tw T* [(G)4.7(r)-35.3(i)5.8(g)-2.5(o)1.3(r)-40.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)1.3(r)2.4(o)-1.1(l)4.9(e)-4(v)33.6(, I)3.2(l)11(y)3.8(a)]TJ /Span<>> BDC ( )Tj EMC [(B)10.2(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24.1(e)-1.7(r)-27.8(\243)8(l)4.8(e)-4(v)33.6(,)-20.4(S)5.6(e)-1.7(r)2.3(g)-2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)-7.4(i)9.4(r)2.4(o)-4.4(g)-2.5(ov)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.382 Tw 3.238 0 Td [( M)10.5(i)7.9(k)5.3(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)7(u)6.1(r)1.5(d)-3(y)3.8(u)4.6(k)12.9(o)-0.6(v)33.6(, N)8.7(a)-4.9(t)2.3(al)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)2.8(g)-2.5(e)-2.5(y)5.7(k)-18.5(i)8.4(n)4.8(a)-14(, )]TJ 0 Tw -3.238 -1.218 Td [(I)7.5(r)-35.3(i)8.4(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.8(u)7.7(. K)13.3(o)1.3(r)-14.6(z)8.1(h)1.9(e)-4(v)10.8(a)-13.9(, S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)-7.3(i)9.4(r)2.4(o)-4.4(g)-2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\034\025\203\017\022\215\032\037\034\223 \017\224 \032\026\020\017\022\032\ \225 \(ORCID\))Tj /T1_0 1 Tf 0.255 Tw 0 -1.218 TD (\207\031\030\007\033\022\024\r \204\017\b\026\017\035 \222\036\030\020\036\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tw (-)Tj 0.174 Tw T* [(\235\036\007\030\t )0.5(\220\027\007\024\f\022\024\023\017\017 )0.6(\205\206\207\210\211 )0.5(\212\215\210 )0.5(\217\204\202\203\215\210 )0.6(\204\017\027\007\030\026\r\026 )]TJ 0.107 Tw T* (\217\024\f\f\017\017, \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\ \021 \206\207\211\003 \253\204\024\f\022\024\r\f\022\017\005 \n\027\024\020\ \024)Tj 0 Tw (-)Tj 0.518 Tw T* [(\023\030\024\235\017\035\034\027\t\005 )0.6(\022\035\017\027\017\022\024-\007\017\026\020\027\024\f\021\017\004\036\f\ \022\017\005 )0.6(\006\036\027\021\030 )0.6(\017\n. )]TJ 0.352 Tw T* (\222.\215.)Tj /Span<>> BDC ( )Tj EMC (\207\024\021\022\017\027\026 \212\003\204\273, \030\031\022\024\r\024\007\ \017\021\036\035\034 \006\036\027\021\030\026 \220\027\007\024\b\017)Tj 0 Tw (-)Tj 0.07 Tw T* (\030\031\030\020\017\017 \205\036\007\036\030\026\035\034\027\026\016 \f\ \036\021\034 \022\035\017\027\017\022 \253\213\r\030\024\024\027\022\024\ \273; ORCID )Tj 0 Tw T* (0000-0003-4690-9335)Tj -0.039 Tw T* (\202\005\030\026\023\036\021\016\027 \203\026\017\030\026 \202\027\007\030\ \026\027\017\022\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.232 Tw T* [(\206\207\211\003 )0.5(\253\204\024\f\022\024\r\f\022\017\005 )0.6(\n\027\024\020\024\023\030\024\235\017\035\034\027\t\005 )0.6(\022\035\017\027\017\022\024-\007\017\026)]TJ 0 Tw (-)Tj 0.222 Tw T* (\020\027\024\f\021\017\004\036\f\022\017\005 \006\036\027\021\030 \017\n\ . \222.\215.)Tj /Span<>> BDC ( )Tj EMC (\207\024\021\022\017\027\026 \212\003\204\273; ORCID )Tj 0 Tw T* (0000-0002-7295-8037)Tj 0.434 Tw T* [(\200\026\035\017\031\035\017\027 \230\035\034\007\026\030 )0.5(\217\026\031\235\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0005-6110-8941)Tj -0.077 Tw T* (\206\r\024\007\036\r \202\035\036\022\f\036\005 \202\035\036\022\f\026\027\ \007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\r\036\007\031\033\013\017\005 \024\021\007\036)Tj 0 Tw (-)Tj -0.031 Tw T* (\035\036\027\017\036\n \220\027\007\024\f\022\024\023\017\017 \206\207\211\ \003 \253\206\025\207 \017\n. \230.\200.)Tj /Span<>> BDC ( )Tj EMC (\212\026\r\t\007\024\r\f\022\024\020\024 )Tj 0 Tw T* (\212\003\204\273; ORCID 0000-0002-3096-2070)Tj 0.588 Tw T* (\025\024\030\024\035\036\r \206\030\017\020\024\030\017\005 \202\035\036\ \022\f\036\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 0.109 Tw T* [(\220\027\007\024\f\022\024\023\017\f\021 \205\206\202\211 \253\203\026\006\ \017\024\027\026\035\034\027\t\005 )0.5(\n\036\007\017\006\017\027\f\022\017\005 \017\f)]TJ 0 Tw (-)Tj 0.167 Tw T* [(\f\035\036\007\024\r\026\021\036\035\034\f\022\017\005 )0.5(\006\036\027\021\030 \007\024\030\024\r\034\016 \007\036\021\036\005\273\ \204\017\027\007\030\026\r\026 )]TJ 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0001-5730-3684)Tj 0.269 Tw 23.244 64.543 Td [(\215\026\022\035\017\027\026 )0.5(\210\022\f\026\027\026 )0.6(\200\035\026\007\017\n\017\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.923 0 Td [(\227 )0.5(\007.\n.\027., )0.5(\027\026\031\004\027\t\005 )]TJ 0.257 Tw -13.923 -1.218 Td [(\022\024\027\f\031\035\034\021\026\027\021 )0.6(\035\026\002\024\030\026\021\024\030\017\017 )0.5(\017\027\027\024\r\026\006\017\024\027\027\024\005 )0.5(\023\026\021\024\n\024\030)]TJ 0 Tw (-)Tj 0.337 Tw T* (\235\024\035\024\020\017\017 \206\207\211\003 \253\204\024\f\022\024\r\f\ \022\017\005 \022\035\017\027\017\004\036\f\022\017\005 \027\026\031\004\ \027\t\005 )Tj 0.08 Tw T* (\006\036\027\021\030 \017\n. \202.\222.)Tj /Span<>> BDC ( )Tj EMC (\214\024\020\017\027\024\r\026\273 \212\003\204, \020\035\026\r\027\t\005\ \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj -0.084 Tw T* (\021\030\031\007\027\017\022 \035\026\002\024\030\026\021\024\030\017\017\ \220\035\036\022\021\030\024\027\027\024\005 \n\017\022\030\024\f\022\024\ \023\017\017 \205\206\207\211 )Tj 0.773 Tw T* (\253\203\026\006\017\024\027\026\035\034\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \017\f\f\035\036\007\024\r\026\021\036\035\034\f\022\017\ \005 )Tj 0.246 Tw 0 -1.218 TD (\006\036\027\021\030 \b\017\030\031\030\020\017\017 \017\n. \202.\200.)Tj /Span<>> BDC ( )Tj EMC (\200\017\001\027\036\r\f\022\024\020\024\273 \204\017\027\007\030\026\r\ \026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017; ORCID 0000-0001-6373-1888)Tj 0.07 Tw T* (\217\016\002\006\036\r\026 \200\026\035\036\030\017\016 \230\020\024\030\ \036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026\031\004\027\t\005 \f\024)Tj 0 Tw (-)Tj 0.271 Tw T* (\021\030\031\007\027\017\022, \026\f\023\017\030\026\027\021 \024\021\007\ \036\035\026 \220\027\007\024\f\022\024\023\017\017, \204\024\f\022\024\r\ \f\022\017\005 )Tj 0.078 Tw T* (\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034\f\ \022\017\005 \024\027\022\024\035\024\020\017\004\036\f\022\017\005 \017\ \027\f\021\017\021\031\021 )Tj 0.138 Tw T* (\017\n. \215.\202.)Tj /Span<>> BDC ( )Tj EMC (\206\036\030\006\036\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \235\017\035\017\026\035 \205\206\207\211 \253\203\204\230\037 \030\ \026\007\017\024\035\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; O\ RCID 0000-0003-3174-7695)Tj 0.066 Tw 0 -1.218 TD (\202\020\036\005\022\017\027\026 \203\026\021\026\035\034\016 \200\035\026\ \007\017\n\017\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031\033)Tj 0 Tw (-)Tj -0.03 Tw 0 -1.218 TD (\013\026\016 \024\021\007\036\035\036\027\017\036\n \220\027\007\024\f\022\ \024\023\017\017 \025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 )Tj -0.02 Tw T* (\215\030\036\f\027\036\273, \202\210 \253\204\213\212\222\230-2\273; ORC\ ID 0000-0001-8726-0929)Tj 0.17 Tw T* (\206\031\f\036\r\026 \213\r\020\036\027\017\016 \200\035\026\007\017\n\017\ \030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0009-3782-8366)Tj 0.35 Tw T* (\230\r\026\027\024\r \230\035\034\016 \230\020\024\030\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 \025\212\037\ )Tj 0.121 Tw T* (\253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; ORCID )Tj 0 Tw T* (0009-0002-8492-2856)Tj 0.033 Tw T* (\025\024\030\032\036\r\026 \230\030\017\027\026 \224\030\034\036\r\027\026\ )Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \030\031\022\024\r\024\007\017\021\036\035\034 \220\027\ )Tj 0 Tw (-)Tj 0.194 Tw T* [(\007\024\f\022\024\023\017\004\036\f\022\020\024 \006\036\027\021\030\026\ , \f\021\026\030\001\017\005 )0.5(\027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 )]TJ 0.232 Tw T* [(\206\207\211\003 )0.5(\253\204\024\f\022\024\r\f\022\017\005 )0.6(\n\027\024\020\024\023\030\024\235\017\035\034\027\t\005 )0.6(\022\035\017\027\017\022\024-\007\017\026)]TJ 0 Tw (-)Tj 0.11 Tw T* (\020\027\024\f\021\017\004\036\f\022\017\005 \006\036\027\021\030 \017\n\ . \222.\215.)Tj /Span<>> BDC ( )Tj EMC (\207\024\021\022\017\027\026 \212\003\204\273, \026\r. \022\026)Tj 0 Tw (-)Tj 0.093 Tw T* (\235\036\007\030\024\005 \220\027\007\024\f\022\024\023\017\017 \205\206\ \207\210\211 \212\215\210 \217\204\202\203\215\210 \204\017\027\007\030\ \026\r\026 )Tj 0 Tw T* (\217\024\f\f\017\017; ORCID 0000-0002-5984-5660)Tj 0.358 Tw T* (\214\024\b\n\026\021\024\r \204\026\022\f\017\n \204\017\b\026)Tj /Span<>> BDC (\005)Tj EMC (\035\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \020\035\026\r\027\t\005 )Tj 0.225 Tw T* [(\027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022, )0.5(\026\r\036\007\031\033\013\017\005 \024\021\007\036\035\036\027\017\036\ \n \220\027\007\024)]TJ 0 Tw (-)Tj 0.551 Tw T* (\f\022\024\023\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\ \017)Tj /Span<>> BDC (\005)Tj EMC ( \205\206\202\211 \253\203\026\006\017\024\027\026\035\034\027\t\005 )Tj 0.583 Tw T* (\n\036\007\017\006\017\027\f\022\017\005 \017\f\f\035\036\007\024\r\026\021\ \036\035\034\f\022\017\005 \006\036\027\021\030 \007\024\030\024\r\034\016\ )Tj 0.641 Tw T* (\007\036\021\036\005\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\ \017, \023\030\024\235\036\f\f\024\030 \022\026\235\036\007\030\t )Tj 0.792 Tw T* (\007\036\021\f\022\024\005 \b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\035\024\020\017\017-\026\027\007\030\024\035\024\020\017\017\ \017\n. )Tj 0.251 Tw T* (\214.\215.)Tj /Span<>> BDC ( )Tj EMC (\202\035\036\022\f\026\027\007\030\024\r\026, \205\206\202\210\211 \200\210\ \215\036\030\r\t\005 \204\024\f\022\024\r\f\022\017\005 )Tj 0.586 Tw T* [(\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 )0.6(\n\036\007\017\006\017\027\f\022\017\005 )0.6(\031\027\017\r\036\030\f\017\021\036\021 )0.5(\017\n\036)]TJ 0 Tw (-)Tj 0.361 Tw T* (\027\017 \230.\204.)Tj /Span<>> BDC ( )Tj EMC (\222\036\004\036\027\024\r\026 \204\017\027\017\f\021\036\030\f\021\r\026\ \007\030\026\r\024\024\b\030\026\027\036\027\017\016 )Tj 0.171 Tw T* (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017 \ \(\222\036\004\036\027\024\r\f\022\017\005 \211\027\017\r\036\030\f\017\021\ \036\021\); )Tj 0 Tw T* (ORCID 0000-0002-8305-7592)Tj -0.058 Tw T* [(\203\017\022\024\035\026\005\004\031\022 \221\026\021\034\016\027\026 )0.5(\200\017\022\021\024\030\024\r\027\026)]TJ /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0008-4899-7221)Tj 0.794 Tw T* (\215\036\030\235\017\035\034\036\r \230\035\034\016 \207\024\030\017\f\024\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \r\030\026\004-)Tj 0.444 Tw T* (\220\027\007\024\f\022\024\023\017\f\021, \205\017\035\017\026\035 \253\210\ \027\022\024\035\024\020\017\004\036\f\022\017\005 \006\036\027\021\030 \ \2231 )Tj 0.058 Tw T* (\206\024\030\024\007\f\022\024\005 \022\035\017\027\017\004\036\f\022\024\ \005 \002\024\035\034\027\017\006\t \017\n\036\027\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\224\007\017\027\026 )Tj 0 Tw T* (\212\003\204\273; ORCID 0000-0002-2685-8721)Tj -0.063 Tw T* (\215\017\030\024\020\024\r \222\036\030\036\005 \222\036\030\020\036\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \026\r\036\007\031\033\013\017\005 \024\021\007\036\ )Tj 0 Tw (-)Tj 0.064 Tw T* [(\035\024\n )0.5(\220\027\007\024\f\022\024\023\017\017, )0.5(\204\024\f\022\024\r\f\022\017\005 )0.5(\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034)]TJ 0 Tw (-)Tj 0.17 Tw T* (\f\022\017\005 \024\027\022\024\035\024\020\017\004\036\f\022\017\005 \017\ \027\f\021\017\021\031\021 \017\n. \215.\202.)Tj /Span<>> BDC ( )Tj EMC (\206\036\030\006\036\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.074 Tw T* (\235\017\035\017\026\035 \205\206\207\211 \253\203\204\230\037 \030\026\007\ \017\024\035\024\020\017\017\273 \204\017\027\007\030\026\r\026 \217\024\ \f\f\017\017; )Tj 0 Tw T* (ORCID 0000-0002-8101-2155)Tj -0.076 Tw T* (\222\017\007\024\030\017\027 \200\026\f\017\035\017\005 \200\035\026\007\ \017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-\220\027\007\024\f\022\024\023\017\f\021 )Tj 0.241 Tw T* (\025\212\037 \253\204\213\212\222\230 \027\026)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\005 \215\030\036\f\027\036\273, \202\210 \253\204\ \213\212\222\230-2\273; )Tj 0 Tw T* (ORCID 0009-0003-1836-7492)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8526 56.0378 Tm (178)Tj ET endstream endobj 106 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (4.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\231\b\240\002\217\002\b\002\n\006\004\226\t\201\r\217\220\002\r \t\217\217\ \f\r\240\002\004\b\t\r \(\231\222\255\))Tj -1.352 -1.218 Td (\037\r\f\001: )Tj /T1_2 1 Tf 0.015 Tw 2.704 0 Td (\031\f\021\026\027\024\r\017\021\034 \f\035\024\005 \024\002\030\026\024\ \r\026\027\017\016, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \024\027\024 )Tj 0 Tw -2.704 -1.218 Td (\017\f\b\024\007\017\021, \036\020\024 \f\021\030\031\022\021\031\030\031\ \017)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\020\036\027\027\024\f\021\034.)Tj /T1_1 1 Tf 0 -1.218 TD (\017\217\b\002\b\013\r \212\006\t\213\b\004\220\t \f\t\212\002\214\013:\ )Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\206\017\023\036\030\220\b\024\020\036\027\027\026\016 \024\007\027\024\030\ \024\007\027\026\016 \f\021\030\031\022\021\031\030\026.)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\230\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024\ \f\035\024\005\).)Tj -0.233 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\232\036\021\022\017\036 )-233(\020\030\026\027\017\006\t.)]TJ -0.024 Tw T* (\226)Tj /Span<>> BDC [( )-291( )]TJ EMC 1.056 0 Td (\222\r\024\002\024\007\027\026\016 \022\024\n\023\030\036\f\f\017\016 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\026\r\035\017\r\026\027\017\017 \007\017\f\021\026\035\034)Tj 0 Tw (-)Tj T* (\027\t\n \022\024\027\006\024\n \220\b\024\220\027\007\024\f\022\024\023\ \026.)Tj /T1_1 1 Tf -1.056 -1.218 Td (\033\b\004\201\t\214\013\r \212\004\006\004\214\r\003\006\013:)Tj /T1_2 1 Tf 0.029 Tw T* (\226)Tj /Span<>> BDC [( )-238( )]TJ EMC 1.056 0 Td [(\215\036\030\r\t\005 \f\035\024\005: \206\017\023\036\030\220\b\024\020\036\ \027\027\t\005 )0.5(\(\f\035\017\017\f\021\026\016 )0.5(\024\002\024\035\024\004)]TJ 0 Tw (-)Tj T* (\022\026\), \017\027\021\026\022\021\027\t\005.)Tj 0.092 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-175( )]TJ EMC 1.056 0 Td (\200\021\024\030\024\005 \f\035\024\005: \206\017\023\024\220\b\024\020\036\ \027\027\t\005 \(\n\t\001\036\004\027\026\016 \023\035\026\f\021\017\027\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\022\026 \f\035\017\017\f\021\024\005\), \017\027\021\026\022\021\027\t\ \005.)Tj -0.015 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-282( )]TJ EMC 1.056 0 Td (\221\030\036\021\017\005 \f\035\024\005: \206\017\023\036\030\220\b\024\020\ \036\027\027\t\005 \(\023\024\007\f\035\017\017\f\021\t\005 \f\035\024\005\ , )Tj 0 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \017\f\b\024\007\017\021 \035\017\023\024\ \n\026\).)Tj 0.179 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-88( )]TJ EMC 1.056 0 Td [(\232\036\021\r\036\030\021\t\005 \f\035\024\005: \206\017\023\024\220\b\024\ \020\036\027\027\t\005 )0.5(\(\n\t\001\036\004\027\026\016 )0.5(\024\002\024)]TJ 0 Tw (-)Tj T* (\035\024\004\022\026\), \017\027\021\026\022\021\027\t\005.)Tj -0.018 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-285( )]TJ EMC 1.056 0 Td [(\215\016\021\t\005 \f\035\024\005: \206\017\023\036\030\220\b\024\020\036\ \027\027\t\005 )0.5(\(\f\036\030\024\027\026\016 \024\002\024\035\024\004\022\026\), )]TJ 0 Tw T* (\017\027\021\026\022\021\027\t\005.)Tj /T1_1 1 Tf -1.056 -2.436 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\031\t\226\226\r\006\r\b\204\t\004\f\001\b\004\235 \240\t\004\n\b\002\217\ \003\t\220\004)Tj -1.352 -1.218 Td (\037\r\f\001: )Tj /T1_2 1 Tf 0.261 Tw 2.95 0 Td (\024\021\035\017\004\017\021\034 \035\017\023\024\n\031 \024\021 \007\030\ \031\020\017\b \017\027\021\030\026\n\031\030\026\035\034\027\t\b )Tj 0 Tw -2.95 -1.218 Td (\024\002\030\026\024\r\026\027\017\005)Tj /T1_1 1 Tf T* (\215\r\003\002\240\013 \217\006\004\b\r\b\t\235:)Tj /T1_2 1 Tf 0.03 Tc 0.267 Tw T* (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf -0.03 Tw 1.116 0 Td (\027\034\255\017: )Tj /T1_2 1 Tf 0.533 Tw 3.45 0 Td [(\206\017\023\024\220\b\024\020\036\027\027\t\036 )0.5(\024\002\030\026\024\r\026\027\017\016, )0.5(\017\f\b\024\007\016)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.5 Tw -3.45 -1.218 Td (\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC [(2/4 \220\b\024\f\035\024\016; \r\024\n\024\032\027\t \220\b\024\020\036\ \027\027\t\036)30( )]TJ -0.03 Tw T* (\r\022\035\033\004\036\027\017\016.)Tj 0 Tc 0.267 Tw -1.116 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\035\r\005\002\214\t\002\214\004: )Tj /T1_2 1 Tf 0.03 Tw 5.505 0 Td (\206\017\023\024\220\b\024\020\036\027\027\t\036 \024\002\030\026\024\r\ \026\027\017\016, \017\f\b\024\007\016)Tj 0 Tw (-)Tj -5.505 -1.218 Td (\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (2 \017\035\017 4 \220\b\024\f\035\024\016; \020\024\n\024\020\036\027\027\ \026\016 \f\021\030\031\022\021\031\030\026.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\016\004\b\b\002\214\004: )Tj /T1_2 1 Tf 0.16 Tw 5.246 0 Td [(\206\017\023\024\220\b\024\020\036\027\027\t\036 )0.6(\024\002\030\026\024\r\026\027\017\016, )0.6(\017\f\b\024\007\016)]TJ 0 Tw (-)Tj 0.043 Tw -5.246 -1.218 Td (\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (2 \017\035\017 3 \220\b\024\f\035\024\016; \021\030\036\002\031\036\021 \ \020\017\f\021\024\035\024\020\017\004\036\f\022\024\020\024 )Tj 0 Tw T* (\026\027\026\035\017\026 \007\035\016 \021\024\004\027\024\005 \017\007\ \036\027\021\017\235\017\022\026\006\017\017.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\025\231\017: )Tj /T1_2 1 Tf 0.09 Tw 2.348 0 Td (\222\030\036\007\027\036\023\024\027\017\032\036\027\027\026\016 \017\035\ \017 \017\024\220\b\024\020\036\027\027\026\016 \f\021\030\031\022)Tj 0 Tw (-)Tj -2.348 -1.218 Td (\021\031\030\026, \004\036\021\022\017\036 \022\024\027\021\031\030\t; \017\ \f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (2 \017\035\017 3 \220\b\024\f\035\024\016.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\026\203\200: )Tj /T1_2 1 Tf -0.024 Tw 2.442 0 Td (\206\017\023\024\220\b\024\020\036\027\027\t\036 \024\002\030\026\024\r\ \026\027\017\016, \017\f\b\024\007\016\013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (2 )Tj 0 Tw -2.442 -1.218 Td (\017\035\017 3 \220\b\024\f\035\024\016; \027\036\004\036\021\022\017\036\ \022\024\027\021\031\030\t.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\032\200\207: )Tj /T1_2 1 Tf -0.02 Tw 2.526 0 Td (\206\036\021\036\030\024\020\036\027\027\026\016 \f\021\030\031\022\021\031\ \030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\017\n\017 \020\017\023\036\030\220\b\024)Tj 0 Tw (-)Tj -0.022 Tw -2.526 -1.218 Td (\020\036\027\027\t\n\017 \r\022\035\033\004\036\027\017\016\n\017, \027\026\ \035\017\004\017\036 \023\030\024\021\024\022\024\r\024\005 \f\017\f\021\ \036)Tj 0 Tw (-)Tj T* (\n\t; \017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (3 \017\035\017 4 \220\b\024\f\035\024\016.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.276 Tw 1.056 0 Td (\031\210\212\f\t\220\004\204\t\002\b\b\013\r \220\t\217\003\013: )Tj /T1_2 1 Tf (\206\024\n\024\020\036\027\027\t\036 \026\027\220\b\024\020\036\027)Tj 0 Tw (-)Tj 0.187 Tw T* (\027\t\036 \017\035\017 \020\017\023\024\220\b\024\020\036\027\027\t\036\ \024\002\030\026\024\r\026\027\017\016, \017\f\b\024\007\016\013\017\036\ )Tj 0.18 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (3 \220\b\024\f\035\024\016; \002\036 \022\030\024\r\024\021\024\022\026\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\023\035\036\030\024\r\f\022\024\n )Tj 0 Tw T* (\f\022\026\027\017\030\024\r\026\027\017\017.)Tj /T1_1 1 Tf 0.043 Tw -1.056 -2.436 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\215\002\006\226\002\f\002\n\t\201\r\217\220\004\235 \r\006\t\226\t\220\ \004\204\t\235 \(\212\006\t \212\002\240\002\213\006\r)Tj 0 Tw (-)Tj -1.352 -1.218 Td (\b\t\t \b\004)Tj /Span<>> BDC ( )Tj EMC (\213\f\002\220\004\201\r\217\003\r\b\b\002\r \212\r\006\r\006\002\202\240\ \r\b\t\r\))Tj T* (\215\r\003\002\240\013:)Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\264\017\023\006\024\r\026\016 \(\r \021.\004. \f\021\031\023\036\027\004\ \026\021\026\016\) \002\017\024\023\f\017\016.)Tj 0.183 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-84( )]TJ EMC 1.056 0 Td (\207\017\024\023\f\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\r\026\030\017\021\036\035\034\027\t\n \030\026\030\036\ \024\n \f\035\017\017\f\021\024\005 )Tj 0 Tw T* (\024\002\024\035\024\004\022\017.)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\221\024\027\022\024\017\020\024\035\034\027\026\016 \002\017\024\023\f\017\ \016 \023\024\007 \022\024\027\021\030\024\035\036\n \233\211\222-\221\230\ \215.)Tj 0.449 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )182( )]TJ EMC 1.056 0 Td (\215\024\035\027\024\036 \031\007\026\035\036\027\017\036 \024\002\030\026\ \024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\005 )Tj 0 Tw T* (\020\017\f\021\024\035\024\020\017\036\005.)Tj /T1_1 1 Tf 22.188 64.543 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\022\r\230\r\b\t\r \002)Tj /Span<>> BDC ( )Tj EMC (\003\004\220\003\t\220\r \f\r\201\r\b\t\235)Tj -0.01 Tw -1.352 -1.218 Td [(\036\217\f\t \f\t\212\002\214\004 \240\002\206\006\002\220\004\201\r\217\ \003\r\b\b\004\235 )0.5(\(\212\002 \240\004\b\b\013\214 \231\222\255\):)]TJ /T1_2 1 Tf 0.071 Tw T* (\226)Tj /Span<>> BDC [( )-196( )]TJ EMC 1.056 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (10 \n\n )Tj /C2_0 1 Tf 0 Tw <013A>Tj /T1_2 1 Tf 0.071 Tw ( \022\024\027\021\030\024\035\034\027\026\016 \233\206\212\222 \004\036\030\ \036 )Tj 0 Tw T* (2\2263 \020\024\007\026.)Tj -0.036 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-303( )]TJ EMC 1.056 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b 10\22620 \n\n )Tj /C2_0 1 Tf 0 Tw <013A>Tj /T1_2 1 Tf -0.036 Tw ( \022\024\027\021\030\024\035\034\027\026\016 \233\206\212\222 \004\036\030\ \036 )Tj 0 Tw T* (1\2262 \020\024\007\026.)Tj 0.082 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-185( )]TJ EMC 1.056 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 1.936 0 Td (\030\026\n\036\030\026\b)Tj /Span<>> BDC ( )Tj EMC 4.154 0 Td (>)Tj /Span<>> BDC ( )Tj EMC [(20 )0.5(\n\n \017\035\017 )0.5(\027\026\035\017\004\017\017 )0.5(\f\017\n\023\021\024\n\024\r )]TJ /C2_0 1 Tf 0 Tw 13.965 0 Td <013A>Tj /T1_2 1 Tf ( )Tj -20.054 -1.218 Td (\031\007\026\035\036\027\017\036.)Tj /T1_1 1 Tf 2.886 Tw -1.056 -1.218 Td (\036\217\f\t \212\002\240\002\213\006\r\004\r\003\217\235 \213\f\002\220\ \004\201\r\217\003\r\b\b\002\r )Tj 0 Tw T* (\212\r\006\r\006\002\202\240\r\b\t\r:)Tj /T1_2 1 Tf 0.05 Tw T* (\226)Tj /Span<>> BDC [( )-217( )]TJ EMC 1.056 0 Td (\230\f\023\024\035\034\024\r\026\027\017\036 \007\024\023\024\035\027\017\ \021\036\035\034\027\t\b \n\036\021\024\007\024\r \007\017\026\020\027\024\ \f)Tj 0 Tw (-)Tj T* (\021\017\022\017 \(\204\222\025\221, \204\217\221, \007\024\023\023\035\036\ \030\024\r\f\022\024\036 \f\022\026\027\017\030\024\r\026\027\017\036\).\ )Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\216\017\030\031\030\020\017\004\036\f\022\024\036 \017\035\017 \220\027\ \007\024\f\022\024\023\017\004\036\f\022\024\036 \031\007\026\035\036\027\ \017\036.)Tj /T1_1 1 Tf -1.056 -2.436 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\215\r\003\002\240\013 \210\240\004\f\r\b\t\235 \f\t\212\002\214\013)Tj -1.352 -1.218 Td (\231\b\240\002\217\220\002\212\t\201\r\217\220\t\r \214\r\003\002\240\013\ :)Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\217\036\036\022\006\017\016 \f\035\017\017\f\021\024\005 \024\002\024\ \035\024\004\022\017 \(EMR\).)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\212\017\f\f\036\022\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \(ESD\).)Tj 1.748 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )1481( )]TJ EMC 1.056 0 Td [(Hybr)-37(id-\n\036\021\024\007 p)25(r)-23.9(ecut-EMR \007\035\016 \f\035\024\032\027\024\005 )]TJ 0 Tw T* (\035\024\022\026\035\017\026\006\017\017.)Tj /T1_1 1 Tf -1.056 -1.218 Td (\225\t\006\210\006\n\t\201\r\217\220\t\r \214\r\003\002\240\013:)Tj /T1_2 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\221\024\030\026\022\024\f\022\024\023\017\004\036\f\022\017\036 \024\023\ \036\030\026\006\017\017 \(\007\035\016 \023\017\013\036\r\024\007\026\)\ .)Tj 0.951 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )684( )]TJ EMC 1.056 0 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\036 \024\023\ \036\030\026\006\017\017 \(\007\035\016 \032\036\035\031\007\022\026 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\017\022\026\).)Tj 0.031 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-236( )]TJ EMC 1.056 0 Td [(\210\021\022\030\t\021\t\036 \024\023\036\030\026\006\017\017 \(\023\030\ \017 )0.5(\027\036\r\024\n\024\032\027\024\f\021\017 \220\027\007\024\f\022\024)]TJ 0 Tw (-)Tj T* (\023\017\004\036\f\022\024\020\024 \007\024\f\021\031\023\026\).)Tj /T1_1 1 Tf -1.056 -2.436 Td (\021\f\211\201\r\013\r \230\004\n\t \004\f\n\002\006\t\003\214\004:)Tj 0.125 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\231\027\031\255/\021\255 )Tj /Span<>> BDC ( )Tj EMC (\206\r\f\002\214 \217\r\003\r)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 10.576 0 Td <013A>Tj /T1_2 1 Tf 0.125 Tw ( \210\023\030\036\007\036\035\036\027\017\036 \235\024\030\n\t, )Tj 0 Tw -11.928 -1.218 Td (\006\r\036\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\017\f\021\036\027\006\017\017 \024\002\030\026\024\r\026\ \027\017\016.)Tj /T1_1 1 Tf 0.179 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\200\004\f\001\212\004\003\002\006\b\013\r \003\r\217\003\013)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 9.674 0 Td <013A>Tj /T1_2 1 Tf 0.179 Tw ( \215\024\007\021\r\036\030\032\007\036\027\017\036 \n\016\020\022\024)Tj 0 Tw (-)Tj -11.026 -1.218 Td (\f\021\017, \253\f\017\n\023\021\024\n \023\024\007\031\001\022\017\273,\ \253\f\017\n\023\021\024\n \001\026\021\030\026\273.)Tj /T1_1 1 Tf 0.267 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC (\231\222\255)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 3.297 0 Td <013A>Tj /T1_2 1 Tf 0.185 Tw [( )0.5(\210\006\036\027\022\026 )0.5(\f\035\024\016, )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.65 0 Td [(\022\024\021\024\030\024\020\024 )0.5(\017\f\b\024\007\017\021 )0.6(\024\002\030\026)]TJ 0 Tw (-)Tj 0.225 Tw -11.947 -1.218 Td [(\024\r\026\027\017\036 \(3 \220\b\024\f\035\024\005\), \220\b\024\020\036\ \027\027\024\f\021\017 )0.5(\(\020\017\023\036\030\220\b\024\020\036\027\027\026\016, )]TJ 0 Tw T* (\024\007\027\024\030\024\007\027\026\016 \f\021\030\031\022\021\031\030\026\ \).)Tj /T1_1 1 Tf 0.154 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\031\t\226\226\r\006\r\b\204\t\004\f\001\b\004\235 \240\t\004\n\b\002\217\ \003\t\220\004)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 14.991 0 Td <013A>Tj /T1_2 1 Tf 0.154 Tw ( \222\030\026\r\027\036\027\017\036 )Tj 0 Tw -16.343 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\n\017 \017\027\021\030\026\n\031\030\026\035\034\027\ \t\n\017 \024\002\030\026\024\r\026\027\017\016\n\017.)Tj /T1_1 1 Tf 0.237 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\215\002\006\226\002\f\002\n\t\201\r\217\220\004\235 \r\006\t\226\t\220\ \004\204\t\235)Tj /T1_2 1 Tf 0 Tw ( )Tj /C2_0 1 Tf 14.849 0 Td <013A>Tj /T1_2 1 Tf 0.237 Tw ( \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\024)Tj 0 Tw (-)Tj -16.201 -1.218 Td (\030\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\004\036\f\021\r\036\027\027\024\036 \023\036\030\036\030\ \024\032\007\036\027\017\036.)Tj /T1_1 1 Tf T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\025\004\206\f\211\240\r\b\t\r \t\f\t \f\r\201\r\b\t\r)Tj /T1_2 1 Tf (:)Tj 0.267 Tw -1.352 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\025\004\206\f\211\240\r\b\t\r: )Tj /T1_2 1 Tf 0.317 Tw 6.369 0 Td (\007\035\016 \002\036\f\f\017\n\023\021\024\n\027\t\b \035\017\023\024\n\ \n\026\035\t\b )Tj 0 Tw -6.369 -1.218 Td (\030\026\n\036\030\024\r.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw 1.056 0 Td (\222\240\004\f\r\b\t\r: )Tj /T1_2 1 Tf 0.371 Tw 5.078 0 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (2 \f\n \017\035\017 \027\026\035\017\004\017\017 )Tj 0 Tw -5.078 -1.218 Td (\f\017\n\023\021\024\n\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 164.6418 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.174 Tw 10 0 0 10 274.9606 140.2858 Tm (\214\017\023\024\n\t \032\036\035\031\007\024\004\027\024-\022\017\001\036\ \004\027\024\020\024 \021\030\026\022\021\026 \016\r\035\016\033\021\f\016\ \024\007)Tj 0 Tw (-)Tj -0.014 Tw T* [(\027\017\n\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.5 0 Td [(\027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\024 )0.5(\r\f\021\030\036\004\026\033\013\017\b\f\016 )0.6(\024\002\030\026\024\r\026\027\017\005 )]TJ 0.139 Tw -3.5 -1.218 Td (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ \021\030\026\022\021\026. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 )Tj 0.072 Tw T* (\023\026\021\024\020\027\024\n\024\027\017\004\027\t\b \023\030\017\027\ \026\022\024\r, \023\024\r\024\035\016\033\013\017\b \022\024\030\030\036\ \022\021)Tj /Span<>> BDC (-)Tj EMC 0.185 Tw T* (\027\024 \023\024\f\021\026\r\017\021\034 \007\017\026\020\027\024, \023\ \030\017\n\036\027\036\027\017\036 \007\024\023\024\035\027\017\021\036\035\ \034\027\t\b )Tj 0.266 Tw T* (\n\036\021\024\007\024\r \024\002\f\035\036\007\024\r\026\027\017\016, \021\ \026\022\017\b \022\026\022 \220\027\007\024\f\024\027\024\020\030\026\235\ \017\016, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 505.6144 56.0378 Tm (177)Tj ET endstream endobj 104 0 obj <> endobj 276 0 obj [278 0 R] endobj 277 0 obj <>stream H\j0 ~ Cq !PZ9dE6sWqC O|4׆|0EpimG]cC}PU&xمJC4As8"%8B]^nFCDi9Z"BS4Ѐ:JPJ 7aq/gqũ}{ egfɓw> endobj 279 0 obj <> endobj 280 0 obj <> endobj 281 0 obj <>stream Hj` (H endstream endobj 282 0 obj <>stream HWwNWݿs`S4A%D$y+"ě ["_PRD)z"eQe״aU;7m%V5jK3;f V^7~޳>P 1tdxYr)f.xyq'#77HfnRF^<@_xO̴sb=|L^h8q*3o;sȒDMI( .s< a8-97m7|"<<{V~GhQރ@7#]5K(T-ǜ:<0jpl bh8n.b Z>]lՌ_yM{MwTymnlBKsi|",#(WüBO A2JC16yT[vG[ $-%ORO:F)#s1/72z؁)_3ZhD8Ir9oowm0 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Uɗ<_0='A |{ZUJ/RNj$I.L߿jy7#Q]S Bg 7ýW}}ߤRׂ>0Js"GZo2'ch;MW qmGRb/f7BL޷ gf`8b)g}pއ< CN{5.=TPJ|a0tk:pZ1An1 +*oR;iq.7YHr.]@RsU.^%%R-8Fɾ!6NDEntM1IQ.v:Qi63e3k|EN V_Kkvxq#5}/с;oe^x7Χ=Ɵv(7&'1 )ZJSb)c:_Wر|î]Uo(x~syyyyyY3-y%ײcX-&b!촧wmmlm"$.rZzbJck M5ƶDUyc<ےXޘ4}үwP0 $OJ+O>ASإ%b'9;&5KKZ@2\賤ϒšĹvcåK5 l΢ݘڪ}}R9Dj'IrE鳵HEq aIR"H M0 ZRW;QRz֋ kNzwuה]ÞuRW+:$غB<&,"8e=Rs2Cj? eᤳvN(>`(x~^ku|HPD3IZȦwgR 7 q~y{ CfpJ3B uǰi{@`SВ[J+1]tsӐJ#1TrS J!W1,*bN1AzSOjZmmG}P:-+miGړ0VumG!v"C3h0\D<]q WtncQUP Ǩ|H_!ˇ³!>'+ .b/a.xL8|(g"K<+&i AZO%!򳆈"Y>[ z*Qm8pS2 XG PMa k`T@i~`y+1c֪%xRQ~||JQA\Gy* Ӣ'S}Z4;)WOҗ< vE^|- @zQ0D[ endstream endobj 103 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.072 Tw 10 0 0 10 70.8661 724.8299 Tm (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td [(\020\024\n\024\020\036\027\027\024\036 \020\017\023\024\220\b\024\020\036\ \027\027\024\036 )0.5(\017\035\017 \026\027\220\b\024\020\036\027\027\024\036 )0.5(\024\002\030\026)]TJ 0 Tw (-)Tj -1 -1.218 Td (\024\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 \022\024\027\021\031\030\026\n\017;)Tj 0.244 Tw 0 -1.218 TD (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024\ \f\035\024\005\) \017\035\017 )Tj 0.445 Tw -1 -1.218 Td (\030\026\f\023\024\035\026\020\026\036\021\f\016 \r\027\036 \024\030\020\ \026\027\024\r \240\025\221. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\035\036\030\024\r)Tj 0 Tw (-)Tj 0.662 Tw T* [(\f\022\024\n \f\022\026\027\017\030\024\r\026\027\017\017 )0.5(\022\030\024\r\024\021\024\022 \027\036 \024\023\030\036\007\036\035\016\ \036\021\f\016. )]TJ 0.267 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\f\021\017 \022\017\f\021\t \n\024\020\031\021 \024\023\030\ \036\007\036\035\016\021\034\f\016 \023\036\030\036\020\024\030\024\007\022\ \017, )Tj 0.402 Tw 0 -1.218 TD (\023\030\024\f\035\036\032\017\r\026\036\021\f\016 \023\036\030\017\f\021\ \026\035\034\021\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \022\024\035\034\006\036\r\t\b )Tj 0 Tw 0 -1.218 TD (\f\024\022\030\026\013\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC ([54\22656].)Tj -0.042 Tw T* (\212\017\026\020\027\024\f\021\017\022\026 \007\026\027\027\024\005 \023\ \026\021\024\035\024\020\017\017 \r\022\035\033\004\026\036\021 \r\t\023\ \024\035\027\036\027\017\036 )Tj -0.045 Tw T* (\025\221 \(\023\030\036\007\023\024\004\021\017\021\036\035\034\027\024 \ \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\r\036\027\027\t\n \022\024\027\021\030\026\f\021\017\ \030\024\r\026)Tj 0 Tw (-)Tj 0.098 Tw T* (\027\017\036\n\), \204\217\221, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\ \036 \017\f\f\035\036\007\024\r\026\027\017\036, )Tj 0.139 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017 \233\211\222, \023\024\r\024\035\016\033\ \013\036\036 \024\023\030\036\007\036\035\017\021\034 \b\026\030\026\022\ \021\036\030 )Tj 0.077 Tw 0 -1.218 TD [(\024\002\030\026\024\r\026\027\017\016 \(\022\017\f\021\024\027\024\036\ )0.5(\017\035\017 \f\024\035\017\007\027\024\036\), \023\026\021\024\035\024\020\ \017\004\036)]TJ 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\f\022\017\036 \017\n\036\027\036\027\017\016 \f\035\017\017\f\021\024\ \005 \024\002\024\035\024\004\022\017 [56]. \217\024\035\034 \233\211\222\ -)Tj 0.273 Tw 0 -1.218 TD (\221\230\215 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \007\031\023\035\017\022\026\006\ \017\024\027\027\t\b \022\017\f\021 \024\f\021\026\036\021\f\016 )Tj 0.164 Tw T* (\f\023\024\030\027\024\005, \021\026\022 \022\026\022 \004\026\f\021\024\ \021\026 \017\027\235\017\006\017\030\024\r\026\027\017\016 \007\024\f\021\ \017\020\026\036\021 )Tj 0 Tw T* (14% [57].)Tj /T1_1 1 Tf 0.163 Tw T* (\031\t\004\n\b\002\217\003\t\201\r\217\220\t\005 \004\f\n\002\006\t\003\214\ \234\b\240\002\217\220\002\212\t\201\r\217\220\002\n\002 \t\217)Tj 0 Tw (-)Tj T* (\217\f\r\240\002\004\b\t\235 \f\t\212\002\214 \207\021\020 )Tj /T1_0 1 Tf (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (11\))Tj /T1_1 1 Tf 0.159 Tw 0 -2.436 TD (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\025\004\201\004\f\001\b\013\005 \234\003\004\212: \026\t\213\210\004\f\t\ \213\004\204\t\235 )Tj /Span<>> BDC ( )Tj EMC (\206\r\f\002\214 \217\r\003\r )Tj 0 Tw -1.352 -1.218 Td (\(\231\027\031\255/\021\255\))Tj 0 -1.218 TD (\037\r\f\001: )Tj /T1_0 1 Tf -0.012 Tw 2.676 0 Td [(\024\023\030\036\007\036\035\017\021\034 )0.6(\n\026\022\030\024\f\022\024\023\017\004\036\f\022\017\036 )0.6(\b\026\030\026\022\021\036\030\017\f\021\017\022\017 )]TJ 0 Tw -2.676 -1.218 Td (\024\002\030\026\024\r\026\027\017\016.)Tj /T1_1 1 Tf T* (\017\217\b\002\b\013\r \212\006\t\213\b\004\220\t:)Tj /T1_0 1 Tf T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\215\024\035\031\f\235\036\030\017\004\036\f\022\026\016 \017\035\017 \023\ \024\035\031\024\r\024\017\007\027\026\016 \235\024\030\n\026.)Tj 1.63 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )1363( )]TJ EMC 1.056 0 Td [(\203\036\017\n\036\027\201\027\027\026\016 )0.6(\f\035\017\017\f\021\026\016 )0.5(\024\002\024\035\024\004\022\026 )0.5(\027\026\007 )]TJ 0 Tw T* (\024\002\030\026\024\r\026\027\017\036\n.)Tj 0.862 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )595( )]TJ EMC 1.056 0 Td (\240\036\035\021\024\r\026\021\t\005 \024\021\021\036\027\024\022 \(\f\023\ \036\006\017\235\017\004\027\t\005 \023\030\017\027\026\022 )Tj 0 Tw T* (\035\017\023\024\n\t\).)Tj -0.233 Tw 22.188 35.316 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\204\016\020\022\026\016 )-232.9(\022\024\027\f\017\f\021\036\027\006\017\016.)]TJ /T1_1 1 Tf 0 Tw 0 -2.436 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\017\204\r\b\220\004 \006\004\213\214\r\006\002 \t)Tj /Span<>> BDC ( )Tj EMC (\214\r\217\003\002\212\002\f\002\202\r\b\t\235)Tj -1.352 -1.218 Td (\215\r\003\002\240\013:)Tj /T1_0 1 Tf 0.025 Tw 0 -1.218 TD (\226)Tj /Span<>> BDC [( )-242( )]TJ EMC 1.056 0 Td (\233\024\235\026\020\024\020\026\f\021\030\024\007\031\024\007\036\027\024\ \f\022\024\023\017\016 \(\233\206\212\222\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \023\017\013\036)Tj 0 Tw (-)Tj T* (\r\024\007\026, \032\036\035\031\007\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\017.)Tj -0.029 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-296( )]TJ EMC 1.056 0 Td (\025\024\035\024\027\024\f\022\024\023\017\016 \(\025\222\))Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \021\024\035\f\021\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\027\022\024\005 \022\017\001\024\022.)Tj /T1_1 1 Tf 0 Tw -1.056 -1.218 Td (\026\004\202\b\013\r \214\002\214\r\b\003\013:)Tj /T1_0 1 Tf -0.021 Tw T* (\226)Tj /Span<>> BDC [( )-288( )]TJ EMC 1.056 0 Td (\213\f\035\017 \030\026\n\036\030)Tj /Span<>> BDC ( )Tj EMC 5.268 0 Td (\234)Tj /Span<>> BDC ( )Tj EMC (2 \f\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\021 \f\017\n\023\021\024\n\024\r )Tj /C2_0 1 Tf 0 Tw 9.606 0 Td <013A>Tj /T1_0 1 Tf -0.021 Tw ( \023\030\024\007\024\035\032\017\021\034 )Tj 0 Tw -14.874 -1.218 Td (\027\026\002\035\033\007\036\027\017\036.)Tj 0.199 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-68( )]TJ EMC 1.056 0 Td (\213\f\035\017 \030\026\n\036\030)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (2 \f\n \017\035\017 \023\030\017\f\031\021\f\021\r\031\033\021 \f\017\n\023\ \021\024\n\t )Tj 0.518 Tw T* [(\(\002\024\035\034, )0.6(\017\027\r\026\020\017\027\026\006\017\016, )0.5(\024\002\f\021\030\031\022\006\017\016, )0.5(\022\030\024\r\024\021\036\004\036\027\017\036, )]TJ 0 Tw 0 -1.218 TD (\017\255\016\r\035\036\027\017\036\) )Tj /C2_0 1 Tf <013A>Tj /T1_0 1 Tf ( \023\036\030\036\005\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\036\n\031 \220\021\026\023\031.)Tj /T1_1 1 Tf 0.122 Tw -1.056 -2.436 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\200\004\f\001\212\004\003\002\006\b\013\r \003\r\217\003\013 \240\f\235\ \210\003\002\201\b\r\b\t\235 \216\004\006\004\220\003\r\006\004 )Tj 0 Tw -1.352 -1.218 Td (\002\206\006\004\213\002\004\b\t\235)Tj 0 -1.218 TD (\215\r\003\002\240\013:)Tj /T1_0 1 Tf 0.054 Tw T* (\226)Tj /Span<>> BDC [( )-213( )]TJ EMC 1.056 0 Td (\230\027\f\021\030\031\n\036\027\021\026\035\034\027\026\016 \253\023\026\ \035\034\023\026\006\017\016\273 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n )Tj 0 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \002\017\024\023\f\ \017\005\027\t\b \013\017\023\006\024\r.)Tj /T1_1 1 Tf -1.056 -1.218 Td (\200\006\t\213\b\004\220\t:)Tj /T1_0 1 Tf 0.267 Tw T* (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.522 Tw 1.056 0 Td [(\255\t\214\212\003\002\214 )0.5(\212\002\240\210\230\220\t)]TJ /T1_0 1 Tf [(: )0.5(\235\024\030\n\017\030\024\r\026\027\017\036 )0.6(\031\020\035\031\002\035\036\027\017\016 )]TJ 0.294 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\036\030\b\027\024\f\021\017 \024\002\030\026\024\r\026\027\017\ \016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\027\026\007\026\r\035\017\r\026\027\017\017 )Tj -0.086 Tw T* (\(\f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 98%, \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 40%\).)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.085 Tw 1.056 0 Td (\255\t\214\212\003\002\214 \230\004\003\006\004)Tj /T1_0 1 Tf [(: \235\024\030\n\017\030\024\r\026\027\017\036 \021\030\036\031\020\024\035\ \034\027\024\005 )0.5(\253\023\026)]TJ 0 Tw (-)Tj 0.08 Tw T* [(\035\026\021\022\017/\001\026\021\030\026\273 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.268 0 Td [(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\027\026\007 )0.5(\023\024\r\036\030\b)]TJ 0 Tw (-)Tj -7.268 -1.218 Td (\027\024\f\021\034\033 \024\002\030\026\024\r\026\027\017\016 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\036\201 \021\030\026\022\006\017\017.)Tj 0.267 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.138 Tw 1.056 0 Td (\255\t\214\212\003\002\214 \002\206\b\004\202\t\230\r\n\002\217\235 \202\ \t\006\004)Tj /T1_0 1 Tf (: \r\t\f\r\024\002\024\032\007\036\027\017\036 )Tj 0.237 Tw T* (\032\036\035\021\024\005 \032\017\030\024\r\024\005 \021\022\026\027\017\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \f\021\031\023\036\027)Tj 0 Tw (-)Tj 0.151 Tw T* (\004\026\021\024\005 \002\017\024\023\f\017\017 \(\n\024\032\036\021 \002\ \t\021\034 \030\036\026\035\017\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 )Tj 0 Tw T* (\027\036\024\002\b\024\007\017\n\024\f\021\017\).)Tj ET q 70.866 122.57 453.543 226.461 re W n q /GS0 gs 453.543294 0 0 226.531677 70.8661346 122.499573 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 111.7701 Tm (\022\t\217\210\b\002\220 11.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\200\027\026\020 \030\022\020\b\025\031\024\023\022\007\027\024\n\031\ \b\031 \020\f\b\031\032\022\023\026\020 \204\025\030\031\024\n\031\033\022\ \007\027\024\n\031\b\031 \022\024\024\f\027\030\031\021\020\025\022\t \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\020\n\023\022\n\022 \021\027\030\027\025\022\t \f\022\033\031\026 \234\ \202)Tj 0 -1.2 TD (\004\032\022\026\027\007\020\025\022\027: *)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\240\200\031\030\022\026\031\024\023\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf T* [(F)-16(igure 1)158.1(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Illustration of)Tj /Span<>> BDC ( )Tj EMC [(the diagnostic algor)-36.7(ithm for endoscopic e)-14.8(x)10(amination and manag)12(ement of)]TJ /Span<>> BDC ( )Tj EMC [(g)12(astrointestinal lipomas)]TJ T* [(N)17(o)13(te: *)]TJ /Span<>> BDC ( )Tj EMC [(\227 if necessar)-42.8(y)32(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.84 56.0378 Tm (176)Tj ET endstream endobj 105 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  z !"1Q3ARq#$Ca %&'()*2456789:BDEFGHIJSTUVWXYZbcdefghijrstuvwxyz u!1AQaq"25RTbsBS %3 #$&'()*46789:CDEFGHIJUVWXYZcdefghijrtuvwxyz?@mzP krn.U!ROT׸{o?Vô,ݙ2fR\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`R\~K`U}9՝5M''j7j2oV6f?MXе@/7f~̥Yk i~Y3e/sXl*78*WIZ~f}.mm'B;ZWzu(uJ 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sғVnc9zd%))Xvmi:sQKS߭x1/3O[ݔlݞNXI`Z{1/3%J{Oȗ#'폖[o#(c;=Ե@ T)miiTVz&U}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}ZW>{ie w^էe{CVR}Zh핢Si8KXʬl 6ݧf)ENroDu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.+=1h|_@ﲽOu?.K6&Yӫ6~Lcfv[5j%%fNPmrn-iO{=??W{~SvO|flodzݭz?g[>1k|^kiO{=??W{~SvO|flodzݭz?g[>1k|^kiO{=??W{~SvO|flodzݭz?g[>1k|^kiO{=??WsIJsnRmɻ[o endstream endobj 283 0 obj <>stream endstream endobj 102 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.09 Tw 10 0 0 10 42.5197 724.8299 Tm (\025\035\036\021\022\017 \001\r\026\027\027\024\n\t \220\022\f\023\030\036\ \f\f\017\030\031\033\021 \002\036\035\024\022 S-100, SD57, )Tj 0.131 Tw 0 -1.218 TD (SD56 \017)Tj /Span<>> BDC ( )Tj EMC [(GF)24(AP \(\020\035\017\026\035\034\027\t\005 \235\017\002\030\017\035\035\016\ \030\027\t\005 \022\017\f\035\t\005 \002\036)]TJ 0 Tw (-)Tj 0.016 Tw T* (\035\024\022\), \021\026\022\032\036 \007\035\016 \024\006\036\027\022\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\026 \023\030\024\035\017\235\036\030\026\021\017\ \r\027\024\005 )Tj 0.095 Tw T* (\026\022\021\017\r\027\024\f\021\017 \017\f\f\035\036\007\031\036\021\f\016\ Ki-67. \206\017\f\021\024\035\024\020\017\004\036\f\022\026\016 \022\026\ \030)Tj 0 Tw (-)Tj 0.036 Tw T* (\021\017\027\026 \001\r\026\027\027\024\n\t \023\030\036\007\f\021\026\r\ \035\016\036\021 \f\024\002\024\005 \r\036\030\036\021\036\027\024\022\035\ \036\021\024\004)Tj 0 Tw (-)Tj 0.07 Tw T* (\027\t\036 \024\023\031\b\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\017\004\027\t\b \f\035\031\004\026\016\b \f\024\f\021\024\016\ \013\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b )Tj 0.219 Tw 0 -1.218 TD (\022\024\n\023\024\027\036\027\021\024\r: \023\035\024\021\027\024 \031\023\ \026\022\024\r\026\027\027\t\b \r\036\030\036\021\036\027\024\r\017\007\027\ \t\b )Tj 0.129 Tw 0 -1.218 TD (\001\r\026\027\027\024\r\f\022\017\b \022\035\036\021\024\022 \(\021\017\ \023\026 \202\027\021\024\027\017 \202\) \017)Tj /Span<>> BDC ( )Tj EMC (\030\t\b\035\t\b \024\027, )Tj 0.201 Tw T* (\002\024\020\026\021\t\b \020\017\f\021\017\024\006\017\021\026\n\017 \(\ \021\017\023 \202\027\021\024\027\017 \207\), \021\026\022\032\036 \n\024\ \020\031\021 )Tj 0.104 Tw T* (\235\024\030\n\017\030\024\r\026\021\034\f\016 \f\023\036\006\017\235\017\ \004\036\f\022\017\036 \f\021\030\031\022\021\031\030\t)Tj /Span<>> BDC ( )Tj EMC (\227 \021\036\035\034\006\026 )Tj 0 Tw T* (\200\036\030\024\022\026\017 [52].)Tj /T1_2 1 Tf 0.061 Tw T* [(\025\r\005\006\002\234\b\240\002\220\006\t\b\b\013\r )0.5(\002\212\210\216\002\f\t)]TJ /Span<>> BDC ( )Tj EMC /T1_1 1 Tf (\227 \020\036\021\036\030\024\020\036\027\027\026\016 \020\030\031\023)Tj 0 Tw (-)Tj -0.002 Tw 0 -1.218 TD (\023\026 \027\024\r\024\024\002\030\026\024\r\026\027\017\005, \r\f\021\ \030\036\004\026\033\013\026\016\f\016 \r\024 \r\f\036\b \024\030\020\026\ \027\026\b )Tj -0.024 Tw 0 -1.218 TD (\240\025\221, \023\030\024\017\f\b\024\007\016\013\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\005\030\024\220\027\007\024\022\030\017\027\027\t\b \022\035\036\ \021\024\022 \220\n)Tj 0 Tw (-)Tj 0 -1.218 TD (\002\030\017\024\027\026\035\034\027\024\005 \022\017\001\022\017 [45].)Tj 0.141 Tw T* (\215\030\017 \220\027\007\024\f\024\027\024\020\030\026\235\017\004\036\f\ \022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \203\233\210 \r\017\ \031)Tj 0 Tw (-)Tj 0.097 Tw T* (\026\035\017\017\030\031\033\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\027\017\006\036 \f\035\017\017\f\021\024\005 \024\002\024\035\ \024\004\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.106 Tw T* (\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \220\b\024\f\035\024\017\), \017\n\036\033\021 \020\024\n\024\020\036\027\ \027\031\033 )Tj 0.122 Tw T* (\f\021\030\031\022\021\031\030\031, \004\036\021\022\017\036 \020\035\026\ \007\022\017\036 \022\024\027\021\031\030\t, \f\030\036\007\027\036\023\024\ \027\017\032\036\027)Tj 0 Tw (-)Tj T* (\027\031\033 \220\b\024\020\036\027\027\024\f\021\034 \017\035\017 \017\ \024\220\b\024\020\036\027\027\024\f\021\034 [26].)Tj 0.168 Tw T* (\233\211\222 \017\020\030\026\036\021 \r\026\032\027\031\033 \030\024\035\ \034 \r)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\020\027\024\f\021\017\022\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 )Tj 0.534 Tw T* [(\027\026\035\017\004\017\016 )0.6(\023\024\030\026\032\036\027\017\016 )0.5(\030\036\020\017\024\027\026\030\027\t\b )0.5(\035\017\n\235\026\021\017\004\036\f\022\017\b )]TJ 0.025 Tw T* (\031\035\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\017\016 \020\017\f\021\024\035\024\020\017\004\ \036\f\022\024\020\024 \n\026\021\036\030\017\026\035\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj -0.007 Tw T* (\n\024\013\034\033 \233\211\222-\221\230\215. \212\017\026\020\027\024\f\ \021\017\004\036\f\022\026\016 \021\024\004\027\024\f\021\034 \233\211\222\ \026\r\017)Tj 0 Tw (-)Tj 0.069 Tw T* (\f\017\021 \024\021 \030\026\n\036\030\026 \027\024\r\024\024\002\030\026\ \024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \035\024\022\026\035\017\026\006\017\017, )Tj 0.297 Tw T* [(\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034 )0.6(\n\036\021\024\007\026 )0.5(\r\026\030\034\017\030\031\036\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.887 0 Td [(\023\030\036\007\036\035\026\b )0.6(\024\021 )]TJ 0.068 Tw -16.887 -1.218 Td (40 \007\024)Tj /Span<>> BDC ( )Tj EMC (90% [46]. \210\007\027\026\022\024 \023\024\f\022\024\035\034\022\031 \021\ \024\004\027\024\f\021\034 \035\031\004\036\r\t\b )Tj 0.163 Tw T* (\n\036\021\024\007\024\r \r\017\031\026\035\017\026\006\017\017, \021\026\ \022\017\b \022\026\022 \025\221, \204\217\221 \017)Tj /Span<>> BDC ( )Tj EMC (\215\233\221/\025\221 )Tj 0.085 Tw T* [(\021\026\022\032\036 )0.5(\024\020\030\026\027\017\004\036\027\026, )0.6(\233\211\222 )0.5(\024\f\021\026\036\021\f\016 )0.5(\023\030\017\024\030\017\021\036\021\027\t\n )0.6(\007\017\026\020)]TJ 0 Tw (-)Tj 0.365 Tw T* (\027\024\f\021\017\004\036\f\022\017\n \f\023\024\f\024\002\024\n \024\006\ \036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \203\233\210. )Tj 0.241 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\022\024\030\024\f\021\017 \ \023\030\024\035\017\235\036\030\026\006\017\017 \007\036\035\016\021\f\016\ )Tj 0.174 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.38 0 Td [(3 )0.5(\020\030\031\023\023\t: )0.5(G1, )0.6(G2 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.54 0 Td [(G3. )0.5(\212\035\016 \r\t\016\r\035\036\027\017\016 )0.6(\035\024\022\026\004\036)]TJ 0 Tw (-)Tj 0.209 Tw -9.921 -1.218 Td (\f\021\r\036\027\027\024\020\024 \023\024\021\036\027\006\017\026\035\026\ \024\023\030\036\007\036\035\016\036\021\f\016 \004\017\f\035\024 \n\017\ \021\024\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\036\022\f Ki-67.)Tj /T1_2 1 Tf 0.542 Tw T* (\026\002\217\212\004\f\t\003\r\f\001\b\013\005 \226\t\206\006\002\213\b\013\ \005 \212\002\f\t\212 \(\026\203\200\))Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (\227 )Tj 0.601 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\036, \f\024\f\021\024\016\ \013\036\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\036\021\036\027\024\r\017\007\027\t\b )Tj 0.192 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\026\035\017\021\036\035\034\027\t\b \022\035\036\021\024\022\ , \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\036\035\022\017\b \f\024\f\031\007\024\r. )Tj 0.497 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\n \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.054 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \023\024\ \035\017\023\024\r\017\007\027\024\036 \027\024\r\024\024\002\030\026\024\ \r\026\027\017\036 )Tj 0.352 Tw T* [(\023\035\024\021\027\024\220\035\026\f\021\017\004\036\f\022\024\005 )0.6(\022\024\027\f\017\f\021\036\027\006\017\017. )0.6(\210\f\027\024\r\027\t\036 )0.6(\233\211\222-)]TJ 0 Tw T* (\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \200\205\215:)Tj -0.006 Tw T* (\251)Tj /Span<>> BDC [( )-273( )]TJ EMC 1 0 Td [(\020\017\023\024\220\b\024\020\036\027\027\024\036 )0.6(\024\002\030\026\024\r\026\027\017\036 )0.6(\024\007\027\024\030\024\007\027\024\005 )0.5(\220\b\024\f\021\030\031\022)]TJ 0 Tw (-)Tj T* (\021\031\030\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\201\021\022\017\n\017 \022\024\027\021\031\030\026\n\017;)Tj 0.211 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-56( )]TJ EMC 1 0 Td (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.062 Tw T* (\035\024\004\022\017 \(2 \220\b\024\f\035\024\005\) \017\035\017 \023\024\ \007\f\035\017\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024)Tj /Span<>> BDC (-)Tj EMC 0 Tw T* (\f\035\024\005\) [26, 47].)Tj -0.022 Tw -1 -1.218 Td (\203\024\r\024\024\002\030\026\024\r\026\027\017\036 \f\024\f\021\024\017\ \021 \017)Tj /Span<>> BDC ( )Tj EMC 12.145 0 Td [(\r\036\030\036\021\036\027\024\r\017\007\027\t\b )0.5(\022\035\036\021\024\022, )]TJ -0.009 Tw -12.145 -1.218 Td [(\n\036\035\022\017\b )0.5(\f\024\f\031\007\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.412 0 Td [(\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.5(\022\035\036\021\024\022 )0.5(\(\220\024\017\027\024\235\017)]TJ 0 Tw (-)Tj -7.412 -1.218 Td (\035\t, \035\017\n\235\024\006\017\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\n\026\021\017\004\036\f\022\017\036 \022\035\036\021\022\017\ \) [27].)Tj /T1_2 1 Tf 0.034 Tw T* [(\032\206\r\006\006\004\b\003\b\004\235 )0.6(\212\002\240\202\r\f\210\240\002\201\b\004\235 )0.6(\202\r\f\r\213\004 )0.5(\(\032\200\207\))]TJ /T1_1 1 Tf /Span<>> BDC ( )Tj EMC [(\227 )0.5(\020\036)]TJ 0 Tw (-)Tj -0.051 Tw T* (\021\036\030\024\021\024\023\017\016 \023\026\027\022\030\036\026\021\017\ \004\036\f\022\024\005 \021\022\026\027\017 \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\t \024\030\021\024\021\024)Tj 0 Tw (-)Tj -0.015 Tw T* (\023\017\004\036\f\022\024\005 \023\024\007\032\036\035\031\007\024\004\027\ \024\005 \032\036\035\036\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \030\026\024\002\013\036)Tj 0 Tw (-)Tj 0.116 Tw T* (\027\017\036\n \017\b \022\030\024\r\024\f\027\026\002\032\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\027\036\030\r\026\006\017\017 \(\f\017\027\024\027\017\n\t: )Tj 0.002 Tw T* (\007\024\002\026\r\024\004\027\026\016 \023\024\007\032\036\035\031\007\024\ \004\027\026\016 \032\036\035\036\026, \b\024\030\017\f\021\024\n\026\)\ [48]. )Tj 0.497 Tw 23.244 64.543 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\n \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\n \017\f\f\035\036\007\024\r\026\027\017\017 )Tj 0.294 Tw T* [(\023\030\036\007\f\021\026\r\035\016\036\021 )0.5(\f\024\002\024\005 \023\024\035\031\f\235\036\030\017\004\036\f\022\024\036\ \017\035\017 )0.5(\022\024\027\031\f\024)]TJ 0 Tw (-)Tj -0.008 Tw T* (\r\017\007\027\024\036 \027\024\r\024\024\002\030\026\024\r\026\027\017\ \036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\021\016\032\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\026\035\034\027\024\005 )Tj 0.381 Tw T* (\004\026\f\021\017, \022\024\021\024\030\024\036 \f\024\024\021\r\036\021\ \f\021\r\031\036\021 \r\t\r\024\007\027\024\n\031 \023\030\024\021\024\022\ \031. )Tj 0 Tw T* (\210\f\027\024\r\027\t\036 \233\211\222-\b\026\030\026\022\021\036\030\017\ \f\021\017\022\017 \202\215\240 [49]:)Tj -0.032 Tw T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\020\036\021\036\030\024\020\036\027\027\024\036 \024\002\030\026\024\r\ \026\027\017\036 \020\017\023\024\220\b\024\020\036\027\027\024\005 \017\ \035\017 \017\024)Tj 0 Tw (-)Tj 0.354 Tw -1 -1.218 Td (\220\b\024\020\036\027\027\024\005 \f\021\030\031\022\021\031\030\t \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\017\n\017 \020\017\023\036\030\220\b\024\020\036\027\027\t\ \n\017 )Tj 0 Tw T* (\r\022\035\033\004\036\027\017\016\n\017 \(\023\024 \021\017\023\031 \253\ \f\024\035\034\226\023\036\030\036\006\273\);)Tj 0.428 Tw T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\024\023\030\036\007\036\035\016\036\021\f\016 \023\030\024\021\024\022\024\ \r\026\016 \f\021\030\031\022\021\031\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\201\021\022\017)Tj 0 Tw (-)Tj 0.462 Tw -1 -1.218 Td [(\n\017 )0.5(\022\024\027\021\031\030\026\n\017. )0.6(\210\002\030\026\024\r\026\027\017\036 )0.6(\017\f\b\024\007\017\021 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.832 0 Td (\023\024\007\f\035\017)Tj 0 Tw (-)Tj 0.229 Tw -18.832 -1.218 Td (\017\f\021\024\020\024 \f\035\024\016 \(3 \220\b\024\f\035\024\005\) \017\ \035\017 \n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 )Tj 0 Tw T* (\(4)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005\).)Tj 0.453 Tw 0 -1.218 TD (\203\036\017\027\r\026\017\r\027\t\036 \017\f\f\035\036\007\024\r\026\027\ \017\016 \r\017\031\026\035\017\026\006\017\017, \021\026\022\017\036 \ )Tj 0.098 Tw 0 -1.218 TD (\022\026\022 \025\221 \017)Tj /Span<>> BDC ( )Tj EMC (\204\217\221, \n\024\020\031\021 \023\024\022\026\026\021\034 \027\036\f\ \023\036\006\017\235\017\004\036\f\022\024\036 \031\f\017)Tj 0 Tw (-)Tj 0.24 Tw 0 -1.218 TD (\035\017\r\026\033\013\036\036\f\016 \031\021\024\035\013\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \017\035\017 \022\017\001\036\004\027\017\022\ \036, )Tj 0.258 Tw T* (\027\024 \027\036 \023\024\r\024\035\016\033\021 \024\022\024\027\004\026\ \021\036\035\034\027\024 \007\017\235\235\036\030\036\027\006\017\030\024\ \r\026\021\034 )Tj 0.087 Tw T* (\024\002\030\026\024\r\026\027\017\036, \233\211\222 \023\024\r\024\035\ \016\036\021 \024\023\030\036\007\036\035\017\021\034 \023\030\024\021\024\ \022\024\r\031\033 )Tj 0.287 Tw T* (\f\017\f\021\036\n\031)Tj /Span<>> BDC ( )Tj EMC (\227 \f\023\036\006\017\235\017\004\027\t\005 \023\030\017\027\026\022.\ \210\022\024\027\004\026\021\036\035\034\027\t\005 )Tj 0.04 Tw T* (\007\017\026\020\027\024 \r\036\030\017\235\017\006\017\030\031\036\021\ \f\016 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \020\017\f\021\024\035\024)Tj 0 Tw (-)Tj -0.012 Tw T* (\020\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016, \007\035\016 \023\024\035\031\004\036\027\017\016 \002\017\024\023\ \f\017\005\027\024\020\024 )Tj 0 Tw T* (\n\026\021\036\030\017\026\035\026 \r\024\n\024\032\027\024 \023\030\017\ \n\036\027\036\027\017\036 \233\211\222-\221\230\215 [50].)Tj /T1_2 1 Tf 0.601 Tw T* (\033\r\006\b\t\217\003\002-\220\f\r\003\002\201\b\004\235 \002\212\210\216\ \002\f\001 \(\033\021\017\), \t\f\t \002\212\210)Tj 0 Tw (-)Tj 0.236 Tw T* (\216\002\f\001 \032\206\006\t\220\002\217\002\004)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (\227 \024\021\027\024\f\017\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\n\031\030\026\035\034\027\t\n )Tj 0.432 Tw T* (\(\n\036\036\027\b\017\n\026\035\034\027\t\n\) \027\024\r\024\024\002\030\ \026\024\r\026\027\017\016\n \017)Tj /Span<>> BDC ( )Tj EMC (\022 \020\030\031\023\023\036 )Tj 0.422 Tw T* [(\030\036\007\022\017\b )0.5(\024\023\031\b\024\035\036\005 )0.6(\027\036\016\f\027\024\020\024 )0.5(\017\035\017 )0.6(\f\023\024\030\027\024\020\024 )0.5(\020\036\027\036\026. )]TJ 0.243 Tw T* (\215\030\036\007\f\021\026\r\035\016\036\021 \f\024\002\024\005 \027\036\ \002\024\035\034\001\024\036 \031\035\024\r\024\036 \027\024\r\024\024\002\ \030\026)Tj 0 Tw (-)Tj -0.011 Tw T* (\024\r\026\027\017\036 \002\035\036\007\027\024-\032\036\035\021\024\020\ \024 \006\r\036\021\026, \023\024\022\030\t\021\024\036 \027\036\017\n\036\ \027\036\027)Tj 0 Tw (-)Tj T* (\027\024\005 \f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\024\ \005. \233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \ [51]:)Tj 0.198 Tw T* (\251)Tj /Span<>> BDC [( )-69( )]TJ EMC 1 0 Td (\020\036\021\036\030\024\020\036\027\027\026\016 \020\017\023\024\220\b\024\ \020\036\027\027\026\016 \f\021\030\031\022\021\031\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 )Tj 0 Tw T* (\022\024\027\021\031\030\026\n\017;)Tj 0.786 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )519( )]TJ EMC 1 0 Td (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 )Tj 0.401 Tw T* (\024\002\024\035\024\004\022\017 \(2 \220\b\024\f\035\024\005\) \017\035\ \017 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016 )Tj 0 Tw T* (\(3)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005\).)Tj 0.063 Tw -1 -1.218 Td (\200\t\023\024\035\027\036\027\017\036 \233\211\222 \024\002\t\004\027\024\ \016\r\035\016\036\021\f\016 \f\035\036\007\031\033\013\017\n \001\026\020\ \024\n )Tj 0.045 Tw T* (\023\024\f\035\036 \r\t\023\024\035\027\036\027\017\016 \233\206\212\222\ , \007\035\016 \023\030\036\007\f\021\026\r\035\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024)Tj 0 Tw (-)Tj 0.226 Tw T* (\035\024\032\036\027\017\017 \024\002\030\026\024\r\026\027\017\016 \024\ \021\027\024\f\017\021\036\035\034\027\024 \f\035\024\036\r \024\030\020\ \026\027\024\r )Tj -0.018 Tw T* (\240\025\221, \021\026\022\032\036 \r\024\n\024\032\027\024 \r\t\023\024\ \035\027\036\027\017\036 \233\211\222-\221\230\215 \007\035\016 \023\024\ \035\031)Tj 0 Tw (-)Tj 0.037 Tw T* (\004\036\027\017\016 \002\017\024\023\f\017\005\027\024\020\024 \n\026\021\ \036\030\017\026\035\026 [51]. \216\026\030\026\022\021\036\030\027\026\016\ \n\017)Tj 0 Tw (-)Tj -0.039 Tw T* (\022\030\024\f\022\024\023\017\004\036\f\022\026\016 \022\026\030\021\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \003\025\210 \f\024\f\021\024\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\t\b )Tj 0.103 Tw T* (\020\027\036\007, \035\036\027\021 \017)Tj /Span<>> BDC ( )Tj EMC (\023\031\004\022\024\r \022\030\031\023\027\t\b \022\035\036\021\024\022\ \n\027\024\020\024\031\020\024\035\034\027\024\005 )Tj 0.354 Tw T* (\235\024\030\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\024\016\004\036\017\f\021\024\005 \026\006\017\007\024\235\ \017\035\034\027\024\005 \006\017\021\024\023\035\026)Tj 0 Tw (-)Tj 0.084 Tw T* (\n\024\005, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \r\f\021\030\036\004\026\033\021\f\016 \n\027\ \024\020\024\004\017\f\035\036\027\027\t\036 \026\006\017\007\024)Tj 0 Tw (-)Tj -0.008 Tw T* [(\235\017\035\034\027\t\036 )0.6(\036\030\027\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.254 0 Td [(\020\035\t\002\022\017 )0.5([52]. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.276 0 Td [(\230\206\216 )0.5(\017\f\f\035\036\007\024\r\026\027\017\017 )]TJ -0.007 Tw -14.531 -1.218 Td [(\n\026\030\022\036\030\026\n\017 )0.5(\024\023\031\b\024\035\017 )0.6(\202\002\030\017\022\024\f\024\r\026 )0.5(\016\r\035\016\033\021\f\016 )0.6(\n\026\030\022\036\030 )0.5(\r\017)]TJ 0 Tw (-)Tj 0.116 Tw T* (\n\036\027\021\017\027, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \002\036\035\022\017 S100, CD68, NSE, CD56 \017)Tj /Span<>> BDC ( )Tj EMC (EMA, )Tj 0.017 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\035\016 \024\023\030\036\007\036\035\036\027\017\ \016 \035\024\022\026\004\036\f\021\r\036\027\027\024\020\024 \023\024\021\ \036\027\006\017)Tj 0 Tw (-)Tj T* (\026\035\026 \024\023\030\036\007\036\035\016\036\021\f\016 \004\017\f\035\ \024 \n\017\021\024\024\r, \017\027\007\036\022\f Ki-67 [53].)Tj /T1_2 1 Tf 0.002 Tc 0.799 Tw T* [(\031\210\212\f\t\220\004\204\t\002\b\b\013\r )0.5(\220\t\217\003\013. )]TJ /T1_1 1 Tf 12.624 0 Td [(\212\031\023\035\017\022\026\006\017\024\027\027\t\036 )0.5(\022\017)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.302 Tw -12.624 -1.218 Td (\f\021\t \240\025\221 \004\026\013\036 \r\f\036\020\024 \r\f\021\030\036\ \004\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\r\007\024\001\027\024\005)2( )]TJ 0.326 Tw T* (\022\017\001\022\036, \023\017\013\036\r\024\007\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\036 [54]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.326 Tw T* (\007\024\f\022\024\023\017\004\036\f\022\024\n \024\f\n\024\021\030\036 \ \024\002\t\004\027\024 \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.345 Tw T* (\002\024\005 \007\036\235\024\030\n\026\006\017\033 \f\021\036\027\022\017\ \017\035\017 \021\024\027\022\024\f\021\036\027\027\024\036 \027\024\r\024\ )Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.201 Tw T* [(\024\002\030\026\024\r\026\027\017\036, )0.5(\f\035\017\017\f\021\026\016 )0.5(\027\026\007 )0.5(\022\024\021\024\030\t\n )0.6(\027\036 )0.5(\017\n\036\027\036\027\026.)2( )]TJ -0.002 Tw T* (\233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\017:)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_3 1 Tf 25 0 0 25 505.5021 56.0378 Tm (175)Tj ET endstream endobj 100 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.158 Tw 10 0 0 10 70.8661 396.0239 Tm (\027\026\017\002\024\035\036\036 \f\023\036\006\017\235\017\004\027\t\n.\ \221\026\022\032\036 \023\030\024\r\024\007\017\021\f\016 \n\024\035\036\ \022\031)Tj 0 Tw (-)Tj 0.239 Tw 0 -1.218 TD (\035\016\030\027\024-\020\036\027\036\021\017\004\036\f\022\024\036 \017\ \f\f\035\036\007\024\r\026\027\017\036 \n\031\021\026\006\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\036\027\026\b )Tj 0 Tw T* (KIT \017)Tj /Span<>> BDC ( )Tj EMC (PDGFR\202)Tj /Span<>> BDC ( )Tj EMC ([36].)Tj /T1_1 1 Tf T* (\035\r\005\002\214\t\002\214\004)Tj /T1_0 1 Tf 0.326 Tw ( \016\r\035\016\036\021\f\016 \017\f\021\017\027\027\t\n \n\t\001\036\004\ \027\t\n \017\027\021\030\026)Tj 0 Tw (-)Tj 1.154 Tw T* (\n\031\030\026\035\034\027\t\n \027\024\r\024\024\002\030\026\024\r\026\ \027\017\036\n, \030\026\r\017\r\026\033\013\017\n\f\016 )Tj 0.309 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\026\007\022\024\n\t\001\036\004\027\t\b \022\035\036\021\024\022\ , \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, \035\024)Tj 0 Tw (-)Tj 0.312 Tw T* (\022\026\035\017\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\017\013\036\r\024\007\036. \003\035\024\022\026\004\036\f\021\r\036\ \027\027\t\005 )0.5(\r\026\030\017\026\027\021 )]TJ 0.03 Tw T* (\035\036\005\024\n\017\024\n\t)Tj /Span<>> BDC ( )Tj EMC (\227 \035\036\005\024\n\017\024\f\026\030\022\024\n\026, \027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\240\025\221 \024\027\026 \r\f\021\030\036)Tj 0 Tw (-)Tj 0.218 Tw T* (\004\026\036\021\f\016 \004\030\036\r\t\004\026\005\027\024 \030\036\007\ \022\024 \017,)Tj /Span<>> BDC ( )Tj EMC (\022\026\022 \023\030\026\r\017\035\024, \007\017\235\235\036)Tj 0 Tw (-)Tj 0.233 Tw T* (\030\036\027\006\017\026\035\034\027\026\016 \007\017\026\020\027\024\f\021\ \017\022\026 \023\030\024\r\024\007\017\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210 [38]. )Tj 0 Tw T* (\210\f\027\024\r\027\t\036 \233\211\222-\b\026\030\026\022\021\036\030\017\ \f\021\017\022\017 \035\036\005\024\n\017\024\n\t:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\004\036\021\022\017\036 \022\024\027\021\031\030\t;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\020\024\n\024\020\036\027\027\026\016 \020\017\023\024\220\b\024\020\036\ \027\027\026\016 \f\021\030\031\022\021\031\030\026;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\n\024\032\036\021 \002\t\021\034 \n\027\024\020\024\022\026\n\036\030\027\ \024\005.)Tj -0.035 Tw -1 -1.218 Td (\210\002\030\026\024\r\026\027\017\036 \017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 \(4)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f)Tj 0 Tw (-)Tj 0.29 Tw T* (\035\024\005\) \017\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.302 Tw T* (\035\024\004\022\017 \(2)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005\). \203\036\030\024\r\027\t\036 \022\030\026\016\ , \027\036\024\007\027\024\030\024\007\027\026\016 )Tj 0.087 Tw T* [(\220\b\024\020\036\027\027\024\f\021\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\220\b\024\020\036\027\027\t\n\017 )0.5(\r\022\035\033\004\036\027\017\016\n\017, \031\r\036\035\017\004\036)]TJ 0 Tw (-)Tj 0.094 Tw T* (\027\017\036 \030\036\020\017\024\027\026\035\034\027\t\b \035\017\n\235\ \026\021\017\004\036\f\022\017\b \031\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\017 \233\211\222-)Tj -0.045 Tw T* (\023\030\017\027\026\022\017 \n\024\020\031\021 \031\022\026\t\r\026\021\ \034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\004\036\f\021\r\036\027\027\t\005 \b\026\030\026\022)Tj 0 Tw (-)Tj T* (\021\036\030 \027\024\r\024\024\002\030\026\024\r\026\027\017\016.)Tj 0.092 Tw T* (\212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \021\024\004\027\ \024\f\021\034 \233\211\222 \n\024\032\036\021 \007\024\f\021\017\020\026\ \021\034 \024\022\024)Tj 0 Tw (-)Tj 0.079 Tw T* (\035\024 86\22688% [45]. \210\007\027\026\022\024 \027\036 \f\031\013\036\ \f\021\r\031\036\021 \f\023\036\006\017\235\017\004\036\f)Tj 0 Tw (-)Tj 0.454 Tw T* (\022\017\b \233\211\222-\022\030\017\021\036\030\017\036\r \007\035\016 \ \007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 \007\017\ \026\020)Tj 0 Tw (-)Tj 0.186 Tw T* (\027\024\f\021\017\022\017 \017\027\021\030\026\n\031\030\026\035\034\027\ \t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \024\030\020\026\ \027\024\r )Tj 0.163 Tw T* (\r\036\030\b\027\017\b \024\021\007\036\035\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ , \021\024\004)Tj 0 Tw (-)Tj 0.262 Tw T* [(\027\024\f\021\034 )0.5(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\023\024\r\t\001\026\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 15.918 0 Td [(\f\024\004\036\021\026\027\017\017 )0.6(\233\211\222 )]TJ -0.047 Tw 7.326 31.663 Td (\f)Tj /Span<>> BDC ( )Tj EMC [(\021\024\027\022\024\017\020\024\035\034\027\024\005 )0.5(\023\031\027\022\006\017\036\005 )0.5(\(\221\230\215\) \f)]TJ /Span<>> BDC ( )Tj EMC 14.343 0 Td [(\023\024\f\035\036\007\031\033\013\036\005 )0.5(\n\024\030)]TJ 0 Tw (-)Tj 0.17 Tw -14.343 -1.218 Td (\235\024\035\024\020\017\004\036\f\022\024\005 \r\036\030\017\235\017\022\ \026\006\017\036\005)Tj /Span<>> BDC ( )Tj EMC ([39]. \206\017\f\021\024\035\024\020\017\004\036\f\022\026\016 )Tj 0.107 Tw T* [(\r\036\030\017\235\017\022\026\006\017\016 )0.6(\035\036\005\024\n\017\024\n )0.5(\027\036 )0.5(\r\t\t\r\026\036\021 )0.5(\021\030\031\007\027\024\f\021\036\005, )0.6(\027\024 )]TJ 0.25 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \r\f\036\020\007\026 \023\030\024\r\024\007\ \016\021 \230\206\216-)Tj 0.354 Tw T* (\235\036\027\024\021\017\023\017\030\024\r\026\027\017\036 \007\035\016 \ \017\f\022\035\033\004\036\027\017\016 \206\230\222\210. \210\023\031\b\024\ \035\017 )Tj -0.05 Tw T* (\016\030\022\024 \220\022\f\023\030\036\f\f\017\030\031\033\021 \007\036\ \f\n\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\020\035\026\007\022\024\n\t\001\036\004\027\t\005 \026\022\021\017\027 \ )Tj 0.447 Tw T* [(\(SM-\026\022\021\017\027\). )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 7.831 0 Td [(\035\024\022\026\004\036\f\021\r\036\027\027\024\005 )0.5(\021\030\026\027\f\235\024\030\n\026\006\017\017 )]TJ 0.271 Tw -7.831 -1.218 Td (\035\036\005\024\n\017\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\005\024\n\017\024\f\026\030\022\024\n\031)Tj /Span<>> BDC ( )Tj EMC (\227 \n\024\030\235\024\035\024\020\017\004\036\f\022\017 )Tj 0.226 Tw T* (\r\t\016\r\035\016\036\021\f\016 \r\t\f\024\022\017\005 \n\017\021\024\021\ \017\004\036\f\022\017\005 \017\027\007\036\022\f \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026)Tj 0 Tw (-)Tj T* (\032\036\027\027\t\005 \022\035\036\021\024\004\027\t\005 \023\024\035\017\ \n\024\030\235\017\n)Tj /Span<>> BDC ( )Tj EMC ([40].)Tj /T1_1 1 Tf T* (\016\004\b\b\002\214\004)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 0.132 Tw 4.923 0 Td (\227 \030\036\007\022\026\016 \017\027\021\030\026\n\031\030\026\035\034\ \027\026\016 \024\023\031\b\024\035\034 \027\036\005)Tj 0 Tw (-)Tj -0.04 Tw -4.923 -1.218 Td (\030\024\020\036\027\027\024\020\024 \023\030\024\017\f\b\024\032\007\036\ \027\017\016, \030\026\r\017\r\026\033\013\026\016\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\n\n\024)Tj 0 Tw (-)Tj 0.056 Tw T* (\006\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \022\035\036\021\024\022, \024\002\030\026\031\033\013\017\b \f\024\ \002\f\021\r\036\027\027\031\033 \024\002\024\035\024\004\022\031 )Tj 0.175 Tw T* [(\026\022\f\024\027\026. )0.5(\203\026\017\002\024\035\036\036 )0.6(\004\026\f\021\024 )0.5(\007\026\027\027\t\005 )0.5(\021\017\023 )0.5(\027\024\r\024\024\002\030\026\024\r\026)]TJ 0 Tw (-)Tj 0.115 Tw T* (\027\017\005 \024\002\027\026\030\031\032\017\r\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036, \023\017\013\036\r\024\007\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\n )Tj 0 Tw T* (\f\030\036\007\024\f\021\036\027\017\017)Tj /Span<>> BDC ( )Tj EMC ([41].)Tj 0.503 Tw T* (\215\024 \233\211\222-\022\026\030\021\017\027\036 \001\r\026\027\027\024\ \n\026 \f\b\024\032\026 \f)Tj /Span<>> BDC ( )Tj EMC (\035\036\005\024\n\017\024\n\024\005 )Tj 0.429 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210)Tj /Span<>> BDC ( )Tj EMC (\227 \004\026\013\036 \r\f\036\020\024 \030\026\f\023\024\035\026\020\026\ \036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004)Tj 0 Tw (-)Tj 0.457 Tw T* (\027\024\n \(4 \220\b\024\f\035\024\005\) \017\035\017 \023\024\007\f\035\ \017\017\f\021\024\n \(3 \220\b\024\f\035\024\005\) )Tj 0.799 Tw T* [(\f\035\024\036. )0.5(\212\017\235\235\036\030\036\027\006\017\026\035\034\027\026\016 )0.5(\007\017\026\020\027\024\f\021\017\022\026 )0.5(\r\024\n\024\032)]TJ 0 Tw (-)Tj 0.374 Tw T* (\027\026 \021\024\035\034\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \020\017\f\021\024\035\024\020\017\004\036\ \f\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\230\206\216 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([42].)Tj 0.487 Tw T* (\212\035\016 \023\024\035\031\004\036\027\017\016 \020\017\f\021\024\035\ \024\020\017\004\036\f\022\024\020\024 \n\026\021\036\030\017\026\035\026\ \r\024)Tj 0 Tw (-)Tj 0.269 Tw T* (\n\024\032\027\024 \r\t\023\024\035\027\036\027\017\036 \233\211\222-\221\ \230\215, \007\017\026\020\027\024\f\021\017\004\036\f\022\026\016 \021\024\ \004)Tj 0 Tw (-)Tj 0.211 Tw T* [(\027\024\f\021\034 )0.6(\022\024\021\024\030\024\020\024 )0.5(\f\024\f\021\026\r\035\016\036\021 )0.6(\024\021 )0.5(50 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 16.002 0 Td [(85,2% )0.5([43,44]. )]TJ 0.013 Tw -16.002 -1.218 Td (\210\022\024\027\004\026\021\036\035\034\027\026\016 \n\024\030\235\024\035\ \024\020\017\004\036\f\022\026\016 \021\030\026\022\021\024\r\022\026 \007\ \017\026\020\027\024\026 )Tj 0.028 Tw T* (\r\024\n\024\032\027\026 \002\035\026\020\024\007\026\030\016 \023\030\024\ \r\036\007\036\027\017\033 \230\206\216 \017\f\f\035\036\007\024\r\026\027\ \017\016. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 70.8661 730.4829 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \220\022\203\203\027\032\027\025\006\022\020\f\017\025\020\t \030\022\020\ \b\025\031\024\023\022\n\020 \022\025\032\020\026\r\032\020\f\017\025\013\ \200 \025\031\021\031\031\240\032\020\016\031\021)0.5(\020\025\022\235 \031\032\b\020\025\031\021 \255\027\f\r\030\031\007\025\ \031-\n\022\213\027\007\025\031\b\031 \023\032\020\n\023\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)5.1(f)-42.3(f)-13.4(e)-6(r)-2(e)-7(n)-0.6(t)-29.1(i)1.5(a)-4.5(l d)-2.9(i)1.5(a)-5.2(g)-2.4(n)-2.4(o)-1.1(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(i)3.9(n)-0.6(t)-9.6(r)3.3(a)-5.1(m)1(u)1.6(r)3.3(a)-4.5(l n)-2.4(e)-10.4(o)-5.3(p)-4.9(l)-1.1(a)-7.1(s)5.1(m)3.2(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e g)-3.9(a)-7.2(s)-14.8(t)-9.6(r)-2(o)0.9(i)3.9(n)-0.6(t)-1.6(e)-22(s)-14.8(t)-29.1(i)4(na)-4.5(l t)-9.6(r)3.3(a)-9.2(c)-32.4(t)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.1809 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 153.3209 715.1809 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 212.8484 715.1809 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 715.1809 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 715.1809 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 436.7854 715.1809 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1117 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 153.3209 694.1117 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 212.8484 694.1117 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 246.8642 694.1117 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 694.1117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 436.7854 694.1117 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 673.3004 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 673.0504 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 153.3209 673.0504 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 673.0504 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 246.8642 673.0504 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 337.5728 673.0504 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 436.7854 673.0504 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 633.0391 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 632.7891 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 153.3209 632.7891 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 632.7891 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 246.8642 632.7891 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 337.5728 632.7891 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 436.7854 632.7891 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 592.7778 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 592.5278 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 153.3209 592.5278 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 592.5278 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 246.8642 592.5278 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 337.5728 592.5278 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 436.7854 592.5278 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 562.1166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 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cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 337.5728 531.2053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 436.7854 531.2053 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 500.794 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 500.544 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 153.3209 500.544 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 212.8484 500.544 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 246.8642 500.544 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 337.5728 500.544 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 436.7854 500.544 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 470.1327 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 469.8827 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 71.1161 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 153.3209 469.8827 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 153.3209 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 212.8484 469.8827 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 212.8484 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 246.8642 469.8827 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 246.8642 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 337.5728 469.8827 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 337.5728 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 436.7854 469.8827 cm 0 0 m 88.124 0 l S Q q 1 0 0 1 436.7854 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 429.8714 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 429.6214 cm 0 0 m 82.455 0 l S Q q 1 0 0 1 153.3209 429.6214 cm 0 0 m 59.528 0 l S Q q 1 0 0 1 212.8484 429.6214 cm 0 0 m 34.016 0 l S Q q 1 0 0 1 246.8642 429.6214 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 337.5728 429.6214 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 436.7854 429.6214 cm 0 0 m 88.124 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 90.8228 701.7463 Tm (\020\t\212 \002\212\210\216\002\f\t)Tj 9.453 0.6 Td (\017\206\002\f\002\201\220\004 )Tj 0.607 -1.2 Td (\217\003\r\b\220\t)Tj 6.395 1.2 Td (\231\216\002-)Tj -0.099 -1.2 Td (\217\f\002\005)Tj 5.763 0.6 Td (\231\216\002-\217\003\006\210\220\003\210\006\004)Tj 11.248 0.6 Td (\027\t\217\003\002\f\002\n\t\201\r\217\220\002\r)Tj 1.654 -1.2 Td (\255\003\006\002\r\b\t\r)Tj 9.661 0.6 Td (\034\027\225-\t\217\217\f\r\240\002\004\b\t\r)Tj /T1_0 1 Tf -46.791 -2.033 Td (\214\017\023\024\n\026)Tj 10.83 0 Td (\023\024\007\f\035\017\017\f\021\026\016 )Tj 8.408 0 Td (3)Tj 4.775 0 Td (\020\017\023\036\030\220\b\024\020\036\027\027\026\016)Tj 10.519 0 Td (\030\036\035\026\016 \002\036\035\026\016 \032\017\030\024\r\026\016 )Tj 3.493 -1.2 Td (\021\022\026\027\034)Tj 10.187 1.2 Td (\027\036 \021\030\036\002\031\036\021\f\016)Tj -48.213 -2.633 Td (\206\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\026\ \016 )Tj T* (\f\021\030\024\n\026\035\034\027\026\016 \024\023\031\b\024\035\034)Tj 11.522 1.2 Td (\n\t\001\036\004\027\026\016 )Tj 7.257 0 Td (2, 4 )Tj 3.325 0 Td (\020\017\023\024\220\b\024\020\036\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 )Tj 3.004 -1.2 Td (\022\024\027\021\031\030\026\n\017)Tj 8.538 1.2 Td (\r\036\030\036\021\036\027\024\r\017\007\027\024-\022\035\036\021\024\004\ \027\t\005 )Tj 4.808 -1.2 Td (\021\017\023)Tj -4.589 -1.2 Td (\220\023\017\021\036\035\017\024\017\007\027\024-\022\035\036\021\024\004\ \027\t\005 )Tj 4.589 -1.2 Td (\021\017\023)Tj 9.486 3.6 Td (\221\030\036\002\031\036\021\f\016 \007\035\016 )Tj -1.746 -1.2 Td (\r\t\016\r\035\036\027\017\016 \021\026\030\020\036\030\021\027\024\005 \ )Tj -0.228 -1.2 Td (\n\031\021\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016 )Tj 1.486 -1.2 Td (\020\030\031\023\023\026 \023\030\024\020\027\024\026)Tj -47.452 -1.433 Td (\214\036\005\024\n\017\024\n\026)Tj 10.65 0 Td (\n\t\001\036\004\027\026\016 \017\035\017 )Tj 0.872 -1.2 Td (\n\t\001\036\004\027\026\016 )Tj 0.016 -1.2 Td (\023\035\026\f\021\017\027\022\026 )Tj -0 -1.2 Td (\f\035\017\017\f\021\024\005 )Tj 7.242 3.6 Td (4, 2)Tj 6.137 0 Td (\020\024\n\024\020\036\027\027\026\016)Tj 10.254 0 Td (\r\036\030\036\021\036\027\024\022\035\036\021\024\004\027\026\016 )Tj -1.029 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\r\024\005 \f\021\030\024\n\024\005)Tj 15.184 1.2 Td (\017\027\024\020\007\026, )Tj -3.468 -1.2 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )Tj 0.936 -1.2 Td (\007\017\026\020\027\024\f\021\017\022\036 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210)Tj -46.793 -2.633 Td (\231\r\026\027\027\024\n\026)Tj 10.65 0 Td (\n\t\001\036\004\027\026\016 \017\035\017 )Tj 0.181 -1.2 Td (\023\024\007\f\035\017\017\f\021\026\016)Tj 7.949 1.2 Td (4, 3)Tj 15.806 0 Td (\r\036\030\036\021\036\027\024\022\035\036\021\024\004\027\026\016 \f\024\ )Tj -0.641 -1.2 Td (\f\021\030\031\022\021\031\030\026\n\017 \r\036\030\024\022\026\016 \017\ \035\017 )Tj -0.513 -1.2 Td (\001\r\026\027\027\024\r\f\022\017\n\017 \f\021\030\031\022\021\031\030\026\ \n\017)Tj 15.894 2.4 Td (\017\027\024\020\007\026, )Tj -3.468 -1.2 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )Tj 0.936 -1.2 Td (\007\017\026\020\027\024\f\021\017\022\036 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210)Tj -46.793 -1.433 Td (\203\036\005\030\024\220\027\007\024\022\030\017\027\027\026\016 )Tj T* (\024\023\031\b\024\035\034)Tj 10.706 1.2 Td (\f\035\017\017\f\021\026\016 \017\035\017 )Tj 0.124 -1.2 Td (\023\024\007\f\035\017\017\f\021\026\016)Tj 7.949 1.2 Td (2, 3)Tj 3.993 0 Td (\020\024\n\024\020\036\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\017\n\017 )Tj 2.336 -1.2 Td (\022\024\027\021\031\030\026\n\017)Tj 8.468 1.2 Td (\024\030\020\026\027\024\017\007\027\t\005 \021\017\023 \f\021\030\024\036\ \027\017\016 )Tj 14.405 0 Td (\021\030\036\002\031\036\021\f\016 \007\035\016 )Tj -0.885 -1.2 Td (\235\036\027\024\021\017\023\017\030\024\r\026\027\017\016 )Tj -0.836 -1.2 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016 \020\030\036\005\007\026 )Tj -46.26 -1.433 Td (\200\024\f\023\026\035\017\021\036\035\034\027\t\005 )Tj 0 -1.2 TD (\235\017\002\030\024\027\t\005 \023\024\035\017\023 )Tj 11.522 1.2 Td (\n\t\001\036\004\027\026\016 )Tj 0.016 -1.2 Td (\023\035\026\f\021\017\027\022\026 )Tj -0 -1.2 Td (\f\035\017\017\f\021\024\005 )Tj 7.701 2.4 Td (3)Tj 5.01 0 Td (\020\017\023\024\220\b\024\020\036\027\027\026\016 )Tj -1.773 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\036\021\022\017\n\017 \022\024\027\021\031\030\026\n\017)Tj 12.021 1.2 Td (\235\017\002\030\024\002\035\026\f\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\022\017 )Tj 2.248 -1.2 Td (\r\024\f\023\026\035\036\027\017\016 )Tj -36.745 -2.633 Td (\210\023\031\b\024\035\034 \202\002\030\017\022\024\f\024\r\026 )Tj 0 -1.2 TD (\(\036\030\027\017\f\021\024-\022\035\036\021\024\004\027\026\016\))Tj 11.522 1.2 Td (\n\t\001\036\004\027\026\016 )Tj 0.016 -1.2 Td (\023\035\026\f\021\017\027\022\026 )Tj -0 -1.2 Td (\f\035\017\017\f\021\024\005)Tj 7.701 2.4 Td (3)Tj 5.01 0 Td (\020\017\023\024\220\b\024\020\036\027\027\026\016 )Tj -1.773 -1.2 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\027\036\004\036\021\022\017\n\017 \022\024\027\021\031\030\026\n\017)Tj 12.609 1.2 Td (\036\030\027\017\f\021\024\022\035\036\021\024\004\027\t\005 )Tj 14.334 0 Td (\017\027\024\020\007\026)Tj -49.418 -3.833 Td (\202\002\036\030\030\026\027\021\027\026\016 )Tj T* (\023\024\007\032\036\035\031\007\024\004\027\026\016 )Tj T* (\032\036\035\036\026)Tj 22.302 2.4 Td (\020\036\021\036\030\024\020\036\027\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\035\022\017\n\017 )Tj 1.327 -1.2 Td (\020\017\023\036\030\220\b\024\020\036\027\027\t\n\017 )Tj -1.639 -1.2 Td (\r\022\035\033\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n )Tj 1.047 -1.2 Td (\023\030\024\021\024\022\024\r\024\005 \f\017\f\021\036\n\t)Tj 12.668 3.6 Td (\026\006\017\027\026\030\027\026\016 \021\022\026\027\034 )Tj -1.489 -1.2 Td (\023\024\007\032\036\035\031\007\024\004\027\024\005 \032\036\035\036\t\ )Tj 13.998 1.2 Td (\027\036 \021\030\036\002\031\036\021\f\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.9152 56.0378 Tm (174)Tj ET endstream endobj 101 0 obj <> endobj 98 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.021 Tw 10 0 0 10 42.5197 724.8299 Tm (\025\026\022 \023\030\026\r\017\035\024, \020\017\f\021\024\035\024\020\017\ \004\036\f\022\026\016 \r\036\030\017\235\017\022\026\006\017\016 \035\017\ \023\024\n \027\036 )Tj 0.184 Tw 0 -1.218 TD [(\r\t\t\r\026\036\021 )0.5(\021\030\031\007\027\024\f\021\036\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 10.319 0 Td [(\027\036 )0.5(\021\030\036\002\031\036\021 )0.6(\007\024\023\024\035\027\017\021\036\035\034\027\t\b )]TJ -0.045 Tw -10.319 -1.218 Td (\n\036\021\024\007\024\r \235\036\027\024\021\017\023\017\030\024\r\026\027\ \017\016, \021\026\022\017\b \022\026\022 \017\n\n\031\027\024\020\017\f\ \021\024\b\017)Tj 0 Tw (-)Tj -0.036 Tw T* (\n\017\004\036\f\022\017\005 \017\035\017 \n\024\035\036\022\031\035\016\ \030\027\t\005 \n\036\021\024\007\t. \221\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\017 )Tj /T1_2 1 Tf 0 Tw T* (\f\r\005\002\214\t\002\217\004\006\220\002\214\013 )Tj /T1_1 1 Tf 0.039 Tw 7.894 0 Td (\r\024\027\017\022\026\036\021 \027\036\024\002\b\024\007\017\n\024\f\021\ \034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031)Tj 0 Tw (-)Tj 0.123 Tw -7.894 -1.218 Td (\027\024\020\017\f\021\024\b\017\n\017\004\036\f\022\024\020\024 \(\230\206\ \216\) \235\036\027\024\021\017\023\017\030\024\r\026\027\017\017 \024\023\ \031\b\024)Tj 0 Tw (-)Tj 0.192 Tw 0 -1.218 TD [(\035\017. )0.5(\214\036\005\024\n\017\024\f\026\030\022\024\n\t )0.5(\004\030\036\r\t\004\026\005\027\024 )0.6(\030\036\007\022\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 19.554 0 Td (2000\226)Tj 0.11 Tw -19.554 -1.218 Td (2019)Tj /Span<>> BDC ( )Tj EMC (\020\020. \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\021\036\030\026\021\031\030\036 \024\023\017\f\t\r\026\036\021\f\ \016 \035\017\001\034 76)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036\r )Tj 0.086 Tw 0 -1.218 TD (\(\007\024 2000 \020\024\007\026 \n\027\024\020\017\036 \206\230\222\210\ \002\t\035\017 \027\036\023\030\026\r\017\035\034\027\024 \022\035\026\f\ )Tj 0 Tw (-)Tj 0.179 Tw T* (\f\017\235\017\006\017\030\024\r\026\027\t \022\026\022 \035\036\005\024\ \n\017\024\f\026\030\022\024\n\t\). \215\030\016\n\026\016 \022\017\001)Tj 0 Tw (-)Tj 0.416 Tw T* (\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 \036\007\017\027\f\021\r\036\027\027\t\005 \024\030\020\026\027 \032\ \036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024 )Tj 0.013 Tw T* (\021\030\026\022\021\026, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \035\036\005\024\n\017\024\f\026\030\022\024\n\ \026 \r\f\021\030\036\004\026\036\021\f\016 \004\026\013\036, )Tj 0.017 Tw 0 -1.218 TD (\004\036\n \206\230\222\210. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \n\024\030\235\024\035\ \024\020\017\004\036\f\022\031\033 \007\017\235)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\235\036\030\036\027\006\017\026\035\034\027\031\033 \007\017\026\020\027\ \024\f\021\017\022\031 \035\036\005\024\n\017\024\f\026\030\022\024\n \023\ \030\024\r\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\007\016\021 \f)Tj /Span<>> BDC ( )Tj EMC (\206\230\222\210, \027\024 \027\036 \f)Tj /Span<>> BDC ( )Tj EMC (\035\017\023\024\n\024\005.)Tj /T1_2 1 Tf 0.32 Tw 0 -2.436 TD (\027\004\217\003\006\002\t\b\003\r\217\003\t\b\004\f\001\b\013\r \217\003\ \006\002\214\004\f\001\b\013\r \002\212\210\216\002\f\t)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (\227 )Tj 0.651 Tw 0 -1.218 TD [(\027\026\017\002\024\035\036\036 )0.6(\004\026\f\021\024 )0.5(\r\f\021\030\036\004\026\033\013\017\036\f\016 )0.6(\017\027\021\030\026\n\031\030\026\035\034\027\t\036 )]TJ 0.246 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\016. \210\027\017, \023\ \030\036\017\n\031\013\036\f\021\r\036\027\027\024, \030\026\r\017\r\026\ )Tj 0 Tw (-)Tj 0.253 Tw T* (\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\017 \022\035\026\f\f\017\ \235\017\006\017\030\031)Tj 0 Tw (-)Tj 0.181 Tw T* [(\033\021\f\016 )0.5(\022\026\022 \r\036\030\036\021\036\027\024\022\035\036\021\024\004\027\t\ \005 )0.5(\021\017\023 )0.5(\(\007\024 70%\) [31,32]. )]TJ 0.081 Tw T* (\233\021\017 \024\023\031\b\024\035\017 \r\024\027\017\022\026\033\021 \ \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\f\021\017\006\017\026\035\034\027\t\b \022\035\036\021\ \024\022 )Tj 0.24 Tw T* (\025\026\b\026\035\016, \022\024\021\024\030\t\036 \016\r\035\016\033\021\ \f\016 \220\035\036\022\021\030\017\004\036\f\022\017\n\017 \r\024\007\017\ \021\036)Tj 0 Tw (-)Tj 0.031 Tw T* (\035\016\n\017 \030\017\021\n\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\021\024\030\026\n\017 \220\027\021\036\030\026\035\034\ \027\024\005 \027\036\005\030\024\021\030\026\027\f)Tj 0 Tw (-)Tj -0.037 Tw T* (\n\017\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\036 \240\025\221\ [33]. \210\002\030\026\024\r\026\027\017\036 )Tj 0.359 Tw T* (\017\f\b\024\007\017\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \024\002\024\035\024\004\022\017 \(4 \220\b\ \024\f\035\024\005\) \017\035\017 )Tj 0.336 Tw 23.244 30.445 Td (\030\036\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\024\005 \023\035\026\f\021\017\027\022\017 \f\035\017\ \017\f\021\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.382 Tw T* (\035\024\004\022\017 \(2 \220\b\024\f\035\024\005\). \210\f\027\024\r\027\ \t\036 \233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\017\ )Tj 0 Tw T* (\206\230\222\210)Tj /Span<>> BDC ( )Tj EMC ([34]:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\004\036\021\022\017\036 \022\024\027\021\031\030\t;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\024\007\027\024\030\024\007\027\026\016 \f\021\030\031\022\021\031\030\026\ ;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\020\017\023\024\220\b\024\020\036\027\027\024\f\021\034 \017\035\017 \023\ \024\027\017\032\036\027\027\026\016 \220\b\024\020\036\027\027\024\f\021\ \034;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\r\024\n\024\032\027\t \220\b\024\020\036\027\027\t\036 \r\022\035\033\004\ \036\027\017\016.)Tj -0.023 Tw -1 -1.218 Td (\025\030\024\n\036 \021\024\020\024, \027\036\022\024\021\024\030\t\036 \ \233\211\222-\023\030\017\027\026\022\017 \n\024\020\031\021 \031\022\026\ \t\r\026\021\034 )Tj 0.248 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\005 \030\017\f\022 \035\024\022\026\004\036\f\021\r\036\ \027\027\024\020\024 \023\036\030\036\030\024\032\007\036\027\017\016. )Tj 0 Tw T* (\025)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\n \023\030\017\027\026\022\026\n \024\021\027\024\f\016\ \021\f\016 [35]:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\027\036\030\024\r\027\t\036 \020\030\026\027\017\006\t;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\027\036\024\007\027\024\030\024\007\027\026\016 \220\b\024\020\036\027\027\ \024\f\021\034;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\026\027\220\b\024\020\036\027\027\t\036 \023\024\035\024\f\021\017;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC ( )Tj EMC 1 0 Td (\031\r\036\035\017\004\036\027\017\036 \030\036\020\017\024\027\026\035\034\ \027\t\b \035\017\n\235\026\021\017\004\036\f\022\017\b \031\035\024\r.\ )Tj 0.135 Tw -1 -1.218 Td (\212\035\016 \023\024\f\021\026\027\024\r\022\017 \024\022\024\027\004\026\ \021\036\035\034\027\024\020\024 \007\017\026\020\027\024\026 \021\030\036\ \002\031\036\021\f\016 )Tj 0.152 Tw T* (\r\t\023\024\035\027\036\027\017\036 \233\211\222-\221\230\215 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036\n \023\024\f\035\036\007\031\033\013\ \036\020\024 )Tj 0.321 Tw T* (\023\026\021\024\035\024\020\024\026\027\026\021\024\n\017\004\036\f\022\ \024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\230\206\216 \023\024\007)Tj 0 Tw (-)Tj 0.231 Tw T* (\021\r\036\030\032\007\036\027\017\036\n [36]. \221\024\004\027\024\f\021\ \034 \233\211\222-\221\230\215 \r\026\030\034\017\030\031\036\021 \024\021\ )Tj 0.04 Tw T* (50% \007\024)Tj /Span<>> BDC ( )Tj EMC (93% \017)Tj /Span<>> BDC ( )Tj EMC [(\026\r\017\f\017\021 \024\021 \021\026\022\017\b )0.5(\235\026\022\021\024\030\024\r \022\026\022 \030\026\n\036\030 )]TJ 0.068 Tw T* (\024\002\030\026\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\n\036\021\030\026 \017\020\035\t [37]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 )Tj 0.292 Tw T* (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016 \031\022\026\t\r\026\033\021 \020\017\f\021\ \024)Tj 0 Tw (-)Tj 0.638 Tw T* (\035\024\020\017\004\036\f\022\017\005 \023\024\007\021\017\023 \024\023\ \031\b\024\035\017 \(\r\036\030\036\021\036\027\024\022\035\036\021\024\004\ \027\t\036 )Tj 0.272 Tw T* (\206\230\222\210 \f\024\f\021\026\r\035\016\033\021 \024\022\024\035\024\ 70%, \220\023\017\021\036\035\017\024\017\007\027\024\022\035\036\021\024\ \004)Tj 0 Tw (-)Tj 0.112 Tw T* (\027\t\036 \206\230\222\210 \f\024\f\021\026\r\035\016\033\021 \024\022\024\ \035\024 20% \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\001\026\027\027\t\005 \023\024\007)Tj 0 Tw (-)Tj 0.009 Tw T* (\021\017\023)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\022\024\035\024 10%\), \022\024\035\017\004\036\f\021\r\024 \n\ \017\021\024\024\r, )0.5(\031\030\024\r\036\027\034 \220\022\f)]TJ 0 Tw (-)Tj 0.147 Tw T* (\023\030\036\f\f\017\017 CD117, DOG1, CD34, \023\030\017\004\036\n CD117\ \016\r\035\016\036\021\f\016 )Tj ET q /GS0 gs 453.543294 0 0 220.5324361 42.5196838 176.6469767 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.073 Tw 9 0 0 9 42.5197 165.7701 Tm (\022\t\217\210\b\002\220 10.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\025\030\031\203\031\023\031. \230\025\030\031\024\031\025\031\b\032\ \020\203\022\t. \220\022\203\203\027\032\027\025\006\022\020\f\017\025\013\ \027 \204\200\031\033\032\022\016\025\020\n\022 \022\025\023\032\020\026\ \r\032\020\f\017\025\013\200 \025\031\021\031\031\240\032\020\016\031\021\ \020\025\022\235: \003)Tj /Span<>> BDC ( )Tj EMC (\227 \b\020)Tj 0 Tw (-)Tj 0.013 Tw 0 -1.2 TD (\024\023\032\031\022\025\023\027\024\023\022\025\020\f\017\025\020\t \024\ \023\032\031\026\020\f\017\025\020\t \031\033\r\200\031\f\017 \255\027\f\ \r\030\n\020; \221)Tj /Span<>> BDC ( )Tj EMC (\227 \f\027\235\031\026\022\031\026\020 \255\027\f\r\030\n\020; \211)Tj /Span<>> BDC ( )Tj EMC (\227 \213\021\020\025\025\031\026\020 \255\027\f\r\030\n\020; \216)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027\235\032\031\204\025\030\031)Tj 0 Tw (-)Tj 0.048 Tw T* (\n\032\022\025\025\020\t \031\033\r\200\031\f\017 \255\027\f\r\030\n\020\ ; \220)Tj /Span<>> BDC ( )Tj EMC (\227 \021\031\024\033\020\f\022\023\027\f\017\025\013\235 \203\022\240\032\ \031\016\025\013\235 \033\031\f\022\033 \033\022\212\027\021\031\030\020\ ; \036)Tj /Span<>> BDC ( )Tj EMC (\227 \020\240\027\032\032\020\025\023\025\020\t \033\031\030\255\027\f\r\ \030\031\007\025\020\t \255\027\f\027\016\020 )Tj 0.058 Tw T* (\255\027\f\r\030\n\020; \234)Tj /Span<>> BDC ( )Tj EMC (\227 \016\027\032\025\022\024\023\031\n\f\027\023\031\007\025\020\t \031\ \033\r\200\031\f\017 \033\022\212\027\021\031\030\020; \207)Tj /Span<>> BDC ( )Tj EMC (\227 \030\r\033\f\022\n\020\006\022\031\025\025\020\t \n\022\024\023\020\ \(\204\025\030\031\203\031\023\031 \016\020\022\026\024\023\021\031\021\ \020\025\031 Wahi J.E., )Tj 0 Tw T* (Safdie F.M. [56]\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.093 Tw T* [(F)-16(igure 1)70(0.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endopho)13(to. Endosonog)14(raph)12(y)32(. Dif)-39.9(ferential echo signs of)]TJ /Span<>> BDC ( )Tj EMC [(intramural neoplas)33(ms: \003)]TJ /Span<>> BDC ( )Tj EMC [(\227 g)12(astrointestinal stromal tumor )]TJ -0.032 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the stomach; \221)Tj /Span<>> BDC ( )Tj EMC [(\227 g)12(astr)-37(ic leiom)11.1(yoma; \211)]TJ /Span<>> BDC ( )Tj EMC [(\227 g)11.9(astr)-36.9(ic schw)13(annoma; \216)]TJ /Span<>> BDC ( )Tj EMC [(\227 neuroendocr)-37(ine tumor of)]TJ /Span<>> BDC ( )Tj EMC (the stomach; \220)Tj /Span<>> BDC ( )Tj EMC [(\227 inf)-22(lammator)-43(y )]TJ 0.005 Tw T* [(f)-43(ibrous )0.6(polyp )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.387 0 Td [(the )0.5(esophagus; )0.5(\036)]TJ /Span<>> BDC ( )Tj EMC 6.864 0 Td [(\227 )0.5(aber)-16(rant )0.5(pancreas )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 9.564 0 Td [(the )0.5(stomach; )0.5(\234)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(g)14(ranular )0.5(cell )0.5(tumor )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 16.353 0 Td [(the )0.5(esophagus; \207)]TJ /Span<>> BDC ( )Tj EMC [(\227 )0.5(duplica)]TJ 0 Tw (-)Tj -39.169 -1.2 Td [(tion cyst \(endopho)13.1(to bor)-15.9(row)12(ed from W)30.1(ahi J.E., Safdie F)94.2(.M. [56]\))]TJ ET 1 0.68 0 0.12 k /GS0 gs 42.52 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 49.2345 292.3557 Tm (A)Tj ET 1 0.68 0 0.12 k 42.52 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 49.1795 182.5039 Tm (\031)Tj ET 1 0.68 0 0.12 k 155.055 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 161.7755 292.3557 Tm (\224)Tj ET 1 0.68 0 0.12 k 155.055 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 162.2429 182.5039 Tm (\036)Tj ET 1 0.68 0 0.12 k 273.26 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 279.9747 292.3557 Tm (\026)Tj ET 1 0.68 0 0.12 k 273.26 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 278.7592 182.5039 Tm (\207)Tj ET 1 0.68 0 0.12 k 386.15 286.422 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 393.4639 292.3557 Tm (\027)Tj ET 1 0.68 0 0.12 k 386.15 176.57 19.843 19.843 re f BT 0 0 0 0 k /T1_2 1 Tf 11 0 0 11 393.3099 182.5039 Tm (\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 505.5395 56.0378 Tm (173)Tj ET endstream endobj 99 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  {!1A"Qaq2S#3BRbr $%&'()*456789:CDEFGHIJTUVWXYZcdefghijstuvwxyzy!1AQaq"2B#$CR3br %&'()*456789:DEFGHIJSTUVWXYZcdefghijstuvwxyz?ǝ}sqX5sasc.!#~%z\9dN/f(cU:׫s^Hơ m.CY38>ẳgY-˄ֺub9jTwf3j=3: ,Su_ϣ Igϣ Anhxƫvs?8 *"pY2, ՟.2ωt@0ËGu͹jU$uB!ru_ϣ HџGgī.+L?LuʟuwTSMd:?F]e>gѿp%ä ;=;_5B ՟.3#F]g[0R 0h_T1~SӻʫrY}_ˣ HїF{ւYx>GvbwWHB~to?pW28Q/u%[ݘ?GuwTїG .3.shS_T1~Sӻʪ: ˣ HїGMhh`2+TyTxGfDKze0$}gˣ aK ON*;=;! ?F]a>ze0%JON*;=;ABїG .3.b5h%Ghoj1~}SӻʟuwU8;! nto?pW28khZ:)ެ_Tݘ>P@ }uYto??^t?Xh{ݻ=;_"%S ՟.1#?F]cV@8#9\8V+ʩIe ՟.2ωzl?>%ZƏ=;UxvT}b*2fj92$cƘqHct ՟.1.|^}a<&+u-$A+i!H楉DڏiMKUe=Y_p]U1>ຫcѿ0%gݘzUB~ຫcѿ0%A U_1~}S;ʪ'H_?F]aj/V~?ľ/y(gvbw׊ꞙUY)! ?F]gG/V~?Ļ@EսًꞙTwf/ϪzwyUHB/V~7ďNt|K OL|_T򪐈\?pW2, ՟.0ωw"OL|_TʪB !pugˣ aHїGgĻ_T1~}S;ʪB~:e0$zeѿ0%D+{=;_T򪐚/V~?ď^t?w"ON*;=;! ?F]cG/U?ĻS ON*;=;! ?F]cG/U?Ļ_g5ON*$ ՟0ϵA^.1.P{=;_B>:e;A~&=ݍ" zUM"їGgďNt|K4D{z*LU؆2nq 0| >$PII|}V?6]eϢ8xÝ7 J&MUa5܀crM\s= C= v&hBk F=cGU~z7ľjON*;=3f&%R<;2jU9Z#nU Wǣ aNNmFjDe}礗bl4j 5(V/ϪzgyQX>]pZ#q<0qf Sˈ5g =sД3 ȋquֿpQ2>zeѿ0x}aǑBv6t#ж_Q_ѻ $mMx;=3_Tv"蔗џF >3-bu2iiS_T~}S;ʠzҋ,SuGˣ aH8'|lZUՌꞙTwV/ϪzgyT=ޤv"Pảgѿp$Ả?(}?dp%' Juc2#cs8d=Y4/j 6Ÿ?mg˄t>/1,f{Z?C];ccqZJNV/ϪzgyUܑ=[Yp)JgFpz atsnLKt>a4n-k<#nX>@cjzgyQ=画$BG:D>_?'WSa6LWWs,+F،v:.߅GxR_T򣺱5OL*$3tP->3$zEĸExk[`KKg$Ik X>GucU!4.>o?GU~z7گouw׋ꞙUR~cѿ0p}U1jĭlsG0v*r^|c|tAoLꞨ%IZ I@347@ES/u>h"'aAݠH@ Z3TPI+fq19䣺dY"".B o-q,DˈFɂ% -j(~(tNegH"Ԝ6*!*wa\*"i3D'(SBHЪex lNI BKL1waaAMpM%-R$K ,p睢-~(x% " m(&Naddۜ'KTʌ)A;nZ <0M$AA@q&@}HABEIBcG.ѽCn! 4IU%+tbzsBB)nB!QI$!B0Nf!L&7BR!)֋7b5.V͋"GxDHBq$Yma;jrVX) ޾12]1k͚+W`~&&vd[˜lh& EĨGdô0'1:oM M<5Ln:DžI]6yB849l֋`!I!ru ,CYvGGbG$c^6SklS2=z1?;KqEJxX m.4.n~6l%@nn6'f{- 0" oek)t=Ru) ?jͦLH7zPh=|~_iؘ&=&z?K0l!YJQtJkwZA]\]m6FM  %"FO)$# Ns[ԁfqeT(*mkk 16l;CK|WwEdݓDLNDZ/ݪMr 5v"@BP.;NE$ H,UxcIlPR B]=] bm;&LI&(\ L5wR&!@IDj(J]\BԒy(!MRI6LQ"`(.$I B{{T8(B/.$hBZ*Y>P.TB%Q\;- ewt$\P6L0DH>&(5 \'ڥt@ױ| bu/v^a CCm0|-!a7kBRv vɾ׶溎Li.6O( F8Kdw tn5FΓ GH2bFaըSD G-RMz| 6s#"`N@*0zKW}-gv[7.$qRޱa۴bs#-*\G4(Š .;&АHq։JW;kD{Fcytr&ѐF/[vxia8;Cf "$[R$hhQ "Q-HuapcqX; aC ƣG@ZC{XQk5$dJe}PxXb;UR gtQ0c s0 mȄ!ZK!B!BCtF!sbǒb(EBUMЁTҠNSI0 S 9J[YdA0ޕ04! 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(bHIEX8'zT:3f>!o<SUdRmGZA:&@~ &ZrkG s ;,k^qtA't-1C#E"Ri.Sc*7+{\ Mn,<+bb>XƚE=}vk ?x}'k?O A}FWU$d& xߍlDbyb}=M8)!D$u u*kC4h:,ŔoKCq ADPBНgb3)Y 9BLε]^nn!NqTS`Isu^n\嚩YGB1!wmZ#n=B=ӿBpK`S.&"2$G|% XhJ=D:w#؊7hRnA>%VxP/$HQBx![Dn՝^Ή^}ح (_1D 9Q ^aLlu+ WBaݪj8*3t,Fdm`'$꾓:&> s1CJي)ql1^Q~cW mx)J+8XaLxe`/貹#z?Y7`I P8;TGPtz;z1%$]?zkK;ʅjm ˇ#0YS_Oza<th{1 lm+Ac,iNҞi {*+2n%fvY]藧F._g}aaުJE{VJr3tLju4'I'%$Bd,[L[ NWohԔ'0֊I ^[>?V}/ |cąM 5+%up>Rh4 >e:ըs#@_gۣF3EZ}t޷~wa4kLSy_;ߥu&;E frXU3qUa)8H벛k:MׁqApJ'" BqquܾY^ݧ  tL-o34 uZzēƁ< Uԕ/<ݡo3+"CnOR8},`QU5L0S_ mЅy× f:z+?o 50htAKmsismouMZ$0&NI8ýnΕÆǖ RZ6EhHparܹzK5..%#EԂѸ,!~]?fWIjJo&ɅP~=4^{Ert1лSje7 m|6-CZ{;lz. %{qq6o:WMvHMhv.kN}6Դ!vq>MbpNe*-k溓y EqPL-սUӺ]Ǥ^bᆖ⊉"f(B! !B!B!B!B!B!B!B!B!B!B!B!B!B!B!M) B\[/-֌),U φ6voe}_Jf w:^AMi,w,8ڼkX YSB\]Vpy r]I$!BhB!B!B!B!BIB!BBHB!4$!BHB!9BHB&IB&R! IRd͔Tg!\]c WOh~-4_Buz*9KlJkcTоOK' f]hY{W{1a%.V +`Xp9H4Sw2Bynոİ6r!„/Wb0($8 踇4 @u(ד u. &GZ굁8H)V_ e7drVr6\ wfjQ:f-`\K U6S\89 u8hgIi!yT/9(ii6R8_C<#V3aͱ^)aJ@}bAA#u<<\x ln+\ :GI`Ƕ3m}Y-ЂJ>AXvHp  g5= 86dXY|tfgp&$ h{@p R 뮎Z k+l?l.ӗI 4{A]Z8jfRtbH=bl8|`HM*]O̫ YauBˀZa}uY8^Z\a軇 7VMGL0ִ2lS\eN(BGH'}>}b@*C  {$[k"Y[su& lRW9x:DGA6)!su]TU8r9i Pqv!sC$o hhoBm \H^Gҏf+JOszvA.WL`~& ?wzH@ endstream endobj 284 0 obj <>stream endstream endobj 93 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.018 Tw 10 0 0 10 70.8661 724.8299 Tm (\f\021\036\027\022\017 \032\036\035\031\007\024\004\027\024-\022\017\001\ \036\004\027\024\020\024 \021\030\026\022\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (7\2269\) [26]. )Tj 0.299 Tw 0 -1.218 TD (\222)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \027\026\035\017\004\017\016 \023\026\021\024\020\ \027\024\n\024\027\017\004\027\t\b \023\030\017\027\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.094 Tw T* [(\220\021\017\b )0.5(\031\027\017\022\026\035\034\027\t\b )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022 )0.6(\035\017\023\024\n\t, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 18.138 0 Td (\002\024\035\034\001\017\027)Tj 0 Tw (-)Tj 0.162 Tw -18.138 -1.218 Td (\f\021\r\036 \f\035\031\004\026\036\r \023\024\021\030\036\002\027\024\f\ \021\034 \020\017\f\021\024\035\024\020\017\004\036\f\022\024\005 \r\036\ \030\017\235\017)Tj 0 Tw (-)Tj T* (\022\026\006\017\017 \024\021\f\031\021\f\021\r\031\036\021 [28].)Tj 0.922 Tw T* (\200\t\001\036\031\022\026\026\027\027\t\036 \220\027\007\024\f\024\027\ \024\020\030\026\235\017\004\036\f\022\017\036 \023\030\017\027\026\022\ \017 )Tj 0.007 Tw 0 -1.218 TD (100% \f\023\036\006\017\235\017\004\027\t \007\035\016 \035\017\023\024\n\ \t \(\036\007\017\027\f\021\r\036\027\027\024\036 \020\017\023\036\030)Tj /Span<>> BDC (-)Tj EMC 0.301 Tw 0 -1.218 TD (\220\b\024\020\036\027\027\024\036 \017\027\021\030\026\n\031\030\026\035\ \034\027\024\036 \024\002\030\026\024\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\034\036\n )Tj 0.196 Tw T* (\220\b\024\f\035\024\036\), \023\024\f\022\024\035\034\022\031 \035\017\023\ \024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\240\025\221 \023\030\026\022\021\017\004\036\f\022\017 \027\036 )Tj 0.248 Tw T* (\017\n\036\036\021 \030\017\f\022\026 \035\024\022\026\004\036\f\021\r\036\ \027\027\024\020\024 \023\036\030\036\030\024\032\007\036\027\017\016, \021\ \024\027)Tj 0 Tw (-)Tj 0.064 Tw T* [(\022\024\017\020\024\035\034\027\026\016 \023\031\027\022\006\017\016 )0.5(\023\024\007 \022\024\027\021\030\024\035\036\n \220\027\007\024\f\024\027\ \024\020\030\026\235\017\017 )]TJ 0 Tw T* (\(\233\211\222-\221\230\215\) \027\036 \021\030\036\002\031\036\021\f\016\ .)Tj 0.073 Tw 0 -1.218 TD (\222\024\020\035\026\f\027\024 \030\036\022\024\n\036\027\007\026\006\017\ \016\n, \233\211\222-\221\230\215 \023\024\022\026\026\027\026 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\017\027)Tj 0 Tw 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[(\024\r\026\027\017\036 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b )0.5(\n\036\021\024\007\024\r )0.6(\r\017\031\026\035\017\026\006\017\017, )]TJ 0.133 Tw T* (\220\027\007\024\f\024\027\024\020\030\026\235\017\017 \017, \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002\b\024\007\017\n\024\f\021\017, \n\024\030\235\024\035\024\ \020\017)Tj 0 Tw (-)Tj 0.288 Tw T* (\004\036\f\022\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016. \230\ \027\021\030\026\n\031\030\026\035\034\027\t\036 \027\024\r\024\024\002\030\ \026)Tj 0 Tw (-)Tj 0.06 Tw T* [(\024\r\026\027\017\016 \024\030\020\026\027\024\r \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 )0.5(\021\030\026\022\021\026 \n\024\020\031\021 )]TJ 0.135 Tw T* (\002\t\021\034 \027\036 \021\024\035\034\022\024 \007\024\002\030\024\022\ \026\004\036\f\021\r\036\027\027\t\n\017, \027\024 \021\026\022\032\036 \ \035\024)Tj 0 Tw (-)Tj 0.008 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\n\017 \017\035\017 \017\n\036\021\ \034 \035\024\022\026\004\036\f\021\r\036\027\027\t\005 \023\024\021\036\ \027\006\017)Tj 0 Tw (-)Tj 0.146 Tw T* [(\026\035. \233\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \031\035\ \034\021\030\026\f\024\027\024\020\030\026\235\017\016 )0.5(\(\233\211\222\) \f\031\013\036)]TJ 0 Tw (-)Tj 0.007 Tw T* [(\f\021\r\036\027\027\024 )0.5(\030\026\f\001\017\030\016\036\021 )0.5(\r\024\n\024\032\027\024\f\021\017 )0.5(\007\017\235\235\036\030\036\027\006\017\026\035\034\027\024\005 )]TJ 0.415 Tw T* [(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\017\027\021\030\026\n\031\030\026\035\034\027\t\b )0.6(\024\002\030\026\024\r\026\027\017\005 )0.5(\f\021\036\027\022\017 )]TJ 0 Tw T* (\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ \021\030\026\022\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (10\).)Tj 0.028 Tw T* (\204\027\024\020\017\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\017\b \n\024\032\027\024 \017\007\036\027\021\017\235\017\006\017\030\ \024\r\026\021\034 )0.5(\f\030\026\031 \023\024)]TJ /Span<>> BDC ( )Tj EMC (\017\b )Tj 0.08 Tw T* (\233\211\222-\b\026\030\026\022\021\036\030\017\f\021\017\022\026\n, \024\ \f\024\002\036\027\027\024 \035\017\023\024\n\t, \027\024 \007\035\016 \007\ \030\031)Tj 0 Tw (-)Tj 0.387 Tw T* [(\020\017\b \021\030\036\002\031\036\021\f\016 \020\017\f\021\024\035\024\ \020\017\004\036\f\022\026\016 )0.5(\r\036\030\017\235\017\022\026\006\017\016. \212\035\016 )]TJ -0.081 Tw T* (\022\026\032\007\024\020\024 \021\017\023\026 \024\002\030\026\024\r\026\ \027\017\016 \b\026\030\026\022\021\036\030\027\t \f\r\024\017 \f\023\036\ \006\017\235\017)Tj 0 Tw (-)Tj 0.012 Tw T* (\004\036\f\022\017\036 \233\211\222-\023\030\017\027\026\022\017, \004\021\ \024 \023\024\r\024\035\016\036\021 \024\021\035\017\004\026\021\034 \017\ \b \007\030\031\020 )Tj 0.109 Tw T* (\024\021 \007\030\031\020\026. \025\030\024\n\036 \021\024\020\024, \007\ \035\016 \022\026\032\007\024\020\024 \024\030\020\026\027\026 \b\026\030\ \026\022\021\036\030)Tj 0 Tw (-)Tj 0.12 Tw T* (\027\024 \023\030\036\024\002\035\026\007\026\027\017\036 \024\023\030\036\ \007\036\035\201\027\027\024\020\024 \r\017\007\026 \024\023\031\b\024\035\ \017. \221\026\022, )Tj 0.146 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\017\013\036\r\024\007\036 75% \r\f\036\b \027\024\r\024\024\002\030\ \026\024\r\026\027\017\005 \f\024\f\021\026\r\035\016\033\021 )Tj 0.008 Tw T* (\035\036\005\024\n\017\024\n\t, \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 60% \017\027\021\030\026\n\031\030\026\035\034\ \027\t\b \023\024\030\026\032\036)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\026\f\021\030\024\017\027\021\036\f\021\017\027\026\035\034\027\ \t\036 \f\021\030\024\n\026\035\034\027\t\036 \024\023\031\b\024\035\017\ )Tj 0.075 Tw T* (\(\206\230\222\210\), \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\036)Tj /Span<>> BDC ( )Tj EMC (\227 \035\036\005\024\n\017\024\n\t, )Tj 0.018 Tw T* (\206\230\222\210, \027\036\005\030\024\220\027\007\024\022\030\017\027\027\ \t\036 \024\023\031\b\024\035\017 \(\203\233\210\) \(20% \r \022\026\032\ )Tj 0 Tw (-)Tj -0.01 Tw T* (\007\024\n \f\035\031\004\026\036\) [30]. \222\r\024\036\r\030\036\n\036\ \027\027\026\016 \007\017\235\235\036\030\036\027\006\017\026\035\034\027\ \026\016 )Tj 0.077 Tw T* [(\007\017\026\020\027\024\f\021\017\022\026 \023\024\r\024\035\016\036\021\ )0.5(\024\023\030\036\007\036\035\017\021\034 \007\026\035\034\027\036\005\001\ \031\033 \021\026\022)]TJ 0 Tw (-)Tj T* (\021\017\022\031 \035\036\004\036\027\017\016 \023\026\006\017\036\027\021\ \026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj ET q 303.307 564.686 221.102 161.954 re W n q /GS0 gs 221.1023475 0 0 162.0457039 303.307086 564.5941099 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.4 Tw 9 0 0 9 303.3071 553.8859 Tm [(\022\t\217\210\b\002\220 )0.5(7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\230\025\030\031\024\031\025\031\b\032\020\203\022\t )0.5(\026\022\025\022\030\020\023\007\022\n\031\026 )]TJ 0 Tw 0 -1.2 TD (20)Tj /Span<>> BDC ( )Tj EMC (\215\216\006. \035\022\033\031\026\020 \025\022\255\025\027\b\032\r\030\025\ \031\b\031 \031\023\030\027\f\020 \033\022\212\027\021\031\030\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.189 Tw T* [(F)-16(igure 7)124(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. Endosonog)14.1(raph)12(y with a)]TJ /Span<>> BDC ( )Tj EMC (20 MHz mini)Tj 0 Tw (-)Tj T* [(p)46(robe. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC [(the low)12.2(er thoracic esophagus)]TJ ET q 303.307 349.028 221.102 161.954 re W n q /GS0 gs 221.1023475 0 0 162.0457039 303.3070555 348.9361812 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.4 Tw 9 0 0 9 303.3071 338.2279 Tm [(\022\t\217\210\b\002\220 )0.5(8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\230\025\030\031\024\031\025\031\b\032\020\203\022\t )0.5(\026\022\025\022\030\020\023\007\022\n\031\026 )]TJ 0 Tw T* (20)Tj /Span<>> BDC ( )Tj EMC (\215\216\006. \035\022\033\031\026\020 \020\025\023\032\020\f\017\025\031\ \b\031 \031\023\030\027\f\020 \255\027\f\r\030\n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.174 Tw T* [(F)-16(igure 8.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. Endosonog)14.1(raph)12(y with a)]TJ /Span<>> BDC ( )Tj EMC (20 MHz mini)Tj 0 Tw (-)Tj T* [(p)46(robe. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC (the antrum of)Tj /Span<>> BDC ( )Tj EMC (the stomach)Tj ET q 303.307 133.37 221.102 161.954 re W n q /GS0 gs 221.1023475 0 0 162.0457039 303.3070555 133.2782526 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.4 Tw 9 0 0 9 303.3071 122.57 Tm [(\022\t\217\210\b\002\220 )0.5(9.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\230\025\030\031\024\031\025\031\b\032\020\203\022\t )0.5(\026\022\025\022\030\020\023\007\022\n\031\026 )]TJ 0.156 Tw T* (20)Tj /Span<>> BDC ( )Tj EMC (\215\216\006. \035\022\033\031\026\020 \025\022\024\200\031\030\t\212\027\ \235 \007\020\024\023\022 \030\021\027\025\020\030\006\020\023\022\033\027\ \032\024\023\025\031\235 )Tj 0 Tw T* (\n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.178 Tw T* [(F)-16(igure 9)31.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13.1(to. Endosonog)14(raph)12.1(y with a)]TJ /Span<>> BDC ( )Tj EMC (20 MHz mini)Tj 0 Tw (-)Tj T* [(p)46(robe. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC (the descending duodenum)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8276 56.0378 Tm (172)Tj ET endstream endobj 95 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,R""  !1AQ"a2Bq# $%&'()*3456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyzi!1A"Q2aqBR3 #$%&'()*456789r:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz?|E3ҽڲ.Ζ|\v03XI"w<~dʜX\WE\o})O/ t~ljVp U{op-uSpH}*gvm]KV& RPVHjίu<_n/ WO:V_uQYoyZHRA)wr:W/vun ;y+ Vh(A;c ]D+n)Mq46;q6dM+#ѲIKc־&S OG#n XQI}R͚G9/ ei.FTň؇0asgd[W xq;k(VVNId5Z}vZؾx-M Za%IЗ. ֹSonp\(wzTƥ k@!8. m&x&ꐎ YQq6҂. :$8#ۻ&`$'m \ئHc~!cbsO:*H"vp⸅IᕩiYǔנ s+@O Î޵x?JP TXt !BE:(B()RME袊M:( JHRJE_EcUeLEw>QMKNdQW5:8To }KK4R(4V~R7r})#Or(4Vpu}Iҕ(:cʒ+U]న!e.'A+eBRKx GT9"EyxlvK- )DRBtAVYիß1L]Q> ̀Ľ$&(["EeyvH9PS~Q p0 $AH+ew֒T94z#hhiV+ 8yM|MHR5K$&dPifoyDQ[h$q|bF!*)`kg B5ja)A9(TVu]X8&%kؘTSLL-Ek"H J|*^!jEdEۄ`#r㳁=o"z+M%VԐ;oZ\!QB46ʑk}(FhtWkOyLH|[j$!:OMny'En7CT,,:ďZJdx5(oQRTdu RrRt8\+q#_ى /IyvWwmϿU{ י!AټOm )! $$-(=p\aI^z1ӧ:ݧ?vW֑|׻X)Wx8950B4`^Mz/!qC6{G56Mqk;F㸾/ÁqUGxr_5UJ_{^G{S]'Ok}RyuL BTyJ*")*t!EQE$Ejtz?#FaOnivp&NK!xâIzsZCn Ɗ0 :Iaml3K!`1@kۤUR4H\i{7n]ht,oV8"z +5v*GoU~ ]$b猌.U=v⸎))hU IGRBnL_.{}޸> kTȂH9OF0G#c( TJ1FgٗMu~W#vvۛQcE 5^O/*þ/]x$\5[RqlWqa$'evƹ~+ci}~8v>Ci`q/|w@EkLd6Ğ ozw)[xV a P+I#X4kz%#CJETy"X V u!A"5(iuI 64USi#ʗKN-!j^OVӶudJitA&% q.]l)Ԃ{*%ٳV-5 e e*  Zqm|799> ܓo!ko?+J5*؟^Ҩ? ῥQ__|QEѣp`9O/>zZZ+pGZN\5;l114}e403[xF1`2\ni,xrE  fݸpQL +5v~V8Unn@5d%0i5_pmUmWl_B>H/r7j]#Mp܇F A)T^ǿoq?8Jav]$oVc8o>WLPЀj/:fM^5Vyv;#iw/_UP䓍n:i*\ē._n۵hEXr{Ͻ*$QSdqQyŭ^ԞSxt2M^bvuŪq'W/{PAӧGmz촧>J}ݷۙjIRBԣI"kUgPw4vJB[R 0Τ=DPv=5F(k8XME]tTRwˀ0vrNd:8 W.!vnJM'p/uVj(U%>Th6G0F#(iZyt)EwSvx 4*@ jEq9ѐzES[B8 CR0Oz69Q*)H.4'Mŕh>⨻w6(.q e*K8em[9)B!jQZt qVD -JG\7H (Dvn(sB Qiq \JH'?CXR]%-\LjIct0ީ4AJEQ`nj(W ڮ*bBoPZRN*< *ߥ6HLkXe I̳e\cjK6n@VuyjsEĺT,:_ϥ\O'5&[ډ`H_THsESq7MBxUYQ$}Vb_ZRh#aWrTBR0E:)-w=7kOh'P?yDBttP(Crk4oVKׯ[o@$ՋWr#|u1|sCY)wKZmj JC(<ɁU+b]+HCs^G}wo6o*xէHԝJv2^svnJ[WЕIySy24ESt^P: Hu`>Ke 4xɯi6qAj8yKb" ꀴ|>{&֎ JCAI#jk8}o%E"xC#Q,Up]{7ܿxrt=~ Jn@v 󣵻3v.8;|'n:='Y $5qMk8O K([;1aԖ} CŅKD"O bk[tH@޾sᬄVsWq) tTUHFqD6˨sܯxd_+OWh *>DW\B{nB{aTJ-'IY',TADž=1S 8QGCܐc.kI @$uă u,CZ|Lb"֊kZh.#zz\nl^N(@ N$ҮXRWm[,l7MX  $,Hb(j9fz-c洐9 1[]o𓙇J#4QM+!nj9̑cHpLGI>+0ș $cd % FC }Y|g mbp!W$gh|w nt".8ڮ -9Iy+}WM=WqJ{! , {0$|!wnm%qkJ. /Jn$_ 5J}(QHb ](Z]gXb2Vҹh%Egyn\$zmXMn@r Ҳ]U¿z*i~7-bIܝ sNn&y@"I N-HEiBN0jjZ 0NMh"zYU\j9nvmVL?ХMR6@v#>J#p=T="i !XqA#C8roU˓ r0F7)I"(E:|@ I:֒`)gDjw@ jFG:(dEh! :O~My *(%ZԠ5_I;Ңwzo6_OĨDBH-ObSmJY" |jzHi 3EjN-z?L C3Y^W,_KwkB݅h@%M=7&pZČRNХH$zM$rd 9]Iթ.Mm5Sa:u$Dh*E 45dȦt3Q~cPwtyD} r-*]\R-^վ%i%@sH 9c\'RI}YER CNj΢(JF(6w% ҭ^ *;7_eaI \ Bd:dljv;iЋjIp}uLCʗ^I׍U7V $'ٚnХ4',~ZKJRiQ t+p 5tT#H.w\EX D[r FQLwHQYm$>#^4*4!zfرïLwMM rJtR>;W[ %BAD3T+ҫh-+W*+_WǶ(4RW /|_mjeR T{7CpZZ^[n7C$z\᏷vo,\?ZNE5[?:j Ύ3W|z7xnuG?DЋ:.f>JB+TRÇ2ix-һ`"^~)6c0=˅z:9%ˋs[q.{c/ws'lb̗"Y$3 \y^B = ZepT'O) ƾ3 P ;:lC*^-jba6Uwb&R;+[vpxkh:qARUf\&N,,$s=8r9={wfhsaig=y{ƽ١\'DPZE?S,O=1gb;ⷲ7J !e)Co!&Np;ˡX ^ڞmokbOpZC%ckR;7m]Mz[,>WodX_pbYU뼵)F@%@V"dhptdQsK` "d &ˍc;Yjy83I?o onhx΃367GѭuiYL@cuvؼ.8~suGv,2v8;]M0ٷs VRhƹOv}ڷ\_ڷf;\@QtbOJF}[n+Е Za(@8p~1Y"!=ָ{@I a9 6t!T먹z br6$jx7{v3>#5x RBTP(䢤6EV]EEDZ5ĥz1e*OGT$%`iޠ]IH(`q@N| *EN9'[1=vf嵤,ԃ܏:ũڂL)4 H b(]I.SmJmMq"_ԑuӪځ;-4*NMR#ޅ ,[|VnG l{d7`uI(NcOe7Bk͹w|pw@صiDNހl[af\Ν%I9օ))pyBj$&ILi:5c[y|MSw;5\ o4TIQ)Zu BszH HN7HT@SY$`ҴiRi'HHۡIzVc)sNCE!Quy4=(R&,7E](@%R1o^O{?`KZBwn8*L"{7Cg~zra-o'#]WEzSj\I5W'EvTQEJ]qdd $޼ Hy+FvCj5%;Bl. {Rv!^ m{ܯޜGGa &-ڲP28,P˥ eݎF.y<#] `7i[9$j ݷdq]n\W zX6!N[w P#?=lv_h\ktii~j\OSIY+t/f_Zs} p{=iAEjot]G2ͻwJM )S&I`Fkѳ~v].ڂZ!I$hBEMjtP2vGakah.`ݷQID5q> nҫ$Mu9w9a$Vcd+"{94-!ع- UkgWAEd| +v>ܼ.qT fi;RԠ߶TT`vj[sQRVĝgR %fNNBO@n 4䞊Kw!9lMipH^ @ 򩋍ޠ դY>UѲ( DR![N=(I$2my%T*vf)O֮+Ttp{JM{ ! 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\024\f\027\024\r\027\t\b \023\016\021\ \017 )Tj 0 Tw T* (\f\035\024\036\r \f\021\036\027\022\017 \032\036\035\031\007\024\004\027\ \024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026:)Tj 0.029 Tw T* (\251)Tj /Span<>> BDC [( )-238( )]TJ EMC 1 0 Td (\023\036\030\r\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\220\b\024\020\036\027\027\t\005, \024\021\030\026\ \032\026\036\021 \031\035\034\021\030\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\r\031\022\024\r\024\005 \f\017\020\027\026\035 \024\021 \f\035\017\017\ \f\021\024\005 \024\002\024\035\024\004\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017)Tj 0 Tw (-)Tj 0.326 Tw T* [(\030\031\036\021\f\016 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 4.71 0 Td [(\f\004\201\021 )0.5(\026\022\031\f\021\017\004\036\f\022\024\020\024 )0.5(\017\n\023\036\007\026\027\f\026 )0.6(\n\036\032\007\031 )]TJ 0 Tw -4.71 -1.218 Td (\023\030\024\f\r\036\021\024\n \024\030\020\026\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \f\021\036\027\022\024\005;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\r\021\024\030\024\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\024\220\b\024\020\036\027\027\t\005, \f\024\007\026\201\ \021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj (-)Tj 0.068 Tw T* [(\b\024\032\007\036\027\017\017 \031\035\034\021\030\026\r\031\022\026 )0.5(\004\036\030\036 \f\024\002\f\021\r\036\027\027\031\033 \n\t\001\036\004\ )]TJ 0 Tw (-)Tj T* (\027\031\033 \023\035\026\f\021\017\027\022\031 \f\035\017\017\f\021\024\ \005;)Tj 0.46 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )193( )]TJ EMC 1 0 Td (\021\030\036\021\017\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\220\b\024\020\036\027\027\t\005, \f\024\024\021\ \r\036\021\f\021\r\031\036\021 )Tj 0 Tw T* (\023\024\007\f\035\017\017\f\021\024\n\031 \f\035\024\033;)Tj 0.252 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-15( )]TJ EMC 1 0 Td (\004\036\021\r\201\030\021\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC [(\227 \020\017\023\024\220\b\024\020\036\027\027\t\005, )0.5(\023\030\036\007\f\021\026\r\035\016\036\021 )]TJ 0 Tw T* (\f\024\002\024\005 \n\t\001\036\004\027\031\033 \024\002\024\035\024\004\ \022\031 \(\n\t\001\036\004\027\t\005 \f\035\024\005\);)Tj 0.5 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )233( )]TJ EMC 1 0 Td (\023\016\021\t\005 \f\035\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \020\017\023\036\030\220\b\024\020\036\027\027\t\005, \220\021\024 \ \f\036\030\024\027\026\016 )Tj 0 Tw T* (\024\002\024\035\024\004\022\026.)Tj -0.041 Tw -1 -1.218 Td (\210\f\027\024\r\027\t\036 \220\027\007\024\f\024\027\024\020\030\026\235\ \017\004\036\f\022\017\036 \022\030\017\021\036\030\017\017 \007\035\016\ \017\027\021\030\026)Tj 0 Tw (-)Tj 0.082 Tw T* (\n\031\030\026\035\034\027\t\b \024\002\030\026\024\r\026\027\017\005 \r\ \022\035\033\004\026\033\021 \220\b\024\020\036\027\027\024\f\021\034, \220\ \b\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\021\030\031\022\021\031\030\031 \017)Tj /Span<>> BDC ( )Tj EMC (\220\b\024\f\035\024\005, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \017\f\b\024\007\017\021 \027\024\r\024\ \024\002\030\026)Tj 0 Tw (-)Tj 0.076 Tw T* (\024\r\026\027\017\036. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\024\027\024\020\030\026\235\017\017 \035\017\023\024\n\ \026 \024\023\030\036\007\036\035\016\036\021\f\016 )Tj -0.005 Tw T* [(\022\026\022 \017\027\021\036\027\f\017\r\027\024 \020\017\023\036\030\220\ \b\024\020\036\027\027\024\036, )0.5(\024\007\027\024\030\024\007\027\024\036 \024\002\030\026\024)]TJ 0 Tw (-)Tj 0.144 Tw T* [(\r\026\027\017\036, )0.5(\017\f\b\024\007\016\013\036\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.169 0 Td [(\021\030\036\021\034\036\020\024 )0.5(\(\023\024\007\f\035\017\017\f\021\024\020\024\) )0.6(\f\035\024\016 )]TJ ET q 42.52 570.6 209.764 166.408 re W n q /GS0 gs 209.7637708 0 0 167.523017 42.5196852 570.5821006 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.001 Tw 9 0 0 9 42.5197 559.7997 Tm [(\022\t\217\210\b\002\220 )0.5(4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\217\024\026\031\023\032 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 13.835 0 Td [(\240\027\f\031\026 )0.5(\024\021\027\023\027. )0.5(\035\022\033\031\026\020 )0.5(\025\022\024)]TJ 0 Tw (-)Tj -13.835 -1.2 Td (\200\031\030\t\212\027\235 \007\020\024\023\022 \030\021\027\025\020\030\ \006\020\023\022\033\027\032\024\023\025\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.304 Tw 0 -1.2 TD [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endopho)13(to. Ex)10(amination in white light. Lipoma )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the descending duodenum)Tj ET q /GS0 gs 212.5984234 0 0 170.3666824 42.5196877 346.5290695 cm /Im3 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.012 Tw 9 0 0 9 42.5197 335.619 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\025\030\031\203\031\023\031. \217\024\026\031\023\032 \021)Tj /Span<>> BDC ( )Tj EMC (\240\027\f\031\026 \024\021\027\023\027. \035\022\033\031\026\020 \024\022\ \b)Tj 0 Tw (-)Tj T* (\026\031\021\022\030\025\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.304 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Endopho)13(to. Ex)10(amination in white light. Lipoma )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the sigmoid colon)Tj ET q /GS0 gs 212.5984234 0 0 170.1267366 42.51968 122.5883513 cm /Im4 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.18 Tw 9 0 0 9 42.5197 111.77 Tm (\022\t\217\210\b\002\220 6.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\217\024\026\031\023\032 \021)]TJ /Span<>> BDC ( )Tj EMC [(\240\027\f\031\026 \024\021\027\023\027. )0.5(\205\022\026\033\023\031\026 )]TJ 0 Tw T* (\253\033\031\030\r\213\n\022\273 \f\022\033\031\026\013 \020\025\023\032\ \020\f\017\025\031\b\031 \031\023\030\027\f\020 \255\027\f\r\030\n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.131 Tw T* [(F)-16(igure )0.6(6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Endopho)13(to. )0.6(Ex)10(amination )0.6(in )0.5(white )0.6(light. )0.6(\253Cushion\273 )]TJ 0 Tw T* (sign of)Tj /Span<>> BDC ( )Tj EMC (antral lipoma)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 504.7145 56.0378 Tm (171)Tj ET endstream endobj 88 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;% ##   u!"1Qu2356Rr#AUaqSTbt $%&'()*4789:BCDEFGHIJVWXYZcdefghijsvwxyz?UU9Efb|z!4^Ff'Efb|z!D.:3B31>hO/D#3B31>hF`#\FB31>hO/D#0ئo0vSk@{arbZ>f'Efb|z!4^Ff'E}H2U*qsҊ*k9V4꤇וofys~Q۫'9-BN`M2"%b9>XqP:p*=IqGM< G&U*qsҊ$  /36_ͣ$`(D 9I >!|0h,riIX)$8`B!!a.(  Јl))FণSOKk OWJ@v &IS"@!@Cd^(JTE ) L ;v Cd*2htHIc'bZ;!%dPrǹL =v~aCJG.{)Mp@aVlSspR^4{mCJ6lq۱JyTi :rrYMMui5y R/ayvٲR݅hly\͒"B. it,'!F)jӇW>H<:ӌEX6𨦥Jٹd,%F8z$͗hI UVY Ђ 6Km4%c U*qsҊ^Gs}*d{d\۪,qEscoNHUo[Τx-\6Tc;v$Bk!CF+zBh/U3Gu#!XJXM21 Ra6؍t4/FA (dH!L F q˴5!WK:cQ1C}bazzT 3R:J7DE" j.u2Zr-D\ 8dì/n] za}.sLM8L0#R{DmL e@D|4O6UKD@rs@8; "P6Rle,2c}okv̛wB !kAYfƶ+7rj]mGM< G&U*qsҊ^Gs}*d{\۪,qEscoNH9(CJPab"1 KG(Ɩ; {*Om:!H}O'0Dlq)q(n Hq˴5"H1c2َ RhM% #E)ccXL#@4髪Y, #3ZW7@crQ@B& ĞpYtH69#!\wԇr.80T!q A$ytǧ<>ݧ.3&xZwYk4ɩwFꆍ4%c U*qsҊ@``qb w{Wp w{WDzI%r`+c *1a'<}+5|uRCkʌ{}b91 "#ٻiRʜADJb* DPP&1tasH;:fgT k&s^u "0BCiNc R`%۸cVK]H훤,E$Skٴ#2hw (s6":݄PmaWK]L[E(n.ckJsyKAt=nq$j@0w.^%EXO+/H(2Hc VO*5"1K}ܻj<&;qbK\x;Xl'8P&IH`($^0! :jέ"M`pƩ.8l0DLSIc4;A0)E \@B:ӇW>H7Ny}5ۦ/^(mqeZP])e^)e^ zbY9bb/N')P<ʽqFB4Vn.M di4NlBۅ. mh mh mh mh#3 d)YS1Tk cwGM< G&U*k`dzQZxZ*{:3#8Z*{:3#8Z*{:3#aOSU<"d51f(*AX+Z$LsR5$2ysqJẄ́T ""8aηIE)H(vjH@Gp5hL T&LsJ"%dUzBh$2H@Gu07E2y,H*ͪ+UȢ@Lc5 5M2,eڻrD*H K,q إ)6 †fWU˟QTU0 $!p)B zJe/tu T,`)@16DGzZkL#%P*\DcZ^5O :ĞmT$#}ZL9{b ISjF\Y,BqB:׉.'Ry0 tL8ɪp(&ئ59[պ1(37o%rAEWJ "A8@cEtHGm@-PeS:eDmskFLHpA3%),#[GS -T}=nGS -T}=nGS -T}=n zL%&E~f;DgHLS\C2U/k ݟs8u{8g8i1?3ZG}OÌ֑s8u{8g8_KXКQUNR&BA1aJ}qGKmX7;HPF5am4jʜdT1::'r4[t^rݝS,tBNe8HP VgY(U&z"ٱe%Y3 Kq#n"AOL֫˙% 9t"Q:*&9@  :=3b~E9TT٥IL'+fa 1Tt«+KR.\őQ"\p.b^ 4d%tfIH &@FׁYĹ ]-REQ" s9l[{V o+M$ЊJC,r GT͖3yc)"*C@@kF!1D@."6 A=)DƗ;ljJc P";Aݖg ^w6TԊvG+UY{1̊)@ len89RI"(q(\L"6ףTSnV#vVJG1P0a :fdβHT(ׄ`䓤*J0td~sJPDJ Gn.ddβ*SLsHF":Ig 2E"̢Ba"PƎ9v{~,iMz4H+"E2~}k[DG\궓 *K(#'8"#`׆^xRwẕᇅ(x^xRwfr:fNJ W**j bayOj<bEY Tt(FݤnE/`@sEQp&.8 kx4=+*irG5P !YY+)3v2"" a Bۂ2MSRx̡w"qda^h;j !G D%N-3*oR`qaÊ؂ڼ"Jp”{{MS\| x̬9B-aiY2}8`vMrR0Ȧu@%(ǿBFl,NvdΖ+׶ \dU*qsҊb5I$`ͩR1RZ!߱a19!Lc7T P(EzgKԭ̩Hj*T!`1"%\a;vHoI,JjPB&0<5B+9ېʪL&9d(k ԵJڥ8q*xIL[E!JU "a-!ֲ=|PA QCP 1Gtwf~ΰM)uTSL;vy֮^3&:먑$Q9 #IHJ&Joݚ\%٢gq+v!X(m5=|b=8,.95P"UM28 1J6SBڌo\PsVq,Y4QL(qb&0˰%-4|uREUo[Τx͛3LV]cL;@JdCONX,UjWr R&S Q0ZԌRYš`6̘a،vW,]̩I) He#;b@YiJ$SJjO2[HcPp$T(m{Xi2U0e,@W(%bu"*JT{4`d>b6rd. *xħ> r ۔)0@` ƺ_[RWrLPpvM2`y6pV@L`0@Db;EWUc#,_O5A%S>#lPּj[LT],F3. xhi4wC1bڷTF$zoL>8LQ!^nSU0&QĦ=Z$ea'vWZ]f<U*qsҊѕjd0 &`=lWm/S)aFQҵA5r(aıul&fPㄠ& oJ=ӄ"¢2p F(v;2`̙fI[k 4[$vbi/Y7NN 78$L (`"6)GXX>B^uL@)&8J"Me =+vƠp u}-*~i-$RӚeʙÄTdPb `lRzyW02b). a0v#i THXc5f6!SEMs XvH˗g$L[b+@L6 mldze|iJ?C,YJ8AĢ! 1`װmJqZ7pM'H@lR#C筥~lTa.#`\HPO.tu^?hVLjAM2 @T]ONg L݄]+0&c 1X6!F_zFhs'g;(@L;Aq Gv9Lx ?B,W{sGK'saM;6݉YqaⱰ:iRTLZLNĒ@)ba)=q'59Lw &t@>@!B(b\IR439k3=|I0Hs p `zOIu7Q092˕jE5S "`s'1TRio' )*$CR1bhɶ۵h,A(˜0kuIT4)4ɪ|Nk`sFE$s8XQMf:605RiNs/En$Nٙ8x@DJKNj%UFL\2dfb1=6YD4$KR5F<>g-lķ^qUr:?˙}M7j'lXx@A5.Pѱo:K”dU PֽFp³:Zɔbf#ĈbDP2*e1 ڎD]ֈuf@"e19 qi*SMtkk`CwZ?Hpd_1e.b8CV7+?n5ꄋ Uu4&EpQ( h."I)*:Ff֤ȳD8]b#`dKvN+(dRlCA9[FیEdAFMT^N騒7]S7;4UƑ.U/:|tą*qF 4唂i5 \$.3lPۘ"m])2q (1!lE q׾A\{9B%ҤWC)LT mqi\*(f<@J#\@,SA.@Z(،$P!;Q lqL1!l[_^xNͪY3VrteRzUNSؠ fmbҭD[x͑LGɩaDxUfMnQI4PΕ*V2s8kDc·wMAI)@g(UDԾ^\In,#w:SK>z! 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\023\030\017\027\026\022\026\ \n \035\017\023\024\n )Tj T* (\024\021\027\024\f\016\021\f\016:)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.169 Tw 1 0 Td (\253\217\t\214\212\003\002\214 \212\002\240\210\230\220\t\273)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf (\227 \235\024\030\n\017\030\024\r\026\027\017\036 \031\020\035\031\002\035\ \036)Tj 0 Tw (-)Tj 0.129 Tw -1 -1.218 Td (\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\036\030\b\027\024\f\021\017 \027\024\r\024\024\002\030\026\024\ \r\026\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\007\026\r\035\017)Tj 0 Tw (-)Tj 0.252 Tw 0 -1.218 TD (\r\026\027\017\017 \017\027\f\021\030\031\n\036\027\021\024\n \(\f\023\036\ \006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 98%, \004\031\r)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 40%\) [24];)Tj T* (\251)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.31 Tw 1 0 Td [(\253\217\t\214\212\003\002\214 )0.5(\230\004\003\006\004\273)]TJ /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 8.634 0 Td [(\227 )0.5(\024\021\f\031\021\f\021\r\017\036 )0.6(\f\r\016\036\005 )0.5(\n\036\032\007\031 )]TJ 0.579 Tw -9.634 -1.218 Td (\035\017\023\024\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\024\005, \030\ \036\026\035\017\031\033\013\036\036)Tj 0 Tw (-)Tj 0.238 Tw T* (\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\022\006\017\017 \f\035\017\017\f\021\024\005 \002\017\024\023\ \f\017\005\027\t\n\017 \013\017\023\006\026\n\017. )Tj -0.055 Tw T* (\215\024\035\024\032\017\021\036\035\034\027\t\005 \030\036\031\035\034\ \021\026\021 \b\026\030\026\022\021\036\030\017\031\036\021\f\016 \235\024\ \030\n\017\030\024)Tj 0 Tw (-)Tj 0.192 Tw 0 -1.218 TD (\r\026\027\017\036\n \021\030\036\031\020\024\035\034\027\024\005 \253\023\ \026\035\026\021\022\017/\001\026\021\030\026\273 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 )Tj 0 Tw 0 -1.218 TD (\024\002\024\035\024\004\022\017 \027\026\007 \023\024\r\036\030\b\027\024\ \f\021\034\033 \027\024\r\024\024\002\030\026\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([25];)Tj 0 -1.218 TD (\251)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0.121 Tw 1 0 Td [(\253\217\t\214\212\003\002\214 \002\206\b\004\202\t\230\r\n\002\217\235\ )0.5(\202\t\006\004\273)]TJ /Span<>> BDC ( )Tj EMC /T1_0 1 Tf (\227 \r\t\f\r\024\002\024\032)Tj 0 Tw (-)Tj 0.171 Tw -1 -1.218 Td (\007\036\027\017\036 \032\036\035\021\024\005 \032\017\030\024\r\024\005\ \021\022\026\027\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \f\021\031)Tj 0 Tw (-)Tj 0.121 Tw T* (\023\036\027\004\026\021\024\005 \002\017\024\023\f\017\017, \017\027\024\ \020\007\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\020\024 \024\023\024\030\024\032\027\036\027\017\016\ )Tj 0 Tw T* (\035\017\023\024\n\t [25].)Tj -0.083 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \b\026\030\026\022\021\036\030\027\t\b \023\ \030\017\027\026\022\024\r \007\035\016 \007\026\027)Tj 0 Tw (-)Tj 0.054 Tw T* (\027\024\020\024 \021\017\023\026 \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005, \r\t\016\r\035\016\036\n\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.077 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \n\036\021\024\007\ \024\r \r\017\031\026\035\017\026\006\017\017, \023\024\f\021\026\027\024\ \r\022\026 )Tj -0.018 Tw T* (\024\022\024\027\004\026\021\036\035\034\027\024\020\024 \007\017\026\020\ \027\024\026 \035\017\023\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031)Tj 0 Tw (-)Tj 0.111 Tw T* (\004\026\036\r \r\024\n\024\032\027\026 \021\024\035\034\022\024 \023\024\ \f\035\036 \220\027\007\024\f\024\027\024\020\030\026\235\017\004\036\f\022\ \024\020\024 )Tj 0 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 [24].)Tj /T1_1 1 Tf 0 -2.436 TD (\231\b\240\002\217\002\b\002\n\006\004\226\t\201\r\217\220\004\235 \217\r\ \214\t\002\003\t\220\004)Tj /T1_0 1 Tf 0.058 Tw 0 -1.218 TD [(\215\030\017 )0.5(\220\027\007\024\f\024\027\024\020\030\026\235\017\017 )0.6(\f\021\036\027\022\017 )0.6(\023\024\035\024\020\024 )0.5(\024\030\020\026\027\026 )0.5(\023\024\035\031\004\026\036)]TJ 0 Tw (-)Tj 0.054 Tw T* (\n\024\036 \023\024\f\035\024\005\027\024\036 \017\024\002\030\026\032\036\ \027\017\036 \f\024\024\021\r\036\021\f\021\r\031\036\021 \026\027\026\021\ \024\n\017)Tj 0 Tw (-)Tj 0.12 Tw T* (\004\036\f\022\017\n \f\035\024\016\n, \024\023\030\036\007\036\035\016\036\ \n\t\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\030\235\024\035\024\020\017\004\036\f\022\024\n )Tj 0.194 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\017 \(\f\035\017\017\f\021\026\016\ \024\002\024\035\024\004\022\026, \n\t\001\036\004\027\026\016 \023\035\ \026)Tj 0 Tw (-)Tj 0.075 Tw T* (\f\021\017\027\022\026 \f\035\017\017\f\021\024\005 \024\002\024\035\024\ \004\022\017, \023\024\007\f\035\017\017\f\021\t\005 \f\035\024\005, \n\ \t)Tj 0 Tw (-)Tj T* (\001\036\004\027\026\016 \024\002\024\035\024\004\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\024\027\026\016 \024\002\024\035\024\004\022\026\).)Tj 0.416 Tw T* (\232\017\f\035\024 \r\017\031\026\035\017\017\030\031\036\n\t\b \f\035\ \024\201\r \026\r\017\f\017\021 \024\021 \004\026\f\021\024)Tj 0 Tw (-)Tj 0.39 Tw T* [(\021\t )0.5(\031\035\034\021\030\026\r\031\022\024\r\024\020\024 )0.5(\f\022\026\027\017\030\024\r\026\027\017\016: )0.6(\004\036\n )0.5(\r\t\001\036 )0.5(\004\026)]TJ 0 Tw (-)Tj 0.181 Tw T* (\f\021\024\021\026, \021\036\n \002\024\035\034\001\036 \007\036\021\026\ \035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\201\r \n\024\032\027\024 \031\r\017\007\036\021\034. )Tj 0.341 Tw T* (\230\f\023\024\035\034\024\r\026\027\017\036 \f\021\026\027\007\026\030\ \021\027\t\b \031\035\034\021\030\026\r\031\022\024\r\t\b \220\027\007\024\ )Tj 0 Tw (-)Tj 0.386 Tw T* [(\f\022\024\023\024\r )0.5(\(\022\024\027\r\036\022\f\027\t\b )0.6(\017\035\017 )0.5(\030\026\007\017\026\035\034\027\t\b\) )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.462 0 Td (\004\026\f\021\024\021\024\005 )Tj 0.331 Tw -18.462 -1.218 Td (7,5\22612 \204\206\006 \023\024\r\024\035\016\036\021 \r\017\031\026\035\ \017\017\030\024\r\026\021\034 \022\026\022 \021\022\026\027\017 )Tj 0.021 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\n\017 \240\025\221 \(\004\026\f\021\024\021\ \026 7,5\22610 \204\206\006\), \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\031 )Tj 0.062 Tw T* (\f\026\n\024\020\024 \024\030\020\026\027\026 \(\004\026\f\021\024\021\026\ 10\22612)Tj /Span<>> BDC ( )Tj EMC (\204\206\006\), \023\030\036\007\f\021\026\r\035\036\027\027\031\033 )Tj 0 Tw T* (\023\016\021\017\f\035\024\005\027\024\005 \017\035\017 \007\036\r\016\021\ \017\f\035\024\005\027\024\005 \f\021\030\031\022\021\031\030\024\005 [2\ 6].)Tj 0.825 Tw T* (\212\035\016 \007\017\026\020\027\024\f\021\017\022\017 \017\027\021\030\ \026\n\031\030\026\035\034\027\t\b \024\002\030\026\024\r\026\027\017\005\ )Tj 0.152 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027\026\022\024\r\024\005 \220\235\235\036\022\021\017\r\027\ \024\f\021\034\033 \n\024\020\031\021 \017\f\023\024\035\034\024\r\026\021\ \034)Tj 0 Tw (-)Tj 0.155 Tw T* (\f\016 \022\026\022 \030\026\007\017\026\035\034\027\t\005, \021\026\022\ \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\r\036\f\022\f\027\t\005 \220\b\024\220\027\007\024\f\022\024\ )Tj 0 Tw (-)Tj 0.065 Tw T* (\023\t [27]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n )0.5(\024\021\007\036\035\036\027\017\017 )]TJ 0.054 Tw T* (\022\026\022 \022\024\027\r\036\022\f\027\024\020\024, \021\026\022 \017\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\007\017\026\035\034\027\024\020\024 \031\035\034\021\030\026\r\ \031\022\024\r\024\020\024 )Tj 0.288 Tw T* (\220\027\007\024\f\022\024\023\026, \027\036\f\022\024\035\034\022\024 \031\ \007\024\002\027\036\036 \017\f\023\024\035\034\024\r\026\021\034 \030\026\ \007\017)Tj 0 Tw (-)Tj 0.279 Tw T* (\026\035\034\027\t\005 \220\b\024\220\027\007\024\f\022\024\023, \023\024\ \f\022\024\035\034\022\031 \220\021\024\021 \026\023\023\026\030\026\021\ \017\n\036)Tj 0 Tw (-)Tj 0.23 Tw T* (\036\021 \021\024\030\006\036\r\031\033 \024\023\021\017\022\031, \017\027\ \026\004\026\035\034\027\024 \023\030\036\007\027\026\027\026\004\036\027\ \007\035\016 )Tj -0.027 Tw T* (\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \006\036\035\036\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\007\026\036\021 \001\017\030\024\022\017\n\017 \031\021\ \024\004\027\016)Tj 0 Tw (-)Tj 0.113 Tw T* [(\033\013\017\n\017 )0.6(\r\024\n\024\032\027\024\f\021\016\n\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.032 0 Td [(\024\027\024\005 )0.6(\024\f\n\024\021\030\026, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.504 0 Td [(\021\024\n )0.5(\004\017\f)]TJ 0 Tw (-)Tj 0.212 Tw -18.537 -1.218 Td (\035\036 \007\024\023\023\035\036\030\024\r\f\022\024\005 \024\006\036\027\ \022\024\005 \022\030\024\r\024\021\024\022\026. \025\024\027\r\036\022\f\ \027\t\005 )Tj 0.453 Tw T* (\220\b\024\220\027\007\024\f\022\024\023 \017\f\023\024\035\034\031\036\ \021\f\016 \023\036\030\r\t\n \(\017 \036\007\017\027\f\021\r\036\027)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\t\n\) \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \f\035\031\004\026\036, \036\f\035\017 \026\023\035\026\027\017\ \030\024\r\026\027\024 \r\t\023\024\035\027\036\027\017\036 )Tj ET q 303.307 570.597 209.764 166.411 re W n q /GS0 gs 209.7637708 0 0 167.523017 303.3071013 570.5795982 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.034 Tw 9 0 0 9 303.3071 559.7972 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\025\030\031\203\031\023\031. \217\024\026\031\023\032 \021)Tj /Span<>> BDC ( )Tj EMC (\240\027\f\031\026 \024\021\027\023\027. \035\022\033\031\026\020 \025\022\ \255)Tj 0 Tw (-)Tj 0 -1.2 TD (\025\027\b\032\r\030\025\031\b\031 \031\023\030\027\f\020 \033\022\212\027\ \021\031\030\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.04 Tw T* [(F)-16(igure )0.5(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. )0.5(Ex)10(amination )0.5(in white light. )0.5(Lipoma )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0 Tw T* [(low)12(er thoracic esophagus)]TJ ET q 303.307 346.527 212.598 170.366 re W n q /GS0 gs 212.5984234 0 0 170.3666824 303.3070679 346.5266281 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.05 Tw 9 0 0 9 303.3071 335.6197 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \230\025\030\031\203\031\023\031. \217\024\026\031\023\032 \021)Tj /Span<>> BDC ( )Tj EMC (\240\027\f\031\026 \024\021\027\023\027. \035\022\033\031\026\020 \020\025\ )Tj 0 Tw (-)Tj T* (\023\032\020\f\017\025\031\b\031 \031\023\030\027\f\020 \255\027\f\r\030\ \n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.044 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13.1(to. Ex)9.9(amination in white light. Lipoma of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj 0 Tw T* (antrum of)Tj /Span<>> BDC ( )Tj EMC (the stomach)Tj ET q /GS0 gs 212.5984234 0 0 170.1267366 303.3070984 122.5889921 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.001 Tw 9 0 0 9 303.3071 111.7701 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \230\025\030\031\203\031\023\031. )0.5(\217\024\026\031\023\032 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 13.835 0 Td [(\240\027\f\031\026 )0.5(\024\021\027\023\027. )0.5(\035\022\033\031\026\020 )0.5(\025\022\024)]TJ 0 Tw (-)Tj -13.835 -1.2 Td (\200\031\030\t\212\027\235 \007\020\024\023\022 \030\021\027\025\020\030\ \006\020\023\022\033\027\032\024\023\025\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.304 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Endopho)13(to. Ex)10(amination in white light. Lipoma )]TJ 0 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (the descending duodenum)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8276 56.0378 Tm (170)Tj ET endstream endobj 306 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,^""  !1AQaq"2#Bb $%&'()*3456789:CDEFGHIJRSTUVWXYZcdefghijrstuvwxyz!1AQa"q2B$Rr #%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijstuvwxyz?RI%tЄ$I!BI$!U%WzЮю HzV77VK´4 kF^ҾH.E +Kd\%q;*NTNƽ#@zCk-wh;Mպk=gQ0exf4ڷNhF6oQe8?p^ 0m&^&IC` 5+@<Mh`ݛMFunz]=f:CP ) zL0LpE !B 1\hS &0Bd!RI4PbRꬄ! jYFZetn82D6R)B2FIw N(tAL$!QiID{q驩"OT.ӧ/MA^i]:Wc>I:9I$v*]HI$B(BI$!I$B!RI%tЄ$I!Bp 0*Jewt$pH s;V!nCVM< *U4UDH$X3%I^oV,}[ti:Z/v;giEm1a "L;ԠCK1I9PhсH ˳9otw-#pj ;2jPoGv<UJO"ZvRk W*NԚ.BU jZQD$ʄB)ÆiĚҊ$M6**IBi9ѷ$(\e B֪x:DQJB)KH8faR$BbNQ<4p BnT$ qk\dXSbB:/qGHZ0|nO2zB'<zLIs3Λ. 2Wd!R ܁ wђڙqQ@֦BI%HLd)hq:Atԩ!D;HgfykB Nհ)8@5PKYBNxQA)_jm"% T)ISDL"*HB$l@`&LQ0\ (`^ڣM)e.!B5j_5/7Ic4FeF(#%huT)d*@2ţe~$kBʄALdtT-Ztuk2zq8l9'j@vw#6U!H[Nට[tuu_[tU/  *^ɯ$-#NV+Kqa'OO "o`rOE$ςcd.|*2*cK!fF)45S$Iˋ\*UTI! 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Re)11(vie)11(w\))]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 711.1159 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc 0.166 Tw 8 0 0 8 42.5596 731.2159 Tm [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.171 Tw 14.347 0 Td [( V)33(aler)-37(iia I. Ryabtsev)16.1(a, P)114(. Her)-40(tsen Moscow Oncology R)21(esearch Institute \(MORI\), 2nd Bo)13(tkinsky p)46(roezd, 3, )]TJ 0.023 Tw -14.352 -1.2 Td [(Moscow)52(, 125284, R)22(ussia; e-mail: v)16(aler)-42.9(yappv@gmail.com)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 05.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 05.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 651.7618 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc -0.035 Tw 10 0 0 10 42.5197 627.4058 Tm (\214\017\023\024\n\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\ \027\201\027\027\024\036 \017\027\021\030\026\n\031\030\026\035\034)Tj 0 Tw (-)Tj 0.003 Tw 0 -1.218 TD (\027\024\036 \027\024\r\024\024\002\030\026\024\r\026\027\017\036 \n\036\ \036\027\b\017\n\026\035\034\027\024\020\024 \023\030\024\017\f\b\024\032\ \007\036)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\017\016, \n\036\007\035\036\027\027\024 \030\026\r\017\r\026\033\013\ \036\036\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\030\024\r\024\005 \021\022\026\027\017 [1]. )Tj 0.017 Tw T* (\212\026\027\027\t\036 \024\023\031\b\024\035\017 \n\024\020\031\021 \r\f\ \021\030\036\004\026\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \024\030\020\026\027\026\b, )Tj 0.106 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\n \021\ \030\026\022\021\036 \(\240\025\221\), )Tj 0.052 Tw T* (\024\007\027\026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\240\025\221 \035\017\023\024\n\t \007\017\026\020\027\024\f\021\017\030\ \031\033\021\f\016 \027\026\004\017\021\036\035\034\027\024 )Tj 0.059 Tw T* [(\030\036\032\036, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\017\b )0.5(\007\024\035\033 )0.5(\023\030\017\b\024\007\017\021\f\016 )0.5(\024\022\024\035\024 )0.5(4\2265% \024\021 )0.5(\024\002\013\036\020\024 )]TJ 0 Tw T* (\004\017\f\035\026 \007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\ \t\b \024\002\030\026\024\r\026\027\017\005 [2].)Tj 0.025 Tw T* [(\221\026\022, \002\024\035\034\001\017\027\f\021\r\024 )0.5(\035\017\023\024\n \240\025\221 )0.5(\024\002\027\026\030\031\032\017\r\026\033\021\f\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj 0.055 Tw T* (\f\021\024\005 \022\017\001\022\036 \(60\22675%\))Tj /Span<>> BDC ( )Tj EMC [(\227 \027\026\017\002\024\035\036\036 \021\017\023\017\004\027\t\n )0.5(\n\036\f\021\024\n )]TJ 0.329 Tw T* (\035\024\022\026\035\017\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\030\020\026\027\036 \016\r\035\016\033\021\f\016 \r\024\ \f\b\024\007\016\013\026\016 )Tj 0.072 Tw T* [(\024\002\024\007\024\004\027\026\016 )0.5(\(45%\) \017)]TJ /Span<>> BDC ( )Tj EMC 8.348 0 Td [(\f\017\020\n\024\r\017\007\027\026\016 )0.5(\(30%\) \022\017\001\022\017, )0.5(\021\024\020\007\026 )]TJ 0.187 Tw -8.348 -1.218 Td (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\f\b\024\007\016\013\036\005 \024\002\024\007\024\004\027\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\024-\024\002\024\007\024\004)Tj 0 Tw (-)Tj 0.068 Tw T* (\027\024\005 \022\017\001\022\026\b \024\027\017 \r\f\021\030\036\004\026\ \033\021\f\016 \030\036\032\036 \(\023\030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (15% )Tj 0.08 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (9% \f\035\031\004\026\036\r, \f\024\024\021\r\036\021\f\021\r\036\027\027\ \024\) [3]. \025\030\024\n\036 \021\024\020\024, \024\023\017)Tj 0 Tw (-)Tj 0.31 Tw T* (\f\026\027\t \036\007\017\027\017\004\027\t\036 \f\035\031\004\026\017 \035\ \017\023\024\n\026\021\024\026 \021\024\035\f\021\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.348 Tw T* [(\022\017, \022\024\021\024\030\t\005 \n\024\032\036\021 \023\030\024\016\ \r\035\016\021\034\f\016 )0.5(\027\036\f\023\036\006\017\235\017\004\036\f\022\024\005 )]TJ 0.271 Tw T* [(\f\017\n\023\021\024\n\026\021\017\022\024\005 )0.5(\253\024\f\021\030\024\020\024 \032\017\r\024\021\026\273 \017)]TJ /Span<>> BDC ( )Tj EMC (\n\026\f\022\017\030\024\r\026\021\034\f\016 )Tj 0.316 Tw T* (\023\024\007 \007\030\031\020\017\036 \026\002\024\035\036\r\026\027\017\ \016 [30]. \200\021\024\030\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 )Tj 0.096 Tw T* (\024\030\020\026\027\024\n, \020\007\036 \035\024\022\026\035\017\031\033\ \021\f\016 \035\017\023\024\n\t, \016\r\035\016\036\021\f\016 \021\024\027\ \022\026\016 )Tj 0.047 Tw T* (\022\017\001\022\026 \(\024\022\024\035\024 30%\). \222\024\020\035\026\f\ \027\024 \035\017\021\036\030\026\021\031\030\027\t\n \007\026\027\027\t\ \n, )Tj 0.085 Tw T* (\002\024\035\034\001\026\016 \017\b \004\026\f\021\034 \235\024\030\n\017\ \030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\r\007\024\001\027\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.169 Tw T* (\022\036 \(\007\024 20%\), \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 )Tj 0.041 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.791 0 Td [(\021\024\013\036\005 )0.6(\022\017\001\022\026\b )0.6(\017\b )0.6(\007\024\035\016 )0.6(\027\036\r\036\035\017\022\026 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.457 0 Td [(\f\024\f\021\026\r\035\016\036\021 )0.6(\035\017\001\034 )]TJ 0.293 Tw -15.249 -1.218 Td (10% [4]. \200)Tj /Span<>> BDC ( )Tj EMC (\007\r\036\027\026\007\006\026\021\017\023\036\030\f\021\027\024\005 \022\ \017\001\022\036, \007\024\f\021\031\023\027\024\005 )Tj 0.43 Tw T* (\024\f\n\024\021\030\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\024\235\026\020\024\020\026\f\021\030\024\007\031\024\007\036\027\024\ \f\022\024\023\017\017 \(\233\206\212\222\), )Tj 0.116 Tw T* (\024\023\031\b\024\035\017 \004\026\013\036 \024\023\030\036\007\036\035\ \016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\036\036 \027\017\f\b\024\007\016\013\036\005 \004\026\f\021\017 )Tj -0.01 Tw T* (\(D2\) [5,6]. \200)Tj /Span<>> BDC ( )Tj EMC (\023\017\013\036\r\024\007\036 \035\017\023\024\n\t \r\t\016\r\035\016\033\ \021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (10\22612% )Tj 0.035 Tw T* (\023\026\006\017\036\027\021\024\r, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n)Tj /Span<>> BDC ( )Tj EMC (\227 \024\027\017, \023\030\036\017\n\031\013\036\f\021\r\036\027\027\024\ , \035\024\022\026)Tj 0 Tw (-)Tj -0.007 Tw T* (\035\017\031\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\001\036\005\027\024\n \017\035\017 \r\036\030\b\027\036\020\030\031\007\ \027\024\n \024\021\007\036\035\026\b [6,7]. )Tj 0.069 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \035\017\023\024\n\t \f\024\f\021\026\r\035\ \016\033\021 \n\036\027\036\036 1% \024\021 \r\f\036\b \027\024)Tj 0 Tw (-)Tj -0.043 Tw T* (\r\024\024\002\030\026\024\r\026\027\017\005 \220\021\024\020\024 \024\030\ \020\026\027\026, \017)Tj /Span<>> BDC ( )Tj EMC (\r \002\024\035\036\036 \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (75% \f\035\031)Tj 0 Tw (-)Tj 0.154 Tw T* (\004\026\036\r \030\026\f\023\024\035\026\020\026\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\030\026\035\034\027\024\n \024\021\007\036\035\036 [5,6]. \025\ \026\022 )Tj 0.032 Tw T* [(\023\030\026\r\017\035\024, \035\017\023\024\n\t \240\025\221 \030\026\f\ \023\024\035\026\020\026\033\021\f\016 )0.5(\017\027\021\030\026\n\031\030\026\035\034\027\024 )]TJ 0.21 Tw T* (\(90\22695%\), \f\031\002\f\036\030\024\027\024\036 \030\026\f\023\024\035\ \024\032\036\027\017\036 \027\026\002\035\033\007\026\036\021\f\016 )Tj 0 Tw T* (\027\026\004\017\021\036\035\034\027\024 \030\036\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (5\22610% \f\035\031\004\026\036\r [10].)Tj 0.024 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \023\026\021\024\ \020\036\027\036\021\017\004\036\f\022\017\005 \n\036\b\026\027\017\n \235\ \024\030)Tj 0 Tw (-)Tj 0.112 Tw T* (\n\017\030\024\r\026\027\017\016 \035\017\023\024\n \024\030\020\026\027\ \024\r \240\025\221 \017)Tj /Span<>> BDC ( )Tj EMC (\235\026\022\021\024\030\t \030\017\f\022\026 \017\b )Tj 0.29 Tw T* (\030\026\r\017\021\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\f\017\b \023\024\030 \007\024\f\021\024\r\036\030\027\024 \027\036 \031\ \f\021\026\027\024\r\035\036\027\t. )Tj 0.019 Tw T* [(\210\007\027\026\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.963 0 Td [(\035\017\021\036\030\026\021\031\030\036 )0.6(\024\023\017\f\026\027\026 )0.5(\026\022\024\027\024\n\036\030\027\024\f\021\034 )0.6(\031\r\036\035\017)]TJ 0 Tw (-)Tj -0.024 Tw -3.963 -1.218 Td (\004\036\027\017\016 \004\017\f\035\026 \r\t\016\r\035\016\036\n\t\b \035\ \017\023\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\030\036)Tj 0 Tw (-)Tj 0.092 Tw T* (\027\017\036\n \017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\n \027\026\002\024\030\036 \017\n\017 \n\026\f\f\t \ \021\036\035\026 [11]. )Tj -0.002 Tw T* (\025\026\022 \023\030\026\r\017\035\024, \220\021\024\021 \021\017\023 \027\ \024\r\024\024\002\030\026\024\r\026\027\017\005 \024\030\020\026\027\024\ \r \240\025\221 )Tj 0.603 Tw T* (\027\036 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \022\035\017\ \027\017\004\036\f\022\024\005 \f\017\n\023\021\024\n\026\021\017\022\024\ \005, )Tj 0.006 Tw T* (\023\030\024\021\036\022\026\036\021 \002\036\f\f\017\n\023\021\024\n\027\ \024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\027\026\030\031\032\017\r\026\036\021\f\016 \f\035\031\004\026\005\ \027\024 )Tj 0.076 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\024\n \220\027\007\024\f\022\024\023\017\004\036\f\ \022\024\n \024\002\f\035\036\007\024\r\026\027\017\017 [6,9]. )Tj 0.224 Tw 23.244 57.237 Td (\210\007\027\026\022\024 \027\026\035\017\004\017\036 \024\023\031\b\024\ \035\017 \002\024\035\034\001\017\b \030\026\n\036\030\024\r \n\024\032\ \036\021 )Tj 0.536 Tw T* (\023\030\024\016\r\035\016\021\034\f\016 \030\016\007\024\n \027\036\f\023\ \036\006\017\235\017\004\036\f\022\017\b \f\017\n\023\021\024\n\024\r. )Tj 0.02 Tw T* (\203\026\023\030\017\n\036\030, \035\017\023\024\n\t \023\017\013\036\r\024\ \007\026 \n\024\020\031\021 \b\026\030\026\022\021\036\030\017\024\r\026\ \021\034)Tj 0 Tw (-)Tj 0.326 Tw T* (\f\016 \007\017\f\235\026\020\017\036\005, \030\036\020\031\030\020\017\021\ \026\006\017\036\005 \f\024\007\036\030\032\017\n\024\020\024, \002\024\035\ \034\033 )Tj 0.12 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(\220\023\017\020\026\f\021\030\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 11.506 0 Td [(\021\026\022\032\036 )0.5(\022\030\024\r\024\021\036\004\036\027\017\016\n\017, )]TJ 0.008 Tw -12.333 -1.218 Td [(\030\026\r\017\r\026\033\013\017\n\017\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.144 0 Td [(\r\017\007\031 )0.5(\017\255\016\r\035\036\027\017\016 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024)]TJ 0 Tw (-)Tj -0.037 Tw -8.144 -1.218 Td [(\035\024\004\022\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\r\036\030\b\027\024\f\021\017 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 )0.5([13]. \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\035\024)Tj 0 Tw (-)Tj 0.055 Tw T* (\022\026\035\017\026\006\017\017 \035\017\023\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\022\036 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \021\026\022\032\036 \n\024)Tj 0 Tw (-)Tj 0.27 Tw T* (\032\036\021 \027\026\002\035\033\007\026\021\034\f\016 \022\035\017\027\ \017\004\036\f\022\026\016 \022\026\030\021\017\027\026 \r\021\024\030\017\ \004\027\024\020\024 )Tj 0.079 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\030\024\b\024\007\017\n\024\f\021\017 \023\030\024\f\r\036\021\ \026 \r\r\017\007\031 \036\020\024 )Tj 0.006 Tw T* [(\f\021\036\027\024\017\030\024\r\026\027\017\016 )0.6(\022\030\031\023\027\t\n )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\036\n )0.5([11,12]. )]TJ 0.317 Tw T* (\230\027\021\030\026\n\031\030\026\035\034\027\t\036 \035\017\023\024\n\t\ \021\024\027\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0.221 Tw T* (\017\n\036\033\021 \f\b\024\032\031\033 \022\035\017\027\017\004\036\f\022\ \031\033 \022\026\030\021\017\027\031: \022\026\022 \023\030\017\r\017\035\ \024, )Tj -0.027 Tw T* (\023\026\006\017\036\027\021\t \023\030\036\007\255\016\r\035\016\033\021\ \032\026\035\024\002\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\022\024\n\235\024\030\021 \r)Tj /Span<>> BDC ( )Tj EMC (\220\023\017)Tj 0 Tw (-)Tj 0.307 Tw T* [(\020\026\f\021\030\017\017, )0.5(\027\026\035\017\004\017\036 )0.6(\023\030\017\027\026\022\024\r )0.6(\032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024\ )]TJ 0.024 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\036\n\017\017 [16]. \025\030\024\n\036 \021\024\020\024, \035\017\ \023\024\n\026 \n\024)Tj 0 Tw (-)Tj 0.063 Tw T* (\032\036\021 \017\n\036\021\034 \253\023\f\036\r\007\024\027\024\032\022\ \031\273)Tj /Span<>> BDC ( )Tj EMC (\227 \007\031\023\035\017\022\026\021\031\030\031 \f\035\017\017\f\021\024\ \005 )Tj 0.148 Tw T* (\024\002\024\035\024\004\022\017, \023\030\036\007\026\033\013\031\033 \036\ \005 \023\024\007\r\017\032\027\024\f\021\034 [10,11]. \221\026\022, )Tj 0.189 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\002\017\030\024\r\026\027\017\017 \024\023\031\b\024\ \035\017, \027\026\023\030\017\n\036\030, \004\036\030\036 \023\017)Tj 0 Tw (-)Tj 0.153 Tw T* (\035\024\030\017\004\036\f\022\017\005 \022\026\027\026\035, \n\024\032\036\ \021 \030\026\r\017\021\034\f\016 \024\002\f\021\030\031\022\006\017\016\ \036\020\024 )Tj 0.223 Tw T* (\023\030\024\f\r\036\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036\n \f\023\036\006\017\235\017\004\036\f\022\024\ \005 \022\035\017\027\017\004\036\f\022\024\005 )Tj 0 Tw T* (\f\017\n\023\021\024\n\026\021\017\022\017 [5,17,18].)Tj /T1_5 1 Tf 0 -2.436 TD (\231\b\240\002\217\220\002\212\t\201\r\217\220\004\235 \217\r\214\t\002\003\ \t\220\004)Tj /T1_4 1 Tf 0.281 Tw 0 -1.218 TD [(\233\027\007\024\f\022\024\023\017\004\036\f\022\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 \(\r \004\026\f\021\027\024\f\ \021\017, )0.5(\233\206\212\222 )]TJ 0.232 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\022\024\035\024\027\024\f\022\024\023\017\016 )0.5(\(\025\222\)\) \026\027\017\n\026\036\021 )0.5(\024\007\027\024 \017)]TJ /Span<>> BDC ( )Tj EMC 18.028 0 Td (\022\035\033\004\036\r\t\b )Tj 0.179 Tw -18.028 -1.218 Td (\n\036\f\021 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \017\027\021\030\026\n\031\030\ \026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026)Tj 0 Tw (-)Tj 0.162 Tw T* (\027\017\005 \024\030\020\026\027\024\r \032\036\035\031\007\024\004\027\ \024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026, \r\022\ \035\033\004\026\016 )Tj 0.027 Tw T* (\035\017\023\024\n\t. \233\021\024\021 \n\036\021\024\007 \023\024\r\024\ \035\016\036\021 \024\023\030\036\007\036\035\017\021\034 \n\026\022\030\ \024\f\022\024)Tj 0 Tw (-)Tj 0.006 Tw T* [(\023\017\004\036\f\022\017\036 \b\026\030\026\022\021\036\030\017\f\021\017\ \022\017 )0.5(\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\r\t\023\024\035)Tj 0 Tw (-)Tj -0.027 Tw T* [(\027\017\021\034 )0.5(\007\024\023\024\035\027\017\021\036\035\034\027\t\036 )0.6(\017\027\f\021\030\031\n\036\027\021\026\035\034\027\t\036 )0.6(\021\036\f\021\t )0.6(\007\035\016 )0.5(\017\b )]TJ 0 Tw T* (\r\036\030\017\235\017\022\026\006\017\017.)Tj 0.085 Tw T* (\230\027\021\030\026\n\031\030\026\035\034\027\t\036 \027\024\r\024\024\002\ \030\026\024\r\026\027\017\016 \r\f\036\b \023\024\035\t\b \024\030\020\ \026)Tj 0 Tw (-)Tj 0.132 Tw T* (\027\024\r \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\ \024\020\024 \021\030\026\022\021\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\022\024\n \024\f\n\024\021\030\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\036\035\024\n \f\r\036\021\036 \007\036\n\024\027\f\021\030\017\030\ \031\033\021 \f\b\024\032\017\036 )Tj 0.216 Tw T* (\023\030\017\027\026\022\017. \210\002\t\004\027\024 \021\026\022\017\036\ \024\002\030\026\024\r\026\027\017\016 \017\n\036\033\021 \023\024\035\ \031)Tj 0 Tw (-)Tj 0.215 Tw T* [(\f\235\036\030\017\004\036\f\022\031\033 )0.6(\017\035\017 )0.5(\023\024\035\031o\ro\017\007\027\031\033 )0.6(\235\024\030\n\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.534 0 Td (\023\024\022\030\t\021\t )Tj 0.486 Tw -18.534 -1.218 Td (\027\036\017\n\036\027\201\027\027\024\005 \f\035\017\017\f\021\024\005\ \024\002\024\035\024\004\022\024\005 [21]. \210\007\027\024\005 )Tj -0.035 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.142 0 Td [(\027\026\017\002\024\035\036\036 )0.5(\f\023\036\006\017\235\017\004\036\f\022\017\b )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022 )0.6(\035\017\023\024\n )0.5(\016\r)]TJ 0 Tw (-)Tj 0.068 Tw -1.142 -1.218 Td (\035\016\036\021\f\016 \017\b \032\036\035\021\024\r\026\021\t\005 \024\021\ \021\036\027\024\022, \022\024\021\024\030\t\005 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.146 Tw T* [(\035\017\004\017\036\n )0.6(\026\007\017\023\024\006\017\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 8.633 0 Td [(\227 )0.5(\032\017\030\024\r\t\b )0.6(\022\035\036\021\024\022, )0.5(\253\023\030\024\f\r\036\004\017)]TJ 0 Tw (-)Tj 0.008 Tw -8.633 -1.218 Td [(\r\026\033\013\017\b\273 )0.6(\004\036\030\036 )0.5(\f\035\017\017\f\021\031\033 )0.5(\024\002\024\035\024\004\022\031 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 16.956 0 Td (\007\024\f\021\026\021\024\004\027\024\005 )Tj 0 Tw -16.956 -1.218 Td (\017\027\f\031\235\235\035\016\006\017\017 \r\024\007\031\b\024\n \(\217\ \017\f. 1\2265\) [7,20].)Tj 0.246 Tw T* (\212\035\016 \024\023\030\036\007\036\035\036\027\017\016 \022\024\027\f\ \017\f\021\036\027\006\017\017 \024\023\031\b\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\036\201 \r\026)Tj 0 Tw (-)Tj 0.249 Tw T* (\017\n\024\f\r\016\017 \f\024 \f\035\024\016\n\017 \f\021\036\027\022\017\ \024\030\020\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 )Tj 0.555 Tw T* [(\023\030\026\022\021\017\022\036 )0.5(\001\017\030\024\022\024 )0.5(\023\030\017\n\036\027\016\036\021\f\016 )0.5(\017\027\f\021\030\031\n\036\027\021\026\035\034\027\026\016 )]TJ 0.141 Tw T* [(\253\023\026\035\034\023\026\006\017\016\273 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \017\b )0.5(\002\017\024\023\f\017\005)]TJ 0 Tw (-)Tj 0.246 Tw T* (\027\t\b \013\017\023\006\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (6\). \233\021\024 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\t\b \023\030\024\f\021\t\b )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td 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S`%?r >| __ZN}yew„ 褺 lۙ|ԯ> 7đ˶%YU;j[ =ʪGF̫S"ch]J2/=97B VcAvIIpp}~x5ZAcD|$:rֶ.#5]0~Ե?0nD4J|~Gk/wGQUvnqM7Nn7{X+ Sp[$ߩ*aNI^5.3gTi@t/?]g} [H7ߐ/y7 Gt<}bEe(U |Yȋ$Z!2_mZZF(hʊf-qOmwOާ \P*>Zc0L>Vs[4_̐ '4ʯ $A qo3ps>\0Ia6x$f9j,Kxz9c)5XY[Q$c]V/ᢿQ_AQ\y|nG;؛nӽb-Rch\M4bP񾢘E \}Ms2Í(YϨ1jck`B7#>и97c`LWOC n{.5 /!:N|\i+mr:#/Laeo3ʈDՈF?aȺ@ց}I4&$';ts۬(F[o{ 0"&\bz0TR]X_c$xj&W>=ψvv$А r]thRz N q6Of*M^ЮiKߓK.v`".; \KNI"EtPq q&[dKA3:I,,q, 9"D>8]tNx;#7e?׷Wyj"Nx&%U^kYDܜy$:>^cMʞqɋ]kI`.J[8т(;~"3ښV)+>B_TnYQ?ـͤ+p: ܯJ~Mz0BaU?X?jȀ2`wGާ !|)ŬЯV(xpue\ܺ L&4Zm&MA#{N՛ShkYĕ="We8)$ ZNC.՝G6zes>C~ٍ\0X]ܵ_PNYsd0sQ,- e-g |BQp#;xT!66*~cD(4lsדtdSvвYHÛi8l G)$/JC/sGQfˬJ_HؼA~'lD><K! 'n,#cqZ)-kD<]9=  V$[x-X!~9rI8&aq!NϦ;a{k-,ڵ+\|`!gmlW\Φ3nӂGE*]edkKc6.H x+x 5stu`B9DsnN`IAm$I$?6v64Q~cV=gb'0{_K?Jm)ٜ{*:vy&zE@ɬ /v* oAATlkK|soo5nOlb.#%xKt-`bQF0y?"n &E/h8ڂ\0A(=փ)0j2zYB rUdAWrt;9ctދL+Rs0 O13/ O^p&MXm,}*6‘eˤR Z,iQO/ @J9Mo~U~+WRx/;tweyV}v  |މnuj])>7QWJ1sQE7mYPq8މCk9yݙG[h(U))_GlQE/29䩣iBuODM!X9kТ1^Oco] S;z|"|goi4j]]KVSuk1ѓ.0)-lf*%=KFD RTs"r.jx,So8> g][ޓuz,[ngvޝqi p83R[pJD)RUGχв T!BF:Kmp'R-Dى7*SR!C7/5(9`n'!wLiPL4jZ6hD#Evea, "کQ IhUhS2/楝/&kP*NKfVBViK|wza` Ev'\RY_Na&:-e=7tݻ?jƃxJ -&ə&$-f-AM"R)IVY=e:rLWm%8U32H ߸–~IT8F歱B#Ksc 5#1#Yը&wGz.:i8nbY밬5Q4l&zr#~?䇨@N(=Q6wF獷;\ C6A_Ȏ_ā%Qe( x\^lg;Y/cS!#8}p9挸~ע\45|&WGX"_ai n$ cԛz``ev|~M:z_OzX8%;!sl]w4ĹDT _8Ym]@Kx *կ47IJw4;Iېe[(F1 *AOJ>%rj컱Kԧpq(_j{p;fK!?h+2gP[x'۵QWp No1b ډqPPa>vJw4 0)yDˏkW'C,Zݼm۳Z O0klf1OG%ewgC}?_vWWz Z.2QtK!bN xp䟄 WtT\m1n 1 N"W5USH~uc%G%][tc F&)F 4ʬޕIޣW2a. GQ*#%=2G:cX[L 5弛Q95iq43@ou_NPy4k*ޢOa VIoC7:OUKTEe/όq-̌aKkpC[IduHeDp!C.=l(\~%F2#1 NM9R9ɾ=_\@O6yh߁q4<# yaKsBv:5q*3qƪ&G%|uH&Z  VHHόI)l.ZR ֲ?_OtLqcjE _aae ǒhc;ώ8=`4AwˬI,O:Z[c+O}ӽNGSD>)lDZ֚P1kNRᅾTWϫ HEd,:TTO?@,< 6:ݼo͌,0::՛!W{)Ifwŏ?EUN*V,rVh VoX|uz&%O I)IЮHI^e%68]trd8@6K74ZwLW]s3A:IY @5F2/2fL$6z4lI{liV09 ta}IMTPa #v!EZ(5gFnbn¬bm: r-5}Wt и#P,REJĻr s8_$ !'] ӷӋnՠt^v?{pڻkwEEZqºBZ"T endstream endobj 303 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 743.0544 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 743.0544 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 696.2466 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 696.2466 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 154.7623 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 154.7623 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 107.9545 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 107.9545 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.033 Tc 0.168 Tw 8 0 0 8 70.9061 731.2159 Tm [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_1 1 Tf 0.023 Tc 0.173 Tw 9.34 0 Td ( \207\031\030\007\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\222., \202\005\030\026\023\036\021\016\027)Tj /Span<>> BDC ( )Tj EMC (\203.\202., \200\026\035\017\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\230.\217., \206\r\024\007\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\024\030\024\035\036\r)Tj /Span<>> BDC ( )Tj EMC (\206.\202., \215\026\022\035\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\016\002\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC [(\200.\230.,)23( )]TJ 0.017 Tc -0.034 Tw -9.345 -1.2 Td (\202\020\036\005\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC 4.217 0 Td [(\203.\200., )0.6(\206\031\f\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 5.277 0 Td [(\213.\200., )0.6(\230\r\026\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 5.476 0 Td [(\230.\230., )0.6(\025\024\030\032\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 6.292 0 Td [(\230.\224., )0.6(\214\024\b\n\026\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.775 0 Td [(\204.\204., )0.6(\203\017\022\024\035\026\005\004\031\022)]TJ /Span<>> BDC ( )Tj EMC 7.725 0 Td [(\221.\200., )0.6(\215\036\030\235\017\035\034\036\r)]TJ /Span<>> BDC ( )Tj EMC 7.068 0 Td [(\230.\207., )0.6(\215\017\030\024\020\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.063 0 Td [(\222.\222., )0.6(\222\017\007\024\030\017\027)]TJ /Span<>> BDC ( )Tj EMC 5.862 0 Td [(\200.\200.,)17( )]TJ 0.023 Tc 0.09 Tw -54.754 -1.2 Td (\222\021\026\030\004\036\027\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\212. \212\017\026\020\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \035\017\023\024\n \032\036\035\031\007\024\ \004\027\024-\022\017\001\036\004\027\024\020\024 \021\030\026\022\021\026\ \(\215\030\026\022\021\017\004\036\f\022\017\036)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026\006\017\017.)Tj /Span<>> BDC ( )Tj EMC (\210\002\024\030)Tj /Span<>> BDC ( )Tj EMC [(\035\017\021\036\030\026\021\031\030\t\).)23( )]TJ /T1_2 1 Tf -0.023 Tw 0 -1.2 TD (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_1 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (167\226180. https://doi.org/10.33878/2073-7556-2026-25-1-167-180)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0.023 Tw 18 0 0 18 114.6616 670.0774 Tm [(Diagnosis and tr)31(eatment of\022)-23.3(lipomas of\022)-23.3(th)11(e digestiv)12.1(e )]TJ 1.853 -1.167 Td [(tr)21(act \(Pr)21.1(actical r)31(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 624.5734 Tm [(Mikhail\022)-23.2(S.\022)-23.3(Bur)31(dy)10(uk)11.1(ov)]TJ 8.162 0 0 8.162 189.3404 629.2354 Tm [(1)69(,2,3)]TJ 0.023 Tw 14 0 0 14 207.9088 624.5734 Tm [(, Nair)21(a\022)-23.2(A)-31(.\022)-23.3(Hayr)21(apet)-19.9(y)21(an)]TJ 0 Tw 8.162 0 0 8.162 342.5848 629.2354 Tm (3)Tj 0.023 Tw 14 0 0 14 347.2208 624.5734 Tm [(, Ildar\022)-23.2(R.\022)-23.3(V)31(aliulin)]TJ 0 Tw 8.162 0 0 8.162 441.115 629.2354 Tm (4)Tj 14 0 0 14 445.7509 624.5734 Tm (, )Tj -26.777 -1.143 Td [(Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(Gv)10(o)15(z)21(de)11(v)]TJ 8.162 0 0 8.162 180.7592 613.2354 Tm (5)Tj 0.023 Tw 14 0 0 14 185.3951 608.5734 Tm [(, Grigor)-30.9(y\022)-23.3(A)-31(.\022)-23.3(K)41(or)20(ole)11(v)]TJ 0 Tw 8.162 0 0 8.162 301.4937 613.2354 Tm (6)Tj 0.023 Tw 14 0 0 14 306.1296 608.5734 Tm [(, Ox)11(ana\022)-23.2(V)61.9(.\022)-23.2(P)20(aklina)]TJ -0.127 Tc 0.127 Tw 8.162 0 0 8.162 412.3864 613.2354 Tm [(7,)-127(8)]TJ 0 Tc 0 Tw 14 0 0 14 423.2335 608.5734 Tm (, )Tj -25.169 -1.143 Td [(V)31(aleriia\022)-23.2(I.\022)-23.3(R)20(y)21(abtse)11(v)10(a)]TJ 8.162 0 0 8.162 185.8269 597.2354 Tm (9)Tj 0.023 Tw 14 0 0 14 190.4629 592.5734 Tm [(, Natalia\022)-23.2(V)62(.\022)-23.3(Ageykina)]TJ 0 Tw 8.162 0 0 8.162 312.679 597.2354 Tm (4)Tj 0.023 Tw 14 0 0 14 317.3149 592.5734 Tm [(, Ev)10(genia\022)-23.2(V)62(.\022)-23.3(Guse)11(v)10(a)]TJ 0 Tw 8.162 0 0 8.162 430.67 597.2354 Tm (4)Tj 0.023 Tw 14 0 0 14 435.3059 592.5734 Tm [(, Ilia\022)-23.2(I.\022)-23.3(Iv)10(anov)]TJ 0 Tw 8.162 0 0 8.162 512.7509 597.2354 Tm (4)Tj 14 0 0 14 517.3868 592.5734 Tm (, )Tj -31.894 -1.143 Td [(Irina\022)-23.2(Y)40(u.\022)-23.3(K)41(or)20(zh)11(e)11(v)10(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 173.9136 581.2354 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 185.2343 576.5734 Tm [(, Mak)11(sim\022)-23.2(M.\022)-23.3(Lokhmatov)]TJ 0 Tw 8.162 0 0 8.162 319.5468 581.2354 Tm [(6,1)75(0)]TJ 0.023 Tw 14 0 0 14 335.4543 576.5734 Tm [(, T)40(atiana\022)-23.2(V)62(.\022)-23.3(Nik)11(olaich)11(uk)]TJ 0 Tw 8.162 0 0 8.162 468.8704 581.2354 Tm (4)Tj 14 0 0 14 473.5063 576.5734 Tm (, )Tj -28.76 -1.143 Td [(Ily)21(a\022)-23.3(B.\022)-23.3(P)10(er)-10(f)-21(ile)11(v)]TJ -0.212 Tc 0.212 Tw 8.162 0 0 8.162 150.8547 565.2354 Tm (11)Tj 0 Tc 0.023 Tw 14 0 0 14 158.3964 560.5734 Tm [(, Ser)31(gey\022)-23.2(S.\022)-23.3(Pir)20(ogov)]TJ 0 Tw 8.162 0 0 8.162 266.2213 565.2354 Tm (9)Tj 0.023 Tw 14 0 0 14 270.8573 560.5734 Tm [(, V)31(asiliy\022)-23.2(V)62(.\022)-23.3(Sidorin)]TJ 0 Tw 8.162 0 0 8.162 373.3752 565.2354 Tm (4)Tj 0.023 Tw 14 0 0 14 378.0112 560.5734 Tm [(, Denis\022)-23.2(D.\022)-23.3(Star)31(ch)11(enk)11(ov)]TJ 0 Tw 8.162 0 0 8.162 504.5396 565.2354 Tm (4)Tj 5.83 0 0 5.83 70.8661 546.2342 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 542.9042 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education, Ministr)-31(y of\022)-23.3(Health of\022)-23.3(th)11(e Russian F)20(eder)21(ation )]TJ -0.331 -1.2 Td [(\(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69.1(, Building 1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 522.2342 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 518.9042 Tm [(F)20(eder)21(al Net)-19.9(w)11(ork of\022)-23.3(Clinics \232Eur)20(oonco)-41.9(\233 \(Dukh)11(ov)10(sk)11(oy Lane, 22B, Moscow)22(, 1)212(1)113(5)127(1)138(9)125(1)69(, Russia\);)]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 510.2342 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 506.9042 Tm [(Moscow Multidisciplinar)-30.8(y Clinical and Diagnostic Center named af)-30.9(ter S.P)94(.\022)-23.3(Botkin, Depar)-20(tment of\022)-23.3(Health of\022)-23.3(th)11(e )]TJ -0.331 -1.2 Td [(Cit)-20(y of\022)-23.2(Moscow \(2nd Botkinsky Pr)20(oe)21(z)21(d, 5, Moscow)22.1(, 1)125(2)23(5)35(2)35(8)34(4, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 486.2343 Tm (4)Tj 0.023 Tw 10 0 0 10 74.1775 482.9043 Tm [(Medsi Clinical Diagnostic Center \(CDC\) on Kr)21(asnay)21(a Pr)31(esny)21.1(a Str)31(eet \(Kr)21(asnay)21.1(a Pr)31(esny)21(a\022)-23.2(st., 1)112(6, Moscow)22.1(, )]TJ -0.331 -1.2 Td [(1)125(23)46(2)69(42, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 462.2343 Tm (5)Tj 0.023 Tw 10 0 0 10 74.1775 458.9043 Tm [(Dav)-21(y)10(dov)10(sky Cit)-19.9(y Clinical Hospital, Depar)-20(tment of\022)-23.3(Health of\022)-23.3(th)11(e Cit)-20(y of\022)-23.3(Moscow \(Y)50(au)21(z)10(skay)21(a\022)-23.2(st., 1)212(1/6, Moscow)22(, )]TJ -0.331 -1.2 Td [(1)75(09)35(2)69(40, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 438.2344 Tm (6)Tj 0.023 Tw 10 0 0 10 74.1775 434.9044 Tm [(National Medical Resear)31.1(ch Center for Childr)31(en\236)63.1(s Health, Ministr)-30.9(y of\022)-23.3(Health of\022)-23.2(th)11(e Russian F)19.9(eder)21.1(ation )]TJ -0.331 -1.2 Td [(\(Lomonosov)10.1(sky Pr)20(ospect, 2, bld.\022)-23.3(1)69(, Moscow)22(, 1)212(1)138(999)125.1(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 414.2344 Tm (7)Tj 0.023 Tw 10 0 0 10 74.1775 410.9044 Tm [(Moscow Clinical Resear)31.1(ch Center named A)-31(.S.\022)-23.3(Loginov)21.1(, Depar)-20(tment of\022)-23.3(Health of\022)-23.3(th)11(e Cit)-20(y of\022)-23.2(Moscow )]TJ -0.331 -1.2 Td [(\(Nov)10(ogir)31(ee)11(v)10(skay)21.1(a\022)-23.3(st., 1)69(, bld.\022)-23.2(1)69(, Moscow)22(, 1)212(1)212(1)212(1)125(23, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 390.2345 Tm (8)Tj 0.023 Tw 10 0 0 10 74.1775 386.9045 Tm [(National Medical Resear)31.1(ch Center of\022)-23.3(Sur)31(ger)-31(y named A)-31(.V)62(.\022)-23.3(Vishne)11(v)10(sky)31(, Ministr)-31(y of\022)-23.2(Health of\022)-23.3(th)11(e Russian )]TJ -0.331 -1.2 Td [(F)20(eder)21(ation \(Bolshay)21(a Serpukh)11.1(ov)10(skay)21(a\022)-23.3(st., 2)46(7)127(, Moscow)22(, 1)212(1)113(509)35(3, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 366.2346 Tm (9)Tj 0.023 Tw 10 0 0 10 74.1775 362.9046 Tm [(P)94(.A)-31(.\022)-23.3(Her)-19.9(tsen Moscow Oncology Resear)31.1(ch Institute\022)-23.2(\230 br)21(anch of\022)-23.2(th)11(e National Medical Resear)31.1(ch Radiological )]TJ -0.331 -1.2 Td [(Centr)31(e, Ministr)-30.9(y of\022)-23.3(Health of\022)-23.2(th)11(e Russian F)20(eder)21(ation \(2nd Botkinsky Pr)20(oe)21(z)21(d, 3, Moscow)22.1(, 1)125(2)23(5)35(2)35(8)34(4, Russia\))]TJ 0 Tw ( )Tj -0.075 Tc 0.075 Tw 5.83 0 0 5.83 70.8661 342.2346 Tm (10)Tj 0 Tc 0.023 Tw 10 0 0 10 77.0517 338.9046 Tm [(Sech)11(enov Fir)20.1(st Moscow State Medical Univ)12.1(er)20(sit)-20(y \(Sech)11(enov Univ)12(er)20(sit)-19.9(y\), Ministr)-31(y of\022)-23.2(Health of\022)-23.2(th)11(e Russian )]TJ -0.619 -1.2 Td [(F)20(eder)21(ation \(T)20(r)10(ubetskay)21(a\022)-23.2(st., 8, Building 2, Moscow)22.1(, 1)212(1)138(90)25(48, Russia\))]TJ 0 Tw ( )Tj -0.212 Tc 0.212 Tw 5.83 0 0 5.83 70.8661 318.2347 Tm (11)Tj 0 Tc 0.023 Tw 10 0 0 10 76.253 314.9047 Tm [(Br)21(anch Oncology Center \0231 of\022)-23.3(th)11(e Moscow Cit)-20(y Hospital named S.S.\022)-23.3(Y)40(udina, Depar)-19.9(tment of\022)-23.2(Health of\022)-23.3(th)11(e Cit)-20(y )]TJ -0.539 -1.2 Td [(of\022)-23.3(Moscow \(Z)21(agor)20(odnoy)10(e Sh)11(osse, 1)112(8A)-31(, Building 7)127(, Moscow)22(, 1)212(1)138(7)127(1)113(5)35(2, Russia\))]TJ /T1_2 1 Tf 0.006 Tc 0.136 Tw 9 0 0 9 119.0551 284.4008 Tm [(Lipoma is a common benign subepithelial neoplas)33(m of mesench)12(ymal or)-37(igin that dev)13(elops slow)10(ly from adipose)6( )]TJ 0.106 Tw 0 -1.111 TD [(tissue )0.6(in )0.6(the )0.5(g)12(astrointestinal )0.5(tract. )0.6(Most )0.5(lipomas )0.6(occur )0.5(in )0.6(the )0.5(colon, )0.5(accounting )0.5(for )0.5(60-75% )0.6(of )0.5(cases, )0.6(with )0.5(less)6( )]TJ 0.076 Tw T* [(freq)14(uent occur)-16(rences in the s)33(mall intestine, esophagus, and stomach. Diagnosis is typically made thro\ ugh endo)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.094 Tw T* [(scopic e)-15(x)10(amination, while endosonog)14(raph)12(y can p)46(rovide more specif)-43(ic infor)-14(mation. In endosonog)14(raphic imaging,)6( )]TJ 0.018 Tw T* [(lipomas appear as homog)12(eneous, h)12(yperechoic masses or)-37(iginating from the submucosa \(third layer\). If the lipoma)6.1( )]TJ 0.046 Tw 0 -1.111 TD [(g)14(rows or becomes malignant, additional tests such as forceps biopsy)42(, step biopsy)42(, or f)-43(ine needle aspiration under)6( )]TJ -0.027 Tw 0 -1.111 TD [(endoscopic ultrasound guid)26(ance can be per)-34(for)-14(med for mor)-18(phological v)13(er)-37(if)-43(ication. T)56(reatment is recommended if the)6( )]TJ -0.016 Tw T* [(lipoma causes sym)16(p)13(toms lik)17(e pain, obstruction, or bleeding, or if it e)-15(xceeds 2 centimeters in size. F)12(or asym)16(p)13(tomatic)6( )]TJ 0.025 Tw T* [(lipomas, obser)-42(v)16(ation p)46(ro)13(tocols may in)11(v)13(olv)13(e regular endoscopic assess)33(ments based on size and location to monitor)6( )]TJ 0.023 Tw T* [(for an)11(y chang)12(es.)6.1( )]TJ /T1_0 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 179.1315 Tm [(KEYW)22(ORDS:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( lipoma, dig)12(estiv)13(e tract, upper endoscop)12.1(y)42(, endosonog)14.1(raph)12(y)42(, mor)-18(phological diagnosis)]TJ /T1_0 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_0 1 Tf 0.031 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.3(O)-4.6(R)8.7( C)-17.4(I)-15.6(T)45.5(A)37.5(T)-24.4(I)-1.3(ON:)]TJ /T1_1 1 Tf 0.017 Tc -0.035 Tw 6.323 0 Td [( B)-6.6(u)-7.5(r)-18.1(d)-20.5(y)-21.4(u)-9.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.)-26.9(S)-9.5(.)-23.5(, H)-4.3(a)-14.9(y)-32.2(r)-30.7(a)-8.8(p)-24.7(e)-22.2(t)-50.9(y)-24.2(a)-7.6(n)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.8(.)-23.9(A)-22.9(.)-23.5(, V)3.8(a)-11.3(l)-16.7(i)-3.5(u)-8.3(l)-16.7(i)-3.1(n)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.R)-21.3(.)-23.5(, G)-6.9(v)-15.4(o)-7.9(z)-15.3(d)-15.3(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)-23.9(A)-22.9(.)-23.5(, K)-11.1(o)-11.8(r)-15.8(o)-15.6(l)-23.6(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(G)-11.5(.)-23.9(A)-22.9(.)-23.5(, P)-10.3(a)-11.1(k)-17.3(l)-16.7(i)-3.1(n)-7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)40.7(V)39.7(.)-23.5(, R)-30.3(y)-24.2(a)-18.2(b)-22.7(t)-48.9(s)-22.9(e)-15.7(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-9.7(I)-10.3(.)-23.4(, A)-8.4(g)-14.4(e)-20(y)-21.9(k)-41.1(i)-3.1(n)-7.8(a)]TJ /Span<>> BDC ( )Tj EMC [(N)-2.7(.)40.6(V)39.7(.)-23.5(,)17( )]TJ 0.023 Tc 0.021 Tw -6.328 -1.2 Td [(G)-11.2(u)-21.9(s)-22.9(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.6(.)40.6(V)39.7(.)-23.5(, I)11.7(v)-28.4(a)-7.6(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)-9.8(I)-10.3(.)-23.5(, K)-11.1(o)-11.9(r)-42.9(z)-12.6(h)-15(e)-15.9(v)-28.3(a I)-10.3(.)51.6(Y)12.6(u)-9(.)-23.5(, L)-24.8(o)-15.1(k)-16.8(h)-6.2(m)-8.3(a)-18.2(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7(.)-7.3(M)-7.1(.)-23.5(, N)-13.5(i)-6.6(k)-3.7(o)-15.6(l)-37.8(a)-14.9(i)-5(c)-10.2(h)-7(u)-9.6(k)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)40.6(V)39.7(.)-23.5(, P)-4.2(e)-12.1(r)-56(f)-63(i)-7(l)-23.7(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.B)3.3(.)-23.5(, P)-34(i)-6(r)-15.8(o)-18.6(g)-10.2(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)-26.9(S)-9.6(.)-23.5(, S)-1.4(i)-8.8(d)-11.1(o)-11.8(r)-56.4(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)40.6(V)39.7(.)-23.5(, S)-3.2(t)-36.8(a)-10.2(r)-11.7(c)-10.2(h)-15.1(e)-11.5(n)-8.8(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)1.4(D)16.4(.)23.1( )]TJ 0.015 Tc -0.035 Tw 0 -1.2 TD [(D)-30.2(i)-5(a)-10.6(g)-8.7(n)-11.8(o)-15.7(s)-26(i)-7.3(s a)-7.5(n)-14.3(d t)-30.6(r)-19(e)-12.9(a)-18.1(t)-25.9(m)-16.5(e)-11.4(n)-17.2(t o)-12(f)]TJ /Span<>> BDC ( )Tj EMC [(l)-16.6(i)-2.5(p)-22.1(o)-9.1(m)-8.2(a)-26.5(s o)-12(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26(h)-14.9(e d)-15.7(i)-6.6(g)-14.3(e)-22.7(s)-29.2(t)-46.1(i)-14.3(v)-18.6(e t)-30.7(r)-30.7(a)-11(c)-41.3(t \()4.3(P)-18.5(r)-30.7(a)-10.9(c)-41.4(t)-46.1(i)-4.9(c)-21.4(a)-11.3(l r)-18.9(e)-19(c)-6.4(o)-9.1(m)-6.1(m)-16.4(e)-11.4(n)-14.4(d)-9.2(a)-18.1(t)-46.1(i)-6.6(o)-9.1(n)-11.1(s)-15.4(. R)-6.6(e)-15.7(v)-51.6(i)-10.9(e)-12.4(w)19.7(\))10.5(. )]TJ /T1_2 1 Tf 0.025 Tc -0.025 Tw [(K)14(ol)3.7(op)2.5(r)3.2(o)3.6(k)-19.1(t)2.3(ol)3.7(o)-3.1(g)-13.1(i)6.8(a)5.9(.)]TJ /T1_1 1 Tf 0 Tc -0.02 Tw 47.732 0 Td [( 2)-23.8(0)-18.7(2)-10.7(6)5(;)-5(2)-16.3(5)-14(\()22.8(1)29.4(\):)6.1(1)-2.3(6)-13.1(7)20.8(\226)35.9(1)-17.3(8)-38.3(0)-8.3(. )]TJ 0.023 Tc 0.024 Tw -47.732 -1.2 Td [(\()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.8(2)-1.4(5)-23.6(-)55.2(1)26.8(-)55.2(1)12.6(6)1.8(7)36.2(-)55.1(1)-2.5(8)-23.4(0)]TJ /T1_0 1 Tf 0.01 Tc 0.05 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.6(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_2 1 Tf 0 Tc 0.055 Tw 10.64 0 Td [( )0.5(\206\t\240\006\027\021\020 )0.6(\211\020\f\027\032\022\t )0.5(\002\b\031\032\027\021\025\020, )0.6(\215\001\002\217\002 )0.6(\022\026. )0.5(\004.\003.)]TJ /Span<>> BDC ( )Tj EMC 18.895 0 Td (\216\027\032\006\027\025\020)Tj /Span<>> BDC ( )Tj EMC 3.601 0 Td [(\227 )0.5(\203\022\f\022\020\f )0.6(\214\216\221\210 )0.5(\253\001\215\002\037 )0.5(\032\020\030\022\031\f\031\b\022\022\273 )0.6(\215\022\025\016\030\032\020\021\020 )0.6(\206\031\024\024\022\022, )]TJ 0.023 Tw -33.141 -1.2 Td (2-\235 \221\031\023\n\022\025\024\n\022\235 \033\032\031\027\016\030, \030\ .)Tj /Span<>> BDC ( )Tj EMC (3, \215\031\024\n\021\020, 125284, \206\031\024\024\022\t; e-mail: valer\ yappv@gmail.com)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 292.9053 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_0 1 Tf 0 Tw 9 0 0 9 73.5728 283.978 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ -46.27 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8026 56.0378 Tm (168)Tj ET endstream endobj 295 0 obj [316 0 R] endobj 296 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022\020\004\225\004\t\n\004 \020\n\224\025\024 \226\004\020\ \002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-10(\026)11(\017 )]TJ 0 -1 TD [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022\005\004\r)10(\025\024\004\t\202\017\n\n.\022\036\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 40.305 1 Td [(Diagnosis and tr)31.1(eatment of\022lipomas of\022th)11(e digestiv)12(e )]TJ 3.612 -1 Td [(tr)21(act \(Pr)21(actical r)31.1(ecommendations. Re)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-167-180)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 150.1359 695.3259 Tm [(\201\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022)-23.3(\020\004\225\004\t\n\004 \020\n\224\025\024 )]TJ 0.097 -1.105 Td [(\226\004\020\002\202\025\225\t\025-\r\n\204\004\225\t\025\013)10.1(\025 \026\005\017\r)-9.9(\026)10.9(\017 )]TJ 0 Tw -4.434 -1.105 Td [(\(\034\005\017\r)-10(\026\n\225\004\016\r\n\004\022)-23.2(\005\004\r)10(\025\024\004\t\202\017\n\n.\022)-23.2(\036\255\212\025\005\022)-23.3(\020\n\026)11(\004\005\017\026)-19.9(\002\005\217\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\006\002\005\202\206\r)10(\025\b\022)-23.2(\235.\001.)]TJ 8.162 0 0 8.162 131.5627 633.484 Tm [(1)69(,2,3)]TJ 0.023 Tw 14 0 0 14 150.131 628.822 Tm [(, \f\221\005\017\224\004\026\213\t\022)-23.2(\007.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 250.1397 633.484 Tm (3)Tj 0.023 Tw 14 0 0 14 254.7757 628.822 Tm [(, \021\017\020\n\002\020\n\t\022)-23.3(\030.\033)124(.)]TJ 0 Tw 8.162 0 0 8.162 344.3265 633.484 Tm (4)Tj 0.023 Tw 14 0 0 14 348.9624 628.822 Tm [(, \031)68(\b\025)21(\212\202\004\b\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 431.1631 633.484 Tm (5)Tj 14 0 0 14 435.799 628.822 Tm (, )Tj -28.091 -1.143 Td [(\037)31(\025\005\025\020\004\b\022)-23.3(\031)72(.\f)-30.9(.)]TJ 8.162 0 0 8.162 117.311 617.484 Tm (6)Tj 0.023 Tw 14 0 0 14 121.947 612.822 Tm [(, \034\017\r)-10(\020\n\t\017\022)-23.2(\036.\021.)]TJ -0.127 Tc 0.127 Tw 8.162 0 0 8.162 209.9857 617.484 Tm [(7,)-127(8)]TJ 0 Tc 0.023 Tw 14 0 0 14 220.8329 612.822 Tm [(, \033\213\255\004\b\017\022)-23.2(\021.\030.)]TJ 0 Tw 8.162 0 0 8.162 304.252 617.484 Tm (9)Tj 0.023 Tw 14 0 0 14 308.888 612.822 Tm [(, \f\013)10(\004\221\r\n\t\017\022)-23.2(\007.\021.)]TJ 0 Tw 8.162 0 0 8.162 399.2507 617.484 Tm (4)Tj 0.023 Tw 14 0 0 14 403.8867 612.822 Tm [(, \031)70(\002\016\004\b\017\022)-23.2(\240.\021.)]TJ 0 Tw 8.162 0 0 8.162 474.958 617.484 Tm (4)Tj 14 0 0 14 479.594 612.822 Tm (, )Tj -31.22 -1.143 Td [(\030\b\017\t\025\b\022)-23.2(\030.\030.)]TJ 8.162 0 0 8.162 117.1987 601.484 Tm (4)Tj 0.023 Tw 14 0 0 14 121.8346 596.822 Tm [(, \037)31(\025\005\226\004\b\017\022)-23.2(\030.\207.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 216.2161 601.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 227.5367 596.822 Tm [(, \035\025\220\024\017\026)11.1(\025\b\022)-23.3(\235.\235.)]TJ 0 Tw 8.162 0 0 8.162 327.6016 601.484 Tm [(6,1)75(0)]TJ 0.023 Tw 14 0 0 14 343.5091 596.822 Tm [(, \007\n\r)10(\025\020\017\221\225\002\r\022)-23.2(\032.\021.)]TJ 0 Tw 8.162 0 0 8.162 445.6598 601.484 Tm (4)Tj 14 0 0 14 450.2957 596.822 Tm (, )Tj -29.127 -1.143 Td [(\034\004\005\216\n\020\200\004\b\022)-23.2(\030.\006.)]TJ -0.212 Tc 0.212 Tw 8.162 0 0 8.162 135.3985 585.484 Tm (11)Tj 0 Tc 0.023 Tw 14 0 0 14 142.9401 580.822 Tm [(, \034\n\005\025\013)10(\025\b\022)-23.2(\001.\001.)]TJ 0 Tw 8.162 0 0 8.162 228.1514 585.484 Tm (9)Tj 0.023 Tw 14 0 0 14 232.7873 580.822 Tm [(, \001\n\202\025\005\n\t\022)-23.2(\021.\021.)]TJ 0 Tw 8.162 0 0 8.162 317.7463 585.484 Tm (4)Tj 0.023 Tw 14 0 0 14 322.3823 580.822 Tm [(, \001\026)11(\017\005\225\004\t\r)10.1(\025\b\022)-23.3(\201.\201.)]TJ 0 Tw 8.162 0 0 8.162 427.3192 585.484 Tm (4)Tj 5.83 0 0 5.83 42.5197 566.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 563.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \253\033\025\016\016\n\221\016\r\017\213 \024\004\202\n\ \n\t\016\r\017\213 \017\r\017\202\004\024\n\213 \t\004\224\005\004\005\217\ \b\t\025\013)10(\025 \224\005\025\216\004\016\016\n\025\t\017\020\200\t\025\013)10(\025 \025\255\005\017\212\025\b\017\t\n\213\273 )]TJ -0.331 -1.2 Td [(\235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020.\022)-23.3(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.3(\235\025\016\r\b\017,1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 542.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 539.1527 Tm [(\210\004\202\004\005\017\020\200\t\017\213 \016\004\026\200 \r)-10(\020\n\t\n\r \253\240\b\005\025\025\t\r)10(\025\273 \(\201\002)21(\220\025\b\016\r)10(\025\221 \224\004\005)-30.9(., \202.\022)-23.3(22\255, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)113(5)127(1)138(9)125(1)69(, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 530.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 527.1528 Tm [(\031\006)42(\227)31(\203 \253\235\025\016\r)10.1(\025\b\016\r\n\221 \024\t\025\013)10(\025\224\005\025\216\n\020\200\t\217\221 \r)-10(\020\n\t\n\r)10.1(\025-)-73(\202\n\017\013\t\025\016)-10(\026\n\225\004\016\r\n\221 \004\t\026\005 \n\024.\022)-23.3(\001.\034.\022)-23.3(\006\025\026\r\n\t\017 \201)21(\203\235\273 \(2-\221 )]TJ -0.331 -1.2 Td [(\006\025\026\r\n\t\016\r\n\221 \224\005\025\004\212\202, \202.\022)-23.3(5, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(2)23(5)35(2)35(8)34(4, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 506.4828 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 503.1528 Tm [(\037\201\003 \253\235\240\201\001\030 \t\017\022)-23.3(\037)20(\005\017\016\t\025\221 \034\005\004\016\t\004\273, \f\036 \253\235\240\201\ \001\030-2\273 \(\002\020.\022)-23.3(\037)20(\005\017\016\t\017\213 \034\005\004\016\t\213, \202.\022)-23.3(1)112(6, \013)62(.\022)-23.2(\235\025\016\r\b\017,1)125(23)46(2)69(42, )]TJ 0 Tw -0.331 -1.2 Td (\033\025\016\016\n\213\))Tj ( )Tj 5.83 0 0 5.83 42.5197 482.4829 Tm (5)Tj 0.023 Tw 10 0 0 10 45.8311 479.1529 Tm [(\031\006)42(\227)31(\203 \253\031\037\006 \n\024.\022)-23.3(\030.\021.\022)-23.3(\201\017\b\217\202\025\b\016\r)10.1(\025\013)10(\025 \201)21(\203\235\273 \(\002\020.\022)-23.3(\027\002)31(\212\016\r\017\213, \202.\022)-23.2(1)212(1/6, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)75(09)35(2)69(40, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 470.4829 Tm (6)Tj 0.023 Tw 10 0 0 10 45.8311 467.1529 Tm [(\210\031)83(\f)41(\227 \253\007\017\n\025\t\017\020\200\t\217\221 \024\004\202\n\n\t\016\ \r\n\221 \n\016\016)-10(\020\004\202\025\b\017\026)11.1(\004\020\200\016\r\n\221 \004\t\026\005 \212\202\025\005\025\b\200\213 \ \202\004\026)11(\004\221\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n )]TJ -0.331 -1.2 Td [(\(\035\025\024\025\t\025\016\025\b\016\r\n\221 \224\005-)-42(\026, \202.\022)-23.3(2, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)138(999)125(1)69(, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 446.483 Tm (7)Tj 0.023 Tw 10 0 0 10 45.8311 443.153 Tm [(\031\006)42(\227)31(\203 \253\235\025\016\r)10.1(\025\b\016\r\n\221 \r)-10(\020\n\t\n\225\004\016\r\n\221 \t\017\002\225\t\217\221 \004\t\026\005 \ \n\024.\022)-23.3(\f)-30.9(.\001.\022)-23.3(\035\025\013\n\t\025\b\017\273 \201)21(\203\235 \(\002\020.\022)-23.3(\007\025\b\025\013\n\005\004\004\b\016\r\017\213, \202.\022)-23.2(1)68.9(, )]TJ -0.331 -1.2 Td [(\r)10(\025\005\224.\022)-23.3(1)69(, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)212(1)212(1)125(23, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 422.483 Tm (8)Tj 0.023 Tw 10 0 0 10 45.8311 419.153 Tm [(\210\031\006)42(\227 \253\007\017\n\025\t\017\020\200\t\217\221 \024\004\202\n\n\t\016\ \r\n\221 \n\016\016)-10(\020\004\202\025\b\017\026)11.1(\004\020\200\016\r\n\221 \004\t\026\005 \220\n\005\002\005\013\n\n \n\024\ .\022)-23.3(\f)-31(.\021.\022)-23.3(\021\n\204\t\004\b\016\r)10(\025\013)10(\025\273 \235\n\t\212\202\005\017\b\017 )]TJ -0.331 -1.2 Td [(\033\025\016\016\n\n \(\002\020.\022)-23.2(\006\025\020\200\204\017\213 \001\004\005\224\002)21(\220\025\b\016\r\017\213, \202.\022)-23.3(2)46(7)127(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)212(1)113(509)35(3, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 398.4831 Tm (9)Tj 0.023 Tw 10 0 0 10 45.8311 395.1531 Tm [(\235\025\016\r)10(\025\b\016\r\n\221 \t\017\002\225\t\025-\n\016\016)-10(\020\004\202\025\b\017\026)11.1(\004\020\200\016\r\n\221 \025\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \n\t\016)-9.9(\026\n\026)-20(\002)-20(\026 \n\024.\022)-23.3(\034.\f)-31(.\022)-23.3(\031)70(\004\005\004\t\017\022)-23.2(\230 \216\n\020\n\017\020 \210\031\006)42(\227 )]TJ -0.331 -1.2 Td [(\253\007\235\030\003 \005\017\202\n\025\020\025\013\n\n\273 \235\n\t\212\ \202\005\017\b\017 \033\025\016\016\n\n \(2-\221 \006\025\026\r\n\t\016\r\ \n\221 \224\005\025\004\212\202, \202.\022)-23.3(3, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125.1(2)22.9(5)35(2)35(8)34(4, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj -0.075 Tc 0.075 Tw 5.83 0 0 5.83 42.5197 374.4832 Tm (10)Tj 0 Tc 0.023 Tw 10 0 0 10 48.7052 371.1532 Tm [(\210\031)83(\f\036)20(\227 \021\036 \253\034\004\005\b\217\221 \235\025\016\r)10(\025\b\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-10(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026 \n\024\004\t\n \030.\235.\022)-23.3(\001\004\225\004\t\025\b\017\273 )]TJ -0.619 -1.2 Td [(\235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\001\004\225\004\t\ \025\b\016\r\n\221 \227)42(\t\n\b\004\005\016\n\026)11(\004\026\) \(\002\020.\022)-23.3(\032)30(\005\002\255\004\r\017\213, \202.\022)-23.3(8, \016)-10(\026\005)-31(.\022)-23.2(2, \013)62(.\022)-23.3(\235\025\016\r\b\017, 1)212(1)138(90)25(48, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj -0.212 Tc 0.212 Tw 5.83 0 0 5.83 42.5197 350.4832 Tm (11)Tj 0 Tc 0.023 Tw 10 0 0 10 47.9065 347.1532 Tm [(\210\n\020\n\017\020 \253\036\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \004\t\026\005 \0231 \031)80(\025\005\025\202\016\r)10(\025\221 \r)-10(\020\n\t\n\225\004\016\r)10(\025\221 \255\025\020\200\t\n\217 \n\024\004\t\n \001.\001.\022)-23.3(\207\202\n\t\017 \201)21(\203\235\273 )]TJ -0.539 -1.2 Td [(\(\203\017\013)10(\025\005\025\202\t\025\004 \204., \202.\022)-23.3(1)112(8\f)-52(, \016)-10(\026\005)-31(.\022)-23.3(7)127(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)212(1)138(7)127(1)113(5)35(2, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf -0.034 Tw 9 0 0 9 90.7087 316.6493 Tm (\037\036\035\034: \033\032\031\020\025\020\f\022\016\022\032\031\021\020\ \023\017 \204\025\030\031\024\n\031\033\022\007\027\024\n\022\027, \204\025\ \030\031\024\031\025\031\b\032\020\203\022\007\027\024\n\022\027 \033\032\ \022\016\025\020\n\022 \f\022\033\031\026 \031\032\b\020\025\031\021 \255\ \027\f\r\030\031\007\025\031-\n\022\213\027\007)Tj 0 Tw (-)Tj 0.002 Tw 0 -1.111 TD (\025\031\b\031 \023\032\020\n\023\020, \032\020\024\024\026\031\023\032\027\ \023\017 \022\200 \030\022\203\203\027\032\027\025\006\022\020\f\017\025\ \031-\030\022\020\b\025\031\024\023\022\007\027\024\n\022\027 \033\032\022\ \016\025\020\n\022, \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027, \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\020\025\022\022 \030\020\025\025\013\200 )Tj 0.212 Tw T* [(\026\022\032\031\021\031\235 )0.5(\f\022\023\027\032\020\023\r\032\013, \032\020\016\032\020\240\031\023\020\ \023\017 )0.5(\020\n\023\r\020\f\017\025\013\235 )0.5(\020\f\b\031\032\022\023\026 )0.5(\021\027\030\027\025\022\t \033\020\006\022\027\025\023\031\021 \024)]TJ /Span<>> BDC ( )Tj EMC 35.796 0 Td (\f\022\033\031\026\020\026\022 \255\027\f\r\030\031\007\025\031-)Tj 0.023 Tw -35.796 -1.111 Td (\n\022\213\027\007\025\031\b\031 \023\032\020\n\023\020.)Tj 0.261 Tw T* [(\217\205\001\217\211\001\201\036 )0.6(\004\217\035\217\234\036\001\002\226: )0.6(\f\022\033\031\026\013 )0.7(\t\021\f\t\005\023\024\t )0.6(\025\020\022\240\031\f\027\027 )0.7(\032\020\024\033\032\031\024\023\032\020\025\233\025\025\013\026\022 )0.5(\030\031\240\032\031\n\020\007\027\024\023\021\027\025\025\013\026\022 )0.6(\022\025\023\032\020)]TJ 0 Tw (-)Tj 0.177 Tw 0 -1.111 TD (\026\r\032\020\f\017\025\013\026\022 \025\031\021\031\031\240\032\020\016\ \031\021\020\025\022\t\026\022 \026\027\016\027\025\200\022\026\020\f\017\ \025\031\b\031 \033\032\031\022\024\200\031\255\030\027\025\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\255\027\f\r\030\031\007\025\031-\n\022\213\027\007\025\031\026 \023\032\ \020\n\023\027 \(\234\202\), )Tj 0.24 Tw 0 -1.111 TD (\026\027\030\f\027\025\025\031 \032\020\016\021\022\021\020\005\212\022\026\ \022\024\t \022\016)Tj /Span<>> BDC ( )Tj EMC (\255\022\032\031\021\031\235 \023\n\020\025\022. \217\024\025\031\021\025\ \020\t \007\020\024\023\017 \f\022\033\031\026 \f\031\n\020\f\022\016\r\027\ \023\024\t \021)Tj /Span<>> BDC ( )Tj EMC (\023\031\f\024\023\031\235 \n\022\213\n\027 )Tj 0.066 Tw T* (\(60\23175%\), \032\027\255\027)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\023\031\025\n\031\235 \n\022\213\n\027, \033\022\212\027\021\031\030\027\ \022)Tj /Span<>> BDC ( )Tj EMC (\255\027\f\r\030\n\027. \220\022\020\b\025\031\024\023\022\n\020 \031\024\ \025\031\021\013\021\020\027\023\024\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\204\025\030\031\024\n\031\033\022\007\027\024\n\031\026 )Tj 0.117 Tw T* (\022\024\024\f\027\030\031\021\020\025\022\022, \020)Tj /Span<>> BDC ( )Tj EMC (\023\031\007\025\r\005 \200\020\032\020\n\023\027\032\022\024\023\022\n\r\ \031\033\r\200\031\f\022 \033\031\016\021\031\f\t\027\023 \r\024\023\020\ \025\031\021\022\023\017 \204\025\030\031\024\031\025\031\b\032\020\203\022\ \t \(\230\210\205\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\230\210\205 )Tj -0.03 Tw T* (\f\022\033\031\026\013 \021\022\016\r\020\f\022\016\022\032\r\005\023\024\ \t \n\020\n \b\031\026\031\b\027\025\025\013\027 \b\022\033\027\032\204\200\ \031\b\027\025\025\013\027 \031\240\032\020\016\031\021\020\025\022\t, \022\ \024\200\031\030\t\212\022\027 \022\016)Tj /Span<>> BDC ( )Tj EMC (\033\031\030\024\f\022\016\022\024\023\031\b\031 \024\f\031\t \(3 )Tj 0.072 Tw T* [(\204\200\031\024\f\031\235\). )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC [(\024\f\r\007\020\027 \r\021\027\f\022\007\027\025\022\t )0.5(\032\020\016\026\027\032\031\021 )0.5(\022\f\022 \016\f\031\n\020\007\027\024\023\021\027\025\025\031\b\031 )0.5(\033\027\032\027\032\031\255\030\027\025\022\t \026\031\b\r\023 \033\032\ \022\026\027\025\t\023\017\024\t \026\027\023\031\030\013 )]TJ 0.176 Tw 0 -1.111 TD (\026\031\032\203\031\f\031\b\022\007\027\024\n\031\235 \021\027\032\022\203\ \022\n\020\006\022\022, \023\020\n\022\027 \n\020\n \212\022\033\006\027\ \021\020\t \240\022\031\033\024\022\t, \024\023\r\033\027\025\007\020\023\ \020\t \240\022\031\033\024\022\t \022\f\022 \023\031\025\n\031\022\b\031\ \f\017\025\020\t )Tj 0.222 Tw 0 -1.111 TD (\240\022\031\033\024\022\t \033\031\030 \n\031\025\023\032\031\f\027\026\ \230\210\205 \(\230\210\205-\002\004\). \210\030\020\f\027\025\022\027\ \033\031\n\020\016\020\025\031 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\022 \024\022\026\033\023\031\026\031\021 \(\240\031\ \f\017, \031\240\024\023\032\r\n\006\022\t, )Tj 0.147 Tw T* (\n\032\031\021\031\023\027\007\027\025\022\027\) \022\f\022 \033\032\022\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\016\026\027\032\020\200 \240\031\f\027\027 2 \024\026. \220\f\t\ \240\027\024\024\022\026\033\023\031\026\025\013\200 \031\240\032\020\016\ \031\021\020\025\022\235 \032\020\016\032\020\240\031\023\020\025\013 \033\ \032\031\023\031\n\031\f\013 )Tj 0.023 Tw T* (\025\020\240\f\005\030\027\025\022\t \024)Tj /Span<>> BDC ( )Tj EMC (\032\027\b\r\f\t\032\025\031\235 \204\025\030\031\024\n\031\033\022\007\027\ \024\n\031\235 \031\006\027\025\n\031\235 \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \032\020\016\026\027\ \032\031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\023\031\033\031\f\031\255\027\025\022\t.)Tj -0.002 Tc 0.019 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.5(\f\022\033\031\026\013 )0.5(\t\021\f\t\005\023\024\t )0.5(\031\030\025\022\026\022 )0.6(\022\016)]TJ /Span<>> BDC ( )Tj EMC 18.324 0 Td [(\025\020\022\240\031\f\027\027 )0.5(\007\020\024\023\031 )0.5(\021\024\023\032\027\007\020\005\212\022\200\024\t )0.6(\031\240\032\020\016\031\021\020\025\022\235 )0.5(\255\027\f\r\030\031\007\025\031-\n\022\213\027\007)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc -0.009 Tw -18.324 -1.111 Td (\025\031\b\031 \023\032\020\n\023\020. \001\027\024\026\031\023\032\t \025\ \020)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\027 \033\020\023\031\b\025\031\026\031\025\022\007\ \025\013\200 \033\032\022\016\025\020\n\031\021, \033\031\016\021\031\f\t\ \005\212\022\200 \n\031\032\032\027\n\023\025\031 \033\031\024\023\020\021\ \022\023\017 \030\022\020\b)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.002 Tw T* [(\025\031\016, )0.5(\033\032\022\026\027\025\027\025\022\027 \030\031\033\031\f\025\022\023\027\ \f\017\025\013\200 )0.5(\026\027\023\031\030\031\021 \031\240\024\f\027\030\031\021\020\025\022\t\ , )0.5(\023\020\n\022\200 )0.5(\n\020\n \204\025\030\031\024\031\025\031\b\032\020\203\022\t, \020)]TJ /Span<>> BDC ( )Tj EMC 36.413 0 Td [(\021 \025\027\n\031\023\031\032\013\200 )0.5(\024\f\r\007\020\t\200)-2( )]TJ -0.032 Tw -36.413 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\240\022\031\033\024\022\t \024)Tj /Span<>> BDC ( )Tj EMC (\006\027\f\017\005 \026\031\032\203\031\f\031\b\022\007\027\024\n\031\235\ \021\027\032\022\203\022\n\020\006\022\022, \030\031\f\255\025\013 \032\ \020\024\024\026\020\023\032\022\021\020\023\017\024\t \021)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\027 \024\023\020\025\030\020\032\023\025\031\b\ \031 \030\022\020\b)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.023 Tw T* (\025\031\024\023\022\007\027\024\n\031\b\031 \020\f\b\031\032\022\023\026\ \020, \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\020\025\022\022 \n\031\023\031\032\013\200 \021\013\ \024\023\032\020\022\021\020\027\023\024\t \030\020\f\017\025\027\235\213\ \020\t \023\020\n\023\022\n\020 \021\027\030\027\025\022\t \033\020\006\022\ \027\025\023\020.)Tj /T1_2 1 Tf 0.01 Tc 0.116 Tw 8 0 0 8 42.5596 111.3801 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.122 Tw 8.591 0 Td [( )0.5(\f\022\033\031\026\020, )0.5(\255\027\f\r\030\031\007\025\031-\n\022\213\027\007\025\013\235 )0.6(\023\032\020\n\023, )0.5(\204\025\030\031\024\n\031\033\022\007\027\024\n\020\t )0.5(\030\022\020\b\025\031\024\023\022\n\020, )0.5(\204\025\030\031\024\031\025\031\b\032\020\203\022\t, )0.6(\026\031\032\203\031\f\031\b\022\007\027\024\n\020\t )0.6(\021\027\032\022\203\022)]TJ 0 Tw (-)Tj -8.596 -1.2 Td (\n\020\006\022\t)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 325.1538 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 316.2265 Tm (\021\033\r\035\f\033)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5895 837.3533 Tm [(\200\n)43(\037\212\r\006\223\207\017\212\006\207)5( \n\207\212)21.1(\004\213\207\t\216)-21(\037\222\006\006)]TJ /T1_0 1 Tf 0 -1.605 TD [(PRA)15(CTIC)10(AL)5( REC)21(O)20(MMEND)20(A)30(TIONS)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\034\033)30(\f\037\032\030\215\240\001\037\030\240 \033\240\037)31(\036)30(\235\240\007\201)-11(\f\003\030\030)]TJ 46.27 0 Td [(PRA)15(CTIC)10(AL REC)21(O)20(MMEND)20(A)30(TIONS)]TJ /T1_4 1 Tf 25 0 0 25 505.5644 56.0378 Tm (167)Tj ET q 0 g /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 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A)15.1(dipose-der)-37(i)-16(ved stem cells: )]TJ 0.012 Tc 0.433 Tw -1.796 -1.25 Td [(isol)-15.7(a)15.3(t)-31.7(ion, char)-32.7(a)-16.7(c)-15.7(ter)-36.7(iza)15.2(t)-31.7(ion, and dif)-55.7(fer)-23.7(ent)-31.7(ia)15.2(t)-31.7(ion po)17.3(tent)-31.7(ial. )]TJ /T1_1 1 Tf -0.012 Tw [(Cell)12( )]TJ 0 Tc 0 Tw T* [(T)56(ransplant.)]TJ /T1_0 1 Tf 0.023 Tw [( 2013;22\(4\):701\226709. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3727/096368912X655127)Tj 0 0 0 1 k /GS1 gs 0.121 Tw T* (72.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Johal)Tj /Span<>> BDC ( )Tj EMC [(K)-25(S, L)35(ees)]TJ /Span<>> BDC ( )Tj EMC [(VC, R)13(eid)]TJ /Span<>> BDC ( )Tj EMC [(AJ. A)15(dipose-der)-36.9(i)-16(ved stem cells: selec)-16(t)]TJ 0 Tw (-)Tj 0.012 Tc 0.446 Tw -1.796 -1.25 Td [(ing )0.5(for )0.5(tr)-33.1(ansl)-16(a)14.9(t)-32(ional )0.5(success. )]TJ /T1_1 1 Tf 14.035 0 Td [(R)20.9(eg)11.9(en )0.5(Med.)]TJ /T1_0 1 Tf [( )0.5(2015;10\(1\):79\22696.)12( )]TJ 0 Tc 0 Tw -14.035 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.2217/r)-16(me.14.72)]TJ 0 0 0 1 k /GS1 gs 0.122 Tw -1.847 -1.25 Td (73.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gent)-32(ile)]TJ /Span<>> BDC ( )Tj EMC [(P, Or)-30(l)-16(andi)]TJ /Span<>> BDC ( )Tj EMC [(A, S)-24(c)-23.9(iol)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(MG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Conc)-23.9(ise r)-23.9(ev)-16(iew: adipose-)]TJ 0.272 Tw -1.796 -1.25 Td [(der)-37(i)-15.9(ved str)-32(omal v)-15(ascul)-16(ar fr)-33(a)-17(c)-16(t)-32(ion cells and pl)-15.9(a)15(tele)-12(t-r)-37(ich pl)-16(as)26(ma: )]TJ 0.153 Tw T* [(basic and cl)-30.9(inical im)10(pl)-31(ica)15(t)-32(ions for t)-32(issue engineer)-36.9(ing t)-13(her)-32.9(apies in )]TJ 0.29 Tw T* [(r)-24(egener)-32.9(a)15(t)-32(i)-16(ve sur)-31.9(ger)-24(y. )]TJ /T1_1 1 Tf [(S)28(tem Cells T)56(ransl Med.)]TJ /T1_0 1 Tf ( 2012;1\(3\):230\226236. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.5966/sc)-16(tm.2011-0054)]TJ 0 0 0 1 k /GS1 gs 0.043 Tw -1.847 -1.25 Td (74.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhu)Tj /Span<>> BDC ( )Tj EMC [(M, )0.5(He)-11(yd)42(ar)-24(khan-Ha)-16.9(gv)-15(all)]TJ /Span<>> BDC ( )Tj EMC [(S, )0.5(Hedr)-37(ick)]TJ /Span<>> BDC ( )Tj EMC [(M, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Manual isol)-15.9(a)15(t)-32(ion )]TJ 0.131 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(adipose-der)-36.9(i)-16(ved stem cells fr)-32(om human l)-31(ipoaspir)-32.9(a)15(tes. )]TJ /T1_1 1 Tf (J Vis Exp)Tj /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2013;\(79\):e50585. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3791/50585)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.364 Tw T* (75.)Tj /Span<>> BDC ( )Tj EMC 1.835 0 Td (\221\036\030\033\001\022\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\240.\230., \200\026\f\017\035\034\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\222., \200\026\032\036\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)10( )]TJ 0 Tc 0.252 Tw -1.835 -1.25 Td (\214\036\004\036\027\017\036 \035\031\004\036\r\t\b \030\036\022\021\024\ \r\026\020\017\027\026\035\034\027\t\b \f\r\017\013\036\005. )Tj /T1_1 1 Tf (\215\031\024\n\031\021\024\n\022\235 \200\022\032\r\032)Tj 0 Tw (-)Tj 0.039 Tw T* (\b\022\007\027\024\n\022\235 \255\r\032\025\020\f.)Tj /T1_0 1 Tf [( 2019;\(2\):53\22656. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.21518/1995-1477-2021-)Tj T* (18-1-82-90)Tj 0 0 0 1 k /GS1 gs 0.13 Tw [( / T)40(er)-24(yushkov)-14.9(a Zh.I., V)25(asil)35(yev)]TJ /Span<>> BDC ( )Tj EMC [(V.S., V)25(a)-24(zhenin)]TJ /Span<>> BDC ( )Tj EMC [(A.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.009 Tc 0.354 Tw T* [(T)49.6(r)-24.4(ea)14.6(tment of)]TJ /Span<>> BDC ( )Tj EMC [(R)-10.4(adia)14.5(t)-32.4(ion R)12.6(ec)-16.4(t)16.6(ov)-15.4(a)-17.5(ginal F)-19.4(istul)-16.4(as. )]TJ /T1_1 1 Tf [(Moscow Surgical)9( )]TJ 0.004 Tc -0.004 Tw 29.055 23.75 Td [(Jour)-14.4(nal.)]TJ /T1_0 1 Tf 0.35 Tw [( 2019;\(2\):53\22656. \(in Russ.\). d)-16.4(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw (10.21518/1995-1477-)Tj 0 Tc 0 Tw T* (2021-18-1-82-90)Tj 0 0 0 1 k /GS1 gs 0.002 Tw T* (76.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Cheng)Tj /Span<>> BDC ( )Tj EMC (F, Huang)Tj /Span<>> BDC ( )Tj EMC [(Z, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(Z. Ef)-56(f)-28(ica)-17(cy and Safe)-12(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(Mesenchymal S)15(tem )]TJ 0.221 Tw -1.796 -1.25 Td [(Cells )0.5(in )0.5(T)50(r)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 9.344 0 Td [(Com)10(ple)-18(x )0.5(P)30(er)-37(ianal F)-19(istul)-15.9(as: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC 12.425 0 Td [(Me)-12(t)15(a-Anal)35.1(y)-13(sis. )]TJ /T1_1 1 Tf 0.023 Tw -21.769 -1.25 Td [(S)28(tem Cells Int.)]TJ /T1_0 1 Tf [( 2020;2020:8816737. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2020/8816737)Tj 0 0 0 1 k /GS1 gs 0.018 Tc 0.662 Tw T* (77.)Tj /Span<>> BDC ( )Tj EMC 1.869 0 Td (\202\027\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\222., \213\030\t\001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\202., \216\030\033\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\224., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)18( )]TJ 0.01 Tc 0.375 Tw -1.869 -1.25 Td (\204\036\036\027\b\017\n\026\035\034\027\t\036 \f\021\r\024\035\024\r\t\ \036 \022\035\036\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \f\r\017\013\036\005 \023\036\030\017)Tj /Span<>> BDC (-)Tj EMC 0 Tc 0.296 Tw T* [(\026\027\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.266 0 Td [(\002\024\035\036\027\017 )0.5(\025\030\024\027\026 )0.5(\(\f\017\f\021\036\n\026\021\017\004\036\f\022\017\005 )0.6(\024\002\024\030 )]TJ 0.348 Tw -10.266 -1.25 Td (\035\017\021\036\030\026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_1 1 Tf 0 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf 0.348 Tw (. 2024;23\(3\):100\226)Tj 0.254 Tw T* [(111. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2024-23-3-100-111)Tj 0 0 0 1 k /GS1 gs 0.254 Tw ( / Anosov)Tj /Span<>> BDC ( )Tj EMC (I.S., )Tj 0.01 Tc 0.372 Tw T* [(Er)-23.9(y)-12.9(shov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(T.A., Khr)-24(yuk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(R.Y)35.1(u., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mesenchymal stem cells)10( )]TJ 0.004 Tc 0.35 Tw T* [(for per)-37.2(ianal f)-28.2(istul)-31.2(izing Cr)-32.2(ohn\241s disease \(sy)-13.2(stema)14.8(t)-32.2(ic r)-24.2(ev)-16.2(iew and)4( )]TJ 0 Tc 0 Tw T* [(me)-12.1(t)14.8(a-anal)34.9(y)-13.1(sis\). )]TJ /T1_1 1 Tf 6.786 0 Td [(K)17.9(olop)45.9(roktologia)]TJ /T1_0 1 Tf 0.35 Tw (. 2024;23\(3\):100\226111. \(in Russ.\). )Tj 0 Tw -6.786 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2024-23-3-100-111)Tj 0 0 0 1 k /GS1 gs -1.847 -1.25 Td (78.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Mahmud)Tj /Span<>> BDC ( )Tj EMC [(N, P)40(ang)]TJ /Span<>> BDC ( )Tj EMC (W, Cobbs)Tj /Span<>> BDC ( )Tj EMC [(C, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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End)-16(oscopic appl)-30.9(ica)15(t)-32(ion )]TJ 0.221 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(human f)-28(ibr)-37(in seal)-16(ant in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-23.9(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer )]TJ 0.004 Tc -0.004 Tw T* [(s)0.5(yn)0.5(d)0.5(r)-31.6(o)0.5(m)0.5(e.)0.5( )]TJ /T1_2 1 Tf 4.802 0 Td [(E)0.5(nd)0.5(o)0.5(sc)0.5(o)0.5(p)12.4(y)]TJ /T1_1 1 Tf 0.349 Tw 4.112 0 Td [(.)0.5(19)0.5(9)0.5(2;)0.5(24)0.5(\()0.5(8\))0.5(:)0.5(73)0.5(6)0.5(\2267)0.5(37)0.5(.)0.5( d)-15.6(o)0.5(i)0.5(:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.004 Tw [(1)0.5(0)0.5(.1)0.5(0)0.5(55)0.5(/s)0.5(-)0.5(2)0.5(00)0.5(7-)]TJ 0 Tc 0 Tw -8.914 -1.25 Td (1010574)Tj 0 0 0 1 k /GS1 gs 0.138 Tw T* (40.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Z)30(er)-32(gani)]TJ /Span<>> BDC ( )Tj EMC [(F)-10(J, S)-16(haiest)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC (AA, Hajiani)Tj /Span<>> BDC ( )Tj EMC [(E, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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End)-16(oscopic Submucosal )]TJ 0.014 Tc 0.52 Tw -1.796 -1.25 Td [(Dissec)-16.2(t)-32.2(ion Im)9.8(p)24.8(r)-32.1(oves Bl)29.8(o)-16.2(od)16.8(y S)14.8(t)16.8(o)-16.1(ol Asso)-16.2(c)-24.2(ia)14.8(ted wi)-24.1(t)-13.2(h P)9.9(ol)34.8(ypoid)14( )]TJ 0.01 Tc 0.385 Tw T* [(T)39.7(ype Mucosal P)34.7(r)-32.3(ol)-16.3(apse Syndr)-32.3(ome: A)]TJ /Span<>> BDC ( )Tj EMC [(Case Ser)-37.3(ies. )]TJ /T1_2 1 Tf [(Inter)-14.3(n Med.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2022;61\(21\):3211\2263215. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.2169/inter)-15(nalmedic)-23.9(ine.9182-21)]TJ 0 0 0 1 k /GS1 gs 0.008 Tc 0.349 Tw T* (45.)Tj /Span<>> BDC ( )Tj EMC 1.827 0 Td [(Ai)-23.8(t)17.1(ol)-15.8(a)]TJ /Span<>> BDC ( )Tj EMC [(PT, Hil)56.2(tunen)]TJ /Span<>> BDC ( )Tj EMC [(KM, Ma)15.2(t)-31.9(ik)-16.8(ainen)]TJ /Span<>> BDC ( )Tj EMC [(MJ. F)10.2(unc)-15.8(t)-31.8(ional r)-23.8(esul)56.2(ts)8( )]TJ 0 Tc 0.289 Tw -1.827 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(oper)-33(a)15(t)-31.9(i)-16(ve tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15(al p)25(r)-31.9(ol)-16(apse over an)]TJ /Span<>> BDC ( )Tj EMC [(11-year per)-37(i)]TJ 0 Tw (-)Tj 0.01 Tc 0.37 Tw T* [(od: em)10.1(phasis on tr)-32.9(ansabd)-15.9(ominal app)25.1(r)-31.9(oa)-16.9(ch. )]TJ /T1_2 1 Tf [(Dis Colon R)21.1(ectum)]TJ /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(1999;42\(5\):655\226660. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/BF02234145)Tj 0 0 0 1 k /GS1 gs 0.124 Tw T* (46.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gaj)Tj /Span<>> BDC ( )Tj EMC [(F, L)-32(ai)]TJ /Span<>> BDC ( )Tj EMC [(Q, Gel)30(or)-15.9(mini)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-56(f)-28(ica)-16.9(cy of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical tr)-23.9(ea)15(tments )]TJ 0.19 Tw -1.796 -1.25 Td [(for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-16.9(gement of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-24(t)15.1(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syndr)-32(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(ne)-12(t)-32(w)-14(or)-24(k )]TJ 0 Tw T* [(me)-12(t)15(a-anal)35.1(y)-13(sis. )]TJ /T1_2 1 Tf 0.155 Tw 6.22 0 Td (Colorectal Dis)Tj /T1_1 1 Tf [(. 2024;26\(8\):1515\226153. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/)Tj -6.22 -1.25 Td (codi.17080)Tj 0 0 0 1 k /GS1 gs 0.088 Tw T* (47.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\200\024\005\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \221\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \207\017\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \003\026\032\017\r\035\036\027\017\036 )Tj 0.344 Tw -1.796 -1.25 Td (\f\024\035\017\021\026\030\027\t\b \016\r \023\030\016\n\024\005 \022\017\ \001\022\017 \023\024\f\035\036 \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 \035\036\004\036\027\017\016 )Tj -0.025 Tw T* (\030\036\022\021\026\035\034\027\024\020\024 \023\030\024\035\026\023\f\026\ . \221\036\017\f\t XII \222\255\036\007\026 \b\017\030\031\030\020\024\ \r \217\024\f\f\017\017, \217\024\f\021\024\r-)Tj 0.129 Tw T* (\027\026-\212\024\027\031. 7\2269)Tj /Span<>> BDC ( )Tj EMC [(\024\022\021\016\002\030\016. 2015 \020., \f. 199. / V)29(oinov)]TJ /Span<>> BDC ( )Tj EMC [(M.A., T)35(i)-24(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., )]TJ 0.11 Tw T* [(Bir)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC [(O.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Heal)-30.9(ing of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer)-9.9(s af)-28(ter sur)-32(gical )]TJ -0.025 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al p)25(r)-32(ol)-16(apse. A)-14(bstr)-32.9(a)-17(c)-16(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he XII Congr)-24(ess of)]TJ /Span<>> BDC ( )Tj EMC (Russian )Tj 0.023 Tw T* [(Sur)-32(geons, R)11(ost)17.1(ov-on-Don. O)-16(c)-16(t)17.1(ober 7\2269. 2015; \030. 199. \(in Russ.\).)]TJ 0.066 Tw T* (48.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ihna)15(t)]TJ /Span<>> BDC ( )Tj EMC [(P, Mar)-21.9(t)-32(inek)]TJ /Span<>> BDC ( )Tj EMC [(L, V)25(avr)-33(a)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. N)-14(ovel combined app)25(r)-32(oa)-17(ch in )]TJ 0.153 Tw -1.796 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 1.736 0 Td [(mana)-17(gement )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.795 0 Td [(non-heal)-31(ing )0.5(sol)-30.9(i)-24(t)15(ar)-24(y )0.5(r)-24(ec)-16(t)15.1(al )0.5(ul)16(cer )0.5(syndr)-32(ome)]TJ /Span<>> BDC ( )Tj EMC 18.106 0 Td (\227 )Tj 0.162 Tw -26.638 -1.25 Td [(l)-16(ap)32(ar)-32(oscopic r)-23.9(esec)-16(t)-32(ion r)-24(ec)-16(t)17(ope)-17.9(xy and tr)-32.9(ansanal end)-16(oscopic micr)-32(o)]TJ 0 Tw (-)Tj T* [(sur)-32(ger)-23.9(y. )]TJ /T1_2 1 Tf 0.228 Tw 3.762 0 Td [(Wideochir Inne T)54(ech Maloin)12.1(w)13(azyjne)]TJ /T1_1 1 Tf (. 2015;10\(2\):295\226298. )Tj 0 Tw -3.762 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.5114/wi)-16(i)-23.9(tm.2015.52060)]TJ 0 0 0 1 k /GS1 gs 0.173 Tw -1.847 -1.25 Td (49.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(t)17(ol)56(tz)]TJ /Span<>> BDC ( )Tj EMC [(JF, de Isl)-16(a)]TJ /Span<>> BDC ( )Tj EMC [(N, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(YP, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)15(tem Cells and R)13(egener)-33(a)15(t)-32(i)-16(ve )]TJ 0.31 Tw -1.796 -1.25 Td [(Medic)-24(ine: M)16(y)-15.9(t)-13(h or R)13(eal)-30.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he 21t)-13(h Centur)-24(y. )]TJ /T1_2 1 Tf [(S)28(tem Cells Int)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2015;2015:734731. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2015/734731)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.371 Tw T* (50.)Tj /Span<>> BDC ( )Tj EMC 1.836 0 Td (\204\026\035\026\005\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \222\031\b\017\b)Tj /Span<>> BDC ( )Tj EMC [(\206.\221. \222\024\r\030\036\n\036\027\027\t\036)10( )]TJ 0 Tc 0.189 Tw -1.836 -1.25 Td (\023\030\036\007\f\021\026\r\035\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\017 \f\021\r\024\035\024\r\024\005 \022\035\ \036\021\022\017. )Tj /T1_2 1 Tf (\003\032\200\022\021 \033\020\023\031\f\031\b\022\022.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.228 Tw T* [(2002;64\(4\):7\22611. / Mal)-15.9(a)15(y)-16(tsev)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Bo)-15.9(gd)42(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (I.M., Sukhikh)Tj /Span<>> BDC ( )Tj EMC (G.T. )Tj 0.01 Tc 0.39 Tw T* [(M)-24.4(oder)-15.4(n )0.6(Concepts )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 9.519 0 Td [(S)14.5(tem )0.5(Cell )0.5(Biol)29.5(o)-16.4(g)15.5(y. )]TJ /T1_2 1 Tf 0.011 Tc 0.389 Tw 8.799 0 Td [(A)0.6(r)0.5(c)0.6(h)0.6(i)0.5(v)13.5(e)0.6( )0.6(o)0.5(f)]TJ /Span<>> BDC 4.362 0 Td ( )Tj EMC 0.632 0 Td [(P)18.6(a)0.5(t)0.6(h)0.5(o)0.6(l)0.6(o)0.5(g)0.6(y)0.5(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw 4.324 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (2002;64\(4\):7\22611. \(in Russ.\).)Tj 0.154 Tw T* (51.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\024\035\021\026\r\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\214.\202., \217\036\r\017\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \202\035\036\022\f\026\027\007\030\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.017 Tw -1.796 -1.25 Td (\203\036\005\030\026\035\034\027\t\036 \f\021\r\024\035\024\r\t\036 \017\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\036\027\017\021\024\030\027\t\036 \022\035\036\021\022\017\ \220\n\002\030\017\024\027\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\024)Tj 0 Tw (-)Tj 0.009 Tc 0.353 Tw T* (\007\024\r \004\036\035\024\r\036\022\026)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\f\027\024\r\026 \027\024\r\t\b \002\017\024\n\036\007\017\006\017\ \027\f\022\017\b \021\036\b\027\024\035\024\020\017\005.)9( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\217\025\023\031\b\027\025\027\016)Tj /T1_1 1 Tf 0.123 Tw [(. 2003;34\(3\):211\226215. / P)10(ol)56(t)15(av)-24(tsev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.A., R)13(ev)-16(ishin)]TJ /Span<>> BDC ( )Tj EMC (A.V., )Tj 0.038 Tw T* [(Alek)-9.9(sandr)-32(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(M.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Neur)-33(al stem and p)25(r)-32(o)-16(geni)-24(t)17(or cells of)]TJ /Span<>> BDC ( )Tj EMC (human )Tj 0.124 Tw T* [(embr)-24(yos )0.5(and fe)-12(tuses)]TJ /Span<>> BDC ( )Tj EMC [(\227 t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 11.886 0 Td (basis of)Tj /Span<>> BDC ( )Tj EMC 3.548 0 Td [(new biomedical )0.5(technol)30(o)-15.9(gies. )]TJ /T1_2 1 Tf 0 Tw -15.434 -1.25 Td [(Ontog)12(enesis)]TJ /T1_1 1 Tf 0.023 Tw (. 2003;34\(3\):211\226215. \(in Russ.\).)Tj 0.016 Tc 0.571 Tw T* (52.)Tj /Span<>> BDC ( )Tj EMC 1.859 0 Td (\222\031\b\017\b)Tj /Span<>> BDC ( )Tj EMC (\206.\221., \204\026\035\026\005\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)16.1( )]TJ 0 Tc 0.158 Tw -1.859 -1.25 Td (\204\036\036\027\b\017\n\026\035\034\027\t\036 \f\021\r\024\035\024\r\t\ \036 \022\035\036\021\022\017. )Tj /T1_2 1 Tf 0 Tw (\221\230\221\215)Tj /T1_1 1 Tf 0.158 Tw (. 2002;133\(2\):124\226131. )Tj 0.105 Tw T* (/ Sukhikh)Tj /Span<>> BDC ( )Tj EMC [(G.T., Mal)-16(a)15(y)-16(tsev)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Bo)-16(gd)42(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(I.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Mesenchymal )Tj 0.023 Tw T* (stem cells. )Tj /T1_2 1 Tf 0 Tw (BEBM)Tj /T1_1 1 Tf 0.023 Tw (. 2002;133\(2\):124\226131. \(in Russ.\).)Tj 0.238 Tw T* (53.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(imonson)]TJ /Span<>> BDC ( )Tj EMC 4.376 0 Td [(OE, )0.6(Domo)-16(ga)15(tsk)-17(a)15(y)22(a)]TJ /Span<>> BDC ( )Tj EMC 7.945 0 Td [(A, )0.6(V)29(ol)16(chkov)]TJ /Span<>> BDC ( )Tj EMC 5.241 0 Td [(P, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.468 0 Td [(al. )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 3.359 0 Td [(safe)-12(t)-10(y )]TJ 0.246 Tw -25.185 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(human pl)35(ur)-36.9(ipo)17(tent stem cells in cl)-31(inical tr)-24(ea)15(tment. )]TJ /T1_2 1 Tf (Ann Med.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2015;47\(5\):370\226380. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3109/07853890.2015.1051579)Tj 0 0 0 1 k /GS1 gs 0.232 Tw 29.055 81.25 Td (54.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\217\036\023\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\222, \217\032\026\027\017\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \231\026\n\036\027\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202. \233\n\002\030\017\024\027\026\035\034\027\t\036 )Tj 0.013 Tc 0.471 Tw -1.796 -1.25 Td (\f\021\r\024\035\024\r\t\036 \022\035\036\021\022\017: \235\031\027\007\026\ \n\036\027\021\026\035\034\027\026\016 \002\017\024\035\024\020\017\016 \ \017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\007\017\006\017\027\026.)13( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (\206\027\215\027\027\n\024)Tj /T1_1 1 Tf -0.039 Tw [(. 2002; 176 c./ R)13(epin)]TJ /Span<>> BDC ( )Tj EMC [(V.S., Rzhaninov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(A.A., S)-16(hamenkov)]TJ /Span<>> BDC ( )Tj EMC (D.A. )Tj 0.077 Tw T* [(Embr)-23.9(yonic S)15(tem Cells: )0.5(F)10(und)42(ament)15(al Biol)30(o)-16(g)16(y )0.5(and Medic)-24(ine. )]TJ /T1_2 1 Tf 0 Tw [(R)21(eMeT)54.1(e)-15(x.)]TJ /T1_1 1 Tf ( )Tj 0.023 Tw T* (2002; 176 p. \(in Russ.\).)Tj -0.011 Tw T* (55.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Ohlstein)Tj /Span<>> BDC ( )Tj EMC [(B, K)-16(ai)]TJ /Span<>> BDC ( )Tj EMC [(T, Deco)17(t)-30(t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(E, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(stem cell niche: t)-13(heme and )]TJ 0 Tw -1.796 -1.25 Td [(v)-15(ar)-36.9(ia)15(t)-32(ions. )]TJ /T1_2 1 Tf 0.067 Tw 4.668 0 Td [(Cur)-16(r Opin Cell Biol.)]TJ /T1_1 1 Tf [( 2004;16\(6\):693\226699. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -4.668 -1.25 Td (ceb.2004.09.003)Tj 0 0 0 1 k /GS1 gs 0.247 Tw T* (56.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\030\017\007\036\027\001\021\036\005\027)Tj /Span<>> BDC ( )Tj EMC (\202.\242., \214\026\035\t\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\025.\222. \230\027\007\031\022\006\017\016 \022\024\f\021\027\024\005 \021\ \022\026\027\017 )Tj 0.344 Tw -1.796 -1.25 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\036\024\020\036\027\027\t\036 \022\035\036\021\022\017-\023\030\ \036\007\001\036\f\021\r\036\027\027\017\022\017. \204., \204\036\007\017\ \006\017\027\026, 1973./ )Tj 0.004 Tw T* [(F)10(r)-37(idenshtein)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)50.1(a., L)-32(al)35.1(yk)-16(ina)]TJ /Span<>> BDC ( )Tj EMC [(K.S. Induc)-15.9(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(bone t)-32(issue and osteo)]TJ 0 Tw (-)Tj 0.023 Tw T* [(genic p)25(r)-23.9(ecur)-10(sor cells. M)-24(osco)-14(w, Medic)-23.9(ine. 1973. \(in Russ.\).)]TJ 0.033 Tw T* (57.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Majumd)42(ar)]TJ /Span<>> BDC ( )Tj EMC [(MK, T)47(hiede)]TJ /Span<>> BDC ( )Tj EMC [(MA. M)-24(osca)]TJ /Span<>> BDC ( )Tj EMC [(J.D. Pheno)17(t)-10(ypic and func)-16(t)-32(ional )]TJ 0.142 Tw -1.796 -1.25 Td [(com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(cul)56.1(tur)-24(es of)]TJ /Span<>> BDC ( )Tj EMC [(mar)-24(r)-32(o)-14(w-der)-36.9(i)-16(ved mesenchymal stem cells )]TJ 0.088 Tw T* [(and str)-31.9(omal cells. )]TJ /T1_2 1 Tf [(J Cell Ph)12(ysiol.)]TJ /T1_1 1 Tf [( 1998;176\(1\):57\22666. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/)Tj T* [(\(SICI\)1097-4652\(199807\)176:1<57::AID-JCP7>3.0.C)13.2(O;2-7)]TJ 0 0 0 1 k /GS1 gs 0.312 Tw T* (58.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)50(r)-24(emain)]TJ /Span<>> BDC ( )Tj EMC [(N, K)25.1(or)-24(kko)]TJ /Span<>> BDC ( )Tj EMC [(J, Ibber)-9.9(son)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Micr)-32(oSA)16(GE anal)35(y)-13(sis )]TJ 0.179 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(2353 e)-18(xp)25(r)-24(essed genes in a)]TJ /Span<>> BDC ( )Tj EMC [(single cell-der)-37(i)-15.9(ved col)30(ony of)]TJ /Span<>> BDC ( )Tj EMC (undif)Tj 0 Tw (-)Tj -0.007 Tw T* [(fer)-23.9(ent)-32(ia)15(t)-32(ia)15(ted )0.5(human )0.5(mesenchymal )0.5(stem )0.5(cells )0.5(r)-23.9(eveals )0.5(mRN)13(A)35(S )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (mul)Tj 0 Tw (-)Tj 0.141 Tw T* [(t)-32(iple cell l)-31(inea)-17(ges. )]TJ /T1_2 1 Tf [(S)28(tem Cells)]TJ /T1_1 1 Tf [(. 2001;19\(5\):408\226418. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1634/)Tj T* (stemcells.19-5-408)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.365 Tw T* (59.)Tj /Span<>> BDC ( )Tj EMC 1.835 0 Td [(Al)-30.7(ison)]TJ /Span<>> BDC ( )Tj EMC [(MR, P)10.2(oulsom)]TJ /Span<>> BDC ( )Tj EMC [(R, Ot)-29.7(t)17.2(o)]TJ /Span<>> BDC ( )Tj EMC [(WR, e)-11.8(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Sur)-32.2(gical tr)-24.2(ea)14.8(tment)6.1( )]TJ 0 Tc 0.051 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(f)16(amil)-30.9(ial adenoma)15.1(t)16.9(ous )0.5(pol)35(yposis )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30.1(on using cell)35.1(ul)-16(ar r)-24(econ)]TJ 0 Tw (-)Tj 0.105 Tw T* [(str)-21.9(uc)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-15.9(t)15(al mucosa. )]TJ /T1_2 1 Tf 0 Tw [(K)18(olop)46.1(roktologia)]TJ /T1_1 1 Tf 0.105 Tw (. 2017;\(3S\):84a\22685. )Tj 0.023 Tw T* (\(in Russ.\).)Tj 0.131 Tw T* (62.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Hung)Tj /Span<>> BDC ( )Tj EMC (SC, Chen)Tj /Span<>> BDC ( )Tj EMC (NJ, Hsieh)Tj /Span<>> BDC ( )Tj EMC [(SL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Isol)-16(a)15.1(t)-32(ion and char)-32.9(a)-17(c)-16(ter)-37(iza)]TJ 0 Tw (-)Tj 0.071 Tw -1.796 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(size-sieved stem cells fr)-32(om human bone mar)-24(r)-32(o)-14(w. )]TJ /T1_2 1 Tf [(S)28(tem Cells.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2002;20\(3\):249\22658. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1634/stemcells.20-3-249)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.446 Tw T* (63.)Tj /Span<>> BDC ( )Tj EMC 1.844 0 Td (\215\036\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \230\r\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\233.\203., \215\036\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC [(\224.\202. \222\021\r\024\035\024\r\t\036)12( )]TJ 0.005 Tc 0.35 Tw -1.844 -1.25 Td (\022\035\036\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\030\024\r\024\005 \021\022\026\027\017. )Tj /T1_2 1 Tf -0.005 Tw (\221io\023\027\200\025\031\f\031\bi\t)Tj /T1_1 1 Tf 0.35 Tw [(. 2008;1\(4\):39\22647. /)5( )]TJ 0 Tc 0.064 Tw T* [(P)30(e)-12(tr)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., Iv)-15(anov)]TJ /Span<>> BDC ( )Tj EMC [(E.N., P)30(e)-12(tr)-23.9(enko Y)35(u.A. 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M)-24(or)-24(eir)-32.9(a V)-15(icente)]TJ /Span<>> BDC ( )Tj EMC [(V, R)13(ed)-16(ond)-16(o V)30(er)-31.9(ge)]TJ /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.144 Tw -1.296 -1.25 Td [(Enfer)-15.9(med)42(ad de )0.5(l)-16(a )0.5(tr)-24(es )0.5(ment)-31.9(ir)-33(as: )0.5(s\355ndr)-32(ome )0.5(de )0.5(l)-16(a )0.5(\372l)16(cer)-33(a )0.5(r)-24(ec)-16(t)15(al )0.5(sol)-30.9(i)]TJ 0 Tw (-)Tj 0 -1.25 TD [(t)15(ar)-37(ia. )]TJ /T1_1 1 Tf 0.074 Tw 2.497 0 Td [(R)21(ev Esp Enfer)-14(m Dig. )]TJ /T1_0 1 Tf [(2007;99\(11\):663\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.4321/s1130-)Tj -2.497 -1.25 Td (01082007001100009)Tj 0 0 0 1 k /GS1 gs 0.026 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(or)-32(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M, Dar)-32(v)-15.9(ishi)]TJ /Span<>> BDC ( )Tj EMC [(M. S)-16(ol)-31(i)-24(t)15(ar)-23.9(y r)-24(ec)-16(t)15.1(al ul)16(cer syndr)-32(ome: A)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stem)]TJ 0 Tw (-)Tj -0.016 Tw -1.296 -1.25 Td [(a)15(t)-32(ic r)-24(ev)-15.9(iew. )]TJ /T1_1 1 Tf (Medicine \(Baltimore\).)Tj /T1_0 1 Tf [( 2018;97\(18\):e0565. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (MD.0000000000010565)Tj 0 0 0 1 k /GS1 gs 0.255 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Sadeghi)Tj /Span<>> BDC ( )Tj EMC [(A, Bigl)-16(ar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(M, F)10(or)-32(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-31(i)-23.9(t)15(ar)-24(y R)13(ec)-16(t)15(al Ul)16(cer )]TJ -0.053 Tw -1.296 -1.25 Td [(Syndr)-32(ome: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC [(Nar)-24(r)-32.9(a)15(t)-32(i)-16(ve )0.5(R)13(ev)-16(iew)]TJ /T1_1 1 Tf [(. Middle )0.5(East )0.5(J Dig )0.5(Dis.)]TJ /T1_0 1 Tf ( 2019;11\(3\):129\226)Tj 0.023 Tw T* [(134. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.15171/mejdd.2019.138)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Ok)-17(a)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(K, Aok)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, Ued)42(a)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnost)-32(ic techniques for r)-24(ec)-16(t)15(al )]TJ -0.005 Tw -1.296 -1.25 Td [(mucosal p)25(r)-32(ol)-16(apse syndr)-32(ome. )]TJ /T1_1 1 Tf [(Nihon Syouk)11(aki N)18(aishikyou Gakk)11(ai Zasshi )]TJ 0.023 Tw T* (\(Gastroenterol Endosc\).)Tj /T1_0 1 Tf ( 2014;56:494\226503.)Tj 0.225 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(an)]TJ /Span<>> BDC ( )Tj EMC (Q, Zhou)Tj /Span<>> BDC ( )Tj EMC (J, Zhao)Tj /Span<>> BDC ( )Tj EMC [(K, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(r)-33(ar)-23.9(e case r)-24(epor)-21.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(muc)-24(inous )]TJ 0.125 Tw -1.296 -1.25 Td [(adeno)-16(car)-32(c)-24(inoma e)-18(x)-10.9(a)-17(cer)-24(ba)15(ted b)12(y l)30(ong-st)15(anding sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer )]TJ 0 Tw T* [(syndr)-32(ome. )]TJ /T1_1 1 Tf 0.023 Tw 4.44 0 Td [(AME Case R)21(ep.)]TJ /T1_0 1 Tf [( 2024;24\(8\):63. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.21037/a)-17(cr-23-207)]TJ 0 0 0 1 k /GS1 gs 0.098 Tw -4.44 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(A)-14(bid)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(cl)-31(inical, end)-16(oscopic and hist)17(ol)30(o)-16(gical spec)-16(tr)-22(um )]TJ 0.232 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he sol)-31(i)-24(t)15(ar)-23.9(y r)-24(ec)-15.9(t)15(al ul)16(cer syndr)-31.9(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(single-center e)-18(xper)-37(ience )]TJ 0.213 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC (116 cases. )Tj /T1_1 1 Tf (BMC Gastroenterol.)Tj /T1_0 1 Tf [( 2012;12:72. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1471-)Tj T* (230X-12-72)Tj 0 0 0 1 k /GS1 gs 0.127 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Dehghani)Tj /Span<>> BDC ( )Tj EMC [(SM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-31(i)-24(t)15.1(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syndr)-32(ome: Is i)-24(t r)-23.9(eall)35(y )]TJ 0.224 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(r)-33(ar)-23.9(e condi)-24(t)-32(ion in )0.5(childr)-24(en? )]TJ /T1_1 1 Tf [(W)29(orld )0.5(Jour)-14(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(Clinical )0.5(P)15(ediatr)-36.9(ics.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2016;5\(3\):343\226348. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.5409/wjcp.v5.i3.343)Tj 0 0 0 1 k /GS1 gs 0.003 Tc 0.349 Tw T* [(1)0.5(1)0.5(.)]TJ /Span<>> BDC 1.303 0 Td ( )Tj EMC 0.502 0 Td [(S)0.5(a)0.5(f)16.6(a)0.5( O)0.5(u)0.5(r)-36.4(i)0.5(d)42.5(a)0.5(,)0.6( M)0.5(a)0.6(r)-36.5(i)0.5(e)0.6(m)0.5( E)0.5(l)0.5(l)0.6(e)0.5(u)0.5(c)0.6(h)0.5(,)0.5( I)0.5(n)0.5(e)0.6(s)0.5( L)-31.4(a)0.5(m)0.5(l)30.6(o)0.5(u)0.5(m)0.6(,)0.5( e)-11.4(t)]TJ /Span<>> BDC 20.574 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( S)-15.5(o)0.6(l)56.5(t)15.5(a)0.6(i)0.5(r)-23.5(y)3( )]TJ 0 Tc 0.283 Tw -22.38 -1.25 Td [(R)13(ec)-16(t)15(al Ul)16(cer Syndr)-32(ome: An)]TJ /Span<>> BDC ( )Tj EMC [(E)35(x)-13(cept)-31.9(ional Ent)-32(i)-24(t)-10(y in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Elder)-30(l)35(y. )]TJ /T1_1 1 Tf 0 Tw (J. )Tj 0.022 Tc 0.809 Tw T* [(Gastroenterology P)17.6(ancreatology and Hepatobilar)-43.4(y Disorder.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2021;5\(4\):01\22602. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.31579/2641-5194/033)Tj 0 0 0 1 k /GS1 gs -0.017 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(KR, R)-24(iddell)]TJ /Span<>> BDC ( )Tj EMC 7.253 0 Td [(RH. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-24(t)15(ar)-23.9(y ul)16(cer syndr)-32(ome of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-16(tum. )]TJ /T1_1 1 Tf 0.023 Tw -9.049 -1.25 Td (Clin Gastroenterol)Tj /T1_0 1 Tf (. 1975;4\(3\):505\226530.)Tj 0.048 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Du Boul)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(CE, F)20(air)-23.9(br)-32(o)17(t)-13(her)]TJ /Span<>> BDC ( )Tj EMC [(J, Isaa)-17(cson)]TJ /Span<>> BDC ( )Tj EMC [(PG. Mucosal p)25(r)-32(ol)-16(apse syn)]TJ 0 Tw (-)Tj 0.029 Tw -1.796 -1.25 Td [(dr)-32(ome)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(unif)-34(ying concept for sol)-31(i)-24(t)15(ar)-23.9(y ul)16.1(cer syndr)-32(ome and r)-24(el)-15.9(a)15(ted )]TJ 0 Tw T* [(disor)-24(der)-9.9(s. )]TJ /T1_1 1 Tf 0.333 Tw 4.549 0 Td [(J )0.5(Clin )0.5(P)18(athol)]TJ /T1_0 1 Tf [(. )0.5(1983;36\(11\):1264\2261268. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 19.349 0 Td (10.1136/)Tj -23.899 -1.25 Td (jcp.36.11.1264)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.383 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.837 0 Td [(P)39.7(ar)-24.3(k)-10.2(s)]TJ /Span<>> BDC ( )Tj EMC [(A)15.7(G, P)9.8(or)-22.2(ter)]TJ /Span<>> BDC ( )Tj EMC [(NH, Har)-24.3(dcastle)]TJ /Span<>> BDC ( )Tj EMC [(J. T)46.7(he)]TJ /Span<>> BDC ( )Tj EMC [(syndr)-32.3(ome of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.2(he)10( )]TJ 0.012 Tc 0.456 Tw -1.837 -1.25 Td [(descending per)-37.3(ineum. )]TJ /T1_1 1 Tf (Proc R Soc Med)Tj /T1_0 1 Tf [(. 1966;59\(6\):477\226482.)12( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/003591576605900601)Tj 0 0 0 1 k /GS1 gs -0.034 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ni)-16(v)]TJ /Span<>> BDC ( )Tj EMC [(Y, S)-16(hemesh)]TJ /Span<>> BDC ( )Tj EMC [(E, Ba)15(t)]TJ /Span<>> BDC ( )Tj EMC [(L. S)-16(ol)-31(i)-24(t)15.1(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer syndr)-31.9(ome. )]TJ /T1_1 1 Tf 0 Tw (Harefuah.)Tj /T1_0 1 Tf ( )Tj -1.796 -1.25 Td (1981;100\(12\):581\226583.)Tj 0.278 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(T)40(and)-16(on)]TJ /Span<>> BDC ( )Tj EMC [(RK, A)30(tmakur)-36.9(i)]TJ /Span<>> BDC ( )Tj EMC [(SP, Mehr)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(NK, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Is sol)-31(i)-24(t)15(ar)-24(y r)-24(ec)-15.9(t)15(al )]TJ 0.21 Tw -1.796 -1.25 Td [(ul)16(cer a)]TJ /Span<>> BDC ( )Tj EMC [(manifest)15(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stemic disease? )]TJ /T1_1 1 Tf (J Clin Gastroenterol. )Tj /T1_0 1 Tf 0.023 Tw T* [(1990;12\(3\):286\226290. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00004836-199006000-00010)Tj 0 0 0 1 k /GS1 gs 0.086 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Contr)-33(a)-17(c)-15.9(t)17(or)]TJ /Span<>> BDC ( )Tj EMC 4.587 0 Td [(T)25(Q, )0.5(Contr)-33(a)-17(c)-16(t)17(or)]TJ /Span<>> BDC ( )Tj EMC 6.083 0 Td [(QQ. )0.5(T)50(r)-33(auma)15(t)-32(ic )0.5(sol)-31(i)-24(t)15.1(ar)-24(y )0.5(r)-24(ec)-16(t)15(al )0.5(ul)16(cer )0.5(in )]TJ -0.002 Tw -12.466 -1.25 Td [(Saudi Ar)-32.9(abia. A)]TJ /Span<>> BDC ( )Tj EMC [(dist)-32(inc)-16(t ent)-32(i)-24(t)-10(y? )]TJ /T1_1 1 Tf (J Clin Gastroenterol)Tj /T1_0 1 Tf ( 1995;21\(4\):298\226)Tj 0.023 Tw T* [(300. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00004836-199512000-00010)Tj 0 0 0 1 k /GS1 gs 0.224 Tw T* (18.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(r)-24(eimanis)]TJ /Span<>> BDC ( )Tj EMC [(MG, W)12(ald)]TJ /Span<>> BDC ( )Tj EMC [(A, Car)-21.9(uana)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ev)-15(a)-17(cua)15(t)-32(ion p)25(r)-32(o)-16(c)-15.9(t)17(o)-16(g)]TJ 0 Tw (-)Tj 0.342 Tw -1.796 -1.25 Td [(r)-33(aphy in nor)-16(mal vol)35.1(unteer)-10(s. )]TJ /T1_1 1 Tf [(In)11(v)13(est R)20(adiol.)]TJ /T1_0 1 Tf ( 1991;26\(6\):581\226585. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1097/00004424-199106000-00015)Tj 0 0 0 1 k /GS1 gs 0.044 Tw -1.847 -1.25 Td (19.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (He)Tj /Span<>> BDC ( )Tj EMC [(CC, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC (SP, Zhou)Tj /Span<>> BDC ( )Tj EMC [(PR, e)-12(t al. Inher)-36.9(i)-24(ted CHEK2 p.H371Y mut)15(a)]TJ 0 Tw (-)Tj 0.335 Tw -1.796 -1.25 Td [(t)-32(ion in sol)-31(i)-24(t)15.1(ar)-24(y r)-24(ec)-15.9(t)15(al ul)16(cer syndr)-32(ome among f)16(amil)-31(ial p)32(a)15(t)-32(ients: )]TJ 0.01 Tc 0.364 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(case r)-23.8(epor)-21.8(t. )]TJ /T1_1 1 Tf [(W)29.3(orld J Gastroenterol.)]TJ /T1_0 1 Tf [( 2023;29\(31\):4809\2264814.)10( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.3748/wjg.v29.i31.4809)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.454 Tw -1.847 -1.25 Td (20.)Tj /Span<>> BDC ( )Tj EMC 1.845 0 Td (\207\024\002\030\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\207. \222\017\027\007\030\024\n \f\024\035\017\021\026\030\027\024\ \005 \016\r\t \023\030\016\n\024\005 \022\017\001\022\017.)12( )]TJ /T1_1 1 Tf 0 Tc 0 Tw -1.845 -1.25 Td (\230\025\030\031\024\n\031\033\022\t)Tj /T1_0 1 Tf 0.125 Tw [(. 2013;2:18\22622./ Bobr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.B. S)-16(ol)-31(i)-23.9(t)15(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syn)]TJ 0 Tw (-)Tj T* [(dr)-32(ome. )]TJ /T1_1 1 Tf 3.087 0 Td [(Endoscop)12.1(y)]TJ /T1_0 1 Tf 0.023 Tw (. 2013;2:18\22622. \(in Russ.\).)Tj 0.018 Tw -3.087 -1.25 Td (21.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Huang)Tj /Span<>> BDC ( )Tj EMC [(Y, L)-31.9(in)]TJ /Span<>> BDC ( )Tj EMC (X, Han)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(oscopic fea)15(tur)-24(es of)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al muco)]TJ 0 Tw (-)Tj -0.004 Tw -1.796 -1.25 Td [(sal p)25(r)-32(ol)-15.9(apse syndr)-32(ome \(RMPS\): Dif)-56(fer)-23.9(ent)-32(ia)15(t)-32(ion fr)-31.9(om mal)-31(ignant r)-24(ec)-16(t)15(al )]TJ 0 Tw T* (tumor)Tj /T1_1 1 Tf 0.016 Tw (. Endosc Int Open.)Tj /T1_0 1 Tf [( 2024;12\(11\):E1303\226E1308. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1055/a-)Tj T* (2390-2946)Tj 0 0 0 1 k /GS1 gs 0.293 Tw T* (22.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)20(ong)]TJ /Span<>> BDC ( )Tj EMC [(YP, K)-16(abincona)]TJ /Span<>> BDC ( )Tj EMC (C, Jabar)Tj /Span<>> BDC ( )Tj EMC [(MF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(ec)-16(t)15(al P)10(ol)35(yposis in )]TJ 0.243 Tw -1.796 -1.25 Td [(Mucosal P)35(r)-32(ol)-15.9(apse Syndr)-32(ome. )]TJ /T1_1 1 Tf (Diagnostics \(Basel\).)Tj /T1_0 1 Tf ( 2022;12\(4\):966. )Tj 0 Tw 0 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.3390/dia)-17(gnost)-31.9(ics12040966)]TJ 0 0 0 1 k /GS1 gs 0.178 Tw -1.847 -1.25 Td (23.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Es)26(maeil)35(y)]TJ /Span<>> BDC ( )Tj EMC 3.855 0 Td [(H)49(A. )0.5(Hist)17(op)32(a)15(t)-13(hol)30.1(o)-16(gical )0.5(misdia)-17(gnosis )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y )0.5(r)-24(ec)-16(t)15(al )]TJ 0.016 Tw -5.651 -1.25 Td [(ul)16(cer syndr)-32(ome. )]TJ /T1_1 1 Tf [(R)21(esearch jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC (biological sciences.)Tj /T1_0 1 Tf ( 2008;3:1171.)Tj -0.055 Tw T* (24.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-33(ak)-17(ash)]TJ /Span<>> BDC ( )Tj EMC [(N, V)-16(y)22(as)]TJ /Span<>> BDC ( )Tj EMC [(SJ, M)-23.9(ohammed)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Infl)-16(amma)15.1(t)17(or)-24(y Cl)30(oa)-17(co)-16(genic )]TJ 0.129 Tw -1.796 -1.25 Td [(P)10(ol)35(yp: A)]TJ /Span<>> BDC ( )Tj EMC [(R)-10(ar)-24(e Benign Col)30(or)-23.9(ec)-16(t)15(al P)10(ol)35(yp. )]TJ /T1_1 1 Tf 0 Tw (Cureus.)Tj /T1_0 1 Tf 0.129 Tw ( 2022;14\(2\):e22014. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.7759/cur)-23.9(eus.22014)]TJ 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw 27.208 81.25 Td (25.)Tj /Span<>> BDC ( )Tj EMC 1.805 0 Td [(L)34.6(ev)-16.4(ine)]TJ /Span<>> BDC ( )Tj EMC [(DS. \236S)-16.4(ol)-31.3(i)-24.4(t)14.7(ar)-24.4(y\237 r)-24.4(ec)-16.4(t)14.7(al ul)15.7(cer syndr)-32.4(ome. Ar)-24.4(e \236sol)-31.4(i)-24.3(t)14.6(ar)-24.4(y\237)2.1( )]TJ 0.007 Tc -1.805 -1.25 Td [(r)-24.3(ec)-16.4(t)14.7(al ul)15.7(cer syndr)-32.3(ome and \236l)29.6(o)-16.3(cal)-31.3(ized\237 col)-31.3(i)-24.4(t)-32.3(is cy)-13.3(st)-32.4(ica p)24.7(r)-32.3(ofund)41.7(a)7( )]TJ 0 Tc 0.176 Tw T* [(anal)30(o)-16(gous syndr)-31.9(omes caused b)12(y r)-24(ec)-15.9(t)15(al p)25(r)-32(ol)-16(apse? )]TJ /T1_1 1 Tf 0 Tw (Gastroenterology.)Tj /T1_0 1 Tf ( )Tj T* (1987;92\(1\):243\226253.)Tj 0.153 Tw T* (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)20(ong)]TJ /Span<>> BDC ( )Tj EMC [(W, L)-32(ai)]TJ /Span<>> BDC ( )Tj EMC [(K, S)-16(hek)]TJ /Span<>> BDC ( )Tj EMC [(T)-48(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Self-infl)-30.9(ic)-16(ted r)-24(ec)-16(t)15(al ul)16(cer wi)-23.9(t)-13(h )]TJ 0.111 Tw -1.796 -1.25 Td [(e)-18(xuber)-32.9(ant gr)-33(anul)-16(a)15(t)-32(ion t)-13(ha)15.1(t mimics car)-32(c)-24(inoma. )]TJ /T1_1 1 Tf (Gastrointest Endosc.)Tj /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2002;55\(7\):951\226952. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1067/mge.2002.124556)Tj 0 0 0 1 k /GS1 gs 0.165 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\036\030\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC [(\202.\213., )0.5(\221\030\031\002\026\004\036\r\026)]TJ /Span<>> BDC ( )Tj EMC 10.99 0 Td (\224.\214., \200\t\001\036\020\024\030\024\007\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \017)Tj /Span<>> BDC ( )Tj EMC 12.302 0 Td (\f\024\026\r\021. )Tj 0.009 Tc 0.351 Tw -25.088 -1.25 Td (\211\035\034\021\030\026\r\031\022\024\r\026\016 \007\017\026\020\027\024\ \f\021\017\022\026 \f\017\027\007\030\024\n\026 \f\024\035\017\021\026\030\ \027\024\005 \016\r\t \023\030\016)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.584 Tw T* (\n\024\005 \022\017\001\022\017 \(\024\002\024\030 \035\017\021\036\030\ \026\021\031\030\t \017)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\017\036 \023\030\017\n\036\030\t\).)16( )]TJ /T1_1 1 Tf 0.014 Tc -0.014 Tw T* (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_0 1 Tf 0.515 Tw [( 2022;21\(4\):100\226110. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.014 Tw (10.33878/2073-)Tj 0.016 Tc -0.016 Tw T* (7556-2022-21-4-100-110)Tj 0 0 0 1 k /GS1 gs 0.572 Tw [( / P)30.4(er)-9.6(shina)]TJ /Span<>> BDC ( )Tj EMC [(A.E., T)50.4(r)-21.7(uba)-16.7(chev)-14.6(a Y)35.3(u.L.,)16( )]TJ 0 Tc 0.083 Tw T* [(V)-16(y)-13(shegor)-31.9(od)17(tsev)]TJ /Span<>> BDC ( )Tj EMC [(D.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ul)56(tr)-32.9(asono)-16(gr)-33(aphy for sol)-31(i)-23.9(t)15(ar y r)-24(ec)-16(t)15(al)35(ul)16(cer )]TJ 0.021 Tw T* [(\(r)-24(ev)-15.9(iew and case r)-24(epor)-21.9(ts\). )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46.1(roktologia)]TJ /T1_0 1 Tf 0.021 Tw (. 2022;21\(4\):100\226110. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2022-21-4-100-110)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.465 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.846 0 Td (\215\036\030\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\213., \221\030\031\002\026\004\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\214., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0.012 Tc 0.452 Tw -1.846 -1.25 Td [(\211\035\034\021\030\026\r\031\022\024\r\026\016 \f\036\n\017\024\021\017\ \022\026 \f\024\035\017\021\026\030\027\024\005 \016\r\t \023\030\016\n\ \024\005 \022\017\001\022\017.)12( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf 0.321 Tw [(. 2024;23\(2\):68\22675. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2024-23-2-68-75)Tj 0 0 0 1 k /GS1 gs 0.338 Tw [( / P)30(er)-10(shina)]TJ /Span<>> BDC ( )Tj EMC [(A.E., T)50(r)-22(uba)-16.9(chev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(Y.L., V)29.9(esel)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (V.V., )Tj 0.219 Tw T* [(Bir)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC (O.M.,)Tj /Span<>> BDC ( )Tj EMC [(e)-12(t al. Ul)56(tr)-32.9(asound semio)17(t)-32(ics of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al)35(ul)16(cer. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.039 Tw [(. 2024;23\(2\):68\22675. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2024-23-2-68-75)Tj 0 0 0 1 k /GS1 gs 0.295 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(A)-14(bdel)-16(a)15.1(t)-30(t)-10(y)]TJ /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ol)-30.9(i)-24(t)15(ar)-24(y r)-23.9(ec)-16(t)15(al ul)16(cer syndr)-31.9(ome \(SR)12(US\): )]TJ 0.201 Tw -1.796 -1.25 Td [(obser)-32(v)-15(a)15.1(t)-32(ional case ser)-36.9(ies f)-28(indings on MR defeco)-15.9(gr)-33(aphy. )]TJ /T1_1 1 Tf 0 Tw (European )Tj 0.013 Tc -0.013 Tw T* [(R)20(adiology.)]TJ /T1_0 1 Tf 0.48 Tw [( )0.5(2021;31\(11\):8597\2268605. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.013 Tw 18.571 0 Td (10.1007/s00330-021-)Tj 0 Tc 0 Tw -18.571 -1.25 Td (08075-6)Tj 0 0 0 1 k /GS1 gs 0.024 Tc 0.871 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.893 0 Td (\231\036\035\t\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \025\035\017\027\017\004\036\f\022\017\036 \030\036\022\ \024\n\036\027\007\026)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.581 Tw -1.893 -1.25 Td [(\006\017\017. )0.5(\200\t\023\026\007\036\027\017\036 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\(\02562.2, )0.6(\02562.3\) )0.5(\r\030\024\f\035\t\036.)16( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_0 1 Tf 0.321 Tw [( 2024;23\(3\):10\22622. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-)Tj T* (2024-23-3-10-22)Tj 0 0 0 1 k /GS1 gs 0.168 Tw [( )0.5(/ )0.5(S)-16(hel)35(ygin)]TJ /Span<>> BDC ( )Tj EMC 11.984 0 Td [(Y.A., )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 3.444 0 Td [(al. )0.5(Cl)-31(inical )0.6(guidel)-31(ines. )0.5(R)13(ec)-16(t)15(al )]TJ 0.014 Tw -15.428 -1.25 Td [(p)25(r)-32(ol)-16(apse \(62.2, 62.3\), adul)56.1(ts. )]TJ /T1_1 1 Tf 0 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.014 Tw (. 2024;23\(3\):10\22622. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-7556-2024-23-3-10-22)Tj 0 0 0 1 k /GS1 gs 0.212 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)-16(kno)-16(os)]TJ /Span<>> BDC ( )Tj EMC (SJ, Nicholls)Tj /Span<>> BDC ( )Tj EMC [(RJ, Henr)-23.9(y)]TJ /Span<>> BDC ( )Tj EMC [(MM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Elec)-16(tr)-32(ophy)-12.9(siol)30(o)-16(gical )]TJ 0.126 Tw -1.796 -1.25 Td [(and manome)-12(tr)-36.9(ic assess)26.1(ment of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he pel)30(v)-16(ic fl)30(o)-16(or in t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)-24(t)15(ar)-24(y r)-23.9(ec)]TJ 0 Tw (-)Tj 0.149 Tw T* [(t)15(al )0.5(ul)16(cer )0.6(syndr)-32(ome. )]TJ /T1_1 1 Tf 8.367 0 Td [(Br )0.5(J )0.5(Surg.)]TJ /T1_0 1 Tf [( )0.5(1985;72\(2\):131\226133. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 15.531 0 Td (10.1002/)Tj -23.899 -1.25 Td (bjs.1800720221)Tj 0 0 0 1 k /GS1 gs 0.006 Tw T* (32.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(or)-37(io)]TJ /Span<>> BDC ( )Tj EMC [(O, Meur)-23.9(e)-12(t)-30(te)]TJ /Span<>> BDC ( )Tj EMC [(G, Desfour)-14.9(neaux)]TJ /Span<>> BDC ( )Tj EMC [(V, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Anor)-24(ec)-16(t)15.1(al phy)-13(siol)30.1(o)-16(g)16(y )]TJ 0.039 Tw -1.796 -1.25 Td [(in sol)-31(i)-24(t)15(ar)-24(y ul)16(cer syndr)-32(ome: a)]TJ /Span<>> BDC ( )Tj EMC [(case-ma)15(tched ser)-37(ies. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2005;48\(10\):1917\2261922. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10350-005-0105-x)Tj 0 0 0 1 k /GS1 gs 0.255 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)25(uck)10(elman)]TJ /Span<>> BDC ( )Tj EMC (J, Johnson)Tj /Span<>> BDC ( )Tj EMC [(EK. \236S)-16(ol)-31(i)-24(t)15(ar)-23.9(y R)13(ec)-16(t)15(al Ul)16(cer Syndr)-32(ome\237. )]TJ 0.032 Tw -1.796 -1.25 Td [(Chapter in: Cl)-31(inical al)16(gor)-37(i)-23.9(t)-13(hms in gener)-32.9(al sur)-31.9(ger)-24(y: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-33(a)-17(c)-15.9(t)-32(ical guide. )]TJ /T1_1 1 Tf 0.023 Tw T* [(Cham: Sp)46(r)-36.9(ing)12(er.)]TJ /T1_0 1 Tf ( 2019; pp. 269\226274)Tj 0.12 Tw T* (34.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Gour)-36.9(iou)]TJ /Span<>> BDC ( )Tj EMC [(C, Chamba)-24(z)]TJ /Span<>> BDC ( )Tj EMC [(M, R)11(oper)-22(t)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15(t)-32(ic l)-31(i)-23.9(ter)-33(a)15(tur)-24(e )]TJ 0.255 Tw -1.796 -1.25 Td [(r)-24(ev)-15.9(iew on sol)-30.9(i)-24(t)15(ar)-24(y r)-24(ec)-16(t)15(al ul)16(cer syndr)-31.9(ome: is t)-12.9(her)-24(e a)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(her)-33(apeut)-32(ic )]TJ 0.218 Tw T* (consensus in 2018? )Tj /T1_1 1 Tf (Int J Colorectal Dis. 2018;)Tj /T1_0 1 Tf 0 Tw (33\(12\):1647\2261655. )Tj T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-018-3162-z)Tj 0 0 0 1 k /GS1 gs 0.138 Tw -1.847 -1.25 Td (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Qar)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(Y, M)-24(osl)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC (M. A)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-16(iew and me)-12(t)15(a-anal)35.1(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )]TJ 0.325 Tw -1.796 -1.25 Td [(ef)-56(f)-28(ica)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC [(medical tr)-23.9(ea)15(tments for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-16.9(gement of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-31(i)-24(t)15(ar)-23.9(y )]TJ 0.005 Tc 0.349 Tw T* [(r)-23.7(ec)-15.7(t)15.3(al ul)16.3(cer syndr)-31.7(ome)]TJ /T1_1 1 Tf (. Saudi J Gastroenterol.)Tj /T1_0 1 Tf [( 2020;26\(1\):4\22612.)5( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4103/sjg.SJG_213_19)Tj 0 0 0 1 k /GS1 gs 0.074 Tw -1.847 -1.25 Td (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)10(or)-32(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M, S)-16(hek)-17(ar)-32(chizadeh)]TJ /Span<>> BDC ( )Tj EMC [(M, F)20(ar)-16(manar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biofeedba)-17(ck )]TJ 0.06 Tw -1.796 -1.25 Td [(ef)-56(f)-28(ica)-17(cy t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(im)10(p)25(r)-32(ove cl)-30.9(inical sym)10(pt)17(oms and end)-15.9(oscopic signs of)]TJ /Span<>> BDC ( )Tj EMC [(sol)-30.9(i)]TJ 0 Tw (-)Tj 0.306 Tw T* [(t)15(ar)-24(y r)-24(ec)-15.9(t)15(al ul)16(cer syndr)-31.9(ome. )]TJ /T1_1 1 Tf [(Eur J T)56(ransl Myol)]TJ /T1_0 1 Tf (. 2018;28\(1\):7327. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.4081/ejtm.2018.7327)Tj 0 0 0 1 k /GS1 gs 0.181 Tw -1.847 -1.25 Td (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\205\024\n\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\210.\224., \215\024\030\016\007\017\027)Tj /Span<>> BDC ( )Tj EMC (\206.\200., \204\024\030\024\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\006\036\027\022\026 )Tj 0.012 Tc 0.455 Tw -1.796 -1.25 Td (\030\036\031\035\034\021\026\021\024\r \022\024\027\f\036\030\r\026\021\ \017\r\027\024\020\024 \035\036\004\036\027\017\016 \235\031\027\022\006\ \017\024\027\026\035\034\027\t\b \030\026\f)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.35 Tw T* (\f\021\030\024\005\f\021\r \007\036\235\036\022\026\006\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\026\023\f\024\n \021\026\024\r\t\b \024\030\020\026)Tj 0 Tc 0 Tw (-)Tj 0.001 Tc -0.001 Tw T* (\027\024\r. )Tj /T1_1 1 Tf 0.35 Tw 2.37 0 Td (\004\020\023\031\f\031\b\022\007\027\024\n\020\t \203\022\016\022\031\f\031\ \b\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\204\n\024\033\027\032\022\026\027\025\023\020\f\017\025\020\t \023\027\032\ \020)Tj 0 Tc 0 Tw (-)Tj -2.37 -1.25 Td (\033\022\t)Tj /T1_0 1 Tf 0.094 Tw [(. 2021;65\(2\):44\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.25557/0031-2991.2021.02.44-52)Tj 0 0 0 1 k /GS1 gs 0.094 Tw /Span<>> BDC ( )Tj EMC (/ )Tj 0.117 Tw T* [(F)10(omenko)]TJ /Span<>> BDC ( )Tj EMC [(O.Y)35(u., P)10(or)-24(y)22(adin)]TJ /Span<>> BDC ( )Tj EMC [(G.V., M)-24(or)-32(ozov)]TJ /Span<>> BDC ( )Tj EMC [(S.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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\202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.221 Tw 10 0 0 10 42.5197 724.8299 Tm [(\n\036\032\007\031 )0.5(\024\002\255\201\n\024\n, )0.6(\022\024\035\017\004\036\f\021\r\024\n )0.5(\204\222\025-\240\221 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 17.778 0 Td (\f\022\024\030\024\f\021\034\033 )Tj 0.078 Tw -17.778 -1.218 Td [(\026\032\017\r\035\036\027\017\016 )0.5(\023\024\f\021\035\031\004\036\r\t\b \023\024\r\030\036\032\007\036\027\017\ \005 \023\030\016\n\024\005 )0.5(\022\017\001)]TJ 0 Tw (-)Tj -0.018 Tw 0 -1.218 TD (\022\017 \r\t\016\r\035\036\027\024 \027\036 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\033\007\026\035\017\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (100% \f\035\031\004\026\036\r )Tj 0.055 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (84 \007\027\036\005, \023\024\f\035\036\024\023\036\030\026\006\017\024\027\ \027\t\036 \024\f\035\024\032)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (79,2% \f\035\031\004\026\036\r)Tj /T1_2 1 Tf (.)Tj /T1_1 1 Tf 0.618 Tw 0 -1.218 TD [(\204\036\021\026\026\027\026\035\017 )0.5(\035\017\021\036\030\026\021\031\030\t, \023\030\024\r\036\007\036\027\027\ \t\005 Cheng F., )]TJ 0.079 Tw 0 -1.218 TD (Huang Z. \017)Tj /Span<>> BDC ( )Tj EMC [(L)-32(i Z. \(2020\) [76])]TJ /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.079 Tw 12.027 0 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\033 \220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.203 Tw -12.027 -1.218 Td (\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \021\024\023\017\004\036\f\022\ \024\005 \021\036\030\026\023\017\017 \204\222\025-\240\221 )Tj 0.155 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\f\035\024\032\027\t\b )0.5(\f\r\017\013\026\b, )0.5(\023\024\022\026\026\035 \r\t\f\024\022\017\005 )0.5(\023\030\024\006\036\027\021 \026)]TJ 0 Tw (-)Tj -0.007 Tw T* (\032\017\r\035\036\027\017\016. \215\024\035\027\026\016 \030\036\220\023\ \017\021\036\035\017\026\006\017\016 \027\026\030\031\032\027\024\020\024\ \024\021\r\036\030)Tj 0 Tw (-)Tj -0.087 Tw T* (\f\021\017\016 \f\r\017\013\036\r\t\b \b\024\007\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \204\222\025-\240\221 \027\026\002\ \035\033)Tj 0 Tw (-)Tj 0.13 Tw T* (\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (50,6% \023\030\024\021\017\r 34,4% \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 )Tj 0.072 Tw T* (\(\023\035\026\006\036\002\024\), \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\030\017\n\036\027\036\027\017\017 \204\222\025-\240\221\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 )Tj -0.018 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\017\027\024\r\t\n \022\035\036\036\n)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (51,6% \023\030\024\021\017\r 29,6% \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021)Tj 0 Tw (-)Tj 0.112 Tw T* (\030\024\035\034\027\024\005 \020\030\031\023\023\036 \(\021\024\035\034\ \022\024 \235\017\002\030\017\027\024\r\t\005 \022\035\036\005\). \233\235\ \235\036\022\021 )Tj 0.135 Tw T* (\021\036\030\026\023\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \204\222\025-\240\221 \026\035\035\ \024\020\036\027\027\024\020\024 \023\030\024)Tj 0 Tw (-)Tj -0.026 Tw T* (\017\f\b\024\032\007\036\027\017\016 \f\024\f\021\026\r\017\035 53,4%, \026\ \031\021\024\035\024\020\017\004\027\024\020\024)Tj /Span<>> BDC ( )Tj EMC (\227 47,3%)Tj /T1_2 1 Tf 0 Tw (.)Tj /T1_1 1 Tf 0.079 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \f\017\f\021\036\n\026\021\ \017\004\036\f\022\024\020\024 \035\017\021\036\030\026\021\031\030\027\024\ \020\024 \024\002)Tj 0 Tw (-)Tj 0.273 Tw T* (\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026, \r\t\023\024\035\027\036\027\027\ \024\020\024 \202\027\024\f\024\r\t\n)Tj /Span<>> BDC ( )Tj EMC (\230.\222. )Tj 0.292 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.042 0 Td [(\f\024\026\r\021. )0.5(\(2024\), )0.6(\023\030\017\n\036\027\036\027\017\036 )0.6(\204\222\025-\240\221 )0.5(\026\035\035\024\020\036\027\027\024\020\024 )]TJ 0.113 Tw -1.042 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\026\031\021\024\035\024\020\017\004\027\024\020\024 \023\030\024\017\f\b\ \024\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\027\024\n \035\036\004\036\027\017\017 )Tj -0.013 Tw T* (\023\036\030\017\026\027\026\035\034\027\t\b \023\024\030\026\032\036\027\ \017\005 \(\f\r\017\013\017, \016\r\t\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\027\017 )Tj -0.003 Tw T* (\025\030\024\027\026 \016\r\035\016\036\021\f\016 \220\235\235\036\022\021\ \017\r\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\t\n \n\036\021\024\007\024\n )Tj 0.197 Tw T* (\021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\n\017 \026\032\017\r\035\036\027\017\ \016 \024\021 50 \007\024)Tj /Span<>> BDC ( )Tj EMC (80% )Tj 0.127 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\036\n \f\027\017\032\036\027\017\016 \220\ \235\235\036\022\021\017\r\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036\n )Tj 0 Tw T* (\r\030\036\n\036\027\017 [77].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 286.4218 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.2 Tw 10 0 0 10 42.5197 262.0658 Tm (\221\026\022\017\n \024\002\030\026\024\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034, \024\002\013\ \036\020\024 \022\024\027)Tj 0 Tw (-)Tj -0.026 Tw T* (\f\036\027\f\031\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \222\222\242\215\025 \027\036\021, \007\026\ \027\027\t\036 \017\f\f\035\036\007\024\r\026\027\017\005 )Tj 0.234 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\017 \021\036\030\026\023\017\ \017 \021\024\020\024 \017\035\017 \017\027\024\020\024 \n\036\021\024\007\ \026 )Tj 0.185 Tw T* (\035\036\004\036\027\017\016 \r\026\030\034\017\030\031\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\017\b \023\030\036\007\036\035\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\036\007\022\024 )Tj 0.038 Tw T* [(\024\020\030\026\027\017\004\036\027\t \n\026\035\024\005 )0.5(\r\t\002\024\030\022\024\005 \023\026\006\017\036\027\021\024\r, )0.5(\024\021\f\031\021\f\021\r\017\036\n )]TJ -0.028 Tw T* [(\024\021\007\026\035\201\027\027\t\b )0.6(\030\036\031\035\034\021\026\021\024\r. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 11.27 0 Td [(\007\024\f\021\031\023\027\024\005 )0.5(\027\026\n )0.6(\035\017\021\036\030\026\021\031\030\036 )]TJ -0.053 Tw -11.27 -1.218 Td (\027\036 \024\002\027\026\030\031\032\036\027\024 \023\031\002\035\017\022\ \026\006\017\005 \024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \222\222\242\215\025 \n\036\021\024\007\024\ \n )Tj 0.246 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \026\031\021\024\ \021\030\026\027\f\023\035\026\027\021\026\006\017\017 \204\222\025-\240\ \221 \(\035\017)Tj 0 Tw (-)Tj 0.091 Tw T* (\023\024\235\017\035\017\027\020\). \212\026\027\027\t\005 \n\036\021\024\ \007 \035\036\004\036\027\017\016 \222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027)Tj 0 Tw (-)Tj -0.034 Tw T* (\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\036\027\027\036\005 \030\036\022\021\026\035\034\027\024\ \005 \017\027\r\026\020\017\027\026\006\017\036\005 1 \f\021\036\023\036\ \027\017 )Tj -0.009 Tw 23.244 57.237 Td (\017\035\017 \002\036 \027\036\201 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\026\030\031\032\027\024\020\024 \r\t\023\026\007\036\027\017\ \016 \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.146 Tw 0 -1.218 TD (\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\027\026\001\036\n\031 )0.5(\n\027\036\027\017\033, )0.5(\n\024\032\036\021 \002\t\021\034 )0.5(\023\036\030\f\023\036\022\021\017\r\027\t\n, )]TJ 0.7 Tw 0 -1.218 TD (\031\004\017\021\t\r\026\016 \b\030\024\027\017\004\036\f\022\017\005 \r\ \024\f\023\026\035\017\021\036\035\034\027\t\005 \023\030\024\006\036\f\f\ )Tj 0.189 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \026\002\024\035\036\r\026\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\022\026\026\027\027\t\005 \030\036\020\036\027\036\030\017\030\ \031\033)Tj 0 Tw (-)Tj 0 -1.218 TD (\013\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\n\031\027\024\n\024\007\031\035\017\030\031\033\013\017\005 \023\024\ \021\036\027\006\017\026\035 \204\222\025-\240\221.)Tj 0.487 Tw 0 -1.218 TD (\215\030\017\027\017\n\026\016 \r\024 \r\027\017\n\026\027\017\036 \r\024\ \n\024\032\027\024\f\021\034 \022\024\030\024\021\022\024\007\017)Tj 0 Tw (-)Tj 0.205 Tw 0 -1.218 TD [(\f\021\026\027\021\027\024\005 \026\007\030\036\f\027\024\005 )0.5(\n\017\020\030\026\006\017\017 \204\222\025-\240\221, \f\023\030\024\r\024\ \006\017\030\024)]TJ 0 Tw (-)Tj 0.303 Tw 0 -1.218 TD (\r\026\027\027\024\005 \r\t\002\030\024\f\024\n \b\036\n\024\022\017\027\ \024\r \023\024\r\030\036\032\007\201\027\027\024\005 \021\022\026\027\017\ )Tj -0.011 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\024\f\021\034 \f\023\024\f\024\002\026 \007\024\f\021\026\ \r\022\017 \022\035\036\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\026\007\026\027\027\t\005 \022\024\n)Tj 0 Tw (-)Tj 0.061 Tw T* (\023\026\030\021\n\036\027\021 \024\030\020\026\027\017\n\026, \027\026\ \017\002\024\035\036\036 \023\030\017\036\n\035\036\n\t\n \n\036\021\024\ \007\024\n )Tj -0.009 Tw T* (\r\r\036\007\036\027\017\016 \204\222\025-\240\221 \n\024\032\036\021 \002\ \t\021\034 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\005 [78]\ .)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.259 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC 6.074 0 Td [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 )0.5(\017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-18.9(\007)-4.5(\024)-4.2(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_2 1 Tf -0.008 Tc 0.267 Tw [( )0.5(\035)6.6(\022\n)-25.8(\r)-5.9(\023)-4(\031)1.6(\021)]TJ /Span<>> BDC 13.683 0 Td ( )Tj EMC 0.492 0 Td [(\003)-10.3(.)-0.7(\003)-10.3(.,)-7.9( )]TJ -0.029 Tc 0.029 Tw -20.249 -1.218 Td [(\205)-24.5(\n)-27(\032)-22.6(\022)-22.4(\030)-11(\f)-25.7(\027)-22.4(\021)-30.3(\024)-25(\n)-16.3(\022)-18.9(\235)]TJ /Span<>> BDC 5.531 0 Td ( )Tj EMC [(\205)-31.1(.\001.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -5.531 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_2 1 Tf -0.004 Tc 0.004 Tw [( \221)-2.8(\031)1.9(\b\030)0.8(\020\025\031)5.6(\021)-1.9(\020)]TJ /Span<>> BDC 17.239 0 Td ( )Tj EMC [(\036)18.8(.)3.3(\003)-6.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -17.239 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_2 1 Tf -0.004 Tc 0.004 Tw 7.694 0 Td [( \221)-2.9(\031)1.9(\b\030)0.8(\020\025\031)5.6(\021)-1.9(\020)]TJ /Span<>> BDC 4.5 0 Td ( )Tj EMC [(\036)18.8(.)3.3(\003)-6.3(.)3.9(,)-4( \205)0.5(\n)-2(\032)2.4(\022)2.6(\030)14(\f)-0.7(\027)2.6(\021)-5.2(\024\n)8.7(\022)6.1(\235)]TJ /Span<>> BDC 7.773 0 Td ( )Tj EMC [(\205)-6.1(.)25.3(\001)24.8(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -19.967 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.002 Tc -0.002 Tw [( \035)16.6(\022)9.7(\n)-15.8(\r)4.1(\023)6(\031)11.6(\021)]TJ /Span<>> BDC 10.989 0 Td ( )Tj EMC [(\003.)9.3(\003.)]TJ /T1_4 1 Tf 0 Tc 0.023 Tw -10.989 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.161 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( A)3.6(l)4.8(ek)-17.5(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.2(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, )]TJ -0.003 Tc 0.003 Tw T* [(S)2.6(e)-4.7(r)-0.7(g)-5.5(e)-5.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC [(N)10(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(S)11.8(kr)-38.3(idl)1.8(e)-7(v)-6.9(s)6.1(k)-21.5(i)-3(y)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -3.655 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -0.005 Tc 0.005 Tw -15.798 -1.218 Td [(E)14.6(le)-7.6(na)]TJ /Span<>> BDC 2.132 0 Td ( )Tj EMC [(A)-17.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(B)-4.2(o)-9.4(g)-7.5(d)-3.1(a)-5.8(n)-3.1(o)-5.6(v)5.8(a)]TJ /T1_1 1 Tf 0 Tc 0.996 Tw -3.212 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.8(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf [( E)19.6(l)4.8(e)-2.5(n)4.8(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(B)0.8(o)-4.4(g)-2.5(d)1.9(a)-0.8(n)1.9(ov)10.8(a)-14(, )]TJ -0.003 Tc 0.003 Tw T* [(S)2.6(e)-4.7(r)-0.7(g)-5.5(e)-5.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC [(N)10(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(S)11.8(kr)-38.3(idl)1.8(e)-7(v)-6.9(s)6.1(k)-21.5(i)-3(y)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -3.655 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 3.238 0 Td [( A)3.6(l)4.8(ek)-17.4(s)4.9(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.1(i)7.9(k)12.5(ut)1.4(o)-0.6(v)]TJ /T1_4 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.373 Tw T* (\207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213\035\036\027\026 \202\035\036\022\f\026\027\007\030\024\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \n\035\026\007\001\017\005 \027\026)Tj 0 Tw (-)Tj 0.543 Tw T* (\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\ \026 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\017\026\ \020)Tj 0 Tw (-)Tj 0.414 Tw T* (\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\017 \205\206\207\211 \253\203\204\230\037 \022\ \024\035\024\023\030\024\022\021\024\035\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0009-0009-1982-2200)Tj 0.331 Tw T* (\222\022\030\017\007\035\036\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\222\036\030\020\036\005 \203\017\022\024\035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030)Tj 0 Tw (-)Tj 0.422 Tw T* (\001\017\005 \027\026\031\004\027\t\005 \f\024\021\030\031\007\027\017\022\ \024\021\007\036\035\026 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 )Tj 0.24 Tw T* [(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.634 0 Td [(\b\017\030\031\030\020\017\017 )0.6(\205\206\207\211 )0.5(\253\203\204\230\037 )0.6(\022\024\035\024\023\030\024\022\021\024)]TJ 0 Tw (-)Tj 0.088 Tw -6.634 -1.218 Td (\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017; ORCID )Tj 0 Tw T* (0000-0001-8871-1891)Tj 0.003 Tw T* (\214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202\035\036\022\f\036\005 \202\035\036\022\f\026\027\007\030\024\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \030\031\022\024\r\024\007\017)Tj 0 Tw (-)Tj -0.064 Tw T* [(\021\036\035\034 )0.5(\024\021\007\036\035\026 )0.6(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 )0.6(\007\017\026\020\027\024\f\021\017\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.293 0 Td (\b\017\030\031\030\020\017\017 )Tj 0.221 Tw -18.293 -1.218 Td (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026)Tj /Span<>> BDC ( )Tj EMC (\217\024\f\f\017\017; ORCID 0000-0001-5848-4050)Tj /T1_4 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (Elena)Tj /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(Bo)-15.9(gd)42(anov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0009-1982-2200)Tj T* [(Ser)-32(ge)-11(y)]TJ /Span<>> BDC ( )Tj EMC (N.)Tj /Span<>> BDC ( )Tj EMC [(S)-15.9(kr)-37(idlevsk)-15.9(iy)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8871-1891)Tj T* [(Alek)-10(se)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(L)-31.9(ikut)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5848-4050)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 115.9299 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCE)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.25 Tw 8 0 0 8 42.5197 103.0952 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cr)-22(uveilhier)]TJ /Span<>> BDC ( )Tj EMC [(J. Ana)15.1(t)17(omie p)32(a)15(t)-12.9(hol)30(o)-16(gique du cor)-23.9(ps humain. P)40(ar)-36.9(is: )]TJ 0.023 Tw -1.296 -1.25 Td [(Baill)-30.9(ier)-24(e, Jean Bapt)-31.9(iste, 1829.)]TJ 0.35 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Madigan)Tj /Span<>> BDC ( )Tj EMC [(MR, M)-24.2(or)-10.2(son)]TJ /Span<>> BDC ( )Tj EMC [(BC. S)-16.2(ol)-31.1(i)-24.2(t)14.9(ar)-24.1(y ul)15.9(cer of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.2(he r)-24.2(ec)-16.2(tum. )]TJ /T1_2 1 Tf 0 Tw (Gut)Tj /T1_1 1 Tf (. )Tj 0.023 Tw 27.759 2.5 Td [(1969;10:871\226881. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/gut.10.11.871)Tj 0 0 0 1 k /GS1 gs 0.331 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(K.R. S)-16(ol)-31(i)-24(t)15(ar)-23.9(y r)-24(ec)-16(t)15(al ul)16(cer syndr)-32(ome. )]TJ /T1_2 1 Tf (Proc R Soc Med. )Tj /T1_1 1 Tf 0 Tw -1.296 -1.25 Td (1975;68\(1\):22\22626.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4895 56.0378 Tm (163)Tj ET endstream endobj 514 0 obj <>/Border[0 0 0]/H/N/Rect[351.461 110.391 427.436 101.095]/Subtype/Link/Type/Annot>> endobj 515 0 obj <> endobj 359 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.028 Tw 10 0 0 10 70.8661 724.8299 Tm (\021\024\035\f\021\024\005 \022\017\001\022\017, \026\022\035\033\004\026\ \033\013\017\005\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \024\023\036\030\026)Tj 0 Tw (-)Tj -0.001 Tw 0 -1.218 TD [(\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.481 0 Td [(\024\002\255\201\n\036 )0.5(\022\024\035\220\022\021\024\n\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 8.954 0 Td [(\030\036\036\022\006\017\036\005 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, )]TJ 0.18 Tw -11.435 -1.218 Td [(\021\030\026\027\f\026\027\026\035\034\027\024\005 )0.5(\007\036\n\031\022\024\026\006\017\017 \024\f\021\026\r\001\036\005\f\016\ \004\026\f\021\017 \023\030\016)]TJ 0 Tw (-)Tj 0.223 Tw T* (\n\024\005 \022\017\001\022\017 \(6\2268 \f\n\) \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \220\027\007\024\f\022\024\023\017\ \004\036)Tj 0 Tw (-)Tj 0.074 Tw T* (\f\022\017\n \r\r\036\007\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\t\005 \022\026\030\022\026\f \026\n\023\031\035\t \023\ \030\016\n\024\005 )Tj 0.035 Tw T* (\022\017\001\022\017 \f\031\n\n\026\030\027\024\005 \022\031\035\034\021\ \031\030\t \235\036\021\026\035\034\027\t\b \f\024\n\026\021\017\004\036\ \f\022\017\b )Tj 0.069 Tw 0 -1.218 TD (\022\035\036\021\024\022 \022\017\001\036\004\027\024\020\024 \220\023\017\ \021\036\035\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\036\027\b\017\n\026\035\034\027\t\b \f\021\030\024)Tj 0 Tw (-)Tj 0.037 Tw 0 -1.218 TD (\n\026\035\034\027\t\b \022\035\036\021\024\022 \020\036\023\026\021\024\ \006\017\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017)Tj 0 Tw (-)Tj 0.061 Tw T* (\r\036\027\027\t\n \r\r\036\007\036\027\017\036\n \204\222\025-\025\204 \ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\022\024\032\027\t\n \r\r\036\007\036\027\017\036\n )Tj 0.132 Tw T* (\002\017\024\035\024\020\017\004\036\f\022\017 \026\022\021\017\r\027\t\b\ \030\024\f\021\024\r\t\b \235\026\022\021\024\030\024\r \235\036\021\026\ \035\034)Tj 0 Tw (-)Tj 0.432 Tw T* [(\027\024\020\024 \023\030\024\017\f\b\024\032\007\036\027\017\016 )0.5(\007\035\016 \031\f\022\024\030\036\027\017\016 \030\036\020\036\027\036\ \030\026\006\017\017 )]TJ 0.131 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \024\f\021\ \026\r\001\036\005\f\016 \004\026\f\021\017 \023\030\016\n\024\005 \022\017\ \001)Tj 0 Tw (-)Tj 0.006 Tw 0 -1.218 TD (\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\036 \024\021\n\036\004\036\027\024, \004\021\024 \023\ \024\035\027\026\016 \220\023\017\021\036\035\017\026\006\017\016 \f\035\ \017)Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD (\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\016\n\024\005\ \022\017\001\022\017, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \220\027)Tj 0 Tw (-)Tj 0.079 Tw 0 -1.218 TD [(\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \017\f\f\035\036\007\ \024\r\026\027\017\016, )0.5(\027\026\002\035\033\007\026\035\026\f\034 \r)]TJ /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 )Tj 0.105 Tw T* (\024\021 8 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \027\036\007\036\035\034, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\017\n\024\005 \020\030\031\023\023\036 )Tj 0.328 Tw T* [(\023\026\006\017\036\027\021\024\r )0.5(\002\036 )0.6(\026\035\035\024\021\030\026\027\f\023\035\026\027\021\026\006\017\017 )0.6(\030\036\022\024\027\f\021\030\031\022\006\017\016 )]TJ -0.038 Tw T* (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\017 \023\030\024\ \017\024\001\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \024\021 9 \007\024)Tj /Span<>> BDC ( )Tj EMC (12 \n\036)Tj 0 Tw (-)Tj 0.005 Tw T* (\f\016\006\036\r. \210\f\035\024\032\027\036\027\017\005, \f\r\016\026\027\ \027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\035\035\024\021\030\026\027\f\023\035\026\027\021\026\006\017)Tj 0 Tw (-)Tj 0.021 Tw T* (\036\005 \222\025, \027\036 \027\026\002\035\033\007\026\035\024\f\034 \022\ \026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\036, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.05 Tw T* (\027\t\036 \(120 \n\036\f\016\006\036\r\) \f\030\024\022\017 [61].)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.05 Tw 13.101 0 Td (\230\f\021\024\004\027\017\022\026\n\017 \204\222\025-\025\204 )Tj 0.167 Tw -13.101 -1.218 Td [(\016\r\035\016\036\021\f\016 )0.6(\f\021\030\024\n\026 )0.5(\022\024\f\021\027\024\020\024 )0.5(\n\024\020\026. )0.5(\204\222\025-\025\204 )0.5(\r\t\007\036\035\016\033\021 )]TJ 0.221 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\021\027\024\n\024\020\024\r\t\b \026\f\023\017\030\026\021\024\ \r \020\030\036\002\027\016 \023\024\007\r\007\024\001\027\024\005 )Tj 0.337 Tw T* (\022\024\f\021\017. \212\026\027\027\026\016 \024\023\036\030\026\006\017\ \016 \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \r\t\f\024\022\024\ \005 )Tj -0.022 Tw T* (\017\027\r\026\017\r\027\024\f\021\034\033, \030\017\f\022\024\n \024\f\ \035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\t\n \022\024\035\017\004\036)Tj 0 Tw (-)Tj 0.014 Tw T* (\f\021\r\024\n, \023\024\035\031\004\026\036\n\t\b \204\222\025-\025\204\ \(\r \023\024\023\031\035\016\006\017\017 \022\026\030\017\024\006\017\021\ \024\r )Tj -0.02 Tw T* (\022\024\f\021\027\024\020\024 \n\024\020\026 \204\222\025-\025\204 \f\024\ \f\021\026\r\035\016\033\021 0,001\2260,01%\), \004\021\024 )Tj -0.005 Tw T* (\026\004\026\f\021\031\033 \021\030\036\002\031\036\021 \023\024\r\021\024\ \030\027\024\020\024 \026\002\024\030\026 \022\024\f\021\027\024\n\024\ \020\024\r\t\b )Tj -0.023 Tw T* [(\026\f\023\017\030\026\021\024\r )0.5(\017\035\017 )0.6(\022\031\035\034\021\017\r\017\030\024\r\026\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 14.256 0 Td [(\030\026\n\027\024\032\036\027\017\016 )0.6(\204\222\025-)]TJ 0.206 Tw -14.256 -1.218 Td (\025\204 \r)Tj /Span<>> BDC ( )Tj EMC (\035\026\002\024\030\026\021\024\030\027\t\b \031\f\035\024\r\017\016\b.\ \233\021\024 \016\r\035\016\036\021\f\016 \r\036\f\034\n\026 )Tj 0.154 Tw T* (\f\035\024\032\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\021\036\030\017\026\035\034\027\024 \026\021\030\026\021\027\024\ \005 \026\007\026\004\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 )Tj 0.07 Tw T* (\021\024\020\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\035\035\024\020\036\027\027\024\005 \021\030\026\027\f\023\035\026\027\ \021\026\006\017\017 \021\030\036\002\031\036\021\f\016 \023\024\007)Tj 0 Tw (-)Tj T* (\002\024\030 \017\007\036\027\021\017\004\027\024\020\024 \023\024)Tj /Span<>> BDC ( )Tj EMC [(HL)-34.8(A \007\024\027\024\030\026 [62].)]TJ 0.16 Tw T* (\202\035\034\021\036\030\027\026\021\017\r\027\t\n \017\f\021\024\004\027\ \017\022\024\n \204\222\025 \016\r\035\016\036\021\f\016 \023\024\007\022\ \024\032)Tj 0 Tw (-)Tj 0.316 Tw T* [(\027\026\016 )0.5(\032\017\030\024\r\026\016 )0.6(\021\022\026\027\034 )0.5(\(\240\221\). )0.5(\025\026\030\021\t )0.6(\220\022\f\023\030\036\f\f\017\030\031\036\n\t\b )]TJ 0.196 Tw T* [(\020\036\027\024\r )0.5(\204\222\025 )0.6(\032\017\030\024\r\024\020\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.269 0 Td [(\022\024\f\021\027\024\n\024\020\024\r\024\020\024 )0.6(\023\030\024\017\f\b\024\032)]TJ 0 Tw (-)Tj 0.23 Tw -10.269 -1.218 Td (\007\036\027\017\016 \023\030\026\022\021\017\004\036\f\022\017 \017\007\ \036\027\021\017\004\027\t [63]. \204\222\025 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\030\024)Tj 0 Tw (-)Tj 0.083 Tw T* (\r\024\005 \021\022\026\027\017 \(\204\222\025-\240\221\) \r\023\036\030\ \r\t\036 \002\t\035\017 \r\t\007\036\035\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\b\026)Tj 0 Tw (-)Tj 0.238 Tw T* (\030\026\022\021\036\030\017\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC [(2001 \020\024\007\031 Z)20(uk P.A. \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [64])Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.013 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\027\024\f\021\017 \022)Tj /Span<>> BDC ( )Tj EMC [(\007\017\235\235\036\030\036\027\006\017\030\024\r\022\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b )0.5(\027\026)]TJ 0 Tw (-)Tj 0.07 Tw T* [(\023\030\026\r\035\036\027\017\016\b )0.5(\(\220\022\021\024\007\036\030\n\026\035\034\027\024\n, \220\027\021\024\ \007\036\030\n\026\035\034\027\024\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj T* (\024\007\036\030\n\026\035\034\027\024\n\))Tj /T1_1 1 Tf (. )Tj /T1_0 1 Tf 0.197 Tw 7.018 0 Td (\212\024\022\026\026\027\024, \004\021\024 \204\222\025-\240\221 \f\036\ \022\030\036\021\017\030\031\036\021 )Tj 0.409 Tw -7.018 -1.218 Td [(\006\017\021\024\022\017\027\024\r\t\005 )0.5(\023\030\024\235\017\035\034, )0.5(\r\022\035\033\004\026\033\013\017\005 )0.6(\026\027\020\017\024\020\036\027\027\t\036, )]TJ 0.638 Tw T* [(\026\027\021\017\024\022\f\017\007\026\027\021\027\t\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.49 0 Td [(\017\n\n\031\027\024\f\031\023\030\036\f\f\017\r\027\t\036 )0.6(\235\026\022\021\024)]TJ 0 Tw (-)Tj 0.209 Tw -9.49 -1.218 Td (\030\t, \027\036\024\002\b\024\007\017\n\t\036 \007\035\016 \017\027\007\ \031\022\006\017\017 \r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\ \t\b )Tj 0.201 Tw T* (\023\030\024\006\036\f\f\024\r [67,68]. \212\026\027\027\t\005 \022\024\n\ \023\035\036\022\f \002\017\024\035\024\020\017\004\036\f\022\017 )Tj 0.09 Tw T* [(\026\022\021\017\r\027\t\b )0.6(\r\036\013\036\f\021\r )0.5(\024\023\030\036\007\036\035\016\036\021 )0.5(\f\023\024\f\024\002\027\024\f\021\034 )0.6(\204\222\025 )0.5(\f\021\017)]TJ 0 Tw (-)Tj 0.505 Tw T* (\n\031\035\017\030\024\r\026\021\034 \027\036\024\r\026\f\022\031\035\016\ \030\017\026\006\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\017\235\036\030\026\006\017\033 )Tj -0.014 Tw T* (\022\035\036\021\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \023\024\r\030\036\032\007\036\027\017\016 [67]. \025\030\024\ \n\036 \021\024\020\024, \204\222\025-\240\221 )Tj 0.304 Tw T* (\027\036 \r\t\t\r\026\033\021 \027\036\002\035\026\020\024\023\030\017\016\ \021\027\t\b \017\n\n\031\027\027\t\b \030\036\026\022\006\017\005 )Tj 0.073 Tw T* [(\017-\026 \024\021\f\031\021\f\021\r\017\016 HL)-34.9(A-DR, \023\024\007\026\r\035\036\027\017\016 \023\030\024\035\017\235\036\ \030\026\006\017\017 )]TJ 0.212 Tw T* [(\035\017\n\235\024\006\017\021\024\r, )0.6(\017\027\020\017\002\017\030\024\r\026\027\017\016 )0.6(\f\036\022\030\036\006\017\017 )0.5(\023\030\024\r\024\f\023\026\035\017)]TJ 0 Tw (-)Tj 0.234 Tw T* [(\021\036\035\034\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.784 0 Td [(\f\021\017\n\031\035\017\030\024\r\026\027\017\016 )0.6(\023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\027\t\ \b )]TJ 0.252 Tw -4.784 -1.218 Td (\006\017\021\024\022\017\027\024\r [67,68]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \027\036\024\023\035\026\f\021\017\004\ \036\f\022\024\020\024 )Tj 0.533 Tw 23.244 64.543 Td (\023\024\021\036\027\006\017\026\035\026 \204\222\025-\240\221 \f\031\013\ \036\f\021\r\031\033\021 \023\030\024\021\017\r\024\030\036\004\017\r\t\036\ )Tj 0.163 Tw T* [(\007\026\027\027\t\036, )0.5(\023\024\022\026\t\r\026\033\013\017\036, )0.6(\004\021\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.081 0 Td [(\024\007\027\017\b )0.5(\220\022\f\023\036\030\017\n\036\027\021\026\b )]TJ 0.112 Tw -13.081 -1.218 Td (\204\222\025-\240\221 \n\024\020\031\021 \f\023\024\f\024\002\f\021\r\024\ \r\026\021\034 \030\024\f\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024)Tj 0 Tw (-)Tj 0.161 Tw T* (\r\026\027\017\033 \024\023\031\b\024\035\017, \026)Tj /Span<>> BDC ( )Tj EMC (\r \007\030\031\020\017\b, \027\026\024\002\024\030\024\021,)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\007\026\r\035\016\021\034 )Tj 0.289 Tw T* [(\030\026\r\017\021\017\036 \024\023\031\b\024\035\036\r\024\020\024 )0.5(\023\030\024\006\036\f\f\026 [69,70]. \206\035\026\r\027\t\n\017 )]TJ 0.737 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\026\n\017 \204\222\025-\240\221 \024\ \021\027\024\f\017\021\036\035\034\027\024 \204\222\025-\025\204 )Tj 0 Tw 0 -1.218 TD (\f\035\036\007\031\033\013\017\036:)Tj 0.308 Tw 0 -1.218 TD (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\207\024\035\034\001\036\036 \022\024\035\017\004\036\f\021\r\024 \023\024\ \035\031\004\026\036\n\t\b \204\222\025 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\036)Tj 0 Tw (-)Tj 0.212 Tw -1.296 -1.218 Td (\027\017\021\024\030\027\t\b \022\035\036\021\024\022 \023\030\036\007\001\ \036\f\021\r\036\027\027\017\006. \200\024 \235\030\026\022\006\017\017 \ \240\221 )Tj 0.347 Tw T* (\f\024\007\036\030\032\017\021\f\016 0,5\2262,0)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 413.5784 618.5578 Tm (6 )Tj 0.347 Tw 10 0 0 10 419.8732 615.2278 Tm (\016\007\030\024\f\024\007\036\030\032\026\013\017\b \022\035\036\021\024\ \022 )Tj -0.023 Tw -11.657 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\026\n\n \021\022\026\027\017, \204\222\025-\240\221 1\22610% \r\ )Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\024\f)Tj 0 Tw (-)Tj -0.043 Tw T* (\021\024\016\027\017\016 \023\026\006\017\036\027\021\026, \036\020\024 \ \r\024\030\026\f\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\026 \026\002\024\030\026 \n\026\021\036\030\017)Tj 0 Tw (-)Tj 0.026 Tw 0 -1.218 TD [(\026\035\026, )0.5(\021\024 )0.5(\036\f\021\034 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.169 0 Td [(100 )0.5(\020\030\026\n\n )0.5(\240\221 )0.5(\023\024\035\031\004\026\036\021\f\016 )0.6(0,5\22620)]TJ /Span<>> BDC ( )Tj EMC 13.895 0 Td (\327)Tj /Span<>> BDC ( )Tj EMC 0.754 0 Td (10)Tj 0 Tw 5.83 0 0 5.83 521.4944 582.0239 Tm (6 )Tj -0.026 Tw 10 0 0 10 303.3071 566.5158 Tm (\204\222\025-\240\221, \004\021\024 \023\030\036\r\t\001\026\036\021 \022\ \024\035\017\004\036\f\021\r\024 \023\024\035\031\004\026\036\n\t\b \204\ \222\025-)Tj 0 Tw 0 -1.218 TD (\025\204 \017)Tj /Span<>> BDC ( )Tj EMC (\025\204 \r)Tj /Span<>> BDC ( )Tj EMC (500 \030\026 [71,72].)Tj 0.323 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\035\036\021\024\004\027\t\036 \235\030\026\022\006\017\017, \r\t\007\ \036\035\036\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\240\221, \n\024\020\031\021 )Tj 0.436 Tw -1.296 -1.218 Td (\002\t\021\034 \017\f\023\024\035\034\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ \002\036 )Tj 0.113 Tw T* [(\f\021\026\007\017\017 \022\031\035\034\021\017\r\017\030\024\r\026\027\017\ \016 )0.5([73,74]. \210\021\f\031\021\f\021\r\017\036 \022\031\035\034\021\017)]TJ 0 Tw (-)Tj 0.097 Tw T* (\r\017\030\024\r\026\027\017\016 \023\030\036\007\024\021\r\030\026\013\026\ \036\021 \030\017\f\022 \r\024\027\017\022\027\024\r\036\027\017\016 \022\ \024\027)Tj 0 Tw (-)Tj 0.042 Tw T* (\021\026\n\017\027\026\006\017\017 \022\035\036\021\024\004\027\024\020\024\ \n\026\021\036\030\017\026\035\026 \023\026\021\024\020\036\027\027\024\ \005 \n\017\022\030\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\235\035\024\030\024\005, \020\036\027\036\021\017\004\036\f\022\024\005\ \021\030\026\027\f\235\024\030\n\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\027\021\026\027\027\024\005 )Tj 0 Tw T* (\007\017\235\235\036\030\036\027\006\017\030\024\r\022\017 \022\035\036\021\ \024\022 [71].)Tj -0.089 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\204\026\035\026\016 \017\027\r\026\017\r\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\005 \030\017\f\022 \030\026\r\017\021\ \017\016 )Tj 0.154 Tw -1.296 -1.218 Td (\024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\002\024\030\036 \n\026\021\036\030\017\026\035\026. \214\017\023\024\ \026\f\023\017\030\026\006\017\016 )Tj -0.011 Tw T* (\023\030\024\r\024\007\017\021\f\016 \023\024\007 \n\036\f\021\027\024\005\ \017\035\017 \017\027\235\017\035\034\021\030\026\006\017\024\027\027\024\ \005 \026\027\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\f\021\036\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\026\035\034\027\t\n \002\024\035\036\r\t\n \f\017\027\007\ \030\024\n\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f)Tj 0 Tw (-)Tj 0.016 Tw T* (\022\024\n\235\024\030\021\024\n \007\035\016 \023\026\006\017\036\027\021\ \026, \001\017\030\024\022\024 \023\030\017\n\036\027\016\036\021\f\016,\ \f\021\026\027)Tj 0 Tw (-)Tj T* (\007\026\030\021\017\017\030\024\r\026\027\026, \023\030\024\f\021\026 \ \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\027\036\027\017\017 [72].)Tj 0.321 Tw T* [(\221\036\030\026\023\036\r\021\017\004\036\f\022\026\016 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.6(\204\222\025-\240\221 )0.5(\007\024\022\026\026\027\026 )]TJ 0.188 Tw T* (\030\016\007\024\n \007\024\022\035\017\027\017\004\036\f\022\017\b \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\ \017\005 )Tj 0.16 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.867 0 Td [(\030\026\035\017\004\027\t\b )0.6(\027\026\023\030\026\r\035\036\027\017\016\b )0.6(\n\036\007\017\006\017\027\t: )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.818 0 Td (\035\036\004\036\027\017\017 )Tj 0.121 Tw -18.684 -1.218 Td [(\021\030\024\235\017\004\036\f\022\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\007\035\017\021\036\035\034\027\024 )0.5(\027\036\026\032\017\r\026\033\013\017\b )0.5(\030\026\027 \017)]TJ /Span<>> BDC ( )Tj EMC (\016\r, )Tj 0.14 Tw T* (\024\f\021\036\024\026\030\021\030\024\026\b, \022\024\027\021\031\030\027\ \t\b \007\036\235\024\030\n\026\006\017\016\b \n\016\020\022\017\b \021\022\ \026)Tj 0 Tw (-)Tj 0.144 Tw T* (\027\036\005 \035\017\006\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\035\026, \024\032\024\020\026\b, \007\036\235\036\022\021\026\b\ \023\036\030\017\235\036\030\017\004\036\f\022\017\b )Tj 0.094 Tw T* (\027\036\030\r\024\r, \f\021\030\017\022\021\031\030\036 \031\030\036\021\ \030\t, \030\026\f\f\036\016\027\027\024\n \f\022\035\036\030\024\036, \ \017\027)Tj 0 Tw (-)Tj 0.042 Tw T* (\235\026\030\022\021\036 \n\017\024\022\026\030\007\026, \017\027\f\031\035\ \034\021\026\b \030\026\035\017\004\027\024\020\024 \020\036\027\036\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\007\030. )Tj 0.211 Tw T* ([72,73]. \200)Tj /Span<>> BDC ( )Tj EMC [(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\004\036\f\022\024\ \005 )0.5(\023\030\026\022\021\017\022\036 \204\222\025-\240\221 )]TJ -0.02 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\f\023\036\b\024\n \023\030\017\n\036\027\016\033\021\f\016 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\035\031\004\036\r\t\b \016\r\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022)Tj 0 Tw (-)Tj 0.07 Tw T* (\021\024\r\026\020\017\027\026\035\034\027\t\b \f\r\017\013\026\b, \022\030\ \017\023\021\024\020\035\026\027\007\031\035\016\030\027\t\b \f\r\017\013\ \026\b, )Tj -0.001 Tw T* [(\f\035\024\032\027\t\b )0.5(\023\036\030\017\026\027\026\035\034\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\022\021\026\035\034\027\t\b \f\r\017\013\026\b )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\002\024)Tj 0 Tw (-)Tj T* (\035\036\027\017 \025\030\024\027\026 [75,76].)Tj 1.137 Tw T* [(\215\024 )0.5(\030\036\031\035\034\021\026\021\026\n )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\r\t\023\024\035\027\036\027\027\024\020\024 )]TJ 0.001 Tw T* (\221\036\030\033\001\022\024\r\024\005 \240.\230. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2019\) [75], \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \027\036)Tj 0 Tw (-)Tj 0.181 Tw T* (\023\024\f\030\036\007\f\021\r\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\b \030\036\031\035\034\021\026\021\024\ \r \035\036\004\036\027\017\016 )Tj 0.217 Tw T* (\023\024\f\021\035\031\004\036\r\t\b \023\024\r\030\036\032\007\036\027\017\ \005 \023\030\016\n\024\005 \022\017\001\022\017 \(\023\030\024\022\021\017\ \021, )Tj 0.278 Tw T* (\016\r\026, \030\036\022\021\024\r\026\020\017\027\026\035\034\027\t\005\ \f\r\017\013\) \n\036\021\024\007\024\n \n\017\022\030\024\017\027\255)Tj 0 Tw (-)Tj 0.024 Tw T* (\036\022\006\017\017 \204\222\025-\240\221 \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.024 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (33\), \023\024\035\027\026\016 \220\023\017\021\036\035\017\026\006\017\ \016 \027\026\002\035\033)Tj 0 Tw (-)Tj 0.064 Tw T* (\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (100% \f\035\031\004\026\036\r, \007\035\016 \007\024\f\021\017\032\036\027\ \017\016 \022\024\021\024\030\024\005 \023\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\021\030\036\002\024\r\026\035\024\f\034 \024\021 2 \007\024)Tj /Span<>> BDC ( )Tj EMC (5 \017\027\255\036\022\006\017\005, \f\030\024\022\017 \026\032\017\r\035\ \036\027\017\016 )Tj 0.14 Tw T* (\r\026\030\034\017\030\024\r\026\035\017 \024\021 6 \n\036\f\016\006\036\ \r \007\024)Tj /Span<>> BDC ( )Tj EMC (2 \035\036\021 \(\f\030\036\007\027\036\036 \r\030\036\n\016 )Tj 0.373 Tw T* [(\007\035\016 \026\032\017\r\035\036\027\017\016 )0.5(\023\024\f\021\035\031\004\036\r\024\005 \016\r\t )0.5(6 \n\036\f\016\006\036\r)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.083 Tw -21.11 -1.218 Td (77,5%, \007\035\016 \023\024\f\021\035\031\004\036\r\t\b \f\r\017\013\036\ \005 12 \n\036\f\016\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 63%\) )Tj 0.162 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \021\016\032\036\f\021\017 \026\ \002\024\035\036\r\026\027\017\016. \202\r\021\024\030\t \024\021)Tj 0 Tw (-)Tj 0.463 Tw T* [(\n\036\004\026\033\021, \004\021\024 \f\021\026\021\017\f\021\017\004\036\ \f\022\017 )0.5(\027\026\004\017\n\024\005 \022\024\030\030\036\035\016\006\017\017 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (162)Tj ET endstream endobj 358 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, \202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.006 Tw 10 0 0 10 42.5197 724.8299 Tm (\026\007\027\036\023\036\021\035\036\r\026\016 \030\036\022\021\024\023\ \036\022\f\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\036\030\026\006\017\016 \211\220\035\035\f\026, \030\036\022\ )Tj 0 Tw (-)Tj 0.166 Tw 0 -1.218 TD [(\021\024\023\036\022\f\017\016 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\036\022\006\017\036\005 )0.5(\021\024\035\f\021\024\005 \022\017\001\022\017, )0.5(\023\036\030\036\007\027\016\016 )0.5(\030\036)]TJ 0 Tw (-)Tj T* (\036\022\006\017\016 \023\030\016\n\024\005 \022\017\001\022\017\) [30]\ .)Tj 0.393 Tw T* (\003\026\032\017\r\035\036\027\017\036 \016\r\036\027\027\024\020\024 \007\ \036\235\036\022\021\026 \023\024\f\035\036 \b\017\030\031\030\020\017\004\ \036)Tj 0 Tw (-)Tj 0.077 Tw T* (\f\022\024\020\024 \035\036\004\036\027\017\016 \030\036\020\017\f\021\030\ \017\030\031\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\n \002\024\035\034)Tj 0 Tw (-)Tj 0.234 Tw T* (\001\017\027\f\021\r\036 \f\035\031\004\026\036\r, \024\007\027\026\022\024\ \007\024\035\020\024\f\030\024\004\027\t\036 \030\036\031\035\034\021\026\ \021\t )Tj 0.128 Tw 0 -1.218 TD (\024\f\021\026\033\021\f\016 \027\036\016\f\027\t\n\017 [46]. \217\017\f\ \022 \030\036\006\017\007\017\r\026 \030\036\022\021\026\035\034\027\024\ )Tj 0 Tw (-)Tj 0.17 Tw 0 -1.218 TD (\020\024 \023\030\024\035\026\023\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\t\b \027\026\030\031\001\ \036\027\017\005 \021\024\035\f\021\024\005 )Tj 0 Tw T* (\022\017\001\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017\ \007\024\f\021\017\020\026\036\021 30% [45,46].)Tj 0.687 Tw T* (\215\024 \030\036\031\035\034\021\026\021\026\n \030\036\021\030\024\f\023\ \036\022\021\017\r\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\ \016 )Tj 0.004 Tw T* (\200\024\005\027\024\r\026 \204.\202. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2015\) [47], \b\017\030\031\030\020\017\004\036\f\022\ \024\036 \035\036)Tj 0 Tw (-)Tj 0.044 Tw T* (\004\036\027\017\036 \(\030\036\022\021\024\f\026\022\030\024\023\036\022\ \f\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\023\036\021\035\036\r\026\016 \030\036\022\021\024\023\ \036\022)Tj 0 Tw (-)Tj 0.03 Tw 0 -1.218 TD (\f\017\016\) \030\036\022\021\026\035\034\027\024\020\024 \023\030\024\035\ \026\023\f\026 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\026\006\017\017 )Tj 0.103 Tw 0 -1.218 TD (\222\222\242\215\025 \r)Tj /Span<>> BDC ( )Tj EMC (73,9% \f\035\031\004\026\036\r \(\f\030\036\007\027\017\036 \f\030\024\022\ \017 \027\026\002\035\033\007\036\027\017\016 )Tj 0.122 Tw 0 -1.218 TD (20,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,7 \n\036\f\016\006\036\r\). \200)Tj /Span<>> BDC ( )Tj EMC [(\021\024\032\036 \r\030\036\n\016 Ihna)15(t)]TJ /Span<>> BDC ( )Tj EMC (P. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj 0.33 Tw T* ([48] \024\023\031\002\035\017\022\024\r\026\035\017 \031\f\023\036\001\027\ \024 \017\035\036\004\036\027\027\t\005 \022\035\017\027\017\004\036)Tj 0 Tw (-)Tj 0.01 Tw T* [(\f\022\017\005 \f\035\031\004\026\005 )0.5(\222\222\242\215\025 \027\026)]TJ /Span<>> BDC ( )Tj EMC 9.352 0 Td (\235\024\027\036 \f\017\027\007\030\024\n\026 \024\002\f\021\030\031\022\ \021\017\r\027\024\005 )Tj 0.077 Tw -9.352 -1.218 Td (\007\036\235\036\022\026\006\017\017 \(\030\036\022\021\024\006\036\035\036\ , \220\027\021\036\030\024\006\036\035\036, \r\027\031\021\030\036\027\027\ \017\005 \030\036\022)Tj 0 Tw (-)Tj 0.316 Tw T* (\021\026\035\034\027\t\005 \023\030\024\035\026\023\f \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\017\b\024\f\017\020\n\026\). \215\024\035\024\032\017\021\036\ \035\034\027\t\005 )Tj 0.454 Tw T* (\220\235\235\036\022\021 \002\t\035 \007\024\f\021\017\020\027\031\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\030\017\n\036\027\036\027\017\ \016 )Tj 1.471 Tw T* [(\035\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017-\026\f\f\017\ \f\021\017\030\024\r\026\027\027\024\005 )0.7(\030\036\022\021\024\023\036\022\f\017\017 )]TJ 0.315 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\027\f\026\027\026\035\034\027\024\005 \220\027\007\024\f\022\ \024\023\017\004\036\f\022\024\005 \n\017\022\030\024\b\017\030\031\030\020\ \017\017, )Tj 0.177 Tw T* (\004\021\024 \031\022\026\t\r\026\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\024\f\021\034 \022\024\n\002\017\027\017\ \030\024\r\026\027\027\t\b )Tj 0.071 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\017\b \n\036\021\024\007\024\r \ \035\036\004\036\027\017\016 \222\222\242\215\025, \r\022\035\033\004\026\ \016 \n\026)Tj 0 Tw (-)Tj 0.244 Tw T* [(\035\024\017\027\r\026\017\r\027\t\036 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\036 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026, )0.6(\024\002\036\f)]TJ /Span<>> BDC (-)Tj EMC 0.066 Tw T* (\023\036\004\017\r\026\033\013\017\036 \022\026\022 \220\235\235\036\022\ \021\017\r\027\031\033 \022\024\030\030\036\022\006\017\033 \f\017\027\007\ \030\024\n\026 )Tj 0.051 Tw T* (\024\002\f\021\030\031\022\021\017\r\027\024\005 \007\036\235\036\022\026\ \006\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\235\024\030\021\027\t\005 \b\017\030\031\030)Tj 0 Tw (-)Tj -0.046 Tw T* (\020\017\004\036\f\022\017\005 \007\024\f\021\031\023 \007\035\016 \030\026\ \007\017\022\026\035\034\027\024\005 \030\036\036\022\006\017\017 \016\ \r\t \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017.)Tj 0.212 Tw T* (\215\024 \007\026\027\027\t\n \n\036\021\026\026\027\026\035\017\026 \035\ \017\021\036\030\026\021\031\030\t \007\035\016 \024\023\030\036\007\036\ \035\036)Tj 0 Tw (-)Tj 0.13 Tw T* (\027\017\016 \220\235\235\036\022\021\017\r\027\024\f\021\017 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \ \222\222\242\215\025, )Tj 0.027 Tw T* (\r\t\023\024\035\027\036\027\027\024\020\024 Gaj F. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2024 \020.)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.027 Tw 16.225 0 Td ([46], \220\027\007\024\f\022\024)Tj 0 Tw (-)Tj 0.309 Tw -16.225 -1.218 Td (\023\017\004\036\f\022\017\005 \(\026\030\020\024\027\027\024-\023\035\026\ \n\036\027\027\026\016 \022\024\026\020\031\035\016\006\017\016)Tj /Span<>> BDC ( )Tj EMC 19.139 0 Td (+)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-)Tj 0.605 Tw -19.139 -1.218 Td (\021\036\030\026\023\017\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \030\036\022\021\026\035\034\027\024\020\ \024 \023\030\024\035\026\023\f\026\) )Tj 0.297 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\017\005 )0.6(\(\023\030\017 )0.5(\r\027\031\021\030\036\027\027\036\005 )0.6(\030\036\022\021\026\035\034\027\024\005 )0.5(\017\027)]TJ 0 Tw (-)Tj 0.243 Tw -1.048 -1.218 Td (\r\026\020\017\027\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \030\036\022\021\024\023\036\022\f\017\016 \017\035\017 \023\036\030\ \036\007\027\016\016 \030\036\036\022\006\017\016 )Tj 0.352 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\024\n \r\t\023\026\007\036\027\017\017 \023\030\ \016\n\024\005 )Tj 0.153 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC [(\227 )0.5(\030\036\036\022\006\017\016 \f\035\017\017\f\021\024\005 )0.5(\024\002\024\035\024\004\022\017 )0.5(\017\035\017 \023\030\024\022\021)]TJ /Span<>> BDC (-)Tj EMC 0.349 Tw T* [(\220\022\021\024\n\017\016\) )0.5(\n\036\021\024\007\t )0.6(\035\036\004\036\027\017\016 )0.5(\002\t\035\017 )0.6(\027\026\017\002\024\035\036\036 )0.5(\220\235\235\036\022)]TJ 0 Tw (-)Tj 0.227 Tw T* (\021\017\r\027\t\n\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \n\036\021\026\026\027\026\035\017\ \026 \024\023\030\036\007\036\035\036\027\024, )Tj 0.12 Tw T* (\004\021\024 \026\032\017\r\035\036\027\017\036 \016\r\t \027\026\002\035\ \033\007\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (74,2% \017)Tj /Span<>> BDC ( )Tj EMC (70,5% )Tj 0.36 Tw T* (\f\035\031\004\026\036\r, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\ , \004\021\024 \023\030\036\r\t\001\026\035\024 \220\235\235\036\022\021\ \t )Tj 0.091 Tw T* (\022\024\027\f\036\030\r\026\021\017\r\027\024\005 \021\036\030\026\023\017\ \017 \(\217\217 0,26, 95% CI 0,15\2260,37; )Tj 0 Tw T* (I)Tj 5.83 0 0 5.83 46.2596 204.5058 Tm (2)Tj 0.113 Tw /Span<>> BDC 10 0 0 10 49.1746 201.1758 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (88%, )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.113 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \017)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-\021\036\030\026\023\017\017 \(PP 0,39, 95% CI )Tj 0 Tw -0.665 -1.218 Td (0,27\2260,52; I)Tj 5.83 0 0 5.83 90.9593 192.3278 Tm ( 2)Tj /Span<>> BDC 10 0 0 10 95.2326 188.9978 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (57%, )Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\))Tj /T1_2 1 Tf (.)Tj /T1_1 1 Tf 0.004 Tc 0.208 Tw -5.271 -1.218 Td [(\217\026\027\024\024\002\030\026\017\036 )0.5(\023\024\007\b\024\007\024\r )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 11.582 0 Td [(\035\036\004\036\027\017\033 )0.5(\222\222\242\215\025 \024\021\030\026\032\026)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.269 Tw -11.582 -1.218 Td [(\036\021 \027\026\035\017\004\017\036 \022\026\022 \002\024\035\034\001\024\ \020\024 \022\024\035\017\004\036\f\021\r\026 \027\036\030\036\001\036\027\ \027\t\b)4.1( )]TJ 0.358 Tw T* (\r\024\023\030\024\f\024\r, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\031\026\035\034\027\024\f\021\034 \007\026\035\034\027\036\005\ \001\017\b \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.331 Tw T* (\007\024\r\026\027\017\005, \r\022\035\033\004\026\016 \023\030\017\n\036\ \027\036\027\017\036 \022\035\036\021\024\004\027\t\b \002\017\024\021\036\ \b)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.254 Tw T* (\027\024\035\024\020\017\005, \022\024\021\024\030\t\036 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\024\r\030\036\n\036\027\027\024\n \220\021\026\023\036 \030\026\r\017\ \021\017\016)4.1( )]TJ 0.327 Tw T* (\030\036\020\036\027\036\030\026\021\017\r\027\024\005 \n\036\007\017\006\ \017\027\t \017\n\036\033\021 \r\t\f\024\022\017\005 \023\024\021\036\027\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.049 Tw T* (\006\017\026\035 \023\030\017\n\036\027\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\036\021\024\n \r\024\n\024\032\027\024\f\021\036\005 \f\021\r\024\ \035\024\r\t\b)4( )]TJ 0.033 Tw T* [(\022\035\036\021\024\022 )0.5(\(\222\025\) )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.836 0 Td [(\r\024\f\f\021\026\027\024\r\035\036\027\017\017 \023\024\r\030\036\032\007\ \036\027\027\t\b )0.5(\021\022\026\027\036\005)4( )]TJ 0 Tw -5.836 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC ([49].)Tj ET 0 0 0 1 K 0.5 w q 1 0 0 1 274.9606 723.83 cm 0 0 m 221.102 0 l S Q q 1 0 0 1 274.9606 711.652 cm 0 0 m 27.64 0 l S Q BT /T1_3 1 Tf 0 Tc -0.029 Tw 10 0 0 10 274.9606 724.8299 Tm [(\200\r\006\217\212\r\220\003\t\013 \220\f\r\003\002\201\b\013\216 )0.5(\206\t\002\003\r\216\b\002\f\002\n\t\005 )]TJ /Span<>> BDC ( )Tj EMC (\f\r\201\r\b\t\t )Tj 0 Tw T* (\255\255\223\200\021)Tj /T1_1 1 Tf 0.621 Tw T* (\222\025 \023\030\036\007\f\021\026\r\035\016\033\021 \f\024\002\024\005\ \027\036\007\017\235\235\036\030\036\027\006\017\030\024\r\026\027\027\t\ \036 )Tj 0.25 Tw T* (\022\035\036\021\022\017, \030\026\f\023\024\035\026\020\026\033\013\017\ \036\f\016 \023\030\026\022\021\017\004\036\f\022\017 \r\024 \r\f\036\b \ \024\030)Tj 0 Tw (-)Tj 0.101 Tw T* (\020\026\027\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \004\036\035\024\r\036\022\026 [50,51]. \025)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\n\031 \r\030\036)Tj 0 Tw (-)Tj 0.334 Tw T* (\n\036\027\017 \024\023\017\f\026\027\t \n\036\036\027\b\017\n\026\035\034\ \027\t\036, \027\036\005\030\026\035\034\027\t\036, \n\017\024)Tj /Span<>> BDC (-)Tj EMC 0.351 Tw 0 -1.218 TD (\020\036\027\027\t\036, \023\026\027\022\030\036\026\021\017\004\036\f\022\ \017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 \021\017\023\t \222\025 [52].)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.21 Tw 0 -1.218 TD (\206\035\026\r\027\t\n\017 \002\017\024\035\024\020\017\004\036\f\022\017\ \n\017 \f\r\024\005\f\021\r\026\n\017 \222\025 \016\r\035\016\036\021\f\016\ )Tj 0.502 Tw T* (\023\030\024\016\r\035\036\027\017\036 \001\017\030\024\022\024\020\024 \ \007\017\235\235\036\030\036\027\006\017\030\024\r\024\004\027\024\020\024\ \023\024)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\036\027\006\017\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \f\r\024\036\005 \022\024\n\023\036\021\036\ \027\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002)Tj 0 Tw (-)Tj 0.25 Tw T* (\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\024\002\027\024\r\035\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\036\n \220\021\024\020\024 \023\024)Tj 0 Tw (-)Tj 0.569 Tw T* [(\021\036\027\006\017\026\035\026 )0.6([50,53,54]. )0.5(\205\026\022\021\024\030\026\n\017, )0.6(\024\023\030\036\007\036\035\016\033\013\017\n\017 )]TJ 0.028 Tw 0 -1.218 TD (\031\027\017\022\026\035\034\027\024\f\021\034 \222\025, \016\r\035\016\033\ \021\f\016: \017\002\t\021\024\022 \n\217\203\025 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 )Tj 0.179 Tw 0 -1.218 TD (\021\036\035\024\n\036\030\026\027\024\005 \026\022\021\017\r\027\024\f\ \021\017, \021\024 \036\f\021\034 \022\024\027\006\t \017\b \b\030\024\n\ \024)Tj 0 Tw (-)Tj 0.038 Tw 0 -1.218 TD (\f\024\n \027\026\007\f\021\030\026\017\r\026\033\021\f\016, \220\021\017\ \022\035\036\021\022\017 \f\023\024\f\024\002\027\t \023\030\024\b\024\007\ \017\021\034 )Tj 0.445 Tw T* (\023\024\021\036\027\006\017\026\035\034\027\024 \002\036\f\022\024\027\036\ \004\027\024\036 \022\024\035\017\004\036\f\021\r\024 \022\035\036\021\024\ \004\027\t\b )Tj 0.16 Tw T* (\007\036\035\036\027\017\005, \024\027\017 \002\036\f\f\n\036\030\021\027\ \t [50,55]. \222\025 \n\024\032\027\024 \030\026\007\036)Tj 0 Tw (-)Tj 0.151 Tw T* [(\035\017\021\034 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\030\017 )0.5(\024\f\027\024\r\027\t\036 )0.5(\020\030\031\023\023\t )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\026\r\017\f\017\n\024\f\021\017 )0.5(\024\021 \017\f)]TJ 0 Tw (-)Tj 0.266 Tw T* (\021\024\004\027\017\022\026 \017\b \023\024\035\031\004\036\027\017\016\ : \220\n\002\030\017\024\027\026\035\034\027\t\036, \235\036\021\026\035\ \034\027\t\036 )Tj 0.394 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\027\026\021\026\035\034\027\t\036 \(\222\025 \r\030\024\f\ \035\024\020\024 \024\030\020\026\027\017\n\026\))Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 20.074 0 Td ([51].)Tj /T1_2 1 Tf ( )Tj /T1_1 1 Tf 0.076 Tw -20.074 -1.218 Td [(\210\021\022\030\t\021\017\036 \020\036\n\024\023\024\220\021\017\004\036\ \f\022\017\b )0.5(\222\025 \(\n\031\035\034\021\017\023\024\021\036\027\021\027\t\036 )0.5(\n\036)]TJ 0 Tw (-)Tj 0.246 Tw T* [(\036\027\b\017\n\026\035\034\027\t\036 )0.6(\f\021\030\024\n\026\035\034\027\t\036 )0.6(\022\035\036\021\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 16.422 0 Td [(\022\024\f\021\027\024\n )0.5(\n\024)]TJ 0 Tw (-)Tj 0.155 Tw -16.422 -1.218 Td (\020\036)Tj /Span<>> BDC ( )Tj EMC (\227 \204\222\025-\025\204\) \016\r\035\016\036\021\f\016 \027\026\004\026\ \035\024\n \017\f\021\024\030\017\017 \017\031\004\036\027\017\016 )Tj 0.14 Tw T* (\030\036\020\017\024\027\026\030\027\t\b \222\025 \r\030\024\f\035\024\020\ \024 \024\030\020\026\027\017\n\026 [50]. \204\222\025-\025\204 )Tj 0.225 Tw T* (\r\023\036\030\r\t\036 \002\t\035\017 \017\007\036\027\021\017\235\017\006\ \017\030\024\r\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\b\026\030\026\022\021\036\030\017\024)Tj 0 Tw (-)Tj 0.067 Tw T* (\r\026\027\t \030\024\f\f\017\005\f\022\017\n \031\004\201\027\t\n \205\030\ \017\007\036\027\001\021\036\005\027\024\n)Tj /Span<>> BDC ( )Tj EMC (\202.\242. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.281 Tw T* (\026\r\021. [56]. \200\t\007\036\035\036\027\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\021\027\024\020\024 \n\024\020\026 \204\222\025-\025\204 )Tj 0.297 Tw T* [(\023\030\024\035\017\235\036\030\017\030\031\033\021 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n )0.5(\007\017\f\022\030\036\021\027\t\b \026\007)]TJ 0 Tw (-)Tj 0.512 Tw T* (\020\036\017\r\027\t\b \022\024\035\024\027\017\005 \235\017\002\030\024\ \002\035\026\f\021\024\023\024\007\024\002\027\t\b \022\035\036\021\024\022\ . )Tj 0.204 Tw T* [(\025\026\032\007\026\016 )0.5(\022\024\035\024\027\017\016 )0.6(\024\002\030\026\031\036\021\f\016 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 13.782 0 Td [(\f\004\201\021 )0.5(\023\030\024\035\017\235\036\030\026\006\017\017 )]TJ 0.115 Tw -13.782 -1.218 Td [(\036\007\017\027\017\004\027\024\005 )0.6(\022\035\036\021\022\017-\023\030\036\007\001\036\f\021\r\036\027\027\017\ \006\t. )0.6(\025\024\035\024\027\017\017 )0.5(\204\222\025-)]TJ 0.256 Tw T* (\025\204 \024\007\027\024\r\030\036\n\036\027\027\024 \220\022\f\023\030\ \036\f\f\017\030\031\033\021 \021\030\026\027\f\022\030\017\023\021\t \007\ \035\016 )Tj 0.113 Tw T* (\030\026\035\017\004\027\t\b \035\017\027\017\005 \n\036\036\027\b\017\ \n\026\035\034\027\t\b \022\035\036\021\024\022, \n\217\203\025 \220\027\ )Tj 0 Tw (-)Tj -0.046 Tw T* [(\007\024\021\036\035\017\026\035\034\027\024\005, )0.6(\220\023\017\021\036\035\017\026\035\034\027\024\005, )0.5(\027\036\005\030\026\035\034\027\024\005 )0.6(\022\035\036\021\024\004\027\t\b )]TJ 0.204 Tw T* (\035\017\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \030\026\035\017\004\027\t\036 \002\017\024\n\024\035\ \036\022\031\035\t, \031\004\026\f\021\r\031\033)Tj 0 Tw (-)Tj 0.168 Tw T* (\013\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\017 \030\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\036 \027\036\005\030\024\021\030\024\235\027\ \t\036 )Tj 0.257 Tw T* (\235\026\022\021\024\030\t, \004\021\024 \024\023\030\036\007\036\035\016\ \036\021, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \002\024\035\034\001\017\027\f\021\r\026 )Tj 0.109 Tw T* [(\017\f\f\035\036\007\024\r\026\021\036\035\036\005, )0.6(\n\031\035\034\021\017\023\024\021\036\027\021\027\024\f\021\034 )0.5(\204\222\025-\025\204 )0.5([57,58].)]TJ /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf -0.044 Tw T* (\204\222\025-\025\204 \220\022\f\023\030\036\f\f\017\030\031\033\021 \030\ \026\035\017\004\027\t\036 \030\036\006\036\023\021\024\030\t \007\035\016\ \030\024)Tj 0 Tw (-)Tj 0.048 Tw T* (\f\021\024\r\t\b \235\026\022\021\024\030\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\006\017\021\024\022\017\027\024\r, \004\021\024 \007\026\201\021 \r\024\ \n\024\032\027\024\f\021\034 )Tj 0.393 Tw T* [(\007\035\016 )0.5(\023\024\035\031\004\036\027\017\016 )0.6(\017\n\017 )0.5(\017\027\007\031\022\021\017\r\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.426 0 Td (\030\036\020\031\035\016\021\024\030\027\t\b )Tj 0.112 Tw -16.426 -1.218 Td (\f\017\020\027\026\035\024\r \024\021 \024\022\030\031\032\026\033\013\017\ \b \022\035\036\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \026\031\021\024\022\030\017\027\027\024\n\031 )Tj 0.057 Tw T* [(\n\036\b\026\027\017\n\031. )0.6(\025\030\024\n\036 )0.5(\021\024\020\024, )0.5(\204\222\025-\025\204 )0.5(\f\017\027\021\036\017\030\031\033\021 )0.6(\022\024\n\023\024)]TJ 0 Tw (-)Tj 0.173 Tw T* (\027\036\027\021\t \r\027\036\022\035\036\021\024\004\027\024\020\024 \n\ \026\021\030\017\022\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\f\023\036\004\017\r\026\033\021 \036\020\024 )Tj 0.038 Tw T* (\f\021\030\031\022\021\031\030\017\026\006\017\033. \212\024\022\026\026\ \027\024 \023\035\026\f\021\017\004\027\024\036 \023\024\r\036\007\036\027\ \017\036 \222\025 )Tj 0.143 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\017\n\t\b \023\030\024\006\036\f\f\026\b \220\023\017\ \021\036\035\017\026\035\034\027\024-\n\036\036\027\b\017\n\026\035\034\ )Tj 0 Tw (-)Tj -0.034 Tw T* (\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\036\027\b\017\n\026\035\034\027\024-\220\023\017\021\036\035\017\ \026\035\034\027\024\005 \021\030\026\027\f\235\024\030\n\026\006\017\017\ )Tj 0.123 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \023\026\021\024\035\024\020\017\004\036\ \f\022\017\b \023\030\024\006\036\f\f\026\b \r\024 \r\030\024\f)Tj 0 Tw (-)Tj 0.155 Tw T* (\035\024\n \024\030\020\026\027\017\n\036, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\024\r\035\036\004\036\027\017\036 \220\021\024\020\ \024 \023\030\024\006\036\f\f\026 )Tj -0.036 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\036\027\036\030\026\006\017\033 \024\030\020\026\027\024\r \ \017)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 \023\024\f\021)Tj 0 Tw (-)Tj T* (\027\026\021\026\035\034\027\024\020\024 \024\027\021\024\020\036\027\036\ \026 [59,60].)Tj 0.375 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\034\027\t\b \017\f\f\035\036\007\024\r\ \026\027\017\005 \026\035\035\024\021\030\026\027)Tj 0 Tw (-)Tj -0.084 Tw T* [(\f\023\035\026\027\021\026\006\017\017 )0.6(\022\035\036\021\024\004\027\024\020\024 )0.5(\n\026\021\036\030\017\026\035\026 )0.6(\016\r\035\016\036\021\f\016 )0.5(\027\024\r\t\005 )0.6(\n\036)]TJ 0 Tw (-)Tj 0.085 Tw T* [(\021\024\007 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016 \f\036\n\036\005\027\024\020\024 \026\007\036\ \027\024\n\026\021\024\026 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_4 1 Tf 25 0 0 25 504.6646 56.0378 Tm (161)Tj ET endstream endobj 54 0 obj 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\f\r\016\017 \(\207\210\222-\021\036\030\026\023\017\016\) \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\035\017)Tj 0 Tw (-)Tj 0.172 Tw T* (\n\t \f)Tj /Span<>> BDC ( )Tj EMC (\f\031\022\030\026\035\034\235\026\021\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\030\017\n\036\027\036\027\017\036 \004\036\035\ \024\r\036\004\036)Tj 0 Tw (-)Tj -0.006 Tw T* (\f\022\024\020\024 \235\017\002\030\017\027\026 \023\024\022\026\026\035\ \017 \031\f\023\036\001\027\024\f\021\034 \007\026\027\027\t\b \n\036\021\ \024\007\024\r )Tj 0.213 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\032\017\r\035\036\027\017\016 \016\r, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \r)Tj /Span<>> BDC ( )Tj EMC (57% \f\035\031\004\026\036\r )Tj 0.35 Tw T* [(\(\007\017\026\023\026\024\027 )0.6(41\22674%\). )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 11.597 0 Td [(\026\027\026\035\017\036 )0.6(\023\024\007\020\030\031\023\023 )0.5(\030\036\020\017)]TJ 0 Tw (-)Tj 0.055 Tw -11.597 -1.218 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/Span<>> BDC ( )Tj EMC 6.355 0 Td [(\030\036\022\021\024\026\027\026\035\034\027\024\005 )0.6(\024\002\035\026\f\021\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 10.661 0 Td [(\006\036\035\034\033 )0.6(\022\031\023\017)]TJ 0 Tw (-)Tj 0.15 Tw -17.017 -1.218 Td (\030\024\r\026\027\017\016 \030\036\022\021\026\035\034\027\024\020\024 \ \023\030\024\035\026\023\f\026, \031\r\036\035\017\004\036\027\017\016 \022\ \030\024\r\024\f)Tj 0 Tw (-)Tj 0.266 Tw T* (\027\026\002\032\036\027\017\016 \f\035\017\017\f\021\024\005 \024\002\024\ \035\024\004\022\017 \007\017\f\021\026\035\034\027\024\020\024 \024\021\ \007\036\035\026 )Tj -0.008 Tw T* [(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.009 0 Td [(\031\035\031\004\001\036\027\017\016 )0.6(\r\036\020\036\021\026\021\017\r\027\024\005 )0.5(\b\024\035\017\027\036\030\020\017)]TJ 0 Tw (-)Tj 0.061 Tw -7.009 -1.218 Td (\004\036\f\022\024\005 \017\027\027\036\030\r\026\006\017\017 \022\017\001\ 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\016\r\t\))Tj /T1_1 1 Tf (.)Tj /T1_0 1 Tf 0.046 Tw T* [(\200 )0.6(\021\024\032\036 )0.6(\r\030\036\n\016 )0.5(Gour)-36.9(iou )0.5(\222. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 11.193 0 Td [(\f\024\026\r\021. )0.6([34])]TJ /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.046 Tw 4.847 0 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.752 0 Td [(\f\r\024\036\n )0.6(\f\017\f\021\036)]TJ 0 Tw (-)Tj 0.365 Tw -16.792 -1.218 Td (\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036 \024\021\n\036\021\ \017\035\017, \004\021\024 \022\024\027\f\036\030\r\026\021\017\r\027\026\ \016 )Tj 0.009 Tw T* (\021\036\030\026\023\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-\021\036\030\026\023\017\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.229 Tw T* (\006\017\036\027\021\024\r \002\036 \030\036\022\021\026\035\034\027\024\ \020\024 \023\030\024\035\026\023\f\026 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\030\036\022\021\026\035\034\027\024\036 )Tj 0 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\036 [34].)Tj 0.173 Tw T* (\204\036\f\021\027\026\016 \021\036\030\026\023\017\016 \n\036\021\024\007\ \024\n \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \r\r\ \036\007\036)Tj 0 Tw (-)Tj 0.222 Tw T* [(\027\017\016 \023\030\036\023\026\030\026\021\026 \253P)20(ur)-33(aS)15(t)15(a)15(t\273 \(\2533D-Ma)15.1(tr)-37(ix Eur)-31.9(ope SA)35(S\273, )]TJ 0.164 Tw T* (\205\030\026\027\006\017\016)Tj /Span<>> BDC ( )Tj EMC 4.004 0 Td [(\227 )0.5(\r\027\036\022\035\036\021\024\004\027\026\016 )0.6(\n\026\021\030\017\006\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.587 0 Td (\026\n\017\027\024\022\017\f\035\024\021, )Tj ET q 1 0 0 1 303.3071 175.8199 cm 0 0 m 159.297 0 l S Q BT /T1_0 1 Tf 0.34 Tw 10 0 0 10 303.3071 724.8299 Tm (\f\026\n\024\024\030\020\026\027\017\031\033\013\026\016\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\023\021\017\007 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\007\020\036\017\r\027\024)Tj 0 Tw (-)Tj 0.209 Tw T* (\020\024 \002\026\030\034\036\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\036\f\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\022\031 \022\030\024\r\024\021\036\004\036\027\017\016\) )Tj 0.101 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\016 \016\r\036\027\027\024\020\024 \007\036\235\036\022\021\ \026 \002\t\035\026 \031\f\023\036\001\027\024 \023\030\017\n\036\027\036\ \027\026 )Tj 0.027 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n \024\023\031\002\035\017\022\024\r\026\027\027\024\n \ \027\026\002\035\033\007\036\027\017\017 \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.027 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\). \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj -0.048 Tw T* (\027\024\n \022\035\017\027\017\004\036\f\022\024\n \f\035\031\004\026\036\ \002\t\035\024 \026\030\036\020\017\f\021\030\017\030\024\r\026\027\024\ \023\024\035)Tj 0 Tw (-)Tj T* (\027\024\036 \026\032\017\r\035\036\027\017\036 \016\r\t [38].)Tj 0.018 Tc -0.016 Tw 0 -1.218 TD (\215\030\017\n\036\027\036\027\017\036 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\005 \026\023\023\035\017\022\026\006\017\017 \027\026\ )Tj /Span<>> BDC ( )Tj EMC [(\222\242\215\025)18( )]TJ 0.37 Tw 0 -1.218 TD (\235\017\002\030\017\027\024\r\024\020\024 \022\035\036\016 \r)Tj /Span<>> BDC ( )Tj EMC 10.064 0 Td [(100% )0.5(\f\035\031\004\026\036\r, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n)18( )]TJ 0.174 Tw -10.064 -1.218 Td [(Eder)-29.9(le)]TJ /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1992\) [39], \023\030\017\r\036\035\024 \022)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\024\005)18( )]TJ 0.53 Tw T* (\220\023\017\021\036\035\017\026\006\017\017 \016\r\036\027\027\024\020\ \024 \007\036\235\036\022\021\026, \024\007\027\026\022\024 \007\026\027\ )Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.377 Tw T* (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \024\020\030\026\ \027\017\004\036\027\024 \027\036\002\024\035\034\001\024\005 \f\036\030\ \017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.215 Tw T* (\036\005 \f\035\031\004\026\036\r \017)Tj /Span<>> BDC ( )Tj EMC [(\024\021\f\031\021\f\021\r\017\036\n \007\026\027\027\t\b \024\002 \024\021\ \007\026\035\201\027\027\t\b)18( )]TJ -0.018 Tw 0 -1.218 TD (\030\036\031\035\034\021\026\021\026\b.)Tj 0 Tc 0.79 Tw 0 -1.218 TD (\233\235\235\036\022\021\017\r\027\024\f\021\034 \023\030\017\n\036\027\036\ \027\017\016 \026\030\020\024\027\027\024-\023\035\026\n\036\027\027\024\ \005 )Tj 0.175 Tw 0 -1.218 TD (\022\024\026\020\031\035\016\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\036\022\f\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\024\005 \022\024\027\f\036\030\r\ \026)Tj 0 Tw (-)Tj 0.238 Tw T* (\021\017\r\027\024\005 \021\036\030\026\023\017\036\005 \(\007\017\036\021\ \026)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\207\210\222-\021\036\030\026\023\017\016\) \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\031\002\035\017)Tj 0 Tw (-)Tj 0.191 Tw T* (\022\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (2017 \017)Tj /Span<>> BDC ( )Tj EMC (2024 \020\020. \023\030\024\f\023\036\022\021\017\r\027\t\b \030\026\027\ \007\024)Tj 0 Tw (-)Tj 0.427 Tw T* (\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\ \017\016\b \022\024\035\036\002\035\036\021\f\016 \024\021 66,7 )Tj 0.649 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC [(76,3%, \020\036\n\024\f\021\026\021\017\004\036\f\022\017\005 )0.5(\220\235\235\036\022\021 \007\024\f\021\017\020\026\036\021\f\016 )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (100% \f\035\031\004\026\036\r)Tj /Span<>> BDC ( )Tj EMC ([40,41].)Tj -0.026 Tw T* (\233\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \235\024\021\024\ \002\017\024\n\024\007\031\035\016\006\017\024\027\027\026\016 \(\035\026\ \036\030\027\026\016\) )Tj 0.008 Tw T* (\021\036\030\026\023\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \024\023\031\002\035\017\022\024\r\026\027\027\024\005\ \f\036\030\017\017 \022\035\017\027\017\004\036\f\022\017\b )Tj 0.277 Tw T* (\f\035\031\004\026\036\r \002\t\035\026 \220\235\235\036\022\021\017\r\027\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r 93% \027\026\002\035\033\007\026\035\026\f\034 )Tj 0.007 Tw T* (\023\024\035\027\026\016 \220\023\017\021\036\035\017\026\006\017\016 \016\ \r \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \002\036 \r\t\023\026\007\036\027\017\ \016 )Tj T* (\023\030\016\n\024\005 \022\017\001\022\017. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \007\026\035\034\027\036\005\001\036\020\024 \027\026\ \002\035\033\007\036\027\017\016, )Tj 0.273 Tw T* (\024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\026 \016\r \027\036 \030\036\020\017\f\021\030\ \017\030\024\r\026\035\024\f\034, )Tj -0.026 Tw T* [(\024\007\027\026\022\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036 )0.6(\002\t\035\024 )0.5(\024\020\030\026\027\017\004\036\027\024 )0.6(\n\026\035\024\005 )0.5(\r\t\002\024\030)]TJ 0 Tw (-)Tj T* (\022\024\005 \023\026\006\017\036\027\021\024\r [42].)Tj 0.01 Tc -0.007 Tw T* (\215\024 \007\026\027\027\t\n Jha A.K. \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. \(2021\) [43], Ha)15(y)22(asak)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(J.)10( )]TJ 0.285 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2022\) [44], \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\036 \024\023\036\030\026\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.161 Tw T* [(\027\024\036 )0.5(\035\036\004\036\027\017\036 )0.5(\023\030\017\n\036\027\016\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.526 0 Td [(\023\024\035\017\023\024\r\017\007\027\024\005 )0.5(\235\024\030)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.61 Tw -13.526 -1.218 Td (\n\036 \222\222\242\215\025 \f)Tj /Span<>> BDC ( )Tj EMC [(\n\026\027\017\235\036\f\021\017\030\031\033\013\017\n \022\030\024\r\024\ \021\036\004\036\027\017\036\n)9.9( )]TJ 0.33 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\031\007\026\004\027\024\005 \022\024\027\f\036\030\r\026\021\017\ \r\027\024\005 \021\036\030\026\023\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.107 Tw T* (\027\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \n\031\022\024\220\022\021\024\n\017\017 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.01 Tc 0.107 Tw /Span<>> BDC 14.543 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1\) \017\035\017 \007\017\f\f\036\022)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.185 Tw -14.543 -1.218 Td (\006\017\017 \()Tj /T1_1 1 Tf 0 Tc 0 Tw (n)Tj /T1_0 1 Tf 0.01 Tc 0.185 Tw /Span<>> BDC 2.892 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4\) \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036)Tj /T1_1 1 Tf 0 Tc 0 Tw (.)Tj /T1_0 1 Tf 0.01 Tc 0.185 Tw 12.128 0 Td ( \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n)10( )]TJ 0.265 Tw -15.02 -1.218 Td [(\007\026\027\027\t\b \027\026\002\035\033\007\036\027\017\005 \024\002\026\ \220\027\007\024\f\022\024\023\017\004\036\f\022\017\b \n\036\021\024\007\ \026)10( )]TJ 0.262 Tw T* (\002\t\035\017 \220\235\235\036\022\021\017\r\027\t\n\017 \r)Tj /Span<>> BDC ( )Tj EMC [(100% \f\035\031\004\026\036\r \002\036 \030\026\027\027\017\b)10( )]TJ 0.705 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\021\007\026\035\201\027\027\t\b \023\024\f\035\036\024\023\036\030\026\ \006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005)10( )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\006\017\007\017\r\024\r)Tj /Span<>> BDC ( )Tj EMC ([43,44].)Tj 0 Tc 0.016 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \021\026\022\017\036 \220\027\ \007\024\f\022\024\023\017\004\036\f\022\017\036 \n\036\021\024\007\t \035\ \036\004\036)Tj 0 Tw (-)Tj 0.16 Tw T* (\027\017\016 \222\242\215\025, \022\026\022 \023\030\017\n\036\027\036\027\ \017\036 \235\017\002\030\017\027\024\r\024\020\024 \022\035\036\016, \023\ \030\036)Tj 0 Tw (-)Tj 0.035 Tw T* [(\023\026\030\026\021\026 \253P)20(ur)-33(aS)15(t)15.1(a)14.9(t\273 \017)]TJ /Span<>> BDC ( )Tj EMC (\026\030\020\024\027\027\024-\023\035\026\n\036\027\027\024\005 \022\024\ \026\020\031\035\016\006\017\017 )Tj 0.173 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\022\021\017\004\036\f\022\017 \024\007\017\027\026\022\024\r\ \024\005 \220\235\235\036\022\021\017\r\027\024\f\021\034\033 \023\030\017\ \n\036)Tj 0 Tw (-)Tj -0.018 Tw T* (\027\016\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \235\024\030\n\026\b \222\242\215\025 \(\023\024\035\017\023\024\ \r\017\007\027\026\016, \016\r\036\027)Tj 0 Tw (-)Tj T* (\027\026\016, \f\n\036\001\026\027\027\026\016\).)Tj T* (\216\017\030\031\030\020\017\004\036\f\022\017\036 \n\036\021\024\007\t \ \035\036\004\036\027\017\016 \222\222\242\215\025)Tj 0.195 Tw T* (\216\017\030\031\030\020\017\004\036\f\022\017\036 \n\036\021\024\007\t \ \035\036\004\036\027\017\016 \222\222\242\215\025 \027\026\023\030\026\r\ \035\036\027\t, )Tj 0.14 Tw T* [(\022\026\022 )0.5(\023\030\026\r\017\035\024, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.094 0 Td [(\022\031\023\017\030\024\r\026\027\017\036 )0.6(\030\036\022\021\026\035\034\027\024\020\024 )0.5(\023\030\024\035\026\023\f\026 )]TJ 0.143 Tw -7.094 -1.218 Td (\030\026\035\017\004\027\024\005 \f\021\036\023\036\027\017 \021\016\032\ \036\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\016\033\021\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.291 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.6(\r\f\036\b )0.5(\r\t\001\036\023\036\030\036\004\017\f\035\036\027\027\t\b )0.6(\n\036\021\024\007\024\r. )]TJ 0.263 Tw T* (\222\030\036\007\017 \b\017\030\031\030\020\017\004\036\f\022\017\b \024\ \023\036\030\026\006\017\005 \r\t\007\036\035\016\033\021 \023\030\024\n\ \036\032)Tj 0 Tw (-)Tj 0.22 Tw T* [(\027\024\f\021\027\t\036 )0.6(\(\024\023\036\030\026\006\017\016 )0.5(\212\036\035\024\030\n\026, )0.5(\202\035\034\021\n\026\005\036\030\026\) )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 19.465 0 Td (\021\030\026\027\f)Tj 0 Tw (-)Tj 0.271 Tw -19.465 -1.218 Td (\026\002\007\024\n\017\027\026\035\034\027\t\036 \(\001\024\r\027\026\016\ \030\036\022\021\024\023\036\022\f\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\036\030\026\006\017\016 )Tj 0.551 Tw T* (\003\036\030\036\027\017\027\026\226\025\033\n\n\036\035\016, \030\036\022\ \021\024 \(\022\024\035\034\023\024\) \f\026\022\030\024\023\036\022\f\017\ \016, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (160)Tj ET endstream endobj 522 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, \202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.287 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\030\024\022\021\017\021\024\n, \022\035\024\026\022\024\020\036\027\ \027\t\n \023\024\035\017\023\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\b )Tj 0 Tw 0 -1.218 TD (\f\035\031\004\026\016\b \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\030\006\017\027\024\n\024\005 [24,25,26].)Tj /T1_2 1 Tf 0.184 Tw 0 -2.436 TD [(\222\f\001\003\006\004\213\210\220\002\004\235 )0.5(\220\004\006\003\t\b\004)]TJ /T1_1 1 Tf [( \222\242\215\025 \023\030\036\007\f\021\026\r\035\036\027\026 )0.5(\031\021\024\035)]TJ 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\013\036\027\027\024\005 \f\021\036\027\022\024\005 \022\017\001\022\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\030\026\r\027\024\n\036\030\027\t\n \030\026\f\023\030\036\007\036\ )Tj 0 Tw (-)Tj 0.257 Tw T* [(\035\036\027\017\036\n )0.6(\f\035\024\201\r. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.747 0 Td [(\027\026\035\017\004\017\017 )0.6(\030\036\022\021\026\035\034\027\024\020\024 )0.5(\023\030\024\035\026\023\f\026 )]TJ 0.105 Tw -8.747 -1.218 Td (\(\r\027\031\021\030\036\027\027\016\016 \030\036\022\021\026\035\034\027\ \026\016 \017\027\r\026\020\017\027\026\006\017\016, \027\026\030\031\032\ \027\024\036 \r\t)Tj 0 Tw (-)Tj 0.405 Tw T* (\023\026\007\036\027\017\036 \023\030\016\n\024\005 \022\017\001\022\017\ \) \024\023\030\036\007\036\035\016\036\021\f\016 \031\021\024\035\013\036\ \027\017\036 )Tj 0.189 Tw T* (\f\021\036\027\022\017 \022\017\001\022\017, \023\030\036\017\n\031\013\036\ \f\021\r\036\027\027\024, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \n\t\001\036\004\027\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\020\024)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\020\024 \017\035\017 \021\024\035\034\ \022\024 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016. )Tj 0.078 Tw T* [(\214\024\022\026\035\034\027\t\036 )0.5(\017\n\036\027\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\027\036 \016\r\036\027\027\024\020\024 )0.5(\007\036\235\036\022\021\026 )0.5(\b\026)]TJ 0 Tw (-)Tj -0.049 Tw T* (\030\026\022\021\036\030\017\031\033\021\f\016 \022\026\022 \017\n\036\ \027\201\027\027\t\005 \031\004\026\f\021\024\022 \f\021\036\027\022\017\ \022\017\001\022\017 )Tj -0.058 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\017\032\036\027\027\024\005 \220\b\024\020\036\027\027\024\f\ \021\034\033 \023\024\007\f\035\017\017\f\021\024\020\024 \f\035\024\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\036\007\017\027\017\021\036\035\034\027\024\021\022\026\027\027\024\005\ \023\030\024\f\035\024\005\022\017, \021.\036. \020\030\026\027\017\006\ \t \n\036\032\007\031 )Tj 0.146 Tw 0 -1.218 TD (\f\035\024\016\n\017 \f\n\026\026\027\t. \215\024)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\013\017\027\036 \f\035\017\017)Tj 0 Tw (-)Tj 0.115 Tw T* [(\f\021\024\005 \024\002\024\035\024\004\022\017 \024\023\030\036\007\036\ \035\016\033\021\f\016 )0.5(\r\f\036 \n\026\022\030\024\f\022\024\023\017\004\036\f\022\017\036 )]TJ 0.144 Tw T* (\r\026\030\017\026\027\021\t \222\242\215\025: \f\035\017\017\f\021\t\005\ \f\035\024\005 \f\024\b\030\026\027\201\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\030\017)Tj 0 Tw (-)Tj 0.114 Tw T* (\021\036\n\026\021\024\027\024\005 \235\024\030\n\036 \(\027\026 \235\024\ \027\036 \031\021\024\035\013\036\027\017\016 \r\f\036\005 \f\021\036\027\ \022\017 )Tj 0.03 Tw T* [(\022\017\001\022\017\), )0.5(\f\024\b\030\026\027\201\027 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.323 0 Td [(\031\021\024\035\013\036\027 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.501 0 Td [(\023\024\035\017\023\024\r\017\007\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.054 0 Td (\024\021)Tj 0 Tw (-)Tj 0.25 Tw -20.878 -1.218 Td (\f\031\021\f\021\r\031\036\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\016\r\036\027\027\024\005 [27,28]. \206\035\026\r\027\t\n\017 \007\017\ \235\235\036)Tj 0 Tw (-)Tj -0.028 Tw T* (\030\036\027\006\017\026\035\034\027\t\n\017 \031\035\034\021\030\026\r\ \031\022\024\r\t\n\017 \023\030\017\027\026\022\026\n\017 \027\036\024\023\ \035\026)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\021\017\004\036\f\022\024\020\024 \023\030\024\006\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\017\020\027\017\026\006\017\017 \222\242\215\025 \016\r\035\016\ \036\021\f\016 )Tj 0.277 Tw T* (\024\021\f\031\021\f\021\r\017\036 \030\026\030\031\001\036\027\017\016\ \n\t\001\036\004\027\024\020\024 \f\035\024\016 \022\017\001\036\004\027\ \024\005 )Tj 0.176 Tw T* (\f\021\036\027\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\024\027\026\030\027\t\b \035\017\n\235\026\021\017\004\036\ \f\022\017\b )Tj 0.134 Tw T* (\031\035\026\b [27]. \204\026\035\017\020\027\017\026\006\017\016 \222\ \242\215\025, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026)Tj 0 Tw (-)Tj 0.131 Tw T* (\021\031\030\t, \r\f\021\030\036\004\026\036\021\f\016 \007\024\f\021\026\ \021\024\004\027\024 \030\036\007\022\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\021\026\r\035\036\027\026 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\036\007\017\027\017\004\027\t\b \022\035\017\027\017\004\036\f\022\017\b\ \027\026\002\035\033\007\036\027\017\016\b)Tj /Span<>> BDC ( )Tj EMC ([8,26].)Tj /T1_2 1 Tf 1.027 Tw 0 -2.436 TD (\022\r\b\003\n\r\b\002\f\002\n\t\201\r\217\220\004\235 \240\r\226\r\220\002\ \n\006\004\226\t\235 )Tj /T1_1 1 Tf 0 Tw (\023\024\r\024\035\016\036\021 )Tj 0.479 Tw 0 -1.218 TD (\007\017\026\020\027\024\f\021\017\030\024\r\026\021\034 \f\021\036\023\036\ \027\034 \024\023\031\013\036\027\017\016 \023\030\024\n\036\032\027\024\ \f\021\017, )Tj 0.035 Tw T* [(\030\026\n\036\030 \030\036\022\021\024\006\036\035\036, \027\026\035\017\ \004\017\036 )0.5(\030\036\022\021\026\035\034\027\024\005 \017\027\r\026\020\017\027\026\006\ \017\017, )]TJ 0.184 Tw T* (\f\017\020\n\024\006\036\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\f\017\027\036\030\020\017\017 \n\t\001\006 \021\026\024\r\024\ \020\024 \007\027\026 [29]. )Tj 0.118 Tw T* (\025\026\022 \007\024\023\024\035\027\017\021\036\035\034\027\t\005 \n\036\ \021\024\007 \017\f\f\035\036\007\024\r\026\027\017\016 \007\035\016 \023\ \026\006\017)Tj 0 Tw (-)Tj 0.059 Tw T* [(\036\027\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.352 0 Td [(\030\036\022\021\026\035\034\027\t\n )0.6(\023\030\024\035\026\023\f\024\n )0.5(\017\f\023\024\035\034\031\036\021\f\016 )0.6(\030\036\027\021\020\036)]TJ 0 Tw (-)Tj 0.183 Tw -3.352 -1.218 Td (\027\024\035\024\020\017\004\036\f\022\024\036 \017\f\f\035\036\007\024\r\ \026\027\017\036 \023\026\f\f\026\032\026 \002\026\030\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj 0.154 Tw T* (\f\021\024\005 \022\017\001\022\036, \030\036\031\035\034\021\026\021\t\ \022\024\021\024\030\024\020\024 \017\027\021\036\030\023\030\036\021\017\ \030\031\033\021\f\016 )Tj 0.112 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \023\024\022\026\026\021\036\035\036\005 \007\036\ \235\036\022\024\020\030\026\235\017\017, \007\035\016 \031\021\024\004\027\ \036\027\017\016 )Tj 0.091 Tw T* (\235\031\027\022\006\017\024\027\026\035\034\027\t\b \024\f\024\002\036\027\ \027\024\f\021\036\005 \021\024\035\f\021\024\005 \022\017\001\022\017 \(\ \023\030\036)Tj 0 Tw (-)Tj 0.091 Tw T* (\024\002\035\026\007\026\027\017\036 \n\036\007\035\036\027\027\024-\021\ \030\026\027\017\021\027\024\020\024 \026\023\024\030\026 \017\035\017\ \220\r\026\022\031)Tj 0 Tw (-)Tj T* (\026\021\024\030\027\t\b \027\026\030\031\001\036\027\017\005\) [30].)Tj 0.049 Tw T* (\204\217\221 \024\030\020\026\027\024\r \n\026\035\024\020\024 \021\026\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\204\217-\007\036\235\036\022\024\020\030\026\235\017\016 \023\024\r\024\ )Tj 0 Tw (-)Tj 0.141 Tw T* (\035\016\033\021 \007\017\235\235\036\030\036\027\006\017\030\024\r\026\021\ \034 \222\242\215\025 \024\021 \027\036\024\023\035\026\f\021\017\004\036\ \f\022\024\020\024 )Tj 0.087 Tw T* (\023\030\024\006\036\f\f\026 [5]. \203\036\n\026\035\024\r\026\032\027\t\ \n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \222\222\242\215\025 )Tj 0.457 Tw T* (\016\r\035\016\033\021\f\016 \235\031\027\022\006\017\024\027\026\035\034\ \027\t\036 \n\036\021\024\007\t \017\f\f\035\036\007\024\r\026\027\017\016\ . )Tj 0.147 Tw T* [(S)-16(kno)-16(os S.J. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1985\) \023\024\007\004\201\030\022\017\r\026\033\021\ , \004\021\024 \027\026\017)Tj 0 Tw (-)Tj 0.505 Tw T* (\002\024\035\036\036 \017\027\235\024\030\n\026\021\017\r\027\t\n \235\031\ \027\022\006\017\024\027\026\035\034\027\t\n \n\036\021\024\007\024\n )Tj 0.311 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \016\r\035\016\036\021\f\016 \ \026\027\024\030\036\022\021\026\035\034\027\026\016 \n\026\027\024\n\036\ \021\030\017\016 )Tj 0.158 Tw T* (\r\t\f\024\022\024\020\024 \030\026\030\036\001\036\027\017\016, \031\004\ \017\021\t\r\026\016, \004\021\024 \024\007\027\017\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f)Tj 0 Tw (-)Tj 0.101 Tw T* [(\027\024\r\027\t\b \023\026\021\024\020\036\027\036\021\017\004\036\f\022\ \017\b )0.5(\235\026\022\021\024\030\024\r \030\026\r\017\021\017\016 \222\222\242\215\ \025 )]TJ 0.447 Tw T* (\016\r\035\016\033\021\f\016 \235\031\027\022\006\017\024\027\026\035\034\ \027\t\036 \027\026\030\031\001\036\027\017\016 \007\036\235\036\022\026\ \006\017\017 )Tj 0.448 Tw T* (\017\035\017 \027\036\007\024\f\021\026\021\024\004\027\024\f\021\034 \030\ \036\022\021\024\026\027\026\035\034\027\024\005 \022\024\024\030\007\017\ \027\026\006\017\017 )Tj 0 Tw T* ([31].)Tj /T1_3 1 Tf ( )Tj /T1_1 1 Tf 0.034 Tw 2.303 0 Td (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\026 \023\026\006\017\036\027\021\024\ \r \030\036\020\017\f\021\030\017)Tj 0 Tw (-)Tj 0.281 Tw -2.303 -1.218 Td [(\030\031\036\021\f\016 )0.6(\026\007\036\022\r\026\021\027\024\036 )0.5(\(\023\030\017 )0.5(III )0.6(\021\017\023\036 )0.5(\n\026\027\024\n\036\021\030\017\004\036\f\022\017\b )]TJ 0.04 Tw T* (\023\026\021\021\036\030\027\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\007\036\022\r\026\021\027\024\036 \(\023\030\017 IV )Tj ET 0 0 0 1 K 0.5 w q 1 0 0 1 274.9606 358.4899 cm 0 0 m 166.528 0 l S Q BT /T1_1 1 Tf 0.126 Tw 10 0 0 10 274.9606 724.8299 Tm (\021\017\023\036 \n\026\027\024\n\036\021\030\017\004\036\f\022\017\b \023\ \026\021\021\036\030\027\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\031\032\017\r\026\027\017\017\) )Tj -0.02 Tw T* (\031\r\036\035\017\004\036\027\017\036 \007\026\r\035\036\027\017\016 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036, \f\024\023\030\024\r\024\032\ \007\026\033)Tj 0 Tw (-)Tj 0.038 Tw T* (\013\036\036\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\b \021\017\023\026\b \027\036\007\024\f\021\026\021\024\ \004\027\t\n \031\n\036\027\034\001\036\027\017\036\n )Tj 0.226 Tw T* [(\007\026\r\035\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\026\027\026\035\034\027\024\n )0.5(\022\026\027\026\035\036. \215\024)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n )0.5(\026\027\024)]TJ 0 Tw (-)Tj 0.138 Tw T* [(\030\036\022\021\026\035\034\027\024\005 \n\026\027\024\n\036\021\030\017\ \017 S)-16(kno)-16(os S.J. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1985\) )Tj -0.01 Tw T* [([31], M)-24(or)-37(io O. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2005\) [32] \002\t\035\024 \023\024\022\026\026\027\ \024, \004\021\024 )Tj 0.07 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \027\026\002\035\033\007\026\036\021\f\016 \007\017\ \f\f\017\027\036\030\020\017\016 \035\024\002)Tj 0 Tw (-)Tj 0.156 Tw 0 -1.218 TD (\022\024\r\024-\023\030\016\n\024\022\017\001\036\004\027\024\005 \n\t\001\ \006\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\007\024\022\f\026\035\034\027\t\n \f\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\022\030\026\013\036\027\017\036\n \026\027\026\035\034\027\024\020\024 \ \f\235\017\027\022\021\036\030\026 \r)Tj /Span<>> BDC ( )Tj EMC (25\22682% \f\035\031\004\026\036\r, )Tj 0.015 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\201\027 \235\026\022\021 \030\026\r\017\ \021\017\016 \222\222\242\215\025 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\024\030\007\017)Tj 0 Tw (-)Tj -0.052 Tw T* (\027\017\030\024\r\026\027\027\024\005 \007\036\235\036\022\026\006\017\017\ \f)Tj /Span<>> BDC ( )Tj EMC (\004\030\036\n\036\030\027\t\n \027\026\021\031\032\017\r\026\027\017\036\ \n)Tj /T1_3 1 Tf 0 Tw (.)Tj /T1_1 1 Tf ( )Tj 0.024 Tw T* (\221\026\022\032\036, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n M)-24(or)-36.9(io O. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. [32], \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.425 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\222\222\242\215\025 \030\036\020\017\f\021\030\017\030\024\r\026\035\026\ \f\034 \020\017\023\036\030\004\031\r\f\021\r\017\021\036\035\034\027\024\ \f\021\034 )Tj 0.098 Tw 0 -1.218 TD [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017, \004\021\024 )0.5(\023\030\017\r\024\007\017\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\f\021\024\016\027\027\t\n )0.5(\023\024\t\r\026\n )]TJ 0.092 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\007\036\235\036\022\026\006\017\033 \017/\017\035\017 \024\013\031\013\036\ \027\017\033 \027\036\023\024\035\027\024\020\024 \024\023\024\030\024\032\ )Tj 0 Tw (-)Tj 0.213 Tw T* (\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\016\036\021\f\016 \017\002\t\021\024\004\027\t\n\ \027\026\023\030\016\032\036\027\017\036\n \r\024 )Tj 0 Tw T* (\r\030\036\n\016 \007\036\235\036\022\026\006\017\017)Tj /T1_3 1 Tf (.)Tj /T1_4 1 Tf 0 -2.436 TD (\f\n\002\004\207 \003\n\006\n\005\007\202)Tj /T1_1 1 Tf 0.474 Tw 0 -1.218 TD (\203\026 \f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034, \023\ \024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n K)25(uck)10.1(elman)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj 0.051 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (Johnson E.K. \(2019\))Tj /T1_3 1 Tf 0 Tw ( )Tj /T1_1 1 Tf 0.051 Tw 9.383 0 Td ([33], \n\024\032\027\024 \r\t\007\036\035\017\021\034 \f\035\036\007\031\ \033)Tj 0 Tw (-)Tj 0.101 Tw -9.383 -1.218 Td (\013\017\036 \n\036\021\024\007\t \035\036\004\036\027\017\016 \222\222\242\ \215\025: \022\024\027\f\036\030\r\026\021\017\r\027\t\005 \(\n\036\f\021\ )Tj 0 Tw (-)Tj -0.015 Tw T* (\027\026\016 \021\036\030\026\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \f\r\036\004\036\005, \022\035\017\ \n, \023\036\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\f\017)Tj 0 Tw (-)Tj 0.331 Tw T* (\f\021\036\n\027\026\016 \021\036\030\026\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \021\026\002\035\036\021\017\030\ \024\r\026\027\027\t\b )Tj 0.347 Tw T* (\023\030\036\023\026\030\026\021\024\r\) \022\026\022 \n\024\027\024\021\ \036\030\026\023\017\016 \017\035\017 \022\024\n\002\017\027\017\030\024\ \r\026\027)Tj 0 Tw (-)Tj 0.113 Tw T* (\027\t\005 \022\024\027\f\036\030\r\026\021\017\r\027\t\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\036\022\026\030\f\021\r\036\ \027\027\t\b )Tj 0.15 Tw T* (\023\030\036\023\026\030\026\021\024\r \022\026\022 \n\036\f\021\027\024\ , \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\024, \235\017\017\024\021\036\030\026)Tj 0 Tw (-)Tj 0.401 Tw T* (\023\036\r\021\017\004\036\f\022\017\005 \(\207\210\222-\021\036\030\026\ \023\017\016\), \220\027\007\024\f\022\024\023\017\004\036\f\022\017\005\ \(\021\024)Tj 0 Tw (-)Tj 0.364 Tw T* (\023\017\004\036\f\022\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\036 \035\036\004\036\027\017\036\)\ , \b\017\030\031\030\020\017\004\036\f\022\017\005 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\017\030\024\r\026\027\027\t\005)Tj /T1_3 1 Tf (.)Tj /T1_1 1 Tf T* (\025\024\027\f\036\030\r\026\021\017\r\027\t\036 \n\036\021\024\007\t \035\ \036\004\036\027\017\016 \222\222\242\215\025)Tj 0.129 Tw T* (\215\024 \007\026\027\027\t\n \f\017\f\021\036\n\026\021\017\004\036\f\022\ \024\020\024 \024\002\024\030\026, \r\t\023\024\035\027\036\027\027\024\ \020\024 )Tj 0.024 Tw T* [(Gour)-36.9(iou C. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2018\) [34], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\017\f\021\036\n\026\021\017\004\036)Tj 0 Tw (-)Tj 0.037 Tw T* (\f\022\024\020\024 \024\002\024\030\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\036\021\026\026\027\026\035\017\026 Qar)-37(i Y. \017)]TJ /Span<>> BDC ( )Tj EMC [(M)-24(osl)-31(i M. \(2020\) )]TJ 0.353 Tw T* [([35], \007\035\016 )0.5(\n\036\f\021\027\024\005 \021\036\030\026\023\017\017 )0.5(\222\222\242\215\025 \023\030\017\n\036\027\016\033\021 )0.5(\f\031)]TJ 0 Tw (-)Tj 0.096 Tw T* [(\022\030\026\035\034\235\026\021, )0.6(\f\026\035\017\006\017\035\026\021\t, )0.5(\020\035\033\022\024\022\024\030\021\017\022\024\f\021\036\030\024\017\007\ \t, )0.6(\f\031\035\034)]TJ 0 Tw (-)Tj 0.084 Tw T* (\235\026\f\026\035\026\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\026\035\026\n\017\027 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \035\036\022\026\030\f\021\r\036\027\027\t\ \b )Tj 0.194 Tw T* (\235\024\030\n\026\b \(\f\r\036\004\017, \022\035\017\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\027\026\), \f\017\f\021\036\n\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 \f\031\035\034)Tj 0 Tw (-)Tj 0.247 Tw T* (\235\026\f\026\035\026\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\021\017\022\024\f\021\036\030\024\017\007\t \(\r \021\026\002\ \035\036\021\017\030\024\r\026\027\027\024\005 )Tj 0 Tw T* (\235\024\030\n\036)Tj /T1_3 1 Tf (\).)Tj /T1_1 1 Tf 0.168 Tw [( Gour)-36.9(iou C. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \024\021\n\036\004\026\033\021, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n )Tj 0.581 Tw T* (\220\235\235\036\022\021\017\r\027\024\f\021\034 \022\024\027\f\036\030\r\ \026\021\017\r\027\024\020\024 \n\036\021\024\007\026 \035\036\004\036\027\ \017\016 )Tj 0.41 Tw T* (\222\222\242\215\025 \(\f\031\035\034\235\026\f\026\035\026\017\027, \f\ \031\022\030\026\035\034\235\026\021 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\026\035\026\n\017\027\) )Tj 0.077 Tw T* (\022\024\035\036\002\035\036\021\f\016 \024\021 28 \007\024)Tj /Span<>> BDC ( )Tj EMC (80%, \024\007\027\026\022\024 \004\026\f\021\024\021\026 \030\036\006\017\ \007\017\r\024\r )Tj 0.148 Tw T* (\007\024\f\021\017\020\026\036\021 50% [34]. \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \030\026\002\024\021\026\b \024\021\n\036\004\036\027\ \024, \004\021\024 )Tj 0.292 Tw T* (\027\036\024\021\255\036\n\035\036\n\024\005 \004\026\f\021\034\033 \f\017\ \f\021\036\n\027\024\020\024 \022\024\027\f\036\030\r\026\021\017\r\027\024\ \020\024 )Tj 0.078 Tw T* (\n\036\021\024\007\026 \035\036\004\036\027\017\016 \222\222\242\215\025\ \016\r\035\016\036\021\f\016 \n\024\007\017\235\017\022\026\006\017\016\ \023\024\r\036)Tj 0 Tw (-)Tj 0.004 Tw T* (\007\036\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \007\017\036\021\026, \024\002\024\020\026\013\036\027\ \027\026\016 )0.5(\022\035\036\021\004\026\021\022\024\005 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tw (-)Tj 0.024 Tw T* (\n\036\027\036\027\017\036 \f\035\026\002\017\021\036\035\034\027\t\b \f\ \030\036\007\f\021\r, \031\r\036\035\017\004\017\r\026\033\013\017\b \024\ \002\255)Tj 0 Tw (-)Tj T* (\201\n \022\026\035\024\r\t\b \n\026\f\f [34,35].)Tj 0.109 Tw T* [(\200 \021\024\032\036 \r\030\036\n\016 Qar)-37(i Y. \017)]TJ /Span<>> BDC ( )Tj EMC [(M)-24(osl)-30.9(i M. [35] \r)]TJ /Span<>> BDC ( )Tj EMC (\f\r\024\036\n \f\017\f\021\036)Tj 0 Tw (-)Tj 0.292 Tw T* (\n\026\021\017\004\036\f\022\024\n \024\002\024\030\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\036 \024\006\036\027\022\017 \220\235\ \235\036\022)Tj 0 Tw (-)Tj 0.212 Tw T* (\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \022\024\027\f\036\030\r\026\021\ \017\r\027\024\020\024 \035\036\004\036\027\017\016 )Tj 0.167 Tw T* (\222\222\242\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\026\035\034\027\t\n \023\030\024\035\026\023\f\024\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\002\036, )Tj -0.035 Tw T* (\r\022\035\033\004\026\016 \022\024\n\002\017\027\017\030\024\r\026\027\027\ \t\005 \n\036\021\024\007)Tj /Span<>> BDC ( )Tj EMC (\227 \007\017\036\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_5 1 Tf 25 0 0 25 505.4521 56.0378 Tm (159)Tj ET endstream endobj 521 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.226 Tw 10 0 0 10 70.8661 724.8299 Tm [(\210\007\027\026\022\024, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 5.089 0 Td [(\n\027\036\027\017\033 )0.6(F)10(r)-24(eimanis)]TJ /Span<>> BDC ( )Tj EMC 8.042 0 Td [(M.G. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.231 0 Td [(\f\024\026\r\021. )0.5(\(1991\) )]TJ 0.13 Tw -16.362 -1.218 Td ([18], \031\022\026\026\r\001\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \030\026\r\017\021\017\036 \023\026\021\024\035\024\ \020\017\004\036\f\022\017\b )Tj 0.257 Tw 0 -1.218 TD [(\017\n\036\027\036\027\017\005 )0.6(\r\024\n\024\032\027\024 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.635 0 Td [(\002\036 )0.5(\030\036\022\021\026\035\034\027\024\020\024 )0.6(\023\030\024\035\026\023\f\026, )]TJ 0.27 Tw -10.635 -1.218 Td (\002\024\035\036\036 \021\024\020\024 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\022\026\n\017 \r\027\031\021\030\036\027\027\036\005\ )Tj 0.038 Tw T* (\030\036\022\021\026\035\034\027\024\005 \017\027\r\026\020\017\027\026\006\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\026\007\036\027\017\036\n \023\030\016\n\024\005 \022\017\001)Tj 0 Tw (-)Tj T* (\022\017 \021\026\022\032\036 \027\036 \r\f\036\020\007\026 \030\026\r\017\ \r\026\036\021\f\016 \222\222\242\215\025.)Tj 0.075 Tw 0 -1.218 TD (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034 \030\ \026\002\024\021\031 He)Tj /Span<>> BDC ( )Tj EMC (C.C. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2023\) )Tj -0.047 Tw 0 -1.218 TD ([19], \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \r\t\f\022\026\026\027\t \023\030\036\007\023\ \024\035\024\032\036\027\017\016, \004\021\024 \222\222\242\215\025 )Tj -0.003 Tw T* (\016\r\035\016\036\021\f\016 \026\002\024\035\036\r\026\027\017\036\n \f\ )Tj /Span<>> BDC ( )Tj EMC (\020\036\027\036\021\017\004\036\f\022\024\005 \023\030\036\007\030\026\f\ \023\024\035\024)Tj 0 Tw (-)Tj 0.074 Tw T* (\032\036\027\027\024\f\021\034\033, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \n\017\f\f\036\027\f-\n\031\021\026\006\017\016\ \020\036\027\026 )Tj /T1_1 1 Tf 0 Tw [(C)14(HEK )]TJ 0.139 Tw T* (2p. H371Y)Tj /T1_0 1 Tf ( \n\024\032\036\021 \017\020\030\026\021\034 \030\036\001\026\033\013\031\ \033 \030\024\035\034 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.018 Tw T* (\r\017\021\017\017, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \023\030\024\020\027\024\036 \026\002\024\035\036\r\026\027\017\016\ . \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n )Tj 0.271 Tw 0 -1.218 TD (\007\026\027\027\024\020\024 \030\036\021\030\024\f\023\036\022\021\017\r\ \027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \023\024\022\ \026\026\027\024, )Tj 0.144 Tw 0 -1.218 TD (\004\021\024 \n\031\021\026\006\017\016 \020\036\027\026 )Tj /T1_1 1 Tf [(C)14(HEK 2p. H371Y)]TJ /T1_0 1 Tf ( \027\036 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\022\f)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\023\030\036\f\f\017\033 \002\036\035\022\026 )Tj /T1_1 1 Tf [(C)14(HEK 2\032.)]TJ /T1_0 1 Tf ( \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\t\b, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\030\026)Tj 0 Tw (-)Tj 0.083 Tw T* (\007\017\004\036\f\022\017\b \f\035\031\004\026\016\b \222\222\242\215\025\ , \027\024 \024\027\026 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\033 )Tj /T1_1 1 Tf -0.013 Tw T* [(C)14(HEK 2\032)]TJ /T1_0 1 Tf (., \004\021\024 \024\021\030\026\032\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\030\036\f\f\017\017 \027\017\032\036\f\021\024\016\013\017\ \b )Tj 0 Tw T* (\020\036\027\024\r: )Tj /T1_1 1 Tf -0.038 Tw 2.812 0 Td [(CDC )0.5(25A)]TJ /T1_0 1 Tf [( )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 4.051 0 Td [(p-P53 )0.5(\(Ser )0.6(20\).)]TJ /T1_0 1 Tf [( )0.5(\203\026)]TJ /Span<>> BDC ( )Tj EMC 7.512 0 Td [(\024\f\027\024\r\026\027\017\017 )0.6(\030\036\031\035\034)]TJ 0 Tw (-)Tj 0.176 Tw -14.376 -1.218 Td (\021\026\021\024\r \017\n\n\031\027\024\020\017\f\021\024\b\017\n\017\004\ \036\f\022\017\b \017\f\f\035\036\007\024\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.034 Tw T* (\027\024\005 \030\026\002\024\021\036 \002\t\035\024 \023\030\024\007\036\ \n\024\027\f\021\030\017\030\024\r\026\027\024, \004\021\024 \r\026\030\017\ \026\006\017\017 )Tj 0.064 Tw T* (\031\030\024\r\027\016 \220\022\f\023\030\036\f\f\017\017 )Tj /T1_1 1 Tf (CDC 25A)Tj /T1_0 1 Tf ( \002\024\035\036\036 \027\026\004\017\021\036\035\034\027\t \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.043 Tw T* (\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\n\036\005\027\t\n \026\027\026\n\027\036\024\n \222\222\242\215\025\ , \021\024\020\007\026 \022\026\022 \017)Tj 0 Tw (-)Tj 0.158 Tw T* (\n\036\027\036\027\017\016 \031\030\024\r\027\016 \220\022\f\023\030\036\ \f\f\017\017 )Tj /T1_1 1 Tf 0 Tw (p-P53)Tj /T1_0 1 Tf 0.158 Tw ( \002\024\035\036\036 \r\t\030\026\032\036\027\t )Tj 0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\030\026\007\017\004\036\f\022\017\b \f\035\031\004\026\016\b \ \026\002\024\035\036\r\026\027\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024\032\036 \r\030\036\n\016, )Tj 0.314 Tw T* (\026\r\021\024\030\026\n\017 \024\021\n\036\004\036\027\t \024\020\030\026\ \027\017\004\036\027\017\016 \017\f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.345 Tw T* (\027\036\002\024\035\034\001\026\016 \004\017\f\035\036\027\027\024\f\021\ \034 \022\024\020\024\030\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )Tj 0.012 Tw T* (\023\026\006\017\036\027\021\024\r, \030\036\021\030\024\f\023\036\022\021\ \017\r\027\t\005 \b\026\030\026\022\021\036\030 \017\f\f\035\036\007\024\ \r\026\027\017\016, )Tj 0.079 Tw T* (\r \f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \r\t\f\022\026\026\027\026 \027\036\024\002\b\024\007\017\n\024\ \f\021\034 \023\030\024\r\036\007\036\027\017\016 )Tj 0.207 Tw T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \022\024\027\021\ \030\024\035\017\030\031\036\n\t\b \017\f\f\035\036\007\024\r\026\027\017\ \005 )Tj 0.189 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\031 \n\031\021\026\006\017\017 \020\036\027\026 )Tj /T1_1 1 Tf [(C)14(HEK 2p.H371Y)]TJ /T1_0 1 Tf ( \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \030\024\035\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\020\036\027\036\036 \222\222\242\215\025)Tj /T1_1 1 Tf (.)Tj /T1_0 1 Tf 0.049 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\017\021\036\030\026\021\031\030\t, \222\222\242\ \215\025)Tj /Span<>> BDC ( )Tj EMC (\227 \026)Tj 0 Tw (-)Tj 0.046 Tw T* (\002\024\035\036\r\026\027\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\t\n \023\026\021\024\020\036\ \027\036\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\007\024 \022\024\027)Tj 0 Tw (-)Tj T* (\006\026 \027\036\016\f\027\024\005 \220\021\017\024\035\024\020\017\036\ \005.)Tj /T1_2 1 Tf 0 -2.436 TD (\021\f\t\b\t\220\004 \t)Tj /Span<>> BDC ( )Tj EMC (\240\t\004\n\b\002\217\003\t\220\004)Tj /T1_0 1 Tf 0.412 Tw 0 -1.218 TD (\207\024\035\034\001\017\027\f\021\r\024 \026\r\021\024\030\024\r \031\022\ \026\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\030\024\004\036\027\027\031\033 )Tj 0.354 Tw T* (\007\017\026\020\027\024\f\021\017\022\031 \222\222\242\215\025; \f\030\036\ \007\027\036\036 \r\030\036\n\016 \024\021 \023\024\016\r\035\036\027\017\ \016 )Tj 0.078 Tw T* (\f\017\n\023\021\024\n\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026 \f\024\ \f\021\026\r\035\016\036\021 5 \035\036\021 )Tj 0.112 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\034\017\030\031\036\021 \024\021 3 \n\036\f\016\006\036\r \007\ \024)Tj /Span<>> BDC ( )Tj EMC (30 \035\036\021 \031)Tj /Span<>> BDC ( )Tj EMC (\r\030\024\f\035\t\b, \004\021\024 )Tj 0.305 Tw T* [(\002\024\035\034\001\036, )0.5(\004\036\n \031)]TJ /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\024\r )0.5(\007\036\021\f\022\024\020\024 )0.5(\r\024\030\026\f\021\026 \(1,2\226)]TJ 0 Tw T* (5,5)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\) [5,6,10].)Tj 0.556 Tw T* (\025\035\017\027\017\004\036\f\022\017\036 \023\030\024\016\r\035\036\027\ \017\016 \222\222\242\215\025, \r\036\f\034\n\026, \r\026\030\017\026)Tj 0 Tw (-)Tj 0.16 Tw T* (\002\036\035\034\027\t, \r\023\035\024\021\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017\b \024\021\f\031\021\f\021\r\017\016 [5,18]. \222\030\036\007\017 \024\ \002\255)Tj 0 Tw (-)Tj 0.396 Tw T* (\036\022\021\017\r\027\t\b \f\017\n\023\021\024\n\024\r \n\024\032\027\024\ \r\t\007\036\035\017\021\034 \030\036\022\021\026\035\034\027\024\036 )Tj 0.597 Tw T* (\022\030\024\r\024\021\036\004\036\027\017\036, \024\002\017\035\034\027\ \024\036 \r\t\007\036\035\036\027\017\036 \f\035\017\017, \002\024\035\034\ )Tj 0.239 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036, \024\013\031\013\036\027\017\036 \027\036\023\024\ \035\027\024\005 \007\036)Tj 0 Tw (-)Tj 0.319 Tw T* (\235\036\022\026\006\017\017, \026\023\024\030, \007\035\017\021\036\035\ \034\027\024\036 \004\030\036\n\036\030\027\024\036 \027\026\023\030\016\ \032\036)Tj 0 Tw (-)Tj 0.11 Tw T* (\027\017\036 \r\024 \r\030\036\n\016 \007\036\235\036\022\026\006\017\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\036 \r\t\023\026\007\036\027\017\036 \023\030\016\n\024\005\ )Tj 0.203 Tw T* (\022\017\001\022\017 [5,6,11].)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.203 Tw 6.906 0 Td (\253\003\024\035\024\021\t\n\273 \f\021\026\027\007\026\030\021\024\n \007\ \017\026\020\027\024\f\021\017\022\017 )Tj 0.174 Tw -6.906 -1.218 Td (\222\222\242\215\025 \016\r\035\016\036\021\f\016 \022\024\035\024\027\024\ \f\022\024\023\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\036\n \002\017\024)Tj 0 Tw (-)Tj 0.399 Tw T* (\023\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\n \017\ \f\f\035\036\007\024\r\026\027\017\036\n \n\026)Tj 0 Tw (-)Tj 0.325 Tw T* (\021\036\030\017\026\035\026. \222\030\036\007\017 \007\024\023\024\035\027\ \017\021\036\035\034\027\t\b \n\036\021\024\007\024\r \007\017\026\020\027\ \024\f)Tj 0 Tw (-)Tj 0.085 Tw T* (\021\017\022\017 \r\t\007\036\035\016\033\021 \023\026\035\034\006\036\r\ \024\036 \030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036, )Tj 0.344 Tw 23.244 64.543 Td (\030\036\022\021\024\030\024\n\026\027\024\f\022\024\023\017\033, \021\030\ \026\027\f\030\036\022\021\026\035\034\027\024\036 \031\035\034\021\030\026\ \r\031\022\024)Tj 0 Tw (-)Tj 0.252 Tw T* [(\r\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036, )0.5(\030\036\027\021\020\036\027\024\035\024\020\017\004\036\f\022\031\033 )0.6(\007\036\235\036\022\024\020\030\026)]TJ 0 Tw (-)Tj 0.241 Tw T* (\235\017\033, \n\026\027\024\n\036\021\030\017\033 \r\t\f\024\022\024\020\ \024 \030\026\030\036\001\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\020\027\017\021)Tj 0 Tw (-)Tj 0.074 Tw T* (\027\024-\030\036\024\027\026\027\f\027\031\033 \021\024\n\024\020\030\026\ \235\017\033 [5,6,7]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\006\036\r\024\n )Tj 0.378 Tw T* (\030\036\022\021\026\035\034\027\024\n \017\f\f\035\036\007\024\r\026\027\ \017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036\r )Tj 0.684 Tw T* (\024\023\030\036\007\036\035\016\036\021\f\016 \031\023\035\024\021\027\036\ \027\017\036 \017/\017\035\017 \023\026\021\024\035\024\020\017\004\036\f\ \022\026\016 )Tj 0.155 Tw 0 -1.218 TD (\023\024\007\r\017\032\027\024\f\021\034 \f\035\017\017\f\021\024\005 \024\ \002\024\035\024\004\022\017 \007\017\f\021\026\035\034\027\024\005 \004\ \026\f\021\017 )Tj -0.014 Tw 0 -1.218 TD (\(4\22610 \f\n \023\030\024\022\f\017\n\026\035\034\027\036\036 \r\027\031\ \021\030\036\027\027\036\020\024 \022\030\026\016 \026\027\026\035\034\027\ \024\020\024 )Tj 0.102 Tw T* [(\022\026\027\026\035\026\), \023\030\036\017\n\031\013\036\f\021\r\036\027\ \027\024, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \023\024\035\031\024\022\030\031\032)Tj 0 Tw (-)Tj 0.397 Tw T* [(\027\024\f\021\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\(\021\017\023\017\004\027\026\016 )0.5(\035\024\022\026\035\017\026\006\017\016 )0.6(\007\035\016 )]TJ 0.205 Tw T* (\222\222\242\215\025\), \017\035\017 \035\033\002\024\005 \007\030\031\020\ \024\005 \035\024\022\026\035\017\026\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032)Tj 0 Tw (-)Tj 0.195 Tw T* (\027\024\f\021\017; \r)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\036 \f\035\031\004\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \006\017\030\022\031\035\016\030\027\024\036 \023\024\030\026\032\036\ \027\017\036. )Tj 0.108 Tw 0 -1.218 TD (\211\023\035\024\021\027\036\027\017\036 \n\024\032\036\021 \017\n\036\021\ \034 \031\035\024\r\026\021\031\033 \017\035\017 \023\024\035\017\023\024\ \r\017\007)Tj 0 Tw (-)Tj 0.371 Tw 0 -1.218 TD (\027\031\033 \235\024\030\n\031 [5,20].)Tj /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf 0.371 Tw 8.848 0 Td (\233\027\007\024\f\022\024\023\017\004\036\f\022\017 \r\t\007\036\035\016\ \033\021 \016)Tj 0 Tw (-)Tj 0.113 Tw -8.848 -1.218 Td (\r\036\027\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\016\r\036\027\027\024\036 \023\024\030\026\032\036\027\017\036\ \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\t\030\036 \r\026\030\017\026\027\021\026 )Tj 0.081 Tw 0 -1.218 TD [(\222\242\215\025: )0.5(\220\030\017\021\036\n\026\021\024\027\t\005 )0.6(\(\26320%\), )0.5(\016\r\036\027\027\t\005 )0.6(\(\26355%\), )0.5(\023\024)]TJ 0 Tw (-)Tj 0.123 Tw T* (\035\017\023\024\r\017\007\027\t\005 \(\26324%\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\n\036\001\026\027\027\t\005 \(\2636%\). \242\r\036\027\027\t\005 )Tj -0.023 Tw T* [(\r\026\030\017\026\027\021 \b\026\030\026\022\021\036\030\017\031\036\021\ \f\016 )0.5(\027\026\035\017\004\017\036\n \016\r\036\027\027\024\020\024 \007\036\235\ \036\022)]TJ 0 Tw (-)Tj -0.013 Tw T* (\021\026 \030\026\035\017\004\027\024\005 \235\024\030\n\t \(\024\022\030\ \031\020\035\026\016, \024\r\026\035\034\027\026\016, \027\036\023\030\026\ \r\017\035\034)Tj 0 Tw (-)Tj 0.079 Tw T* (\027\026\016\), \020\035\031\002\017\027\t \(\004\026\013\036 \023\024\r\ \036\030\b\027\024\f\021\027\t\036, \027\024 \r\f\021\030\036\004\026\033\ \021\f\016 )Tj 0.181 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\017\036, \022\024\021\024\030\t\036 \027\036 \007\ \024\f\021\017\020\026\033\021 \n\t\001\036\004\027\024\020\024 \f\035\024\ \016 )Tj 0.009 Tw T* [(\f\021\036\027\022\017 )0.6(\022\017\001\022\017\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.014 0 Td [(\030\026\n\036\030\026 )0.5(\(\r )0.6(\f\030\036\007\027\036\n, )0.5(1,5\2262,0 )0.5(\f\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.731 0 Td (\007\017)Tj 0 Tw (-)Tj 0.02 Tw -20.745 -1.218 Td [(\026\n\036\021\030\036\). )0.5(\025\030\026\016 \016\r\036\027\027\024\020\024 )0.5(\007\036\235\036\022\021\026 )0.5(\n\024\020\031\021 \002\t\021\034 )0.5(\023\035\024\f\022\017)]TJ 0 Tw (-)Tj 0.097 Tw T* (\n\017, \023\035\024\f\022\024-\023\030\017\023\024\007\027\016\021\t\n\017\ \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\030\t\021\t\n\017, \026)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \016\r\t, )Tj 0.1 Tw T* (\022\026\022 \023\030\026\r\017\035\024, \030\024\r\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\030\t\021\024 \021\024\027\022\017\n \027\026\035\201\021\024\ \n \235\017)Tj 0 Tw (-)Tj 0.038 Tw T* (\002\030\017\027\026. \222\035\017\017\f\021\026\016 \024\002\024\035\024\ \004\022\026 \r\024\022\030\031\020 \016\r\t \027\036 \017\n\036\027\036\ \027\026 )Tj -0.023 Tw T* [(\017\035\017 )0.5(\020\017\023\036\030\036\n\017\030\024\r\026\027\026, )0.5(\f\024\f\031\007\017\f\021\t\005 )0.6(\030\017\f\031\027\024\022 )0.5(\f\n\026\026\027 )0.6(\017\035\017 )]TJ 0.233 Tw T* (\023\036\030\036\f\021\030\024\036\027. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\030\017\021\036\n\026\021\024\027\024\n \r\026\030\017\026\027\021\ \036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 )Tj 0.108 Tw T* (\027\036\017\n\036\027\036\027\027\024\005 \f\035\017\017\f\021\024\005\ \024\002\024\035\024\004\022\017 \r\017\031\026\035\017\017\030\031\036\ \021\f\016 )Tj 0.29 Tw T* (\035\024\022\026\035\034\027\t\005 \031\004\026\f\021\024\022 \017\027\235\ \017\035\034\021\030\026\006\017\017, \004\026\013\036 \r\f\036\020\024 \ \023\024)Tj 0 Tw (-)Tj 0.319 Tw T* (\022\030\t\021\t\005 \002\036\035\036\f\024\r\026\021\t\n, \b\024\030\024\ \001\024 \f\n\t\r\026\036\n\t\n \027\026\035\201\021\024\n )Tj 0.011 Tw T* (\235\017\002\030\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\026\020\026\033\013\017\005\f\016, \022\026\022 \023\ \030\026\r\017\035\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007)Tj 0 Tw (-)Tj 0.159 Tw T* [(\027\036\005 \023\024\035\031\024\022\030\031\032\027\024\f\021\017 )0.5(\023\030\016\n\024\005 \022\017\001\022\017. \215\024\035\017\023\024\r\017\ \007\027\t\005 )]TJ 0.244 Tw T* (\r\026\030\017\026\027\021 \b\026\030\026\022\021\036\030\017\031\036\021\ \f\016 \027\026\035\017\004\017\036\n \n\027\024\032\036\f\021\r\036\027\ \027\t\b )Tj 0.173 Tw T* (\023\024\035\017\023\024\r\017\007\027\t\b \030\026\030\026\f\021\026\027\ \017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\024\005 \024\002\024\035\024\004\022\036, )Tj 0.195 Tw T* (\f\035\017\r\026\033\013\017\b\f\016 \n\036\032\007\031 \f\024\002\024\005\ , \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \027\036\017\n\036\027\036\027\027\024\005 )Tj 0.215 Tw T* (\017\035\017 \020\017\023\036\030\036\n\017\030\024\r\026\027\027\024\005\ /\220\030\024\017\r\027\024-\r\024\f\023\026\035\036\027\027\024\005 \f\ \035\017)Tj 0 Tw (-)Tj T* (\017\f\021\024\005 \(\020\030\026\027\031\035\016\006\017\024\027\027\026\ \016 \021\022\026\027\034)Tj /T1_1 1 Tf (\))Tj /T1_0 1 Tf ( [9,20,21].)Tj /T1_2 1 Tf 0.331 Tw 0 -2.436 TD (\215\002\006\226\002\f\002\n\t\201\r\217\220\004\235 \220\004\006\003\t\b\ \004)Tj /T1_0 1 Tf ( \027\036\016\r\036\027\027\024\020\024 \r\026\030\017\026\027\021\026 \ )Tj 0.33 Tw 0 -1.218 TD (\222\242\215\025 \023\030\036\007\f\021\026\r\035\036\027\026 \020\017\023\ \036\030\021\030\024\235\017\036\005 \n\t\001\036\004\027\024\005 \023\035\ \026)Tj 0 Tw (-)Tj 0.142 Tw T* (\f\021\017\027\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\007\036\035\036\027\017\036\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\024\022\027\026, \022\024\021\024\030\t\036 \027\026\023\030\026\ \r)Tj 0 Tw (-)Tj 0.098 Tw T* (\035\016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\017\017\f\021\031\033 \024\002\024\035\024\004\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\201\n \023\030\024)Tj 0 Tw (-)Tj 0.182 Tw T* (\021\016\032\036\027\017\017 \036\201 \f\024\002\f\021\r\036\027\027\024\ \005 \023\035\026\f\021\017\027\022\017. \215\030\024\035\017\235\036\030\ \026\006\017\016 )Tj -0.038 Tw T* (\020\035\026\007\022\024\n\t\001\036\004\027\t\b \r\024\035\024\022\024\027\ \f\024\023\030\024\r\024\032\007\026\036\021\f\016 \235\017\002\030\024\ \024\n )Tj -0.019 Tw T* [(\030\026\027\024\005 )0.5(\f\021\036\023\036\027\017, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 7.49 0 Td [(\021\026\022\032\036 )0.5(\007\036\235\024\030\n\026\006\017\036\005 )0.6(\032\036\035\201. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.369 0 Td (\016)Tj 0 Tw (-)Tj 0.07 Tw -20.859 -1.218 Td (\r\036\027\027\024\n \r\026\030\017\026\027\021\036 \b\026\030\026\022\021\ \036\030\027\024 \023\030\024\035\026\002\017\030\024\r\026\027\017\036 \ \032\036\035\201 )Tj -0.01 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\235\030\026\020\n\036\027\021\024\r \f\024\002\f\021\r\036\027\027\024\005\ \023\035\026\f\021\017\027\022\017 \f\035\017\017\f\021\024\005 \024\002\ \024)Tj 0 Tw (-)Tj -0.034 Tw T* (\035\024\004\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\031\033 \024\f\027\024\r\031. \212\036\ \235\024\030\n\026\006\017\016 \022\030\017\023\021 \n\024)Tj 0 Tw (-)Tj -0.028 Tw T* (\032\036\021 \r\026\030\034\017\030\024\r\026\021\034 \024\021 \030\024\n\ \002\024\r\017\007\027\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\002\004\026\021\024\005 \235\024\030\n\t, )Tj -0.045 Tw T* [(\017\n\017\021\017\030\031\016 )0.6(\031\002\004\026\021\t\036 )0.5(\026\007\036\027\024\n\t )0.6([9,22,23].)]TJ /T1_1 1 Tf 0 Tw ( )Tj /T1_0 1 Tf -0.045 Tw 15.977 0 Td [(\025\026\023\017\035\035\016\030\t )0.6(\007\017)]TJ 0 Tw (-)Tj -0.082 Tw -15.977 -1.218 Td (\035\026\021\017\030\024\r\026\027\t, \024\021\n\036\004\026\036\021\f\016\ \017\b \021\030\024\n\002\024. \222\035\036\007\031\036\021 \024\021\n\ \036\021\017\021\034, )Tj 0.112 Tw T* (\004\021\024 \023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\ \022\017 \017\027\024\020\007\026 \f\035\024\032\027\024 \007\017\235\235\ \036\030\036\027)Tj 0 Tw (-)Tj 0.034 Tw T* (\006\017\030\024\r\026\021\034 \027\036\016\r\036\027\027\t\005 \r\026\030\ \017\026\027\021 \f)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\024\022\017\n \022\017\f\021\024\027\t\n )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj -57.136 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.7403 56.0378 Tm (158)Tj ET endstream endobj 520 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, \202\n\017\013\t\025\016\ )-10(\026\n\r\017 )]TJ 0 -1 TD [(\n\022\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217\ \r\022\020\004\225\004\t\n\206 \(\025\255\212\025\005\022\020\n\026)11(\004\005\017\026)-20(\002\005\217\))]TJ 36.829 1 Td [(Solitar)-31(y r)31(ectal ulcer: mechanisms of\022de)11(v)12(elopment, diagnosis )]TJ 5.447 -1 Td [(and modern appr)20(oach)11(es to\022tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ ET 0 0 0 1 K /GS1 gs q 1 0 0 1 42.5197 711.1159 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tc 0.14 Tw 8 0 0 8 42.5596 731.2159 Tm [(ADDRESS)4.9( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.145 Tw 14.294 0 Td [( Elena A. Bogd)26(anov)16(a, )0.5(Ryzhikh N)18(ational )0.5(Medical R)21(esearch )0.5(Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46(roctology)42.1(, Salyama )0.5(Adilya st., 2, )]TJ 0.023 Tw -14.299 -1.2 Td [(Moscow)52(, 123423, R)22(ussia; e-mail: info@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 16.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 16.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 651.7618 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf -0.023 Tw 10 0 0 10 42.5197 627.4058 Tm (\222\024\035\017\021\026\030\027\026\016 \016\r\026 \023\030\016\n\024\005\ \022\017\001\022\017 \(\222\242\215\025\))Tj /Span<>> BDC ( )Tj EMC (\227 \220\021\024 \007\024\f\021\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.027 Tw 0 -1.218 TD (\021\024\004\027\024 \030\036\007\022\024\036, \n\026\035\024\017\031\004\ \036\027\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\035\024\b\024 \023\024\007\007\026\033\013\036\036\f\016)10( )]TJ 0.117 Tw T* [(\035\036\004\036\027\017\033 \026\002\024\035\036\r\026\027\017\036, \027\ \036 \017\n\036\033\013\036\036 \f\023\036\006\017\235\017\004\036\f\022\ \017\b)10( )]TJ 0.296 Tw T* (\f\017\n\023\021\024\n\024\r \017)Tj /Span<>> BDC ( )Tj EMC [(\b\026\030\026\022\021\036\030\017\031\033\013\036\036\f\016 \022\024\n\ \023\035\036\022\f\024\n \022\026\022)10( )]TJ 0.442 Tw T* (\022\035\017\027\017\004\036\f\022\017\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \017\027\f\021\030\ \031\n\036\027)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.289 Tw T* (\021\026\035\034\027\t\b \023\030\024\016\r\035\036\027\017\005, \020\035\ \026\r\027\t\n \023\030\017\027\026\022\024\n \022\024\021\024\030\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.149 Tw T* (\020\024, \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\026\r\035\016\033\013\036\n \002\024\035\034\001\017\027\f\021\ \r\036 \f\035\031\004\026\036\r, \016\r\035\016\036\021\f\016)10( )]TJ 0.212 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\036 \016\r\036\027\027\024\020\ \024 \007\036\235\036\022\021\026 \f\035\017\017\f\021\024\005 \024\002\ \024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.514 Tw T* [(\035\024\004\022\017 \007\017\f\021\026\035\034\027\024\020\024 \024\021\ \007\036\035\026 \022\017\001\036\004\027\017\022\026. \200\023\036\030\r\ \t\036)9.9( )]TJ 0.195 Tw T* [(\024\023\017\f\026\035 )0.5(\024\007\017\027\024\004\027\031\033 )0.5(\016\r\031 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\023\026\021\024\035\024\020\024\026)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.12 Tw T* [(\027\026\021\024\n Cr)-22(uveilhier)]TJ /Span<>> BDC ( )Tj EMC (J. [1] \r)Tj /Span<>> BDC ( )Tj EMC (1829 \020\024\007\031, \026)Tj /Span<>> BDC ( )Tj EMC (\027\024\024\035\024\020\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.217 Tw T* [(\f\022\024\036 \027\026\017\n\036\027\024\r\026\027\017\036 \002\t\035\024\ \023\030\036\007\035\024\032\036\027\024 \002\030\017\021\026\027\f\022\ \017\n)10( )]TJ 0.126 Tw T* [(\b\017\030\031\030\020\024\n Ll)30(oyd-Dav)-16(ies)]TJ /Span<>> BDC ( )Tj EMC (O.V. \r)Tj /Span<>> BDC ( )Tj EMC [(1937 \020\024\007\031 [2]. \222\023\031\f\021\016)10( )]TJ -0.004 Tw T* (40 \035\036\021, \r)Tj /Span<>> BDC ( )Tj EMC (1969)Tj /Span<>> BDC ( )Tj EMC (\020\024\007\031 Madigan)Tj /Span<>> BDC ( )Tj EMC (M.R. \017)Tj /Span<>> BDC ( )Tj EMC [(M)-24(or)-10(son B.C. \r\023\036\030)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.525 Tw T* (\r\t\036 \023\030\036\007\f\021\026\r\017\035\017 \007\026\027\027\t\036\ \024)Tj /Span<>> BDC ( )Tj EMC [(\f\017\n\023\021\024\n\024\022\024\n\023\035\036\022\f\036)10( )]TJ -0.029 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \023\030\017\027\ \026\022\026\b \007\026\027\027\024\020\024 \026\002\024\035\036\r\026\027\ \017\016)10( )]TJ 0.136 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \026\027\026\035\017\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\017\016 68)Tj /Span<>> BDC ( )Tj EMC [(\022\035\017\027\017\004\036\f\022\017\b)10( )]TJ 0.29 Tw T* (\f\035\031\004\026\036\r [2]. \200)Tj /Span<>> BDC ( )Tj EMC [(\007\026\035\034\027\036\005\001\036\n, Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC [(K.R.P. \(1975\),)10( )]TJ 0.545 Tw T* [(\031\004\017\021\t\r\026\016 \030\026\027\024\024\002\030\026\017\036 \ \022\035\017\027\017\004\036\f\022\017\b \f\017\n\023\021\024\n\024\r)10( )]TJ 0.528 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r \222\242\215\025, \024\023\030\036\007\036\035\017\035)10( )]TJ 0.14 Tw T* (\007\026\027\027\024\036 \026\002\024\035\036\r\026\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\027\007\030\024\n \(\222\222\242\215\025\) [3]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.04 Tw T* (\f\021\024\016\013\036\036 \r\030\036\n\016 \030\016\007 \026\r\021\024\030\ \024\r \031\021\r\036\030\032\007\026\033\021, \004\021\024 \027\026\017\ \n\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.136 Tw T* [(\027\024\r\026\027\017\036 \026\002\024\035\036\r\026\027\017\016 \027\036\ \016\r\035\016\036\021\f\016 \022\024\030\030\036\022\021\027\t\n, \021\ \026\022)10( )]TJ 0.163 Tw T* [(Cr)-24(espo)]TJ /Span<>> BDC ( )Tj EMC [(P\351r)-24(ez)]TJ /Span<>> BDC ( )Tj EMC (L. \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021. [4] \027\026\t\r\026\033\021 \222\222\242\215\025 \253\ T)47(he)9.9( )]TJ 0.069 Tw T* [(t)-13(hr)-24(ee-l)-30.9(ies disease\273/\253\002\024\035\036\027\034 \021\030\201\b\022\030\026\ \021\027\024\005 \035\032\017\273, \004\021\024)10( )]TJ 0.153 Tw T* (\020\024\r\024\030\017\021 \024)Tj /Span<>> BDC ( )Tj EMC [(\021\030\201\b \027\036\f\024\024\021\r\036\021\f\021\r\017\016\b, \020\007\ \036 \022\026\032\007\024\036 \f\035\024\r\024)10( )]TJ 0.094 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.82 0 Td [(\027\026\017\n\036\027\024\r\026\027\017\017 )0.5(\027\024\024\035\024\020\017\017 )0.5(\027\036 )0.5(\023\024\035\027\024\f\021\034\033 )0.5(\024\021\030\026\032\026\036\021)10( )]TJ 0.15 Tw -0.82 -1.218 Td (\030\036\026\035\034\027\031\033 \022\026\030\021\017\027\031 \026\002\024\ \035\036\r\026\027\017\016. \230\n\036\027\036\027\017\016 \f\035\017\017\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.007 Tw T* [(\f\021\024\005 \024\002\024\035\024\004\022\017 \007\017\f\021\026\035\034\ \027\024\020\024 \024\021\007\036\035\026 \022\017\001\036\004\027\017\022\ \026 \n\024\020\031\021)10( )]TJ 0.318 Tw T* (\r\026\030\034\017\030\024\r\026\021\034 \024\021 \020\017\023\036\030\036\ \n\017\017, \017\027\235\017\035\034\021\030\026\006\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\016)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.096 Tw T* (\r\036\027\027\024\020\024 \007\036\235\036\022\021\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\017\023\024\r\017\007\027\t\b \030\026\030\026\f\021\026\027\ \017\005, \020\007\036)10( )]TJ 0.238 Tw T* (\016\r\t \n\024\020\031\021 \002\t\021\034 \n\027\024\032\036\f\021\r\036\ \027\027\t\n\017, \026)Tj /Span<>> BDC ( )Tj EMC [(\035\024\022\026\035\017\026\006\017\016)10( )]TJ 0.136 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\024\020\024 \023\030\024\006\ \036\f\f\026 \027\036 \024\020\030\026\027\017\004\017\r\026\036\021\f\016\ \023\030\016)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.085 Tw T* (\n\024\005 \022\017\001\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\024\032\036\021 \030\026\f\023\030\024\f\021\030\026\027\016\021\034\f\ \016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc -0.039 Tw T* [(\027\031\033 \021\030\036\021\034 \f\017\020\n\024\r\017\007\027\024\005\ \022\017\001\022\017 [5,6]. \003\026\002\024\035\036\r\026\036\n\024\f\021\ \034)10( )]TJ 0.043 Tw T* [(\222\222\242\215\025 )0.5(\f\024\f\021\026\r\035\016\036\021 )0.5(1\2263,6)]TJ /Span<>> BDC ( )Tj EMC 10.448 0 Td [(\f\035\031\004\026\036\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.866 0 Td [(100 )0.5(\021\t\f\016\004 )0.5(\027\026\f\036)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.041 Tw -15.314 -1.218 Td (\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\024\007, \024\007\027\026\022\024 \007\026\027\027\t\005 \023\024\022\ \026\026\021\036\035\034 \027\036 \016\r\035\016\036\021\f\016)10( )]TJ 0.293 Tw T* [(\017\f\021\017\027\027\t\n, \031\004\017\021\t\r\026\016 \001\017\030\024\ \022\017\005 \007\017\235\235\036\030\036\027\006\017\026\035\034\027\t\005\ )10( )]TJ 0.407 Tw T* [(\030\016\007 \026\002\024\035\036\r\026\027\017\005 \(\200\003\025, \220\ \027\007\024\n\036\021\030\017\024, \027\036\024\023\035\026\017\016\)\ )10( )]TJ 0.022 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\f\r\016\026\027\027\031\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\220\021\017\n \f\035\024\032\027\024\f\021\034 \023\024\f\021\026\027\024\ \r\022\017 \007\017\026\020\027\024\026)10( )]TJ -0.094 Tw T* ([5\2269]. \222\222\242\215\025 \f\021\030\026\007\026\033\021 \035\033\007\ \017 \r\f\036\b \r\024\030\026\f\021\027\t\b \022\026\021\036\020\024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.01 Tw T* (\030\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\f\022\024\n \r\024\030\026\f\021\036 \007\026\027\027\024\036\ \026\002\024\035\036\r\026\027\017\036 \r\f\021\030\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.141 Tw T* (\004\026\036\021\f\016 \030\036\007\022\024, \024\007\027\026\022\024 \n\ \026\035\034\004\017\022\017 \002\024\035\036\033\021 \r)Tj /Span<>> BDC ( )Tj EMC (3\2264)Tj /Span<>> BDC ( )Tj EMC [(\030\026\026)10( )]TJ -0.041 Tw T* [(\004\026\013\036 \007\036\r\024\004\036\022 [10]. \222\030\036\007\017 \r\ \030\024\f\035\024\020\024 \027\026\f\036\035\036\027\017\016 \004\026\013\ \036)10( )]TJ 0.154 Tw T* [(\002\024\035\036\033\021 \035\033\007\017 \n\024\035\024\007\024\020\024\ \r\024\030\026\f\021\026 \(\f\030\036\007\027\017\005 \r\024\030\026\f\ \021)9.9( )]TJ 0.085 Tw T* (30\22640)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\), \f)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n \023\030\036\024\002\035\026\007\026\027\ \017\036\n \031)Tj /Span<>> BDC ( )Tj EMC [(\032\036\027\013\017\027)10( )]TJ 0.049 Tw 23.244 57.237 Td ([5,6]. \222\222\242\215\025 \022\030\026\005\027\036 \030\036\007\022\024\ \r\f\021\030\036\004\026\036\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (\035\017\006 \023\024\032\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc T* (\035\024\020\024 \r\024\030\026\f\021\026)Tj /Span<>> BDC ( )Tj EMC ([11].)Tj /T1_5 1 Tf 0 Tc 0 -2.436 TD (\231\003\t\002\f\002\n\t\235 \t)Tj /Span<>> BDC ( )Tj EMC (\212\004\003\002\n\r\b\r\213)Tj /T1_4 1 Tf 0.923 Tw 0 -1.218 TD (\222\031\013\036\f\021\r\031\036\021 \n\027\024\020\024 \021\036\024\030\ \017\005 \023\026\021\024\020\036\027\036\026 \222\222\242\215\025. )Tj 0.154 Tw T* [(Rut)-30(ter)]TJ /Span<>> BDC ( )Tj EMC (K.R. \017)Tj /Span<>> BDC ( )Tj EMC [(R)-24(iddell)]TJ /Span<>> BDC ( )Tj EMC (R.H. \r)Tj /Span<>> BDC ( )Tj EMC (1975 \020\024\007\031 \023\030\036\007\023\024\035\024\032\017)Tj 0 Tw (-)Tj 0.033 Tw T* (\035\017, \004\021\024 \222\222\242\215\025 \f\r\016\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\036\005 \023\026\021\024\035\024\020\017\ \004\036\f\022\024\005 )Tj 0.384 Tw T* (\023\024\007\r\017\032\027\024\f\021\017 \f\035\017\017\f\021\024\005 \024\ \002\024\035\024\004\022\017 \007\017\f\021\026\035\034\027\t\b \024\021\ )Tj 0 Tw (-)Tj 0.179 Tw T* (\007\036\035\024\r \023\030\016\n\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 \023\024\035\031\024\022\030\031\032\027\ \024\f\021\017, )Tj 0.037 Tw T* [(\021\022\026\027\036\r\024\005 )0.5(\017\001\036\n\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.362 0 Td [(\023\024\f\021\024\016\027\027\024\005 )0.5(\021\030\026\r\n\026\021\017\026\006\017\017 )0.6(\220\021\024\020\024 )]TJ -0.021 Tw -8.362 -1.218 Td (\031\004\026\f\021\022\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\n \027\026\021\031\032\017\r\026\027\ \017\017 \r\024 \r\030\036\n\016 \007\036\235\036)Tj 0 Tw (-)Tj -0.021 Tw T* (\022\026\006\017\017 [12]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\n\027\036\027\017\033 Du Boul)-16(a)15(y)]TJ /Span<>> BDC ( )Tj EMC (C.E. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1983\), )Tj 0.157 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.91 0 Td [(\017\002\t\021\024\004\027\t\n )0.5(\f\024\022\030\026\013\036\027\017\017 )0.5(\035\024\002\022\024\r\024-\023\030\016\n\024\022\017\001\036\004)]TJ 0 Tw (-)Tj 0.041 Tw -1.91 -1.218 Td (\027\024\005 \n\t\001\006\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\017 \r\027\031\021\030\017\002\030\033\001\027\ \024\020\024 \007\026\r\035\036\027\017\016 )Tj 0.138 Tw T* (\023\036\030\036\007\027\016\016 \f\021\036\027\022\026 \023\030\016\n\024\ \005 \022\017\001\022\017 \023\030\024\035\026\002\017\030\031\036\021 \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.064 Tw T* (\f\r\036\021 \022\017\001\022\017 \r\023\035\024\021\034 \007\024)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026, \023\036\030\ \036\022\030\t\r\026\016 )Tj 0.232 Tw T* (\036\020\024, \023\030\036\023\016\021\f\021\r\031\016 \007\036\235\036\022\ \026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 )Tj 0.109 Tw T* [(\026\002\024\035\036\r\026\027\017\016 )0.6(\004\026\f\021\034 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\n\024\032\036\021 )0.5(\f\007\026\r)]TJ 0 Tw (-)Tj 0.545 Tw T* (\035\017\r\026\021\034\f\016 \f\024\022\030\026\013\026\033\013\017\n\f\016\ \f\235\017\027\022\021\036\030\024\n, \031\f\031\020\031\002\035\016\016\ )Tj 0.15 Tw T* (\021\022\026\027\036\r\031\033 \017\001\036\n\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\024\035\027\017\021\036\035\034\027\024 \021\030\026\r\n\017\ \030\031\016 \f\035\017)Tj 0 Tw (-)Tj 0.125 Tw T* (\017\f\021\031\033 [13]. \212\024)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\020\024 P)40(ar)-23.9(k)-10(s)]TJ /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (1966 \020\024\007\031 )Tj 0.05 Tw T* (\027\026\r\026\035\017 \007\026\027\027\t\005 \023\026\021\024\020\036\027\ \036\021\017\004\036\f\022\017\005 \023\030\024\006\036\f\f \n\036\b\026\ \027\017)Tj 0 Tw (-)Tj 0.023 Tw T* (\n\024\n \253\b\035\024\023\026\033\013\036\005 \026\f\035\024\027\022\017\ \273 [14]. \210\007\027\026\022\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 )Tj -0.026 Tw T* [(Ni)-16(v)]TJ /Span<>> BDC ( )Tj EMC 1.534 0 Td [(Y. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.708 0 Td [(\f\024\026\r\021. )0.5(\(1981\) )0.5([15], )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 8.504 0 Td [(\021\026\022\032\036 )0.5(Sadeghi)]TJ /Span<>> BDC ( )Tj EMC 6.033 0 Td [(A. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 1.781 0 Td (\f\024\026\r\021. )Tj 0.087 Tw -19.56 -1.218 Td [(\(2019\) [6] )0.5(\f\031\013\036\f\021\r\031\036\021 )0.5(\007\r\026 \024\f\027\024\r\027\t\b )0.5(\n\036\b\026\027\017\n\026 )0.5(\030\026)]TJ 0 Tw (-)Tj 0.297 Tw T* (\r\017\021\017\016 \026\002\024\035\036\r\026\027\017\016, \022\024\021\ \024\030\t\n\017 \016\r\035\016\033\021\f\016 \n\036\b\026\027\017\004\036\ )Tj 0 Tw (-)Tj 0.186 Tw T* (\f\022\017\005/\021\030\026\r\n\026\021\017\004\036\f\022\017\005 \(\b\030\ \024\027\017\004\036\f\022\017\005 \n\036\007\035\036\027\027\024-\021\030\ \026\027)Tj 0 Tw (-)Tj 0.303 Tw T* (\017\021\027\t\005 \026\023\024\030, \030\036\022\021\026\035\034\027\t\ \005 \023\030\024\035\026\023\f\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\031\007\017\f\021\t\005 )Tj 0 Tw T* (\(\017\001\036\n\017\016)Tj /T1_2 1 Tf (\))Tj /T1_4 1 Tf 0.179 Tw [(. \025\030\024\n\036 \021\024\020\024, T)40(and)-16(on)]TJ /Span<>> BDC ( )Tj EMC (R.K. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(1990\) )Tj 0.17 Tw T* (\023\030\036\007\023\024\035\024\032\017\035\017, \004\021\024 \016\r\026\ \023\030\016\n\024\005 \022\017\001\022\017 \n\024\032\036\021 \002\t\021\ \034 )Tj 0.073 Tw T* (\023\030\024\016\r\035\036\027\017\036\n \f\017\f\021\036\n\027\024\020\024\ \026\002\024\035\036\r\026\027\017\016 \026\031\021\024\017\n\n\031\027\ \027\024)Tj 0 Tw (-)Tj 0.084 Tw T* (\020\024 \b\026\030\026\022\021\036\030\026 \017\035\017 \027\036\f\022\024\ \035\034\022\017\b \026\002\024\035\036\r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004)Tj 0 Tw (-)Tj T* (\027\024\005 \220\021\017\024\035\024\020\017\036\005 [16].)Tj 0.215 Tw T* (\222\030\036\007\017 \235\026\022\021\024\030\024\r, \f\023\024\f\024\002\ \f\021\r\031\033\013\017\b \030\026\r\017\021\017\033 \222\222\242\215\025\ , )Tj 0.033 Tw T* (Madigan)Tj /Span<>> BDC ( )Tj EMC (M.R. \017)Tj /Span<>> BDC ( )Tj EMC [(M)-23.9(or)-10(son B.C. \017)]TJ /Span<>> BDC ( )Tj EMC [(\030\016\007 \007\030\031\020\017\b )0.5(\026\r\021\024\030\024\r \r\t)]TJ 0 Tw (-)Tj 0.119 Tw T* [(\007\036\035\016\033\021 )0.6(\021\030\026\r\n\026\021\017\026\006\017\033 )0.5(\f\035\017\017\f\021\024\005 )0.6(\024\002\024\035\024\004\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.724 0 Td (\n\026)Tj 0 Tw (-)Tj 0.005 Tw -20.724 -1.218 Td (\027\031\026\035\034\027\024\n \023\024\f\024\002\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \026\021\030\031\007\027\036\027\027\024\005 \007\ \036\235\036\022\026\006\017\017 )Tj 0.002 Tw T* [([2,17]. )0.6(\221\036\n )0.5(\027\036 )0.6(\n\036\027\036\036, )0.6(Contr)-32.9(a)-17(c)-16(t)17(or )0.5(T.Q. )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.903 0 Td [(Contr)-33(a)-17(c)-15.9(t)17(or )0.5(Q.Q. )]TJ 0.415 Tw -15.903 -1.218 Td (\(1975\) \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \f\r\024\036\020\024 \017\f\f\035\036\007\024\r\026\ \027\017\016 \031\021\r\036\030\032\007\026)Tj 0 Tw (-)Tj 0.106 Tw T* (\033\021, \004\021\024 \007\026\027\027\t\005 \235\026\022\021\024\030 \027\ \036 \024\002\255\016\f\027\016\036\021 \235\024\030\n\017\030\024\r\026\ \027\017\036 )Tj 0.07 Tw T* [(\016\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\007\017\f\021\026\035\034\027\024\005 )0.5(\021\030\036\021\017 )0.5(\f\017\020\n\024\r\017\007\027\024\005 )0.5(\022\017\001\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC 20.283 0 Td (\023\030\016)Tj 0 Tw (-)Tj 0.515 Tw -20.283 -1.218 Td [(\n\024\005 \022\017\001\022\036, \027\026\b\024\007\016\013\017\b\f\016 \ )0.5(\023\030\024\022\f\017\n\026\035\034\027\036\036 \r\t\f\024\021\t )]TJ 0 Tw T* (\023\026\035\034\006\026)Tj /Span<>> BDC ( )Tj EMC ([17].)Tj 0.048 Tw T* [(\200 \030\026\002\024\021\036 F)10(or)-31.9(o)-16(o)17(t)15(an)]TJ /Span<>> BDC ( )Tj EMC [(M., Dar)-32(v)-15.9(ishi)]TJ /Span<>> BDC ( )Tj EMC (M. \(2018 \020.\) [5], \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.073 Tw T* (\032\036 Sadeghi)Tj /Span<>> BDC ( )Tj EMC (A. \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \(2019\) [6] \031\022\026\t\r\026\036\021\f\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\021\024, )Tj 0.217 Tw T* (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\024\002\035\026\007\026\033\013\036\n \002\024\035\034\001\017\ \027\f\021\r\036 \f\035\031\004\026\036\r \222\222\242\215\025 )Tj 0.186 Tw T* (\030\026\r\017\r\026\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\024\027\036 \r\027\031\021\030\036\027\027\036\005 \030\036\022\021\ \026\035\034\027\024\005 \017\027\r\026)Tj 0 Tw (-)Tj 0.213 Tw T* (\020\017\027\026\006\017\017 \017\035\017 \027\026\030\031\032\027\024\020\ \024 \r\t\023\026\007\036\027\017\016 \023\030\016\n\024\005 \022\017\001\ \022\017)Tj /T1_2 1 Tf 0 Tw (.)Tj /T1_4 1 Tf ( )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\006)10(\203\036\033 \035\030\032\240\033)30(\f)42(\032)-21(\227\033\231)]TJ 57.136 0 Td (REVIEW)Tj /T1_6 1 Tf 25 0 0 25 505.5021 56.0378 Tm (157)Tj ET endstream endobj 516 0 obj [524 0 R] endobj 517 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 419.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 419.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 381.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 381.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 132.3176 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 132.3176 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 104.7097 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 104.7097 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-156-166)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 81.7489 695.3259 Tm [(\001\025\020\n\026)11(\017\005\t\017\213 \213\212\b\017 \224\005\213\024\025\221 \r\n\204\r\n:\ \024\004)21(\220)10(\017\t\n\212\024\217 \005\017\212\b\n\026\n\213, )]TJ 1.32 -1.105 Td [(\202\n\017\013\t\025\016)-9.9(\026\n\r\017 \n\022)-23.3(\016\025\b\005\004\024\004\t\t\217\004 \224\025\202\220\025\202\217 \r\022\ )-23.3(\020\004\225\004\t\n\206 )]TJ 0 Tw 5.889 -1.105 Td [(\(\025\255\212\025\005\022)-23.3(\020\n\026)11.1(\004\005\017\026)-20(\002\005\217\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 628.822 Tm [(\006\025\013)21(\202\017\t\025\b\017\022)-23.2(\240.\f)-31(.)]TJ 8.162 0 0 8.162 159.377 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 164.013 628.822 Tm [(, \001\r\005\n\202)-21(\020\004\b\016\r\n\221\022)-23.2(\001.\007.)]TJ 0 Tw 8.162 0 0 8.162 282.8933 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 287.5293 628.822 Tm [(, \035\n\r\002)-20(\026)11.1(\025\b\022)-23.3(\f)-31(.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 373.4258 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 10 0 0 10 70.8661 611.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.2(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, )]TJ 0 -1.2 TD [(\013)62(.\022)-23.3(\235\025\016\r\b\017,1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 587.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.127 Tw 9 0 0 9 119.0551 568.6488 Tm (\037\036\035\034: \022\016\r\007\022\023\017 \026\027\200\020\025\022\016\ \026\013 \032\020\016\021\022\023\022\t, \026\027\023\031\030\013 \030\022\ \020\b\025\031\024\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\t \024\022\025\030\032\031\026\020 \024\031\f\022\ \023\020\032\025\031\235 \t\016\021\013 \033\032\t\026\031\235 )Tj 0.257 Tw 0 -1.111 TD (\n\022\213\n\022 \(\205\205\226\004\202\), \021\n\f\005\007\020\t \021\031\ \016\026\031\255\025\031\024\023\017 \033\032\022\026\027\025\027\025\022\ \t \020\r\023\031\f\031\b\022\007\025\013\200 \024\023\021\031\f\031\021\ \013\200 \n\f\027\023\031\n \(\205\202\), \033\031\f\r\007\027\025\025\013\ \200 )Tj 0.023 Tw T* (\022\016)Tj /Span<>> BDC ( )Tj EMC (\255\022\032\031\021\031\235 \023\n\020\025\022 \(\234\).)Tj 0.157 Tw T* [(\205\022\025\030\032\031\026 )0.5(\024\031\f\022\023\020\032\025\031\235 \t\016\021\013 )0.5(\033\032\t\026\031\235 \n\022\213\n\022 )0.5(\(\205\205\226\004\202\))]TJ /Span<>> BDC ( )Tj EMC 21.814 0 Td [(\227 \204\023\031 )0.5(\200\032\031\025\022\007\027\024\n\031\027, )0.5(\032\027\006\022\030\022\021\022\032\r\005\212\027\027 \016\020\240\031\f\ \027\021\020\025\022\027, )0.5(\025\027 )]TJ 0.076 Tw -21.814 -1.111 Td (\022\026\027\005\212\027\027 \024\033\027\006\022\203\022\007\027\024\n\022\ \200 \024\022\026\033\023\031\026\031\021, \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\t\024\025\031\235 \204\023\022\031\f\031\b\022\027\235 \022)Tj /Span<>> BDC ( )Tj EMC (\033\020\023\031\b\027\025\027\016\031\026, \021\020\032\022\020\240\027\ \f\017\025\031\235 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\235\ )Tj 0.288 Tw 0 -1.111 TD (\n\020\032\023\022\025\031\235 \021\031\024\033\020\f\022\023\027\f\017\025\ \013\200 \022\016\026\027\025\027\025\022\235 \024\f\022\016\022\024\023\ \031\235 \031\240\031\f\031\007\n\022 \030\022\024\023\020\f\017\025\013\ \200 \031\023\030\027\f\031\021 \255\027\f\r\030\031\007\025\031-\n\022\213\ \027\007\025\031\b\031 )Tj 0.277 Tw 0 -1.111 TD (\023\032\020\n\023\020. \220\022\020\b\025\031\024\023\022\n\020 \205\205\ \226\004\202 \021)Tj /Span<>> BDC ( )Tj EMC (\033\032\027\031\240\f\020\030\020\005\212\027\026 \240\031\f\017\213\022\ \025\024\023\021\027 \024\f\r\007\020\027\021 \016\020\023\032\r\030\025\ \027\025\020. \217\240\212\027\b\031 \n\031\025\024\027\025\024\r\024\020\ )Tj 0.002 Tw T* (\033\031)Tj /Span<>> BDC ( )Tj EMC (\020\f\b\031\032\022\023\026\r \f\027\007\027\025\022\t \205\205\226\004\ \202 \025\020)Tj /Span<>> BDC ( )Tj EMC (\024\027\b\031\030\025\t\213\025\022\235 \030\027\025\017 \025\027\023. \ \211)Tj /Span<>> BDC ( )Tj EMC (\024\021\t\016\022 \024)Tj /Span<>> BDC ( )Tj EMC (\204\023\022\026 \026\027\023\031\030\013 \f\027\007\027\025\022\t \026\031\ \b\r\023 \240\013\023\017 \032\020\016\025\013)Tj 0 Tw (-)Tj 0.094 Tw T* (\026\022, \n\020\n \n\031\025\024\027\032\021\020\023\022\021\025\013\026\ \022, \023\020\n \022)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\022\026\022. \217\030\025\020\n\031\ \025\020)Tj /Span<>> BDC ( )Tj EMC (\025\020\024\023\031\t\212\022\235 \026\031\026\027\025\023 \025\027\023\ \032\020\025\030\031\026\022\016\022\032\031\021\020\025\025\013\200 )Tj 0.35 Tw T* [(\n\031\025\023\032\031\f\022\032\r\027\026\013\200 )0.5(\022\024\024\f\027\030\031\021\020\025\022\235, \022\016\r\007\020\005\212\ \022\200 )0.5(\031\023\030\020\f\027\025\025\013\027 )0.5(\032\027\016\r\f\017\023\020\023\013 \f\027\007\027\025\022\t. )0.5(\206\020\016\025\031\031\240\032\020\016\022\027 )0.5(\033\031\030\200\031\030\031\021 )]TJ 0.041 Tw T* (\n)Tj /Span<>> BDC ( )Tj EMC [(\f\027\007\027\025\022\005 )0.5(\205\205\226\004\202 \031\023\032\020\255\020\027\023 )0.5(\025\020\f\022\007\022\027 )0.5(\n\020\n \240\031\f\017\213\031\b\031 )0.5(\n\031\f\022\007\027\024\023\021\020 )0.5(\025\027\032\027\213\027\025\025\013\200 \021\031\033\032\031\024\031\021\ , \023\020\n \022)]TJ /Span<>> BDC ( )Tj EMC (\020\n\023\r\020\f\017\025\031\024\023\017 )Tj 0.023 Tw T* (\030\020\f\017\025\027\235\213\022\200 \022\024\024\f\027\030\031\021\020\ \025\022\235, \021\n\f\005\007\020\t \033\032\022\026\027\025\027\025\022\ \027 \n\f\027\023\031\007\025\013\200 \240\022\031\023\027\200\025\031\f\ \031\b\022\235.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.906 443.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \024\031\f\022\023\020\032\025\020\t \t\016\021\020 \033\032\t\026\031\235\ \n\022\213\n\022, \030\022\020\b\025\031\024\023\022\n\020 \024\031\f\022\ \023\020\032\025\031\235 \t\016\021\013, \f\027\007\027\025\022\027 \024\ \031\f\022\023\020\032\025\031\235 \t\016\021\013, \024\023\021\031\f\031\ \021\013\027 \n\f\027\023\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.036 Tc 0.344 Tw -10.401 -2.617 Td [(\020\036\017)5.1( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.026 Tc 0.349 Tw 9.558 0 Td ( \207\024\020\007\026\027\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \222\022\030\017\007\035\036\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\222.\203., \214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \222\024\035\017\021\026\030\027\026\016 \016\r\026 \023\030\ \016\n\024\005 \022\017\001\022\017: \n\036\b\026\027\017\n\t \030\026\ )Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.17 Tw -9.563 -1.2 Td (\r\017\021\017\016, \007\017\026\020\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\036 \023\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \(\024\002\024\030 \035\017\021\036\030\026\ \021\031\030\t\). )Tj /T1_0 1 Tf -0.023 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.17 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(156\226166.)23( )]TJ -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2026-25-1-156-166)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 119.8147 356.6332 Tm [(Solitar)-30.9(y r)31(ectal ulcer: mechanisms of\022)-23.3(de)11(v)12(elopment, )]TJ -1.29 -1.111 Td [(diagnosis and modern appr)20(oach)11(es to\022)-23.3(tr)31(eatment \(r)31(e)11(vie)11(w\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 312.1292 Tm [(Elena\022)-23.2(A)-31(.\022)-23.3(Bogdanov)10(a)]TJ 8.162 0 0 8.162 187.0589 316.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 191.6949 312.1292 Tm [(, Ser)31(gey\022)-23.2(N.\022)-23.3(Skridle)11(v)10(skiy)]TJ 0 Tw 8.162 0 0 8.162 325.5167 316.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 330.1526 312.1292 Tm [(, Alek)11(sey\022)-23.2(A)-31(.\022)-23.3(Lik)11(utov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 440.6649 316.7912 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 297.79 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 294.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 285.79 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 282.46 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_0 1 Tf 0.131 Tw 9 0 0 9 119.0551 251.9561 Tm [(The mechanis)33(ms of dev)13(elopment, methods of diagnosis and treatment of solitar)-43(y rectal ulcer syndrome \(SR)27.1(US\), )]TJ -0.022 Tw 0 -1.111 TD [(including the possibility of using autologous stem cells obtained from a\ dipose tissue in this pathology are descr)-37(ibed. )]TJ 0.035 Tw T* [(Solitar)-42.9(y ulcer syndrome of the rectum \(SR)27(US\) is a chronic, recur)-15.9(rent disease that does no)13(t hav)13(e specif)-42.9(ic sym)16(p)12.9(toms, )]TJ 0.009 Tw T* [(with unclear aetiology and pathog)12(enesis, v)16(ar)-37(iable endoscopic picture of inf)-22(lammator)-43(y chang)11.9(es in the mucous mem)]TJ 0 Tw (-)Tj -0.019 Tw T* [(brane of the rectum. Diagnosis of SR)27(US is dif)-40(f)-43(icult in the v)16(ast ma)10(jor)-36.9(ity of cases. There is no g)12.1(eneral consensus on the )]TJ 0.013 Tw 0 -1.111 TD [(algor)-36.9(ithms for treating SR)27(US to d)26(ate. T)56(reatment methods can be dif)-39.9(ferent, bo)13(th conser)-42(v)16(ativ)12.9(e and surgical. How)12(ev)13(er)61(, )]TJ 0.126 Tw 0 -1.111 TD [(at the moment there are no randomized controlled tr)-37(ials on late results of treatment. The v)16(ar)-36.9(iety of treatment )]TJ 0.052 Tw T* [(app)46(roaches of SR)27(US ref)-21.9(lects bo)13(th the p)46(resence of a larg)12(e number of unresolv)13(ed issues and the relev)16(ance of fur)-39.9(ther )]TJ 0.023 Tw T* [(research, including the use of cellular bio)13(technology)32.1(.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.906 156.6868 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( solitar)-42.9(y rectal ulcer)61.1(, diagnosis of)]TJ /Span<>> BDC ( )Tj EMC [(solitar)-42.9(y ulcer)61(, treatment of)]TJ /Span<>> BDC ( )Tj EMC [(solitar)-42.9(y ulcer)61(, stem cells)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.025 Tc -0.043 Tw -9.871 -2.617 Td [(F)3(O)-4.8(R)8.5( )0.5(C)-17.7(I)-15.8(T)45.2(A)37.3(T)-24.7(I)-1.5(ON:)]TJ /T1_3 1 Tf 0.012 Tc -0.035 Tw 6.248 0 Td [( )0.5(B)-14.1(o)-17.8(g)-11.6(d)-8.5(a)-6.7(n)-11.2(o)-9.5(v)-27.5(a)]TJ /Span<>> BDC ( )Tj EMC 5.068 0 Td [(E)-4.8(.)-23.1(A)-22.2(.)-22.7(,)0.5( )0.5(S)-11.8(k)-24.9(r)-55.6(i)-8(d)-10.4(l)-22.9(e)-15(v)-28.1(s)-10.3(k)-40.3(i)-16.4(y)]TJ /Span<>> BDC 7.277 0 Td ( )Tj EMC 0.21 0 Td [(S)-8.8(.)-1.1(N)-2(.)-22.7(,)0.5( )0.5(L)-11.4(i)-5.8(k)-14.1(u)-15.5(t)-21.1(o)-9.5(v)]TJ /Span<>> BDC 5.277 0 Td ( )Tj EMC 0.21 0 Td [(A)-22.2(.)-23.1(A)-22.2(.)0.5( )0.5(S)-24.4(o)-14.8(l)-15.9(i)-15(t)-36(a)-9.4(r)-59.8(y)0.5( r)-18.3(e)-18.2(c)-40.8(t)-35.9(a)-10.6(l)0.5( u)-7.6(l)-21.1(c)-8.9(e)-11.3(r)-23.9(:)0.5( )0.5(m)-15.8(e)-18.3(c)-9.4(h)-7.5(a)-6.8(n)-13.2(i)-6.6(s)-5.8(m)-10.8(s)0.5( o)-11.3(f)]TJ /Span<>> BDC 17.101 0 Td ( )Tj EMC 0.21 0 Td [(d)-14.5(e)-15(v)-17.9(e)-17.2(l)-20.1(o)-7.5(p)-12.2(m)-15.8(e)-10.7(n)-16.5(t)-52.4(,)0.5( )0.5(d)-15(i)-4.3(a)-10(g)-8(n)-11.2(o)-15(s)-25.3(i)-6.6(s)0.6( a)-6.8(n)-13.7(d)0.5( m)-11.6(o)-19.6(d)-14.5(e)-11.3(r)-35.1(n)12( )]TJ -0.005 Tc -0.048 Tw -41.605 -1.2 Td [(a)-8.2(p)-11.8(p)-13.1(r)-15.2(o)-17.6(a)-10.6(c)-9.6(h)-14.5(e)-22.3(s t)-21.3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-30.2(r)-18.5(e)-12.4(a)-17.7(t)-25.5(m)-16(e)-10.9(n)-16.8(t \()39.8(r)-18.5(e)-15.3(v)-51.2(i)-10.4(e)-11.9(w)20.1(\))11(. )]TJ /T1_0 1 Tf 0.001 Tc -0.001 Tw [(K)10.5(o)-3.5(lo)-3.5(p)-1(rok)-22.6(t)-1.2(o)-3.5(lo)-6.8(g)-16.6(i)3.3(a)2.4(.)]TJ /T1_3 1 Tf 0.003 Tc -0.056 Tw 20.513 0 Td [( 20)4.8(2)12.8(6)28.4(;)18.4(2)7.2(5)9.5(\()46.3(1)52.8(\))23.1(:)29.5(1)9.5(56)-17.4(\226)59.4(1)21.2(6)-2.2(6)13.5(.)8.3( \()7.7(i)5.4(n)8.3( R)2.1(u)-13.3(s)-13.7(s)-7(.)51.8(\))19(.)8.3( 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R)-24(isk f)16(a)-17(c)-16(t)17(or)-10(s of)]TJ /Span<>> BDC ( )Tj EMC [(post-end)-16(oscopic )]TJ 0.184 Tw -1.296 -1.25 Td [(submucosal )0.6(dissec)-15.9(t)-32(ion )0.6(elec)-16(tr)-32(o)-16(coa)-17(gul)-15.9(a)15(t)-32(ion )0.5(syndr)-31.9(ome )0.6(for )0.6(col)30(or)-24(ec)-16(t)15(al )]TJ 0 Tw T* [(neopl)-16(as)26(m)]TJ /T1_2 1 Tf 0.334 Tw (. J Gastroenterol Hepatol.)Tj /T1_1 1 Tf ( 2018 Dec;33\(12\):2001\2262006. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/jgh.14302)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2018 Jun 26. PMID: 29864790.)Tj 0.104 Tw -1.847 -1.25 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-16(himur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(T, Iw)-12(asak)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(H, Ozek)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. 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PMID: 38098318.)Tj 0.125 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)15(teinbr\374ck)]TJ /Span<>> BDC ( )Tj EMC 4.639 0 Td [(I, )0.5(Ebigbo)]TJ /Span<>> BDC ( )Tj EMC 4.036 0 Td [(A, )0.5(K)25.1(uellmer)]TJ /Span<>> BDC ( )Tj EMC 4.953 0 Td [(A, )0.6(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.285 0 Td [(al. )0.5(Cold )0.6(V)30(er)-10(sus )0.6(Ho)17(t )0.5(Snar)-23.9(e )]TJ 0.109 Tw -17.209 -1.25 Td [(End)-16(oscopic R)13(esec)-16(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ar)-32(ge N)-14(on)11(peduncul)-16(a)15(ted Col)30(or)-23.9(ec)-16(t)15(al P)10(ol)35(yps: )]TJ 0.166 Tw T* [(R)-10(and)-16(omized Contr)-32(olled Ger)-15.9(man CHRONICLE )0.5(T)49.9(r)-36.9(ial. )]TJ /T1_2 1 Tf 0 Tw (Gastroenterology)Tj /T1_1 1 Tf (. )Tj 0.057 Tw 29.055 48.75 Td [(2024 Sep;167\(4\):764\226777. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1053/j.gastr)-31.9(o.2024.05.013)]TJ 0 0 0 1 k /GS1 gs 0.057 Tw ( Epub )Tj 0.023 Tw T* [(2024 Ma)15(y 23. 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(\027\026\004\017\021\036\035\034\027\024 \027\017\032\036, \004\036\n \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036: \002\ \024\035\034 )Tj 0.028 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021\036 3/107 \(2,8%\) \023\030\024\021\017\r 16/107 \(15\ %\), )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.028 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,01 )Tj 0.043 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.793 0 Td [(\035\017\b\024\030\026\007\022\026 )0.6(1/107 )0.5(\(1%\) )0.5(\023\030\024\021\017\r )0.6(9/107 )0.5(\(8%\), )]TJ /T1_1 1 Tf 0 Tw 17.918 0 Td (\032)Tj /T1_0 1 Tf 0.043 Tw /Span<>> BDC ( )Tj EMC 0.753 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td (0,05, )Tj 0.353 Tw -20.24 -1.218 Td [(\f\024\024\021\r\036\021\f\021\r\036\027\027\024. )0.6(\211\030\024\r\027\017 )0.5(\r\024\f\023\026\035\017\021\036\035\034\027\t\b )0.6(\n\026\030\022\036\030\024\r )]TJ 0.064 Tw T* (\022\030\024\r\017 \021\026\022\032\036 \002\t\035\017 \027\026\004\017\ \021\036\035\034\027\024 \027\017\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036, \023\024\035\031)Tj 0 Tw (-)Tj 0.226 Tw 0 -1.218 TD (\004\026\r\001\036\005 \026\027\021\017\002\017\024\021\017\022\017, \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 )Tj 0.323 Tw 0 -1.218 TD (\020\030\031\023\023\024\005: \035\036\005\022\024\006\017\021\024 2/10\ 7 \(1,8%\) \023\030\024\021\017\r 12/107 )Tj 0 Tw T* (\(11,2%\), )Tj /T1_1 1 Tf 3.589 0 Td (\032)Tj /T1_0 1 Tf -0.013 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,01 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\255\036\n \222-\030\036\026\022\021\017\r\027\024\020\024 \002\ \036\035\022\026 2/107 )Tj 0.12 Tw -3.589 -1.218 Td (\(1,8%\) \023\030\024\021\017\r 8/107 \(7,5%\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.12 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05 [15]. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\021\036 )Tj 0.162 Tw T* [(S)-16(hi \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\031\033 \020\030\031\023\023\031 \002\ \t\035\024 \r\022\035\033)Tj 0 Tw (-)Tj 0.049 Tw T* (\004\036\027\024 38)Tj /Span<>> BDC ( )Tj EMC (\004\036\035\024\r\036\022 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\f\027\024\r\027\031\033 \020\030\031\023\023\031)Tj /Span<>> BDC ( )Tj EMC (\227 77 \004\036\035\024\r\036\022, )Tj 0.021 Tw 0 -1.218 TD (\027\036 \002\t\035\024 \r\t\016\r\035\036\027\024 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\ \005 )Tj 0.197 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\017 \035\017\b\024\030\026\007\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\016 \031\030\024\r\027\016 \r\024\f\023\026\ )Tj 0 Tw (-)Tj 0.267 Tw 0 -1.218 TD (\035\017\021\036\035\034\027\t\b \n\026\030\022\036\030\024\r \022\030\024\ \r\017 \023\024\f\035\036 \031\007\026\035\036\027\017\016 \220\023\017\021\ \036)Tj 0 Tw (-)Tj 0.274 Tw T* (\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\ \017\005 \n\036\021\024\007\024\n \n\031\022\024\220\022\021\024\n\017\017\ )Tj 0.246 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\024\035\031\004\026\r\001\017\b\ \017\027\255\036\022\006\017\017 \035\036\r\024\235\035\024\022\f\026\006\ \017)Tj 0 Tw (-)Tj 0.089 Tw T* (\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 3)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (0,4 \020\030\026\n\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \017\035\017 \006\036\235)Tj 0 Tw (-)Tj 0.235 Tw T* [(\021\026\017\007\017\n\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.244 0 Td [(\021\036\004\036\027\017\036 )0.6(3)]TJ /Span<>> BDC ( )Tj EMC 4.715 0 Td [(\007\027\036\005 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 3.927 0 Td [(1,0 )0.5(\020\030\026\n\n\031 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.983 0 Td (\f\031\021\022\017 )Tj 0.037 Tw -19.869 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \027\036 \023\024\035\031\004\026\ \r\001\017\b \026\027\021\017\002\026\022)Tj 0 Tw (-)Tj 0.058 Tw T* (\021\036\030\017\026\035\034\027\t\036 \023\030\036\023\026\030\026\021\t\ , 2/38 \(5%\) \023\030\024\021\017\r 0/77 \(0%\), )Tj 0.077 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024 [16]. \200)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 Zheng \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. )Tj -0.027 Tw T* (\021\026\022\032\036 \002\t\035 \023\030\024\r\036\007\036\027 \026\027\026\ \035\017 \030\026\r\017\021\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \035\017)Tj 0 Tw (-)Tj 0.056 Tw T* [(\b\024\030\026\007\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.478 0 Td [(\002\024\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.05 0 Td [(\032\017\r\024\021\036 )0.5(\023\024\f\035\036 )0.6(\r\t\023\024\035\027\036\027\027\024\005 )0.6(\n\031\022\024)]TJ 0 Tw (-)Tj 0.146 Tw -7.528 -1.218 Td [(\220\022\021\024\n\017\017. \215\026\006\017\036\027\021\026\n )0.5(\024\f\027\024\r\027\024\005 \020\030\031\023\023\t, \r\022\035\033\004\026\ \033\013\036\005 )]TJ 0.134 Tw T* (120)Tj /Span<>> BDC ( )Tj EMC (\004\036\035\024\r\036\022, \r\r\024\007\017\035\017 1,0 \020\030\026\n\n\ \006\036\235\017\022\f\017\n\026 \r\027\031\021\030\017)Tj 0 Tw (-)Tj -0.008 Tw T* (\r\036\027\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (30)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\031\021 \007\024)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \036\013\036 \024\007\027\031 )Tj 0.318 Tw T* (\007\024\031 \026\027\021\017\002\017\024\021\017\022\026 \004\036\030\036\  6 \004\026\f\024\r \023\024\f\035\036 \024\023\036\030\026\006\017\017\ , )Tj -0.008 Tw T* (126)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \022\024\027\021\030\024\035\034\027\024\ \005 \020\030\031\023\023\t \r\t\023\024\035\027\016\035\017 \n\031\022\024\ )Tj 0 Tw (-)Tj -0.077 Tw T* [(\220\022\021\024\n\017\033 )0.5(\002\036 )0.6(\022\026\022\024\005-\035\017\002\024 )0.5(\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022\021\017\022\017. )]TJ 0.018 Tw T* (\204\036\032\007\031 \024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\024\005\ \027\036 \002\t\035\024 \r\t)Tj 0 Tw (-)Tj 0.14 Tw T* (\016\r\035\036\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 )Tj 0.096 Tw T* (\030\026\r\017\021\017\016 \035\017\b\024\030\026\007\022\017, \002\024\ \035\036\r\t\b \024\013\031\013\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 )Tj -0.012 Tw T* (\023\024\035\024\f\021\017 \017\035\017 \031\030\024\r\027\016 \r\024\f\023\ \026\035\017\021\036\035\034\027\t\b \n\026\030\022\036\030\024\r \022\030\ \024\r\017, )Tj 0.117 Tw T* (14/120 \(12%\) \023\030\024\021\017\r 13/126 \(10%\), \f\024\024\021\r\036\ \021\f\021\r\036\027\027\024 )Tj 0.331 Tw T* ([17]. \215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005\ \f\017\027\007\030\024\n \007\036\005\f\021\r\017\021\036\035\034\027\024\ )Tj 0.281 Tw T* (\027\036 \024\022\026\t\r\026\036\021 \030\026\007\017\022\026\035\034\027\ \024\020\024 \022\035\017\027\017\004\036\f\022\024\020\024 \r\035\017\016\ \027\017\016 )Tj -0.008 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.198 0 Td [(\021\036\004\036\027\017\036 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\023\036\030\017\024\007\026, )0.5(\024\007\027\026\022\024 )0.6(\r\t)]TJ 0 Tw (-)Tj 0.018 Tw -1.198 -1.218 Td [(\t\r\026\036\021 )0.6(\007\017\f\022\024\n\235\024\030\021 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.053 0 Td [(\023\026\006\017\036\027\021\024\r, )0.5(\021\030\036\002\031\036\021 )0.5(\023\030\024\r\036\007\036\027\017\036 )]TJ 0.138 Tw -9.053 -1.218 Td (\007\024\023\024\035\027\017\021\036\035\034\027\t\b \007\017\026\020\027\ \024\f\021\017\004\036\f\022\017\b \017\027\r\026\017\r\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036)Tj 0 Tw (-)Tj 0.286 Tw T* (\017\027\r\026\017\r\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ . \221\026\022\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\017 )Tj 0.159 Tw T* (\007\026\027\027\024\020\024 \f\017\027\007\030\024\n\026 \r\024\027\017\ \022\026\036\021 \027\036\024\002\b\024\007\017\n\024\f\021\034 \027\026\ \027\026)Tj 0 Tw (-)Tj 0.512 Tw T* (\004\036\027\017\016 \f\017\f\021\036\n\027\t\b \026\027\021\017\002\026\ \022\021\036\030\017\026\035\034\027\t\b \023\030\036\023\026\030\026\021\ \024\r, )Tj 0.166 Tw T* (\r\r\017\007\031 \r\t\f\024\022\017\b \006\017\235\030 \f\036\023\021\017\ \004\036\f\022\017\b \n\026\030\022\036\030\024\r. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\036)Tj 0 Tw (-)Tj 0.22 Tw T* [(\020\024\007\027\016\001\027\017\005 )0.6(\007\036\027\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.309 0 Td [(\n\036\007\017\006\017\027\f\022\024\n )0.5(\f\024\024\002\013\036\f\021\r\036 )0.6(\024\021\f\031\021)]TJ 0 Tw (-)Tj 0.188 Tw -8.309 -1.218 Td (\f\021\r\031\036\021 \036\007\017\027\026\016 \022\024\027\006\036\023\006\ \017\016 \027\036 \021\024\035\034\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\017 )Tj 0.072 Tw T* (\024\023\021\017\n\026\035\034\027\024\020\024 \026\027\021\017\002\026\022\ \021\036\030\017\026\035\034\027\024\020\024 \023\030\036\023\026\030\026\ \021\026, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r )Tj 0.017 Tw T* (\007\024\017\030\024\r\022\036, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\031\021\017 \036\020\024 \r\r\036\007\036\027\017\ \016 \007\035\016 \023\030\024\235\017\035\026\022)Tj 0 Tw (-)Tj 0.117 Tw T* (\021\017\022\017 \215\025\222. \203\036\024\002\b\024\007\017\n\t \004\036\ \021\022\017\036 \022\030\017\021\036\030\017\017 \007\035\016 \023\030\017\ \n\036)Tj 0 Tw (-)Tj 0.188 Tw T* (\027\036\027\017\016 \026\027\021\017\002\017\024\021\017\022\024\023\030\ \024\235\017\035\026\022\021\017\022\017 \023\036\030\036\007 \220\027\007\ \024\f\022\024\023\017)Tj 0 Tw (-)Tj 0.152 Tw T* (\004\036\f\022\017\n \031\007\026\035\036\027\017\036\n \220\023\017\021\ \036\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\ \027\017\005 )Tj 0 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017.)Tj 0.2 Tw T* (\215\030\024\r\036\007\036\027\027\t\005 \n\036\021\026\026\027\026\035\017\  \023\024\022\026\026\035 \f\027\017\032\036\027\017\036 \004\026\f\021\ \024)Tj 0 Tw (-)Tj 0.126 Tw T* (\021\t \030\026\r\017\021\017\016 \023\024\f\021\022\024\026\020\031\035\ \016\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0.043 Tw 23.244 64.543 Td [(\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022\021\017\022\017 )0.7(\f)]TJ /Span<>> BDC ( )Tj EMC 12.206 0 Td [(16,1% )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 3.99 0 Td (5,9%, )Tj /T1_1 1 Tf 0 Tw 2.404 0 Td (p)Tj /T1_0 1 Tf 0.043 Tw /Span<>> BDC ( )Tj EMC 0.753 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.775 0 Td (0,04. )Tj 0.343 Tw -20.129 -1.218 Td [(\210\007\027\026\022\024 \023\024\035\031\004\036\027\027\t\036 \027\026\ \n\017 )0.5(\030\036\031\035\034\021\026\021\t \n\036\021\026\026\027\026\035\017\026\ )]TJ 0.151 Tw T* (\f\035\036\007\031\036\021 \017\027\021\036\030\023\030\036\021\017\030\024\ \r\026\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\024\030\024\032\027\024\f\021\034\033. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.198 Tw T* [(\027\t\005 \n\036\021\026\026\027\026\035\017 \r\022\035\033\004\036\027\ \t )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036 \017\f)]TJ 0 Tw (-)Tj 0.224 Tw T* (\f\035\036\007\024\r\026\027\017\016, \024\007\027\026\022\024 \007\026\027\ \027\t\036 \023\031\002\035\017\022\026\006\017\017 \002\t\035\017 \027\017\ )Tj 0 Tw (-)Tj 0.327 Tw T* (\022\024\020\024 \022\026\004\036\f\021\r\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \031\030\024\r\027\036\n \020\036\021\036\030\024\020\ \036\027\027\024\f\021\017 )Tj 0 Tw 0 -1.218 TD (I)Tj 5.83 0 0 5.83 307.047 655.0919 Tm (2)Tj -0.024 Tw /Span<>> BDC 10 0 0 10 309.962 651.7618 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (80%. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, \027\036 \r\f\036 \r\022\035\033\004\036\027\027\t\036 \017\f\ \f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.172 Tw -0.665 -1.218 Td (\027\017\016 \023\024\f\r\016\013\036\027\t \021\024\035\034\022\024 \220\ \027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\017\f\f\036\022\ \006\017\017 )Tj 0.151 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \023\024\035\024\ \r\017\027\026 \r\024\001\036\007\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 )Tj -0.038 Tw 0 -1.218 TD [(\017\f\f\035\036\007\024\r\026\027\017\005 \026\021\030\026\020\017\r\026\ \033\021 )0.5(\021\036\n\031 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \ )0.5(\030\036)]TJ 0 Tw (-)Tj 0 -1.218 TD (\036\022\006\017\017 \f\035\017\017\f\021\024\005 \024\002\024\035\024\ \004\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017.)Tj 0.397 Tw 0 -1.218 TD (\233\027\007\024\f\022\024\023\017\004\036\f\022\026\016 \007\017\f\f\036\ \022\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 )Tj 0.261 Tw T* (\016\r\035\016\036\021\f\016 \n\026\035\024\017\027\r\026\017\r\027\024\ \005 \n\036\021\024\007\017\022\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \004\026)Tj 0 Tw (-)Tj -0.005 Tw T* (\f\021\024\021\024\005 \024\f\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\002\024\035\034\001\017\n \022\024\035\017\004\036\f\021\r\024\n\ \023\024\f\035\036)Tj 0 Tw (-)Tj 0.257 Tw T* [(\024\023\036\030\026\006\017\024\027\027\t\b )0.6(\022\024\005\022\024-\007\027\036\005, )0.6(\r\027\031\021\030\017\r\036\027\027\024\036 )0.5(\r\r\036\007\036\027\017\036 )]TJ 0.236 Tw 0 -1.218 TD (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\t\b \023\030\ \036\023\026\030\026\021\024\r \f\024\023\030\016\032\036\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024)Tj 0 Tw (-)Tj 0.141 Tw 0 -1.218 TD (\022\017\n \030\017\f\022\024\n \030\026\r\017\021\017\016 \022\026\022\ \n\036\f\021\027\t\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\027\t\b )Tj 0 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005.)Tj 0.579 Tw T* [(\210\021\035\017\004\017\021\036\035\034\027\024\005 )0.6(\024\f\024\002\036\027\027\024\f\021\034\033 )0.6(\023\036\030\024\030\026\035\034\027\024\020\024 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.227 Tw T* (\036\n\026 \023\030\036\023\026\030\026\021\024\r \016\r\035\016\036\021\ \f\016 \023\030\024\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\017\022\026\016 )Tj 0.428 Tw T* (\f\021\024\017\n\024\f\021\034 \007\026\027\027\024\020\024 \n\036\021\024\ \007\026 \023\030\024\235\017\035\026\022\021\017\022\017, \024\007\027\026\ \022\024 )Tj 0.216 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\007\024\f\021\031\023\027\024\005 \035\017\021\036\030\026\ \021\031\030\036 )Tj 0.247 Tw T* (\024\021\f\031\021\f\021\r\031\033\021 \007\026\027\027\t\036 \017\f\f\035\ \036\007\024\r\026\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\024\030\026\035\034\027\024\005 )Tj 0.637 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\036 \023\024\f\021\022\024\026\020\ \031\035\016\006\017)Tj 0 Tw (-)Tj 0.123 Tw T* (\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\024\f\035\036\ \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 \031\007\026\ \035\036\027\017\016 )Tj -0.017 Tw T* (\220\023\017\021\036\035\017\026\035\034\027\t\b \027\024\r\024\024\002\030\ \026\024\r\026\027\017\005 \n\036\021\024\007\024\n \007\017\f\f\036\022\ \006\017\017 )Tj -0.007 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036. \037\036\035\036\ \f\024\024\002\030\026\027\024 \023\030\024\r\036\007\036\027\017\036 \017\ \f)Tj 0 Tw (-)Tj 0.176 Tw T* [(\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 6.63 0 Td [(\023\036\030\024\030\026\035\034\027\024\005 )0.6(\026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\035\026\ \022)]TJ 0 Tw (-)Tj -6.63 -1.218 Td (\021\017\022\036 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\ \027\024\020\024 \f\017\027\007\030\024\n\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 347.3118 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.223 Tw 10 0 0 10 303.3071 322.9558 Tm [(\215\030\024\r\036\007\036\027\017\036 )0.5(\r\027\031\021\030\017\r\036\027\027\024\005 )0.5(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 )0.6(\023\030\024)]TJ 0 Tw (-)Tj 0.534 Tw T* [(\235\017\035\026\022\021\017\022\017 )0.6(\023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\024\020\024\ )0.6(\f\017\027\007\030\024\n\026 )0.5(\023\036\030\036\007 )]TJ 0.372 Tw T* (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \007\017\f\f\036\ \022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 )Tj 0.115 Tw T* (\023\024\022\026\026\035\024 \220\235\235\036\022\021\017\r\027\024\f\021\ \034 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\220\023\017\021\036\035\017\026\035\034)Tj 0 Tw (-)Tj 0.405 Tw T* (\027\t\n\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\016\n\017\ \021\024\035\f\021\024\005 \022\017\001\022\017, \024\007\027\026\022\024\ )Tj 0.267 Tw T* (\007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\024\030\026\035\034\027\024\005 \026\027\021\017\002\017\024\ \021\017\022\024\023\030\024\235\017\035\026\022\021\017\022\036 )Tj 0.087 Tw T* (\024\021\f\031\021\f\021\r\031\033\021, \004\021\024 \021\030\036\002\031\ \036\021 \023\030\024\r\036\007\036\027\017\036 \023\030\024\f\023\036\022\ \021\017\r\027\t\b )Tj 0 Tw T* (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.365 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.375 Tw [( \004)-1.2(\031)-4(\b)-6.3(\031)-10.8(\024\031\021)-10( \001)18.8(.)33.7(\205)-12.1(.)-2.2(,)-9.9( )]TJ 0 Tc 0 Tw T* [(\035)14.6(\022)7.7(\n)-17.8(\r)2.1(\023)4(\031)9.7(\021 \003)-2.3(.)7.3(\003)-2.3(.)7.8(, \001)14.6(\020)0.6(\016)5.2(\020)1.8(\032\031)9.6(\021 \002)28.8(.)28.5(\211)24.3(.)]TJ /T1_0 1 Tf T* [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw [( \004)-1.1(\031)-4.1(\b)-6.3(\031)-10.8(\024\031\021)-9.9( \001)18.8(.)33.7(\205)-12.1(.)]TJ /T1_0 1 Tf 0.018 Tc -0.018 Tw T* [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw 11.349 0 Td [( \221)-5(\020)-15.1(\f\n)2.7(\020)-8.2(\032)-9.9(\031\021)-10( \003)-12.2(.)-2.7(\003)-12.3(.)]TJ /T1_0 1 Tf 0.002 Tc -0.002 Tw -11.349 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_1 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \004)-1.2(\031)-4(\b)-6.3(\031)-10.8(\024\031\021)-10( \001)18.8(.)33.8(\205)-12.1(.)-2.2(,)-10( \221)-5(\020)-15.2(\f\n)2.7(\020)-8.2(\032)-9.9(\031\021)-10( \003)-12.2(.)-2.7(\003)-12.3(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_1 1 Tf 0.722 Tw [( \221)5(\020)-5.2(\f)10.2(\n)12.7(\020)1.8(\032\031)9.6(\021 \003)-2.3(.)7.3(\003)-2.3(.)7.8(, \035)14.6(\022)7.7(\n)-17.8(\r)2.1(\023)4(\031)9.7(\021 \003)-2.3(.)7.3(\003)-2.3(.)7.9(, )]TJ 0 Tw T* [(\001)14.6(\020)0.6(\016)5.1(\020)1.8(\032\031)9.6(\021 \002)28.9(.)28.5(\211)24.3(.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.133 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.4(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.8(y)-11.8(:)]TJ /T1_1 1 Tf [( N)8(i)7.9(k)12.9(o)-1.1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(P)25(o)-4.4(g)-2.5(o)3.3(s)4.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(A)3.6(l)4.8(e)-28.6(x)2.1(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.1(i)7.9(k)12.5(ut)1.4(o)-0.6(v)33.6(, I)3.3(l)11(y)3.8(a V)53.1(. N)8.8(a)-4.5(z)12.9(ar)2.4(o)-0.6(v)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.8028 56.0378 Tm (154)Tj ET endstream endobj 533 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-10(\026\n\r\017 \224\025\016)-9.9(\026\r)10(\025\017\013)-20(\002\020\213\n\025\t\t\025\013)10.1(\025 )]TJ 0 -1 TD [(\016\n\t\202\005\025\024\017 \224\005\n\022\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 \002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\ \b\017\t\n\221 )]TJ T* [(\026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n \(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022\025\255\212\025\005\022\n\022\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 36.366 2 Td [(Antibacterial pr)31.1(e)10.9(v)12(ention of\022postcoagulation s)10(yndr)20(ome during )]TJ -2.695 -1 Td [(endoscopic r)31(emov)10(al of\022colon neoplasms \(r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.253 Tw 10 0 0 10 42.5197 724.8299 Tm (\215\025\222 \031\007\026\036\021\f\016 \030\026\030\036\001\017\021\034\ \022\024\027\f\036\030\r\026\021\017\r\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD [(\027\017\036\n )0.5(\f\017\f\021\036\n\027\t\b )0.6(\026\027\021\017\002\017\024\021\017\022\024\r, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.186 0 Td [(\027\036\022\024\021\024\030\t\b )0.6(\f\035\031\004\026\016\b )]TJ 0.286 Tw -14.186 -1.218 Td (\022\035\017\027\017\004\036\f\022\024\036 \021\036\004\036\027\017\036 \ \007\026\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\030\024\021\ \036\022\026\036\021 )Tj 0.011 Tw T* (\023\024\007 \n\026\f\022\024\005 \024\021\f\030\024\004\036\027\027\024\ \005 \023\036\030\235\024\030\026\006\017\017 \021\024\035\f\021\024\005\ \022\017\001\022\017, )Tj 0.196 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\024\032\036\021 \017\n\017\021\017\030\024\r\026\ \021\034 \023\036\030\017\021\024\027\036\026\035\034\027\031\033 \f\017\ \n\023)Tj 0 Tw (-)Tj 0.346 Tw T* (\021\024\n\026\021\017\022\031, \004\021\024 \023\030\017\r\024\007\017\021\ \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\033 \023\024\035\024\f\021\027\t\b )Tj 0.083 Tw 0 -1.218 TD (\b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\ \034\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\033 \030\036\r\017\017\017 )Tj 0.154 Tw 0 -1.218 TD (\024\030\020\026\027\024\r \002\030\033\001\027\024\005 \023\024\035\024\ \f\021\017 [10]. \222\017\n\023\021\024\n\t, \r\t\r\026\027)Tj 0 Tw (-)Tj -0.011 Tw T* (\027\t\036 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\ \t\n \f\017\027\007\030\024\n\024\n, \n\024\020\031\021 \017\n\036\027\017\ \021\034 )Tj -0.037 Tw T* [(\r\036\022\021\024\030 )0.5(\022\024\027\f\036\030\r\026\021\017\r\027\024\005 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\021\036\030\026\023\017\017. )]TJ 0.062 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\017 \215\025\222 \r)Tj /Span<>> BDC ( )Tj EMC (66,7% \f\035\031\004\026\036\r \023\026\006\017\036\027\021\026\n \027\026\ )Tj 0 Tw (-)Tj -0.015 Tw T* (\027\026\004\026\033\021 \f\017\f\021\036\n\027\t\036 \023\026\030\036\027\ \021\036\030\026\035\034\027\t\036 \026\027\021\017\002\026\022\021\036\030\ \017\026\035\034)Tj 0 Tw (-)Tj -0.014 Tw 0 -1.218 TD (\027\t\036 \023\030\036\023\026\030\026\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\021\036\030\024\017\007\027\t\036 \023\030\024\021\017\r\024\r\ \024\f\023\026\035\017\021\036\035\034)Tj 0 Tw (-)Tj 0.103 Tw 0 -1.218 TD (\027\t\036 \f\030\036\007\f\021\r\026, \004\021\024 \031\r\036\035\017\004\ \017\r\026\036\021 \f\030\024\022 \020\024\f\023\017\021\026\035\017\026\ \006\017\017 )Tj 0.065 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (3 \007\027\016, \f\021\024\017\n\024\f\021\034 \035\036\004\036\027\017\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (15%, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\027\017\032\026)Tj 0 Tw (-)Tj 0.22 Tw T* [(\036\021 )0.5(\022\026\004\036\f\021\r\024 )0.6(\032\017\027\017 )0.5(\023\026\006\017\036\027\021\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.678 0 Td (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )Tj 0.216 Tw -13.678 -1.218 Td (\023\036\030\017\024\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\031\007\035\017\027\036\027\017\036\n \023\036\030\017\024\007\026 \020\ \024\035\024\007\026\027\017\016 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\030\026\026 [7,3].)Tj 0.162 Tw T* (\025\035\026\f\f\017\235\017\006\017\030\031\033\021 \007\r\026 \021\017\ \023\026 \215\025\222)Tj /Span<>> BDC ( )Tj EMC (\227 I \021\017\023 \b\026\030\026\022\021\036\030\017)Tj 0 Tw (-)Tj 0.521 Tw T* (\031\036\021\f\016 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\ \027\027\t\n \f\017\027\007\030\024\n\024\n \002\036 \020\026\026 )Tj 0.085 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\024\035\017\004\036\f\022\024\005 \022\035\036\021\004\ \026\021\022\036; II \021\017\023 \b\026\030\026\022\021\036\030\017\031\ \036\021\f\016 )Tj -0.096 Tw T* (\023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\n \f\017\ \027\007\030\024\n\024\n \f)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036\n \020\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.074 Tw T* [(\030\026\022\024\035\017\004\036\f\022\024\005 )0.6(\022\035\036\021\004\026\021\022\036. )0.5(\215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 )0.6(\f\017\027\007)]TJ 0 Tw (-)Tj -0.077 Tw T* (\030\024\n II \021\017\023\026 \f\024\023\030\024\r\024\032\007\026\036\021\ \f\016 \002\024\035\036\036 \016\030\022\024\005 \022\035\017\027\017\004\ \036\f\022\024\005 )Tj 0.245 Tw T* [(\022\026\030\021\017\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\024\021\035\017\004\017\036 \024\021 I )0.5(\021\017\023\026. \212\017\235\235\036\030\036\027\006\017\030\024\r\026\ \021\034 )]TJ 0.417 Tw T* (\007\026\027\027\t\036 \021\017\023\t \215\025\222 \f\021\026\027\024\r\017\ \021\f\016 \r\024\n\024\032\027\t\n \021\024\035\034\022\024 )Tj 0.093 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\017\017 \022\024\n\023\034\033\021\036\030\ \027\024\005 )0.5(\021\024\n\024\020\030\026\235\017\017 )0.5(\024\030\020\026\027\024\r )]TJ 0.11 Tw T* (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017. \200\t\016\r\035\ \036\027\027\t\005, \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \035\031\004\036\r\024\005 )Tj 0.104 Tw T* (\007\017\026\020\027\024\f\021\017\022\017, \020\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\022\024\035\017\004\036\f\022\024\005 \022\035\036\021\004\ \026\021\022\036 \n\024\032\036\021 )Tj 0.061 Tw T* (\023\024\r\t\f\017\021\034 \030\017\f\022\017 \r\t\023\024\035\027\036\027\ \017\016 \026\002\007\024\n\017\027\026\035\034\027\024\020\024 \b\017\030\ \031\030)Tj 0 Tw (-)Tj T* (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 [6,8].)Tj 0.245 Tw T* (\200 \035\017\021\036\030\026\021\031\030\036 \022)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\n \235\026\022\021\024\030\026\n \030\017\f\022\026\ \023\024\f\021\022\024)Tj 0 Tw (-)Tj 0.583 Tw T* (\026\020\031\035\016\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\ \n\026 \024\021\027\024\f\016\021: \032\036\027\f\022\017\005 \023\024\035\ , )Tj 0.796 Tw T* [(\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )0.5(\024\023\036\030\026\006\017\017 \002\024\035\036\036 )0.5(90 \n\017\027\031\021 )]TJ -0.064 Tw 23.244 40.187 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\024\035\024\032\036\027\017\036 \024\023\031\b\024\035\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024\007\024\004\027\ \024\005 )Tj 0.095 Tw T* (\022\017\001\022\017 [11]. \215\030\024\007\024\035\032\017\021\036\035\034\ \027\024\f\021\034 \024\023\036\030\026\006\017\017, \f\024\020\035\026\f\ \027\024 )Tj 0.383 Tw T* (\024\002\013\036\023\030\017\027\016\021\t\n \007\026\027\027\t\n, \016\r\ \035\016\036\021\f\016 \235\026\022\021\024\030\024\n \030\017\f\022\026\ )Tj -0.033 Tw T* (\030\026\r\017\021\017\016 \007\026\027\027\024\020\024 \f\017\027\007\030\ \024\n\026, \f\031\013\036\f\021\r\031\036\021 \023\030\016\n\026\016 \026\ \r\017)Tj 0 Tw (-)Tj 0.211 Tw T* (\f\017\n\024\f\021\034 \024\021 \030\026\n\036\030\024\r \031\007\026\035\ \016\036\n\024\020\024 \027\024\r\024\024\002\030\026\024\r\026\027\017\ \016, )Tj 0.037 Tw T* (\035\024\022\026\035\017\026\006\017\017 \036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024\007\024\004\027\ \024\005 \022\017\001\022\017 )Tj 0.052 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC [(\r\030\036\n\036\027\036\n \024\023\036\030\026\006\017\017 [12]. \230\f\ \f\035\036\007\024\r\026\027\017\036 Ar)-36.9(imo)17(t)17(o)]TJ /Span<>> BDC ( )Tj EMC (J. )Tj 0.189 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r\022\035\033\004\026\033\013\036\036 106 \023\026\006\ \017\036\027\021\024\r, \023\024\f\r\016\013\201\027\027\024\036 )Tj 0.195 Tw T* (\024\023\030\036\007\036\035\036\027\017\033 \235\026\022\021\024\030\024\ \r \030\017\f\022\026 \023\024\f\021\022\024\026\020\031\035\016\006\017\ \024\027\027\024\020\024 )Tj 0.079 Tw T* [(\f\017\027\007\030\024\n\026 )0.5(\023\024\022\026\026\035\024, )0.6(\004\021\024 )0.5(\r\030\036\n\016 )0.5(\r\t\023\024\035\027\036\027\017\016 )0.6(\220\027\007\024\f\022\024)]TJ 0 Tw (-)Tj 0.159 Tw T* (\023\017\004\036\f\022\024\005 \007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \002\024\035\036\036\ 90 )Tj 0.215 Tw T* (\n\017\027\031\021 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\017\026\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \024\002\024\007\024\004\027\ \024\005 )Tj 0.424 Tw 0 -1.218 TD (\022\017\001\022\017 \016\r\035\016\033\021\f\016 \027\036\026\r\017\f\017\ \n\t\n\017 \235\026\022\021\024\030\026\n\017 \030\017\f\022\026 )Tj 0.102 Tw 0 -1.218 TD (\030\026\r\017\021\017\016 \215\025\222. \221\026\022\024\005 \235\026\022\ \021\024\030 \030\017\f\022\026 \022\026\022 \035\024\022\026\035\017\026\ \006\017\016 )Tj 0.039 Tw 0 -1.218 TD (\024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\021\007\036\035\026\b \021\024\035\f\021\024\005\ \022\017\001\022\017 \024\002\255\016\f\027\016\036\021)Tj 0 Tw (-)Tj -0.022 Tw T* (\f\016 \002\024\035\036\036 \021\024\027\022\024\005 \f\021\036\027\022\024\ \005 \024\030\020\026\027\026, \004\021\024 \f\023\024\f\024\002\f\021\r\ \031\036\021 \002\024)Tj 0 Tw (-)Tj 0.018 Tw T* (\035\036\036 \020\035\031\002\024\022\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\f\021\030\024\n\031 \030\026\f\023\030\024\f\021\030\026\027\036\027\ \017\033 \220\027\036\030\020\017\017 )Tj 0.064 Tw T* (\022\024\026\020\031\035\016\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\036\004\027\t\005 \f\035\024\005 \f\021\036\027\022\017 \022\017\ \001\022\017. \200\030\036\n\016 )Tj 0.065 Tw T* (\023\030\024\r\036\007\036\027\017\016 \220\027\007\024\f\022\024\023\017\ \004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\r\026 \ \n\024\032\036\021 )Tj 0.214 Tw T* (\002\t\021\034 \f\024\022\030\026\013\036\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \023\024\r\t\001\036\027\017\016 \022\r\026\035\017\235\017\ \022\026\006\017\017 )Tj 0.101 Tw T* [(\024\023\036\030\017\030\031\033\013\036\020\024 \b\017\030\031\030\020\026\ )0.5([12]. \210\023\030\036\007\036\035\036\027\017\036 \235\026\022\021\024\030\ \024\r )]TJ 0.037 Tw T* [(\030\017\f\022\026 \023\024\r\024\035\017\021 \030\026\030\026\002\024\ \021\026\021\034 )0.5(\027\024\n\024\020\030\026\n\n\031 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026 )0.5(\007\024\024\023\036)]TJ 0 Tw (-)Tj 0.06 Tw T* (\030\026\006\017\024\027\027\024\n \220\021\026\023\036 \r\t\016\r\035\016\ \021\034 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \030\017)Tj 0 Tw (-)Tj -0.028 Tw T* (\f\022\024\n \r\024\027\017\022\027\024\r\036\027\017\016 \215\025\222 \ \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\006\036\035\034\027\024 \017\f\023\024\035\034\024\r\026\021\ \034 \031 )Tj 0 Tw T* (\027\017\b \026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\017\ \035\026\022\021\017\022\031.)Tj 0.087 Tw T* (\203\026 \007\026\027\027\t\005 \n\024\n\036\027\021 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\007\024\f\021\031\023\027\t\b \017\f\021\024\004\027\017\ \022\026\b \035\017)Tj 0 Tw (-)Tj 0.208 Tw T* (\021\036\030\026\021\031\030\t \017\n\036\033\021\f\016 \007\026\027\027\ \t\036 \021\024\035\034\022\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\r\036\027\027\024\005 )Tj 0.132 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\036 \023\024\f\021\022\024\026\020\ \031\035\016\006\017\024\027)Tj 0 Tw (-)Tj 0.029 Tw T* (\027\024\020\024 \f\017\027\007\030\024\n\026 \023\024\f\035\036 \r\t\023\ \024\035\027\036\027\027\024\005 \220\027\007\024\f\022\024\023\017\004\036\ \f\022\024\005 )Tj -0.039 Tw T* (\007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \030\026\027\007\024\n\017)Tj 0 Tw (-)Tj -0.034 Tw T* [(\017\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\ \017\016 L)35(ee)]TJ /Span<>> BDC ( )Tj EMC (SP. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r \022\024\021\024\030\024\n )Tj 0.14 Tw T* [(\023\030\017\027\016\035\017 )0.5(\031\004\026\f\021\017\036 \023\024)]TJ /Span<>> BDC ( )Tj EMC (50 \004\036\035\024\r\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (2 \020\030\031\023\023\026\b, \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 )Tj 0.003 Tw T* (\022\024\021\024\030\024\020\024 1,5 \020\030\026\n\n\026 \026\n\023\017\ \006\017\035\035\017\027-\f\031\035\034\002\026\022\021\026\n\026 \r\r\024\ \007\017)Tj 0 Tw (-)Tj 0.057 Tw T* (\035\017 \r\027\031\021\030\017\r\036\027\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (1 \004\026\f \007\024, \026)Tj /Span<>> BDC ( )Tj EMC (\026\021\036\n \004\036\030\036 8 \017)Tj /Span<>> BDC ( )Tj EMC (16)Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.026 Tw T* [(\f\024\r \023\024\f\035\036 \220\027\007\024\f\022\024\023\017\004\036\f\ \022\024\005 )0.5(\023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\022\006\017\017\ )]TJ 0.122 Tw T* (\002\t\035\024 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \027\024 \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\036 \030\ \026)Tj 0 Tw (-)Tj 0.368 Tw T* (\r\017\021\017\016 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\ \027\027\024\020\024 \f\017\027\007\030\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 )Tj 0.044 Tw T* (\020\030\031\023\023\036, 1/50 \(2%\) \023\030\024\021\017\r 8/50 \(16%\)\ , )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,031 [13]. )Tj 0.193 Tw T* [(\217\026\027\007\024\n\017\017\030\024\r\026\027\027\024\036 \017\f\f\035\ \036\007\024\r\026\027\017\036 S)-16(hichijo)]TJ /Span<>> BDC ( )Tj EMC (S. \f)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.204 Tw T* (\026\r\021., \r\022\035\033\004\017\r\001\036\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036 \020\030\031\023\023\t 380 \004\036\035\024\r\036\022, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024)Tj 0 Tw (-)Tj 0.329 Tw T* (\021\024\030\024\n 3 \020\030\026\n\n\026 \026\n\023\017\006\017\035\035\ \017\027-\f\031\035\034\002\026\022\021\026\n\026 \r\r\024\007\017\035\017\ )Tj 0.14 Tw T* (\r\027\031\021\030\017\r\036\027\027\024 \027\036\023\024\f\030\036\007\f\ \021\r\036\027\027\024 \023\036\030\036\007, \004\036\030\036 8 \004\026\ \f\024\r )Tj 0.135 Tw T* (\023\024\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \f\035\036\007\031\033\013\036\036 \031\021\030\024 \023\024\f\035\ \036 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 )Tj 0.185 Tw T* (\023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\022\006\017\017\ \027\036 \r\t\016\r\017\035\024 \f\031\013\036\f\021\r\036\027\027\t\b \ )Tj 0.081 Tw T* (\030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022)Tj 0 Tw (-)Tj -0.06 Tw T* (\021\017\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\036)Tj /Span<>> BDC ( )Tj EMC (\227 9/192 \(4,7%\) \023\030\024\021\017\r 14/188 \(7,5%\), )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.163 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,29 [14]. \200)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\017 )0.5(Zhang \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \002\t\035\026 )Tj 0.167 Tw T* (\023\030\024\017\r\036\007\036\027\026 \024\006\036\027\022\026 \030\026\ \r\017\021\017\016 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\ \027\027\024\020\024 )Tj 0.031 Tw T* (\f\017\027\007\030\024\n\026 \022\026\022 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \023\036\030\036\027\036\f\001\017\b \ \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.023 Tw T* [(\f\022\031\033 \007\017\f\f\036\022\006\017\033, )0.5(\021\026\022 \017)]TJ /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\033; \r)Tj /Span<>> BDC ( )Tj EMC 16.812 0 Td (\022\024\027\021\030\024\035\034\027\024\005 )Tj 0.1 Tw -16.812 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\024\005 \020\030\031\023\023\036 \002\t\035\024 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (107 \004\036\035\024\r\036\022. \200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 )Tj -0.018 Tw T* [(\020\030\031\023\023\036 \023\026\006\017\036\027\021\026\n \r\r\024\007\ \017\035\017 )0.5(\006\036\235\031\030\024\022\f\017\n )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC (1,5 \020\030\026\n\n\026 )Tj -0.041 Tw T* (\r\027\031\021\030\017\r\036\027\027\024 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\004\026\f\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\004\036\030\036 6 \004\026\f\024\r \023\024\f\035\036 \024\023\036)Tj 0 Tw (-)Tj 0.137 Tw T* (\030\026\006\017\017. \232\026\f\021\024\021\026 \030\026\r\017\021\017\ \016 \002\024\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 )Tj ET q 42.52 111.77 184.252 192.872 re W n q /GS0 gs 184.2519685 0 0 192.8887796 42.5196838 111.7532492 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.148 Tw 9 0 0 9 42.5197 100.9701 Tm [(\022\t\217\210\b\002\220 )0.5(3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \202\020\007\027\024\023\021\031 \022\024\024\f\027\030\031\021\020\025\ \022\235, )0.6(\021\n\f\005\007\027\025\025\013\200 \021)]TJ /Span<>> BDC ( )Tj EMC 22.056 0 Td (\026\027\023\020)Tj 0 Tw (-)Tj -22.056 -1.2 Td (\020\025\020\f\022\016)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.01 Tc -0.035 Tw 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC [(q)14(uality of)]TJ /Span<>> BDC ( )Tj EMC (the studies included in the)Tj /Span<>> BDC ( )Tj EMC (meta-analy)Tj /Span<>> BDC ( )Tj EMC 23.588 0 Td (sis)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_4 1 Tf 25 0 0 25 505.4271 56.0378 Tm (153)Tj ET endstream endobj 534 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1AQa"q3B #$%&'()*2456789:CDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz!1A"2QaBq#R $%&'()*3456789:CDEFGHIJSTUVWXYZbcdefghijrstuvwxyz?@`*FTh{\i-2;Pllg8Z׭OTkk1 9hԠNM0ZZAخƧ US-}aF @i֍֛֙Tasrnezt*5 {LI 3( oYssχRQc0tGb$') Y/mV pkze7pe6ւOw-.<)7-h%Ù;$j8@EkQ5l+Ҥ{8Vv8OQ{iu{kvmni,45+ 3\mg\֩Y^ƶq""" """е@`sXuĬ,꾛_5j m@Oh:NV:`{j=,vHIH@EE VSnql$ 1܀.Ѷs_TٜEH?mt]qHb +c.^[N 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\S2p-kϸ굪uGq1O<zMCMwS.4[I7߯59juz  lskGy&o~֞ZŎWjpyGK . sU%Zݼ&rXZQՖVIVҲ)V2F3mKznIIوPxsK,,uIوtseWT\[1oIKP{L5`D.}gm&ת)2Llܰ)"?IMƟY$%ReƍZFQZK[h2@[M-ozw&iu;:ZZ*sjhByq3hu,GgUivOW>3䖱eͪ,y=6B44kteց)޺VX7W6,HRZ/~zîcKW,~ŗSIRz]:tq|K;4[\T?J-2wWAi׵@`5{{[:軆؁Ru4Ri; Yz菪Pƪ[:럿e=~9V[5ُPm}~9V{p-jѯz^sECGI#pǤ]ocf>CF@EκO_|~f>Moc[__|~OYe,8S}B%r)}RIQM@"s]s짿>u?~kT1JIl[ m}~9V׀zq{k>zm6W@Rګ$sĮW[5ُPÌe$Gim}~9S:럿ejُS[aF1XIrl2EκY}fx.(>5I4 +I}R(à^bJ»ս潬%k8{s]sV{1JkT$->u?~{s]sV1JkT"߬l:+U7idFji:럿ejُS[cV+y# [__|~κZocf>@EUP5Vqz:n7Z@>j~9V[5ُV0m}~9S:럿ejُS[Imoo nږUAwQ0's̯E8$L(е@` endstream endobj 582 0 obj <>stream endstream endobj 531 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.406 Tw 10 0 0 10 70.8661 371.6679 Tm (\024\023\036\030\026\006\017\017, \021\026\022 \022\026\022 \017\027\f\031\ \235\235\035\017\030\024\r\026\027\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 )Tj 0.037 Tw 0 -1.218 TD (\022\017\001\022\017 \020\026 \r\024 \r\030\036\n\016 \024\023\036\030\026\ \006\017\017 \n\024\032\036\021 \021\026\022\032\036 \r\t\t\r\026\021\034\ )Tj 0 Tw T* (\002\024\035\017, \f\b\024\032\017\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\017\n\023\021\024\n\026\n\017 \215\025\222 [7].)Tj 0.227 Tw T* [(\222\024\020\035\026\f\027\024 \007\026\027\027\t\n \035\017\021\036\030\ \026\021\031\030\t, )0.5(\004\026\f\021\024\021\026 \023\024\f\021\022\024\026\020\031\035\016)]TJ 0 Tw (-)Tj 0.097 Tw T* [(\006\017\024\027\027\024\020\024 )0.5(\f\017\027\007\030\024\n\026 \n\024\032\036\021 )0.5(\007\024\f\021\017\020\026\021\034 )0.5(16% \024\021 \024\002\013\036\020\024 )]TJ 0.384 Tw T* (\022\024\035\017\004\036\f\021\r\026 \r\f\036\b \r\t\023\024\035\027\036\ \027\027\t\b \023\024\007\f\035\017\017\f\021\t\b \007\017\f)Tj 0 Tw (-)Tj 0.177 Tw T* (\f\036\022\006\017\005, \004\021\024 \027\026\004\017\021\036\035\034\027\ \024 \004\026\013\036, \004\036\n \023\024\f\035\036 \r\t\023\024\035\027\ \036)Tj 0 Tw (-)Tj 0.376 Tw T* (\027\017\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \023\ \024\035\017\023\220\022\021\024\n\017\017, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 )Tj 0.186 Tw T* (\007\026\027\027\t\005 \f\017\027\007\030\024\n \030\026\r\017\r\026\036\ \021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (4,4% \f\035\031\004\026\036\r [8,9]. )Tj 0.165 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC 5.709 0 Td [(\021\024, \004\021\024 )0.5(\002\024\035\034\001\017\027\f\021\r\024 \f\035\031\004\026\036\r )0.5(\030\026\r\017\021\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\ \025\023\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\f\r)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s b)-2.3(y g)-6.8(e)-7(n)-4.8(d)-5.3(e)-6(r)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 703.7118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 715.181 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 155.9055 703.7118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 156.1555 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 703.7118 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 692.2426 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 692.2426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 692.2426 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 680.7813 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 680.7813 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 680.7813 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.32 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 669.32 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 669.32 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 657.8588 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 657.8588 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 657.8588 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 646.3975 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 646.3975 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 646.3975 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 634.9362 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 634.9362 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 224.187 634.9362 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 103.3919 700.8118 Tm (\032\003\002\006)Tj 14.26 0.717 Td (\200\002\f)Tj -4.273 -1.434 Td (\032\224\241)Tj 8.504 0 Td (\032\224+)Tj /T1_0 1 Tf -22.171 -1.433 Td (Lee et al.)Tj 12.212 0 Td (\204 68% \(34\))Tj 8.504 0 Td (\204 58% \(29\))Tj -20.716 -1.433 Td (Shichijo et al.)Tj 11.962 0 Td (\204 62% \(118\))Tj 8.504 0 Td (\204 61% \(115\))Tj -20.466 -1.433 Td (Zhang et al.)Tj 12.212 0 Td (\204 63% \(68\))Tj 8.504 0 Td (\204 58% \(62\))Tj -20.716 -1.433 Td (Shi et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Zheng et al.)Tj 12.212 0 Td (\204 52% \(63\))Tj 8.504 0 Td (\204 63% \(68\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 618.2169 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\ \025\023\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\032\020\024\023\r)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s b)-2.3(y a)-5.2(g)-6.8(e)]TJ ET /GS2 gs q 1 0 0 1 70.8661 602.9149 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 591.4457 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 602.9149 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 591.6957 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 602.9149 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 591.6957 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 580.2265 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 155.9055 591.4457 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 156.1555 580.2265 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 591.4457 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 580.2265 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 580.2265 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 579.9765 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 579.9765 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 579.9765 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 568.7652 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 568.5152 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 568.5152 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 568.5152 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 557.3039 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 557.0539 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 557.0539 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 557.0539 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 545.8427 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 545.5927 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 534.3813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 545.5927 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 534.3813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 545.5927 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 534.3813 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 534.1313 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 534.1313 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 534.1313 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 522.92 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 522.67 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 522.67 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 224.187 522.67 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 103.3919 588.5457 Tm (\032\003\002\006)Tj 13.399 0.717 Td (\026\002\213\006\004\217\003)Tj -3.412 -1.434 Td (\032\224\241)Tj 8.504 0 Td (\032\224+)Tj /T1_0 1 Tf -22.171 -1.433 Td (Lee et al.)Tj 11.86 0 Td (60,56)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (12,71)Tj 8.504 0 Td (61,52)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (12,86)Tj -20.364 -1.433 Td (Shichijo et al.)Tj 12.263 0 Td (69)Tj /Span<>> BDC ( )Tj EMC (\(35\22680\))Tj 8.504 0 Td (68)Tj /Span<>> BDC ( )Tj EMC (\(32\22680\))Tj -20.767 -1.433 Td (Zhang et al.)Tj 12.61 0 Td (63,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,5)Tj 8.254 0 Td (68,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (12,5)Tj -20.864 -1.433 Td (Shi et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Zheng et al.)Tj 12.11 0 Td (51,11)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,52)Tj 8.504 0 Td (52,74)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (8,89)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.156 Tw 9 0 0 9 70.8661 505.9508 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\032\031\030\031\f\255\022\023\027\f\017\025\031\024\023\017 \204\025\ \030\031\024\n\031\033\022\007\027\024\n\022\200 \021\026\027\213\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\023\027\f\017\024\023\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.001 Tc -0.001 Tw 3.318 0 Td [( D)-3.1(u)2.6(r)4.4(a)-8.2(t)-28.1(io)-3(n)1( o)5(f)]TJ /Span<>> BDC 4.707 0 Td ( )Tj EMC [(e)-6(n)-3.8(d)-4.2(os)1.1(c)3.8(o)-4.3(p)2.3(i)-0.8(c)1.1( i)4.9(nt)-0.6(e)-5(r)-41.8(v)3.3(e)-6(nt)-28.1(io)-3(n)4.7(s)]TJ ET /GS2 gs q 1 0 0 1 70.8661 479.8488 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 468.3796 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 156.1555 479.8488 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 468.6296 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 479.8488 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 468.6296 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 457.1604 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 155.9055 468.3796 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 156.1555 457.1604 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 468.3796 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 457.1604 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 457.1604 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 456.9104 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 456.9104 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 456.9104 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 445.6991 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 445.4491 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 445.4491 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 445.4491 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 224.187 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 434.2378 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 433.9878 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 422.7765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 433.9878 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 422.7765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 433.9878 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 422.7765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 422.5265 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 411.3152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 422.5265 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 411.3152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 422.5265 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 411.3152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 411.0652 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 71.1161 399.854 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 411.0652 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 156.1555 399.854 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 411.0652 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 292.2185 399.854 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 399.604 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 156.1555 399.604 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 224.187 399.604 cm 0 0 m 68.281 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 103.392 465.4796 Tm (\032\003\002\006)Tj 8.434 0.717 Td (\200\006\002\240\002\f\202\t\003\r\f\001\b\002\217\003\001 \002\212\r\006\ \004\204\t\005)Tj 1.552 -1.434 Td (\032\224\241)Tj 8.504 0 Td (\032\224+)Tj /T1_0 1 Tf -22.171 -1.433 Td (Lee et al.)Tj 11.86 0 Td (55,56)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (33,30)Tj 8.504 0 Td (61,40)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (56,55)Tj -20.364 -1.433 Td (Shichijo et al.)Tj 11.236 0 Td (86,0)Tj /Span<>> BDC ( )Tj EMC (\(78,3\22693,7\))Tj 8.504 0 Td (86,1)Tj /Span<>> BDC ( )Tj EMC (\(77,7\22694,5\))Tj -19.74 -1.433 Td (Zhang et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Shi et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -16.414 -1.433 Td (Zheng et al.)Tj 16.414 0 Td (\203\036\021 \007\026\027\027\t\b)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.132 Tw 9 0 0 9 303.3071 730.483 Tm [(\020\004\206\f\t\204\004 )0.6(4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\206\020\024\033\032\027\030\027\f\027\025\022\027 )0.6(\025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 )0.7(\033\031)]TJ /Span<>> BDC ( )Tj EMC 20.507 0 Td (\f\031\n\020\f\022\016\020)Tj 0 Tw (-)Tj -20.507 -1.2 Td (\006\022\t\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(n)-2.3(e)-10.4(o)-5.3(p)-4.9(l)-1.1(a)-7.2(s)5.1(m)3.2(s b)-2.3(y l)-1.6(o)-12.5(c)3.2(a)-9.2(t)-29(i)-1.4(o)-4(n)]TJ ET /GS2 gs q 1 0 0 1 303.3071 704.381 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 691.778 cm 0 0 m 0 12.353 l S Q q 1 0 0 1 354.5807 704.381 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 692.028 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 439.6201 704.381 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 524.6594 692.028 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 303.5571 679.4249 cm 0 0 m 0 12.353 l S Q q 1 0 0 1 354.3307 691.778 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 354.5807 679.4249 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 439.6201 691.778 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 679.4249 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 524.6594 679.4249 cm 0 0 m 0 12.103 l S Q q 1 0 0 1 303.3071 679.1749 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 354.5807 679.1749 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 439.6201 679.1749 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 524.6594 618.8298 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 303.3071 618.5798 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 354.5807 618.5798 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 439.6201 618.5798 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 524.6594 558.2346 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 303.3071 557.9846 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 354.5807 557.9846 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 439.6201 557.9846 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 524.6594 507.2395 cm 0 0 m 0 50.495 l S Q q 1 0 0 1 303.3071 506.9895 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 494.6443 cm 0 0 m 0 12.095 l S Q q 1 0 0 1 354.5807 506.9895 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 494.6443 cm 0 0 m 0 12.095 l S Q q 1 0 0 1 439.6201 506.9895 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 524.6594 494.6443 cm 0 0 m 0 12.095 l S Q q 1 0 0 1 303.3071 494.3943 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 303.5571 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 354.5807 494.3943 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 354.5807 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 439.6201 494.3943 cm 0 0 m 85.289 0 l S Q q 1 0 0 1 439.6201 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 524.6594 434.0492 cm 0 0 m 0 60.095 l S Q q 1 0 0 1 303.3071 433.7992 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 354.5807 433.7992 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 439.6201 433.7992 cm 0 0 m 85.289 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 318.825 688.878 Tm (\032\003\002\006)Tj 8.255 0.788 Td (\035\002\220\004\f\t\213\004\204\t\235 \b\002\002\002\206\006\004\213\002\ \004\b\t\005)Tj 0.669 -1.575 Td (\032\224\241)Tj 10.63 0 Td (\032\224+)Tj /T1_0 1 Tf -21.108 -1.574 Td (Lee et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 30% )Tj 3.887 -1.2 Td (\(15\))Tj -3.629 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 36% )Tj 3.629 -1.2 Td (\(18\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 34% )Tj 3.686 -1.2 Td (\(17\))Tj 6.743 6 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 40% )Tj 3.887 -1.2 Td (\(20\))Tj -3.629 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 28% )Tj 3.629 -1.2 Td (\(14\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 32% )Tj 3.686 -1.2 Td (\(16\))Tj -21.099 -1.574 Td (Shichijo et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 52% )Tj 3.887 -1.2 Td (\(99\))Tj -3.629 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 15% )Tj 3.629 -1.2 Td (\(28\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 33% )Tj 3.686 -1.2 Td (\(61\))Tj 6.743 6 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 53% )Tj 3.637 -1.2 Td (\(101\))Tj -3.379 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 18% )Tj 3.629 -1.2 Td (\(35\))Tj -3.686 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 29% )Tj 3.686 -1.2 Td (\(56\))Tj -21.099 -1.574 Td (Zhang et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 25% )Tj 3.887 -1.2 Td (\(27\))Tj -3.99 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\026\016 )Tj 1.961 -1.2 Td (\022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 75%)Tj 2.029 -1.2 Td (\(80\))Tj 6.743 4.8 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 24% )Tj 3.887 -1.2 Td (\(26\))Tj -3.99 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\026\016 )Tj 1.961 -1.2 Td (\022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 76%)Tj 2.029 -1.2 Td (\(81\))Tj -21.099 -1.574 Td (Shi et al.)Tj 14.288 0 Td (\203\036\021 \007\026\027\027\t\b)Tj -14.288 -1.574 Td (Zheng et al.)Tj 6.582 0 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 39% )Tj 3.637 -1.2 Td (\(103\))Tj -3.379 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 42% )Tj 3.379 -1.2 Td (\(111\))Tj -3.436 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 19% )Tj 3.686 -1.2 Td (\(50\))Tj 6.743 6 Td (\215\030\026\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 39% )Tj 3.637 -1.2 Td (\(103\))Tj -3.379 -1.2 Td (\214\036\r\t\036 \024\021\007\036\035\t)Tj /Span<>> BDC ( )Tj EMC (\227 41% )Tj 3.379 -1.2 Td (\(109\))Tj -3.436 -1.2 Td (\215\030\016\n\026\016 \022\017\001\022\026)Tj /Span<>> BDC ( )Tj EMC (\227 20% )Tj 3.686 -1.2 Td (\(56\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 303.3071 417.0798 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \025\031\021\031\031\ \240\032\020\016\031\021\020\025\022\235 \033\031)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\026\027\032\020\026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.323 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(n)-2.3(e)-10.4(o)-5.3(p)-4.9(l)-1.1(a)-7.2(s)5.1(m)3.2(s b)-2.3(y s)-12.5(i)7.9(z)7.9(e)]TJ ET /GS2 gs q 1 0 0 1 303.3071 401.7779 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 388.6078 cm 0 0 m 0 12.92 l S Q q 1 0 0 1 371.5886 401.7779 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 388.8578 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 448.124 401.7779 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 524.6594 388.8578 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 303.5571 375.6879 cm 0 0 m 0 12.92 l S Q q 1 0 0 1 371.3386 388.6078 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 371.5886 375.6879 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 448.124 388.6078 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 375.6879 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 524.6594 375.6879 cm 0 0 m 0 12.67 l S Q q 1 0 0 1 303.3071 375.4379 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 375.4379 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 375.4379 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 362.5258 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 362.2758 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 362.2758 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 362.2758 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 349.3637 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 349.1137 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 371.5886 349.1137 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 448.124 349.1137 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 524.6594 288.2016 cm 0 0 m 0 60.662 l S Q q 1 0 0 1 303.3071 287.9516 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 287.9516 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 287.9516 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 275.0396 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 274.7896 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 303.5571 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 371.5886 274.7896 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 371.5886 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 448.124 274.7896 cm 0 0 m 76.785 0 l S Q q 1 0 0 1 448.124 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 524.6594 261.8775 cm 0 0 m 0 12.662 l S Q q 1 0 0 1 303.3071 261.6275 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 371.5886 261.6275 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 448.124 261.6275 cm 0 0 m 76.785 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 327.3289 385.7079 Tm (\032\003\002\006)Tj 9.534 0.823 Td (\022\004\213\214\r\006 \b\002\002\002\206\006\004\213\002\004\b\t\005)Tj -0.079 -1.646 Td (\032\224\241)Tj 9.567 0 Td (\032\224+)Tj /T1_0 1 Tf -21.64 -1.645 Td (Lee et al.)Tj 10.515 0 Td (20,42)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (8,22)Tj 9.567 0 Td (20,56)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (8,90)Tj -20.082 -1.645 Td (Shichijo et al.)Tj 10.669 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(20\22660\))Tj 9.567 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(20\22660\))Tj -20.236 -1.645 Td (Zhang et al.)Tj 9.424 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (10 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 17,8% )Tj 2.639 -1.2 Td (\(19\))Tj -3.05 -1.2 Td (10\22620)Tj /Span<>> BDC ( )Tj EMC (\n\n)Tj /Span<>> BDC ( )Tj EMC (\227 60,7% )Tj 3.05 -1.2 Td (\(65\))Tj -2.639 -1.2 Td (>)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 21,5% )Tj 2.639 -1.2 Td (\(23\))Tj 6.928 6 Td (<)Tj /Span<>> BDC ( )Tj EMC (10 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 20,5% )Tj 2.639 -1.2 Td (\(22\))Tj -3.05 -1.2 Td (10\22620 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 56,1% )Tj 3.05 -1.2 Td (\(60\))Tj -2.639 -1.2 Td (>)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj /Span<>> BDC ( )Tj EMC (\227 23,4% )Tj 2.639 -1.2 Td (\(25\))Tj -21.63 -1.645 Td (Shi et al.)Tj 11.379 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj 9.567 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (20 \n\n)Tj -20.946 -1.645 Td (Zheng et al.)Tj 10.968 0 Td (10\22620 \n\n)Tj 9.567 0 Td (10\22620 \n\n)Tj ET q 70.866 122.703 453.543 123.344 re W n q /GS0 gs 453.543294 0 0 123.3445784 70.8661499 122.7032427 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.048 Tw 9 0 0 9 70.8661 111.7701 Tm [(\022\t\217\210\b\002\220 )0.5(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \220\032\027\021\031\021\022\030\025\013\235 )0.6(\b\032\020\203\022\n )0.5(\026\027\023\020\020\025\020\f\022\016\020: )0.5(\021\f\022\t\025\022\027 )0.5(\020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\031\235 )0.5(\033\032\031\203\022\f\020\n\023\022\n\022 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 40.536 0 Td (\032\020\016\021\022\023\022\027 \033\031\024\023\n\031\020\b\r\f\t)Tj 0 Tw (-)Tj -40.536 -1.2 Td [(\006\022\031\025\025\031\b\031 \024\022\025\030\032\031\026\020 \033\031\ \024\f\027 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\b\031 \r\ \030\020\f\027\025\022\t \204\033\022\023\027\f\022\020\f\017\025\013)0.6(\200 \025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\031\ \f\024\023\031\235 \n\022\213\n\022)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.037 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC 5.485 0 Td [(ef)-40(fect of)]TJ /Span<>> BDC ( )Tj EMC [(antibacter)-37(ial )0.5(p)46(roph)12(ylaxis )0.5(on )0.5(the)]TJ /Span<>> BDC ( )Tj EMC [(dev)13(elopment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 22.121 0 Td [(postcoagulation )0.5(syndrome af)-46(ter )0.5(endoscopic )0.5(remov)16(al )0.5(of)]TJ /Span<>> BDC ( )Tj EMC (epi)Tj 0 Tw (-)Tj -27.606 -1.2 Td [(thelial neoplas)33.1(ms of)]TJ /Span<>> BDC ( )Tj EMC (the colon)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.7153 56.0378 Tm (152)Tj ET endstream endobj 532 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;   %%#(((((#,0000,7;;;7;;;;;;;;;;<""  ^C !"#$%&'()*123456789:ABCDEFGHIJQRSTUVWXYZabcdefghijqrstuvwxyzk!1AQa"q2$BRc#br %&'()*3456789:CDEFGHIJSTUVWXYZdefghijstuvwxyz?"" 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"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" endstream endobj 583 0 obj <>stream endstream endobj 529 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-10(\026\n\r\017 \224\025\016)-9.9(\026\r)10(\025\017\013)-20(\002\020\213\n\025\t\t\025\013)10.1(\025 )]TJ 0 -1 TD [(\016\n\t\202\005\025\024\017 \224\005\n\022\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 \002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\ \b\017\t\n\221 )]TJ T* [(\026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n \(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022\025\255\212\025\005\022\n\022\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 36.366 2 Td [(Antibacterial pr)31.1(e)10.9(v)12(ention of\022postcoagulation s)10(yndr)20(ome during )]TJ -2.695 -1 Td [(endoscopic r)31(emov)10(al of\022colon neoplasms \(r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.777 Tw 10 0 0 10 42.5197 724.8299 Tm (\024\006\036\027\017\r\026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 I)Tj 0 Tw 5.83 0 0 5.83 163.901 728.1599 Tm (2)Tj 0.777 Tw 10 0 0 10 166.816 724.8299 Tm (-\021\036\f\021\026. \222\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.405 Tw -12.43 -1.218 Td (\027\026\004\017\n\024\005 \020\036\021\036\030\024\020\036\027\027\024\ \f\021\034 \f\004\017\021\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (I)Tj 0 Tw 5.83 0 0 5.83 222.3973 715.9819 Tm (2)Tj 0.405 Tw /Span<>> BDC 10 0 0 10 225.3123 712.6519 Tm ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (50%. )Tj 0.492 Tw -18.279 -1.218 Td (\222\021\026\021\017\f\021\017\004\036\f\022\031\033 \024\002\030\026\002\ \024\021\022\031 \007\026\027\027\t\b, \023\030\024\r\036\030\022\031 \030\ \017)Tj 0 Tw (-)Tj 0.484 Tw 0 -1.218 TD (\f\022\026 \f\n\036\013\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\036\027\017\036 \007\017\026\020\030\026\n\n\t \023\ \030\024\r\024)Tj 0 Tw (-)Tj 0.275 Tw T* (\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\026\n\n\036 R)13(ev)-16(iew Mana)-16.9(ger \(R)13(evMan\) 5.4.1 )]TJ 0 Tw T* [(\(Co)-16(chr)-33(ane coll)-15.9(abor)-33(a)15(t)-32(ion sof)-27.9(t)-32(w)-12(ar)-23.9(e\) \(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC (2\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 627.4059 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.717 Tw 10 0 0 10 42.5197 603.0499 Tm (\215\030\024\026\027\026\035\017\017\030\024\r\026\027\t \030\036\031\035\ \034\021\026\021\t \220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\ \024 )Tj -0.056 Tw T* (\031\007\026\035\036\027\017\016 \220\023\017\021\036\035\017\026\035\034\ \027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \031)Tj /Span<>> BDC ( )Tj EMC (1055)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj -0.057 Tw T* (\006\017\036\027\021\024\r, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \020\036\021\036\030\024\020\036\027\027\024\f\021\ \017 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.069 Tw 0 -1.218 TD (\007\024\r\026\027\017\005 I)Tj 0 Tw 5.83 0 0 5.83 84.0709 569.8458 Tm (2)Tj 0.069 Tw /Span<>> BDC 10 0 0 10 86.9859 566.5158 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (80% \023\024\035\031\004\036\027\t \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\036 )Tj 0.023 Tw -4.447 -1.218 Td (\030\026\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\036\027\017\017 \f\035\031\004\026\036\r \030\026\ \r\017\021\017\016 \023\024\f\021\022\024\026\020\031)Tj 0 Tw (-)Tj -0.025 Tw 0 -1.218 TD (\035\016\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \r\027\031\021\030\017\r\036\027\027\ \024\005 )Tj 0.182 Tw T* (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\017 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,30; 95% )Tj 0 Tw T* (\212\230: 0,09\2260,96, )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\) \(\217\017\f. 2\).)Tj 0.348 Tw T* [(\211\004\017\021\t\r\026\016, )0.6(\004\021\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.6(\r\022\035\033\004\036\027\027\t\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 19.877 0 Td (\n\036\021\026)Tj 0 Tw (-)Tj 0.529 Tw -19.877 -1.218 Td [(\026\027\026\035\017 )0.6(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036, )0.6(\023\030\024\017\r\036\007\036\027\026 )0.6(\024\006\036\027\022\026 )]TJ 0.15 Tw T* (\022\026\004\036\f\021\r\026 \007\026\027\027\t\b \017\f\f\035\036\007\024\ \r\026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\017\f\021\036\n\t )Tj -0.063 Tw T* [(C)13(ONSOR)-12(T. \215\024)]TJ /Span<>> BDC ( )Tj EMC 5.354 0 Td [(\030\036\031\035\034\021\026\021\026\n )0.5(\024\006\036\027\022\017 \022\026\004\036\f\021\r\026 )0.5(\002\t\035\024 \r\t\016\r)]TJ 0 Tw (-)Tj 0.054 Tw -5.354 -1.218 Td (\035\036\027\024 \027\026\035\017\004\017\036 \017\f\f\035\036\007\024\r\ \026\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\017\n \022\026\004\036\f\021\r\024\n, \004\021\024 )Tj -0.043 Tw T* (\016\r\035\016\036\021\f\016 \027\036\007\024\f\021\026\021\022\024\n \023\ \030\024\r\036\007\036\027\027\024\020\024 \n\036\021\026\026\027\026\035\ \017\026)Tj /Span<>> BDC ( )Tj EMC ([5].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 724.8299 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.103 Tw 10 0 0 10 274.9606 700.4739 Tm (\215\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 \f\017\ \027\007\030\024\n \(\215\025\222\) \023\024\f\035\036 \220\027\007\024\f\ \022\024)Tj 0 Tw (-)Tj -0.077 Tw T* (\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \007\017\f\f\036\022\006\017\017 \016\r\035\016\036\021\f\016 \024\f\035\ \024\032\027\036)Tj 0 Tw (-)Tj 0.058 Tw T* (\027\017\036\n, \b\026\030\026\022\021\036\030\017\031\033\013\017\n\f\016\ \r\024\f\023\026\035\017\021\036\035\034\027\024\005 \030\036\026\022\006\ \017\036\005 )Tj 0.123 Tw T* (\024\030\020\026\027\017\n\026, \r\024\027\017\022\026\033\013\036\005\ \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \023\024\r\030\036\032\007\036\027\ \017\016 )Tj 0.139 Tw T* (\f\021\036\027\022\017 \021\024\035\f\021\024\005 \022\017\001\022\017 \023\ \024\f\030\036\007\f\021\r\024\n \220\035\036\022\021\030\024\022\024\026\ \020\031\035\016)Tj 0 Tw (-)Tj 0.08 Tw 0 -1.218 TD (\006\017\017 \r\024 \r\030\036\n\016 \r\t\023\024\035\027\036\027\017\016\ \220\027\007\024\f\022\024\023\017\004\036\f\022\024\005 \023\024\007\f\ \035\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\017\f\021\024\005 \007\017\f\f\036\022\006\017\017.)Tj 1.155 Tw T* (\204\036\b\026\027\017\n \r\024\027\017\022\027\024\r\036\027\017\016 \ \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\024\020\024\ )Tj 0.028 Tw T* (\f\017\027\007\030\024\n\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\026 \027\036 \016\f\036\027, \017\n\036\036\021\f\016 \023\ \030\036\007\023\024\035\024\032\036\027\017\036, )Tj 0.194 Tw T* (\004\021\024 \021\036\030\n\017\004\036\f\022\024\036 \023\024\r\030\036\ \032\007\036\027\017\036 \n\t\001\036\004\027\024\005 \024\002\024\035\024\ \004\022\017 )Tj 0.066 Tw 0 -1.218 TD (\r\024 \r\030\036\n\016 \220\027\007\024\f\022\024\023\017\004\036\f\022\ \024\005 \030\036\036\022\006\017\017 \f\035\017\017\f\021\024\005 \024\ \002\024)Tj 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD [(\035\024\004\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.479 0 Td [(\n\017\022\030\024\002\017\024\021\026 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001\022\017, )0.5(\r\024\007\036\005\f\021\r\031\033\013\026\016 )]TJ 0.431 Tw -3.479 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\005 \007\036\ \235\036\022\021 \017\020\030\026\033\021 \022\035\033\004\036\r\031\033\ )Tj 0 Tw T* (\030\024\035\034 [6].)Tj 0.226 Tw 0 -1.218 TD [(\215\025\222 \031\f\021\026\027\026\r\035\017\r\026\036\021\f\016 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\035\017\004\017\017 )0.5(\035\024\022\026\035\017\024\r\026\027\027\024\005 )]TJ -0.024 Tw 0 -1.218 TD (\002\024\035\036\027\036\027\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, \f\024\024\021\r\ \036\021\f\021\r\031\033\013\036\005 )Tj 0.38 Tw 0 -1.218 TD (\n\036\f\021\031 \r\t\023\024\035\027\036\027\017\016 \220\027\007\024\f\ \022\024\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\ \024\005 )Tj 0.057 Tw 0 -1.218 TD (\007\017\f\f\036\022\006\017\017, \017)Tj /Span<>> BDC ( )Tj EMC (\235\036\002\030\017\035\034\027\024\005 \035\017\b\024\030\026\007\022\017\ \017\035\017 \023\024\r\t\001\036\027\017)Tj 0 Tw (-)Tj 0.239 Tw T* (\036\n \r\024\f\023\026\035\017\021\036\035\034\027\t\b \n\026\030\022\036\ \030\024\r \022\030\024\r\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\005\022\024\006\017\021\024\r. )Tj 0.234 Tw 0 -1.218 TD (\222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \023\024\f\035\036 \220\027\007\024\f\022\024\023\017\004\036\f\022\017\ \b \r\n\036)Tj 0 Tw (-)Tj 0.114 Tw 0 -1.218 TD (\001\026\021\036\035\034\f\021\r \024\006\036\027\022\026 \002\024\035\036\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \023\030\024\017\ )Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\r\024\007\017\021\f\016 \027\036 \030\026\027\036\036 \004\036\n \004\036\ \030\036 6 \004\026\f\024\r \023\024\f\035\036 \024\022\024\027\004\026\ \027\017\016 )Tj ET q 42.52 212.149 379.842 206.357 re W n q /GS0 gs 379.8425035 0 0 206.3578966 42.5196838 212.1486647 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 9 0 0 9 42.5197 201.2362 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\032\027\021\031 \033\031\022\024\n\020 \021)Tj /Span<>> BDC ( )Tj EMC (\240\020\016\027 \030\020\025\025\013\200 MedLine)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( Search in the)Tj /Span<>> BDC ( )Tj EMC [(MedLine d)26.2(atabase)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 -1.83 TD (\034\213 \217\003\004\003\r\005 \t\213\f\r\201\r\b\013 \240\004\b\b\013\ \r:)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 169.4649 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 105.1319 169.4649 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 136.313 169.4649 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 193.0059 169.4649 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 148.3957 cm 0 0 m 0 20.819 l S Q q 1 0 0 1 249.6988 169.4649 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 148.6457 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 314.8957 169.4649 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 380.0925 169.4649 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 148.6457 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 148.6457 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.7697 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 105.1319 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 136.313 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 193.0059 137.1765 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 249.4488 148.3957 cm 0 0 m 65.447 0 l S Q q 1 0 0 1 249.6988 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 148.3957 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 380.0925 148.3957 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 137.1765 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 136.9265 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 136.9265 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 136.9265 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 136.9265 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 136.9265 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 136.9265 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 136.9265 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 125.7152 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 125.4652 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 125.4652 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 125.4652 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 125.4652 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 125.4652 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 125.4652 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 125.4652 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 114.2539 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 114.0039 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 114.0039 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 114.0039 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 114.0039 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 114.0039 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 114.0039 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 114.0039 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 102.7926 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 102.5426 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 102.5426 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 102.5426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 102.5426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 102.5426 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 102.5426 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 102.5426 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 91.3314 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 91.0814 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 42.7697 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 105.1319 91.0814 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 105.1319 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 136.313 91.0814 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 136.313 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 193.0059 91.0814 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 91.0814 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 249.6988 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 91.0814 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 380.0925 91.0814 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 380.0925 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 79.8701 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 79.6201 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 105.1319 79.6201 cm 0 0 m 31.181 0 l S Q q 1 0 0 1 136.313 79.6201 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 193.0059 79.6201 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 249.6988 79.6201 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 314.8957 79.6201 cm 0 0 m 65.197 0 l S Q q 1 0 0 1 380.0925 79.6201 cm 0 0 m 116.47 0 l S Q BT 0 0 0 1 k /GS1 gs /T1_4 1 Tf 8 0 0 8 63.7069 150.2957 Tm (\032\003\002\006)Tj 6.363 0 Td (\027\002\240)Tj 5.498 0.6 Td (\020\t\212)Tj -2.304 -1.2 Td (\t\217\217\f\r\240\002\004\b\t\235)Tj 9.391 1.2 Td (\020\t\212)Tj -1.35 -1.2 Td (\002\212\r\006\004\204\t\t)Tj 12.135 1.917 Td (\030\004\217\003\002\003\004)Tj -1.296 -1.2 Td (\006\004\213\t\003\t\235 \200\021\255)Tj 15.803 0.6 Td (\032\b\003\t\206\t\002\003\t\220)Tj -17.775 -2.034 Td (\032\224\241)Tj 8.15 0 Td (\032\224+)Tj /T1_1 1 Tf -36.876 -1.433 Td (Lee et al.)Tj 8.39 0 Td (2017)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.861 0 Td (ESD)Tj 6.032 0 Td (8/50)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 8.4 0 Td (1/50)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.547 0 Td (\202\n\023\017\006\017\035\017\027/\f\031\035\034\002\026\022\021\026\n)Tj -44.196 -1.433 Td (Shichijo et al.)Tj 8.39 0 Td (2021)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.861 0 Td (ESD)Tj 5.439 0 Td (14/188)Tj /Span<>> BDC ( )Tj EMC (\(7,5%\))Tj 8.4 0 Td (9/192)Tj /Span<>> BDC ( )Tj EMC (\(4,7%\))Tj 9.14 0 Td (\202\n\023\017\006\017\035\017\027/\f\031\035\034\002\026\022\021\026\n)Tj -44.196 -1.433 Td (Zhang et al.)Tj 8.39 0 Td (2015)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 6.54 0 Td (ESD)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (EMR)Tj 6.853 0 Td (45/107)Tj /Span<>> BDC ( )Tj EMC (\(42%\))Tj 8.307 0 Td (8/107)Tj /Span<>> BDC ( )Tj EMC (\(7,5%\))Tj 11.431 0 Td (\037\036\235\031\030\024\022\f\017\n)Tj -46.487 -1.433 Td (Shi et al.)Tj 8.39 0 Td (2016)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.774 0 Td (EMR)Tj 6.369 0 Td (2/38)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 8.15 0 Td (0/77)Tj /Span<>> BDC ( )Tj EMC (\(0%\))Tj 7.429 0 Td (\214\036\r\024\235\035\024\022\f\026\006\017\027, \006\036\235\021\026\017\ \007\017\n)Tj -43.078 -1.433 Td (Zheng et al.)Tj 8.39 0 Td (2022)Tj 4.967 0 Td (\217\026\027\007\024\n)Tj 7.774 0 Td (EMR)Tj 5.619 0 Td (13/126)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 8.15 0 Td (14/120)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 12.053 0 Td (\037\036\235\017\022\f\017\n)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 504.6022 56.0378 Tm (151)Tj ET endstream endobj 530 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;c   I-!1"AQUV25aqu#3BS&RT $%'()*46789:CDEFGHIJWXYZbcdefghijrstvwxyz⳴?iJR)JR)JT>vfڋYrKqjQSjz'y+=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNIm:'yh{ԟӫ=RGNImwlչ:{ERTz8 Ҕ)JR)JR)JR)JR)JRiJR)JR)JUCo}J})JR)JR)JR#%D;&P.6Vpxcðk)JR*[{?[JR)JR)JR)JR)JR)@iJR)JR)JUCo}J})JRJNRDW0A UfX`(GzՕu|ԄU 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A)-12.6(n)-17.3(t)-46.2(i)-5.9(b)-17.7(a)-11.1(c)-41.5(t)-24.7(e)-12.1(r)-56.4(i)-5.1(a)-11.4(l p)-13.7(r)-19.1(e)-15.8(v)-18.7(e)-11.5(n)-17.3(t)-46.2(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-22.3(o)-15.8(s)-29.3(t)-22.4(c)-6.5(o)-18.2(a)-10.8(g)-9.5(u)-8.4(l)-37.8(a)-18.2(t)-46.2(i)-6.8(o)-9.2(n s)-30.8(y)-27.5(n)-14.5(d)-10.4(r)-15.8(o)-9.2(m)-16.6(e)23( )]TJ 0.252 Tw -6.621 -1.2 Td [(d)-8.9(u)-7.6(r)-56.4(i)-3.2(n)-11.9(g )0.5(e)-11.5(n)-14.5(d)-11.1(o)-15.8(s)-17.7(c)-6.5(o)-8.3(p)-18.6(i)-5(c )0.5(r)-19.1(e)-11.5(m)-12.4(o)-10.3(v)-28.3(a)-11.4(l )0.5(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC 14.053 0 Td [(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n )0.5(n)-16.1(e)-21(o)-8.3(p)-20.1(l)-37.8(a)-26.6(s)-6.6(m)-11.6(s )0.5(\()39.2(r)-19.1(e)-15.8(v)-51.7(i)-11(e)-12.5(w )0.5(a)-7.6(n)-14.5(d )0.5(m)-16.6(e)-22.3(t)-36.8(a)-19.6(-)-13.1(a)-7.6(n)-7.8(a)-11.4(l)-8.3(y)-28.9(s)-26.1(i)-7.4(s)41.5(\))10.4(. )]TJ /T1_2 1 Tf 0.033 Tc -0.033 Tw 20.988 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_1 1 Tf 0.023 Tc 0.252 Tw 7.019 0 Td [( )0.5(2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)12.5(4)16.3(9)-22.6(\226)50.8(1)0.9(55)6.9(. )0.5(\()-0.9(i)-3.2(n )0.5(R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(.)23( )]TJ -0.023 Tw -42.061 -1.2 Td [(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.1(1)26.9(-)55.1(1)12.5(4)16.3(9)-23.6(-)55.1(1)0.9(55)]TJ /T1_0 1 Tf 0.01 Tc 0.046 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_2 1 Tf 0 Tc 0.051 Tw 10.632 0 Td ( \004\031\b\031\024\031\021 \001\022\n\031\f\020\235 \205\027\032\b\027\027\ \021\022\007, \214\216\221\210 \253\001\215\002\037 \n\031\f\031\033\032\ \031\n\023\031\f\031\b\022\022 \022\026\027\025\022 \003.\001.)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 )Tj 0.023 Tw -10.637 -1.2 Td (\003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: kolia\ .pogosov@yandex.ru)Tj /T1_0 1 Tf 0.01 Tc 0.169 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_2 1 Tf 0 Tc 0.174 Tw 14.353 0 Td [( Nik)13.1(olay S. P)15(ogosov)63(, Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46.1(roctology)42(, Salyama Adilya st., 2, )]TJ 0.023 Tw -14.358 -1.2 Td [(Moscow)52(,123423, R)22.1(ussia; e-mail: k)13(olia.pogosov@yande)-14.8(x.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 22.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 22.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 590.8719 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.146 Tw 10 0 0 10 70.8661 566.5159 Tm (\203\026\017\002\024\035\036\036 \004\026\f\021\t\n \024\f\035\024\032\027\ \036\027\017\036\n \023\024\f\035\036 \220\027\007\024\f\022\024\023\017\ \004\036)Tj 0 Tw (-)Tj 0.279 Tw 0 -1.218 TD (\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005 \007\017\f\f\036\ \022\006\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \220\023\017\021\036\035\017)Tj 0 Tw (-)Tj 0.26 Tw T* (\026\035\034\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\005\ \021\024\035\f\021\024\005 \022\017\001\022\017 \030\026\n\036\030\024\ \n )Tj 0.085 Tw T* [(\002\024\035\036\036 )0.5(30 \n\n)]TJ /Span<>> BDC ( )Tj EMC [(\227 \016\r\035\016\036\021\f\016 )0.5(\023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\027\t\005 )0.6(\f\017\027\007)]TJ 0 Tw (-)Tj 0.363 Tw T* (\030\024\n \(\215\025\222\). \215\030\024\016\r\035\036\027\017\016 \007\ \026\027\027\024\020\024 \f\017\027\007\030\024\n\026 \f\b\024\032\017 )Tj 0.445 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \022\026\030\021\017\027\024\005\ \023\036\030\017\021\024\027\017\021\026, \r\t\r\026\027\027\024\020\024\ )Tj -0.017 Tw T* (\023\036\030\235\024\030\026\006\017\036\005 \023\024\035\024\020\024 \024\ \030\020\026\027\026, \004\021\024 \023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\017\033 \027\036\024\002\024\f\027\024\r\026\027\027\t\b \007\017\026\ \020\027\024\f\021\017\004\036\f\022\017\b \017\f\f\035\036\007\024\r\026\ \027\017\005 )Tj 0.142 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\033 \026\022\021\017\r\027\024\005 \035\ \036\004\036\002\027\024\005 \021\026\022\021\017\022\017, \r\022\035\033\ \004\026)Tj 0 Tw (-)Tj 0.151 Tw T* [(\033\013\036\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.578 0 Td [(\f\036\002\016 )0.5(\r\t\023\024\035\027\036\027\017\036 )0.6(\023\024\035\024\f\021\027\t\b )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\b )]TJ 0 Tw -3.578 -1.218 Td (\r\n\036\001\026\021\036\035\034\f\021\r [1].)Tj 0.386 Tw T* (\222\024\020\035\026\f\027\024 \026\027\026\035\017\031 \030\036\031\035\ \034\021\026\021\024\r 1000 \220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj 0.226 Tw T* (\f\022\017\b \007\017\f\f\036\022\006\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036, \215\025\222 \030\ \026\r\017\035)Tj 0 Tw (-)Tj 0.183 Tw T* (\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (13,6%)Tj /Span<>> BDC ( )Tj EMC ([2]. \204\036\007\017\026\027\027\024\036 \022\024\035\017\004\036\f\021\ \r\024 \022\024\005\022\024-\007\027\036\005, )Tj 0.264 Tw T* (\023\030\024\r\036\007\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \220\027\007\024)Tj 0 Tw (-)Tj 0.469 Tw T* (\f\022\024\023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\ \024\005 \007\017\f\f\036\022\006\017\017, \f\024\f\021\026\r\035\016\036\ \021 )Tj 0.189 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\007\027\036\005, \024\007\027\026\022\024 \023\030\024\016\r\035\036\027\ \017\016 \215\025\222 \023\030\017\r\024\007\016\021 \022)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017)Tj 0 Tw (-)Tj 0.199 Tw T* (\004\036\027\017\033 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\017 \020\024\f\023\017\021\026\035\017\026\006\017\017 \023\026\ \006\017\036\027)Tj 0 Tw (-)Tj 0.091 Tw T* (\021\026, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n, \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \007\027\016, \004\021\024 \023\024\r\t\001\026\036\021 \f\021\024\017\ \n\024\f\021\034 \036\020\024 )Tj 0 Tw T* (\035\036\004\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([3].)Tj 0.03 Tc 0.019 Tw T* [(\200 )0.5(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 )0.5(\024\021\f\031\021\f\021\r\031\036\021 )0.5(\036\007\017\027\026\016 )0.5(\022\024\027\006\036\023\006\017\016)30( )]TJ 0.033 Tw T* (\023\026\021\024\020\036\027\036\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\235\017\035\026\022\021\017\022\017 \007\026\027\027\024\020\ \024 \024\f\035\024\032\027\036\027\017\016.)30( )]TJ 0.037 Tw T* [(\213\007\017\027\f\021\r\036\027\027\t\n \017\r\036\f\021\027\t\n \n\036\ \021\024\007\024\n \b\017\030\031\030\020\017\004\036\f\022\024\005)30( )]TJ 0.134 Tw T* (\023\030\024\235\017\035\026\022\021\017\022\017 \016\r\035\016\036\021\f\ \016 \022\035\017\023\017\030\024\r\026\027\017\036 \023\024\f\035\036\024\ \023\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.152 Tw T* (\030\026\006\017\024\027\027\024\020\024 \007\036\235\036\022\021\026, \r\ \n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\036\n, \023\030\024\r\036\007\036\027\027\t\005)30( )]TJ 0.195 Tw T* [(L)-32(iu \f)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \n\036\021\026\026\027\026\035\017, \r\022\035\033\004\ \026\r\001\017\005 477 \023\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.309 Tw T* (\036\027\021\024\r, \027\036 \r\t\016\r\017\035 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\024\005 \030\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.38 Tw T* (\027\017\006\t \r)Tj /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036 \030\026\r\017\021\017\016 \023\024\f\021\022\ \024\026\020\031\035\016\006\017\024\027\027\024\020\024)30( )]TJ 0.271 Tw T* (\f\017\027\007\030\024\n\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \020\030\031\023\023 \f)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.18 Tw T* (\f\022\017\n \022\035\017\023\017\030\024\r\026\027\017\036\n \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\020\024 \210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,75 95%)30( )]TJ 0.022 Tw T* [(\212\230: )0.5(\(0,26\2262,18\), )]TJ /T1_2 1 Tf 0 Tc 0 Tw (p)Tj /T1_1 1 Tf 0.03 Tc 0.022 Tw /Span<>> BDC 7.896 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.099 0 Td [(0,6 )0.5([4]. \211\004\017\021\t\r\026\016, \004\021\024 )0.5(\007\026\027\027\t\005)30( )]TJ 0.186 Tw -8.995 -1.218 Td [(\f\017\027\007\030\024\n \f\024\023\030\024\r\024\032\007\026\036\021\f\016\ \023\030\017\027\026\022\026\n\017 \f\017\f\021\036\n\027\024\005)30( )]TJ 0.051 Tw T* [(\r\024\f\023\026\035\017\021\036\035\034\027\024\005 )0.5(\030\036\026\022\006\017\036\005 )0.5(\024\030\020\026\027\017\n\026, )0.5(\023\030\036\007\023\030\017\027\017)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.19 Tw T* (\n\026\035\017\f\034 \023\024\023\t\021\022\017 \023\030\024\r\036\007\036\ \027\017\016 \026\027\021\017\002\017\024\021\017\022\024\023\030\024\235\ \017)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.13 Tw T* [(\035\026\022\021\017\022\017 )0.6(\007\026\027\027\024\020\024 )0.5(\f\017\027\007\030\024\n\026. )0.5(\210\007\027\026\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.241 0 Td [(\035\017\021\036\030\026\021\031\030\036)30.1( )]TJ 0.364 Tw -17.241 -1.218 Td [(\017\n\036\033\021\f\016 )0.5(\023\030\024\021\017\r\024\030\036\004\017\r\t\036 )0.5(\007\026\027\027\t\036 )0.5(\024\021\027\024\f\017\021\036\035\034\027\024)30( )]TJ 0.495 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 \023\030\024\235\017\035\ \026\022\021\017\004\036\f\022\024\020\024 \027\026\027\026\004\036\027\ \017\016)30( )]TJ 0.704 Tw T* [(\026\027\021\017\002\017\024\021\017\022\024\r )0.5(\023\036\030\036\007 )0.5(\r\t\023\024\035\027\036\027\017\036\n )0.5(\007\017\f\f\036\022\006\017\017)30( )]TJ 0.079 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036. \215\030\017\027\ \017\n\026\016 \r\024 \r\027\017\n\026\027\017\036 \007\024)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.482 Tw T* [(\f\021\026\021\024\004\027\024\036 \022\024\035\017\004\036\f\021\r\024 \ \017\f\f\035\036\007\024\r\026\027\017\005, \023\030\024\r\036\007\036\027\ )30( )]TJ 0 Tw T* (\n\036\021\026\026\027\026\035\017 \007\026\027\027\t\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 303.3769 590.8719 Tm [(\207)21(\026)45(\024\034\033\031\026)-10(\r\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.178 Tw 10 0 0 10 303.3071 566.5159 Tm (\204\036\021\026\026\027\026\035\017 \r\t\023\024\035\027\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026)Tj 0 Tw (-)Tj 0.171 Tw T* [(\006\017\016\n\017 )0.6(\253T)47(he )0.6(p)25(r)-24(efer)-24(r)-23.9(ed )0.6(r)-24(epor)-22(t)-32(ing )0.6(i)-24(tems )0.6(for )0.6(sy)-13(stema)15.1(t)-32(ic )]TJ 0.163 Tw T* [(r)-24(ev)-15.9(iews )0.5(and me)-11.9(t)15(a-anal)35(y)-13(ses )0.5(\(PRISMA\)\273. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 17.372 0 Td (\n\036\021\026\026\027\026\035\017 )Tj 0.486 Tw -17.372 -1.218 Td (\r\022\035\033\004\036\027\t \023\024\035\027\024\021\036\022\f\021\024\r\ \t\036 \f\021\026\021\034\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n )Tj 0.271 Tw T* (\016\t\022\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \024\021\030\026\032\036\027\024 \030\026\r\017\ \021\017\036 \023\024\f\021\022\024\026\020\031\035\016)Tj 0 Tw (-)Tj 0.196 Tw T* (\006\017\024\027\027\024\020\024 \f\017\027\007\030\024\n\026 \023\024\f\ \035\036 \031\007\026\035\036\027\017\016 \220\023\017\021\036\035\017\026\ \035\034\027\t\b )Tj -0.007 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\ \024\005 \022\017\001\022\017 \023\031\021\036\n \220\027\007\024\f\022\024\ \023\017\004\036)Tj 0 Tw (-)Tj 0.002 Tw T* (\f\022\024\005 \007\017\f\f\036\022\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\f\035\017\017\f\021\024\n \f\035\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\n\031\022\024\220\022\021\024\n\017\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\ \030\024\235\017\035\026\022\021\017\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036 \027\036\036.)Tj 0.014 Tw T* [(\200 )0.5(\030\036\031\035\034\021\026\021\036 )0.5(\023\024\017\f\022\026 \r)]TJ /Span<>> BDC ( )Tj EMC 9.332 0 Td [(\002\026\036 )0.5(\007\026\027\027\t\b )0.5(P)20(ubMed \023\024)]TJ /Span<>> BDC ( )Tj EMC 10.033 0 Td (\026\023\030\024)Tj 0 Tw (-)Tj -0.027 Tw -19.365 -1.218 Td [(\f\031 \253end)-16(oscopic submucosal dissec)-16(t)-32(ion\273 \017)]TJ /Span<>> BDC ( )Tj EMC [(\253coa)-17(gul)-15.9(a)15(t)-32(ion )]TJ 0.204 Tw T* [(syndr)-32(ome\273 )0.5(\002\t\035\024 \027\026\005\007\036\027\024 )0.5(58 \017\f\f\035\036\007\024\r\026\027\017\005. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\b\024\007\036 )Tj 0.029 Tw T* (\023\030\024\r\036\007\036\027\017\016 \f\022\030\017\027\017\027\020\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\b \030\026\002\024\021 \r\t\007\036\035\036\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.055 Tw T* (50. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \017\f\022\035\033\004\036\027\t \ 48 \023\031\002\035\017\022\026\006\017\005, \023\024\f\r\016)Tj 0 Tw (-)Tj 0.056 Tw T* [(\013\036\027\027\t\b )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n\031 )0.5(\031\007\026\035\036\027\017\033 )0.5(\220\023\017\021\036\035\017\026\035\034\027\t\b )]TJ -0.029 Tw T* (\027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\ \024\005 \022\017\001\022\017, \021\036\b\027\017\004\036\f\022\017\n \026\ \f\023\036\022)Tj 0 Tw (-)Tj -0.002 Tw T* (\021\026\n \r\t\023\024\035\027\036\027\017\016 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\024\005 \023\024\007\f\035\017\017\f\021\024\005\ \007\017\f)Tj 0 Tw (-)Tj 0.049 Tw T* (\f\036\022\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \235\026\022\021\024\030\026\n \030\017\f\022\026 \030\ \026\r\017\021\017\016 \215\025\222 \023\024\f\035\036 )Tj 0.237 Tw T* [(\036\036 )0.5(\r\t\023\024\035\027\036\027\017\016. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 8.229 0 Td [(\030\036\031\035\034\021\026\021\036 )0.6(\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 )0.6(\023\024)]TJ 0 Tw (-)Tj 0.278 Tw -8.229 -1.218 Td (\017\f\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\017\002\035\017\024\020\030\026\235\017\004\036\f\022\017\n \007\026\ \027\027\t\n, \f\030\036\007\017 \r\022\035\033)Tj 0 Tw (-)Tj 0.163 Tw T* (\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017 \017\f\f\035\036\007\024\r\026\027\017\ \005 \002\t\035\024 \r\t\016\r\035\036\027\024 )Tj 0.363 Tw T* [(\007\024\023\024\035\027\017\021\036\035\034\027\024 )0.5(3)]TJ /Span<>> BDC ( )Tj EMC [(\023\031\002\035\017\022\026\006\017\017, )0.5(\023\024\f\r\016\013\036\027\027\t\036 )0.5(\026\027\021\017)]TJ 0 Tw (-)Tj 0.303 Tw T* (\002\026\022\021\036\030\017\026\035\034\027\024\005 \023\030\024\235\017\ \035\026\022\021\017\022\036 \023\024\f\021\022\024\026\020\031\035\016\006\ \017\024\027\027\024\020\024 )Tj 0.01 Tw T* (\f\017\027\007\030\024\n\026 \023\024\f\035\036 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\024\020\024 \031\007\026\035\036\027\017\016 \027\ \024\r\024\024\002)Tj 0 Tw (-)Tj 0.059 Tw T* (\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005 \022\017\001\022\ \017. \221\026\022\017\n \024\002\030\026\024\n, \r\022\035\033\004\036\ \027\024 )Tj 0 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \017\f\f\035\036\ \007\024\r\026\027\017\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.302 Tw T* (\215\030\017 \023\024\017\f\022\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\002\026\036 \007\026\027\027\t\b eL)-32(ibr)-33(ar)-24(y \035\017\021\036\030\026\021\031\030\027\t\b )]TJ 0.164 Tw T* (\017\f\021\024\004\027\017\022\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC [(\026\023\030\024\f\031 \253\023\024\f\021\022\024\026\020\031\035\016\006\ \017\024\027\027\t\005 )0.5(\f\017\027\007)]TJ 0 Tw (-)Tj 0.069 Tw T* (\030\024\n\273 \027\036 \027\026\005\007\036\027\024 \027\017 \024\007\027\ \024\005 \f\021\026\021\034\017, \022\024\021\024\030\026\016 \024\f\r\036\ \013\026\036\021 )Tj 0.257 Tw T* (\023\030\024\002\035\036\n\031 \030\026\r\017\021\017\016 \023\024\f\021\ \022\024\026\020\031\035\016\006\017\024\027\027\024\020\024 \f\017\027\007\ \030\024\n\026 )Tj 0.481 Tw T* [(\023\024\f\035\036 )0.5(\220\027\007\024\f\022\024\023\017\004\036\f\022\024\020\024 )0.7(\031\007\026\035\036\027\017\016 )0.5(\027\024\r\024\024\002\030\026\024\r\026)]TJ 0 Tw (-)Tj 0.143 Tw T* (\027\017\005 \021\024\035\f\021\024\005 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \036\020\024 \026\027\021\017\002\026\022\021\036\030\ \017\026\035\034\027\024\005 )Tj 0 Tw T* (\023\030\024\235\017\035\026\022\021\017\022\017.)Tj /T1_0 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.303 Tw 0 -1.218 TD (\222\031\n\n\026\030\027\024\036 \027\026\004\036\027\017\036 \007\017\b\ \024\021\024\n\017\004\036\f\022\017\b \007\026\027\027\t\b \024\023\017\ )Tj 0 Tw (-)Tj 0.088 Tw T* (\f\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \024\021\027\024\001\036\027\017\016 \001\026\027\f\024\r\ \(\210\231\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017)Tj 0 Tw (-)Tj 0.103 Tw T* (\021\036\035\034\027\t\n \017\027\021\036\030\r\026\035\024\n \(\212\230\ \). \210\231 \030\026\f\f\004\017\021\t\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.483 Tw T* [(\021\024\007\031 )0.5(Mantel\226Haenszel. )0.6(\212\035\016 )0.6(\n\036\021\026\026\027\026\035\017\026 )0.6(\r\024 \r\f\036\b )]TJ 0.141 Tw T* (\f\035\031\004\026\016\b \017\f\023\024\035\034\024\r\026\035\017 \n\024\ \007\036\035\034 \f\035\031\004\026\005\027\t\b \220\235\235\036\022\021\ \024\r. )Tj 0.126 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\031\033 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034 \f\030\036\007\017 \017\f\f\035\036\007\ \024\r\026\027\017\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ -53.418 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7153 56.0378 Tm (150)Tj ET endstream endobj 615 0 obj [619 0 R] endobj 616 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-10(\026\n\r\017 \224\025\016)-9.9(\026\r)10(\025\017\013)-20(\002\020\213\n\025\t\t\025\013)10.1(\025 )]TJ 0 -1 TD [(\016\n\t\202\005\025\024\017 \224\005\n\022\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 \002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\ \b\017\t\n\221 )]TJ T* [(\026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n \(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022\025\255\212\025\005\022\n\022\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 36.366 2 Td [(Antibacterial pr)31.1(e)10.9(v)12(ention of\022postcoagulation s)10(yndr)20(ome during )]TJ -2.695 -1 Td [(endoscopic r)31(emov)10(al of\022colon neoplasms \(r)31(e)11(vie)11(w and meta-analy)10(sis\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 388.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 388.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 351.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 351.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-149-155)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 131.3031 695.3259 Tm [(\f\t\026\n\255\017\r)-9.9(\026)11(\004\005\n\017\020\200\t\017\213 \224\005\025\216\n\020\017\r)-9.9(\026\n\r\017 )]TJ -3.998 -1.105 Td [(\224\025\016)-10(\026\r)10(\025\017\013)-19.9(\002\020\213\n\025\t\t\025\013)10(\025 \016\n\t\202\005\025\024\017 \224\005\n\022)-23.3(\237\t\202\025\016\r)10(\025\224\n\225\004\016\r)10(\025\024 )]TJ 2.223 -1.105 Td [(\002\202\017\020\004\t\n\n \t\025\b\025\025\255\005\017\212\025\b\017\t\n\ \221 \026)11(\025\020\016)-10(\026)11(\025\221 \r\n\204\r\n )]TJ 0 Tw 1.413 -1.105 Td [(\(\020\n\026)11(\004\005\017\026)-19.9(\002\005\t\217\221\022)-23.3(\025\255\212\025\005\022)-23.3(\n\022)-23.2(\024\004\026)11(\017\017\t\017\020\n\212\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 607.822 Tm [(\034\025\013)10(\025\016\025\b\022)-23.2(\007.\001.)]TJ 8.162 0 0 8.162 118.8231 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 123.459 607.822 Tm [(, \006\017\020\r\017\005\025\b\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 217.4055 612.484 Tm (1)Tj 0.023 Tw 14 0 0 14 222.0415 607.822 Tm [(, \035\n\r\002)-20(\026)11.1(\025\b\022)-23.3(\f)-31(.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 307.938 612.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 319.2587 607.822 Tm (, \007\017\212\017\005\025\b \030.\021.)Tj 0 Tw 8.162 0 0 8.162 406.4297 612.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 593.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 590.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 569.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 566.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 9 0 0 9 90.7087 547.6488 Tm (\037\036\035\034: \022\016\r\007\022\023\017 \204\203\203\027\n\023\022\021\ \025\031\024\023\017 \020\025\023\022\240\022\031\023\022\n\031\023\027\032\ \020\033\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\203\022\f\020\n\023\022\n\027 \033\031\024\023\n\031\020\b\r\ \f\t\006\022\031\025\025\031\b\031 \024\022\025\030\032\031\026\020.)Tj 0.01 Tw 0 -1.111 TD (\215\003\036\206\002\003\035\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \033\031\022\024\n \f\022\023\027\032\020\023\r\032\ \013 \022)Tj /Span<>> BDC ( )Tj EMC (\026\027\023\020\020\025\020\f\022\016 \033\032\031\022\016\021\031\030\022\ \f\024\t \021)Tj /Span<>> BDC ( )Tj EMC (\024\031\031\023\021\027\023\024\023\021\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\032\027\n\031\026\027\025\030\020\006\022\t\026\022 )Tj -0.022 Tw T* (PRISMA \033\032\022)Tj /Span<>> BDC ( )Tj EMC [(\033\031\026\031\212\022 \033\031\022\024\n\031\021\031\235 )0.5(\024\022\024\023\027\026\013 PUBMED \021)]TJ /Span<>> BDC ( )Tj EMC [(\204\f\027\n\023\032\031\025\025\031\235 )0.5(\240\020\016\027 Medline \240\027\016 \031\b\032\020\025\022\007\027\025\ \022\t \030\020\023\013 \033\r\240\f\022\n\020)]TJ 0 Tw (-)Tj 0.03 Tw T* (\006\022\022 \024\032\027\030\022 \020\025\b\f\031\t\016\013\007\025\031\ \235 \f\022\023\027\032\020\023\r\032\013. \211)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\023\027\026\020\023\022\007\027\024\n\022\235 \031\240\016\031\ \032 \021\n\f\005\007\027\025\013 \021\024\027 \022\024\024\f\027\030\031\ \021\020\025\022\t, \033\031\024\021\t\212\027\025\025\013\027 )Tj 0.059 Tw T* (\020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\031\235 \033\032\ \031\203\022\f\020\n\023\022\n\027 \033\031\024\023\n\031\020\b\r\f\t\006\ \022\031\025\025\031\b\031 \024\022\025\030\032\031\026\020 \033\031\024\ \f\027 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\b\031 \r\030\ \020\f\027\025\022\t \204\033\022)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\023\027\f\022\020\f\017\025\013\200 \025\031\021\031\031\240\032\020\016\ \031\021\020\025\022\235 \023\031\f\024\023\031\235 \n\022\213\n\022.)Tj 0.147 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \021)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\022\016 \021\n\f\005\007\027\025\013 5 \022\024\024\f\027\ \030\031\021\020\025\022\235)Tj /Span<>> BDC ( )Tj EMC (\227 1055 \033\020\006\022\027\025\023\031\021, 546)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \020\025\023\022\240\022\031\023\022\n\031\033\032\031\ )Tj 0 Tw (-)Tj 0.147 Tw T* (\203\022\f\020\n\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (509)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \240\027\016 \025\027\027. \004\031\024\023\n\031\020\ \b\r\f\t\006\022\031\025\025\013\235 \024\022\025\030\032\031\026 \016\025\ \020\007\022\026\031 \007\020\212\027 \032\020\016\021\022\021\020\f\024\ \t \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 )Tj -0.025 Tw T* (\033\020\006\022\027\025\023\031\021 \240\027\016 \020\025\023\022\240\020\ \n\023\027\032\022\020\f\017\025\031\235 \033\032\031\203\022\f\020\n\023\ \022\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\027\025\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\031\235 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \030\020\025\025\031\ \b\031 \026\027\023\031\030\020 )Tj 0.023 Tw T* (\033\032\031\203\022\f\020\n\023\022\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 16,1% \033\032\031\023\022\021 5,9% \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,30; 95% \220\002: 0,09\2310,96; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\).)Tj 0.215 Tw T* (\207\003\202\035\224\232\036\001\002\036: \020\025\023\022\240\022\031\023\ \022\n\031\033\032\031\203\022\f\020\n\023\022\n\020 \024\025\022\255\020\ \027\023 \007\020\024\023\031\023\r \032\020\016\021\022\023\022\t \033\031\ \024\023\n\031\020\b\r\f\t\006\022\031\025\025\031\b\031 \024\022\025\030\ \032\031\026\020 )Tj 0.023 Tw T* (\033\031\024\f\027 \204\025\030\031\024\n\031\033\022\007\027\024\n\031\b\ \031 \r\030\020\f\027\025\022\t \204\033\022\023\027\f\022\020\f\017\025\ \013\200 \025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\ \031\f\024\023\031\235 \n\022\213\n\022.)Tj /T1_2 1 Tf 0.01 Tc 0.225 Tw 8 0 0 8 42.5596 422.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.23 Tw 8.7 0 Td ( \033\031\024\023\n\031\020\b\r\f\t\006\022\031\025\025\013\235 \024\022\ \025\030\032\031\026, \020\025\023\022\240\020\n\023\027\032\022\020\f\017\ \025\020\t \033\032\031\203\022\f\020\n\023\022\n\020, \204\025\030\031\024\ \n\031\033\022\007\027\024\n\031\027 \r\030\020\f\027\025\022\027 \204\033\ \022\023\027\f\022\020\f\017\025\013\200 )Tj 0.023 Tw -8.705 -1.2 Td (\025\031\021\031\031\240\032\020\016\031\021\020\025\022\235 \023\031\f\024\ \023\031\235 \n\022\213\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.021 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.8( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.011 Tc -0.035 Tw 8.94 0 Td ( \215\024\020\024\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\203.\222., \207\026\035\022\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \214\017\022\031\021\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\202., \203\026\026\030\024\r \230.\200. \202\027\021\017\002\026\022\ \021\036\030\017\026\035\034\027\026\016 \023\030\024\235\017\035\026\022\ \021\017\022\026 \023\024\f\021\022\024\026\020\031\035\016\006\017\024\027\ \027\024\020\024)11( )]TJ 0.02 Tc -8.945 -1.2 Td (\f\017\027\007\030\024\n\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036\f\022\024\n \031\007\026\035\036\ \027\017\017 \027\024\r\024\024\002\030\026\024\r\026\027\017\005 \021\024\ \035\f\021\024\005 \022\017\001\022\017 \(\035\017\021\036\030\026\021\031\ \030\027\t\005 \024\002\024\030 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\). )Tj /T1_1 1 Tf -0.02 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td (2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC (149\226155. https://doi.org/10.33878/2073-7556-2026-25-1-149-155)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 114.0002 326.0332 Tm [(Antibacterial pr)31(e)11(v)12(ention of\022)-23.3(postcoagulation )]TJ -0.592 -1.111 Td [(s)10(yndr)20(ome during endoscopic r)31(emov)10(al of\022)-23.3(colon )]TJ 1.6 -1.111 Td [(neoplasms \(r)31(e)11(vie)11(w and meta-analy)10.1(sis\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 261.5293 Tm [(Nik)11(olay\022)-23.2(S.\022)-23.3(P)10(ogosov)]TJ 8.162 0 0 8.162 152.3006 266.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 156.9366 261.5293 Tm [(, Ar)-20(tem\022)-23.2(A)-31(.\022)-23.3(Balkar)20.1(ov)]TJ 0 Tw 8.162 0 0 8.162 268.9607 266.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 273.5966 261.5293 Tm [(, Ale)21(x)10(ey\022)-23.2(A)-31(.\022)-23.3(Lik)11(utov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 379.5451 266.1913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 390.8658 261.5293 Tm [(, Ily)21(a V)61.9(. Na)20(z)15(ar)20(ov)]TJ 0 Tw 8.162 0 0 8.162 487.393 266.1913 Tm (1)Tj 5.83 0 0 5.83 42.5197 247.19 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 243.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 235.19 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 231.86 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj /T1_1 1 Tf 0.143 Tw 9 0 0 9 90.7087 201.3561 Tm [(A\237IM: to assess ef)-40(f)-43(icacy of antibacter)-37(ial p)46(rev)13(ention for postcoagulation syndrome af)-46(ter endoscopic remov)16(al of )]TJ 0.023 Tw T* [(colon neoplas)33(ms.)]TJ -0.014 Tc -0.033 Tw T* [(MA)45(TERIAL)-28(S )0.5(A)53(ND METHODS: )0.5(literature )0.5(search )0.5(and )0.5(meta-analysis )0.5(w)12(ere per)-34(for)-14(med )0.5(in )0.5(accord)26(ance )0.5(with )0.5(the P)66(RISMA )0.5(guidelines)-14( )]TJ 0.016 Tw T* [(using the PUBMED search system in the Medline electronic d)26(atabase. The systematic revie)10(w included all studies dev)13(o)12.9(ted)-14( )]TJ 0.023 Tw T* [(to antibacter)-37(ial p)46(roph)12(ylactic of postcoagulation syndrome af)-46(ter endoscopic submucosal resection neoplas)32.9(ms of colon.)]TJ 0 Tc 0.065 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the analysis )0.5(included 5 studies)]TJ /Span<>> BDC ( )Tj EMC [(\227 1055 patients, 546 in the antibio)13(tic p)46.1(rev)12.9(ention g)14(roup and 509 in the )]TJ 0.099 Tw 0 -1.111 TD [(g)14(roup without it. P)15(ostcoagulation syndrome w)13(as low)12(er in antibacter)-36.9(ial p)46(roph)12(ylaxis g)13.9(roup 5,9% vs 16,1% without )]TJ 0.023 Tw T* [(antibacter)-36.9(ial p)46(rev)13(ention g)14(roup \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.30; 95% CI: 0,09\2310,96; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.04\).)Tj 0.071 Tw T* [(C)21(ON)22(CLUSION: )0.6(antibio)13.1(tic )0.5(p)46(roph)12(ylactic )0.6(reduces )0.6(the )0.6(incidence )0.6(of )0.5(postcoagulation )0.6(syndrome )0.6(af)-46(ter )0.5(endoscopic )0.5(remov)16(al )]TJ 0.023 Tw T* [(of epithelial neoplas)33.1(ms of the colon.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 96.0869 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( postcoagulation syndrome, antibacter)-36.9(ial p)46(roph)12(ylactic, endoscopic remov)16(al of)]TJ /Span<>> BDC ( )Tj EMC [(epithelial neoplas)33(ms of)]TJ /Span<>> BDC ( )Tj EMC (the colon)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 556.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 547.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 209.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 200.9331 Tm (ABSTRACT)Tj ET q 0 0 566.929 793.701 re W n BT 1 0.68 0 0.12 k /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5895 837.3533 Tm [(\213\207)-21(\r)41(\037\037\t\037)-19.9(\b\006\215)]TJ /T1_0 1 Tf 0 -1.605 TD [(MET)30(A)5(\243)5(ANAL)30(Y)30(SIS)]TJ ET Q BT 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\235\240\032)50(\f\f\007\f)-21(\035\030\203)]TJ 53.418 0 Td [(MET)30(A)-41(-)-41.9(ANAL)30(Y)30(SIS)]TJ /T1_5 1 Tf 25 0 0 25 505.5896 56.0378 Tm (149)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 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P)35(r)-37(inc)-24(iples of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical )]TJ 0.072 Tw -1.296 -1.25 Td [(car)-24(e for r)-24(ec)-15.9(t)15(al w)-14(ounds. )]TJ /T1_1 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC [(the N)18(ational Medical and Surgical )]TJ 0.023 Tw T* [(Center named af)-46(ter N.I.)]TJ /Span<>> BDC ( )Tj EMC (Pirogov.)Tj /T1_0 1 Tf ( 2024;19\(2\):52\22657. \(In Russ.\).)Tj -0.006 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)50(r)-33(ansi)-24(t)-31.9(ions)]TJ /Span<>> BDC ( )Tj EMC (S.N., Onnintsev)Tj /Span<>> BDC ( )Tj EMC [(I.E., K)25(ozl)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(N.S., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Ana)15(t)17(omical )]TJ 0.06 Tw -1.796 -1.25 Td [(and sur)-32(gical stud)17(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ef)-55.9(f)-28(ic)-24(iency and safe)-12(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(per)-37(ineal dr)-32.9(aina)-17(ge )]TJ -0.029 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(pel)30(v)-16(ic cell)35(ul)-16(ar sp)32(a)-17(ces in r)-24(ec)-16(t)15(al w)-14(ounds. )]TJ /T1_1 1 Tf 0 Tw [(P)15(olytrauma)]TJ /T1_0 1 Tf -0.029 Tw (. 2025;2:77\22688. )Tj 0.023 Tw T* [(\(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1819-1495-2025-2-88-88)Tj /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ 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of\022th)11(e )]TJ -0.724 -1 Td [(e)21(xtr)21(aperitoneal par)-19.9(t of\022th)11(e r)31(ectum complicated b)10(y F)15(ournier\236)63(s gangr)31(ene)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.185 Tw 10 0 0 10 42.5197 724.8299 Tm [(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016 )0.5(\026\021\030\031\007\027\036\027\026 )0.6(\024\f\024\002\036\027\027\024\f\021\016\n\017 )]TJ 0 Tw 0 -1.218 TD (\024\002\036\f\023\036\004\036\027\017\016 \023\030\036\036\n\f\021\r\036\ \027\027\024\f\021\017 \n\036\032\007\031 \220\021\026\023\026\n\017.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\031\002\212\002\f\b\t\003\r\f\001\b\004\235 \t\b\226\002\006\214\004\204\ \t\235)Tj 0.295 Tw 0 -1.218 TD (\255\017\027\035\032\255\034\036 \200\032\037\034\036\025\020\032:)Tj /T1_1 1 Tf ( \215\026\006\017\036\027\021 \007\024\002\030\024\r\024\035\034\027\024\ \023\024\007)Tj 0 Tw (-)Tj 0.34 Tw T* (\023\017\f\026\035 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\036\ \f\024\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\031\002\035\017\022\026\006\017\033 )Tj 0.214 Tw 0 -1.218 TD (\023\036\030\f\024\027\026\035\034\027\024\005 \n\036\007\017\006\017\027\ \f\022\024\005 \017\027\235\024\030\n\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\035\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\036\027\027\024\005 \235\024\030\n\036.)Tj /T1_2 1 Tf T* (\224\035\032\027\017\031\032\022\025\017\255\020\205: )Tj /T1_1 1 Tf 0.903 Tw 8.709 0 Td (\025\024\035\035\036\022\021\017\r \026\r\021\024\030\024\r \r\t\030\026\ \032\026)Tj 0 Tw (-)Tj 0.402 Tw -8.709 -1.218 Td (\036\021 \002\035\026\020\024\007\026\030\027\024\f\021\034 \215\026\027\ \024\r\031 \200\016\004\036\f\035\026\r\031 \200\026\f\017\035\034\036\r\ \017\004\031, )Tj 0.007 Tw T* [(\222\024\020\024\n\024\027\016\027\031 \025\026\023\030\036\035\031 \216\ \026\004\026\021\031\030\024\r\017\004\031, )0.5(\214\031\002\036\027\006\031 \200\026\f\017\035\017\033 )]TJ 0.543 Tw T* [(\202\035\036\022\f\026\027\007\030\024\r\017\004\031, )0.6(\217\016\007\027\024\r\031 )0.5(\202\027\007\030\017\026\027\031 )0.5(\202\035\036\022\f\036\036\r\017\004\031, )]TJ -0.011 Tw 0 -1.218 TD [(\215\017\013\026\035\034\027\017\022\024\r\024\005 )0.5(\224\035\017\017 \210\035\036\020\024\r\027\036, \212\017\007\026\b\026\ \027\024\r\031 \202\030\f\036\027\031 )]TJ -0.08 Tw 0 -1.218 TD [(\025\026\002\036\022\024\r\017\004\031, \207\017\007\032\017\036\r\024\005\ )0.5(\202\035\017\027\036 \230\f\n\026\017\035\024\r\027\036, \025\024\030\032\ \031\022\031 )]TJ 0 Tw 0 -1.218 TD (\204\017\b\026\017\035\031 \222\036\030\020\036\036\r\017\004\031)Tj /T1_2 1 Tf T* [(GRA)28(T)-23(ITUDE: )]TJ /T1_1 1 Tf 0.144 Tw 5.35 0 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC (team of)Tj /Span<>> BDC ( )Tj EMC [(aut)-13(hor)-10(s e)-18(xp)25(r)-24(esses i)-24(ts gr)-33(a)15(t)-32(i)]TJ 0 Tw (-)Tj 0.191 Tw -5.35 -1.218 Td [(tude t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(V)-16(y)22(a)-17(chesl)-16(av V. P)40(anov, K)-15.9(ap)25(r)-24(el)]TJ /Span<>> BDC ( )Tj EMC (K.)Tj /Span<>> BDC ( )Tj EMC [(S)-16(o)-16(gomony)22(an, )]TJ 1.373 Tw T* [(V)25(asil)35(y)]TJ /Span<>> BDC ( )Tj EMC (A.)Tj /Span<>> BDC ( )Tj EMC [(L)35(ubents, Andr)-36.9(ian A. R)-19.9(y)22(adnov, )]TJ 0.705 Tw T* [(Y)35(ul)-31(ia)]TJ /Span<>> BDC ( )Tj EMC (O.)Tj /Span<>> BDC ( )Tj EMC [(P)-24(ishchalnikov)-14.9(a, Ar)-10(sen K. Dzid)42(akhanov, )]TJ 0 Tw T* [(Al)-31(ina)]TJ /Span<>> BDC ( )Tj EMC (I.)Tj /Span<>> BDC ( )Tj EMC [(Bid)17.1(zhiev)-14.9(a, Mikhail S.)]TJ /Span<>> BDC ( )Tj EMC [(K)25.1(or)-24(zhuk)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.522 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-5.9(\017)-5.5(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \205)27.6(\r)-4.3(\032\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.024 Tc 0.024 Tw T* [(\036\024)-14.2(\027)-44.6(\f)-20.7(\027)-17.4(\021)-18.5(\022)-4.6(\007)]TJ /Span<>> BDC 3.617 0 Td ( )Tj EMC [(\206)69.9(.)4.5(\211.)]TJ /T1_1 1 Tf 0 Tc 0.742 Tw -3.617 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.029 Tc 0.771 Tw [( \205)-21.2(\020)-27.3(\026)-25(\031)-26.2(\200)-21.6(\022)-21.8(\025)]TJ /Span<>> BDC 19.281 0 Td ( )Tj EMC [(\217)-1.4(.\002.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -19.281 -1.218 Td [(\003)-27.3(\f\022)-5.3(\026)-6(\031\021)]TJ /Span<>> BDC 3.021 0 Td ( )Tj EMC [(\004)19.3(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0 Tc 0.977 Tw -3.021 -1.218 Td [(\210)-9.4(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\026\027)-0.6(\026)-33.1(\035)2.2(\017)2.7( \007)-20.1(\026\027)1.7(\027)1.7(\t)-12.8(\b)-9.3(:)]TJ /T1_3 1 Tf -0.028 Tc 1.005 Tw [( \221)-23(\020)-33.2(\f)-18.2(\005)-23.5(\032)-25(\020)]TJ /Span<>> BDC 19.116 0 Td ( )Tj EMC [(\217.)0.5(\211)-3.7(.)-20.2(,)-28( )]TJ -0.029 Tc 0.029 Tw -19.116 -1.218 Td [(\206)-39.5(\r)-21.9(\026)-20.2(\t)-18.8(\025)-18.9(\006)-26.3(\027)-22.4(\021)]TJ /Span<>> BDC 3.867 0 Td ( )Tj EMC [(\211)-4.7(.\001.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -3.867 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf -0.024 Tc 0.024 Tw 7.694 0 Td [( \036\024)-14.2(\027)-44.6(\f)-20.7(\027)-17.3(\021)-18.5(\022)-4.7(\007)]TJ /Span<>> BDC 3.85 0 Td ( )Tj EMC [(\206)69.9(.)4.5(\211.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.543 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf [( \205)27.6(\r)-4.3(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.5(.)7.3(\003)-2.3(.)]TJ /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.276 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 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/T1_1 1 Tf -0.002 Tc 0.715 Tw T* [(D)-3.6(a)-10.4(t)-29.7(a)-2( p)-5.8(r)-8(o)-9(c)-1.8(e)-15.3(s)-14.8(s)-18.6(i)5.1(n)-3.8(g)-2( an)-6.6(d)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_3 1 Tf 0 Tc 0.713 Tw 14.072 0 Td [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(al)4.3(u)6.1(r)7.7(a)-14(, )]TJ -0.005 Tc 0.005 Tw -14.072 -1.218 Td [(V)20.9(a)-5.1(le)-6.7(r)-40.3(i)-5.1(y)]TJ /Span<>> BDC 2.664 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(R)5.2(umy)-1.2(a)-5.8(n)-1.2(t)-34.1(se)-9(v)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.752 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.2(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_3 1 Tf [( R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(E)-3.6(s)4.9(e)-1.9(l)4.8(e)-4(v)-28.6(i)2.6(c)1.8(h)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf -0.006 Tc 0.006 Tw 3.238 0 Td [( D)-8(mi)-5(t)-11.4(r)-41.3(i)-2.6(i)]TJ /Span<>> BDC 2.951 0 Td ( )Tj EMC [(A)-18.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(S)9.8(ur)-3.6(o)-6.6(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw 15.976 47.494 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.124 Tw T* (\213\f\036\035\036\r\017\004 \217\024\n\026\027 \200\035\026\007\017\n\017\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \027\026\004\026\035\034\027\017\022 )Tj 0.238 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 \022\035\017\027\017\022\017 \022\026\235\036\007\030\t\ \r\024\036\027)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\ \036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\ \036\n\017\017 )Tj 0.003 Tw T* (\017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, \232\210\211\200\210 \253\222\026\ \027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005 )Tj 0.326 Tw T* [(\n\036\007\017\022\024-\f\024\006\017\026\035\034\027\t\005 )0.6(\017\027\f\021\017\021\031\021\273, )0.6(\020.)]TJ /Span<>> BDC ( )Tj EMC 14.925 0 Td (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; )Tj 0 Tw -14.925 -1.218 Td (ORCID 0000-0003-3249-233X; SPIN-\022\024\007: 1037\2268736)Tj 0.086 Tw T* (\222\026\n\024\b\017\027 \210\035\036\020 \230\020\024\030\036\r\017\004\ )Tj /Span<>> BDC ( )Tj EMC (\227 \027\026\004\026\035\034\027\017\022 \024\021\007\036\035\036\027\017\ \016 \027\036)Tj 0 Tw (-)Tj 0.042 Tw T* (\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\017\017 \205\206\ \025\211 \2531602 \200\025\206\273 \204\210 \217\205, \217\024\f\021\024\ \r-)Tj 0.618 Tw T* (\027\026-\212\024\027\031; ORCID 0009-0004-9011-872X; SPIN-\022\024\007:\ )Tj 0 Tw T* (2945\2269017)Tj 0.222 Tw T* (\202\035\017\n\024\r \215\026\r\036\035 \202\035\017\n\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\031\001\026\021\036\035\034 \024\030\007\017\027\026\021\031\ \030\t )Tj 0.15 Tw 0 -1.218 TD (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.042 Tw 0 -1.218 TD (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0009-00\ 07-3105-764X; )Tj 0 Tw 0 -1.218 TD (SPIN-\022\024\007: 5928\2263805)Tj 0.327 Tw T* (\207\026\035\033\030\026 \210\035\036\020 \200\026\035\036\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030\001\017\005 \023\030\036)Tj 0 Tw (-)Tj 0.821 Tw T* (\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\ \036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017\ )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.337 Tw T* [(\217\205, )0.5(\232\210\211\200\210 )0.6(\253\222\026\027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005\ )0.5(\n\036\007\017\022\024-\f\024\006\017\026\035\034)]TJ 0 Tw (-)Tj 0.006 Tw T* (\027\t\005 \017\027\f\021\017\021\031\021\273, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-)Tj 0 Tw T* (7826-8056; SPIN-\022\024\007: 9260\2269850)Tj 0.229 Tw T* (\217\031\n\016\027\006\036\r \200\026\035\036\030\017\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \023\030\036\023\024\007\026)Tj 0 Tw (-)Tj 0.2 Tw T* (\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\036\027\027\024\ -\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\036\027\ \027\024-)Tj 0.429 Tw T* (\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\036\n\017\017 \ \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, )Tj 0.571 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-7526-6282; )Tj 0 Tw T* (SPIN-\022\024\007: 8166\2269820)Tj 0.311 Tw T* [(\222\031\030\024\r )0.5(\212\n\017\021\030\017\005 )0.6(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 13.948 0 Td [(\227 )0.5(\007.\n.\027., )0.6(\023\030\024\235\036\f)]TJ 0 Tw (-)Tj 0.238 Tw -13.948 -1.218 Td (\f\024\030, \027\026\004\026\035\034\027\017\022 \022\026\235\036\007\030\ \t \r\024\036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\ \017\017 )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.038 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 02-4519-0018; )Tj 0 Tw T* (SPIN-\022\024\007: 5346\2261613)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(R)11(oman V. Eselev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3249-233X)Tj T* (Oleg)Tj /Span<>> BDC ( )Tj EMC (I. Samokhin)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0004-9011-872X)Tj T* [(P)40(avel A. Al)-30.9(imov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3105-764X)Tj T* [(Oleg V. Bal)35.1(ur)-33(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7826-8056)Tj T* [(V)25(aler)-37(iy N. Rumy)22.1(antsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7526-6282)Tj T* [(Dmi)-24(tr)-36.9(i)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(A. Sur)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4519-0018)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 213.3539 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.303 Tw 8 0 0 8 42.5197 200.5192 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bo)-14(wen)]TJ /Span<>> BDC ( )Tj EMC [(D, Hughes T)47.1(h, Jul)-30.9(ieb\370-Jones)]TJ /Span<>> BDC ( )Tj EMC [(P, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)10(our)-15(nier\241s gan)]TJ 0 Tw (-)Tj 0.011 Tc 0.414 Tw -1.296 -1.25 Td [(gr)-24.1(ene: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24.2(ev)-16.1(iew of)]TJ /Span<>> BDC ( )Tj EMC [(p)24.8(r)-24.2(edic)-16.1(t)-32.2(i)-16.1(ve scor)-37.2(ing sy)-13.1(stems and p)24.8(r)-33.1(a)-17.2(c)-16.1(t)-32.2(ical)11( )]TJ 0.004 Tc 0.35 Tw 0 -1.25 TD [(guide )0.5(for )0.5(p)31.9(a)15(t)-32(ient )0.5(mana)-17(gement. )]TJ /T1_3 1 Tf 14.269 0 Td [(Ther )0.5(Adv )0.5(Infect )0.5(Dis.)]TJ /T1_1 1 Tf [( )0.5(2024 )0.5(Mar)4( )]TJ 0 Tc 0.023 Tw -14.269 -1.25 Td [(19;11:20499361241238521. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1177/20499361241238521)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.381 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td [(L)34.8(ewis)]TJ /Span<>> BDC ( )Tj EMC (GD, Majeed)Tj /Span<>> BDC ( )Tj EMC [(M, Ol)-16.2(ang)]TJ /Span<>> BDC ( )Tj EMC [(C)19.8(A, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)9.8(our)-15.2(nier\241s Gangr)-24.1(ene)10( )]TJ 0 Tc 0.217 Tw -1.327 -1.25 Td [(Dia)-17(gnosis )0.5(and )0.5(T)50(r)-24(ea)15(tment: )0.6(A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-12.9(stema)15(t)-32(ic )0.5(R)13(ev)-16(iew. )]TJ /T1_3 1 Tf 0 Tw 20.507 0 Td (Cureus)Tj /T1_1 1 Tf 0.217 Tw [(. )0.5(2021 )0.5(O)-16(c)-16(t )]TJ 0.023 Tw -20.507 -1.25 Td [(21;13\(10\):e18948. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.18948)]TJ 0 0 0 1 k /GS1 gs 0.197 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\206\030\017\027\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \206\030\017\027\036\r)Tj /Span<>> BDC ( )Tj EMC (\025.\204. \203\036\022\030\024\021\017\017\030\031\033\013\017\005 \235\ \026\f\006\017\017\021. \222\026\027\022\021-)Tj 0.023 Tw -1.296 -1.25 Td (\215\036\021\036\030\002\031\030\020, 2008. \230\007\026\021\036\035\034\ \f\021\r\024: \206\017\023\023\024\022\030\026\021. 120 \f.)Tj 0.245 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\026\f\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217., \222\026\n\024\b\r\026\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \003\026\r\030\026\032\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \222\024\007\036\030\032\026\027\017\036 )Tj 0.003 Tw -1.296 -1.25 Td (\027\036\024\021\035\024\032\027\024\005 \f\023\036\006\017\026\035\017\ \017\030\024\r\026\027\027\024\005 \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036)Tj 0 Tw (-)Tj 0.008 Tc 0.349 Tw T* (\n\036\027\027\024\n \r\024\036\027\027\024\n \022\024\027\235\035\017\022\ \021\036. )Tj /T1_3 1 Tf (\215\027\030\022\006\022\025\020: \023\027\031\032\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\020\n\023\022\n\020.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2023;4:7\22617. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.56871/MTP.2023.98.31.042)Tj 0 0 0 1 k /GS1 gs 0.017 Tc 0.604 Tw 29.055 15 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.346 0 Td (\213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 0 Tc 0.104 Tw -1.346 -1.25 Td (4D-\025\024\027\006\036\023\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \r\027\036\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\005\ )Tj 0.111 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \200\f\036 \035\017 \021\026\ \022 \024\007\027\024\027\026\004\027\024? )Tj /T1_3 1 Tf 0 Tw (\004\031\f\022\023\032\020\021\026\020)Tj /T1_1 1 Tf 0.111 Tw (. 2025;1:59\226)Tj -0.018 Tw T* [(66. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1819-1495-2025-1-59-66)Tj 0 0 0 1 k /GS1 gs -0.018 Tw [( \217\036\032\017\n \007\024\f\021\031\023\026: ht)-30(tp://)]TJ 0 Tw T* [(pol)35(y-tr)-32.9(auma.r)-22(u/inde)-17.9(x.php/pt/ar)-22(t)-32(icle/v)-15.9(iew/587.)]TJ 0.105 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(avenson)]TJ /Span<>> BDC ( )Tj EMC (GS, Cohen)Tj /Span<>> BDC ( )Tj EMC [(A. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15(al injur)-37(ies. )]TJ /T1_3 1 Tf 0 Tw [(Amer)-37(ican )]TJ 0.011 Tc 0.389 Tw -1.296 -1.25 Td [(J)0.5(o)0.6(u)0.5(r)-13.4(n)0.5(a)0.5(l)0.6( o)0.5(f)]TJ /Span<>> BDC 4.503 0 Td ( )Tj EMC [(S)0.6(u)0.5(r)0.5(g)12.6(e)0.5(r)-42.5(y)]TJ /T1_1 1 Tf 3.671 0 Td [(.)0.5( 1)0.5(9)0.5(7)0.6(1)0.5(;)0.5(1)0.5(2)0.6(2)0.5(\()0.5(2)0.6(\))0.5(:)0.5(2)0.6(2)0.5(6)0.5(\226)0.5(2)0.6(3)0.5(0)0.5(.)0.6( d)-15.5(o)0.5(i)0.6(:)]TJ /Span<>> BDC 12.615 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw [(1)0.5(0)0.6(.)0.5(1)0.6(0)0.5(1)0.5(6)0.5(/)0.6(0)0.5(0)0.5(0)0.5(2)0.6(-)]TJ 0 Tc 0 Tw -20.788 -1.25 Td (9610\(71\)90322-9)Tj 0 0 0 1 k /GS1 gs 0.107 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\036\f\017\022\017\027)Tj /Span<>> BDC ( )Tj EMC 3.852 0 Td [(\230.\203., )0.5(\215\036\030\036\b\024\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.143 0 Td [(\222.\203., )0.5(\210\027\027\017\006\036\r)]TJ /Span<>> BDC ( )Tj EMC 6.079 0 Td [(\230.\213., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.083 0 Td [(\f\024\026\r\021. )0.5(\233\021\026\023\027\024\036 )]TJ 0.19 Tw -21.453 -1.25 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\036 )0.5(\035\036\004\036\027\017\036 \030\026\027\036\027\017\005 \r\027\036\002\ \030\033\001\017\027\027\024\020\024 \024\021\007\036\035\026 \023\030\016\ \n\024\005 )]TJ 0 Tw T* (\022\017\001\022\017. )Tj /T1_3 1 Tf 3.197 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_1 1 Tf 0.04 Tw [(. 2024;23\(3\):41\22649. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.197 -1.25 Td (7556-2024-23-3-41-49)Tj 0 0 0 1 k /GS1 gs 0.012 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\017\n)Tj /Span<>> BDC ( )Tj EMC (\230.\224., \215\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \204\031\f\026\017\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \215\030\017\027\006\017\023\t \024\022\026\026)Tj 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.6396 56.0378 Tm (147)Tj ET endstream endobj 640 0 obj <>/Border[0 0 0]/H/N/Rect[150.572 177.815 248.484 168.519]/Subtype/Link/Type/Annot>> endobj 641 0 obj <>/Border[0 0 0]/H/N/Rect[120.228 147.815 193.851 138.519]/Subtype/Link/Type/Annot>> endobj 642 0 obj <>/Border[0 0 0]/H/N/Rect[103.02 87.8152 203.515 78.5192]/Subtype/Link/Type/Annot>> endobj 643 0 obj <>/Border[0 0 0]/H/N/Rect[301.49 177.815 417.482 168.519]/Subtype/Link/Type/Annot>> endobj 644 0 obj <>/Border[0 0 0]/H/N/Rect[446.33 147.815 496.063 138.359]/Subtype/Link/Type/Annot>> endobj 645 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 137.815 331.696 128.519]/Subtype/Link/Type/Annot>> endobj 646 0 obj <>/Border[0 0 0]/H/N/Rect[443.335 107.815 496.063 98.3592]/Subtype/Link/Type/Annot>> endobj 647 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 97.8152 349.04 88.5192]/Subtype/Link/Type/Annot>> endobj 655 0 obj <> endobj 654 0 obj <> endobj 653 0 obj <> endobj 652 0 obj <> endobj 651 0 obj <> endobj 650 0 obj <> endobj 649 0 obj <> endobj 648 0 obj <> endobj 610 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.06 Tw 10 0 0 10 70.8661 724.8299 Tm [(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\031\033 )0.6(\(\006\036\235\021\030\017\026\022\f\024\027 )0.5(2 \020)]TJ /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC 16.79 0 Td [(2 \030\026\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\f\031\021)Tj 0 Tw (-)Tj 0.029 Tw -16.79 -1.218 Td (\022\017, \n\036\021\030\024\027\017\007\026\024\035 100 \n\035)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (3 \030\026\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017\), \007\036\017\027\021\024\022)Tj 0 Tw (-)Tj 0.649 Tw 0 -1.218 TD (\f\017\022\026\006\017\024\027\027\031\033, \023\030\024\021\017\r\024\r\ \024\f\023\026\035\017\021\036\035\034\027\031\033, \f\017\n\023\021\024\ \n\026)Tj 0 Tw (-)Tj 0.337 Tw T* [(\021\017\004\036\f\022\031\033. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\255\036\022\021\017\r\027\t\n )0.5(\023\030\017\004\017\027\026\n \r\t\023\024\035\027\036\027\017\036 )]TJ 0.266 Tw T* (\002\026\022\021\036\030\017\024\035\024\020\017\004\036\f\022\024\020\024\ \017\f\f\035\036\007\024\r\026\027\017\016 \030\026\027\036\r\024\020\024\ \024\021\007\036)Tj 0 Tw (-)Tj 0.088 Tw T* (\035\016\036\n\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036\023\036\030\036\004\017\f\035\036\027\027\t\b \220\021\026\023\ \026\b \027\036 )Tj 0.14 Tw 0 -1.218 TD (\r\t\023\024\035\027\016\035\024\f\034. \203\026)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\036 \f\031\021\022\017 \023\026\006\017\036\ \027\021 \023\036\030\036\r\036)Tj 0 Tw (-)Tj -0.027 Tw 0 -1.218 TD (\007\036\027 \026\r\017\026\006\017\024\027\027\t\n \021\030\026\027\f\023\ \024\030\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\036 \n\036\007\017\006\017\027\f\022\024\036 )Tj -0.039 Tw T* (\031\004\030\036\032\007\036\027\017\036 4 \211\204\215 \007\035\016 \023\ \030\024\007\024\035\032\036\027\017\016 \035\036\004\036\027\017\016. \200\ )Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\036\005\001\036\n \023\024\035\031\004\026\035 \022\024\027\f\036\030\ \r\026\021\017\r\027\024\036 \035\036\004\036\027\017\036: \023\030\024\007\ \024\035\032\036)Tj 0 Tw (-)Tj 0.171 Tw T* [(\027\026 )0.5(\026\027\021\017\002\017\024\021\017\022\024\021\036\030\026\023\017\016\ )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 11.743 0 Td [(\f\b\036\n\036 )0.5(\023\030\036\007\t\007\031\013\036\020\024 )0.6(\220\021\026)]TJ 0 Tw (-)Tj 0.103 Tw -11.743 -1.218 Td (\023\026, \023\036\030\036\r\016\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\016\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\024\030\026\f\021\r\024\030\017\n\024\005 \024\f\027\024\r\036\ )Tj 0.025 Tw 0 -1.218 TD (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\). \025)Tj /Span<>> BDC ( )Tj EMC (14-\n \f\031\021\022\026\n \023\024\f\035\036 \024\023\036\030\026\006\017\ \017 \016\r\035\036\027\017\016 \r\024\f)Tj 0 Tw (-)Tj 0.216 Tw 0 -1.218 TD (\023\026\035\036\027\017\016 \030\036\020\030\036\f\f\017\030\024\r\026\035\ \017, \035\026\002\024\030\026\021\024\030\027\t\036 \023\024\022\026\026\ \021\036\035\017 )Tj 0.074 Tw 0 -1.218 TD (\027\024\030\n\026\035\017\024\r\026\035\017\f\034, \030\026\027\t \n\024\ \001\024\027\022\017 \026\032\017\035\017 \r\021\024\030\017\004\027\t\n\ )Tj 0 Tw T* (\027\026\021\016\032\036\027\017\036\n \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.267 Tw T* [(\215\030\017 \r\t\023\024\035\027\036\027\017\017 \030\036\022\021\024\030\ \024\n\026\027\024\f\022\024\023\017\017 )0.5(\024\021\n\036\004\036\027\024 \026)]TJ 0 Tw (-)Tj 0.246 Tw T* (\032\017\r\035\036\027\017\036 \030\026\027\t \023\030\016\n\024\005 \022\ \017\001\022\017 \r\021\024\030\017\004\027\t\n \027\026\021\016\032\036\ )Tj 0 Tw (-)Tj 0.297 Tw T* [(\027\017\036\n. )0.5(\215\026\006\017\036\027\021 )0.6(\r\t\023\017\f\026\027 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 12.423 0 Td [(\026\n\002\031\035\026\021\024\030\027\024\036 )0.5(\035\036\004\036\027\017\036 )]TJ 0.233 Tw -12.423 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\n\036\027\007\026\006\017\036\005 \023\035\026\027\024\r\ \024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\ \036\027\017\016 )Tj 0.267 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \r\024\f\f\021\026\027\024\r\035\036\027\017\016 \ \027\036\023\030\036\030\t\r\027\024\f\021\017 \021\024\035\f\021\024\005\ )Tj 0 Tw T* (\022\017\001\022\017 \004\036\030\036 3 \n\036\f\016\006\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 432.5578 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.013 Tw 10 0 0 10 70.8661 408.2018 Tm (\210\f\027\024\r\027\t\n \023\024\007\b\024\007\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \200\002\217\215\025 )Tj 0.234 Tw T* (\016\r\035\016\036\021\f\016 \023\030\017\n\036\027\036\027\017\036 4D-\022\ \024\027\006\036\023\006\017\017. \210\007\027\026\022\024 \f\031\013\036\ )Tj 0 Tw (-)Tj 0.201 Tw T* [(\f\021\r\031\036\021 )0.5(\030\026\027\024\030\024\007\027\024\f\021\034 )0.6(\023\024\007\b\024\007\024\r )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 14.855 0 Td [(\030\036\026\035\017\026\006\017\017 )0.6(\022\035\033)]TJ 0 Tw (-)Tj 0.146 Tw -14.855 -1.218 Td (\004\036\r\t\b \036\036 \220\035\036\n\036\027\021\024\r, \004\021\024 \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\t\b \022\035\017\027\017\004\036\f\022\017\ \b )Tj 0.028 Tw T* (\f\017\021\031\026\006\017\016\b \n\024\032\036\021 \024\022\026\026\021\ \034 \027\026\004\017\n\t\005 \022\035\017\027\017\004\036\f\022\017\005\ \220\235)Tj 0 Tw (-)Tj 0.241 Tw T* (\235\036\022\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 )Tj 0 Tw T* ([5,8,9].)Tj 0.173 Tw T* (\200 \023\030\036\007\f\021\026\r\035\036\027\027\024\n \022\035\017\027\ \017\004\036\f\022\024\n \f\035\031\004\026\036 \r\t\023\024\035\027\036\ \027\017\036 )Tj 0.069 Tw T* [(\024\f\027\024\r\027\024\020\024 )0.5(\220\035\036\n\036\027\021\026 )0.6(\025\024\027\006\036\023\006\017\017)]TJ /Span<>> BDC ( )Tj EMC 13.575 0 Td [(\227 )0.5(\024\021\r\036\007\036\027\017\036 )0.6(\023\026\f\f\026)]TJ 0 Tw (-)Tj 0.085 Tw -13.575 -1.218 Td (\032\026 \023\030\024\022\f\017\n\026\035\034\027\036\036 \030\026\027\036\ \027\017\016 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.07 Tw T* (\036\n\036 \026\020\035\031\001\036\027\017\016 \024\021\r\024\007\016\013\ \036\005 \004\026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017\ \002\036 )Tj 0.136 Tw T* (\r\024\n\024\032\027\024\f\021\017 \023\030\024\r\036\007\036\027\017\016\ \026\027\021\036\020\030\026\007\027\024\020\024 \007\017\f\021\026\035\ \034\027\024\020\024 )Tj 0.088 Tw T* (\024\021\n\t\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\024\005 \n\036\030\036 \023\024\r\035\ \017\016\035\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\026)Tj 0 Tw (-)Tj 0.257 Tw T* (\n\017\027\026\006\017\033 \022\035\036\021\004\026\021\024\004\027\t\b \ \023\030\024\f\021\030\026\027\f\021\r \021\026\026 \f\024\007\036\030\032\ \017)Tj 0 Tw (-)Tj 0.16 Tw T* (\n\t\n \023\030\016\n\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \021\026\022\024\020\024 \020\030\024\027\024\ \020\024 \024\f)Tj 0 Tw (-)Tj T* (\035\024\032\027\036\027\017\016, \022\026\022 \206\205.)Tj 0.17 Tw T* [(\203\036\024\002\b\024\007\017\n \023\036\030\f\024\027\026\035\017\017\ \030\024\r\026\027\027\t\005 )0.5(\023\024\007\b\024\007 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 )Tj 0.046 Tw T* (\220\035\036\n\036\027\021\024\r \025\024\027\006\036\023\006\017\017 \r\ )Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \031\030\024\r\027\016 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026)Tj 0 Tw (-)Tj 0.095 Tw T* (\030\026\022\021\036\030\026 \023\024\r\030\036\032\007\036\027\017\016 \ \022\017\001\022\017, \021\016\032\036\f\021\017 \f\024\f\021\024\016\027\ \017\016 \030\026)Tj 0 Tw (-)Tj -0.073 Tw T* (\027\036\027\024\020\024. \200)Tj /Span<>> BDC ( )Tj EMC (\024\023\017\f\026\027\027\024\005 \f\017\021\031\026\006\017\017 \002\024\ \035\036\036 \006\036\035\036\f\024\024\002\030\026\027\t\n )Tj 0.355 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021\f\016 \r\026\030\017\026\027\ \021 \023\036\030\r\017\004\027\024\005 \b\017\030\031\030\020\017\004\036\ \f\022\024\005 )Tj 0.105 Tw T* [(\021\026\022\021\017\022\017, )0.6(\030\036\026\035\017\024\r\026\027\027\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.181 0 Td [(\f\035\036\007\031\033\013\036\n )0.6(\024\002\255\036\n\036: )0.5(\035\026\023\026)]TJ 0 Tw (-)Tj 0.027 Tw -11.181 -1.218 Td [(\030\024\021\024\n\017\016, )0.5(\030\036\r\017\017\016 )0.6(\024\030\020\026\027\024\r )0.5(\002\030\033\001\027\024\005 )0.6(\023\024\035\024\f\021\017, )0.5(\235\024\030\n\017)]TJ 0 Tw (-)Tj 0.154 Tw T* (\030\024\r\026\027\017\036 \007\r\031\f\021\r\024\035\034\027\024\005 \f\ \017\020\n\024\f\021\024\n\t, \023\024\f\035\024\005\027\024\036 \031\001\ \017)Tj 0 Tw (-)Tj 0.114 Tw T* (\r\026\027\017\036 \035\026\023\026\030\024\021\024\n\027\024\005 \030\026\ \027\t, \r\t\023\024\035\027\036\027\017\036 \007\017\f\021\026\035\034\027\ \024\020\024 )Tj 0.005 Tw T* [(\024\021\n\t\r\026\027\017\016 )0.6(\024\021\022\035\033\004\036\027\027\024\020\024 )0.5(\031\004\026\f\021\022\026 )0.6(\022\017\001\022\017 )0.5(\004\036\030\036 )0.6(\f\021\024\n\031, )]TJ 0.09 Tw T* (\024\021\022\026 \024\021 \031\001\017\r\026\027\017\016 \030\026\027\036\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \036\020\024 \027\036\027\026\004\017\021\036\035\034)Tj 0 Tw (-)Tj 0.167 Tw T* (\027\024\020\024 \030\026\n\036\030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\022\026 \024\021 \030\031\021\017\027\027\024\020\024 \002\017\ \035\026\021\036\030\026\035\034\027\024\020\024 )Tj 0.108 Tw 23.244 64.543 Td (\023\026\030\026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\ \027\017\030\024\r\026\027\017\016 \027\036\017\n\036\027\036\027\027\t\ \b \022\035\036\021)Tj 0 Tw (-)Tj 0 -1.218 TD (\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\r \021\ \026\026.)Tj 0.349 Tw 0 -1.218 TD (\211\f\021\030\026\027\036\027\017\036 \027\036\007\036\f\021\030\031\022\ \021\017\r\027\024\020\024 \(\n\036\027\036\036 \274 \024\022\030\031\032\ \027\024)Tj 0 Tw (-)Tj 0.102 Tw 0 -1.218 TD (\f\021\017\) \007\036\235\036\022\021\026 \f\021\036\027\022\017 \r\027\036\ \002\030\033\001\017\027\027\024\020\024 \024\021\007\036\035\026 \023\030\ \016\n\024\005 )Tj 0.241 Tw 0 -1.218 TD (\022\017\001\022\017 \016\r\035\016\036\021\f\016 \r\026\032\027\t\n \220\ \035\036\n\036\027\021\024\n \025\024\027\006\036\023\006\017\017, \027\024\ )Tj 0.005 Tw 0 -1.218 TD (\027\036 \023\030\017\024\030\017\021\036\021\027\t\n. \211\004\017\021\t\ \r\026\033\021\f\016 \f\035\036\007\031\033\013\017\036 \235\026\022\021\ \024\030\t: )Tj 0.159 Tw 0 -1.218 TD (\007\024\f\021\031\023\027\024\f\021\034 \030\026\027\036\027\017\016 \007\ \035\016 \031\001\017\r\026\027\017\016, \024\002\255\036\n \023\024\r\030\ \036\032)Tj 0 Tw (-)Tj 0.067 Tw 0 -1.218 TD [(\007\036\027\017\016, )0.5(\f\024\f\021\024\016\027\017\036 )0.6(\023\026\006\017\036\027\021\026, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 12.527 0 Td [(\021\026\022\032\036 )0.5(\n\036\007\017\022\024-\021\026\022\021\017\004\036)]TJ 0 Tw (-)Tj 0.161 Tw -12.527 -1.218 Td (\f\022\026\016 \024\002\f\021\026\027\024\r\022\026, \024\023\t\021 \b\017\ \030\031\030\020\026. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \r\t\023\024\035\027\036\027\017\016 )Tj 0.134 Tw T* (\007\026\027\027\024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024\ \023\030\017\036\n\026 \027\036\024\002\b\024\007\017\n\024 \017\002\036\ \020\026\021\034 )Tj -0.026 Tw T* (\007\024\023\024\035\027\017\021\036\035\034\027\024\020\024 \023\024\r\030\ \036\032\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\026\n\017\027\026\006\017\017 \022\035\036\021)Tj 0 Tw (-)Tj T* (\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\r \021\ \026\026.)Tj 0.263 Tw T* (\217\031\021\017\027\027\t\005 \b\026\030\026\022\021\036\030 \023\026\030\ \026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\027\017\030\ \024\r\026\027\017\016 )Tj 0.037 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\027\024\020\024 \007\024\f\021\031\023\ \026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \027\036 \023\024\r\024\035\016\036\021 )Tj 0.172 Tw T* (\022\024\027\021\030\024\035\017\030\024\r\026\021\034 \020\035\031\002\017\ \027\031 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\036 \007\030\036\027\026\032\026, \004\021\ \024 )Tj 0.055 Tw T* [(\026\022\024\027\024\n\036\030\027\024 \f\023\024\f\024\002\f\021\r\031\ \036\021 )0.5(\r\t\f\024\022\017\n \030\017\f\022\026\n \016\021\030\024\020\036\027)]TJ 0 Tw (-)Tj 0.051 Tw T* (\027\t\b \023\024\r\030\036\032\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \024\002\036\f\023\036\004\017\r\026\036\021 \027\026\007\036\032\ \027\031\033 \023\030\024)Tj 0 Tw (-)Tj 0.168 Tw T* (\235\017\035\026\022\021\017\022\031 \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\031\033 \007\017\026\020\027\024\f\021\ \017\022\031 \017\027\235\036\022\006\017)Tj 0 Tw (-)Tj T* (\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 [5,7,10].)Tj 0.042 Tw T* (\206\205, \016\r\035\016\016\f\034 \n\024\007\036\035\034\033 \f\036\023\ \f\017\f\026, \031\004\017\021\t\r\026\016 \235\031\035\034\n\017\027\026\ \027\021)Tj 0 Tw (-)Tj 0.005 Tw T* (\027\024\036 \021\036\004\036\027\017\036, \023\030\036\007\f\021\026\r\035\ \016\036\021 \024\007\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \020\030\024\027\t\b )Tj 0.039 Tw T* (\024\f\035\024\032\027\036\027\017\005 \024\020\027\036\f\021\030\036\035\ \034\027\t\b \030\026\027\036\027\017\005 \021\026\026, \f\024\023\030\016\ \032\036\027)Tj 0 Tw (-)Tj 0.149 Tw T* (\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \035\036\021\026\035\034\027\024\f\021\034\033 [2\ ,3]. \215\030\036\007\f\021\026\r\035\036\027\027\t\005 )Tj 0.314 Tw T* (\022\035\017\027\017\004\036\f\022\017\005 \023\030\017\n\036\030 \027\026\ \020\035\016\007\027\024 \007\036\n\024\027\f\021\030\017\030\031\036\021\ , \004\021\024 )Tj 0.459 Tw T* (\f\r\024\036\r\030\036\n\036\027\027\026\016 \007\017\026\020\027\024\f\021\ \017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\026\022\021\017\r\027\026\016 \b\017\030\031\030\020\017)Tj 0 Tw (-)Tj 0.606 Tw T* [(\004\036\f\022\026\016 )0.6(\021\026\022\021\017\022\026, )0.5(\024\023\036\030\036\032\026\033\013\026\016 )0.6(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 )]TJ 0.421 Tw T* (\017\027\235\036\022\006\017\024\027\027\024\020\024 \023\030\024\006\036\ \f\f\026, \016\r\035\016\036\021\f\016 \036\007\017\027\f\021\r\036\027\027\ \t\n )Tj 0.012 Tw T* (\022\035\033\004\024\n \022)Tj /Span<>> BDC ( )Tj EMC (\f\024\b\030\026\027\036\027\017\033 \032\017\027\017 \023\026\006\017\036\ \027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \027\024)Tj 0 Tw (-)Tj T* (\024\035\024\020\017\004\036\f\022\024\005 \235\024\030\n\024\005.)Tj 0.004 Tc 0.228 Tw T* [(\025\024\027\006\036\023\006\017\016 )0.5(\n\027\024\020\024\220\021\026\023\027\024\020\024 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016)4( )]TJ 0.273 Tw T* (\026\022\035\033\004\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\r\t\r\036\030\036\027\027\t\b \027\026\007\036\032\027\t\b \021\026\022\ \021\017\004\036\f\022\017\b)4( )]TJ 0.117 Tw T* [(\030\036\001\036\027\017\016\b. )0.5(\222\024\022\030\026\013\036\027\027\t\005 )0.5(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\005 )0.5(\026\035\020\024\030\017\021\n)4( )]TJ 0.047 Tw T* (\024\002\031\f\035\024\r\035\036\027 \027\036 \024\021\f\031\021\f\021\r\ \017\036\n \f\030\036\007\f\021\r, \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\022\024-\021\026\022\021\017)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.007 Tw T* (\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\030\026\002\024\021\024\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\031\f\035\024\r\017\016\b \n\026\f\f\024\r\024\020\024)4( )]TJ 0.01 Tw T* [(\023\024\f\021\031\023\035\036\027\017\016. \221\026\022, \027\026\023\030\ \017\n\036\030, \b\030\024\027\024\035\024\020\017\004\036\f\022\017\036\ \030\026\n\022\017)4( )]TJ 0.165 Tw T* [(\r\t\023\024\035\027\036\027\017\016 \002\026\022\021\036\030\017\024\035\ \024\020\017\004\036\f\022\017\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 )0.5(\n\024)]TJ 0 Tc 0 Tw (-)Tj 0.004 Tc 0.197 Tw T* (\020\031\021 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\036\f\022\024\035\034\022\024 \030\026 \023\030\036\r\t\001\026\021\ \034 \r\030\036\n\016 \027\026\b\024\032\007\036\027\017\016)4( )]TJ 0.245 Tw T* (\023\026\006\017\036\027\021\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\n \233\204\233, \004\021\024 \016\r\ \035\016\036\021\f\016 \027\036\f\021\036)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.152 Tw T* [(\030\036\024\021\017\023\027\t\n \007\035\016 \253\n\017\030\027\024\005\ \273 \b\017\030\031\030\020\017\017. \216\017\030\031\030\020\017\004\036\ \f\022\024\005)4( )]TJ 0.297 Tw T* [(\022\024\n\026\027\007\036 \024\021\f\035\036\007\017\021\034 \030\036\031\ \035\034\021\026\021 \f\r\024\036\005 \030\026\002\024\021\t \023\024\f\035\ \036)4( )]TJ 0.137 Tw T* (\023\036\030\036\r\024\007\026 \023\026\006\017\036\027\021\026 \027\026\ )Tj /Span<>> BDC ( )Tj EMC [(\f\035\036\007\031\033\013\017\005 \233\204\233 \026\004\026\f\021\031\033\ \027\036)4( )]TJ 0.513 Tw T* (\023\030\036\007\f\021\026\r\035\016\036\021\f\016 \r\024\n\024\032\027\ \t\n \r)Tj /Span<>> BDC ( )Tj EMC [(\f\017\035\031 \024\002\255\036\022\021\017\r\027\t\b)4.1( )]TJ -0.004 Tw T* (\023\030\017\004\017\027.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 176.8198 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.044 Tw 10 0 0 10 303.3071 152.4638 Tm (\212\017\026\020\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\036 \200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233 \016\r\035\016\036\021\f\016 \026\022\021\031)Tj 0 Tw (-)Tj 0.195 Tw T* (\026\035\034\027\024\005 \023\030\024\002\035\036\n\024\005 \f\024\r\030\ \036\n\036\027\027\t\b \r\024\024\030\031\032\036\027\027\t\b \022\024\027\ )Tj 0 Tw (-)Tj 0.107 Tw T* (\235\035\017\022\021\024\r. \216\017\030\031\030\020\017\004\036\f\022\026\ \016 \023\024\n\024\013\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \007\024\035\032\027\026 )Tj 0.132 Tw T* (\017\n\036\021\034 \023\036\030\f\024\027\017\235\017\006\017\030\024\r\026\ \027\027\t\005 \023\024\007\b\024\007, \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017)Tj 0 Tw (-)Tj -0.09 Tw T* (\n\024\f\021\017 \024\021 \b\026\030\026\022\021\036\030\026 \030\026\027\ \036\027\017\016, \f\024\f\021\024\016\027\017\016 \023\026\006\017\036\027\ \021\026, \024\023\t)Tj 0 Tw (-)Tj -0.008 Tw T* (\021\026 \n\036\007\017\006\017\027\f\022\024\020\024 \023\036\030\f\024\ \027\026\035\026, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021 \n\036\007\017\022\024-\021\026\022\021\017\004\036)Tj 0 Tw (-)Tj 0.16 Tw T* (\f\022\024\005 \024\002\f\021\026\027\024\r\022\017. \217\026\002\024\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \n\027\024\020\024\220\021\026\023\027\024\020\ \024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.8652 56.0378 Tm (146)Tj ET endstream endobj 600 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 601 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 602 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 603 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 604 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 665 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\235\t\025\013)10(\025)21(\237\026)11(\017\224\t\025\004 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\004 \020\004\225\004\t\n\004 \224\025\016)-9.9(\026\005\017\202\017\b\204\004\013)10(\025 )]TJ 0 -1 TD [(\016\022\025\013\t\004\016)-9.9(\026\005\004\020\200\t\217\024 \005\017\t\004\t\n\004\024 \b\t\004\255\005\ \206\204\n\t\t\025\013)10(\025 \025\026)11(\202\004\020\017 )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n, \025\016)-10(\020\025\226\t\242\t\t\217\024 \013)10(\017\t\013\005\004\t\025\221 \210\002\005\t\200\004)]TJ 33.406 2 Td [(Multistage sur)31(gical tr)31(eatment of\022a\022victim with a\022gunsh)11(ot w)11(ound of\022th)11(e )]TJ -0.724 -1 Td [(e)21(xtr)21(aperitoneal par)-19.9(t of\022th)11(e r)31(ectum complicated b)10(y F)15(ournier\236)63(s gangr)31(ene)]TJ ET q 42.52 448.349 221.102 288.659 re W n q 221.1023475 0 0 290.0017943 42.5196833 448.2279928 cm /Im0 Do Q Q BT /T1_1 1 Tf -0.022 Tw 9 0 0 9 42.5197 437.5498 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \002\025\023\032\020\031\033\027\032\020\006\022\031\025\025\020\t \n\020\ \032\023\022\025\020: \021\024\n\032\013\023\022\027 \022)Tj /Span<>> BDC ( )Tj EMC (\030\032\027)Tj 0 Tw (-)Tj 0.19 Tw 0 -1.2 TD (\025\022\032\031\021\020\025\022\027 \b\025\031\235\025\031-\025\027\n\032\ \031\023\022\007\027\024\n\031\b\031 \031\007\020\b\020 \026\031\213\031\ \025\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031)Tj 0 Tw (-)Tj T* (\026\027\255\025\031\024\023\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.026 Tw T* [(F)-16(igure )0.5(2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Intraoperativ)13.1(e picture: )0.5(opening and drainag)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC (pu)Tj 0 Tw (-)Tj T* [(rulent-necro)13.1(tic focus of)]TJ /Span<>> BDC ( )Tj EMC [(the scro)13.2(tum and per)-36.9(ineum)]TJ ET q 42.52 100.97 221.102 282.875 re W n q /GS0 gs 221.1023475 0 0 284.2401643 42.5196795 100.8455849 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\n\031\025\007\020\023\027\f\017\025\013\235 \021\022\030 \033\031\024\ \f\027\031\033\027\032\020\006\022\031\025\025\031\235 \032\020\025\013)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 -1.2 TD [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Final appearance of)Tj /Span<>> BDC ( )Tj EMC [(the postoperativ)13.3(e w)12(ound)]TJ ET q 274.961 437.55 221.102 299.458 re W n q /GS0 gs 222.4476172 0 0 300.922376 274.9606323 437.5498524 cm /Im2 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.037 Tw 9 0 0 9 274.9606 426.7498 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\031\024\023\031\t\025\022\027 \033\031\024\f\027\031\033\027\032\020\ \006\022\031\025\025\031\235 \032\020\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (4-\027 \024\r\023)Tj 0 Tw (-)Tj 0 -1.2 TD (\n\022 \033\031\024\f\027 \031\033\027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.012 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC (condition of)Tj /Span<>> BDC ( )Tj EMC [(the postoperativ)13.1(e w)12.1(ound on the)]TJ /Span<>> BDC ( )Tj EMC (4th )Tj 0 Tw T* [(d)26(ay af)-45.9(ter surg)12(er)-43(y)]TJ ET q 274.961 122.57 221.102 261.275 re W n q /GS0 gs 221.1023475 0 0 263.5943325 274.9606228 121.3782113 cm /Im3 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.219 Tw 9 0 0 9 274.9606 111.7701 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\031\024\023\031\t\025\022\027 \033\031\024\f\027\031\033\027\032\020\ \006\022\031\025\025\031\235 \032\020\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (14-\027 )Tj 0 Tw T* (\024\r\023\n\022 \033\031\024\f\027 \031\033\027\032\020\006\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.038 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC (condition of)Tj /Span<>> BDC ( )Tj EMC [(the postoperativ)13(e w)12(ound on the)]TJ /Span<>> BDC ( )Tj EMC (14th )Tj 0 Tw T* [(d)26(ay af)-45.9(ter surg)12(er)-43(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.5273 56.0378 Tm (145)Tj ET 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"ۄ-Q[LtHRJiА'$*UT7+F4Z]e K5&jS BUVS-:RFsa4G!(-=I{5Jٽ 2ThnZklj^URjN}~Y*F]!qQ̞xSʙm CuZod8n[n3sZV^f)@:0p삒\tK8Tw1IJѯ+Y+I%Q2kCUVQe1+2J(S]D jTR^RjTR endstream endobj 673 0 obj <>stream endstream endobj 672 0 obj <>stream endstream endobj 671 0 obj <>stream endstream endobj 670 0 obj <>stream endstream endobj 663 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.388 Tw 10 0 0 10 70.8661 724.8299 Tm (\027\036\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\017\004\036\ \f\022\024\005 \f\017\021\031\026\006\017\036\005, \021\030\036\002\031\033\ \013\036\005 )Tj 0.175 Tw 0 -1.218 TD [(\023\036\030\r\024\024\004\036\030\036\007\027\024\005 \007\017\026\020\027\ \024\f\021\017\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\020\024 \035\036\004\036)Tj 0 Tw (-)Tj 0.093 Tw T* (\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\024\022\026\026\027\017\017 )0.5(\f\r\024\036\r\030\036\n\036\027\027\024\005 \b\017\030\031\030\020\017\004\ \036\f\022\024\005 )]TJ 0.069 Tw T* (\023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \024\002\255\036\n\036 \027\026\002\035\033\007\026\ \036\021\f\016 \002\t\f\021\030\024\036 \030\026\f)Tj 0 Tw (-)Tj T* (\023\030\024\f\021\030\026\027\036\027\017\036 \017\027\235\036\022\006\017\ \017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\022\030\031\032\026\033\013\017\036 \021\022\026\027\017 [2,3].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 639.5839 Tm [(\037\f\031\032\026\022\031\034)5( \032\r\224\225\026\025)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.152 Tw 10 0 0 10 70.8661 615.2279 Tm [(\215\026\006\017\036\027\021 )0.5(\216. )0.6(\023\024\035\031\004\017\035 )0.5(\024\f\022\024\035\024\004\027\024\036 )0.6(\030\026\027\036\027\017\036 )0.5(\r\t\f\024\022\024\022\017)]TJ 0 Tw (-)Tj 0.199 Tw T* (\027\036\021\017\004\036\f\022\017\n \030\026\027\016\013\017\n \220\035\ \036\n\036\027\021\024\n. \200)Tj /Span<>> BDC ( )Tj EMC (\022\024\030\024\021\022\017\036 \f\030\024\022\017 )Tj 0.033 Tw T* (\007\024\f\021\026\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023 \022\r\026\035\017\235\017\006\017\030\024\r\026\027\027\ \024\005 \n\036\007\017\006\017\027\f\022\024\005 )Tj 0.133 Tw 0 -1.218 TD (\023\024\n\024\013\017 \(2 \211\204\215\), \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \024\002\f\035\036\007\024\r\026\027\017\016 \031\f\021\026\ \027\024\r)Tj 0 Tw (-)Tj -0.041 Tw 0 -1.218 TD (\035\036\027 \007\017\026\020\027\024: \222\024\004\036\021\026\027\027\ \024\036 \024\f\022\024\035\024\004\027\024\036 \030\026\027\036\027\017\ \036 \020\024\035\024\r\t, )Tj 0.177 Tw 0 -1.218 TD [(\021\026\026, \022\024\027\036\004\027\024\f\021\036\005. \222\035\036\023\ \024\036 )0.5(\027\036\023\030\024\027\017\022\026\033\013\036\036 \030\026\027\036\027\ \017\036 )]TJ 0.046 Tw T* (\020\024\035\024\r\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\f\024\004\027\024\005 \024\002\035\026\f\021\017 \f\023\030\026\r\ \026. \222\035\036\023\024\036 \023\030\024\027\017\022\026)Tj 0 Tw (-)Tj 0.009 Tw T* (\033\013\036\036 \030\026\027\036\027\017\036 \023\030\024\n\036\032\027\ \024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\030\036\032\007\036\027\017\036\n \023\030\016\n\024\005 )Tj 0.142 Tw T* (\022\017\001\022\017. \204\027\024\032\036\f\021\r\036\027\027\024\036 \f\ \035\036\023\024\036 \030\026\027\036\027\017\036 \024\002\036\017\b \027\ \017\032)Tj 0 Tw (-)Tj 0.119 Tw T* (\027\017\b \022\024\027\036\004\027\024\f\021\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\027\017\022\026\033\013\017\n \030\026\027\036\027\017\036\n\ \023\030\026\r\024\020\024 )Tj 0.157 Tw T* (\022\024\035\036\027\027\024\020\024 \f\031\f\021\026\r\026. \215\026\006\ \017\036\027\021\031 \r\t\023\024\035\027\036\027\t \023\026\035\034\006\ \036\r\024\036 )Tj 0.248 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\n\024\021\030 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026\035\026\b, )Tj 0.149 Tw T* (\r\t\016\r\035\036\027\024 \027\036\007\036\f\021\030\031\022\021\017\r\027\ \024\036 \(\n\036\027\036\036 1/4 \024\022\030\031\032\027\024\f\021\017\ \) )Tj 0.196 Tw T* [(\030\026\027\036\027\017\036 \f\030\036\007\027\036\026\n\023\031\035\016\ \030\027\024\020\024 )0.5(\024\021\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017. )]TJ 0.013 Tw T* (\200\t\023\024\035\027\036\027\024 \027\036\024\021\035\024\032\027\024\036\ \024\023\036\030\026\021\017\r\027\024\036 \r\n\036\001\026\021\036\035\ \034\f\021\r\024. )Tj 0.299 Tw T* (\230)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\024\022\024\035\026 \024\023\036\030\026\006\017\017: \253\ \246\r\t\023\024\035\027\036\027\026 \f\030\036\007\017\027\027\026\016 \ )Tj 0.267 Tw T* (\035\026\023\026\030\024\021\024\n\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \023\026\021\024\ \035\024\020\017\004\036\f\022\024\020\024 )Tj 0.406 Tw T* (\024\021\007\036\035\016\036\n\024\020\024 \027\036\021, \023\024\r\030\036\ \032\007\036\027\017\005 \024\030\020\026\027\024\r \002\030\033\001\027\ \024\005 )Tj 0.233 Tw T* (\023\024\035\024\f\021\017 \027\036\021. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\r\017\017\017 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026)Tj 0 Tw (-)Tj 0.207 Tw T* [(\035\026\b )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 3.235 0 Td [(12 )0.5(\004\026\f\026\b )0.6(\031\f\035\024\r\027\024\020\024 )0.5(\006\017\235\036\030\002\035\026\021\026 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 15.608 0 Td [(7 )0.5(\f\n )0.5(\024\021 )]TJ 0.331 Tw -18.843 -1.218 Td (\026\027\026\035\034\027\024\020\024 \032\024\n\026 \r\017\031\026\035\017\ \017\030\024\r\026\027\024 \030\026\027\036\027\017\036 \f\021\036\027\022\ \017 )Tj 0.13 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 0,5)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (0,3 \f\n. \217\026\027\026 \031\001\017\021\026. \200\t\023\024\035\027\036\ \027\024 )Tj 0.289 Tw T* (\002\017\035\026\021\036\030\026\035\034\027\024\036 \023\026\030\026\030\ \036\022\021\026\035\034\027\024\036 \007\030\036\027\017\030\024\r\026\027\ \017\036 \023\030\024)Tj 0 Tw (-)Tj 0.394 Tw T* [(\n\036\032\027\024\f\021\027\t\n )0.6(\007\024\f\021\031\023\024\n. )0.5(\222\235\024\030\n\017\030\024\r\026\027\026 )0.5(\f\017\020\n\024\f\021\024\n\026 )]TJ 0.279 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\r\t\r\036\007\036\027\017\036\n \023\030\024\022\f\017\n\026\035\034\027\ \024\020\024 )0.5(\024\021\007\036\035\026, \007\017\f\021\026\035\034\027\t\005 )]TJ 0.045 Tw T* (\030\036\022\021\024\f\017\020\n\024\017\007\027\t\005 \024\021\007\036\035\ \021\024\035\f\021\024\005 \022\017\001\022\017 \031\001\017\021 \027\026\ \020\035\031\b\024 )Tj -0.037 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\020\030\031\032\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\031\033 \023\024\035\024\f\021\034. \200\t\023\024\035\ \027\036\027\024 \007\030\036\027\017\030\024)Tj 0 Tw (-)Tj 0.065 Tw T* [(\r\026\027\017\036 )0.5(\n\026\035\024\020\024 )0.6(\021\026\026. )0.5(\215\024\f\035\024\005\027\024\036 )0.6(\031\001\017\r\026\027\017\036 )0.5(\035\026\023\026\030\024\021\024\n)]TJ 0 Tw (-)Tj -0.048 Tw T* (\027\024\005 \030\026\027\t\246\273. \212\026\035\036\036 \f\026\027\017\ \021\026\030\027\t\n \021\030\026\027\f\023\024\030\021\024\n \007\024\f\ \021\026\r)Tj 0 Tw (-)Tj -0.034 Tw T* (\035\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\006\017\027\f\022\031\033 \024\030\020\026\027\017\026\006\ \017\033 3 \211\204\215, \020\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 )Tj 0.032 Tw T* (\007\r\031\b \f\031\021\024\022 \023\024\035\031\004\026\035 \022\024\027\ \f\036\030\r\026\021\017\r\027\024\036 \035\036\004\036\027\017\036. \203\ \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\036)Tj 0 Tw (-)Tj 0.197 Tw T* (\021\034\017 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017 \220\r\026\022\031\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\002\027\024\036 )Tj 0.238 Tw T* [(\031\004\030\036\032\007\036\027\017\036 )0.6(4 )0.5(\211\204\215, )0.5(\020\024\f\023\017\021\026\035\017\017\030\024\r\026\027 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.83 0 Td (\024\021\007\036\035\036\027\017\036 )Tj 0.237 Tw -17.83 -1.218 Td (\027\036\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\017\017.\ \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\031\023\035\036\027\017\017 \f\024\f\021\024\016\027\017\036\ )Tj 0.063 Tw 0 -1.218 TD (\f\030\036\007\027\036\005 \f\021\036\023\036\027\017 \021\016\032\036\f\ \021\017, \032\026\035\024\002\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.195 Tw 0 -1.218 TD [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )0.5(\030\026\027, \n\036\f\021\026\b \f\021\024\016\027\017\016 \007\030\036\ \027\026\032\036\005, )]TJ -0.014 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \n\024\001\024\027\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\n\024\021\030\036: \035\026\023\026\030\024\021\024\n\027\026\016\ \030\026\027\026 )Tj 0.215 Tw T* (\002\036 \024\f\024\002\036\027\027\024\f\021\036\005, \022\017\001\036\ \004\027\026\016 \f\021\024\n\026 \235\031\027\022\006\017\024\027\017\030\ \031\036\021, )Tj 0.07 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\026\032\026\n \017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\020\024 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\ )Tj 0 Tw (-)Tj -0.009 Tw T* (\004\026\021\022\017 \f\035\036\007\t \f\036\030\024\027\024-\020\036\n\ \024\030\030\026\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\016\ \036\n\024\020\024. )Tj 0.195 Tw T* (\204\024\001\024\027\022\026 \002\026\020\030\024\r\024-\006\017\026\027\ \024\021\017\004\027\024\020\024 \006\r\036\021\026, \027\026\004\017\021\ \036\035\034\027\024 )Tj 0.155 Tw T* (\031\r\036\035\017\004\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\036\030\026\b, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\023\026\006\017\017 \030\036\022\024 \002\024\035\036\ )Tj 0 Tw (-)Tj T* (\027\036\027\027\026\016, \022\030\036\023\017\021\017\030\031\036\021 \(\ \217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj -0.057 Tw T* [(\217\036\022\021\026\035\034\027\024: )0.6(\f\235\017\027\022\021\036\030 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.446 0 Td [(\021\024\027\031\f\036, )0.5(\f\035\036\007\t )0.6(\022\026\035\026 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.953 0 Td (\023\036\030\004\026\021\022\036 )Tj -0.01 Tw -18.399 -1.218 Td (\022\024\030\017\004\027\036\r\024\020\024 \006\r\036\021\026 \f\024 \f\035\ \036\007\026\n\017 \235\017\002\030\017\027\024\027\024-\020\027\024\005\ \027\024\020\024 )Tj 0.01 Tw 23.244 64.543 Td (\024\021\007\036\035\016\036\n\024\020\024 \f)Tj /Span<>> BDC ( )Tj EMC (\017\b\024\030\024\027\t\n \026\023\026\b\024\n. \221\036\n\023\036\030\ \026\021\031\030\026 \021\036\035\026 )Tj 0 Tw T* (37,8)Tj /Span<>> BDC ( )Tj EMC 5.83 0 0 5.83 321.407 715.9819 Tm (\260)Tj 0.411 Tw 10 0 0 10 324.322 712.6519 Tm (\222. \202\030\021\036\030\017\026\035\034\027\024\036 \007\026\r\035\036\ \027\017\036 110/70 \n\n \030\021.\f\021. )Tj 0.162 Tw -2.102 -1.218 Td [(\215\031\035\034\f )0.5(95 )0.5(\031\007./\n\017\027. )0.5(\232\026\f\021\024\021\026 )0.5(\007\t\b\026\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 15.662 0 Td [(\227 )0.5(18 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.657 0 Td [(1 )0.5(\n\017\027. )]TJ 0.407 Tw -19.32 -1.218 Td (\214\026\002\024\030\026\021\024\030\027\024: \020\036\n\024\020\035\024\ \002\017\027 119 \020/\035, \035\036\005\022\024\006\017\021\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.177 Tw T* (16,0)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 343.3089 679.4479 Tm (9)Tj 0.177 Tw 10 0 0 10 346.2239 676.1179 Tm [(/\035. \200\t\023\024\035\027\036\027\026 )0.5(\007\017\f\021\026\035\034\027\026\016 )0.5(\022\024\035\024\027\024\f\022\024\023\017\016: )]TJ 0.035 Tw -4.292 -1.218 Td (\024\f\n\024\021\030\036\027\024 40 \f\n \022\017\001\022\017, \022\031\035\ \034\021\016 \f\024\f\021\024\016\021\036\035\034\027\026, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007)Tj 0 Tw (-)Tj 0.31 Tw T* (\027\036\026\n\023\031\035\016\030\027\024\n \024\021\007\036\035\036 \023\ \030\016\n\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\027\036\005 )Tj 0.242 Tw 0 -1.218 TD [(\f\021\036\027\022\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.646 0 Td [(5 )0.5(\f\n )0.5(\024\021 )0.5(\026\027\024\030\036\022\021\026\035\034\027\024\020\024 )0.5(\023\036\030\036\b\024\007\026 )0.6(\024\023\030\036)]TJ 0 Tw (-)Tj 0.279 Tw -4.646 -1.218 Td (\007\036\035\016\036\021\f\016 \007\036\235\036\022\021 \f\021\036\027\022\ \017 \023\030\016\n\024\005 \022\017\001\022\017 \030\026\n\036\030\026\ \n\017 )Tj 0.041 Tw T* (0,4)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (0,4 \f\n, \023\024\022\030\t\021 \235\017\002\030\017\027\024\n. \211\004\ \017\021\t\r\026\016 \007\026\027\027\t\036 \024\002)Tj 0 Tw (-)Tj 0.118 Tw 0 -1.218 TD (\f\035\036\007\024\r\026\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\035\017\027\017\004\036\f\022\031\033 \022\026\ \030\021\017\027\031, \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\021)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD [(\035\024\032\027\t\n \023\024\022\026\026\027\017\016\n )0.5(\023\026\006\017\036\027\021\031 \r\t\023\024\035\027\036\027\026 \024\023\ \036\030\026\006\017\016: )]TJ 0.174 Tw 0 -1.218 TD [(\r\f\022\030\t\021\017\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.186 0 Td [(\007\030\036\027\017\030\024\r\026\027\017\036 )0.6(\020\027\024\005\027\024\020\024 )0.5(\024\004\026\020\026 )0.6(\n\024\001\024\027\022\017 )]TJ 0.329 Tw -5.186 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017. \230)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\024\022\024\035\026 \024\023\036\030\026\006\017\017: \253\ \246\023\030\024)Tj 0 Tw (-)Tj 0.338 Tw 0 -1.218 TD (\007\024\035\034\027\t\n \035\017\027\036\005\027\t\n \030\026\030\036\ \024\n \r\t\023\024\035\027\036\027\024 \001\017\030\024\022\024\036 )Tj 0.084 Tw 0 -1.218 TD (\030\026\f\f\036\004\036\027\017\036 \022\024\032\017 \n\024\001\024\027\ \022\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \027\036\017\n\036\027\036\027\027\t\b )Tj 0.252 Tw 0 -1.218 TD (\021\022\026\027\036\005, \023\024\035\031\004\036\027\024 \007\024)Tj /Span<>> BDC ( )Tj EMC (100 \n\035 \235\017\002\030\017\027\024\027\024-\020\027\024\005\027\024\ \020\024 )Tj 0.183 Tw 0 -1.218 TD [(\024\021\007\036\035\016\036\n\024\020\024 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 6.465 0 Td [(\017\b\024\030\024\027\t\n )0.6(\026\023\026\b\024\n. )0.5(\221\022\026\027\017 )0.6(\n\024\001\024\027\022\017 )]TJ 0.062 Tw -6.465 -1.218 Td (\027\036\022\030\024\021\017\004\036\f\022\017 \017\n\036\027\036\027\t\ , \021\031\f\022\035\024\020\024 \021\036\n\027\024\020\024 \006\r\036\021\ \026, \r\024)Tj 0 Tw (-)Tj 0.088 Tw 0 -1.218 TD [(\007\016\027\017\f\021\t\036. )0.5(\222\022\036\035\036\021\017\030\024\r\026\027\t )0.5(\024\002\026 \016\017\004\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\036\n\036\027\027\t\036 \022\026)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\027\026\021\017\022\017, \023\030\017\027\026\027\t \032\017\027\036\f\ \023\024\f\024\002\027\t\n\017. \203\036\022\030\024\021\017\004\036\f\022\ \017\005 )Tj 0.059 Tw 0 -1.218 TD (\023\030\024\006\036\f\f \030\026\f\023\030\024\f\021\030\026\027\016\036\ \021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\034, \022)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD (\027\036\005 \f\021\036\027\022\036 \027\017\032\027\036\026\n\023\031\035\ \016\030\027\024\020\024 \024\021\007\036\035\026 \023\030\016\n\024\005\ \022\017\001\022\017. )Tj -0.023 Tw T* (\203\036\022\030\024\021\017\004\036\f\022\017 \017\n\036\027\036\027\027\ \026\016 \022\035\036\021\004\026\021\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\032\026 \n\024\001\024\027\022\017 )Tj 0.111 Tw 0 -1.218 TD (\017\f\f\036\004\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \007\024\030\024\r\t\b \021\022\026\027\036\ \005. \221\031\026\035\036\021 \030\026\027\t )Tj 0.268 Tw 0 -1.218 TD (\030\026\f\021\r\024\030\026\n\017 \026\027\021\017\f\036\023\021\017\022\ \024\r. \217\t\b\035\024\036 \021\026\n\023\024\027\017\030\024\r\026\027\ \017\036 )Tj 0.001 Tw 0 -1.218 TD [(\030\026\027\t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 2.996 0 Td [(\030\026\f\021\r\024\030\024\n )0.6(\023\024\r\017\007\024\027-\005\024\007\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.374 0 Td [(\n\026\034\033 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.017 0 Td (\r\024\007\024\030\026\f)Tj 0 Tw (-)Tj 0.134 Tw -18.387 -1.218 Td (\021\r\024\030\017\n\024\005 \024\f\027\024\r\036. \213\007\017\027\017\004\ \027\t\005 \001\024\r \022\024\032\017 \007\035\016 \235\017\022\f\026)Tj 0 Tw (-)Tj 0.283 Tw 0 -1.218 TD (\006\017\017 \023\024\r\016\022\017. \217\036\021\030\024\020\030\026\007\ \027\024\036 \007\017\f\021\026\035\034\027\024\036 \024\021\n\t\r\026\027\ \017\036 )Tj 0 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017\273 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2, 3\).)Tj 0.003 Tw 0 -1.218 TD (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \023\026\006\017\036\027\021 \023\024\035\031\004\ \026\035 \022\024\027)Tj 0 Tw (-)Tj 0.085 Tw 0 -1.218 TD (\f\036\030\r\026\021\017\r\027\031\033 \021\036\030\026\023\017\033 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\007\031\033\013\017\n \027\026\023\030\026\r\035\036\027\017\016\ \n: )Tj ET q 303.307 122.57 221.102 205.917 re W n q /GS0 gs 221.1023475 0 0 205.9780881 303.307086 122.5097284 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.118 Tw 9 0 0 9 303.3071 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \215\027\024\023\025\013\235 \024\023\020\023\r\024 \025\020)Tj /Span<>> BDC ( )Tj EMC (3-\022 \024\r\023\n\022 \033\031\024\f\027 \033\027\032\021\031\b\031 )Tj 0 Tw 0 -1.2 TD (\031\033\027\032\020\023\022\021\025\031\b\031 \021\026\027\213\020\023\027\ \f\017\024\023\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.117 Tw T* [(F)-16(igure )0.6(1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(Local )0.6(status )0.5(on )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 12.276 0 Td [(3rd )0.5(d)26(ay )0.6(af)-46(ter )0.6(the)]TJ /Span<>> BDC ( )Tj EMC 7.267 0 Td [(f)-43(irst )0.6(surgical )]TJ 0 Tw -19.543 -1.2 Td [(inter)-41.9(v)12.9(entio)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.9403 56.0378 Tm (144)Tj ET endstream endobj 664 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   y!1AQ"aq#2$cs 3BCSr%&'()*456789:DEFGHIJRTUVWXYZbdefghijtuvwxyz!1AQ"aq2BRb#r $%&'()*3456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz?dn, YqM.̬qI5qyO4@.1;a g>ʞ狈ӟFJ D=zuef*"YBt5o[v {<Ut {neunuHPBf)ه!Ӝz"HHNRb8,m+*x֭sKg?R\F:i=OKCӛ[NmmXXx[V t-;r)nWE SԈ(KsYKQk֕s՛|Y:CH%SK1n(>kYt wS]쩮{8r `Nzb3>"{n b^rS%AvitU`Y_xX)9JjIf(tDh݌v ֣RY֋ 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378.6986 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 5.83 0 0 5.83 42.5197 733.048 Tm (2)Tj 0.023 Tw /Span<>> BDC 10 0 0 10 45.8311 729.718 Tm ( )Tj EMC 0.125 0 Td [(1)112(602 Militar)-30.9(y Clinical Hospital \(Dachnay)21(a\022)-23.2(st., 1)75(0, Rostov)-51.9(-on-Don, 3)58(4406)34.1(4, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 721.0481 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 717.7181 Tm [(St. P)10(eter)20.1(sbur)31(g Medical and social institute \(K)41(ondr)21.1(atie)11(v)10(sky A)20(v)12(e., 7)58.1(2, let)-20(ter A)-31(, St. P)10(eter)20(sbur)31(g, 1)138(9)46(5)35(2)46(7)127(1)69(, Russia\))]TJ /T1_1 1 Tf -0.016 Tw 9 0 0 9 90.7087 699.2141 Tm [(AIM: to p)46(resent a clinical case of e)-15(xtraper)-36.9(itoneal rectal w)12(ound com)16(plicated by F)12(our)-13.9(nier\222)37(s g)11.9(ang)14.1(rene, within the frame)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD [(w)12(ork of multi-stag)12.1(e surgical treatment.)]TJ 0.025 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: patient H., sustained a shrapnel w)12(ound to the per)-37(ineum with non-destructiv)13(e e)-15(xtraper)-37(ito)]TJ 0 Tw (-)Tj 0.062 Tw T* [(neal )0.6(d)26(amag)12(e )0.5(to )0.5(the )0.6(middle )0.6(rectum. )0.5(A)14.1(t )0.5(the )0.5(2nd )0.5(lev)13(el )0.6(of )0.5(medical )0.6(care, )0.6(surgical )0.5(treatment )0.5(included )0.6(end )0.5(sigmostom)11(y)42(, )]TJ 0.031 Tw T* [(sutur)-37(ing of the rectal w)12(ound, bilateral pararectal drainag)12.1(e. Three d)26(ays af)-45.9(ter)61(, a surgical inter)-42(v)13(ention w)13(as per)-34(for)-13.9(med )]TJ 0.007 Tw 0 -1.111 TD [(at )0.5(the )0.5(4th )0.5(lev)13(el )0.5(of )0.5(medical )0.5(care )0.6(for )0.5(the dev)13.1(eloped )0.5(com)16(plication)]TJ /Span<>> BDC ( )Tj EMC 24.63 0 Td [(\227 )0.5(F)12(our)-14(nier\222)37(s )0.5(g)12(ang)14(rene. )0.5(On )0.5(the )0.5(14th )0.5(d)26(ay)42(, )0.5(the )0.5(patient )]TJ 0.023 Tw -24.63 -1.111 Td [(w)13(as discharg)12.1(ed for outpatient treatment.)]TJ 0.065 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: this )0.5(clinical case )0.5(show)12(ed that the end colostom)11.1(y in case of )0.5(non-destructiv)13(e e)-15(xtraper)-37(itoneal rectal injur)-42.9(y )]TJ 0.07 Tw T* [(became the reason for refusing to per)-34(for)-13.9(m an im)16(por)-40(tant element of the 4D concep)13(t)]TJ /Span<>> BDC ( )Tj EMC [(\227 anteg)14(rade distal w)13(ashout. )]TJ 0.056 Tw T* [(Thus, the )0.5(unsanitized )0.5(disconnected )0.5(section )0.5(of )0.5(the rectum )0.5(most lik)17.1(ely became the source of a for)-13.9(mid)26(able com)16(plica)]TJ 0 Tw (-)Tj 0.005 Tw T* (tion)Tj /Span<>> BDC ( )Tj EMC [(\227 F)12(our)-13.9(nier\222)37(s g)12(ang)14(rene. In addition, sutur)-36.9(ing the defect of the rectal w)13(all in this clinical case w)13(as no)13(t a p)46(r)-36.9(ior)-37(ity )]TJ 0.048 Tw T* [(element of the 4D concep)13(t, and routine pararectal drainag)12.1(e did no)13(t hav)13(e a signif)-43(icant im)16(pact on the p)45.9(rev)13(ention of )]TJ 0.023 Tw T* [(infectious com)16(plications.)]TJ 0.007 Tw T* [(C)21(ON)22(CLUSION: e)-15(xtraper)-36.9(itoneal rectal w)12(ounds are associated with a high r)-37(isk of dev)13(eloping life-threatening com)16(plica)]TJ 0 Tw (-)Tj 0.052 Tw 0 -1.111 TD [(tions. Surgical treatment of this categor)-43(y of victims at v)16(ar)-36.9(ious stag)12(es of medical ev)16(acuation should be based on a )]TJ 0.006 Tw 0 -1.111 TD [(personalized app)46(roach, depending on the nature of the injur)-42.9(y)42(, the patient\222)37(s condition, the e)-15(xper)-37(ience of the medical )]TJ -0.015 Tw T* [(staf)-40(f, and the medical tactical situation. Despite the dif)-40(f)-43(iculties in continuity betw)12(een the stag)12(es of medical ev)16(acua)]TJ 0 Tw (-)Tj -0.032 Tw T* [(tion in the system of multi-stag)12.1(e surgical treatment, timely diagnosti\024s and treatment of com)16(plications can minimize )]TJ 0.023 Tw T* [(the conseq)14.1(uences of combat surgical trauma.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 503.9449 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc -0.026 Tw 4.948 0 Td [( F)12(our)-14(nier\222)37(s g)12(ang)14(rene; necro)13(tizing sof)-46(t tissue infection; e)-15(xtraper)-37(itoneal rectal injur)-36.9(ies; gunsho)13(t w)12(ound; multi-stag)12.1(e surgical treatment.)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.05 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.059 Tw 6.494 0 Td [( E)-25.2(s)-22.9(e)-18(l)-23.7(e)-15.8(v)-51.8(i)-5(c)-10.2(h)]TJ /Span<>> BDC ( )Tj EMC [(R)-21.4(.)40.6(V)39.7(.)-23.5(, S)-27.1(a)-9.6(m)-12.4(o)-15.2(k)-16.7(h)-14.1(i)-3.1(n)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)-9.8(I)-10.3(.)-23.5(, A)-11.7(l)-16.7(i)-3.2(m)-12.4(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(P)107.7(.)-23.9(A)-23(.)-23.5(, B)-16.4(a)-11.4(l)-23.3(u)-7.6(r)-30.8(a)]TJ /Span<>> BDC ( )Tj EMC [(O)11.4(.)40.6(V)39.7(.)-23.5(, R)-6.5(u)-7(m)-15.4(y)-24.2(a)-7.6(n)-17.3(t)-48.9(s)-22.9(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-1.9(N)-2.8(.)-23.5(, S)-12.1(u)-7.6(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-22.9(. M)-5.7(u)-8.4(l)-15.3(t)-46.3(i)-7.3(s)-29.3(t)-36.8(a)-10.8(g)-14.4(e s)-8.8(u)-7.6(r)-16.7(g)-28.8(i)-5(c)-21.5(a)-11.4(l t)-30.8(r)-19.1(e)-13(a)-18.1(t)-26.2(m)-16.5(e)-11.5(n)-17.3(t)23( )]TJ 0.045 Tw -6.499 -1.2 Td [(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(v)-51.8(i)-5(c)-41.4(t)-46.3(i)-3.1(m w)-45.7(i)-15.8(t)-26.1(h a)]TJ /Span<>> BDC ( )Tj EMC [(g)-9.5(u)-5(n)-11.2(s)-8.8(h)-10.9(o)-15.8(t w)-13.5(o)-13.3(u)-5(n)-14.5(d o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e e)-33.1(x)-44.8(t)-30.8(r)-30.8(a)-8.8(p)-24.7(e)-12.1(r)-56.3(i)-15.8(t)-21.9(o)-9.2(n)-16.1(e)-13(a)-11.4(l p)-20(a)-10.2(r)-59.7(t o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e r)-19.1(e)-19.1(c)-41.5(t)-22.2(u)-7(m c)-6.5(o)-9.2(m)-5.2(p)-20.1(l)-16.7(i)-5(c)-21.5(a)-18.2(t)-24.7(e)-21(d b)-20(y F)-21(o)-13.3(u)-7.6(r)-35.9(n)-14(i)-11(e)-12.1(r)-63.5(\241)20.6(s g)-8.1(a)-7.6(n)-11.9(g)-13.5(r)-19.1(e)-11.4(n)-16.2(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)13.9(ol)3.7(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.9(.)]TJ /T1_3 1 Tf 0 Tc 0 Tw 56.693 0 Td ( )Tj 0.023 Tc 0.024 Tw -56.693 -1.2 Td [(2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)12.5(4)-14.1(2)9.8(\226)50.8(1)12.5(4)-35(8)-11.1(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.6(s)-8.1(:)2(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.4(-)41.3(7)10.7(55)-9(6)-26.7(-)9.8(2)-9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.1(1)26.9(-)55.1(1)12.5(4)-14.1(2)12.1(-)55.1(1)12.5(4)-35(8)]TJ /T1_2 1 Tf 0.01 Tc 0.005 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.01 Tw 10.551 0 Td ( \036\024\027\f\027\021\022\007 \206\031\026\020\025 \211\f\020\030\022\026\ \022\032\031\021\022\007, \214\216\221\211\217\210 \211\217 \253\211\031\ \027\025\025\031-\026\027\030\022\006\022\025\024\n\020\t \020\n\020\030\ \027\026\022\t \022\026\027\025\022 \205.\215.)Tj /Span<>> BDC ( )Tj EMC (\202\022\032\031\021\020\273 \215\022\025\022\024\023\027\032\024\023\021\ \020 )Tj 0.177 Tw -10.556 -1.2 Td (\031\240\031\032\031\025\013 \206\031\024\024\022\235\024\n\031\235 \214\ \027\030\027\032\020\006\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\003\n\020\030\027\026\022\n\020 \035\027\240\027\030\027\021\020, \030.\ )Tj /Span<>> BDC ( )Tj EMC (6, \205\020\025\n\023-\004\027\023\027\032\240\r\032\b, \206\031\024\024\ \022\t, 194044; \023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(911\) 128-21-05; \027-mail: )Tj 0 Tw 0 -1.2 TD (r_eselevich@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.005 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19.1(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.01 Tw 14.025 0 Td [( Eselevich R)19(oman Vladimirovich, Militar)-42.9(y Medical Academ)11(y named af)-46(ter S.M.)]TJ /Span<>> BDC ( )Tj EMC [(Kirov)63.1(, Academica Lebedev)16.1(a st., 6, )]TJ 0.023 Tw -14.03 -1.2 Td [(Saint P)15(etersburg, R)22(ussia, 194044; tel.:)]TJ /Span<>> BDC ( )Tj EMC (+7 \(911\) 128-21-05; e-mail: r_eselevich@mail.ru)Tj 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 10.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 10.09.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 322.9559 Tm [(\026\027)10(\024)-10(\224)62(\026)-10(\r\237\022\037\032\024\237)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.157 Tw 10 0 0 10 42.5197 298.5999 Tm [(\221\026\022\021\017\022\026 \b\017\030\031\030\020\017\004\036\f\022\024\ \005 )0.5(\023\024\n\024\013\017 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\b )Tj 0.155 Tw 0 -1.218 TD (\030\026\027\036\027\017\016\b \023\030\016\n\024\005 \022\017\001\022\017\ \(\200\002\217\215\025\) \016\r\035\016\036\021\f\016 \026\022\021\031\026\ \035\034)Tj 0 Tw (-)Tj 0.211 Tw T* (\027\024\005 \023\030\024\002\035\036\n\024\005 \f\024\r\030\036\n\036\027\ \027\t\b \r\024\036\027\027\t\b \022\024\027\235\035\017\022\021\024\r. \ )Tj -0.003 Tw T* (\204\036\021\024\007\t \035\036\004\036\027\017\016 \030\026\027\036\027\ \017\005 \023\030\016\n\024\005 \022\017\001\022\017 \026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \004\036\n )Tj 0.375 Tw T* [(\f\021\024\035\036\021\027\017\005 \023\036\030\017\024\007 )0.5(\220\r\024\035\033\006\017\024\027\017\030\024\r\026\035\017 \024\021 \r\ \t\032\017\007\026)]TJ 0 Tw (-)Tj 0.077 Tw T* [(\021\036\035\034\027\024\005 )0.6(\021\026\022\021\017\022\017 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC 8.395 0 Td [(\002\024\035\036\036 )0.5(\026\022\021\017\r\027\024\020\024 )0.6(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )]TJ 0.275 Tw -8.395 -1.218 Td (\023\024\007\b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\030\026\002\024\021\022\017 4D-\022\024\027\006\036\023\006\017\ \017, \r\022\035\033\004\026\033\013\036\005 )Tj 0.159 Tw T* [(\004\036\021\t\030\036 \024\f\027\024\r\027\t\b \220\035\036\n\036\027\021\ \026: di)-15.9(ver)-10(sion)]TJ /Span<>> BDC ( )Tj EMC (\227 \024\021\r\036\007\036\027\017\036, )Tj 0.515 Tw T* [(debr)-37(idement)]TJ /Span<>> BDC ( )Tj EMC [(\227 \b\017\030\031\030\020\017\004\036\f\022\026\016 )0.5(\024\002\030\026\002\024\021\022\026, dr)-33(ain)]TJ 0 Tw (-)Tj 0.143 Tw T* [(a)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(\227 \007\030\036\027\017\030\024\r\026\027\017\036, dist)15(al w)-11.9(ashout)]TJ /Span<>> BDC ( )Tj EMC (\227 \007\017\f\021\026\035\034\027\024\036 )Tj 0.209 Tw T* (\024\021\n\t\r\026\027\017\036. \216\017\030\031\030\020\017\004\036\f\022\ \017\036 \023\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\033 \023\024)Tj 0 Tw (-)Tj T* (\f\021\030\026\007\026\r\001\017\b \f)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \007\024\f\021\026\021\024\004\027\024 \030\026\027\ \024\030\024\007\027\t [5\2268].)Tj 0.074 Tw T* (\200 \f\017\f\021\036\n\036 \035\036\004\036\002\027\024-\220\r\026\022\031\ \026\006\017\024\027\027\024\020\024 \024\002\036\f\023\036\004\036\027\017\ \016 \r\024)Tj 0 Tw (-)Tj 0.109 Tw T* (\005\f\022 \r\t\007\036\035\016\033\021 5 \031\030\024\r\027\036\005 \024\ \022\026\026\027\017\016 \n\036\007\017\006\017\027\f\022\024\005 \023\024\ )Tj 0 Tw (-)Tj 0.438 Tw T* (\n\024\013\017 \(\211\204\215\). \025\r\026\035\017\235\017\006\017\030\024\ \r\026\027\027\031\033 \b\017\030\031\030\020\017\004\036\f\022\031\033 \ )Tj 0.187 Tw T* (\023\024\n\024\013\034 \023\024\f\021\030\026\007\026\r\001\017\005 \023\ \024\035\031\004\026\036\021, \027\026\004\017\027\026\016 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\026 2 )Tj 0.226 Tw T* (\211\204\215, \022\024\021\024\030\t\005 \004\026\013\036 \r\f\036\020\024\ \n\026\022\f\017\n\026\035\034\027\024 \023\030\017\002\035\017\032\036\ \027 )Tj 0.114 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \023\030\024\r\036\007\036\027\017\016 \002\024\036\r\t\b \ \007\036\005\f\021\r\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\031)Tj 0 Tw (-)Tj 0.362 Tw T* [(\036\021\f\016 )0.5(\024\023\030\026\r\007\026\027\024 )0.6(\024\020\030\026\027\017\004\036\027\027\t\n\017 )0.6(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\n\017 )]TJ 0.445 Tw 23.244 24.356 Td (\r\024\n\024\032\027\024\f\021\016\n\017. \003\026\007\026\004\036\005 \ \007\026\027\027\024\020\024 \220\021\026\023\026 \016\r\035\016\036\021\ \f\016 )Tj 0.133 Tw T* (\f\024\b\030\026\027\036\027\017\036 \032\017\027\017. \200)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \022\024\027\006\036\023\006\017\017 \n\027\024\020\ \024\220\021\026\023)Tj 0 Tw (-)Tj 0.136 Tw T* (\027\024\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036\027\017\016 \007\024\023\031\f\022\026\036\021\f\016 \024\022\ \026\026\027\017\036 )Tj 0.085 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \ \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\022\030\026\013\036\027\027\024\n \024\002\255\036\n\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026)Tj 0 Tw (-)Tj 0.419 Tw T* [(\r\017\f\017\n\024\f\021\017 \024\021 \024\023\036\030\026\021\017\r\027\ \024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\n\036\007\017\022\024-\021\026\022\021\017\004\036\f\022\024\005 )Tj 0.199 Tw T* (\024\002\f\021\026\027\024\r\022\017 [4,7]. \003\026\007\026\004\026 \024\ \022\026\026\027\017\016 \017\f\004\036\030\023\t\r\026\033\013\036\005\ )Tj 0.302 Tw T* (\023\024\n\024\013\017 \024\021\r\036\007\036\027\026 \220\021\026\023\026\ \n \f\023\036\006\017\026\035\017\017\030\024\r\026\027\027\024\005 \b\017\ )Tj 0 Tw (-)Tj 0.267 Tw T* [(\030\031\030\020\017\004\036\f\022\024\005 )0.5(\023\024\n\024\013\017 \(3, 4, )0.5(5 \211\204\215\), )0.5(\b\026\030\026\022\021\036\030\017\031\033)]TJ 0 Tw (-)Tj 0.363 Tw T* [(\013\017\n\f\016 )0.6(\r\t\f\024\022\024\005 )0.5(\024\f\027\026\013\036\027\027\024\f\021\034\033 )0.5(\007\017\026\020\027\024\f\021\017\004\036\f\022\017\n\017 )]TJ 0.184 Tw T* (\017\027\f\021\030\031\n\036\027\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \002\035\026\020\024\023\030\017\016\021\027\024\005\ \n\036\007\017\022\024-\021\026\022)Tj 0 Tw (-)Tj T* (\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\024\005 \ [4].)Tj 0.262 Tw T* (\206\026\027\020\030\036\027\026 \205\031\030\027\034\036 \(\206\205\))Tj /Span<>> BDC ( )Tj EMC (\227 \235\024\030\n\026 \027\036\022\030\024\021\017\017\030\031\033\013\ \036)Tj 0 Tw (-)Tj 0.236 Tw T* (\020\024 \235\026\f\006\017\017\021\026 \023\024\035\017\n\017\022\030\024\ \002\027\024\005 \220\021\017\024\035\024\020\017\017, \023\030\024\016\r\ \035\016\033)Tj 0 Tw (-)Tj 0.191 Tw T* (\013\026\016\f\016 \002\t\f\021\030\024 \023\030\024\020\030\036\f\f\017\ \030\031\033\013\036\005 \017\027\235\036\022\006\017\036\005 \021\022\026\ \027\036\005 )Tj 0.317 Tw T* [(\023\030\024\n\036\032\027\024\f\021\017, \020\036\027\017\021\026\035\017\ \005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\017\026\027\026\035\034\027\024\005 \024\002\035\026\f\021\017\ . )Tj 0.148 Tw T* (\232\026\013\036 \020\026\027\020\030\036\027\026 \n\024\001\024\027\022\ \017 \016\r\035\016\036\021\f\016 \r\021\024\030\017\004\027\024\005 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.175 Tw T* (\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\017\027\235\036\022\006\017\016\n \026\027\024\030\036\022\021\026\035\034\ \027\024\005 \024\027\t, \031\030\024\020\036)Tj 0 Tw (-)Tj 0.31 Tw T* [(\027\017\021\026\035\034\027\024\020\024 )0.6(\021\030\026\022\021\026, )0.5(\f\r\016\026\027\027\t\n )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 14.591 0 Td [(\n\036\f\021\027\024\005 )0.5(\021\030\026\r\n\024\005, )]TJ 0.334 Tw -14.591 -1.218 Td (\024\023\036\030\026\021\017\r\027\t\n\017 \r\n\036\001\026\021\036\035\034\ \f\021\r\026\n\017 \017\035\017 \026\002\024\035\036\r\026\027\017\016)Tj 0 Tw (-)Tj 0.23 Tw T* (\n\017 \n\024\004\036\r\t\r\024\007\016\013\017\b \023\031\021\036\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \024\021\007\ \036)Tj 0 Tw (-)Tj 0.216 Tw T* (\035\026 \032\036\035\031\007\024\004\027\024-\022\017\001\036\004\027\024\ \020\024 \021\030\026\022\021\026 [1,2]. \206\205 \016\r\035\016\036\021\ \f\016 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 707.7183 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 45.2263 698.791 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5646 56.0378 Tm (143)Tj ET endstream endobj 659 0 obj [675 0 R] endobj 660 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 247.8104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 247.8104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 210.6026 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 210.6026 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-142-148)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 82.1531 695.3259 Tm [(\235\t\025\013)10(\025)21(\237\026)11(\017\224\t\025\004 \220\n\005\002\005\013\n\225\004\016\r)10(\025\004 \020\004\225\004\t\n\004 \224\025\016)-10(\026\005\017\202\017\b\204\004\013)10(\025 )]TJ 0.688 -1.105 Td [(\016\022)-23.3(\025\013\t\004\016)-9.9(\026\005\004\020\200\t\217\024 \005\017\t\004\t\n\004\024 \b\t\004\255\005\ \206\204\n\t\t\025\013)10(\025 \025\026)11(\202\004\020\017 )]TJ 0.581 -1.105 Td [(\224\005\213\024\025\221 \r\n\204\r\n, \025\016)-10(\020\025\226\t\242\t\t\217\024 \013)10(\017\t\013\005\004\t\025\221 \210\002\005\t\200\004)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\240\016\004\020\004\b\n\225\022)-23.2(\033)124(.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 146.4413 633.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 157.7619 628.822 Tm [(, \001\017\024\025\220\n\t\022)-23.2(\036.\030.)]TJ 0 Tw 8.162 0 0 8.162 250.1408 633.484 Tm (2)Tj 0.023 Tw 14 0 0 14 254.7768 628.822 Tm [(, \f)-21(\020\n\024\025\b\022)-23.2(\034.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 337.1315 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 341.7674 628.822 Tm [(, \006\017\020\206\005\017\022)-23.2(\036.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 424.9065 633.484 Tm [(1,)-69(3)]TJ 0 Tc 0 Tw 14 0 0 14 436.2271 628.822 Tm (, )Tj -26.097 -1.143 Td [(\033)-21(\002\024\213\t\004\b\022)-23.2(\021.\007.)]TJ 8.162 0 0 8.162 152.587 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 157.223 612.822 Tm [(, \001\002\005\025\b\022)-23.2(\201.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 231.1081 617.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 598.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 595.1527 Tm [(\210\031\006\021\036)20(\227 \021\036 \253\021\025\004\t\t\025-\024\004\202\n\n\t\016\r\017\213\ \017\r\017\202\004\024\n\213 \n\024\004\t\n \001.\235.\022)-23.2(\037)19.9(\n\005\025\b\017\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\ \n\n \(\002\020.\022)-23.3(\f\r\017\202\004\024\n\r\017 )]TJ -0.331 -1.2 Td [(\035\004\255\004\202\004\b\017, \202.\022)-23.3(6\223, \013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)80(40)25(44, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 574.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 571.1527 Tm [(\210\031\037\227 \2531)112(602 \021\025\004\t\t\217\221 \r)-10(\020\n\t\n\225\004\016\r\n\221 \013)10.1(\025\016\224\n\026)11(\017\020\200\273 \235\n\t\025\255\025\005\025\t\217 \033\025\016\016\n\n\ \(\002\020.\022)-23.3(\201\017\225\t\017\213, \202.\022)-23.3(1)75(0, \033\025\016)-10(\026)11(\025\b\016\r\017\213 )]TJ -0.331 -1.2 Td [(\025\255\020\017\016)-10(\026\200, \013)62(.\022)-23.3(\033\025\016)-10(\026)11(\025\b-\t\017)-84(-)-52(\201\025\t\002)31.1(, 3)58(4406)34(4, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 550.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 547.1528 Tm [(\215\036)20(\227\021\036 \253\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)10.1(\016\r\n\221 \024\004\202\n\r)10(\025-\016\025\n\017\020\200\t\217\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026\273 \(\224\005-)-41.9(\026 \037)31(\025\t\202\005\017\026\200\004\b\016\r\n\221, \202.\022)-23.3(7)58(2, \020\n\026)11(\004\005 \f)-52(, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)46(5)35(2)46(7)127(1)69(, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.036 Tw 9 0 0 9 119.0551 516.6489 Tm (\037\036\035\034: \033\032\031\030\027\026\031\025\024\023\032\022\032\031\ \021\020\023\017 \n\f\022\025\022\007\027\024\n\031\027 \025\020\240\f\005\ \030\027\025\022\027 \030\022\020\b\025\031\024\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\t \021\025\027\240\032\005\213\022\025\025\031\b\031\ \032\020\025\027\025\022\t \033\032\t)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\026\031\235 \n\022\213\n\022, \031\024\f\031\255\025\027\025\025\031\b\031\ \b\020\025\b\032\027\025\031\235 \214\r\032\025\017\027, \021)Tj /Span<>> BDC ( )Tj EMC (\032\020\026\n\020\200 \026\025\031\b\031\204\023\020\033\025\031\b\031 \ \200\022\032\r\032\b\022\007\027\024\n\031\b\031 \f\027\007\027\025\022\t\ .)Tj 0.062 Tw 0 -1.111 TD (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \033\020\006\022\027\025\023 \225. \033\031\f\r\007\ \022\f \031\024\n\031\f\031\007\025\031\027 \032\020\025\027\025\022\027\ \033\032\031\026\027\255\025\031\024\023\022 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\024\023\032\r\n\023\022\021\025\013\026 \021\025\027\240\ \032\005)Tj 0 Tw (-)Tj 0.02 Tw 0 -1.111 TD (\213\022\025\025\013\026 \033\031\021\032\027\255\030\027\025\022\027\026\ \024\032\027\030\025\027\020\026\033\r\f\t\032\025\031\b\031 \031\023\030\ \027\f\020 \033\032\t\026\031\235 \n\022\213\n\022. \001\020)Tj /Span<>> BDC ( )Tj EMC (2 \r\032\031\021\025\027 \031\n\020\016\020\025\022\t \026\027\030\022\006\ \022\025\024\n\031\235 \033\031\026\031)Tj 0 Tw (-)Tj 0.159 Tw T* (\212\022 \021\013\033\031\f\025\027\025\031 \031\033\027\032\020\023\022\ \021\025\031\027 \f\027\007\027\025\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\236\027\026\027: \203\031\032\026\022\032\031\021\020\025\022\027\ \n\031\025\006\027\021\031\235 \024\022\b\026\031\024\023\031\026\013, \ \r\213\022\021\020\025\022\027 \030\027\203\027\n\023\020 )Tj 0.055 Tw T* (\033\032\t\026\031\235 \n\022\213\n\022, \240\022\f\020\023\027\032\020\f\ \017\025\031\027 \033\020\032\020\032\027\n\023\020\f\017\025\031\027 \030\ \032\027\025\022\032\031\021\020\025\022\027. \205\033\r\024\023\t 3 \024\ \r\023\031\n \033\031\024\f\027 \031\033\027\032\020\006\022\022 \025\020\ )Tj /Span<>> BDC ( )Tj EMC (4 \r\032\031\021\025\027 )Tj 0.053 Tw T* (\031\n\020\016\020\025\022\t \026\027\030\022\006\022\025\024\n\031\235 \ \033\031\026\031\212\022 \021\013\033\031\f\025\027\025\031 \031\033\027\ \032\020\023\022\021\025\031\027 \021\026\027\213\020\023\027\f\017\024\023\ \021\031 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r \032\020\016\021\022\021\213\027\b\031\024\t \031\ \024\f\031\255\025\027)Tj 0 Tw (-)Tj 0.023 Tw T* (\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 \b\020\025\b\032\027\025\013 \214\r\032\025\017\027. \001\020)Tj /Span<>> BDC ( )Tj EMC (14-\027 \024\r\023\022 \033\020\006\022\027\025\023 \021\013\033\022\024\ \020\025 \025\020)Tj /Span<>> BDC ( )Tj EMC (\020\026\240\r\f\020\023\031\032\025\031\027 \f\027\007\027\025\022\027.\ )Tj 0.103 Tw T* (\206\036\207\210\035\034\003\201: \031\033\022\024\020\025\025\013\235\ \n\f\022\025\022\007\027\024\n\022\235 \024\f\r\007\020\235 \033\031\n\020\ \016\020\f, \007\023\031 \203\031\032\026\022\032\031\021\020\025\022\027\ \n\031\025\006\027\021\031\235 \024\022\b\026\031\024\023\031\026\013 \033\ \032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027)Tj 0 Tw (-)Tj 0.251 Tw T* (\024\023\032\r\n\023\022\021\025\031\026 \021\025\027\240\032\005\213\022\ \025\025\031\026 \032\020\025\027\025\022\022 \033\032\t\026\031\235 \n\022\ \213\n\022 \024\023\020\f\031 \033\032\022\007\022\025\031\235 \031\023\n\ \020\016\020 \031\023 \021\013\033\031\f\025\027\025\022\t \021\020\255\025\ \031\b\031 )Tj -0.019 Tw T* (\204\f\027\026\027\025\023\020 4D-\n\031\025\006\027\033\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 \020\025\023\027\b\032\020\030\025\031\b\031 \030\022\024\023\020\f\ \017\025\031\b\031 \031\023\026\013\021\020\025\022\t. \020\n\022\026 \031\ \240\032\020\016\031\026, \025\027\024\020\025\022\032\031\021\020\025\025\ \013\235 \031\023\n\f\005)Tj 0 Tw (-)Tj 0.179 Tw 0 -1.111 TD (\007\027\025\025\013\235 \r\007\020\024\023\031\n \033\032\t\026\031\235\ \n\022\213\n\022, \021\027\032\031\t\023\025\027\027 \021\024\027\b\031\ , \t\021\022\f\024\t \022\024\023\031\007\025\022\n\031\026 \032\020\016\ \021\022\023\022\t \b\032\031\016\025\031\b\031 \031\024\f\031\255\025\027\ \025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.11 Tw 0 -1.111 TD [(\b\020\025\b\032\027\025\013 \214\r\032\025\017\027. )0.5(\202\032\031\026\027 \023\031\b\031, \r\213\022\021\020\025\022\027 )0.5(\030\027\203\027\n\023\020 \024\023\027\025\n\022 \033\032\t\026\031\235\ )0.5(\n\022\213\n\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\030\020\025\025\031\026 \n\f\022\025\022\007\027\024\n\031\026 \024\f\r\ \007\020\027 \025\027 )Tj -0.023 Tw T* (\t\021\f\t\f\031\024\017 \033\032\022\031\032\022\023\027\023\025\013\026\ \204\f\027\026\027\025\023\031\026 4D-\n\031\025\006\027\033\006\022\022\ , \020)Tj /Span<>> BDC ( )Tj EMC (\032\r\023\022\025\025\031\027 \021\013\033\031\f\025\027\025\022\027 \033\ \020\032\020\032\027\n\023\020\f\017\025\031\b\031 \030\032\027\025\022\032\ \031\021\020\025\022\t )Tj 0.023 Tw T* (\025\027 \031\n\020\016\020\f\031 \016\025\020\007\022\023\027\f\017\025\ \031\b\031 \021\f\022\t\025\022\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\203\022\f\020\n\023\022\n\r \032\020\016\021\022\023\022\t \ \022\025\203\027\n\006\022\031\025\025\013\200 \031\024\f\031\255\025\027\ \025\022\235.)Tj 0.039 Tw T* (\207\003\202\035\224\232\036\001\002\036: \021\025\027\240\032\005\213\022\ \025\025\013\027 \032\020\025\027\025\022\t \033\032\t\026\031\235 \n\022\ \213\n\022 \024\031\033\032\t\255\027\025\013 \024)Tj /Span<>> BDC ( )Tj EMC (\021\013\024\031\n\022\026 \032\022\024\n\031\026 \032\020\016\021\022\023\ \022\t \255\022\016\025\027\r\b\032\031\255\020)Tj 0 Tw (-)Tj 0.028 Tw T* (\005\212\022\200 \031\024\f\031\255\025\027\025\022\235. \225\022\032\r\032\ \b\022\007\027\024\n\031\027 \f\027\007\027\025\022\027 \030\020\025\025\ \031\235 \n\020\023\027\b\031\032\022\022 \033\031\024\023\032\020\030\020\ \021\213\022\200 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \204\023\020\033\020\200 \026\027\030\ \022\006\022\025)Tj 0 Tw (-)Tj 0.053 Tw T* (\024\n\031\235 \204\021\020\n\r\020\006\022\022 \030\031\f\255\025\031 \031\ \024\025\031\021\013\021\020\023\017\024\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\024\031\025\022\203\022\006\022\032\031\021\020\025\025\031\ \026 \033\031\030\200\031\030\027, \n\020\n \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \200\020\032\020\n\ \023\027\032\020 )Tj -0.009 Tw T* (\032\020\025\027\025\022\t, \024\031\024\023\031\t\025\022\t \033\020\006\ \022\027\025\023\020, \031\033\013\023\020 \026\027\030\022\006\022\025\024\ \n\031\b\031 \033\027\032\024\031\025\020\f\020, \023\020\n \022)Tj /Span<>> BDC ( )Tj EMC (\031\023 \026\027\030\022\n\031-\023\020\n\023\022\007\027\024\n\031\235\ \031\240\024\023\020\025\031\021\n\022. )Tj 0.052 Tw T* (\001\027\024\026\031\023\032\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\255\025\031\024\023\022 \031\240\027\024\033\027\007\027\025\022\ \t \033\032\027\027\026\024\023\021\027\025\025\031\024\023\022 \026\027\ \255\030\r \204\023\020\033\020\026\022 \026\027\030\022\006\022\025\024\ \n\031\235 \204\021\020\n\r\020\006\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\024\022\024\023\027\026\027 )Tj 0.257 Tw 0 -1.111 TD (\026\025\031\b\031\204\023\020\033\025\031\b\031 \200\022\032\r\032\b\022\ \007\027\024\n\031\b\031 \f\027\007\027\025\022\t, \024\021\031\027\021\032\ \027\026\027\025\025\020\t \030\022\020\b\025\031\024\023\022\n\020 \022\ )Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\027 \031\024\f\031\255\025\027\025\022\235 \033\031\ \016\021\031\f\t\005\023 )Tj 0.023 Tw 0 -1.111 TD (\026\022\025\022\026\022\016\022\032\031\021\020\023\017 \033\031\024\f\027\ \030\024\023\021\022\t \240\031\027\021\031\235 \200\022\032\r\032\b\022\ \007\027\024\n\031\235 \023\032\020\021\026\013.)Tj /T1_2 1 Tf 0.01 Tc 0.079 Tw 8 0 0 8 70.9061 291.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.084 Tw 8.554 0 Td ( \b\020\025\b\032\027\025\020 \214\r\032\025\017\027; \025\027\n\032\031\ \023\022\016\022\032\r\005\212\020\t \022\025\203\027\n\006\022\t \026\t\ \b\n\022\200 \023\n\020\025\027\235; \021\025\027\240\032\005\213\022\025\ \025\013\027 \033\031\021\032\027\255\030\027\025\022\t \033\032\t\026\031\ \235 \n\022\213\n\022; \031\b\025\027)Tj 0 Tw (-)Tj 0.023 Tw -8.559 -1.2 Td (\024\023\032\027\f\017\025\031\027 \032\020\025\027\025\022\027; \026\025\ \031\b\031\204\023\020\033\025\031\027 \200\022\032\r\032\b\022\007\027\024\ \n\031\027 \f\027\007\027\025\022\027)Tj /T1_2 1 Tf 0.01 Tc 0.015 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.02 Tw 10.398 0 Td ( \020\021\023\031\032\013 \030\027\n\f\020\032\022\032\r\005\023 \031\023\ \024\r\023\024\023\021\022\027 \t\021\025\013\200 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\023\027\025\006\022\020\f\017\025\013\200 \n\031\025\203\f\022\n\ \023\031\021 \022\025\023\027\032\027\024\031\021, \024\021\t\016\020\025\ \025\013\200 \024)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\027\235 )Tj 0.023 Tw -10.403 -1.2 Td (\025\020\024\023\031\t\212\027\235 \024\023\020\023\017\022)Tj /T1_2 1 Tf 0.033 Tc 0.016 Tw 0.005 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.021 Tw 9.189 0 Td ( \213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \222\026\n\024\b\017\027)Tj /Span<>> BDC ( )Tj EMC (\210.\230., \202\035\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\202., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \222\031\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202. \204\027\024\020\024\220\021\026\023\027\024\036 \b\017\030\031\ \030\020\017\004\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.036 Tw -9.194 -1.2 Td (\f\022\024\036 \035\036\004\036\027\017\036 \023\024\f\021\030\026\007\026\ \r\001\036\020\024 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\020\027\036\f\021\030\036\035\034\027\t\n \030\026\027\036\027\017\036\ \n \r\027\036\002\030\033\001\017\027\027\024\020\024 \024\021\007\036\035\ \026 \023\030\016\n\024\005 \022\017\001\022\017, \024\f\035\024\032\027\ \201\027\027\t\n \020\026\027\020\030\036\027\024\005 \205\031\030\027\034\ \036.)23.1( )]TJ /T1_0 1 Tf -0.023 Tw 0 -1.2 TD (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (142\226148. https://doi.org/10.33878/2073-7556-2026-25-1-142-148)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 138.3163 184.4333 Tm [(Multistage sur)31(gical tr)31(eatment of\022)-23.2(a\022)-23.3(victim with )]TJ -1.218 -1.167 Td [(a\022)-23.3(gunsh)11(ot w)10.9(ound of\022)-23.3(th)11(e e)21(xtr)21.1(aperitoneal par)-20(t of\022)-23.3(th)11(e )]TJ 1.469 -1.167 Td [(r)31(ectum complicated b)10(y F)15(ournier\236)63.1(s gangr)31(ene)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 117.9294 Tm [(Roman\022)-23.3(V)62(.\022)-23.2(Esele)11(vich)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 178.589 122.5914 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 189.9096 117.9294 Tm [(, Oleg\022)-23.2(I.\022)-23.3(Samokhin)]TJ 0 Tw 8.162 0 0 8.162 295.4661 122.5914 Tm (2)Tj 0.023 Tw 14 0 0 14 300.1021 117.9294 Tm [(, P)20(av)12(el\022)-23.3(A)-30.9(.\022)-23.3(Alimov)]TJ 0 Tw 8.162 0 0 8.162 397.2309 122.5914 Tm (1)Tj 0.023 Tw 14 0 0 14 401.8669 117.9294 Tm [(, Oleg\022)-23.2(V)62(.\022)-23.3(Balur)21(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 492.9476 122.5914 Tm [(1,)-69(3)]TJ 0 Tc 0 Tw 14 0 0 14 504.2682 117.9294 Tm (, )Tj -30.957 -1.143 Td [(V)31(aler)-31(y\022)-23.2(N.\022)-23.3(Rum)21(y)21(antse)11(v)]TJ 8.162 0 0 8.162 194.8286 106.5914 Tm (1)Tj 0.023 Tw 14 0 0 14 199.4646 101.9294 Tm [(, Dmitrii\022)-23.2(A)-31(.\022)-23.3(Sur)20(ov)]TJ 0 Tw 8.162 0 0 8.162 296.1168 106.5914 Tm (1)Tj 5.83 0 0 5.83 70.8661 87.5901 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 84.2601 Tm [(S.M.\022)-23.3(Kir)20(ov Militar)-30.9(y Medical Academ)21(y \(Akademika Lebede)11(v)10(a\022)-23.2(st., 6J, Saint P)10(eter)20(sbur)31(g, 1)138(9)79.9(40)25.1(44, Russia\))]TJ 0 Tw ( )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 525.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 516.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8528 56.0378 Tm (142)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 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Eur)-32(opean S)-16(o)-16(c)-24(ie)-12(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(Col)30(op)25(r)-32(o)-16(c)-16(t)17(ol)30.1(o)-16(g)16(y Cor)-23.9(e )]TJ -0.034 Tw -1.296 -1.25 Td [(Outcome se)-12(t for haemor)-23.9(r)-24(hoid)42(al disease: an)]TJ /Span<>> BDC ( )Tj EMC [(inter)-14.9(na)15(t)-32(ional Delphi stud)17(y )]TJ 0.081 Tw T* [(among heal)56(t)-13(hcar)-24(e p)25(r)-32(ofessionals. )]TJ /T1_4 1 Tf 13.475 0 Td (Colorectal Dis)Tj /T1_3 1 Tf (. 2019;21\(5\):570\22680. )Tj 0 Tw -13.475 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.14553)Tj 0 0 0 1 k /GS1 gs -0.015 Tw -1.847 -1.25 Td (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bl)-16(a)-17(ck)]TJ /Span<>> BDC ( )Tj EMC [(N. P)40(a)15(t)-32(ient r)-24(epor)-22(ted outcome measur)-24(es could help tr)-33(ansfor)-15.9(m )]TJ 0 Tw -1.296 -1.25 Td [(heal)56(t)-13(hcar)-23.9(e. )]TJ /T1_4 1 Tf 4.794 0 Td (BMJ)Tj /T1_3 1 Tf 0.023 Tw [(. 2013;346:f167. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1136/bmj.f167)Tj 0 0 0 1 k /GS1 gs 0.161 Tw -4.794 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(uiper)]TJ /Span<>> BDC ( )Tj EMC (SZ, Kimman)Tj /Span<>> BDC ( )Tj EMC [(ML, V)25(an T)45(ol)]TJ /Span<>> BDC ( )Tj EMC [(RR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)40(a)15(t)-32(ient r)-24(epor)-22(ted out)]TJ 0 Tw (-)Tj 0.071 Tw -1.296 -1.25 Td [(come measur)-24(e-haemor)-23.9(r)-24(hoid)42(al im)10.1(p)32(a)-17(c)-16(t and sa)15(t)-32(isf)16(a)-17(c)-16(t)-32(ion scor)-24(e \(PROM-)]TJ 0.001 Tw T* [(HIS)17(S\): devel)30.1(opment, r)-24(el)-31(iabil)-30.9(i)-24(t)-10(y and constr)-22(uc)-16(t )0.5(v)-15(al)-31(idi)-24(t)-10(y. )]TJ /T1_4 1 Tf [(Colorectal )0.5(Dis. )]TJ /T1_3 1 Tf 0.023 Tw 29.055 20 Td [(2022;24:992\2269. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16079)Tj 0 0 0 1 k /GS1 gs 0.223 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)40(er)-38(wee)]TJ /Span<>> BDC ( )Tj EMC [(CB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Q)-15.9(ual)-31(i)-24(t)-10(y cr)-37(i)-24(ter)-37(ia wer)-24(e p)25(r)-32(oposed for measur)-24(e)]TJ 0 Tw (-)Tj 0.181 Tw -1.296 -1.25 Td [(ment p)25(r)-32(oper)-21.9(t)-32(ies of)]TJ /Span<>> BDC ( )Tj EMC [(heal)56(t)-13(h st)15.1(a)14.9(tus quest)-32(ionnair)-23.9(es. )]TJ /T1_4 1 Tf (J Clin Epidemiol.)Tj /T1_3 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2007;60\(1\):34\22642. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1016/j.jcl)-30.9(inepi.2006.03.012)]TJ 0 0 0 1 k /GS1 gs 0.196 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)25(uiper)]TJ /Span<>> BDC ( )Tj EMC [(SZ, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al., Engl)-31(ish tr)-33(ansl)-15.9(a)15(t)-32(ion and cr)-32(oss-cul)56(tur)-32.9(al v)-15(al)-30.9(id)42(a)]TJ 0 Tw (-)Tj 0.159 Tw -1.296 -1.25 Td [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he p)32(a)15(t)-32(ient-r)-24(epor)-22(ted outcome measur)-23.9(ement-haemor)-24(r)-23.9(hoid)42(al )]TJ 0.006 Tc 0.349 Tw T* [(im)10.1(p)32.1(a)-16.9(c)-15.9(t and sa)15.1(t)-31.9(isf)16(a)-16.8(c)-16(t)-31.9(ion scor)-23.9(e \(PROM-HIS)17.1(S\). )]TJ /T1_4 1 Tf [(Colorectal Disease.)6( )]TJ /T1_3 1 Tf 0 Tc 0.023 Tw T* [(2023;25:1671\2261678. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.16650)Tj 0 0 0 1 k /GS1 gs 0.118 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(ild)]TJ /Span<>> BDC ( )Tj EMC [(D, G)20(r)-32(ove)]TJ /Span<>> BDC ( )Tj EMC [(A, Mar)-22(t)-32(in)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-37(inc)-24(iples of)]TJ /Span<>> BDC ( )Tj EMC [(go)-16(od p)25(r)-33(a)-17(c)-15.9(t)-32(ice for )]TJ 0.052 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 1.635 0 Td [(tr)-33(ansl)-15.9(a)15(t)-32(ion )0.5(and )0.6(cul)56(tur)-32.9(al )0.5(ad)42(apt)15(a)15(t)-32(ion )0.6(p)25(r)-32(o)-16(cess )0.6(for )0.5(p)32(a)15(t)-32(ient-r)-23.9(epor)-22(ted )]TJ 0.069 Tw -1.635 -1.25 Td [(outcomes \(PRO\) measur)-23.9(es: r)-24(epor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ISPOR t)15(ask for)-31.9(ce for tr)-33(ans)]TJ 0 Tw (-)Tj 0.316 Tw T* [(l)-16(a)15(t)-32(ion and cul)56.1(tur)-33(al ad)42(apt)15(a)15(t)-32(ion. )]TJ /T1_4 1 Tf [(V)33(alue Health.)]TJ /T1_3 1 Tf ( 2005;8\(2\):94\226104. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/j.1524-4733.2005.04054.x)Tj 0 0 0 1 k /GS1 gs 0.013 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(M)-24(ohamad A)15(d)42(am)]TJ /Span<>> BDC ( )Tj EMC (B, Hon)Tj /Span<>> BDC ( )Tj EMC [(YK, L)35(ee)]TJ /Span<>> BDC ( )Tj EMC (KY. A)Tj /Span<>> BDC ( )Tj EMC [(step-b)12.1(y-step guide t)17(o)]TJ /Span<>> BDC ( )Tj EMC (ques)Tj 0 Tw (-)Tj 0.08 Tw -1.796 -1.25 Td [(t)-32(ionnair)-23.9(e v)-15(al)-31(id)42(a)15(t)-32(ion r)-23.9(esear)-32(ch. K)25(ual)-15.9(a L)35(um)10(pur, Mal)-16(a)15(y)-12.9(sia: Inst)-32(i)-24(tute for )]TJ 0.023 Tw T* [(Cl)-31(inical R)13(esear)-32(ch. )]TJ /T1_4 1 Tf (NIH MY.)Tj /T1_3 1 Tf [( 2022. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.5281/zenod)-15.9(o.6801209)]TJ /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.7397 56.0378 Tm (141)Tj ET endstream endobj 658 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   r!1"AQ#2TaqBRS3Uc$4rs %&'()*56789:CDEFGHIJVWXYZbdefghijtuvwxyz?jEQEQEQEQEQEQEQEQEQEQEQEQEQEQ@j^71N.v88PMp֗W:vHPD(nN0G#.D+FLs*SSYݮ-,KIs6~P#Z_í*·U@INLt`yp+AƼ2S/|Y@=le1H@ 1@FEGqFq[\yp'49!OA8Qql|5 ȂFac[Rʹ A\ӈElSFUR<=]ZGln+3H$FSa; ֶYw&oM 4>##:͆i"ܡ\(8#;;bɣxyk*rHfxe#Y  Ij7YcYRApk]l Kaۡ HStXÇ%KQ#BvJ YX rAk'w!J* !* ~\xo0PBJr dyGjCNuhNlK#͵a;GXQ'~\xI$,Xb+s6Ap1BsgN*˛R3ߝ^_!)x;@y]:=x7ႆA{X8Ll^^,crB0(0|{tC1Ls,ѕY"F ! uuΛ46kr%^oo4su{ %*bKI$ ;WC2@ =pk]o&12s6HPv%TҼcY([nB C |> )J)܌#ls=3^.\7g7-f6=S㷞>Z $2p+p`QDUI,r h%H+9Bߡ=kSIDg/&paے'[_zeE,IcIQ8+x74|JJ( yɭdN4FGpDs7'`פWQ-⩁Qd%C;6zیi^`/7'7NN93f!;RxEt8#* 5s:=U.{c)&=pC.ާ~?pCqrc{qA$o<Gn/%ZUo[b!dH0p3NTہD8/=8ˆ7F" ,ydL^NTRv7ֺwO͂ep0jA[ I<&7* t7q'Gk.؃qb.02OJ.ViD8Z;t##;dT Ktk6#dro/cY5m0cYqq>Fvi xJ .R3,#}=W'xDЉpZ4=͟7JtSmkqkwډ&z8J[[ɘ-ÄMrxod2#*ox9{UdeDF=0Q'YZֱ"(F[ fN+ia7R+q4r%Vq$nan "m=G%gNnNJYb(oD)^CaֽB6Ϩl&X"Uf ;ne.7*'i{/{5V `q"̡d9G1Va9`kYԧ7Z#wxѻ״/0I%̍om4Gnʍ&#r$nM\PVq,I b@cw2 铎q\#k9oJ,jY] yKSVؐF[qDU-gMC' Gh KD##NݍE8c|*j#ڻCjR\xƯFF>iOzm23A(Np;Jb:GP]C䟁-g#V9Q|s̯G »#de/: ?#Ea>d7QHFA*!=<'ü52ܴlC6G߹9kHZ#@R $0u8=Q]O )]G,{=YWyr-feĞ*".tp܅H r$eC8cֵga ܬƼiy8u< !ɢR 低0 s8NOJmq׍0]g"_Wusgp$ݹ7F[+ҤA|qy8q!FI׶GڥJ<3qe&ܧb+bIc&PU&@svG[n/^! 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\r\n\036\001\026\021\036\ \035\034\f\021\r\024 )Tj -0.008 Tw 0 -1.218 TD [(\f\024\024\021\r\036\021\f\021\r\031\036\021 )0.6(\024\032\017\007\026\027\017\016\n )0.6(\023\026\006\017\036\027\021\026 )0.5(\017, )0.5(\021\026\022\017\n )0.6(\024\002\030\026\024\n, )]TJ 0.005 Tw T* (\027\026\f\022\024\035\034\022\024 \024\027 \031\007\024\r\035\036\021\r\ \024\030\036\027 \021\036\n \017\035\017 \017\027\t\n \b\017\030\031\030\ \020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\n \r\n\036\001\026\021\036\035\034\f\021\r\024\n.)Tj -0.012 Tw T* [(\210\030\017\020\017\027\026\035\034\027\t\005 )0.5(\020\024\035\035\026\027\007\f\022\017\005 \024\023\030\024\f\027\017\022\ PROM-HIS)17.1(S \031\032\036 )]TJ 0.14 Tw T* (\002\t\035 \023\030\024\021\036\f\021\017\030\024\r\026\027 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \036\020\024 \023\f\017\b\024\n\036\ \021\030\017\004\036)Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\f\022\017\b \b\026\030\026\022\021\036\030\017\f\021\017\022 \(\f\021\030\ \031\022\021\031\030\027\t\036 \f\r\024\005\f\021\r\026, \027\026\007\036\ \032)Tj 0 Tw (-)Tj 0.15 Tw 0 -1.218 TD (\027\024\f\021\034, \022\024\027\f\021\030\031\022\021\017\r\027\026\016\ \r\026\035\017\007\027\024\f\021\034\), \004\021\024 \027\036\024\002\b\ \024\007\017\n\024 )Tj 0.196 Tw T* (\007\035\016 \021\026\022\024\020\024 \030\024\007\026 \024\023\030\024\f\ \027\017\022\024\r, \023\030\036\007\027\026\027\026\004\036\027\027\t\b\ \007\035\016 )Tj 0.175 Tw T* (\017\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \f\022\030\t\021\t\b \023\036\030\036\n\036\027\ \027\t\b, \021\026\022\017\b \022\026\022 )Tj -0.015 Tw T* (\022\026\004\036\f\021\r\024 \032\017\027\017 \(\r\024\023\030\024\f \212\ 2\) \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\034 \035\036)Tj 0 Tw (-)Tj 0.085 Tw T* (\004\036\027\017\036\n \(\r\024\023\030\024\f \2123\). \211\004\017\021\t\ \r\026\016 \220\021\024\021 \235\026\022\021, \027\026\n\017 \024\032\017\ )Tj 0 Tw (-)Tj 0.058 Tw 0 -1.218 TD (\007\026\035\024\f\034, \004\021\024 \030\031\f\f\022\024\016\t\004\027\ \026\016 \r\036\030\f\017\016 \024\023\030\024\f\027\017\022\026 \f\022\024\ \030\036\036 )Tj 0.264 Tw 0 -1.218 TD (\r\f\036\020\024 \002\031\007\036\021 \017\007\036\027\021\017\004\027\024\ \005 \024\030\017\020\017\027\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\035\034 \032\036 )Tj 0.134 Tw 0 -1.218 TD (\023\024\027\016\021\027\024\005 \007\035\016 \030\024\f\f\017\005\f\022\ \024\020\024 \023\026\006\017\036\027\021\026. \210\007\027\026\022\024 \ \220\021\024 \027\036 )Tj 0.048 Tw T* (\r\f\036\020\007\026 \021\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\031\033 \024\004\036\030\036\007\034, \r\r\017\007\031 \021\ \024\020\024, \004\021\024 \021\026\030\020\036\021)Tj 0 Tw (-)Tj 0.008 Tw T* (\027\t\005 \016\t\022 \n\024\032\036\021 \023\030\017\r\027\024\f\017\021\ \034 \024\023\030\036\007\036\035\036\027\027\t\036 \022\024\027\021\036\ \022\f\021)Tj 0 Tw (-)Tj 0.09 Tw T* [(\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.757 0 Td [(\f\036\n\026\027\021\017\004\036\f\022\017\036 )0.5(\030\026\035\017\004\017\016, \027\036 )0.5(\f\024\024\021\r\036\021\f\021\r\031\033\013\017\036 )]TJ 0.107 Tw -2.757 -1.218 Td [(\f\n\t\f\035\031 \017/\017\035\017 )0.5(\f\021\030\031\022\021\031\030\036 )0.5(\024\030\017\020\017\027\026\035\026. \200)]TJ /Span<>> BDC ( )Tj EMC 16.332 0 Td (\027\026\001\036\n \f\035\031\004\026\036 )Tj 0.047 Tw -16.332 -1.218 Td [(\017\n\036\027\027\024 )0.5(\220\021\024 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.758 0 Td [(\f\035\031\004\017\035\024\f\034, )0.6(\004\021\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.044 0 Td [(\017\021\024\020\036 )0.5(\023\030\017\r\036\035\024 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 6.971 0 Td (\027\036\024\002)Tj 0 Tw (-)Tj 0.161 Tw -19.774 -1.218 Td (\b\024\007\017\n\024\f\021\017 \024\021\024\005\021\017 \024\021 \007\024\ \f\035\024\r\027\024\020\024 \023\036\030\036\r\024\007\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.452 Tw T* (\r\027\036\f\021\017 \027\036\022\024\021\024\030\t\036 \007\024\023\024\ \035\027\036\027\017\016/\026\022\006\036\027\021\t, \007\035\016 \031\f\ \017)Tj 0 Tw (-)Tj 0.201 Tw T* [(\035\036\027\017\016 )0.5(\r\026\032\027\024\f\021\017 \017\027\235\024\030\n\026\006\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\017\r\035\036\004\036\027\017\016 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC (\027\036\005 )Tj 0.182 Tw T* (\r\027\017\n\026\027\017\016 \023\026\006\017\036\027\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\n \f\035\031\004\026\036 \n\t \002\t\035\017 \r\t)Tj 0 Tw (-)Tj 0.104 Tw T* (\027\031\032\007\036\027\t \024\021\024\005\021\017 \024\021 \007\024\f\035\ \024\r\027\024\020\024 \023\036\030\036\r\024\007\026 \023\030\036\007\035\ \024\032\036)Tj 0 Tw (-)Tj 0.159 Tw T* (\027\017\005, \031\022\026\t\r\026\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\034 \r\024\027\017\022\027\024\r\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.153 Tw T* (\035\017\004\017\016 \f\017\n\023\021\024\n\024\r, \021\026\022 \022\026\ \022 \r)Tj /Span<>> BDC ( )Tj EMC (\022\031\035\034\021\031\030\036 \027\026\001\036\005 \f\021\030\026\027\ \t )Tj 0.096 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\017\b\024\007\036 \030\036\007\022\024 \017\f\023\024\035\034\031\ \036\021\f\016 \f\035\024\r\024 \253\026\027\031\f\273, \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\013\036 )Tj -0.027 Tw T* (\007\035\016 \031\022\026\026\027\017\016 \035\024\022\026\035\017\026\ \006\017\017, \027\026\023\030\017\n\036\030, \002\024\035\017, \023\026\ \006\017\036\027\021\t )Tj -0.021 Tw T* (\017\f\023\024\035\034\031\033\021 \024\023\030\036\007\036\035\036\027\ \017\036 \253\024\002\035\026\f\021\034 \026\007\027\036\020\024 \023\030\ \024\b\024\007\026\273. )Tj 0.098 Tw T* (\212\030\031\020\017\n \023\030\017\n\036\030\024\n \016\r\035\016\036\021\ \f\016 \026\n\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\024\005 )Tj 0.165 Tw T* [(\r\036\030\f\017\017 \024\023\030\024\f\027\017\022\026 \020\035\026\020\ \024\035\026 )0.5(\253\n\036\001\026\021\034\273 \027\026)]TJ /Span<>> BDC ( )Tj EMC 17.338 0 Td [(\020\035\026\020\024\035 )0.5(\253\026)]TJ 0 Tw (-)Tj 0.005 Tw -17.338 -1.218 Td (\021\030\031\007\027\016\021\034\273, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \024\023\017\f\026\027\017\016 \r\035\017\016\027\ \017\016 \f\017\n\023\021\024\n\024\r )Tj 0.157 Tw T* (\020\036\n\024\030\030\024\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \032\017\027\034 \023\026\006\ \017\036\027\021\026, \021\024\004\027\036\036 )Tj 0.019 Tw T* (\024\021\030\026\032\026\036\021 \f\n\t\f\035 \021\024\020\024, \024)Tj /Span<>> BDC ( )Tj EMC (\004\036\n \f\023\030\026\001\017\r\026\036\021\f\016. \200\024 \r\021\024\ \030\024\n )Tj 0.009 Tw T* (\f\035\031\004\026\036, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \022\024\020\027\017\021\017\r\027\ \024\020\024 \007\036\002\030\017\235\017\027\020\026 \023\026)Tj 0 Tw (-)Tj 0.144 Tw T* (\006\017\036\027\021\024\r \n\t \023\024\027\016\035\017, \004\021\024 \027\ \036\024\002\b\024\007\017\n\024 \r\t\007\036\035\036\027\017\036 \021\036\ \b )Tj 0.15 Tw T* [(\004\026\f\021\036\005 )0.5(\021\036\022\f\021\026, \022\024\021\024\030\t\036 \031\022\026\t\r\026\ \033\021 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\020\024\030\017\024\027\021 )0.5(\r\030\036)]TJ 0 Tw (-)Tj 0.023 Tw T* (\n\036\027\017, \026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\005 \023\026\006\017\036\027\021\031 \023\030\036\ \007\035\026\020\026\036\021\f\016 \007\026\021\034 \024\006\036\027\022\ \031 )Tj 0.104 Tw T* [(\021\016\032\036\f\021\017 )0.6(\f\017\n\023\021\024\n\024\r )0.5(\020\036\n\024\030\030\024\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.512 0 Td [(\017\b )0.5(\r\035\017\016\027\017\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.385 0 Td (\022\026\004\036)Tj 0 Tw (-)Tj 0.019 Tw -19.897 -1.218 Td (\f\021\r\024 \032\017\027\017. \233\021\024 \032\036 \022\026\f\026\036\ \021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\026 \2123, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.121 Tw T* (\f\023\030\026\001\017\r\026\036\021\f\016 \024\002 \031\007\024\r\035\036\ \021\r\024\030\036\027\027\024\f\021\017 \b\017\030\031\030\020\017\004\036\ \f\022\017\n )Tj 0.095 Tw T* (\035\036\004\036\027\017\036\n, \023\030\024\r\036\007\036\027\027\t\n \r\ )Tj /Span<>> BDC ( )Tj EMC (\002\035\017\032\026\005\001\031\033 \022)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\036 \017\027\021\036\030)Tj 0 Tw (-)Tj 0.189 Tw T* (\r\034\033\017\030\024\r\026\027\017\016 \027\036\007\036\035\033. \200\026\ \032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \r\027\036\f\036\ \027)Tj 0 Tw (-)Tj 0.183 Tw T* (\027\t\036 \027\026\n\017 \017\n\036\027\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\022\f\021 \024\023\030\024\f\027\017\022\026, \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj 0.009 Tw T* (\f\022\026\026\027\024 \030\026\027\036\036, \027\036 \023\030\017\r\036\ \035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\036\027\017\033 \022\024\027\f\021\030\031\022\006\017\017\ )Tj 0.103 Tw T* (\007\024\n\036\027\024\r \017, \004\021\024 \f\026\n\024\036 \020\035\026\ \r\027\024\036, \026\035\024\032\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017)Tj 0 Tw (-)Tj T* (\027\026\035\034\027\024\n \024\023\030\024\f\027\017\022\036 \f\n\t\f\035\ \024\r.)Tj 0.088 Tw T* (\200 \b\024\007\036 \023\030\024\r\036\007\036\027\017\016 \022\024\020\027\ \017\021\017\r\027\t\b \017\027\021\036\030\r\034\033 \002\t\035\017 \r\t\ )Tj 0 Tw (-)Tj 0.069 Tw T* (\016\r\035\036\027\t \024\023\030\036\007\036\035\036\027\027\t\036 \024\ \020\030\026\027\017\004\036\027\017\016, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\036 \031\022\026)Tj 0 Tw (-)Tj 0.206 Tw T* (\026\035\017 \030\036\f\023\024\027\007\036\027\021\t. \200\024-\023\036\ \030\r\t\b, \021\024, \004\021\024 \024\023\030\024\f\027\017\022 \027\036\ )Tj 0.216 Tw T* (\031\004\017\021\t\r\026\036\021 \017\n\036\027\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\017 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036)Tj 0 Tw (-)Tj 0.079 Tw T* (\n\024\030\030\024\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\024\f\030\024\004\027\024\005 \023\036\030\f\023\036\022\ \021\017\r\036, \024\020\030\026\027\017\004\017\r\026\036\021 )Tj -0.039 Tw T* [(\036\020\024 )0.5(\023\030\017\n\036\027\036\027\017\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.468 0 Td [(\021\030\026\022\021\024\r\022\031 )0.5(\023\024\035\031\004\036\027\027\t\b )0.6(\030\036\031\035\034\021\026\021\024\r. )]TJ 0.158 Tw 15.776 64.543 Td (\200\024-\r\021\024\030\t\b, \023\030\017\n\036\027\017\n\024\f\021\034 \ \024\023\030\024\f\027\017\022\026 \f\030\036\007\017 \023\026\006\017\036\ \027)Tj 0 Tw (-)Tj 0.119 Tw T* (\021\024\r, \023\030\024\001\036\007\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\026\r\027\036\n \r\030\036\n\036\027\017 \b\017\030\031\030\ \020\017\004\036\f\022\024\036 )Tj 0.088 Tw T* (\035\036\004\036\027\017\036, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \031\004\026\f\021\027\017\022\024\r \022\024\020\ \027\017\021\017\r\027\t\b \017\027\021\036\030)Tj 0 Tw (-)Tj 0.245 Tw T* (\r\034\033, \027\036 \031\004\017\021\t\r\026\036\021 \017\b \024\023\t\021\ \026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \n\036\007\017\022\026)Tj 0 Tw (-)Tj 0.152 Tw T* (\n\036\027\021\024\027\024\005 \021\036\030\026\023\017\017, \004\021\024\ \n\024\032\036\021 \f\024\007\026\r\026\021\034 \024\013\031\013\036\027\ \017\036 )Tj 0.361 Tw T* (\027\036\007\024\f\022\026\026\027\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\035\027\024\021\t \220\021\024\020\024 \017\027\f\021\030\ \031\n\036\027\021\026. )Tj 0.324 Tw 0 -1.218 TD (\222\023\036\006\017\235\017\022\026 \024\023\030\024\f\027\017\022\026 \ \002\036 \027\036\024\002\b\024\007\017\n\t\b \026\022\006\036\027\021\024\ \r, )Tj 0.151 Tw 0 -1.218 TD (\f\007\036\035\026\027\027\t\b \023\036\030\036\007 \027\026\004\026\035\ \024\n \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\n, \n\024\032\036\021 \023\024)Tj 0 Tw (-)Tj 0.25 Tw T* (\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\023\030\017\016\021\017\036 \r\024\023\030\024\f\024\r \017, \f\ \024\024\021\r\036\021\f\021\r\036\027\027\024, )Tj 0.021 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\t. \203\026\023\030\017\n\036\030, \024\021\n\036\004\ \036\027\026 \r\036\030\024\016\021\027\024\f\021\034 \021\024\020\024, \ \004\021\024 )Tj 0.354 Tw T* [(\030\036\f\023\024\027\007\036\027\021\t \002\031\007\031\021 )0.5(\007\026\r\026\021\034 \253\031\f\030\036\007\027\036\027\027\t\036\273 \ )0.5(\024\021\r\036\021\t, )]TJ -0.043 Tw T* [(\031\004\017\021\t\r\026\033\013\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.556 0 Td [(\006\036\035\024\n \017\b )0.5(\024\023\t\021 )0.5(\027\026\035\017\004\017\016 )0.5(\020\036\n\024\030\030\024\016, \026)]TJ /Span<>> BDC ( )Tj EMC 14.576 0 Td (\027\036 )Tj 0.349 Tw -21.132 -1.218 Td (\022\024\027\022\030\036\021\027\t\005 \024\023\t\021, \024\021\030\026\032\ \026\033\013\017\005 \r\035\017\016\027\017\036 \020\036\n\024\030\030\024\ \016 )Tj 0.101 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\032\017\027\034 \023\026\006\017\036\027\021\026 \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\001\036\007\001\031\033 \027\036\007\036\035\033 \(\002\035\ \017\032\026\005)Tj 0 Tw (-)Tj 0.11 Tw 0 -1.218 TD (\001\031\033 \022)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\036 \026\023\024\035\027\036\027\017\016 \024\023\030\024\f\ \027\017\022\026\). \215\024\220\021\024\n\031 \021\030\036\002\031)Tj 0 Tw (-)Tj 0.029 Tw T* (\036\021\f\016 \022\026\022 \n\024\032\027\024 \002\024\035\036\036 \004\ \036\021\022\024 \031\022\026\t\r\026\021\034, \004\021\024 \030\036\004\ \034 \017\007\036\021 )Tj 0 Tw T* (\024\002 \017\027\021\036\030\r\026\035\036 \r\030\036\n\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\031, \002\035\017\032\026\005\001\031\033, \027\036\007\036\ \035\033.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.322 Tw 10 0 0 10 303.3071 469.0918 Tm [(\210\023\030\024\f\027\017\022 PROM-HIS)17(S, \023\030\036\007\027\026\027\026\004\036\027\027\t\005 \007\035\016 \ \024\006\036\027)]TJ 0 Tw (-)Tj 0.23 Tw T* [(\022\017 )0.5(\r\035\017\016\027\017\016 )0.6(\020\036\n\024\030\030\024\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 11.127 0 Td [(\023\024\r\f\036\007\027\036\r\027\031\033 )0.6(\026\022\021\017\r\027\024\f\021\034 )]TJ -0.011 Tw -11.127 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\034 \b\017\030\ \031\030\020\017\004\036\f\022\017\n \035\036\004\036\027\017\036\n \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj -0.041 Tw T* (\r\024\007\031 \007\026\027\027\024\020\024 \026\002\024\035\036\r\026\027\ \017\016, \023\030\024\001\036\035 \016\t\022\024\r\031\033 \r\026\035\017\ \007\026)Tj 0 Tw (-)Tj 0.033 Tw T* (\006\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \016\t\022. \221\026\022\017\n \024\002\030\026\ \024\n, \036\020\024 \235\017\027\026\035\034\027\026\016 )Tj 0.399 Tw T* [(\r\036\030\f\017\016, PROM-HIS)17(S_R)12(U, \n\024\032\036\021 \002\t\021\034 \017\f\023\024\035\034\024\r\026\027\ \026 )]TJ 0.094 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\034\027\036\005\001\036\n \022\026\022 PRO \017\027\f\021\030\ \031\n\036\027\021, \017\f\023\024\035\034\031\033\013\017\005\f\016 )Tj 0.001 Tw T* (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\031\004\027\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\024\005 \007\036\016\021\036\035\034\027\ \024\f\021\017 \030\024\f)Tj 0 Tw (-)Tj 0.16 Tw T* (\f\017\005\f\022\017\b \r\030\026\004\036\005, \026\027\017\n\026\033\013\ \017\b\f\016 \035\036\004\036\027\017\036\n \030\031\f\f\022\024\020\024\ )Tj 0 Tw (-)Tj T* (\r\024\030\016\013\017\b \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 322.9558 Tm [(\f\033\031\r\037)21(\222\034\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 303.3071 298.5998 Tm (\013\t\007\003\004\206\n\005\007\n 1)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.185 Tw 9 0 0 9 303.3071 279.2959 Tm [(\020\004\206\f\t\204\004 )0.6(1.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(\225\020\032\020\n\023\027\032\022\024\023\022\n\022 )0.6(\033\020\006\022\027\025\023\031\021, )0.6(\033\032\022\025\t\021\213\022\200 )0.6(\r\007\020)]TJ 0 Tw (-)Tj 0 -1.2 TD (\024\023\022\027 \021)Tj /Span<>> BDC ( )Tj EMC (\n\031\b\025\022\023\022\021\025\013\200 \022\025\023\027\032\021\017\005\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.035 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.008 Tw 3.332 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s w)6(h)-2.4(o p)-6.3(a)-4.2(r)-41.8(t)-29.1(i)-1.8(c)-30.1(i)1.3(p)-6.3(a)-9.2(t)-1.6(e)-12.9(d i)4(n c)2.8(o)-8.6(g)-2.4(n)1.7(i)]TJ 0 Tw 20.939 0 Td (-)Tj 0.001 Tc -0.001 Tw -24.271 -1.2 Td [(t)-28.1(i)-1.9(v)3.3(e)1.1( i)4.9(nt)-0.6(e)-5(r)-41.9(v)-31.4(ie)-7(w)-2.4(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 303.3071 242.3939 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 230.4377 cm 0 0 m 0 11.706 l S Q q 1 0 0 1 450.9586 242.3939 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 230.4377 cm 0 0 m 0 11.706 l S Q q 1 0 0 1 524.6594 230.4377 cm 0 0 m 0 11.706 l S Q q 1 0 0 1 303.3071 230.1877 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 199.0394 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 450.9586 230.1877 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 199.0394 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 524.6594 199.0394 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 303.3071 198.7894 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 186.8411 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 450.9586 198.7894 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 186.8411 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 524.6594 186.8411 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 303.3071 186.5911 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 174.6428 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 450.9586 186.5911 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 174.6428 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 524.6594 174.6428 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 303.3071 174.3928 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 143.2445 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 450.9586 174.3928 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 143.2445 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 524.6594 143.2445 cm 0 0 m 0 30.898 l S Q q 1 0 0 1 303.3071 142.9945 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 131.0462 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 450.9586 142.9945 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 131.0462 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 524.6594 131.0462 cm 0 0 m 0 11.698 l S Q q 1 0 0 1 303.3071 130.7962 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 303.5571 80.448 cm 0 0 m 0 50.098 l S Q q 1 0 0 1 450.9586 130.7962 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 450.9586 80.448 cm 0 0 m 0 50.098 l S Q q 1 0 0 1 524.6594 80.448 cm 0 0 m 0 50.098 l S Q q 1 0 0 1 303.3071 80.198 cm 0 0 m 147.652 0 l S Q q 1 0 0 1 450.9586 80.198 cm 0 0 m 73.951 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 349.6823 233.3908 Tm (\225\004\006\004\220\003\r\006\t\217\003\t\220\004)Tj 13.134 0 Td (\200\004\204\t\r\b\003\013 \(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10\))Tj /T1_0 1 Tf -18.545 -1.525 Td (\215\024\035)Tj 1.063 -1.2 Td (\204\031\032. \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj T* (\240\036\027. \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 19.998 1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj T* (5)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj -21.061 -1.525 Td (\200\024\030\026\f\021, \035\036\021 \(\f\030\036\007\027\036\036, \007\ \017\026\023\026\024\027\))Tj 20.413 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(31\22671\))Tj -20.413 -1.525 Td (\203\024\f\017\021\036\035\034 \030\031\f\f\022\024\020\024 \016\t\022\026\ \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 20.561 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj -20.561 -1.525 Td (\210\002\030\026\024\r\026\027\017\036 \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 1.063 -1.2 Td (\222\030\036\007\027\036\036-\f\023\036\006\017\026\035\034\027\024\036 \ )Tj T* (\200\t\f\001\036\036)Tj 19.998 1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj T* (7)Tj /Span<>> BDC ( )Tj EMC (\(70%\))Tj -21.061 -1.525 Td (\222\021\026\032 \020\036\n\024\030\030\024\016, \035\036\021 \(\f\030\036\ \007\027\036\036, \007\017\026\023\026\024\027\))Tj 20.663 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(3\22650\))Tj -20.663 -1.525 Td (\222\021\026\007\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (Goliger \()Tj /T1_4 1 Tf (n)Tj /T1_0 1 Tf (, %\))Tj 1.063 -1.2 Td (I)Tj T* (II)Tj T* (III)Tj T* (IV)Tj 19.998 3.6 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(30%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 20.8528 56.0378 Tm (140)Tj ET endstream endobj 702 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \213\212\217\r)10(\025\b\025\221 \n\022\r\005\025\016\016-\r\002\020\200)21(\026)-19.9(\002\005\t\025\221 \b\017\020\n\202\017\n\n )]TJ 0 -1 TD [(\025\224\005\025\016\t\n\r\017 PRO)20(M-HIS)21(S \202)-21(\020\213 \224\017\n\004\t\026)11(\025\b \016\022\013)10(\004\024\025\005\005\025\004\024)]TJ 39.217 1 Td [(Results of\022linguistic and cr)20(oss-cultur)21(al v)10(alidation of\022th)11(e )]TJ 21.255 0 Td ( )Tj -25.84 -1 Td [(PRO)20(M-HIS)21(S questionnair)31.1(e for patients with h)11(emorrh)11(oidal disease)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.214 Tw 10 0 0 10 42.5197 724.8299 Tm (\253\024\013\031\013\036\027\017\017\273, \022\024\021\024\030\024\036 \027\ \036 \024\002\016\026\021\036\035\034\027\024 \007\024\035\032\027\024 \ \023\024\007)Tj 0 Tw (-)Tj 0 -1.218 TD (\021\r\036\030\032\007\026\021\034\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\026\n\024\f\021\024\016\021\036\035\034\027\024\n \024\002\f\035\036\007\ \024\r\026\027\017\017.)Tj -0.07 Tw T* (\200 \006\036\035\024\n, \r\024\023\030\024\f \2122 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \017\n\036\033\021\f\016 \035\017 \026\021\030\031\007\027\036\ \027\017\016, \024\002)Tj 0 Tw (-)Tj 0.072 Tw T* (\031\f\035\024\r\035\036\027\027\t\036 \027\026\035\017\004\017\036\n \023\ \036\030\036\004\017\f\035\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\2121 \f\017\n\023\021\024)Tj 0 Tw (-)Tj -0.001 Tw T* (\n\024\r \020\036\n\024\030\030\024\016, \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\024\005 \032\017\027\017 \024\023\030\ \026\001\017\r\026\036\n\t\b, )Tj -0.011 Tw T* (\002\t\035 \007\035\016 \027\017\b \023\024\027\016\021\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \r\t\t\r\026\r\001\036\n \026\021\030\031\007\027\036\027\017\ \005 )Tj -0.049 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC 1.704 0 Td [(\024\021\r\036\021\036. )0.5(\210\007\027\026\022\024 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.021 0 Td [(\024\002\f\031\032\007\036\027\017\017 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 5.859 0 Td [(\023\026\006\017\036\027\021\026\n\017 )0.6(\r\t)]TJ 0 Tw (-)Tj -0.038 Tw -15.585 -1.218 Td [(\016\f\027\017\035\024\f\034, )0.6(\004\021\024 )0.6(\n\027\024\020\017\036 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.985 0 Td [(\027\017\b )0.6(\(6/10\) )0.6(\023\030\024\023\031\f\021\017\035\017 )0.6(\021\024, )0.6(\004\021\024 )]TJ 0.039 Tw -9.985 -1.218 Td (\r\024\023\030\024\f \007\026\027\027\024\020\024 \007\024\n\036\027\026\ \022\026\f\026\036\021\f\016 \021\024\035\034\022\024 \002\035\017\032\026\ \005\001\036\020\024 )Tj 0.157 Tw 0 -1.218 TD [(1-\027\036\007\036\035\034\027\024\020\024 )0.6(\024\023\t\021\026. )0.5(\221\024 )0.5(\036\f\021\034 )0.5(\030\036\f\023\024\027\007\036\027\021\t )0.6(\024\021\r\036\004\026\035\017 )]TJ 0.149 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\r\024\023\030\024\f \2122, \r\f\023\024\n\017\027\026\016 )0.5(\r\035\017\016\027\017\036 \f\017\n\023\021\024\n\024\r \027\026)]TJ /Span<>> BDC ( )Tj EMC (\017\b )Tj -0.034 Tw T* (\032\017\027\036\007\036\016\021\036\035\034\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\036 \023\036\030\017\024\007\t \021\036\004\036\027\017\016\ \002\024\035\036)Tj 0 Tw (-)Tj -0.051 Tw 0 -1.218 TD [(\027\017: )0.5(\253\022\024\020\007\026 )0.6(\002\t\035\024 )0.5(\024\002\024\f\021\030\036\027\017\036\273, )0.5(\253\r\027\036 )0.6(\024\002\024\f\021\030\036\027\017\016\273 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.637 0 Td (\021.\023. )Tj 0.029 Tw -20.637 -1.218 Td (\025\026\022 \030\036\031\035\034\021\026\021, \007\035\016 \002\024\035\ \036\036 \004\036\021\022\024\020\024 \023\024\027\017\n\026\027\017\016\ \023\026\006\017\036\027)Tj 0 Tw (-)Tj -0.026 Tw 0 -1.218 TD [(\021\024\n \020\024\030\017\024\027\021\026 )0.5(\r\030\036\n\036\027\017, )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n\031 )0.5(\024\021\027\024\f\017\021\f\016 \r\024\023\030\024\f, )]TJ 0.051 Tw T* [(\030\026\002\024\004\036\005 \020\030\031\023\023\024\005 \002\t\035\024\ \030\036\001\036\027\024 \r\t\007\036\035\017\021\034 )0.5(\021\036\022\f\021 \f)]TJ /Span<>> BDC ( )Tj EMC (\031\022\026)Tj 0 Tw (-)Tj -0.035 Tw T* [(\026\027\017\036\n \024\007\027\024\027\036\007\036\035\034\027\024\020\ \024 )0.5(\017\027\021\036\030\r\026\035\026 \032\017\030\027\t\n \001\030\017\235\ \021\024\n, )]TJ 0.202 Tw T* (\004\021\024 \f\007\036\035\026\036\021 \007\026\027\027\031\033 \017\027\ \235\024\030\n\026\006\017\033 \002\024\035\036\036 \024\004\036\r\017\007\ \027\024\005 )Tj 0 Tw T* (\007\035\016 \030\036\f\023\024\027\007\036\027\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (\002\031\007\031\013\036\n.)Tj -0.002 Tc 0.091 Tw T* (\200\024\023\030\024\f \2123 \024\002 \031\007\024\r\035\036\021\r\024\030\ \036\027\027\024\f\021\017 \023\026\006\017\036\027\021\026 \b\017\030\031\ \030\020\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.112 Tw T* (\004\036\f\022\017\n \035\036\004\036\027\017\036\n, \023\030\024\r\036\007\ \036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036 \026)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.235 Tw T* (\f\035\036\007\027\033\033 \027\036\007\036\035\033, \002\t\035, \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n, \023\024\027\016\021\036\027 \007\035\016 \024\021\r\ \036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.187 Tw T* (\004\026\033\013\017\b. \210\007\027\026\022\024, \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \021\024\020\024, \004\021\024 \007\036\r\016\021\034 \017\ )Tj /Span<>> BDC ( )Tj EMC [(\007\036\f\016\021\017)-2( )]TJ 0.077 Tw T* (\024\023\030\024\001\036\027\027\t\b \023\026\006\017\036\027\021\024\r \ \027\036 \023\030\024\b\024\007\017\035\017 \b\017\030\031\030\020\017\004\ \036\f\022\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.239 Tw T* (\020\024 \035\036\004\036\027\017\016, \r\024\023\030\024\f \r\t\t\r\026\ \035 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \024\013\031\013\036\027\017\036 \023\030\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.257 Tw T* (\027\036\002\030\036\032\036\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\027\024\005 \f\r\016\017 \024)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\r\036\007\036\027\027\024\n \017\035\017)-2( )]TJ 0.028 Tw T* (\023\030\024\r\024\007\017\n\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \n\036\007\017\022\026\n\036\027\021\024\027\024\n \035\036\004\ \036\027\017\017. \200)Tj /Span<>> BDC ( )Tj EMC [(\b\024\007\036)-2( )]TJ 0.076 Tw T* [(\024\002\f\031\032\007\036\027\017\016 )0.5(\024\021\r\036\021\024\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.039 0 Td [(\r\024\023\030\024\f )0.5(\2123 )0.6(\002\t\035\024 )0.5(\021\026\022\032\036 )0.5(\r\t\016\f)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.044 Tw -10.039 -1.218 Td [(\027\036\027\024, )0.5(\004\021\024 \004\026\f\021\024 )0.5(\017\f\023\024\035\034\031\033\013\017\036\f\016 \r)]TJ /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\017 \020\036\n\024\030\030\024\016)-2( )]TJ 0.039 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\030\024\f\f\017\005\f\022\017\b \023\026\006\017\036\027\021\024\r \n\026\ \035\024\017\027\r\026\017\r\027\t\036 \b\017\030\031\030\020\017\004\036\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.008 Tw T* (\f\022\017\036 \024\023\036\030\026\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\026\036\030\026 \027\036 \ \002\t\035\017 \031\023\024\n\016)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.081 Tw T* (\027\031\021\t \r\024\r\f\036, \004\021\024 \027\036 \023\024\r\024\035\ \017\035\024, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\n\027\036\027\017\033 \027\036\022\024\021\024\030\t\b)-2( )]TJ 0.178 Tw T* (\030\036\f\023\024\027\007\036\027\021\024\r \(3/10\), \023\024\035\027\024\ \006\036\027\027\024 \024\006\036\027\017\021\034 \017\b \031\007\024\r)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.24 Tw T* (\035\036\021\r\024\030\036\027\027\024\f\021\034 \b\017\030\031\030\020\017\ \004\036\f\022\017\n \035\036\004\036\027\017\036\n, \024)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n)-2( )]TJ 0.248 Tw T* (\f\023\030\026\001\017\r\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\036. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\220\021\017\n, \023\024\f\035\036)-2( )]TJ 0.164 Tw T* (\024\002\f\031\032\007\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\004\036\005 \020\030\031\023\023\036, \002\t\035\024 \023\ \030\017\027\016\021\024 \030\036\001\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.17 Tw T* [(\027\017\036 \007\024\023\024\035\027\017\021\034 \017\n\036\033\013\017\ \005\f\016 \023\036\030\036\004\036\027\034 \b\017\030\031\030\020\017\004\ \036\f\022\017\b)-2( )]TJ 0.047 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r \031\023\024\n\017\027\026\027\017\ \036\n \024)Tj /Span<>> BDC ( )Tj EMC (\035\026\036\030\027\024\n \031\007\026\035\036\027\017\017 \031)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.003 Tw T* (\035\024\r, \024)Tj /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n \023\026\006\017\036\027\021\t \024\004\036\027\ \034 \b\024\030\024\001\024 \024\f\r\036\007\024\n\035\036\027\t.)-2( )]TJ -0.014 Tw T* (\200\f\036 \004\035\036\027\t \030\026\002\024\004\036\005 \020\030\031\023\ \023\t \023\030\017\001\035\017 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\022\035\033\004\036\027\017\033, \004\021\024)-2( )]TJ 0.027 Tw T* [(\007\026\027\027\024\036 \007\024\023\024\035\027\036\027\017\036 )0.5(\027\036 \n\036\027\016\036\021 \f\036\n\026\027\021\017\022\031 \r\024\023\ \030\024\f\026 \2123,)-2( )]TJ -0.006 Tw T* (\027\024 \023\024\r\024\035\017\021 \023\026\006\017\036\027\021\031 \024\ \006\036\027\017\021\034 \f\r\024\036 \024\021\027\024\001\036\027\017\036\ \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.095 Tw T* (\r\036\007\036\027\027\024\n\031 \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024 \b\017\030\031\030\020\017\004\036\f\022\024\n\031 \035\ \036\004\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\004\036\021\024\n)-2( )]TJ 0.43 Tw T* [(\027\026\017\002\024\035\036\036 \030\026\f\023\030\024\f\021\030\026\027\ \036\027\027\t\b )0.5(\r\017\007\024\r )0.5(\b\017\030\031\030\020\017\004\036\f\022\017\b)-2( )]TJ 0.038 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \020\036\n\024\030\030\024\016 \r)Tj /Span<>> BDC ( )Tj EMC (\217\205. \217\016\007 \022\024\n\n\036\027)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.038 Tw T* (\021\026\030\017\036\r \(2/10\) \002\t\035 \007\026\027 \030\036\f\023\024\ \027\007\036\027\021\026\n\017 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \027\024\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.039 Tw T* (\035\024\020\017\016, \023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \022\024\021\024\030\024\005 \023\030\024\r\024\007\ \017\035\024\f\034 \b\017\030\031\030\020\017\004\036\f\022\024\036)-2( )]TJ 0.212 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\024, )0.5(\021.\036. )0.6(\020\036\n\024\030\030\024\016, )0.5(\f\021\024\017\021 )0.6(\r\027\031\021\030\017 )0.5(\f\022\024\002\024\022,)-2( )]TJ 0.091 Tw T* (\f\024\007\036\030\032\026\013\017\b \031\021\024\004\027\036\027\017\036\ \030\026\035\017\004\027\t\b \r\017\007\024\r \b\017\030\031\030\020\017\ \004\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.185 Tw T* (\f\022\017\b \r\n\036\001\026\021\036\035\034\f\021\r. \233\021\024 \023\ \030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\n\036\001\026\021\036\035\034\f\021\r\031)-2( )]TJ 0.012 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.714 0 Td [(\024\021\027\024\001\036\027\017\017 )0.5(\021\024\020\024, )0.5(\r\f\036 )0.5(\035\017 )0.5(\036\013\036 )0.5(\030\036\004\034 )0.5(\017\007\036\021 )0.5(\024\002 )0.5(\031\022\026\026\027\027\024\005)-2( )]TJ 0.11 Tw -0.714 -1.218 Td (\002\024\035\036\027\017 \017\035\017 \032\036 \017\b \f\023\030\026\001\ \017\r\026\033\021 \024\002 \031\007\024\r\035\036\021\r\024\030\036\027\ \027\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.024 Tw T* (\f\021\017 \035\033\002\t\n\017 \007\030\031\020\017\n\017 \b\017\030\031\ \030\020\017\004\036\f\022\017\n\017 \r\n\036\001\026\021\036\035\034\f\021\ \r\026)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.139 Tw T* (\n\017, \022\024\021\024\030\t\n \024\027\017 \n\024\020\035\017 \023\024\ \007\r\036\030\020\027\031\021\034\f\016 \026)Tj /Span<>> BDC ( )Tj EMC [(\023\024\f\035\036\007\027\036\036)-2( )]TJ 0.094 Tw 23.244 64.543 Td [(\r\030\036\n\016. \221\026\022, \027\026\023\030\017\n\036\030, \027\036\ \f\022\024\035\034\022\024 \023\026\006\017\036\027\021\024\r \f\022\026\ \026\035\017,)-2( )]TJ 0.03 Tw T* [(\004\021\024 )0.5(\f\027\026\004\026\035\026 \002\t\035\017 \f\024\n\027\036\027\017\016, \ \004\021\024 )0.5(\017\b \f\023\030\026\001\017\r\026\033\021 \024)]TJ /Span<>> BDC ( )Tj EMC 20.82 0 Td (\035\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.017 Tw -20.82 -1.218 Td (\004\036\027\017\017 \020\036\n\024\030\030\024\016, \017, \004\021\024 \ \036\f\035\017 \002\t \r)Tj /Span<>> BDC ( )Tj EMC [(\r\024\023\030\024\f\036 \031\023\024\n\017\027\026\027\017\036)-2( )]TJ 0.053 Tw T* (\020\036\n\024\030\030\024\016 \002\t\035\024 \002\t \r\t\027\036\f\036\027\ \024 \026)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\002\022\017, \021\024 \220\021\024 \024\002\035\036\020)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.124 Tw T* [(\004\026\035\024 )0.5(\002\t )0.5(\002\024\035\036\036 )0.5(\035\036\020\022\024\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 10.439 0 Td [(\002\t\f\021\030\024\036 )0.5(\r\024\f\023\030\017\016\021\017\036 )0.5(\r\024\023\030\024)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.275 Tw -10.439 -1.218 Td (\f\026. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\026\n \007\026\027\027\t\b \022\024\n\n\ \036\027\021\026\030\017\036\r \030\026\002\024\004\036\005)-2( )]TJ -0.022 Tw 0 -1.218 TD (\020\030\031\023\023\024\005 \030\036\001\036\027\024 \002\t\035\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\235\017\027\026\035\034\027\024\005 \r\036\030\f\017\017 \024\023\030\024\ \f\027\017\022\026)-2( )]TJ 0.238 Tw 0 -1.218 TD [(\031\023\024\n\017\027\026\027\017\036 \f\026\n\024\005 \027\024\024\035\ \024\020\017\017, \020\036\n\024\030\030\024\016, \023\036\030\036\027\036\ \f\021\017)-2( )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\022\024\002\024\022 \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \021\036\022\f\021.)Tj 0 Tc 0.227 Tw T* (\200 \006\036\035\024\n, \023\024\f\035\036 \023\030\024\r\036\007\036\027\ \017\016 \022\024\020\027\017\021\017\r\027\t\b \017\027\021\036\030\r\034\ \033 )Tj 0.302 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024 \017\b \030\036\031\035\034\021\026\021\026\n \f\007\036\035\026\ \027 \r\t\r\024\007, \004\021\024 \024\023\030\024\f\027\017\022 )Tj 0.119 Tw T* (\r\024\f\023\030\017\027\017\n\026\036\021\f\016 \031\004\026\f\021\027\017\ \022\026\n\017 \023\024\017\021\017\r\027\024: \036\020\024 \f\024\007\036\ \030)Tj 0 Tw (-)Tj 0.197 Tw 0 -1.218 TD [(\032\017\n\024\036 \f\024\024\021\r\036\021\f\021\r\031\036\021 )0.5(\023\030\036\007\f\021\026\r\035\036\027\017\016\n \017)]TJ /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\027\017\016\n )Tj 0.161 Tw 0 -1.218 TD [(\023\026\006\017\036\027\021\024\r )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\f\026\n\024\n \026\002\024\035\036\r\026\027\017\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\036\020\024 )0.5(\r\024\007\036\005\f\021\r\017\017 )]TJ 0.101 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\024\r\f\036\007\027\036\r\027\031\033 \032\017\027\034. \217\ \036\f\023\024\027\007\036\027\021\026\n\017 \024\021\n\036\004\036\027 \ )Tj 0.053 Tw T* (\b\024\030\024\001\024 \r\024\f\023\030\017\027\017\n\026\036\n\t\005, \023\ \030\026\r\017\035\034\027\t\005 \030\031\f\f\022\017\005 \016\t\022, )Tj 0.057 Tw T* [(\022\024\021\024\030\t\n \027\026\023\017\f\026\027 )0.5(\024\023\030\024\f\027\017\022, )0.5(\031\022\026\026\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\b\024\030\024\001\031\033 )0.5(\r\017)]TJ 0 Tw (-)Tj -0.027 Tw T* (\031\026\035\017\026\006\017\033 \007\024\n\036\027\024\r, \r\t\f\024\022\ \024 \024\006\036\027\036\027\026 \022\030\026\021\022\024\f\021\034 \235\ \024\030)Tj 0 Tw (-)Tj 0.021 Tw T* (\n\031\035\017\030\024\r\024\022, \n\017\027\017\n\031\n \r\030\036\n\036\ \027\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031\f\017\035\017\005, \022\024\021\024\030\t\036 \021\030\036)Tj 0 Tw (-)Tj -0.038 Tw T* (\002\031\033\021\f\016 \007\035\016 \036\020\024 \026\023\024\035\027\036\ \027\017\016. \221\026\022\032\036, \023\024)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\026\n \024\023\030\024\f\024\r )Tj 0.033 Tw T* (\002\t\035\024 \f\007\036\035\026\027\024 \026\022\035\033\004\036\027\017\ \036, \004\021\024 \017\f\023\024\035\034\031\036\n\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (PROM )Tj 0.238 Tw T* [(HIS)17(S_R)12(US )0.5(10-\002\026\035\035\034\027\t\036 )0.6(\004\017\f\035\024\r\t\036 )0.6(\001\022\026\035\t )0.5(\024\006\036\027\022\017 )0.6(\024\021 )]TJ 0.214 Tw T* (0 \007\024)Tj /Span<>> BDC ( )Tj EMC (10, \020\007\036 0 \024\002\024\027\026\004\026\035 \253\f\024\r\f\036\n\ \027\036 \026\021\030\031\007\027\036\027\024\273, )Tj -0.029 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (10)Tj /Span<>> BDC ( )Tj EMC [(\227 \253\024\004\036\027\034 \026\021\030\031\007\027\036\027\024\273 \ )0.5(\002\t\035\017 \023\026\006\017\036\027\021\026\n \023\024\027\016\021\027\ \t, )]TJ 0.168 Tw T* (\023\024\r\024\035\016\035\017 \035\036\020\022\024 \f\007\036\035\026\021\ \034 \024\021\n\036\021\022\031, \f\024\024\021\r\036\021\f\021\r\031\033\ \013\031\033 )Tj 0.01 Tw T* (\017\b \024\023\t\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\027\031\032\027\024\n\031 \r\026\030\017\026\027\021\031 \024\021\r\036\ \021\026. \221\026\022\017\n \024\002\030\026\024\n, )Tj 0.153 Tw T* (\030\026\002\024\004\026\016 \020\030\031\023\023\026 \f\007\036\035\026\ \035\026 \r\t\r\024\007 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \024\023\030\024\f\027\017\022 )Tj 0.127 Tw T* [(PROM-HIS)17.1(S_R)11.9(US \024\002\035\026\007\026\036\021 \007\024\f\021\026\021\024\004\027\024\ \005 \022\026\022 \r\027\036\001\027\036\005, )]TJ 0.074 Tw T* (\021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\036\030\032\026\021\036\035\034\027\024\005 \r\026\035\017\007\ \027\024\f\021\034\033, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.318 Tw T* (\024\r\026\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\020\024\r\024\030\016\013\036\005 \023\024\023\031\035\ \016\006\017\017 \023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n, \023\030\024\032\017\r\026\033\013\017\ \b \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\036\030\030\017\021\024\030\017\017 \217\205.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 322.9558 Tm [(\230\031\032\027)10(\224)1(\032\032\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.166 Tw 10 0 0 10 274.9606 298.5998 Tm (\217\036\031\035\034\021\026\021\t \023\030\024\r\036\007\036\027\027\024\ \005 \027\026\n\017 \016\t\022\024\r\024\005 \r\026\035\017\007\026\006\ \017\017 )Tj 0.044 Tw T* [(\020\024\035\035\026\027\007\f\022\024\020\024 \024\023\030\024\f\027\017\ \022\026 PROM-HIS)17.1(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \016\t\022 )Tj 0.061 Tw T* (\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\017 \b\024\ \030\024\001\031\033 \r\027\036\001\027\033\033 \r\026\035\017\007\027\024\ \f\021\034 )Tj 0.19 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\035\034 \032\036 \r\t\f\024\022\024\005 \f\021\030\031\022\021\ \031\030\027\024\005 \r\026\035\017\007\027\024\f\021\017 \036\020\024 )Tj 0.068 Tw T* [(\030\031\f\f\022\024\016\t\004\027\024\005 )0.6(\r\036\030\f\017\017. )0.5(\233\021\024 )0.5(\023\024\r\024\035\016\036\021 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.033 0 Td (\007\026\035\034\027\036\005\001\036\n )Tj 0.315 Tw -17.033 -1.218 Td (\017\f\023\024\035\034\024\r\026\021\034 \007\026\027\027\t\005 \024\023\ \030\024\f\027\017\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036 )Tj 0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.73 0 Td [(\022\026\004\036\f\021\r\036 )0.5(\017\027\f\021\030\031\n\036\027\021\026 )0.5(\007\035\016 )0.5(\017\031\004\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.869 0 Td [(\024\006\036\027\022\017 )0.5(\r\035\017\016)]TJ 0 Tw (-)Tj 0.012 Tw -16.599 -1.218 Td (\027\017\016 \f\017\n\023\021\024\n\024\r \020\036\n\024\030\030\024\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \032\017\027\034 \023\026)Tj 0 Tw (-)Tj 0.012 Tw T* (\006\017\036\027\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \022\026\004\036\f\021\r\024, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\006\036\027\017\021\034 \031\007\024\r\035\036\ \021\r\024\030\036\027)Tj 0 Tw (-)Tj 0.085 Tw T* (\027\024\f\021\034 \023\026\006\017\036\027\021\026 \023\030\024\r\024\007\ \017\n\t\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \026\002\024\035\036\r\026\027\017\016 )Tj 0.147 Tw T* (\024\023\036\030\026\021\017\r\027\t\n \035\036\004\036\027\017\036\n. \221\ \024\021 \235\026\022\021, \004\021\024 \024\023\030\024\f\027\017\022 \017\ \f)Tj 0 Tw (-)Tj 0.046 Tw T* (\b\024\007\027\024 \f\024\007\026\027 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\017 \023\026\006\017\036\027\021\024\r [6], \004\021\ \024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 )Tj 0.129 Tw T* (\024\004\036\030\036\007\034, \016\r\035\016\036\021\f\016 \027\036\024\021\ \255\036\n\035\036\n\t\n \031\f\035\024\r\017\036\n \007\035\016 \f\024\ )Tj 0 Tw (-)Tj 0.157 Tw T* (\007\026\027\017\016 PROM, \017)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \024\027 \r\022\035\033\004\026\036\021 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \r\024\023\030\024\f\t )Tj -0.019 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC 0.713 0 Td [(\f\017\n\023\021\024\n\026\b, )0.5(\016\r\035\016\033\013\017\b\f\016 )0.6(\024\f\027\024\r\027\t\n\017 )0.5(\f\017\n\023\021\024\n\026\n\017 )0.6(\020\036)]TJ 0 Tw (-)Tj 0.028 Tw -0.713 -1.218 Td (\n\024\030\030\024\016, \r\f\036 \220\021\024 \023\024\r\024\035\016\036\ \021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 PROM-)Tj -0.051 Tw T* [(HIS)17(S \023\024\035\031\004\026\021\034 \024\006\036\027\022\031 \017\031\004\ \026\036\n\t\b \023\026\030\026\n\036\021\030\024\r \024\021 \f\026\n\017\ \b )]TJ -0.033 Tw T* (\023\026\006\017\036\027\021\024\r, \004\021\024 \022\030\026\005\027\036\ \r\026\032\027\024 \007\035\016 \023\024\027\017\n\026\027\017\016 \021\ \024\020\024, \022\026\022 )Tj 0.096 Tw T* (\002\024\035\036\027\034 \r\035\017\016\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\024\016\027\017\036 \022\024\027\022\030\036\021\027\024\020\ \024 \023\026\006\017\036\027\021\026, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_3 1 Tf 25 0 0 25 505.4895 56.0378 Tm (139)Tj ET endstream endobj 701 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.042 Tw 10 0 0 10 70.8661 724.8299 Tm (\023\030\017\004\017\027\024\005 \027\036\016\f\027\024\f\021\017, \024)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\024\005 \022\024\027\022\030\036\021\027\024 \024\023\036\030\ \026\006\017\017 \036\020\024 )Tj 0.019 Tw 0 -1.218 TD [(\f\023\030\026\001\017\r\026\033\021, \030\036\001\036\027\024 \017\f\023\ \024\035\034\024\r\026\021\034 )0.5(\024\023\030\036\007\036\035\036\027\017\036 \253\b\017)]TJ 0 Tw (-)Tj T* (\030\031\030\020\017\004\036\f\022\024\036 \031\007\026\035\036\027\017\036\ \020\036\n\024\030\030\024\016\273.)Tj 0.152 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \023\024\f\035\036 \023\030\016\ \n\024\020\024 \023\036\030\036\r\024\007\026 \024\023\030\024\f\027\017\ \022\026 )Tj 0.02 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\f\031\032\007\036\027\017\016 \017\n\036\033\013\017\b\f\016 )Tj 0.081 Tw T* (\030\026\027\024\004\021\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\026\b, \r\t\023\024\035\027\036\027\027\t\b \007\ \r\031\n\016 \027\036\026)Tj 0 Tw (-)Tj 0.111 Tw 0 -1.218 TD [(\r\017\f\017\n\t\n\017 )0.5(\023\030\024\235\036\f\f\017\024\027\026\035\034\027\t\n\017 \023\036\030\ \036\r\024\007\004\017\022\026\n\017, )0.6(\f\021\026)]TJ 0 Tw (-)Tj 0.209 Tw 0 -1.218 TD [(\035\024 )0.5(\r\024\n\024\032\027\024 )0.6(\f\024\007\026\027\017\036 )0.5(\210\222\200 )0.6(\024\023\030\024\f\027\017\022\026 )0.5(PROM-HIS)17.1(S_)]TJ 0.05 Tw T* [(R)12(US, \022\024\021\024\030\026\016 \026\021\036\n \023\024\007\r\036\030\020\ \035\026\f\034 \024\002\030\026\021\027\024\n\031 \023\036\030\036\r\024\ \007\031 )]TJ -0.017 Tw T* [(\024\007\027\017\n, \030\026\027\036\036 )0.5(\027\036 \r\024\r\035\036\004\036\027\027\t\n )0.5(\023\036\030\036\r\024\007\004\017\022\024\n, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.114 Tw T* (\023\030\024\r\036\030\022\017 \f\024\b\030\026\027\036\027\017\016 \f\n\ \t\f\035\024\r\t\b \027\026\004\036\027\017\005 \007\024\n\036\027\024\r\ )Tj 0.302 Tw T* (\024\023\030\024\f\027\017\022\026. \215\024\035\031\004\036\027\027\026\ \016 \r\036\030\f\017\016 \024\002\030\026\021\027\024\020\024 \023\036\030\ \036\r\024)Tj 0 Tw (-)Tj 0.332 Tw 0 -1.218 TD (\007\026 \024\023\030\024\f\027\017\022\026 \023\024\007\r\036\030\020\035\ \026\f\034 \030\036\r\034\033\017\030\024\r\026\027\017\033, \004\021\024\ \002\t )Tj 0.068 Tw 0 -1.218 TD [(\031\002\036\007\017\021\034\f\016, \004\021\024 \022\024\027\006\036\023\ \021\031\026\035\034\027\024 )0.5(\023\036\030\036\r\024\007 \220\022\r\017\r\026\035\036\027\021\036\027 \ )]TJ 0.205 Tw 0 -1.218 TD [(\024\030\017\020\017\027\026\035\031. \215\024\021\030\036\002\024\r\026\ \035\026\f\034 )0.5(\r\f\021\030\036\004\026 \030\026\002\024\004\036\005 \020\030\031\023\023\ \t )]TJ 0.044 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\004\017\022\024\n \007\035\016 \024\002\f\031\ \032\007\036\027\017\016 \017\n\036\027\036\027\017\005, \r\027\036\f\036\ \027)Tj 0 Tw (-)Tj 0.091 Tw T* (\027\t\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\t\007\031\013\036\n \220\021\026\023\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\031\033 \r\036\030\f\017\033, )Tj 0.204 Tw T* (\023\024\007\r\036\030\020\001\031\033\f\016 \024\002\030\026\021\027\024\ \n\031 \023\036\030\036\r\024\007\031. \200\027\036\f\036\027\027\t\036 \ \017)Tj 0 Tw (-)Tj 0.225 Tw T* (\n\036\027\036\027\017\016 \023\030\017\027\026\027\t \r\f\036\n\017 \031\ \004\026\f\021\027\017\022\026\n\017 \024\002\f\031\032\007\036\027\017\016\ )Tj 0.509 Tw T* (\027\036\024\002\b\024\007\017\n\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \017\n\036\027\016\033\013\017\n\017 \022\024\027\006\036\023\021\ \031\026\035\034)Tj 0 Tw (-)Tj 0.204 Tw T* [(\027\024 \f\n\t\f\035 )0.5(\024\030\017\020\017\027\026\035\034\027\024\020\024 )0.5(\024\023\030\024\f\027\017\022\026 \017)]TJ /Span<>> BDC ( )Tj EMC 16.819 0 Td (\036\020\024 \007\024\n\036\027\024\r )Tj 0 Tw -16.819 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\024\f\021\017.)Tj /T1_1 1 Tf 0.186 Tw 0 -2.436 TD [(\021\006\002\217\217-\220\210\f\001\003\210\006\b\004\235 )0.6(\212\006\002\r\006\220\004 )0.6(\(\004\f\t\240\004\204\t\235\) )0.5(\006\210\217\217\220\002)]TJ /Span<>> BDC (-)Tj EMC 0 Tw 0 -1.218 TD (\235\213\013\201\b\002\005 \r\006\217\t\t)Tj /T1_0 1 Tf 0.287 Tw T* (\203\026 \220\021\024\n \220\021\026\023\036 \n\t \023\030\024\021\036\f\ \021\017\030\024\r\026\035\017 \210\222\200 \024\023\030\024\f\027\017\022\ \026 )Tj 0.002 Tw T* [(PROM-HIS)17.1(S_R)12(US \f\030\036\007\017 \023\026\006\017\036\027\021\024\r \f)]TJ /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\235\024\030)Tj 0 Tw (-)Tj -0.012 Tw T* [(\n\026\021\036 )0.5(\022\024\020\027\017\021\017\r\027\024\020\024 )0.5(\017\027\021\036\030\r\034\033. )0.6(\222)]TJ /Span<>> BDC ( )Tj EMC 13.106 0 Td [(\220\021\024\005 )0.5(\006\036\035\034\033 )0.6(\027\026\n\017 )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.174 Tw -13.106 -1.218 Td (\r\035\036\022\026\035\017\f\034 \f\023\036\006\017\026\035\017\f\021\t \ \021\030\036\021\034\036\005 \f\021\024\030\024\027\t \(\026\020\036\027\ \021\f\021\r\024 )Tj 0.254 Tw T* [(TRENCH INSIGHT)25.1(S\), \f\023\036\006\017\026\035\017\017\030\031\033\013\036\036\f\016 \027\ \026)]TJ /Span<>> BDC ( )Tj EMC (\021\026\022\024\020\024 )Tj 0 Tw T* (\030\024\007\026 \017\027\021\036\030\r\034\033\017\030\024\r\026\027\017\ \017.)Tj 0.074 Tw T* [(\200 \022\024\020\027\017\021\017\r\027\024\036 \017\027\021\036\030\r\034\ \033\017\030\024\r\026\027\017\036 )0.5(\002\t\035\017 \023\030\017\020\035\026\001\036\027\t )]TJ 0.116 Tw T* (10 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n\017 \f\021\026\007\017\016\n\017 \b\030\024\ \027\017\004\036\f\022\024\020\024 )Tj 0.243 Tw T* (\020\036\n\024\030\030\024\016 \023\024)Tj /Span<>> BDC ( )Tj EMC [(Gol)-30.9(igher. \200\f\036 \023\026\006\017\036\027\021\t \023\030\036\007\024\f\021\ \026\r\017\035\017 )]TJ 0.135 Tw T* (\017\027\235\024\030\n\017\030\024\r\026\027\027\024\036 \f\024\020\035\026\ \f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\034\033. )Tj 0.028 Tw T* (\210\f\027\024\r\027\t\036 \b\026\030\026\022\021\036\030\017\f\021\017\022\ \017 \031\004\026\f\021\027\017\022\024\r \031\022\026\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002)Tj 0 Tw (-)Tj 0.246 Tw T* (\035\017\006\036 1 \(\215\030\017\035\024\032\036\027\017\036\). \215\026\ \006\017\036\027\021\026\n \002\t\035\024 \023\030\036\007\035\024\032\036\ )Tj 0 Tw (-)Tj 0.127 Tw T* (\027\024 \024\027\026\022\024\n\017\021\034\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\017\021\034 \210\222\200 \024\023\030\024\f\027\017\ \022\026, \023\024\f\035\036 )Tj 0.036 Tw T* (\004\036\020\024 \017\b \f\023\030\026\001\017\r\026\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\021\036 \017\027\f\021\030\031\022\006\017\005, \r\024\ \023\030\024\f\024\r )Tj 0.196 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\027\021\024\r \024\021\r\036\021\024\r, \r\022\035\033\ \004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024 \(\r\027\036\001\027\016\016 )Tj -0.023 Tw T* (\r\026\035\017\007\027\024\f\021\034\) [10]. \025\030\024\n\036 \021\024\ \020\024, \023\026\006\017\036\027\021\024\r \023\030\024\f\017\035\017 \ \r\t)Tj 0 Tw (-)Tj 0.277 Tw T* (\f\022\026\026\021\034 \n\027\036\027\017\036 \022\026\f\026\021\036\035\ \034\027\024 \030\036\035\036\r\026\027\021\027\024\f\021\017 \023\031\027\ \022\021\024\r )Tj 0.057 Tw T* (\024\023\030\024\f\027\017\022\026 \017\b \f\024\002\f\021\r\036\027\027\ \024\n\031 \024\023\t\021\031 \032\017\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024)Tj 0 Tw (-)Tj 0.13 Tw T* (\036\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024 \027\036\007\024\f\021\026\033\013\017\b \030\026\ \007\036\035\026\b \017\035\017 )Tj 0.196 Tw T* (\023\031\027\022\021\026\b, \022\024\021\024\030\t\036 \023\024\n\024\020\ \035\017 \002\t \023\024\035\027\024\006\036\027\027\024 \024\021\030\026\ \017\021\034 )Tj 0.037 Tw T* (\r\f\036 \026\f\023\036\022\021\t \027\026\035\017\004\017\016 \020\036\n\ \024\030\030\024\016 \031)Tj /Span<>> BDC ( )Tj EMC [(\023\026\006\017\036\027\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\036 )Tj -0.028 Tw T* [(\026\002\024\035\036\r\026\027\017\016 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.659 0 Td [(\022\026\004\036\f\021\r\024 )0.5(\032\017\027\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.415 0 Td (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\017 )Tj 0.018 Tw -14.074 -1.218 Td (\023\030\024\r\024\007\017\n\t\n \035\036\004\036\027\017\036\n \(\f\024\ \007\036\030\032\026\021\036\035\034\027\026\016 \r\026\035\017\007\027\024\ \f\021\034\) )Tj 0.21 Tw T* ([10]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\017 \024\023\030\024\f\027\017\022\026\ \027\026\n\017 \235\017\022\f\017\030\024\r\026)Tj 0 Tw (-)Tj 0.048 Tw T* (\035\024\f\034 \r\030\036\n\016, \021\030\036\002\031\033\013\036\036\f\016\ \022\026\032\007\024\n\031 \031\004\026\f\021\027\017\022\031 \007\035\016\ \026)Tj 0 Tw (-)Tj T* (\r\036\030\001\036\027\017\016 \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\n.)Tj 0.205 Tw T* (\200 \006\036\035\024\n, \r\f\036 \031\004\026\f\021\027\017\022\017 \f\n\ \024\020\035\017 \024\021\r\036\021\017\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024)Tj 0 Tw (-)Tj 0.078 Tw T* (\f\t \024\023\030\024\f\027\017\022\026 \f\026\n\024\f\021\024\016\021\036\ \035\034\027\024, \007\035\016 \004\036\020\024 \021\030\036\002\024\r\026\ \035\024\f\034 )Tj 0.08 Tw T* (\024\022\024\035\024 \024\007\027\024\005 \n\017\027\031\021\t \(\007\017\ \026\023\026\024\027 \024\021 40 \007\024)Tj /Span<>> BDC ( )Tj EMC (70 \f\036\022\031\027\007\). )Tj 0.187 Tw 23.244 64.543 Td [(\200\f\036 \031\004\026\f\021\027\017\022\017 )0.5(\017\027\021\036\030\r\034\033 )0.5(\024\021\n\036\021\017\035\017, \004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b )Tj 0.04 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\t \017\n \031\007\026\035\024\f\034 \024\021\030\026\ \017\021\034 \024\f\024\002\036\027\027\024\f\021\017 \f\r\024\036\020\024\ )Tj -0.003 Tw T* [(\f\024\f\021\024\016\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.204 0 Td [(\024\021\n\036\021\017\035\017 )0.6(\f\024\024\021\r\036\021\f\021\r\017\036 )0.5(\r\024\023\030\024\f\024\r )0.5(\031\030\024\r\027\033 )]TJ 0.143 Tw -5.204 -1.218 Td [(\017\b )0.5(\024\002\030\026\024\r\026\027\017\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.942 0 Td [(\r\020\035\016\007\026\n )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 5.472 0 Td [(\002\024\035\036\027\034. )0.6(\231\022\026\035\t, )0.5(\017\f)]TJ 0 Tw (-)Tj 0.131 Tw -13.414 -1.218 Td (\023\024\035\034\024\r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\210\222\200, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \031\004\026\f\021\027\017\022\024\r, \023\024\027\ \016\021)Tj 0 Tw (-)Tj 0.071 Tw T* (\027\t, \007\026\033\021 \r\024\n\024\032\027\024\f\021\034 \024\021\030\ \026\017\021\034 \f\021\036\023\036\027\034 \r\t\030\026\032\036\027\027\ \024)Tj 0 Tw (-)Tj 0.272 Tw 0 -1.218 TD (\f\021\017 \f\017\n\023\021\024\n\024\r/\023\030\024\002\035\036\n, \024\ \002\031\f\035\024\r\035\036\027\027\t\b \002\024\035\036\027\034\033. \ )Tj 0.096 Tw 0 -1.218 TD [(\215\036\030\036\004\036\027\034 )0.5(\f\017\n\023\021\024\n\024\r \002\024\035\036\027\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\2121 \023\024\004\021\017 \023\024\035\027\024\f\021\034\033 )Tj 0.005 Tw T* (\f\024\024\021\r\036\021\f\021\r\024\r\026\035 \024\032\017\007\026\027\017\ \016\n \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\030\036\007\f\021\026\r)Tj 0 Tw (-)Tj 0.074 Tw T* (\035\036\027\017\016\n \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\016\b \020\036\n\024\030\030\024\016:\ \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\253\r\t\007\036\035\036)Tj 0 Tw (-)Tj 0.058 Tw T* (\027\017\017 \022\030\024\r\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\020\024 \023\030\024\b\024\007\026\273 \002\t\035 \023\ \024\027\016\021\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\035\036)Tj 0 Tw (-)Tj 0.149 Tw T* (\r\026\027\021\036\027 \007\035\016 10 \017)Tj /Span<>> BDC ( )Tj EMC (10 \024\023\030\024\001\036\027\027\t\b, \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \253\002\024\035\017 )Tj 0.029 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 \026\007\027\036\020\024 )0.5(\023\030\024\b\024\007\026\273)]TJ /Span<>> BDC ( )Tj EMC 11.917 0 Td [(\227 )0.5(\007\035\016 \007\036\r\016\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 7.239 0 Td (\007\036\f\016\021\017, )Tj -0.035 Tw -19.156 -1.218 Td (\024)Tj /Span<>> BDC ( )Tj EMC [(\253\r\t\023\026\007\036\027\017\017 \020\036\n\024\030\030\024\017\007\026\ \035\034\027\t\b \031\035\024\r/\024\013\031\013\036\027\017\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.036 Tw 0 -1.218 TD (\002\031\b\026\027\017\016\273)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \r\024\f\034\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017, \024)Tj /Span<>> BDC ( )Tj EMC (\253\031\007\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 )Tj 0.127 Tw T* (\026\007\027\036\020\024 \023\030\024\b\024\007\026\273)Tj /Span<>> BDC ( )Tj EMC (\227 \007\035\016 \f\036\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017 \023\026\006\017\036\027\021\024\r )Tj 0.114 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\034\022\024 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \253\r\024\007\016\027\017\f\021\t\b \r\t\007\ \036\035\036\027\017\005 )Tj 0.046 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\026\007\027\036\020\024 \023\030\024\b\024\007\026\273 \002\t\035 \030\ \036\035\036\r\026\027\021\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\016\021\036\027 \021\030\036\n )Tj 0.022 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017 \024\023\030\024\001\036\027\027\t\b. \221\030\017\ \031\022\026\026\027\027\t\b \023\026\006\017\036\027\021\026 \f\022\026\ )Tj 0 Tw (-)Tj 0.058 Tw T* (\026\035\017, \004\021\024 \007\026\027\027\t\005 \f\017\n\023\021\024\n\ \017\n \027\026\022\024\n, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \021\024\035\034)Tj 0 Tw (-)Tj 0.079 Tw T* (\022\024 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031\022\026\026\035, \004\021\024 \017\n\036\036\021 \f\024\ \002\f\021\r\036\027\027\t\005 \024\023\t\021, )Tj 0.017 Tw T* (\f\r\016\026\027\027\t\005 \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\007\016\027\017\f\021\t\n\017 \r\t\007\036\035\036\027\017\016\n\017\ . )0.5(\210\f\021\026\r\001\017\036\f\016 )]TJ 0.088 Tw T* (\f\036\n\034 \030\036\f\023\024\027\007\036\027\021\024\r, \031\022\026\ \026\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \024\027\017 \027\036 \017\n\036\035\017 )Tj 0.072 Tw T* (\024\023\t\021\026 \027\026\035\017\004\017\016 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \031\022\026\026\027\027\024\020\024 \f\017\n\023\021\024\n\026\ \020\036\n\024\030\030\024\016 )Tj 0.025 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\220\021\024\n\031 \r\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\030\026\032\036\027\027\024\f\021\017 \r\024\007\016\027\017\f\021\t\ \b \r\t\007\036)Tj 0 Tw (-)Tj -0.055 Tw T* (\035\036\027\017\005 \r\t\t\r\026\035 \031)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \027\036\022\024\021\024\030\024\036 \026\021\030\031\007\027\ \036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\036.)Tj 0.218 Tw T* (\200\024\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\026\007\036\027\017\017 \020\036\n\024\030\030\024\017\007\026\035\ \034\027\t\b \031\035\024\r \(\206\211\)/)Tj 0.83 Tw T* (\024\013\031\013\036\027\017\017 \r\t\002\031\b\026\027\017\016 \r\t\t\r\ \026\035 \026\n\036\001\026\021\036\035\034\f\021\r\024 )Tj 0.24 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b, \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \023\030\017\004\017\027. \210\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \002\t\035\024, )Tj 0.578 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \027\036\022\024\021\024\030\t\b \030\036\f\023\024\ \027\007\036\027\021\024\r, \024\002\255\036\007\017\027\036)Tj 0 Tw (-)Tj 0.147 Tw T* (\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\024\023\030\024\f\036 \007\r\031\b \f\017\n\023\021\024\ \n\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027 \024\002\013\017\005. )Tj 0.281 Tw T* (\211\022\026\026\027\027\t\005 \r\024\023\030\024\f \027\036 \r\t\t\r\026\ \035 \f\035\024\032\027\024\f\021\036\005 \021\024\035\034\022\024 )Tj 0.15 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \021\016\032\036\035\t\n\017 \f\021\026\007\017\016\ \n\017 \020\036\n\024\030\030\024\016: )Tj 0.03 Tw T* [(III )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(IV )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC [(Gol)-30.9(igher \(5/10, )0.5(50%\), )0.5(\r\r\017\007\031 \027\026\035\017\004\017\016 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC (\027\017\b )Tj 0.164 Tw T* (\024\023\t\021\026 \032\017\027\017 \f)Tj /Span<>> BDC ( )Tj EMC (\024\002\024\017\n\017 \f\024\f\021\024\016\027\017\016\n\017, \022\026\022\ \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\026\007\036)Tj 0 Tw (-)Tj 0.048 Tw T* (\027\017\036\n \206\211, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\f \024\013\031\013\036\027\017\036\n \r\t\002\031\b\026\027\017\016, \022\ \024\021\024\030\t\036 \024\027\017 )Tj 0.239 Tw T* (\f\r\016\t\r\026\033\021 \n\036\032\007\031 \f\024\002\024\005 \022\026\ \022 \024\021\030\026\032\036\027\017\036 \030\026\035\017\004\027\024\005\ )Tj 0.341 Tw T* (\f\021\036\023\036\027\017 \r\t\030\026\032\036\027\027\024\f\021\017 \024\ \007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\020\024 \032\036 \f\024\f\021\024\016)Tj 0 Tw (-)Tj -0.016 Tw T* (\027\017\016)Tj /Span<>> BDC ( )Tj EMC 1.717 0 Td [(\227 )0.6(\r\024\r\035\036\004\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.946 0 Td [(\023\026\021\024\035\024\020\017\004\036\f\022\017\005 )0.6(\023\030\024\006\036\f\f )0.6(\206\211. )0.6(\200)]TJ /Span<>> BDC ( )Tj EMC 12.567 0 Td (\021\024 )Tj 0.059 Tw -21.23 -1.218 Td (\032\036 \r\030\036\n\016 \023\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\253\035\036\020\022\024\005\273 \022\035\017\027\017\004\036\f\022\024\005\ \235\024\030\n\024\005 )Tj 0.187 Tw T* (\020\036\n\024\030\030\024\016 \004\026\013\036 \030\026\007\031\n\t\r\026\ \035\017 \027\026\007 \021\036\n, \022\026\022 \023\030\026\r\017\035\034\ )Tj 0 Tw (-)Tj 0.14 Tw T* [(\027\024 )0.5(\024\021\r\036\021\017\021\034, )0.6(\036\f\035\017 )0.5(\027\026\002\031\b\026\027\017\036 )0.5(\036\f\021\034, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 15.567 0 Td [(\r\t\023\026\007\036\027\017\016 )0.5(\027\036\021. )]TJ 0.221 Tw -15.567 -1.218 Td [(\215\024\f\035\036 \024\002\f\031\032\007\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 9.324 0 Td [(\030\026\002\024\004\036\005 \020\030\031\023\023\036 )0.5(\002\t\035\024 \030\036\001\036\027\024 )]TJ 0.21 Tw -9.324 -1.218 Td (\024\021\f\036\023\026\030\017\030\024\r\026\021\034 \007\r\026 \r\t\001\ \036 \024\002\024\027\026\004\036\027\027\t\b \f\024\f\021\024\016\027\017\ \016 )Tj 0.051 Tw T* [(\023\031\021\036\n )0.5(\026\n\036\027\t \027\026\022\026 )0.5(\253/\273 \n\036\032\007\031 )0.5(\027\017\n\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\253\017/\017\035\017\273, )0.5(\004\021\024 )]TJ 0.25 Tw T* [(\023\024\n\024\032\036\021 \023\026\006\017\036\027\021\031 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 10.339 0 Td (\024\021\r\036\021\036 \027\026)Tj /Span<>> BDC ( )Tj EMC 4.607 0 Td (\r\024\023\030\024\f \024\021\007\036\035\034\027\024 )Tj 0.089 Tw -14.946 -1.218 Td (\031\004\017\021\t\r\026\021\034 \f\r\024\005 \024\023\t\021 \027\026\035\ \017\004\017\016 \022\026\022 \r\t\023\026\007\036\027\017\016 \206\211,\ \021\026\022 )Tj -0.038 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\013\031\013\036\027\017\016 \r\t\002\031\b\026\027\017\016, \017\035\ \017 \024\002\024\017\b \f\017\n\023\021\024\n\024\r \r\n\036\f\021\036.\ )Tj 0.077 Tw T* (\212\030\031\020\024\005 \023\030\017\004\017\027\024\005 \026\n\036\001\ \026\021\036\035\034\f\021\r\026 \016\r\017\035\024\f\034 \021\024, \004\ \021\024 \r\024 )Tj 0.042 Tw T* (\r\030\036\n\016 \030\026\002\024\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\024\n \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\022\024\021\024\030\t\b \030\036\f\023\024\027\007\036\027)Tj 0 Tw (-)Tj -0.009 Tw T* (\021\024\r \(2/10\) \r\024\027\017\022\026\035\026 \023\031\021\026\027\ \017\006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021\036, \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.211 Tw T* (\017\b \f\023\030\026\001\017\r\026\035\017: \004\026\f\021\034 \023\026\ \006\017\036\027\021\024\r \f\004\017\021\026\035\024, \004\021\024 \030\ \036\004\034 )Tj 0.068 Tw T* (\017\007\036\021 \024)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\024 \027\026\002\031\b\026\027\017\017, \022\ \024\021\024\030\024\036 \024\027\017 \024\013\031\013\026\033\021 )Tj 0.112 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034\023\017\030\024\r\026\027\017\017, \007\030\031\020\017\ \036 \032\036 \f\004\017\021\026\035\017, \004\021\024 \030\036\004\034 \ \024\002 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7776 56.0378 Tm (138)Tj ET endstream endobj 700 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \213\212\217\r)10(\025\b\025\221 \n\022\r\005\025\016\016-\r\002\020\200)21(\026)-19.9(\002\005\t\025\221 \b\017\020\n\202\017\n\n )]TJ 0 -1 TD [(\025\224\005\025\016\t\n\r\017 PRO)20(M-HIS)21(S \202)-21(\020\213 \224\017\n\004\t\026)11(\025\b \016\022\013)10(\004\024\025\005\005\025\004\024)]TJ 39.217 1 Td [(Results of\022linguistic and cr)20(oss-cultur)21(al v)10(alidation of\022th)11(e )]TJ 21.255 0 Td ( )Tj -25.84 -1 Td [(PRO)20(M-HIS)21(S questionnair)31.1(e for patients with h)11(emorrh)11(oidal disease)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.129 Tw 10 0 0 10 42.5197 724.8299 Tm (\r\022\035\033\004\017\r\001\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \007\r\031\b \023\030\036\007\f\021\026\r\017\021\036\035\ \036\005 \017\027\017\006\017\017\030\031)Tj 0 Tw (-)Tj 0.15 Tw 0 -1.218 TD (\033\013\036\005 \f\021\024\030\024\027\t \(\202\210 \253\222\036\030\r\034\ \036\273, \217\024\f\f\017\016\), \024\007\027\024\020\024 \023\030\026\022\ )Tj 0 Tw (-)Tj 0.324 Tw T* [(\021\017\022\031\033\013\036\020\024 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\026 \f)]TJ /Span<>> BDC ( )Tj EMC (\024\023\t\021\024\n \024\030\020\026\027\017\026\006\017\017 )Tj 0.608 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\016 \027\026\031\004\027\024-\017\f\f\ \035\036\007\024\r\026\021\036\035\034\f\022\024\005 \030\026\002\024\021\ \t )Tj 0.072 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.778 0 Td [(\220\021\024\005 )0.6(\024\002\035\026\f\021\017, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.737 0 Td [(\007\r\031\b )0.5(\023\036\030\036\r\024\007\004\017\022\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 9.037 0 Td (\020\024\035\035\026\027\007\f\022\024\020\024 )Tj -0.042 Tw -16.553 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005. \212\r\026 \027\036\026\r\017\f\017\n\t\b \023\ \036\030\036\r\024\007\004\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007)Tj 0 Tw (-)Tj 0.172 Tw 0 -1.218 TD (\f\022\024\020\024 \016\t\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \(\024\002\026 \024\002\035\026\007\026\035\017\ \007\035\017\021\036\035\034\027\t\n )Tj 0.175 Tw 0 -1.218 TD [(\024\023\t\021\024\n )0.5(\023\036\030\036\r\024\007\024\r )0.6(\n\036\007\017\006\017\027\f\022\017\b )0.6(\021\036\022\f\021\024\r )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 18.469 0 Td (\020\024\035\035\026\027\007)Tj 0 Tw (-)Tj 0.142 Tw -18.469 -1.218 Td (\f\022\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005\) \r\t\023\024\035\027\017\035\017 \023\030\016\ \n\024\005 \023\036\030\036\r\024\007 \024\030\017)Tj 0 Tw (-)Tj 0.292 Tw T* [(\020\017\027\026\035\034\027\024\005 )0.5(\r\036\030\f\017\017 \024\023\030\024\f\027\017\022\026, \023\030\036\f\035\ \036\007\031\016 )0.5(\024\f\027\024\r\027\024\005 )]TJ 0.2 Tw T* (\026\007\026\004\036\005 \n\026\022\f\017\n\026\035\034\027\024 \021\024\ \004\027\031\033 \021\036\022\f\021\024\r\031\033 \026\007\026\023\021\026\ \006\017\033 )Tj 0.172 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\023\021\031\026\035\034\027\t\n \023\036\030\036\027\ \024\f\024\n \f\n\t\f\035\024\r, \024\021\030\026\032\036\027\027\t\b )Tj 0.1 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\030\017\020\017\027\026\035\034\027\024\005 \r\036\030\f\017\017 \024\ \023\030\024\f\027\017\022\026 PROM-HIS)17(S, \r)]TJ /Span<>> BDC ( )Tj EMC (\036\020\024 )Tj 0.188 Tw 0 -1.218 TD (\030\031\f\f\022\024\016\t\004\027\031\033 \r\036\030\f\017\033. \217\036\ \031\035\034\021\026\021\024\n \007\026\027\027\024\020\024 \220\021\026\ \023\026 )Tj 0.291 Tw 0 -1.218 TD (\016\r\017\035\024\f\034 \f\024\007\026\027\017\036 \007\r\031\b \r\036\ \030\f\017\005 \023\030\016\n\024\020\024 \023\036\030\036\r\024\007\026\ : )Tj -0.012 Tw T* (\023\030\016\n\024\005 \023\036\030\036\r\024\007 \215\215)Tj /Span<>> BDC ( )Tj EMC (\227 1.1 \017)Tj /Span<>> BDC ( )Tj EMC (\215\215)Tj /Span<>> BDC ( )Tj EMC (\227 1.2, \022\024\021\024\030\t\036 \026\021\036\n )Tj -0.018 Tw T* (\002\t\035\017 \024\002\255\036\007\017\027\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\031\033 \r\036\030\f\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036. )Tj 0.063 Tw T* (\221\026\022 \032\036, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\r \024\030\017\020\017\027\026\035\034\027\024\n \024\023\030\024\f\027\ \017\022\036 PROM-HIS)17.1(S, )]TJ 0.236 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\031\f\f\022\024\016\t\004\027\024\005 \024\002\255\036\ \007\017\027\036\027\027\024\005 \r\036\030\f\017\017 \f\024\007\036\030\ )Tj 0 Tw (-)Tj 0.081 Tw T* (\032\026\035\024\f\034 \021\030\017 \007\024\n\036\027\026 \(\212\): 1\)\ )Tj /Span<>> BDC ( )Tj EMC (\222\017\n\023\021\024\n\t \020\036\n\024\030\030\024\016 \(\2121\), )Tj 0.238 Tw T* (2\))Tj /Span<>> BDC ( )Tj EMC (\200\035\017\016\027\017\036 \020\036\n\024\030\030\024\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\024\f\021\ \034 )Tj 0.119 Tw T* (\(\2122\) \017)Tj /Span<>> BDC ( )Tj EMC (3\))Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\036\027\027\024\f\021\034 \035\036\004\ \036\027\017\036\n \(\2123\). \2121 \f\024)Tj 0 Tw (-)Tj 0.019 Tw T* [(\007\036\030\032\026\035 \023\016\021\034 )0.5(\027\026\017\002\024\035\036\036 )0.5(\004\026\f\021\t\b \024\002\255\036\022\021\017\r\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\031\002\255\036\022)Tj 0 Tw (-)Tj 0.043 Tw T* [(\021\017\r\027\t\b \f\017\n\023\021\024\n\024\r \026\002\024\035\036\r\026\ \027\017\016, )0.5(\r\t\030\026\032\036\027\027\024\f\021\034 \022\024\021\024)]TJ 0 Tw (-)Tj -0.069 Tw T* (\030\t\b \023\026\006\017\036\027\021 \024\006\036\027\017\r\026\035 \023\ \024)Tj /Span<>> BDC ( )Tj EMC (5-\002\026\035\035\034\027\024\005 \001\022\026\035\036 \214\026\005\022\ \036\030\021\026, )Tj -0.046 Tw T* (\021\024\020\007\026 \022\026\022 \2122 \017)Tj /Span<>> BDC ( )Tj EMC (\2123 \r\022\035\033\004\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\n\031 \r\024\023\030\024\f\031, )Tj 0.037 Tw T* (\024\021\r\036\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\036 \023\030\036\007\023\024\035\026\020\026\035\024\ \f\034 \007\026\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026)Tj 0 Tw (-)Tj 0.017 Tw T* (\027\017\036\n 10-\002\026\035\035\034\027\024\005 \004\017\f\035\024\r\024\ \005 \001\022\026\035\t \024\006\036\027\022\017. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255)Tj 0 Tw (-)Tj 0.421 Tw T* (\036\007\017\027\036\027\017\017 \007\r\031\b \023\030\016\n\t\b \023\036\ \030\036\r\024\007\024\r \023\024\021\030\036\002\024\r\026\035\024\f\034\ )Tj 0.195 Tw T* (\024\002\f\031\032\007\036\027\017\036 \027\036\022\024\021\024\030\t\b \ \024\023\030\036\007\036\035\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004)Tj 0 Tw (-)Tj 0.225 Tw T* (\027\024\005 \r\036\030\f\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \022)Tj /Span<>> BDC ( )Tj EMC (\031\021\r\036\030\032\007\036\027\017\033 \021\024\020\024, \004\021\024\ )Tj 0.046 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \024\023\030\024\f\027\017\022\036 \027\036\021 \023\ \030\026\r\017\035\034\027\t\b \017\035\017 \027\036\023\030\026\r\017\035\ \034)Tj 0 Tw (-)Tj 0.065 Tw T* (\027\t\b \024\021\r\036\021\024\r \002\t\035\024 \030\036\001\036\027\024\ \007\024\002\026\r\017\021\034 \235\030\026\031 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 )Tj 0.009 Tw T* (\023\026\006\017\036\027\021\031 \023\030\036\007\035\026\020\026\036\021\ \f\016 \r\t\002\030\026\021\034 \021\024\021 \r\026\030\017\026\027\021,\ \022\024\021\024\030\t\005 )Tj 0.133 Tw T* (\253\027\026\017\002\024\035\036\036 \021\024\004\027\024 \024\021\030\026\ \032\026\036\021 \036\020\024 \f\024\f\021\024\016\027\017\036\273. \217\ \026\002\024\004\026\016 )Tj 0.082 Tw T* [(\020\030\031\023\023\026 )0.5(\023\024\f\004\017\021\026\035\026, )0.6(\004\021\024 )0.5(\021\026\022\024\036 )0.6(\007\024\002\026\r\035\036\027\017\036 )0.5(\027\026\023\030\026\r\035\036\027\024 )]TJ 0.144 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \016\f\027\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\022\024\036 \007\035\016 \030\024\f\f\017\005\f\022\024\020\ \024 \023\026\006\017\036\027\021\026 )Tj 0.024 Tw T* (\r\024\f\023\030\017\016\021\017\036 \026\007\026\004\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\033 \007\026\027\027\024\020\024 \024\023\ \030\024\f\027\017)Tj 0 Tw (-)Tj 0.157 Tw T* (\022\026. \212\026\035\036\036, \030\026\002\024\004\026\016 \020\030\031\ \023\023\026 \024\002\f\031\007\017\035\026 \r\024\027\017\022\001\017\036\ \023\024)Tj 0 Tw (-)Tj 0.131 Tw T* (\f\035\036 \023\036\030\036\r\024\007\026 \030\026\f\b\024\032\007\036\027\ \017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\017\016\b \f\021\036\023\036\027\017\ )Tj 0.18 Tw T* (\r\t\030\026\032\036\027\027\024\f\021\017 \f\017\n\023\021\024\n\024\r,\ \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\023\030\026\001\017\r\026\035\024\f\034 )Tj 0.127 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\2121. \202)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\027\027\024, \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f, \007\024\f\035\024\r\027\024 \023\036\030\036\r\024\ \007\016\013\017\005)Tj 0 Tw (-)Tj 0.108 Tw T* (\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \022\026\022 \253\200 \022\026\022\024\005 \f\021\ \036\023\036\027\017 \r\t \017\f\023\t\021\t\r\026\035\017 )Tj 0.076 Tw T* [(\023\030\017\r\036\007\201\027\027\t\036 )0.6(\027\017\032\036 )0.5(\032\026\035\024\002\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 13.109 0 Td [(\023\030\024\021\016\032\036\027\017\017 )0.6(\023\030\024\001\035\024\005 )]TJ 0.123 Tw -13.109 -1.218 Td (\027\036\007\036\035\017?\273 \r)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\f\017\017 \024\007\027\024\020\024 \023\036\030\036\r\024\007\ \004\017\022\026 \031\023\024\n\016\027\031\021\t\036 )Tj 0.1 Tw T* (\f\021\036\023\036\027\017 \002\t\035\017 \r\t\030\026\032\036\027\t \004\ \036\030\036 \022\026\004\036\f\021\r\036\027\027\t\036 \b\026\030\026\022\ )Tj 0 Tw (-)Tj 0.267 Tw T* (\021\036\030\017\f\021\017\022\017 \253\027\036\027\026\004\017\021\036\ \035\034\027\024\273, \253\031\n\036\030\036\027\027\024\273, \253\f\017\ \035\034\027\024\273, )Tj 0.111 Tw T* (\253\024\004\036\027\034 \f\017\035\034\027\024\273 \017\035\017 \253\024\ \021\f\031\021\f\021\r\024\r\026\035\017\273, \021\024\020\007\026 \022\026\ \022 \r\021\024)Tj 0 Tw (-)Tj 0.232 Tw T* (\030\024\005 \023\036\030\036\r\024\007\004\017\022 \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\021 \032\036 \r\024\023\030\024\f, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\036, )Tj 0.092 Tw T* (\023\030\036\007\024\f\021\026\r\017\035 \r\026\030\017\026\027\021\t \024\ \021\r\036\021\024\r \f\022\024\030\036\036 \031\022\026\t\r\026\033\013\ \017\b )Tj 0.185 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \017\b \r\024\027\017\022\027\024\r\036\027\017\ \016: \253\023\030\026\022\021\017\004\036\f\022\017 \027\017\022\024\020\ )Tj 0 Tw (-)Tj -0.042 Tw T* (\007\026\273, \253\024\004\036\027\034 \030\036\007\022\024\273, \253\030\ \036\007\022\024\273, \253\004\026\f\021\024\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\024\004\036\027\034 \004\026\f\021\024\273. )Tj 0.068 Tw T* [(\217\026\002\024\004\036\005 )0.5(\020\030\031\023\023\024\005 )0.6(\002\t\035\024 )0.5(\030\036\001\036\027\024 )0.5(\023\030\017\007\036\030\032\017\r\026\021\034\f\016 )0.6(\r\036\030)]TJ 0 Tw (-)Tj 0.125 Tw T* [(\f\017\017 )0.5(\023\036\030\036\r\024\007\026 )0.6(\023\036\030\r\024\020\024 )0.5(\023\036\030\036\r\024\007\004\017\022\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.235 0 Td [(\f\017\035\031 )0.5(\021\024\020\024, )0.6(\004\021\024 )]TJ -0.016 Tw 7.009 64.543 Td (\024\027\026 \n\026\022\f\017\n\026\035\034\027\024 \f\024\024\021\r\036\ \021\f\021\r\031\036\021 \027\026\004\036\027\017\016\n \024\023\030\036\ \007\036\035\036)Tj 0 Tw (-)Tj 0.078 Tw T* (\027\017\005, \017\f\023\024\035\034\024\r\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\005 \r\036\030\f\017\017 \024\ \023\030\024\f)Tj 0 Tw (-)Tj 0.309 Tw T* (\027\017\022\026, \026)Tj /Span<>> BDC ( )Tj EMC 3.684 0 Td [(\021\026\022\032\036 )0.5(\023\024\021\024\n\031, \004\021\024 \r\t\030\026\032\036\027\027\024\f\021\ \034 )0.6(\r\035\017\016\027\017\016 )]TJ 0.038 Tw -3.684 -1.218 Td (\031\022\026\026\027\027\t\b \f\017\n\023\021\024\n\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026 \035\031\004\001\036 \023\036\030\036\007\ \026\036\021\f\016 )Tj 0 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\n\017 \b\026\030\026\022\021\036\030\ \017\f\021\017\022\026\n\017.)Tj 0.294 Tw T* (\215\036\030\036\r\024\007\t \f\026\n\017\b \f\017\n\023\021\024\n\024\r\ , \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\023\030\026\001\017\r\026)Tj 0 Tw (-)Tj -0.008 Tw 0 -1.218 TD (\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\2121 \021\026\022\032\036 \023\024\021\030\036\002\024\r\026\035\017 \024\ \002\f\031\032\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\016\021\017\016 )Tj 0.268 Tw 0 -1.218 TD [(\022\024\027\f\036\027\f\031\f\027\024\020\024 \030\036\001\036\027\017\016\ )0.5(\024\002 \024\022\024\027\004\026\021\036\035\034\027\024\005 \r\036\030\ \f\017\017. )]TJ 0.201 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \002\t\035\024 \030\036\001\036\027\024\ , \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\026\b \024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b )Tj 0.174 Tw T* (\f\017\n\023\021\024\n\026\b, \022\026\022 \253\207\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\027\031\f\026\273, \253\003\031\007 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002)Tj 0 Tw (-)Tj 0.047 Tw T* (\035\026\f\021\017 \026\027\031\f\026\273 \017\035\017 \253\200\024\007\016\ \027\017\f\021\t\036 \r\t\007\036\035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\031\f\026\273, )Tj 0.022 Tw T* (\023\030\036\007\f\021\026\r\035\016\033\013\017\b \007\024\f\035\024\r\027\ \t\005 \023\036\030\036\r\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024, )Tj 0.126 Tw 0 -1.218 TD (\002\024\035\036\036 \023\024\007\b\024\007\016\013\017\n \007\035\016 \030\ \024\f\f\017\005\f\022\024\020\024 \023\026\006\017\036\027\021\026 \002\ \031\007\036\021 )Tj 0.133 Tw 0 -1.218 TD (\026\n\036\027\026 \f\035\024\r\026 \253\026\027\031\f\273 \027\026)Tj /Span<>> BDC ( )Tj EMC (\253\026\007\027\017\005 \023\030\024\b\024\007\273. \200)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024)Tj 0 Tw (-)Tj 0.035 Tw 0 -1.218 TD (\f\036, \024\023\017\f\t\r\026\033\013\036\n \027\026\035\017\004\017\036\ \r\t\023\026\007\036\027\017\016 \017\035\017 \027\026\002\031\b\026\027\ \017\016 )Tj 0.277 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\007\027\036\020\024 \023\030\024\b\024\007\ \026, \007\024\f\035\024\r\027\024: \253\210\013\031\013\036\027\017\036\ )Tj 0.171 Tw T* [(\r\t\023\016\004\017\r\026\027\017\016/\023\030\017\023\031\b\035\024\f\021\ \017 )0.7(\026\027\031\f\026\273, )0.5(\030\026\002\024\004\036\005 )0.5(\020\030\031\023\023\024\005 )]TJ T* (\002\t\035\024 \030\036\001\036\027\024, \004\021\024 \n\026\022\f\017\n\ \026\035\034\027\024 \007\024\f\035\024\r\027\t\005 \023\036\030\036\r\024\ \007 )Tj 0.093 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024 \027\036 \023\024\r\024\035\ \017\021 \024\021\030\026\017\021\034 \f\n\t\f\035 \f\017\n\023\021\024\ )Tj 0 Tw (-)Tj 0.064 Tw T* (\n\024\r, \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \f\023\030\026\001\017\r\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\031 \021\024\020\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024)Tj 0 Tw (-)Tj 0.077 Tw T* (\235\036\f\f\017\024\027\026\035\034\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\f\022\024\n \f\024\024\002\013\036\f\021\r\026\ \b \217\205 \031\023\024)Tj 0 Tw (-)Tj 0.241 Tw T* (\021\030\036\002\035\016\036\021\f\016 \007\030\031\020\026\016 \021\036\ \030\n\017\027\024\035\024\020\017\016. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \f\035\031\004\026\036 )Tj -0.027 Tw T* (\002\t\035\024 \030\036\001\036\027\024 \024\021\024\005\021\017 \024\021\ \007\024\f\035\024\r\027\024\020\024 \023\036\030\036\r\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024)Tj 0 Tw (-)Tj -0.003 Tw T* (\027\031 \002\024\035\036\036 \022\024\027\006\036\023\021\031\026\035\034\ \027\024\020\024, \022\024\021\024\030\t\005 \023\024\r\024\035\016\036\ \021 \f\024\b\030\026)Tj 0 Tw (-)Tj 0.011 Tw T* (\027\017\021\034 \022\026\022 \f\n\t\f\035, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\034 \024\030\017\020\017\027\026\035\034\027\024\ \020\024 \r\024\023\030\024)Tj 0 Tw (-)Tj 0.13 Tw T* [(\f\026: \253\200\t\023\026\007\036\027\017\036 \020\036\n\024\030\030\024\ \017\007\026\035\034\027\t\b )0.5(\031\035\024\r /\024\013\031\013\036\027\017\036 )]TJ 0 Tw T* (\027\026\002\031\b\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \026\007\027\036\020\024 \023\030\024\b\024\007\ \026\273.)Tj 0.041 Tw T* (\200 \r\024\023\030\024\f\036 \2122 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \027\026\f\022\024\035\034\022\024 \023\036\030\036\004\017\f\ \035\036\027\027\t\036 \f\017\n\023)Tj 0 Tw (-)Tj 0.214 Tw T* (\021\024\n\t \r\035\017\016\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \023\024\r\f\036\007\027\036\r\027\024\005 \ \032\017\027\017 \023\026)Tj 0 Tw (-)Tj 0.314 Tw T* (\006\017\036\027\021\024\r, \007\017\f\022\031\f\f\017\016 \r\024\027\017\ \022\035\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \023\036\030\036\r\024\007\026 )Tj 0.273 Tw T* [(\023\030\024\017\r\024\007\027\024\020\024 \024\021 \020\024\035\035\026\ \027\007\f\022\024\020\024 \020\035\026\020\024\035\026 \253gehindr)-24(e\273, )]TJ 0.137 Tw T* (\007\024\f\035\024\r\027\024 \023\036\030\036\r\024\007\016\013\036\020\024\ \f\016 \022\026\022 \253\n\036\001\026\021\034 \004\036\n\031-\035\017\002\ \024\273. )Tj 0.194 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\f\017\017 \024\007\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\004\017\022\024\r, \f\024\007\036\030\032\026\ \035\f\016 \007\024)Tj 0 Tw (-)Tj 0.073 Tw T* (\f\035\024\r\027\t\005 \023\036\030\036\r\024\007 \031\022\026\026\027\027\ \024\020\024 \020\035\026\020\024\035\026, \021\024\020\007\026 \022\026\ \022 \007\030\031)Tj 0 Tw (-)Tj 0.109 Tw T* [(\020\024\005 \023\036\030\036\r\036\035 )0.5(\036\020\024 \022\026\022 \253\026\021\030\031\007\027\016\021\034 )0.5(\004\021\024-\035\017\002\024\273. )0.5(\217\036\001\036\027\024 )]TJ 0.049 Tw T* (\017\f\023\024\035\034\024\r\026\021\034 \020\035\026\020\024\035 \253\ \026\021\030\031\007\027\016\021\034\273, \021\026\022 \022\026\022 \024\ \027 \027\026\017\002\024)Tj 0 Tw (-)Tj 0.031 Tw T* (\035\036\036 \023\024\027\016\021\036\027 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\n\t\f\035\031 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\036 \024)Tj /Span<>> BDC ( )Tj EMC (\r\035\017\016\027\017\017 \f\017\n\023)Tj 0 Tw (-)Tj 0.103 Tw T* (\021\024\n\024\r \002\024\035\036\027\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\036 \026\f\023\036\022\021\t \023\024\r\f\036\ \007\027\036\r\027\024\005 )Tj 0.305 Tw T* [(\032\017\027\017. )0.5(\221\026\022\032\036, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\024\002\f\031\032\007\036\027\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\002\024\004\036\005 )0.5(\020\030\031\023\023\036 )]TJ 0.284 Tw T* [(\023\036\030\036\r\024\007\024\r \007\r\031\b \023\024\035\016\030\027\t\ \b \f\021\036\023\036\027\036\005 )0.5(\r\t\030\026\032\036\027\027\024\f\021\017 )]TJ 0.435 Tw T* (\031\023\024\n\016\027\031\021\024\020\024 \253\026\021\030\031\007\027\ \036\027\017\016\273, \022\024\021\024\030\t\036 \017\f\023\024\035\034\ \031\033\021)Tj 0 Tw (-)Tj 0.122 Tw T* (\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 \214\026\005\022\036\030\021\026, \002\t\035\024 \030\ \036\001\036\027\024 \023\030\017\007\036\030\032\017\r\026\021\034\f\016\ )Tj -0.002 Tw T* (\r\036\030\f\017\005 \253\f\024\r\036\030\001\036\027\027\024 \027\036 \ \026\021\030\031\007\027\016\035\017\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\022\030\026\005\027\036 \f\017\035\034)Tj 0 Tw (-)Tj 0.332 Tw T* [(\027\024 )0.5(\026\021\030\031\007\027\016\035\017\273 )0.6(\r\n\036\f\021\024 )0.5(\253\023\030\026\022\021\017\004\036\f\022\017 )0.6(\027\036 )0.5(\n\036\001\026\035\017\273 )]TJ -0.012 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\253\024\004\036\027\034 \n\036\001\026\035\017\273 \r)Tj /Span<>> BDC ( )Tj EMC (\f\017\035\031 \030\026\027\036\036 \031\023\024\n\016\027\031\021\024\005\ \023\030\017\004\017\027\t.)Tj -0.066 Tw T* (\212\017\f\022\031\f\f\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\031 \r\024\023\030\024\f\026 \2123, \022\026\f\ \026\033\013\036\020\024\f\016 \023\030\024)Tj 0 Tw (-)Tj 0.321 Tw T* [(\b\024\032\007\036\027\017\016 )0.6(\024\023\030\026\001\017\r\026\036\n\t\n )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.6(\035\036\004\036\027\017\016, )]TJ 0.21 Tw T* (\022\024\f\027\031\035\026\f\034 \027\036\024\002\b\024\007\017\n\024\f\021\ \017 \024\021\024\005\021\017 \024\021 \023\030\016\n\024\020\024 \023\036\ \030\036)Tj 0 Tw (-)Tj 0.104 Tw T* [(\r\024\007\026 )0.5(\027\026\r\026\027\017\005 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b )0.6(\r\n\036\001\026\021\036\035\034\f\021\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.238 0 Td (\024\030\017)Tj 0 Tw (-)Tj 0.017 Tw -20.238 -1.218 Td (\020\017\027\026\035\034\027\024\020\024 \024\023\030\024\f\027\017\022\026\ , \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \002\024\035\036\036 \031\021\024\004\027\036\ \027\027\024\020\024. )Tj -0.036 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \r\n\036\f\021\024 \024\002\013\036\020\ \024 \024\023\030\036\007\036\035\036\027\017\016 \253\024\023\036\030\026\ \006\017\016\273, )Tj 0.087 Tw T* (\004\021\024, \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\027\036\027\017\033 \022\024\035\024\023\030\024\022\021\024\035\024\020\ \026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \023\030\036\007\f\021\026\r\017\021\036)Tj 0 Tw (-)Tj -0.044 Tw T* (\035\036\005 \017\027\017\006\017\017\030\031\033\013\036\005 \f\021\024\ \030\024\027\t, \r\b\024\007\016\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r \030\026\002\024)Tj 0 Tw (-)Tj -0.035 Tw T* (\004\036\005 \020\030\031\023\023\t, \002\031\007\036\021 \007\035\016 \030\ \024\f\f\017\005\f\022\024\020\024 \023\026\006\017\036\027\021\026 \016\ \r\035\016\021\034\f\016 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_2 1 Tf 25 0 0 25 505.5395 56.0378 Tm (137)Tj ET endstream endobj 699 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.159 Tw 10 0 0 10 70.8661 724.8299 Tm (\212\026\035\036\036 \r\t\023\024\035\027\016\035\024\f\034 \024\002\255\ \036\007\017\027\036\027\017\036 \023\024\035\031\004\036\027\027\t\b \023\ \036\030\036)Tj 0 Tw (-)Tj 0.125 Tw 0 -1.218 TD (\r\024\007\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\031 \r\036\030\f\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \f\024\020\035\026\f\024\r\026\027\017\036. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017)Tj 0 Tw (-)Tj 0.259 Tw T* (\004\017\017 \022\026\022\017\b-\035\017\002\024 \016\t\022\024\r\t\b \017\ \035\017 \f\n\t\f\035\024\r\t\b \030\026\f\b\024\032)Tj 0 Tw (-)Tj 0.384 Tw T* [(\007\036\027\017\005, )0.6(\030\026\002\024\004\026\016 )0.5(\020\030\031\023\023\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 11.792 0 Td [(\f\024\f\021\026\r\036 )0.5(\023\030\036\007\f\021\026\r\017\021\036\035\036\005 )]TJ 0.153 Tw -11.792 -1.218 Td (\202\210)Tj /Span<>> BDC ( )Tj EMC (\253\222\036\030\r\034\036\273, \f\023\036\006\017\026\035\017\f\021\026\ \007\030\026\r\024\024\b\030\026\027\036\027\017\016 \f\024 \f\023\036\ )Tj 0 Tw (-)Tj 0.153 Tw T* [(\006\017\026\035\017\026\006\017\036\005 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\004\017\022\026\(\024\r\) )Tj 0.058 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024, \024\002\f\031\032\007\026\ \035\017 \017\n\036\033\013\017\036\f\016 \030\026\f\b\024\032\007\036\027\ \017\016 )Tj 0.104 Tw 0 -1.218 TD (\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\021\024\020\036 \f\235\024\030\n\017\030\024\r\026\035\017 \024\002\ \255\036\007\017\027\036\027\027\031\033 \f\024\020\035\026\f\024\r\026\027\ )Tj 0 Tw (-)Tj 0.079 Tw T* [(\027\031\033 \r\036\030\f\017\033 \024\023\030\024\f\027\017\022\026 \(\210\ \222\200\) PROM-HIS)17.1(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n )Tj 0 Tw T* (\016\t\022\036.)Tj -0.033 Tw T* (\215\024\f\035\036 \021\024\020\024, \022\026\022 \210\222\200 \002\t\035\ \026 \f\235\024\030\n\017\030\024\r\026\027\026, \r\t\023\024\035\027\036\ \027 \036\036 )Tj 0 Tw T* (\024\002\030\026\021\027\t\005 \023\036\030\036\r\024\007.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 554.3378 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.007 Tw 10 0 0 10 70.8661 529.9818 Tm (\037\036\035\034\033 \220\021\024\020\024 \220\021\026\023\026 \016\r\035\ \016\035\024\f\034 \024\f\031\013\036\f\021\r\035\036\027\017\036 \022\024\ \027\021\030\024\035\016 )Tj 0.179 Tw T* (\022\026\004\036\f\021\r\026 \023\036\030\036\r\024\007\026, \004\021\024\ \023\024\r\024\035\017\035\024 \023\030\017\005\021\017 \022)Tj /Span<>> BDC ( )Tj EMC (\026\022\035\033)Tj 0 Tw (-)Tj 0.188 Tw T* (\004\036\027\017\033: \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\030\026\021\027\024\n \023\036\030\036\r\024\007\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\026\030\020\036\021\027\024\020\024 \016\t\022\026 )Tj 0.307 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\t\005 \f\n\t\f\035 \017\f\b\024\ \007\027\024\020\024 \024\023\030\024\f\027\017\022\026 \f\024)Tj 0 Tw (-)Tj 0.16 Tw T* (\b\030\026\027\016\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \024\002\255\036\n\036. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\f\r\024\036\005 \f\031\021\017 )0.5(\007\026\027\027\t\005 )]TJ 0.067 Tw T* (\220\021\026\023 \r\t\023\024\035\027\036\027 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\022\031\f\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\f\035\024\r\027\t\005 \(\027\036 \022\024\027\006\036\023)Tj 0 Tw (-)Tj 0.129 Tw T* (\021\031\026\035\034\027\t\005\) \023\036\030\036\r\024\007, \024\007\027\ \026\022\024 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\b \r\024\023\030\024\f\026\b, \022\024\021\024\030\t\036 )Tj 0.145 Tw T* (\024\021\027\024\f\016\021\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \f\031\002\255\036\022\021\017\r\027\t\n \021\036\n\ \026\n \(\031\007\024\r\035\036\021\r\024)Tj 0 Tw (-)Tj 0.333 Tw T* (\030\201\027\027\024\f\021\034 \023\030\024\r\036\007\036\027\027\t\n \035\ \036\004\036\027\017\036\n\), \023\036\030\036\r\024\007 \n\024\032\036\021\ )Tj 0.342 Tw T* (\002\t\021\034 \f\022\024\030\036\036 \022\024\027\006\036\023\021\031\026\ \035\034\027\t\n. \212\035\016 \027\036\024\002\b\024\007\017\n\024\f\021\ \017 )Tj 0.213 Tw T* [(\030\026\030\036\001\036\027\017\016 \r\t\016\r\035\036\027\027\t\b )0.5(\030\026\027\024\004\021\036\027\017\005 \r)]TJ /Span<>> BDC ( )Tj EMC (\021\030\026\022\021\024\r\022\026\b )Tj -0.015 Tw T* [(\023\036\030\036\r\036\007\036\027\027\024\020\024 )0.6(\021\036\022\f\021\026 )0.5(\002\t\035 )0.5(\007\024\f\021\017\020\027\031\021 )0.6(\022\024\027\f\036\027\f\031\f )0.5(\023\031\021\036\n )]TJ -0.019 Tw T* (\024\002\f\031\032\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\001\036\027\017\016 \f\023\024\030\027\t\b \n\036\f\021 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\r\024\007\036 \004\035\036)Tj 0 Tw (-)Tj 0.046 Tw T* (\027\026\n\017 \030\026\002\024\004\036\005 \020\030\031\023\023\t. \215\ \024)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \007\026\027\027\024\020\024 \220\ \021\026\023\026 )Tj 0.068 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\210\222\200 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036 \002\t\035\017 \r\027\036\f\036\027\ \t \027\036\024\002\b\024\007\017\n\t\036 )Tj 0.165 Tw T* (\023\024\023\030\026\r\022\017. \213\f\035\017 \021\026\022\024\r\024\005\ \023\024\021\030\036\002\027\024\f\021\017 \027\036 \r\024\027\017\022\ \026\035\024, )Tj 0.084 Tw T* (\021\024 \210\222\200 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036, \f\024\007\026\027\027\026\016 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\t\007\031\013\036\n )Tj 0.113 Tw T* [(\220\021\026\023\036, )0.6(\f\004\017\021\026\035\026\f\034 )0.5(\024\022\024\027\004\026\021\036\035\034\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 14.619 0 Td [(\002\t\035\026 )0.5(\r\016\021\026 )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 6.202 0 Td (\024\f)Tj 0 Tw (-)Tj -20.821 -1.218 Td (\027\024\r\031 \007\035\016 \022\024\020\027\017\021\017\r\027\024\020\024\ \017\027\021\036\030\r\034\033.)Tj 0.346 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \024\022\024\027\004\026\021\ \036\035\034\027\t\n \030\036\031\035\034\021\026\021\024\n \220\021\026\ \023\026 )Tj -0.011 Tw T* (\016\t\022\024\r\024\020\024 \023\036\030\036\r\024\007\026 \f\021\026\035\ \026 \f\024\007\026\027\027\026\016 \235\017\027\026\035\034\027\026\016\ \r\036\030)Tj 0 Tw (-)Tj 0.105 Tw T* [(\f\017\016 \024\023\030\024\f\027\017\022\026 PROM-HIS)17.1(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\n \016\t\022\036 \(PROM-)Tj 0.152 Tw T* [(HIS)17(S_R)12(U\), \022\024\021\024\030\026\016 \017\f\023\024\035\034\024\r\026\035\026\ \f\034 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\036\n )Tj 0 Tw T* (\220\021\026\023\036 \022\030\024\f\f-\022\031\035\034\021\031\030\027\024\ \005 \023\030\024\r\036\030\022\017.)Tj /T1_2 1 Tf 0.186 Tw 0 -2.436 TD [(\021\006\002\217\217-\220\210\f\001\003\210\006\b\004\235 )0.6(\212\006\002\r\006\220\004 )0.6(\(\004\f\t\240\004\204\t\235\) )0.5(\006\210\217\217\220\002)]TJ /Span<>> BDC (-)Tj EMC 0 Tw 0 -1.218 TD (\235\213\013\201\b\002\005 \r\006\217\t\t)Tj /T1_0 1 Tf 0.049 Tw T* (\212\026\027\027\t\005 \220\021\026\023 \r\026\035\017\007\026\006\017\017\ \r\t\023\024\035\027\036\027 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\030\024\r\036\030\022\017 )Tj -0.08 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\016\021\027\024\f\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\021\031 \026\007\026\r\026\036\n\t\b \r\024\023\030\ \024\f\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007)Tj 0 Tw (-)Tj 0.08 Tw T* (\035\026\020\026\036\n\t\b \022)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\031 \024\021\r\036\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\024\016\t\004\027\024\005 \r\036\030\f\017\017 )Tj 0.098 Tw T* [(\024\023\030\024\f\027\017\022\026 PROM-HIS)17.1(S_R)12(U. \221\026\022\017\n \024\002\030\026\024\n, \023\030\017\036\n\035\036\ )]TJ 0 Tw (-)Tj 0.107 Tw T* [(\n\024\f\021\034 )0.5(\007\035\016 )0.5(\006\036\035\036\r\024\005 )0.5(\023\024\023\031\035\016\006\017\017 )0.5(\023\036\030\036\r\036\007\036\027\027\024\005 )0.6(\r\036\030\f\017\017 )]TJ 0.154 Tw T* (\002\t\035\026 \023\030\024\r\036\030\036\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\021\r\036\030\032\007\036\027\026, \004\021\024 \002\t\035\024\ \027\036\024\002\b\024)Tj 0 Tw (-)Tj 0.029 Tw T* (\007\017\n\024 \007\035\016 \021\024\020\024, \004\021\024\002\t \031\002\ \036\007\017\021\034\f\016, \004\021\024 \023\030\036\007\023\024\035\026\ \020\026\036\n\t\005 )Tj 0.15 Tw T* [(\f\n\t\f\035 \024\023\030\024\f\027\017\022\026 PROM-HIS)17(S )0.5(\027\036 \002\t\035 \017\f\022\026\032\201\027 )0.5(\023\036\030\036)]TJ 0 Tw (-)Tj 0.017 Tw T* (\r\024\007\024\n. \230\027\021\036\030\r\034\033 \f)Tj /Span<>> BDC ( )Tj EMC (\026\n\002\031\035\026\021\024\030\027\t\n\017 \023\026\006\017\036\027\021\ \026\n\017, \017\n\036)Tj 0 Tw (-)Tj 0.032 Tw T* (\033\013\017\n\017 \030\026\035\017\004\027\t\036 \f\021\036\023\036\027\ \034 \021\016\032\036\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\016\r\035\036\027\017\016 \020\036)Tj 0 Tw (-)Tj -0.047 Tw T* (\n\024\030\030\024\017\007\026\035\034\027\024\005 \002\024\035\036\027\ \017, \023\030\024\r\024\007\017\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.253 Tw 23.244 64.543 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\006\017\023\024\n \253\022\024\020\027\017\021\017\r\027\ \024\020\024 \017\027\021\036\030\r\034\033\273, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n )Tj 0.119 Tw 0 -1.218 TD (\024\006\036\027\017\r\026\035\024\f\034 \023\024\027\017\n\026\027\017\036\ \022\026\032\007\t\n \031\004\026\f\021\027\017\022\024\n \r\024\023\030\ \024)Tj 0 Tw (-)Tj 0.089 Tw 0 -1.218 TD (\f\024\r, \f\024\007\036\030\032\026\013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\024\f\027\017\022\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\035\026\020\026\036\n\t\b \r\026)Tj 0 Tw (-)Tj 0.09 Tw 0 -1.218 TD (\030\017\026\027\021\024\r \024\021\r\036\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\017\b. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\017 \024\023\030\024\f\027\017\022\026\ )Tj -0.014 Tw 0 -1.218 TD (\031\004\026\f\021\027\017\022\026\n \002\t\035\024 \023\030\036\007\035\ \024\032\036\027\024 \253\007\031\n\026\021\034 \r\f\035\031\b\273, \021\ \026\022 \022\026\022 )Tj 0.07 Tw 0 -1.218 TD (\220\021\024 \023\024\r\024\035\016\036\021 \007\036\035\026\021\034 \n\ \t\f\035\017\021\036\035\034\027\t\036 \023\030\024\006\036\f\f\t \002\024\ \035\036\036 )Tj 0 Tw 0 -1.218 TD (\016\r\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\027\016\021\027\t\n\017.)Tj /T1_2 1 Tf 0 -2.436 TD (\222\201\004\217\003\b\t\220\t \t\b\003\r\006\001\211)Tj /T1_0 1 Tf -0.013 Tw 0 -1.218 TD (\212\035\016 \022\024\020\027\017\021\017\r\027\024\020\024 \017\027\021\ \036\030\r\034\033 \023\035\026\027\017\030\024\r\026\035\024\f\034 \023\ \030\017\r\035\036\004\034 )Tj 0.122 Tw T* (\024\021 5 \007\024)Tj /Span<>> BDC ( )Tj EMC (10 \004\036\035\024\r\036\022 \f\021\026\030\001\036 18 \035\036\021, \f\ )Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\035\036\027\027\t\n )Tj 0.111 Tw T* [(\007\017\026\020\027\024\024\n \020\036\n\024\030\030\024\016 I-IV \f\021\ \026\007\017\017 \(Gol)-31(igher\), \f)]TJ /Span<>> BDC ( )Tj EMC (\007\024\f\021\026)Tj 0 Tw (-)Tj 0.112 Tw T* (\021\024\004\027\t\n \023\024\027\017\n\026\027\017\036\n \022\026\022 \031\ \f\021\027\024\020\024, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\017\f\034\n\036\027\027\024\020\024 )Tj 0.071 Tw T* (\030\031\f\f\022\024\020\024 \016\t\022\026. \215\024\007\023\017\f\026\ \027\027\024\036 \017\027\235\024\030\n\017\030\024\r\026\027\027\024\036\ \f\024)Tj 0 Tw (-)Tj 0.294 Tw T* (\020\035\026\f\017\036 \023\026\006\017\036\027\021\026 \016\r\035\016\035\ \024\f\034 \024\002\016\026\021\036\035\034\027\t\n \031\f\035\024\r\017\ \036\n )Tj 0 Tw T* (\031\004\026\f\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\r\034\033.)Tj 0.119 Tw T* [(\213\f\035\017 )0.5(\r\024 )0.5(\r\030\036\n\016 )0.6(\022\024\020\027\017\021\017\r\027\024\020\024 )0.5(\017\027\021\036\030\r\034\033\017\030\024\r\026\027\017\016 )0.7(\r\t)]TJ 0 Tw (-)Tj 0.26 Tw T* [(\016\r\035\016\035\017\f\034 \023\024\021\030\036\002\027\024\f\021\017 \ )0.5(\r\024 \r\027\036\f\036\027\017\017 \017\n\036\027\036\027\017\005/\007\ \024)]TJ 0 Tw (-)Tj 0.343 Tw T* (\023\024\035\027\036\027\017\005/\031\021\024\004\027\036\027\017\005 \r\ )Tj /Span<>> BDC ( )Tj EMC (\235\017\027\026\035\034\027\031\033 \r\036\030\f\017\033 \024\023\030\024\ \f)Tj 0 Tw (-)Tj 0.081 Tw T* (\027\017\022\026, \007\026\027\027\026\016 \027\036\024\002\b\024\007\017\ \n\024\f\021\034 \024\002\f\031\032\007\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\002\024\004\036\005 )Tj 0.103 Tw T* (\020\030\031\023\023\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\016\021\017\036\n \022\024\027\f\036\027\f\031\f\026 \024\ )Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\f\024\024\002\030\026\027\024\f\021\017 )Tj 0.277 Tw T* (\017\n\036\027\036\027\017\016. \217\036\031\035\034\021\026\021\024\n\ \024\002\f\031\032\007\036\027\017\016 \016\r\035\016\035\026\f\034 \235\ \017)Tj 0 Tw (-)Tj 0.55 Tw T* (\027\026\035\034\027\026\016 \007\024\030\026\002\024\021\026\027\027\026\ \016 \r\036\030\f\017\016 \024\023\030\024\f\027\017\022\026 PROM-)Tj 0.254 Tw T* [(HIS)17(S_R)12(U, )0.5(\022\024\021\024\030\026\016 )0.6(\007\024\035\032\027\026 )0.5(\002\t\035\026 )0.5(\002\t\021\034 )0.6(\f\024\023\024\f\021\026\r\035\036\027\026 )]TJ 0.244 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\030\017\020\017\027\026\035\034\027\024\005 \r\036\030\f\017\036\005\ \024\023\030\024\f\027\017\022\026, \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\020\035\026\f\024\r\026\027)Tj 0 Tw (-)Tj 0.141 Tw T* (\027\024\f\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \024\002\036 \r\036\030\f\017\017 \022\024\027\006\ 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v)10(alidation of\022th)11(e )]TJ 21.255 0 Td ( )Tj -25.84 -1 Td [(PRO)20(M-HIS)21(S questionnair)31.1(e for patients with h)11(emorrh)11(oidal disease)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 615.9841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 615.9841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 578.7763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 578.7763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 524.7071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.01 Tw 9 0 0 9 90.7087 730.4919 Tm [(RESUL)30(T)-10(S: )0.6(the translated )0.5(v)13(ersion, )0.6(P)66(R)19(OM-HISS_R)27(U)47(, )0.5(has )0.5(good )0.5(e)-15(xter)-13.9(nal )0.5(and )0.5(content )0.5(v)16(alidity )0.5(and )0.5(adeq)14(uately )0.5(ref)-22(lects the )]TJ -0.005 Tw 0 -1.111 TD [(haemor)-15.9(rhoids sym)16(p)13(toms, )0.5(their im)16.1(pact on q)14(uality )0.5(of life, )0.5(and treatment )0.5(satisfaction. 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Linnik are full-time em)16(plo)12(yees of)]TJ /Span<>> BDC ( )Tj EMC [(the JSC \244Ser)-41.9(vier\245)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 0.005 -1.909 Td [(A)29(CKN)21(O)15(WLEDGEMENTS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 9.462 0 Td ( The)Tj /Span<>> BDC ( )Tj EMC [(authors w)12(ould lik)17(e to)]TJ /Span<>> BDC ( )Tj EMC (thank the)Tj /Span<>> BDC ( )Tj EMC [(TREN)22(C)14(H INSIGHT)-9.9(S ag)12(ency for conducting cognitiv)13(e inter)-41.9(vie)10(ws)]TJ /T1_2 1 Tf 0.037 Tc 0.313 Tw -9.462 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.5(T)45.4(A)37.5(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.322 Tw 6.758 0 Td [( S)-10.3(h)-15.1(e)-18(l)-8.3(y)-17.2(g)-28.9(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(Y)12.6(u)-9(.)-23.9(A)-23(.)-23.5(, K)-11.2(o)-15.8(s)-29.3(t)-36.8(a)-10.2(r)-19.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.3(.)40.6(V)39.7(.)-23.5(, K)12.1(v)-28.4(a)-26.6(s)-6.6(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(B)3.3(.B)3.3(.)-23.5(, L)-12.2(i)-3.2(n)-5.7(n)-14(i)-6.6(k O)11.4(.)-28.6(Z)-19.6(h)-5.1(. R)-6.7(e)-22.8(s)-8.8(u)-8.4(l)-15.4(t)-48.9(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(l)-16.7(i)-3.2(n)-11.9(g)-9.5(u)-13(i)-7.4(s)-29.3(t)-46.2(i)-5(c a)-7.6(n)-14.5(d c)-22.3(r)-15.8(o)-15.8(s)-22.2(s)-12.7(-)-28.6(c)-12.1(u)-8.4(l)-15.4(t)-22.3(u)-7.6(r)-30.8(a)-11.4(l v)-28.4(a)-11.4(l)-16.7(i)-8.8(d)-9.3(a)]TJ 0 Tc 0 Tw 49.578 0 Td (-)Tj 0.023 Tc 0.153 Tw -56.341 -1.2 Td [(t)-46.2(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e P)-1.9(R)-9.8(O)-6.5(M)-15.6(-)-12.5(H)-2.8(I)-35.5(S)-24.8(S q)-16(u)-12.5(e)-22.8(s)-29.3(t)-46.2(i)-6.8(o)-9.2(n)-5.7(n)-7.8(a)-14.9(i)-6(r)-19.1(e f)-25.2(o)-11.8(r p)-20(a)-18.2(t)-46.2(i)-10.9(e)-11.6(n)-17.3(t)-48.8(s w)-45.7(i)-15.8(t)-26.1(h h)-15.1(e)-11.5(m)-12.4(o)-11.8(r)-40.5(r)-28.4(h)-10.9(o)-12.5(i)-8.8(d)-9.3(a)-11.4(l d)-15.8(i)-7.4(s)-22.9(e)-13(a)-26.6(s)-22.9(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw [(K)14(ol)3.6(op)2.4(r)3.1(o)3.5(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.8(a)5.8(.)]TJ /T1_3 1 Tf 0.013 Tc 0.163 Tw 42.348 0 Td [( 2)-18.9(0)-13.8(2)-5.8(6)9.9(;2)-11.4(5)-9.1(\()27.7(1)34.3(\))4.5(:)11(1)-17.9(3)-29.3(4)-34.7(\226)40.9(1)2.5(4)30.1(1)-5.8(.)-10.3( \()-10.9(i)-13.2(n)-10.3( R)-16.5(u)-31.9(s)-32.3(s)-25.5(.)33.3(\).)13( )]TJ -0.032 Tc 0.032 Tw -42.348 -1.2 Td [(h)-72.2(t)-104.4(t)-84.4(p)-73.7(s)-62.9(:)-53.1(/)29.7(/)-18.6(d)-66.1(o)-67.5(i)-55.2(.)-52.3(o)-66.8(r)-71.7(g)-77.8(/)-43.7(1)-41(0)-48.5(.)-60.6(3)-47.1(3)-70.9(8)-53.7(7)-50.4(8)-55(/)-47.1(2)-63.9(0)-45.7(7)-56.9(3)-68.3(-)-13.8(7)-44.3(5)-54.6(5)-63.9(6)-81.7(-)-45.2(2)-63.9(0)-58.8(2)-50.8(6)-81.7(-)-45.3(2)-56.4(5)-78.5(-1)-28.1(-1)-62.9(3)-74.2(4)-83.5(-1)-42.4(4)-14.9(1)]TJ /T1_2 1 Tf 0.01 Tc -0.006 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc -0.001 Tw 10.529 0 Td ( \035\022\025\025\022\n \217\f\017\b\020 \234\020\025\031\021\025\020, \003\ \217 \253\205\027\032\021\017\027\273, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\035\027\024\025\020\t, \030.)Tj /Span<>> BDC ( )Tj EMC (7, \215\031\024\n\021\020, 125196, \206\031\024\024\022\t; \023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(915\) 113-51-23; e-mail: )Tj 0 Tw -10.534 -1.2 Td (olga.linnik@servier.com)Tj /T1_2 1 Tf 0.01 Tc 0.072 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.077 Tw 14.159 0 Td [( Linnik Olg)12(a Zhanovna, JSC \244Ser)-42(vier\245, Lesnaya st., 7, Moscow)52(, 125196, R)22(ussia; phone:)]TJ /Span<>> BDC ( )Tj EMC (+7 \(915\) 113-51-23; )Tj 0.023 Tw -14.164 -1.2 Td [(e-mail: olg)12(a.linnik@ser)-41.9(vier)51.1(.com.)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 20.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 20.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 469.0919 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.277 Tw 10 0 0 10 42.5197 444.7359 Tm (\206\036\n\024\030\030\024\005)Tj /Span<>> BDC ( )Tj EMC 4.504 0 Td [(\227 )0.5(\024\007\027\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.442 0 Td [(\027\026\017\002\024\035\036\036 )0.6(\030\026\f\023\030\024\f\021\030\026\027\201\027\027\t\b )]TJ 0.225 Tw -9.947 -1.218 Td (\023\030\017\004\017\027 \024\002\030\026\013\036\027\017\016 \023\026\006\ \017\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\r\030\026\004\031 \f)Tj /Span<>> BDC ( )Tj EMC (\032\026\035\024\002\026\n\017 )Tj 0.061 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\036 \023\030\024\002\035\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\030\036\022\021\026\035\034\027\024\005 \024\002\035\026\f\021\ \017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f)Tj 0 Tw (-)Tj 0.186 Tw T* (\023\030\024\f\021\030\026\027\201\027\027\024\f\021\034\033 \007\024)Tj /Span<>> BDC ( )Tj EMC (44% [1]. \222\017\n\023\021\024\n\t \020\036\n\024\030\030\024\016 )Tj 0.059 Tw T* (\r\022\035\033\004\026\033\021 \022\030\024\r\024\021\036\004\036\027\017\ \036, \r\t\023\026\007\036\027\017\036 \031\035\024\r, \002\024\035\034\ , \031\007, )Tj 0.08 Tw T* (\007\017\f\022\024\n\235\024\030\021. \025\026\004\036\f\021\r\036\027\027\ \t\036 \017\f\f\035\036\007\024\r\026\027\017\016 \023\024\022\026\t\r\026\ )Tj 0 Tw (-)Tj 0.15 Tw T* (\033\021, \004\021\024 \f\017\n\023\021\024\n\t \020\036\n\024\030\030\024\ \016 \024\022\026\t\r\026\033\021 \r\t\030\026\032\036\027\027\024\036 \ )Tj 0.213 Tw T* (\r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\024 \032\017\027\017 \023\026\006\017\036\027\021\ \024\r [1], \r\035\017\016\033\021 )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\b \023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\ \024\f\021\034 [2,3].)Tj -0.01 Tc 0.512 Tw T* [(\200\026\032\027\024 )0.5(\024\021\n\036\021\017\021\034, )0.5(\004\021\024 )0.5(\023\030\036\007\f\021\026\r\035\036\027\017\016 )0.5(\023\026\006\017\036\027\021\026 )0.5(\024\002)-10( )]TJ 0.094 Tw T* (\031\f\023\036\001\027\024\f\021\017 \035\036\004\036\027\017\016 \n\024\ \020\031\021 \f\017\035\034\027\024 \024\021\035\017\004\026\021\034\f\016\ \024\021 \022\030\017)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.051 Tw T* (\021\036\030\017\036\r \031\f\023\036\001\027\024\f\021\017 \035\036\004\ \036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\021\024\004\022\017 \030\036\027\017\016 \r\030\026\004\026 [3].)-10( )]TJ -0.023 Tw T* (\213\r\030\024\023\036\005\f\022\024\036 \024\002\013\036\f\021\r\024 \022\ \024\035\024\023\030\024\022\021\024\035\024\020\017\017 \(ESCP\) \r)Tj /Span<>> BDC ( )Tj EMC [(2019)-9.9( )]TJ 0.324 Tw T* [(\020\024\007\031 \024\023\031\002\035\017\022\024\r\026\035\024 \024\f\027\ \024\r\027\024\005 \027\026\002\024\030 \017\f\b\024\007\024\r \(\210\203\ \230,)-10( )]TJ 0.169 Tw T* [(\026\027\020\035. C)13(OS\) \007\035\016 \020\036\n\024\030\030\024\016, \023\024\007\004\036\030\ \022\017\r\026\033\013\017\005 \r\026\032\027\024\f\021\034)-9.9( )]TJ 0.077 Tw T* (\031\004\201\021\026 \n\027\036\027\017\016 \023\026\006\017\036\027\021\ \026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\f\036\007\027\036\r\027\024\005 \023\030\026\022\021\017\022\036\ ,)-10( )]TJ 0.075 Tw T* [(\021\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.377 0 Td [(\r )0.5(\027\026\031\004\027\t\b )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\b )0.5([4]. )0.5(\210\f\027\024\r\027\t\n\017 )0.5(\017\f\b\024)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc 0.086 Tw -2.377 -1.218 Td [(\007\026\n\017, \023\030\036\007\f\021\026\r\035\016\033\013\017\n\017 \017\ \027\021\036\030\036\f \007\035\016 \024\006\036\027\022\017 \r\035\017\016\ \027\017\016)-10( )]TJ -0.059 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \021\024\005 \017\035\017 \017\027\024\005 \f\021\030\026\021\ \036\020\017\017 \035\036\004\036\027\017\016, \016\r\035\016\033\021\f\016\ \f\017\n\023)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc -0.032 Tw T* (\021\024\n\t \020\036\n\024\030\030\024\016, \026)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\n)Tj /Span<>> BDC ( )Tj EMC (\227 \031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\034 \035\ \036)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.061 Tw T* (\004\036\027\017\036\n. \233\021\017 \017\f\b\024\007\t \035\031\004\001\ \036 \r\f\036\020\024 \017\n\036\030\016\021\034 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033)-10( )]TJ 0.138 Tw T* [(\023\024\022\026\026\021\036\035\036\005, \f\024\024\002\013\026\036\n\t\ \b \f\026\n\017\n \023\026\006\017\036\027\021\024\n \(p)32(a)15.1(t)-32(ient-)]TJ -0.039 Tw T* [(r)-24(epor)-21.9(ted outcome measur)-23.9(e, PROM\), \022\024\021\024\030\t\036 \f\024\002\017\030\026\033\021\f\016\ )-10( )]TJ 0.057 Tw T* [(\027\026\023\030\016\n\031\033 \024\021 \023\026\006\017\036\027\021\026\ \002\036 \017\027\021\036\030\023\030\036\021\026\006\017\017 \f\024 \f\ \021\024\030\024\027\t)-10( )]TJ 0 Tw T* (\n\036\007\017\006\017\027\f\022\017\b \030\026\002\024\021\027\017\022\024\ \r \017\035\017 \007\030\031\020\017\b \035\017\006 [5].)Tj 0 Tc 0.127 Tw T* (\203\036\007\026\r\027\024 \002\t\035 \030\026\030\026\002\024\021\026\027\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\035\017\007\017\030\024\r\026\027 PROM, \f\023\036)Tj 0 Tw (-)Tj 0.227 Tw T* (\006\017\026\035\034\027\024 \023\030\036\007\027\026\027\026\004\036\027\ \027\t\005 \007\035\016 \023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030)Tj 0 Tw (-)Tj 0.03 Tw T* (\030\024\036\n)Tj /Span<>> BDC ( )Tj EMC (\227 \001\022\026\035\026 \024\006\036\027\022\017 \f\021\036\023\036\027\ \017 \r\035\017\016\027\017\016 \026\002\024\035\036\r\026\027\017\016 \ )Tj 0.282 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\024\f\021\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\017 )Tj 0.256 Tw T* [(\035\036\004\036\027\017\036\n \(PROM-HIS)17(S\) [6]. PROM-HIS)17(S \002\t\035 \f\024\007\026\027 )]TJ 0.379 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\036 \017\027\021\036\030\r\034\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017, \f\021\030\026\007\026\033\013\017\ \n\017 )Tj 0.131 Tw 23.244 38.97 Td (\020\036\n\024\030\030\024\036\n, \026)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \030\026\030\026\002\024\021\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\f\021\017\030\024\r\026\027\017\036 \f\021\030\024\020\024 )Tj -0.031 Tw T* [(\f\024\024\021\r\036\021\f\021\r\024\r\026\035\017 \030\036\022\024\n\036\ \027\007\026\006\017\016\n C)13(OSMIN [3,7]. PROM-)]TJ 0.179 Tw T* [(HIS)17(S )0.5(\023\030\017\027\026\027 )0.6(\r\026\035\017\007\027\t\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.614 0 Td [(\027\026\007\201\032\027\t\n )0.5(\017\027\f\021\030\031\n\036\027\021\024\n )]TJ 0.235 Tw -11.614 -1.218 Td (\007\035\016 \024\006\036\027\022\017 \f\017\n\023\021\024\n\024\r \020\036\ \n\024\030\030\024\016, \r\035\017\016\027\017\016 \002\024\035\036\027\ \017 )Tj 0.302 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\f\036\007\027\036\r\027\031\033 \026\022\021\017\r\027\024\f\021\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\031\007\024\r\035\036\021\r\024\030\201\027\027\024\f\021\034 )Tj 0 Tw T* (\023\026\006\017\036\027\021\026 \035\036\004\036\027\017\036\n [6].)Tj -0.002 Tc -0.071 Tw T* [(\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 PROM-HIS)17(S \007\024\f\021\031\023\036\027 \021\024\035\034\022\024 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\020\024\035)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.107 Tw T* (\035\026\027\007\f\022\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\020\035\017\005\f\022\024\n \016\t\022\026\b [6,8]. \232\021\024\ \002\t \024\002\036\f\023\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.2 Tw T* [(\004\017\021\034 \001\017\030\024\022\024\036 \020\036\024\020\030\026\235\ \017\004\036\f\022\024\036 \023\030\017\n\036\027\036\027\017\036 \007\026\ \027\027\024\020\024)-2( )]TJ 0.377 Tw T* [(\017\027\f\021\030\031\n\036\027\021\026, \f\035\036\007\031\033\013\017\ \n \001\026\020\024\n \016\r\035\016\036\021\f\016 \023\036\030\036\r\024\ \007)-2( )]TJ 0.167 Tw T* [(PROM-HIS)17(S \027\026)]TJ /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\036 \016\t\022\017 \n\017\030\026. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.199 Tw T* [(\007\024\r\026\027\017\017 \024\023\017\f\t\r\026\036\021\f\016 \023\030\ \024\006\036\f\f \023\036\030\036\r\024\007\026 PROM-HIS)17(S)-2( )]TJ 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f\f\022\017\005 \016\t\022 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005 \r\ \026\035\017\007\026\006\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 286.4219 Tm [(\207\034)-31(\024)35(\037\230\037\r\037\021\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf -0.012 Tc 0.021 Tw 10 0 0 10 274.9606 262.0659 Tm (\212\017\026\005\027 \007\026\027\027\024\020\024 \017\f\f\035\036\007\024\ \r\026\027\017\016 \f\024\f\021\024\016\035 \017)Tj /Span<>> BDC ( )Tj EMC [(\007\r\031\b \004\026\f\021\036\005:)-12( )]TJ -0.052 Tw T* [(1\) \016\t\022\024\r\024\005 \023\036\030\036\r\024\007 PROM-HIS)17(S \f)]TJ /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\031\f)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.071 Tw T* (\f\022\017\005 \016\t\022; \017)Tj /Span<>> BDC ( )Tj EMC (2\) \022\030\024\f\f-\022\031\035\034\021\031\030\027\026\016 \r\026\035\ \017\007\026\006\017\016 \030\031\f\f\022\024\016)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.171 Tw T* [(\t\004\027\024\005 \r\036\030\f\017\017 PROM-HIS)17(S \r)]TJ /Span<>> BDC ( )Tj EMC [(\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017.\ )-12( )]TJ 0.192 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f\036 \023\036\030\036\r\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005 \r\026\035\017\ \007\026\006\017\017)-12( )]TJ 0.141 Tw T* (\002\t\035\017 \f\024\002\035\033\007\036\027\t \024\235\017\006\017\026\ \035\034\027\t\036 \030\036\022\024\n\036\027\007\026\006\017\017 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\023\036)Tj 0 Tc 0 Tw (-)Tj -0.012 Tc 0.393 Tw T* [(\030\036\r\024\007\031 \017\f\b\024\007\024\r, \f\024\024\002\013\026\036\ \n\t\b \023\026\006\017\036\027\021\026\n\017 \(P)40(a)15(t)-32(ient-)]TJ -0.03 Tw T* [(R)13(epor)-21.9(ted )0.5(Outcomes )0.5(Measur)-23.9(es )0.5(\017\035\017 )0.5(PROM\). )0.6(\230\f\023\024\035\034\024\r\026\027\t)-12( )]TJ 0.151 Tw T* [(\030\031\022\024\r\024\007\016\013\017\036 \023\030\017\027\006\017\023\t\ \027\026\007\035\036\032\026\013\036\005 \023\030\026\022\021\017\022\017\ ISPOR)-12( )]TJ 0 Tw T* ([9] \007\035\016 \022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005\ \023\030\024\r\036\030\022\017 PROM.)Tj /T1_5 1 Tf 0 Tc 0 -2.436 TD (\223\213\013\220\002\002\005 \212\r\006\r\002\240)Tj /T1_3 1 Tf 0.281 Tw 0 -1.218 TD (\215\030\016\n\024\005 \023\036\030\036\r\024\007 \023\030\024\017\r\024\ \007\017\035\f\016 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\024\020\024 \016\t\022\026 )Tj 0.035 Tw T* (\(\020\024\035\035\026\027\007\f\022\024\020\024\) \027\026)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\036\r\024\005 \016\t\022 \(\030\031\f\f\022\017\005\) \007\ \r\031\n\016 \027\036)Tj 0 Tw (-)Tj 0.254 Tw T* (\026\r\017\f\017\n\t\n\017 \027\024\f\017\021\036\035\016\n\017 \030\031\ \f\f\022\024\020\024 \016\t\022\026, \f\r\024\002\024\007\027\024 )Tj 0 Tw T* (\020\024\r\024\030\016\013\017\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\024\035\035\026\027\007\f\022\024\n.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 505.4271 56.0378 Tm (135)Tj ET endstream endobj 709 0 obj [713 0 R] endobj 710 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 325.5411 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 325.5411 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 288.3333 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 288.3333 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-134-141)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 90.3587 695.3259 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \213\212\217\r)10(\025\b\025\221 \n\022)-23.2(\r\005\025\016\016-\r\002\020\200)21(\026)-19.9(\002\005\t\025\221 \b\017\020\n\202\017\n\n )]TJ 0.228 -1.105 Td [(\025\224\005\025\016\t\n\r\017 PRO)20.1(M-HIS)21(S \202)-21(\020\213 \224\017\n\004\t\026)11(\025\b \016\022)-23.3(\013)10(\004\024\025\005\005\025\004\024)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 649.822 Tm [(\222\004\020\217\013\n\t\022)-23.2(\207.\f)-31(.)]TJ 8.162 0 0 8.162 158.3548 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 162.9908 649.822 Tm [(, \037)31(\025\016)-10(\026)11(\017\005\004\b\022)-23.2(\030.\021.)]TJ 0 Tw 8.162 0 0 8.162 252.906 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 257.5419 649.822 Tm [(, \037)20(\b\017\016\t\n\r)10(\025\b\022)-23.2(\006.\006.)]TJ 0 Tw 8.162 0 0 8.162 352.1047 654.484 Tm (2)Tj 0.023 Tw 14 0 0 14 356.7407 649.822 Tm [(, \035\n\t\t\n\r\022)-23.2(\036.\223.)]TJ 0 Tw 8.162 0 0 8.162 441.7556 654.484 Tm (2)Tj 5.83 0 0 5.83 70.8661 635.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 632.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 611.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 608.1527 Tm [(\f\036 \253\001\004\005\b\200\004\273 \(\002\020.\022)-23.3(\035\004\016\t\017\213 \202.\022)-23.3(7)127(, \235\025\016\r\b\017, 1)125(2)23(5)127(1)138(9)23(6, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf 0.086 Tw 9 0 0 9 119.0551 589.6488 Tm [(\216\027\026\031\032\032\031\235 )0.6(\t\021\f\t\027\023\024\t )0.6(\031\030\025\022\026 )0.6(\022\016)]TJ /Span<>> BDC ( )Tj EMC 12.524 0 Td [(\025\020\022\240\031\f\027\027 )0.6(\032\020\024\033\032\031\024\023\032\020\025\027\025\025\013\200 )0.7(\016\020\240\031\f\027\021\020\025\022\235 )0.5(\020\025\031\032\027\n\023\020\f\017\025\031\235 )0.6(\031\240\f\020\024\023\022, )0.5(\025\027\b\020\023\022\021)]TJ 0 Tw (-)Tj 0.151 Tw -12.524 -1.111 Td (\025\031 \021\f\022\t\005\212\022\200 \025\020)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\031 \255\022\016\025\022 \033\020\006\022\027\ \025\023\031\021. PROM-HISS)Tj /Span<>> BDC ( )Tj EMC (\227 \024\031\021\032\027\026\027\025\025\013\235 \031\033\032\031\024\025\ \022\n, \024\031\016\030\020\025\025\013\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\024\025\031\021\027 )Tj 0.078 Tw 0 -1.111 TD (\032\027\n\031\026\027\025\030\020\006\022\235 COSMIN \(Consensus-based \ Standards for the)Tj /Span<>> BDC ( )Tj EMC (selection of)Tj /Span<>> BDC ( )Tj EMC (health status Measurement Instruments\) )Tj 0.117 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\021\n\f\005\007\020\005\212\022\235 \031\006\027\025\n\r \024\022\026\033\ \023\031\026\031\021 \016\020\240\031\f\027\021\020\025\022\t, \021\f\022\ \t\025\022\t \b\027\026\031\032\032\031\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\024\027\030\025\027\021\025\r\005 \020\n\023\022\021\025\031\ \024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\r )Tj 0.169 Tw T* (\r\030\031\021\f\027\023\021\031\032\233\025\025\031\024\023\022 \033\032\ \031\021\027\030\027\025\025\013\026 \f\027\007\027\025\022\027\026. \217\ \033\032\031\024\025\022\n \032\020\016\032\020\240\031\023\020\025 \025\ \020)Tj /Span<>> BDC ( )Tj EMC (\b\031\f\f\020\025\030\024\n\031\026 \t\016\013\n\027 \022)Tj /Span<>> BDC ( )Tj EMC (\021\020\f\022\030\022\032\031\021\020\025 )Tj 0.023 Tw 0 -1.111 TD (\025\020)Tj /Span<>> BDC ( )Tj EMC (\020\025\b\f\022\235\024\n\022\235 \t\016\013\n.)Tj 0.25 Tw 0 -1.111 TD (\037\036\035\034: \033\032\031\021\027\024\023\022 \t\016\013\n\031\021\r\ \005 \020\030\020\033\023\020\006\022\005 \022)Tj /Span<>> BDC ( )Tj EMC (\n\032\031\024\024-\n\r\f\017\023\r\032\025\r\005 \021\020\f\022\030\020\ \006\022\005 PROM-HISS \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\r\024\024\n\022\235 \t\016\013\n \030\f\t )Tj 0.023 Tw T* (\022\024\033\031\f\017\016\031\021\020\025\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\206\214.)Tj 0.117 Tw T* (\215\036\217\220\201: \033\027\032\027\021\031\030 \031\033\032\031\024\ \025\022\n\020 \021\013\033\031\f\025\027\025 \030\021\r\026\t \025\027\016\ \020\021\022\024\022\026\013\026\022 \033\027\032\027\021\031\030\007\022\ \n\020\026\022 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\030\r\005\212\022\026 \031\240\236\027\030\022\025\027\ \025\022\027\026 )Tj -0.014 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\031\240\024\r\255\030\027\025\022\027\026 \023\027\032\026\022\025\031\f\ \031\b\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\032\020\240\031\007\027\235 \b\032\r\033\033\031\235, \021\n\f\005\007\020\ \005\212\027\235 \n\031\f\031\033\032\031\n\023\031\f\031\b\020 \022)Tj /Span<>> BDC ( )Tj EMC (\024\033\027\006\022\020\f\022\024\023\031\021 \026\027\030\022\006\022\025\ \024\n\031)Tj 0 Tw (-)Tj 0.014 Tw T* (\b\031 \033\027\032\027\021\031\030\020. \004\032\031\021\027\030\233\025\ \031\240\032\020\023\025\013\235 \033\027\032\027\021\031\030 \030\f\t \ \n\031\025\023\032\031\f\t \n\020\007\027\024\023\021\020 \022)Tj /Span<>> BDC ( )Tj EMC (\024\031\200\032\020\025\027\025\022\t \n\031\025\006\027\033\023\r\020\f\ \017\025\031\b\031 \024\031\031\023\021\027\023)Tj 0 Tw (-)Tj 0.049 Tw T* (\024\023\021\022\t \031\032\022\b\022\025\020\f\r. \211)Tj /Span<>> BDC ( )Tj EMC (\032\020\026\n\020\200 \n\032\031\024\024-\n\r\f\017\023\r\032\025\031\235\ \033\032\031\021\027\032\n\022 \024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \n\031\b\025\022\023\ \022\021\025\013\200 \022\025\023\027\032\021\017\005 \r\007\020\024\023\ \021\031)Tj 0 Tw (-)Tj 0.06 Tw T* (\021\020\f\022 10 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\025\013\026\022 \024\023\020\030\022\t\026\022 \200\032\031\ \025\022\007\027\024\n\031\b\031 \b\027\026\031\032\032\031\t \(\n\f\020\ \024\024\022\203\022\n\020\006\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (Goligher\). \217\240\024\r\255\030\020\f\022\024\017 )Tj 0.023 Tw T* (\033\031\025\t\023\025\031\024\023\017, \033\031\f\025\031\023\020 \022)Tj /Span<>> BDC ( )Tj EMC (\032\027\f\027\021\020\025\023\025\031\024\023\017 \021\031\033\032\031\024\ \031\021 \022)Tj /Span<>> BDC ( )Tj EMC (\021\020\032\022\020\025\023\031\021 \031\023\021\027\023\031\021.)Tj 0.121 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \031\033\032\031\024\025\022\n PROM-\ HISS_RU \031\240\f\020\030\020\027\023 \200\031\032\031\213\027\235 \021\ \025\027\213\025\027\235 \022)Tj /Span<>> BDC ( )Tj EMC (\024\031\030\027\032\255\020\023\027\f\017\025\031\235 \021\020\f\022\030\ \025\031\024\023\017\005, \020\030\027\n)Tj 0 Tw (-)Tj 0.203 Tw 0 -1.111 TD [(\021\020\023\025\031 )0.5(\031\023\032\020\255\020\027\023 )0.5(\024\022\026\033\023\031\026\013 )0.6(\b\027\026\031\032\032\031\t, )0.5(\022\200 \021\f\022\t\025\022\027 )0.6(\025\020)]TJ /Span<>> BDC ( )Tj EMC [(\n\020\007\027\024\023\021\031 )0.5(\255\022\016\025\022 \022)]TJ /Span<>> BDC ( )Tj EMC 32.046 0 Td (\r\030\031\021\f\027\023\021\031\032\233\025\025\031\024\023\017 \f\027\007\ \027\025\022\027\026. )Tj 0.149 Tw -32.046 -1.111 Td (\210\007\020\024\023\025\022\n\022 \031\006\027\025\022\f\022 \031\033\032\ \031\024\025\022\n \n\020\n \033\031\025\t\023\025\013\235, \022\025\203\ \031\032\026\020\023\022\021\025\013\235 \022)Tj /Span<>> BDC ( )Tj EMC (\n\031\026\033\020\n\023\025\013\235. \211)Tj /Span<>> BDC ( )Tj EMC (\200\031\030\027 \021\020\f\022\030\020\006\022\022 \021\025\027\024\027\ \025\013 )Tj 0.023 Tw T* (\026\022\025\022\026\020\f\017\025\013\027 \t\016\013\n\031\021\013\027 \ \022)Tj /Span<>> BDC ( )Tj EMC (\023\027\032\026\022\025\031\f\031\b\022\007\027\024\n\022\027 \n\031\032\ \032\027\n\006\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\024\031\200\032\020\025\027\025\022\027\026 \024\026\013\024\f\031\021\031\ \235 \024\023\032\r\n\023\r\032\013 \031\033\032\031\024\025\022\n\020.)Tj -0.031 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.5(\031\033\032\031\024\025\022\n )0.5(PROM-HISS_RU )0.5(\t\021\f\t\027\023\024\t )0.5(\030\027\235\024\023\021\027\025\025\013\026 )0.5(\022\025\024\023\032\r\026\027\025\023\031\026 )0.5(\030\f\t \031\006\027\025\n\022 \024\022\026\033\023\031\026\031\021 \b\027\ \026\031\032)]TJ 0 Tw (-)Tj 0.023 Tw T* (\032\031\t \022)Tj /Span<>> BDC ( )Tj EMC (\027\b\031 \021\f\022\t\025\022\t \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\024\027\030\025\027\021\025\r\005 \030\027\t\023\027\f\017\025\ \031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\r\030\031\021\f\027\023\021\031\032\027\025\025\031\024\023\017 \033\020\ \006\022\027\025\023\031\021 \f\027\007\027\025\022\027\026.)Tj /T1_2 1 Tf 0.01 Tc -0.015 Tw 8 0 0 8 70.906 384.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc -0.01 Tw 8.46 0 Td ( \031\033\032\031\024\025\022\n \030\f\t \031\006\027\025\n\022 \n\020\007\ \027\024\023\021\020 \255\022\016\025\022 \022)Tj /Span<>> BDC ( )Tj EMC (\r\030\031\021\f\027\023\021\031\032\027\025\025\031\024\023\022 \f\027\007\ \027\025\022\027\026 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\b\027\026\031\032\032\031\027\026, PROM-HISS, \b\027\026\031\032\032\031\ \235)Tj /T1_2 1 Tf 0.01 Tc 0.066 Tw -8.46 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.071 Tw 10.449 0 Td ( \237\027\f\013\b\022\025 \224.\003. \016\020\t\021\f\t\027\023 \031\240\ \031\023\024\r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\ \025\023\027\032\027\024\031\021. \202\031\024\023\020\032\027\021 \002.\ \211. \024\031\031\240\212\020\027\023 \031)Tj /Span<>> BDC ( )Tj EMC (\033\031\f\r\007\027\025\022\022 \b\031\025\031)Tj 0 Tw (-)Tj 0.043 Tw -10.454 -1.2 Td [(\032\020\032\031\021 )0.5(\016\020)]TJ /Span<>> BDC ( )Tj EMC (\f\027\n\023\031\032\024\n\r\005 \022)Tj /Span<>> BDC ( )Tj EMC [(\n\031\025\024\r\f\017\023\020\023\022\021\025\r\005 \033\031\030\030\027\ \032\255\n\r )0.5(\n\031\026\033\020\025\022\022 )0.5(\253\205\027\032\021\017\027\273. )0.5(\202\021\020\024\025\022\n\031\021 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/Span<>> BDC ( )Tj EMC (\230.\200., \025\r\026\f\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\207.\207., \214\017\027\027\017\022)Tj /Span<>> BDC ( )Tj EMC (\210.\240. \217\036\031\035\034\021\026\021\t \016\t\022\024\r\024\005\ \017)Tj /Span<>> BDC ( )Tj EMC [(\022\030\024\f\f-\022\031\035\034\021\031\030\027\024\005 \r\026\035\017\ \007\026\006\017\017)12( )]TJ -0.011 Tc -0.063 Tw -8.961 -1.2 Td (\024\023\030\024\f\027\017\022\026 PROM-HISS \007\035\016 \023\026\006\017\ \036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\020\036\n\024\030\030\024\036\n. )Tj /T1_0 1 Tf 0.011 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.063 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (134\226141. https://doi.org/10.33878/2073-7556-2026-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (25-1-134-141)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 165.3393 262.164 Tm [(Results of\022)-23.3(linguistic and cr)20.1(oss-cultur)21(al )]TJ -1.265 -1.167 Td [(v)10(alidation of\022)-23.3(th)11(e PRO)20(M-HIS)21.1(S questionnair)31.1(e )]TJ 1.008 -1.167 Td [(for patients with h)11(emorrh)11(oidal disease)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 195.66 Tm [(Y)40(ur)-31(y\022)-23.2(A)-31(.\022)-23.3(Sh)11(ely)10(gin)]TJ 8.162 0 0 8.162 164.4486 200.322 Tm (1)Tj 0.023 Tw 14 0 0 14 169.0845 195.66 Tm [(, Iv)10(an\022)-23.3(V)62.1(.\022)-23.3(K)40.9(ostar)31.1(e)11(v)]TJ 0 Tw 8.162 0 0 8.162 267.3759 200.322 Tm (1)Tj 0.023 Tw 14 0 0 14 272.0119 195.66 Tm [(, Boris\022)-23.2(B.\022)-23.3(K)41(v)10(asnik)11(ov)]TJ 0 Tw 8.162 0 0 8.162 381.5723 200.322 Tm (2)Tj 0.023 Tw 14 0 0 14 386.2083 195.66 Tm [(, Olga\022)-23.2(Zh.\022)-23.3(Linnik)]TJ 0 Tw 8.162 0 0 8.162 480.0464 200.322 Tm (2)Tj 5.83 0 0 5.83 70.8661 181.3208 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 177.9908 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 169.3208 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 165.9908 Tm [(JSC \232Ser)-20.9(vier\233 \(Lesnay)21.1(a\022)-23.3(st., 7)127(, Moscow)22(, 1)125(2)23(5)127(1)138(9)23(6, Russia\))]TJ /T1_0 1 Tf 0.129 Tw 9 0 0 9 119.0551 147.4869 Tm [(AIM: to per)-34(for)-13.9(m languag)12(e ad)26(ap)13(tation into R)22(ussian and cross-cultural v)16(alid)26(ation of P)66(R)19.1(OM-HISS for its use in the )]TJ 0.023 Tw 0 -1.111 TD [(R)22(ussian F)11(ederation.)]TJ 0.091 Tw T* [(METHODS: the q)14(uestionnaire w)13(as translated by tw)12(o independent translators, then combined and discussed with a )]TJ 0.13 Tw T* [(w)12(orking g)14(roup including a p)46(roctologist and medical translation specialists. A back)32(-translation w)13(as conducted to )]TJ 0.055 Tw T* [(ensure q)14(uality control and concep)13(tual f)-43(idelity to the or)-36.9(iginal. T)54(en patients with v)15.9(ar)-43(ying stag)12(es of chronic haemor)]TJ 0 Tw 44.743 0 Td (-)Tj 0.149 Tw -44.743 -1.111 Td [(rhoids )0.5(\(Goligher\222)37.1(s classif)-42.9(ication\) )0.5(par)-40(ticipated )0.5(in )0.5(cross-cultural )0.5(v)16(alid)26.1(ation )0.5(using cognitiv)13(e inter)-42(vie)10(ws. The )0.5(clar)-37(ity)41.9(, )]TJ 0.023 Tw T* [(com)16(pleteness, and relev)16.1(ance of the q)14(uestions and answ)12(er op)13(tions w)12(ere discussed.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 598.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 589.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 155.9912 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 147.0639 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 20.8402 56.0378 Tm (134)Tj ET 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[(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_2 1 Tf 0.936 Tw [( \205)27.6(\r)9.3(\213)7.2(\n)9.8(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\217)27.6(.)29.3(\002)28.8(.)7.8(, \205)27.6(\r)-4.3(\032\031)9.6(\021)-0.8(\027)0.7(\b)10(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\036)22.8(.)43.7(\205)-2.1(. )]TJ -0.01 Tc 0.01 Tw 0 -1.218 TD [(\214)-2.9(\032)-9.9(\031\f)-6.6(\031\021)]TJ /Span<>> BDC 2.968 0 Td ( )Tj EMC [(\205)-12.1(.)-2.7(\003)-12.2(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -2.968 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.304 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_2 1 Tf [( O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.6(h)7.5(k)13(o)-0.6(v)33.6(, )]TJ 0 Tw 0 -1.218 TD [(E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(S)2.2(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.6(e)-3.5(g)-14.5(i)8.4(n)-6(, E)20.7(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(K)0.7(h)1.9(o)0.5(m)4.8(y)3.8(a)1.7(k)12.9(o)-0.6(v)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_2 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(I)-18.1(s)9.3(l)3.3(a)-0.8(m)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(a)-4.4(v)0.9(l)3.3(a)-4.5(e)-3.9(v)33.5(, M)5.3(a)-17(x)-26.2(i)8.4(m)]TJ /Span<>> BDC ( )Tj EMC [(O)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)5.2(l)4.3(u)-1.6(d)-1(o)-0.6(v)33.6(, Y)33.7(u)2.9(l)4.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(E)19.6(l)10.4(\243)9(m)-1.1(o)-0.6(v)10.8(a)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-13.9(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_2 1 Tf 0 Tc 0 Tw 9.088 0 Td [( A)9.6(i)9.4(r)7.7(a)-4.9(t)]TJ /Span<>> BDC ( )Tj EMC [(F)65.3(.)]TJ /Span<>> BDC ( )Tj EMC [(M)10.5(i)8.4(n)3.8(ga)-4.5(z)12.4(o)-0.6(v)33.7(,)]TJ /T1_1 1 Tf -0.128 Tw -9.088 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_2 1 Tf [( I)-18.1(s)9.3(l)3.3(a)-0.8(m)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.3(h)4.8(a)-4.4(v)0.9(l)3.3(a)-4.5(e)-4(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.6(e)-3.5(g)-14.5(i)8.4(n)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw 0 -1.218 TD [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_2 1 Tf 0 Tc 0.708 Tw 3.238 0 Td [( O)-7.4(l)4.9(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(us)9.7(h)7.4(k)13(o)-0.6(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(o)-0.6(v)6.7(e)-3.6(g)-14.4(i)8.4(n)-6(, )]TJ -0.002 Tc 0.002 Tw -3.238 -1.218 Td [(S)3.6(e)-3.7(rg)-4.5(e)-4.5(y)]TJ /Span<>> BDC 2.567 0 Td ( )Tj EMC [(A)-14.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(F)32.1(ro)-3.1(l)0.9(o)-2.5(v)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.646 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\231\026\r\035\026\036\r \230.\217.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0000-7500-6245)Tj 23.244 19.485 Td (\222\031\030\024\r\036\020\017\027 \213.\222.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-5743-1344)Tj T* (\205\030\024\035\024\r \222.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4697-2839)Tj T* (\204\017\027\020\026\024\r \202.\205.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj T* (\207\035\031\007\024\r \204.\210.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0001-0816-2560)Tj T* (\213\035\235\017\n\024\r\026 \224.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0007-3316-7041)Tj T* (\216\024\n\016\022\024\r \213.\202)Tj /Span<>> BDC ( )Tj EMC (\227 0009-0005-4677-1841)Tj 0 -1.218 TD (\222\031\001\022\024\r \210.\230.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Isl)-16(am R. S)-15.9(havl)-16(aev)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0000-7500-6245)Tj T* [(Ev)-21(geni)-16(i S. Sur)-31.9(ovegin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5743-1344)Tj T* [(Ser)-32(ge)-11(y A. F)10.1(r)-32(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4697-2839)Tj 0 -1.218 TD [(Air)-33(a)15(t F. Minga)-23.9(zov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4558-560X)Tj 0 -1.218 TD [(Maxim O. Bl)35.1(ud)-16(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0001-0816-2560)Tj 0 -1.218 TD [(Y)35(ul)-31(ia A. El\225mov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3316-7041)Tj T* [(Ev)-21(geniy A. Khomy)22.1(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-4677-1841)Tj T* (Oleg I. Sushkov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-9780-7916)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 493.4479 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.072 Tw 8 0 0 8 42.5197 480.6132 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mehme)-12(t )0.5(A)15(yhan )0.5(K)25(uzu. )0.6(S)15(t)15(and)42(ar)-24(dizing )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 16.33 0 Td [(Def)-28(ini)-24(t)-31.9(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.573 0 Td [(Ea)-17(ch )0.5(Col)30(on )]TJ 0.14 Tw -23.199 -1.25 Td [(Cancer Segment: Delphi Consensus on Cl)-31(inical Dec)-24(ision-Mak)-15.9(ing for )]TJ 0.095 Tw 0 -1.25 TD [(Oncol)30(o)-16(gic Outcomes. )]TJ /T1_2 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf [( 2025 Ap)25(r 11. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (DCR.0000000000003739)Tj 0 0 0 1 k /GS1 gs 0.096 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(anak)-17(a)]TJ /Span<>> BDC ( )Tj EMC [(S, Ma)15(tsud)42(a)]TJ /Span<>> BDC ( )Tj EMC [(A, Y)50(amad)42(a)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Segment)15.1(al or R)-24(ight Hemi-)]TJ 0.282 Tw -1.296 -1.25 Td [(Colec)-16(t)17(omy? )0.6(T)47(he)]TJ /Span<>> BDC ( )Tj EMC 7.002 0 Td [(Opt)-32(imal )0.6(Sur)-32(gical )0.6(P)35(r)-32(o)-16(cedur)-23.9(e )0.5(for )0.6(T)50(r)-33(ansver)-10(se )0.6(Col)30(on )]TJ 0.006 Tc 0.349 Tw -7.002 -1.25 Td (Cancer: A)Tj /Span<>> BDC ( )Tj EMC [(P)35.2(r)-31.8(opensi)-23.8(t)-9.8(y S)-23.8(cor)-23.8(e-Ma)15.2(tched, Mul)56.2(t)-31.9(icenter, R)13.1(e)-11.8(tr)-31.8(ospec)-15.8(t)-31.8(i)-15.8(ve)6( )]TJ 0 Tc 0 Tw T* [(S)15(tud)17(y. )]TJ /T1_2 1 Tf 0.171 Tw 2.946 0 Td [(Int J )0.5(Colorectal )0.5(Dis.)]TJ /T1_1 1 Tf [( )0.5(2023;38:58. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-023-)Tj -2.946 -1.25 Td (04360-6)Tj 0 0 0 1 k /GS1 gs 0.286 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Hyeong-Min )0.5(P)40(ar)-24(k. Distr)-36.9(ibut)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(l)35(ym)10(ph )0.5(node me)-12(t)15(ast)15(asis )0.5(and )]TJ 0.339 Tw -1.296 -1.25 Td [(oncol)30(o)-16(gical outcomes of)]TJ /Span<>> BDC ( )Tj EMC [(mid-tr)-33(ansver)-9.9(se col)30(on cancer: e)-18(xtended )]TJ 0.138 Tw T* [(ver)-10(sus tr)-33(ansver)-9.9(se colec)-15.9(t)17(omy. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf [( 2021 A)10(ug;23\(8\):2007\226)]TJ 0.023 Tw T* [(2013. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.15659)Tj 0 0 0 1 k /GS1 gs 0.023 Tw [( Epub 2021 Ap)25.1(r 17.)]TJ 0.009 Tc 0.353 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.324 0 Td (\025\035\017\027\017\004\036\f\022\017\036 \030\036\022\024\n\036\027\007\ \026\006\017\017. \003\035\024\022\026\004\036\f\021\r\036\027\027\t\036\ \027\024\r\024\024\002\030\026\024)Tj 0 Tc 0 Tw (-)Tj 0.268 Tw -1.324 -1.25 Td (\r\026\027\017\016 \024\002\024\007\024\004\027\024\005 \022\017\001\022\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\f\017\020\n\024\017\007\027\024\020\024 \024\021\007\ \036\035\026. \212\024\f\021\031\023\027\024 )Tj 0.003 Tc 0.349 Tw T* [(\023\024: ht)-29.7(tps://cr.minzdr)-32.7(av.gov.r)-21.6(u/p)25.3(r)-23.6(ev)-15.7(iew-cr/396_4. \222\f\t\035\022\026 \026\022\021\017\r)]TJ 0 Tc 0 Tw (-)Tj 0.001 Tc 0.35 Tw T* (\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC [(01.07.2025 / Cl)-31.3(inical R)12.7(ecommend)41.7(a)14.7(t)-32.3(ions. Mal)-31.2(ignant neo)]TJ 0 Tc 0 Tw (-)Tj 0.169 Tw T* [(pl)-16(as)26(ms of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he col)30(on and r)-24(ec)-16(t)17(osigmoid sec)-15.9(t)-32(ion. A)15.1(v)-15(ail)-16(able: ht)-30(tps://)]TJ 0.028 Tw T* [(cr.minzdr)-32.9(av.gov.r)-21.9(u/p)25(r)-24(ev)-16(iew-cr/396_4. )0.6(L)-31.9(ink )0.5(a)-17(c)-16(t)-31.9(i)-16(ve )0.6(as )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 22.75 0 Td (01.07.2025. )Tj 0.023 Tw -22.75 -1.25 Td (\(in Russ.\).)Tj 0.06 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(v)-15(an R)11(ongen)]TJ /Span<>> BDC ( )Tj EMC (I, Dambuis)Tj /Span<>> BDC ( )Tj EMC [(RA, v)-15(an der Hoeven)]TJ /Span<>> BDC ( )Tj EMC [(J)15.1(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison )]TJ 0.038 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(E)35(xtended Hemicolec)-16(t)17.1(omy V)30(er)-9.9(sus T)49.9(r)-32.9(ansver)-10(se Colec)-16(t)17.1(omy in P)40(a)15(t)-32(ients )]TJ -0.056 Tw T* [(wi)-24(t)-12.9(h Cancer of)]TJ /Span<>> BDC ( )Tj EMC 5.83 0 Td [(t)-13(he )0.5(T)49.9(r)-32.9(ansver)-10(se )0.5(Col)30(on. )]TJ /T1_2 1 Tf [(Acta )0.5(Chir Belg.)]TJ /T1_1 1 Tf ( 2013;113\(2\):107\226)Tj 0.023 Tw -5.83 -1.25 Td [(111. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1080/00015458.2013.11680794)Tj 0 0 0 1 k /GS1 gs 0.279 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Guan)Tj /Span<>> BDC ( )Tj EMC (X, Zhao)Tj /Span<>> BDC ( )Tj EMC [(Z, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Whe)-12(t)-12.9(her P)40(ar)-22(t)-32(ial Colec)-16(t)17.1(omy is )]TJ 0.001 Tw -1.296 -1.25 Td [(Oncol)30(o)-16(gicall)35.1(y Safe for )0.5(P)40(a)15(t)-32(ients )0.5(wi)-24(t)-13(h )0.5(T)50(r)-33(ansver)-10(se )0.5(Col)30(on Cancer: )0.5(A)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ar)-31.9(ge )]TJ 0.012 Tc 0.436 Tw T* [(P)10.2(opul)-15.8(a)15.2(t)-31.8(ion-Based S)15.2(tud)17.2(y. )]TJ /T1_2 1 Tf -0.012 Tw [(Onco)13.2(targ)12.2(et)]TJ /T1_1 1 Tf 0.436 Tw [(. 2017;8\(54\):93236\22693244.)12( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.18632/onco)17(t)15(ar)-32(ge)-11.9(t.21275)]TJ 0 0 0 1 k /GS1 gs 0.187 Tw -1.847 -1.25 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Mil)30(one)]TJ /Span<>> BDC ( )Tj EMC [(M, Degiul)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(M, All)-15.9(aix)]TJ /Span<>> BDC ( )Tj EMC [(M, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mid-tr)-32.9(ansver)-9.9(se col)30(on can)]TJ 0 Tw (-)Tj 0.007 Tc 0.35 Tw -1.296 -1.25 Td [(cer and e)-18.4(xtended ver)-10.4(sus tr)-33.4(ansver)-10.3(se colec)-16.4(t)16.6(omy: R)12.5(esul)55.6(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.4(he)7( )]TJ 0.006 Tc 0.349 Tw T* [(I)0.5(t)15.6(a)0.5(l)-30.5(i)0.6(a)0.5(n)0.5( s)0.5(o)-15.5(c)-23.4(i)0.5(e)-11.5(t)-9.4(y)0.5( o)0.5(f)]TJ /Span<>> BDC 7.734 0 Td ( )Tj EMC [(s)0.5(u)0.5(r)-31.4(g)0.5(i)0.5(c)0.5(a)0.6(l)0.5( o)0.6(n)0.5(c)0.5(o)0.5(l)30.6(o)-15.5(g)16.5(y)0.6( c)0.5(o)0.5(l)30.6(o)0.5(r)-23.4(e)0.5(c)-15.5(t)15.5(a)0.6(l)0.5( c)0.5(a)0.5(n)0.5(c)0.6(e)0.5(r)0.5( n)0.5(e)-11.5(t)-31.4(w)-13.5(o)0.5(r)-23.4(k)6( )]TJ 0 Tc 0.114 Tw 21.321 37.5 Td [(\(SIC)13(O CCN\) mul)56.1(t)-32(icenter coll)-16(abor)-33(a)15(t)-32(i)-15.9(ve stud)17(y. )]TJ /T1_2 1 Tf (Eur J Surg Oncol.)Tj /T1_1 1 Tf ( 2020 )Tj 0.161 Tw T* [(Sep;46\(9\):1683\2261688. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ejso.2020.01.006)Tj 0 0 0 1 k /GS1 gs 0.161 Tw ( Epub 2020 )Tj 0.023 Tw T* (Mar 19. PMID: 32220542.)Tj 0.037 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(M)-24(or)-33(ar)-32.9(asu)]TJ /Span<>> BDC ( )Tj EMC [(S, Cl)-16(ancy)]TJ /Span<>> BDC ( )Tj EMC [(C, Cr)-32(onin)]TJ /Span<>> BDC ( )Tj EMC [(CT, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Segment)15(al ver)-9.9(sus E)35(xtended )]TJ 0.008 Tc 0.35 Tw -1.296 -1.25 Td [(Colec)-16.2(t)16.7(omy for T)59.8(umour)-10.3(s of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13.3(he T)49.8(r)-33.3(ansver)-10.2(se Col)29.7(on: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-13.2(stema)14.8(t)-32.3(ic)8( )]TJ 0.009 Tc 0.349 Tw T* [(R)13.3(ev)-15.6(iew and Me)-11.7(t)15.3(a-Anal)35.3(y)-12.7(sis. )]TJ /T1_2 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf [( 2021;23\(3\):625\226634.)9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.15403)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.38 Tw -1.847 -1.25 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td [(Ar)-33.2(asar)-33.1(adnam)]TJ /Span<>> BDC ( )Tj EMC [(RP, Br)-32.2(o)-14.2(wn)]TJ /Span<>> BDC ( )Tj EMC [(S, F)9.8(or)-24.1(bes)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12.2(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Guidel)-31.2(ines for)10( )]TJ 0 Tc 0.25 Tw -1.327 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(invest)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(chr)-32(onic diar)-23.9(r)-24(hoea in adul)56(ts. Br)-36.9(i)-24(t)-32(ish S)-16(o)-16(c)-23.9(ie)-12(t)-10(y )]TJ 0.016 Tc 0.576 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Gastr)-31.8(oenter)-31.8(ol)30.2(o)-15.7(g)16.2(y. 3r)-23.8(d edi)-23.8(t)-31.7(ion. )]TJ /T1_2 1 Tf -0.016 Tw (Gut)Tj /T1_1 1 Tf 0.576 Tw [(. 2018;67:1380\2261399.)16( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1136/gutjnl-2017-315909)Tj 0 0 0 1 k /GS1 gs 0.223 Tw -1.847 -1.25 Td (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dind)-16(o)]TJ /Span<>> BDC ( )Tj EMC [(D, Demar)-21.9(t)-32(ines)]TJ /Span<>> BDC ( )Tj EMC [(N, Cl)-16(av)-16(ien)]TJ /Span<>> BDC ( )Tj EMC [(P)25(A. Cl)-16(assif)-28(ica)15(t)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical )]TJ 0.102 Tw -1.796 -1.25 Td [(com)10(pl)-31(ica)15.1(t)-32(ions: a)]TJ /Span<>> BDC ( )Tj EMC [(new p)25(r)-32(oposal wi)-24(t)-12.9(h ev)-15(al)35(ua)15(t)-32(ion in a)]TJ /Span<>> BDC ( )Tj EMC [(cohor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC (6336 )Tj 0.169 Tw T* [(p)32(a)15(t)-32(ients and r)-23.9(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(sur)-32(ve)-11(y. )]TJ /T1_2 1 Tf (Ann Surg.)Tj /T1_1 1 Tf ( 2004;240\(2\):205\226213. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1097/01.sl)-15.9(a.0000133083.54934.ae)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.464 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.846 0 Td [(\200\f\036\n)0.5(\017\030\027\026\016 \024\030\020\026\027)0.5(\017\026\006\017)0.5(\016 \007\030\026\r\024\024\b)0.5(\030\026\027\036\027\017)0.5(\016. \212\017\026\030\036\016)0.5( [\006)0.5(\017\021.)13( )]TJ 0 Tc 0.088 Tw -1.846 -1.25 Td [(2024 \n\026\030\021 07]. \230\027\235\024\030\n\026\006\017\024\027\027\t\ \005 \002\033\035\035\036\021\036\027\034; 2025. [W)20(or)-30(ld Heal)56.1(t)-13(h )]TJ 0.063 Tw T* [(Or)-32(ganiza)15(t)-31.9(ion. )0.5(Diar)-23.9(r)-24(hea )0.5([c)-23.9(i)-24(t)15(a)15(t)-32(ion )0.6(2024 )0.5(Mar)-32(ch )0.6(07]. )0.6(Newsle)-12(t)-30(ter; )0.6(2025. )]TJ 0.014 Tc 0.506 Tw T* [(\212\024\f\021\031\023\027\024 \023\024: ht)-29.8(tps://www.who.int/r)-21.8(u/news-r)-31.8(o)-15.8(om/f)16.3(a)-16.8(c)-15.8(t-shee)-11.8(ts/)]TJ 0 Tc 0.299 Tw T* [(de)-12(t)15(ail/diar)-23.9(r)-24(hoeal-disease. \222\f\t\035\022\026 \026\022\021\017\r\027\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC [(01.07.2025/ W)20(or)-30(ld )]TJ -0.01 Tw T* [(Heal)56(t)-12.9(h Or)-32(ganiza)15.1(t)-32(ion. Diar)-24(r)-24(hea [c)-23.9(i)-24(ted 2024 Mar 07]. F)20(a)-17(c)-16(t shee)-12(t; 2025. )]TJ 0.002 Tc 0.349 Tw T* [(A)15.6(v)-14.5(a)0.6(i)0.6(l)-15.5(a)0.6(b)0.5(l)0.6(e)0.5(:)0.6( h)0.5(t)-29.4(t)0.6(p)0.5(s)0.6(:)0.5(/)0.6(/)0.5(w)0.6(w)0.6(w)0.5(.)0.6(w)0.5(h)0.6(o)0.5(.)0.6(i)0.6(n)0.5(t)0.6(/)0.5(r)-21.4(u)0.6(/)0.5(n)0.6(e)0.5(w)0.6(s)0.6(-)0.5(r)-31.4(o)-15.5(o)0.6(m)0.5(/)0.6(f)16.5(a)-16.4(c)-15.4(t)0.5(-)0.6(s)0.5(h)0.6(e)0.6(e)-11.5(t)0.6(s)0.5(/)0.6(d)0.5(e)-11.4(t)15.6(a)0.5(i)0.6(l)0.5(/)]TJ 0 Tc 0.023 Tw T* [(diar)-24(r)-23.9(hoeal-disease. 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R)13.2(esul)56.2(ts of)]TJ /Span<>> BDC ( )Tj EMC [(enhanced r)-23.8(ecover)-23.8(y af)-27.8(ter sur)-31.8(ger)-23.8(y \(ERA)35.2(S\) in)11( )]TJ -0.011 Tw T* [(\fol)29.8(op)24.8(r)-32.2(o)-16.1(c)-16.2(t)16.8(ol)29.8(o)-16.2(g)15.8(y. )]TJ /T1_2 1 Tf 7.091 0 Td [(K)17.8(olop)45.8(roktologia)]TJ /T1_1 1 Tf 0.416 Tw [(. )0.5(2018;2\(64\):32\22638. )0.6(\(in )0.5(Russ.\).)11( )]TJ 0 Tc 0 Tw -7.091 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2018-0-2-32-38)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.4645 56.0378 Tm (133)Tj ET endstream endobj 716 0 obj <>/Border[0 0 0]/H/N/Rect[233.71 467.909 263.622 458.453]/Subtype/Link/Type/Annot>> endobj 717 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 457.909 121.288 448.613]/Subtype/Link/Type/Annot>> endobj 718 0 obj <>/Border[0 0 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(\024\002\027\026\030\031\032\036\027\027\024\005 \027\036\024\007\027\024\ \030\024\007\027\024\f\021\017 \020\030\031\023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \023\030\017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.198 Tw 0 -1.218 TD [(\027\026\022\024\r )0.6(\002\t\035 )0.5(\023\030\024\r\036\007\036\027 )0.5(\030\036\020\030\036\f\f\017\024\027\027\t\005 )0.5(\026\027\026\035\017. )0.5(\210\027)24( )]TJ 0.022 Tw T* (\023\024\022\026\026\035, \004\021\024 \024\002\255\036\n \024\023\036\030\ \026\006\017\017 \027\036 \016\r\035\016\035\f\016 \f\021\026\021\017\f\021\ \017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.115 Tw T* [(\004\036\f\022\017 \027\026\004\017\n\t\n \235\026\022\021\024\030\024\n\ \030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\005.)24( )]TJ 0.185 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016 \022\035\033\004\036\r\t\n\017 \023\030\ \036\007\017\022\021\024\030\026\n\017, \027\026\004\017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc -0.011 Tw T* (\021\036\035\034\027\024 \031\r\036\035\017\004\017\r\026\033\013\017\n\017\ \r\036\030\024\016\021\027\024\f\021\034 \030\026\r\017\021\017\016 \024\ \f)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.115 Tw 0 -1.218 TD (\035\024\032\027\036\027\017\005, \f\021\026\035\017 \235\024\030\n\017\030\ \024\r\026\027\017\036 \026\027\026\f\021\024\n\024\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc -0.011 Tw 0 -1.218 TD (\n\024\013\034\033 \f\001\017\r\026\033\013\017\b \026\023\023\026\030\026\ \021\024\r \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(9,48; 95% \212\230:)24( )]TJ -0.024 Tw 0 -1.218 TD (1,88\22657,66; )Tj /T1_1 1 Tf 0 Tc 0 Tw 5.3 0 Td (p)Tj /T1_0 1 Tf 0.024 Tc 0.042 Tw /Span<>> BDC 0.502 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\005 pN2 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3,63;)24( )]TJ 0.138 Tw -5.802 -1.218 Td (95% \212\230: 1,11\22612,34; )Tj /T1_1 1 Tf 0 Tc 0 Tw (p)Tj /T1_0 1 Tf 0.024 Tc 0.138 Tw /Span<>> BDC 10.109 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,01\). \200\024\030\026\f\021 \023\026\006\017\036\027\021\026)24( )]TJ 0.029 Tw -10.109 -1.218 Td (\021\026\022 \032\036 \002\t\035 \r\026\032\027\t\n \235\026\022\021\024\ \030\024\n, \023\024\r\t\001\026\033\013\017\n \r\036\030\024)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.183 Tw T* (\016\021\027\024\f\021\034 \030\026\r\017\021\017\016 \024\f\035\024\032\ \027\036\027\017\005, \024\007\027\026\022\024 \036\020\024 \f\021\026\021\ \017)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.201 Tw T* (\f\021\017\004\036\f\022\026\016 \027\026\004\017\n\024\f\021\034 \017\n\ \036\035\026 \023\024\020\030\026\027\017\004\027\024\036 \027\026\004\036\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc -0.047 Tw T* (\027\017\036 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,06; 95% \212\230: 1,00\2261,14; )Tj /T1_1 1 Tf 0 Tc 0 Tw (p)Tj /T1_0 1 Tf 0.024 Tc -0.047 Tw /Span<>> BDC 15.891 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,07\). \221\026\022\017\n)24( )]TJ 0.018 Tw -15.891 -1.218 Td [(\024\002\030\026\024\n, \002\t\035\024 )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.5(\004\021\024 )0.6(\027\026\002\035\033\007\026\036\n\026\016 )0.6(\030\026)]TJ 0 Tc 0 Tw (-)Tj 0.024 Tc 0.039 Tw T* [(\027\017\006\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.185 0 Td [(\004\026\f\021\024\021\036 )0.5(\030\026\r\017\021\017\016 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.5(\024\002\031\f\035\024\r\035\036\027\026)24( )]TJ 0.055 Tw -3.185 -1.218 Td (\027\036 \024\002\255\036\n\024\n \030\036\036\022\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\n\017 \b\026\030\026\022\021\036\030\017\f\021\017\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.014 Tw T* (\022\026\n\017 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\017\n\017 \026\f\023\036\022\021\026\n\017\ \r\t\023\024\035)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc T* (\027\036\027\027\t\b \024\023\036\030\026\006\017\005.)Tj 0 Tc 0.17 Tw T* (\203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036\027\017\036 \002\024\035\034\001\036\020\024 \004\017\ \f\035\026 \035\017\n\235\024\031\035\024\r )Tj 0.277 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\b \030\036\036\022\006\017\016\b \023\ \024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\020)Tj 0 Tw (-)Tj 0.078 Tw T* (\n\036\027\021\026\030\027\t\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 29 \(21;48\) \023\030\024\021\017\r 20 \(15,7;32,2\), \f\024)Tj 0 Tw (-)Tj 0.204 Tw T* (\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.204 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005\), \004\026\f\021\024\021\026 \n\036\021\026\f\021\026\021\017\004\ \036\f\022\024\020\024 )Tj 0.291 Tw T* [(\023\024\030\026\032\036\027\017\016 \035\017\n\235\024\031\035\024\r )0.5(\024\022\026\026\035\026\f\034 \f\024\023\024\f\021\026\r\017\n\026)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.024 Tw -21.11 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (19)Tj /Span<>> BDC ( )Tj EMC (\(34,5%\) \027\026\002\035\033\007\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\r 15 \(48,4%\) )Tj 0 Tw T* (\f\035\031\004\026\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\).)Tj 0.098 Tw T* (\200 \f\r\024\033 \024\004\036\030\036\007\034, \026\027\026\035\017 \024\ \021\007\026\035\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r\ \035\036)Tj 0 Tw (-)Tj 0.288 Tw T* [(\004\036\027\017\016 )0.5(\023\024\022\026\026\035, )0.5(\004\021\024 )0.5(5-\035\036\021\027\016\016 )0.6(\024\002\013\026\016 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )]TJ 0.236 Tw T* (\f\024\f\021\026\r\017\035\026 86% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (78,3%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.108 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.108 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,69\), \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024)Tj 0 Tw (-)Tj 0.435 Tw T* (\021\026 \r\t\016\r\035\036\027\027\t\b \024\021\007\026\035\036\027\027\ \t\b \n\036\021\026\f\021\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 10,9% )Tj 0.227 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (10,7%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.227 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \221\026\022\017\n \024\002\030\026\024\n, )Tj 0.209 Tw T* (\024\021\f\031\021\f\021\r\017\036 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.161 Tw T* [(\007\026\035\036\027\027\t\b \030\036\031\035\034\021\026\021\026\b )0.5(\023\024\r\024\035\016\036\021 \023\030\036\007\023\024\035\024\032\017\ \021\034, \004\021\024 )]TJ -0.037 Tw T* (\035\017\n\235\024\007\017\f\f\036\022\006\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \f\030\036\007\027\017\b \024\002\024\007\024\004\027\t\b\ \f\024\f\031\007\024\r )Tj 0.231 Tw T* (\007\024\f\021\026\021\024\004\027\026 \007\035\016 \024\023\031\b\024\035\ \036\005, \035\024\022\026\035\017\031\033\013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007)Tj 0 Tw (-)Tj 0.148 Tw T* (\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\004\027\024\005\ \024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021)Tj 0 Tw (-)Tj 0.634 Tw T* (\f\021\r\017\017 \022\035\017\027\017\004\036\f\022\017\b \023\030\017\027\ \026\022\024\r \n\036\021\026\f\021\026\017\030\024\r\026\027\017\016 )Tj 0.148 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t \002\030\t\032\036\005\022\017 \023\030\026\ \r\t\b \024\021\007\036\035\024\r \024\002\024\007\024\004\027\024\005 )Tj 0.195 Tw T* (\022\017\001\022\017. \211\007\026\035\036\027\017\036 \002\030\t\032\036\ \005\022\017 \023\030\026\r\024\005 \023\024\035\024\r\017\027\t \024\002\ \024)Tj 0 Tw (-)Tj 0.267 Tw T* [(\007\024\004\027\024\005 )0.5(\022\017\001\022\017 \f)]TJ /Span<>> BDC ( )Tj EMC [(\035\017\n\235\024\031\035\026\n\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\b\024\007\036 )0.5(\r\t\023\024\035\027\036\027\017\016 )]TJ 0.099 Tw T* (\030\026\f\001\017\030\036\027\027\t\b \r\n\036\001\026\021\036\035\034\f\ \021\r \027\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \035\024 )Tj 0.325 Tw T* (\031\035\031\004\001\036\027\017\016 \023\024\022\026\026\021\036\035\036\ \005 \r\t\032\017\r\026\036\n\024\f\021\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.215 Tw T* [(\027\017\033 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 3.036 0 Td [(\f\036\020\n\036\027\021\026\030\027\024\005 )0.6(\030\036\036\022\006\017\036\005. )0.5(\210\007\027\026\022\024 )0.6(\024\021\f\031\021\f\021\r\017\036 )]TJ 0.139 Tw -3.036 -1.218 Td (\030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\032\017\r\026\036\n\024\f\021\017 \n\024\032\036\021 \002\t\021\034\ \024\002\031\f\035\024\r\035\036\027\024 )Tj 0.059 Tw T* (\021\026\022\032\036 \024\021\027\024\f\017\021\036\035\034\027\024 \027\ \036\002\024\035\034\001\017\n \023\030\036\024\002\035\026\007\026\027\017\ \036\n \024\023\031)Tj 0 Tw (-)Tj 0.103 Tw T* (\b\024\035\036\005 \030\026\027\027\017\b \f\021\026\007\017\005. \200)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\030\026\f)Tj 0 Tw (-)Tj 0.03 Tw T* (\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (63,6% \017)Tj /Span<>> BDC ( )Tj EMC (51,6% \027\026\002\035\033\007\036\027\017\005, )Tj 0.198 Tw 23.244 64.543 Td (\f\024\024\021\r\036\021\f\021\r\036\027\027\024, \027\036 \002\t\035\024\ \n\036\021\026\f\021\026\021\017\004\036\f\022\024\020\024 \023\024\030\ \026\032\036)Tj 0 Tw (-)Tj T* (\027\017\016 \035\017\n\235\024\031\035\024\r.)Tj 0.132 Tw T* (\221\026\022\032\036 \r\026\032\027\t\n \026\f\023\036\022\021\024\n \024\ \006\036\027\022\017 \220\235\235\036\022\021\017\r\027\024\f\021\017 \b\ \017)Tj 0 Tw (-)Tj 0.043 Tw T* (\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016\ \016\r\035\016\036\021\f\016 \f\024\b\030\026\027\036\027\017\036 \022\026\ \004\036\f\021\r\026 )Tj 0.142 Tw T* (\032\017\027\017 \002\024\035\034\027\t\b. \210\023\030\024\f \002\024\035\ \034\027\t\b, \023\030\024\r\036\007\036\027\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.194 Tw T* (\007\026\035\036\027\027\t\036 \f\030\024\022\017 \023\024\f\035\036 \r\n\ \036\001\026\021\036\035\034\f\021\r\026, \023\024\022\026\026\035, \004\ \021\024 )Tj -0.022 Tw 0 -1.218 TD (\004\026\f\021\024\021\026 \007\036\235\036\022\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\036 \030\026\035\017\004\026\035\026\f\034\ \(2 \030\026\026/)Tj 0.035 Tw 0 -1.218 TD [(\f\031\021\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.25 0 Td [(\024\002\036\017\b )0.5(\020\030\031\023\023\026\b, )]TJ /T1_1 1 Tf 0 Tw 6.381 0 Td (p)Tj /T1_0 1 Tf 0.035 Tw /Span<>> BDC ( )Tj EMC 0.745 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.767 0 Td [(0,97\), )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 3.238 0 Td [(\235\024\030\n\026 )0.5(\022\026\035\026 )0.6(5 )0.5(\021\017\023\026 )]TJ 0.043 Tw -14.382 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\001\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\036 \027\036\ \002\t\035\026 \024\021\n\036\004\036\027\026 \027\017 )Tj -0.019 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\020\024 \002\024\035\034\027\024\020\024, \004\021\024 \ \024\023\030\024\r\036\030\020\026\036\021 \024\023\026\f\036\027\017\016\ \027\036\022\024\021\024)Tj 0 Tw (-)Tj 0.093 Tw T* (\030\t\b \b\017\030\031\030\020\024\r \024)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\024\n \030\017\f\022\036 \030\026\r\017\021\017\016 )0.5(\007\017\026\030\036\017 \023\024)]TJ 0 Tw (-)Tj T* (\f\035\036 \030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\ \017\017 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017.)Tj 0.198 Tw 0 -1.218 TD (\215\024\035\031\004\036\027\027\t\036 \027\026\n\017 \007\026\027\027\t\ \036 \035\017\n\017\021\017\030\024\r\026\027\t \024\020\030\026\027\017\ \004\036)Tj 0 Tw (-)Tj 0.152 Tw 0 -1.218 TD [(\027\017\016\n\017 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016, )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\t\n \n\024\032\027\024 \024\021\027\036\f\021\017 )0.5(\036\020\024 )]TJ 0.001 Tw 0 -1.218 TD (\030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 \b\026\030\026\022\ \021\036\030, \024\021\027\024\f\017\021\036\035\034\027\024 \027\036\002\ \024\035\034\001\031\033 )Tj 0.058 Tw T* (\r\t\002\024\030\022\031 \023\026\006\017\036\027\021\024\r \()Tj /T1_1 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (86\), \024\021\f\031\021\f\021\r\017\036 \036\007\017\027\t\b \023\030\024\ )Tj 0 Tw (-)Tj 0.109 Tw T* (\021\024\022\024\035\024\r \r\036\007\036\027\017\016 \002\024\035\034\027\ \t\b, \r\t\002\024\030\026 \024\002\255\036\n\026 \024\023\036\030\026\006\ \017\017 )Tj 0.218 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\026 \035\017\n\235\024\007\017\f\f\036\022\006\017\017\ , \004\021\024 \n\024\020\035\024 \f\031\013\036\f\021\r\036\027\027\024\ )Tj 0.072 Tw T* (\023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\t. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \022\024\027\021\036\022\f\021\036 \017\f\023\024\035\034\ \024)Tj 0 Tw (-)Tj T* [(\r\026\027\017\036 \215\030\024\020\030\026\n\n\t \031\f\022\024\030\036\ \027\027\024\020\024 )0.5(\r\t\007\024\030\024\r\035\036\027\017\016 )0.5(\n\024\020\035\024 )]TJ 0.175 Tw T* (\002\t \024\002\036\f\023\036\004\017\021\034 \f\021\026\027\007\026\030\ \021\017\026\006\017\033 \023\036\030\017\024\023\036\030\026\006\017\024\ \027\027\024\020\024 )Tj 0.265 Tw T* (\r\036\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\235\017\006\017\030\024\r\026\021\034 \036\020\024 \r\035\017\ \016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\t )Tj 0.262 Tw T* (\035\036\004\036\027\017\016 [12]. \003\027\026\004\017\021\036\035\034\027\ \t\n \024\020\030\026\027\017\004\036\027\017\036\n \030\026\002\024\021\ \t )Tj 0.044 Tw T* (\021\026\022\032\036 \016\r\035\016\036\021\f\016 \023\024\021\036\030\016\ \007\026\027\027\t\b 12)Tj /Span<>> BDC ( )Tj EMC (\(13,9%\) \023\026\006\017\036\027\021\024\r )Tj 0.242 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \024\021\007\026\035\036\027\027\t\b \030\036\031\ \035\034\021\026\021\024\r, \023\024\021\036\027\006\017\026\035\034\027\ \024 )Tj -0.03 Tw T* (\n\026\f\022\017\030\031\016 \030\026\035\017\004\017\016 \n\036\032\007\ \031 \020\030\031\023\023\026\n\017. \025\030\024\n\036 \021\024\020\024\ , \007\035\017)Tj 0 Tw (-)Tj 0.092 Tw T* (\021\036\035\034\027\024\f\021\034 \027\026\002\035\033\007\036\027\017\016\ \(\204\036)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (52 \(34,7; 68,5\) \n\036\f\016\006\026\) )Tj 0.032 Tw T* (\n\024\032\036\021 \002\t\021\034 \027\036\007\024\f\021\026\021\024\004\ \027\024\005 \007\035\016 \024\006\036\027\022\017 \r\f\036\b \024\021\007\ \026\035\036\027)Tj 0 Tw (-)Tj 0.115 Tw T* (\027\t\b \017\f\b\024\007\024\r. \212\035\016 \r\036\030\017\235\017\022\ \026\006\017\017 \023\024\035\031\004\036\027\027\t\b \007\026\027\027\t\ \b )Tj 0.031 Tw T* (\027\036\024\002\b\024\007\017\n\t \023\030\024\f\023\036\022\021\017\r\027\ \t\036 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\036 \017\f\ )Tj 0 Tw (-)Tj 0.07 Tw T* (\f\035\036\007\024\r\026\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 \027\036\023\024\f\030\036\007\f\021\r\036\027\ \027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.148 Tw T* (\027\t\b \030\036\031\035\034\021\026\021\024\r \024\023\036\030\026\006\ \017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \022\026\004\036\f\021\r\026 \032\017\027\017 )Tj 0 Tw T* (\002\024\035\034\027\t\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 298.5998 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.702 Tw 10 0 0 10 303.3071 274.2438 Tm (\215\030\024\r\036\007\036\027\027\024\036 \017\f\f\035\036\007\024\r\026\ \027\017\036 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\ \024, )Tj -0.043 Tw T* (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\ \036\036\022\006\017\017 \023\024\023\036\030\036\004\027\024\005 \024\002\ \024)Tj 0 Tw (-)Tj 0.072 Tw T* (\007\024\004\027\024\005 \022\017\001\022\017 \004\026\f\021\024\021\026\ \030\026\r\017\021\017\016 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\t\b )Tj 0.032 Tw T* (\024\f\035\024\032\027\036\027\017\005 \027\017\032\036, \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\t\b \030\036\ \036\022)Tj 0 Tw (-)Tj 0.189 Tw T* (\006\017\005. \200)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \030\036\020\030\036\f\f\017\024\027\027\024\020\024 \026\ \027\026\035\017\026 \002\t\035\024 \024\002\027\026\030\031)Tj 0 Tw (-)Tj 0.118 Tw T* (\032\036\027\024, \004\021\024 \024\002\255\036\n \024\023\036\030\026\006\ \017\017 \027\036 \016\r\035\016\035\f\016 \027\036\026\r\017\f\017\n\t\ \n )Tj 0.135 Tw T* (\023\030\036\007\017\022\021\024\030\024\n \030\026\r\017\021\017\016 \024\ \f\035\024\032\027\036\027\017\005. \200\036\030\024\016\021\027\024\f\021\ \034 \017\b )Tj -0.04 Tw T* [(\030\026\r\017\021\017\016 )0.5(\023\024\r\t\001\026\035\024 \017\f\023\024\035\034\024\r\026\027\017\036\ )0.5(\f\001\017\r\026\033\013\017\b )0.5(\026\023\023\026)]TJ 0 Tw (-)Tj 0.054 Tw T* (\030\026\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \n\036\032\022\017\001\036\004\ \027\024\020\024 \026\027\026\f\021\024\n\024\026 )Tj -0.001 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\005 pN2. \210\021\007\026\035\036\027\027\t\ \036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\036 )Tj 0 Tw T* (\030\026\035\017\004\026\035\017\f\034.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.399 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.8(:)]TJ /T1_1 1 Tf -0.029 Tc 0.428 Tw [( \205)-1.4(\r)-19.8(\213)-21.8(\n)-19.1(\031)-19.5(\021)]TJ /Span<>> BDC 19.624 0 Td ( )Tj EMC [(\217)-1.4(.\002.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -19.624 -1.218 Td [(\205)17.6(\r)-14.3(\032)-9.9(\031\021)-10.7(\027)-9.4(\b\022)-2.8(\025)]TJ /Span<>> BDC 4.077 0 Td ( )Tj EMC [(\036)12.8(.)33.7(\205)-12(.)-2.2(,)-10( \225)6.6(\031)-7.6(\026)-1.2(\t)0.8(\n\031\021)]TJ /Span<>> BDC 5.436 0 Td ( )Tj EMC [(\036)12.8(.)-2.7(\003)-12.2(.)]TJ /T1_0 1 Tf 0 Tc 0.81 Tw -9.513 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_1 1 Tf -0.029 Tc 0.839 Tw [( \237)-14.9(\020)-20.3(\021)-35.6(\f)-20(\020)-28.1(\027)-22.4(\021)]TJ /Span<>> BDC 19.299 0 Td ( )Tj EMC [(\002.\206)65(.)-21.2(,)-29.1( )]TJ 0 Tc 0 Tw -19.299 -1.218 Td [(\221)3.8(\f)-0.9(\r)7.1(\030)1.9(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.4(.)43.7(\217)27.6(.)7.8(, \036)-7.6(\f)3.4(\203)5.4(\022)4.7(\026)4(\031)9.6(\021)2.1(\020)]TJ /Span<>> BDC ( )Tj EMC [(\224)26.6(.)7.3(\003)-2.3(.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (132)Tj ET endstream endobj 704 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.028 Tw 10 0 0 10 274.9606 298.5999 Tm (\212\036\235\036\022\026\006\017\016 3 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017, \004\021\024 \n\024\032\036\021 \f\024\024\021\r\036\ \021)Tj 0 Tw (-)Tj 0.249 Tw 0 -1.218 TD [(\f\021\r\024\r\026\021\034 \024\023\030\036\007\036\035\036\027\017\033 \ )0.5(\253\007\017\026\030\036\016\273, \002\t\035\026 \026\030\036\020\017\f\ \021\030\017)]TJ 0 Tw (-)Tj 0.202 Tw T* (\030\024\r\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (3/28 \(10,7%\) \027\026\002\035\033\007\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f)Tj 0 Tw (-)Tj 0.019 Tw T* (\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\031 1/46 \(1,82%\) \023\026\006\017\036\027\021\026 \023\024\f\035\036 \ )Tj 0.091 Tw T* (\f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022\006\017\017\ [11]. \215\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \023\026\030\026\n\036\021\030\031 )Tj 0.039 Tw T* (\020\030\031\023\023\t \002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t\ \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.039 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,1\). \211)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\020\024 )Tj 0.047 Tw T* [(\002\024\035\034\001\017\027\f\021\r\026 )0.6(\002\024\035\034\027\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.178 0 Td [(\020\030\031\023\023\026\b )0.5(\022\026\035 )0.6(\017\n\036\035 )0.5(\235\024\030\n\031, )0.5(\f\024)]TJ 0 Tw (-)Tj -0.014 Tw -10.178 -1.218 Td (\024\021\r\036\021\f\021\r\031\033\013\026\016 \021\017\023\031 3 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\036. \222\021\ \031\035 5, )Tj 0.102 Tw T* (6 \017)Tj /Span<>> BDC ( )Tj EMC (7 \021\017\023\026, \b\026\030\026\022\021\036\030\027\t\005 \007\035\016\ \007\017\026\030\036\017, \002\024\035\034\027\t\036 \024\002\036\017\b\ )Tj 0 Tw T* (\020\030\031\023\023 \027\036 \024\021\n\036\004\026\035\017 \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 152.4639 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.024 Tc 0.264 Tw 10 0 0 10 274.9606 128.1078 Tm (\215\030\024\r\036\007\036\027\027\024\036 \017\f\f\035\036\007\024\r\026\ \027\017\036 \r\t\016\r\017\035\024 \f\021\026\021\017\f\021\017\004\036\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.069 Tw T* (\f\022\017 \027\026\004\017\n\024\036 \f\027\017\032\036\027\017\036 \024\ \002\013\036\005 \004\026\f\021\024\021\t \023\024\f\035\036\024\023\036\ )Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.146 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022)Tj 0 Tc 0 Tw (-)Tj 0.024 Tc 0.154 Tw T* (\006\017\017 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\033)24( )]TJ 0.066 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\n\017 \r\n\036\001\026\021\036\035\034\ \f\021\r\026\n\017)Tj /Span<>> BDC ( )Tj EMC [(\227 20% \023\030\024\021\017\r)24( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\b\032\027\024\024\022\031\025\025\013\235 \020\025\020\f\022\016\ \033\032\027\030\022\n\023\031\032\031\021 \032\020\016\021\022\023\022\ \t \031\024\f\031\255\025\027\025\022\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.323 0 Td [( R)2.8(e)-7.7(g)-1.5(r)-1.9(e)-22.1(s)-10.4(s)-12.5(i)-1.4(o)-4(n a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-2.8(r)-2(e)-12.9(d)-3(i)-1.7(c)-32.4(t)-3(o)-3(r)-14.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-4.9(li)-1.8(c)3.2(a)-9.1(t)-29.1(i)-1.4(o)-4(n)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 703.7118 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 201.5098 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 348.9114 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 496.313 703.9618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 201.2598 703.7118 cm 0 0 m 102.297 0 l S Q q 1 0 0 1 201.5098 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 703.7118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 348.9114 703.7118 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 703.7118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 692.2426 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 692.2426 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 692.2426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 692.2426 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 692.2426 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7813 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 680.7813 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 680.7813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 680.7813 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 680.7813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.57 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.32 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 669.32 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 669.32 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 669.32 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 669.32 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1088 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8588 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 657.8588 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 657.8588 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 657.8588 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 657.8588 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6475 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.3975 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 646.3975 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 646.3975 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 646.3975 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 646.3975 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.1862 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.9362 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 634.9362 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 634.9362 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 634.9362 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 634.9362 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 623.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 623.4749 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 623.4749 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 623.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 623.4749 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 623.4749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 612.2636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 612.0136 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 612.0136 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 612.0136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 612.0136 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 612.0136 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 600.8023 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 600.5523 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 600.5523 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 600.5523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 600.5523 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 600.5523 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 589.3411 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 589.0911 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 589.0911 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 589.0911 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 589.0911 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 589.0911 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 577.8798 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 577.6298 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 201.5098 577.6298 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 201.5098 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 577.6298 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 303.5571 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 577.6298 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 348.9114 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 577.6298 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.4185 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.1685 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 201.5098 566.1685 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 303.5571 566.1685 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 348.9114 566.1685 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 450.9586 566.1685 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 102.5001 700.8118 Tm (\200\004\006\004\214\r\003\006\013)Tj 16.478 0.717 Td (\222\b\t\004\006\t\004\b\003\b\013\005 \004\b\004\f\t\213)Tj 17.657 0 Td (\215\210\f\001\003\t\004\006\t\004\b\003\b\013\005 \004\b\004\f\t\213)Tj -18.381 -1.434 Td (\017\016 \(95% \031\034\))Tj /T1_5 1 Tf 11.953 0.001 Td (\t)Tj /T1_4 1 Tf 6.473 -0.001 Td (\017\016 \(95% \031\034\))Tj /T1_5 1 Tf 11.953 0.001 Td (\t)Tj /T1_1 1 Tf -53.244 -1.433 Td (\200\024\030\026\f\021)Tj 22.574 0 Td (1,05)Tj /Span<>> BDC ( )Tj EMC (\(0,99\2261,12\))Tj 11.662 0 Td (0,07)Tj 7.356 0 Td (1,06)Tj /Span<>> BDC ( )Tj EMC (\(1\2261,14\))Tj 11.07 0 Td (0,07)Tj -52.661 -1.433 Td (\215\024\035 \(\n\031\032\f\022\024\005\))Tj 22.824 0 Td (0,76)Tj /Span<>> BDC ( )Tj EMC (\(0,24\2262,2\))Tj 11.662 0 Td (0,6)Tj -34.486 -1.433 Td (\230\027\007\036\022\f \n\026\f\f\t \021\036\035\026)Tj 22.574 0 Td (0,97)Tj /Span<>> BDC ( )Tj EMC (\(0,86\2261,09\))Tj 11.662 0 Td (0,63)Tj -34.236 -1.433 Td (ASA II/III)Tj 22.574 0 Td (0,67)Tj /Span<>> BDC ( )Tj EMC (\(0,23\2261,90\))Tj 11.662 0 Td (0,45)Tj -34.236 -1.433 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005 \007\024\ \f\021\031\023)Tj 22.574 0 Td (1,12)Tj /Span<>> BDC ( )Tj EMC (\(0,35\2263,30\))Tj 11.662 0 Td (0,84)Tj -34.236 -1.433 Td (\025\030\024\r\024\023\024\021\036\030\016)Tj 23.167 0 Td (0,99)Tj /Span<>> BDC ( )Tj EMC (\(0,99\2261\))Tj 11.07 0 Td (0,63)Tj -34.236 -1.433 Td (\202\023\023\026\030\026\021\027\t\005 \026\027\026\f\021\024\n\024)Tj 22.324 0 Td (8,33)Tj /Span<>> BDC ( )Tj EMC (\(1,82\22644,92\))Tj 11.662 0 Td (0,007)Tj 6.763 0 Td (9,48)Tj /Span<>> BDC ( )Tj EMC (\(1,88\22657,66\))Tj 11.662 0 Td (0,008)Tj -52.411 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017)Tj 23.167 0 Td (0,99)Tj /Span<>> BDC ( )Tj EMC (\(0,98\2261\))Tj 11.07 0 Td (0,63)Tj -34.236 -1.433 Td (\030N2)Tj 22.324 0 Td (3,53)Tj /Span<>> BDC ( )Tj EMC (\(1,19\22610,69\))Tj 11.912 0 Td (0,02)Tj 6.513 0 Td (3,63)Tj /Span<>> BDC ( )Tj EMC (\(1,11\22612,34\))Tj 11.912 0 Td (0,03)Tj -52.661 -1.433 Td (\030\2214b)Tj 22.759 0 Td (3,2)Tj /Span<>> BDC ( )Tj EMC (\(0,58\22616,05)Tj 11.477 0 Td (0,15)Tj -34.236 -1.433 Td (\217\026\f\001\017\030\036\027\027\026\016 \030\036\036\022\006\017\016\ \024\002\024\007\024\004\027\024\005 \022\017\001\022\017)Tj 22.824 0 Td (2,8)Tj /Span<>> BDC ( )Tj EMC (\(0,97\2268,33\))Tj 11.412 0 Td (0,11)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 549.4492 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\023\030\020\f\027\025\025\013\027 \032\027\016\r\f\017\023\020\023\ \013 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.002 Tc -0.002 Tw 3.329 0 Td [( L)-7.7(o)-2(n)1.4(g)-11.7(-)-7.4(te)-3.9(r)-16.6(m)2( re)-20(s)8.7(ul)7.3(t)-30.9(s)2( i)5.9(n)2( g)0.5(ro)-1.4(up)3.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 534.1472 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 534.1472 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 534.1472 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 534.1472 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 522.928 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 522.678 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 522.678 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 522.678 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 522.678 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 511.4588 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 511.2088 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 511.2088 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 511.2088 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 511.2088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 499.9975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 499.7475 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 499.7475 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 499.7475 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 499.7475 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 488.5362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 488.2862 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 488.2862 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 488.2862 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 488.2862 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 477.0749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 476.8249 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 476.8249 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 476.8249 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 476.8249 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 465.6136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 465.3636 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 224.187 465.3636 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 465.3636 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 450.9586 465.3636 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 8 0 0 8 116.7386 525.5126 Tm (\200\004\006\004\214\r\003\006)Tj 15.36 0 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 14.227 0 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj /T1_5 1 Tf 14.766 0.001 Td (\t)Tj /T1_4 1 Tf -53.244 -1.434 Td (\200\006\002\217\f\r\202\r\b\002 \206\002\f\001\b\013\216, )Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf ( \(%\))Tj 27.311 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(83,6\))Tj 14.173 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(90,3\))Tj /T1_1 1 Tf 10.677 0.001 Td (0,52**)Tj -52.161 -1.434 Td (\202\007\255\033\r\026\027\021\027\026\016 \b\017\n\017\024\021\036\030\026\ \023\017\016, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 27.201 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(52,8%\))Tj 14.173 0 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(64,3%\))Tj 10.787 0 Td (0,34**)Tj -52.161 -1.433 Td (\215\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\016, \204\036\ \(Q1; Q3\))Tj 26.808 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(41; 79,5\))Tj 13.488 0 Td (41,5)Tj /Span<>> BDC ( )Tj EMC (\(28,5; 64,7\))Tj 11.865 0 Td (0,08**)Tj -52.161 -1.433 Td (\210\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 27.451 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10,9%\))Tj 14.173 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\))Tj 11.037 0 Td (1,0*)Tj -52.661 -1.433 Td (5-\035\036\021\027\016\016 \210\200, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 28.53 0 Td (86%)Tj 13.831 0 Td (78,3%)Tj 9.551 0 Td (0,69***)Tj /T1_2 1 Tf 7 0 0 7 42.5197 453.879 Tm (\004\032\022\026\027\007\020\025\022\027: \215)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \020\032\022\203\026\027\023\022\007\027\ \024\n\031\027, SD)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\020\025\030\020\032\023\025\031\027 \031\023\n\f\031\025\027\ \025\022\027; *)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\027\024\023)0.7( \214\022\213\027\032\020; **)]TJ /Span<>> BDC ( )Tj EMC (\227 t-\n\032\022\023\027\032\022\235 \205\023\017\005\030\027\025\023\020\ ; ***)Tj /Span<>> BDC ( )Tj EMC (\227 \f\031\b-\032\020\025\b\031\021\013\235 )Tj 0 -1.2 TD (\023\027\024\023.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 426.1751 Tm (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \024\023\r\f\020 \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.076 Tc 0.076 Tw T* [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.25 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e c)-2.5(ha)-6.2(i)4.9(r i)3.9(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 410.8731 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 410.8731 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 410.8731 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 410.8731 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 410.8731 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 399.6539 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 399.4039 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 184.502 399.4039 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 399.4039 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 399.4039 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 399.4039 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 388.1847 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 387.9347 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 387.9347 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 387.9347 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 387.9347 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 387.9347 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 376.7234 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 376.4734 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 376.4734 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 376.4734 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 376.4734 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 376.4734 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 365.2621 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 365.0121 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 343.9508 cm 0 0 m 0 20.811 l S Q q 1 0 0 1 184.502 365.0121 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 184.502 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 224.187 365.0121 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 365.0121 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9586 365.0121 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 344.2008 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.7697 332.7395 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.252 343.9508 cm 0 0 m 39.935 0 l S Q q 1 0 0 1 184.502 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 343.9508 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 343.9508 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 343.9508 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 332.7395 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 332.4895 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 184.502 332.4895 cm 0 0 m 39.685 0 l S Q q 1 0 0 1 224.187 332.4895 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 332.4895 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 450.9586 332.4895 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 116.7386 402.2385 Tm (\200\004\006\004\214\r\003\006)Tj 15.36 0 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 14.227 0 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235)Tj /T1_5 1 Tf 14.766 0.001 Td (\t)Tj /T1_4 1 Tf -53.244 -1.434 Td (\200\006\002\217\f\r\202\r\b\002 \206\002\f\001\b\013\216, )Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf ( \(%\))Tj 27.311 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(83,6\))Tj 14.173 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(90,3\))Tj /T1_1 1 Tf 10.927 0.001 Td (0,52*)Tj -52.411 -1.434 Td (\232\026\f\021\024\021\026 \f\021\031\035\026, \204\036 \(Q1; Q3\))Tj 28.017 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 14.173 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 10.221 0 Td (1,0**)Tj -52.411 -1.433 Td (\222\021\031\035 3 \030\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 27.451 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,82%\))Tj 14.173 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\))Tj 11.037 0 Td (0,1*)Tj -52.661 -1.433 Td (\221\017\023 \022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 )Tj T* (\001\022\026\035\024\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 19.593 1.2 Td (3)Tj T* (4)Tj 7.608 1.2 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(67,4%\))Tj T* (15)Tj /Span<>> BDC ( )Tj EMC (\(32,6%\))Tj 14.173 1.2 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(71,4%\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(28,6%\))Tj 10.537 1.2 Td (0,80**)Tj -33.097 -2.633 Td (5\2267)Tj 10.095 0 Td (0)Tj 14.173 0 Td (0)Tj 9.893 0 Td (\226)Tj /T1_2 1 Tf 7 0 0 7 42.5197 321.0049 Tm (\004\032\022\026\027\007\020\025\022\027: \215\027)Tj /Span<>> BDC ( )Tj EMC (\227 \026\027\030\022\020\025\020; Q1, Q3)Tj /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023)0.7(\027\024\023 \215\020\025\025\020\231\210)50(\022\023\025\022; ***)]TJ /Span<>> BDC ( )Tj EMC (\227 \250)Tj 4.081 0 0 4.081 381.0127 323.3359 Tm (2)Tj 7 0 0 7 383.0532 321.0049 Tm ( \004\022\032\024\031\025\020.)Tj ET q 42.52 100.97 221.102 179.702 re W n q /GS0 gs 221.1023475 0 0 179.8107056 42.5196833 100.861898 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \202\032\022\021\013\027 \021\013\255\022\021\020\027\026\031\024\023\022\ \202\020\033\f\020\025\020-\215\027\235\027\032\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( K)17(aplan-Meyer sur)-41.9(viv)16(al cur)-41.9(v)13(es)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.6396 56.0378 Tm (131)Tj ET endstream endobj 705 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,w""   !12ASU "#$%&'()*3456789:BCDEFGHIJQRTVWXYZabcdefghijqrstuvwxyz!1A"Qa2qB3r #$%&'()*456789:CDEFGHIJRSTUVWXYZbcdefghijstuvwxyz?0ؾzL>m<,:q]JV59K*}: y1%֓éRMYN Ъ0uEbTUU44m$l.q SX4QCTV*yE`ζ>`ғQEu᪴xJslg[}hgeVTUbSF&%4衴vϜ푩~;M>]-RiiiS\gֽ]wYs3zR*œhĭڦk};I֯5-Ygvxu'KV|XѪ0!?Z'4Zp2®jţ::TE}ޭcvWc)z*vg̵6~e/ER^5GZ濥>.(;j _՟aUY*[sG,-;))CNZyrMX*Bz*r$) ,2XdYie ffrzwpRJXe@Wh㒈H⮳SK$SJXs\jx|V%Y+L:Q)s'Z\Ǐ̼J\чO;XuUTUf&- mCDuҩir%oiJ g٣~g7 Ϫ͚8wzZ:~gpO5 Oc?kXfR$sQI%9f!r,ҭE-@n SEIQS432A,ReSY$,^~%tK5NRzMVjS٩DV54%'RkXڅڐJPѼ)ȴNr8Ҫ0=STҥIj`|3Jy@<,Z*ĢMTWKR4ᦸ4s672Wι,LՓMYkUKiM-5m5]uu VVNyl铞Ce}=Ο4'dO;7Pd1W[faJ0 >׶+)s1E|ԩ^ J畺XS @Ovxu'KV|Y򝴞;j _՟&~DTF| baSrӛl0ұ4Dug("*))!rI)-;PնgRZCz*94SS]tRXo^'Jd@*j&ٜ\CSE$MFMIeE rC 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(\022\030\017\021\036\030\017\016\n N0, N1 \017)Tj /Span<>> BDC ( )Tj EMC (N2 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017)Tj 0 Tw (-)Tj T* (\n\024 \027\036 \030\026\035\017\004\026\035\024\f\034 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.056 Tw T* (\215\024\f\022\024\035\034\022\031 \f\235\024\030\n\017\030\024\r\026\027\ \027\t\036 \r\t\002\024\030\022\017 \002\t\035\017 \027\036\f\024\023\024\ \f)Tj /Span<>> BDC (-)Tj EMC 0.032 Tw T* (\021\026\r\017\n\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\016\007\031 \r\026\032\027\t\b \235\026\022\021\024\030\024\r, \021\ \026\022\017\b \022\026\022 \r\024\030\026\f\021, )Tj 0.197 Tw T* (\017\027\007\036\022\f \022\024\n\024\030\002\017\007\027\024\f\021\017 \ \232\026\030\035\f\024\027\026, \f\023\024\f\024\002 \235\024\030\n\017\030\ \024)Tj 0 Tw (-)Tj 0.032 Tw T* (\r\026\027\017\016 \026\027\026\f\021\024\n\024\026, \007\035\017\021\036\ \035\034\027\024\f\021\034 \024\023\036\030\026\006\017\017, \004\021\024\ \n\024\020\035\024 )Tj 0.051 Tw T* (\024\022\026\t\r\026\021\034 \f\031\013\036\f\021\r\036\027\027\024\036\ \r\035\017\016\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031\004\036\027\027\t\036 \030\036)Tj 0 Tw (-)Tj -0.082 Tw T* (\031\035\034\021\026\021\t, \007\035\016 \002\024\035\036\036 \024\002\255\ \036\022\021\017\r\027\024\005 \024\006\036\027\022\017 \027\026\n\017 \002\ \t\035 \r\t)Tj 0 Tw (-)Tj -0.059 Tw T* (\023\024\035\027\036\027 \030\036\020\030\036\f\f\017\024\027\027\t\005 \ \026\027\026\035\017 \007\026\027\027\t\b, \027\026\023\030\026\r\035\036\ \027\027\t\005 )Tj 0.321 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\036 \023\030\036\007\017\022\021\024\030\024\r\ \030\026\r\017\021\017\016 \024\f\035\024\032\027\036\027\017\005. )Tj 0.1 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 \023\030\024\r\036\007\036\027\027\ \024\020\024 )0.5(\031\027\017\r\026\030\017\026\027\021\027\024\020\024 )0.5(\235\026\022\021\024\030)]TJ 0 Tw (-)Tj 0.098 Tw T* [(\027\024\020\024 )0.5(\026\027\026\035\017\026 )0.6(\017\n\017 )0.5(\024\022\026\026\035\017\f\034: )0.6(\026\023\023\026\030\026\021\027\t\005 )0.6(\026\027\026\f\021\024\n\024 )]TJ 0.071 Tw T* (\(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (8,33; 95% \212\230: 1,82\22644,92; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.071 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\016 )Tj -0.041 Tw T* (pN2 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,53; 95% \212\230: 1,19\22610,69; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \200)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034)Tj 0 Tw (-)Tj 0.226 Tw T* (\021\017\r\026\030\017\026\027\021\027\024\005 \n\024\007\036\035\017 \027\ \036\026\r\017\f\017\n\t\n\017 \023\030\036\007\017\022\021\024\030\026\ \n\017 )Tj 0.285 Tw T* (\024\f\035\024\032\027\036\027\017\005 \024\f\021\026\035\017\f\034 \021\ \036 \032\036 \235\026\022\021\024\030\t: \026\023\023\026\030\026\021\027\ \t\005 )Tj 0.154 Tw T* (\f\023\024\f\024\002 \235\024\030\n\017\030\024\r\026\027\017\016 \026\027\ \026\f\021\024\n\024\026 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9,48; 95% )Tj 0.088 Tw T* (\212\230: 1,88\22657,66; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.088 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\016 pN2 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,63; )Tj 0.087 Tw T* (95% \212\230: 1,11\22612,34; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.087 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \215\024\f\021\030\024\036\027\027\026\016 \n\031\035\034\021\017\ )Tj 0 Tw (-)Tj 0.244 Tw T* (\r\026\030\017\026\027\021\027\026\016 \035\024\020\017\f\021\017\004\036\ \f\022\026\016 \n\024\007\036\035\034 \023\030\017\027\026\027\026 \031\ \f\021\024\005)Tj 0 Tw (-)Tj 0.38 Tw T* (\004\017\r\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \f\024\024\021\r\036\021\f\021\r\031\033\ \013\017\b \022\030\017\021\036\030\017\036\r: )Tj 0.29 Tw 23.244 40.187 Td (\024\021\027\024\001\036\027\017\036 \023\030\026\r\007\024\023\024\007\024\ \002\017\016 \(LR\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (16; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.29 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0011; )Tj 0.183 Tw T* (\022\030\017\021\036\030\017\005 \216\024\f\n\036\030\026\226\214\036\n\036\ \001\024\r\026)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (6,53, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.183 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,5886; R)Tj 0 Tw 5.83 0 0 5.83 521.4944 472.4219 Tm (2 )Tj 0.237 Tw 10 0 0 10 303.3071 456.9139 Tm (\204\026\022\235\026\007\007\036\027\026)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18. \222\035\036\007\031\036\021 \023\024\007\004\036\030\022\027\031\021\ \034, \004\021\024 \030\026\f)Tj 0 Tw (-)Tj 0.498 Tw T* (\001\017\030\036\027\027\t\005 \017\035\017 \f\036\020\n\036\027\021\026\ \030\027\t\005 \b\026\030\026\022\021\036\030 \030\036\036\022\006\017\017\ )Tj 0.285 Tw T* (\027\026\004\017\n\024 \027\036 \r\035\017\016\035 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\035\ \034\021\026)Tj 0 Tw (-)Tj 0.094 Tw T* [(\021\t )0.6(\035\036\004\036\027\017\016 )0.6(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 7.097 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td [(2,8; )0.6(95% )0.5(\212\230: )0.6(0,97\2268,33; )]TJ /T1_1 1 Tf 0 Tw 10.316 0 Td (p)Tj /T1_0 1 Tf 0.094 Tw /Span<>> BDC ( )Tj EMC 0.804 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.826 0 Td (0,11\), )Tj 0 Tw -19.87 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n \031\027\017\r\026\030\017\026\027\021\027\024\020\024\ \026\027\026\035\017\026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.041 Tw T* (\210\021\007\026\035\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t \023\030\024\f\035\036\032\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (46/55 \(83,6%\) )Tj -0.01 Tw T* [(\023\026\006\017\036\027\021\024\r )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.241 0 Td [(\020\030\031\023\023\036 )0.6(\f\036\020\n\036\027\021\026\030\027\024\005 )0.5(\030\036\036\022\006\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 13.759 0 Td [(\031 )0.5(28/31 )]TJ 0.381 Tw -19 -1.218 Td (\(90,3%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022)Tj 0 Tw (-)Tj 0.132 Tw T* (\006\017\017. \215\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\ \016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\005 \020\030\031\023\023\036 \f\024\f\021\026\r\017\035\ )Tj 0.083 Tw T* [(55 )0.5(\(41; )0.5(79,5\) )0.6(\n\036\f\016\006\036\r, )0.5(\r\024 )0.5(\r\021\024\030\024\005)]TJ /Span<>> BDC ( )Tj EMC 14.058 0 Td [(\227 )0.5(41,5 )0.5(\(28,5; )0.6(64,7\) )]TJ 0.194 Tw -14.058 -1.218 Td (\n\036\f\016\006 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.194 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,08\). \202\007\255\033\r\026\027\021\027\026\016 \b\017\n\017\024\021\036\ \030\026\023\017\016 \002\t\035\026 )Tj 0.206 Tw T* (\023\030\024\r\036\007\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (24)Tj /Span<>> BDC ( )Tj EMC (\(52,8%\) \023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\ \001\017\b \222\217 )Tj 0.073 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031 18)Tj /Span<>> BDC ( )Tj EMC (\(64,3%\) \023\026\006\017\036\027\021\024\r, \023\036\030\036\027\036\f\ \001\017\b \217\217 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.073 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34\). )Tj 0.286 Tw T* (\210\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\t \002\t\ \035\017 \r\t\016\r\035\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\(8,7%\) )Tj -0.038 Tw T* (\002\024\035\034\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\031 3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.011 Tw T* (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.011 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \204\036\f\021\027\t\b \030\036\006\017\007\017\r\024\r )Tj 0 Tw T* (\026\002\024\035\036\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\036 \026\235\017\022\f\017\030\024\r\026\ \027\024.)Tj 0.147 Tw T* (\215\030\017 \024\006\036\027\022\036 \024\002\013\036\005 \r\t\032\017\r\ \026\036\n\024\f\021\017 \n\036\007\017\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b )Tj 0.086 Tw T* (\020\030\031\023\023\026\b \027\036 \007\024\f\021\017\020\027\031\021\t\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\004\017\027\036 \n\026\035\024\020\024 \004\017\f\035\026 \f\ \024)Tj 0 Tw (-)Tj 0.094 Tw T* (\002\t\021\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \023\030\036\007\f\021\026\r\035\036\027\026 \007\024\035\ \016 \r\t\032\017\r\001\017\b )Tj 0.103 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\017\030\024\r\026\027\027\t\b \020\024\030\017\024\027\021\ \026\b. \221\026\022, 5-\035\036\021\027\016\016 \210\200 \f\024)Tj 0 Tw (-)Tj 0.17 Tw T* (\f\021\026\r\017\035\026 86%)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (78,3%)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.254 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017, \020\030\031\023\023\t \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n\031 )Tj 0.465 Tw T* [(\023\030\017\027\026\022\031 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )0.5(\027\026\004\017\n\024 \027\036 \030\026\035\017\004\026\035\017\f\034\ )]TJ 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,69\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.495 Tw T* (\230\031\004\036\027\017\036 \004\026\f\021\024\021\t \007\036\235\036\022\ \026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.441 Tw T* (\032\036 \235\024\030\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\017\f\021\036\027\006\017\017 \022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 )Tj 0.073 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\024\005, \023\ \030\024\r\024\007\017\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \021\036)Tj 0 Tw (-)Tj 0.025 Tw T* (\035\036\235\024\027\027\024\020\024 \024\023\030\024\f\026. \207\t\035\024\ \024\002\027\026\030\031\032\036\027\024, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027)Tj 0 Tw (-)Tj 0.188 Tw T* (\027\024\n \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\ \n \023\036\030\017\024\007\036 \007\026\027\027\t\005 \023\026\030\026\n\ \036\021\030 )Tj 0.161 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\036\017\b \020\030\031\023\023\026\b \027\036 \030\026\035\017\ \004\026\035\f\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035 2 \(1; 2\) )Tj 0 Tw T* (\007\036\235\036\022\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,97\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \206\027\016\r\f\017\023\020\023\013 \033\020\023\031\026\031\032\203\031\ \f\031\b\022\007\027\024\n\031\b\031 \022\024\024\f\027\030\031\021\020\025\ \022\t \031\033\027\032\020\006\022\031\025)0.5(\025\013\200 \033\032\027\033\020\032\020\023\031\021 \021)]TJ /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 3.337 0 Td [( R)4.8(e)-20(s)8.7(u)0.5(l)7.2(t)-30.9(s)2.1( o)6(f)]TJ /Span<>> BDC 4.088 0 Td ( )Tj EMC [(t)-8.6(he)2( p)-4.3(a)-7.2(t)-8.6(ho)-1.9(m)-3.3(o)-1(r)-22.3(p)0.9(ho)-3.3(lo)-6.6(g)-16.7(ic)5.3(a)-2.5(l)2( e)-30.4(x)2.5(a)-3.1(m)3.3(i)5.9(n)2.4(a)-7.1(t)-27.1(i)0.6(o)-2(n)2( o)6(f)]TJ /Span<>> BDC 15.91 0 Td ( )Tj EMC [(s)8.7(u)3.6(rg)-16.7(ic)5.2(a)-2.4(l)2( p)-0.8(re)-5.7(p)-4.3(a)-2.2(r)5.3(a)-7.2(t)-27.1(i)0.6(o)-1.9(n)5.7(s)2( i)5.9(n)2( g)0.5(ro)-1.4(up)3.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 715.181 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 391.4311 715.181 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 303.5571 694.1118 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 391.4311 694.1118 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 479.3051 694.1118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 654.1005 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 653.8505 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 303.5571 653.8505 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 391.4311 653.8505 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 479.3051 653.8505 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 524.6594 594.6392 cm 0 0 m 0 58.961 l S Q q 1 0 0 1 70.8661 594.3892 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 594.3892 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 594.3892 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 594.3892 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 583.178 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 582.928 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 582.928 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 582.928 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 582.928 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 571.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 571.4667 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 303.5571 571.4667 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 391.4311 571.4667 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 479.3051 571.4667 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 541.0554 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 540.8054 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 540.8054 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 540.8054 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 540.8054 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 529.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 529.3441 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 71.1161 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 529.3441 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 303.5571 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 391.4311 529.3441 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 529.3441 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 518.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 517.8828 cm 0 0 m 232.691 0 l S Q q 1 0 0 1 303.5571 517.8828 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 391.4311 517.8828 cm 0 0 m 87.874 0 l S Q q 1 0 0 1 479.3051 517.8828 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 8 0 0 8 170.5969 701.7465 Tm (\200\004\006\004\214\r\003\006)Tj -0.04 Tw 16.974 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 0 Tw 3.306 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 7.712 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_3 1 Tf 9.899 0.6 Td (p)Tj /T1_0 1 Tf -53.244 -2.033 Td (\222\021\036\023\036\027\034 \007\017\235\235\036\030\036\027\006\017\030\ \024\r\022\017 \024\023\031\b\024\035\017 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (Grade I)Tj T* (Grade II)Tj T* (Grade III)Tj 31.551 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10,9\))Tj 0.092 -1.2 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(60\))Tj -0.343 -1.2 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(29,1\))Tj 12.563 2.4 Td (0)Tj -1.579 -1.2 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(67,7\))Tj T* (10)Tj /Span<>> BDC ( )Tj EMC (\(32,3\))Tj 9.063 3.6 Td (0,16*)Tj -52.411 -5.033 Td (\206\035\031\002\017\027\026 \017\027\r\026\017\017, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (T1)Tj T* (T2)Tj T* (T3)Tj 0 -1.2 TD (T4a)Tj 0 -1.2 TD (T4b)Tj 31.801 4.8 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,1\))Tj -0.5 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(18,2\))Tj 0 -1.2 TD (18)Tj /Span<>> BDC ( )Tj EMC (\(32,7\))Tj 0 -1.2 TD (19)Tj /Span<>> BDC ( )Tj EMC (\(34,5\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,4\))Tj 12.063 4.8 Td (0)Tj -1.079 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj -0.5 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(35,5\))Tj T* (14)Tj /Span<>> BDC ( )Tj EMC (\(45,2\))Tj 0.25 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(12,9\))Tj 8.313 6 Td (0,15)Tj /T1_1 1 Tf (***)Tj /T1_0 1 Tf -51.911 -7.433 Td (\210\002\013\036\036 \022\024\035\017\004\036\f\021\r\024 \035\017\n\235\ \024\031\035\024\r, \204\036 \(Q1; Q3\))Tj 31.249 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(15,7; 32,2\))Tj 11.669 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(21; 48\))Tj 8.993 0 Td (0,005**)Tj -51.911 -1.433 Td (\025\024\035\017\004\036\f\021\r\024 \n\036\021\026\f\021\026\021\017\004\ \036\f\022\017\b \023\024\030\026\032\036\027\027\t\b \035\017\n\235\024\ \031\035\024\r, \204\036 \(Q1; Q3\))Tj 32.684 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 4\))Tj 10.984 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 4\))Tj 8.493 0 Td (0,49**)Tj -52.161 -1.433 Td (N0 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (N1 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 0 -1.2 TD (N2 )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.984 2.4 Td (35)Tj /Span<>> BDC ( )Tj EMC (\(63,6%\))Tj 0.5 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,1%\))Tj -0.121 -1.2 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(25,4\))Tj 10.605 2.4 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(51,6%\))Tj 0.25 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(16,1%\))Tj -0.25 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(32,3%\))Tj 8.943 2.4 Td (0,44***)Tj -51.911 -3.833 Td (\214\017\n\235\024\r\026\f\022\031\035\016\030\027\026\016 \017\027\r\026\ \017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.984 0 Td (28)Tj /Span<>> BDC ( )Tj EMC (\(50,9%\))Tj 11.364 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(71,0\))Tj 9.063 0 Td (0,11*)Tj -52.411 -1.433 Td (\200\036\027\024\027\026\016 \017\027\r\026\017\016, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 31.984 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(34,5%\))Tj 11.614 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(29,0\))Tj 9.063 0 Td (1,0*)Tj /T1_1 1 Tf 7 0 0 7 70.8661 506.3982 Tm (\004\032\022\026\027\007\020\025\022\027: \215\027)Tj /Span<>> BDC ( )Tj EMC (\227 \026\027\030\022\020\025\020; Q1, Q3)Tj /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023)0.7(\027\024\023 \215\020\025\025\020\231\210)50(\022\023\025\022; ***)]TJ /Span<>> BDC ( )Tj EMC (\227 \250)Tj 4.081 0 0 4.081 409.3591 508.7292 Tm (2)Tj 7 0 0 7 411.3996 506.3982 Tm ( \004\022\032\024\031\025\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7527 56.0378 Tm (130)Tj ET endstream endobj 749 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.179 Tw 10 0 0 10 42.5197 310.7779 Tm (\030\036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (54 \(98,2%\) \002\024\035\034\027\t\b, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016 \022\026\022 )Tj 0.303 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (24 \(77,4%\) )Tj 0.138 Tw T* (\023\026\006\017\036\027\021\024\r \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.138 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,003\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\031\004\036\027\017\017 \f\022\024\030\024\f\021\017 \r\024\f)Tj 0 Tw (-)Tj 0.261 Tw T* (\f\021\026\027\024\r\035\036\027\017\016 \n\024\021\024\030\027\024\005 \ \235\031\027\022\006\017\017 \032\036\035\031\007\024\004\027\024-\022\017\ \001\036\004)Tj 0 Tw (-)Tj 0.356 Tw T* [(\027\024\020\024 )0.5(\021\030\026\022\021\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.769 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036, )0.6(\002\t\035\024 )]TJ 0.223 Tw -6.769 -1.218 Td (\024\021\n\036\004\036\027\024, \004\021\024 \r\030\036\n\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\024\020\024 \024\021\b\024\032\007\036\027\017\016 \020\026\ \024\r )Tj 0.138 Tw T* (\027\036 \030\026\035\017\004\026\035\024\f\034, \n\036\007\017\026\027\ \026 \220\021\024\020\024 \023\024\022\026\026\021\036\035\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.109 Tw T* (\f\036\020\n\036\027\021\026\030\027\024\005 \f\024\f\021\026\r\017\035\026\ 2 \(1; 3\) \f\031\021\024\022 \017)Tj /Span<>> BDC ( )Tj EMC (2 \(2; 3\))Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.153 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.859 0 Td [(\020\030\031\023\023\036 )0.6(\030\026\f\001\017\030\036\027\027\024\005 )0.5(\030\036\036\022\006\017\017 )0.6(\()]TJ /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.153 Tw /Span<>> BDC ( )Tj EMC 14.643 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.885 0 Td [(0,42\). )0.5(\210\007\027\026\022\024 )]TJ 0.034 Tw -16.388 -1.218 Td (\031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \020\030\031\023\023\t \030\026\f\001\ \017\030\036\027\027\024\005 \030\036\036\022\006\017\017 \002\t\035\024\ \026)Tj 0 Tw (-)Tj 0.236 Tw T* (\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \002\024\035\036\036\ \030\026\027\027\036\036 \024\021\b\024\032\007\036\027\017\036 \023\036\ \030\r\024\020\024 )Tj 0.001 Tw T* (\f\021\031\035\026)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \(2; 4\) \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024 \r\030\036\n\016, )Tj 0.142 Tw T* (\022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\ \036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \027\026)Tj /Span<>> BDC ( )Tj EMC (4 \(3; 5\) )Tj 0.101 Tw T* (\f\031\021\022\017 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.101 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\). \222\030\024\022\017 \023\030\036\002\t\r\026\027\017\016 \023\024\ \f\035\036 \024\023\036\030\026\006\017\017 )Tj 0.092 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\006\017\024\027\026\030\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 )0.5(\f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022\006\017\017\ )0.5(\002\t\035\017 )]TJ 0.143 Tw T* (\022\024\030\024\004\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027 \007\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 8 \(6; 10\) \023\030\024\021\017\r 9 \(7; 11\), )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.576 Tw T* (\210\f\035\024\032\027\036\027\017\016 \030\026\r\017\035\017\f\034 \031\ )Tj /Span<>> BDC ( )Tj EMC (11/55 \(20%\) \023\026\006\017\036\027)Tj 0 Tw (-)Tj 0.163 Tw T* [(\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.619 0 Td [(\020\030\031\023\023\036 )0.5(\222\217 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.468 0 Td [(\031 )0.5(13/31 )0.5(\(41,9%\))]TJ /Span<>> BDC ( )Tj EMC 7.258 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.265 0 Td [(\020\030\031\023\023\036 )0.5(\217\217. )]TJ 0.3 Tw -17.611 -1.218 Td (\215\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\036 \017)Tj /Span<>> BDC ( )Tj EMC (\021\016\032\036\f\021\017 \030\026\r\017\r\001\017\b\f\016 \024\f\035\024\ \032\027\036\027\017\005 )Tj 0.309 Tw 23.244 23.138 Td (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\ \026\035\017\004\017\005 \n\036\032\007\031 \022\024\020\024\030\021\026\ )Tj 0 Tw (-)Tj 0.097 Tw T* (\n\017 \024\002\027\026\030\031\032\036\027\024 \027\036 \002\t\035\024.\ \200)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \023\030\017\n\036\030\027\ \024 )Tj -0.03 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\024\005 \004\026\f\021\024\021\024\005 \017\n\036\035\017\ \n\036\f\021\024 \024\f\035\024\032\027\036\027\017\016 I \017)Tj /Span<>> BDC ( )Tj EMC (II)Tj /Span<>> BDC ( )Tj EMC (\f\021\036)Tj 0 Tw (-)Tj 0.335 Tw T* [(\023\036\027\017 \(\023\024 \001\022\026\035\036 Cl)-16(av)-16(ien\226Dind)-15.9(o [10]\). \210\f\035\024\032\027\036\027\017\016 )]TJ -0.036 Tw T* (III)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017, \023\024\021\030\036\002\024\r\026\r\001\017\ \036 \023\024\r\021\024\030\027\t\b \r\n\036\001\026\021\036\035\034\f\021\ \r, )Tj 0.065 Tw T* (\030\026\r\017\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (2 \(3,6%\) \023\026\006\017\036\027\021\024\r \023\024\f\035\036 \f\036\020\ \n\036\027\021\026\030\027\t\b )Tj 0.09 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031 4 \(12,9%\))Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\f\035\036 \030\026\f\001\017\030\036\027\027\t\b \024\023\036\ \030\026\006\017\005. \210\027\017 )Tj 0.691 Tw T* (\002\t\035\017 \023\030\036\007\f\021\026\r\035\036\027\t \027\036\f\024\ \f\021\024\016\021\036\035\034\027\024\f\021\034\033 \n\036\032\022\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026 \031)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8%\) \023\026\006\017\036\027\021\026 \020\030\031\023\023\t \222\217\ )Tj -0.029 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023\023\t \217\217, \023\036\030\235\024\030\026\006\017\ \036\005 \021\024\027\022\024\005 \022\017\001)Tj 0 Tw (-)Tj 0.007 Tw T* (\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2%\) \027\026\002\035\033\007\036\027\017\017 \023\024\f\035\036 \030\ \026\f\001\017\030\036\027\027\024\005 \030\036\036\022)Tj 0 Tw (-)Tj -0.049 Tw T* [(\006\017\017 \024\002\024\007\024\004\027\024\005 )0.5(\022\017\001\022\017, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 10.054 0 Td (\021\026\022\032\036 \027\036\005\030\024\020\036\027\027\024\005 \007\017\ \f\235\031\027\022)Tj 0 Tw (-)Tj 0.293 Tw -10.054 -1.218 Td [(\006\017\036\005 \n\024\004\036\r\024\020\024 \023\031\t\030\016, )0.5(\023\024\021\030\036\002\024\r\026\r\001\036\005 \027\026\035\024\032\036\ \027\017\016 )]TJ -0.015 Tw T* (\220\023\017\006\017\f\021\024\f\021\024\n\t \r)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8%\) \f\035\031\004\026\036 \023\024\f\035\036 \f\036\020\n\036\027\021\ \026\030\027\024\005 )Tj -0.006 Tw T* (\030\036\036\022\006\017\017 \023\024\023\036\030\036\004\027\024\005 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017. \210\007\027\024 \ \(3,2%\) )Tj 0.119 Tw T* (\024\f\035\024\032\027\036\027\017\036 IV \f\021\036\023\036\027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \217\217 \002\t\035\024 \023\030\036\007\f\021\026\ \r)Tj 0 Tw (-)Tj 0.057 Tw T* (\035\036\027\024 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \034\033 \n\036\032\022\017\001\036\004\027\024\020\024 \026\027\026\f\021\ \024\n\024\026 )Tj 0.286 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\r\017\r\001\017\n\f\016 \r\023\024\f\035\036\007\f\021\r\017\017\ )0.5(\026\002\007\024\n\017\027\026\035\034\027\t\n \f\036\023)]TJ 0 Tw (-)Tj 0.236 Tw T* (\f\017\f\024\n. \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \035\036\021\026\035\034\027\024\f\021\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \026\030\036\020\017\f\021\030\017\030\024\r\ \026\027\024 \027\036 \002\t\035\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \031\033\027\032\020\ \006\022\235 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\031\b\031 \033\ \027\032\022\031\030\020 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29(i)-1.4(o)-4(n)3.7(s a)-5.1(n)-4.8(d t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(p)-9(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-2.8(v)2.3(e p)-11.3(e)-6(r)-39(i)-1.4(o)-12(d i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 715.181 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 346.0768 715.181 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 241.1949 694.1118 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 346.0768 694.1118 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 450.9586 694.1118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 663.7005 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 663.4505 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 663.4505 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 663.4505 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 663.4505 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 652.2393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 651.9893 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 651.9893 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 651.9893 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 651.9893 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 640.778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 640.528 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 241.1949 640.528 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 346.0768 640.528 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 450.9586 640.528 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 610.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 609.8667 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 609.8667 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 609.8667 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 609.8667 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 598.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 598.4054 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 598.4054 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 598.4054 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 598.4054 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 587.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 586.9441 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 586.9441 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 586.9441 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 586.9441 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 575.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 575.4828 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 241.1949 575.4828 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 575.4828 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 450.9586 575.4828 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 122.3426 701.7465 Tm (\200\004\006\004\214\r\003\006\013)Tj 16.254 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.326 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 9.838 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 10.962 0.6 Td (p)Tj /T1_1 1 Tf -53.244 -2.033 Td (\200\017\007 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \007\024\ \f\021\031\023\026)Tj 1.063 -1.2 Td (\214\026\023\026\030\024\f\022\024\023\017\004\036\f\022\017\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj -0 -1.2 Td (\210\021\022\030\t\021\t\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 28.112 1.2 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(69,1\))Tj T* (17)Tj /Span<>> BDC ( )Tj EMC (\(30,9\))Tj 13.11 1.2 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(67,7\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(32,3\))Tj 10.126 2.4 Td (1,0*)Tj -52.661 -3.833 Td (\025\030\024\r\024\023\024\021\036\030\016, \n\035 \204\036 \(Q1; Q3\))Tj 28.403 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(26,2; 50\))Tj 13.203 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(50; 100\))Tj 10.306 0 Td (0,02***)Tj -51.911 -1.433 Td (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017, \n\017\027 \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD\))Tj 28.586 0 Td (196,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (57,1)Tj 13.11 0 Td (192,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (60,2)Tj 10.465 0 Td (0,73**)Tj -52.161 -1.433 Td (\200\017\007 \026\027\026\f\021\024\n\024\026)Tj 1.063 -1.2 Td (\217\031\004\027\024\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj -0 -1.2 Td (\202\023\023\026\030\026\021\027\t\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 28.112 1.2 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(98,2\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 12.61 1.2 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(77,4\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(22,6\))Tj 9.626 2.4 Td (0,003*)Tj -52.161 -3.833 Td (\210\021\b\024\032\007\036\027\017\036 \023\036\030\r\t\b \020\026\024\r\ , \f\031\021\022\017 \204\036 \(Q1; Q3\))Tj 29.495 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1; 3\))Tj 13.11 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(2; 3\))Tj 9.306 0 Td (0,42***)Tj -51.911 -1.433 Td (\210\021\b\024\032\007\036\027\017\036 \023\036\030\r\024\020\024 \f\021\ \031\035\026, \f\031\021\022\017 \204\036 \(Q1; Q3\))Tj 29.495 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(3; 5\))Tj 13.11 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(2; 4\))Tj 9.306 0 Td (0,06***)Tj -51.911 -1.433 Td (\025\024\005\022\024-\007\036\027\034 \023\024\f\035\036 \024\023\036\030\ \026\006\017\017, \204\036 \(Q1; Q3\))Tj 29.245 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(6; 10\))Tj 13.11 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(7; 11\))Tj 9.556 0 Td (0,13***)Tj /T1_2 1 Tf 7 0 0 7 42.5197 563.9982 Tm (\004\032\022\026\027\007\020\025\022\027: \215)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \020\032\022\203\026\027\023\022\007\027\ \024\n\031\027, SD)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\020\025\030\020\032\023\025\031\027 \031\023\n\f\031\025\027\ \025\022\027, \215\027)Tj /Span<>> BDC ( )Tj EMC [(\227 \026\027\030\022\020\025)0.7(\020; Q1, Q3)]TJ /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD (t-\n\032\022\023\027\032\022\235 \205\023\017\005\030\027\025\023\020; *\ **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\027\024\023 \215\020\025\025\020\231\210)50.3(\022\023\025\022.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 536.2943 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \232\020\024\023\031\023\020 \022)Tj /Span<>> BDC ( )Tj EMC (\024\023\032\r\n\023\r\032\020 \033\031\024\f\027\031\033\027\032\020\006\ \022\031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235 \033\031\ )Tj /Span<>> BDC ( )Tj EMC 29.3 0 Td (\213\n\020\f\027 Clavien-Dindo \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw -29.3 -1.2 Td [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.318 0 Td [( F)29.2(r)-2(e)-9.4(q)-3(u)-3.2(e)-6.9(n)-2.9(c)-32.4(y a)-5.1(n)-4.8(d s)-14.8(t)-9.6(r)-9(u)-3.7(c)-32.4(t)-1.1(u)1.6(r)-2(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-9(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.2(t)-29.1(i)-2.9(v)2.3(e c)2.9(o)-4(m)-1(p)-4.9(li)-1.8(c)3.3(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-9.2(c)2.3(c)2.8(o)-3(r)-2.9(d)-3(i)3.9(n)-0.6(g t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e C)1.2(l)-1.1(a)-8.7(v)-32.5(i)-1.4(e)-7(n)-13.4(-)-14.3(D)-12.1(i)3.9(n)-4.8(d)-5.2(o sc)3.2(a)-4.5(le i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 520.9923 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 520.9923 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 346.0768 520.9923 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9587 520.9923 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 500.1731 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 499.9231 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 241.1949 499.9231 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 346.0768 499.9231 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 450.9587 499.9231 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 469.5118 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 469.2618 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 241.1949 469.2618 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 346.0768 469.2618 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 450.9587 469.2618 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 496.313 419.6505 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 42.5197 419.4005 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 241.1949 419.4005 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 346.0768 419.4005 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 450.9587 419.4005 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 496.313 379.3892 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 42.5197 379.1392 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 379.1392 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 379.1392 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 379.1392 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 367.928 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 367.678 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 367.678 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 367.678 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 367.678 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 356.4667 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 356.2167 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 241.1949 356.2167 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 241.1949 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 346.0768 356.2167 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 356.2167 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 345.0054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 344.7554 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 241.1949 344.7554 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 346.0768 344.7554 cm 0 0 m 104.882 0 l S Q q 1 0 0 1 450.9587 344.7554 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 83.1589 507.5577 Tm (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\013\r \002\217\f\002\202\ \b\r\b\t\235)Tj 21.152 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.326 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 9.838 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 10.962 0.6 Td (p)Tj /T1_1 1 Tf -53.244 -2.033 Td (I \f\021\036\023\036\027\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\214\017\b\024\030\026\007\022\026)Tj 0 -1.2 TD (\206\036\n\026\021\024\n\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\005 \030\026\027\t)Tj 28.612 2.4 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,4\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(3,6\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 13.11 2.4 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj 9.876 2.4 Td (1,0*)Tj T* (1,0*)Tj T* (1,0*)Tj -52.661 -1.433 Td (II \f\021\036\023\036\027\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\210\f\021\030\t\005 \023\026\027\022\030\036\026\021\017\021)Tj T* (\215\026\030\036 \240\025\221)Tj T* (\025\035\024\f\021\030\017\007\017\026\035\034\027\t\005 \022\024\035\017\ \021)Tj T* (\233\r\036\027\021\030\026\006\017\016)Tj 28.362 4.8 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10,9\))Tj 1.329 -1.2 Td (0)Tj -1.079 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,4\))Tj 1.079 -1.2 Td (0)Tj -1.079 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 12.86 4.8 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(19,3\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(6,4\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(3,4\))Tj 1.079 -1.2 Td (0)Tj 8.547 4.8 Td (0,34*)Tj T* (0,36*)Tj 0.25 -1.2 Td (1,0*)Tj T* (1,0*)Tj T* (1,0*)Tj -52.661 -1.433 Td (III \f\021\036\023\036\027\034, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \026\027\026\ \f\021\024\n\024\026)Tj T* (\215\036\030\235\024\030\026\006\017\016 \021\024\027\022\024\005 \022\017\ \001\022\017)Tj T* (\203\036\005\030\024\020\036\027\027\026\016 \007\017\f\235\031\027\022\006\ \017\016 \n\024\004\036\r\024\020\024 \023\031\t\030\016)Tj 28.612 3.6 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,6\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 1.079 -1.2 Td (0)Tj -1.079 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1,8\))Tj 12.86 3.6 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(12,9\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(10,7\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj 1.079 -1.2 Td (0)Tj 8.547 3.6 Td (0,18*)Tj T* (0,11*)Tj T* (0,36*)Tj 0.25 -1.2 Td (1,0*)Tj -52.661 -1.433 Td (IV \f\021\036\023\036\027\034 \(\222\036\023\f\017\f\), )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 30.754 0 Td (0)Tj 12.031 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj 9.626 0 Td (0,36*)Tj -52.411 -1.433 Td (V \f\021\036\023\036\027\034)Tj 30.754 0 Td (0)Tj 13.11 0 Td (0)Tj 9.362 0 Td (\226)Tj -53.226 -1.433 Td (\232\026\f\021\024\021\026 \024\f\035\024\032\027\036\027\017\005, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 29.175 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(20,0\))Tj 13.11 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(41,9\))Tj 10.126 0 Td (0,04*)Tj /T1_2 1 Tf 7 0 0 7 42.5197 333.2707 Tm (\004\032\022\026\027\007\020\025\022\027: *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (129)Tj ET endstream endobj 747 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.165 Tw 10 0 0 10 70.8661 542.1599 Tm (\023\030\026\r\007\024\023\024\007\024\002\017\016 \(LR)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (10\), \021\036\f\021\026 \216\024\f\n\036\030\026\226\214\036\n\036\001\024\ \r\026 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf -0.028 Tw /Span<>> BDC ( )Tj EMC 1.052 0 Td (>)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(0,05\), )0.5(R)]TJ 0 Tw 5.83 0 0 5.83 118.151 533.3119 Tm (2)Tj -0.028 Tw 10 0 0 10 121.066 529.9819 Tm [( )0.5(\204\026\022\235\026\007\007\036\027\026. )0.6(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\027\026\004\017\n\024\f\021\034 )]TJ 0.044 Tw -5.02 -1.218 Td (\023\030\017\027\017\n\026\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \210\002\030\026\002\024\021\022\026 \007\026\027\027\t\b \r\t\023\ \024\035)Tj 0 Tw (-)Tj T* (\027\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC [(G)20.1(r)-33(aphP)40(adP)35(r)-37(is)26(m v.10 \(\222\231\202\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 469.0919 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.372 Tw 10 0 0 10 70.8661 444.7359 Tm [(\206\030\031\023\023\t )0.5(\002\t\035\017 )0.6(\f\024\023\024\f\021\026\r\017\n\t)]TJ /Span<>> BDC ( )Tj EMC 12.325 0 Td [(\227 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 3.21 0 Td [(\023\024\035\031, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 3.789 0 Td (\020\030\031\023\023\036 )Tj 0.202 Tw -19.324 -1.218 Td (\222\217 \n\031\032\004\017\027 \002\t\035\024 23)Tj /Span<>> BDC ( )Tj EMC (\(41,8%\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \217\217)Tj /Span<>> BDC ( )Tj EMC (\227 10)Tj /Span<>> BDC ( )Tj EMC (\(32,3%\) )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.08 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,36\). \221\026\022\032\036 \027\036 \024\021\n\036\004\036\027\024 \030\ \026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\036\007\036)Tj 0 Tw (-)Tj 0.084 Tw T* (\035\036\027\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\031: \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \222\217 \f\030\036\007\027\017\005 \r\024\030\ \026\f\021 \f\024)Tj 0 Tw (-)Tj 0.04 Tw T* (\f\021\026\r\017\035 65,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (11,7 \035\036\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \217\217)Tj /Span<>> BDC ( )Tj EMC (\227 69,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,9 \035\036\021 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.046 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07\). \230\027\007\036\022\f \n\026\f\f\t \021\036\035\026 \(\230\204\221\ \) \002\t\035 \f\024\023\024\f\021\026\r\017\n )Tj 0.234 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\235\024\030\n\017\030\024\r\026\027\027\t\b \r\t\002\024\030\022\026\b\ , \036\020\024 \n\036\007\017\026\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023)Tj 0 Tw (-)Tj 0.443 Tw T* (\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\036\036\022\006\ \017\017 \f\024\f\021\026\r\017\035\026 28,1 \(25,1; )Tj 0.273 Tw T* (30,6\) \022\020/\n)Tj 0 Tw 5.83 0 0 5.83 114.9287 350.6418 Tm (2)Tj 0.273 Tw 10 0 0 10 117.8437 347.3119 Tm (, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\024\005 \030\ \036\036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.296 Tw -4.698 -1.218 Td (26,0 \(23,9; 27,7\) \022\020/\n)Tj 0 Tw 5.83 0 0 5.83 166.2453 338.4639 Tm (2)Tj 0.296 Tw 10 0 0 10 169.1603 335.1339 Tm (, \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.296 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,13\). \217\026\f\023\030\036\007\036\035\036\027\017\036 )Tj 0.179 Tw 13.415 20.703 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\026\n \026\027\036\f\021\036\017\024\035\024\020\017\004\ \036\f\022\024\020\024 \030\017\f\022\026 A)35(SA \(I-III\) )]TJ T* (\021\026\022\032\036 \027\036 \030\026\035\017\004\026\035\024\f\034 \(\ )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.179 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,58\). \210\007\027\026\022\024 \023\026\006\017\036\027\021\t )Tj -0.006 Tw T* (\020\030\031\023\023\t \217\217 \017\n\036\035\017 \002\024\035\036\036 \ \r\t\f\024\022\017\005 \017\027\007\036\022\f \022\024\n\024\030\002\017\ \007\027\024)Tj 0 Tw (-)Tj -0.002 Tw T* (\f\021\017 \232\026\030\035\f\024\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 8,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,4 \002\026\035\035\024\r \023\030\024\021\017\r 6,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,7)Tj /Span<>> BDC ( )Tj EMC (\002\026\035)Tj 0 Tw (-)Tj T* (\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \222\217 \()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.247 Tw T* (\215\030\017 \r\t\023\024\035\027\036\027\017\017 \024\023\036\030\026\006\ \017\005 \023\030\036\024\002\035\026\007\026\035 \035\026\023\026\030\024\ \f\022\024)Tj 0 Tw (-)Tj 0.007 Tw T* (\023\017\004\036\f\022\017\005 \007\024\f\021\031\023, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\ \036\036\022\006\017\017 \024\027 )Tj 0.037 Tw T* (\002\t\035 \023\030\017\n\036\027\036\027 \031)Tj /Span<>> BDC ( )Tj EMC (38/55 \(69,1%\) \023\026\006\017\036\027\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 )Tj 0.062 Tw T* (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (21/31 \(67,7%\) \002\024\035\034\027\024\020\024 )Tj 0 Tw T* (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.05 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\). \212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\ \006\017\005 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026)Tj 0 Tw (-)Tj 0.18 Tw T* (\004\017\n\024 \027\036 \030\026\035\017\004\026\035\026\f\034 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 196,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (57,1)Tj /Span<>> BDC ( )Tj EMC (\n\017\027 )Tj 0.242 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.949 0 Td [(\020\030\031\023\023\036 )0.5(\222\217 )0.5(\023\030\024\021\017\r )0.5(192,3)]TJ /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC 11.697 0 Td [(60,2 )0.5(\n\017\027 \r)]TJ /Span<>> BDC ( )Tj EMC 5.183 0 Td [(\020\030\031\023\023\036 )0.5(\217\217 )]TJ 0 Tw -17.828 -1.218 Td (\()Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf 0.251 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,73\). \204\036\007\017\026\027\026 \022\030\024\r\024\023\024\021\036\030\ \017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b )Tj -0.017 Tw T* (\002\t\035\026 \n\017\027\017\n\026\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 50 \n\035. \217\026\035\017\004\017\016 \ \r)Tj /Span<>> BDC ( )Tj EMC (\n\036)Tj 0 Tw (-)Tj 0.001 Tw T* [(\007\017\026\027\027\t\b )0.6(\027\026\004\036\027\017\016\b )0.6(\024\002\255\036\n\026 )0.5(\022\030\024\r\024\023\024\021\036\030\017 )0.5(\n\036\032\007\031 )0.6(\020\030\031\023)]TJ 0 Tw (-)Tj 0.11 Tw T* (\023\026\n\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n \002\t\035\017 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 \()]TJ /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.11 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,02\), \027\024 )0.5(\027\036 )]TJ 0.107 Tw T* [(\022\035\017\027\017\004\036\f\022\017 \027\026\004\017\n\t. )0.5(\204\036\032\022\017\001\036\004\027\t\005 \026\027\026\f\021\024\n\024\ \030\031\004)]TJ 0 Tw (-)Tj 0.062 Tw T* (\027\t\n \f\023\024\f\024\002\024\n \004\026\013\036 \235\024\030\n\017\030\ \024\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\036\020\n\036\027\021\026\030\027\024\005 )Tj ET q 70.866 100.97 345.827 215.937 re W n q /GS0 gs 345.8267624 0 0 215.9917297 70.8661499 100.9151917 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \221\f\031\n-\024\200\027\026\020 \022\024\024\f\027\030\031\021\020\025\ \022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(esearch scheme)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \b\032\r\033\033 \033\ \020\006\022\027\025\023\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 3.324 0 Td [( C)0.9(h)2.4(a)-2.2(r)5.3(a)-7.2(c)-30.3(te)-4(r)-37(i)8.6(s)-12.8(t)-27.1(ic)-24.7(s)2( o)6.1(f)]TJ /Span<>> BDC 7.087 0 Td ( )Tj EMC [(p)-4.3(a)-7.2(t)-27.1(i)0.7(e)-5.1(n)1.5(t)2( g)0.5(ro)-1.4(up)3.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 252.5335 715.181 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 360.25 715.181 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 467.9666 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 252.5335 694.1118 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 360.25 694.1118 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 467.9666 694.1118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 524.6594 663.7004 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 663.4504 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 663.4504 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 663.4504 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 663.4504 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 652.2392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 651.9892 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 651.9892 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 651.9892 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 651.9892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 640.7779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 640.5279 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 252.5335 640.5279 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 360.25 640.5279 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 467.9666 640.5279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 524.6594 600.5166 cm 0 0 m 0 39.761 l S Q q 1 0 0 1 70.8661 600.2666 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 71.1161 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 252.5335 600.2666 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 252.5335 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 600.2666 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9666 600.2666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9666 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 589.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 588.8054 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 252.5335 588.8054 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 360.25 588.8054 cm 0 0 m 107.717 0 l S Q q 1 0 0 1 467.9666 588.8054 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 142.1851 701.7464 Tm (\200\004\006\004\214\r\003\006\013)Tj 15.368 0.6 Td (\255\r\n\214\r\b\003\004\006\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.326 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\))Tj 10.193 1.2 Td (\022\004\217\230\t\006\r\b\b\004\235 \006\r\213\r\220\204\t\235 )Tj 3.272 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\))Tj /T1_4 1 Tf 11.848 0.6 Td (p)Tj /T1_0 1 Tf -52.536 -2.033 Td (\215\024\035, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\204\031\032\f\022\024\005)Tj T* (\240\036\027\f\022\017\005)Tj 26.163 1.2 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(41,8\))Tj T* (32)Tj /Span<>> BDC ( )Tj EMC (\(58,2\))Tj 13.465 1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(32,3\))Tj T* (21)Tj /Span<>> BDC ( )Tj EMC (\(67,7\))Tj 11.012 2.4 Td (0,49*)Tj -51.703 -3.833 Td (\200\024\030\026\f\021, \035\036\021 \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD\))Tj 27.23 0 Td (65)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (11,7)Tj 13.372 0 Td (69,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (9,9)Tj 10.851 0 Td (0,07**)Tj -51.453 -1.433 Td (\230\027\007\036\022\f \n\026\f\f\t \021\036\035\026, \022\020/\n\262 \204\ \036 \(Q1; Q3\))Tj 25.769 0 Td (28,1)Tj /Span<>> BDC ( )Tj EMC (\(25,1; 30,6\))Tj 13.807 0 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(23,9; 27,7\))Tj 11.627 0 Td (0,13***)Tj -51.203 -1.433 Td (\025\035\026\f\f \023\024 \001\022\026\035\036 ASA, )Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf ( \(%\))Tj 1.063 -1.2 Td (ASA I)Tj 0 -1.2 TD (ASA II)Tj 0 -1.2 TD (ASA III)Tj 26.663 2.4 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9,1\))Tj -0.5 -1.2 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(47,3\))Tj T* (24)Tj /Span<>> BDC ( )Tj EMC (\(43,6\))Tj 13.965 2.4 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3,2\))Tj -0.5 -1.2 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(48,4\))Tj T* (15)Tj /Span<>> BDC ( )Tj EMC (\(48,4\))Tj 10.262 3.6 Td (0,58****)Tj -50.953 -5.033 Td (\230\027\007\036\022\f \022\024\n\024\030\002\017\007\027\024\f\021\017 \ \232\026\030\035\f\024\027\026 \(M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD\))Tj 27.387 0 Td (6,9)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,7)Tj 13.465 0 Td (8,1)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (2,4)Tj 10.601 0 Td (0,03**)Tj /T1_1 1 Tf 7 0 0 7 70.8661 577.3207 Tm (\004\032\022\026\027\007\020\025\022\027: \215)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\027\027 \020\032\022\203\026\027\023\022\007\027\ \024\n\031\027, SD)Tj /Span<>> BDC ( )Tj EMC (\227 \024\023\020\025\030\020\032\023\025\031\027 \031\023\n\f\031\025\027\ \025\022\027, \215\027)Tj /Span<>> BDC ( )Tj EMC [(\227 \026\027\030\022\020\025)0.7(\020; Q1, Q3)]TJ /Span<>> BDC ( )Tj EMC (\227 25% \022)Tj /Span<>> BDC ( )Tj EMC (75% \n\021\020\032\023\022\f\022; *)Tj /Span<>> BDC ( )Tj EMC (\227 \023\027\024\023 \214\022\213\027\032\020; **)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD (t-\n\032\022\023\027\032\022\235 \205\023\017\005\030\027\025\023\020; *\ **)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\027\024\023 \215\020\025\025\020\231\210)50.3(\022\023\025\022; ****)]TJ /Span<>> BDC ( )Tj EMC (\227 \250)Tj 4.081 0 0 4.081 253.8083 571.2516 Tm (2)Tj 7 0 0 7 255.8488 568.9207 Tm ( \004\022\032\024\031\025\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 20.7902 56.0378 Tm (128)Tj ET endstream endobj 748 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;Z   V#!1"AQRUa2ST#Bq$34b %&'()*56789:CDEFGHIJVWXYZcdefghijrstuvwxyz?QеQcp!1P8`pL>F=ϐtms+{GNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O991{{i<QGNL`^O9kԫaEf6nvZB9ܭov!N.,q+{ÚZátݭZ'b!p|Y6KL6jVy-llHQ>N-xiWOńqB[S״ev:#c%j\K3VϧZ, Y9͉f@.!mǵ$N*fV =I3˴HIu݇9>ڊ= ۗbK%x7z?4DGK>` o! wv+F_ 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RZ;5h$oksO dݯJN>!ݯJN>!ݯJN>!ݯJZ0x5Cf'F8f8!DMOzKH,JT8hyr ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJN>!ݯJ\%7 {L"dԱuK#X\I9M$EZ@M.S̴G9YfˆmtGeXf;^ #: c q B ndySC3c5k1[A TfHɔO夞nnt {gYA4#4Qhm} C8+J59 GG 9F[4Ay:Hi+uW>; 5F4:\.p >嚍I%u1#nlb&[ ioGRwܒ[*5eh49獡Iic v>DU23!e+z1AȭVyQ$Nuwds7̘xlXdv0ޮ fEpk^ִFsA O y^颚S;ۘldc^pA bfs,}{08#%x07>+*٪l e$֦Yk|Fhef9;0ANnoWIۊ>e+0N4vLˏ9-T- b^,] h7ś`fb !&ؘpXG\'HrhcF9oz6֗O"\r Ï3chdut (z{'(z{'(z{'(z{'(z{'(z{/cfn[(#?C Ef$`n̴ὡe:{ U؞+q'Ǽu+;,#%mr7r7r7r7r7r7r7r7r7r7r7Ç!vB0k f, oXx8s)DDDDDDDDDDDDDDDDDDDDDֵQ׵Q endstream endobj 751 0 obj <>stream endstream endobj 746 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.017 Tw 10 0 0 10 42.5197 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\f\035\036\007\027\017\036 \024\002\036\f\023\036\004\017\r\ \026\033\021 \031\007\026\035\036\027\017\036 \002\024\035\034)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD (\001\036\020\024 \022\024\035\017\004\036\f\021\r\026 \035\017\n\235\026\ \021\017\004\036\f\022\017\b \031\035\024\r \017, \021\036\024\030\036\021\ \017\004\036)Tj 0 Tw (-)Tj 0.188 Tw T* (\f\022\017, \n\024\020\031\021 \002\t\021\034 \f\r\016\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\n \030\026\007\017\022\026\035\017\n\024\n. )Tj 0.06 Tw T* (\203\024, \027\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024, )0.5(\004\026\f\021\024\021\026 \023\024\030\026\032\036\027\017\016 )0.5(\035\017\n\235\024\031\035\024\r )]TJ 0.123 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \024\002\024\017\b \021\017\023\024\ \r \r\n\036\001\026\021\036\035\034\f\021\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027)Tj 0 Tw (-)Tj 0.127 Tw T* (\027\t\n Guan X. \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\ \004\017\n\024 \027\036 \030\026\035\017\004\026\035\026\f\034 )Tj 0.083 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\017\035\026 34% \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.083 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,985\) [6]. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 )Tj 0.104 Tw 0 -1.218 TD (\024\023\031\002\035\017\022\024\r\026\027\t \030\026\002\024\021\t, \f\030\ \026\r\027\017\r\026\033\013\017\036 \f\036\020\n\036\027\021\026\030\027\ \031\033 )Tj 0.279 Tw T* (\030\036\036\022\006\017\033 \023\024\023\036\030\036\004\027\024\005 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017)Tj 0 Tw (-)Tj 0.389 Tw T* (\030\036\027\027\031\033 \023\030\026\r\024\f\021\024\030\024\027\027\033\ \033 \020\036\n\017\022\024\035\220\022\021\024\n\017\033, \017\b \030\036\ )Tj 0 Tw (-)Tj 0.05 Tw T* [(\031\035\034\021\026\021\t \023\030\024\021\017\r\024\030\036\004\017\r\ \t. Mil)30.1(one e)-12(t al. \(2020\) \023\030\024\007\036)]TJ 0 Tw (-)Tj 0.07 Tw T* (\n\024\027\f\021\030\017\030\024\r\026\035 \023\030\036\017\n\031\013\036\ \f\021\r\026 \030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\ \006\017\017 )Tj 0.093 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC [(\024\021\027\024\001\036\027\017\017 \f\027\017\032\036\027\017\016 )0.5(\004\026\f\021\024\021\t \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\b )]TJ -0.022 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005 \f)Tj /Span<>> BDC ( )Tj EMC (30,1% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\t\b \030\036\ \036\022\006\017\005 )Tj 0.042 Tw 0 -1.218 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (23,6% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f\001\017\030\036\027\027\t\b \030\036\ \036\022\006\017\005 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.042 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,01\). )Tj 0.55 Tw T* (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \026\027\026\ \f\021\024\n\024\026 \004\026\013\036 \030\026\r\017\r\026\035\026\f\034\ )Tj 0.167 Tw T* (\023\024\f\035\036 \f\036\020\n\036\027\021\026\030\027\024\005 \030\036\ \036\022\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 4,4% \023\030\024\021\017\r 2,2% )Tj 0.063 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \217\217 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.063 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\). \221\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\036\020\n\036\027\021\026\030\027\024\005 )Tj 0.53 Tw T* [(\030\036\036\022\006\017\017 )0.5(3-\035\036\021\027\016\016 )0.5(\002\036\030\036\006\017\007\017\r\027\026\016 )0.5(\r\t\032\017\r\026\036\n\024\f\021\034 )]TJ 0.282 Tw T* (\002\t\035\026 \027\017\032\036)Tj /Span<>> BDC ( )Tj EMC (\227 78,1% \023\030\024\021\017\r 86,2% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \030\026\f)Tj 0 Tw (-)Tj 0.21 Tw T* (\001\017\030\036\027\027\t\b \024\023\036\030\026\006\017\005 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.21 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001\) [7]. \200\n\036\f\021\036 \f)Tj /Span<>> BDC ( )Tj EMC (\021\036\n, )Tj 0.26 Tw T* [(M)-24(or)-33(ar)-32.9(asu)]TJ /Span<>> BDC ( )Tj EMC (S. \(2021\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\n \n\036\021\026\026\027\026\035\017\036 \027\036 \024\002\ \027\026)Tj 0 Tw (-)Tj 0.214 Tw T* [(\030\031\032\017\035 )0.5(\027\026\004\017\n\t\b )0.6(\030\026\035\017\004\017\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.769 0 Td [(\r\036\030\024\016\021\027\024\f\021\017 )0.6(\030\026\r\017\021\017\016 )]TJ 0.176 Tw -12.769 -1.218 Td [(\030\036\006\017\007\017\r\026 )0.5(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 6.504 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td [(0,88; )0.5(95% )0.6(\212\230 )0.5(0,59\2261,34; )]TJ /T1_2 1 Tf 0 Tw 10.848 0 Td (\032)Tj /T1_1 1 Tf 0.176 Tw /Span<>> BDC ( )Tj EMC 0.886 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.908 0 Td (0,56\) )Tj 0.172 Tw -20.055 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \024\002\013\036\005 \r\t\032\017\ \r\026\036\n\024\f\021\017 \n\036\032\007\031 \020\030\031\023\023\026)Tj 0 Tw (-)Tj 0.027 Tw T* (\n\017 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,98; 95% \212\230 0,68\2261,4; )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.027 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,9\) [8]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 )Tj 0.08 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \027\026\n\017 \002\t\035\024 \023\030\024\r\036\007\036\027\ \024 \f\030\026\r\027\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r )Tj 0.37 Tw T* (\f\036\020\n\036\027\021\026\030\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0 Tw T* (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 347.3118 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.082 Tw 10 0 0 10 42.5197 322.9558 Tm [(\222\030\026\r\027\017\021\034 \027\036\023\024\f\030\036\007\f\021\r\036\ \027\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \030\036\031\035\034\021\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\021\t \f\036\020\n\036\027\021\026\030\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\b \030\036\036\022\006\017\005 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0 Tw T* (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017\ .)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 262.0658 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.097 Tw 10 0 0 10 42.5197 237.7098 Tm [(\215\030\024\r\036\007\036\027 )0.5(\030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 )0.6(\026\027\026\035\017 )0.6(\002\026\t )0.5(\007\026\027\027\t\b )0.5(\002\024\035\034)]TJ 0 Tw (-)Tj 0.268 Tw T* (\027\t\b, \023\036\030\036\027\036\f\001\017\b \023\035\026\027\024\r\024\ \036 \b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\ \017\036 )Tj 0.167 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \030\026\022\026 \f\030\036\007\027\036\005 \021\030\ \036\021\017 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\ \004)Tj 0 Tw (-)Tj -0.006 Tw T* (\027\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\016 2017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\034 2023 \020\020. )Tj 0.019 Tw T* [(\221\026\022\017\b )0.5(\023\026\006\017\036\027\021\024\r )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 8.313 0 Td [(6 )0.5(\035\036\021 )0.5(\024\022\026\026\035\024\f\034 )0.6(101. )0.5(\025\030\017\021\036\030\017\016\n\017 )]TJ 0.758 Tw -8.313 -1.218 Td (\027\036\r\022\035\033\004\036\027\017\016 \016\r\035\016\035\017\f\034 \ \023\036\030\r\017\004\027\024-\n\027\024\032\036\f\021\r\036\027\027\t\036\ )Tj 0.342 Tw T* (\035\024\022\026\004\036\f\021\r\036\027\027\t\036 \027\024\r\024\024\002\ \030\026\024\r\026\027\017\016 \(\031)Tj /Span<>> BDC ( )Tj EMC (3)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b\), )Tj 0.108 Tw T* (\f\036\n\036\005\027\t\005 \026\007\036\027\024\n\026\021\024 \021\024\035\ \f\021\024\005 \022\017\001\022\017 \(\031)Tj /Span<>> BDC ( )Tj EMC (2 \002\024\035\034\027\t\b\), )Tj 0.164 Tw T* (\r\024\f\023\026\035\017\021\036\035\034\027\t\036 \026\002\024\035\036\ \r\026\027\017\016 \022\017\001\036\004\027\017\022\026 \(\031 2 \002\024\ \035\034)Tj 0 Tw (-)Tj 0.275 Tw T* (\027\t\b\), \024\021\007\026\035\036\027\027\t\036 \n\036\021\026\f\021\026\ \t \(\031)Tj /Span<>> BDC ( )Tj EMC (8)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b\). \200)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.359 Tw T* (\031\035\034\021\026\021\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017 \002\t\035\024 \r\022\035\033\004\036\027\024 86 \023\ \026\006\017\036\027\021\024\r. )Tj 0.224 Tw T* (\214\024\022\026\035\017\026\006\017\016 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 )Tj 0.182 Tw T* (\024\002\024\007\024\004\027\024\005 \022\017\001\022\017 \031\f\021\026\ \027\026\r\035\017\r\026\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\023\026\007\036\027\017\017 )Tj 0.43 Tw T* (\007\026\027\027\t\b \022\024\035\024\027\024\f\022\024\023\017\017, \022\ \024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\235\ \017\017 )Tj -0.001 Tw 23.244 64.543 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \030\ \036\r\017\017\017. \210\002\255\036\n \b\017\030\031\030\020\017\004\036\ \f\022\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\024 \035\036\004\036\027\017\016 \024\023\030\036\007\036\035\016\035\ \f\016 \024\023\036\030\017\030\031\033\013\017\n \b\017\030\031\030\020\ \024\n.)Tj 0.383 Tw 0 -1.218 TD (\207\t\035\026 \023\030\024\r\036\007\036\027\026 \024\006\036\027\022\026\ \f\035\036\007\031\033\013\017\b \007\026\027\027\t\b: \023\024\035, )Tj 0.307 Tw 0 -1.218 TD (\r\024\030\026\f\021, \017\027\007\036\022\f \n\026\f\f\t \021\036\035\026\ , \022\035\026\f\f \026\027\036\f\021\036\017\024\035\024\020\017)Tj 0 Tw (-)Tj 0.097 Tw T* (\004\036\f\022\024\020\024 \030\017\f\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 A)35(SA, \017\027\007\036\022\f \022\024\n\024\030\002\017\007\027\024\f\021\017\ )]TJ 0.037 Tw T* (\232\026\030\035\f\024\027\026, \r\017\007 \b\017\030\031\030\020\017\004\ \036\f\022\024\020\024 \007\024\f\021\031\023\026, \024\002\255\036\n \017\ \027\021\030\026)Tj 0 Tw (-)Tj 0.081 Tw 0 -1.218 TD (\024\023\036\030\026\006\017\024\027\027\024\005 \022\030\024\r\024\023\024\ \021\036\030\017, \007\035\017\021\036\035\034\027\024\f\021\034 \024\023\ \036\030\026\006\017\017, )Tj 0.059 Tw 0 -1.218 TD [(\r\017\007 )0.5(\026\027\026\f\021\024\n\024\026, \r\030\036\n\016 )0.5(\007\024)]TJ /Span<>> BDC ( )Tj EMC [(\023\036\030\r\024\020\024 )0.5(\024\021\b\024\032\007\036\027\017\016 )0.5(\020\026\024\r )]TJ 0.134 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\031\035\026, \004\026\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj -0.023 Tw T* (\035\024\032\027\036\027\017\005, \022\024\035\017\004\036\f\021\r\024 \031\ \007\026\035\036\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\026\032\036\027\027\t\b \035\017\n)Tj 0 Tw (-)Tj 0.153 Tw T* (\235\026\021\017\004\036\f\022\017\b \031\035\024\r, \f\021\026\007\017\ \016 pTNM, \004\026\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030 )Tj 0.401 Tw T* [(\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\016, )0.6(\235\026\022\021 )0.5(\023\030\024\r\036\007\036\027\017\016 )0.6(\026\007\255\033\r\026\027\021\027\024\005 )]TJ 0.029 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (5-\035\036\021\027\016\016 \024\002\013\026\016 \r\t\032\017\r\026\036\n\ \024\f\021\034 \(\210\200\). )Tj -0.017 Tw T* (\221\026\022\032\036 \n\036\021\024\007\024\n \024\023\030\024\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026\035\036\027\027\t\036 \f\030\024\022\017 \017\031\004\026\ \035\026\f\034 )Tj 0.08 Tw T* (\022\030\026\021\027\024\f\021\034 \f\021\031\035\026, \021\017\023 \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\017\f\021\036\027\006\017\016 \022\026\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\207\030\017\f\021\024\035\034\f\022\024\005 \001\022\026\035\024\005 [9\ ].)Tj -0.041 Tw T* (\200 \026\r\017\f\017\n\024\f\021\017 \024\021 \023\030\024\r\036\007\036\ \027\027\024\020\024 \024\023\036\030\026\021\017\r\027\024\020\024 \r\n\ \036\001\026)Tj 0 Tw (-)Tj T* (\021\036\035\034\f\021\r\026 \002\024\035\034\027\t\036 \002\t\035\017 \030\ \026\007\036\035\036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \020\030\031\023\023\t:)Tj 0.199 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \023\026\006\017\036\ \027\021\026\n \r\t\023\024\035\027\016\035\026\f\034 \f\036\020)Tj 0 Tw (-)Tj 0.238 Tw -1.296 -1.218 Td (\n\036\027\021\026\030\027\026\016 \030\036\036\022\006\017\016 \023\024\ \023\036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017 )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf 0.058 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \023\030\024\r\024\007\017\035\024\f\034 \031\ \007\026\035\036\027\017\036 \035\017\n\235\024)Tj 0 Tw (-)Tj 0.18 Tw T* (\031\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\002\026\f\f\036\005\027\036 \f\030\036\007\027\036\005 \024\002\024\007\ \024\004\027\024\005 \026\030\021\036\030\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\036\036 )Tj 0.017 Tw T* (\023\036\030\036\r\016\022\024\005 \031)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\016. \204\024\002\017\035\017\026\006\017\016\ \023\030\026\r\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036)Tj 0 Tw (-)Tj -0.04 Tw T* [(\r\024\020\024 \017\020\017\002\024\r \024\002\024\007\024\004\027\024\005\ )0.5(\022\017\001\022\017 \r\t\023\024\035\027\016\035\026\f\034 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 19.805 0 Td (\031\f\n\024)Tj 0 Tw (-)Tj -19.805 -1.218 Td (\021\030\036\027\017\033 \b\017\030\031\030\020\026.)Tj 0.107 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \023\030\024\017\ \r\024\007\017\035\026\f\034 \030\026\f\001\017\030\036\027\027\026\016\ )Tj 0.234 Tw -1.296 -1.218 Td (\023\030\026\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\ \035\220\022\021\024\n\017\016 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_1 1 Tf 0.234 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\) \f)Tj /Span<>> BDC ( )Tj EMC (\031\007\026\035\036)Tj 0 Tw (-)Tj 0.127 Tw T* (\027\017\036\n \035\017\n\235\024\031\035\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \f\030\036\007\027\017\b \024\002\024\007\024\004\027\t\b\ , \023\024\007)Tj 0 Tw (-)Tj T* (\r\007\024\001\027\024-\024\002\024\007\024\004\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\026\r\t\b \024\002\024\007\024\004\027\t\b \f\024\f\031\007\024\ \r.)Tj /T1_4 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.332 Tw 0 -1.218 TD (\215\030\024\r\036\030\022\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\024\030\n\026\035\034\027\024\036 \030\026\f\023\030\036\007\036\035\ \036\027\017\036 \024\f\031\013\036\f\021)Tj 0 Tw (-)Tj 0.109 Tw T* (\r\035\016\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \022\030\017\021\036\030\017\016 \212\241\202\020\ \024\f\021\017\027\026\226\215\017\030\f\024\027\026. )Tj 0.371 Tw T* (\025\024\035\017\004\036\f\021\r\036\027\027\t\036 \r\036\035\017\004\017\ \027\t \024\023\017\f\t\r\026\035\017\f\034 \f\030\036\007\027\017\n\017\ )Tj -0.022 Tw T* (\027\026\004\036\027\017\016\n\017 \(\204\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\t\n\017 \024\021\022\035\024\027\036\027\ \017\016\n\017 \(\261)Tj /Span<>> BDC ( )Tj EMC (SD\) )Tj 0.484 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \206\026\031\f\f\024\r\026 \030\026\f\023\030\036\ \007\036\035\036\027\017\016, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034)Tj 0 Tw (-)Tj 0.298 Tw T* (\027\t\b \f\035\031\004\026\016\b \007\026\027\027\t\036 \023\030\036\007\ \f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \n\036\007\017\026)Tj 0 Tw (-)Tj 0.255 Tw T* (\027\t \(\204\036\), \027\017\032\027\036\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\036\020\024 \022\r\026\030\021\017\035\036\005 \(Q1; Q3\ \). )Tj 0.05 Tw T* (\222\030\026\r\027\036\027\017\036 \020\030\031\023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\n \r\036\035\017\004\017\027\026\n \024\f\031\013\036\f\021\ \r\035\016\035\024\f\034 )Tj 0.395 Tw T* (t-\022\030\017\021\036\030\017\036\n \222\021\034\033\007\036\027\021\026\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \027\024\030\n\026\035\034\027\024\020\024 )Tj 0.146 Tw T* [(\030\026\f\023\030\036\007\036\035\036\027\017\016 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.552 0 Td [(U-\022\030\017\021\036\030\017\036\n )0.6(\204\026\027\027\026\226\211\017\021\027\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.58 0 Td (\027\036 )Tj 0.292 Tw -21.132 -1.218 Td (\206\026\031\f\f\024\r\024\n \030\026\f\023\030\036\007\036\035\036\027\017\ \017. \232\036\021\t\030\036\b\023\024\035\034\027\t\036 \021\026\002\035\ \017)Tj 0 Tw (-)Tj 0.536 Tw T* (\006\t \026\027\026\035\017\017\030\024\r\026\035\017\f\034 \007\r\031\f\ \021\024\030\024\027\027\017\n \021\024\004\027\t\n \022\030\017)Tj 0 Tw (-)Tj 0.233 Tw T* [(\021\036\030\017\036\n \205\017\001\036\030\026; )0.5(\n\027\024\020\024\023\024\035\034\027\t\036)]TJ /Span<>> BDC ( )Tj EMC 13.829 0 Td [(\227 \245\262 )0.5(\215\017\030\f\024\027\026 \r\027\036 )]TJ 0.304 Tw -13.829 -1.218 Td (\026\r\017\f\017\n\024\f\021\017 \024\021 \024\032\017\007\026\036\n\t\b\ \027\026\004\036\027\017\005. \202\027\026\035\017 \r\t)Tj 0 Tw (-)Tj 0.239 Tw T* (\032\017\r\026\036\n\024\f\021\017 \023\030\024\017\r\024\007\017\035\026\ \f\034 \023\031\021\036\n \023\024\f\021\030\024\036\027\017\016 \022\030\ \017)Tj 0 Tw (-)Tj 0.16 Tw T* (\r\t\b \025\026\023\035\026\027\026\226\204\036\005\036\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \035\024\020-\030\026\027\020\024\ \r\024\020\024 )Tj 0.281 Tw T* (\021\036\f\021\026 \007\035\016 \f\030\026\r\027\036\027\017\016. \212\035\ \016 \r\t\016\r\035\036\027\017\016 \023\030\036\007\017\022\021\024\030\ \024\r )Tj 0.13 Tw T* (\017\f\b\024\007\024\r \023\030\017\n\036\027\016\035\026\f\034 \023\030\ \024\f\021\026\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\036\027\027\026\016 \002\017)Tj 0 Tw (-)Tj 0.046 Tw T* (\027\026\030\027\026\016 \035\024\020\017\f\021\017\004\036\f\022\026\016\ \030\036\020\030\036\f\f\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\024\n \024\021\027\024\001\036)Tj 0 Tw (-)Tj 0.153 Tw T* [(\027\017\016 )0.5(\001\026\027\f\024\r \(\210\231\) \017)]TJ /Span<>> BDC ( )Tj EMC 8.728 0 Td [(95% \007\024\r\036\030\017\021\036\035\034\027\024\020\024 )0.5(\017\027\021\036\030\r\026\035\026 )]TJ 0.318 Tw -8.728 -1.218 Td (\(\212\230\). \200)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017\r\026\030\017\026\027\021\027\031\033 \n\024\007\036\ \035\034 \r\022\035\033\004\026\035\017 \023\030\036)Tj 0 Tw (-)Tj 0.036 Tw T* (\007\017\022\021\024\030\t \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.036 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,1 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\027\017\r\026\030\017\026\027\021\027\024\n \026\027\026\035\017\036\ ; \022\026)Tj 0 Tw (-)Tj 0.164 Tw T* [(\004\036\f\021\r\024 )0.5(\n\024\007\036\035\017 )0.6(\024\006\036\027\017\r\026\035\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.775 0 Td [(\027\026\004\036\027\017\016\n )0.6(\024\021\027\024\001\036\027\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.552 56.0378 Tm (127)Tj ET endstream endobj 745 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 480.8534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 480.8534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 443.6456 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 443.6456 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 389.5764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.104 Tw 9 0 0 9 119.0551 730.4919 Tm [(AIM: )0.5(to )0.5(com)16(pare )0.5(early )0.5(and )0.6(late )0.5(results )0.5(af)-45.9(ter )0.5(segmental )0.6(and )0.5(e)-15(xtended )0.5(resections )0.5(in )0.5(middle )0.5(third )0.5(transv)13(erse )0.5(colon )]TJ 0 Tw 0 -1.111 TD [(cancer)51.1(.)]TJ 0.186 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a retrospectiv)13(e study included 86 patients with middle third transv)13(erse colon cancer )]TJ 0.073 Tw T* [(who under)-32(w)12(ent resection betw)12.1(een 2017\2312023. P)18(atients w)12(ere divided into segmental resection \(SR\) \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\) and )Tj 0.098 Tw T* [(e)-15(xtended colectom)11.1(y \(EC\) \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(31\) g)14(roups. Intraoperativ)13.1(e parameters, incidence, nature of postoperativ)13(e morbid)]TJ 0 Tw (-)Tj 0.05 Tw 0 -1.111 TD [(ity and histopathological f)-43(indings w)12(ere ev)16(aluated. Late outcomes and functional results w)12.1(ere analysed. S)28(tatistical )]TJ 0.023 Tw 0 -1.111 TD [(analysis included reg)14(ression models to identify com)16(plication p)46(redictors.)]TJ 0.125 Tw T* [(RESUL)30(T)-10(S: postoperativ)13(e com)16(plications in the CP g)14(roup w)12(ere low)12(er than af)-46(ter e)-15(xtended surg)11.9(er)-43(y)]TJ /Span<>> BDC ( )Tj EMC (\227 11/55 \(20%\) )Tj -0.003 Tw T* [(v)13(ersus 13/31 \(41.9%\) cases \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.04\). In multiv)16.1(ar)-37(iate analysis, independent p)46(redictors of an increase in the lik)17(eli)]TJ 0 Tw (-)Tj -0.019 Tw T* [(hood of com)16(plications w)12(ere stapler anastomosis \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9.48; 95% CI: 1.88\23157.66; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.008\) and the pN2 \(odd ratio )Tj -0.023 Tw T* (\(OR\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(3.63; 95% conf)-42.9(idence inter)-42(v)16(al \(CI\): 1.11\23112.34; p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.03\). The v)13(olume of resection had no signif)-43(icant ef)-40(fect )]TJ -0.019 Tw T* [(on the r)-37(isk of com)16(plications \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2.8; 95% CI: 0.97\2318.33; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.11\). With EC, more lym)16(ph nodes w)12(ere remov)13(ed than )]TJ 0.055 Tw T* (with SR)Tj /Span<>> BDC ( )Tj EMC (\227 20)Tj /Span<>> BDC ( )Tj EMC [(\(15.7; 32.2\) v)13(ersus 29)]TJ /Span<>> BDC ( )Tj EMC (\(21; 48\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.005\), while the rate of their metastatic lesion w)13(as 0 \(0; 4\) )]TJ 0.019 Tw T* [(for bo)13.1(th g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.44\), and the 5\231year ov)13(erall sur)-41.9(viv)16(al with a median follow-up of 52 \(34.7; 68.5\) months w)13(as )]TJ -0.006 Tw 0 -1.111 TD [(86% for SR v)13(ersus 78.3% for EC \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.0\) did no)13(t dif)-39.9(fer signif)-43(icantly betw)12(een the g)14(roups. The study of the freq)14(uency )]TJ 0.051 Tw 0 -1.111 TD [(of bow)12.1(el mov)13(ements in the late per)-37(iod w)13(as 2)]TJ /Span<>> BDC ( )Tj EMC [(\(1;2\) times/d)26(ay in bo)13(th g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.97\), as w)11.9(ell as the shape and )]TJ 0.02 Tw T* [(consistency of faeces \(type 3 p)46(rev)16(ailed according to the Br)-37(istol scale)]TJ /Span<>> BDC ( )Tj EMC (\227 31/46)Tj /Span<>> BDC ( )Tj EMC (\(67.4%\) for SR and 20/28)Tj /Span<>> BDC ( )Tj EMC (\(71.4%\) )Tj 0.023 Tw T* (for EC \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\)\) rev)13(ealed no signif)-42.9(icant dif)-39.9(ferences betw)12.1(een the g)14(roups.)]TJ T* [(C)21(ON)22(CLUSION: )0.5(postoperativ)13(e com)16.1(plications in the segmental )0.5(colon resection g)14(roup is low)12(er than in the dilated colon )]TJ 0.08 Tw T* [(g)14(roup. The v)13(olume of surg)12(er)-42.9(y w)13(as no)13(t an independent p)46(redictor of com)16(plications. The lik)17(elihood of their dev)13(elop)]TJ 0 Tw (-)Tj 0.052 Tw T* [(ment w)13(as increased by the use of stapler for anastomosis and the pN2 cr)-36.9(iter)-37(ion. The late results in the g)14(roups did )]TJ 0.023 Tw T* [(no)13(t dif)-40(fer)51.1(.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 505.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colon cancer)61(, segmental resection, e)-15(xtended hemicolectom)11.1(y)41.9(, resection e)-14.9(xtent for transv)13.1(erse colon cancer)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.031 Tc -0.043 Tw -9.871 -2.617 Td [(F)3(O)-4.7(R)8.5( )0.5(C)-17.7(I)-15.7(T)45.2(A)37.4(T)-24.7(I)-1.5(ON:)]TJ /T1_2 1 Tf 0.028 Tc -0.045 Tw 6.325 0 Td [( )0.5(S)0.5(h)2.5(av)-17.2(l)-27(a)-4.2(e)-4.9(v)]TJ /Span<>> BDC 4.001 0 Td ( )Tj EMC 0.216 0 Td [(I)0.5(.)10.4(R)-10.6(.)-12.7(,)10.5( )0.5(S)-1.3(u)3.3(r)-5(o)0.5(v)-7.8(e)-10.2(g)-18.1(i)7.6(n)]TJ /Span<>> BDC 6.313 0 Td ( )Tj EMC 0.216 0 Td [(E)5.2(.)-16(S)1.2(.)-12.7(,)10.5( )0.5(S)-18.5(e)-1.3(r)-5.9(g)-3.6(e)-9.3(y)10.6( )0.5(A)-12.2(.)10.5( )0.5(Fr)-4.9(o)-4.8(l)-10.1(o)0.5(v)21.5(,)10.5( )0.5(M)1(i)7.6(n)-1(g)2.7(a)-16.7(zo)0.6(v)]TJ /Span<>> BDC 13.32 0 Td ( )Tj EMC 0.216 0 Td [(A)-12.2(.)11.3(F)79(.)-12.7(,)10.5( )0.5(B)0.5(l)-12.5(udo)0.5(v)]TJ /Span<>> BDC 4.972 0 Td ( )Tj EMC 0.216 0 Td [(M)3.7(.)23.3(O)22.2(.)-12.7(,)10.5( )0.5(E)3.4(l)-11.6(f)-52.2(i)7.6(m)-1.5(o)0.5(v)-17.6(a)]TJ /Span<>> BDC 6.057 0 Td ( )Tj EMC 0.216 0 Td [(Y)62.1(.)-13(A)-12.2(.)-12.7(,)10.6( K)-9.6(ho)1.6(m)-4.6(y)-13.3(ak)7.1(o)0.5(v)]TJ /Span<>> BDC 6.95 0 Td ( )Tj EMC 0.216 0 Td [(E)5.2(.)-13(A)-12.2(.)-12.7(,)10.5( )0.5(S)-1.2(u)-11.1(s)2(h)2.2(k)7.2(o)0.5(v)]TJ /Span<>> BDC 5.658 0 Td ( )Tj EMC 0.216 0 Td [(O)22.2(.)1(I)0.6(.)28( )]TJ 0.003 Tc -0.035 Tw -55.111 -1.2 Td [(O)-16.7(u)-16(t)-22.2(c)-6.2(o)-8.9(m)-16.3(e)-22.6(s o)-11.9(f)]TJ /Span<>> BDC ( )Tj EMC [(s)-22.6(e)-20.7(g)-8.5(m)-16.4(e)-11.2(n)-17(t)-36.5(a)-11.2(l a)-7.4(n)-14.2(d e)-32.8(x)-44.5(t)-24.4(e)-11.3(n)-14.2(d)-15(e)-20.7(d c)-6.3(o)-15.3(l)-23.4(e)-18.8(c)-41.3(t)-21.6(o)-8.9(m)-15.1(y f)-24.9(o)-11.6(r m)-14.2(i)-8.5(d)-17.4(-)-8(t)-30.5(r)-30.6(a)-7.3(n)-10.9(s)-27.7(v)-18.5(e)-11.8(r)-30(s)-22.6(e c)-6.2(o)-15.4(l)-20.6(o)-8.9(n c)-21.2(a)-7.4(n)-9.7(c)-9.4(e)-11.8(r)30.9(. A)]TJ /Span<>> BDC ( )Tj EMC [(r)-18.8(e)-22.1(t)-30.5(r)-15.5(o)-15.5(s)-9(p)-24.5(e)-18.8(c)-41.2(t)-45.9(i)-14.3(v)-18.4(e s)-29.1(t)-22(u)-10.1(d)-20.2(y)18.3(. )]TJ /T1_0 1 Tf 0.009 Tc -0.009 Tw [(K)10.2(o)-3.8(lo)-3.8(p)-1.4(r)-0.6(ok)-22.9(t)-1.6(o)-3.8(lo)-7(g)-16.9(i)2.9(a)2.1(.)]TJ /T1_2 1 Tf 0.004 Tc -0.036 Tw 49.665 0 Td [( 2)-7.6(0)-2.6(2)5.5(6)21.2(;)11.1(25)2.2(\()38.9(1)45.6(\))15.8(:)22.2(1)1.2(25)-21.4(\226)]TJ 0.023 Tc 0.024 Tw -49.665 -1.2 Td [(1)-7.9(3)7.9(3)6.8(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.6(-)55.2(1)26.9(-)55.1(12)-1.4(5)-23.6(-)55.2(1)-7.9(3)7.9(3)]TJ /T1_1 1 Tf 0.01 Tc 0.087 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( )0.6(\020\036\017)5( )0.5(\013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.092 Tw 10.714 0 Td [( )0.5(\237\020\021\f\020\027\021 )0.6(\002.\206., )0.5(\214\216\221\210 )0.6(\253\001\215\002\037 )0.5(\n\031\f\031\033\032\031\n\023\031\f\031\b\022\022 )0.7(\022\026\027\025\022 )0.6(\003.\001.)]TJ /Span<>> BDC ( )Tj EMC 24.721 0 Td [(\206\013\255\022\200\273 )0.6(\215\022\025\016\030\032\020\021\020 )0.6(\206\031\024\024\022\022, )0.6(\r\f.)]TJ /Span<>> BDC ( )Tj EMC 13.179 0 Td [(\205\020\f\t\026\020 )0.6(\003\030\022\f\t, )0.6(\030.)]TJ /Span<>> BDC ( )Tj EMC 7.37 0 Td (2, )Tj 0.023 Tw -55.989 -1.2 Td (\215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: shavlaev\ _ir@gnck.ru)Tj /T1_1 1 Tf 0.01 Tc -0.012 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.5(F)13(OR)5( )0.5(C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc -0.007 Tw 13.99 0 Td [( )0.5(Islam )0.5(R. )0.5(Shavlaev)63(, )0.5(Ryzhikh )0.5(N)18(ational )0.6(Medical )0.5(R)21(esearch )0.5(Center )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 24.888 0 Td [(Colop)46(roctology)42.1(, )0.5(Salyama )0.5(Adilya )0.6(st., 2, )0.5(Moscow)52.1(, )]TJ 0.023 Tw -38.883 -1.2 Td [(123423, R)22(ussia; e-mail: shavlaev_ir@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 22.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 22.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 25.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 335.1339 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.166 Tw 10 0 0 10 70.8661 310.7779 Tm (\217\026\022 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\ \004\027\024\005 \022\017\001\022\017 \(\217\215\210\025\) \016\r\035\016\ \036\021\f\016 )Tj 0.247 Tw 0 -1.218 TD (\007\024\f\021\026\021\024\004\027\024 \030\036\007\022\024\005 \023\026\ \021\024\035\024\020\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\036\021 \024\022\024\035\024 )Tj -0.016 Tw T* (10% \r\f\036\b \035\024\022\026\004\036\f\021\r\036\027\027\t\b \027\024\ \r\024\024\002\030\026\024\r\026\027\017\005 \021\024\035\f\021\024\005\ )Tj 0.009 Tw T* (\022\017\001\022\017. \212\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\020\024 \r\030\036\n\036\027\017 \r\t\002\ \024\030 \024\002\255\036\n\026 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.27 Tw T* (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \035\024\022\026\035\017\026\006\017\017 )Tj 0.151 Tw T* (\024\023\031\b\024\035\017 \024\f\021\026\036\021\f\016 \023\030\036\007\ \n\036\021\024\n \007\017\f\022\031\f\f\017\005. \222\031\013\036\f\021\r\ \031\036\021 )Tj -0.01 Tw T* (\030\016\007 \027\036\030\036\001\036\027\027\t\b \r\024\023\030\024\f\024\ \r, \026\021\030\031\007\027\016\033\013\017\b \f\021\026\027\007\026\030\ \021\017)Tj 0 Tw (-)Tj 0.04 Tw T* (\026\006\017\033 \035\036\004\036\027\017\016, \024\007\027\017\n \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \016\r\035\016\036\021\f\016 \027\036\004\036\021\ \022\024\036 )Tj -0.034 Tw T* [(\024\023\030\036\007\036\035\036\027\017\036 \f\026\n\024\020\024 \023\024\ \027\016\021\017\016 )0.5(\253\023\024\023\036\030\036\004\027\026\016 \024\002\024\007\024\004\027\ \026\016 )]TJ -0.043 Tw T* (\022\017\001\022\026\273. \222\024\020\035\026\f\027\024 \030\036\022\024\ \n\036\027\007\026\006\017\016\n \212\036\035\034\235\017\005\f\022\024\020\ \024 \022\024\027)Tj 0 Tw (-)Tj 0.13 Tw T* (\f\036\027\f\031\f\026, \253\022 \024\023\031\b\024\035\016\n \023\024\023\ \036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\ \001\022\017 )Tj 0.214 Tw T* (\f\035\036\007\031\036\021 \024\021\027\024\f\017\021\034 \035\033\002\t\ \036 \027\024\r\024\024\002\030\026\024\r\026\027\017\016, \035\024\022\ \026\035\017)Tj 0 Tw (-)Tj 0.044 Tw T* (\024\r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\ \005 \022\017\001\022\036, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033)Tj 0 Tw (-)Tj 0.15 Tw T* (\004\036\027\017\036\n \031\004\026\f\021\022\024\r, \027\026\b\024\007\016\ \013\017\b\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b 10 \f\n \024\021 )Tj 0.226 Tw T* (\023\036\004\036\027\024\004\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\f\036\035\036\036\027\024\004\027\024\020\024 \017\020\017\002\024\r\273\ [1]. \025\030\024\n\036 )Tj -0.034 Tw T* (\021\024\020\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \024\002\255\036\n\026 \030\036\036\022\006\017\017\ , \f\035\036\007\031\036\021 \031\004\017\021\t\r\026\021\034 )Tj 0.022 Tw T* (\021\024\021 \235\026\022\021, \004\021\024 \007\026\027\027\t\005 \f\036\ \020\n\036\027\021 \022\017\001\036\004\027\017\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\220\n\002\030\017\024\020\036)Tj 0 Tw (-)Tj 0.056 Tw T* (\027\036\036 \030\026\r\017\r\026\036\021\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \022\017\001\022\017 \017, \021\036\024\030\036\ \021\017\004\036\f\022\017, )Tj 0.122 Tw T* (\035\017\n\235\024\024\021\021\024\022 \024\021 \027\036\036 \r\024\n\024\ \032\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\024\031\035\t, \035\024\022\026\035\017)Tj 0 Tw (-)Tj 0.274 Tw T* [(\031\033\013\017\036\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 5.605 0 Td [(\002\030\t\032\036\005\022\036 )0.5(\023\030\026\r\t\b )0.5(\024\021\007\036\035\024\r )0.5(\024\002\024\007\024\004\027\024\005 )]TJ 0.256 Tw 17.639 25.574 Td [(\022\017\001\022\017, \022\024\021\024\030\t\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.5(\r\030\036\n\016 \235\024\030\n\026\035\034\027\024 )0.5(\027\036 )]TJ 0.565 Tw T* (\030\026\f\f\n\026\021\030\017\r\026\033\021\f\016 \022\026\022 \030\036\ \020\017\024\027\026\035\034\027\t\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 )Tj 0.133 Tw T* (\035\024\022\026\035\017\026\006\017\017 [2]. \200)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \f\r\016\017, \f\021\024\017\021 \031\023\024\n\016\027\ \031\021\034 \017\f)Tj 0 Tw (-)Tj 0.062 Tw T* [(\f\035\036\007\024\r\026\027\017\036 P)40(ar)-24(k H.M. \(2021\), \020\007\036 \004\026\f\021\024\021\026 \023\024\030\026\ \032\036\027\017\016 )]TJ 0.285 Tw T* (\035\017\n\235\024\031\035\024\r, \030\026\f\023\024\035\024\032\036\027\ \027\t\b \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\031 \023\030\026\r\024\005 \024\002\024)Tj 0 Tw (-)Tj 0.149 Tw T* (\007\024\004\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\r\007\024\001\027\024-\024\002\024\007\024\004\027\024\005\ \026\030\021\036\030\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 )Tj 0.111 Tw T* (\f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\023\036\030\036\ \004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\017\001\022\017\ \007\024\f\021\017)Tj 0 Tw (-)Tj 0.143 Tw T* (\020\026\035\026 32% [3]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\007\036\005\f\021\r\031\033\013\017\n\017 \030\024\f)Tj 0 Tw (-)Tj 0.286 Tw T* [(\f\017\005\f\022\017\n\017 )0.5(\022\035\017\027\017\004\036\f\022\017\n\017 )0.5(\030\036\022\024\n\036\027\007\026\006\017\016\n\017 )0.6(\007\024\023\031\f\021\017)]TJ 0 Tw (-)Tj 0.27 Tw T* (\n\t\n\017 \024\002\255\036\n\026\n\017 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \035\036\004\036\027\017\016 \016\r\035\016\033\021\f\ \016 )Tj 0.411 Tw T* (\030\036\036\022\006\017\016 \023\024\023\036\030\036\004\027\024\005 \024\ \002\024\007\024\004\027\024\005 \022\017\001\022\017, \022\024\021\024\030\ \031\033 )Tj 0.388 Tw T* (\n\024\032\027\024 \f\004\017\021\026\021\034 \253\f\036\020\n\036\027\021\ \026\030\027\024\005\273 \017)Tj /Span<>> BDC ( )Tj EMC (\253\030\026\f\001\017\030\036\027\027\t\036\273 )Tj 0.401 Tw T* (\r\n\036\001\026\021\036\035\034\f\021\r\026: \030\026\f\001\017\030\036\ \027\027\026\016 \023\030\026\r\024\f\021\024\030\024\027\027\016\016 \017\ \035\017 )Tj 0.273 Tw T* (\035\036\r\024\f\021\024\030\024\027\027\016\016 \020\036\n\017\022\024\035\ \220\022\021\024\n\017\016. \215\030\036\007\023\024\004\021\017\021\036\ \035\034\027\t\n )Tj 0.063 Tw T* (\024\002\255\036\n\024\n \027\026\t\r\026\036\021\f\016 \f\031\002\021\024\ \021\026\035\034\027\026\016 \030\036\036\022\006\017\016 \024\002\024\007\ \024\004)Tj 0 Tw (-)Tj 0.078 Tw T* (\027\024\005 \022\017\001\022\017. \210\007\027\026\022\024 \f\021\024\017\ \021 \024\021\n\036\021\017\021\034, \004\021\024 \031\030\024\r\036\027\ \034 \031\002\036)Tj 0 Tw (-)Tj 0.12 Tw T* (\007\017\021\036\035\034\027\024\f\021\017 \030\036\022\024\n\036\027\007\ \026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n\031 \023\031\027\022\021\031)Tj /Span<>> BDC ( )Tj EMC (\227 \222, )Tj 0.1 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\036\027\034 \007\024\f\021\024\r\036\030\027\024\f\021\017\ \007\024\022\026\026\021\036\035\034\f\021\r)Tj /Span<>> BDC ( )Tj EMC (\227 5, \004\021\024 \027\036 )Tj 0.191 Tw T* (\023\024\r\024\035\016\036\021 \f\004\017\021\026\021\034 \220\021\031 \ \030\036\022\024\n\036\027\007\026\006\017\033 \031\002\036\007\017\021\036\ \035\034\027\024\005 )Tj 0.079 Tw T* ([4]. \222)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t, \030\036\036\022\006\017\ \016 \023\024\023\036\030\036\004\027\024\005 \024\002\024\007\024\004)Tj 0 Tw (-)Tj 0.152 Tw T* (\027\024\005 \022\017\001\022\017 \f\004\017\021\026\036\021\f\016 \n\036\ \027\036\036 \021\030\026\r\n\026\021\017\004\027\024\005 \023\030\024\006\ \036\007\031)Tj 0 Tw (-)Tj 0.047 Tw T* (\030\024\005, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\t\n\017 \024\023\036\030\026\006\017\016\ \n\017 [5], )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_1 1 Tf 0 Tw 9 0 0 9 73.5728 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7776 56.0378 Tm (126)Tj ET endstream endobj 34 0 obj <> endobj 35 0 obj <> endobj 36 0 obj <> endobj 37 0 obj <> endobj 38 0 obj <> endobj 772 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 773 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 774 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 775 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 776 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 784 0 obj [787 0 R] endobj 785 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022\005\017\016\204\n\005\004\t\t\025\221 \005\004\ \212\004\r\n\n \224\005\n\022\005\017\r\004 \016\005\004\202\t\004\221 \ )]TJ 0 -1 TD [(\026\005\004\026\n \224\025\224\004\005\004\225\t\025\221 \025\255\025\202\ \025\225\t\025\221 \r\n\204\r\n. \033\004\026\005\025\016\224\004\r)-10(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 41.201 1 Td [(Outcomes of\022segmental and e)21(xtended colectom)21(y )]TJ 19.272 0 Td ( )Tj -21.154 -1 Td [(for mid-tr)21(ans)21(v)12(er)20(se colon cancer)52(. A\022r)31(etr)20(ospectiv)12(e study)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 235.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 235.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 198.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 198.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-125-133)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 65.8878 695.3259 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \016\004\013)10(\024\004\t\026)11(\017\005\t\025\221 \n\022)-23.3(\005\017\016\204\n\005\004\t\t\025\221 \005\004\212\004\r\n\n )]TJ -0.859 -1.105 Td [(\224\005\n\022)-23.3(\005\017\r\004 \016\005\004\202\t\004\221 \026\005\004\026\n \224\025\224\ \004\005\004\225\t\025\221 \025\255\025\202\025\225\t\025\221 \r\n\204\r\ \n. )]TJ 5.022 -1.105 Td [(\033\004\026\005\025\016\224\004\r)-9.9(\026\n\b\t\025\004 \n\016\016)-10(\020\004\202\025\b\017\t\n\004)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\222\017\b\020\017\004\b\022)-23.2(\030.\033)124(., \001\002\005\025\b\004\013\n\t\022)-23.2(\240.\001., \210\005\025\020\025\b\022)-23.3(\001.\f)-30.9(., \235\n\t\013)10(\017\212\025\b\022)-23.2(\f)-31(.\210., \006\020\002\202\025\b\022)-23.2(\235.\036., )]TJ 0 -1.143 TD [(\240\020\216\n\024\025\b\017\022)-23.2(\207.\f)-31(., \205\025\024\213\r)10(\025\b\022)-23.2(\240.\f)-31(., \001\002\204\r)10(\025\b\022)-23.3(\036.\030.)]TJ 10 0 0 10 42.5197 595.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.2(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ 0 -1.2 TD [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0.09 Tw 9 0 0 9 90.7087 564.6488 Tm (\035\027\007\027\025\022\027 \032\020\n\020 \024\032\027\030\025\027\235\ \023\032\027\023\022 \033\031\033\027\032\027\007\025\031\235 \031\240\031\ \030\031\007\025\031\235 \n\022\213\n\022 \t\021\f\t\027\023\024\t \020\n\ \023\r\020\f\017\025\031\235 \033\032\031\240\f\027\026\031\235 \n\031\f\ \031\033\032\031\n\023\031)Tj 0 Tw (-)Tj 0 -1.111 TD (\f\031\b\022\022.)Tj 0.02 Tw T* (\037\036\035\034: \024\032\020\021\025\027\025\022\027 \025\027\033\031\024\ \032\027\030\024\023\021\027\025\025\013\200 \022)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\020\f\027\025\025\013\200 \032\027\016\r\f\017\023\020\023\031\ \021 \033\031\024\f\027 \024\027\b\026\027\025\023\020\032\025\013\200 \022\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\024\213\022\032\027\025\025\013\200 \032\027\016\027\n)Tj 0 Tw (-)Tj 0.023 Tw T* (\006\022\235 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\032\020\n\027 \024\032\027\030\025\027\235 \023\032\027\023\022 \033\031\ \033\027\032\027\007\025\031\235 \031\240\031\030\031\007\025\031\235 \n\ \022\213\n\022.)Tj 0.231 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC [(\215\036\217\220\201: \033\032\031\021\027\030\027\025\031 \032\027\023\ \032\031\024\033\027\n\023\022\021\025\031\027 )0.5(\022\024\024\f\027\030\031\021\020\025\022\027 \032\027\016\r\f\017\023\020\ \023\031\021 \f\027\007\027\025\022\t 86 \033\020\006\022\027\025\023\031\ \021, )]TJ 0.096 Tw 0 -1.111 TD (\031\033\027\032\022\032\031\021\020\025\025\013\200 \021)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\022\031\030 \024)Tj /Span<>> BDC ( )Tj EMC (\t\025\021\020\032\t 2017 \033\031)Tj /Span<>> BDC ( )Tj EMC (\t\025\021\020\032\017 2023 \b\b. \004\020\006\022\027\025\023\013 \032\020\ \016\030\027\f\027\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\013 \024\027\b\026\027\025\023\020\032\025\031\235 )Tj 0.149 Tw 0 -1.111 TD (\032\027\016\027\n\006\022\022 \(\205\206\) \033\031\033\027\032\027\007\ \025\031\235 \031\240\031\030\031\007\025\031\235 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (55\) \022)Tj /Span<>> BDC ( )Tj EMC (\032\020\024\213\022\032\027\025\025\031\235 \032\027\016\027\n\006\022\022\ \(\206\206\) \031\240\031\030\031\007\025\031\235 \n\022\213\n\022 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (31\). )Tj 0.005 Tc 0.35 Tw T* [(\217\006\027\025\022\021\020\f\022\024\017 )0.5(\022\025\023\032\020\031\033\027\032\020\006\022\031\025\025\013\027 )0.5(\033\020\032\020\026\027\023\032\013, \007\020\024\023\031\023\020 \022)]TJ /Span<>> BDC ( )Tj EMC 26.285 0 Td [(\200\020\032\020\n\023\027\032 \033\031\024\f\027\031\033\027\032\020\006\ \022\031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235.)5.1( )]TJ 0.349 Tw -26.285 -1.111 Td [(\004)0.5(\032)0.5(\031)0.5(\021)0.5(\031)0.5(\030\022)0.5(\f)0.5(\031)0.5(\024)0.5(\017)0.5( \022)0.5(\016)0.5(\r\007)0.5(\027)0.5(\025)0.5(\022)0.5(\027)0.5( \032)0.5(\027)0.5(\016)0.5(\r\f)0.5(\017)0.5(\023)0.5(\020)0.5(\023)0.5(\031)0.5(\021)0.5( \033)0.5(\020\023)0.5(\031)0.5(\026)0.5(\031)0.5(\032)0.5(\203)0.5(\031)0.5(\f)0.5(\031)0.5(\b\022)0.5(\007)0.5(\027)0.5(\024)0.5(\n)0.5(\031)0.5(\b\031)0.5( \022)0.5(\024)0.5(\024)0.5(\f)0.5(\027)0.5(\030)0.5(\031)0.5(\021)0.5(\020)0.5(\025\022)0.5(\t)0.5( \031)0.5(\033)0.5(\027)0.5(\032)0.5(\020)0.5(\006\022)0.5(\031)0.5(\025)0.5(\025)0.5(\013)0.5(\200)0.5( \033)0.5(\032\027)0.5(\033)0.5(\020)0.5(\032)0.5(\020)0.5(\023)0.5(\031)0.5(\021)0.5(.)5( )]TJ 0 Tc 0.077 Tw T* (\002\016\r\007\020\f\022\024\017 \031\023\030\020\f\027\025\025\013\027 \ \032\027\016\r\f\017\023\020\023\013 \f\027\007\027\025\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\203\r\025\n\006\022\031\025\020\f\017\025\013\027 \022\024\200\031\030\013\ \031\033\027\032\020\006\022\235 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\027\030\022\n\023\031\032\013 \032\020\016\021\022\023\022\t )Tj 0 Tw T* (\031\024\f\031\255\025\027\025\022\235.)Tj 0.026 Tw 0 -1.111 TD [(\206\036\207\210\035\034\003\201: \007\020\024\023\031\023\020 \033\031\ \024\f\027\031\033\027\032\020\006\022\031\025\025\013\200 )0.5(\031\024\f\031\255\025\027\025\022\235 \021)]TJ /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \205\206 \240\013\f\020 \025\022\255\027, \007\027\026\ \033\031\024\f\027 \032\020\024\213\022\032\027\025\025\013\200 \031\033\ \027)Tj 0 Tw (-)Tj 0.046 Tw 0 -1.111 TD (\032\020\006\022\235)Tj /Span<>> BDC ( )Tj EMC (\227 11/55 \(20%\) \033\032\031\023\022\021 13/31 \(41,9%\) \024\f\r\007\ \020\027\021, \024\031\031\023\021\027\023\024\023\021\027\025\025\031\(\ p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,04\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\r\f\017\023\022\021\020\032\022\020\025\023\025\031\026 )Tj 0.096 Tw T* [(\020\025\020\f\022\016\027 )0.5(\025\027\016\020\021\022\024\022\026\013\026\022 )0.5(\033\032\027\030\022\n\023\031\032\020\026\022 )0.5(\r\021\027\f\022\007\027\025\022\t )0.6(\021\027\032\031\t\023\025\031\024\023\022 )0.6(\032\020\016\021\022\023\022\t )0.5(\031\024\f\031\255\025\027\025\022\235 )0.5(\024\023\020\f\022: )0.5(\203\031\032\026\022\032\031\021\020)]TJ 0 Tw (-)Tj 0.067 Tw T* [(\025\022\027 \020\025\020\024\023\031\026\031\016\020 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC [(\033\031\026\031\212\017\005 )0.5(\024\213\022\021\020\005\212\022\200 \020\033\033\020\032\020\023\031\021\ )0.5(\(\031\023\025\031\213\027\025\022\027 )0.5(\213\020\025\024\031\021 \(\217\237\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9,48; 95% \030\031\021\027\032\022\023\027\f\017\025\013\235 )Tj 0.101 Tw T* (\022\025\023\027\032\021\020\f \(\220\002\): 1,88\23157,66; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \022)Tj /Span<>> BDC ( )Tj EMC (\n\032\022\023\027\032\022\235 pN2 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (3,63; 95% \220\002: 1,11\23112,34; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \217\240\236\027\026 )Tj 0.14 Tw T* [(\032\027\016\027\n\006\022\022 )0.6(\025\027 )0.5(\031\n\020\016\013\021\020\f )0.6(\024\023\020\023\022\024\023\022\007\027\024\n\022 )0.6(\016\025\020\007\022\026\031\b\031 )0.6(\021\f\022\t\025\022\t )0.6(\025\020)]TJ /Span<>> BDC ( )Tj EMC 26.491 0 Td [(\032\022\024\n )0.6(\032\020\016\021\022\023\022\t )0.6(\031\024\f\031\255\025\027\025\022\235 )0.6(\(\217\237)]TJ /Span<>> BDC ( )Tj EMC 14.045 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.872 0 Td [(2,8; )0.5(95% )]TJ 0.013 Tw -41.408 -1.111 Td (\220\002: 0,97\2318,33; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,11\). \004\032\022)Tj /Span<>> BDC ( )Tj EMC (\206\206 \r\030\020\f\t\f\031\024\017 \240\031\f\017\213\027 \f\022\026\203\ \031\r\016\f\031\021, \007\027\026 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\205\206)Tj /Span<>> BDC ( )Tj EMC (\227 20)Tj /Span<>> BDC ( )Tj EMC (\(15,7; 32,2\) \033\032\031\023\022\021 29)Tj /Span<>> BDC ( )Tj EMC (\(21; )Tj 0.027 Tw T* (48\) \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005\), \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \007\020\024\023\031\023\020 \022\200 \026\027\023\020\024\ \023\020\023\022\007\027\024\n\031\b\031 \033\031\032\020\255\027\025\022\ \t)Tj /Span<>> BDC ( )Tj EMC (\227 0 \(0; 4\) \030\f\t \031\240\027\022\200 \b\032\r\033\033 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,44\), )Tj 0.008 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (5-\f\027\023\025\t\t \031\240\212\020\t \021\013\255\022\021\020\027\026\ \031\024\023\017 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\026\027\030\022\020\025\027 \033\032\031\024\f\027\255\027\025\025\031\024\ \023\022 \021)Tj /Span<>> BDC ( )Tj EMC (52 \(34,7; 68,5\) \026\027\024\t\006\020 \024\031\024\023\020\021\022\f\020\ 86% \030\f\t )Tj 0 Tw 0 -1.111 TD (\205\206 \033\032\031\023\022\021 78,3% \030\f\t \206\206 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\) \026\027\255\030\r \b\032\r\033\033\020\026\022 \024\023\020\023\022\ \024\023\022\007\027\024\n\022 \016\025\020\007\022\026\031 \025\027 \032\ \020\016\f\022\007\020\f\022\024\017. \002\016\r\007\027\025\022\027 \007\ \020\024\023\031)Tj (-)Tj 0.096 Tw 0 -1.111 TD (\023\013 \030\027\203\027\n\020\006\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\031\023\030\020\f\027\025\025\031\026 \033\027\032\022\031\030\027)Tj /Span<>> BDC ( )Tj EMC (\227 \033\031)Tj /Span<>> BDC ( )Tj EMC (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\) \032\020\016\020/\024\r\023\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\027\022\200 \b\032\r\033\033 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,97\), \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \203\031\032\026\013 )Tj 0.037 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 0.769 0 Td [(\n\031\025\024\022\024\023\027\025\006\022\t )0.5(\n\020\f\020 )0.5(\(\033\032\027\031\240\f\020\030\020\f \023\022\033 )0.5(3 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 17.313 0 Td [(\024\031\031\023\021\027\023\024\023\021\022\022 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 7.221 0 Td [(\221\032\022\024\023\031\f\017\024\n\031\235 )0.5(\213\n\020\f\031\235)]TJ /Span<>> BDC ( )Tj EMC 9.497 0 Td [(\227 )0.5(31/46)]TJ /Span<>> BDC ( )Tj EMC (\(67,4%\) \030\f\t \205\206 )Tj 0.023 Tw -34.799 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC (20/28)Tj /Span<>> BDC ( )Tj EMC (\(71,4%\) \030\f\t \206\206 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\)\) \025\027 \021\013\t\021\022\f\031 \024\023\020\023\022\024\023\022\ \007\027\024\n\022 \016\025\020\007\022\026\013\200 \032\020\016\f\022\007\ \022\235 \026\027\255\030\r \b\032\r\033\033\020\026\022.)Tj 0.008 Tc 0.35 Tw T* (\207\003\202\035\224\232\036\001\002\036: \007\020\024\023\031\023\020 \032\ \020\016\021\022\023\022\t \033\031\024\f\027\031\033\027\032\020\006\022\ \031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235 \021)Tj /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\027 \024\027\b\026\027\025\023\020\032\025\031\235 \032\ \027\016\027\n\006\022\022)8( )]TJ 0 Tc 0.132 Tw T* [(\033\031\033\027\032\027\007\025\031\235 )0.5(\031\240\031\030\031\007\025\031\235 )0.5(\n\022\213\n\022 \025\022\255\027, )0.5(\007\027\026 \021)]TJ /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\027 )0.5(\032\020\024\213\022\032\027\025\025\013\200. )0.5(\217\240\236\027\026 )0.5(\031\033\027\032\020\006\022\022 \025\027 )0.5(\t\021\f\t\f\024\t \025\027\016\020\021\022\024\022\026\013\026 )]TJ 0.007 Tw T* (\033\032\027\030\022\n\023\031\032\031\026 \032\020\016\021\022\023\022\t\ \031\024\f\031\255\025\027\025\022\235. \211\027\032\031\t\023\025\031\024\ \023\017 \022\200 \032\020\016\021\022\023\022\t \033\031\021\013\213\020\ \f\031 \022\024\033\031\f\017\016\031\021\020\025\022\027 \024\213\022\021\ \020\005\212\022\200 \020\033\033\020)Tj 0 Tw (-)Tj 0.058 Tw T* (\032\020\023\031\021 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\203\031\032\026\022\032\031\021\020\025\022\022 \026\027\255\n\022\213\027\ \007\025\031\b\031 \020\025\020\024\023\031\026\031\016\020 \022)Tj /Span<>> BDC ( )Tj EMC (\n\032\022\023\027\032\022\235 pN2. \217\023\030\020\f\027\025\025\013\027\ \032\027\016\r\f\017\023\020\023\013 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 )Tj 0.023 Tw T* (\025\027 \032\020\016\f\022\007\020\f\022\024\017.)Tj /T1_2 1 Tf 0.01 Tc 0.002 Tw 8 0 0 8 42.5596 269.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.007 Tw 8.477 0 Td ( \032\020\n \031\240\031\030\031\007\025\031\235 \n\022\213\n\022, \024\027\ \b\026\027\025\023\020\032\025\020\t \032\027\016\027\n\006\022\t, \032\020\ \024\213\022\032\027\025\025\020\t \b\027\026\022\n\031\f\204\n\023\031\026\ \022\t, \031\240\236\027\026 \032\027\016\027\n\006\022\022 \033\032\022\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\n\027 \033\031\033\027\032\027\007\025\031\235 )Tj 0.023 Tw -8.482 -1.2 Td (\031\240\031\030\031\007\025\031\235 \n\022\213\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.019 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.9( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.009 Tc -0.035 Tw 8.907 0 Td ( \231\026\r\035\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\217., \222\031\030\024\r\036\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\213.\222., \205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\202., \204\017\027\020\026\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\205., \207\035\031\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\210., \213\035\235\017\n\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\224.\202., \216\024\n\016\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\202., \222\031\001\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\210.\230.)9( )]TJ 0.022 Tc -8.912 -1.2 Td (\217\036\031\035\034\021\026\021\t \f\036\020\n\036\027\021\026\030\027\ \024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\001\017\030\036\027\027\024\005 \030\036\036\022\006\017\017\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\022\036 \f\030\036\007\027\036\005 \021\030\036\021\017 \023\024\ \023\036\030\036\004\027\024\005 \024\002\024\007\024\004\027\024\005 \022\ \017\001\022\017. \217\036\021\030\024\f\023\036\022\021\017\r\027\024\036\ \017\f\f\035\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (\007\024\r\026\027\017\036. )Tj /T1_1 1 Tf 4.19 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (125\226133. https://doi.org/10.33878/2073-7556-2026-25-1-125-133)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 82.3034 172.0331 Tm [(Outcomes of\022)-23.3(segmental and e)21(xtended colectom)21(y for )]TJ 0.436 -1.167 Td [(mid-tr)21(ans)21.1(v)12(er)20(se colon cancer)52.1(. A\022)-23.3(r)31(etr)20(ospectiv)12.1(e study)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 126.5292 Tm [(Islam\022)-23.2(R.\022)-23.3(Shavlae)11(v)21(, Ev)10(genii\022)-23.2(S.\022)-23.3(Sur)20(ov)12(egin, Ser)31(gey\022)-23.3(A)-31(.\022)-23.3(Fr)20.1(olov)21(, Air)21(at\022)-23.3(F)94(.\022)-23.3(Minga)20.1(z)10(ov)21(, )]TJ 0 -1.143 TD [(Maxim\022)-23.2(O.\022)-23.3(Bludov)21(, Y)40(ulia\022)-23.3(A)-31(.\022)-23.3(Elf)-21(imov)10.1(a, Ev)10(geniy\022)-23.3(A)-31(.\022)-23.2(Kh)11(om)21(y)21(ak)11(ov)21(, Oleg\022)-23.3(I.\022)-23.3(Sushk)11.1(ov)]TJ 10 0 0 10 42.5197 92.86 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21.1(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 573.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 564.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 505.4397 56.0378 Tm (125)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 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(\022\026\032)Tj 0 Tw (-)Tj 0.106 Tw 0 -1.218 TD (\007\024\020\024 \023\016\021\024\020\024 \023\026\006\017\036\027\021\026\ \n\024\032\036\021 \002\t\021\034 \007\024\f\021\017\020\027\031\021 \023\ \024\035\027\t\005 )Tj 0 Tw T* (\024\021\r\036\021 \024\023\031\b\024\035\017.)Tj 0.014 Tw T* (\222\030\036\007\017 \024\020\030\026\027\017\004\036\027\017\005 \017\f\ \f\035\036\007\024\r\026\027\017\016 \f\021\024\017\021 \r\t\007\036\035\ \017\021\034 \024\021)Tj 0 Tw (-)Tj 0.086 Tw T* (\f\031\021\f\021\r\017\036 \024\f\035\036\023\035\036\027\017\016, \004\021\ \024 \n\024\020\035\024 \023\024\r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\031\002\255\036\022)Tj 0 Tw (-)Tj -0.025 Tw T* (\021\017\r\027\031\033 \024\006\036\027\022\031 \021\024\022\f\017\004\027\ \024\f\021\017 \035\031\004\036\r\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017. )Tj 0.18 Tw 0 -1.218 TD [(\230\f\f\035\036\007\024\r\026\027\017\036 \023\030\024\r\024\007\017\035\ \024\f\034 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\031\022\024\023\030\024\235\017\035\034\027\024\n )0.5(\f\023\036)]TJ 0 Tw (-)Tj 0.291 Tw 0 -1.218 TD (\006\017\026\035\017\017\030\024\r\026\027\027\024\n \006\036\027\021\030\ \036, \004\021\024 \n\024\032\036\021 \024\020\030\026\027\017\004\017\r\ \026\021\034 )Tj 0.117 Tw T* (\024\002\024\002\013\026\036\n\024\f\021\034 \030\036\031\035\034\021\026\ \021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \001\017\030\024\022\031\033 \023\024\023\031)Tj 0 Tw (-)Tj 0.224 Tw T* (\035\016\006\017\033. \221\026\022\032\036 \f\035\036\007\031\036\021 \024\ \021\n\036\021\017\021\034 \027\036\002\024\035\034\001\024\005 \023\036\ \030\017\024\007 )Tj -0.043 Tw T* (\027\026\002\035\033\007\036\027\017\016 \023\026\006\017\036\027\021\024\ \r, \004\021\024 \027\036 \007\024\f\021\026\021\024\004\027\024 \007\035\ \016 \024\006\036\027\022\017 )Tj 0 Tw T* (\024\021\007\026\035\036\027\027\t\b \024\027\022\024\035\024\020\017\004\ \036\f\022\017\b \030\036\031\035\034\021\026\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 554.3378 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.019 Tw 10 0 0 10 42.5197 529.9818 Tm [(\025\024\030\024\021\022\017\005 )0.5(\022\031\030\f \035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 \f)]TJ /Span<>> BDC ( )Tj EMC 14.176 0 Td (\022\031\030\f\024\n \022\024\027\f\024\035\017\007\017)Tj 0 Tw (-)Tj -0.033 Tw -14.176 -1.218 Td (\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\017 \f\ \024\023\024\f\021\026\r\017\n \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \023\024\035\027\t\b )Tj 0.055 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021\r\036\021\024\r \024\023\031\b\024)Tj 0 Tw (-)Tj 0.177 Tw T* (\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005 \b\017\n\017\ \024\035\031\004\036\r\024\005 )Tj 0 Tw T* (\021\036\030\026\023\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\024\n \022\024\027\f\024\035\017\007\017\030\031\033\013\036\ \005 \b\017\n\017\024\021\036\030\026\023\017\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.243 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.8()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.4(\016)13.7(:)]TJ /T1_4 1 Tf -0.003 Tc 0.246 Tw [( \003)-20.4(\f\027\n)6.3(\024)6.8(\027)-3.9(\027)3.6(\021)]TJ /Span<>> BDC 19.73 0 Td ( )Tj EMC [(\215)16.4(.)25.5(\211)21.3(.)4.8(,)-3( )]TJ -0.029 Tc 0.029 Tw -19.73 -1.218 Td [(\214)-19.1(\020)-24.6(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 3.841 0 Td ( )Tj EMC [(\206)64.9(.\002.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.841 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.8(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw [( \214)-19.1(\020)-24.5(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 16.813 0 Td ( )Tj EMC [(\206)64.9(.\002.)]TJ /T1_1 1 Tf 0.018 Tc 1.544 Tw 6.431 30.445 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.7(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf -0.029 Tc 1.591 Tw 12.911 0 Td [( \214)-19.1(\020)-24.6(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 5.636 0 Td ( )Tj EMC [(\206)64.9(.\002.)-21.2(,)-29( )]TJ -0.01 Tc 0.01 Tw -18.547 -1.218 Td [(\221)-5(\020)-15.2(\f\n)2.7(\020)-8.2(\032)-9.9(\031\021)]TJ /Span<>> BDC 3.81 0 Td ( )Tj EMC [(\003)-12.3(.)-2.7(\003)-12.3(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -3.81 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw 7.694 0 Td [( \214)-19.1(\020)-24.6(\235)-25.5(\016)-24.1(\r)-5.2(\f)-19.4(\022)-21.8(\025)]TJ /Span<>> BDC 4.074 0 Td ( )Tj EMC [(\206)64.9(.\002.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -11.767 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \003)-27.3(\f)-6.7(\027)-7.1(\n)-0.7(\024\027)-10.9(\027)-3.4(\021)]TJ /Span<>> BDC 11.023 0 Td ( )Tj EMC [(\215)9.4(.)18.5(\211)14.4(.)-2.2(,)-10( \206)13.8(\013)-8.3(\240)-5.3(\020)-5.1(\n\031\021)]TJ /Span<>> BDC 5.844 0 Td ( )Tj EMC [(\036)12.8(.)19.3(\216)112(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -16.867 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.124 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.3(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf -0.005 Tc 0.129 Tw [( M)5.4(i)3(kha)-7(i)2.4(l)]TJ /Span<>> BDC 17.13 0 Td ( )Tj EMC [(V)48.1(.)]TJ /Span<>> BDC 1.079 0 Td ( )Tj EMC [(A)-1.3(le)-5.2(k)-22.5(se)-11.2(e)-9(v)28.6(,)-5( )]TJ -0.01 Tc 0.01 Tw -18.21 -1.218 Td [(Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 2.583 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -3.447 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.01 Tc 0.01 Tw -15.798 -1.218 Td [(Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 2.583 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_1 1 Tf -0.007 Tc 1.421 Tw -3.447 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf 0 Tc 1.414 Tw 10.502 0 Td [( R)10.1(a)-3(s)9.6(h)6.2(i)3(d)]TJ /Span<>> BDC ( )Tj EMC [(I)2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(F)25.4(a)-5.9(y)-2.5(z)13(u)2.8(l)4.3(i)8.4(n)-5.9(, )]TJ 0 Tw -10.502 -1.218 Td [(A)4.8(r)-38.3(t)-30(y)0.9(om)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(al)-6.3(k)15.8(ar)2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0 -1.218 TD [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( Ra)-13(sh)-3.8(i)-6.9(d)]TJ /Span<>> BDC 10.729 0 Td ( )Tj EMC [(I)-7.6(.)]TJ /Span<>> BDC 0.864 0 Td ( )Tj EMC [(F)15.4(a)-15.9(y)-12.4(z)3(u)-7.2(l)-5.7(i)-1.6(n)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -11.593 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( M)10.5(i)7.9(k)5.3(h)4.8(a)-1.9(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.9(ek)-17.4(s)4.9(e)-6.2(e)-4(v)33.6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)-8.9(y)6.9(ba)1.7(k)12.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0 Tw T* (\205\026\005\031\035\017\027 \217.\230.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0003-0719-7910)Tj T* (\202\035\036\022\f\036\036\r \204.\200.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* (\217\t\002\026\022\024\r \213.\206.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj T* (\207\026\035\022\026\030\024\r \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0001-7342-5753)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(R)-10(ashid I. F)20.1(a)15(yzul)-31(in)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-0719-7910)Tj T* [(Mikhail V. Alek)-9.9(seev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3399-0608)Tj T* [(Ev)-21(geny G. R)-19.9(ybakov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3919-9067)Tj T* [(Ar)-22(t)-9.9(yom A. Balk)-16.9(ar)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7342-5753)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 383.8459 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.004 Tw 8 0 0 8 42.5197 371.0112 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)35(udmir)]TJ /Span<>> BDC ( )Tj EMC [(EB, P)40(al)56(t)15(a)]TJ /Span<>> BDC ( )Tj EMC [(M, W)-16(ille)-11.9(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(CG, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)17(t)15(al neoad)17(juv)-14.9(ant t)-13(her)-33(apy for )]TJ -0.019 Tw -1.296 -1.25 Td [(r)-24(ec)-16(t)15.1(al cancer: An)]TJ /Span<>> BDC ( )Tj EMC [(emer)-32(ging opt)-32(ion. )]TJ /T1_4 1 Tf 0 Tw (Cancer)Tj /T1_1 1 Tf -0.019 Tw [(. 2017 Ma)15(y 1;123\(9\):1497\226)]TJ 0.023 Tw 0 -1.25 TD [(1506. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/cncr.30600)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( Epub 2017 Mar 10. PMID: 28295220.)Tj 0.304 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(K)-16(asi)]TJ /Span<>> BDC ( )Tj EMC [(A, A)-13.9(bbasi)]TJ /Span<>> BDC ( )Tj EMC [(S, Hand)42(a)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)45(o)17(t)15(al Neoad)17(juv)-14.9(ant T)47(her)-33(apy )]TJ 0.018 Tc 0.66 Tw -1.296 -1.25 Td [(vs S)14.8(t)14.9(and)41.8(ar)-24.2(d T)46.8(her)-33.2(apy in L)34.8(o)-16.2(call)34.8(y A)14.8(d)-17.1(v)-15.2(anced R)12.8(ec)-16.1(t)14.8(al Cancer:)18( )]TJ 0 Tc 0.302 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC [(Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_4 1 Tf [(J)30(AMA N)18(etw Open)]TJ /T1_1 1 Tf (. 2020 )Tj 0.074 Tw T* [(Dec 1;3\(12\):e2030097. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1001/jamane)-12(t)-32(w)-13.9(or)-24(kopen.2020.30097)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* (PMID: 33326026; PMCID: PMC7745099.)Tj 0.146 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(ok)-17(as)]TJ /Span<>> BDC ( )Tj EMC [(E, All)16(g\344uer)]TJ /Span<>> BDC ( )Tj EMC [(M, P)10(ol)-16(a)15(t)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ger)-15.9(man R)13(ec)-16(t)15(al Cancer S)15(tud)17.1(y )]TJ 0.01 Tc 0.379 Tw -1.296 -1.25 Td [(G)19.8(r)-32.1(oup. R)-10.2(and)-16.2(omized Phase II T)49.8(r)-37.2(ial of)]TJ /Span<>> BDC ( )Tj EMC [(Chemor)-33.1(adio)16.8(t)-13.1(her)-33.1(apy Pl)34.8(us)10( )]TJ 0.001 Tc 0.35 Tw T* [(Induc)-16.4(t)-32.4(ion or Consol)-31.4(id)41.6(a)14.6(t)-32.3(ion Chemo)16.7(t)-13.4(her)-33.4(apy as T)44.6(o)16.7(t)14.6(al Neoad)16.6(juv)-15.4(ant)1( )]TJ 0 Tc 0.036 Tw T* [(T)47(her)-33(apy for L)35(o)-16(call)35(y A)15(d)-17(v)-14.9(anced R)13(ec)-16(t)15(al Cancer: C)20(A)15(O/ARO/AIO-12. )]TJ /T1_4 1 Tf (J Clin )Tj 0 Tw T* (Oncol.)Tj /T1_1 1 Tf 0.194 Tw [( 2019 Dec 1;37\(34\):3212\2263222. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1200/JC)13(O.19.00308)]TJ 0 0 0 1 k /GS1 gs ( )Tj 0.023 Tw T* [(Epub 2019 Ma)15.1(y 31. PMID: 31150315.)]TJ 0.002 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bahad)-16(oer)]TJ /Span<>> BDC ( )Tj EMC [(RR, Dijk)-10(str)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(EA, v)-15(an Et)-30(ten)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. RAPIDO coll)-16(abor)-33(a)15(t)-32(i)-15.9(ve )]TJ 0.096 Tw -1.296 -1.25 Td [(invest)-31.9(iga)15(t)17(or)-10(s. S)-15.9(hor)-22(t-cour)-10(se r)-33(adio)17(t)-12.9(her)-33(apy foll)30.1(o)-14(wed b)12(y chemo)17(t)-13(her)-32.9(apy )]TJ 0.109 Tw T* [(befor)-24(e t)17(o)17(t)15(al mesor)-24(ec)-16(t)15(al e)-18(x)-13(c)-23.9(ision \(TME\) ver)-10(sus p)25(r)-24(eoper)-33(a)15(t)-31.9(i)-16(ve chemo)]TJ 0 Tw (-)Tj 0.188 Tw T* [(r)-33(adio)17(t)-12.9(her)-33(apy, TME, and )0.5(opt)-32(ional ad)17(juv)-15(ant )0.5(chemo)17(t)-13(her)-32.9(apy in l)30(o)-16(call)35(y )]TJ 0.133 Tw T* [(ad)-17(v)-15(anced r)-23.9(ec)-16(t)15(al cancer \(RAPIDO\): a)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omised, open-l)-16(abel, phase )]TJ 0.17 Tw T* [(3 tr)-37(ial. )]TJ /T1_4 1 Tf (Lancet Oncol.)Tj /T1_1 1 Tf [( 2021 Jan;22\(1\):29\22642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-)Tj 0.001 Tc -0.001 Tw T* [(2)0.5(04)0.5(5\()0.5(2)0.5(0\))0.5(30)0.5(55)0.5(5)0.5(-6)]TJ 0 0 0 1 k /GS1 gs 0.349 Tw 7.1 0 Td [( E)0.5(pu)0.5(b 2)0.5(02)0.5(0)0.5( De)0.5(c 7)0.5(.)0.5( E)0.5(r)-23.5(r)-32.5(a)15.4(t)0.5(u)0.5(m i)0.5(n)0.5(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw ( )Tj /T1_1 1 Tf 0.001 Tc 0.349 Tw 14.656 0 Td [(L)-31.5(an)0.5(c)0.5(e)-11.6(t)0.5( O)0.5(nc)0.5(ol)0.5(.)1( )]TJ 0 Tc 0.268 Tw -21.756 -1.25 Td [(2021 F)10(eb;22\(2\):e42. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/S1470-2045\(20\)30781-6)Tj 0 0 0 1 k /GS1 gs 0.268 Tw ( PMID: )Tj 0 Tw T* (33301740.)Tj -0.006 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Cl)-16(av)-15.9(ien)]TJ /Span<>> BDC ( )Tj EMC [(P)25.1(A, Bar)-24(kun)]TJ /Span<>> BDC ( )Tj EMC [(J, de Ol)-31(i)-16(veir)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(ML, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(Cl)-16(av)-15.9(ien-Dind)-16(o cl)-16(as)]TJ 0 Tw (-)Tj 0.041 Tw -1.296 -1.25 Td [(sif)-28(ica)15(t)-31.9(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 5.219 0 Td [(sur)-32(gical )0.6(com)10(pl)-31(ica)15(t)-31.9(ions: )0.5(f)-28(i)-16(ve-year )0.7(e)-18(xper)-37(ience. )]TJ /T1_4 1 Tf 18.563 0 Td [(Ann )0.5(Surg)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.01 Tc 0.375 Tw -23.781 -1.25 Td [(2009 A)10(ug;250\(2\):187\22696. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.01 Tw [(10.1097/SL)-35(A.0b013e3181b13ca2)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 19638912.)Tj -0.021 Tw T* (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Co)14(x)]TJ /Span<>> BDC ( )Tj EMC [(JD, S)15(te)-12(tz)]TJ /Span<>> BDC ( )Tj EMC 5.274 0 Td [(J, P)40(ajak)]TJ /Span<>> BDC ( )Tj EMC [(TF. )0.5(T)45(o)14(xic)-24(i)-24(t)-10(y )0.5(cr)-37(i)-24(ter)-36.9(ia of)]TJ /Span<>> BDC ( )Tj EMC 12.227 0 Td [(t)-13(he )0.5(R)-10(adia)15(t)-32(ion )0.5(T)47(her)-33(apy )]TJ 0.039 Tw -18.797 -1.25 Td [(Oncol)30(o)-16(g)16(y G)20(r)-32(oup \(R)-12(T)20(OG\) and t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Eur)-31.9(opean Or)-32(ganiza)15(t)-32(ion for R)13(esear)-32(ch )]TJ 0.053 Tw T* [(and T)50(r)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(Cancer \(EOR)-11.9(T)35(C\). )]TJ /T1_4 1 Tf [(Int J R)20(adiat Oncol Biol Ph)12(ys.)]TJ /T1_1 1 Tf ( 1995 )Tj 0.229 Tw 29.055 36.25 Td [(Mar 30;31\(5\):1341\2266. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/0360-3016\(95\)00060-C)Tj 0 0 0 1 k /GS1 gs 0.229 Tw ( PMID: )Tj 0 Tw T* (7713792.)Tj 0.295 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(r)-24(ei)-23.9(tes-Mar)-22(t)-32(inez)]TJ /Span<>> BDC ( )Tj EMC [(A, Sant)15(ana)]TJ /Span<>> BDC ( )Tj EMC [(N, Ar)-36.9(ias-Sant)-32(ia)-17(go)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. Using )Tj 0.296 Tw -1.296 -1.25 Td [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Common T)40(er)-16(minol)30(o)-16(g)16(y Cr)-37(i)-24(ter)-36.9(ia for A)15.1(d)-17.1(ver)-9.9(se Events \(CT)35(C)20(AE)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj -0.002 Tw T* [(V)30(er)-10(sion 5.0\) t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Ev)-15(al)35(ua)15(te t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Sever)-36.9(i)-24(t)-10(y of)]TJ /Span<>> BDC ( )Tj EMC [(A)15(d)-17(ver)-9.9(se Events of)]TJ /Span<>> BDC ( )Tj EMC [(Ant)-31.9(icancer )]TJ 0 Tw T* [(T)47(her)-33(apies. )]TJ /T1_4 1 Tf 0.169 Tw 4.546 0 Td [(Actas Der)-14(mosif)-42.9(iliog)14(r \(Eng)13(l Ed\).)]TJ /T1_1 1 Tf ( 2021 Jan;112\(1\):90\22692. )Tj 0.137 Tw -4.546 -1.25 Td [(Engl)-31(ish, Sp)32(anish. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.ad.2019.05.009)Tj 0 0 0 1 k /GS1 gs 0.137 Tw ( Epub 2020 Sep 3. )Tj 0.023 Tw T* (PMID: 32891586.)Tj 0.01 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(F)10(or)-24(r)-23.9(est)]TJ /Span<>> BDC ( )Tj EMC 3.044 0 Td [(J)15(A, )0.5(F)-19(inl)-16(a)15(y)-12.9(son)]TJ /Span<>> BDC ( )Tj EMC [(ND, )0.5(S)-16(hear)-15.9(man)]TJ /Span<>> BDC ( )Tj EMC 11.269 0 Td [(DJ. )0.5(End)-16(oscopy )0.5(in )0.5(gastr)-32(ointes)]TJ 0 Tw (-)Tj 0.121 Tw -15.609 -1.25 Td [(t)-32(inal bleeding. )]TJ /T1_4 1 Tf 0 Tw (Lancet)Tj /T1_1 1 Tf 0.121 Tw [(. 1974 A)10(ug 17;2\(7877\):394\2267. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/)Tj T* (s0140-6736\(74\)91770-x)Tj 0 0 0 1 k /GS1 gs 0.023 Tw ( PMID: 4136718.)Tj 0.027 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, P)30(er)-23.9(ez)]TJ /Span<>> BDC ( )Tj EMC [(RO, Nad)42(al)-30.9(in)]TJ /Span<>> BDC ( )Tj EMC [(W, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15.1(t)-32(i)-16(ve ver)-10(sus nonop)]TJ 0 Tw (-)Tj 0.015 Tw -1.296 -1.25 Td [(er)-33(a)15(t)-31.9(i)-16(ve tr)-24(ea)15(tment for st)15(a)-17(ge 0 dist)15(al r)-24(ec)-15.9(t)15(al cancer foll)30(o)-14(wing chemor)-32.9(a)]TJ 0 Tw (-)Tj 0.058 Tw T* [(dia)15(t)-32(ion t)-13(her)-32.9(apy: l)30(ong-ter)-16(m r)-24(esul)56.1(ts. )]TJ /T1_4 1 Tf (Ann Surg.)Tj /T1_1 1 Tf [( 2004 O)-16(c)-15.9(t;240\(4\):711\226)]TJ 0.009 Tc 0.349 Tw T* [(7; discussion 717-8. d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.009 Tw [(10.1097/01.sl)-15.6(a.0000141194.27992.32)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td (PMID: 15383798; PMCID: PMC1356472.)Tj 0.318 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Jin)Tj /Span<>> BDC ( )Tj EMC [(J, T)40(ang)]TJ /Span<>> BDC ( )Tj EMC (Y, Hu)Tj /Span<>> BDC ( )Tj EMC [(C, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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-0.016 Tw 0 -1.218 TD (\030\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\021\007\036\035\034\027\024 \f\021\024\017\021 \r\t\007\ \036\035\017\021\034 \024\f\035\024\032\027\036\027\017\016 III )Tj 0 Tw T* (\f\021\036\023\036\027\017.)Tj 0.319 Tw T* (\200 \020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\n \023\026\006\017\036\027\021\026\n \023\024\021\030\036\ \002\024\r\026\035\024\f\034 \023\024\r)Tj 0 Tw (-)Tj 0.286 Tw T* [(\021\024\030\027\024\036 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\036 )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\024. )0.6(\210\f\035\024\032\027\036\027\017\036 )]TJ 0.251 Tw T* (III\202)Tj /Span<>> BDC ( )Tj EMC 2.16 0 Td [(\227 \032\036\035\031\007\024\004\027\024\036 \022\030\024\r\024\021\036\ \004\036\027\017\036 )0.5(\(F)10(or)-24(r)-23.9(est 1B\) [8] )]TJ -0.074 Tw -2.16 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\030\024\005 \220\030\024\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \021\036\035\026 \032\036\035\031\007\022\026\ \(\026\030\036\020\017\f\021\030\017)Tj 0 Tw (-)Tj 0.067 Tw T* (\030\024\r\026\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \f\031\021\022\017 \023\024\f\035\036 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \r\n\036\001\026\021\036\035\034)Tj 0 Tw (-)Tj 0.148 Tw T* (\f\021\r\026\))Tj /Span<>> BDC ( )Tj EMC 2.504 0 Td [(\227 )0.5(\022\031\023\017\030\024\r\026\027\024 )0.5(\023\031\021\036\n )0.6(\031\f\021\026\027\024\r\022\017 )0.5(\220\027\007\024\f\022\024\023\017\004\036)]TJ 0 Tw (-)Tj 0.045 Tw -2.504 -1.218 Td (\f\022\024\005 \022\035\017\023\f\t. \210\f\035\024\032\027\036\027\017\036\ IIIB)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )Tj 0.131 Tw T* (\022\024\035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\ \f\021\024\n\024\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (6-\036 \f\031\021\022\017 \023\024\f\035\036 \035\026)Tj 0 Tw (-)Tj 0.75 Tw T* (\023\026\030\024\f\022\024\023\017\004\036\f\022\017-\026\f\f\017\f\021\017\ \030\031\036\n\024\005 \027\017\022\024\005 \023\036\030\036\007\027\036\ \005 )Tj 0.129 Tw 0 -1.218 TD (\030\036\036\022\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017\ , \017\035\036\024\f\021\024\n\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\221\024\030\027\002\024\035\035\031. )Tj 0.012 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\021\024\030\027\024\n \b\017\030\031\030\020\017\004\036\f\022\ \024\n )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\036 \023\024\021\030\036)]TJ 0 Tw (-)Tj 0 -1.218 TD (\002\024\r\026\035\024\f\034 \030\026\024\002\013\036\027\017\036 \022\024\ \035\024\030\036\022\021\026\035\034\027\024\020\024 \026\027\026\f\021\024\ \n\024\026.)Tj -0.011 Tw T* (\200 \020\030\031\023\023\036 \207 \024\f\035\024\032\027\036\027\017\036\ IIIB \023\024)Tj /Span<>> BDC ( )Tj EMC [(Cl)-15.9(av)-16(ien\226Dind)-16(o \026\030\036\020\017)]TJ 0 Tw (-)Tj 0.059 Tw T* [(\f\021\030\017\030\024\r\026\027\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 5.815 0 Td [(\024\007\027\024\020\024 )0.5(\023\026\006\017\036\027\021\026)]TJ /Span<>> BDC ( )Tj EMC 7.27 0 Td [(\227 )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )]TJ -0.009 Tw -13.085 -1.218 Td (\022\024\035\024\026\027\026\035\034\027\024\020\024 \026\027\026\f\021\024\ \n\024\026 \023\024\f\035\036 \035\026\023\026\030\024\f\022\024\023\017\ \004\036\f\022\024\005 )Tj 0.052 Tw T* (\002\030\033\001\027\024-\026\027\026\035\034\027\024\005 \030\036\036\022\ \006\017\017 \023\030\016\n\024\005 \022\017\001\022\017, \017\035\036\024\ \f\021\024)Tj 0 Tw (-)Tj 0.177 Tw T* (\n\017\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\221\024\030\027\002\024\035\035\031. \215\026\006\017\036\027\021\031 \r\ \t\023\024\035\027\036\027\024 \023\024\r\021\024\030\027\024\036 )Tj 0.076 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \030\036\035\026\023\026\030\024\021\024)Tj 0 Tw (-)Tj 0.061 Tw T* (\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\024\002\013\036\027\017\016 \022\024\035\024\026\027\026\035\034\ \027\024\020\024 \026\027\026\f\021\024\n\024\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (8-\036 )Tj 0 Tw T* (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 420.3798 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.02 Tw 10 0 0 10 70.8661 396.0238 Tm (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\036\r \220\235\235\036\022\021\017\r\027\024\ \f\021\017 \027\036\024\026\007\255\033\r\026\027\021\027\024\005 )Tj 0.31 Tw T* [(\021\036\030\026\023\017\017 \016\r\035\016\036\021\f\016 )0.5(\f\021\036\023\036\027\034 \035\036\004\036\002\027\024\020\024 \023\026\ \021\024\n\024\030\235\024\026 )]TJ 0.071 Tw T* (\024\023\031\b\024\035\017, \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036, \017)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \023\024\035\027\t\b \022\035\017\027\017\004\ \036\f\022\017\b )Tj 0.148 Tw T* (\024\021\r\036\021\024\r \024\023\031\b\024\035\017. \221\026\022, \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\026\n \017\f\f\035\036\007\024\r\026\027\ \017\016 )Tj 0.056 Tw T* (Habr-Gama \202., \023\024\f\035\036 \023\030\024\r\036\007\036\027\017\016\ \023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\024 )Tj 0.02 Tw T* (\022\031\030\f\026 \027\036\024\026\007\255\033\r\026\027\021\027\024\005\ \216\214\221, 10-\035\036\021\027\016\016 \r\t\032\017\r\026\036\n\024\f\ \021\034 )Tj 0.122 Tw T* [(\007\024\f\021\017\020\035\026 )0.5(97,7%, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC 7.793 0 Td (\002\036\030\036\006\017\007\017\r\027\026\016)Tj /Span<>> BDC ( )Tj EMC 6.682 0 Td [(\227 )0.5(84%. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.739 0 Td (\220\021\024\n )Tj 0.609 Tw -20.215 -1.218 Td (\004\026\f\021\024\021\026 \023\024\035\027\t\b \022\035\017\027\017\004\ \036\f\022\017\b \024\021\r\036\021\024\r \f\024\f\021\026\r\017\035\026\ )Tj 0 Tw T* (26,8% [9].)Tj 0.469 Tw T* [(\200 )0.5(\n\031\035\034\021\017\006\036\027\021\030\024\r\024\n )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n )0.6(\017\f\f\035\036\007\024)]TJ 0 Tw (-)Tj 0.383 Tw T* [(\r\026\027\017\017 S)-21(TELL)-34.9(AR \024\021\030\026\032\036\027\t \030\036\031\035\034\021\026\021\t \023\ \030\017\n\036\027\036\027\017\016 )]TJ 0.302 Tw T* [(\021\024\021\026\035\034\027\024\005 )0.6(\027\036\024\026\007\255\033\r\026\027\021\027\024\005 )0.6(\021\036\030\026\023\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 17.08 0 Td [(\030\036\032\017\n\036 )0.5(\022\024)]TJ 0 Tw (-)Tj 0.336 Tw -17.08 -1.218 Td [(\030\024\021\022\024\020\024 \022\031\030\f\026 )0.5(\022\030\031\023\027\024\235\030\026\022\006\017\024\027\027\024\005 \214\ \221 )0.5(\222\210\212 25 )0.5(\206\030 )]TJ 0.06 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ \021\036\030\026\023\017\036\005: \004\026\f\021\024\021\026 \023\024\035\ \027\t\b )Tj 0.115 Tw T* (\022\035\017\027\017\004\036\f\022\017\b \024\021\r\036\021\024\r \f\024\ \f\021\026\r\017\035\026 11,1% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221, )Tj 0.273 Tw T* (\021\024\020\007\026 \022\026\022 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \023\030\024\035\024\027\020\017\030\ \024\r\026\027\027\024\005 \216\214\221 )Tj 0 Tw T* (\222\210\212 50)Tj /Span<>> BDC ( )Tj EMC (\206\030)Tj /Span<>> BDC ( )Tj EMC (\227 4,4% [10].)Tj 0.132 Tw T* (\222 \006\036\035\034\033 \024\006\036\027\022\017 \024\021\r\036\021\026\ \024\023\031\b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\036 )Tj 0.173 Tw T* (\035\036\004\036\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \023\024\035\027\024\020\024 \022\035\017\ \027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026 )Tj 0.006 Tw T* (\(cCR\) \024\023\031\b\024\035\017 \023\030\017\n\036\027\016\033\021: \023\ \026\035\034\006\036\r\024\036 \017)Tj /Span<>> BDC ( )Tj EMC (\220\027\007\024\f\022\024\023\017\004\036)Tj 0 Tw (-)Tj -0.104 Tw T* (\f\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \n\026\020\027\017\021\027\024-\030\036\024\027\026\ \027\f\027\024\005 \021\024)Tj 0 Tw (-)Tj -0.005 Tw T* (\n\024\020\030\026\235\017\017 \(\204\217\221\) \024\030\020\026\027\024\ \r \n\026\035\024\020\024 \021\026\026. \222\024\004\036\021\026\027\017\ \036 \220\021\017\b )Tj 0.104 Tw T* (\021\030\036\b \n\036\021\024\007\024\r \017\f\f\035\036\007\024\r\026\027\ \017\016 \023\024\r\024\035\016\036\021 \f\023\030\024\020\027\024\017\ \030\024)Tj 0 Tw (-)Tj 0.172 Tw T* (\r\026\021\034 \024\021\f\031\021\f\021\r\017\036 \024\f\021\026\021\024\ \004\027\024\005 \024\023\031\b\024\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (98% \f\035\031\004\026\036\r )Tj 0.076 Tw T* ([11]. \221\026\022, \024\030\017\036\027\021\017\030\024\n \007\035\016 \ \023\024\f\021\026\027\024\r\022\017 cCR \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\035\034)Tj 0 Tw (-)Tj 0.307 Tw T* (\006\036\r\024\n \030\036\022\021\026\035\034\027\024\n \017\f\f\035\036\ \007\024\r\026\027\017\017 \016\r\035\016\036\021\f\016 \020\035\026\007\ \022\026\016 )Tj 0.464 Tw T* (\f\035\017\017\f\021\026\016 \024\002\024\035\024\004\022\026 \023\030\016\ \n\024\005 \022\017\001\022\017 \017\035\017 \027\026\035\017\004\017\036\ )Tj -0.01 Tw 23.244 64.543 Td (\n\016\020\022\024\020\024, \220\035\026\f\021\017\004\027\024\020\024 \030\ \031\002\006\026. \233\027\007\024\f\022\024\023\017\004\036\f\022\017\n\ \022\030\017\021\036)Tj 0 Tw (-)Tj 0.029 Tw T* (\030\017\036\n \023\024\035\027\024\020\024 \022\035\017\027\017\004\036\ \f\022\024\020\024 \024\021\r\036\021\026 \024\023\031\b\024\035\017 \016\ \r\035\016\036\021\f\016 )Tj 0.207 Tw T* (\023\035\024\f\022\017\005, \002\036\035\036\f\024\r\026\021\t\005 \030\031\ \002\036\006 \002\036 \017\255\016\r\035\036\027\017\016, \r\024)Tj 0 Tw (-)Tj 0.224 Tw T* [(\n\024\032\027\024 )0.5(\027\026\035\017\004\017\036 )0.6(\021\036\035\036\026\027\020\017\024\220\022\021\026\017\005 )0.6([12]. )0.5(\215\024)]TJ /Span<>> BDC ( )Tj EMC 18.943 0 Td (\007\026\027\027\t\n )Tj 0.095 Tw -18.943 -1.218 Td (\204\217\221 \023\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\ \005 \024\021\r\036\021 \b\026\030\026\022\021\036\030\017\031\036\021\f\ \016 \027\026)Tj 0 Tw (-)Tj 0.016 Tw T* (\035\017\004\017\036\n \030\031\002\006\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \030\026\027\036\036 \030\026\f\023\024\035\026\ \020\026\r\001\036\005\f\016 \024\023\031)Tj 0 Tw (-)Tj 0.104 Tw 0 -1.218 TD (\b\024\035\017, \027\036 \024\020\030\026\027\017\004\017\r\026\033\013\017\ \n \007\017\235\235\031\017\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\2212, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.246 Tw 0 -1.218 TD (\024\021\f\031\021\f\021\r\017\036\n \r\017\031\026\035\034\027\024 \017\ \n\036\027\036\027\027\t\b \035\017\n\235\026\021\017\004\036\f\022\017\ \b )Tj 0 Tw T* (\031\035\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\024\030\036\022\021\026\035\034\027\024\005 \022\035\036\021\004\ \026\021\022\036 [13].)Tj 0.213 Tw T* (\200 \023\030\024\r\036\007\036\027\027\024\n \027\026\n\017 \030\026\027\ \007\024\n\017\017\030\024\r\026\027\027\024\n \017\f\f\035\036\007\024\ )Tj 0 Tw (-)Tj 0.149 Tw T* [(\r\026\027\017\017, )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\017 )0.5(\221\203\221 \f)]TJ /Span<>> BDC ( )Tj EMC 12.469 0 Td [(\023\030\017\n\036\027\036\027\017\036\n )0.5(\022\024\030\024\021\022\024)]TJ 0 Tw (-)Tj 0.287 Tw -12.469 -1.218 Td (\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\024 \022\031\ \030\f\024\r \214\221, \f\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.046 Tw T* (\027\026\004\017\n\t\b \030\026\035\017\004\017\005 \022\026\022 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \004\026\f\021\024\021\t \023\024\035\027\t\b \ )Tj 0.053 Tw T* [(\022\035\017\027\017\004\036\f\022\017\b, )0.6(\021\026\022 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.143 0 Td [(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.6(\024\021\r\036\021\024\r )0.5(\027\036 )]TJ 0.148 Tw -8.143 -1.218 Td (\023\024\035\031\004\036\027\024)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\ \035\034\021\026\021\t \035\036\004\036\027\017\016 )Tj 0 Tw T* (\f\024\023\024\f\021\026\r\017\n\t \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b.)Tj 0.211 Tw T* (\221\024\021\026\035\034\027\026\016 \027\036\024\026\007\255\033\r\026\027\ \021\027\026\016 \021\036\030\026\023\017\016 \024\021\022\030\t\r\026\036\ \021 \r\024)Tj 0 Tw (-)Tj -0.009 Tw T* (\n\024\032\027\024\f\021\017 \007\035\016 \007\017\027\026\n\017\004\036\ \f\022\024\020\024 \027\026\002\035\033\007\036\027\017\016 \023\026\006\ \017\036\027\021\024\r )Tj 0.056 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\027\t\n )0.5(\022\035\017\027\017\004\036\f\022\017\n )0.5(\024\021\r\036\021\024\n \017)]TJ /Span<>> BDC ( )Tj EMC [(\r )0.5(\030\016\007\036 )0.5(\f\035\031\004\026\036\r \023\024)]TJ 0 Tw (-)Tj 0.18 Tw T* [(\r\024\035\016\036\021 \017\002\036\032\026\021\034 \b\017\030\031\030\ \020\017\004\036\f\022\024\020\024 )0.5(\035\036\004\036\027\017\016, \023\030\017\007\036\030)]TJ 0 Tw (-)Tj 0.096 Tw T* (\032\017\r\026\016\f\034 \f\021\030\026\021\036\020\017\017 \027\026\002\ \035\033\007\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\027\017\016 [14,15]. )Tj 0.015 Tw T* (\222\035\036\007\031\036\021 \026\n\036\021\017\021\034, \004\021\024 \007\ \026\027\027\026\016 \f\021\030\026\021\036\020\017\016 \016\r\035\016\036\ \021\f\016 \220\022\f)Tj 0 Tw (-)Tj 0.114 Tw T* [(\023\036\030\017\n\036\027\021\026\035\034\027\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 8.035 0 Td [(\023\030\017\n\036\027\017\n\026 )0.6(\021\024\035\034\022\024 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 8.891 0 Td (\f\023\036\006\017\026\035\017\017)Tj 0 Tw (-)Tj 0.228 Tw -16.926 -1.218 Td [(\030\024\r\026\027\027\t\b \n\036\007\017\006\017\027\f\022\017\b )0.5(\031\004\030\036\032\007\036\027\017\016\b, \026)]TJ /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\024\n )Tj 0.07 Tw T* [(\035\036\004\036\027\017\016 )0.6(\030\026\022\026 )0.5(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\024\f\021\026\036\021\f\016 )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\036 )]TJ 0.168 Tw T* [(\035\036\004\036\027\017\036, )0.6(\026\004\026\f\021\031\033 )0.5(\f\024\023\030\024\r\024\032\007\026\033\013\036\036\f\016 )0.6(\027\036\024\002\b\024\007\017\n\024)]TJ 0 Tw (-)Tj T* (\f\021\034\033 \235\024\030\n\017\030\024\r\026\027\017\016 \022\017\001\ \036\004\027\024\005 \f\021\024\n\t.)Tj 0.416 Tw T* (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016, \026\022\021\031\ \026\035\034\027\t\n \024\f\021\026\036\021\f\016 \r\024\023\030\024\f )Tj 0.337 Tw T* (\024\023\030\036\007\036\035\036\027\017\016 \022\026\021\036\020\024\030\ \017\017 \023\026\006\017\036\027\021\024\r, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\024)Tj 0 Tw (-)Tj 0.185 Tw T* (\f\035\036 \023\030\024\r\036\007\036\027\017\016 \221\203\221 \f\035\036\ \007\031\036\021 \024\032\017\007\026\021\034 \023\024\035\027\024\020\024\ \022\035\017)Tj 0 Tw (-)Tj 0.242 Tw T* (\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n Guid)42.1(a A.M. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., )Tj 0.441 Tw T* (\027\026\017\002\024\035\036\036 \r\026\032\027\t\n\017 \023\030\024\020\ \027\024\f\021\017\004\036\f\022\017\n\017 \235\026\022\021\024\030\026\n\ \017, )Tj 0.507 Tw T* (\017\f\023\024\035\034\031\033\013\017\n\017\f\016 \007\035\016 \024\006\ \036\027\022\017 \023\030\024\020\027\024\026 \023\024\035\027\024\020\024\ )Tj 0.449 Tw T* [(\030\036\020\030\036\f\f\026 \024\023\031\b\024\035\017, \016\r\035\016\033\ \021\f\016: )0.5(\022\035\017\027\017\004\036\f\022\026\016 \f\021\026\007\017\016 )]TJ 0.055 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 TNM, \220\022\f\021\030\ \026\n\031\030\026\035\034\027\026\016 \f\024\f\031\007\017\f\021\026\016\ )Tj 0.127 Tw T* (\017\027\r\026\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024\021\036\027\006\017\026\035\034\027\024\036\ \r\024\r\035\036\004\036\027\017\036 \006\017\030\022\031)Tj 0 Tw (-)Tj 0.201 Tw T* [(\035\016\030\027\024\020\024 )0.5(\022\030\026\016 \030\036\036\022\006\017\017 )0.5([16]. \222\035\036\007\031\036\021 )0.5(\026\n\036\021\017\021\034, )0.5(\004\021\024 )]TJ 0.196 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\017\b \022\030\031\023\027\t\b \030\026\027\007\024\n\017\017\ \030\024\r\026\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017)Tj 0 Tw (-)Tj 0.107 Tw T* [(\016\b, \022\026\022 RAPIDO [4], P)10(ol)-31(ishII [17], K)20(CSGC)13(O 14-03 [18], )]TJ 0.05 Tw T* [(W)31(AIT [19], PRODIGE-23 [20], \f\021\026\021\017\f\021\017\004\036\f\022\017\ \027\026\004\017\n\t\b )]TJ 0.431 Tw T* (\030\026\035\017\004\017\005 \024\021\027\024\f\017\021\036\035\034\027\ \024 \022\035\017\027\017\004\036\f\022\024\005 \f\021\026\007\017\017 \024\ \023\031)Tj 0 Tw (-)Tj 0.108 Tw T* (\b\024\035\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\t\n \024\021\r\036\021\024\n, \027\036 \002\t\035\024 )Tj 0.405 Tw T* (\023\024\035\031\004\036\027\024. \203\026\035\017\004\017\036 \017\027\r\ \026\017\017 \220\022\f\021\030\026\n\031\030\026\035\034\027\t\b \f\024\ )Tj 0 Tw (-)Tj 0.164 Tw T* (\f\031\007\024\r \024\006\036\027\017\r\026\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017 RAPIDO, \024\007\027\026\022\024\ )Tj 0.066 Tw T* (\036\201 \f\r\016\034 \f)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\024\n \024\023\031\b\024\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\221\203\221 \027\036 \002\t\035\026 \017\031\004\036\027\026. )Tj -0.029 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\017\036 \023\024\035\031\004\036\027\027\t\b \027\026\n\ \017 \007\026\027\027\t\b, \f\030\036\007\017 \023\030\036\007\017\022)Tj 0 Tw (-)Tj 0.03 Tw T* (\021\024\030\024\r \023\024\035\027\024\020\024 \024\021\r\036\021\026 \024\ \023\031\b\024\035\017 \r\t\016\r\035\036\027\t \020\035\031\002\017\027\ \026 \017\027)Tj 0 Tw (-)Tj -0.034 Tw T* (\r\026\017\017 \023\036\030\r\017\004\027\024\005 \024\023\031\b\024\035\ \017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\021\026\021\031\f \035\017\n\235\024\031\035\024\ \r )Tj 0 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016.)Tj 0.486 Tw T* (\230\f\f\035\036\007\031\036\n\t\036 \030\036\032\017\n\t \021\024\021\026\ \035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\027\024\005\ )Tj 0.069 Tw T* (\021\036\030\026\023\017\017 \f\024\023\024\f\021\026\r\017\n\t \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \027\036\023\024\f\030\036\007\f\021\r\036\027\027\ \t\b )Tj 0.232 Tw T* [(\030\036\031\035\034\021\026\021\024\r \035\036\004\036\027\017\016. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\004\036\n, \022\026\022 \022\024\030\024\021\022\017\005 )Tj 0.019 Tw T* (\022\031\030\f \214\221, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\026\016 \216\214\221\ \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031)Tj 0 Tw (-)Tj -0.023 Tw T* [(\033\013\036\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\036\005 )0.6(\n\024\020\031\021 )0.5(\023\030\017\n\036\027\016\021\034\f\016 )0.6(\007\035\016 )0.5(\035\036\004\036\027\017\016 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7653 56.0378 Tm (122)Tj ET endstream endobj 777 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-10(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ \026)11(\004\005\017\224\n\n \b\022\020\004\225\004\t\n\n \005\017\r\017 )]TJ 0 -1 TD [(\224\005\213\024\025\221 \r\n\204\r\n: \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 42.014 1 Td [(Ef)-31(f)-21(icacy of\022total neoadju)10(v)10(ant th)11(er)21.1(apy for r)31(ectal )]TJ 4.252 -1 Td [(cancer: r)31.1(esults of\022a\022r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.065 Tw 10 0 0 10 42.5197 432.5579 Tm (\(26,5%\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\035\024\027\020\017\030\024\r\026\027\ \027\024\005 \216\214\221 \()Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf 0.065 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\) )Tj 0 Tw 0 -1.218 TD (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.234 Tw T* (\222\024\023\024\f\021\026\r\017\n\t \024\022\026\026\035\017\f\034 \030\ \036\031\035\034\021\026\021\t \b\017\030\031\030\020\017\004\036\f\022\ \024\020\024 )Tj 0.068 Tw T* (\035\036\004\036\027\017\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \024\021\030\017\006\026\021\036\035\034\027\t\ \b \020\030\026\027\017\006 \030\036\036\022\006\017\017, )Tj -0.029 Tw T* (\022\026\004\036\f\021\r\031 \n\036\024\030\036\022\021\031\n\220\022\021\ \024\n\017\017, \f\021\036\023\036\027\017 \024\021\r\036\021\026 \024\023\ \031\b\024\035\017 )Tj 0.216 Tw 23.244 4.871 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\027\036\024\026\007\255\033\r\026\027\021\027\024\036 )0.5(\035\036\004\036\027\017\036 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\n )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\016\n \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.238 Tw T* (\200 \f\021\030\031\022\021\031\030\036 \024\f\035\024\032\027\036\027\017\ \005 \f\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\ \024 \024\f)Tj 0 Tw (-)Tj 0.621 Tw T* (\035\024\032\027\036\027\017\016 I-II \f\021\036\023\036\027\017 \023\024\ )Tj /Span<>> BDC ( )Tj EMC [(Cl)-16(av)-16(ien\226Dind)-16(o \002\t\035\017 )]TJ 1.543 Tw T* (\023\030\036\007\f\021\026\r\035\036\027\t \023\026\030\036\024\n \032\036\ \035\031\007\024\004\027\024-\022\017\001\036\004\027\024\020\024 )Tj ET q 42.52 122.57 368.504 243.183 re W n q /GS0 gs 368.5039142 0 0 243.1885765 42.5196833 122.5642987 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.029 Tw 9 0 0 9 42.5197 111.7701 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( )0.5(\202\032\022\021\013\027 )0.6(\202\020\033\f\020\025\020-\215\020\235\027\032\020 )0.6(\033\031)]TJ /Span<>> BDC ( )Tj EMC 16.641 0 Td [(\023\032\027\200\f\027\023\025\027\235 )0.6(\240\027\016\032\027\006\022\030\022\021\025\031\235 )0.7(\021\013\255\022\021\020\027\026\031\024\023\022 )0.6(\033\031)]TJ /Span<>> BDC ( )Tj EMC 19.696 0 Td [(\b\032\r\033\033\020\026 )0.6(\n\031\032\031\023\n\031\b\031 )0.5(\n\r\032\024\020 )0.6(\f\r\007\027\021\031\235 )]TJ 0 Tw -36.338 -1.2 Td (\023\027\032\020\033\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\f\031\025\b\022\032\031\021\020\025\025\031\235 \225\035)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.068 Tw 0 -1.2 TD [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( K)17(aplan-Mayer cur)-41.9(v)12.9(es for three-year disease-free sur)-42(viv)16(al among g)14(roups with shor)-40(t-course radiation therap)12(y and long-)]TJ 0 Tw T* [(course chemoradio)13.2(therap)12(y)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \232\020\024\023\031\023\020 \033\031\f\025\013\200 \031\023\021\027\023\ \031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.323 0 Td [( R)5.7(a)-9.2(t)-1.5(e o)4(f c)2.8(o)-4(m)-1(p)-4.9(le)-8.6(t)-1.6(e r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)3.7(s)0.5(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.1809 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 224.187 715.1809 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 715.1809 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 715.1809 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3617 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1117 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 694.1117 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 694.1117 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 694.1117 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.9004 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 682.6504 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 682.6504 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 682.6504 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 682.6504 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4391 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 671.1891 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 671.1891 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 671.1891 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 671.1891 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.9778 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.7278 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 42.7697 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 659.7278 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 224.187 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 659.7278 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 659.7278 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 648.5165 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 648.2665 cm 0 0 m 181.667 0 l S Q q 1 0 0 1 224.187 648.2665 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 337.5728 648.2665 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 450.9586 648.2665 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 116.7386 701.7463 Tm (\200\004\006\004\214\r\003\006)Tj 15.8 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 10.861 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_4 1 Tf 11.494 0.6 Td (\t)Tj /T1_1 1 Tf -53.244 -2.033 Td (pCR)Tj 26.729 0 Td (9/53)Tj /Span<>> BDC ( )Tj EMC (\(14,7%\))Tj 14.423 0 Td (6/51)Tj /Span<>> BDC ( )Tj EMC (\(9,3%\))Tj 11.759 0 Td (0,6)Tj -52.911 -1.433 Td (cCR \(\n\036\007\017\026\027\026 \023\030\024\f\035\036\032\036\027\027\024\ \f\021\017, \n\036\f\016\006\036\r: 18)Tj /Span<>> BDC ( )Tj EMC (\(3-35\)\) )Tj 27.701 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,2%\))Tj 13.673 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(17,2%\))Tj 11.287 0 Td (0,18)Tj -52.661 -1.433 Td (\217\036\006\017\007\017\r \023\024\f\035\036 \023\024\035\027\024\020\024\ \022\035\017\027\017\004\036\f\022\024\020\024 \024\021\r\036\021\026)Tj 27.322 0 Td (4/9)Tj /Span<>> BDC ( )Tj EMC (\(44%\))Tj 13.923 0 Td (5/16)Tj /Span<>> BDC ( )Tj EMC (\(31%\))Tj 11.666 0 Td (0,7)Tj -52.911 -1.433 Td (\210\002\013\026\016 \004\026\f\021\024\021\026 \023\024\035\027\t\b \024\ \021\r\036\021\024\r)Tj 27.201 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(22,9%\))Tj 14.173 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(26,5%\))Tj 11.537 0 Td (0,6)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 631.5473 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \200\022\032\r\032\b\022\007\027\024\ \n\031\b\031 \f\027\007\027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0.002 Tc -0.002 Tw 3.329 0 Td [( R)4.8(e)-20(s)8.7(u)0.5(l)7.2(t)-30.9(s)2.1( o)6(f)]TJ /Span<>> BDC 4.088 0 Td ( )Tj EMC [(s)8.7(u)3.6(rg)-16.7(ic)5.2(a)-2.4(l)2( t)-7.6(re)-5.5(a)-7.2(t)-8.6(m)-3.3(e)-5(n)1.4(t)]TJ ET /GS2 gs q 1 0 0 1 42.5197 616.2453 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 201.5098 616.2453 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 269.5413 616.2453 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 360.25 616.2453 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 616.2453 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 595.4261 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 595.1761 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 583.7148 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 595.1761 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 595.1761 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 595.1761 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 595.1761 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 583.9648 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.7148 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 572.5035 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 583.7148 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 583.7148 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 583.7148 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 572.5035 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 572.5035 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 572.2535 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 560.7922 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 572.2535 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 572.2535 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 572.2535 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 572.2535 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 561.0422 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 560.7922 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 549.3309 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 560.7922 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 560.7922 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 560.7922 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 549.5809 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 549.3309 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 538.1197 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 549.3309 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 549.3309 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 549.3309 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 538.1197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 538.1197 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 537.8697 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 526.4084 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 537.8697 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 537.8697 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 537.8697 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 537.8697 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 526.6584 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 526.4084 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 514.9471 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 526.4084 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 526.4084 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 526.4084 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 515.1971 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 514.9471 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 503.4858 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 514.9471 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 514.9471 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 514.9471 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 503.7358 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 503.4858 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 492.2745 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 503.4858 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 503.4858 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 503.4858 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 492.2745 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 492.2745 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 492.0245 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 42.7697 480.5632 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.5098 492.0245 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 201.5098 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 492.0245 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 492.0245 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 492.0245 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 480.8132 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 480.5632 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 469.102 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 201.2598 480.5632 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 480.5632 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 480.5632 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 469.352 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 469.102 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 457.8907 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 201.2598 469.102 cm 0 0 m 68.281 0 l S Q q 1 0 0 1 201.5098 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 469.102 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 269.5413 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 469.102 cm 0 0 m 90.959 0 l S Q q 1 0 0 1 360.25 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 457.8907 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 457.8907 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 457.6407 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 201.5098 457.6407 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 269.5413 457.6407 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 360.25 457.6407 cm 0 0 m 90.709 0 l S Q q 1 0 0 1 450.9586 457.6407 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 139.4158 602.8107 Tm (\200\004\006\004\214\r\003\006)Tj 17.217 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (54\))Tj 8.027 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (51\))Tj /T1_4 1 Tf 10.076 0.6 Td (\t)Tj /T1_1 1 Tf -53.244 -2.033 Td (\206\030\026\027\017\006\t \030\036\036\022\006\017\017)Tj 23.227 0 Td (R0)Tj 8.569 0 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(91%\))Tj 11.339 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(92%\))Tj 9.777 0 Td (1,0)Tj -29.685 -1.433 Td (R1)Tj 9.069 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 11.339 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj -43.634 -1.433 Td (\025\026\004\036\f\021\r\024 \n\036\024\030\036\022\021\031\n\220\022\021\ \024\n\017\017)Tj 22.083 0 Td (Quirke 1)Tj 9.713 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(19%\))Tj 11.589 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.527 0 Td (0,5)Tj -30.829 -1.433 Td (Quirke 2)Tj 9.963 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(15%\))Tj 11.339 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj -21.301 -1.433 Td (Quirke 3)Tj 9.713 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(66%\))Tj 11.339 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(76%\))Tj -43.134 -1.433 Td (\222\021\036\023\036\027\034 \024\021\r\036\021\026 \024\023\031\b\024\035\ \017 \023\024)Tj /Span<>> BDC ( )Tj EMC (Ryan)Tj 23.49 0 Td (0)Tj 8.555 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(17%\))Tj 11.339 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.527 0 Td (0,6)Tj -29.421 -1.433 Td (1)Tj 8.555 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(15%\))Tj 11.089 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(25%\))Tj -19.644 -1.433 Td (2)Tj 8.305 0 Td (24)Tj /Span<>> BDC ( )Tj EMC (\(47%\))Tj 11.339 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(47%\))Tj -19.644 -1.433 Td (3)Tj 8.305 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(21%\))Tj 11.589 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj -43.384 -1.433 Td 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\r\t\016\r\035\036\027\026 \031)]TJ /Span<>> BDC ( )Tj EMC (2% \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \207 \(\216\214\221\), )Tj -0.037 Tw 0 -1.218 TD (\021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\(\214\221\))Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (9% \023\026\006\017\036\027\021\024\r \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.193 Tw 0 -1.218 TD (\222\030\036\007\017 125 \023\026\006\017\036\027\021\024\r, \r\022\035\033\ \004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036, )Tj 0.009 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (25 \(20%\) \002\t\035 \007\017\026\020\027\024\f\021\017\030\024\r\026\027\ \023\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\005 )Tj 0.211 Tw 0 -1.218 TD [(\024\021\r\036\021. )0.5(\230)]TJ /Span<>> BDC ( )Tj EMC 4.437 0 Td [(\027\017\b )0.5(9/61 )0.5(\(15%\) )0.6(\023\026\006\017\036\027\021\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.928 0 Td [(\020\030\031\023\023\036 )0.5(\202)]TJ /Span<>> BDC ( )Tj EMC 4.227 0 Td (\017 )Tj 0 Tw -21.592 -1.218 Td (16/64 \(25%\) \023\026\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.064 Tw 0 -1.218 TD (\215\030\017 \023\030\024\f\035\036\032\036\027\027\024\f\021\017 \024\021\ 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (35 \n\036\f\016\006\036\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 )Tj 0.177 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (18 \n\036\f\016\006\036\r, \004\026\f\021\024\021\026 \023\024\035\027\t\ \b \022\035\017\027\017\004\036\f\022\017\b \024\021\r\036\021\024\r )Tj 0.131 Tw 0 -1.218 TD (\f\024\f\021\026\r\017\035\026 5/61 \(8,2%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 \022\031\030\ \f\026 \214\221 )Tj 0.321 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (11/64 \(17,2%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\035\024\027\020\017\030\024\r\026\027\ \027\024\005 \216\214\221 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf 0.041 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\). \211)Tj /Span<>> BDC ( )Tj EMC (9)Tj /Span<>> BDC ( )Tj EMC (\(36%\) \017)Tj /Span<>> BDC ( )Tj EMC (25 \023\026\006\017\036\027\021\024\r, \022\024\021\024\030\t\n \007\017\ \026\020)Tj 0 Tw (-)Tj 0.276 Tw 0 -1.218 TD (\027\024\f\021\017\030\024\r\026\027 cCr \017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\035\024\032\036\027\026 \021\026\022\021\017\022\026 \253\ w)-12(a)15(tch and )]TJ 0.198 Tw 0 -1.218 TD [(w)-12(ai)-24(t\273, \026\030\036\020\017\f\021\030\017\030\024\r\026\027\024 \023\030\ \024\020\030\036\f\f\017\030\024\r\026\027\017\036 \026\002\024\035\036\ )]TJ 0 Tw (-)Tj 0 -1.218 TD (\r\026\027\017\016 \()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7\).)Tj 0.094 Tw 0 -1.218 TD (\200 \020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\030\036\f\f\017\030\024\r\026\027\017\036 \026\002\024\ \035\036\r\026\027\017\016 \007\017\026\020\027\024\f)Tj 0 Tw (-)Tj 0.028 Tw 0 -1.218 TD (\021\017\030\024\r\026\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (4 \f\035\031\004\026\016\b: \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\b \023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\f\021\027\t\005 )Tj 0.175 Tw 0 -1.218 TD (\030\036\006\017\007\017\r, \036\013\036 \031)Tj /Span<>> BDC ( )Tj EMC (\007\r\024\017\b)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\f\021\027\t\005 \030\036\006\017\007\017\r \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\026)Tj 0 Tw (-)Tj 0.189 Tw 0 -1.218 TD (\035\036\027\027\t\036 \n\036\021\026\f\021\026\t. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207 \r\t\016\r\035\036\027\024 5 \f\035\031\004\ \026\036\r )Tj 0.125 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Tw T* (\020\030\036\f\f\017\030\024\r\026\027\017\016 \026\002\024\035\036\r\026\ \027\017\016. \221\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 )Tj 0.088 Tw 0 -1.218 TD (\022\031\030\f\026 \035\031\004\036\r\024\005 \021\036\030\026\023\017\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 10/61 \(16,3%\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 )Tj 0.166 Tw 0 -1.218 TD (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005 \216\214\221\ )Tj /Span<>> BDC ( )Tj EMC (\227 10/64 \(15,6%\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026)Tj 0 Tw (-)Tj 0.127 Tw 0 -1.218 TD [(\035\017\036 12-\n\036\f\016\004\027\024\005 )0.5(\002\036\030\036\006\017\007\017\r\027\024\005 \r\t\032\017\r\026\036\n\ \024\f\021\017)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj 0.15 Tw -21.11 -1.218 Td (\r\036\030\024\016\021\027\024\f\021\034 \024\021\f\031\021\f\021\r\017\016\ \030\036\006\017\007\017\r\026 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026)Tj 0 Tw (-)Tj 0.104 Tw T* (\r\017\035\026 84,8% \(95% \212\230: 74,5\22696,4\), \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \207)Tj /Span<>> BDC ( )Tj EMC (\227 96% )Tj 0.009 Tw 0 -1.218 TD (\(95% \212\230: 90,7\226100\). \204\036\007\017\026\027\026 \007\024\032\ \017\021\017\016 \007\024\f\021\017\020\027\031\021\026 \027\036 )Tj 0.173 Tw 0 -1.218 TD (\002\t\035\026, \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026\004\017\n\024 \027\036 \030\026\035\017\004\026)Tj 0 Tw (-)Tj 0.098 Tw 0 -1.218 TD (\035\017\f\034 \n\036\032\007\031 \f\024\002\024\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\036\030\036\006\017\007\017\r\027\024\005 \r\t\032\017\r\026\036\n\ \024\f\021\017 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,54\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.194 Tw 0 -1.218 TD [(\215\024 )0.5(\f\024\f\021\024\016\027\017\033 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.784 0 Td [(\027\024\016\002\030\034 )0.6(2025 )0.5(\020\024\007\026 )0.5(\023\024\007 )0.5(\007\017\027\026\n\017\004\036)]TJ 0 Tw (-)Tj 0.097 Tw -7.784 -1.218 Td (\f\022\017\n \027\026\002\035\033\007\036\027\017\036\n, \002\036 \023\030\ \017\027\026\022\024\r \r\024\r\030\026\021\026 \026\002\024\035\036)Tj 0 Tw (-)Tj 0.204 Tw 0 -1.218 TD (\r\026\027\017\016 \027\026\b\024\007\017\021\f\016 5/61 \(8,2%\) \023\026\ \006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t )Tj 0.219 Tw 0 -1.218 TD (\202, \017)Tj /Span<>> BDC ( )Tj EMC (11/64 \(17,2%\))Tj /Span<>> BDC ( )Tj EMC (\227 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \207. \210\007\017\027 \023\026\006\017\036\027\021\ )Tj 0.019 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \202, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\020\024 \007\017\026\020\027\024\f\021\017\030\024\ \r\026\027 \023\024\035\027\t\005 \022\035\017)Tj 0 Tw (-)Tj 0.297 Tw 0 -1.218 TD (\027\017\004\036\f\022\017\005 \024\021\r\036\021, \023\030\017\027\016\035\ \030\036\001\036\027\017\036 \r\024\007\036\030\032\026\021\034\f\016 \ \024\021 )Tj 0.162 Tw 0 -1.218 TD (\f\021\030\026\021\036\020\017\017 \027\026\002\035\033\007\036\027\017\016\ \017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\t\035 \024\023\036\030\017\030\024)Tj 0 Tw (-)Tj 0.05 Tw 0 -1.218 TD (\r\026\027)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC (\027\036\020\024 \007\017\026\020\027\024\f\021\017\030\024\r\026\027 \023\ \024\035\027\t\005 \023\026\021\024\n\024\030\235\024\035\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\020\017\004\036\f\022\017\005 \024\021\r\036\021.)Tj 0.307 Tw 0 -1.218 TD [(\232\026\f\021\024\021\026 \023\024\035\027\t\b )0.5(\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b )0.5(\024\021\r\036\021\024\r \f\024)]TJ 0 Tw (-)Tj 0.2 Tw 0 -1.218 TD (\f\021\026\r\017\035\026 9/53 \(14,7%\) \023\030\024\021\017\r 6/51 \(9,\ 3%\), \f\024\024\021\r\036\021)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\f\021\r\036\027\027\024 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\). \210\002\013\026\016 \004\026\f\021\024\021\026 \023\024\035\027\t\ \b \024\021\r\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.109 Tw 0 -1.218 TD (14/61 \(22,9%\) \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 \022\031\030\ \f\026 \214\221 \017)Tj /Span<>> BDC ( )Tj EMC (17/64 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8662 730.483 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \004\027\032\027\025\031\024\022\026\031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\023\031\n\024\022\007\025\031\024\023\017 \n\031\025\024\031\f\022\030\022\ \032\r\005\212\027\235 \200\022\026\022\031\023\027\032\020\033\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.337 0 Td [( T)41.8(o)-5.3(le)-5.9(r)3.3(a)-0.9(b)-1.1(i)2.9(li)-3.4(t)-33.8(y a)-5(n)-4.8(d t)-3(o)-4.1(x)-30(i)-1.8(c)-30.1(i)-3.3(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(n)3.7(s)0.6(o)-5.3(li)-1.4(d)-2.5(a)-9.2(t)-29.1(i)-1.4(o)-4(n c)-2.4(h)-2.4(e)-7(m)-5.3(o)-2.9(t)-10.6(h)-2.4(e)-6(r)3.3(a)-5.2(p)-3.4(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8662 715.181 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1162 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 715.181 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 394.2657 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 490.6437 715.181 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6595 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8662 694.1118 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1162 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 694.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 694.1118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 682.6505 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1162 671.1893 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.502 682.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 682.6505 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 671.4393 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 671.1893 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 71.1162 659.978 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 184.252 671.1893 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 671.1893 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 297.8878 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 671.1893 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 394.2657 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 490.6437 659.978 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 659.978 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8662 659.728 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 659.728 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 659.728 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 394.2657 659.728 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 490.6437 659.728 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 110.9372 701.7465 Tm (\021\006\t\003\r\006\t\005)Tj 14.136 0 Td (\022\r\213\210\f\001\003\004\003)Tj 10.539 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (58\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj /T1_3 1 Tf 9.722 0.6 Td (\t)Tj /T1_0 1 Tf -53.953 -2.033 Td (\215\036\030\036\027\024\f\017\n\024\f\021\034)Tj 16.88 0 Td (\211\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\024)Tj 15.27 0 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(82%\))Tj 12.047 0 Td (52)Tj /Span<>> BDC ( )Tj EMC (\(85%\))Tj 9.423 0 Td (0,8)Tj -53.62 -1.433 Td (\221\024\022\f\017\004\027\024\f\021\034)Tj T* (\(NCI-CTCAE\))Tj 18.371 1.2 Td (1\2262 \f\021\036\023\036\027\017)Tj 14.279 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 11.797 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13%\))Tj 8.923 0 Td (0,19)Tj -35 -1.433 Td (3\2264 \f\021\036\023\036\027\017)Tj 14.279 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(9%\))Tj 12.047 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj ET q /GS0 gs 453.543294 0 0 209.493808 70.8661499 101.0429351 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \221\f\031\n-\024\200\027\026\020 \032\020\024\033\032\027\030\027\f\027\ \025\022\t \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC [(\033\031\f\025\013\026 \n\f\022\025\022\007\027\024)0.5(\n\022\026 \031\023\021\027\023\031\026)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf T* [(F)-16(igure 1)47.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( P)18(atient allocation f)-21.8(low char)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(patients with clinical com)16.3(plete response)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (120)Tj ET endstream endobj 850 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;w    m!1AQSTUa"235qt#BR$4bs %&'()*6789:CDEFGHIJVWXYZcdefghijruvwxyz?QQpQ55 $FS4v)rсû9ha݊~朴`}0?sNZ0>wb-L;OӖاiFS4v)rсû9ha݊~朴`}0?sNZ0>wb. ,Y52NJQV$5VaV0+Ww 62-o#X׬wP^xk"xp$d4q,?cìi99н4vm$sEucʏ6(&8$pnCs̀7oaØng&fxn fuVlӕ$F AP'ҍ3i4N-7^ \*)c&M =9k`7A_U *p՘"""""""""""""""""""""""""" QV$5VaV4 aYR'su uD C0֭` c>h:2hp[™ıX~B"3lA$Y<5YBIZG@`xZ{M4n)2 F-v7<`u}6a+aU q"6|!UiJs\7f%jQV$5VaV%_DDDDDDDDDDDDDDDDDDDDDDDDDDDQlB+k8s5p wO% %4g$-gp˼KMG]8~''86b- -3>&ĭ_NU7O 49[ Ht3 :!)>匽JFpX]i6ڴNК:6{|ܯ7[{:I/g~19[p1O_'Ƨ!gO^ByY 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obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-10(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ \026)11(\004\005\017\224\n\n \b\022\020\004\225\004\t\n\n \005\017\r\017 )]TJ 0 -1 TD [(\224\005\213\024\025\221 \r\n\204\r\n: \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 42.014 1 Td [(Ef)-31(f)-21(icacy of\022total neoadju)10(v)10(ant th)11(er)21.1(apy for r)31(ectal )]TJ 4.252 -1 Td [(cancer: r)31.1(esults of\022a\022r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.482 Tw 10 0 0 10 42.5197 371.6679 Tm (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\n\036\027\ \017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 )Tj 0 Tw 0 -1.218 TD (\217\024\f\f\017\017 26.09.2022 \020\024\007\026.)Tj /T1_2 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.11 Tw 0 -1.218 TD (\222\021\026\021\017\f\021\017\004\036\f\022\017\005 \026\027\026\035\017\  \023\030\024\r\024\007\017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \023\030\024)Tj 0 Tw (-)Tj 0.135 Tw T* [(\020\030\026\n\n\t S)15(t)15(a)15(t)-32(ist)-31.9(ica 13.3 \(TIBC)13(O, \222\231\202\) \017)]TJ /Span<>> BDC ( )Tj EMC [(RS)15(tudio \(R v. )]TJ -0.016 Tw T* [(4.4.1 \(R Cor)-23.9(e T)40(eam, \200\036\027\026, \202\r\f\021\030\017\016\)\). \215\030\024\r\036\030\ \022\026 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\027\024\030)Tj 0 Tw (-)Tj 0.249 Tw T* (\n\026\035\034\027\024\036 \030\026\f\023\030\036\007\036\035\036\027\017\ \036 \024\f\031\013\036\f\021\r\035\016\035\026\f\034 \022\030\017\021\036\ \030\017\036\n )Tj 0.403 Tw T* (\025\024\035\n\024\020\024\030\024\r\026\226\222\n\017\030\027\024\r\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\f \023\024\n\024\013\034\033 \r\017\031\026\035\034\027\024\005 )Tj -0.033 Tw T* [(\024\006\036\027\022\017 \020\017\f\021\024\020\030\026\n\n\t \030\026\f\ \023\030\036\007\036\035\036\027\017\016 )0.5(\004\026\f\021\024\021 \023\030\017\027\026\022\026. )]TJ 0.156 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\017 \206\026\031\f\f\024\r\026 \030\026\f\023\030\036\ \007\036\035\036\027\017\016 \027\036\023\030\036\030\t\r\027\t\036 )Tj 0.179 Tw T* (\007\026\027\027\t\036 \024\023\017\f\t\r\026\035\017\f\034 \f\030\036\007\ \027\017\n\017 \027\026\004\036\027\017\016\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027)Tj 0 Tw (-)Tj 0.08 Tw T* (\007\026\030\021\027\t\n\017 \024\021\022\035\024\027\036\027\017\016\n\017\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 M)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD; \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b )Tj 0.226 Tw T* (\f\035\031\004\026\016\b)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\007\017\026\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\022\r\026\030\021\017\035\034\027\t\n \030\026\n\026\b\024\n\ )Tj -0.019 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 Me \(IQR\). \222\030\026\r\027\036\027\017\036 \020\030\031\ \023\023 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\036\027\027\t\n )Tj 0.125 Tw T* [(\023\030\017\027\026\022\026\n )0.6(\r\027\036 )0.5(\026\r\017\f\017\n\024\f\021\017 )0.6(\024\021 )0.5(\b\026\030\026\022\021\036\030\026 )0.5(\030\026\f\023\030\036\007\036)]TJ 0 Tw (-)Tj 0.427 Tw T* (\035\036\027\017\016 \024\f\031\013\036\f\021\r\035\016\035\026\f\034 U-\ \022\030\017\021\036\030\017\036\n \204\026\027\027\026\226\211\017\021\027\ \017, )Tj 0.039 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\n)Tj /Span<>> BDC ( )Tj EMC (\227 \245)Tj 0 Tw 5.83 0 0 5.83 134.4544 167.9718 Tm (2)Tj 0.039 Tw 10 0 0 10 137.3694 164.6418 Tm ( \215\017\030\f\024\027\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\036\n\t\b \027\026)Tj 0 Tw (-)Tj 0.044 Tw -9.485 -1.218 Td (\004\036\027\017\016\b \002\024\035\036\036 10 \007\035\016 \r\f\036\b \016\ \004\036\036\022 \007\035\016 \004\036\021\t\030\036\b\023\024\035\034\027\ \t\b )Tj 0.199 Tw T* (\021\026\002\035\017\006 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 5)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036 \n\036\027\036\036 \004\036\n \007\035\016 20% \016\004\036\ \036\022 )Tj -0.022 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\023\024\035\034\027\t\b, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\035\034\027\t\b \f\035\031\004\026\016\b \023\030\017\n\036\ \027\016\035\017 \007\r\031)Tj 0 Tw (-)Tj -0.06 Tw T* [(\f\021\024\030\024\027\027\017\005 )0.5(\021\024\004\027\t\005 \022\030\017\021\036\030\017\005 )0.5(\205\017\001\036\030\026. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\036 \002\036)Tj 0 Tw (-)Tj -0.034 Tw T* (\030\036\006\017\007\017\r\027\024\005 \r\t\032\017\r\026\036\n\024\f\021\ \017 \r\t\f\004\017\021\t\r\026\035\017 \023\030\024\n\036\032\031\021\024\ \022 )Tj 0.145 Tw T* (\r\030\036\n\036\027\017 \024\021 \007\026\021\t \027\026\004\026\035\026\ \035\036\004\036\027\017\016 \007\024)Tj /Span<>> BDC ( )Tj EMC (\007\026\021\t \030\036\006\017\007\017\r\026 )Tj 0.451 Tw T* (\017\035\017 \023\024\f\035\036\007\027\036\020\024 \022\024\027\021\030\ \024\035\016. \210\006\036\027\022\026 \r\t\032\017\r\026\036\n\024\f\021\ \017 )Tj 0.429 Tw 23.244 29.227 Td (\023\030\024\r\024\007\017\035\026\f\034 \023\031\021\036\n \023\024\f\021\ \030\024\036\027\017\016 \022\030\017\r\t\b \025\026\023\035\026\027\026\ \226)Tj 0.034 Tw T* (\204\026\005\036\030\026, \f\030\026\r\027\036\027\017\036 \020\030\031\023\ \023 \024\f\031\013\036\f\021\r\035\016\035\017 \035\024\020\030\026\027\ \020\024\r\t\n )Tj 0.125 Tw T* (\021\036\f\021\024\n. \217\026\035\017\004\017\016 \f\004\017\021\026\035\ \017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\ \n\017 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 298.5999 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.017 Tw 10 0 0 10 274.9606 274.2439 Tm (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\004\036\027\ \t 125 \023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b )Tj -0.026 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \022\024\030\024\021\022\024\020\024 \022\031\030\ \f\026 \214\221)Tj /Span<>> BDC ( )Tj EMC (\227 61 \023\026\006\017\036\027\021, \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 )Tj 0 Tw T* (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005 \216\214\221\ )Tj /Span<>> BDC ( )Tj EMC (\227 64 \023\026\006\017\036\027\021\026.)Tj -0.016 Tw T* (\206\030\031\023\023\t \002\t\035\017 \f\024\023\024\f\021\026\r\017\n\t\ \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\031, \r\024\030\026\f\021\031, \030\026\n\036\030\031 )Tj -0.001 Tw T* (\024\023\031\b\024\035\017, \027\026\035\017\004\017\033 \017\035\017 \024\ \021\f\031\021\f\021\r\017\033 \r\024\r\035\036\004\036\027\017\016 \006\ \017\030\022\031)Tj 0 Tw (-)Tj 0.195 Tw T* (\035\016\030\027\024\020\024 \022\030\026\016 \030\036\036\022\006\017\017\ \017\035\017 \017\027\r\026\017\017 \220\022\f\021\030\026\n\031\030\026\ \035\034)Tj 0 Tw (-)Tj T* (\027\t\b \f\024\f\031\007\024\r \007\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\026 \035\036\004\036\027\017\016 \(\221\026\002\035\ . 1\).)Tj 0.059 Tw T* (\200 \024\002\036\017\b \020\030\031\023\023\026\b \023\024\035\031\004\036\ \027\t \f\024\023\024\f\021\026\r\017\n\t\036 \030\036\031\035\034\021\026\ \021\t )Tj -0.025 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\035\026\036\027\021\027\024\f\021\017, \023\036\030\036\027\ \024\f\017\n\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\022\f\017\004\027\024\f\021\017 \035\031)Tj 0 Tw (-)Tj 0.08 Tw T* [(\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 )0.6(\(\221\026\002\035.)]TJ /Span<>> BDC ( )Tj EMC 9.286 0 Td [(2\). )0.5(\200\f\036 )0.5(\023\026\006\017\036\027\021\t )0.6(\023\030\024\001\035\017 )0.5(\023\024\035)]TJ 0 Tw (-)Tj 0.072 Tw -9.286 -1.218 Td (\027\t\005 \022\031\030\f \214\221/\216\214\221, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \021\024\022\f\017\004\027\024\f\021\034 3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\023\036\027\017 )Tj 0.263 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 R)-12(T)19.9(OG \026\030\036\020\017\f\021\030\017\030\024\r\026\027\026 \031)]TJ /Span<>> BDC ( )Tj EMC (2% \023\026\006\017\036\027\021\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\t.)Tj 0.126 Tw T* (\025\024\n\023\035\026\036\027\021\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\026)Tj 0 Tw (-)Tj -0.052 Tw T* (\004\017\n\024 \027\036 \030\026\035\017\004\026\035\026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b. \215\024)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\n \023\030\017)Tj 0 Tw (-)Tj 0.003 Tw T* (\004\017\027\026\n \022\024\027\f\024\035\017\007\017\030\031\033\013\026\ \016 \b\017\n\017\024\021\036\030\026\023\017\016 \027\036 \002\t\035\026\ \023\030\024)Tj 0 Tw (-)Tj T* (\r\036\007\036\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (5% \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\t \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \b\032\r\033\033)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.002 Tc -0.002 Tw 3.324 0 Td [( C)0.9(h)2.4(a)-2.2(r)5.3(a)-7.2(c)-30.3(te)-4(r)-37(i)8.6(s)-12.8(t)-27.1(ic)-24.7(s)2( o)6.1(f)]TJ /Span<>> BDC 7.087 0 Td ( )Tj EMC [(g)0.5(ro)-1.4(up)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 195.8405 715.181 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 715.181 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 715.181 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 694.1118 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 682.6505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.8405 694.1118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 195.8405 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 694.1118 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 694.1118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 682.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 682.6505 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 671.4392 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 682.6505 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 195.8405 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 682.6505 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 682.6505 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 671.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 671.4392 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 671.1892 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 195.8405 671.1892 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 671.1892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 671.1892 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 671.1892 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 650.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 650.1279 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 195.8405 650.1279 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 650.1279 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 650.1279 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 650.1279 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 629.3167 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 629.0667 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 617.6053 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.8405 629.0667 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 195.8405 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 629.0667 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 629.0667 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 629.0667 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 617.8553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 617.6053 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 606.394 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 617.6053 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 195.8405 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 617.6053 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 617.6053 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 606.394 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 606.394 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 606.144 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 42.7697 594.6827 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.8405 606.144 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 195.8405 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 606.144 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 606.144 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 606.144 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 594.9327 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 594.6827 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 583.4715 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 594.6827 cm 0 0 m 73.951 0 l S Q q 1 0 0 1 195.8405 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 594.6827 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 594.6827 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 583.4715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 583.4715 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 583.2215 cm 0 0 m 153.321 0 l S Q q 1 0 0 1 195.8405 583.2215 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 269.5413 583.2215 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 583.2215 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 462.2972 583.2215 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_5 1 Tf 0 Tc 0 Tw 8 0 0 8 139.4158 701.7464 Tm (\200\004\006\004\214\r\003\006)Tj 17.571 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_2 1 Tf 9.722 0.6 Td (\t)Tj /T1_1 1 Tf -53.953 -2.033 Td (\215\024\035)Tj 22.501 0 Td (\204\031\032)Tj 9.649 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(59%\))Tj 12.047 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj 9.423 0 Td (0,3)Tj -31.13 -1.433 Td (\240\036\027)Tj 9.66 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(41%\))Tj 12.047 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj -44.197 -1.433 Td (\200\024\030\026\f\021, \035\036\021, \204)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (SD \(Min\226Max\) )Tj 31.848 0 Td (63,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (10,9)Tj 0.52 -1.2 Td (\(31\22680\))Tj 11.527 1.2 Td (62,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (11,4)Tj 0.52 -1.2 Td (\(29\22683\))Tj 9.205 1.2 Td (0,3)Tj -53.62 -2.633 Td (\217\026\n\036\030 \024\023\031\b\024\035\017, \n\n)Tj T* (\204\036 \(Q1\226Q3\))Tj 31.501 1.2 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(24\226123\))Tj 12.297 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(27\22676\))Tj 9.822 0 Td (0,4)Tj -53.62 -2.633 Td (\037\017\030\022\031\035\016\030\027\t\005 \022\030\026\005 \030\036\036\ \022\006\017\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016)Tj 22.305 0 Td (CRM+)Tj 9.844 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(51%\))Tj 12.047 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(52%\))Tj 9.423 0 Td (0,9)Tj -31.343 -1.433 Td (CRM\226)Tj 9.872 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(49%\))Tj 12.047 0 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(48%\))Tj -44.197 -1.433 Td (\230\027\r\026\017\016 \220\022\f\021\030\026\n\031\030\026\035\034\027\ \t\b \f\024\f\031\007\024\r )Tj 0 -1.2 TD (\007\024)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\016)Tj 22.124 1.2 Td (EMVI+)Tj 10.026 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(38%\))Tj 12.047 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(36%\))Tj 9.423 0 Td (0,8)Tj -31.524 -1.433 Td (EMVI\226)Tj 10.054 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(62%\))Tj 12.047 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(64%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 566.5022 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \033\032\031\021\027\030\027\025\022\ \t \f\r\007\027\021\031\235 \023\027\032\020\033\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf -0.003 Tc 0.003 Tw 3.334 0 Td [( Re)-25(s)3.7(u)-4.6(l)2.3(t)-35.9(s)-3( o)1(f)]TJ /Span<>> BDC 4.088 0 Td ( )Tj EMC [(ra)-11.7(d)-6(i)-1.5(a)-12.2(t)-32.1(i)-4.4(o)-6.9(n)-3( t)-13.6(h)-5.4(e)-9(ra)-8.2(p)-6.4(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 551.2003 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 551.2003 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 269.5413 551.2003 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 551.2003 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 551.2003 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 530.381 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 530.131 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 530.131 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 530.131 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 530.131 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 530.131 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 518.9197 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 518.6697 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 518.6697 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 518.6697 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 518.6697 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 518.6697 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 507.4585 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 507.2085 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 495.7472 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 156.1555 507.2085 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 507.2085 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 507.2085 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 507.2085 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 495.9972 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 495.7472 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 484.5359 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 155.9055 495.7472 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 495.7472 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 495.7472 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 484.5359 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 484.5359 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 484.2859 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 484.2859 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 484.2859 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 484.2859 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 462.2972 484.2859 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_5 1 Tf 0 Tc 0 Tw 8 0 0 8 82.5907 537.7657 Tm (\021\006\t\003\r\006\t\005)Tj 14.136 0 Td (\022\r\213\210\f\001\003\004\003)Tj 10.539 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_2 1 Tf 9.722 0.6 Td (\t)Tj /T1_1 1 Tf -53.953 -2.033 Td (\025\024\n\023\035\026\036\027\021\027\024\f\021\034)Tj 16.662 0 Td (\211\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\026\016)Tj 15.238 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 12.047 0 Td (64)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 9.988 0 Td (\226)Tj -53.935 -1.433 Td (\215\036\030\036\027\024\f\017\n\024\f\021\034)Tj 16.662 0 Td (\211\007\024\r\035\036\021\r\024\030\017\021\036\035\034\027\026\016)Tj 15.488 0 Td (59)Tj /Span<>> BDC ( )Tj EMC (\(96%\))Tj 12.047 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(94%\))Tj 9.423 0 Td (0,7)Tj -53.62 -1.433 Td (\221\024\022\f\017\004\027\024\f\021\034 \(RTOG\))Tj 18.371 0 Td (1\2262 \f\021\036\023\036\027\017)Tj 14.279 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 12.047 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 8.923 0 Td (0,8)Tj -35.25 -1.433 Td (3\2264 \f\021\036\023\036\027\017)Tj 14.279 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 12.047 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 467.5666 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \202\031\026\033\f\020\027\025\023\025\031\024\023\017 \n)Tj /Span<>> BDC ( )Tj EMC (\n\031\025\024\031\f\022\030\022\032\r\005\212\027\235 \200\022\026\022\031\ \023\027\032\020\033\022\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.318 0 Td [( C)1.2(o)-4(m)-1(p)-4.9(li)1.5(a)-5.1(n)-2.9(c)2.8(e w)-26.7(i)-3.4(t)-10.6(h c)2.9(o)-4(n)3.7(s)0.5(o)-5.3(li)-1.4(d)-2.5(a)-9.1(t)-29.2(i)4(n)-0.6(g c)-2.5(h)-2.4(e)-7(m)-5.3(o)-2.9(t)-10.6(h)-2.4(e)-6(r)3.4(a)-5.2(p)-3.4(y)]TJ ET /GS2 gs q 1 0 0 1 42.5197 452.2646 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 156.1555 452.2646 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 269.5413 452.2646 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 452.2646 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 462.2972 452.2646 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 431.4454 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 431.1954 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 42.7697 419.7341 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 156.1555 431.1954 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 156.1555 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 431.1954 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 431.1954 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 431.1954 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 419.9841 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 419.7341 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 408.2728 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 155.9055 419.7341 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 419.7341 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 419.7341 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 408.5228 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 408.2728 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 42.7697 397.0616 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 155.9055 408.2728 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 408.2728 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 269.5413 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 408.2728 cm 0 0 m 96.628 0 l S Q q 1 0 0 1 365.9193 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 397.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 397.0616 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 396.8116 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 156.1555 396.8116 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 269.5413 396.8116 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 365.9193 396.8116 cm 0 0 m 96.378 0 l S Q q 1 0 0 1 462.2972 396.8116 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 82.5907 438.83 Tm (\021\006\t\003\r\006\t\005)Tj 14.136 0 Td (\022\r\213\210\f\001\003\004\003)Tj 10.539 0.6 Td (25 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 2.886 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (61\))Tj 8.735 1.2 Td (50,4 \027\006)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (3 \220\210\006\217\004 XELOX)Tj 3.312 -1.2 Td (\(N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (64\))Tj /T1_2 1 Tf 9.722 0.6 Td (\t)Tj /T1_1 1 Tf -53.953 -2.033 Td (\025\024\n\023\035\026\036\027\021\027\024\f\021\034)Tj 16.886 0 Td (\215\030\024\001\035\017 3 \022\031\030\f\026 \b/\021)Tj 15.264 0 Td (54)Tj /Span<>> BDC ( )Tj EMC (\(88%\))Tj 12.047 0 Td (57)Tj /Span<>> BDC ( )Tj EMC (\(89%\))Tj 9.423 0 Td (1,0)Tj -37.1 -1.433 Td (\215\030\024\001\035\017 1\2262)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\026 \216\221)Tj 16.13 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(7%\))Tj 12.047 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj -26.079 -1.433 Td (\210\021\022\026 \024\021 \216\221)Tj 14.032 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 12.047 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 504.6646 56.0378 Tm (119)Tj ET endstream endobj 847 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.016 Tc 0.295 Tw 10 0 0 10 70.8661 724.8299 Tm (\200 \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n \017\f\f\ \035\036\007\024\r\026\027\017\017 RAPIDO \023\024)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.224 Tw 0 -1.218 TD (\022\026\026\027\024 \023\030\036\017\n\031\013\036\f\021\r\024 \221\203\ \221, \r\022\035\033\004\026\033\013\036\005 \023\030\024\r\036\007\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.05 Tw T* [(\027\017\036 \022\024\030\024\021\022\024\020\024 \022\031\030\f\026 \022\ \030\031\023\027\024-\235\030\026\022\006\017\024\027\027\024\005 \035\031\ \004\036\r\024\005)16( )]TJ 0.206 Tw T* [(\021\036\030\026\023\017\017 \222\210\212 )0.5(25 \206\030 \f)]TJ /Span<>> BDC ( )Tj EMC 9.855 0 Td (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ \021\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.207 Tw -9.855 -1.218 Td (\030\026\023\017\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\n \022\031\030\f\ \024\n)16( )]TJ 0.148 Tw T* (\216\214\221 \222\210\212 50,4 \206\030. \232\026\f\021\024\021\026 \023\ \024\035\027\t\b \023\026\021\024\n\024\030\235\024\035\024\020\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.184 Tw 0 -1.218 TD (\004\036\f\022\017\b \024\021\r\036\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221 \f\024\f\021\026\r\017\035\026 28%\ , \021\024\020)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.297 Tw 0 -1.218 TD (\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\035\024\027\020\017\030\024\r\026\027\ \027\024\005 \216\214\221)Tj /Span<>> BDC ( )Tj EMC [(\227 14%)16( )]TJ 0 Tc 0 Tw T* (\()Tj /T1_1 1 Tf 0.386 0 Td (p)Tj /T1_0 1 Tf 0.016 Tc /Span<>> BDC 0.494 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\))Tj /Span<>> BDC ( )Tj EMC ([4].)Tj 0 Tc 0.301 Tw -0.88 -1.218 Td (\221\024\021\026\035\034\027\026\016 \027\036\024\026\007\255\033\r\026\027\ \021\027\026\016 \021\036\030\026\023\017\016 \017\n\036\036\021 \023\030\ \036\r\024\f)Tj 0 Tw (-)Tj 0.04 Tw T* (\b\024\007\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC 4.249 0 Td [(\f\030\026\r\027\036\027\017\017 )0.5(\f\024 \f\021\026\027\007\026\030\021\027\t\n )0.5(\030\036\032\017\n\024\n \023\030\036\007)]TJ 0 Tw (-)Tj 0.284 Tw -4.249 -1.218 Td (\024\023\036\030\026\006\017\024\027\027\024\005 \216\214\221, \024\007\027\ \026\022\024 \024\f\021\026\036\021\f\016 \024\021\022\030\t\021\t\n \r\024\ )Tj 0 Tw (-)Tj 0.056 Tw 0 -1.218 TD (\023\030\024\f \r\t\002\024\030\026 \030\036\032\017\n\026 \035\031\004\036\ \r\024\005 \021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \221\203\221. )Tj 0.25 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\f\022\036 \035\017\021\036\030\026\021\031\030\t \027\036 \027\ \026\005\007\036\027\024 \017\f\f\035\036\007\024\r\026\027\017\005, )Tj 0.065 Tw 0 -1.218 TD (\022\024\021\024\030\t\036 \f\030\026\r\027\017\r\026\033\021 \030\036\031\ \035\034\021\026\021\t \035\036\004\036\027\017\016 \n\036\f\021\027\024\ \030\026\f)Tj /Span<>> BDC (-)Tj EMC 0.141 Tw T* (\023\030\024\f\021\030\026\027\036\027\027\024\020\024 \030\026\022\026 \ \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\026\b \221\203\221 )Tj -0.009 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \022\024\030\024\021\022\024\020\ \024 \022\031\030\f\026 \214\221 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027)Tj 0 Tw (-)Tj -0.019 Tw T* (\027\024\020\024 \022\031\030\f\026 \216\214\221, \r)Tj /Span<>> BDC ( )Tj EMC [(\f\r\016\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\004\036\n \027\026\n\017 \002\t\035\024 \017\027\017\006\017\017\030\024\ \r\026)Tj 0 Tw (-)Tj T* (\027\024 \007\026\027\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 469.0918 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.03 Tw 10 0 0 10 70.8661 444.7358 Tm [(\222 \f\036\027\021\016\002\030\016 )0.5(2022 \023\024)]TJ /Span<>> BDC ( )Tj EMC 8.265 0 Td [(\235\036\r\030\026\035\034 )0.5(2025 \020\020. )0.5(\023\030\024\r\036\007\036\027\024 )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.905 Tw -8.265 -1.218 Td (\f\023\036\022\021\017\r\027\024\036, \024\007\027\024\006\036\027\021\030\ \024\r\024\036, \030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\ \036 )Tj 0.414 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036, \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\036 \r\022\035\033\004\036\027\024 125 \004\036\ \035\024\r\036\022. )Tj -0.023 Tw T* [(\230\f\f\035\036\007\024\r\026\027\017\036 )0.5(\007\r\031\b\020\030\031\023\023\024\r\024\036, \030\026\027\007\024\n\017\ \026\006\017\016 )0.5(1:1 \023\030\024)]TJ 0 Tw (-)Tj 0.344 Tw T* (\017\r\024\007\017\035\026\f\034 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \030\026\027\007\024\n\026\005\036\030\026 \007\035\ \016 \004\017\f\036\035 )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\b r)-32.9(and)-16(omus.r)-21.9(u.)]TJ /T1_1 1 Tf T* (\206\020\024\033\032\027\030\027\f\027\025\022\027 \033\020\006\022\027\025\ \023\031\021:)Tj /T1_0 1 Tf 0.054 Tw T* (\200 \020\030\031\023\023\036 \202)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \023\030\024\r\024\007\017\035\f\016 \ \022\024\030\024\021\022\017\005 \022\031\030\f \035\031)Tj 0 Tw (-)Tj 0.089 Tw T* (\004\036\r\024\005 \021\036\030\026\023\017\017 \(\214\221\) \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n\016 \022\031\030\f\026\n\017 \022\024\027\f\024\035\017\007\ \017\030\031\033)Tj 0 Tw (-)Tj -0.044 Tw T* [(\013\036\005 )0.5(\b\017\n\017\024\021\036\030\026\023\017\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 9.128 0 Td [(\f\b\036\n\036 )0.5(XEL)35(O)17(X )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\024\006\036\027\022\024\005 )0.6(\220\235\235\036\022\021\026 )]TJ 0 Tw -9.128 -1.218 Td (\004\036\030\036 10\22618)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\016 \214\221.)Tj 0.137 Tw T* (\200 \020\030\031\023\023\036 \207 \023\030\024\r\024\007\017\035\f\016 \ \023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\005 \022\031\030\ \f \b\017)Tj 0 Tw (-)Tj 0.03 Tw T* (\n\017\024\035\031\004\036\r\024\005 \021\036\030\026\023\017\017 \(\216\ \214\221\) \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\n\016 \022\031\030\f\026\n\017 \022\024\027\f\024\035\017)Tj 0 Tw (-)Tj 0.139 Tw T* (\007\017\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\ \017 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\f\b\036\n\036 XEL)35(O)17(X \f)]TJ /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\024\005 )Tj 0 Tw T* (\220\235\235\036\022\021\026 \004\036\030\036 10\22618)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\016 \216\214\221.)Tj 0.436 Tw T* (\215\024\035\027\t\005 \022\035\017\027\017\004\036\f\022\017\005 \024\021\ \r\036\021 \(cCR\) \031\f\021\026\027\026\r\035\017\r\026\035\f\016 )Tj 0.107 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \007\026\027\027\t\b \023\026\035\034\006\ \036\r\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016, \022\024)Tj 0 Tw (-)Tj 0.008 Tw T* [(\035\024\027\024\f\022\024\023\017\017, )0.5(\204\217\221 \024\030\020\026\027\024\r )0.5(\n\026\035\024\020\024 \021\026\026 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.641 0 Td (\024\021\f\031\021\f\021\r\017\017 )Tj 0.46 Tw -17.641 -1.218 Td [(\n\026\022\030\024\f\022\024\023\017\004\036\f\022\017\b )0.5(\023\030\017\027\026\022\024\r \024\023\031\b\024\035\017 )0.5(\004\036\030\036 10\226)]TJ 0.213 Tw T* (18)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\035\034 \023\024\f\035\036 \024\022\024\027\004\026\027\ \017\036 \035\031\004\036\r\024\005/\b\017\n\017\024\035\031\004\036\r\024\ \005 )Tj 0.066 Tw T* (\021\036\030\026\023\017\017. \200)Tj /Span<>> BDC ( )Tj EMC (\f\035\031\004\026\036 \022\024\027\f\021\026\021\026\006\017\017 \023\024\ \035\027\024\020\024 \022\035\017\027\017\004\036\f\022\024)Tj 0 Tw (-)Tj 0.089 Tw T* (\020\024 \024\021\r\036\021\026 \024\023\031\b\024\035\017, \023\026\006\ \017\036\027\021\026\n \023\030\036\007\035\026\020\026\035\024\f\034 \007\ \017\027\026\n\017)Tj 0 Tw (-)Tj 0.071 Tw T* [(\004\036\f\022\024\036 \027\026\002\035\033\007\036\027\017\036, )0.5(\f\024\020\035\026\f\027\024 \f\021\030\026\021\036\020\017\017 )0.5(\027\026\002\035\033\007\036\027\017\016 )]TJ 0.039 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\024\032\017\007\026\027\017\016 \(\253w)-12(a)15(tch and w)-12(ai)-24(t\273\). \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\017 \023\024\035)Tj 0 Tw (-)Tj -0.015 Tw T* (\027\024\020\024 \022\035\017\027\017\004\036\f\022\024\020\024 \030\036\ \020\030\036\f\f\026 \024\023\031\b\024\035\017, \023\026\006\017\036\027\ \021\026\n \023\030\024)Tj 0 Tw (-)Tj T* (\r\024\007\017\035\024\f\034 \b\017\030\031\030\020\017\004\036\f\022\024\ \036 \035\036\004\036\027\017\036.)Tj 0.17 Tw T* [(\215\024\035\027\t\005 \023\026\021\024\n\024\030\235\024\035\024\020\017\ \004\036\f\022\017\005 )0.5(\024\021\r\036\021 \(pCR\) \031\f\021\026\027\026\r)]TJ 0 Tw (-)Tj 0.008 Tw T* (\035\017\r\026\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\026\027\017\017 \n\024\030\235\024\035\024\020\017\004\036\ \f\022\024\020\024 \017\f\f\035\036\007\024\r\026)Tj 0 Tw (-)Tj 0.113 Tw T* (\027\017\016 \024\023\036\030\026\006\017\024\027\027\024\020\024 \n\026\ \021\036\030\017\026\035\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024\n \030\036\020\030\036\f\f\036 )Tj 0.101 Tw T* (\026\007\036\027\024\022\026\030\006\017\027\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\031\021\f\021\r\017\016 \n\036\021\026\f\021\026\021\017\004\036\ \f\022\017 \017\n\036)Tj 0 Tw (-)Tj T* (\027\036\027\027\t\b \035\017\n\235\024\031\035\024\r.)Tj -0.021 Tw 23.244 64.543 Td [(\206\017\023\024\021\036\026 \017\f\f\035\036\007\024\r\026\027\017\016\ : )0.5(\022\024\n\002\017\027\026\006\017\016 \022\024\030\024\021\022\024\020\024\ )0.5(\022\031\030\f\026 )]TJ 0.059 Tw 0 -1.218 TD [(\035\031\004\036\r\024\005 )0.6(\021\036\030\026\023\017\017 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 8.009 0 Td [(\022\031\030\f\024\n )0.5(\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 )0.6(\b\017\n\017\024)]TJ 0 Tw (-)Tj 0.17 Tw -8.009 -1.218 Td (\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\n \030\036\032\017\n\036\ \027\036 \b\031\032\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tw (-)Tj 0.019 Tw 0 -1.218 TD (\f\021\024\021\036 \023\024\035\027\t\b \024\021\r\036\021\024\r \024\023\ \031\b\024\035\017 \023\030\016\n\024\005 \022\017\001\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj 0.344 Tw 0 -1.218 TD (\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\t\n \022\031\030\f\ \024\n \b\017\n\017\024\035\031\004\036\r\024\005 )Tj 0 Tw 0 -1.218 TD (\021\036\030\026\023\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\031\030\f\024\n \022\024\027\f\024\035\017\007\017\030\031\033\013\036\ \005 \b\017\n\017\024\021\036\030\026\023\017\017.)Tj /T1_1 1 Tf 0 -1.218 TD (\202\032\022\023\027\032\022\022 \021\n\f\005\007\027\025\022\t:)Tj /T1_0 1 Tf 0 -1.218 TD (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\202\007\036\027\024\022\026\030\006\017\027\024\n\026 \023\030\016\n\024\ \005 \022\017\001\022\017 cT3-T4\026N0-2M0;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td [(\210\006\036\027\022\026 \024\002\013\036\020\024 \f\024\f\021\024\016\027\ \017\016 \002\024\035\034\027\024\020\024 EC)13.2(OG 0-2;)]TJ 0.012 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-255( )]TJ EMC 1 0 Td [(\215\024\007\023\017\f\026\027\027\024\036 )0.6(\007\024\002\030\024\r\024\035\034\027\024\036 )0.5(\017\027\235\024\030\n\017\030\024\r\026\027\027\024\036 )0.6(\f\024)]TJ 0 Tw (-)Tj T* (\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj /T1_1 1 Tf -1 -1.218 Td (\202\032\022\023\027\032\022\022 \025\027\021\n\f\005\007\027\025\022\t:\ )Tj /T1_0 1 Tf T* (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\200\024\030\026\f\021 \n\036\027\036\036 18 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 80 \035\036\021;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\217\036\006\017\007\017\r \030\026\022\026 \023\030\016\n\024\005 \022\017\ \001\022\017;)Tj 1.761 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )1494( )]TJ EMC 1 0 Td (\215\036\030\r\017\004\027\024-\n\027\024\032\036\f\021\r\036\027\027\t\036\ \024\023\031\b\024\035\017 \007\030\031\020\017\b )Tj 0 Tw T* (\035\024\022\026\035\017\026\006\017\005;)Tj -0.029 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-296( )]TJ EMC 1 0 Td (\215\030\036\007\001\036\f\021\r\031\033\013\026\016 \035\031\004\036\r\026\ \016 \021\036\030\026\023\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\t \n\026\035\024)Tj 0 Tw (-)Tj T* (\020\024 \021\026\026;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\207\036\030\036\n\036\027\027\024\f\021\034, \022\024\030\n\035\036\027\ \017\036 \020\030\031\007\034\033;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\203\026\035\017\004\017\036 \024\021\007\026\035\036\027\027\t\b \n\036\ \021\026\f\021\026\024\r;)Tj 0.694 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )427( )]TJ EMC 1 0 Td (\203\026\035\017\004\017\036 \b\030\024\027\017\004\036\f\022\017\b \026\ \002\024\035\036\r\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 )Tj 0 Tw T* (\007\036\022\024\n\023\036\027\f\026\006\017\017;)Tj -0.044 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-311( )]TJ EMC 1 0 Td [(\210\f\035\024\032\027\036\027\027\t\005 )0.6(\b\026\030\026\022\021\036\030 )0.5(\024\023\031\b\024\035\017 )0.5(\(\023\026\030\026\021\031\n\024\030\026\035\034\027\t\005 )]TJ 0 Tw T* (\026\002\f\006\036\f\f, \026\027\036\n\017\016 Hb)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (100 \020/\035\).)Tj /T1_1 1 Tf -1 -1.218 Td (\202\032\022\023\027\032\022\022 \022\024\n\f\005\007\027\025\022\t:)Tj /T1_0 1 Tf T* (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\210\021\022\026 \023\026\006\017\036\027\021\026 \024\021 \031\004\026\ \f\021\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017)Tj 0.088 Tw -1 -1.218 Td (\215\036\030\r\017\004\027\026\016 \021\024\004\022\026: \004\026\f\021\024\ \021\026 \023\024\035\027\t\b \024\021\r\036\021\024\r \(\022\035\017\027\ \017\004\036)Tj 0 Tw (-)Tj T* (\f\022\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b\)\ .)Tj T* (\200\021\024\030\017\004\027\t\036 \021\024\004\022\017:)Tj 0.055 Tw T* (\251)Tj /Span<>> BDC [( )-212( )]TJ EMC 1 0 Td (\022\024\n\023\035\026\036\027\021\027\024\f\021\034 \022)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\005 \021\036\030\026\023\ \017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tw (-)Tj 0.094 Tw T* (\n\036\027\036\027\017\036\n \022\024\030\024\021\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\020\024 \022\031\ \030\f\024\r )Tj 0 Tw T* (\214\221;)Tj 0.131 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-136( )]TJ EMC 1 0 Td (\004\026\f\021\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\026 \017\027\021\030\026- \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\022\035\026\f\f\017\235\017\022\026\006\017\017 Cl)-15.8(av)-15.9(ien\226Dind)-16(o [5];)]TJ 0.045 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-222( )]TJ EMC 1 0 Td [(\004\026\f\021\024\021\026 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(3\2264)]TJ /Span<>> BDC ( )Tj EMC 10.576 0 Td [(\f\021\036\023\036\027\017 )0.6(\035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017 )]TJ 0.094 Tw -10.576 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\036 )0.5(R)-12(T)20(OG )0.5([6] \017)]TJ /Span<>> BDC ( )Tj EMC 9.001 0 Td [(\b\017\n\017\024\021\036\030\026\023\017\017 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 7.554 0 Td [(\001\022\026\035\036 )0.5(\021\024\022)]TJ 0 Tw (-)Tj -16.555 -1.218 Td [(\f\017\004\027\024\f\021\017 NCI-CT)35.1(C)20(AE [7];)]TJ -0.233 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\022\026\004\036\f\021\r\024 )-233(\n\036\024\030\036\022\021\031\n\220\022\021\024\n\017\017;)]TJ T* (\251)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\004\026\f\021\024\021\026 )-233(R0-\030\036\036\022\006\017\005.)]TJ 0.044 Tw T* (\215\030\017 \n\024\013\027\024\f\021\017 \017\f\f\035\036\007\024\r\026\ \027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 80%, \007\024\r\036\030\017\021\036\035\034\027\024\n )Tj 0.062 Tw T* (\017\027\021\036\030\r\026\035\036)Tj /Span<>> BDC ( )Tj EMC (\227 95%, \024\032\017\007\026\036\n\024\005 \r\036\035\017\004\017\027\036\ \220\235\235\036\022\021\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.019 Tw T* (\n\036\027\036\036 10% \(\023\030\017\n\036\027\036\027\017\036 \022\024\ \030\024\021\022\024\020\024 \022\031\030\f\026 \214\221 \027\036 \b\031\ \032\036, )Tj 0.354 Tw T* (\004\036\n \023\030\024\035\024\027\020\017\030\024\r\026\027\027\024\005\ \216\214\221 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\n\022\026\b \023\030\024\r\036\007\036\027\017\016 )Tj 0.119 Tw T* (\221\203\221\), \017)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\036\n\024\005 \004\026\f\021\024\021\036 \023\024\035\ \027\t\b \024\021\r\036\021\024\r \024\023\031\b\024\035\017 )Tj 0.291 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(20\22630%, )0.5(\030\026\n\036\030 \r\t\002\024\030\022\017, )0.5(\f\024\020\035\026\f\027\024 )0.5(\020\017\023\024\021\036\036 \027\036 )]TJ 0.043 Tw T* [(\n\036\027\034\001\036\005 \220\235\235\036\022\021\017\r\027\024\f\021\017\ \(\253non-infer)-36.9(ior)-37(i)-23.9(t)-10(y tr)-36.9(ial\273\), \f\024)]TJ 0 Tw (-)Tj 0.112 Tw T* (\f\021\026\r\035\016\036\021 \023\024)Tj /Span<>> BDC ( )Tj EMC (250 \023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\031. \200)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.248 Tw T* (\024\021\r\036\021\f\021\r\017\036\n \r\036\035\017\004\017\027\t \220\235\ \235\036\022\021\026 \024\032\017\007\026\036\n\024\005 \(\n\036\027\036\ \036 )Tj -0.034 Tw T* (10%\) \023\024)Tj /Span<>> BDC ( )Tj EMC 3.527 0 Td [(\023\036\030\r\017\004\027\024\005 )0.5(\021\024\004\022\036 \023\030\017)]TJ /Span<>> BDC ( )Tj EMC 8.856 0 Td [(\023\030\024\n\036\032\031\021\024\004\027\024\n )0.5(\026\031\007\017\021\036, )]TJ 0.178 Tw -12.383 -1.218 Td (\002\t\035\024 \023\030\017\027\016\021\024 \030\036\001\036\027\017\036\ \026\022\024\027\004\017\021\034 \027\026\002\024\030 \023\026\006\017\ \036\027\021\024\r )Tj 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\024\f\021\026\027\024\r\017\021\034 \017\f\f\035\036\007\024\r\026\027\017\ \036 \007\024\f\030\024\004\027\024.)Tj 0.554 Tw T* (\215\030\024\021\024\022\024\035 \030\026\027\007\024\n\017\017\030\024\ \r\026\027\027\024\020\024 \022\035\017\027\017\004\036\f\022\024\020\024\ \017\f)Tj 0 Tw (-)Tj 0.474 Tw T* (\f\035\036\007\024\r\026\027\017\016 \030\026\f\f\n\024\021\030\036\027 \ \017)Tj /Span<>> BDC ( )Tj EMC (\031\021\r\036\030\032\007\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\f\036\007\026)Tj 0 Tw (-)Tj 0.261 Tw T* (\027\017\017 \035\024\022\026\035\034\027\024\020\024 \220\021\017\004\036\ \f\022\024\020\024 \022\024\n\017\021\036\021\026 \205\206\207\211 \253\203\ \204\230\037 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 19.9527 56.0378 Tm (118)Tj ET endstream endobj 846 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-10(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ \026)11(\004\005\017\224\n\n \b\022\020\004\225\004\t\n\n \005\017\r\017 )]TJ 0 -1 TD [(\224\005\213\024\025\221 \r\n\204\r\n: \005\004\212)21(\002\020\200)21.1(\026)11(\017\026\217 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 42.014 1 Td [(Ef)-31(f)-21(icacy of\022total neoadju)10(v)10(ant th)11(er)21.1(apy for r)31(ectal )]TJ 4.252 -1 Td [(cancer: r)31.1(esults of\022a\022r)21(andomiz)10(ed trial)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 440.8534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 440.8534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 413.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 413.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 359.1763 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.014 Tw 9 0 0 9 90.7087 730.4919 Tm [(AIM: )0.6(to )0.6(com)16(pare )0.6(the )0.6(treatment )0.6(outcomes )0.6(of )0.5(rectal )0.7(cancer )0.6(patients )0.6(using )0.6(tw)12(o )0.6(regimens )0.6(of )0.6(to)13(tal )0.6(neoadjuv)16(ant )0.6(therap)12(y )]TJ 0.158 Tw 0 -1.111 TD [(\(TNT\): )0.6(shor)-40(t-course )0.7(radio)13(therap)12(y )0.6(with )0.5(three )0.6(cycles )0.6(of )0.5(consolid)26.1(ating )0.6(chemo)13(therap)12(y )0.5(and )0.5(long-course )0.6(chemoradio)]TJ 0 Tw (-)Tj 0.023 Tw T* [(therap)12(y with three cycles of consolid)26.1(ating chemo)13(therap)12.1(y)32(.)]TJ 0.056 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a p)46(rospectiv)13(e, Sing)13(le-Center)61.1(, R)20(andomized S)28(tudy)32.1(. F)27(rom Sep)13(tember 2022 to F)11(ebruar)-43(y 2025, )]TJ 0.119 Tw T* [(125 patients w)12(ere enrolled in the study)32(. Of these, 64 w)12(ere assigned to Group A and 61 to Group B. In Group A)12(, )]TJ 0.026 Tw 0 -1.111 TD [(patients receiv)13.1(ed a shor)-39.9(t-course radio)13(therap)12(y \(RT\) regimen follow)12.1(ed by three cycles of consolid)26(ating chemo)13(therap)12(y )]TJ 0.093 Tw 0 -1.111 TD [(with )0.5(the )0.5(XELO)20(X )0.5(regimen. )0.5(T)56(reatment )0.6(response )0.5(w)13(as )0.5(assessed )0.5(10\23118)]TJ /Span<>> BDC ( )Tj EMC [(w)12(eek)-22.9(s af)-45.9(ter )0.5(the )0.5(com)16(pletion )0.5(of )0.5(radio)13(therap)12(y)32(. )0.5(In )]TJ 0.061 Tw T* [(Group B, patients receiv)13(ed a long-course chemoradio)13.1(therap)12(y \(CRT\) regimen follow)12(ed by three cycles of consolid)26(at)]TJ 0 Tw (-)Tj 0.125 Tw T* [(ing chemo)13(therap)12.1(y with the XELO)20.1(X regimen. T)56(reatment response w)13(as assessed 10\23118)]TJ /Span<>> BDC ( )Tj EMC [(w)12(eek)-23(s af)-46(ter the com)16(pletion )]TJ 0.138 Tw T* [(of )0.5(chemoradio)13.1(therap)12(y)32(. )0.5(The )0.5(p)46(r)-37(imar)-43(y )0.5(endpoint )0.5(of )0.5(the )0.5(study )0.5(is the )0.5(rate )0.5(of )0.5(com)16(plete tumor response \(pathological )]TJ 0.023 Tw T* [(com)16(plete response, pCR\).)]TJ 0.061 Tw T* [(RESUL)30(T)-10(S: the median tumor size w)13(as 50 mm \(interq)14.1(uar)-40(tile rang)12(e, IQR: 24\231123 mm\) in Group A and 47 mm \(IQR: )]TJ -0.03 Tw T* (27\23176 mm\) in Group B \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.3\). There w)12(ere no signif)-42.9(icant dif)-40(ferences in the p)46(resence or absence of in)11(v)13(olv)13(ed circular )]TJ -0.034 Tw T* [(resection )0.6(margin )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 7.786 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.698 0 Td [(0.9\) )0.5(or )0.6(e)-15(xtramural )0.5(v)16(ascular )0.6(in)11(v)16(asion )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 15.282 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.698 0 Td [(0.8\) )0.5(before )0.5(treatment )0.5(initiation. )0.6(Bo)13(th )0.5(g)14(roups )0.6(show)12(ed )]TJ 0.047 Tw -24.465 -1.111 Td [(com)16(parable results in ter)-14(ms of com)16(pliance \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.0\), tolerability \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.7\), and to)14(xicity \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\) of radio)13(therap)12(y)32(. )]TJ 0.068 Tw T* [(N)17(o statistically signif)-42.9(icant dif)-39.9(ferences w)12(ere found in the com)16(pliance \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1.0\), tolerability \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\), and to)14(xicity )]TJ -0.03 Tw T* (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.2\) of chemo)13(therap)12.1(y)32(. Surgical outcomes w)12(ere also com)16.1(parable reg)12(arding the rate of neg)12(ativ)12.9(e resection margins )]TJ -0.033 Tw T* (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.0\), q)14(uality of mesorectal e)-15(xcision \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.5\), deg)14(ree of tumor response to neoadjuv)16(ant treatment \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.6\), and )Tj 0.071 Tw T* [(postoperativ)13.1(e com)16(plications \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.8\). The rate of com)16.1(plete tumor responses \(bo)13(th clinical and pathological\) did )]TJ -0.001 Tw T* [(no)13(t )0.6(dif)-40(fer )0.6(signif)-43(icantly )0.6(betw)12.1(een )0.5(the )0.6(g)13.9(roups. )0.7(With )0.5(a )0.6(follow-up )0.6(ranging )0.6(from )0.6(3 )0.5(to )0.6(35 )0.5(months )0.5(\(median )0.5(18 )0.6(months\), )0.6(the )]TJ 0.022 Tw T* [(clinical com)16.1(plete response rate w)13(as 5/61)]TJ /Span<>> BDC ( )Tj EMC (\(8.2%\) in Group A and 11/64 \(17.2%\) in Group B \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.18\). The)Tj /Span<>> BDC ( )Tj EMC (patho)Tj 0 Tw (-)Tj 0.11 Tw T* [(logical com)16(plete response rate w)13(as 9/53 \(14.7%\) vs. 6/51)]TJ /Span<>> BDC ( )Tj EMC [(\(9.3%\), respectiv)13(ely \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.6\). The ov)13(erall com)16(plete )]TJ -0.019 Tw T* [(response rate w)13(as 14/61)]TJ /Span<>> BDC ( )Tj EMC [(\(22.9%\) in the shor)-40(t-course RT and 17/64 \(26.5%\) in the long-course CRT g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.6\).)Tj 0.03 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: the com)16(pared TNT regimens are com)16.1(parable in com)16(pliance, tolerability)42(, and to)14(xicity)32(. The combination )]TJ 0.127 Tw 0 -1.111 TD [(of SCRT with consolid)26(ation chemo)13(therap)12.1(y in a neoadjuv)16(ant regimen is com)16(parable in the freq)14(uency of com)16(plete )]TJ 0.023 Tw T* [(responses com)16(pared with a CRT with consolid)26(ation chemo)13(therap)12(y)32.1(.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 465.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( to)13(tal neoadjuv)16.1(ant therap)12.1(y)14(; rectal cancer; TNT)82(; locally adv)16.1(anced rectal cancer)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.076 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.5(C)-17.4(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.085 Tw 6.52 0 Td [( )0.5(F)-6.5(a)-14.9(y)-34(z)-12.1(u)-8.4(l)-16.7(i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC 4.289 0 Td [(R)-21.4(.)-9.8(I)-10.3(.)-23.5(, )0.5(A)-11.7(l)-23.6(e)-16.2(k)-39.6(s)-22.9(e)-25.1(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 6.372 0 Td [(M)-7.1(.)40.6(V)39.7(.)-23.5(, )0.5(R)-30.3(y)-19.6(b)-17.7(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.271 0 Td [(E)-5.6(.)15(G)-11.6(.)-23.5(, )0.5(B)-16.4(a)-11.4(l)-33(k)-24.3(a)-10.1(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.362 0 Td [(A)-23(.)-23.9(A)-23(. )0.5(Ef)-62.5(f)-63(i)-5(c)-21.5(a)-11.1(c)-42.4(y )0.5(o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC 7.321 0 Td [(t)-21.9(o)-15.8(t)-36.8(a)-11.4(l )0.5(n)-16.1(e)-21(o)-18.2(a)-13(d)-16.3(j)-3.5(u)-14.9(v)-28.4(a)-7.6(n)-17.3(t )0.5(t)-26.1(h)-15.1(e)-12.1(r)-30.8(a)-8.7(p)-19.7(y )0.5(f)-25.1(o)-11.8(r )0.5(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l )0.5(c)-21.5(a)-7.6(n)-10(c)-9.7(e)-12.1(r)-24.7(:)23( )]TJ 0.011 Tc -0.035 Tw -37.14 -1.2 Td [(r)-19.1(e)-22.8(s)-8.8(u)-8.4(l)-15.3(t)-48.9(s o)-12(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(r)-30.8(a)-7.6(n)-14.5(d)-11.1(o)-9.2(m)-14.5(i)-8.3(z)-13.9(e)-21(d t)-30.7(r)-56.4(i)-5.1(a)-11.4(l)-31.7(. )]TJ /T1_1 1 Tf 0.021 Tc -0.021 Tw [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.7(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.011 Tc -0.035 Tw 19.177 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)29.8(1)12.6(6)-25.9(\226)50.8(12)8.8(4)-0.9(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.4(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.8(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.2(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.1(1)26.9(-)55.2(1)29.8(1)12.6(6)-26.7(-)55.1(12)8.8(4)]TJ /T1_2 1 Tf 0.01 Tc 0.07 Tw -19.172 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.075 Tw 10.681 0 Td ( \214\020\235\016\r\f\022\025 \206.\002., \214\216\221\210 \253\001\215\002\ \037 \n\031\f\031\033\032\031\n\023\031\f\031\b\022\022 \022\026\027\025\ \022 \003.\001.)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 \003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, )Tj 0.023 Tw -10.686 -1.2 Td (\024\023\032.)Tj /Span<>> BDC ( )Tj EMC (28, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: faiz\ ulin_ri@gnck.ru)Tj /T1_2 1 Tf 0.01 Tc 0.024 Tw 0.005 -1.2 Td [(ADDRESS)5( )0.5(F)12.9(OR)4.9( )0.6(C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.029 Tw 14.062 0 Td [( )0.5(F)15(ayzulin )0.6(R.I., )0.5(Ryzhikh )0.6(N)18(ational )0.6(Medical )0.6(R)20.9(esearch )0.5(Center )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 23.353 0 Td [(Colop)46(roctology )0.6(Salyama )0.5(Adilya )0.6(st., )0.5(2/28, )0.5(Moscow)52.1(, )]TJ 0.023 Tw -37.42 -1.2 Td [(123423, R)22(ussia; e-mail: faizulin_r)-37(i@gnck.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 17.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 17.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 298.5999 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.255 Tw 10 0 0 10 42.5197 274.2439 Tm (\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\021\026\027\007\ \026\030\021\024\n \035\036\004\036\027\017\016 \n\036\f\021\027\024\030\ \026)Tj 0 Tw (-)Tj 0.154 Tw 0 -1.218 TD (\f\023\030\024\f\021\030\026\027\036\027\027\024\020\024 \030\026\022\026\ \023\030\016\n\024\005 \022\017\001\022\017 \016\r\035\016\036\021\f\016\ \023\030\024)Tj 0 Tw (-)Tj 0.604 Tw T* (\r\036\007\036\027\017\036 \027\036\024\026\007\255\033\r\026\027\021\027\ \024\005 \b\017\n\017\024\035\031\004\036\r\024\005 \021\036\030\026\023\ \017\017 )Tj 0.365 Tw T* (\(\216\214\221\), \022\024\021\024\030\026\016 \023\024\r\024\035\016\036\ \021 \031\n\036\027\034\001\017\021\034 \030\026\n\036\030 \023\036\030\ )Tj 0 Tw (-)Tj 0.327 Tw T* (\r\017\004\027\024\005 \024\023\031\b\024\035\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \f\027\017\032\026\036\021 \030\017\f\022 \030\036\006\ \017\007\017\r\026 )Tj 0 Tw T* (\026\002\024\035\036\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC ([1].)Tj 0.501 Tw T* (\203\024\r\t\n \220\021\026\023\024\n \030\026\r\017\021\017\016 \027\036\ \024\026\007\255\033\r\026\021\027\024\005 \021\036\030\026\023\017\017 \ )Tj 0.562 Tw T* [(\f\021\026\035\026 \021\024\021\026\035\034\027\026\016 \027\036\024\026\ \007\255\033\r\026\027\021\027\026\016 )0.5(\021\036\030\026\023\017\016 \(\221\203\221\), )]TJ 0.321 Tw T* (\r\022\035\033\004\026\033\013\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\036\002\016 \023\030\024\r\036\007\036\027\017\036 \022\026\022 \035\031\ \004\036\r\024\005, \021\026\022 )Tj 0.041 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\n\017\024\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\027\021\027\024\n \030\036\032\017\n\036\ . \200\026\032\027\t\n )Tj 0.357 Tw T* (\023\030\036\017\n\031\013\036\f\021\r\024\n \221\203\221 \016\r\035\016\ \036\021\f\016 \031\r\036\035\017\004\036\027\017\036 \004\026\f\021\024\ \021\t )Tj 0.349 Tw T* (\023\024\035\027\t\b \024\021\r\036\021\024\r \024\023\031\b\024\035\017\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\026\007\255\033\r\026\021\027\024\036 \035\036\004\036)Tj 0 Tw (-)Tj 0.406 Tw T* [(\027\017\036 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\f\030\026\r\027\036\027\017\017 )0.5(\f\024 \f\021\026\027\007\026\030\021\027\t\n )0.5(\030\036\032\017\n\024\n )0.5(\023\030\024)]TJ 0 Tw (-)Tj 0.193 Tw T* [(\035\024\027\020\017\030\024\r\026\027\027\024\005 )0.6(\b\017\n\017\024\035\031\004\036\r\024\005 )0.5(\021\036\030\026\023\017\017. )0.6(\221\026\022, )0.5(K)-16(asi)]TJ /Span<>> BDC ( )Tj EMC 21.26 0 Td (A. )Tj 0.207 Tw -21.26 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \r)Tj /Span<>> BDC ( )Tj EMC (2020 \020. \023\030\024\r\036\035\017 \n\036\021\026\026\027\026\035\017\  \022\026\022 \030\026\027\007\024)Tj 0 Tw (-)Tj 0.232 Tw T* (\n\017\017\030\024\r\026\027\027\t\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\036\030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b )0.5(\017\f\f\035\036)]TJ 0 Tw (-)Tj 0.28 Tw T* [(\007\024\r\026\027\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\021\024\030\024\n \023\024\022\026\026\035\017, )0.5(\004\021\024 \004\026\f\021\024\021\026 )0.5(\023\024\035\027\t\b )]TJ 0.074 Tw 23.244 21.92 Td (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021\r\036\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\032\017\n\036 \221\203\221 \f\021\026\021\017\f)Tj 0 Tw (-)Tj -0.042 Tw T* [(\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\024 \r\t\001\036, )0.5(\004\036\n \r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\032\017\n\036 )0.5(\023\030\024\035\024\027\020\017\030\024\r\026\027)]TJ 0 Tw (-)Tj 0.141 Tw T* (\027\024\005 \216\214\221 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\036\021 29,9% \023\030\024\021\017\r 14,9%, \f\ \024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\036\027\027\024 \(\210\231 2,44; 95% \212\230 1,99\2265,98;p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\))Tj /Span<>> BDC ( )Tj EMC ([2].)Tj 0.447 Tw T* [(\200\026\032\027\024 )0.6(\023\024\007\004\036\030\022\027\031\021\034, )0.5(\004\021\024 )0.6(\221\203\221 )0.5(\n\024\032\036\021 )0.5(\023\030\024\r\024\007\017\021\034\f\016 )]TJ 0.086 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \022\026\022 \017\027\007\031\022\ \006\017\024\027\027\024\005, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017)Tj 0 Tw (-)Tj 0.327 Tw T* (\030\031\033\013\036\005 \b\017\n\017\024\021\036\030\026\023\017\017. \200\ )Tj /Span<>> BDC ( )Tj EMC (\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\n \017\f)Tj 0 Tw (-)Tj 0.433 Tw T* [(\f\035\036\007\024\r\026\027\017\017 C)20(A)15(O/ARO/AIO-12 \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\027\ \024, )]TJ 0.3 Tw T* (\004\021\024 \023\030\036\007\023\024\004\021\017\021\036\035\034\027\t\n\ \007\035\016 \r\024\027\017\022\027\024\r\036\027\017\016 \023\024\035\ \027\t\b )Tj -0.036 Tw T* (\023\026\021\024\n\024\030\235\024\035\024\020\017\004\036\f\022\017\b \024\ \021\r\036\021\024\r \024\023\031\b\024\035\017 \016\r\035\016\036\021\f\ \016 \023\030\017)Tj 0 Tw (-)Tj 0.097 Tw T* (\n\036\027\036\027\017\036 \022\024\027\f\024\035\017\007\017\030\031\033\ \013\036\005 \b\017\n\017\024\021\036\030\026\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj -0.011 Tw T* (\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\024\027\027\024\005. \200)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017 \004\026\ \f\021\024\021\026 )Tj 0.26 Tw T* (\023\024\035\027\t\b \023\026\021\024\n\024\030\235\024\035\024\020\017\004\ \036\f\022\017\b \024\021\r\036\021\024\r \024\023\031\b\024\035\017 \f\024\ )Tj 0 Tw (-)Tj -0.046 Tw T* (\f\021\026\r\017\035\026 25% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221 \f)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\f\024\035\017\007\017\030\031\033\013\036\005 \b\017\n\017\024\ )Tj /Span<>> BDC (-)Tj EMC 0.115 Tw T* (\021\036\030\026\023\017\036\005 \023\030\024\021\017\r 17% \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \221\203\221 \f)Tj /Span<>> BDC ( )Tj EMC (\017\027\007\031\022\006\017\024\027\027\024\005 )Tj 0.044 Tw T* (\b\017\n\017\024\021\036\030\026\023\017\036\005 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_3 1 Tf 0.044 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) [3]. \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034\ , \004\021\024 )Tj 0.065 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \023\026\006\017\036\027\021\ \026\n \023\030\024\r\024\007\017\035\f\016 \023\030\024\035\024\027\020\ \017\030\024)Tj 0 Tw (-)Tj 0.19 Tw T* [(\r\026\027\027\t\005 )0.5(\022\031\030\f \216\214\221 )0.5(\f\031\n\n\026\030\027\024\005 \024\004\026\020\024\r\024\005 )0.5(\007\024\024\005 )0.5(\(\222\210\212\) )]TJ 0 Tw T* (50,4 \206\030.)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 738.9961 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 730.0688 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.7145 56.0378 Tm (117)Tj ET endstream endobj 843 0 obj [852 0 R] endobj 844 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 259.0103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 259.0103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 221.8025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 221.8025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-116-124)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 125.5518 695.3259 Tm [(\211\216\216\004\r)-10(\026\n\b\t\025\016)-9.9(\026\200 \026)11(\025\026)11(\017\020\200\t\025\221 \t\004\025\017\202\241\206\b\017\t\026\t\025\221 \ )]TJ -1.595 -1.105 Td [(\026)11(\004\005\017\224\n\n \b\022)-23.2(\020\004\225\004\t\n\n \005\017\r\017 \224\005\213\024\025\221 \r\n\204\r\ \n: \005\004\212)21.1(\002\020\200)21(\026)11(\017\026\217 )]TJ 3.159 -1.105 Td [(\005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10.1(\025 \n\016\016)-10(\020\004\202\025\b\017\t\n\213)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 628.822 Tm [(\210\017\221\212)21(\002\020\n\t\022)-23.2(\033)124(.\030.)]TJ 8.162 0 0 8.162 155.8351 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 160.4711 628.822 Tm [(, \f)-21(\020\004\r\016\004\004\b\022)-23.2(\235.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 253.0316 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 264.3522 628.822 Tm [(, \033\217\255\017\r)10(\025\b\022)-23.2(\240.\031)72(.)]TJ 0 Tw 8.162 0 0 8.162 344.3835 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 349.0195 628.822 Tm [(, \006\017\020\r\017\005\025\b\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 442.966 633.484 Tm (1)Tj 5.83 0 0 5.83 70.8661 614.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 611.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n\022)-23.3(\f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \016)-10(\026\005)-31(.\022)-23.3(2)35(8, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\235\025\016\r\b\017, 1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 590.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 587.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_0 1 Tf -0.022 Tw 9 0 0 9 119.0551 568.6488 Tm (\037\036\035\034: \024\032\020\021\025\022\023\017 \032\027\016\r\f\017\023\ \020\023\013 \f\027\007\027\025\022\t \240\031\f\017\025\013\200 \032\020\ \n\031\026 \033\032\t\026\031\235 \n\022\213\n\022 \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\022\026\027\025\027\025\022\027\026 \030\021\r\200 \032\027\255\ \022\026\031\021 \023\031\023\020\f\017\025\031\235 )Tj 0.04 Tw 0 -1.111 TD [(\025\027\031\020\030\236\005\021\020\025\023\025\031\235 )0.6(\023\027\032\020\033\022\022 )0.5(\(\001\): )0.5(\n\031\032\031\023\n\031\b\031 )0.5(\n\r\032\024\020 )0.5(\f\r\007\027\021\031\235 )0.5(\023\027\032\020\033\022\022 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\023\032\027\026\t \n\r\032\024\020\026\022 )0.5(\n\031\025\024\031\f\022\030\022\032\r\005\212\027\235 \200\022)]TJ 0 Tw (-)Tj -0.005 Tw T* (\026\022\031\023\027\032\020\033\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\f\031\025\b\022\032\031\021\020\025\025\031\235 \200\022\026\ \022\031\f\r\007\027\021\031\235 \023\027\032\020\033\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\023\032\027\026\t \n\r\032\024\020\026\022 \n\031\025\024\031\f\022\030\ \022\032\r\005\212\027\235 \200\022\026\022\031\023\027\032\020\033\022\022\ .)Tj 0.004 Tw T* (\004\003\037\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \024)Tj /Span<>> BDC ( )Tj EMC 9.557 0 Td [(\024\027\025\023\t\240\032\t )0.5(2022 \033\031)]TJ /Span<>> BDC ( )Tj EMC [(\203\027\021\032\020\f\017 )0.5(2025 \b\b. )0.5(\033\032\031\021\027\030\027\025\031 \033\032\031\024\033\027\n\023\022\021\ \025\031\027 \031\030\025\031\006\027\025\023\032\031\021\031\027 \032\020\ \025\030\031)]TJ 0 Tw (-)Tj 0.062 Tw -9.557 -1.111 Td (\026\022\016\022\032\031\021\020\025\025\031\027 \022\024\024\f\027\030\031\ \021\020\025\022\027. \211)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\021\031\030\022\f\024\t \n\031\032\031\023\n\022\235 \n\r\032\ \024 \f\r\007\027\021\031\235 \023\027\032\020\033\022\022 \(\035\) \024\ )Tj /Span<>> BDC ( )Tj EMC (\023\032\027\026\t \n\r\032\024\020\026\022 )Tj -0.022 Tw 0 -1.111 TD (\n\031\025\024\031\f\022\030\022\032\r\005\212\027\235 \200\022\026\022\031\ \023\027\032\020\033\022\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\024\200\027\026\027 XELOX \024)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\031\235 \204\203\203\027\n\023\020 \007\027\032\027\016\ 10\23118)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\f\017 \033\031\024\f\027 \031\n\031\025\007\020\025\022\ \t \035. )Tj 0.045 Tw 0 -1.111 TD (\211)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221 \033\032\031\021\031\030\022\f\024\t \033\032\031\ \f\031\025\b\022\032\031\021\020\025\025\013\235 \n\r\032\024 \200\022\026\ \022\031\f\r\007\027\021\031\235 \023\027\032\020\033\022\022 \(\225\035\ \) \024)Tj /Span<>> BDC ( )Tj EMC (\023\032\027\026\t \n\r\032\024\020\026\022 \n\031\025\024\031\f\022\030\ \022\032\r)Tj 0 Tw (-)Tj 0.059 Tw T* (\005\212\027\235 \200\022\026\022\031\023\027\032\020\033\022\022 \033\031\ )Tj /Span<>> BDC ( )Tj EMC (\024\200\027\026\027 XELOX \024)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\031\235 \204\203\203\027\n\023\020 \007\027\032\027\016\ 10\23118)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\f\017 \033\031\024\f\027 \031\n\031\025\007\020\025\022\ \t \225\035. \207\020)Tj /Span<>> BDC ( )Tj EMC (\031\240\031\016)Tj /Span<>> BDC (-)Tj EMC 0.043 Tw T* (\025\020\007\027\025\025\013\235 \033\027\032\022\031\030 \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027 \021\n\f\005\007\027\025\031\ 125 \007\027\f\031\021\027\n, \022\016)Tj /Span<>> BDC ( )Tj EMC (\025\022\200 64 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\022 61)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221. \004\027\032\021\022\007\025\020\t )Tj 0.023 Tw T* (\023\031\007\n\020 \022\024\024\f\027\030\031\021\020\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 \007\020\024\023\031\023\020 \033\031\f\025\013\200 \031\023\021\027\ \023\031\021 \031\033\r\200\031\f\022.)Tj 0.173 Tw T* (\206\036\207\210\035\034\003\201: \026\027\030\022\020\025\020 \032\020\ \016\026\027\032\020 \031\033\r\200\031\f\022 \024\031\024\023\020\021\022\ \f\020 50 \(\022\025\023\027\032\n\021\020\032\023\022\f\017\025\013\235\ \032\020\016\026\020\200 \(IQR\): 24\231123\) \026\026)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.099 Tw T* (\021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\022 47 \(IQR: 27\23176\) \026\026)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,3\), \025\027 \240\013\f\031 \032\020\016\f\022\007\022\235 \033\031)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\005 \022\f\022 \031\023\024\r\023\024\023\021\022\ \005 )Tj 0.019 Tw T* (\021\031\021\f\027\007\027\025\022\t \006\022\032\n\r\f\t\032\025\031\b\031\ \n\032\020\t \032\027\016\027\n\006\022\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,9\) \022\f\022 \022\025\021\020\016\022\022 \204\n\024\023\032\020\026\ \r\032\020\f\017\025\013\200 \024\031\024\r\030\031\021 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\) \030\031)Tj /Span<>> BDC ( )Tj EMC (\025\020\007\020\f\020 )Tj 0.157 Tw T* (\f\027\007\027\025\022\t. \211)Tj /Span<>> BDC ( )Tj EMC [(\031\240\027\022\200 \b\032\r\033\033\020\200 \033\031\f\r\007\027\025\013\ \024\031\033\031\024\023\020\021\022\026\013\027 )0.5(\032\027\016\r\f\017\023\020\023\013 \033\031)]TJ /Span<>> BDC ( )Tj EMC (\n\031\026\033\f\020\027\025\023\025\031\024\023\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\), \033\027\032\027\025\031\024\022)Tj 0 Tw (-)Tj 0.102 Tw 0 -1.111 TD (\026\031\024\023\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7\) \022)Tj /Span<>> BDC ( )Tj EMC (\023\031\n\024\022\007\025\031\024\023\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\) \f\r\007\027\021\031\235 \023\027\032\020\033\022\022. \020\n\255\ \027 \025\027 \021\013\t\021\f\027\025\031 \024\023\020\023\022\024\023\022\ \007\027\024\n\022 \016\025\020\007\022\026\013\200 )Tj 0.09 Tw 0 -1.111 TD [(\032\020\016\f\022\007\022\235 )0.6(\033\031)]TJ /Span<>> BDC ( )Tj EMC 5.425 0 Td [(\n\031\026\033\f\020\027\025\023\025\031\024\023\022 )0.7(\(\032)]TJ /Span<>> BDC ( )Tj EMC 8.78 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.822 0 Td [(1,0\), )0.6(\033\027\032\027\025\031\024\022\026\031\024\023\022 )0.6(\(\032)]TJ /Span<>> BDC ( )Tj EMC 10.111 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.822 0 Td [(0,8\) )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 2.775 0 Td [(\023\031\n\024\022\007\025\031\024\023\022 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 7.155 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.822 0 Td [(0,2\) )0.5(\200\022\026\022\031\023\027\032\020\033\022\022. )]TJ 0.075 Tw -36.713 -1.111 Td (\205\031\033\031\024\023\020\021\022\026\013 \031\n\020\016\020\f\022\024\ \017 \022)Tj /Span<>> BDC ( )Tj EMC (\032\027\016\r\f\017\023\020\023\013 \200\022\032\r\032\b\022\007\027\024\ \n\031\b\031 \f\027\007\027\025\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (\007\020\024\023\031\023\027 \031\023\032\022\006\020\023\027\f\017\025\013\ \200 \b\032\020\025\022\006 \032\027\016\027\n)Tj 0 Tw (-)Tj -0.014 Tw T* (\006\022\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,0\), \n\020\007\027\024\023\021\r \026\027\016\031\032\027\n\023\r\026\ \204\n\023\031\026\022\022 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,5\), \024\023\027\033\027\025\022 \031\023\021\027\023\020 \031\033\r\200\ \031\f\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\020\030\236\005\021\020\025\023\025\031\027 \f\027\007\027\025\ \022\027 )Tj 0.003 Tw T* (\(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\) \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\013\026 \031\024\ \f\031\255\025\027\025\022\t\026 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,8\). \232\020\024\023\031\023\020 \033\031\f\025\013\200 \031\023\021\027\ \023\031\021 \031\033\r\200\031\f\022 \(\n\020\n \n\f\022\025\022\007\027\ \024\n\022\200, )Tj 0.13 Tw T* (\023\020\n \022)Tj /Span<>> BDC ( )Tj EMC (\033\020\023\031\026\031\032\203\031\f\031\b\022\007\027\024\n\022\200\)\ \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\ \026\031 \025\027 \032\020\016\f\022\007\020\f\020\024\017 \021)Tj /Span<>> BDC ( )Tj EMC (\031\240\027\022\200 \b\032\r\033\033\020\200: \007\020\024\023\031\023\020\ \033\031\f\025\013\200 )Tj 0.118 Tw T* (\n\f\022\025\022\007\027\024\n\022\200 \031\023\021\027\023\031\021 \033\ \032\022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\024\f\027\255\027\025\025\031\024\023\022 \031\023 3 \030\031\ )Tj /Span<>> BDC ( )Tj EMC (35 \026\027\024\t\006\027\021 \024)Tj /Span<>> BDC ( )Tj EMC (\026\027\030\022\020\025\031\235 \021)Tj /Span<>> BDC ( )Tj EMC (18 \026\027\024\t\006\027\021 \024\031\024\023\020\021\022\f\020 5/61 )Tj -0.017 Tw T* (\(8,2%\) \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \003)Tj /Span<>> BDC ( )Tj EMC (\022 11/64 \(17,2%\))Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \221 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\). \232\020\024\023\031\023\020 \033\031\f\025\013\200 \033\020\023\ \031\026\031\032\203\031\f\031\b\022\007\027\024\n\022\200 \031\023\021\027\ \023\031\021 )Tj 0.042 Tw T* (\024\031\024\023\020\021\022\f\020 9/53 \(14,7%\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\031\023\022\021 6/51 \(9,3%\), \024\031\031\023\021\027\023\ \024\023\021\027\025\025\031 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\). \217\240\212\020\t \007\020\024\023\031\023\020 \033\031\f\025\013\ \200 \031\023\021\027)Tj 0 Tw (-)Tj -0.026 Tw 0 -1.111 TD (\023\031\021)Tj /Span<>> BDC ( )Tj EMC (\227 14/61 \(22,9%\) \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \n\031\032\031\023\n\031\b\031 \n\r\032\024\020 \035\  \022)Tj /Span<>> BDC ( )Tj EMC (17/64 \(26,5%\) \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \033\032\031\f\031\025\b\022\032\031\021\020\025\025\ \031\235 \225\035 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,6\).)Tj 0.139 Tw 0 -1.111 TD (\207\003\202\035\224\232\036\001\002\036: \024\032\020\021\025\022\021\020\ \027\026\013\027 \032\027\255\022\026\013 \001 \024\031\033\031\024\023\ \020\021\022\026\013 \033\031)Tj /Span<>> BDC ( )Tj EMC (\n\031\026\033\f\020\027\025\023\025\031\024\023\022, \033\027\032\027\025\ \031\024\022\026\031\024\023\022 \022)Tj /Span<>> BDC ( )Tj EMC (\023\031\n\024\022\007\025\031)Tj 0 Tw (-)Tj 0.027 Tw T* (\024\023\022. \202\031\026\240\022\025\020\006\022\t \n\031\032\031\023\n\ \031\b\031 \035 \024)Tj /Span<>> BDC ( )Tj EMC (\n\r\032\024\031\026 \n\031\025\024\031\f\022\030\022\032\r\005\212\027\235\ \200\022\026\022\031\023\027\032\020\033\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\020\030\236\005\021\020\025\023\025\031\026 \032\027\255\022\ \026\027 \024\031\033\031)Tj 0 Tw (-)Tj 0.053 Tw T* (\024\023\020\021\022\026\020 \033\031)Tj /Span<>> BDC ( )Tj EMC [(\007\020\024\023\031\023\027 \033\031\f\025\013\200 \031\023\021\027\023\ \031\021 )0.5(\031\033\r\200\031\f\022 \033\032\t\026\031\235 \n\022\213\n\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\027\025\022\022 \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\f\031\025\b\022\032\031\021\020\025\025\013\026 \n\r\032\024\ \031\026 \225\035 )Tj 0.023 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\n\r\032\024\031\026 \n\031\025\024\031\f\022\030\022\032\r\005\212\027\235\ \200\022\026\022\031\023\027\032\020\033\022\022.)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 8 0 0 8 70.9061 283.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 8.493 0 Td ( \023\031\023\020\f\017\025\020\t \025\027\031\020\030\236\005\021\020\025\ \023\025\020\t \023\027\032\020\033\022\t; \032\020\n \033\032\t\026\031\ \235 \n\022\213\n\022; \001; \026\027\024\023\025\031\032\020\024\033\032\ \031\024\023\032\020\025\027\025\025\013\235 \032\020\n \033\032\t\026\031\ \235 \n\022\213\n\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw -8.493 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.033 Tc 0.009 Tw -10.401 -2.617 Td [(\020\036\017)4.7( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.023 Tc 0.014 Tw 9.181 0 Td ( \205\026\005\031\035\017\027)Tj /Span<>> BDC ( )Tj EMC (\217.\230., \202\035\036\022\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\200., \217\t\002\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\206., \207\026\035\022\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202. \233\235\235\036\022\021\017\r\027\024\f\021\034 \021\024\021\ \026\035\034\027\024\005 \027\036\024\026\007\255\033\r\026\027\021\027\024\ \005 \021\036\030\026)Tj 0 Tc 0 Tw (-)Tj 0.022 Tc -0.035 Tw -9.186 -1.2 Td (\023\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\035\036\004\036\027\017\017 \030\026\022\026 \023\030\016\n\024\005 \022\ \017\001\022\017: \030\036\031\035\034\021\026\021\t \030\026\027\007\024\ \n\017\017\030\024\r\026\027\027\024\020\024 \017\f\f\035\036\007\024\r\ \026\027\017\016. )Tj /T1_0 1 Tf -0.022 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.035 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC [(116\226124.)22( )]TJ 0.023 Tc -0.023 Tw 0 -1.2 TD (https://doi.org/10.33878/2073-7556-2026-25-1-116-124)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 130.2518 195.6332 Tm [(Ef)-31(f)-21(icacy of\022)-23.3(total neoadju)10(v)10(ant th)11(er)21(apy for r)31(ectal )]TJ 2.138 -1.167 Td [(cancer: r)30.9(esults of\022)-23.2(a\022)-23.3(r)21(andomiz)10(ed trial)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 150.1292 Tm [(Rashid\022)-23.2(I.\022)-23.3(F)25(ay)21(z)10(ulin)]TJ 8.162 0 0 8.162 168.6908 154.7912 Tm (1)Tj 0.023 Tw 14 0 0 14 173.3267 150.1292 Tm [(, Mikhail\022)-23.3(V)62(.\022)-23.3(Alek)11.1(see)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 291.0208 154.7912 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 302.3415 150.1292 Tm [(, Ev)10(geny\022)-23.2(G.\022)-23.3(R)20(ybak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 420.9328 154.7912 Tm (1)Tj 14 0 0 14 425.5688 150.1292 Tm (, )Tj -25.336 -1.143 Td [(Ar)-20(t)-19.9(y)21(om\022)-23.3(A)-31(.\022)-23.3(Balkar)20.1(ov)]TJ 8.162 0 0 8.162 182.2283 138.7912 Tm (1)Tj 5.83 0 0 5.83 70.8661 119.79 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 116.46 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, 2)35(8, Moscow)22(, 1)125(23)58.1(423, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj ( )Tj 5.83 0 0 5.83 70.8661 95.79 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 92.46 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1-1)69(, Moscow)22(, 1)125(2)23(5)23(99)35(3, )]TJ 0 Tw -0.331 -1.2 Td (Russia\))Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 577.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 76.0071 568.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 19.9401 56.0378 Tm (116)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 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A)-14(bd)-16(ominal injur)-36.9(ies. P)40(ar)-22(t 2 )]TJ 0.071 Tw T* [(\(cl)-31(inic, dia)-17(gnosis, tr)-24(ea)15(tment\). )]TJ /T1_2 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC (Hygiene and Epidemiology)Tj /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* (2022;26\(2\):179\226187. \(In Russ.\).)Tj 0.265 Tw T* (25.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Clemens)Tj /Span<>> BDC ( )Tj EMC [(MS, P)30(ea)-17(ce)]TJ /Span<>> BDC ( )Tj EMC [(KM, Y)-28.9(i)]TJ /Span<>> BDC ( )Tj EMC [(F. R)13(ec)-16(t)15(al T)50(r)-32.9(auma: Ev)-16(idence-Based )]TJ 0.009 Tc -0.009 Tw -1.796 -1.25 Td [(P)34.6(r)-33.3(a)-17.4(c)-16.3(t)-32.4(ices. )]TJ /T1_2 1 Tf 0.352 Tw 4.696 0 Td [(Clinics in Colon and R)20.6(ectal Surg)11.6(er)-43.4(y)]TJ /T1_1 1 Tf [(. 2018;31:17\22623.)9( )]TJ 0 Tc 0 Tw -4.696 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1055/s-0037-1602182)Tj 0 0 0 1 k /GS1 gs 0.104 Tw -1.847 -1.25 Td (26.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bosar)-32(ge)]TJ /Span<>> BDC ( )Tj EMC (PL, Como)Tj /Span<>> BDC ( )Tj EMC [(JJ, F)10(o)14(x)]TJ /Span<>> BDC ( )Tj EMC [(N. e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(pene)-12(tr)-33(a)15(t)-32(ing )]TJ -0.067 Tw -1.796 -1.25 Td [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal r)-24(ec)-16(t)15(al injur)-37(ies: An)]TJ /Span<>> BDC ( )Tj EMC [(Easter)-14.9(n Asso)-16(c)-23.9(ia)15(t)-32(ion for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Sur)-31.9(ger)-24(y )]TJ 0.276 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(T)50(r)-33(auma p)25(r)-33(a)-17(c)-16(t)-32(ice mana)-17(gement guidel)-31(ine. )]TJ /T1_2 1 Tf [(J T)56(rauma Acute Care )]TJ 0 Tw T* (Surg.)Tj /T1_1 1 Tf 0.023 Tw [(2016;80\(3\):546\226551. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/T)35(A.0000000000000953)]TJ 0 0 0 1 k /GS1 gs 0.282 Tw T* (27.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Dild)42(a)15(y)]TJ /Span<>> BDC ( )Tj EMC [(J, O)-32(w)-12(a)15(t)-30(t)15(anap)32(anich)]TJ /Span<>> BDC ( )Tj EMC (N, Benjamin)Tj /Span<>> BDC ( )Tj EMC [(E.R., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oper)-33(a)15(t)-32(i)-15.9(ve )]TJ 0.333 Tw -1.796 -1.25 Td [(mana)-17(gement and outcomes of)]TJ /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-15.9(t)15(al injur)-36.9(ies af)-28(ter gunsho)17.1(t )]TJ 0.043 Tw T* [(w)-14(ounds in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(depl)30.1(oyed mil)-31(i)-24(t)15(ar)-23.9(y se)-12(t)-30(t)-32(ing ver)-10(sus c)-23.9(i)-16(v)-16(il)-31(ian tr)-32.9(auma cen)]TJ 0 Tw (-)Tj T* [(ter)-10(s. )]TJ /T1_2 1 Tf 0.111 Tw 2.172 0 Td [(J )0.5(T)56.1(rauma )0.5(Acute )0.6(Care )0.6(Surg.)]TJ /T1_1 1 Tf [( )0.5(2023; )0.6(95\(2S\):60\22665. )0.6(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 21.726 0 Td (10.1097/)Tj -23.899 -1.25 Td [(t)15(a.0000000000004016)]TJ 0 0 0 1 k /GS1 gs 0.013 Tc 0.465 Tw T* (28.)Tj /Span<>> BDC ( )Tj EMC 1.847 0 Td (\207\026\001\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\216., \206\030\017\027\006\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\206., \216\030\017\f\021\031\035\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0.008 Tc 0.349 Tw -1.847 -1.25 Td (\215\030\036\007\031\023\030\036\032\007\036\027\017\036 \023\024\f\035\036\ \024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tc 0 Tw (-)Tj 0.007 Tc 0.35 Tw T* (\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017 \002\024\035\034\ \027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\r\n\026\n\017 \023\030\016\n\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\024\002\024\007\024\004\027\024\005)7.1( )]TJ 0.001 Tc -0.001 Tw T* (\022\017\001\022\017. )Tj /T1_2 1 Tf 0.35 Tw 3.516 0 Td (\211\027\024\023\025\022\n \025\027\031\023\f\031\255\025\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\021\031\024\024\023\020\025\031\021\022\023\027\f\017\025\031\235 \200\022\ \032\r\032\b\022\022)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.128 Tw 25.539 80 Td [(2021;6\(1\):33\22636. / \200a)-17(cheev)]TJ /Span<>> BDC ( )Tj EMC [(V.H., )0.5(G)19.9(r)-36.9(intsov)]TJ /Span<>> BDC ( )Tj EMC [(A.G., )0.5(Khr)-37(istulenko)]TJ /Span<>> BDC ( )Tj EMC 25.753 0 Td (A.A., )Tj 0.145 Tw -25.753 -1.25 Td [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(post)17.1(oper)-33(a)15(t)-32(i)-16(ve com)10(pl)-31(ica)15(t)-31.9(ions in sur)-31.9(gical tr)-24(ea)15(t)]TJ 0 Tw (-)Tj 0.227 Tw T* (ment of)Tj /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-23.9(t)-13(h injur)-37(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-23.9(ec)-16(tum and col)30(on. )]TJ /T1_2 1 Tf 0 Tw [(Jour)-14(nal )]TJ 0.023 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(Exper)-36.9(imental and Clinical Surg)12(er)-43(y)]TJ /T1_1 1 Tf (. 2021;6\(1\):33\22636. \(In Russ.\))Tj 0.104 Tw T* (29.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Bost)-32(ick)]TJ /Span<>> BDC ( )Tj EMC [(P)35(J, Johnson)]TJ /Span<>> BDC ( )Tj EMC [(D)20(A, Hear)-24(d)]TJ /Span<>> BDC ( )Tj EMC [(JF, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-33(a)]TJ 0 Tw (-)Tj 0.023 Tw -1.796 -1.25 Td [(per)-37(i)-23.9(t)17(oneal r)-24(ec)-16(t)15(al injur)-37(ies. )]TJ /T1_2 1 Tf [(J N)18(atl Med Assoc)]TJ /T1_1 1 Tf (. 1993;85\(6\):460\226463)Tj 0.173 Tw T* (30.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\024\022\030\024\r\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\025.\202., \212\024\007\017\006\026)Tj /Span<>> BDC ( )Tj EMC (\202.\203., \200\036\f\036\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\230. \222\030\026\r\027\017\021\036\035\034\027\t\005 )Tj 0.188 Tw -1.796 -1.25 Td (\026\027\026\035\017 \030\036\031\035\034\021\026\021\024\r \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \ \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033)Tj 0 Tw (-)Tj 0.012 Tc 0.448 Tw T* [(\001\017\027\027\t\n\017 )0.6(\023\024\r\030\036\032\007\036\027\017\016\n\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017. )]TJ /T1_2 1 Tf -0.012 Tw 19.714 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_1 1 Tf 0 Tc 0 Tw (. )Tj 0.225 Tw -19.714 -1.25 Td [(2016; 55\(S1\):38\22639. / P)10(okr)-32(ovsk)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(K.A., Dodi)-24(tsa)]TJ /Span<>> BDC ( )Tj EMC [(A.N., V)30(esel)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (D.I. )Tj 0.043 Tw T* [(Com)10(p)32(ar)-33(a)15(t)-32(i)-15.9(ve anal)35(y)-13(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-23.9(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(sur)-32(gical tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(p)32.1(a)14.9(t)-31.9(ients )]TJ 0.152 Tw T* [(wi)-24(t)-12.9(h )0.5(e)-18(xtr)-33(aper)-36.9(i)-24(t)17(oneal )0.6(lesions )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 13.231 0 Td [(t)-13(he )0.5(r)-23.9(ec)-16(tum. )]TJ /T1_2 1 Tf 0 Tw 5.266 0 Td [(K)18(olop)46(roktologia)]TJ /T1_1 1 Tf 0.152 Tw [(. )0.6(2016; )]TJ 0.023 Tw -18.496 -1.25 Td (55\(S1\):38\22639. \(In Russ.\).)Tj 0.346 Tw T* (31.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\204\026\005\f\021\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC 5.484 0 Td [(\203.\202., )0.6(\222\026\024\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.441 0 Td [(\202.\202., )0.6(\217\024\n\026\013\036\027\022\024)]TJ /Span<>> BDC ( )Tj EMC 7.703 0 Td [(\215.\203., )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 3.664 0 Td (\f\024\026\r\021. )Tj 0.194 Tw -25.088 -1.25 Td (\215\030\024\235\017\035\026\022\021\017\022\026 \024\f\035\024\032\027\036\ \027\017\005 \035\026\023\026\030\024\021\024\n\027\024\005 \030\026\027\ \t \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\020\027\036\f\021\030\036\035\034)Tj 0 Tw (-)Tj 0.01 Tc 0.379 Tw T* (\027\024\005 \021\030\026\r\n\036 \032\017\r\024\021\026. )Tj /T1_2 1 Tf (\211\027\024\023\025\022\n \200\022\032\r\032\b\022\022 \022\026\027\025\ \022 \002.\002.)Tj /Span<>> BDC ( )Tj EMC (\216\032\027\n\031\021\020.)Tj /T1_1 1 Tf 0 Tc 0 Tw 27.638 0 Td ( )Tj 0.118 Tw -27.638 -1.25 Td [(2023;182\(2\):46\22652. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24884/0042-4625-2023-182-2-46-52)Tj 0 0 0 1 k /GS1 gs 0.118 Tw ( / )Tj 0.012 Tw T* [(Maistr)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC [(N.A., Sa)-24(zonov)]TJ /Span<>> BDC ( )Tj EMC [(A.A., R)11(omashchenko)]TJ /Span<>> BDC ( )Tj EMC [(P.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-24(event)-32(ion )]TJ 0.071 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-32(ions fr)-32(om t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(ap)32(ar)-32(o)17(t)17(omy w)-14(ound in abd)-16(ominal gunsho)17(t )]TJ 0 Tw T* [(injur)-23.9(y. )]TJ /T1_2 1 Tf 0.111 Tw 3.019 0 Td [(Grek)13(ov\222s Bulletin )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y)]TJ /T1_1 1 Tf (. 2023;182\(2\):46\22652. \(In Russ.\). )Tj 0 Tw -3.019 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.24884/0042-4625-2023-182-2-46-52)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.35 Tw -1.847 -1.25 Td (32.)Tj /Span<>> BDC ( )Tj EMC 1.805 0 Td (\233\005\002\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217.)Tj /Span<>> BDC ( )Tj EMC (\215\030\024\235\017\035\026\022\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\036 \023\024\007\027\017\b \f\021\024\n\026\035\ \034\027\t\b)2( )]TJ 0.006 Tc 0.349 Tw -1.805 -1.25 Td [(\024\f\035\024\032\027\036\027\017\005: \007\017\f\f. ... \022\026\027\007\ . \n\036\007. \027\026\031\022. \211\235\026, 2023; 140 \f. /)6( )]TJ 0 Tc 0.075 Tw T* (Jejbov)Tj /Span<>> BDC ( )Tj EMC (R.R.)Tj /Span<>> BDC ( )Tj EMC [(P)35(r)-24(event)-32(ion and tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(l)-16(a)15(te st)17(omal com)10(pl)-31(ica)15(t)-31.9(ions: )]TJ 0.023 Tw T* (Cand. of)Tj /Span<>> BDC ( )Tj EMC [(med. sc)-24(i. diss. Uf)16(a, 2023; 140 p. \(In Russ.\))]TJ 0.038 Tw T* (33.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)-24(il)16(gr)-36.9(im)]TJ /Span<>> BDC ( )Tj EMC [(C, McInt)-10(yr)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(R, Baile)-11(y)]TJ /Span<>> BDC ( )Tj EMC [(M. P)35(r)-32(ospec)-16(t)-32(i)-16(ve audi)-23.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(p)32(ar)-33(ast)17(omal )]TJ -0.075 Tw -1.796 -1.25 Td [(her)-15(nia: p)25(r)-23.9(ev)-15(alence and asso)-16(c)-23.9(ia)15(ted comor)-24(bidi)-23.9(t)-32(ies. )]TJ /T1_2 1 Tf (Diseases of)Tj /Span<>> BDC ( )Tj EMC (the Colon )Tj 0.023 Tw T* [(& R)21(ectum)]TJ /T1_1 1 Tf [(. 2010; 53\(1\)6:1\22676. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/dcr.0b013e3181bdee8c)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.46 Tw T* [(3)0.5(4)0.5(.)]TJ /Span<>> BDC 1.333 0 Td ( )Tj EMC 0.512 0 Td [(\202)0.5(\035)0.5(\017)0.6(\n)0.5(\024)0.5(\r)]TJ /Span<>> BDC 3.167 0 Td ( )Tj EMC [(\215)0.5(.)0.5(\202)0.5(.)0.5(,)0.6( \213)0.5(\f)0.5(\036)0.6(\035)0.5(\036)0.5(\r)0.5(\017)0.5(\004)]TJ /Span<>> BDC 7.297 0 Td ( )Tj EMC [(\217)0.5(.)0.5(\200)0.5(,)0.5( \214)0.5(\017)0.5(\021)0.6(\r)0.5(\017)0.5(\027)0.5(\036)0.5(\027)0.6(\022)0.5(\024)]TJ /Span<>> BDC 8.048 0 Td ( )Tj EMC [(\202)0.5(.)0.5(\230)0.5(.)0.6(,)0.5( \017)]TJ /Span<>> BDC 3.962 0 Td ( )Tj EMC [(\f)0.6(\024)0.5(\026)0.5(\r)0.5(\021)0.5(.)13( )]TJ 0 Tc -0.004 Tw -24.319 -1.25 Td (\233\027\007\024\r\017\007\036\024\b\017\030\031\030\020\017\004\036\f\022\ \017\036 \021\036\b\027\024\035\024\020\017\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\031\030\020\036\027\021\027\t\b \026\002\024\035\036\r\026\027\017\016\ \b )Tj 0.115 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.821 0 Td [(\031\f\035\024\r\017\016\b )0.6(\024\021\007\026\035\036\027\027\024\020\024 )0.7(\020\026\030\027\017\024\027\026. )]TJ /T1_2 1 Tf 14.54 0 Td [(\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 )0.7(\255\r\032\025\020\f.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.008 Tc 0.349 Tw -15.362 -1.25 Td [(2)0.5(0)0.6(2)0.5(4)0.5(;)0.5(3)0.6(4)0.5(5)0.5(\()0.5(9)0.6(\))0.5(:)0.5(4)0.5(4)0.5(\226)0.6(4)0.5(6)0.5(.)0.6( d)-15.5(o)0.6(i)0.5(:)]TJ /Span<>> BDC 10.544 0 Td ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.008 Tw [(1)0.6(0)0.5(.)0.5(5)0.6(2)0.5(4)0.5(2)0.5(4)0.5(/)0.6(0)0.5(0)0.5(2)0.5(6)0.6(9)0.5(0)0.5(5)0.5(0)0.5(_)0.6(2)0.5(0)0.5(2)0.5(4)0.6(_)0.5(3)0.5(4)0.5(5)0.6(_)0.5(9)0.5(_)0.5(4)0.5(4)]TJ 0 0 0 1 k /GS1 gs 0 Tc 0.357 Tw 16.061 0 Td ( / )Tj 0.033 Tw -26.605 -1.25 Td [(Al)-31(imov)]TJ /Span<>> BDC ( )Tj EMC [(P.A., Eselev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC [(R.V., L)-32(i)-24(t)-24(v)-15.9(inenko)]TJ /Span<>> BDC ( )Tj EMC [(A.I., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. End)-16(ov)-15.9(ideosur)-32(gical )]TJ 0.335 Tw T* [(technol)30(o)-15.9(gies for ur)-32(gent diseases in a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(emo)17(te gar)-23.9(r)-37(ison. )]TJ /T1_2 1 Tf 0 Tw [(Militar)-43(y )]TJ 0.071 Tw T* [(Medical Jour)-14(nal)]TJ /T1_1 1 Tf [(. \(In Russ.\). 2024;345\(9\):44\22646. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.52424/002)Tj T* (69050_2024_345_9_44)Tj 0 0 0 1 k /GS1 gs 0.189 Tw T* (35.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Gonzalez)Tj /Span<>> BDC ( )Tj EMC [(RP, F)20(al)-31(imir)-10(sk)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(ME, Holev)-15(ar)]TJ /Span<>> BDC ( )Tj EMC [(MR. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-32(ole of)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(esa)-17(cr)-33(al )]TJ -0.031 Tw -1.796 -1.25 Td [(dr)-33(aina)-17(ge in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(pene)-12(tr)-32.9(a)15(t)-32(ing r)-23.9(ec)-16(t)15(al injur)-37(ies. )]TJ /T1_2 1 Tf [(J T)56(rauma)]TJ /T1_1 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(1998;45\(4\):656\226661. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/00005373-199810000-00002)Tj 0 0 0 1 k /GS1 gs 0.127 Tw T* (36.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\221\031\035\031\023\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\203. \221\016\032\036\035\026\016 \f\024\004\036\021\026\027\027\026\ \016 \021\030\026\r\n\026. \204\024\027\024\020\030\026\235\017\016. \222\ \215\002: )Tj -0.03 Tw -1.796 -1.25 Td [(\217\202 \253\217\031\f\f\022\017\005 \224\r\036\035\017\030\273, 2015; \ \f. 221\226223. / T)60(ul)35(upov)]TJ /Span<>> BDC ( )Tj EMC [(A.N. Sever)-24(e com)]TJ 0 Tw (-)Tj 0.095 Tw T* [(bined injur)-24(y. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(mono)-16(gr)-32.9(aph. S)15(t. P)30(e)-12(ter)-10(sbur)-32(g: RA \236Russian Jeweler\237 )]TJ 0.023 Tw T* [(P)20(ubl. 2015; pp. 221\226223. \(In Russ.\).)]TJ 0.276 Tw T* (37.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(F)-19(ields)]TJ /Span<>> BDC ( )Tj EMC 2.847 0 Td [(A, )0.6(Sal)-31(im)]TJ /Span<>> BDC ( )Tj EMC 3.972 0 Td [(A. )0.6(Contem)10(por)-33(ar)-23.9(y )0.5(dia)-17(gnosis )0.6(and )0.6(mana)-17(gement )]TJ 0.074 Tw -8.615 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(col)30(or)-24(ec)-15.9(t)15(al injur)-37(ies: wha)15(t you need t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(kno)-14(w. )]TJ /T1_2 1 Tf [(J. T)56(rauma Acute Care )]TJ 0 Tw T* (Surg.)Tj /T1_1 1 Tf 0.023 Tw [( 2024;97\(4\):497\226504. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/t)15.1(a.0000000000004352)]TJ 0 0 0 1 k /GS1 gs 0.33 Tw T* (38.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\202\035\017\f\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\206. \210\020\027\036\f\021\030\036\035\034\027\t\036 \030\026\027\ \036\027\017\016 \032\017\r\024\021\026. \210\f\024\002\036\027\027\024\f\ \021\017, )Tj 0.012 Tw -1.796 -1.25 Td [(\007\017\026\020\027\024\f\021\017\022\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.123 0 Td [(\035\036\004\036\027\017\036 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.838 0 Td [(\220\021\026\023\026\b )0.5(\n\036\007\017\006\017\027\f\022\024\005 )0.6(\220\r\026\022\031\026\006\017\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.945 0 Td (\f\024\r\030\036)Tj 0 Tw (-)Tj 0.206 Tw -24.906 -1.25 Td [(\n\036\027\027\t\b )0.6(\031\f\035\024\r\017\016\b: )0.6(\007\017\f\f. )0.5(... )0.6(\007-\030\026 )0.6(\n\036\007. )0.5(\027\026\031\022. )0.6(\222\215\002, )0.5(2016; )0.5(388 )0.6(\f. )0.5(/ )]TJ 0.111 Tw T* [(Al)-31(isov)]TJ /Span<>> BDC ( )Tj EMC [(P.G. Gunsho)17(t w)-14(ounds t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he abd)-15.9(omen. F)10(ea)15(tur)-23.9(es, dia)-17(gnost)-32(ics )]TJ 0.024 Tw T* [(and tr)-24(ea)15(tment a)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(st)15(a)-17(ges of)]TJ /Span<>> BDC ( )Tj EMC [(medical ev)-14.9(a)-17(cua)15(t)-32(ion in moder)-15(n condi)]TJ 0 Tw (-)Tj 0.023 Tw T* [(t)-32(ions. Dr. med. sc)-24(i. diss. S)15(t.P)30(e)-11.9(ter)-10(sbur)-32(g, 2016; 388 p. \(In Russ.\).)]TJ 0.177 Tw T* (39.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\215\036\030\036\b\024\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\203., \205\024\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\203., \003\031\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\025., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\023\t\021 \024\030\020\026)Tj 0 Tw (-)Tj 0.006 Tc 0.349 Tw -1.796 -1.25 Td (\027\017\026\006\017\017 \b\017\030\031\030\020\017\004\036\f\022\024\005\ \023\024\n\024\013\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\024\020\027\036\f\021\030\036\035\034\027\t\b \030\026\027\036\027\017\016\ \b)6( )]TJ 0 Tc 0.095 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\024\030\031\032\036\027\027\t\b \022\024\027\235\035\017\022\021\026\ \b \027\026)Tj /Span<>> BDC ( )Tj EMC (\222\036\r\036\030\027\024\n \025\026\r\022\026\036. )Tj /T1_2 1 Tf 0.037 Tw T* (\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 \255\ \r\032\025\020\f)Tj /T1_1 1 Tf [(. 2009;7:4\2269. / P)30(er)-24(ekhod)-16(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.N., F)10(ok)-16(in )]TJ 0.162 Tw T* [(Y)35(u.N., Z)20(uev)]TJ /Span<>> BDC ( )Tj EMC [(V.K., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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Sur)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4519-0018)Tj T* [(R)11(oman V. Eselev)-15.9(ich)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3249-233X)Tj T* [(P)40(avel A. Al)-30.9(imov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0007-3105-764X)Tj T* [(Oleg V. Bal)35.1(ur)-33(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7826-8056)Tj T* [(V)25(aler)-24(y N. Rumy)22.1(antsev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7526-6282)Tj 0 -1.218 TD [(Ser)-32(ge)-11(y N. Bar)-23.9(d)42(akov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-3804-6245)Tj 0 -1.218 TD [(K)25(onst)15(ant)-32(in Y)35.1(u. Z)25(o)17(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-0897-8921)Tj T* [(Dmi)-24(tr)-36.9(i)-16(i V. Obchinnikov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8408-5301)Tj T* (Denis A. Dymnikov)Tj /Span<>> BDC ( )Tj EMC (\227 0000-0002-4579-2027)Tj T* [(Mikhail S. K)25.1(or)-24(zhuk)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4579-2027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 542.1599 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.318 Tw 8 0 0 8 70.8661 529.3252 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\017\n)Tj /Span<>> BDC ( )Tj EMC (\230.\224., \215\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \204\031\f\026\017\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202. \222\r\024\036\r\030\036\n\036\027\027\026\016 \007\017\026\020\ )Tj 0 Tw (-)Tj 0.203 Tw -1.296 -1.25 Td (\027\024\f\021\017\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\021\017\n\026\035\034\027\026\016 \b\017\030\031\030\020\017\004\ \036\f\022\026\016 \021\026\022\021\017\022\026, \022\026\022 \024\f\027\ \024\r\026 \023\030\024)Tj 0 Tw (-)Tj 0.003 Tc 0.35 Tw 0 -1.25 TD (\235\017\035\026\022\021\017\022\017 \024\f\035\024\032\027\036\027\017\005\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC 12.9 0 Td [(\035\036\004\036\027\017\017 )0.5(\030\026\027\036\027\017\005 )0.5(\023\030\016\n\024\005 \022\017\001\022\017.)3( )]TJ /T1_3 1 Tf 0 Tc 0.195 Tw -12.9 -1.25 Td (\001\020\006\022\031\025\020\f\017\025\020\t \020\024\024\031\006\022\020\ \006\022\t \r\007\027\025\013\200)Tj /T1_0 1 Tf (. 2023;96\(1\):26\22629. / Kim)Tj /Span<>> BDC ( )Tj EMC (I.Y., )Tj 0.05 Tw T* [(P)40(anov)]TJ /Span<>> BDC ( )Tj EMC [(V.V., Musail)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.A. T)35(imel)35(y dia)-17(gnosis and opt)-32(imal sur)-32(gical t)15(a)-17(c)]TJ 0 Tw (-)Tj -0.015 Tw T* [(t)-32(ics as t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(basis for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(pl)-31(ica)15(t)-32(ions in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-23.9(ea)15(tment )]TJ 0.069 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC 1.116 0 Td [(r)-24(ec)-15.9(t)15(al )0.5(w)-14(ounds. )]TJ /T1_3 1 Tf 6.287 0 Td [(N)18(ational )0.6(Association )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 9.509 0 Td (Scientists)Tj /T1_0 1 Tf [(. )0.5(2023;96\(1\):26\226)]TJ 0.023 Tw -16.912 -1.25 Td (29. \(In Russ.\).)Tj 0.229 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\221\030\017\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC 4.102 0 Td [(\212.\200., )0.5(\025\030\033\022\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.013 0 Td [(\213.\200., )0.5(\202\035\036\022\f\036\036\r)]TJ /Span<>> BDC ( )Tj EMC 6.531 0 Td [(\212.\213., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.297 0 Td [(\f\024\026\r\021. )0.5(\200\024\036\027\027\024-)]TJ 0.197 Tw -21.239 -1.25 Td [(\023\024\035\036\r\026\016 \b\017\030\031\030\020\017\016. )0.5(\203\026\006\017\024\027\026\035\034\027\024\036 \030\031\022\024\r\024\007\ \f\021\r\024. )0.5(\204\024\f\022\r\026: \206\233\210\221\202\217-)]TJ 0.169 Tw T* [(\204\036\007\017\026, 2024; 1056 \f. / T)50(r)-37(ishk)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(D.V., Kr)-24(yukov)]TJ /Span<>> BDC ( )Tj EMC [(E.V., Alek)-10(seev)]TJ /Span<>> BDC ( )Tj EMC (D.E., )Tj 0.08 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Mil)-31(i)-24(t)15(ar)-23.9(y F)-19(ield Sur)-32(ger)-24(y: Na)15(t)-32(ional guidel)-31(ines. M)-23.9(osco)-14(w: GEOT)35(AR-)]TJ 0.023 Tw T* [(Media P)20(ubl. 2024; 1056 p. \(In Russ.\).)]TJ 0.017 Tc 0.604 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.346 0 Td (\213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021)0.5(.)17( )]TJ 0 Tc 0.124 Tw -1.346 -1.25 Td (4D-\022\024\027\006\036\023\006\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \035\036\004\036\027\017\017\ \r\027\036\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\005\ )Tj 0.111 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017. \200\f\036 \035\017 \021\026\ \022 \024\007\027\024\027\026\004\027\024? )Tj /T1_3 1 Tf 0 Tw (\004\031\f\022\023\032\020\021\026\020)Tj /T1_0 1 Tf 0.111 Tw (. 2025;1:59\226)Tj 0.011 Tc 0.403 Tw T* [(66. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.24412/1819-1495-2025-1-59-66)Tj 0 0 0 1 k /GS1 gs 0.403 Tw [( / Y)30.1(eselev)-15.8(ich)]TJ /Span<>> BDC ( )Tj EMC [(R.V.,)11( )]TJ 0 Tc 0.06 Tw T* [(Bal)35(yur)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(O.V., Rumy)22(antsev)]TJ /Span<>> BDC ( )Tj EMC [(V.N., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. 4 Dis a)Tj /Span<>> BDC ( )Tj EMC [(concept in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(sur)-31.9(gical )]TJ 0.178 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-32.9(aper)-37(i)-24(t)17(oneal r)-24(ec)-16(t)15(al w)-14(ounds. Is ever)-23.9(y)-16(t)-13(hingso)-16(clear? )]TJ /T1_3 1 Tf 0 Tw T* [(P)15(olytrauma)]TJ /T1_0 1 Tf 0.229 Tw [(. 2025;1:59\22666. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.24412/1819-1495-)Tj T* (2025-1-59-66)Tj 0 0 0 1 k /GS1 gs 0.339 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\230\r\004\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \210\r\004\017\027\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200. \210\f\027\024\r\027\t\036 \027\026\031\004\027\024-\023\030\026\ \022\021\017\004\036)Tj 0 Tw (-)Tj 0.326 Tw -1.296 -1.25 Td (\f\022\017\036 \017\021\024\020\017 \017\031\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \002\024\036\r\024\005 )Tj 0.333 Tw T* (\023\026\021\024\035\024\020\017\017 \023\036\030\017\024\007\026 \222\023\ \036\006\017\026\035\034\027\024\005 \r\024\036\027\027\024\005 \024\023\ \036\030\026\006\017\017. )Tj /T1_3 1 Tf 0 Tw (\002\016\021\027\024\023\022\t )Tj 0.273 Tw T* (\206\031\024\024\022\235\024\n\031\235 \211\031\027\025\025\031-\026\027\ \030\022\006\022\025\024\n\031\235 \020\n\020\030\027\026\022\022)Tj /T1_0 1 Tf (. 2024;43\(4\):457\226469. )Tj 0.004 Tc -0.004 Tw T* [(d)-16.1(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.194 0 Td [(10.17816/r)-16.1(mmar636549)]TJ 0 0 0 1 k /GS1 gs 0.35 Tw ( / Ivchenko)Tj /Span<>> BDC ( )Tj EMC 15.818 0 Td [(E.V., O)-24.1(vchinnikov)]TJ /Span<>> BDC ( )Tj EMC [(D.V.)3.9( )]TJ 0 Tc 0.046 Tw -18.012 -1.25 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(main sc)-24(ient)-32(if)-28(ic and p)25(r)-33(a)-17(c)-16(t)-32(ical r)-24(esul)56(ts of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he stud)17.1(y a)15(t t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Mil)-31(i)-24(t)15(ar)-23.9(y )]TJ 0.163 Tw T* [(Medical A)-25(cademy of)]TJ /Span<>> BDC ( )Tj EMC [(comba)15.1(t p)32(a)15(t)-13(hol)30(o)-16(g)16(y dur)-37(ing t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Spec)-24(ial Mil)-31(i)-24(t)15(ar)-23.9(y )]TJ 0 Tw T* [(oper)-33(a)15(t)-32(ion. )]TJ /T1_3 1 Tf -0.098 Tw 4.378 0 Td [(R)22(ussian Militar)-42.9(y Medical Academ)11(y R)21(epor)-40(ts.)]TJ /T1_0 1 Tf ( 2024;43\(4\):457\226)Tj 0.023 Tw -4.378 -1.25 Td [(469. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.17816/r)-16(mmar636549)]TJ 0 0 0 1 k /GS1 gs 0.107 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\036\f\017\022\017\027)Tj /Span<>> BDC ( )Tj EMC 3.852 0 Td [(\230.\203., )0.5(\215\036\030\036\b\024\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.143 0 Td [(\222.\203., )0.5(\210\027\027\017\006\036\r)]TJ /Span<>> BDC ( )Tj EMC 6.079 0 Td [(\230.\213., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.083 0 Td [(\f\024\026\r\021. )0.5(\233\021\026\023\027\024\036 )]TJ 0.19 Tw -21.453 -1.25 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\ \036 )0.5(\030\026\027\036\027\017\005 \r\027\036\002\030\033\001\017\027\027\024\020\ \024 \024\021\007\036\035\026 \023\030\016\n\024\005 )]TJ 0 Tw T* (\022\017\001\022\017. )Tj /T1_3 1 Tf 3.197 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf 0.04 Tw [(. 2024;23\(3\):41\22649. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -3.197 -1.25 Td (7556-2024-23-3-41-49)Tj 0 0 0 1 k /GS1 gs -0.001 Tw [( / P)30(esik)-15.9(in)]TJ /Span<>> BDC ( )Tj EMC [(I.N., P)30(er)-24(ekhod)-15.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(S.N., Onni)-24(tsev)]TJ /Span<>> BDC ( )Tj EMC (I.E., )Tj 0.307 Tw T* [(e)-12(t)15(al. )0.5(S)15(t)15.1(a)-17(ged sur)-31.9(gical )0.5(tr)-24(ea)15(tment )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 15.287 0 Td [(w)-14(ounds )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.964 0 Td [(t)-13(he )0.5(e)-18(xtr)-32.9(a-abd)-16(om)]TJ 0 Tw (-)Tj 0.015 Tc 0.549 Tw -20.251 -1.25 Td [(inal r)-24(ec)-16(tum. )]TJ /T1_3 1 Tf -0.015 Tw [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.549 Tw [(. 2024;23\(3\):41\22649. \(In Russ.\).)15.1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.33878/2073-7556-2024-23-3-41-49)Tj 0 0 0 1 k /GS1 gs -0.074 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\017\004\031\020\017\027)Tj /Span<>> BDC ( )Tj EMC (\202.\202.,\207\026\007\026\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\230., \204\026\030\022\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\200.\224., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210\f\024\002\036\027\027\024\f\021\017 )Tj 0.255 Tw -1.296 -1.25 Td (\024\022\026\026\027\017\016 \f\023\036\006\017\026\035\017\017\030\024\ \r\026\027\027\024\005 \b\017\030\031\030\020\017\004\036\f\022\024\005 \ \023\024\n\024\013\017 \030\026\027\036\027\t\n )Tj 0.035 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\032\017\r\024\021 \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \024\030\ \020\026\027\017\026\006\017\017 5-\020\024 \031\030\024\r\027\016. )Tj /T1_3 1 Tf 0 Tw (\211\031\027\025\025\031-)Tj 0.002 Tc 0.349 Tw -0 -1.25 Td (\026\027\030\022\006\022\025\024\n\022\235 \255\r\032\025\020\f)Tj /T1_0 1 Tf [(. 2023;344\(1\):4\22611. d)-15.7(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.002 Tw (10.52424/002690)Tj 0 Tc 0 Tw T* (50_2023_344_8_4)Tj 0 0 0 1 k /GS1 gs 0.219 Tw [( / P)-24(ichugin)]TJ /Span<>> BDC ( )Tj EMC 12.884 0 Td [(A.A., )0.5(Bad)42(al)30(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.I., Mar)-23.9(k)10(ev)-16(ich)]TJ /Span<>> BDC ( )Tj EMC [(V.Y)35.1(u., )]TJ 0.056 Tw -12.884 -1.25 Td [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 1.119 0 Td [(al. )0.6(F)9.9(ea)15.1(tur)-24(es )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.094 0 Td [(t)-13(he )0.5(p)25.1(r)-32(ov)-16(ision )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.781 0 Td [(spec)-24(ial)-30.9(ized )0.5(sur)-32(gical )0.6(car)-24(e )0.6(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 11.403 0 Td [(t)-13(hose )]TJ -0.034 Tw -25.398 -1.25 Td [(w)-14(ounded in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(st)17.1(oma)-17(ch in a)]TJ /Span<>> BDC ( )Tj EMC [(mil)-30.9(i)-24(t)15(ar)-24(y medical or)-31.9(ganiza)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he 5t)-13(h )]TJ 0 Tw T* (level. )Tj /T1_3 1 Tf -0.001 Tw 2.423 0 Td [(Militar)-42.9(y Medical )0.6(Jour)-14(nal)]TJ /T1_0 1 Tf [(. )0.5(2023;344\(1\):4\22611. )0.5(\(In )0.5(Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 24.214 0 Td (10)Tj 2.417 55 Td (.52424/00269050_2023_344_8_4)Tj 0 0 0 1 k /GS1 gs 0.061 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Hammer)Tj /Span<>> BDC ( )Tj EMC [(\330, Har)-24(per)]TJ /Span<>> BDC ( )Tj EMC [(D)20(A)15(T, R)-20(y)22(an)]TJ /Span<>> BDC ( )Tj EMC [(PD. P)25(A)35(S)-20.9(T: P)40(aleont)17.1(ol)30(o)-16(gical S)15(t)15(a)15(t)-32(ist)-32(ics )]TJ 0.161 Tw -1.296 -1.25 Td [(S)-16(of)-28(t)-32(w)-11.9(ar)-24(e P)40(a)-17(ck)-17(a)-16.9(ge for Educa)15.1(t)-32(ion and Da)15(t)15(a Anal)35(y)-13(sis. )]TJ /T1_3 1 Tf 0 Tw [(P)18(alaeontologia )]TJ T* (Electronica)Tj /T1_0 1 Tf 0.023 Tw (. 2001;4:9.)Tj 0.022 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Esposi)-24(t)17.1(o)]TJ /Span<>> BDC ( )Tj EMC [(T)25(J, Ingr)-33(aham)]TJ /Span<>> BDC ( )Tj EMC [(A, L)35(uche)-12(t)-29.9(te)]TJ /Span<>> BDC ( )Tj EMC [(F)24(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)13(easons t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(omi)-23.9(t digi)]TJ 0 Tw (-)Tj 0.068 Tw -1.296 -1.25 Td [(t)15(al )0.5(r)-23.9(ec)-16(t)15(al )0.5(e)-18(x)-10.9(am )0.5(in )0.5(tr)-32.9(auma )0.5(p)32(a)15(t)-32(ients: )0.6(no )0.5(f)-28(inger)-10(s, )0.6(no )0.5(r)-24(ec)-16(tum, )0.6(no )0.5(useful )]TJ 0.212 Tw T* [(addi)-24(t)-32(ional infor)-15.9(ma)15(t)-32(ion. )]TJ /T1_3 1 Tf (The)Tj /Span<>> BDC ( )Tj EMC [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(T)56.1(rauma.)]TJ /T1_0 1 Tf ( 2005;59\(6\):1314\226)Tj 0.023 Tw T* [(1319. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/01.t)15(a.0000198375.83830.62)]TJ 0 0 0 1 k /GS1 gs 0.205 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(T)50(r)-22(ust)]TJ /Span<>> BDC ( )Tj EMC [(MD, V)30(ei)-24(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC [(J, Br)-31.9(o)-14(wn)]TJ /Span<>> BDC ( )Tj EMC [(CVR, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)50(r)-32.9(auma)15(t)-32(ic r)-24(ec)-16(t)15(al injur)-36.9(ies: )]TJ 0.27 Tw -1.296 -1.25 Td [(Is t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(combina)15.1(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(puted t)17(omo)-16(gr)-33(aphy and r)-37(igid p)25(r)-32(o)-16(c)-16(t)17(os)]TJ 0 Tw (-)Tj 0.294 Tw T* [(copy )0.6(suf)-56(f)-28(ic)-24(ient? )]TJ /T1_3 1 Tf 7.341 0 Td (The)Tj /Span<>> BDC ( )Tj EMC 1.896 0 Td [(Jour)-13.9(nal )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 4.828 0 Td [(T)56(rauma )0.6(and )0.6(Acute )0.5(Care )0.5(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw -14.065 -1.25 Td [(2018;85\(6\):1033\2261037. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1097/T)35(A.0000000000002070)]TJ 0 0 0 1 k /GS1 gs 0.071 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\212\036\007\031\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\222., \037\t\002\031\035\016\022)Tj /Span<>> BDC ( )Tj EMC (\206.\203. \232\026\f\021\027\026\016 \b\017\030\031\030\020\017\016 \n\036\ \b\026\027\017\004\036\f\022\017\b )Tj 0.327 Tw -1.796 -1.25 Td [(\023\024\r\030\036\032\007\036\027\017\005. \222\215\002: \206\017\023\023\ \024\022\030\026\021, 2011; 571 \f. / Dedushk)-16(in)]TJ /Span<>> BDC ( )Tj EMC (V.S., )Tj 0.04 Tw T* (Cybuljak)Tj /Span<>> BDC ( )Tj EMC [(G.N. P)35(r)-37(i)-16(v)-15(a)15(te sur)-32(ger)-24(y of)]TJ /Span<>> BDC ( )Tj EMC [(mechanical injur)-37(ies. S)15(t. P)30(e)-12(ter)-10(sbur)-31.9(g: )]TJ 0.023 Tw T* [(Hippo)-16(cr)-32.9(a)15(tes P)20(ubl. 2011; 571 p. \(In Russ.\).)]TJ 0.239 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\231\031\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\202.\230., \213\030\036\f\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\204., \212\r\024\030\024\027\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200. \221\030\026\r\n\026 \023\030\016\n\024\005 )Tj 0.004 Tc 0.35 Tw -1.796 -1.25 Td (\022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\017\030\027\024\036 \r\030\036\n\016 \(\024\002\024\030 \035\017\021\ \036\030\026\021\031\030\t\). )Tj /T1_3 1 Tf (\211\027\024\023\025\022\n \205\020\025\n\023-)Tj 0 Tc 0.257 Tw T* (\004\027\023\027\032\240\r\032\b\024\n\031\b\031 \r\025\022\021\027\032\024\ \022\023\027\023\020. \215\027\030\022\006\022\025\020.)Tj /T1_0 1 Tf ( 2013; \222\036\030. 11. \200\t\023. )Tj 0.089 Tw T* [(1, \f. 127\226133. / S)-16(hugaev)]TJ /Span<>> BDC ( )Tj EMC [(A.I., Er)-33(ast)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(A.M., Dvor)-23.9(y)22(ank)-16(in)]TJ /Span<>> BDC ( )Tj EMC [(D.V. R)13(ec)-16(t)15(al )]TJ 0.033 Tw T* [(tr)-33(auma in c)-24(i)-15.9(v)-16(il)-31(ian t)-31.9(ime \(l)-31(i)-23.9(ter)-33(a)15(tur)-23.9(e r)-24(ev)-16(iew\). )]TJ /T1_3 1 Tf (Bulletin of)Tj /Span<>> BDC ( )Tj EMC [(S)28(t. P)15(etersburg )]TJ 0.023 Tw T* [(S)28(tate U)22(niv)13(ersity)]TJ /T1_0 1 Tf (. 2013; \(1\):127\226131. \(In Russ.\).)Tj 0.291 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\222\036\007\036\035\034\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\222., \212\024\030\024\r\f\022\017\b)Tj /Span<>> BDC ( )Tj EMC (\206.\203. \204\031\035\034\021\017\f\030\036\024\r\026\016 \022\024\n\023\ \034\033)Tj 0 Tw (-)Tj 0.043 Tw -1.796 -1.25 Td (\021\036\030\027\026\016 \021\024\n\024\020\030\026\235\017\016 \r\f\036\ \020\024 \021\036\035\026 \022\026\022 \220\021\026\023 \030\026\027\027\ \036\005 \007\017\026\020\027\024\f\021\017\022\017 \023\024\035\017)Tj 0 Tw (-)Tj 0.151 Tw T* (\021\030\026\r\n\t \(\024\002\024\030 \035\017\021\036\030\026\021\031\030\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\002\f\021\r\036\027\027\t\005 \024\023\t\021 \017\f\023\024\035\034\ \024\r\026\027\017\016\). )Tj /T1_3 1 Tf 0.314 Tw T* (\206\020\030\022\031\f\031\b\022\t)Tj /Span<>> BDC ( )Tj EMC 5.346 0 Td [(\227 )0.5(\033\032\020\n\023\022\n\020)]TJ /T1_0 1 Tf [(. )0.5(2017;65\(5\):22\22630. )0.6(/ Sedelnikov)]TJ /Span<>> BDC ( )Tj EMC 20.588 0 Td (S.S., )Tj 0.018 Tw -25.935 -1.25 Td [(Dor)-32(ovsk)-15.9(ikh)]TJ /Span<>> BDC ( )Tj EMC [(G.N. Whole-Bod)17.1(y mul)56(t)-32(ide)-11.9(tec)-16(t)17(or com)10(puted t)17(omo)-16(gr)-33(aphy as )]TJ -0.034 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC [(st)15(a)-17(ge of)]TJ /Span<>> BDC ( )Tj EMC [(ear)-30(l)35(y dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(pol)35(y)-16(tr)-33(auma \(r)-24(ev)-15.9(iew of)]TJ /Span<>> BDC ( )Tj EMC [(l)-31(i)-24(ter)-32.9(a)15(tur)-24(e and o)-14(wn )]TJ 0 Tw T* [(e)-18(xper)-36.9(ience\). )]TJ /T1_3 1 Tf 0.023 Tw 5.341 0 Td [(R)20(adiology)]TJ /Span<>> BDC ( )Tj EMC [(\227 p)46(ractice. )]TJ /T1_0 1 Tf (2017;65\(5\):22\22630. \(In Russ.\).)Tj 0.013 Tc 0.459 Tw -5.341 -1.25 Td [(1)0.5(3)0.6(.)]TJ /Span<>> BDC 1.333 0 Td ( )Tj EMC 0.512 0 Td [(\221)0.5(\017)0.6(\n)0.5(\036)0.6(\030)0.5(\002)0.5(\031)0.6(\035)0.5(\026)0.6(\021)0.5(\024)0.6(\r)]TJ /Span<>> BDC 5.912 0 Td ( )Tj EMC [(\200)0.5(.)0.6(\204)0.5(.)0.5(,)0.6( \206)0.6(\026)0.5(\030)0.5(\036)0.6(\036)0.5(\r)]TJ /Span<>> BDC 6.345 0 Td ( )Tj EMC [(\217)0.5(.)0.6(\203)0.5(.)0.5(,)0.6( \205)0.6(\026)0.5(\016)0.6()0.5(\024)0.6(\r)]TJ /Span<>> BDC 6.416 0 Td ( )Tj EMC [(\217)0.6(.)0.5(\217)0.6(.)0.5(,)0.6( \017)]TJ /Span<>> BDC 3.802 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.6(\r)0.5(\021)0.6(.)13( )]TJ 0.017 Tc 0.626 Tw -24.32 -1.25 Td (\216\017\030\031\030\020\017\004\036\f\022\026\016 \021\026\022\021\017\022\ \026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\021\030\026\r\n\026\021\017\004\036\f\022\017\b \023\024\r\030\036\032\007\ \036\027\017\016\b)17.1( )]TJ 0.011 Tc 0.408 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. )Tj /T1_3 1 Tf (\215\027\030\022\006\022\025\024\n\022\235 \020\f\017\026\020\025\020\200\ )Tj /T1_0 1 Tf [(. 2015;36\(1\):50\22662. /)11( )]TJ 0 Tc 0.1 Tw T* [(T)35(imer)-24(bul)-15.9(a)15(t)17(ov)]TJ /Span<>> BDC ( )Tj EMC [(V.M., Gar)-24(eev)]TJ /Span<>> BDC ( )Tj EMC [(R.N., F)20(a)15(y)22(a)-24(zov)]TJ /Span<>> BDC ( )Tj EMC [(R.R., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Sur)-32(gical t)15(a)-17(c)-16(t)-32(ics )]TJ -0.001 Tw T* [(for tr)-33(auma)15(t)-32(ic injur)-37(ies of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he col)30(on. )]TJ /T1_3 1 Tf (Medical almanac)Tj /T1_0 1 Tf (. 2015;36\(1\):50\226)Tj 0.023 Tw T* (62. \(In Russ.\).)Tj 0.03 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Johnson)Tj /Span<>> BDC ( )Tj EMC (EK, Judge)Tj /Span<>> BDC ( )Tj EMC [(T, L)35.1(und)17(y)]TJ /Span<>> BDC ( )Tj EMC [(J, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Dia)-17(gnost)-32(ic pel)30(v)-16(ic com)10(puted )]TJ 0.023 Tw -1.796 -1.25 Td [(t)17(omo)-16(gr)-33(aphy in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(r)-23.9(ec)-16(t)15(al-injur)-24(ed comba)15(t casual)56(t)-10(y. )]TJ /T1_3 1 Tf [(Militar)-43(y Medicine.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2008;173\(3\):293\226299. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.7205/milmed.173.3.293)Tj 0 0 0 1 k /GS1 gs 0.129 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Khan)Tj /Span<>> BDC ( )Tj EMC (MS, Khan)Tj /Span<>> BDC ( )Tj EMC [(BM, Na)-23.9(z)]TJ /Span<>> BDC ( )Tj EMC [(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Is est)-32(ima)15.1(ted bulle)-11.9(t tr)-33(ajec)-16(t)17(or)-23.9(y )]TJ -0.019 Tw -1.796 -1.25 Td (a)Tj /Span<>> BDC ( )Tj EMC [(r)-24(el)-31(iable p)25(r)-23.9(edic)-16(t)17(or of)]TJ /Span<>> BDC ( )Tj EMC [(sever)-24(e injur)-24(y? Case r)-23.9(epor)-22(t of)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(t)-12.9(hor)-33(a)-17(co-abd)-16(om)]TJ 0 Tw (-)Tj 0.097 Tw T* [(inal gunsho)17(t wi)-24(t)-13(h a)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-32(o)17(tr)-33(a)-17(c)-15.9(ted tr)-32.9(ajec)-16(t)17(or)-24(y mana)-17(ged nonoper)-33(a)15(t)-32(i)-15.9(vel)35(y. )]TJ /T1_3 1 Tf 0.023 Tw T* [(BMCR)21(es N)17(o)13(tes)]TJ /T1_0 1 Tf [(. 2013;63\(6\):1\2264. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1186/1756-0500-6-63)Tj 0 0 0 1 k /GS1 gs 0.043 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)-32(avenson)]TJ /Span<>> BDC ( )Tj EMC (GS, Cohen)Tj /Span<>> BDC ( )Tj EMC [(A. Mana)-17(gement of)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(ec)-16(t)15.1(al injur)-37(ies. )]TJ /T1_3 1 Tf 0 Tw [(Amer)-36.9(ican )]TJ 0.023 Tw -1.796 -1.25 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-42.9(y. )]TJ /T1_0 1 Tf 0 Tw (1971;122\(2\):226\226230)Tj 0.017 Tc 0.612 Tw T* (17.)Tj /Span<>> BDC ( )Tj EMC 1.863 0 Td (\221\030\017\001\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \025\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\200., \232\031\023\030\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\202.\215., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, 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0 obj <> endobj 927 0 obj <> endobj 926 0 obj <> endobj 925 0 obj <> endobj 858 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.309 Tw 10 0 0 10 42.5197 724.8299 Tm (\030\031\021\017\027\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\ \017\016 \023\030\036\f\035\036\007\031\033\021 \006\036\035\034 \023\030\ \024\235\017)Tj 0 Tw (-)Tj -0.035 Tw 0 -1.218 TD (\035\026\022\021\017\022\017 \017\027\235\036\022\006\017\024\027\027\t\b\ \024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\024\030\024\027\t \ \022\035\036\021)Tj 0 Tw (-)Tj 0.096 Tw T* (\004\026\021\022\017 \021\026\026. \210\007\027\026\022\024 11 \030\036\ \f\023\024\027\007\036\027\021\024\r \023\031\021\036\n \030\031\021\017\ \027\027\024)Tj 0 Tw (-)Tj 0.271 Tw T* (\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \030\026\f\f\004\ \017\021\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\031\033 )Tj 0.093 Tw T* (\007\017\026\020\027\024\f\021\017\022\031 \017\027\235\036\022\006\017\024\ \027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\024\030\ \024\027\t )Tj 0.219 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r \021\026\026, \026)Tj /Span<>> BDC ( )Tj EMC (10 \030\036\f\023\024\027\007\036\027\021\024\r )Tj 0.695 Tw 0 -1.218 TD (\026\030\020\031\n\036\027\021\017\030\024\r\026\035\017 \r\t\023\024\035\ \027\036\027\017\036 \007\026\027\027\024\020\024 \220\035\036\n\036\027\ \021\026 )Tj -0.014 Tw 0 -1.218 TD (\025\024\027\006\036\023\006\017\017 \030\036\026\035\017\026\006\017\036\ \005 \021\030\036\002\024\r\026\027\017\005 \030\036\020\035\026\n\036\027\ \021\017\030\031\033)Tj 0 Tw (-)Tj 0.107 Tw T* (\013\017\b \007\024\022\031\n\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\017\005 \f\021\026\030\001\036\020\024 \n\036\007\017\ \006\017\027\f\022\024\020\024 )Tj 0 Tw T* (\027\026\004\026\035\034\027\017\022\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 578.6938 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.214 Tw 10 0 0 10 42.5197 554.3378 Tm (\203\036\007\024\f\021\026\021\024\004\027\026\016 \f\024\020\035\026\f\024\ \r\026\027\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.289 Tw T* (\001\017\027\f\021\r\024 \r\024\023\030\024\f\024\r \024)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \n\036\021\024\007\024\r \007\017\026\020\027\024\f\ \021\017\022\017 )Tj 0.027 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\017 \b\017\030\031\030\020\017\004\036\f\022\024\ \020\024 \035\036\004\036\027\017\016 \200\002\217\215\025 \f\r\017\007\036\ \021\036\035\034)Tj 0 Tw (-)Tj 0.023 Tw T* (\f\021\r\031\036\021 \024\002 \024\021\f\031\021\f\021\r\017\017 \036\007\ \017\027\024\020\024 \026\035\020\024\030\017\021\n\026 \007\017\026\020\ \027\024\f\021\017\022\017 )Tj 0.055 Tw T* (\200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233. \204\017\027\017\n\026\035\034\027\024\036 \022\024\035\017\ \004\036\f\021\r\024 \030\036\f\023\024\027\007\036\027)Tj 0 Tw (-)Tj 0.293 Tw T* (\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233 \023\030\036\007\023\024\004\017\021\026\035\024 \022\024\n\ \023\034\033\021\036\030\027\031\033 \021\024\n\024\020\030\026)Tj 0 Tw (-)Tj -0.001 Tw T* (\235\017\033 \007\035\016 \007\017\026\020\027\024\f\021\017\022\017 \200\ \002\217\215\025, \004\021\024, \r\036\030\024\016\021\027\024, \024\021\ \030\026\032\026\036\021 )Tj 0.394 Tw T* (\027\036\007\024\024\006\036\027\022\031 \007\017\026\020\027\024\f\021\017\ \004\036\f\022\024\020\024 \023\024\021\036\027\006\017\026\035\026 \r\027\ \031\021\030\017)Tj 0 Tw (-)Tj 0.301 Tw T* (\023\030\024\f\r\036\021\027\t\b \n\036\021\024\007\024\r \017\f\f\035\036\ \007\024\r\026\027\017\016 \023\030\016\n\024\005 \022\017\001\022\017. \ )Tj 0.153 Tw T* [(\215\030\024\r\036\007\036\027\027\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\r\t\016\r\017\035\024 )0.6(\030\026\027\024\030\024\007\027\024\f\021\034 )]TJ 0.25 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \021\026\022\021\017\022\ \017 \035\036\004\036\027\017\016 \200\002\217\215\025, \022\026\022 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.012 Tw T* (\007\036\035\034\027\t\b \233\204\233, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \r\f\036\b \211\204\215 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n. \203\036\026\r\017\f\017\n\024 )Tj 0.131 Tw T* [(\024\021 )0.5(\f\021\026\032\026 )0.5(\b\017\030\031\030\020\024\r )0.5(\023\030\024\f\035\036\032\017\r\026\035\024\f\034 )0.5(\030\026\035\017\004\017\036 )0.6(\r\020\035\016)]TJ 0 Tw (-)Tj 0.167 Tw T* (\007\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC 3.242 0 Td [(\006\036\035\036\f\024\024\002\030\026\027\024\f\021\034 )0.5(\030\036\026\035\017\026\006\017\017 )0.5(\021\036\b )0.5(\017\035\017 \017\027\t\b )]TJ 0.263 Tw -3.242 -1.218 Td [(\220\035\036\n\036\027\021\024\r )0.6(4D\226\022\024\027\006\036\023\006\017\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 13.4 0 Td [(\200\002\217\215\025, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.873 0 Td (\n\036\021\024\007\017\022\031 )Tj 0 Tw -18.273 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\034 \017\b\ \r\t\023\024\035\027\036\027\017\016.)Tj 0.244 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \023\024\r\t\001\036\027\017\016 \022\026\004\036\f\ \021\r\026 \024\022\026)Tj 0 Tw (-)Tj 0.661 Tw T* (\t\r\026\036\n\024\005 \b\017\030\031\030\020\017\004\036\f\022\024\005\ \023\024\n\024\013\017 \023\024\f\021\030\026\007\026\r\001\017\n )Tj 0.143 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \027\036\024\002\b\024\007\017\n\024 \031\021\024\004\ \027\036\027\017\036 \021\026\022\021\017\004\036\f\022\017\b \023\024\007\ \b\024)Tj 0 Tw (-)Tj 0.085 Tw T* (\007\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\021\036\b\027\017\004\036\f\022\017\b \026\f\023\036\022\021\024\r \017\ \b \023\030\026\022\021\017\004\036\f\022\024\005 \030\036\026\035\017)Tj 0 Tw (-)Tj 0.135 Tw T* (\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233. \210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\t\b \023\031\021\036\005 \030\036\001\036\027\017\016\ )Tj 0.263 Tw T* (\007\026\027\027\024\005 \026\007\026\004\017 \016\r\035\016\036\021\f\016\ \023\030\024\r\036\007\036\027\017\036 \022\024\035\035\036\022\021\017\ \r\027\024\005 )Tj 0.135 Tw T* (\220\022\f\023\036\030\021\027\024\005 \024\006\036\027\022\017 \n\036\021\ \024\007\024\n \212\036\035\235\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\035\036\004\036\027\017\036\n )Tj 0.03 Tw T* [(\020\030\031\023\023\t \220\022\f\023\036\030\021\024\r. \215\030\017\027\ \016\021\017\036 )0.5(\022\024\027\f\036\027\f\031\f\027\024\020\024 \030\036\001\036\027\017\016\ )]TJ 0.127 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \f\023\024\030\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\026\032\027\t\n \r\024\023\030\024\f\026\n \007\017\026\020\027\024\f\ )Tj 0 Tw (-)Tj 0.301 Tw T* (\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\017 \035\036\004\036\027\017\016 \023\024\r\024\ \035\017\021 \031\035\031\004\001\017\021\034 \027\036\023\024)Tj 0 Tw (-)Tj 0.066 Tw T* [(\f\030\036\007\f\021\r\036\027\027\t\036 \030\036\031\035\034\021\026\021\ \t )0.5(\035\036\004\036\027\017\016 \007\026\027\027\024\005 \022\026\021\036\020\ \024\030\017\017 )]TJ 0 Tw T* (\023\026\006\017\036\027\021\024\r.)Tj /T1_3 1 Tf T* (\224\035\032\027\017\031\032\022\025\017\255\020\205: )Tj /T1_1 1 Tf 0.738 Tw 8.544 0 Td (\025\024\035\035\036\022\021\017\r \026\r\021\024\030\024\r \r\t\030\026\ \032\026\036\021 )Tj 0.23 Tw -8.544 -1.218 Td (\002\035\026\020\024\007\026\030\027\024\f\021\034 \230\002\030\026\020\017\ \n\024\r\031 \202\035\036\022\f\026\027\007\030\031 \217\036\235\026\021\ \024\r\017\004\031 )Tj 0 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\024\021\024\r\022\031 \017\035\035\033\f\021\030\026\006\ \017\017 \022)Tj /Span<>> BDC ( )Tj EMC (\030\031\022\024\023\017\f\017.)Tj /T1_3 1 Tf T* [(GRA)28(T)-23(ITUDE: )]TJ /T1_1 1 Tf 0.144 Tw 5.35 0 Td [(T)47(he)]TJ /Span<>> BDC ( )Tj EMC (team of)Tj /Span<>> BDC ( )Tj EMC [(aut)-13(hor)-10(s e)-18(xp)25(r)-24(esses i)-24(ts gr)-33(a)15(t)-32(i)]TJ 0 Tw (-)Tj 0.104 Tw -5.35 -1.218 Td [(tude t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(Ibr)-33(a)-17(gimov Ale)-17.9(x)-11(ander R)13(ef)16(a)15(t)17(ov)-16(ich for p)25(r)-24(ep)32(ar)-36.9(ing )]TJ 0 Tw T* [(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(ill)35.1(ustr)-33(a)15(t)-32(ions for t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(manuscr)-36.9(ipt.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.522 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf [( \205)27.6(\r)-4.3(\032\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\220)1.4(.)7.3(\003)-2.3(.)7.8(, )]TJ 0 Tw T* [(\036)24.3(\024)9.8(\027)-20.6(\f)3.3(\027)6.6(\021)5.5(\022)19.4(\007)]TJ /Span<>> BDC ( )Tj EMC [(\206)93.9(.)28.5(\211)24.3(.)7.8(, \202)15.6(\031)4.9(\032)7.9(\255)-9.1(\r)8.8(\n)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.4(.)43.7(\205)-2.1(.)]TJ /T1_1 1 Tf 0.572 Tw T* [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.01 Tc 0.582 Tw [( \220)-3.5(\013)-2.1(\026\025\022)-2.3(\n\031\021)]TJ /Span<>> BDC 19.396 0 Td ( )Tj EMC [(\220)-8.6(.)-2.7(\003)-12.3(.)-2.2(,)-10( )]TJ 0 Tc 0 Tw -19.396 -1.218 Td [(\221)5(\020)-5.2(\f)9.7(\005)4.5(\032)3(\020)]TJ /Span<>> BDC ( )Tj EMC [(\217)27.6(.)28.5(\211)24.3(.)7.8(, \207)8(\031)3(\023)4.1(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)27.5(\224)26.6(.)7.8(, \206)-10.5(\r)7.2(\026)8.8(\t)10.2(\025)10.1(\006)2.7(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)29.3(\001)28.8(.)]TJ /T1_1 1 Tf 0.894 Tw 23.244 64.543 Td [(\222)17.2(\021)-21.5(\026)-11.8(\021)-17.7(\017)-2.4(\f)-36(\021)-17.7(\017)4.6(\004)-8.2(\036)-10.4(\f)-1.6(\022)-19.1(\026)-21.1(\016 \024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\026\027)-0.6(\026)-33.1(\035)2.2(\017)2.7( \007)-20.1(\026\027)1.7(\027)1.7(\t)-12.8(\b)-9.4(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -0.01 Tc 0.01 Tw 0 -1.218 TD [(\221)-5(\020)-8.2(\032)-9.9(\030)-5.1(\020)-5.2(\n\031\021)]TJ /Span<>> BDC 3.824 0 Td ( )Tj EMC [(\205)-12.1(.)19.3(\001)18.9(.)-2.2(,)-10( \003)-27.3(\f\022)-5.4(\026)-5.9(\031\021)]TJ /Span<>> BDC 5.228 0 Td ( )Tj EMC [(\004)19.3(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -9.052 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw 7.694 0 Td [( \036)14.3(\024\027)-30.5(\f)-6.7(\027)-3.4(\021)-4.5(\022)9.3(\007)]TJ /Span<>> BDC 3.85 0 Td ( )Tj EMC [(\206)83.9(.)18.5(\211)14.3(.)-2.1(,)-10( \003)-27.3(\f\022)-5.4(\026)-6(\031\021)]TJ /Span<>> BDC 5.186 0 Td ( )Tj EMC [(\004)19.3(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -16.729 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \205)17.6(\r)-14.3(\032)-9.9(\031\021)]TJ /Span<>> BDC 9.622 0 Td ( )Tj EMC [(\220)-8.6(.)-2.7(\003)-12.3(.)-2.1(,)-10( \217)-3.2(\021)6.1(\007\022)-2.7(\025\025\022)-2.3(\n\031\021)]TJ /Span<>> BDC 7.152 0 Td ( )Tj EMC [(\220)-8.6(.)18.5(\211)14.3(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -16.775 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.276 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.8(y)-11.8(:)]TJ /T1_4 1 Tf [( D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(i)3.4(i)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)15.8(u)6.1(r)2.4(ov)33.6(, )]TJ 0 Tw 0 -1.218 TD [(R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(E)-3.6(s)4.9(e)-1.9(l)4.8(e)-4(v)-28.6(i)2.6(c)1.9(h)-6(, M)10.5(i)8.4(h)4.8(a)-2(i)7.4(l)]TJ /Span<>> BDC ( )Tj EMC [(S)2.1(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.4(o)1.3(r)-14.6(z)8.1(h)8.2(u)4.6(k)]TJ /T1_1 1 Tf 1.014 Tw T* [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0.088 Tw -15.798 -1.218 Td [(D)-6.1(e)-2.6(n)6.2(i)11(s)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-10.9(ym)4.7(n)6.2(i)7.9(k)12.9(ov)33.5(, O)-7.4(l)4.8(e)-3.5(g)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(al)4.3(u)6.1(r)7.7(a)-14(, K)13.3(on)8.1(s)-10.7(t)2.3(a)-0.8(n)3.8(t)-25.2(i)8.4(n)]TJ /Span<>> BDC ( )Tj EMC [(U)25.4(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)5.1(o)1.4(t)1.4(o)-0.6(v)33.6(, )]TJ -0.005 Tc 0.005 Tw T* [(V)20.9(a)-5.1(le)-6.7(r)-40.3(i)-5.1(y)]TJ /Span<>> BDC 2.664 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(R)5.2(umy)-1.2(a)-5.8(n)-1.2(t)-34.1(se)-9(v)]TJ /T1_1 1 Tf -0.002 Tc 1.448 Tw -3.752 -1.218 Td [(S)5(t)-29.7(a)-10.4(t)-39.4(i)0.7(s)-21.9(t)-39.4(i)3.2(c)-13.8(a)-3.5(l)-2( d)-1.3(a)-10.4(t)-29.7(a)-2( p)-5.8(r)-8(o)-9(c)-1.8(e)-15.3(s)-14.8(s)-18.6(i)5.1(n)-3.9(g)-1.9( an)-6.6(d)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 22.11 0 Td ( )Tj -22.11 -1.218 Td [(S)5.6(e)-1.7(r)2.3(g)-2.5(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(N)13.1(.)]TJ /Span<>> BDC ( )Tj EMC [(B)6.7(ar)1.4(d)1.9(a)1.7(k)13(o)-0.6(v)33.6(, P)30.8(a)-4.4(v)6.6(e)-1.9(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.7(l)4.3(i)8.4(m)-1.1(o)-0.6(v)]TJ /T1_1 1 Tf T* [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf [( R)7.2(om)4.3(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(E)-3.5(s)4.9(e)-1.9(l)4.8(e)-4(v)-28.6(i)2.6(c)1.8(h)-6(, P)30.9(a)-4.4(v)6.6(e)-1.9(l)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.3(i)8.5(m)-1.1(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf -0.006 Tc 0.006 Tw 3.238 0 Td [( D)-8(mi)-5(t)-11.4(r)-41.3(i)-2.6(i)]TJ /Span<>> BDC 2.951 0 Td ( )Tj EMC [(A)-18.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(S)9.8(ur)-3.6(o)-6.5(v)27.6(,)-6( D)-8(mi)-5.1(t)-11.4(r)-41.2(i)-2.6(i)]TJ /Span<>> BDC 5.491 0 Td ( )Tj EMC [(V)47.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(O)-18.2(v)1.4(c)-4.2(hi)2.5(n)-0.8(ni)1.9(k)6.9(o)-6.6(v)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -13.714 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.311 Tw T* [(\222\031\030\024\r )0.5(\212\n\017\021\030\017\005 )0.6(\202\035\036\022\f\026\027\007\030\024\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 13.948 0 Td [(\227 )0.5(\007.\n.\027., )0.6(\023\030\024\235\036\f)]TJ 0 Tw (-)Tj 0.238 Tw -13.948 -1.218 Td (\f\024\030, \027\026\004\026\035\034\027\017\022 \022\026\235\036\007\030\ \t \r\024\036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\ \017\017 )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.038 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 02-4519-0018; )Tj 0 Tw T* (SPIN-\022\024\007: 5346\2261613)Tj 0.124 Tw T* (\213\f\036\035\036\r\017\004 \217\024\n\026\027 \200\035\026\007\017\n\017\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \027\026\004\026\035\034\027\017\022 )Tj 0.238 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\ \036\027\017\016 \022\035\017\027\017\022\017 \022\026\235\036\007\030\t\ \r\024\036\027)Tj 0 Tw (-)Tj -0.035 Tw T* (\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\ \036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\ \036\n\017\017 )Tj 0.003 Tw T* (\017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, \232\210\211\200\210 \253\222\026\ \027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005 )Tj 0.326 Tw T* [(\n\036\007\017\022\024-\f\024\006\017\026\035\034\027\t\005 )0.6(\017\027\f\021\017\021\031\021\273, )0.6(\020.)]TJ /Span<>> BDC ( )Tj EMC 14.925 0 Td (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; )Tj 0 Tw -14.925 -1.218 Td (ORCID 0000-0003-3249-233X; SPIN-\022\024\007: 1037\2268736)Tj 0.222 Tw T* (\202\035\017\n\024\r \215\026\r\036\035 \202\035\017\n\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\031\001\026\021\036\035\034 \024\030\007\017\027\026\021\031\ \030\t )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.042 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0009-00\ 07-3105-764X; )Tj 0 Tw T* (SPIN-\022\024\007: 5928\2263805)Tj 0.327 Tw T* (\207\026\035\033\030\026 \210\035\036\020 \200\026\035\036\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030\001\017\005 \023\030\036)Tj 0 Tw (-)Tj 0.821 Tw T* (\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\ \036\027\027\024-\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017\ )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0.337 Tw T* [(\217\205, )0.5(\232\210\211\200\210 )0.6(\253\222\026\027\022\021-\215\036\021\036\030\002\031\030\020\f\022\017\005\ )0.5(\n\036\007\017\022\024-\f\024\006\017\026\035\034)]TJ 0 Tw (-)Tj 0.006 Tw T* (\027\t\005 \017\027\f\021\017\021\031\021\273, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-)Tj 0 Tw T* (7826-8056; SPIN-\022\024\007: 9260\2269850)Tj 0.229 Tw T* (\217\031\n\016\027\006\036\r \200\026\035\036\030\017\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \023\030\036\023\024\007\026)Tj 0 Tw (-)Tj 0.2 Tw T* (\r\026\021\036\035\034 \022\026\235\036\007\030\t \r\024\036\027\027\024\ -\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \200\024\036\027\ \027\024-)Tj 0.429 Tw T* (\n\036\007\017\006\017\027\f\022\024\005 \026\022\026\007\036\n\017\017 \ \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, )Tj 0.571 Tw T* (\020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0000-00\ 01-7526-6282; )Tj 0 Tw T* (SPIN-\022\024\007: 8166\2269820)Tj 0.19 Tw T* (\207\026\030\007\026\022\024\r \222\036\030\020\036\005 \203\017\022\024\ \035\026\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \023\030\036\023\024\007\026\r\026)Tj 0 Tw (-)Tj 0.253 Tw T* (\021\036\035\034 \022\026\235\036\007\030\t \027\036\030\r\027\t\b \002\024\ \035\036\027\036\005, \022\026\235\036\007\030\t \027\036\235\030\024)Tj 0 Tw (-)Tj 0.102 Tw T* (\035\024\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\030\036\027\021\027\024\005 \021\036\030\026\023\017\017\ \200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 )Tj -0.001 Tw T* (\026\022\026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 \217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; )Tj 0 Tw T* (ORCID 0000-0002-3804-6245; SPIN-\022\024\007: 2351-4096)Tj 0.002 Tw T* (\003\024\021\024\r \025\024\027\f\021\026\027\021\017\027 \224\030\034\036\ \r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\035\031\001\026\021\036\035\034 \024\030\007\017\027\026\021\031\ \030\t )Tj 0.15 Tw T* (\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\024\005 \026\022\ \026\007\036\n\017\017 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026 \204\210 )Tj 0 Tw T* (\217\205, \020.)Tj /Span<>> BDC ( )Tj EMC (\222\026\027\022\021-\215\036\021\036\030\002\031\030\020; ORCID 0009-00\ 05-0897-8921)Tj 0.513 Tw T* (\210\r\004\017\027\027\017\022\024\r \212\n\017\021\030\017\005 \200\026\ \035\036\030\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024)Tj 0 Tw (-)Tj 0.354 Tw T* (\006\036\027\021, \027\026\004\026\035\034\027\017\022 \024\021\007\036\035\ \026 \024\030\020\026\027\017\026\006\017\017 \027\026\031\004\027\024\005\ \030\026)Tj 0 Tw (-)Tj 0.333 Tw T* (\002\024\021\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\020\024\021\024\r\022\017 \027\026\031\004\027\024-\023\036\ \007\026\020\024\020\017\004\036\f\022\017\b \022\026\007\030\024\r )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 504.6396 56.0378 Tm (113)Tj ET endstream endobj 856 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.192 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\024\035\024\f\021\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017-\007\024\f\021\031\023\026 \016\r\035\016\036\021\f\016 \027\ \036\023\030\036\030\t\r\027\t\005 )Tj 0.437 Tw 0 -1.218 TD (\n\024\027\017\021\024\030\017\027\020 \f\024\f\021\024\016\027\017\016 \ \023\026\006\017\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034\033 )Tj 0.131 Tw T* (\r\t\023\024\035\027\036\027\017\016 \022\024\027\021\030\024\035\034\027\ \t\b \017\f\f\035\036\007\024\r\026\027\017\005, \004\021\024 \022\030\026\ \005\027\036 )Tj 0.187 Tw T* [(\026\021\030\031\007\027\017\021\036\035\034\027\024 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.327 0 Td [(\023\036\030\036\007\024\r\t\b )0.5(\233\204\233. )0.6(\212\026\027\027\t\005 )0.5(\023\024\007\b\024\007 )]TJ 0.257 Tw -8.327 -1.218 Td [(\016\r\035\016\036\021\f\016 \f\022\024\030\036\036 \017\f\022\035\033\004\ \036\027\017\036\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\024\002\013\036\023\030\017\027\026\027\027\t\b )Tj 0.052 Tw T* (\023\030\026\r\017\035 \b\017\030\031\030\020\017\004\036\f\022\024\020\024\ \035\036\004\036\027\017\016 \200\002\217\215\025. \215\030\017\n\036\027\ \036\027\017\036 )Tj 0.307 Tw 0 -1.218 TD (\220\027\007\024\r\017\007\036\024\b\017\030\031\030\020\017\004\036\f\022\ \017\b \021\036\b\027\024\035\024\020\017\005, \023\024\r\024\035\016\033\ \013\017\b )Tj 0.097 Tw 0 -1.218 TD (\023\030\024\r\036\f\021\017 \007\036\021\026\035\034\027\t\005 \024\f\n\ \024\021\030 \002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \017\ )Tj /Span<>> BDC ( )Tj EMC (\n\026)Tj 0 Tw (-)Tj 0.078 Tw T* (\035\024\020\024 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\235\024\030\n\017\030\024\r\026\021\034 \007\017\r\036\030\f\017\024\027\ \027\031\033 \022\024\035\024\f\021\024\n\031, )Tj 0.197 Tw T* (\017\n\036\036\021 \002\036\031\f\035\024\r\027\t\036 \023\030\036\017\n\ \031\013\036\f\021\r\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\024\035\017\030\024\r\026\027)Tj 0 Tw (-)Tj T* (\027\024\n \200\002\217\215\025 [34].)Tj 0.291 Tw T* (\221\030\026\027\f\035\033\n\017\027\026\035\034\027\024\036 \031\001\017\ \r\026\027\017\036 \030\026\027\t \023\030\016\n\024\005 \022\017\001\022\ \017, )Tj 0.36 Tw 0 -1.218 TD (\024\f\024\002\036\027\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024\r\t\b \233\204\233, \023\030\036\007\f\021\026\r\ \035\016\036\021 \f\024\002\024\005 )Tj 0.032 Tw 0 -1.218 TD [(\021\036\b\027\017\004\036\f\022\017 )0.6(\f\035\024\032\027\031\033 )0.5(\n\026\027\017\023\031\035\016\006\017\033 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 15.607 0 Td [(\r\t\t\r\026\036\021 )0.5(\024\023\030\036)]TJ 0 Tw (-)Tj 0.14 Tw -15.607 -1.218 Td (\007\036\035\036\027\027\t\036 \021\030\031\007\027\024\f\021\017 \007\026\ \032\036 \031)Tj /Span<>> BDC ( )Tj EMC (\024\023\t\021\027\t\b \f\023\036\006\017\026\035\017\f\021\024\r. )Tj 0.246 Tw 0 -1.218 TD (\025\030\024\n\036 \021\024\020\024, \004\021\024 \007\026\027\027\026\016\ \n\026\027\017\023\031\035\016\006\017\016 \f\023\024\f\024\002\f\021\r\ \031\036\021 )Tj 0.12 Tw T* (\007\024\023\024\035\027\017\021\036\035\034\027\024\005 \002\026\022\021\ \036\030\017\026\035\034\027\024\005 \022\024\027\021\026\n\017\027\026\006\ \017\017 \022\035\036\021)Tj 0 Tw (-)Tj 0.187 Tw T* (\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\r \021\ \026\026, \r\t\023\024\035\027\036\027\017\036 \036\036 \023\030\026\022\ \021\017)Tj 0 Tw (-)Tj 0.129 Tw T* (\004\036\f\022\017 \r\f\035\036\023\031\033, \022\026\022 \023\030\026\r\ \017\035\024, \027\036 \023\024\r\024\035\016\036\021 \007\024\002\017\021\ \034\f\016 )Tj 0.055 Tw T* (\022\026\004\036\f\021\r\036\027\027\024\005 \026\007\026\023\021\026\006\ \017\017 \f\035\024\036\r \f\021\036\027\022\017 \022\017\001\022\017. \210\ \007\027\017\n )Tj 0.069 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\026\030\017\026\027\021\024\r \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \021\026\022\021\017\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022)Tj 0 Tw (-)Tj -0.016 Tw T* (\021\017\r\027\t\b \200\002\217\215\025 \016\r\035\016\036\021\f\016 \024\ \021\022\026 \024\021 \031\001\017\r\026\027\017\016 \030\026\027\t \022\ \017\001)Tj 0 Tw (-)Tj 0.13 Tw T* (\022\017. \207\024\020\026\021\024\036 \022\030\024\r\024\f\027\026\002\032\ \036\027\017\036 \023\030\016\n\024\005 \022\017\001\022\017 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.229 Tw T* (\022\035\033\004\036\027\027\024\n \023\026\f\f\026\032\036 \021\024\035\ \f\021\024\022\017\001\036\004\027\024\020\024 \f\024\007\036\030\032\017\ \n\024\020\024 )Tj 0.216 Tw T* (\004\036\030\036 \024\027\031 \200\002\217\215\025 \023\024\r\024\035\ \016\036\021 \007\024\002\017\021\034\f\016 \026\032\017\r\035\036\027\017\ \016 )Tj 0.086 Tw T* [(\007\036\235\036\022\021\026 )0.5(\n\036\027\036\036 )0.5(\274 \036\036 )0.5(\024\022\030\031\032\027\024\f\021\017 )0.5([1,5]. \221\026\022 )0.5(\032\036 \024\021\n\036)]TJ 0 Tw (-)Tj 0.198 Tw T* (\004\026\033\021\f\016 \030\026\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\n \f\021\026\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b )Tj -0.004 Tw T* (\030\036\f\023\024\027\007\036\027\021\024\r, \023\030\036\007\023\024\004\ \017\021\026\033\013\017\b \031\001\017\r\026\021\034 \007\036\235\036\022\ \021 \023\030\016)Tj 0 Tw (-)Tj 0.134 Tw T* (\n\024\005 \022\017\001\022\017 \(t \022\030\017\021\036\030\017\005 \222\ \021\034\033\007\036\027\021\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.134 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\). \204\036\027\036\036 )Tj 0.033 Tw T* [(\024\023\t\021\027\t\036 )0.5(\b\017\030\031\030\020\017 \004\026\013\036 )0.5(\023\030\036\007\023\024\004\017\021\026\033\021 )0.5(\027\036 \031\001\017\r\026\021\034 )0.5(\027\036)]TJ 0 Tw (-)Tj T* (\007\036\f\021\030\031\022\021\017\r\027\t\036 \200\002\217\215\025.)Tj 0.286 Tw T* (\233\035\036\n\036\027\021\024\n \025\024\027\006\036\023\006\017\017, \023\ \024\r\024\035\016\033\013\017\n \f\027\017\017\021\034 \022\024\027)Tj 0 Tw (-)Tj 0.445 Tw T* (\021\026\n\017\027\026\006\017\033 \022\035\036\021\004\026\021\024\004\027\ \t\b \023\030\024\f\021\030\026\027\f\021\r \021\026\026 \004\036\030\036\  )Tj 0.086 Tw T* (\030\026\027\031 \023\030\016\n\024\005 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \031\n\036\027\034\001\017\021\034 \r\036\030\024\016\ \021\027\024\f\021\034 )Tj 0.417 Tw T* (\030\026\r\017\021\017\016 \017\027\235\036\022\006\017\024\027\027\t\b\ \024\f\035\024\032\027\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025, )Tj 0.152 Tw T* (\016\r\035\016\036\021\f\016 \007\017\f\021\026\035\034\027\024\036 \024\ \021\n\t\r\026\027\017\036 \024\021\022\035\033\004\036\027\027\024\005 \ \004\026\f\021\017 )Tj -0.008 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. \203\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \211\204\215 \017\n\036\033\021\f\016 \f\021\ \026\021\017\f\021\017)Tj 0 Tw (-)Tj 0.039 Tw T* (\004\036\f\022\017 \027\026\004\017\n\t\036 \030\026\035\017\004\017\016\ \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \f\023\024\f\024\002\026 \024\021\n\t\r\026)Tj 0 Tw (-)Tj -0.009 Tw T* (\027\017\016 \023\030\016\n\024\005 \022\017\001\022\017 \(\022\030\017\021\ \036\030\017\005 \215\017\030\f\024\027\026 \245)Tj 0 Tw 5.83 0 0 5.83 237.1827 265.3958 Tm (2)Tj 10 0 0 10 240.0977 262.0658 Tm (, )Tj /T1_1 1 Tf 0.409 0 Td (p)Tj /T1_0 1 Tf -0.009 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0001\). )Tj 0.307 Tw -17.333 -1.218 Td (\203\026\002\035\033\007\026\036\n\026\016 \020\036\021\036\030\024\020\036\ \027\027\024\f\021\034 \f\024\024\021\027\024\001\036\027\017\016 \r\t\002\ \024\030\026 )Tj 0.145 Tw T* (\f\023\024\f\024\002\026 \024\021\n\t\r\026\027\017\016 \n\036\032\007\031\ \211\204\215 \027\036 \016\r\035\016\036\021\f\016 \f\021\026\021\017\f\ )Tj 0 Tw (-)Tj 0.127 Tw T* (\021\017\004\036\f\022\017 \027\026\004\017\n\024\005 \(\022\030\017\021\ \036\030\017\005 \025\030\026\n\036\030\026 V)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34, \f\035\026)Tj 0 Tw (-)Tj 0.191 Tw T* (\002\024\005 \f\017\035\t\). \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \211\204\215 \027\026\004\017\n\024 \030\ \026\035\017\004\026\033\021\f\016 )Tj -0.025 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \024\021\n\t\r\026\027\017\016 \023\030\016\n\ \024\005 \022\017\001\022\017 \004\036\030\036 \f\021\024\n\031 \(\026\027\ )Tj 0 Tw (-)Tj 0.105 Tw T* (\021\036\020\030\026\007\027\024\) \f)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \023\030\036\024\002\035\026\007\026\027\017\036\n \027\026\ )Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 \(\022\030\017\021\036\030\017\005 )Tj -0.004 Tw T* (\215\017\030\f\024\027\026 \245)Tj 0 Tw 5.83 0 0 5.83 113.9657 180.1498 Tm (2)Tj 10 0 0 10 116.8807 176.8198 Tm (, )Tj /T1_1 1 Tf 0.414 0 Td (p)Tj /T1_0 1 Tf -0.004 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,007 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \). \203\026)Tj /Span<>> BDC ( )Tj EMC (4 )Tj 0.206 Tw -5.015 -1.218 Td (\211\204\215 \030\036\f\023\024\027\007\036\027\021\t \024\021\007\026\033\ \021 \023\030\036\007\023\024\004\021\036\027\017\036 \030\036\021\030\024\ \020\030\026\007)Tj 0 Tw (-)Tj -0.041 Tw T* [(\027\024\n\031 )0.5(\024\021\n\t\r\026\027\017\033 )0.6(\024\021\022\035\033\004\036\027\027\024\020\024 )0.6(\024\021\007\036\035\026 )0.5(\021\024\035\f\021\024\005 )0.5(\022\017\001\022\017 )]TJ 0 Tw T* (\(\004\036\030\036 \026\027\026\035\034\027\t\005 \022\026\027\026\035\)\ \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.414 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \007\017\f\022\031\f\f\017\024\027\027\t\ \b \026\f\023\036\022\021\024\r \024\002)Tj 0 Tw (-)Tj 0.282 Tw T* [(\f\031\032\007\026\036\n\024\005 \023\030\024\002\035\036\n\t \016\r\035\ \016\036\021\f\016 )0.5(\027\036\024\002\b\024\007\017\n\024\f\021\034 \r\t)]TJ 0 Tw (-)Tj 0.52 Tw T* (\023\024\035\027\036\027\017\016 \021\026\022\024\005 \021\030\026\r\n\026\ \021\017\004\027\024\005 \n\026\027\017\023\031\035\016\006\017\017, \022\ \026\022 )Tj 0.308 Tw T* (\030\031\021\017\027\027\024\036 \023\026\030\026\030\036\022\021\026\035\ \034\027\024\036 \017\035\017 \023\030\036\f\026\022\030\026\035\034\027\ \024\036 \007\030\036)Tj 0 Tw (-)Tj 0.229 Tw T* (\027\017\030\024\r\026\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 [35\22637]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\n\036\033\021\f\016 )Tj 0.193 Tw 23.244 64.543 Td (\f\024\024\002\013\036\027\017\016 \024)Tj /Span<>> BDC ( )Tj EMC (\027\036\220\235\235\036\022\021\017\r\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\026\004\026\f\021\031\033 \027\036\026\007\036\022)Tj 0 Tw (-)Tj 0.067 Tw 0 -1.218 TD (\r\026\021\027\024\n \017\f\023\024\035\027\036\027\017\017 \007\026\027\ \027\024\005 \n\026\027\017\023\031\035\016\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\t\b \233\204\233 [38\22640].)Tj 0.062 Tw 0 -1.218 TD (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \007\035\016 15 \030\036\f\023\024\027\007\036\027\021\024\r \024\ \030\017)Tj 0 Tw (-)Tj 0.248 Tw 0 -1.218 TD (\036\027\021\017\030\026\n\017 \031\f\021\026\027\024\r\022\017 \023\026\ \030\026\030\036\022\021\026\035\034\027\t\b \007\030\036\027\026\032\036\ \005 \016\r)Tj 0 Tw (-)Tj 0.298 Tw 0 -1.218 TD (\035\016\035\017\f\034 \f\036\007\026\035\017\013\027\t\036 \002\031\020\ \030\t, \r\t\f\024\021\026 \023\026\035\034\006\026 \017\035\017 \032\036\ )Tj 0.258 Tw 0 -1.218 TD (\020\035\031\002\017\027\026 \031\f\021\026\027\024\r\022\017 \n\036\027\ \036\036 7 \f\n. \211\022\026\026\027\027\t\005 \023\024\007\b\024\007 \ )Tj 0.317 Tw 0 -1.218 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\036 \007\030\036\027\026\032\036\005, \r\036\ \030\024\016\021\027\036\036 \r\f\036\020\024, \027\036 \002\031\007\036\ \021 )Tj 0.073 Tw T* (\024\002\036\f)Tj /Span<>> BDC ( )Tj EMC 1.91 0 Td (\023\036\004\017\r\026\021\034 \007\024\035\032\027\024\005 \007\030\036\ \027\026\032\027\024\005 \235\031\027\022\006\017\017, \004\021\024, \027\ \036)Tj 0 Tw (-)Tj 0.071 Tw -1.91 -1.218 Td (\f\024\n\027\036\027\027\024, \016\r\035\016\036\021\f\016 \023\030\036\007\ \017\022\021\024\030\024\n \030\026\r\017\021\017\016 \024\f\035\024\032\ \027\036)Tj 0 Tw (-)Tj 0.039 Tw T* (\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\035\026\f\021\017 \022\035\036\021\004\026\021\024\004\027\t\b \ \023\030\024\f\021\030\026\027\f\021\r \021\026\026, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024)Tj 0 Tw (-)Tj 0.444 Tw T* (\002\036\027\027\024\f\021\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\017\b \030\026\027\036\027\017\016\b )0.5(\r\027\036\002\030\033\001\017\027\027\024\020\024 )]TJ 0 Tw T* (\024\021\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017 \(\217\ \017\f.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.438 Tw T* [(\202\027\026\035\017 \030\036\031\035\034\021\026\021\024\r )0.5(\026\027\022\036\021\017\030\024\r\026\027\017\016 \r\t\016\r\017\035 \026\ \002\f\024)]TJ 0 Tw (-)Tj 0.268 Tw T* [(\035\033\021\027\031\033 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\023\024\007\b\024\007\024\r )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 15.835 0 Td [(\r\t\002\024\030\031 )0.5(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.483 Tw -15.835 -1.218 Td [(\007\024\r\026\021\036\035\034\027\024\f\021\017 )0.6(\r\t\023\024\035\027\036\027\017\016 )0.6(\220\035\036\n\036\027\021\024\r )0.5(\025\024\027\006\036\023\006\017\017 )]TJ 0.036 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.242 0 Td [(\r\f\036\b )0.5(\211\204\215. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 6.306 0 Td [(\220\021\024\n )0.5(49 )0.5(\030\036\f\023\024\027\007\036\027\021\024\r )0.6(\024\f\031\013\036\f\021\r\035\016)]TJ 0 Tw (-)Tj 0.287 Tw -7.549 -1.218 Td (\033\021 \023\026\030\026\030\036\022\021\026\035\034\027\024\036 \007\030\ \036\027\017\030\024\r\026\027\017\036 \023\024\f\035\036 \031\001\017\r\ \026\027\017\016 )Tj 0.135 Tw T* (\035\026\023\026\030\024\021\024\n\027\024\005 \030\026\027\t, \004\021\024\ \027\036 \023\024\r\024\035\016\036\021 \024\f\031\013\036\f\021\r\035\ \016\021\034 )Tj -0.021 Tw T* (\022\024\027\021\030\024\035\034 \031\f\021\026\027\024\r\022\017 \007\030\ \036\027\026\032\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\031\f\035\024\r\035\017\r\026\036\021 \r\t\f\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\022\017\036 \030\017\f\022\017 \023\024\r\030\036\032\007\036\027\017\016\ \032\017\027\036\027\027\024 \r\026\032\027\t\b \026\027\026\021\024\n\ \017)Tj 0 Tw (-)Tj T* (\004\036\f\022\017\b \f\021\030\031\022\021\031\030 \021\026\026 \(\217\ \017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.316 Tw T* (\211\004\017\021\t\r\026\016 \r\t\f\024\022\031\033 \021\030\026\r\n\026\ \021\017\004\027\024\f\021\034 \023\026\030\026\030\036\022\021\026\035\034\ \027\024)Tj 0 Tw (-)Tj 0.257 Tw T* (\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\024\n\036\ \032\027\024\f\021\027\t\n \007\024\f\021\031\023\024\n, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.108 Tw T* [(\032\036 )0.5(\030\017\f\022\017 )0.6(\016\021\030\024\020\036\027\027\024\020\024 )0.5(\023\024\r\030\036\032\007\036\027\017\016 )0.5(\024\030\020\026\027\024\r )0.6(\n\026\035\024\020\024 )]TJ 0.118 Tw T* (\021\026\026, \007\026\027\027\026\016 \n\026\027\017\023\031\035\016\006\ \017\016, 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0 0 1 k /GS1 gs /T1_1 1 Tf ( \205\200\027\026\020\023\022\007\027\024\n\031\027 \022\016\031\240\032\ \020\255\027\025\022\027 \b\f\r\240\022\025\013 \240\022\f\020\023\027)Tj 0 Tw (-)Tj 0 -1.2 TD (\032\020\f\017\025\031\235 \r\024\023\020\025\031\021\n\022 \033\020\032\ \020\032\027\n\023\020\f\017\025\013\200 \030\032\027\025\020\255\027\235\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.041 Tw T* [(F)-16(igure 6)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Schematic rep)46(resentation of)]TJ /Span<>> BDC ( )Tj EMC [(the dep)13(th of)]TJ /Span<>> BDC ( )Tj EMC (the bilateral )Tj 0 Tw T* (installation of)Tj /Span<>> BDC ( )Tj EMC (pararectal drains)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td 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$n'y+A2tVg1R'ؐ;6]F~W_'=e(`-huƝ/D >y'[QEQEPҪEQEQEQE!0䗎l \gv$bE[!*QEQE’`)*wk( dd^"<6/')<Q.Ȑ-;Q}z((ӪEQEQEQEk۱#8:&GI.p["7 x-z̶z7!!#W((+Y\3iӶGv|Ƌ^PY` $~-΂seiU #y+qks:=@Ӫ- }QEժEQEQEQE&xu|FϩMQEQEQXQ6M1{(Ot5\&_^r\^J; GFMU`J0EE U6jKݏO2+!D%i( (s44eI׉O*yʐSSjݙs)yn1Ds Υm ḧz˹ݬR,m!Ai>EE|+i@B[STRq]W JVGU.ܴ/DsrP=xF{vkgviM!4m`8S%;Koh`S-uJĐmMUy!ج՗քgp;2 "袊ЪEQEQEQJ(ޕjv-Dp87v6H~նP2aN8}iCuhEQERΦ֌Z[~h]!G^ݑo&r7C4):@G@FNq(NVׅ 8]ZYhAmpg)i%K;= tuzXjn1+&Qµvg"\Fk֍A>=zZSqoh(ꮷ#U9N,%L}h@rAp0f[BP)JFAKL3->* =A;h#)ڮw{%4̋*Kpj(}Y )ӕYn|sA\)<{ m{LQEQI4.\f?ʣdOiNQEѪEQEQERԎY#ѓuKpHPϫٚHsceɳ7in\s'[I=((%J 2I4qMI-v=9;2`!zN4VdMtzcY;vFz=\QEQ^;Ů5"/) 8P*kp"Lͼl[C;(Q;3gLɅ-u(79(*GX; |:n> e_u5cs'ljmqiuK#e&hjm d'7vBCe1ջgOzLZ[}2[0zFz]jybO ߋ\%{\^ $osW4QErlqcNdUq$9MΆ~ni uPҪEQEQEWW2|t 7G(x'vEQE0}imT)$IKmZiW"P.#SΎ'Sm̥'D$^(((xIrhԶZfC%D6QHA M0ɅH$ea{yJ{!"S2D4PKYyV Q}۲[(3!JO–?65ݖcR^%cKiZ{ԇ=ΓNxv3.ZKBTc(yA(+Lvv+-XJIҖ?s/Btt%3QEӪEQEQEQEQEQH'뢬vՎ'wrAe$H#7ieRi (((5/Z^JۀfXH ,B;ȯN'R[S@|4za%=꭭s>4"b)2MLGBqi#g '^IJn^۶œy׈?q=j l+,\qHV9G{Ǡj;Q;%Ӝ-uom-QBJHfmSm%1nXgMwQERu~dxAfsYi^;SPԪEQEQEQEQERLoFW.Rs:@#}}L$S of;-2d%(%ƽQEQEQEQ]RGȒe8pRN)fv[.qt 9=!Jbʆp{xv(Z(((((jsXBl+ poigp (dE#<,,)znTUnݣ{Niy֐-$)*x WQE&:hIJe7.OyWe9Q@תEQEQEQEQEfjn2㨶n!.Hczjv|ۋYB[m ` ((((+:fȵG1|J7~B=MՏ$6杼kҮ.:ӸM iq6Zq%+m`)  ƷqeYf;*K]v)ZhWh+'R èyZL %҄`mz]ЪEQEQEQEQEQEQEQEQEQEQKzKuSW{C)yΎy>3_gVzwLkn6fkќ7qǼoZ(((ѪEQEQEQEQEQEQEQEQEQEQEa]%ohK&4qLks#xm gwAlM?-!gf-?:ꎚr((ҪEQEQEQEQEQEQEQEQEQEQEڠޠo6eܤ$ioJ=v\/%O3vV7xуъp(( endstream endobj 941 0 obj <>stream User endstream endobj 855 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.17 Tw 10 0 0 10 42.5197 724.8299 Tm (\022\026\027\026\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\032\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\007\ \036\035\026 \023\030\016\n\024\005 \022\017\001\022\017. )Tj 0.036 Tw 0 -1.218 TD (\215\030\017\n\036\027\036\027\017\036 \032\036 \220\027\007\024\f\022\024\ \023\017\004\036\f\022\017\b \n\036\021\024\007\017\022 \(\030\017\020\017\ \007\027\026\016 )Tj -0.02 Tw T* (\023\030\024\022\021\024\f\022\024\023\017\016, \235\017\002\030\024\022\ \024\035\024\027\024\f\022\024\023\017\016\), \027\036\f\n\024\021\030\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.514 Tw T* (\f\024\022\031\033 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(\030\036\027\021\020\036\027\024\035\024\020\017\004\036\f\022\017\036 \n\ \036\021\024\007\017\022\017 \(\030\036\027\021\020\036\027\024\020\030\026\ \235\017\016 )Tj 0.09 Tw T* [(\002\030\033\001\027\024\005 )0.6(\023\024\035\024\f\021\017, )0.5(\006\017\f\021\024\031\030\036\021\030\024\020\030\026\n\n\026, )0.5(\r\031\035\034\027\036\030\024\020\030\026)]TJ 0 Tw (-)Tj T* (\235\017\016, \022\024\027\021\030\026\f\021\027\026\016 \023\030\024\022\ \021\024\020\030\026\235\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007.\) [10,11].)Tj -0.052 Tw T* (\200\027\031\021\030\017\023\030\024\f\r\036\021\027\t\036 \n\036\021\024\ \007\t \007\017\026\020\027\024\f\021\017\022\017 \023\024\r\030\036\032\ \007\036\027\017\005 )Tj -0.002 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017 \(\023\030\024\022\021\024-,\ \030\036\022\021\024-, \235\017\002\030\024\022\024\035\024\027\024\f\022\ \024\023\017\016\) )Tj -0.055 Tw 0 -1.218 TD (\023\030\017\n\036\027\016\033\021 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(\f\035\024\032\027\024\005 \n\036\007\017\022\024-)Tj 0.03 Tw T* (\021\026\022\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\ \036, \b\026\030\026\022\021\036\030\027\024\005 \007\035\016 \023\036\030\ \036\007\024\r\t\b )Tj 0.215 Tw T* (\220\021\026\023\024\r. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\024\021\031 \017\f\023\024\035\027\036\027\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024)Tj 0 Tw (-)Tj 0.22 Tw T* [(\022\031\033 \007\017\026\020\027\024\f\021\017\004\036\f\022\031\033 )0.5(\006\036\027\027\024\f\021\034, \026\027\024\f\022\024\023\017\016 \030\036\ \f\023\024\027)]TJ 0 Tw (-)Tj 0.154 Tw T* (\007\036\027\021\026\n\017 \017\f\023\024\035\034\031\036\021\f\016 \022\ \030\026\005\027\036 \030\036\007\022\024, \r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\017 )Tj -0.033 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\036\007\024\r\t\b \233\204\233. \207\024\035\036\036 )0.5(\004\026\f\021\024\036 \023\030\017\n\036\027\036\027\017\036 )0.5(\007\026\027\027\024\020\024 )]TJ 0.083 Tw T* (\n\036\021\024\007\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215, \r\036\030\024\016\021\027\024, \023\024\r\024\035\017\021\ \027\026\004\017\021\036\035\034)Tj 0 Tw (-)Tj 0.06 Tw T* (\027\024 \f\027\017\017\021\034 \004\026\f\021\024\021\031 \023\024\007\ \027\036\005 \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\ \025, \004\021\024, )Tj 0.216 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\033 \024\004\036\030\036\007\034, \031\n\036\027\034\001\017\021\ \022\024\035\017\004\036\f\021\r\024 \024\f\035\024\032\027\036\027\017\ \005 )Tj 0 Tw T* (\031)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \022\026\021\036\020\024\030\017\017 \023\024\f\021\030\ \026\007\026\r\001\017\b.)Tj 0.124 Tw T* (\217\036\f\023\024\027\007\036\027\021\t \021\026\022\032\036 \024\021\n\ \036\004\026\033\021, \004\021\024 \021\026\022\017\036 \n\036\021\024\007\ \t \022\026\022 )Tj 0.09 Tw T* (\030\036\027\021\020\036\027\024\020\030\026\235\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\034\021\030\026\r\031\022\024\r\024\036 \017\f\f\035\036\007\024\ \r\026\027\017\036 \n\026)Tj 0 Tw (-)Tj 0.098 Tw T* (\035\024\220\235\235\036\022\021\017\r\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \200\002\217\215\025, \021\026\ \022 \022\026\022 \023\024\r\024)Tj 0 Tw (-)Tj -0.043 Tw T* [(\035\016\033\021 )0.5(\026\023\024\007\024\030\017\021\034 )0.5(\023\024\r\030\036\032\007\036\027\017\036 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.5(\021\024\035\034\022\024 )]TJ 0.023 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\f\r\036\027\027\t\n \023\030\017\027\026\022\026\n. \215\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\007\017\027 \030\036\f\023\024\027\007\036\027\021 )Tj 0.298 Tw T* (\024\002\030\026\021\017\035 \r\027\017\n\026\027\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\n\024\032\027\024\f\021\034 \017\f\023\024\035\034\024\r\026\027\ \017\016 )Tj 0.436 Tw T* [(\n\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\024\005 )0.6(\021\024\n\024\020\030\026\235\017\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 16.99 0 Td (\007\017\026\020\027\024\f\021\017\022\036 )Tj 0.105 Tw -16.99 -1.218 Td [(\200\002\217\215\025, )0.5(\022\024\021\024\030\026\016 )0.6(\024\020\030\026\027\017\004\036\027\026, )0.5(\022\026\022 )0.5(\017\r\036\f\021\027\024, )0.6(\027\026\035\017\004\017\036\n )]TJ 0.033 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\b \023\024\f\021\030\026\007\026\r\001\036\020\024 \ \235\036\030\030\024\n\026\020\027\017\021\027\t\b \017\027\024\030\024\007\ \027\t\b )Tj 0 Tw T* (\021\036\035.)Tj 0.413 Tw T* (\203\026\017\002\024\035\036\036 \031\007\024\002\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\023\030\024\f\021\030\026\027\036\027\027\t\n \n\036\021\024\007\ \024\n )Tj 0.271 Tw T* (\007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\025, \024\f\024\ \002\036\027\027\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\b \(\r\036\030\b)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\036- \017)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\ \007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017\) \030\026)Tj 0 Tw (-)Tj 0.095 Tw T* (\027\036\027\017\016\b, \016\r\035\016\036\021\f\016 \022\024\n\023\034\033\ \021\036\030\027\026\016 \021\024\n\024\020\030\026\235\017\016, \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 )Tj 0.202 Tw T* [(\024\021\f\031\021\f\021\r\017\016 )0.6(\027\036\024\002\b\024\007\017\n\024\f\021\017 )0.5(\f\023\036\006\017\026\035\034\027\024\005 )0.6(\023\024\007\020\024\021\024\r\022\017 )]TJ 0.049 Tw T* (\023\026\006\017\036\027\021\026, \f\022\024\030\024\f\021\017 \r\t\023\024\ \035\027\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\017 \030\036\031\035\034\021\026\021\026 )Tj 0.164 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\016 \(\r \021\024\n \004\017\f\035\ \036 \007\017\f\021\026\027\006\017\024\027\027\024\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 )Tj 0.118 Tw T* (\r\024\n\024\032\027\024\f\021\017 \007\017\026\020\027\024\f\021\017\022\ \017 \f\024\004\036\021\026\027\027\t\b \023\024\r\030\036\032\007\036\027\ \017\005 )Tj 0.206 Tw T* ([12\22615]. \210\f\024\002\036\027\027\024 \r\t\f\024\022\024\005 \004\031\ \r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 \(\007\024 )Tj 0.14 Tw T* (97%\) \024\002\035\026\007\026\036\021 \022\024\n\002\017\027\026\006\017\ \016 \030\017\020\017\007\027\024\005 \023\030\024\022\021\024\f\022\024\ \023\017\017 )Tj 0.084 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\026\ \235\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \025\221)Tj /Span<>> BDC ( )Tj EMC (\227 \017\030\030\017\020\024)Tj 0 Tw (-)Tj 0.243 Tw T* (\020\030\026\235\017\016 [9]. \210\007\027\026\022\024 \024\f\027\024\r\027\ \t\036 \n\036\021\024\007\t \007\017\026\020\027\024\f\021\017\022\017 )Tj 0.445 Tw T* [(\200\002\217\215\025, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\r\017\007\031 )0.5(\f\r\024\017\b )0.5(\021\036\b\027\017\004\036\f\022\017\b )0.5(\024\f\024\002\036\027\027\024\f\021\036\005, )]TJ 0.102 Tw T* (\021\030\031\007\027\024\007\024\f\021\031\023\027\t \007\035\016 \023\030\ \017\n\036\027\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024\r\t\b \233\204\233, )Tj 0.039 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\024\002\036\027\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \007\017\027\026\n\017\004\027\024 \017\n\036\ \027\016\033\013\036\005\f\016 )Tj 0.247 Tw T* (\n\036\007\017\022\024-\021\026\022\021\017\004\036\f\022\024\005 \024\002\ \f\021\026\027\024\r\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \036\f\035\017 )Tj 0.33 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (2 \211\204\215 \024\f\027\024\r\027\t\n \n\036\021\024\007\024\n \007\017\ \026\020\027\024\f\021\017\022\017 \200\002\217\215\025 )Tj 0.435 Tw 23.244 64.543 Td (\016\r\035\016\036\021\f\016 \023\026\035\034\006\036\r\024\036 \030\036\ \022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036\ , \021\024 )Tj 0.184 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\b \031\030\024\r\027\016\b \024\021\ \n\036\004\026\036\021\f\016 \026\022\024\027\024\n\036\030\027\024\036\ )Tj 0.088 Tw T* (\007\024\n\017\027\017\030\024\r\026\027\017\036 \022\024\n\023\034\033\021\ \036\030\027\024\005 \021\024\n\024\020\030\026\235\017\017 \027\026\007\ \007\030\031)Tj 0 Tw (-)Tj T* (\020\017\n\017 \n\036\021\024\007\026\n\017 \017\f\f\035\036\007\024\r\026\ \027\017\016.)Tj 0.302 Tw T* (\210\023\030\036\007\036\035\036\027\027\t\036 \021\030\031\007\027\024\f\ \021\017 \023\030\036\007\f\021\026\r\035\016\036\021 \r\t\002\024\030 \021\ \026\022)Tj 0 Tw (-)Tj 0.231 Tw T* (\021\017\022\017 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036\027\017\016 \022\026\022 \027\036\007\036\f\021\030\031\022\ \021\017\r\027\t\b )Tj 0.366 Tw 0 -1.218 TD (\(\n\036\027\036\036 \274 \024\022\030\031\032\027\024\f\021\017 \022\017\ \001\022\017\), \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.228 Tw 0 -1.218 TD (\027\t\b \200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \233\204\233 \r\027\036 \026\r\017\f\017\n\ \024\f\021\017 \024\021 )Tj 0.216 Tw T* (\211\204\215. \215\030\036\007\035\024\032\036\027\027\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (1971 \020\024\007\031 4D)Tj /Span<>> BDC ( )Tj EMC (\227 \022\024\027\006\036\023\006\017\016 )Tj 0.014 Tw T* (\(\025\024\027\006\036\023\006\017\016\), \f\024\f\021\024\016\013\026\016\ \017)Tj /Span<>> BDC ( )Tj EMC [(4 \220\035\036\n\036\027\021\024\r \(di)-15.9(ver)-10(sion)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj T* [(\024\021\r\036\007\036\027\017\036, debr)-37(idement)]TJ /Span<>> BDC ( )Tj EMC (\227 \b\017\030\031\030\020\017\004\036\f\022\026\016 \024\002\030\026\002\ \024\021\022\026, )Tj -0.021 Tw T* [(dr)-33(aina)-17(ge)]TJ /Span<>> BDC ( )Tj EMC [(\227 \007\030\036\027\017\030\024\r\026\027\017\036, dist)15(al w)-12(ashout)]TJ /Span<>> BDC ( )Tj EMC (\227 \007\017\f\021\026\035\034)Tj 0 Tw (-)Tj 0.041 Tw 0 -1.218 TD (\027\024\036 \024\021\n\t\r\026\027\017\036\) \f\021\026\035\026 \024\f\027\ \024\r\024\005 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\ \036\004\036)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD (\027\017\016 \030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\t\ \n \023\024\r\030\036\032\007\036\027\017\036\n )Tj 0.309 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017 [16]. \200)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \r\024\024\030\031\032\036\027\027\t\b\ )Tj 0.118 Tw T* (\022\024\027\235\035\017\022\021\026\b \007\026\027\027\024\005 \025\024\ \027\006\036\023\006\017\017 \023\030\017\007\036\030\032\017\r\026\036\021\ \f\016 \022\026\022 )Tj 0.115 Tw T* (\024\021\036\004\036\f\021\r\036\027\027\026\016, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\026\030\031\002\036\032\027\026\016 \r\024\036\027\027\026\016 \n\036\007\ \017\006\017\027\026 )Tj 0.081 Tw T* ([2,17\22620]. \210\007\027\026\022\024 \030\016\007 \017\f\f\035\036\007\ \024\r\026\021\036\035\036\005 \024\021\n\036\004\026\033\021 \027\036)Tj 0 Tw (-)Tj 0.223 Tw T* [(\024\002\b\024\007\017\n\024\f\021\034 )0.5(\r\t\002\024\030\026 \002\024\035\036\036 \017\002\017\030\026\021\036\035\ \034\027\024\020\024, )0.5(\023\036\030\f\024)]TJ 0 Tw (-)Tj 0.481 Tw T* (\027\017\235\017\006\017\030\024\r\026\027\027\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017\n\017\017\030\024\r\026\027\027\024\020\024 \023\024\007\ \b\024\007\026 )Tj 0.321 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC 1.014 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\n\031 )0.6(\035\036\004\036\027\017\033 )0.6(\200\002\217\215\025, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 15.829 0 Td (\024\f\024\002\036\027\027\024\f\021\017 )Tj 0.329 Tw -16.843 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \024\020\030\026\027\017\004\036\027\017\016 \ \030\036\f\031\030\f\024\r, \007\036\235\017\006\017\021\026 \r\030\036)Tj 0 Tw (-)Tj 0.236 Tw T* (\n\036\027\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \027\036\007\024\f\021\026\021\024\004\027\024\020\024\ \024\023\t\021\026 \f\023\036\006\017\026\035\017\f\021\024\r )Tj 0.071 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \211\204\215 [21\22625]. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \024\023\030\036\007\036\035\036\027\027\031\033 )Tj 0.024 Tw T* (\022\030\017\021\017\022\031 \r\t\t\r\026\036\021 \023\030\026\022\021\017\ \004\036\f\022\017 \022\026\032\007\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\035\036\n\036\027\021\024\r )Tj -0.008 Tw T* (\025\024\027\006\036\023\006\017\017, \026)Tj /Span<>> BDC ( )Tj EMC (\023\024\017\006\017\016 \220\022\f\023\036\030\021\024\r \r\026\030\034\ \017\030\031\036\021 \024\021 \023\024\035\027\024)Tj 0 Tw (-)Tj 0.129 Tw T* (\020\024 \024\021\022\026\026 \024\021 \027\036\022\024\021\024\030\t\b\ \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \007\024)Tj /Span<>> BDC ( )Tj EMC (\024\002\016\026\021\036\035\034\027\024\020\024 \017\b )Tj 0.216 Tw T* (\017\f\023\024\035\027\036\027\017\016, \035\017\002\024 \023\030\017\n\036\ \027\036\027\017\016 \017\r\036\f\021\027\t\b \023\024\007\b\024\007\024\ \r )Tj 0.113 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\027\024\n \r\026\030\ \017\026\027\021\036, \027\026\023\030\017\n\036\030, \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.144 Tw T* (\235\024\030\n\017\030\024\r\026\027\017\016 \022\024\035\024\f\021\024\n\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017-\007\024\f\021\031\023\026 \017\035\017 \r\t)Tj 0 Tw (-)Tj T* (\023\024\035\027\036\027\017\016 \007\017\r\031\035\034\f\017\017 \026\027\ \026\035\034\027\024\020\024 \032\024\n\026 [20,26\22630].)Tj -0.028 Tw T* [(\215\030\024\r\036\007\036\027\027\024\036 )0.6(\017\f\f\035\036\007\024\r\026\027\017\036 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035\024 )0.6(\r\t)]TJ 0 Tw (-)Tj 0.276 Tw T* (\f\024\022\031\033 \023\030\017\r\036\030\032\036\027\027\024\f\021\034 \ \030\036\f\023\024\027\007\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\024\002\016\026\021\036\035\034)Tj 0 Tw (-)Tj 0.408 Tw T* (\027\024\n\031 \024\021\022\035\033\004\036\027\017\033 \023\024\r\030\036\ \032\007\036\027\027\024\020\024 \031\004\026\f\021\022\026 \022\017\001\ \022\017, )Tj 0.017 Tw T* [(\024\007\027\026\022\024 )0.5(17/75 )0.5(\024\023\030\024\001\036\027\027\t\b )0.6(\017\035\017 )0.5(23 )0.5(\(14; )0.6(34\))]TJ /Span<>> BDC ( )Tj EMC 17.779 0 Td [(% )0.5(\f\004\017\021\026\033\021 )]TJ 0.242 Tw -17.779 -1.218 Td [(\r\024\n\024\032\027\t\n \017\f\022\035\033\004\017\021\034 )0.5(\r\t\023\024\035\027\036\027\017\036 \002\026\017\f\027\024\020\024 \220\ \035\036)]TJ 0 Tw (-)Tj 0.263 Tw T* (\n\036\027\021\026 \025\024\027\006\036\023\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \235\024\030\n\017\030\024\r\026\027\017\036 \007\017\r\036\030\f\017\ \024\027\027\024\005 )Tj 0.078 Tw T* (\022\017\001\036\004\027\024\005 \f\021\024\n\t. \203\036\024\002\b\024\007\ \017\n\024\f\021\034 \024\021\022\035\033\004\036\027\017\016 \023\026\f\ \f\026)Tj 0 Tw (-)Tj 0.155 Tw T* [(\032\026 )0.5(\022\017\001\036\004\027\024\020\024 )0.6(\f\024\007\036\030\032\017\n\024\020\024 )0.5(\027\036 )0.5(\r\t\t\r\026\036\021 )0.6(\f\024\n\027\036\027\017\016, )]TJ 0.087 Tw T* (\023\030\017\004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b \200\002\217\215\025\ \023\030\036\007\023\024\004\021\017\021\036\035\034)Tj 0 Tw (-)Tj 0.421 Tw T* (\027\t\n \030\036\001\036\027\017\036\n \016\r\035\016\036\021\f\016 \235\ \024\030\n\017\030\024\r\026\027\017\036 \023\036\021\035\036\r\024\005 \ )Tj 0.074 Tw T* [(\007\r\031\f\021\r\024\035\034\027\024\005 \022\024\035\024\f\021\024\n\t\ , )0.5(\004\021\024 \027\026\004\017\021\036\035\034\027\024 )0.5(\024\002\035\036\020\004\026\036\021 )]TJ 0.212 Tw T* (\021\036\004\036\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\020\024 \023\036\030\017\024\007\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024)Tj 0 Tw (-)Tj 1.771 Tw T* [(\f\035\036\007\031\033\013\017\036 )0.6(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024-\r\024\f\f\021\026\ \027\024\r\017\021\036\035\034\027\t\036 )]TJ 0.169 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\026. )0.5(\221\026\022\032\036, \023\030\017)]TJ /Span<>> BDC ( )Tj EMC [(\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b )0.5(\200\002\217\215\025 )]TJ 0.73 Tw T* (\007\024\023\031\f\021\017\n\024 \235\024\030\n\017\030\024\r\026\027\017\ \036 \023\036\021\035\036\r\024\005 \f\017\020\n\024\f\021\024\n\t )Tj 0.337 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027\017-\007\024\f\021\031\023\026, \004\021\024 \023\024\021\036\ \027\006\017\026\035\034\027\024 \n\024\032\036\021 \027\026\004\017)Tj 0 Tw (-)Tj 0.361 Tw T* (\021\036\035\034\027\024 \031\f\022\024\030\017\021\034 \023\030\024\006\ \036\f\f \r\024\f\f\021\026\027\024\r\035\036\027\017\016 \030\026\027\036\ \027\024)Tj 0 Tw (-)Tj 0.207 Tw T* (\020\024. \203\036\031\021\036\001\017\021\036\035\034\027\026\016 \f\021\ \026\021\017\f\021\017\022\026 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027\027\t\b )Tj 0.165 Tw T* (\024\f\035\024\032\027\036\027\017\005 \021\026\022\024\020\024 \007\024\ \f\021\031\023\026 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\r\024\n\024\032\027\024\f\021\034 \026\007\036\022)Tj 0 Tw (-)Tj 0.206 Tw T* (\r\026\021\027\024\005 \030\036\r\017\017\017 \002\030\033\001\027\024\005\ \023\024\035\024\f\021\017 \027\026\004\017\021\036\035\034\027\024 \f\ \024)Tj 0 Tw (-)Tj 0.186 Tw T* (\022\030\026\013\026\036\021 \036\020\024 \022\026\032\031\013\017\036\f\ \016 \023\030\036\017\n\031\013\036\f\021\r\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj -0.034 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\032\036\f\021\r\036\027\027\t\n\017 \024\f\022\024\035\024\004\ \027\t\n\017 \030\026\027\036\027\017\016\n\017 [31\22633]. )Tj 0.671 Tw T* [(\200\026\032\027\t\n )0.6(\031\f\035\024\r\017\036\n )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 )0.6(\007\017\r\036\030\f\017\024\027\027\024\005 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_2 1 Tf 25 0 0 25 503.8146 56.0378 Tm (111)Tj ET endstream endobj 757 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 758 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 759 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 760 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 761 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 950 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.045 Tw 10 0 0 10 70.8661 383.8459 Tm (\017\035\017 13 \(7; 23\) % \030\036\f\023\024\027\007\036\027\021\024\r\ \026\030\020\031\n\036\027\021\017\030\024\r\026\035\017 \r\t)Tj 0 Tw (-)Tj 0.046 Tw 0 -1.218 TD (\023\024\035\027\036\027\017\036 \007\026\027\027\024\020\024 \220\035\036\ \n\036\027\021\026 \025\024\027\006\036\023\006\017\017 \030\036\026\035\ \017\026\006\017\036\005 )Tj 0.105 Tw T* (\021\030\036\002\024\r\026\027\017\005 \030\036\020\035\026\n\036\027\021\ \017\030\031\033\013\017\b \007\024\022\031\n\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026)Tj 0 Tw (-)Tj T* (\027\017\005 \f\021\026\030\001\036\020\024 \n\036\007\017\006\017\027\f\ \022\024\020\024 \027\026\004\026\035\034\027\017\022\026.)Tj /T1_1 1 Tf 0.126 Tw 0 -2.436 TD [(\026\002\212\006\002\217 )0.5(\2369:)]TJ /T1_0 1 Tf [( \253\200\t\023\024\035\027\016\036\021\036 )0.5(\035\017 \200\t )0.5(\007\017\r\031\035\034\f\017\033 )0.5(\f\235\017\027\022)]TJ 0 Tw (-)Tj 0 -1.218 TD (\021\036\030\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017\ \023\030\016\n\024\005 \022\017\001\022\017?\273)Tj 0.716 Tw 23.244 7.307 Td (\025\024\035\017\004\036\f\021\r\024 \030\036\f\023\024\027\007\036\027\021\ \024\r, \023\030\036\007\023\024\004\017\021\026\033\013\017\b \r\t)Tj 0 Tw (-)Tj 0.141 Tw T* [(\023\024\035\027\036\027\017\036 )0.6(\007\017\r\031\035\034\f\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 10.364 0 Td [(\017\f\f\035\036\007\031\036\n\t\b )0.6(\211\204\215 )0.5(\f\021\026\021\017\f\021\017)]TJ 0 Tw (-)Tj 0.184 Tw -10.364 -1.218 Td (\004\036\f\022\017 \027\026\004\017\n\024 \027\036 \030\026\035\017\004\ \026\035\017\f\034 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\ \026\226)Tj 0 Tw T* (\205\030\017\n\026\027\026\226\216\024\035\021\024\027\026, )Tj /T1_2 1 Tf 8.247 0 Td (p)Tj /T1_0 1 Tf 0.301 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,15\). \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 )Tj 0.024 Tw -8.247 -1.218 Td (\007\017\r\031\035\034\f\017\016 \026\027\026\035\034\027\024\020\024 \f\ \235\017\027\022\021\036\030\026 \027\036 \016\r\035\016\036\021\f\016 \220\ \035\036\n\036\027)Tj 0 Tw (-)Tj 0.11 Tw T* (\021\024\n \025\024\027\006\036\023\006\017\017, \022\024\035\017\004\036\ \f\021\r\024 \030\036\f\023\024\027\007\036\027\021\024\r, \r\t\023\024\035\ \027\016)Tj 0 Tw (-)Tj 0.035 Tw T* (\033\013\017\b \036\036, \r)Tj /Span<>> BDC ( )Tj EMC (1,5 \(0,8; 2,8\) \030\026\026 \002\024\035\034\001\036, \004\036\n \f\004\ \017\021\026\033\013\017\b )Tj 0.387 Tw T* (\007\026\027\027\031\033 \n\026\027\017\023\031\035\016\006\017\033 \027\ \036\024\002\016\026\021\036\035\034\027\024\005 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (10\). )Tj 0.173 Tw T* [(\200\t\023\024\035\027\036\027\017\036 )0.5(\007\026\027\027\024\005 \n\026\027\017\023\031\035\016\006\017\017 )0.5(\017\035\017 )0.5(\024\021\022\026 \024\021 )0.5(\027\036\036 )]TJ 0.235 Tw T* (\027\036 \026\r\017\f\036\035 \024\021 \b\017\030\031\030\020\017\004\036\ \f\022\024\020\024 \f\021\026\032\026 \030\036\f\023\024\027\007\036\027\ \021\024\r )Tj 0.389 Tw T* (\(t-\022\030\017\021\036\030\017\005 \222\021\034\033\007\036\027\021\026\ , )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.389 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,77; \024\007\027\024\235\026\022\021\024\030\027\t\005 )Tj /T1_2 1 Tf -0.053 Tc 0.053 Tw T* [(AN)-33(O)-37(V)-11(A)]TJ /T1_0 1 Tf 0 Tc 0 Tw 2.533 0 Td (, )Tj /T1_2 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 213.3539 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.149 Tw 10 0 0 10 303.3071 188.9979 Tm (\215\030\017 \200\002\217\215\025 \007\017\026\020\027\024\f\021\017\004\ \036\f\022\017\005 \026\035\020\024\030\017\021\n \n\024\032\036\021 \r\022\ \035\033)Tj 0 Tw (-)Tj 0.392 Tw T* (\004\026\021\034 \022\026\022 \235\017\017\022\026\035\034\027\t\036 \n\ \036\021\024\007\t \017\f\f\035\036\007\024\r\026\027\017\016, \021\026\022\ )Tj -0.021 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\036 \017\027\f\021\030\031\n\036\027\021\026\ \035\034\027\t\036 \n\036\021\024\007\017\022\017. \215\026\035\034\006\036\ \r\024\036 )Tj 0.401 Tw T* (\017\f\f\035\036\007\024\r\026\027\017\036 \023\030\016\n\024\005 \022\017\ \001\022\017 \016\r\035\016\036\021\f\016 \f\026\n\024\005 \007\024)Tj 0 Tw (-)Tj 0.314 Tw T* [(\f\021\031\023\027\024\005 )0.6(\n\036\021\024\007\017\022\024\005, )0.5(\027\024 )0.5(\017\n\036\033\013\036\005 )0.5(\027\017\022\031\033 )0.6(\004\031\r\f\021\r\017)]TJ 0 Tw (-)Tj 0.204 Tw T* (\021\036\035\034\027\024\f\021\034 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\017\n \031\030\024\r\027\036\n \035\024\032\027\024\024\021\ \030\017\006\026\021\036\035\034\027\t\b )Tj 0.115 Tw T* (\030\036\031\035\034\021\026\021\024\r [8]. \200\026\032\027\031\033 \030\ \024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\007\017\026\020\027\024\f\021\017\022\036 \200\002\217\215\025 )Tj 0.362 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \024\020\030\026\027\017\004\036\027\027\t\b \ \030\036\f\031\030\f\024\r \n\024\032\036\021 \017\020\030\026\021\034 )Tj 0.436 Tw T* (\026\027\024\f\022\024\023\017\016, \023\024\r\024\035\016\033\013\026\016\ \r\t\016\r\017\021\034 \027\026\035\017\004\017\036 \022\030\024\r\017 \ )Tj 0.169 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036 \022\017\001\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \023\024\r\030\036\032\007\036\027\017\036 \026\027\ \026\035\034\027\024\020\024 )Tj ET q 70.866 178.639 221.102 108.456 re W n q /GS0 gs 221.1023475 0 0 108.5106011 70.8661504 178.5853609 cm /Im0 Do Q Q BT /T1_2 1 Tf 0.021 Tw 8 0 0 8 70.8661 169.0394 Tm (\004\032\022\026\027\007\020\025\022\027: \(1\) 4120; \(2\) 1230; \(3\) \ 1234; \(4\) 1240; \(5\) 1243; \(6\) )Tj 0.152 Tw 0 -1.2 TD (1324; \(7\) 1342; \(8\) 1423; \(9\) 1432; \(10\) 3120; \(11\) 3124; \(12\ \) )Tj 0 Tw T* (3412; \(13\) 0 \(\025\027 \030\032\027\025\022\032\r\005\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.469 Tw 9 0 0 9 70.8661 133.3701 Tm (\022\t\217\210\b\002\220 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \021\020\032\022\020\ \025\023\031\021 \033\031\024\f\027\030\031\021\020\023\027\f\017)Tj 0 Tw (-)Tj 0.131 Tw T* (\025\031\024\023\022 \030\032\027\025\022\032\031\021\020\025\022\t \004\ \202 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \204\023\020\033\020\200 )Tj 0 Tw T* (\204\021\020\n\r\020\006\022\022. )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.228 Tw T* [(F)-16(igure 5.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( Distr)-37(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the seq)14(uence of)]TJ /Span<>> BDC ( )Tj EMC (pararectal tissue )Tj 0.063 Tw T* [(drainag)12.1(e )0.5(op)13(tions )0.5(in )0.6(e)-15(xtraper)-36.9(itoneal )0.5(rectal )0.6(w)12(ounds )0.6(at )0.5(dif)-40(ferent )]TJ 0 Tw T* [(stag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(ev)16.1(acuation. A)14.1(t dif)-39.9(ferent stag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(ev)16.1(acuation. )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 9.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\020\024\033\032\027\030\027\f\027\025\022\027 \032\027\024\033\031\ \025\030\027\025\023\031\021 \033\031)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\030\031\021\020\023\027\f\017\025\031\024\023\022 \021\ \013\033\031\f\025\027\025\022\t \030\032\027\025\022\032\031\021\020\025\ \022\t \022)Tj /Span<>> BDC ( )Tj EMC (\r\213\022\021\020\025\022\t \032\020\025\013)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 9.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.299 0 Td [( D)-12.1(i)6.6(s)-14.8(t)-9.5(r)-39(i)4.6(b)-1.5(u)-4.8(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-1.9(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(n)-0.6(t)-32.9(s a)-9.1(c)2.3(c)2.8(o)-3(r)-3(d)-3(i)3.9(n)-0.6(g t)-2.9(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e s)0.5(e)-9.4(q)-3(u)-3.1(e)-7(n)-2.9(c)2.8(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(d)0.8(r)3.4(a)-6.3(i)3.9(na)-5.2(g)-6.8(e a)-5.1(n)-4.8(d w)2.3(o)-3.4(u)0.6(n)-4.8(d s)6.7(u)-4.8(t)-1.1(u)1.6(r)-39(i)4(n)-0.6(g)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8662 715.181 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 295.0532 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 340.4075 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 385.7618 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 431.1161 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6595 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8662 694.1118 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 694.1118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 295.0532 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.4075 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 385.7618 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 431.1161 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 694.1118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6595 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8662 682.6425 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 671.1813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 682.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 682.6425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 659.97 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 671.1813 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 246.8642 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 671.1813 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 659.97 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 659.72 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 648.2587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 659.72 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 659.72 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 659.72 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 648.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1162 637.0474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 648.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 246.8642 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 648.2587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 476.4705 648.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 637.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 636.7974 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 636.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 636.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 636.7974 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 625.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 625.3361 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 625.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 625.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 625.3361 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 614.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 613.8748 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1162 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 613.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 246.8642 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 613.8748 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 613.8748 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6595 602.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8662 602.4136 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 602.4136 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 295.0532 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 602.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 476.4705 602.4136 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 91.8389 706.5464 Tm (\200\002\217\f\r\240\002\004\003\r\f\001\b\002\217\003\001 \240\006\r\b\ \t\006\002\004\b\t\r)Tj /Span<>> BDC ( )Tj EMC (\237 )Tj 4.948 -1.2 Td (\210\230\t\004\b\t\r \006\004\b\013)Tj 15.463 0.6 Td (\255\t\214\002\f\013)Tj 5.637 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj 6.81 0 Td (\026\217\r\n\002)Tj -52.102 -2.034 Td (\017\206\233\r\214 \013\206\002\006\220\t)Tj /T1_4 1 Tf 24.313 0.001 Td (N)Tj /T1_1 1 Tf 5.603 -0.001 Td (22)Tj 5.669 0 Td (20)Tj 5.669 0 Td (18)Tj 5.947 0 Td (8)Tj 5.568 0 Td (68)Tj /T1_0 1 Tf -52.771 -1.433 Td (\212\030\036\027\017\030\024\r\026\027\017\036 \026\021\036\n \031\001\017\ \r\026\027\017\036)Tj /T1_2 1 Tf 24.376 0 Td (n)Tj /T1_0 1 Tf 5.846 0 Td (6)Tj 5.669 0 Td (5)Tj 5.669 0 Td (7)Tj 5.669 0 Td (1)Tj 5.596 0 Td (19)Tj /T1_2 1 Tf -29.224 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.611 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(11; 50\))Tj 5.919 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(6; 46\))Tj 5.419 0 Td (39)Tj /Span<>> BDC ( )Tj EMC (\(17; 64\))Tj 5.919 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(0; 53\))Tj 5.596 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(17; 39\))Tj -51.068 -1.433 Td (\211\001\017\r\026\027\017\036 \026\021\036\n \007\030\036\027\017\030\024\ \r\026\027\017\036)Tj /T1_2 1 Tf 24.34 0 Td (N)Tj /T1_0 1 Tf 5.632 0 Td (16)Tj 5.669 0 Td (15)Tj 5.669 0 Td (11)Tj 5.919 0 Td (7)Tj 5.596 0 Td (49)Tj /T1_2 1 Tf -29.224 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.611 0 Td (73)Tj /Span<>> BDC ( )Tj EMC (\(50; 89\))Tj 5.669 0 Td (79)Tj /Span<>> BDC ( )Tj EMC (\(54; 94\))Tj 5.669 0 Td (61)Tj /Span<>> BDC ( )Tj EMC (\(36; 83\))Tj 5.669 0 Td (87)Tj /Span<>> BDC ( )Tj EMC (\(47; 99\))Tj 5.846 0 Td (73)Tj /Span<>> BDC ( )Tj EMC (\(61; 83\))Tj /T1_2 1 Tf -51.068 -1.433 Td (p)Tj /T1_0 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 24.387 0 Td (p)Tj /T1_0 1 Tf 13.747 0 Td (0,59)Tj -38.134 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_2 1 Tf (V)Tj /T1_0 1 Tf ( \025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 24.386 0 Td (V)Tj /T1_0 1 Tf 11.244 0 Td (0,18\(-0,07; 0,39\))Tj -35.631 -1.433 Td (\231\026\027\f\t)Tj /T1_2 1 Tf 22.987 0 Td (f)Tj /T1_0 1 Tf (/\(1)Tj /Span<>> BDC ( )Tj EMC (\244 f\))Tj 27.804 0 Td (2,7)Tj /Span<>> BDC ( )Tj EMC (\(1,6; 4,6\))Tj /T1_2 1 Tf 7 0 0 7 70.8661 590.929 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ T* (\032\020\024\033\032\027\030\027\f\027\025\022\t.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 9 0 0 9 70.8661 563.225 Tm (\020\004\206\f\t\204\004 10.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\031\f\t \032\027\024\033\031\025\030\027\025\023\031\021, \021\013\ \033\031\f\025\t\005\212\022\200 \030\022\021\r\f\017\024\022\005 \024\203\ \022\025\n\023\027\032\020 \033\032\t\026\031\235 \n\022\213\n\022 \033\032\ \022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-5(0)-29.9(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.863 0 Td [( T)-6.4(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(p)-2.7(r)-2(o)-5.3(p)-9.1(o)-3(r)-41.9(t)-29.1(i)-1.4(o)-4(n o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(nt)-32.9(s p)-11.3(e)-6(r)-32.9(f)-13.4(o)-3(r)-18.6(m)1.4(i)3.9(n)-0.6(g a)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-10.9(c)-32.4(t)-2(a)-4.4(l s)4.4(p)-1.1(h)1.7(i)3.9(n)-2.9(c)-32.4(t)-1.6(e)-6(r c)2.9(o)-4(nv)-2.5(u)-1.6(l)-32.4(s)-12.5(i)-1.4(o)-4(n d)0.8(u)1.6(r)-38.9(i)3.9(n)-0.6(g f)-13.4(o)-3(r e)-32.3(x)-32.6(t)-9.5(r)3.3(a)-5.2(p)-11.3(e)-6(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.4(l r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.8(s)]TJ ET /GS2 gs q 1 0 0 1 70.8661 547.9231 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 292.2185 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 337.5728 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 382.9272 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 547.9231 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 473.6358 547.9231 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 527.1039 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 526.8539 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 292.2185 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 428.2815 526.8539 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 473.6358 526.8539 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 515.6346 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 515.3846 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 503.9234 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 515.3846 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 515.3846 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 504.1734 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 492.7121 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 503.9234 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 246.8642 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 503.9234 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 503.9234 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 492.7121 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 492.4621 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 481.0008 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 492.4621 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 492.4621 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 481.2508 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 469.7895 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 481.0008 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 246.8642 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 428.2815 481.0008 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 473.6358 481.0008 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 469.7895 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 469.5395 cm 0 0 m 175.998 0 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1 428.2815 458.0782 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 473.6358 458.0782 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 446.8669 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 446.8669 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 446.6169 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 246.8642 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 246.8642 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 446.6169 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 473.6358 446.6169 cm 0 0 m 51.274 0 l S Q q 1 0 0 1 473.6358 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 435.4057 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 435.1557 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 292.2185 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 337.5728 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 382.9272 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 428.2815 435.1557 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 473.6358 435.1557 cm 0 0 m 51.274 0 l S Q BT /GS1 gs /T1_1 1 Tf 8 0 0 8 83.599 539.2885 Tm (\026\013\212\002\f\b\r\b\t\r \240\t\210\f\001\217\t\t \217\226\t\b\220\003\ \r\006\004 \212\006\235\214\002\005 )Tj 7.985 -1.2 Td (\220\t\230\220\t)Tj 13.278 0.6 Td (\255\t\214\002\f\013)Tj 5.46 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj 6.988 0 Td (\026\217\r\n\002)Tj -51.925 -2.034 Td (\017\206\233\r\214\013 \013\206\002\006\002\220)Tj /T1_4 1 Tf 24.136 0.001 Td (N)Tj /T1_1 1 Tf 5.426 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj 5.746 0 Td (75)Tj /T1_0 1 Tf -52.594 -1.433 Td (\212\026, \r\t\023\024\035\027\016\033)Tj /T1_2 1 Tf 24.199 0 Td (n)Tj /T1_0 1 Tf 5.419 0 Td (16)Tj 5.919 0 Td (8)Tj 5.419 0 Td (16)Tj 5.919 0 Td 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VeE2Rd+c  uRnU;l-Uו I%ZC܏&YIM95(Efcn\T۳F"! Tel{_T T4:rL'\Mi=d, lyKmy RsNOļռkFUM)dxdŴhI|"$E)9ȉ`x8\:Ɠ:Sf;G1NXD';ݮY=iN҈he%h7@׵@t.$ +EHl[)y0QuwkUt&-fbۇ\J&c6Y2󧴁|/:{H"%H%2ᛅ1ɍ$V-bzOHQMC'kBcge9-yվBɗ= [,yAR%Y[(hi=lZI)fusꊧ$$zJ&̫qn*b\J3cy|/:{HY2󧴂"]i'qHgo][,y@վBɗ=Ou Ze2nF$г}BS֜ǍlOPORIA/ɮ-uo96QWK|/:{HY2󧴂"7u*MLR3=}!dΞL UQ֙v̮!@iRTI"T̺X I|/:{HY2󧴂%U\qp]jP>9;(%վBɗ= [,yAUHdY-ȷuMj]&# R]igD:\5&(oeOiV &^txfQIZ.O$Ibٍ#p-I3g9Eh_":enkuȞi'!dΞ T23uס f4%xM9'yTJ2^b(m:ui4-$ſ|/:{HY2󧴂i*5~=6aCӅ\K:zJO0* Vd*y|ִOnZ7z[,yAՔPk)9VS1&۞؃Ԍ(Hq/&>* pqQoľM5o׸Vgl[9-վBɗ= [,yAESff˳De UJ.t@Y2󧴁|/:{H8TȉrThԤXc"1е@ڕ7"]MߎLsz919]i{LX15PuG'GHЕ9֤q)#%Vf6LC)j͆Xr2"%jKm5ZI*)JQRDX9I2R%ʐ댼˓WJ4-1Xc14++nP7J]i!o $ȎQֆb py֘iodIj j$=co%j;fVjXIQn Ȓi07[^(ufF*TF=<=4څ7>=iO Lcx۪)R%fy2eG5bESp0Ʀ%lݕ#ARhёUTC$3W%(fU#TRdE⟅BL֓IM03Ze5(*AMi&Dg1эp L *!MgZ9m["{C$1R`"O:&F^NSAҵ@ӵ@ endstream endobj 952 0 obj <>stream endstream endobj 948 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.258 Tw 10 0 0 10 42.5197 493.4479 Tm (\026\002\212\006\002\217 \2367:)Tj /T1_2 1 Tf ( \253\211\022\026\032\017\021\036 \023\024\f\035\036\007\024\r\026\021\036\ \035\034\027\024\f\021\034 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.107 Tw 0 -1.218 TD [(\027\036\027\017\016 )0.6(\220\021\026\023\024\r )0.5(\024\023\036\030\026\021\017\r\027\024\020\024 )0.5(\r\n\036\001\026\021\036\035\034\f\021\r\026 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.306 0 Td (\r\027\036)Tj 0 Tw (-)Tj 0.065 Tw -20.306 -1.218 Td (\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\ \016\n\024\005 \022\017\001\022\017: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \235\024\030\n\017\030\031\033 )Tj -0.004 Tw T* (\022\024\035\024\f\021\024\n\031; 2)Tj /Span<>> BDC ( )Tj EMC (\227 \031\001\017\r\026\033 \035\026\023\026\030\024\021\024\n\027\031\033\ \030\026\027\031; 3)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021)Tj 0 Tw (-)Tj 0.112 Tw T* (\n\t\r\026\033 \007\017\f\021\026\035\034\027\031\033 \004\026\f\021\034\ \022\017\001\022\017; 4)Tj /Span<>> BDC ( )Tj EMC (\227 \007\030\036\027\017\030\031\033 \023\026)Tj 0 Tw (-)Tj 0.052 Tw T* (\030\026\030\036\022\021\026\035\034\027\031\033 \022\035\036\021\004\026\ \021\022\031; 0)Tj /Span<>> BDC ( )Tj EMC (\227 \027\036 \007\030\036\027\017\030\031\033 \023\026\030\026\030\036\022\ )Tj 0 Tw (-)Tj T* (\021\026\035\034\027\031\033 \022\035\036\021\004\026\021\022\031\273.)Tj 0.574 Tw T* (\222\030\026\r\027\036\027\017\036 \022\024\n\002\017\027\026\006\017\005\ \023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017 \007\ \030\036)Tj 0 Tw (-)Tj 0.473 Tw T* (\027\017\030\024\r\026\027\017\016 \023\026\030\026\030\036\022\021\026\035\ \034\027\024\005 \022\035\036\021\004\026\021\022\017 \f\021\026\021\017\ \f\021\017\004\036)Tj 0 Tw (-)Tj 0.254 Tw T* (\f\022\017 \027\026\004\017\n\024 \027\036 \030\026\035\017\004\026\035\ \f\016 \n\036\032\007\031 \211\204\215 \(\022\030\017\021\036\030\017\005\ )Tj 0 Tw T* (\205\017\001\036\030\026\226\205\030\017\n\026\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_3 1 Tf 11.821 0 Td (\032)Tj /T1_2 1 Tf 0.066 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,95\), )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\027\031\021)Tj 0 Tw (-)Tj 0.466 Tw -11.821 -1.218 Td [(\030\036\027\027\016\016 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\b\026\030\026\022\021\036\030\017\024\r\026\035\026\f\034 )0.6(\f\035\026\002\024\005 )]TJ 0.072 Tw 23.244 13.396 Td (\f\017\035\024\005 \f\r\016\017 \(\022\024\220\235\235\017\006\017\036\027\ \021 \f\024\023\030\016\032\036\027\027\024\f\021\017 \025\030\026\n\036\ \030\026, )Tj /T1_3 1 Tf 0 Tw T* (V)Tj /T1_2 1 Tf -0.022 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,33 \(0,11; 0,52\))Tj /Span<>> BDC ( )Tj EMC 8.053 0 Td (%. \203\026\017\002\024\035\036\036 \004\026\f\021\t\n\017 \022\024\n\002\ \017\027\026\006\017)Tj 0 Tw (-)Tj 0.076 Tw -8.053 -1.218 Td [(\016\n\017 )0.5(\016\r\035\016\035\017\f\034 )0.5(\2531-2-3-4\273 )0.6(\023\030\017\n\036\027\016\036\n\026\016 )0.5(25/75 )0.5(\030\036\f\023\024\027)]TJ 0 Tw (-)Tj 0.225 Tw T* (\007\036\027\021\026\n\017)Tj /Span<>> BDC ( )Tj EMC (\227 33 \(22; 45\))Tj /Span<>> BDC ( )Tj EMC 10.414 0 Td (% \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\002\017\027\026\006\017\016 \2531-2-4-3\273 )Tj 0.381 Tw -10.414 -1.218 Td (\017\f\023\024\035\034\031\036\n\026\016 16/75 \b\017\030\031\030\020\026\ \n\017)Tj /Span<>> BDC ( )Tj EMC (\227 21 \(13; 32\))Tj /Span<>> BDC ( )Tj EMC 21.351 0 Td (% )Tj 0 Tw -21.351 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj 0.394 Tw T* (\222\024\r\024\022\031\023\027\024\f\021\034 \r\026\030\017\026\027\021\024\ \r \023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\036\005\ \r\t)Tj 0 Tw (-)Tj 0.268 Tw T* [(\023\024\035\027\036\027\017\016 )0.6(\007\030\036\027\017\030\024\r\026\027\017\016 )0.5(\023\026\030\026\030\036\022\021\026\035\034\027\024\005 )0.6(\022\035\036\021\004\026\021\022\017 )]TJ 0.251 Tw T* (\030\026\007\036\035\017\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \022\035\033\004\036\r\t\036 \020\030\031\023\023\t: 1 \020\030\ \031\023\023\026 \023\024)Tj 0 Tw (-)Tj 0.132 Tw T* (\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\036\005, \020\007\ \036 \007\030\036\027\017\030\024\r\026\027\017\036 \023\030\036\007\001\ \036\f\021\r\031\036\021 )Tj 0.065 Tw T* (\031\001\017\r\026\027\017\033 \035\026\023\026\030\024\021\024\n\027\024\ \005 \030\026\027\t,)Tj /Span<>> BDC ( )Tj EMC (\227 49/68 \030\036\f\023\024\027\007\036\027)Tj 0 Tw (-)Tj 0.013 Tw T* [(\021\024\r )0.6(\017\035\017 )0.5(73 )0.6(\(61; )0.6(83\))]TJ /Span<>> BDC ( )Tj EMC 8.023 0 Td [(% )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 1.768 0 Td [(2 )0.6(\020\030\031\023\023\026, )0.6(\020\007\036 )0.5(\026\022\030\t\021\017\036 )0.6(\002\030\033\001)]TJ 0 Tw (-)Tj 0.131 Tw -9.791 -1.218 Td (\027\024\005 \023\024\035\024\f\021\017 \023\030\036\007\001\036\f\021\r\ \031\036\021 \007\030\036\027\017\030\024\r\026\027\017\033,)Tj /Span<>> BDC ( )Tj EMC (\227 19/68 )Tj 0.128 Tw T* (\017\035\017 27 \(17; 39\))Tj /Span<>> BDC ( )Tj EMC 6.771 0 Td (% \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (9\). \221\026\022\017\n \024\002\030\026\024\n, \022\024\n\002\017)Tj 0 Tw (-)Tj 0.017 Tw -6.771 -1.218 Td (\027\026\006\017\017 \023\024\f\035\036\007\024\r\026\021\036\035\034\027\ \024\f\021\036\005 \031\001\017\r\026\027\017\016 \035\026\023\026\030\024\ \021\024\n\027\024\005 )Tj 0.087 Tw T* (\030\026\027\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\n \023\036\030\017\027\036\026\035\ \034\027\t\n \007\030\036\027\017\030\024\r\026\027\017\036\n )Tj 0 Tw T* (\023\030\017\n\036\027\016\035\017\f\034 \004\026\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (2,7 \(1,6; 4,6\) \030\026.)Tj /T1_1 1 Tf 0.124 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2368: )Tj /T1_2 1 Tf (\253\025\026\022\026\016 \024\f\027\024\r\027\026\016 \006\036\035\034 \r\ \t\023\024\035\027\036\027\017\016 \030\031)Tj 0 Tw (-)Tj -0.013 Tw 0 -1.218 TD (\021\017\027\027\024\020\024 \023\026\030\026\030\036\022\021\026\035\034\ \027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033)Tj 0 Tw (-)Tj T* (\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\016\n\024\005\ \022\017\001\022\017?\273)Tj 0.326 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \006\036\035\017 )Tj -0.013 Tw T* (\007\030\036\027\017\030\024\r\026\027\017\016 \f\030\036\007\017 \030\036\ \f\023\024\027\007\036\027\021\024\r \017\f\f\035\036\007\031\036\n\t\b \ \211\204\215 )Tj 0.227 Tw T* (\027\036 \r\t\016\r\035\036\027\024 \(\022\030\017\021\036\030\017\005 \205\ \017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\024\ \027\026, )Tj /T1_3 1 Tf 0 Tw T* (\032)Tj /T1_2 1 Tf 0.22 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,23\), \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \r\027\031\021\030\036\027\027\016\016 \020\036\021\036\030\ \024\020\036\027\027\024\f\021\034 \b\026)Tj 0 Tw (-)Tj 0.382 Tw T* (\030\026\022\021\036\030\017\024\r\026\035\026\f\034 \f\035\026\002\024\ \005 \f\017\035\024\005 \f\r\016\017 \(\022\024\220\235\235\017\006\017\ )Tj 0 Tw (-)Tj 0.091 Tw T* (\036\027\021 \f\024\023\030\016\032\036\027\027\024\f\021\017 \025\030\026\ \n\036\030\026, )Tj /T1_3 1 Tf 0 Tw (V)Tj /T1_2 1 Tf 0.091 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,23 \(\2440,002; 0,43\). )Tj 0.216 Tw T* (\207\024\035\034\001\017\027\f\021\r\024 \024\023\030\024\001\036\027\027\ \t\b \f\023\036\006\017\026\035\017\f\021\024\r 53/75 \017\035\017 )Tj 0.147 Tw T* (70 \(59; 81\) % \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \211\204\215 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \030\031\021\017\027)Tj 0 Tw (-)Tj 0.167 Tw T* (\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \023\030\ \036\f\035\036\007\031\033\021 \006\036\035\034 \023\030\024\235\017\035\ \026\022\021\017\022\017 )Tj 0.349 Tw T* [(\017\027\235\036\022\006\017\024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\024\030\024\027\t \022\ \035\036\021\004\026\021\022\017 )]TJ 0.19 Tw T* (\021\026\026. \210\007\027\026\022\024 11/75 \017\035\017 15 \(7; 25\))Tj /Span<>> BDC ( )Tj EMC 15.183 0 Td (% \030\036\f\023\024\027\007\036\027\021\024\r )Tj -0.046 Tw -15.183 -1.218 Td (\030\026\f\f\004\017\021\t\r\026\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\036\r\030\036\n\036\027\027\031\033 \007\017\026\020\027\024\f\021\ \017\022\031 \017\027\235\036\022)Tj 0 Tw (-)Tj 0.074 Tw T* [(\006\017\024\027\027\t\b )0.6(\024\f\035\024\032\027\036\027\017\005 )0.5(\f\024 )0.5(\f\021\024\030\024\027\t )0.6(\022\035\036\021\004\026\021\024\004\027\t\b )0.6(\023\030\024)]TJ 0 Tw (-)Tj -0.038 Tw T* (\f\021\030\026\027\f\021\r \021\026\026 \023\031\021\036\n \030\031\021\ \017\027\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016,\ \026)Tj /Span<>> BDC ( )Tj EMC (10/75 )Tj ET q 42.52 218.239 221.102 126.508 re W n q /GS0 gs 221.1023475 0 0 126.5156782 42.5196833 218.2307037 cm /Im0 Do Q Q BT /T1_3 1 Tf 0.119 Tw 8 0 0 8 42.5197 208.6394 Tm (\004\032\022\026\027\007\020\025\022\027: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \253\016\020\024\027\007\n\022\273 \025\020)Tj /Span<>> BDC ( )Tj EMC (\030\032\027\025\020\255\020\200, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \r\032\031\021\027\025\017 \030\027\203\027\n\023\020 )Tj 0.072 Tw 0 -1.2 TD (\n\022\213\n\022, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \025\020)Tj /Span<>> BDC ( )Tj EMC (2 \024\026 \b\f\r\240\255\027 \030\027\203\027\n\023\020 \n\022\213\n\022\ , 4)Tj /Span<>> BDC ( )Tj EMC (\227 \021\013\024\031\023\020 \033\020\f\017\006\020, )Tj -0.036 Tw T* (5)Tj /Span<>> BDC ( )Tj EMC (\227 2\2314)Tj /Span<>> BDC ( )Tj EMC (\024\026 \b\f\r\240\255\027 \023\020\016\031\021\031\235 \030\022\020\203\ \032\020\b\026\013, 6)Tj /Span<>> BDC ( )Tj EMC (\227 \n)Tj /Span<>> BDC ( )Tj EMC (\023\020\016\031\021\031\235 \030\022\020\203\032\020\b\026\027, )Tj 0.017 Tw T* (\f\027\021\020\023\031\032\020\026, 7)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031)Tj /Span<>> BDC ( )Tj EMC (\023\020\016\031\021\031\235 \240\032\005\213\022\025\013, 8)Tj /Span<>> BDC ( )Tj EMC (\227 \016\020)Tj /Span<>> BDC ( )Tj EMC (\024\027\030\020\f\022\212\025\013\027 \240\r\b\032\013, )Tj 0.14 Tw T* (9)Tj /Span<>> BDC ( )Tj EMC 0.873 0 Td [(\227 )0.5(\031\032\022\027\025\023\022\032\r\005\024\017 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 9.111 0 Td [(\032\027\016\r\f\017\023\020\023\013 )0.6(\n\031\026\033\017\005\023\027\032\025\031\235 )0.5(\023\031\026\031\b\032\020\203\022\022, )]TJ 0 Tw -9.984 -1.2 Td (10)Tj /Span<>> BDC ( )Tj EMC (\227 \016\020\023\032\r\030\025\t\005\024\017 \031\023\021\027\023\022\023\ \017, 11)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027 \030\032\027\025\022\032\r\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.235 Tw 9 0 0 9 42.5197 144.1701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\022\020\b\032\020\026\026\020 \032\020\024\033\032\027\030\027\f\027\ \025\022\t \030\031\f\027\235 \021\013\240\031\032\020 \032\027)Tj 0 Tw (-)Tj -0.029 Tw T* (\024\033\031\025\030\027\025\023\020\026\022 \031\032\022\027\025\023\022\ \032\020 \030\f\t \n\031\025\023\032\031\f\t \b\f\r\240\022\025\013 \r\024\ \023\020\025\031\021\n\022 )Tj 0 Tw T* (\033\020\032\020\032\027\n\023\020\f\017\025\013\200 \030\032\027\025\020\ \255\027\235 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.036 Tw T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( Diag)14(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the distr)-36.9(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(ropor)-40(tions of)]TJ /Span<>> BDC ( )Tj EMC (re)Tj 0 Tw (-)Tj -0.004 Tw T* [(spondents)33(\222 )0.5(choice of)]TJ /Span<>> BDC ( )Tj EMC 8.084 0 Td (a)Tj /Span<>> BDC ( )Tj EMC [(reference )0.5(point )0.5(for monitor)-36.9(ing the)]TJ /Span<>> BDC ( )Tj EMC [(dep)13(th )]TJ 0.21 Tw -8.084 -1.2 Td (of)Tj /Span<>> BDC ( )Tj EMC (installation of)Tj /Span<>> BDC ( )Tj EMC [(pararectal drains in e)-15(xtraper)-37(itoneal rectal )]TJ 0 Tw T* [(w)12(ounds)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.123 Tw 0 72.346 TD [(\020\004\206\f\t\204\004 )0.5(8.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( )0.5(\216\f\r\240\022\025\020 )0.5(\r\024\023\020\025\031\021\n\022 )0.5(\033\020\032\020\032\027\n\023\020\f\017\025\013\200 )0.5(\030\032\027\025\020\255\027\235 )0.6(\032\027\024\033\031\025\030\027\025\023\020\026\022 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC 33.965 0 Td [(\211\240\206\004\202 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 4.367 0 Td [(\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 )0.5(\031\n\020\016\020\025\022\t )]TJ 0 Tw -38.332 -1.2 Td (\026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf -0.027 Tc 0.163 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(8)-39.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.136 Tw 3.474 0 Td [( )0.5(T)-6.4(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC 2.116 0 Td [(d)-5.3(e)-7.7(p)-2.5(t)-10.6(h )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 3.794 0 Td [(i)3.9(n)3.7(s)-14.8(t)-2(a)-4.5(l)-3.8(l)-1.1(a)-9.2(t)-29.1(i)-1.4(o)-4(n )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 6.098 0 Td [(p)-6.3(a)-4.2(r)3.3(a)-4.2(r)-1.9(e)-10.9(c)-32.4(t)-2(a)-4.5(l )0.5(d)0.8(r)3.3(a)-6.3(i)3.9(na)-5.2(g)-6.7(e )0.5(b)-2.4(y )0.5(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(n)-0.6(t)-32.9(s )0.6(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 15.823 0 Td [(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.2(e)-6(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l )0.5(r)-2(e)-10.9(c)-32.4(t)-1.9(a)-4.5(l )0.5(w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.8(s )0.5(a)-9.2(t )0.5(v)6.3(a)-4.1(r)-39(i)-1.4(o)-3.4(u)-4.4(s )0.5(le)-8.2(v)2.3(e)-6.1(l)-32.4(s )]TJ -0.003 Tc 0.003 Tw -31.306 -1.2 Td [(o)1(f)]TJ /Span<>> BDC 0.792 0 Td ( )Tj EMC [(m)-8.3(e)-15.9(d)-6(i)-4.8(ca)-7.5(l)-2.9( ca)-7.2(r)-5(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.5809 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 207.1791 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 255.3681 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 693.5809 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 693.5809 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 682.3617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 682.1117 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 207.1791 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 255.3681 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 303.5571 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.935 682.1117 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 448.124 682.1117 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 670.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 670.6425 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 659.1812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 670.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 670.6425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.4312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 647.9699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 659.1812 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 659.1812 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 659.1812 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 659.1812 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 659.1812 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 659.1812 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 647.9699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 647.7199 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 636.2587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 647.7199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 647.7199 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 636.5087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 625.0474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 636.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 636.2587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 636.2587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 636.2587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 636.2587 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 636.2587 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 625.0474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 624.7974 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 613.3361 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 624.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 624.7974 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 613.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 602.1248 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 613.3361 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 613.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 613.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 613.3361 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 613.3361 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 613.3361 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 602.1248 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 601.8748 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 590.4135 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 601.8748 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 601.8748 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 590.6635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 579.2022 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 590.4135 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 158.9902 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 590.4135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 590.4135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 303.5571 590.4135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 590.4135 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 351.7461 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 399.935 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 447.874 590.4135 cm 0 0 m 48.689 0 l S Q q 1 0 0 1 448.124 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 579.2022 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 578.9522 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 158.9902 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 255.3681 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 578.9522 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 448.124 578.9522 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 567.741 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 567.491 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 158.9902 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 158.9902 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 207.1791 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 255.3681 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 567.491 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 448.124 567.491 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 546.6797 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 546.4297 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 158.9902 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 207.1791 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 255.3681 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 303.5571 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 351.7461 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 399.935 546.4297 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 448.124 546.4297 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 8 0 0 8 49.4486 684.9464 Tm (\027\f\210\206\t\b\004 \210\217\003\004\b\002\220\t \240\006\r\b\004\202\ \r\005)Tj 14.725 0 Td (\255\t\214\002\f\013)Tj 5.814 0 Td (2 \210\006\002\r\b\001)Tj 6.024 0 Td (3 \210\006\002\r\b\001)Tj 6.024 0 Td (4 \210\006\002\r\b\001)Tj 6.024 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 7.953 0.001 Td (\t)Tj /T1_1 1 Tf 5.058 -0.001 Td (\026\217\r\n\002)Tj /T1_2 1 Tf -52.102 -1.433 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 16.873 0 Td (N)Tj /T1_1 1 Tf 5.78 -0.001 Td (17)Tj 6.024 0 Td (12)Tj 6.024 0 Td (14)Tj 6.302 0 Td (5)Tj 11.769 0 Td (48)Tj /T1_2 1 Tf -52.771 -1.433 Td (\212\024 7 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (5)Tj 6.024 0 Td (1)Tj 6.024 0 Td (1)Tj 6.024 0 Td (1)Tj 5.181 0 Td (0,64*)Tj 6.866 0 Td (8)Tj /T1_3 1 Tf -36.915 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 5.039 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(9; 60\))Tj 6.274 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(0; 44\))Tj 6.14 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(0;39\))Tj 5.657 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(0; 76\))Tj 12.047 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(7; 30\))Tj -51.318 -1.433 Td (8\22610 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (7)Tj 6.024 0 Td (4)Tj 6.024 0 Td (7)Tj 6.024 0 Td (3)Tj 5.181 0 Td (0,96*)Tj 6.616 0 Td (21)Tj /T1_3 1 Tf -36.665 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 4.789 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(16; 71\))Tj 6.274 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(8; 69\))Tj 5.89 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(20;80\))Tj 5.907 0 Td (60)Tj /Span<>> BDC ( )Tj EMC (\(11; 96\))Tj 12.047 0 Td (44)Tj /Span<>> BDC ( )Tj EMC (\(29; 59\))Tj -51.068 -1.433 Td (11\22615 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (5)Tj 6.024 0 Td (5)Tj 6.024 0 Td (5)Tj 6.024 0 Td (1)Tj 5.181 0 Td (0,94*)Tj 6.616 0 Td (16)Tj /T1_3 1 Tf -36.665 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 5.039 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(9; 60\))Tj 5.89 0 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(13;76\))Tj 6.024 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(11;71\))Tj 6.274 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(0;76\))Tj 11.681 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(20; 48\))Tj -51.068 -1.433 Td (\207\024\035\036\036 15 \f\n)Tj /T1_3 1 Tf 16.935 0 Td (n)Tj /T1_2 1 Tf 6.024 0 Td (0)Tj 6.024 0 Td (2)Tj 6.024 0 Td (1)Tj 6.024 0 Td (0)Tj 5.181 0 Td (0,63*)Tj 6.866 0 Td (3)Tj /T1_3 1 Tf -36.915 -1.433 Td (f )Tj /T1_2 1 Tf (\(%\))Tj 5.289 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.774 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(2; 56\))Tj 6.274 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(0; 39\))Tj 6.024 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 58\))Tj 12.047 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(1; 17\))Tj /T1_3 1 Tf -51.568 -1.433 Td (p)Tj /T1_2 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_3 1 Tf 16.946 0 Td (p)Tj /T1_2 1 Tf 14.456 0 Td (0,63)Tj -31.402 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_3 1 Tf (V)Tj /T1_2 1 Tf ( )Tj 0 -1.2 TD (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_3 1 Tf 16.946 1.2 Td (V)Tj /T1_2 1 Tf 11.837 0 Td (0,23)Tj /Span<>> BDC ( )Tj EMC (\(-0,02; 0,48\))Tj /T1_3 1 Tf 7 0 0 7 42.52 534.945 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ 0 -1.2 TD (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.5021 56.0378 Tm (109)Tj ET endstream endobj 949 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;:   Y!13s4ASq"7QRTUa#$26BCbt %&'()*589:DEFGHIJVWXYZcdefghijruvwxyz?DAAAAAAAAAAAAAADAAYr|{rl<ѯv:3AG}"k).DגS]5MFbERh;:J{5G}"k).G5FbEReJi).DגS]$8L%"E4^IOtqw&My%=H<2LfEJkμMy%=HJ{NyEFd,'B;? gli 39mi 4-*X @h\uNBDU 4Wg ]PHqu_Wze&.Hu_V Rb =(j摎JXZADABt͙r1Z.NC6 * 68n&FgbɈ>\b\TdAE!Hh2JI: 4Ž fJv^"TBȉ 3I"ACRDm8dIQUQ6|15ቬ,诟 y=EA2=΂ΊttWφ&|1J!!ՊdѠ `ȫ z.΂ΊttWφ&|0v )EAh|0gAgE|bk: :+YY_><4FVt؝F|15ቬ,诟  ߉#h:*'z,诟 MgAgE|bk: :+QKEYk: :+YY_>΂Ί` ʌ+sd{ЍgAgE|bk: :+YY_>< QEntbz,诟 MgAgE|cITdž  P3hOk<΂ΊttWφ8\P"+|1႓ʍM5i<΂ΊttWφ8\R"+|1ၓʍM5i<΂ΊttWφ/@7"ƭ )0' zRլDAA_s], XH $jڭP&?#mQIJ<2xP2xPi*Kq*c5+ji4Rm;ye Z*e ZZcmJuklӐ*#'ʁ&cNiI$ATg,2xP2xPґcqŶiRDG{=)`yj G JVJȔGd[l6kYBLgY$EdHXXJ" >љ-%&\zJlI2Iġ<îÚU+Ԛ;M"5xum&2Ԩw**L&Dduʐ:Ma6):)5(Ft晏Rf+ X,7yf64^4Dd%X v NQKc:r (N9VNv^1Q8fnӷRtfP5"*r 4.X!" e몂DЫj @h Ja$A¸@dL A|a]c#H A'oSO`&'t$ہ NQsHi,-Z @$&.=JUY&dU Tt4RI.>lTH+qpa08YP+Xae ^_ɱ0<N5Tk[)qFUU-PVLR <$h6er;Mft:=ӇR34 jy#)DGs], XH >E'ȾBd<6,;[yd<L"qt"AF:HA'[Qy/>>E.:\L2y27gdg()FGD&$\FKURJ"H"m3٢JREX".F,JJJ:h;X rT#m+T#m+T^!G1ntMd66X!xFЯJJ;)NK~XNam***HI)FEmg狽B6Ҽ%B6Ҽ-0 d֕4mtrșDl*|(CPd%U5:mxJmxzvo%Y4N"V6SIr̮(g1k$N5 ćSRёwLFWFWFWeUg+PEB6Ҽ%B6Ҽ%B6Ҽ*V9Z**TV6d+'[QFWFW B*=WVii5UFIGe%=»dž)1rF@N;,0LOI!=(j摎JXZADA?&[;DjV4W]Djjs'U ɖ҅DVJISAdi^Zr:L&.5&IQITנ"'g)A M]%WfS@ 2:X;po a" .\XH[+m.P,I2A$ߑ$w'r 2pffM3M&i*(*@ OsRDT{H'"Y4UjFuG"!P%y\~Uvq'"*,Ң !v:[y ZxAG樂/)z' @Zv{ A" iU5+I*t;qn1ԒL\ʒ:, %rlS^Q(vV9XJq1&)X]Wަ<0I4vؕ9d bBM=tGW4vzRլDAe)6V88Ԛ5fDf'IW##<'ʢI;N4-FTd4L D@5&jZvT&iNqkbŀA⊊b ȸT4 kU1M5ndP09ĔZ骬uȓE2!ð+ 2U-$< >'./}5xAM?8\Z乽 Ue$fgfHzYh'Ś}imۉԣ2iZ\DmwoCSrp-AlDi=6d5Kө!r^H {E*g0 ʒyĚ]gb#*N͚׹/_NLzu"d5KөS)eIٮ{ \zu"d5Kө!r^Hb{pP󈩗bKa4עJN5Kө!r^H" dSQNN@J<(-^zb׹/_NLzu#a/Z՚RĶNMř<8dh[Ԙ5Kө!r^HD,<S>R+8Cɛ}q,Edh+jzu"d5KөV4CD3G>R=&&rg@q݅&8ڶ1hkܗR&C^}:%$%M؅ 4PTYIx&đ:=Ȅ<$TTsiX%ԉ׹/_N^Z$XCà4n zRլDAF5]E$u+"Ri*t#T sDk 6FFHu q4m #!eaKKM6U(BfC9ݮx}-2GK. ,$A2nlÜ(sAF||=՟/" n)6nH͔xL[]$Tʜݠ$TRIQ-'^- Pl-%H(NBoII6Zo(""4[5 JiQGȷ蔪$Zާ)x WGa#+s^~%v](zF*q˄b Қ7x́w B 0 :A]8zQG#'./}5xAM?8\:Dr6Sxd뙙""f(9%G%DLT{֫BPv) $Ag&RsrjJkJ2:K8$IMDax$,׍LgA&آtˆ{MQ+t{˃xK AL0=\v,,0  %IIU3;HYnWKSjAQ(Sr7>RYq-Ғ5Rh 'ӺDf:R['Im!JR\fyLf8B9 '6*NԑЕ(Rgm6ac%&QRM$gSACdI";4#b  #4!h:)4fdtҒy :$%F"Z3$'J{}9(zF*q˄b Ʊi)j1dT1!PuQ\:&vJeFTԒ(:3@:+@dž)1rN@NQsHi,-Z DAVNxIKЍɯDSKr-N ߋzJbXr) QmCCt a$vx)8*k/L2i5R=85唷GiTQ!Etl)3I5 /:8ACYiiw*H!ET%JNu唷G,8x_%O.6Q>yu唷G,8Ue=y6Kq45d(XS!$P8U(lL+&Xm,Ey3^YKtq[G~RmWHVJaBI?8yu唷G,8tz^F7 E:iY!IdP8&˩R%DddDVjw[DזRgrT{rl| s 񶴺UAJ"2bJ4gEY%J2JRE32"OTL4umTF(=S$NHn:> g8lmfi @)bSD崷Tt֧EIYVh&J񦲌$T2U6H7=|-CȰy-u,ðR*K3zfvT~*LJh5 W":H{e8"A@9j3&u4mqŦ KŴpNd7 4)RRԢ:+R=2rFGi,..&1jJV"5ң$1̍,+cKxىvmtfFF###Aꥉy\D< FPԥU*VR)"*Jɏ4+3+2y w(YIIc## kKi5)IGXU%Ή.X# BL͢nx-8G'?SHjȪʓ*pfI#R"O'Ω*Tbd826kQ_0vD+JL}P!A(RGMs*+X{qADAAiS.Ҥr2:F+m;eJP3'%$I"*sYDe*OzPTIa5k3*lX"-_n[Q/J104$mŲ5)u*:V (R{m-Z4I"5&Ɋ䘸4.J9Up..)嬢)JA%'Taqz즉-MIPD:&q 5jASEEvd;Q9%Fl q'YU+VĪLR/"C<%9'2i/ Qlԥ5SdosM咤o|U**IW"=*ѕ*F8f9XIrQ-IM4Tv)c,ɰJ{ 2"Q<<[XHEAֱH=TW%H[ɥB2m}D;5L 4nSQ{!Zw- X ^Z`u(p6j#:硚9JbXXUT#q)R#bq%WVPETZ NF)@ƦRL(%/6ΠÍIڪ De}e8e#4hmKIW*RdUuq:ښq$-&$c!VANr)n& BEN>stream endstream endobj 945 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.272 Tw 10 0 0 10 70.8661 493.4479 Tm (\200\t\002\024\030 \030\036\f\023\024\027\007\036\027\021\026\n\017 \024\ \030\017\036\027\021\017\030\024\r \007\035\016 \007\030\036\027\017\030\ \024\r\026)Tj 0 Tw (-)Tj 0.128 Tw 0 -1.218 TD (\027\017\016 \022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\ \021\030\026\027\f\021\r \021\026\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\031\036\n\t\b )Tj -0.012 Tw T* (\211\204\215 \f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\024 \027\036 \030\026\035\017\004\026\035\f\016 \(\022\030\017\021\ \036\030\017\005 )Tj 0 Tw T* (\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_1 1 Tf 11.982 0 Td (\032)Tj /T1_0 1 Tf 0.222 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,27\), \024\007\027\026\022\024 \r\027\031\021)Tj 0 Tw (-)Tj 0.24 Tw -11.982 -1.218 Td [(\030\036\027\027\016\016 )0.6(\020\036\021\036\030\024\020\036\027\027\024\f\021\034 )0.6(\r\t\002\024\030\022\017 )0.5(\b\026\030\026\022\021\036\030\017\024\r\026\035\026\f\034 )]TJ 0.123 Tw T* (\031\n\036\030\036\027\027\024\005 \f\017\035\024\005 \f\r\016\017 \(\022\ \024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\027\ \024)Tj 0 Tw (-)Tj 0.053 Tw T* (\f\021\017 \025\030\026\n\036\030\026, )Tj /T1_1 1 Tf 0 Tw (V)Tj /T1_0 1 Tf 0.053 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,55 \(0,21; 0,73\)\). \210\f\027\024\r\027\t\n \024\030\017\036\027)Tj 0 Tw (-)Tj 0.109 Tw T* (\021\017\030\024\n \007\035\016 \002\024\035\034\001\017\027\f\021\r\026\ \030\036\f\023\024\027\007\036\027\021\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024)Tj 0 Tw (-)Tj 0.049 Tw T* (\r\026\027\017\017 \022\035\036\021\004\026\021\024\004\027\t\b \023\030\ \024\f\021\030\026\027\f\021\r \021\026\026 \023\036\030\017\027\036\026\ \035\034\027\t\n )Tj 0.04 Tw T* (\007\024\f\021\031\023\024\n \016\r\035\016\035\026\f\034 \035\024\022\026\ \035\017\026\006\017\016 \030\026\027\t \f\021\036\027\022\017 \023\030\ \016\n\024\005 )Tj 0.256 Tw T* (\022\017\001\022\017, \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\005 \031\f\021\026\027\026\r\035\017\r\026\035\017\ \f\034 \007\030\036\027\026\032\017 13/48 )Tj 0.267 Tw T* (\017\035\017 31 \(18; 47\))Tj /Span<>> BDC ( )Tj EMC 7.187 0 Td (% \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\). \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\ \024 )Tj 0.017 Tw -7.187 -1.218 Td (\023\024)Tj /Span<>> BDC ( )Tj EMC (1/48 \030\036\f\023\024\027\007\036\027\021\031 \017\035\017 2 \(0; 13\)\ )Tj /Span<>> BDC ( )Tj EMC 14.346 0 Td (% \023\030\036\007\023\024\004\035\017 \031\f\021\026)Tj 0 Tw (-)Tj -0.014 Tw -14.346 -1.218 Td (\027\024\r\022\031 \007\030\036\027\026\032\036\005 \022)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\005 \002\030\033\001\017\027\036 \017)Tj /Span<>> BDC ( )Tj EMC (\026 \f\036\007\026\035\017\013\027\t\036 )Tj 0.036 Tw 23.244 15.831 Td (\002\031\020\030\t, \026)Tj /Span<>> BDC ( )Tj EMC (6/48 \030\036\f\023\024\027\007\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 14 \(5; 29\))Tj /Span<>> BDC ( )Tj EMC 17.334 0 Td (% \024\030\017\036\027\021\017)Tj 0 Tw (-)Tj -17.334 -1.218 Td (\030\031\033\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\027\031 \023\026\035\034\006\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.018 Tc 0.021 Tw T* (\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b\ \030\026\035\017\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \020\035\031\002\017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.042 Tw T* [(\027\t \007\030\036\027\017\030\024\r\026\027\017\016 \023\026\030\026\030\ \036\022\021\026\035\034\027\024\005 \022\035\036\021\004\026\021\022\017\ \f\030\036\007\017)18( )]TJ 0.017 Tw T* (\030\036\f\023\024\027\007\036\027\021\024\r \017\f\f\035\036\007\031\036\ \n\t\b \211\204\215 \027\036 \r\t\016\r\035\036\027\024 \(\022\030\017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.089 Tw T* (\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\n\036\027\026\ \226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tc 0 Tw (\032)Tj /T1_0 1 Tf 0.018 Tc 0.089 Tw /Span<>> BDC 15.592 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,63\). \222\030\036\007\017)18.1( )]TJ 0.519 Tw -15.592 -1.218 Td [(\r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\r \027\026\017\002\ \024\035\036\036 \023\030\036\007\023\024\004\021\017\021\036\035\034\027\ \024\005)18( )]TJ 0.067 Tw T* (\020\035\031\002\017\027\024\005 \031\f\021\026\027\024\r\022\017 \023\026\ \030\026\030\036\022\021\026\035\034\027\t\b \007\030\036\027\026\032\036\ \005 \016\r)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.033 Tw T* (\035\016\035\026\f\034 8\22610)Tj /Span<>> BDC ( )Tj EMC (\f\n 21/48 \017\035\017 44 \(29; 59\))Tj /Span<>> BDC ( )Tj EMC 16.484 0 Td [(%. \210\021\n\036\004\036\027\024,)18( )]TJ 0.078 Tw -16.484 -1.218 Td (\004\021\024 3/48 \030\036\f\023\024\027\007\036\027\021\026 \017\035\017\ 6 \(1; 17\))Tj /Span<>> BDC ( )Tj EMC 15.709 0 Td (% \024\f\031\013\036\f\021\r\035\016)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.111 Tw -15.709 -1.218 Td (\033\021 \031\f\021\026\027\024\r\022\031 \023\026\030\026\030\036\022\021\ \026\035\034\027\t\b \007\030\036\027\026\032\036\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017)Tj 0 Tc 0 Tw (-)Tj 0.018 Tc 0.035 Tw T* [(\027\031 \002\024\035\036\036 15 \f\n, \021\024\020\007\026 \022\026\022\ 8/48 \b\017\030\031\030\020\024\r \017\035\017 17 \(7;)18.1( )]TJ 0.205 Tw T* (30\))Tj /Span<>> BDC ( )Tj EMC 1.567 0 Td (% \031\f\021\026\027\026\r\035\017\r\026\033\021 \007\030\036\027\026\032\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\020\035\031\002\017\027\031 \007\024)Tj /Span<>> BDC ( )Tj EMC [(7 \f\n)18( )]TJ 0 Tw -1.567 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tc 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \205\033\031\024\031\240\013 \030\022\024\023\020\f\017\025\031\b\031 \031\ \023\026\013\021\020\025\022\t \031\023\n\f\005\007\027\025\025\031\235 \ \007\020\024\023\022 \023)0.5(\031\f\024\023\031\235 \n\022\213\n\022 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.076 Tc 0.076 Tw 0 -1.2 TD [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.25 0 Td [( M)-2(e)-8.6(t)-10.6(h)-2.4(o)-11.9(d)-5.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-3(i)6.7(s)-14.9(t)-1.9(a)-4.5(l w)5.1(a)-7.2(s)5.1(h)1.7(i)3.9(n)-0.6(g o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e d)-3(i)6.6(sc)2.9(o)-4(n)0.8(n)-2.4(e)-10.9(c)-32.4(t)-1.6(e)-12.9(d p)-6.3(a)-4.1(r)-41.9(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e c)2.9(o)-5.3(l)-1.6(o)-4(n i)3.9(n c)3.2(a)-7.1(s)0.5(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.1(p)-11.3(e)-6(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l w)2.2(o)-3.3(u)0.6(n)-4.8(d)-5.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 204.3445 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 249.6988 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 295.0532 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 340.4075 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 385.7618 715.181 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 431.1161 715.181 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 694.3618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 694.1118 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 204.3445 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 249.6988 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 295.0532 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 340.4075 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 385.7618 694.1118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 431.1161 694.1118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 694.1118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 682.8925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 682.6425 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 671.1813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 682.6425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 682.6425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 682.6425 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 671.4313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 652.2313 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 204.0945 671.1813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 249.6988 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 295.0532 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 340.4075 671.1813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 385.7618 671.1813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 431.1161 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 479.0551 671.1813 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 652.2313 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 651.9813 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 640.52 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 651.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 651.9813 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 651.9813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 640.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 621.5699 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 204.0945 640.52 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 249.6988 640.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 295.0532 640.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 340.4075 640.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 385.7618 640.52 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 431.1161 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 479.0551 640.52 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 524.6594 621.5699 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 70.8661 621.3199 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 609.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 621.3199 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 621.3199 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 621.3199 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 610.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 598.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.0945 609.8587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 609.8587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 609.8587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 609.8587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 609.8587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.0551 609.8587 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 598.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 598.3974 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 586.9361 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.3445 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 598.3974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 598.3974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 598.3974 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 587.1861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 575.7249 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 204.0945 586.9361 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 204.3445 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 586.9361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 586.9361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 340.4075 586.9361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 385.7618 586.9361 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 385.7618 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 431.1161 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.0551 586.9361 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 479.3051 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 575.7249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 575.4749 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 204.3445 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 249.6988 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 295.0532 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 575.4749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 575.4749 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 575.4749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 564.2635 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 564.0135 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 71.1161 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 204.3445 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 204.3445 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 249.6988 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 295.0532 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 564.0135 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 564.0135 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 431.1161 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 479.3051 564.0135 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 543.2023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 542.9523 cm 0 0 m 133.478 0 l S Q q 1 0 0 1 204.3445 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 249.6988 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 295.0532 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 340.4075 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 385.7618 542.9523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 431.1161 542.9523 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 479.3051 542.9523 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 82.551 706.5464 Tm (\255\212\002\217\002\206 \240\t\217\003\004\f\001\b\002\n\002 \002\003\214\ \013\004\b\t\235 )Tj 3.657 -1.2 Td (\003\002\f\217\003\002\005 \220\t\230\220\t)Tj 12.422 0.6 Td (\255\t\214\002\f\013)Tj 5.46 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_3 1 Tf 7.776 0.001 Td (\t)Tj /T1_2 1 Tf 4.881 -0.001 Td (\026\217\r\n\002)Tj /T1_0 1 Tf -52.279 -2.033 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_3 1 Tf 18.821 0 Td (N)Tj /T1_2 1 Tf 5.426 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_3 1 Tf 5.846 0.001 Td (\226)Tj /T1_2 1 Tf 5.568 -0.001 Td (75)Tj /T1_0 1 Tf -52.948 -1.433 Td (\232\036\030\036 \026\027\026\035\034\027\t\005 \022\026\027\026\035)Tj /T1_1 1 Tf 18.884 0 Td (n)Tj /T1_0 1 Tf 5.669 0 Td (7)Tj 5.669 0 Td (0)Tj 5.419 0 Td (11)Tj 5.919 0 Td (2)Tj 4.754 0 Td (0,002*)Tj /T1_1 1 Tf -0.636 -1.2 Td (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 443.5219 667.08 Tm (3-2)Tj /Span<>> BDC 8 0 0 8 449.8276 664.416 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj /T1_1 1 Tf -1.555 -1.2 Td (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 441.5219 657.4799 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 447.8276 654.8159 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.269 2.4 Td (20)Tj /T1_1 1 Tf -34.894 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.434 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(11; 55\))Tj 6.169 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.169 0 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(25; 75\))Tj 5.919 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(2; 64\))Tj 11.443 0 Td (26)Tj /Span<>> BDC ( )Tj EMC (\(17; 38\))Tj -51.245 -2.4 Td (\232\036\030\036 \f\021\024\n\031)Tj /T1_1 1 Tf 18.884 0 Td (n)Tj /T1_0 1 Tf 5.419 0 Td (10)Tj 5.669 0 Td (16)Tj 5.919 0 Td (3)Tj 5.669 0 Td (6)Tj 4.025 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\327)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 463.8116 646.0187 Tm (-4)Tj 8 0 0 8 467.7853 643.3547 Tm (*)Tj /T1_1 1 Tf -3.515 -1.2 Td (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 443.7993 636.4187 Tm (4-3)Tj /Span<>> BDC 8 0 0 8 450.105 633.7547 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 465.8328 636.4187 Tm (\2264)Tj /T1_1 1 Tf 8 0 0 8 437.3859 624.1547 Tm (\206)Tj /T1_0 1 Tf 4.664 0 0 4.664 441.5219 626.8187 Tm (4-5)Tj /Span<>> BDC 8 0 0 8 447.8276 624.1547 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,019)Tj 6.269 2.4 Td (35)Tj /T1_1 1 Tf -34.894 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.434 0 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(18; 68\))Tj 5.669 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(51; 95\))Tj 5.919 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(2; 40\))Tj 5.419 0 Td (67)Tj /Span<>> BDC ( )Tj EMC (\(26; 94\))Tj 11.693 0 Td (47)Tj /Span<>> BDC ( )Tj EMC (\(35; 59\))Tj -51.245 -2.4 Td (\232\036\030\036 \f\021\024\n\031 \017)Tj T* (\026\027\026\035\034\027\t\005 \022\026\027\026\035)Tj /T1_1 1 Tf 18.884 1.2 Td (n)Tj /T1_0 1 Tf 5.669 0 Td (1)Tj 5.669 0 Td (3)Tj 5.669 0 Td (2)Tj 5.669 0 Td (0)Tj 5.004 0 Td (0,51*)Tj 6.689 0 Td (6)Tj /T1_1 1 Tf -35.144 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.934 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 25\))Tj 5.169 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(25; 42\))Tj 6.169 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(1; 34\))Tj 5.786 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;43\))Tj 11.576 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(3; 17\))Tj -51.745 -1.433 Td (\203\036 \024\021\n\t\r\026\033)Tj /T1_1 1 Tf 18.884 0 Td (n)Tj /T1_0 1 Tf 5.669 0 Td (6)Tj 5.669 0 Td (1)Tj 5.669 0 Td (6)Tj 5.669 0 Td (1)Tj 5.004 0 Td (0,26*)Tj 6.439 0 Td (14)Tj /T1_1 1 Tf -34.894 -1.433 Td (f )Tj /T1_0 1 Tf (\(%\))Tj 4.684 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(8; 52\))Tj 5.919 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(0; 31\))Tj 5.169 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(10; 56\))Tj 5.919 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(0; 57\))Tj 11.443 0 Td (19)Tj /Span<>> BDC ( )Tj EMC (\(11; 29\))Tj /T1_1 1 Tf -51.245 -1.433 Td (p)Tj /T1_0 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_1 1 Tf 18.895 0 Td (p)Tj /T1_0 1 Tf 12.951 0 Td (1,3\26710)Tj /Span<>> BDC 4.664 0 0 4.664 348.1206 569.5123 Tm (-)Tj EMC (4)Tj 8 0 0 8 73.9508 555.387 Tm (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_1 1 Tf (V)Tj /T1_0 1 Tf ( )Tj T* (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_1 1 Tf 18.894 1.2 Td (V)Tj /T1_0 1 Tf 11.127 0 Td (0,35)Tj /Span<>> BDC ( )Tj EMC (\(0,13; 0,53\))Tj /T1_1 1 Tf 7 0 0 7 70.8661 531.4677 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ T* (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020; \032)Tj 4.081 0 0 4.081 331.8351 525.3987 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 342.1558 523.0677 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj ET q 70.866 169.05 198.762 147.391 re W n q /GS0 gs 198.7624821 0 0 147.3915086 70.8661514 169.0494184 cm /Im0 Do Q Q BT /T1_1 1 Tf 0.003 Tw 8 0 0 8 70.8661 159.4394 Tm (\004\032\022\026\027\007\020\025\022\027: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027\032\027\016 \020\025\020\f\017\025\013\235 \n\020\025\020\f\ , 2)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027\032\027\016 \024\023\031\026\r, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027)Tj 0 Tw (-)Tj T* (\032\027\016 \024\023\031\026\r \022)Tj /Span<>> BDC ( )Tj EMC (\020\025\020\f\017\025\013\235 \n\020\025\020\f, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027 \031\023\026\013\021\020\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw 9 0 0 9 70.8661 133.3701 Tm [(\022\t\217\210\b\002\220 )0.6(2.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\220\022\020\b\032\020\026\026\020 )0.7(\032\020\024\033\032\027\030\027\f\027\025\022\t )0.6(\030\031\f\027\235 )0.6(\033\032\022\026\027\025\t\027\026\013\200 )]TJ 0.04 Tw T* (\032\027\024\033\031\025\030\027\025\023\020\026\022 \024\033\031\024\031\ \240\031\021 \030\022\024\023\020\f\017\025\031\b\031 \031\023\026\013\021\ \020\025\022\t \031\023\n\f\005)Tj 0 Tw (-)Tj T* (\007\027\025\025\031\235 \007\020\024\023\022 \023\031\f\024\023\031\235\ \n\022\213\n\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.336 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Diag)14.1(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the distr)-37(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(ropor)-40(tions )]TJ 0.073 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(methods used by respondents for distal w)13(ashing of)]TJ /Span<>> BDC ( )Tj EMC (the dis)Tj 0 Tw (-)Tj T* [(connected par)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC [(the colon in e)-14.8(xtraper)-36.9(itoneal rectal w)12.1(ounds)]TJ ET q 303.307 169.04 192.371 147.401 re W n q /GS0 gs 192.3715316 0 0 147.460826 303.3071116 168.9801569 cm /Im1 Do Q Q BT /T1_1 1 Tf 0.036 Tw 8 0 0 8 303.3071 159.4394 Tm (\004\032\022\026\027\007\020\025\022\027: 1)Tj /Span<>> BDC ( )Tj EMC (\227 \240\022\f\020\023\027\032\020\f\017\025\031 \033\020\032\020\032\027\ \n\023\020\f\017\025\031, 2)Tj /Span<>> BDC ( )Tj EMC (\227 \033\032\027\024\020\n\032\020\f\017)Tj 0 Tw (-)Tj T* (\025\031, 3)Tj /Span<>> BDC ( )Tj EMC (\227 \007\027\032\027\016 \032\020\025\r, 4)Tj /Span<>> BDC ( )Tj EMC (\227 \025\027 \030\032\027\025\022\032\r\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw 9 0 0 9 303.3071 133.3701 Tm [(\022\t\217\210\b\002\220 )0.6(3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\220\022\020\b\032\020\026\026\020 )0.7(\032\020\024\033\032\027\030\027\f\027\025\022\t )0.6(\030\031\f\027\235 )0.6(\033\032\022\026\027\025\t\027\026\013\200 )]TJ 0.586 Tw T* (\032\027\024\033\031\025\030\027\025\023\020\026\022 \024\033\031\024\031\ \240\031\021 \033\027\032\022\025\027\020\f\017\025\031\b\031 \030\032\027\ \025\022\032\031\021\020\025\022\t )Tj 0 Tw T* (\n\f\027\023\007\020\023\031\007\025\013\200 \033\032\031\024\023\032\020\ \025\024\023\021 \023\020\016\020 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.013 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( Diag)14(ram of)]TJ /Span<>> BDC ( )Tj EMC [(the distr)-37(ibution of)]TJ /Span<>> BDC ( )Tj EMC [(the p)46(ropor)-39.9(tions of)]TJ /Span<>> BDC ( )Tj EMC (the )Tj -0.032 Tw T* (methods of)Tj /Span<>> BDC ( )Tj EMC [(per)-37(ineal drainag)12.1(e of)]TJ /Span<>> BDC ( )Tj EMC (the cellular spaces of)Tj /Span<>> BDC ( )Tj EMC (the pelvis )Tj 0 Tw T* [(used by respondents in e)-14.8(xtraper)-36.9(itoneal rectal w)12.1(ounds)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7902 56.0378 Tm (108)Tj ET endstream endobj 946 0 obj <>stream AdobedC     '$''''$25552;;;;;;;;;;4 4  y!16s3"AQRSa#ETqu2U $%&'()*45789:BCDFGHIJVWXYZbcdefghijrtvwxyz?ЪKMwj>؊u7[fj}H\(iAJ^W%tJ|JŜ(8R2K)%(JRJVR:Jj'S_6y 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VwHkzPЪw6}ĥio!fO"6d ƣɑDK)mJtd^eq4 ]7niwwg ͧ&f"UvK6IİIDIIDW!y=IzZsojRP+Iܫe(&8 >1ffhmy;tZd)p!La*Sdwl.K&Ԥ'xi--"1SXx0G`0l6|nx >7<{ =Ύ#CY%w_QYC"Ǹ`\9#Ǥ`^xݘ38 6|\Gc5FluE}QHj1sǸ(Eϕ6>7<{nxf=$5.(46|nx >7<{<6|nx x1|.;ycIΎY{>7<{ =ύ჊0l6|nx pҒiIčsydѪ6@t} $\g妉j )"2M|jӌiVN-"Rȉ$f\}<(dGueyg /26$JJ*[s1-"\U7*FTĔ)-8y8i5apBUPˍg I̔3.YJ* @ݦ٤B*)--WrI2R^1SI?Ö &X # a3Jm!W$Gg$"-d#-B9 d#-B9 d#- !Ž-%'zdp)SxuZ2l~re 2#ZNJ⑐t-n2Ζ- G:[ sC%Mؽ]WkG:[t-n8Z9 ps@hKpΖ Г~U[ir2C^B9 d#-B9 d#-B9 psBU*ɦ3I&I/q򃅏 YZf?,ٚ_<V!n2Ζ!n2Ζ!n2Ζ9w523x0ҪUIF}52%2UĮx=pՈl-%§,“~+ȅ:ѱLѻ2A^ ljF! $|2\:aETmkCnLuiD(22~>\I/_~{$f6Sj~G\H[|iukn 2߰ƺƟ6 VwHkzu(ӪMZm%%Ʋ̲MH;ȏT-uFlh5>2\n H-  LVҖ+DCW g&%n^R[qZI/xb0(qWB2*xxQ'q643/*UjK樒ԗbY :YT5Bq=G'^ Fyk<02]*QdVXn69`#^69`#^8>l_j0d9}2׺]8'ϯtEx']8}{ !6o,rCWϯtOG>q=G'^siSZAf#xs(pɖ/RI;lԞqp83ѓTx}{sg`ЖuI>DLXo3 -Y!@Ъ֔!sm M0ɨJNʹd[3fJ5ޒÙxi*zra^2J͹33<;aҭ US" 8I4hI!5t\z-FK.J,IykX~5k)e=3"y<,35;&n{ %Oɯ!yHVX(&RDJ_kfs5n4q$m%BI).a=#p^і4iL#j gt@eѪ-]:lG"4n-IderD|=- .ܸQ8ѡq$p(2УT"hfYɞ-[27R`>VW4zv %jL2&3f}I&Wx6kKX$U$px\*l#W_=qB<H[tv 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#$%'()*36789:CDEFGHIJVWXYZcdefghijtuvwxyz?Ъ8%%XyDCﴧԧm$T [냀9in:L4Ͳt漣] tTx$|SaCC-(և D0U23PѪ慓\LQ4VZPx-ժ`'{o=ބ* =pIBh r-y1D8R[2VL*7"b]~1C4J&t -͹:TJS$VQ:Њ/O~ hEpo4"x7߃\ ƄOz{^)Zo^(ʚr(*sFЊ/O~ hDo4"7߃< ƄOz{sF(WY4׊abQ`Nk ƄOz{cB+x=1^Њ/O~ hDok&%!J(,Ѷ4"x7߃\ ƄWz{cB'x=1^yvi6ڜxΊs v>N1^,I#ɩW^Њ/O~ hDo4"7߃< FI39QE2*Q:t,ҪԔ$:Um-J0ġ %.$Dy YCL$(<H^\DPT-m,ى.$ư;|0Ԋmx}V{ZLh>M`Ul:իB6ޡqXeӪ^iZ[NF fI-3|A8ҒBd!Ḙwhi8*Jt"gKc1.̒FULΡqPQ TZNF}mRVԙ(¶Sed@m\W| gmx|A֭Zz~z@Ԫ\&W,IA R֩SDEL5:mg'Pm*5̞KIQ(e2IFIlpH23rTSʳG" 'ƺhB^6 uHZclɇ7]=sP=~ P=~ P=~ P=~ P=~2};y6 Pt(:ȔK3>F\b1 SĵR'Kd"MJ#scU*uj=~ P=~ >zN|;ڝ1@;ڝTyew6\:u!48zNzNzNzNzNzN}emzڍ,-8|;ڝ1@;ڝ0w;ajwjwqƦ,.Rdp{ il!d'qw;ajwjwx# * 4ժܹ$KEmT3Ϋ]fj%%TN}2 +D,lmm4x64):#3*2Tc_ehi)D 5KGE,RےL{OMMiszV{ZLh>I`UlJ٫DP߆P֪ gnKc1. >It&gBY:',zФDlA$6$$Υ%TSbXDT#y I¶Sed@M\W| gmx|A֭ZzaתZnrvGCfnUL#* %qPemr+3e hVgBi1ؖ܅TMRh[.(DJ3:E@[;r]I`vv`?ѕ)$ES:jz-1Fq &i*Jn)P OtcI|=h>I`Ul:իBP2Ъvn:dcBM(}i#*ct XM05JJte*32oKDKE]rSA*@Jj")qIJУM:#Dd>ǂs$ĺDO;YNx0%+x $w ;\ⷀNxo6}ŶM+Iddy%%aHгM!58TN Sٽ #'8 4U*3:j.[a'tKewD[a'tKVI t ;y7UٔKUjiNtx $wLNtx $wLNtx $wL.Pi8eq.L].IwDo.[atKewDoqnĻQ X7N.,]ⷀ.x0%+x $w]ⷀ.tx8FښRΕQHhѪi$ȔD#,=T(a'-Nô׳)% Y7;>}G,W!(E^uV6ޡqXeӪ'$L+,`FMFX%SDYc1svVĘWdCfid4Di<2 @rSItu6jj:Q5ADBBiAGT֘ōծAV/H|t aΗ >YqRȆyp)ǐڍBR'LK88dq]JKM&IիNXH2ĩ'j"J%4L ꎆ,z@,|taΖGV^O$Zygt aΗ Y;X0gKGøZ["XL3eQ5/H|t aΗ >Y:^){=Ձ4IJsC@ԪxumO8JRyETp#ʑg^!nB4LY%,Sj^C')&ٞ %5H=>6QBcL8)6Y&6ȩuJ''q9'(sQ$"kgnKc1;|0Պ>Zmx}V{ZLh>I`Ul:իDP2ժT(N QzH()pzԺ$ECPzR,<Z`"RM)I(,@2.$ư(;|0Ԋ᭕x}V{ZLh>I`Ul:իBP2֪*H4(*cE# D+ Y yE!XwTV(ʓIT1 rKSsLZT9ZBRTgWt<"_eiyt%-tP]52*y]6%XGYYDPt8ۚLz )ϝEWpʼ>|+e=я&VMQ$w}*vWjա iw~V@ת|RCʱR3m QkR+IIe>+[!n'$I<´1 \mkxYK3L"iI"5eUB`gjTE+i %%N2je8!G0 Kv1(2U 5TtdQӕ&\D^)FBtT:Td1do:t:le NN|ϝӟ;0bzsuF ON|QvյnQӟ;'>wT`ꁉϝI+ی}y>+mZҦ$}ON|ϝӟ;0bzsu@Qh׮igiϝ1=9bzsu@P1=9@%,8zڈVո 8f_;U`;''>wT NN|P199brsuF8&3=JR ,Y4Ъ#„rr4̯(DIGKKef(#:sQIʔl(&=L/IAH&:"[JD4ie9.N;lPI-Y4揯'I}qRtP,*Z t>Mlwq&5E>Uu n¶Sed@m\W| gmx|A֭ZzaѪ)7xqMbԢqH%x#MJFP3wefV'QMSR>2*Ҍ cK~:jRRlg@N S}p|cQ6FjBJn*v8"R*U[)}i2otw}Y6+CQU> Vl OCҪ%ϙ:NL[2L% F"3:Ẍ́2z./]G2"<,y-$@-Ѵ7EF!gr (쪡eP̍ԥF{ 3I 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gnkc1. "ke^l9GWΠ>M`R#2-Y&Y I8f`,(n OC~@ԪrN8iNۏ(iJ"2#&>hXd ՀJi=pN P *aP<N`0U234Mlwq&5E>Uw n|s. ɑ1jE#Si5A6qpy*)8'gi2hWa `}G,W!*&(xtb\,iT4E&T5rs:%N9L:K9*NAzaժӕN](gh Ȋ!Q+Spѳ% JYUHz.$ǰ(;|0Ԋmx}F>Y71p眶ߛR=IjQF?(Qz%E`Dd{fS.pj烈^72Ԛ*C N(q F)hRp%AJ9ͦ\ 8cDj5v7HEI @-?ۊ(ЪgcSj!ekqm5IdN,U r%Y& mF1CeH4RZ M':JGbTpp~ p ZP҄kNi:IL3DuèT!̟b f |+,W1b?Bq^P.<˅ Cff|d f |+|Oб\Fc2~3ψ#"e d f |+|cOб\Fc8$-HRkqK$#Tݗ)< SS`VT$6A:L>`4,W1'X#1?Bq|+б\FaZt7[6uҡћJ:NHjnEC)>zIdEmFIӐqb?Bq0+б\F`3>`4,W|Rj6eE!Ju8ÀѪ9G)vH~M58Dh^M Azd8P,cd)ai)Du>KF2, QT7`Ry$ZCm@#m-"ii0KHFZC'ĻÍk&4Ӛ>iim@#m-"ii0KH*SzG|tȕ232#3ep % +mi%%Ixm@#m- `0KHm<><3+|mԵ""1d~CԴq 5J9t9>0 - `0KHm@#m-"IˌZan.I S$T2:cii0KHFZD 6ii0KHFZCEDCҪ> G![ypp:iܑ9'1$9jKZ6q2#3Q&@^Y)m&:VQ]Y BJ*Gޙ\L7 cIi*%v} fJ`=J&V(ҕ`0X%iRAX&{ADJml P'jX3"M2O'QKqu)F%)芛BHd¬):JH}Ӫȓ#e XAtQ4pPSvR`rQ {j6"raMjPf(DLASqkeJL}zFj]ʩ% HZj. lJnPҔLrRxU 7PJ=UNPYߕab+Pq"Q(Pc$Ip4ĝ Kl R U3:Ԫժ endstream endobj 955 0 obj <>stream endstream endobj 954 0 obj <>stream endstream endobj 944 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.102 Tw 10 0 0 10 42.5197 274.2439 Tm (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \b\017\030\031\030\020\017\004\036\f\022\017\005 \f\021\026\ \032 \f\023\036\006\017\026\035\017\f\021\024\r \027\036 \r\035\017)Tj 0 Tw (-)Tj 0.021 Tw 0 -1.218 TD (\016\035 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \007\017\f\021\026\035\034\027\024\020\024 \024\ \021\n\t\r\026\027\017\016 \022\017\001\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030 )Tj -0.027 Tw T* (\021\036\b\027\017\004\036\f\022\024\020\024 \r\026\030\017\026\027\021\026\ \030\036\026\035\017\026\006\017\017 \007\026\027\027\024\020\024 \220\ \035\036\n\036\027\021\026 )Tj 0 Tw T* (\025\024\027\006\036\023\006\017\017 \(\024\007\027\024\235\026\022\021\024\ \030\027\t\005 )Tj /T1_2 1 Tf -0.053 Tc 0.053 Tw [(AN)-33(O)-37(V)-11(A)]TJ /T1_1 1 Tf 0 Tc 0 Tw 14.582 0 Td (, )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,56\).)Tj 0.028 Tw -14.582 -1.218 Td (\222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\ \r 14/75 \017\035\017 19 \(11; 29\) % \027\036 )Tj 0 Tw T* (\r\t\023\024\035\027\016\033\021 \007\017\f\021\026\035\034\027\024\036 \ \024\021\n\t\r\026\027\017\036 \022\017\001\022\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj /T1_3 1 Tf 0.063 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2365:)Tj /T1_1 1 Tf ( \253\025\026\022\017\n \f\023\024\f\024\002\024\n \200\t \r\t\023\024\035\ \027\016\036\021\036 \023\036\030\017)Tj 0 Tw (-)Tj 0.309 Tw 0 -1.218 TD [(\027\036\026\035\034\027\024\036 )0.6(\007\030\036\027\017\030\024\r\026\027\017\036 )0.5(\022\035\036\021\004\026\021\024\004\027\t\b )0.6(\023\030\024\f\021\030\026\027\f\021\r )]TJ 0 Tw T* (\021\026\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017\ \023\030\016\n\024\005 \022\017\001\022\017?\273)Tj 0.002 Tc 0.594 Tw T* (\215\030\036\007\023\024\004\017\021\026\036\n\t\036 \030\036\f\023\024\027\ \007\036\027\021\026\n\017 \f\023\024\f\024\002\t \030\031\021\017\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.204 Tw T* [(\027\024\020\024 \007\030\036\027\017\030\024\r\026\027\017\016 \022\035\ \036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\021\ \r \021\026\026)2( )]TJ 0.077 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\031\036\n\t\b \211\204\215 \f\021\026\021\017\f\021\ \017\004\036\f\022\017 \027\026\004\017\n\024 \027\036 \030\026)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 1.002 Tw T* [(\035\017\004\026\035\017\f\034 \(\022\030\017\021\036\030\017\005 \205\017\ \001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\ \026,)2( )]TJ /T1_2 1 Tf 0 Tc 0 Tw T* (p)Tj /T1_1 1 Tf 0.002 Tc 0.182 Tw /Span<>> BDC 0.48 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,077\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\). \222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\ \024\r \027\026\017)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.364 Tw -0.48 -1.218 Td (\002\024\035\036\036 \004\026\f\021\024 \023\030\017\n\036\027\016\035\f\ \016 \002\017\035\026\021\036\030\026\035\034\027\t\005 \023\026\030\026\ \030\036\022)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.077 Tw T* [(\021\026\035\034\027\t\005 )0.5(\f\023\024\f\024\002 )0.5(\007\030\036\027\017\030\024\r\026\027\017\016)]TJ /Span<>> BDC ( )Tj EMC 13.201 0 Td [(\227 )0.5(54/75 )0.5(\017\035\017 )0.5(72 )0.5(\(60;)2( )]TJ 0.331 Tw 10.043 19.485 Td (82\))Tj /Span<>> BDC ( )Tj EMC 1.503 0 Td [(%. )0.5(\215\030\036\f\026\022\030\026\035\034\027\t\005 )0.5(\f\023\024\f\024\002 )0.5(\r\t\002\030\026\035\017 )0.6(15/75 )0.6(\030\036)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.176 Tw -1.503 -1.218 Td (\f\023\024\027\007\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 20 \(12; 31\))Tj /Span<>> BDC ( )Tj EMC 11.639 0 Td [(%, \021\024\020\007\026 \022\026\022 \004\036\030\036 \030\026\027\031)2( )]TJ 0.179 Tw -11.639 -1.218 Td [(\007\030\036\027\017\030\024\r\026\035\017 )0.6(2/75 )0.5(\b\017\030\031\030\020\024\r)]TJ /Span<>> BDC ( )Tj EMC 12.409 0 Td [(\227 )0.5(3 )0.5(\(0,3; )0.5(9\))]TJ /Span<>> BDC ( )Tj EMC 5.621 0 Td [(%. )0.5(\025\030\024\n\036)2( )]TJ -0.012 Tw -18.031 -1.218 Td (\021\024\020\024, 4/75 \030\036\f\023\024\027\007\036\027\021\026 \017\035\ \017 5 \(1; 13\) % \(3/22 \030\036\f\023\024\027)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.057 Tw T* (\007\036\027\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (4 \211\204\215 \017)Tj /Span<>> BDC ( )Tj EMC (1/9 \030\036\f\023\024\027\007\036\027\021 \f)Tj /Span<>> BDC ( )Tj EMC [(5 \211\204\215\) \007\024\023\031\f\022\026\035\017)2( )]TJ 0.042 Tw T* [(\r\024\n\024\032\027\024\f\021\034 \024\021\022\026\026 \024\021 \024\002\ \016\026\021\036\035\034\027\024\020\024 \007\030\036\027\017\030\024\r\ \026\027\017\016)2( )]TJ -0.006 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r \021\026\026 \023\036\030\017\027\036\026\035\034\027\t\n \007\ \024\f\021\031)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.031 Tw T* (\023\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\). \200\t\002\024\030 \f\023\024\f\024\002\026 \023\026\030\026\030\036\ \022\021\026\035\034)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.094 Tw T* [(\027\024\020\024 )0.6(\007\030\036\027\017\030\024\r\026\027\017\016 )0.6(\017\035\017 )0.6(\024\021\022\026 )0.6(\024\021 )0.5(\027\036\020\024 )0.6(\027\036 )0.6(\026\r\017\f\036\035 )0.6(\024\021)2.1( )]TJ 0.085 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \f\021\026\032\026 \ \f\023\036\006\017\026\035\017\f\021\026 \(\024\007\027\024\235\026\022\021\ \024\030\027\t\005)2( )]TJ /T1_2 1 Tf -0.051 Tc 0.051 Tw T* [(AN)-33(O)-37(V)-11(A)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw 2.543 0 Td (, )Tj /T1_2 1 Tf 0 Tc 0 Tw 0.422 0 Td (p)Tj /T1_1 1 Tf 0.002 Tc /Span<>> BDC 0.48 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,26\).)Tj /T1_3 1 Tf 0 Tc -0.045 Tw -3.445 -2.436 Td [(\026\002\212\006\002\217 )0.5(\2366:)]TJ /T1_1 1 Tf [( \253\200 \b\024\007\036 )0.5(\r\t\023\024\035\027\036\027\017\016 )0.5(\023\036\030\017\027\036\026\035\034\027\024\020\024 \007\030\036)]TJ 0 Tw (-)Tj 0.139 Tw T* (\027\017\030\024\r\026\027\017\016 \022\035\036\021\004\026\021\024\004\027\ \t\b \023\030\024\f\021\030\026\027\f\021\r \021\026\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036)Tj 0 Tw (-)Tj -0.061 Tw T* (\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\ \016\n\024\005 \022\017\001\022\017, \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\031\033 \020\035\031\002\017\027\031 )Tj -0.014 Tw T* (\031\f\021\026\027\026\r\035\017\r\026\036\021\036 \023\026\030\026\030\036\ \022\021\026\035\034\027\t\005 \007\030\036\027\026\032 \(\f\n\) \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\022\017\n )Tj 0 Tw T* (\024\030\017\036\027\021\017\030\024\n \023\024\035\034\031\036\021\036\ \f\034 \007\035\016 \220\021\024\020\024?\273)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.08 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \205\033\031\024\031\240\013 \203\031\032\026\022\032\031\021\020\025\022\ \t \032\027\024\033\031\025\030\027\025\023\020\026\022 \030\022\021\027\ \032\024\022\031\025\025\031\235 \n\031\f\031\024\023\031\026\013 \025\020\ )Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025)Tj 0 Tw (-)Tj 0 -1.2 TD (\024\n\031\235 \033\031\026\031\212\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\024\023\032\r\n\023\022\021\025\013\200 \211\240\206\004\ \202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.01 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.017 Tw 3.306 0 Td [( M)-2(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(f)-13.4(o)-3(r)-18.5(m)1.3(i)3.9(n)-0.6(g a)]TJ /Span<>> BDC ( )Tj EMC [(d)-3(i)-2.9(v)2.3(e)-6(r)-14.9(s)-12.5(i)-2.9(v)2.3(e c)2.8(o)-5.3(l)-1.5(o)-1.1(s)-14.8(t)-3(o)-4(my b)-2.4(y r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-6.9(n)-0.7(t)-32.8(s a)-9.1(t v)6.3(a)-4.2(r)-39(i)-1.4(o)-3.4(u)-4.4(s le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-2.9(i)-1.8(c)3.2(a)-4.5(l c)3.2(a)-4.2(r)-2(e f)-13.4(o)-3(r n)-2.4(o)-4(n)-13.4(-)-29.4(d)-5.3(e)-22(s)-14.8(t)-9.6(r)-9.1(u)-3.7(c)-32.4(t)-29.1(i)-2.9(v)2.3(e e)-32.4(x)-32.5(t)-9.6(r)3.4(a)-5.2(p)-11.3(e)-6(r)-39(i)]TJ 0 Tw 46.792 0 Td (-)Tj 0.002 Tc -0.002 Tw -50.098 -1.2 Td [(t)-1(o)-2(ne)-5.5(a)-2.5(l)2( re)-8.9(c)-30.4(ta)-2.5(l)2( w)4.2(o)-1.4(u)2.6(n)-2.8(d)-3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 158.9902 693.581 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 221.3524 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 266.7067 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 312.061 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 357.4153 693.581 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 402.7697 693.581 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 450.9586 693.581 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 672.7618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 672.5118 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 672.5118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 221.3524 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 312.061 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 357.4153 672.5118 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 402.7697 672.5118 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9586 672.5118 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 661.2925 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 661.0425 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 649.5813 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 661.0425 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 661.0425 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 661.0425 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 661.0425 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 649.8313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 638.37 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 649.5813 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 649.5813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 649.5813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 649.5813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 649.5813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7086 649.5813 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 638.37 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 638.12 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 626.6587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 638.12 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 638.12 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 638.12 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 638.12 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 626.9087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 607.7087 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 158.7402 626.6587 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 221.3524 626.6587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 266.7067 626.6587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 312.061 626.6587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 357.4153 626.6587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 402.7697 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 450.7086 626.6587 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 496.313 607.7087 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 42.5197 607.4587 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 595.9974 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 607.4587 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 607.4587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 607.4587 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 607.4587 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 596.2474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 577.0474 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 158.7402 595.9974 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 221.3524 595.9974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 266.7067 595.9974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 312.061 595.9974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 357.4153 595.9974 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 402.7697 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 450.7086 595.9974 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 496.313 577.0474 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 42.5197 576.7974 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 565.3361 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 576.7974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 576.7974 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 576.7974 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 576.7974 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 565.5861 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 554.1249 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 565.3361 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 158.9902 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 565.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 565.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 312.061 565.3361 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 357.4153 565.3361 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 357.4153 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 402.7697 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7086 565.3361 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9586 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 554.1249 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 553.8749 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 158.9902 553.8749 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 221.3524 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 553.8749 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 402.7697 553.8749 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9586 553.8749 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 542.6636 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 542.4136 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 158.9902 542.4136 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 158.9902 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 221.3524 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 221.3524 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 266.7067 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 542.4136 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 402.7697 542.4136 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 402.7697 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9586 542.4136 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9586 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 521.6023 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 521.3523 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 158.9902 521.3523 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 221.3524 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 266.7067 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 312.061 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 357.4153 521.3523 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 402.7697 521.3523 cm 0 0 m 48.189 0 l S Q q 1 0 0 1 450.9586 521.3523 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 61.3765 684.9464 Tm (\255\212\002\217\002\206 \226\002\006\214\t\006\002\004\b\t\235 )Tj 2.548 -1.2 Td (\220\002\f\002\217\003\002\214\013)Tj 11.571 0.6 Td (\255\t\214\002\f\013)Tj 6.523 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 7.776 0.001 Td (\t)Tj /T1_3 1 Tf 4.881 -0.001 Td (\026\217\r\n\002)Tj /T1_1 1 Tf -52.279 -2.033 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 17.758 0 Td (N)Tj /T1_3 1 Tf 6.489 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_4 1 Tf 5.846 0.001 Td (\226)Tj /T1_3 1 Tf 5.568 -0.001 Td (75)Tj /T1_1 1 Tf -52.948 -1.433 Td (\212\r\031- \017\035\017 \024\007\027\024\f\021\r\024\035\034\027\026\016\ )Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (9)Tj 5.669 0 Td (6)Tj 5.669 0 Td (5)Tj 5.669 0 Td (5)Tj 5.004 0 Td (0,45*)Tj 6.439 0 Td (25)Tj /T1_2 1 Tf -35.957 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.497 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(17; 64\))Tj 5.669 0 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(10; 58\))Tj 5.919 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(6; 50\))Tj 5.419 0 Td (56)Tj /Span<>> BDC ( )Tj EMC (\(18; 89\))Tj 11.693 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(23; 45\))Tj -51.245 -1.433 Td (\212\r\031\f\021\r\024\035\034\027\026\016 \023\036\021\035\036\r\026\016\ )Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.482 0 Td (11)Tj 5.919 0 Td (9)Tj 5.669 0 Td (2)Tj 5.669 0 Td (2)Tj 4.754 0 Td (0,035*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 622.5573 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 419.3252 619.8933 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,034)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 612.9573 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 419.3252 610.2933 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,049)Tj 6.289 2.4 Td (24)Tj /T1_2 1 Tf -35.957 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.497 0 Td (46)Tj /Span<>> BDC ( )Tj EMC (\(23; 70\))Tj 5.669 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(21; 72\))Tj 6.169 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(1; 34\))Tj 5.419 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(2; 64\))Tj 11.443 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(22; 44\))Tj -51.245 -2.4 Td (\210\007\027\024\f\021\r\024\035\034\027\026\016 \022\024\027\006\036\r\026\ \016)Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (1)Tj 5.669 0 Td (0)Tj 5.669 0 Td (8)Tj 5.669 0 Td (0)Tj 4.754 0 Td (0,003*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 591.8961 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 419.3252 589.2321 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,029)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 413.0195 582.296 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 419.3252 579.632 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013)Tj 6.539 2.4 Td (9)Tj /T1_2 1 Tf -36.207 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.997 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 25\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.169 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(15; 34\))Tj 6.169 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 11.443 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(6; 22\))Tj -51.495 -2.4 Td (\203\036 \r\f\036\020\007\026 \235\024\030\n\017\030\031\033)Tj /T1_2 1 Tf 17.821 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (3)Tj 5.669 0 Td (5)Tj 5.669 0 Td (7)Tj 5.669 0 Td (2)Tj 5.004 0 Td (0,46*)Tj 6.439 0 Td (17)Tj /T1_2 1 Tf -35.957 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.747 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(2; 36\))Tj 5.669 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(7; 54\))Tj 5.419 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(12; 60\))Tj 5.919 0 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(2; 64\))Tj 11.559 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(14;34\))Tj /T1_2 1 Tf -51.362 -1.433 Td (p)Tj /T1_1 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 17.832 0 Td (p)Tj /T1_1 1 Tf 14.133 0 Td (0,0032)Tj -31.965 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017)Tj /T1_2 1 Tf T* (V)Tj /T1_1 1 Tf ( \025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 17.831 1.2 Td (V)Tj /T1_1 1 Tf 12.19 0 Td (0,34)Tj /Span<>> BDC ( )Tj EMC (\(0,16; 0,53\))Tj /T1_2 1 Tf 7 0 0 7 42.5197 509.8676 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ 0 -1.2 TD (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020; \032)Tj 4.081 0 0 4.081 303.4887 503.7986 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 313.8094 501.4676 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.055 Tw 9 0 0 9 42.5197 482.1636 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\031\f\t \032\027\024\033\031\025\030\027\025\023\031\021, \033\032\ \022\026\027\025\t\005\212\022\200 \023\032\020\025\024\f\005\026\022\025\ \020\f\017\025\031\027 \r\213\022\021\020\025\022\027 \032\020\025\013 \033\ \032\t\026\031\235 \n\022\213\n\022 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\027\030\027\024\023\032\r\n\023\022\021\025\013\200 )Tj 0 Tw 0 -1.2 TD (\211\240\206\004\202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.136 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.109 Tw 3.437 0 Td [( )0.5(T)-6.3(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC 2.062 0 Td [(p)-2.8(r)-2(o)-5.3(p)-9.1(o)-3(r)-41.9(t)-29(i)-1.4(o)-4(n )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 5.686 0 Td [(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.2(e)-7(n)-0.6(t)-32.9(s )0.5(u)-4.4(s)-12.5(i)3.9(n)-0.6(g )0.6(t)-9.6(r)3.3(a)-5.1(n)3.7(s)4.8(lu)0.7(m)1.3(i)3.9(na)-4.5(l )0.5(r)-2(e)-10.8(c)-32.4(t)-2(a)-4.5(l )0.5(w)2.3(o)-3.4(u)0.6(n)-4.8(d)-5.8(s )0.5(s)6.8(u)-4.8(t)-1.1(u)1.6(r)-39(i)3.9(n)-0.6(g )0.5(f)-13.4(o)-2.9(r )0.5(n)-2.4(o)-4(n)-13.4(-)-29.5(d)-5.2(e)-22(s)-14.8(t)-9.6(r)-9.1(u)-3.7(c)-32.4(t)-29.1(i)-2.9(v)2.3(e )0.6(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.3(e)-6(r)-39(i)-3.3(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l )0.5(r)-1.9(e)-10.9(c)-32.4(t)-2(a)-4.5(l )]TJ -0.002 Tc 0.002 Tw -11.185 -1.2 Td [(wo)-5.4(u)-1.4(n)-6.8(d)-7.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 445.2617 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 161.8248 445.2617 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 224.187 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 269.5414 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 314.8957 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 360.25 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 405.6044 445.2617 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 450.9587 445.2617 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 414.8424 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 414.5924 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 161.8248 414.5924 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 224.187 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5414 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 314.8957 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 360.25 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 405.6044 414.5924 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9587 414.5924 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 403.3732 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 403.1232 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 391.6619 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.8248 403.1232 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 403.1232 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 403.1232 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 391.9119 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 380.4507 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.5748 391.6619 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 161.8248 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 391.6619 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 391.6619 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 380.4507 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 380.2007 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 368.7394 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.8248 380.2007 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 380.2007 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 380.2007 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 380.2007 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 380.2007 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 360.25 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 380.2007 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 368.9894 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 357.5281 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 161.5748 368.7394 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 161.8248 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 368.7394 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 368.7394 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 314.8957 368.7394 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 360.25 368.7394 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 360.25 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 368.7394 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 357.5281 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 357.2781 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 161.8248 357.2781 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 224.187 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5414 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 357.2781 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 357.2781 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 346.0668 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 345.8168 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 42.7697 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 161.8248 345.8168 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 161.8248 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 224.187 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 224.187 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 269.5414 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 345.8168 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9587 345.8168 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 325.0055 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 324.7555 cm 0 0 m 119.305 0 l S Q q 1 0 0 1 161.8248 324.7555 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 224.187 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 269.5414 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 314.8957 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 360.25 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 405.6044 324.7555 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 450.9587 324.7555 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 8 0 0 8 80.4135 436.6271 Tm (\200\006\t\214\r\b\r\b\t\r )Tj -3.999 -1.2 Td (\003\006\004\b\217\f\211\214\t\b\004\f\001\b\002\n\002 \210\230\t\004\b\ \t\235 )Tj 2.287 -1.2 Td (\006\004\b\013 \212\006\235\214\002\005 \220\t\230\220\t)Tj 13.807 1.2 Td (\255\t\214\002\f\013)Tj 6.523 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 7.599 0.001 Td (p)Tj /T1_3 1 Tf 4.704 -0.001 Td (\026\217\r\n\002)Tj /T1_1 1 Tf -52.279 -2.633 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 18.113 0 Td (N)Tj /T1_3 1 Tf 6.489 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_4 1 Tf 5.669 0.001 Td (\226)Tj /T1_3 1 Tf 5.391 -0.001 Td (75)Tj /T1_1 1 Tf -52.948 -1.433 Td (\212\026, \023\030\017\n\036\027\016\033)Tj /T1_2 1 Tf 18.175 0 Td (n)Tj /T1_1 1 Tf 6.732 0 Td (7)Tj 5.419 0 Td (16)Tj 5.669 0 Td (13)Tj 5.919 0 Td (3)Tj /T1_4 1 Tf 5.641 0 Td (\226)Tj /T1_1 1 Tf 5.447 0 Td (39)Tj /T1_2 1 Tf -35.602 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.497 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(15; 49\))Tj 5.669 0 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(58; 92\))Tj 5.669 0 Td (59)Tj /Span<>> BDC ( )Tj EMC (\(39; 77\))Tj 5.669 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(12; 65\))Tj /T1_2 1 Tf 5.719 0 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 414.4368 385.6993 Tm (2-3)Tj /Span<>> BDC 8 0 0 8 420.7425 383.0353 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005)Tj 4.353 0 Td (52)Tj /Span<>> BDC ( )Tj EMC (\(41; 63\))Tj -51.245 -1.433 Td (\203\036\021, \027\036 \023\030\017\n\036\027\016\033)Tj /T1_2 1 Tf 18.175 0 Td (n)Tj /T1_1 1 Tf 6.482 0 Td (17)Tj 5.919 0 Td (4)Tj 5.669 0 Td (9)Tj 5.669 0 Td (6)Tj 11.089 0 Td (36)Tj /T1_2 1 Tf -35.602 -1.433 Td (f )Tj /T1_1 1 Tf (\(%\))Tj 5.614 0 Td (71)Tj /Span<>> BDC ( )Tj EMC (\(51;85\))Tj 5.803 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(8; 42\))Tj 5.536 0 Td (41)Tj /Span<>> BDC ( )Tj EMC (\(23;61\))Tj 5.553 0 Td (67)Tj /Span<>> BDC ( )Tj EMC (\(35; 88\))Tj 11.339 0 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(37; 59\))Tj /T1_2 1 Tf -51.245 -1.433 Td (p)Tj /T1_1 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 18.186 0 Td (p)Tj /T1_1 1 Tf 11.548 0 Td (0,004)Tj -29.734 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017)Tj /T1_2 1 Tf ( V)Tj /T1_1 1 Tf ( )Tj T* (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 18.186 1.2 Td (V)Tj /T1_1 1 Tf 9.355 0 Td (0,42)Tj /Span<>> BDC ( )Tj EMC (\(0,22; 0,61\))Tj /T1_2 1 Tf 7 0 0 7 42.5197 313.2709 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ T* (\032\020\024\033\032\027\030\027\f\027\025\022\t; \032)Tj 4.081 0 0 4.081 92.3589 307.2019 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 102.6796 304.8709 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.552 56.0378 Tm (107)Tj ET endstream endobj 942 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.139 Tw 10 0 0 10 70.8661 724.8299 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\ \226\216\024\b)Tj /Span<>> BDC ( )Tj EMC 12.849 0 Td (\002\036\030\020\026\), \022\024\n\023\034\033\021\036\030\027\024\005 )Tj 0.447 Tw -12.849 -1.218 Td (\021\024\n\024\020\030\026\235\017\017 \(\022\030\017\021\036\030\017\005\ \205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD (\032)Tj /T1_0 1 Tf 0.541 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\ \226\216\024\b\002\036\030\020\026\). )Tj 0.117 Tw T* [(\215\030\036\017\n\031\013\036\f\021\r\036\027\027\t\005 )0.5(\r\t\002\024\030 \023\030\024\022\021\024-, \030\036\022\021\024\f\022\024\ \023\017\017 )0.5(\027\026)]TJ 0 Tw (-)Tj 0.187 Tw T* (\002\035\033\007\026\035\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (5 \211\204\215 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f\024 \021\030\036\021\034\017\n \211\204\ \215 )Tj 0.366 Tw T* (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 5.83 0 0 5.83 245.2554 667.2699 Tm (3-5)Tj 0.366 Tw /Span<>> BDC 10 0 0 10 253.1374 663.9399 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,038 )Tj 0.105 Tw -18.227 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \). \221\024\020\007\026 \022\026\022 \235\017\002\030\024\022\024\035\024\ \027\024)Tj 0 Tw (-)Tj 0.326 Tw 0 -1.218 TD (\f\022\024\023\017\016 \002\t\035\026 \023\030\036\007\023\024\004\021\017\ \021\036\035\034\027\t\n \n\036\021\024\007\024\n \007\017\026\020\027\024\ \f)Tj 0 Tw (-)Tj 0.168 Tw 0 -1.218 TD (\021\017\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\036\021\r\036\030\021\024\n \211\204\215 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 )Tj 0.328 Tw T* (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj 5.83 0 0 5.83 244.4936 618.5578 Tm (2-4)Tj /T1_0 1 Tf 0.328 Tw /Span<>> BDC 10 0 0 10 252.0492 615.2278 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,018, )Tj /T1_1 1 Tf 0 Tw -18.118 -1.218 Td (\032)Tj 5.83 0 0 5.83 75.6461 606.3798 Tm (3-4)Tj /T1_0 1 Tf 0.024 Tw /Span<>> BDC 10 0 0 10 83.2017 603.0498 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \). \222\021\026\021\017\f\021\017\004\036\f\022\017 )Tj 0.019 Tw -1.234 -1.218 Td (\027\026\017\n\036\027\034\001\026\016 \007\024\035\016 \r\t\002\024\030\ \026 \022\024\n\023\034\033\021\036\030\027\024\005 \021\024\n\024\020\030\ \026\235\017\017 )Tj 0.11 Tw T* [(\022\026\022 )0.5(\024\f\027\024\r\027\024\020\024 )0.5(\n\036\021\024\007\026 )0.6(\007\017\026\020\027\024\f\021\017\022\017 )0.6(\200\002\217\215\025 )0.5(\027\026\002\035\033\007\026)]TJ 0 Tw (-)Tj 0.026 Tw T* (\035\026\f\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (2 \211\204\215 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\ \226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj 5.83 0 0 5.83 75.6461 557.6678 Tm (2-3)Tj /T1_0 1 Tf 0.276 Tw /Span<>> BDC 10 0 0 10 83.2017 554.3378 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001; )Tj /T1_1 1 Tf 0 Tw (\032)Tj 5.83 0 0 5.83 133.2049 557.6678 Tm (2-4)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf 0.276 Tw 10 0 0 10 143.7267 554.3378 Tm (=)Tj /Span<>> BDC ( )Tj EMC (0,006; )Tj /T1_1 1 Tf 0 Tw (\032)Tj 5.83 0 0 5.83 188.6421 557.6678 Tm (2-5)Tj /T1_0 1 Tf 0.276 Tw /Span<>> BDC 10 0 0 10 196.1977 554.3378 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 )Tj 0 Tw -12.533 -1.218 Td (\207\024\027\235\036\030\030\024\027\017\).)Tj -0.025 Tw T* [(\210\007\017\027 )0.5(\030\036\f\023\024\027\007\036\027\021 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 7.91 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\017\n )0.5(\f\021\026\032\036\n )0.5(20 )0.5(\035\036\021 )0.6(\f\004\036\035 )]TJ 0.265 Tw -7.91 -1.218 Td (\r\024\n\024\032\027\t\n \023\030\017\n\036\027\036\027\017\036 \n\026\020\ \027\017\021\027\024-\030\036\024\027\026\027\f\027\024\005 \021\024)Tj 0 Tw (-)Tj 0.138 Tw T* (\n\024\020\030\026\235\017\017 \007\035\016 \007\017\026\020\027\024\f\021\ \017\022\017 \200\002\217\215\025, \027\036\f\n\024\021\030\016 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.017 Tw T* (\f\024\022\031\033 \030\026\f\023\030\024\f\021\030\026\027\036\027\027\024\ \f\021\034 \235\036\030\030\024\n\026\020\027\017\021\027\t\b \017\027\024\ \030\024\007)Tj 0 Tw (-)Tj T* (\027\t\b \021\036\035.)Tj /T1_2 1 Tf 0.222 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2362)Tj /T1_0 1 Tf (: \253\025\026\022\024\005 \f\023\024\f\024\002 \235\024\030\n\017\030\024\ \r\026\027\017\016 \007\017\r\036\030)Tj 0 Tw (-)Tj 0.678 Tw 0 -1.218 TD (\f\017\024\027\027\024\005 \022\024\035\024\f\021\024\n\t \016\r\035\016\ \036\021\f\016 \023\030\036\007\023\024\004\021\017\021\036\035\034\027\t\ \n )Tj 0.268 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\024\n \(\007\024 \274 \024\ \022\030\031\032\027\024\f\021\017\) \r\027\036\002\030\033)Tj 0 Tw (-)Tj T* (\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\030\016\n\024\005\ \022\017\001\022\017?\273)Tj 0.516 Tw T* (\200\t\002\024\030 \n\036\021\024\007\024\r \235\024\030\n\017\030\024\r\ \026\027\017\016 \022\024\035\024\f\021\024\n\t \f\030\036\007\017 )Tj 0.15 Tw T* (\r\f\036\b \020\030\031\023\023 \211\204\215 \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \024\021\035\017\004\026\035\f\016 \(\022\030\017\021\ \036\030\017\005 )Tj 0 Tw T* (\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )Tj /T1_1 1 Tf 12.112 0 Td (\032)Tj /T1_0 1 Tf 0.352 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0032\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\), )Tj 0.093 Tw -12.112 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\004\017\n\024 \n\036\027\034\001\036 \b\017\030\ \031\030\020\017-\030\036\f\023\024\027\007\036\027\021\t \r\t)Tj 0 Tw (-)Tj 0.051 Tw T* (\023\024\035\027\016\035\017 \024\007\027\024\f\021\r\024\035\034\027\031\ \033 \022\024\035\024\f\021\024\n\017\033)Tj /Span<>> BDC ( )Tj EMC (\227 12 \(6; 22\) % )Tj 0.129 Tw 23.244 36.534 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC 2.494 0 Td [(1\). \216\017\030\031\030\020\017\004\036\f\022\017\005 \f\021\026\032 )0.5(\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 )0.5(\030\036)]TJ 0 Tw (-)Tj -2.494 -1.218 Td (\f\023\024\027\007\036\027\021\024\r \f\024\f\021\026\r\017\035)Tj /Span<>> BDC ( )Tj EMC (\227 16 \(12; 19\) \035\036\021.)Tj 0.569 Tw T* (\200\t\002\024\030 \007\r\031\f\021\r\024\035\034\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\f\021\r\024\035\034\027\024\005 \022\024\035\024\f\021\024\ \n )Tj 0.442 Tw 0 -1.218 TD (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \030\ \026\035\017\004\026\035\f\016 \f\030\036\007\017 \030\026\027\t\b )Tj 0.157 Tw 0 -1.218 TD [(\031\030\024\r\027\036\005 )0.5(\211\204\215 )0.6(\(\022\030\017\021\036\030\017\005 )0.5(\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )]TJ /T1_1 1 Tf 0 Tw 0 -1.218 TD (\032)Tj /T1_0 1 Tf 0.277 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035 \017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.277 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,003 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\ \226)Tj 0.372 Tw 0 -1.218 TD (\216\024\b\002\036\030\020\026\). \200)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \007\r\031\b\f\021\r\024\035\034\027\031\ \033 \022\024\035\024\f\021\024\n\031 )Tj 0.339 Tw 0 -1.218 TD (\f\021\026\021\017\f\021\017\004\036\f\022\017 \n\036\027\034\001\036 \235\ \024\030\n\017\030\031\033\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (4 \211\204\215, \004\036\n )Tj 0.116 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (2 \017)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\ \226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj /T1_0 1 Tf 5.83 0 0 5.83 308.087 618.5578 Tm (2-4)Tj 0.174 Tw /Span<>> BDC 10 0 0 10 315.9691 615.2278 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,034; )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 5.83 0 0 5.83 362.9075 618.5578 Tm (3-4)Tj 0.174 Tw /Span<>> BDC 10 0 0 10 370.7896 615.2278 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,049 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \), )Tj -0.018 Tw -6.748 -1.218 Td (\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \023\030\036\007\023\024\004\021\036\027\017\016 \024\007\ \027\024\f\021\r\024\035\034\027\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 36 \(15; 34\))Tj /Span<>> BDC ( )Tj EMC 21.351 0 Td (% )Tj 0 Tw -21.351 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj /T1_2 1 Tf 0.098 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2363:)Tj /T1_0 1 Tf ( \253\215\030\017\n\036\027\016\036\021\036 \035\017 \200\t \021\030\026\ \027\f\035\033\n\017\027\026\035\034\027\024\036 )Tj 0.076 Tw 0 -1.218 TD (\031\001\017\r\026\027\017\036 \007\036\235\036\022\021\026 \023\030\016\ \n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj -0.014 Tw T* (\027\024\n \(\007\024 \274 \024\022\030\031\032\027\024\f\021\017\) \r\027\ \036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017 \023\ \030\016)Tj 0 Tw (-)Tj T* (\n\024\005 \022\017\001\022\017?\273)Tj 0.187 Tw T* [(\222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\ \r \f\024\024\021\027\024\001\036\027\017\036, )0.5(\017\f\023\024\035\034\031\033)]TJ 0 Tw (-)Tj -0.079 Tw T* (\013\017\b \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \017\f\023\024\035\034\031\033\013\017\b, \021\030\026\027\f\035\ \033\n\017\027\026\035\034\027\024\036 \031\001\017\r\026\027\017\036 )Tj 0.193 Tw T* (\030\026\027 \023\030\016\n\024\005 \022\017\001\022\017 \027\036 \024\021\ \035\017\004\026\035\024\f\034 \024\021 \030\026\r\027\024\n\036\030\027\ \024\020\024 )Tj 0.106 Tw T* (\002\017\027\024\n\017\027\026\035\034\027\024\020\024 \030\026\f\023\030\ \036\007\036\035\036\027\017\016 \f)Tj /Span<>> BDC ( )Tj EMC (\024\032\017\007\026\036\n\024\005 \007\024\035\036\005 )Tj 0.051 Tw T* (50% \(\022\030\017\021\036\030\017\005 \f\024\020\035\026\f\017\016 )Tj /T1_1 1 Tf 0 Tw (\250)Tj 5.83 0 0 5.83 413.9756 472.4218 Tm (2\032)Tj 0.051 Tw /Span<>> BDC 10 0 0 10 419.6773 469.0918 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC /T1_0 1 Tf (0,729\). \210\007\027\026\022\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj -0.098 Tw -11.637 -1.218 Td (\027\t\b \211\204\215 \027\026\002\035\033\007\026\035\017\f\034 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\036 \030\026\ \035\017)Tj 0 Tw (-)Tj 0.218 Tw T* [(\004\017\016 )0.5(\004\026\f\021\024\021\t )0.5(\r\t\023\024\035\027\036\027\017\016 )0.5(\b\017\030\031\030\020\026\n\017-\030\036\f\023\024\027\007\036\027\021\026\ \n\017 )]TJ 0.085 Tw T* (\021\030\026\027\f\035\033\n\017\027\026\035\034\027\024\020\024 \031\001\ \017\r\026\027\017\016 \007\036\235\036\022\021\026 \023\030\016\n\024\005\ \022\017\001)Tj 0 Tw (-)Tj 0.075 Tw T* (\022\017 \(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\ \205\030\017\n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\). )Tj 0.139 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \b\017\030\031\030\020\017 2 \211\204\215 \030\036\032\036\ \r\t\023\024\035\027\016\035\017 \021\030\026\027\f\035\033)Tj 0 Tw (-)Tj 0.198 Tw T* [(\n\017\027\026\035\034\027\024\036 )0.6(\031\001\017\r\026\027\017\036 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017, )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 17.552 0 Td (\f\030\026\r\027\036\027\017\033 )Tj -0.032 Tw -17.552 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\f\023\024\027\007\036\027\021\026\n\017 3 \211\204\215, \020\007\ \036 \007\026\027\027\t\005 \023\024\007\b\024\007 \002\t\035 \023\030\036\ \007)Tj 0 Tw (-)Tj 0.026 Tw T* (\023\024\004\021\017\021\036\035\034\027\t\n \(\022\030\017\021\036\030\017\ \005 \205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\ \021\024\027\026, )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\023\030\026\r\022\024\005 \207\024\027\235\036\030\030\024\027\017\ \) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.178 Tw T* [(\217\036\f\023\024\027\007\036\027\021\t, )0.6(\023\030\036\007\023\024\004\017\021\026\033\013\017\036 )0.5(\r\t\023\024\035\027\016\021\034 )0.6(\021\030\026\027\f\035\033)]TJ 0 Tw (-)Tj -0.023 Tw T* (\n\017\027\026\035\034\027\024\036 \031\001\017\r\026\027\017\036 \200\002\ \217\215\025, \027\036 \024\021\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030)Tj 0 Tw (-)Tj 0.098 Tw T* (\020\017\004\036\f\022\024\n\031 \f\021\026\032\031 \024\021 \030\036\f\023\ \024\027\007\036\027\021\024\r, \027\036 \023\030\026\022\021\017\022\031\ \033\013\017\b )Tj 0 Tw T* (\031\001\017\r\026\027\017\036 \()Tj /T1_1 1 Tf (t )Tj /T1_0 1 Tf (\022\030\017\021\036\030\017\005 \222\021\034\033\007\036\027\021\026, )Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,06\).)Tj /T1_2 1 Tf 0.152 Tw 0 -2.436 TD (\026\002\212\006\002\217 \2364:)Tj /T1_0 1 Tf ( \253\025\026\022\017\n \f\023\024\f\024\002\024\n \200\t \r\t\023\024\035\ \027\016\036\021\036 \007\017\f)Tj 0 Tw (-)Tj 0.057 Tw 0 -1.218 TD [(\021\026\035\034\027\024\036 )0.6(\024\021\n\t\r\026\027\017\036 )0.5(\024\021\022\035\033\004\036\027\027\024\005 )0.6(\004\026\f\021\017 )0.5(\021\024\035\f\021\024\005 )0.6(\022\017\001)]TJ 0 Tw (-)Tj T* (\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\024\n \030\026\027\036\027\017\017\ \023\030\016\n\024\005 \022\017\001\022\017?\273)Tj 0.004 Tc 0.264 Tw T* [(\222\030\036\007\017 \r\f\036\b \030\036\f\023\024\027\007\036\027\021\024\ \r \002\024\035\034\001\026\016 \004\026\f\021\034 \024\021\007\026\r\026\ \035\026)4( )]TJ 0.094 Tw T* [(\023\030\036\007\023\024\004\021\036\027\017\036 \024\021\n\t\r\026\027\017\ \033 \004\036\030\036 \f\021\024\n\031 \024\021\022\035\033\004\036\027\ \027\024\005)4( )]TJ 0.077 Tw T* (\004\026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 47 \(35; 59\) %. \200\t\002\024\030 \n\036\021\024)Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.248 Tw T* [(\007\024\r \024\021\n\t\r\026\027\017\016 \024\021\022\035\033\004\036\027\ \027\024\005 \004\026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\ \017)4( )]TJ 0.23 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \030\ \026\035\017\004\026\035\f\016 \f\030\036\007\017 \017\f\f\035\036\007\031\ )Tj 0 Tc 0 Tw (-)Tj 0.004 Tc 0.542 Tw T* [(\036\n\t\b )0.5(\211\204\215 )0.6(\(\022\030\017\021\036\030\017\005 )0.5(\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026,)4( )]TJ /T1_1 1 Tf 0 Tc 0 Tw T* (p)Tj /T1_0 1 Tf 0.004 Tc /Span<>> BDC 0.482 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,3\26710)Tj -0.004 Tw 5.83 0 0 5.83 342.3966 180.1498 Tm (-4)Tj 10 0 0 10 347.4104 176.8198 Tm (\).)Tj 0 Tc 0.22 Tw -4.41 -1.218 Td (\200 \004\026\f\021\027\024\f\021\017, \027\026)Tj /Span<>> BDC ( )Tj EMC (3 \211\204\215 \f\021\026\021\017\f\021\017\004\036\f\022\017 \030\036\032\ \036 \r\t\023\024\035)Tj 0 Tw (-)Tj 0.182 Tw T* 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\221\026\022\032\036 \f\021\026\021\017\f\021\017\004\036)Tj 0 Tw (-)Tj -0.036 Tw T* (\f\022\017\036 \027\026\004\017\n\t\036 \030\026\035\017\004\017\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \211\204\215 \027\026\002\035\033\007\026\035\017\f\034\ )Tj 0.093 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \r\027\031\021\030\017\023\030\024\f\r\036\021\027\t\ \b \n\036\021\024\007\024\r \007\017\026\020\027\024\f\021\017\022\017 )Tj 0.139 Tw 23.244 3.653 Td (\023\024\r\030\036\032\007\036\027\017\005 \023\030\016\n\024\005 \022\017\ \001\022\017 \(\023\030\024\022\021\024-, \030\036\022\021\024\f\022\024\ \023\017\016\) )Tj -0.001 Tw T* (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_2 1 Tf 0 Tw (\032)Tj /T1_1 1 Tf -0.001 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,014 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.226 Tw T* (\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\226\216\024\ \b\002\036\030\020\026\) \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\002\030\024\022\024\035\024\027\024\f\022\024)Tj 0 Tw (-)Tj 0.097 Tw T* [(\023\017\017 )0.5(\(\022\030\017\021\036\030\017\005 )0.6(\205\017\001\036\030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\ \024\027\026, )]TJ /T1_2 1 Tf 0 Tw 18.288 0 Td (\032)Tj /T1_1 1 Tf 0.097 Tw /Span<>> BDC ( )Tj EMC 0.807 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.829 0 Td (0,005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.047 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \003\025\020\f\022\016 \021\025\r\023\032\027\025\025\027\235 \024\031\b\ \f\020\024\031\021\020\025\025\031\024\023\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\n\031\204\203\203\022\006\022\027\025\023\r \003\2051 \216\021\027\023\020\ \021)Tj /Span<>> BDC ( )Tj EMC (\030\022\020\b\025\031\024\023\022\n\027 \022)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\031\235 \023\020\n\023\022\n\027 \ )Tj 0.039 Tw 0 -1.2 TD (\f\027\007\027\025\022\t \021\025\027\240\032\005\213\022\025\025\013\200\ \032\020\025\027\025\022\235 \033\032\t\026\031\235 \n\022\213\n\022 \026\ \027\255\030\r \b\032\r\033\033\020\026\022 \032\027\024\033\031\025\030\ \027\025\023\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025)Tj 0 Tw (-)Tj T* (\024\n\031\235 \033\031\026\031\212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.002 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.025 Tw 3.293 0 Td [( )0.5(Ana)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 4.625 0 Td [(i)3.9(n)-0.6(t)-1.6(e)-6(r)-18.6(na)-4.4(l c)2.9(o)-4(n)3.7(s)-12.5(i)6.6(s)-14.8(t)-1.6(e)-7(n)-2.9(c)-32.4(y )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 9.059 0 Td [(d)-3(i)1.5(a)-5.2(g)-2.4(n)-2.4(o)-1.1(s)-14.7(t)-29.1(i)-1.8(c)-26.7(s )0.5(a)-5.1(n)-4.8(d )0.5(s)6.7(u)1.6(r)-2(g)-18.7(i)-1.8(c)3.2(a)-4.5(l )0.5(t)-1.9(a)-9.2(c)-32.4(t)-29.1(i)-1.8(c)-26.7(s )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 13.516 0 Td [(t)-9.6(r)-2(e)-7.5(a)-9.2(t)-10.6(m)-5.2(e)-7(n)-0.6(t )0.5(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 5.162 0 Td [(e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.3(e)-6(r)-38.9(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l )0.5(w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.8(s )0.5(o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC 10.492 0 Td [(t)-10.6(h)-2.4(e )0.5(r)-2(e)-10.9(c)-32.4(t)-1.1(u)0.7(m )]TJ 0 Tw -46.146 -1.2 Td [(b)-10.1(e)-8.6(t)-22.9(w)2.2(e)-10.4(e)-6.9(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-1.9(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-7(n)-0.6(t)-32.9(s a)-9.1(t d)-3(i)5.1(f)-42.4(f)-13.4(e)-6(r)-2(e)-6.9(n)-0.6(t le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-3(i)-1.8(c)3.2(a)-4.5(l c)3.3(a)-4.2(r)-2(e w)-26.7(i)-3.4(t)-10.5(h t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(G)2.5(w)2.2(e)-8.6(t)-35.2(\222)25.1(s a)-5.2(g)-1.5(r)-2(e)-10.4(e)-7(m)-5.3(e)-7(n)-0.6(t c)2.8(o)-11.9(ef)-40.6(\243)-1.2(c)-30.1(i)-1.4(e)-7(n)-0.6(t A)10.5(C)18.7(1)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 682.7811 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 292.2185 682.7811 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 348.9114 682.7811 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 405.6044 682.7811 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 462.2972 682.7811 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 652.3619 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 652.1119 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 652.1119 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 652.1119 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 652.1119 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 652.1119 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 631.3005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 631.0505 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 631.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 631.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 631.0505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 631.0505 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 610.2393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 609.9893 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 609.9893 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 609.9893 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 609.9893 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 609.9893 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 589.178 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 588.928 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 588.928 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 588.928 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 588.928 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 588.928 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 577.7167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 577.4667 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 577.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 577.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 577.4667 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 577.4667 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 566.2554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 566.0054 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 566.0054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 566.0054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 566.0054 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 566.0054 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 545.1942 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 544.9442 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 544.9442 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 544.9442 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 544.9442 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 544.9442 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 524.1329 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 523.8829 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 523.8829 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 523.8829 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 523.8829 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 523.8829 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 503.0716 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 502.8216 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 502.8216 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 348.9114 502.8216 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 405.6044 502.8216 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 462.2972 502.8216 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 491.6103 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 491.3603 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 42.7697 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 491.3603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 292.2185 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 348.9114 491.3603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 405.6044 491.3603 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 462.2972 491.3603 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 462.2972 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 470.549 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 470.299 cm 0 0 m 249.699 0 l S Q q 1 0 0 1 292.2185 470.299 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 348.9114 470.299 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 405.6044 470.299 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 462.2972 470.299 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 85.4071 664.5466 Tm (\231\f\r\214\r\b\003 \240\t\004\n\b\002\217\003\t\220\t \t)Tj /Span<>> BDC ( )Tj EMC (\216\t\006\210\006\n\t\201\r\217\220\002\005 \003\004\220\003\t\220\t)Tj 26.873 1.2 Td (\021\002\f\t\201\r\217\003\002 )Tj -0.52 -1.2 Td (\006\r\217\212\002\b\240\r\b\003\002 )Tj 0.749 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\013\206\002\006\220\r)Tj 6.348 1.8 Td (\021\002\234\226\226\t\204\t\r\b\003 )Tj /T1_4 1 Tf 2.23 -1.2 Td (\026\0301)Tj /T1_3 1 Tf 5.276 1.2 Td (95% \031\034 \240\f\235 )Tj /T1_4 1 Tf 1.81 -1.2 Td (AC1)Tj 6.212 0.601 Td (\t)Tj /T1_1 1 Tf -53.953 -2.633 Td (\222\023\024\f\024\002 \235\024\030\n\017\030\024\r\026\027\017\016 \007\ \017\r\036\030\f\017\024\027\027\024\005 \022\024\035\024\f\021\024\n\t \ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b )Tj T* (\200\002\217\215\025)Tj 33.87 1.2 Td (75)Tj 6.244 0 Td (\2440,069)Tj 5.602 0 Td (\(\2440,17; 0,031\))Tj 7.654 0 Td (0,91)Tj -53.37 -2.633 Td (\215\030\017\n\036\027\036\027\017\036 \021\030\026\027\f\035\033\n\017\027\ \026\035\034\027\024\020\024 \031\001\017\r\026\027\017\016 \007\036\235\ \036\022\021\026 \023\030\016\n\024\005 \022\017\001\022\017 )Tj T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\036\007\036\f\021\030\031\022\021\017\r\027\t\b \200\002\217\215\025\ )Tj 33.87 1.2 Td (75)Tj 6.244 0 Td (\2440,074)Tj 5.852 0 Td (\(\2440,32; 0,17\))Tj 7.404 0 Td (0,73)Tj -53.37 -2.633 Td (\222\023\024\f\024\002 \007\017\f\021\026\035\034\027\024\020\024 \024\021\ \n\t\r\026\027\017\016 \024\021\022\035\033\004\036\027\027\024\005 \004\ \026\f\021\017 \021\024\035\f\021\024\005 \022\017\001\022\017 )Tj 0 -1.2 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (75)Tj 6.494 0 Td (0,044)Tj 5.602 0 Td (\(\2440,07; 0,56\))Tj 7.404 0 Td (0,21)Tj -53.37 -2.633 Td (\200\t\023\024\035\027\036\027\017\036 \007\017\r\031\035\034\f\017\017 \ \f\235\017\027\022\021\036\030\026 \023\030\016\n\024\005 \022\017\001\022\ \017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 0 Td (75)Tj 6.744 0 Td (0,17)Tj 5.352 0 Td (\(\2440,14; 0,48\))Tj 7.404 0 Td (0,13)Tj -53.37 -1.433 Td (\210\f\027\024\r\027\024\005 \023\030\017\n\036\027\016\036\n\t\005 \n\036\ \021\024\007 \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\ \025)Tj 33.87 0 Td (75)Tj 6.494 0 Td (0,081)Tj 5.602 0 Td (\(\2440,01; 0,18\))Tj 7.404 0 Td (0,04)Tj -53.37 -1.433 Td (\206\035\031\002\017\027\026 \031\f\021\026\027\024\r\022\017 \023\026\030\ \026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\027\026\032\ \026 \023\030\024\n\036\032\027\024\f\021\027\t\n \007\024\f\021\031\023\ \024\n )Tj T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (48)Tj 6.494 0 Td (0,082)Tj 5.602 0 Td (\(\2440,01; 0,17\))Tj 6.904 0 Td (0,0037)Tj -52.87 -2.633 Td (\210\030\017\036\027\021\017\030 \007\035\016 \022\024\027\021\030\024\035\ \016 \020\035\031\002\017\027\t \031\f\021\026\027\024\r\022\017 \023\026\ \030\026\030\036\022\021\026\035\034\027\024\020\024 \007\030\036\027\026\ \032\026 )Tj T* (\023\030\024\n\036\032\027\024\f\021\027\t\n \007\024\f\021\031\023\024\n\ \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (42)Tj 6.744 0 Td (0,16)Tj 5.352 0 Td (\(0,072; 0,24\))Tj 6.785 0 Td (3,9\26710)Tj /Span<>> BDC 4.664 0 0 4.664 487.0183 538.9816 Tm (-)Tj EMC (4)Tj 8 0 0 8 45.6044 515.2563 Tm (\211\f\021\026\027\024\r\022\026 \023\026\030\026\030\036\022\021\026\035\ \034\027\t\b \007\030\036\027\026\032\036\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\017\035\017 \023\024\f\035\036 \031\001\017\r\026\027\017\016 )Tj 0 -1.2 TD (\035\026\023\026\030\024\021\024\n\027\024\005 \030\026\027\t \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (67)Tj 6.744 0 Td (0,38)Tj 5.602 0 Td (\(0,12; 0,65\))Tj 6.654 0 Td (0,0032)Tj -52.87 -2.633 Td (\037\036\035\034 \030\031\021\017\027\027\024\020\024 \023\026\030\026\030\ \036\022\021\026\035\034\027\024\020\024 \007\030\036\027\017\030\024\r\026\ \027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 0 Td (75)Tj 6.744 0 Td (0,45)Tj 5.602 0 Td (\(0,22; 0,63\))Tj 6.535 0 Td (1,4\26710)Tj /Span<>> BDC 4.664 0 0 4.664 487.0183 496.859 Tm (-)Tj EMC (4)Tj 8 0 0 8 45.6044 482.7337 Tm (\222\023\024\f\024\002 \007\030\036\027\017\030\024\r\026\027\017\016 \022\ \035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\f\ \021\r \021\026\026 \023\030\024\n\036\032\027\024\f\021\027\t\n )Tj T* (\007\024\f\021\031\023\024\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025)Tj 33.87 1.2 Td (75)Tj 6.744 0 Td (0,46)Tj 5.602 0 Td (\(0,23; 0,69\))Tj 6.535 0 Td (2,3\26710)Tj /Span<>> BDC 4.664 0 0 4.664 487.0183 485.3977 Tm (-)Tj EMC (4)Tj /T1_2 1 Tf 7 0 0 7 42.5197 458.8144 Tm [(\004\032\022\026\027\007\020\025\022\027: \021\027\032\240\020\f\017\025\ \020\t \213\n\020\f\020 \030\f\t \n\031\204\203\203\022\006\022\027\025\023\ \020 \024\031\b)28.5(\f\020\024\031\021\020\025\025\031\024\023\022 \003)48.1(\2051 \(Gw)12(et K., 2014\): 0,0\2310,4)]TJ /Span<>> BDC ( )Tj EMC (\227 \025\022\016\n\020\t \024\023\027\033\027\025\017; 0,4\2310,8)Tj /Span<>> BDC ( )Tj EMC (\227 \024\032\027\030\025\t\t \024\023\027\033\027\025\017; 0,8\2311,0)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj T* (\021\013\024\031\n\020\t \024\023\027\033\027\025\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.01 Tc 9 0 0 9 42.5197 431.1105 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\032\022\026\027\025\027\025\022\027 \032\027\024\033\031\025\030\027\ \025\023\020\026\022 \026\027\023\031\030\031\021 \030\022\020\b\025\031\ \024\023\022\n\022 \211\240\206\004\202 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\ \212\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( R)2.8(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.2(e)-7(n)-0.6(t)-32.9(s u)-4.4(s)0.5(e o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-3(i)1.5(a)-5.2(g)-2.4(n)-2.4(o)-1.1(s)-14.8(t)-29.1(i)-1.8(c m)-5.2(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.8(s f)-13.3(o)-3(r e)-32.4(x)-32.5(t)-9.6(r)3.3(a)-5.2(p)-11.3(e)-5.9(r)-39(i)-3.4(t)-3(o)-4(n)-2.4(e)-7.5(a)-4.5(l r)-2(e)-10.8(c)-32.4(t)-2(a)-4.5(l w)2.2(o)-3.4(u)0.6(n)-4.8(d)-5.7(s a)-9.2(t v)6.3(a)-4.2(r)-39(i)-1.4(o)-3.3(u)-4.4(s le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-3(i)-1.8(c)3.2(a)-4.5(l c)3.2(a)-4.2(r)-2(e)]TJ ET /GS2 gs q 1 0 0 1 42.5197 415.8085 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 415.8085 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 215.6831 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 261.0374 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 306.3918 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 415.8085 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 415.8085 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9587 415.8085 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 404.5893 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 404.3393 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 158.9902 404.3393 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 215.6831 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 261.0374 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 306.3918 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 404.3393 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 404.3393 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 450.9587 404.3393 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 393.1201 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 392.8701 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 381.4088 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 392.8701 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 392.8701 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 392.8701 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 392.8701 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 381.6588 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 352.8588 cm 0 0 m 0 28.55 l S Q q 1 0 0 1 158.7402 381.4088 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 215.6831 381.4088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 261.0374 381.4088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 306.3918 381.4088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 351.7461 381.4088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 397.1004 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 450.7087 381.4088 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 496.313 352.8588 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 42.5197 352.6088 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 341.1475 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 352.6088 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 352.6088 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 352.6088 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 352.6088 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 341.3975 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 329.9362 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 341.1475 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 341.1475 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 341.1475 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 341.1475 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 341.1475 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 341.1475 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 329.9362 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 329.6862 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 318.2249 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 329.6862 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 329.6862 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 329.6862 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 329.6862 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 318.4749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 307.0136 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 318.2249 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 318.2249 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 318.2249 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 318.2249 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 318.2249 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 318.2249 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 307.0136 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 306.7636 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 295.3024 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 306.7636 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 306.7636 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 306.7636 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 306.7636 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 295.5524 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 266.7524 cm 0 0 m 0 28.55 l S Q q 1 0 0 1 158.7402 295.3024 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 215.6831 295.3024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 261.0374 295.3024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 306.3918 295.3024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 351.7461 295.3024 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 397.1004 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 450.7087 295.3024 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 496.313 266.7524 cm 0 0 m 0 28.3 l S Q q 1 0 0 1 42.5197 266.5024 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 255.0411 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 266.5024 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 266.5024 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 266.5024 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 266.5024 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 255.2911 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 243.8298 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 255.0411 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 255.0411 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 255.0411 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 255.0411 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 255.0411 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 255.0411 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 243.8298 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 243.5798 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 232.1185 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 243.5798 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 243.5798 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 243.5798 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 243.5798 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 232.3685 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 213.1685 cm 0 0 m 0 18.95 l S Q q 1 0 0 1 158.7402 232.1185 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 215.6831 232.1185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 261.0374 232.1185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 306.3918 232.1185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 351.7461 232.1185 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 397.1004 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 450.7087 232.1185 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 496.313 213.1685 cm 0 0 m 0 18.7 l S Q q 1 0 0 1 42.5197 212.9185 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 201.4572 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.9902 212.9185 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 212.9185 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 212.9185 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 212.9185 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 201.7072 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.7697 190.2459 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 158.7402 201.4572 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 158.9902 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 201.4572 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 201.4572 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 306.3918 201.4572 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 201.4572 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 351.7461 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 397.1004 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.7087 201.4572 cm 0 0 m 45.854 0 l S Q q 1 0 0 1 450.9587 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 190.2459 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 189.9959 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 158.9902 189.9959 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 215.6831 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 261.0374 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 189.9959 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 397.1004 189.9959 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 450.9587 189.9959 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 178.7847 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 178.5347 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 42.7697 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 158.9902 178.5347 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 158.9902 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 215.6831 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 215.6831 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 261.0374 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 178.5347 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 397.1004 178.5347 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 397.1004 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 450.9587 178.5347 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 450.9587 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 157.7234 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 157.4734 cm 0 0 m 116.47 0 l S Q q 1 0 0 1 158.9902 157.4734 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 215.6831 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 261.0374 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 306.3918 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 351.7461 157.4734 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 397.1004 157.4734 cm 0 0 m 53.858 0 l S Q q 1 0 0 1 450.9587 157.4734 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 67.3123 407.174 Tm (\215\r\003\002\240 \240\t\004\n\b\002\217\003\t\220\t)Tj 13.024 0 Td (\255\t\214\002\f\013)Tj 6.168 0 Td (2 \210\006\002\r\b\001)Tj 5.669 0 Td (3 \210\006\002\r\b\001)Tj 5.669 0 Td (4 \210\006\002\r\b\001)Tj 5.669 0 Td (5 \210\006\002\r\b\001)Tj /T1_4 1 Tf 8.13 0.001 Td (\t)Tj /T1_3 1 Tf 5.017 -0.001 Td (\017\206\227\r\r)Tj /T1_1 1 Tf -52.061 -1.433 Td (\210\002\255\036\n \r\t\002\024\030\022\017)Tj /T1_4 1 Tf 17.404 0 Td (N)Tj /T1_3 1 Tf 6.134 -0.001 Td (24)Tj 5.669 0 Td (20)Tj 5.669 0 Td (22)Tj 5.947 0 Td (9)Tj /T1_4 1 Tf 6.201 0.001 Td (\226)Tj /T1_3 1 Tf 5.923 -0.001 Td (75)Tj /T1_1 1 Tf -52.948 -1.433 Td (\215\026\035\034\006\036\r\024\036 \030\036\022\021\026\035\034\027\024\036\ )Tj T* (\017\f\f\035\036\007\024\r\026\027\017\036)Tj /T1_2 1 Tf 17.467 1.2 Td (n)Tj /T1_1 1 Tf 6.128 0 Td (18)Tj 5.919 0 Td (8)Tj 5.669 0 Td (1)Tj 5.669 0 Td (0)Tj 5.452 0 Td (10)Tj 4.664 0 0 4.664 424.0427 386.9075 Tm (-6)Tj 8 0 0 8 428.0164 384.2435 Tm (*)Tj /T1_2 1 Tf -2.422 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 412.4622 377.3075 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 418.7679 374.6435 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 434.4957 377.3075 Tm (\2265)Tj /T1_2 1 Tf 8 0 0 8 408.6382 365.0435 Tm (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 412.4622 367.7075 Tm (2-5)Tj /Span<>> BDC 8 0 0 8 418.7679 365.0435 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 4.664 0 0 4.664 434.4957 367.7075 Tm (\2263)Tj /T1_2 1 Tf 8 0 0 8 406.7495 355.4435 Tm (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.5734 358.1075 Tm (3-4)Tj /Span<>> BDC ( )Tj EMC 8 0 0 8 417.9658 355.4435 Tm (=)Tj /Span<>> BDC ( )Tj EMC (0,031)Tj 6.459 3.6 Td (27)Tj /T1_2 1 Tf -38.369 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.201 0 Td (78)Tj /Span<>> BDC ( )Tj EMC (\(50; 95\))Tj 5.669 0 Td (40)Tj /Span<>> BDC ( )Tj EMC (\(15; 69\))Tj 6.169 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 29\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 11.902 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(25; 48\))Tj -51.245 -3.6 Td (\217\036\027\021\020\036\027\024\020\030\026\235\017\016)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (3)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.358 0 Td (0,15*)Tj 7.043 0 Td (3)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.201 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(17; 40\))Tj 6.169 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 22\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 12.059 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0,8; 11\))Tj -51.403 -1.433 Td (\215\030\024\022\021\024-, \030\036\022\021\024\f\022\024\023\017\016, \024\ \f\n\024\021\030 )Tj T* (\r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026\035\026\b)Tj /T1_2 1 Tf 17.467 1.2 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (1)Tj 5.669 0 Td (0)Tj 5.669 0 Td (5)Tj 5.669 0 Td (3)Tj 5.108 0 Td (0,014*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 314.1236 Tm (3-5)Tj /Span<>> BDC 8 0 0 8 416.4905 311.4596 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,038)Tj 6.893 1.2 Td (9)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 28\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.419 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(6; 53\))Tj 5.669 0 Td (33)Tj /Span<>> BDC ( )Tj EMC (\(5; 77\))Tj 12.402 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(5; 22\))Tj -51.495 -1.433 Td (\025\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\026\ \235\017\016)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (1)Tj 5.419 0 Td (11)Tj 5.669 0 Td (10)Tj 5.919 0 Td (5)Tj 5.108 0 Td (0,001*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 291.201 Tm (2-3)Tj /Span<>> BDC 8 0 0 8 416.4905 288.537 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 281.601 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 416.4905 278.937 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,006)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 272.001 Tm (2-5)Tj /Span<>> BDC 8 0 0 8 416.4905 269.337 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004)Tj 6.643 3.6 Td (27)Tj /T1_2 1 Tf -38.369 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.818 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0;28\))Tj 5.053 0 Td (55)Tj /Span<>> BDC ( )Tj EMC (\(25; 81\))Tj 5.669 0 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(20; 73\))Tj 5.669 0 Td (56)Tj /Span<>> BDC ( )Tj EMC (\(16; 90\))Tj 12.402 0 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(25; 48\))Tj -51.245 -3.6 Td (FAST-\023\030\024\021\024\022\024\035)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (1)Tj 5.669 0 Td (1)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.358 0 Td (0,81*)Tj /T1_2 1 Tf -1.116 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 250.9398 Tm (3-5)Tj /Span<>> BDC 8 0 0 8 416.4905 248.2758 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,038)Tj 6.893 1.2 Td (2)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(0; 28\))Tj 5.669 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(0; 32\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 22\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 12.309 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(0,3; 9\))Tj -51.653 -1.433 Td (\205\017\002\030\024\022\024\035\024\027\024\f\022\024\023\017\016)Tj /T1_2 1 Tf 17.467 0 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (6)Tj 5.669 0 Td (0)Tj 5.108 0 Td (0,005*)Tj /T1_2 1 Tf -0.866 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 228.0172 Tm (2-4)Tj /Span<>> BDC 8 0 0 8 416.4905 225.3532 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,018)Tj /T1_2 1 Tf -1.266 -1.2 Td (\032)Tj /T1_1 1 Tf 4.664 0 0 4.664 410.1848 218.4172 Tm (3-4)Tj /Span<>> BDC 8 0 0 8 416.4905 215.7532 Tm ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,035)Tj 6.893 2.4 Td (6)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.419 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(8; 58\))Tj 5.919 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 43\))Tj 12.402 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(2; 17\))Tj -51.745 -2.4 Td (\204\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ )Tj T* (\021\024\n\024\020\030\026\235\017\016)Tj /T1_2 1 Tf 17.467 1.2 Td (n)Tj /T1_1 1 Tf 6.378 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (0)Tj 5.669 0 Td (1)Tj 5.358 0 Td (0,15*)Tj 7.043 0 Td (1)Tj /T1_2 1 Tf -38.619 -1.433 Td (f)Tj /T1_1 1 Tf ( \(%\) \f 95% \212\230)Tj 7.701 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 21\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 23\))Tj 5.669 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0; 22\))Tj 5.419 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(0; 57\))Tj 12.902 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(0; 7\))Tj /T1_2 1 Tf -51.995 -1.433 Td (p)Tj /T1_1 1 Tf (-\027\026\004\036\027\017\036)Tj /T1_2 1 Tf 17.478 0 Td (p)Tj /T1_1 1 Tf 13.179 0 Td (1,6 \b 10)Tj 4.664 0 0 4.664 315.6187 184.0333 Tm (-10)Tj 8 0 0 8 421.8055 181.3693 Tm (\226)Tj 6.201 0 Td (\226)Tj -53.226 -1.433 Td (\025\024\220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\ \027\024\f\021\017 )Tj /T1_2 1 Tf (V)Tj /T1_1 1 Tf ( )Tj T* (\025\030\026\n\036\030\026 \(95% \212\230\))Tj /T1_2 1 Tf 17.477 1.2 Td (V)Tj /T1_1 1 Tf 11.835 0 Td (0,55)Tj /Span<>> BDC ( )Tj EMC (\(0,37; 0,69\))Tj 17.713 0 Td (\226)Tj 6.201 0 Td (\226)Tj /T1_2 1 Tf 7 0 0 7 42.5197 145.9888 Tm (\004\032\022\026\027\007\020\025\022\027: n)Tj /Span<>> BDC ( )Tj EMC (\227 \007\022\024\f\027\025\025\031\024\023\017; f)Tj /Span<>> BDC ( )Tj EMC (\227 \030\031\f\t \(\031\023\025\031\024\022\023\027\f\017\025\020\t \007\ \020\024\023\031\023\020\). \211)Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013)0.8( \b\032\020\025\022\006\013 \023\031\007\025\013\200 95%-\200 \220\002 \030\ \f\t \033\020\032\020\026\027\023\032\031\021 \033\031\f\022\025\031\026\ \022\020\f\017\025\031\b\031 )]TJ 0 -1.2 TD (\032\020\024\033\032\027\030\027\f\027\025\022\t; p*)Tj /Span<>> BDC ( )Tj EMC (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\027\025\030\255\020\026\022\025\022\231\225\031\200\240\ \027\032\b\020; \032)Tj 4.081 0 0 4.081 303.4887 139.9198 Tm (n1-n2)Tj /Span<>> BDC ( )Tj EMC 7 0 0 7 313.8094 137.5888 Tm (\227 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\033\032\020\021\n\031\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\255\027\024\023\021\027\025\025\013\027 \024\032\020\021\025\ \027\025\022\t \221\031\025\203\027\032\032\031\025\022.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 505.4397 56.0378 Tm (105)Tj ET endstream endobj 962 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.134 Tw 10 0 0 10 70.8661 603.0499 Tm (\212\035\016 \n\036\030\027\t\b \007\026\027\027\t\b \030\026\f\f\004\017\ \021\t\r\026\035\017 95% \007\024\r\036\030\017\021\036\035\034)Tj 0 Tw (-)Tj 0.366 Tw 0 -1.218 TD (\027\t\036 \017\027\021\036\030\r\026\035\t \(\212\230\) \027\036\023\026\ \030\026\n\036\021\030\017\004\036\f\022\017\n \n\036\021\024\007\024\n \ )Tj 0.348 Tw T* (\030\036\f\026\n\023\035\017\027\020\026 \(\002\031\021\f\021\030\036\023\ \). \221\024\004\027\t\036 95% \007\024\r\036\030\017\021\036\035\034)Tj 0 Tw (-)Tj 0.135 Tw 0 -1.218 TD (\027\t\036 \017\027\021\036\030\r\026\035\t \007\035\016 \r\t\002\024\030\ \024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\002\017\027\024\n\017\027\026\035\034\027\t\n \030\026\f)Tj 0 Tw (-)Tj 0.375 Tw 0 -1.218 TD (\023\030\036\007\036\035\036\027\017\036\n \r\036\030\024\016\021\027\024\ \f\021\036\005 \030\026\f\f\004\017\021\t\r\026\035\017 \n\036\021\024\007\ \024\n )Tj 0.075 Tw 0 -1.218 TD (\025\035\024\023\023\036\030\026\226\215\017\030\f\024\027\026. \212\035\ \016 \023\030\024\r\036\030\022\017 \020\017\023\024\021\036 \023\030\017\ \n\036\027\016)Tj 0 Tw (-)Tj 0.138 Tw 0 -1.218 TD [(\035\017 \030\026\027\007\024\n\017\026\006\017\024\027\027\t\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\023\036\030\036\f\021\026\027\024\r\024\004\027\t\036 \023\030\024\006\036\ \007\031)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\t \204\024\027\021\036-\025\026\030\035\024.)Tj 0.336 Tw 0 -1.218 TD (\212\035\016 \026\027\026\035\017\026 \021\026\002\035\017\006 \f\024\023\ \030\016\032\036\027\027\024\f\021\017 \017\f\023\024\035\034\024\r\026\ \035\017 )Tj 0.214 Tw 0 -1.218 TD (\021\024\004\027\t\005 \022\030\017\021\036\030\017\005 \205\017\001\036\ \030\026\226\205\030\017\n\036\027\026\226\216\024\035\021\024\027\026. \ \200)Tj /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tw (-)Tj 0.244 Tw T* (\004\036\f\021\r\036 \n\036\030\t \f\r\016\017 \017\035\017 \027\036\024\ \007\027\024\030\024\007\027\024\f\021\017 \r)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \017\f)Tj 0 Tw (-)Tj 0.018 Tw 0 -1.218 TD [(\023\024\035\034\024\r\026\035\017 \022\024\220\235\235\017\006\017\036\ \027\021 )0.5(\f\024\023\030\016\032\036\027\027\024\f\021\017 )]TJ /T1_1 1 Tf 0 Tw 17.558 0 Td (V)Tj /T1_0 1 Tf 0.018 Tw ( \025\030\026\n\036\030\026. )Tj -0.014 Tw -17.558 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036 \n\036\030\t \f\024\020\035\026\f\017\016 \n\ \036\032\007\031 \007\r\031\n\016 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \024\006\036\027)Tj 0 Tw (-)Tj 0.475 Tw 0 -1.218 TD (\013\017\022\026\n\017 \017\f\023\024\035\034\024\r\026\035\017 \022\024\ \220\235\235\017\006\017\036\027\021 \f\024\023\030\016\032\036\027\027\024\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\f\021\017 )Tj /T1_1 1 Tf 1.73 0 Td (\003\2051 )Tj /T1_0 1 Tf 0.162 Tw 1.868 0 Td [(\206\r\036\021\026, \r\t\004\017\f\035\016\036\n\t\005 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 )0.5(\023\030\024\020\030\026\n\n\t )]TJ 0.383 Tw -3.597 -1.218 Td [(A)-25(gr)-24(eeS)15.1(t)15(a)15(t \(ht)-30(tps://a)-17(gr)-24(eest)15(a)15(t360.com/; 06.08.2025\). )]TJ 0.369 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \007\024\035\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\026\b \f\024\023\030\016\032\036\027\027\024\f\021\ \017 )Tj 0.102 Tw 0 -1.218 TD [(\023\030\017\n\036\027\016\035\017 \023\024\023\030\026\r\022\031 )0.5(\007\035\016 \n\027\024\032\036\f\021\r\036\027\027\t\b \f\030\026\r\027\ \036\027\017\005 )]TJ 0.128 Tw 0 -1.218 TD [(\207\024\027\235\036\030\030\024\027\017 )0.6(\(\023\030\017 )0.5(\023\024\023\026\030\027\024\n )0.6(\f\030\026\r\027\036\027\017\017\) )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 18.263 0 Td (\023\024\023\030\026\r\022\031 )Tj 0.386 Tw -18.263 -1.218 Td [(\207\036\027\007\032\026\n\017\027\017\226\216\024\b\002\036\030\020\026\ )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \020\030\031\023\023. \212\035\016 )Tj 0.181 Tw 0 -1.218 TD (\023\030\024\r\036\030\022\017 \024\007\027\024\030\024\007\027\024\f\021\ \017 \n\036\030\027\t\b \007\026\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\022\024\035\034)Tj 0 Tw (-)Tj 0.042 Tw 0 -1.218 TD [(\022\017\b \r\t\002\024\030\022\026\b \017\f\023\024\035\034\024\r\026\035\ \017 )0.5(\024\007\027\024\235\026\022\021\024\030\027\t\005 )0.5(\007\017\f\023\036\030)]TJ 0 Tw (-)Tj 0 -1.218 TD (\f\017\024\027\027\t\005 \026\027\026\035\017.)Tj 0.083 Tw 0 -1.218 TD [(\212\035\016 \f\030\026\r\027\036\027\017\016 )0.5(\007\r\031\b )0.5(\027\036\026\r\017\f\017\n\t\b )0.5(\r\t\002\024\030\024\022 \f)]TJ /Span<>> BDC ( )Tj EMC (\n\036\030\027\t)Tj 0 Tw (-)Tj 0.097 Tw 0 -1.218 TD (\n\017 \007\026\027\027\t\n\017 \023\030\017\n\036\027\016\035\017 \002\031\ \021\f\021\030\036\023 \030\036\026\035\017\026\006\017\033 t \022\030\017\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\021\036\030\017\016 \222\021\034\033\007\036\027\021\026.)Tj 0.521 Tw 0 -1.218 TD [(\212\035\016 \002\017\027\024\n\017\026\035\034\027\t\b )0.5(\017\f\b\024\007\024\r \r\t\004\017\f\035\016\035\017 \253\001\026\027\f\ \t\273 )]TJ /T1_1 1 Tf 0 Tw 0 -1.218 TD (f)Tj /T1_0 1 Tf 0.095 Tw (/\(1)Tj /Span<>> BDC ( )Tj EMC (\244)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tw (f)Tj /T1_0 1 Tf 0.095 Tw (\) \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\036\021\024\n \002\036\005\024\r\f\022\017\b \026\f\035\ \031\032\017\r\026\033\013\017\b \007\024)Tj 0 Tw (-)Tj -0.028 Tw 0 -1.218 TD (\r\036\030\017\016 \017\027\021\036\030\r\026\035\024\r \(\003\212\230\)\ \f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \023\030\024\020\030\026\n\n\t L)35(eP)25.1(A)16(C )]TJ 0 Tw 0 -1.218 TD [(\(ht)-30(tps://er)-36.9(is62.eu/Er)-36.9(isL)35(eP)25(A)16(C.html/; 06.08.2025\))]TJ -0.002 Tc 0.387 Tw 0 -1.218 TD (\212\035\016 \023\030\024\r\036\030\022\017 \f\024\020\035\026\f\017\016\ \023\024\035\017\027\024\n\017\026\035\034\027\024\020\024 \030\026\f\023\ \030\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.605 Tw 0 -1.218 TD (\007\036\035\036\027\017\016 \030\036\f\023\024\027\007\036\027\021\024\r\ \027\026)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\031\036\n\t\b \031\030\024\r\027\016\b)-2( )]TJ 0.296 Tw 0 -1.218 TD (\030\026\r\027\024\n\036\030\027\024\n\031 \030\026\f\023\030\036\007\036\ \035\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC [(\024\032\017\007\026\036\n\024\005 \007\024\035\036\005)-2( )]TJ 0.201 Tw 0 -1.218 TD (25% \023\030\017\n\036\027\016\035\017 \022\030\017\021\036\030\017\005 \ \f\024\020\035\026\f\017\016 )Tj /T1_1 1 Tf 0 Tc 0 Tw (\250)Tj 5.83 0 0 5.83 231.3884 204.5058 Tm (2)Tj /T1_0 1 Tf -0.002 Tc 0.201 Tw 10 0 0 10 234.2917 201.1758 Tm ( \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\024\020\030\026\n\n\036)-2( )]TJ -0.054 Tw -16.343 -1.218 Td [(L)-32(ang)17(test \(ht)-30(tps://l)-16(ang)17(test.jp/shiny/chi/; 06.08.2025\).)-2( )]TJ 0.794 Tw T* [(\233\235\235\036\022\021\t \023\030\017\027\026\r\026\035\017 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\017)-2( )]TJ 0.002 Tw 0 -1.218 TD (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_1 1 Tf 0 Tc 0 Tw 1.714 0 Td (p)Tj /T1_0 1 Tf -0.002 Tc -0.032 Tw /Span<>> BDC 0.476 0 Td ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05. \212\035\016 \020\030\026\235\017\004\036\f\022\024\005 \030\036\026\ \035\017\026\006\017\017 \007\026\027\027\t\b \017\f)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -2.19 -1.218 Td [(\023\024\035\034\024\r\026\035\026\f\034 \023\030\024\020\030\026\n\n\026\ P)40.1(ast \(\r\036\030\f\017\016 5.2.2\).)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 115.9298 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc -0.058 Tw 10 0 0 10 70.8661 91.5738 Tm (\206\030\031\023\023\t \030\036\f\023\024\027\007\036\027\021\024\r \027\ \036 \030\026\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\032\031 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.071 Tw 0 -1.218 TD [(\020\017\004\036\f\022\024\005 )0.5(\023\030\026\022\021\017\022\017 )0.5(\(\024\007\027\024\235\026\022\021\024\030\027\t\005 )]TJ /T1_1 1 Tf -0.053 Tc 0.053 Tw 15.449 0 Td [(AN)-33(O)-37(V)-11(A)]TJ /T1_0 1 Tf 0 Tc 0 Tw 2.533 0 Td (, )Tj /T1_1 1 Tf 0.489 0 Td (p)Tj /T1_0 1 Tf 0.071 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 1.585 0 Td (0,13\) )Tj 0.245 Tw 3.189 52.365 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\035\017 \024\007\027\024\030\024\007\027\031\033 \007\017\f\023\ \036\030\f\017\033 \(\021\036\f\021 \214\036\r\017\027\026 \007\035\016 \ )Tj 0.124 Tw T* [(\f\030\036\007\027\017\b )0.5(\027\026\004\036\027\017\005, )]TJ /T1_1 1 Tf 0 Tw 8.157 0 Td (p)Tj /T1_0 1 Tf 0.124 Tw /Span<>> BDC ( )Tj EMC 0.834 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.857 0 Td [(0,93\). )0.5(\222\030\036\007\027\036\036 )0.5(\027\026\004\036\027\017\036 )0.6(\f\021\026)]TJ 0 Tw (-)Tj 0.081 Tw -9.848 -1.218 Td (\032\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b \211\204\215 \f\024\f\021\026\r\017\035\024 15 \(13; 16\) \035\ \036\021 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\). )Tj 0.129 Tw 0 -1.218 TD (\204\017\027\017\n\026\035\034\027\t\005 \b\017\030\031\030\020\017\004\036\ \f\022\017\005 \f\021\026\032 \030\036\f\023\024\027\007\036\027\021\024\ \r)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj -0.002 Tw 0 -1.218 TD (1)Tj /Span<>> BDC ( )Tj EMC (\020\024\007, \026)Tj /Span<>> BDC ( )Tj EMC (\n\026\022\f\017\n\026\035\034\027\t\005)Tj /Span<>> BDC ( )Tj EMC [(\227 25 \035\036\021. \230\b )0.5(\007\024\035\017 \f\021\026\021\017\f\021\017\004\036)]TJ 0 Tw (-)Tj 0.012 Tw T* (\f\022\017 \027\026\004\017\n\024 \027\036 \024\021\035\017\004\026\035\ \017\f\034 \024\021 \030\026\r\027\024\n\036\030\027\024\020\024 \023\024\ \035\017\027\024)Tj 0 Tw (-)Tj T* (\n\017\026\035\034\027\024\020\024 \(\022\030\017\021\036\030\017\005 \f\ \024\020\035\026\f\024\r\026\027\027\024\f\021\017 \245)Tj 5.83 0 0 5.83 471.3848 533.3118 Tm (2)Tj 10 0 0 10 474.2997 529.9818 Tm (, )Tj /T1_1 1 Tf (\032)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,066\).)Tj 0.106 Tw -17.099 -1.218 Td [(\210\023\030\024\f \b\017\030\031\030\020\024\r )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 8.241 0 Td [(\017\f\f\035\036\007\031\036\n\t\b )0.5(\211\204\215 \r\t\016\r\017\035 )0.5(\030\026\f\f\024)]TJ 0 Tw (-)Tj 0.111 Tw -8.241 -1.218 Td (\020\035\026\f\024\r\026\027\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \024\021\r\036\021\024\r \030\036\ \f\023\024\027\007\036\027\021\024\r )Tj 0.126 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\031 \007\017\026\020\027\024\f\021\017\004\036\f\022\017\ \b \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\t\b \n\036\021\024\007\024\r )Tj 0.034 Tw T* (\035\036\004\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\200\002\217\215\025 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\n \233\204\233. \222\030\036\007\027\016\016 \f\021\ \036\023\036\027\034 )Tj 0.156 Tw T* [(\f\024\020\035\026\f\024\r\026\027\027\024\f\021\017 )0.6(\007\024\f\021\017\020\027\031\021\026 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 14.161 0 Td [(\024\021\r\036\021\036 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 4.419 0 Td (\r\024\023\030\024\f\t )Tj -0.014 Tw -18.58 -1.218 Td (\024)Tj /Span<>> BDC ( )Tj EMC (\f\023\024\f\024\002\036 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\016\b \r\t\023\024\035\027\036\027\017\016 \030\031\021\017\ \027\027\024\020\024 \007\030\036\027\017\030\024\r\026)Tj 0 Tw (-)Tj 0.039 Tw T* (\027\017\016 \022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\ \021\030\026\027\f\021\r \021\026\026. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\r\036\021\026\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024)Tj 0 Tw (-)Tj -0.026 Tw T* (\023\030\024\f \024)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024\f\021\017 \r\t\023\ \024\035\027\036\027\017\016 \024\023\036\030\026\021\017\r\027\t\b )Tj 0.289 Tw T* (\023\030\017\036\n\024\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\021\030\026\023\036\030\017\021\024\027\036\026\035\034\027\t\ \b \023\024\r\030\036\032\007\036\027\017\016\b )Tj 0.115 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \022\024\220\235\235\017\006\ \017\036\027\021 )Tj /T1_1 1 Tf 0 Tw (\003\2051 )Tj /T1_0 1 Tf 0.115 Tw 14.195 0 Td (\206\r\036\021\026 \023\030\017\002\035\017\017\035\f\016 )Tj 0.091 Tw -14.195 -1.218 Td (\022)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \f\021\036\023\036\027\017 \f\024\020\035\026\ \f\024\r\026\027\027\024\f\021\017)Tj /Span<>> BDC ( )Tj EMC (\227 0,383 \(0,119; )Tj 0 Tw T* (0,647\) \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.211 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \024\021\f\031\021\f\021\r\017\ \036 \017\035\017 \027\017\022\026\016 \f\024\020\035\026\f\024\r\026\027\ )Tj 0 Tw (-)Tj 0.012 Tw T* (\027\024\f\021\034 \007\035\016 \002\024\035\034\001\017\027\f\021\r\026\ \024\021\r\036\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\024\023\030\024\f\t \024)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\021\017\022\036 )Tj 0.283 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \200\002\217\215\025 \b\017\030\031\030\020\026\n\017-\030\036\f\ \023\024\027)Tj 0 Tw (-)Tj -0.091 Tw T* (\007\036\027\021\026\n\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\t\b \233\204\233 \023\024\f\035\031\032\017\035\026 \024\f\ \027\024\r\026\027\017\036\n \007\035\016 \017)Tj 0 Tw (-)Tj T* (\031\004\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\017\016 \023\030\017\004\017\027 \f\035\024\032\017\ \r\001\017\b\f\016 \023\024\007\b\024\007\024\r.)Tj /T1_3 1 Tf 0.022 Tw 0 -2.436 TD (\026\002\212\006\002\217 1:)Tj /T1_0 1 Tf ( \253\025\026\022\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\r\026\001\036\n \220\021\026\023\036 \024\022\026)Tj 0 Tw (-)Tj -0.015 Tw 0 -1.218 TD (\026\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\ \n\024\013\017 \016\r\035\016\036\021\f\016 \024\f\027\024\r\027\t\n \007\ \035\016 )Tj 0.005 Tw T* (\031\f\021\026\027\024\r\022\017 \007\017\026\020\027\024\026 \r\027\036\ \002\030\033\001\017\027\027\024\020\024 \030\026\027\036\027\017\016 \023\ \030\016\n\024\005 )Tj 0 Tw T* (\022\017\001\022\017?\273)Tj 0.186 Tw T* (\200 \b\024\007\036 \023\030\024\r\036\007\036\027\027\024\020\024 \026\027\ \022\036\021\017\030\024\r\026\027\017\016 \r\t\016\r\035\036\027\024, \004\ \021\024 )Tj 0.235 Tw T* (\020\030\031\023\023\t \030\036\f\023\024\027\007\036\027\021\024\r \027\ \026\004\017\n\024 \030\026\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0.161 Tw T* (\002\024\030\031 \024\f\027\024\r\027\024\020\024 \n\036\021\024\007\026\ \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\025 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj 0.347 Tw T* (\035\017\004\027\t\b \211\204\215 \(\022\030\017\021\036\030\017\005 \205\ \017\001\036\030\026\226\205\030\017\n\026\027\026\226\216\024\035\021\024\ \027\026 )Tj /T1_1 1 Tf 0 Tw T* (\032)Tj /T1_0 1 Tf 0.018 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 328.1108 204.5058 Tm (-10)Tj 0.018 Tw 10 0 0 10 335.9929 201.1758 Tm (;\). \212\035\016 \r\f\036\b \211\204\215 \027\026\017\002\024\035\036\036\ \023\030\036\007\023\024\004\021\017\021\036\035\034\027\t)Tj 0 Tw (-)Tj -0.012 Tw -3.269 -1.218 Td (\n\017 \n\036\021\024\007\026\n\017 \007\017\026\020\027\024\f\021\017\022\ \017 \200\002\217\215\025 \016\r\035\016\035\017\f\034 \023\026\035\034\006\ \036\r\024\036 )Tj 0.163 Tw T* (\030\036\022\021\026\035\034\027\024\036 \017\f\f\035\036\007\024\r\026\027\ \017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\034\033\021\036\030\027\026\016 \021\024\n\024\020\030\026\ )Tj 0 Tw (-)Tj 0 -1.218 TD (\235\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024)Tj /Span<>> BDC ( )Tj EMC (36 \(25; 48\))Tj /Span<>> BDC ( )Tj EMC 8.998 0 Td (%, \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 0.288 Tw -8.998 -1.218 Td [(\222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\t\036\ )0.5(\030\026\035\017\004\017\016 \n\036\032\007\031 \030\026\027\t\n\017 )]TJ -0.118 Tw 0 -1.218 TD (\211\204\215 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\002\024\030\036 \024\f\027\024\r\027\024\020\024 \n\036\021\024\007\ \026 \007\017\026\020\027\024\f\021\017\022\017 \200\002\217\215\025 )Tj 0.024 Tw 0 -1.218 TD (\r\t\016\r\035\036\027\t \007\035\016 \023\026\035\034\006\036\r\024\020\ \024 \030\036\022\021\026\035\034\027\024\020\024 \017\f\f\035\036\007\024\ \r\026\027\017\016 )Tj 0.119 Tw 0 -1.218 TD (\(\022\030\017\021\036\030\017\005 \205\017\001\036\030\026\226\205\030\017\ \n\036\027\026\226\216\024\035\021\024\027\026, )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.119 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (10)Tj 0 Tw 5.83 0 0 5.83 494.785 119.2598 Tm (\2266)Tj /Span<>> BDC ( )Tj EMC 0.119 Tw 10 0 0 10 502.9922 115.9298 Tm (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.714 Tw -19.969 -1.218 Td (\023\030\026\r\022\024\005 \207\036\027\007\032\026\n\017\027\017\226\216\ \024\b\002\036\030\020\026\), \023\030\036\007\023\024\004\017\021\026\036\ \n\024)Tj 0 Tw (-)Tj 0.115 Tw 0 -1.218 TD (\020\024 \b\017\030\031\030\020\026\n\017 \023\036\030\r\024\020\024 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\024\020\024 \211\204\215 \(78 \(50; 95\))Tj /Span<>> BDC ( )Tj EMC 21.351 0 Td (% )Tj -0.02 Tw -21.351 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (40 \(15; 69\) %, \f\024\024\021\r\036\021\f\021\r\036\027\027\024\). \215\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\026\035\034\006\036\r\024\036 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \032\027\024\033\031\ \025\030\027\025\023\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC [(\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025)0.5(\022\t \026\027\030\022\006\022\025\024\n\031\235 \033\031\026\031\212\022\ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.334 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(r)-2(e)-22(s)4.4(p)-9.1(o)-4(n)-4.8(d)-5.3(e)-6.9(n)-0.6(t)-32.9(s a)-9.2(t d)-3(i)5.1(f)-42.4(f)-13.3(e)-6(r)-2(e)-7(n)-0.6(t le)-8.2(v)2.3(e)-6.1(l)-32.4(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(m)-5.3(e)-12.9(d)-3(i)-1.7(c)3.2(a)-4.5(l c)3.2(a)-4.2(r)-2(e)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 198.6752 715.181 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 394.2657 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 436.7854 715.181 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 715.181 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 703.7117 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 198.6752 703.7117 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 266.7067 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 309.2264 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 351.7461 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 394.2657 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 436.7854 703.7117 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 703.7117 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 692.2426 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 70.8661 692.2426 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 692.2426 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 692.2426 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 692.2426 cm 0 0 m 42.77 0 l S Q q 1 0 0 1 436.7854 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 681.0312 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 70.8661 680.7812 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 71.1161 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 198.6752 680.7812 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 198.6752 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 266.7067 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 266.7067 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 351.7461 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 394.2657 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 436.7854 680.7812 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 680.7812 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.3199 cm 0 0 m 127.809 0 l S Q q 1 0 0 1 198.6752 669.3199 cm 0 0 m 68.031 0 l S Q q 1 0 0 1 266.7067 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 309.2264 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 351.7461 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 394.2657 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 436.7854 669.3199 cm 0 0 m 42.52 0 l S Q q 1 0 0 1 479.3051 669.3199 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 216.8551 706.5463 Tm (\255\t\214\002\f\013)Tj 6.7 0 Td (2 \210\006\002\r\b\001)Tj 5.315 0 Td (3 \210\006\002\r\b\001)Tj 5.315 0 Td (4 \210\006\002\r\b\001)Tj 5.315 0 Td (5 \210\006\002\r\b\001)Tj 6.279 0 Td (\026\217\r\n\002)Tj /T1_4 1 Tf 6.458 0.001 Td (\t)Tj /T1_0 1 Tf -53.244 -1.433 Td (\025\024\035\017\004\036\f\021\r\024 \030\036\f\023\024\027\007\036\027\021\ \024\r \(\004\036\035.\))Tj /T1_4 1 Tf 19.53 0 Td (N)Tj /T1_3 1 Tf 6.666 -0.001 Td (24)Tj 5.315 0 Td (20)Tj 5.315 0 Td (22)Tj 5.593 0 Td (9)Tj 5.037 0 Td (75)Tj /T1_0 1 Tf 4.956 0.001 Td (0,066)Tj -52.411 -1.434 Td (\212\024\035\016 )Tj /T1_1 1 Tf 16.761 0 Td (f )Tj /T1_0 1 Tf (\(%\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \212\230)Tj 7.733 0 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(22; 46\))Tj 5.315 0 Td (27)Tj /Span<>> BDC ( )Tj EMC (\(15; 41\))Tj 5.315 0 Td (29)Tj /Span<>> BDC ( )Tj EMC (\(17; 44\))Tj 5.565 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(5; 24\))Tj 6.573 0 Td (100)Tj -47.262 -1.433 Td (\216\017\030\031\030\020\017\004\036\f\022\017\005 \f\021\026\032 \(\020\ \024\007\t\) )Tj /T1_1 1 Tf 17.425 0 Td (M )Tj /T1_0 1 Tf (\(95% \212\230\))Tj 7.068 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(10; 15\))Tj 5.315 0 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(14; 20\))Tj 5.315 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(13; 19\))Tj 5.565 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(8; 18\))Tj 5.065 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(13; 16\))Tj 6.908 0 Td (0,13)Tj /T1_1 1 Tf 7 0 0 7 70.8661 657.8353 Tm (\004\032\022\026\027\007\020\025\022\027: \030\f\t \030\031\f\027\235 \021\ )Tj /Span<>> BDC ( )Tj EMC [(\024\n\031\240\n\020\200 \r\n\020\016\020\025\013 \023\031\007\025\013\027\ 95%-\027 \220\002 \n\020\n \030\f\t \033\020\032\020\026\027\023\032\031\ \021 \033\031\f\022\025\031)0.8(\026\022\020\f\017\025\031\b\031 \032\020\024\033\032\027\030\027\f\027\025\ \022\t. \004\032\027\030\024\023\020\021\f\027\025\031 \023\031\007\025\031\ \027 \032-\016\025\020\007\027\025\022\027 \030\f\t )]TJ 0 -1.2 TD [(\033\032\031\021\027\032\n\022 \024\031\b)28.1(\f\020\024\022\t \030\020\025\025\013\200 \024)]TJ /Span<>> BDC ( )Tj EMC (\032\020\021\025\031\026\027\032\025\013\026 \033\031\f\022\025\031\026\022\ \020\f\017\025\013\026 \032\020\024\033\032\027\030\027\f\027\025\022\027\ \026 \024)Tj /Span<>> BDC ( )Tj EMC [(\031\255\022\030\020\027\026\031\235)0.7( \030\031\f\027\235 25%. \220\f\t \024\023\020\255\020 \033\032\027\030\024\ \023\020\021\f\027\025\013 \024\032\027\030\025\022\027 \016\025\020\007\ \027\025\022\t \022)]TJ /Span<>> BDC ( )Tj EMC (95%-\027 )Tj 0 -1.2 TD (\220\002, \021\013\007\022\024\f\027\025\025\013\027 \026\027\023\031\030\ \031\026 \240\r\023\024\023\032\027\033\020 \022)Tj /Span<>> BDC ( )Tj EMC (\030\f\t \033\032\031\021\027\032\n\022 \031\030\025\031\032\031\030\025\ \031\024\023\022 \024\023\020\255\020 \021)Tj /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\020\200 \022\024\033\031\f\017)0.8(\016\031\021\020\f\022 \031\030\025\031\203\020\n\023\031\032\025\013\235\ \030\022\024\033\027\032\024\022\031\025\025\013\235 \020\025\020\f\022\ \016.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 20.8528 56.0378 Tm (104)Tj ET endstream endobj 961 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.017 Tw 10 0 0 10 42.5197 724.8299 Tm (\035\036\004\036\027\017\016 \023\024\f\021\030\026\007\026\r\001\017\b \ \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\n\017 \030\026\027\036\027\017\016\ \n\017 )Tj 0.009 Tw 0 -1.218 TD (\023\030\016\n\024\005 \022\017\001\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \031\030\024\r\027\016\b \024\022\026\026\ \027\017\016 \n\036\007\017)Tj 0 Tw (-)Tj T* (\006\017\027\f\022\024\005 \023\024\n\024\013\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 663.9399 Tm [(\207)21(\026)45(\024\034\033\031\026)-10(\r\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.238 Tw 10 0 0 10 42.5197 639.5839 Tm (\200 \024\022\021\016\002\030\036 2024 \020. \f\024\021\030\031\007\027\017\ \022\026\n\017 \022\026\235\036\007\030\t \r\024\036\027\027\024-)Tj 0.058 Tw T* (\n\024\030\f\022\024\005 \b\017\030\031\030\020\017\017 \023\030\024\r\036\ \007\036\027\024 \024\002\f\036\030\r\026\006\017\024\027\027\024\036 \024\ \007\027\024)Tj 0 Tw (-)Tj -0.012 Tw T* (\n\024\n\036\027\021\027\024\036 \(\023\024\023\036\030\036\004\027\024\036\ \) \017\f\f\035\036\007\024\r\026\027\017\036, \026\022\035\033\004\026\ \r\001\036)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\036\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\027\017\n\027\024\n \026\027\022\036\021\017\030\024\r\026\027\ \017\017 75 \b\017\030\031\030\020\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\021.\004. )Tj 0.189 Tw 0 -1.218 TD [(\022\024\035\024\023\030\024\022\021\024\035\024\020\024\r, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b )0.5(\211\204\215: )0.5(2 \031\030\024\r\036\027\034)]TJ /Span<>> BDC ( )Tj EMC (\227 )Tj 0.057 Tw T* (\023\036\030\036\007\024\r\026\016 \n\036\007\017\006\017\027\f\022\026\016\ \020\030\031\023\023\026, 3 \031\030\024\r\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \n\027\024\020\024)Tj 0 Tw (-)Tj -0.031 Tw T* [(\023\030\024\235\017\035\034\027\t\005 )0.6(\r\024\036\027\027\t\005 )0.5(\020\024\f\023\017\021\026\035\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.708 0 Td [(\002\026\036 )0.5(\n\036\007\017\006\017\027\f\022\024)]TJ 0 Tw (-)Tj 0.267 Tw -14.708 -1.218 Td (\020\024 \024\021\030\016\007\026 \f\023\036\006\017\026\035\034\027\024\ \020\024 \027\026\027\026\004\036\027\017\016 \017\035\017 \035\036\004\ \036\002\027\024\005 )Tj 0.132 Tw 0 -1.218 TD (\024\030\020\026\027\017\026\006\017\017 \204\017\027\007\030\026\r\026\ \f)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\024\005 \031\f\017\035\036\027\017\016, 4 \031\030\024\ )Tj 0 Tw (-)Tj 0.157 Tw 0 -1.218 TD (\r\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \024\022\030\031\032\027\024\005 \r\024\036\027\027\t\005 \020\024\f\ \023\017\021\026\035\034 \f)Tj /Span<>> BDC ( )Tj EMC (\235\017\035\017\026\035\026\n\017 )Tj -0.019 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\027\t\n\017 \023\024\007\030\026\007\036\ \035\036\027\017\016\n\017, 5 \031\030\024\r\036\027\034)Tj /Span<>> BDC ( )Tj EMC (\227 \020\035\026\r)Tj 0 Tw (-)Tj 0.209 Tw T* (\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030\026\035\034\027\t\036 \r\024\036\027\027\024-\n\036\ \007\017\006\017\027\f\022\017\036 \024\030\020\026\027\017\026)Tj 0 Tw (-)Tj 0.228 Tw T* (\006\017\017. \202\027\024\027\017\n\027\024\036 \026\027\022\036\021\017\ \030\024\r\026\027\017\036 \023\030\024\r\024\007\017\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.102 Tw T* [(\023\024\035\034\024\r\026\027\017\036\n )0.6(\024\023\030\024\f\027\017\022\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 11.717 0 Td [(\r\017\007\036 )0.5(\024\027\035\026\005\027-\235\024\030\n\t, )0.6(\002\036 )]TJ 0.091 Tw -11.717 -1.218 Td (\031\022\026\026\027\017\016 \035\017\004\027\t\b \007\026\027\027\t\b \ \b\017\030\031\030\020\026\n\017-\030\036\f\023\024\027\007\036\027\021\026\ \n\017. )Tj 0.54 Tw T* [(\025\030\017\021\036\030\017\017 )0.5(\r\022\035\033\004\036\027\017\016: )0.5(\b\017\030\031\030\020-\030\036\f\023\024\027\007\036\027\021 )0.6(\007\024\035\032\036\027 )]TJ 0.131 Tw T* (\017\n\036\021\034 \024\023\t\021 \024\022\026\026\027\017\016 \b\017\030\ \031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\024\007)Tj 0 Tw (-)Tj 0.142 Tw T* (\027\024\n \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\004\017\f\035\036\027\027\t\b \211\204\215. \025\030\017\ \021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016: )Tj -0.003 Tw T* (\024\021\f\031\021\f\021\r\017\036 \031)Tj /Span<>> BDC ( )Tj EMC (\030\036\f\023\024\027\007\036\027\021\026 \024\023\t\021\026 \024\022\026\ \026\027\017\016 \b\017\030\031\030\020\017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\005 \023\024\n\024\013\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\004\017\f\035\036\027\027\t\b \211\204\215.)Tj 0.092 Tw T* [(\217\036\f\023\024\027\007\036\027\021\026\n )0.6(\023\030\036\007\035\026\020\026\035\024\f\034 )0.5(\024\021\r\036\021\017\021\034 )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 17.213 0 Td [(9 )0.5(\r\024\023\030\024\f\024\r, )]TJ 0.267 Tw -17.213 -1.218 Td (\022\026\f\026\033\013\017\b\f\016 \n\036\021\024\007\024\r \007\017\026\ \020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024)Tj 0 Tw (-)Tj 0.185 Tw T* (\020\024 \035\036\004\036\027\017\016 \200\002\217\215\025, \f)Tj /Span<>> BDC ( )Tj EMC [(\r\024\n\024\032\027\024\f\021\034\033 )0.5(\r\t\002\024\030\026 \024\007\027\024\020\024 )]TJ 0.193 Tw T* (\017\035\017 \027\036\f\022\024\035\034\022\017\b \023\030\036\007\f\021\ \026\r\035\036\027\027\t\b \024\021\r\036\021\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r \027\036\022\024)Tj 0 Tw (-)Tj 0.114 Tw T* (\021\024\030\t\b \r\024\023\030\024\f\026\b \007\026\021\034 \f\r\024\005\ \r\026\030\017\026\027\021 \024\021\r\036\021\026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\). )Tj 0.628 Tw T* (\215\024\035\031\004\036\027\027\t\036 \024\021\r\036\021\t \030\036\f\023\ \024\027\007\036\027\021\024\r \030\026\f\023\030\036\007\036\035\036\027\ \t )Tj 0 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\211\204\215.)Tj 0.093 Tw T* [(\025\024\027\036\004\027\t\n\017 \021\024\004\022\026\n\017 \017\f\f\035\ \036\007\024\r\026\027\017\016 )0.5(\016\r\035\016\035\024\f\034 \023\024\035\031\004\036)]TJ 0 Tw (-)Tj 0.243 Tw T* (\027\017\036 \f\r\036\007\036\027\017\005 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\r\036\030\032\036\027\027\024\f\021\017 \b\017\030\031\030\020\ \024\r-\030\036\f\023\024\027)Tj 0 Tw (-)Tj 0.231 Tw T* (\007\036\027\021\024\r \022)Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\027\t\n \007\017\026\020\027\024\f\021\ \017\004\036\f\022\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026)Tj 0 Tw (-)Tj 0.351 Tw T* (\021\017\r\027\t\n \n\036\021\024\007\026\n \035\036\004\036\027\017\016\ \200\002\217\215\025, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \024\006\036\027\022\026 )Tj 0 Tw T* (\r\027\031\021\030\036\027\027\036\005 \f\024\020\035\026\f\024\r\026\027\ \027\024\f\021\017.)Tj /T1_3 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf -0.016 Tc -0.064 Tw 0 -1.218 TD [(\204\036\021\024\007\t )0.5(\024\023\017\f\026\021\036\035\034\027\024\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 9.506 0 Td [(\026\027\026\035\017\021\017\004\036\f\022\024\005 )0.5(\f\021\026\021\017\f\021\017\022\017, )0.5(\023\030\017)]TJ 0 Tc 0 Tw (-)Tj -0.016 Tc 0.055 Tw -9.506 -1.218 Td (\n\036\027\036\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f\f\035\036\007\024\r\026\027\017\017, \030\036\ \026\035\017\024\r\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026)Tj 0 Tc 0 Tw (-)Tj -0.016 Tc 0.11 Tw T* [(\021\017\f\021\017\004\036\f\022\017\b \023\030\024\020\030\026\n\n\026\b\ : S)15(t)15(a)15(tX)-14(a)-17(c)-16(t v. 11.1 \(\253Cy)-16(tel Co.\273,)-16( )]TJ 0.193 Tw T* [(USA\), P)40(ast \(\r\036\030\f\017\016 5.2.2\) [7]; L)-32(ang)17(test \(ht)-30(tps://l)-16(ang)]TJ 0 Tc 0 Tw (-)Tj -0.016 Tc 0.618 Tw T* [(test.jp/shiny/chi/\); A)-25(gr)-24(eeS)15(t)15(a)15(t \(ht)-30(tps://a)-17(gr)-24(eest)15(a)15(t360.)]TJ 0 Tw 0 -1.218 TD [(com/\); L)35(eP)25(A)16(C \(ht)-30(tps://er)-37(is62.eu/Er)-37(isL)35.1(eP)25.1(A)15.9(C.html\).)]TJ 0 Tc 0.08 Tw 0 -1.218 TD (\037\036\027\021\030\026\035\034\027\t\036 \021\036\027\007\036\027\006\017\ \017 \023\030\036\007\f\021\026\r\035\036\027\t \f\030\036\007\027\017\n\ \027\026)Tj 0 Tw (-)Tj -0.037 Tw 0 -1.218 TD (\004\036\027\017\036\n \()Tj /T1_4 1 Tf 0 Tw (\215)Tj /T1_1 1 Tf -0.037 Tw (\) \017\035\017 \n\036\007\017\026\027\024\005 \()Tj /T1_4 1 Tf 0 Tw (\215\027)Tj /T1_1 1 Tf -0.037 Tw (\) \r)Tj /Span<>> BDC ( )Tj EMC (\026\r\017\f\017\n\024\f\021\017 \024\021 \f\024\024\021)Tj 0 Tw (-)Tj 0.123 Tw 0 -1.218 TD (\r\036\021\f\021\r\017\016 \r\t\002\024\030\024\022 \023\026\030\026\n\036\ \021\030\017\004\036\f\022\024\n\031 \017\035\017 \027\036\023\026\030\026\ \n\036)Tj 0 Tw (-)Tj 0.288 Tw 0 -1.218 TD (\021\030\017\004\036\f\022\024\n\031 \030\026\f\023\030\036\007\036\035\036\ \027\017\033. \222\024\024\021\r\036\021\f\021\r\017\036 \r\t\002\024\030\ \022\017 )Tj 0.009 Tw 0 -1.218 TD (\027\024\030\n\026\035\034\027\024\n\031 \030\026\f\023\030\036\007\036\035\ \036\027\017\033 \024\023\030\036\007\036\035\016\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj 0.912 Tw T* (\022\030\017\021\036\030\017\036\r \231\026\023\017\030\024\226\211\017\035\ \022\026, \202\027\007\036\030\f\024\027\026\226\212\026\030\035\017\027\ \020\026, )Tj 0 Tw T* (\214\017\035\035\017\036\235\024\030\f\026, \240\026\030\022\036\226\207\ \036\030\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0.389 Tw 9 0 0 9 274.9606 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \205\033\022\024\031\n \021\031\033\032\031\024\031\021, \024\203\031\032\ \026\022\032\031\021\020\025\025\013\200 \032\020\240\031\007\027\235 )Tj 0 Tw 0 -1.2 TD (\b\032\r\033\033\031\235 \030\f\t \033\032\031\021\027\030\027\025\022\t\ \022\024\024\f\027\030\031\021\020\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.233 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( )0.5(1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.206 Tw 3.529 0 Td [( )0.5(L)-1.2(i)6.6(s)-14.8(t )0.6(o)4(f)]TJ /Span<>> BDC ( )Tj EMC 3.506 0 Td [(q)-3(u)-3.2(e)-22(s)-14.8(t)-29.1(i)-1.3(o)-4(n)3.7(s )0.5(g)-6.8(e)-7(n)-2.4(e)-6(r)3.3(a)-9.2(t)-1.6(e)-12.9(d )0.6(b)-2.4(y )0.5(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC 11.722 0 Td [(w)2.2(o)-3(r)-6.8(k)-22.4(i)4(n)-0.6(g )0.5(g)-1.5(r)-2(o)-3.4(u)-2.3(p )]TJ 0 Tw -18.757 -1.2 Td [(t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-3.9(n)-4.8(d)0.8(u)-3.7(c)-32.4(t t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.8(d)-7.2(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 274.9606 693.581 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 684.0626 cm 0 0 m 0 9.268 l S Q q 1 0 0 1 495.4587 684.0626 cm 0 0 m 0 9.268 l S Q q 1 0 0 1 274.9606 683.8126 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 655.2941 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 655.2941 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 655.0441 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 588.5336 cm 0 0 m 0 66.26 l S Q q 1 0 0 1 495.4587 588.5336 cm 0 0 m 0 66.26 l S Q q 1 0 0 1 274.9606 588.2836 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 559.7652 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 559.7652 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 559.5152 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 521.5047 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 495.4587 521.5047 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 274.9606 521.2547 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 492.7363 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 492.7363 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 492.4863 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 473.4758 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 495.4587 473.4758 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 274.9606 473.2258 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 444.7073 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 444.7073 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 444.4573 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 406.4469 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 495.4587 406.4469 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 274.9606 406.1969 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 377.6784 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 377.6784 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 377.4284 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 339.4179 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 495.4587 339.4179 cm 0 0 m 0 37.76 l S Q q 1 0 0 1 274.9606 339.1679 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 291.6495 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 495.4587 291.6495 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 274.9606 291.3995 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 281.889 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 495.4587 281.889 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 274.9606 281.639 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 234.1206 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 495.4587 234.1206 cm 0 0 m 0 47.268 l S Q q 1 0 0 1 274.9606 233.8706 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 224.3601 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 495.4587 224.3601 cm 0 0 m 0 9.26 l S Q q 1 0 0 1 274.9606 224.1101 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 195.5916 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 495.4587 195.5916 cm 0 0 m 0 28.268 l S Q q 1 0 0 1 274.9606 195.3416 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 119.3312 cm 0 0 m 0 75.76 l S Q q 1 0 0 1 495.4587 119.3312 cm 0 0 m 0 75.76 l S Q q 1 0 0 1 274.9606 119.0812 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 100.0627 cm 0 0 m 0 18.768 l S Q q 1 0 0 1 495.4587 100.0627 cm 0 0 m 0 18.768 l S Q q 1 0 0 1 274.9606 99.8127 cm 0 0 m 220.748 0 l S Q q 1 0 0 1 275.2106 80.8022 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 495.4587 80.8022 cm 0 0 m 0 18.76 l S Q q 1 0 0 1 274.9606 80.5522 cm 0 0 m 220.748 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 336.2673 685.7968 Tm (\026\002\212\006\002\217 \217)Tj /Span<>> BDC ( )Tj EMC (\004\006\t\004\b\003\004\214\t \002\003\r\003\004)Tj -7.278 -1.221 Td (1.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\002\r \t\217\217\f\r\240\002\004\b\t\r \b\004)Tj /Span<>> BDC ( )Tj EMC (\004\230\r\214 \234\003\004\212\r \002\220\004\213\004\b\t\235 )Tj -1.352 -1.187 Td (\216\t\006\210\006\n\t\201\r\217\220\002\005 \212\002\214\002\227\t \235\ \f\235\r\003\217\235 \002\217\b\002\b\013\214 \240\f\235 \210\217\003\004\ \b\002\220\t )Tj 0 -1.187 TD (\240\t\004\n\b\002\213\004 \b\r\206\006\211\230\t\b\b\002\n\002 \006\004\ \b\r\b\t\235 \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\215\026\035\034\006\036\r\024\036 \030\036\022\021\026\035\034\027\024\036\ \017\f\f\035\036\007\024\r\026\027\017\036)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\217\036\027\021\020\036\027\024\020\030\026\235\017\016)Tj 0 Tw 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\202\027\024\f\022\024\023\017\016, \030\036\022\021\024\f\022\024\023\017\ \016, \024\f\n\024\021\030 \r)Tj /Span<>> BDC ( )Tj EMC (\036\030\022\026\035\026\b)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\025\024\n\023\034\033\021\036\030\027\026\016 )-232.9(\021\024\n\024\020\030\026\235\017\016)]TJ T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (FAST-\023\030\024\021\024\022\024\035)Tj T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\205\017\002\030\024\022\024\035\024\027\024\f\022\024\023\017\016)Tj T* (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\204\026\020\027\017\021\027\024-\030\036\024\027\026\027\f\027\026\016\ )-232.8(\021\024\n\024\020\030\026\235\017\016)]TJ /T1_5 1 Tf 0 Tw 0 -1.221 TD (2.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\002\005 \217\212\002\217\002\206 \226\002\006\214\t\006\002\ \004\b\t\235 \240\t\r\006\217\t\002\b\b\002\005 \220\002\f\002\217\003\ \002\214\013 )Tj -1.352 -1.187 Td (\235\f\235\r\003\217\235 \212\006\r\240\212\002\201\003\t\003\r\f\001\b\ \013\214 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\240\r\217\003\006\210\220\003\t\b\002\214 )Tj 0 -1.187 TD (\(\240\002)Tj /Span<>> BDC ( )Tj EMC (\274)Tj /Span<>> BDC ( )Tj EMC (\002\220\006\210\202\b\002\217\003\t\) \b\r\206\006\211\230\t\b\b\002\214\ \006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\212\r\031- \017\035\017 \024\007\027\024\f\021\r\024\035\034\027\026\016\ )Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\200\f\036\020\007\026 \007\r\031\f\021\r\024\035\034\027\026\016 \023\036\ \021\035\036\r\026\016)Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\200\f\036\020\007\026 \024\007\027\024\f\021\r\024\035\034\027\026\016 \ \022\024\027\006\036\r\026\016)Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\203\036 \r\f\036\020\007\026 \235\024\030\n\017\030\031\033)Tj /T1_5 1 Tf -1.056 -1.221 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\200\006\t\214\r\b\235\r\003\r \f\t \026\013 \003\006\004\b\217\f\211\214\ \t\b\004\f\001\b\002\r \210\230\t\004\b\t\r \240\r\226\r\220\003\004 )Tj -1.352 -1.187 Td (\212\006\235\214\002\005 \220\t\230\220\t \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\240\r\217\003\006\210\220\003\t\b\002\214 \(\240\002 \274 \002\220\ \006\210\202\b\002\217\003\t\) )Tj 0 -1.187 TD (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t \212\006\235\214\002\ \005 \220\t\230\220\t?)Tj /T1_1 1 Tf -0.233 Tw 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\212\026, )-233(\023\030\017\n\036\027\016\033)]TJ 0 Tw 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\203\036\021, \027\036 \023\030\017\n\036\027\016\033)Tj /T1_5 1 Tf -1.056 -1.221 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\t\214 \217\212\002\217\002\206\002\214 \026\013 \013\212\002\ \f\b\235\r\003\r \240\t\217\003\004\f\001\b\002\r \002\003\214\013\004\b\ \t\r )Tj -1.352 -1.187 Td (\002\003\220\f\211\201\r\b\b\002\005 \201\004\217\003\t \003\002\f\217\003\ \002\005 \220\t\230\220\t \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 )Tj T* (\006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \026\027\026\035\034\027\t\005 \022\026\027\026\035 \(\ \030\036\021\030\024\020\030\026\007\027\024\))Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \f\021\024\n\031 \(\026\027\021\036\020\030\026\007\027\ \024\))Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \f\021\024\n\031 \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\t\005 \022\026\027\026\035)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\203\036 )-233(\024\021\n\t\r\026\033)]TJ /T1_5 1 Tf 0 Tw 0 -1.221 TD (5.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\t\214 \217\212\002\217\002\206\002\214 \026\013 \013\212\002\ \f\b\235\r\003\r \212\r\006\t\b\r\004\f\001\b\002\r )Tj -1.352 -1.187 Td (\240\006\r\b\t\006\002\004\b\t\r \220\f\r\003\201\004\003\002\201\b\013\ \216 \212\006\002\217\003\006\004\b\217\003 \003\004\213\004 )Tj 0 -1.187 TD (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t \212\006\235\214\002\ \005 \220\t\230\220\t?)Tj /T1_1 1 Tf -0.233 Tw 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\207\017\035\026\021\036\030\026\035\034\027\024 )-232.9(\023\026\030\026\030\036\022\021\026\035\034\027\024)]TJ 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\215\030\036\f\026\022\030\026\035\034\027\024)Tj 0 Tw T* (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\232\036\030\036 \030\026\027\036\r\024\005 \022\026\027\026\035)Tj -0.233 Tw -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC [(\203\036 )-233(\007\030\036\027\017\030\031\033)]TJ /T1_5 1 Tf 0 Tw 0 -1.221 TD (6.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\026 \216\002\240\r \013\212\002\f\b\r\b\t\235 \212\r\006\t\b\r\004\f\001\ \b\002\n\002 \240\006\r\b\t\006\002\004\b\t\235 )Tj -1.352 -1.187 Td (\220\f\r\003\201\004\003\002\201\b\013\216 \212\006\002\217\003\006\004\b\ \217\003 \003\004\213\004 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 )Tj 0 -1.187 TD (\006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t, \b\004)Tj /Span<>> BDC ( )Tj EMC (\220\004\220\210\211 \n\f\210\206\t\b\210 \210\217\003\004\b\004\f\t\004\ \r\003\r )Tj T* (\212\004\006\004\006\r\220\003\004\f\001\b\013\005 \240\006\r\b\004\202 \ \(\217\214\) \t)Tj /Span<>> BDC ( )Tj EMC (\220\004\220\t\214 \002\006\t\r\b\003\t\006\002\214 )Tj T* (\212\002\f\001\213\210\r\003\r\217\001 \240\f\235 \234\003\002\n\002?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\222\r\024\002\024\007\027\t\005 \r\026\030\017\026\027\021 \024\021\r\036\ \021\026)Tj /T1_5 1 Tf -1.056 -1.221 Td (7.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\222\220\004\202\t\003\r \212\002\217\f\r\240\002\004\003\r\f\001\b\002\ \217\003\001 \013\212\002\f\b\r\b\t\235 \234\003\004\212\002 )Tj -1.352 -1.187 Td (\002\212\r\006\004\003\t\b\002\n\002 \214\r\230\004\003\r\f\001\217\003\ \004 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t )Tj 0 -1.187 TD (\212\006\235\214\002\005 \220\t\230\220\t \(\226\002\006\214\t\006\210\211\ \220\002\f\002\217\003\002\214\210/\217\003\002\214\210; \210\230\t\004\ \211 )Tj T* (\f\004\212\004\006\002\003\002\214\b\210\211 \006\004\b\210; \002\003\214\ \013\004\211 \240\t\217\003\004\f\001\b\210\211 \201\004\217\003\001 \220\ \t\230\220\t; )Tj T* (\240\006\r\b\t\006\210\211 \212\004\006\004\006\r\220\003\004\f\001\b\210\ \211 \220\f\r\003\201\004\003\220\210\))Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\222\r\024\002\024\007\027\t\005 \r\026\030\017\026\027\021 \024\021\r\036\ \021\026)Tj /T1_5 1 Tf -1.056 -1.221 Td (8.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\021\004\220\004\235 \002\217\b\002\b\004\235 \204\r\f\001 \013\212\002\ \f\b\r\b\t\235 \006\210\003\t\b\b\002\n\002 )Tj -1.352 -1.187 Td (\212\004\006\004\006\r\220\003\004\f\001\b\002\n\002 \240\006\r\b\t\006\002\ \004\b\t\235 \212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 )Tj 0 -1.187 TD (\006\004\b\r\b\t\t \212\006\235\214\002\005 \220\t\230\220\t?)Tj /T1_1 1 Tf 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\215\030\024\235\017\035\026\022\021\017\022\026 \017\027\235\036\022\006\ \017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024 \f\021\ \024\030\024\027\t )Tj 0 -1.187 TD (\022\035\036\021\004\026\021\022\017 \021\026\026;)Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\222\r\024\036\r\030\036\n\036\027\027\026\016 \007\017\026\020\027\024\f\ \021\017\022\026 \017\027\235\036\022\006\017\024\027\027\t\b \024\f\035\ \024\032\027\036\027\017\005 \f\024 )Tj T* (\f\021\024\030\024\027\t \022\035\036\021\004\026\021\022\017 \021\026\026\ )Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\217\036\026\035\017\026\006\017\016 \031\022\026\026\027\017\005 \030\ \036\020\035\026\n\036\027\021\017\030\031\033\013\017\b \007\024\022\031\ \n\036\027\021\024\r )Tj T* (\(\031\022\026\026\027\017\005 \f\021\026\030\001\036\020\024 \n\036\007\ \017\006\017\027\f\022\024\020\024 \027\026\004\026\035\034\027\017\022\026\ \))Tj -1.056 -1.187 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\203\036 \r\t\023\024\035\027\016\033 \030\031\021\017\027\027\024\036 \007\ \030\036\027\017\030\024\r\026\027\017\036 \023\026\030\026\030\036\022\021\ \026\035\034\027\024\005 )Tj T* (\022\035\036\021\004\026\021\022\017)Tj /T1_5 1 Tf -1.056 -1.221 Td (9.)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td (\026\013\212\002\f\b\235\r\003\r \f\t \026\013 \240\t\210\f\001\217\t\211\ \217\226\t\b\220\003\r\006\004 )Tj -1.352 -1.187 Td (\212\006\t)Tj /Span<>> BDC ( )Tj EMC (\b\r\206\006\211\230\t\b\b\002\214 \006\004\b\r\b\t\t \212\006\235\214\002\ \005 \220\t\230\220\t?)Tj /T1_1 1 Tf -0.233 Tw 0 -1.22 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\212\026)Tj 0 -1.187 TD (\226)Tj /Span<>> BDC [( )-500( )]TJ EMC (\203\036\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 505.4771 56.0378 Tm (103)Tj ET endstream endobj 960 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 551.2534 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 551.2534 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 514.0455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 514.0455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 459.9764 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf -0.001 Tw 9 0 0 9 119.0551 730.4919 Tm [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: in October 2024, an obser)-41.9(v)16(ational cross-sectional study for patients with e)-15(xtraper)-36.9(itoneal )]TJ 0.098 Tw 0 -1.111 TD [(rectal w)12(ounds w)13(as done using an anon)11(ymous q)14(uestionnaire online, in which 75 surg)12(eons took par)-40(t. R)21(espondents )]TJ 0.042 Tw T* [(w)12(ere divided into four g)14(roups depending on the character)-36.9(istics of the medical ev)16(acuation stag)12(e. Inclusion cr)-36.9(iter)-37(ia: )]TJ 0.045 Tw T* [(the respondent surg)12.1(eon must hav)13(e e)-15(xper)-37(ience in p)46(roviding surgical care at one of the listed lev)12.9(els of medical care. )]TJ 0.023 Tw T* [(Exclusion cr)-37(iter)-37(ia: the respondent has no e)-15(xper)-37(ience in p)45.9(roviding surgical care at the listed lev)13(els of medical care.)]TJ -0.006 Tc -0.026 Tw 0 -1.111 TD [(RESUL)30.1(T)-10(S: a sur)-42(v)13(ey of surg)12(eons at v)16(ar)-37(ious lev)13(els of medical care rev)13(ealed a lack of or low inter)-14(nal consistency in most of)-6( )]TJ 0.02 Tw 0 -1.111 TD [(the respondents)33(\222 answ)12.1(ers at each lev)13(el of medical care. A moderate deg)14(ree of consistency w)13(as achiev)13(ed when answ)12(er)]TJ 0 Tc 0 Tw 44.743 0 Td (-)Tj -0.006 Tc 0.003 Tw -44.743 -1.111 Td [(ing )0.6(q)14(uestions )0.6(about )0.6(the )0.5(method )0.5(and )0.5(pur)-18(poses )0.5(of )0.6(per)-34(for)-14(ming )0.5(routine )0.5(drainag)12(e )0.6(of )0.5(pelvic )0.5(cellular )0.5(spaces. )0.6(In )0.5(the )0.6(answ)12(ers)-6( )]TJ 0.047 Tw T* [(to )0.5(the )0.5(q)14(uestion )0.5(about )0.5(the )0.5(seq)14(uence )0.5(of )0.5(per)-34(for)-14(ming )0.5(surgical techniq)14(ues )0.5(for )0.5(e)-15(xtraper)-36.9(itoneal injur)-37(ies )0.5(of )0.5(the )0.5(rectum, the)-5.9( )]TJ 0.023 Tw T* [(A)26(C1 Gv)13(et coef)-40(f)-43(icient app)46(roaches the mean deg)13.9(ree of ag)14(reement \(0.383 \(95% conf)-43(idence inter)-41.9(v)16(al: 0.119; 0.647\)\).)]TJ 0 Tc 0.018 Tw T* [(C)21(ON)22(CLUSION: one of the op)13(tions for unif)-43(ied app)46(roach to p)46(roviding surgical care for e)-15.1(xtraper)-37(itoneal rectal w)12(ounds is )]TJ 0.016 Tw T* [(to conduct a study using by the Delphi method with the in)11(v)13(olv)13(ement of a g)14(roup of e)-15(xper)-39.9(ts, follow)12(ed by the dev)13(elop)]TJ 0 Tw (-)Tj 0.043 Tw T* [(ment and im)16(plementation, based on a consensus decision, of algor)-36.9(ithms for the treatment of this type of injur)-43(y at )]TJ 0.023 Tw T* [(the stag)12(es of medical ev)16(acuation.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 585.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.099 Tw 4.948 0 Td [( e)-15(xtraper)-37(itoneal rectal injur)-36.9(ies, 4D-concep)13(t, d)26(amag)12(e control, multi-stag)12(e surgical treatment, gunsho)13(t w)12(ounds, pararectal drainag)12.1(e, )]TJ 0.023 Tw -4.953 -1.2 Td [(stag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(medical ev)16(acuation)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.037 Tc -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( )0.6(C)-17.5(I)-15.6(T)45.4(A)37.5(T)-24.5(I)-1.2(ON:)]TJ /T1_2 1 Tf 0.023 Tc 0.032 Tw 6.467 0 Td [( )0.5(S)-12.1(u)-7.6(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 2.976 0 Td [(D)16.4(.)-23.9(A)-23(.)-23.5(, )0.5(E)-25.2(s)-22.9(e)-18(l)-23.6(e)-15.9(v)-51.7(i)-5(c)-10.2(h)]TJ /Span<>> BDC ( )Tj EMC 6.755 0 Td [(R)-21.4(.)40.6(V)39.7(.)-23.5(, )0.5(A)-11.7(l)-16.7(i)-3.2(m)-12.4(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 5.408 0 Td [(P)107.7(.)-23.9(A)-23(.)-23.5(, )0.5(B)-16.4(a)-11.4(l)-8.2(y)-21.5(u)-7.6(r)-30.8(a)]TJ /Span<>> BDC ( )Tj EMC 5.761 0 Td [(O)11.4(.)40.6(V)39.7(.)-23.5(, )0.5(R)-6.5(u)-7(m)-15.4(y)-24.2(a)-7.6(n)-17.3(t)-48.9(s)-22.9(e)-15.8(v)]TJ /Span<>> BDC ( )Tj EMC 7.696 0 Td [(V)39.7(.)-1.9(N)-2.8(.)-23.5(, )0.5(B)-16.4(a)-10.2(r)-18.1(d)-9.3(a)-11.2(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 6.486 0 Td [(S)-9.6(.)-1.9(N)-2.8(.)-23.5(, )0.5(Z)-17.7(o)-15.8(t)-21.9(o)-10.3(v )0.5(K)-27(.)51.7(Y)12.6(u)-9(.)-23.5(, )0.5(O)-30.3(v)-11.6(c)-10.2(h)-14(i)-3.2(n)-5.7(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC 13.286 0 Td [(D)16.4(.)40.6(V)39.7(.)-23.5(,)23( )]TJ 0.003 Tw -54.841 -1.2 Td [(D)-34(y)-27.5(m)-6.2(n)-14(i)-6.6(k)-3.7(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-23(.)-23.5(, K)-11.2(o)-11.8(r)-42.9(z)-12.6(h)-7(u)-9.6(k)]TJ /Span<>> BDC ( )Tj EMC [(M)-7(.)-27(S)-9.6(. C)-16.5(o)-9.2(n)-17.3(t)-30.8(r)-15.7(o)-10.3(v)-18.7(e)-12.1(r)-30.3(s)-26.1(i)-5.1(a)-11.4(l i)-7.4(s)-22.3(s)-8.8(u)-12.5(e)-22.8(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(d)-15.8(i)-5.1(a)-10.8(g)-8.8(n)-11.9(o)-15.8(s)-26.1(i)-7.4(s a)-7.6(n)-14.5(d m)-8.1(u)-8.4(l)-15.4(t)-46.2(i)-12.8(-)-13.5(s)-29.3(t)-36.8(a)-10.8(g)-14.4(e s)-8.8(u)-7.6(r)-16.7(g)-28.9(i)-5(c)-21.5(a)-11.4(l t)-30.8(r)-19(e)-13(a)-18.2(t)-26.1(m)-16.6(e)-11.5(n)-17.3(t i)-3.2(n)]TJ /Span<>> BDC ( )Tj EMC [(p)-20(a)-18.2(t)-46.2(i)-11(e)-11.5(n)-17.3(t)-48.9(s w)-45.7(i)-15.8(t)-26.1(h e)-33.1(x)-44.8(t)-30.8(r)-30.8(a)-8.8(p)-24.7(e)-12.1(r)-56.4(i)-15.8(t)-21.9(o)-9.2(n)-16.1(e)-13(a)-11.4(l)23( )]TJ 0.024 Tw 0 -1.2 TD [(r)-19.1(e)-19.1(c)-41.5(t)-36.8(a)-11.4(l w)-13.5(o)-13.3(u)-5(n)-14.5(d)-24.7(s)-15.4(. )]TJ /T1_0 1 Tf 0.033 Tc -0.033 Tw 6.718 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_2 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)20.9(1)14(0)-1.5(1)26.4(\226)50.8(1)29.8(1)0.9(5)6.9(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. )0.5(h)-17.2(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.7(2)-1.4(5)-23.5(-)55.2(1)26.8(-)55.2(1)14(0)-1.6(1)26.9(-)55.2(1)29.7(1)0.9(5)]TJ /T1_1 1 Tf 0.01 Tc 0.1 Tw -13.733 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.105 Tw 10.74 0 Td ( \036\024\027\f\027\021\022\007 \206\031\026\020\025 \211\f\020\030\022\026\ \022\032\031\021\022\007, \214\216\221\211\217\210 \211\217 \253\211\031\ \027\025\025\031-\026\027\030\022\006\022\025\024\n\020\t \020\n\020\030\ \027\026\022\t \022\026. \205.\215.)Tj /Span<>> BDC ( )Tj EMC (\202\022\032\031\021\020\273, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\003\n\020\030\027\026\022\n\020 )Tj 0.023 Tw -10.745 -1.2 Td (\035\027\240\027\030\027\021\020, \030.)Tj /Span<>> BDC ( )Tj EMC (6, \205\020\025\n\023-\004\027\023\027\032\240\r\032\b, 194044, \206\031\ \024\024\022\t; \023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7 \(911\) 128-21-05; e-mail: r_eselevich@mail.ru)Tj /T1_1 1 Tf 0.01 Tc 0.057 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.062 Tw 14.129 0 Td [( Eselevich R.V)61(., S.M.)]TJ /Span<>> BDC ( )Tj EMC [(Kirov Militar)-42.9(y Medical Academ)11.1(y)41.9(, Ak)11(ademik)11.1(a Lebedev)16.1(a st., 6J, Saint P)15(etersburg, 194044, )]TJ 0.023 Tw -14.134 -1.2 Td [(R)22(ussia;)]TJ /Span<>> BDC ( )Tj EMC (tel.: +7 \(911\) 128-21-05; e-mail: r_eselevich@mail.ru)Tj 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 18.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 18.06.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 396.0239 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf -0.01 Tc 0.168 Tw 10 0 0 10 70.8661 371.6679 Tm (\210\020\027\036\f\021\030\036\035\034\027\t\036 \030\026\027\036\027\017\ \016 \r\027\036\002\030\033\001\017\027\027\024\020\024 \024\021\007\036\ \035\026 \023\030\016)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.082 Tw 0 -1.218 TD (\n\024\005 \022\017\001\022\017 \016\r\035\016\033\021\f\016 \024\007\027\ \017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \021\016\032\036\035\t\b \r\017)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.047 Tw T* (\007\024\r \023\024\r\030\036\032\007\036\027\017\016 \024\030\020\026\027\ \024\r \032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\021\026\026, \023\030\036\007\f\021\026\r\035\016\016)-10( )]TJ 0.099 Tw T* [(\f\024\002\024\005 )0.6(\026\022\021\031\026\035\034\027\031\033 )0.5(\023\030\024\002\035\036\n\031 )0.5(\f\024\r\030\036\n\036\027\027\024\005 )0.5(\002\024\036\r\024\005 )0.5(\b\017)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc -0.024 Tw T* (\030\031\030\020\017\004\036\f\022\024\005 \021\030\026\r\n\t. \212\024\035\ \016 \030\026\027\036\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC [(\r\027\036\002\030\033\001\017\027\027\t\n\017)-10( )]TJ 0.11 Tw T* [(\030\026\027\036\027\017\016\n\017 \023\030\016\n\024\005 \022\017\001\022\ \017 \(\200\002\217\215\025\) \007\024\f\021\017\020\026\036\021 3,4% \024\ \021)-10( )]TJ -0.026 Tw T* (\r\f\036\b \030\026\027\036\027\017\005 \032\017\r\024\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\026 [1]. \212\026\027\027\t\005 \235\026\022\021 \024\002\031\f\ \035\024\r)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.228 Tw T* (\035\036\027 \027\036 \021\024\035\034\022\024 \r\t\f\024\022\024\017\027\ \021\036\027\f\017\r\027\t\n \b\026\030\026\022\021\036\030\024\n \002\024\ \036)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.085 Tw T* (\f\021\024\035\022\027\024\r\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \r\024\024\030\031\032\036\027\027\t\b\ \022\024\027\235\035\017\022)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc -0.001 Tw T* (\021\026\b, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\036\n \007\024\035\017 \021\016\032\036\035\ \t\b \017)Tj /Span<>> BDC ( )Tj EMC 15.575 0 Td [(\022\030\026\005\027\036 \021\016\032\036\035\t\b)-10( )]TJ 0.128 Tw -15.575 -1.218 Td (\023\024\r\030\036\032\007\036\027\017\005 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \031\r\036\035\017\004\036\027\017\016 \022\024\035\017\004\ \036\f\021\r\026 \n\027\024\032\036)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.123 Tw T* [(\f\021\r\036\027\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.959 0 Td [(\f\024\004\036\021\026\027\027\t\b )0.5(\030\026\027\036\027\017\005 )0.5([2]. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.588 0 Td [(\220\021\024\n )0.5(\n\036\007\017)]TJ 0 Tc 0 Tw (-)Tj -0.01 Tc 0.019 Tw -17.547 -1.218 Td [(\006\017\027\f\022\017\036 )0.5(\f\023\036\006\017\026\035\017\f\021\t, )0.5(\027\036\023\024\f\030\036\007\f\021\r\036\027\027\024 )0.5(\024\022\026\t\r\026\033\013\017\036)-10( )]TJ 0.193 Tw T* (\023\024\n\024\013\034 \030\026\027\036\027\t\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b \220\021\026\023\026\b \n\036\007\017\006\017\ \027\f\022\024\005)-10( )]TJ 0.228 Tw T* (\220\r\026\022\031\026\006\017\017 \(\233\204\233\), \f\021\026\035\022\017\ \r\026\033\021\f\016 \027\036 \021\024\035\034\022\024 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\031\007\027\024)Tj 0 Tc 0 Tw (-)Tj -0.01 Tc 0.047 Tw T* (\f\021\016\n\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\005 \007\017\026\020\027\024\f\021\017\022\036 \200\ \002\217\215\025, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC [(\f \023\030\024\002\035\036\n\024\005)-10( )]TJ 0.1 Tw T* [(\024\021\f\031\021\f\021\r\017\016 )0.5(\036\007\017\027\024\020\024 )0.5(\023\024\007\b\024\007\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 12.696 0 Td [(\b\017\030\031\030\020\017\004\036\f\022\024\005 )0.5(\021\026\022\021\017\022\036)-10( )]TJ 0 Tw -12.696 -1.218 Td (\035\036\004\036\027\017\016 \007\026\027\027\024\005 \022\026\021\036\020\ \024\030\017\017 \023\024\f\021\030\026\007\026\r\001\017\b [3].)Tj -0.006 Tc 0.343 Tw T* (\025\024\027\006\036\023\006\017\016 \b\017\030\031\030\020\017\004\036\f\ \022\024\005 \023\024\n\024\013\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\r\024\024\030\031\032\036\027\027\t\b)-6( )]TJ 0.169 Tw T* (\022\024\027\235\035\017\022\021\026\b \023\030\036\007\031\f\n\026\021\030\ \017\r\026\036\021 \023\030\036\036\n\f\021\r\036\027\027\024\f\021\034 \ \007\017\026\020)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.098 Tw T* [(\027\024\f\021\017\004\036\f\022\017\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 6.238 0 Td [(\035\036\004\036\002\027\024-\220\r\026\022\031\026\006\017\024\027\027\t\ \b )0.5(\n\036\030\024\023\030\017\016\021\017\005,)-6( )]TJ 0.356 Tw -6.238 -1.218 Td (\r\t\023\024\035\027\016\036\n\t\b \023\024\f\035\036\007\024\r\026\021\036\ \035\034\027\024 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\027\t\b \031\030\024\r\027\016\b)-6( )]TJ 0.039 Tw T* (\024\022\026\026\027\017\016 \n\036\007\017\006\017\027\f\022\024\005 \023\ \024\n\024\013\017 \(\211\204\215\) \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n \n\036\007\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.04 Tw T* (\022\024-\021\026\022\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\ \024\r\022\017. \003\026\022\024\027\024\n\036\030\027\t\n \f\035\036\007\ \f\021\r\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.264 Tw T* [(\036\n \220\r\024\035\033\006\017\017 \035\036\004\036\002\027\024-\220\r\ \026\022\031\026\006\017\024\027\027\t\b \n\036\030\024\023\030\017\016\021\ \017\005,)-6( )]TJ 0.28 Tw 23.244 31.663 Td (\r\024 \n\027\024\020\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\f\031\013\036\f\021\r\036\027\027\t\n\017 \017\n\036\027\036\027\017\016\ \n\017)-6( )]TJ 0.302 Tw T* (\b\026\030\026\022\021\036\030\026 \002\024\036\r\t\b \007\036\005\f\021\ \r\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \r\024\024\030\031)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.018 Tw T* [(\032\036\027\027\t\b )0.5(\022\024\027\235\035\017\022\021\026\b, )0.5(\f\021\026\035\024 )0.6(\f\024\024\021\r\036\021\f\021\r\017\036 )0.5(\022\026\032\007\024\n\031 )0.5(\233\204\233)-6( )]TJ 0.316 Tw T* (\024\023\030\036\007\036\035\036\027\027\024\020\024 \211\204\215. \215\030\ \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026)Tj /Span<>> BDC ( )Tj EMC [(\023\036\030\036\007\024\r\t\b \233\204\233,)-6( )]TJ -0.039 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.655 0 Td [(\r\017\007\031 )0.5(\024\020\030\026\027\017\004\036\027\027\024\f\021\017 )0.5(\030\036\f\031\030\f\024\r )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.46 0 Td [(\030\026\f\023\024\035\024\032\036\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.775 0 Td (\024\021)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.051 Tw -20.89 -1.218 Td (\027\024\f\017\021\036\035\034\027\024\005 \002\035\017\024\f\021\017 \022\ )Tj /Span<>> BDC ( )Tj EMC (\035\017\027\017\017 \002\024\036\r\024\020\024 \f\024\023\030\017\022\024\ \f\027\024\r\036)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc 0.143 Tw T* [(\027\017\016, \r\t\023\024\035\027\017\021\034 \007\024\f\021\026\021\024\ \004\027\t\005 \024\002\255\036\n \007\017\026\020\027\024\f\021\017\004\ \036\f\022\017\b)-6( )]TJ 0.03 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\002\027\t\b \n\036\030\024\023\030\017\016\021\017\005 \ \026\004\026\f\021\031\033 \027\036 \023\030\036\007\f\021\026\r\035\016\ \036\021\f\016)-6( )]TJ 0.085 Tw T* (\r\024\n\024\032\027\t\n [2,4]. \212\026\027\027\024\036 \024\002\f\021\ \024\016\021\036\035\034\f\021\r\024 \024\002\031\f\035\024\r\035\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc -0.005 Tw T* (\r\026\036\021 \023\024\007\027\036\036 \r\t\016\r\035\036\027\017\036 \ \200\002\217\215\025 \031)Tj /Span<>> BDC ( )Tj EMC (91,9% \030\026\027\036\027\t\b, \023\030\017)Tj 0 Tc 0 Tw (-)Tj -0.006 Tc T* (\004\036\n \021\030\036\021\034 \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \r\t\016\r\035\016\036\021\f\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (5 \211\204\215 [1,5,6].)Tj -0.016 Tc 0.275 Tw T* [(\221\026\022\017\n \024\002\030\026\024\n, \026\022\021\031\026\035\034\ \027\024\f\021\034 \023\030\024\002\035\036\n\t \007\017\026\020\027\024\ \f\021\017\022\017)-16( )]TJ -0.022 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036\004\036\027\ \017\016 \200\002\217\215\025 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \f\024\r\030\036\n\036\027)Tj 0 Tc 0 Tw (-)Tj -0.016 Tc 0.016 Tw T* [(\027\t\b )0.5(\r\024\024\030\031\032\036\027\027\t\b )0.5(\022\024\027\235\035\017\022\021\024\r )0.5(\023\030\024\007\017\022\021\024\r\026\027\026, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.126 0 Td [(\023\036\030\r\031\033)-16( )]TJ 0.107 Tw -19.126 -1.218 Td (\024\004\036\030\036\007\034, \n\027\024\020\024\020\030\026\027\027\024\ \f\021\034\033 \007\036\005\f\021\r\031\033\013\036\020\024 \r)Tj /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036)-16( )]TJ 0.128 Tw T* [(\r\030\036\n\016 \022\024\027\006\036\023\021\031\026\035\034\027\024\020\ \024 \023\024\007\b\024\007\026, \024\021\f\031\021\f\021\r\017\036\n \036\ \007\017\027\024\020\024)-16( )]TJ 0.027 Tw T* (\023\024\027\017\n\026\027\017\016 \b\017\030\031\030\020\017\004\036\f\022\ \024\005 \021\026\022\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\024\r\026\021\036\035\034\027\024)Tj 0 Tc 0 Tw (-)Tj -0.016 Tc 0.133 Tw T* (\f\021\017 \036\036 \030\036\026\035\017\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\030\026\035\017\004\027\t\b \211\204\215. \222\031\013\036\f\021\r\031\ \033\013\026\016)-16( )]TJ 0.238 Tw T* (\030\026\027\024\030\024\007\027\024\f\021\034 \023\024\007\b\024\007\024\ \r \022)Tj /Span<>> BDC ( )Tj EMC [(\035\036\004\036\027\017\033 \200\002\217\215\025 \016\r\035\016\036\021\ \f\016)-16( )]TJ -0.016 Tw T* [(\023\030\036\007\017\022\021\024\030\024\n )0.5(\007\024\f\021\026\021\024\004\027\024 )0.5(\r\t\f\024\022\024\005 )0.5(\004\026\f\021\024\021\t )0.5(\030\026\r\017\021\017\016 )0.5(\024\f)]TJ 0 Tc 0 Tw (-)Tj -0.016 Tc -0.072 Tw T* (\035\024\032\027\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\035\036\021\026\035\034\027\024\f\021\017 \031)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\005 \022\026\021\036\020\024\030\017\017 \023\026\006\ \017\036\027\021\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 115.9299 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.455 Tw 10 0 0 10 303.3071 91.5739 Tm [(\210\006\036\027\017\021\034 )0.5(\023\030\017\r\036\030\032\036\027\027\024\f\021\034 )0.5(\023\030\026\022\021\017\022\031\033\013\017\b )0.6(\b\017\030\031\030\020\024\r )]TJ 0.058 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\n \n\036\021\024\007\026\n \007\017\026\020\027\ \024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 20.7653 56.0378 Tm (102)Tj ET endstream endobj 957 0 obj [964 0 R] endobj 958 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022\024\t\025\013)10.1(\025)21(\237\026)11(\017\224\t\025\013)10(\025 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 )]TJ 0 -1 TD [(\020\004\225\004\t\n\213 \224\017\n\004\t\026)11(\025\b \016\022\b\t\004\255\005\206\204\n\t\t\217\024\n \005\017\t\004\t\ \n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)]TJ 37.985 1 Td [(Contr)20(ov)12(er)20(sial issues of\022diagnosis and multi-stage sur)31(gical )]TJ 0.588 -1 Td [(tr)31(eatment in\022patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 285.4104 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 285.4104 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 248.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 248.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-101-115)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 79.1689 695.3259 Tm [(\001\224\025\005\t\217\004 \b\025\224\005\025\016\217 \202\n\017\013\t\025\ \016)-9.9(\026\n\r\n \n\022)-23.3(\024\t\025\013)10(\025)21(\237\026)11(\017\224\t\025\013)10(\025 )]TJ -1.329 -1.105 Td [(\220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \224\017\n\004\t\026)11.1(\025\b \016\022)-23.3(\b\t\004\255\005\206\204\n\t\t\217\024\n )]TJ 5.976 -1.105 Td (\005\017\t\004\t\n\213\024\n \224\005\213\024\025\221 \r\n\204\r\n)Tj 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 628.822 Tm [(\001\002\005\025\b\022)-23.3(\201.\f)-30.9(.)]TJ 8.162 0 0 8.162 108.337 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 112.9729 628.822 Tm [(, \240\016\004\020\004\b\n\225\022)-23.2(\033)124(.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 196.616 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 207.9366 628.822 Tm [(, \f)-21(\020\n\024\025\b\022)-23.2(\034.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 290.2913 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 294.9272 628.822 Tm [(, \006\017\020\206\005\017\022)-23.2(\036.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 378.0663 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 389.3869 628.822 Tm [(, \033)-21(\002\024\213\t\004\b\022)-23.2(\021.\007.)]TJ 0 Tw 8.162 0 0 8.162 479.1757 633.484 Tm (1)Tj 14 0 0 14 483.8116 628.822 Tm (, )Tj -31.521 -1.143 Td [(\006\017\005\202\017\r)10(\025\b\022)-23.2(\001.\007.)]TJ 8.162 0 0 8.162 127.0269 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 131.6628 612.822 Tm [(, \203\025\026)11(\025\b\022)-23.2(\037.\207.)]TJ 0 Tw 8.162 0 0 8.162 206.4723 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 211.1083 612.822 Tm [(, \036\b)21(\225\n\t\t\n\r)10.1(\025\b\022)-23.3(\201.\021.)]TJ 0 Tw 8.162 0 0 8.162 317.3048 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 321.9407 612.822 Tm [(, \201\217\024\t\n\r)10.1(\025\b\022)-23.3(\201.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 418.4212 617.484 Tm (1)Tj 14 0 0 14 423.0572 612.822 Tm (, )Tj -27.181 -1.143 Td [(\037)31(\025\005\226\002\r\022)-23.3(\235.\001.)]TJ 8.162 0 0 8.162 118.0532 601.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 582.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 579.1527 Tm [(\210\031\006\021\036)20(\227 \021\036 \253\021\025\004\t\t\025-\024\004\202\n\n\t\016\r\017\213\ \017\r\017\202\004\024\n\213 \n\024.\022)-23.3(\001.\235.\022)-23.3(\037)20(\n\005\025\b\017\273 \(\002\020.\022)-23.3(\f\r\017\202\004\024\n\r\017 \035\004\255\004\202\004\b\017, \202.\022)-23.3(6\223, \013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-)]TJ -0.331 -1.2 Td [(\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)80(40)25(44, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 558.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 555.1527 Tm [(\215\036)20(\227\021\036 \253\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)10.1(\016\r\n\221 \024\004\202\n\r)10(\025-\016\025\n\017\020\200\t\217\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026\273 \(\224\005-)-41.9(\026 \037)31(\025\t\202\005\017\026\200\004\b\016\r\n\221, \202.\022)-23.3(7)58(2, \020\n\026)11(\004\005 \f)-52(, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\001\017\t\r)-9.9(\026)-42(-\034\004\026)11(\004\005\255\002\005\013)41(, 1)138(9)46(5)35(2)46(7)127(1)69(, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0 Tw 9 0 0 9 90.7087 524.6488 Tm (\037\036\035\034: \031\006\027\025\022\023\017 \033\032\022\021\027\032\255\ \027\025\025\031\024\023\017 \033\032\020\n\023\022\n\r\005\212\022\200 \ \200\022\032\r\032\b\031\021 \n)Tj /Span<>> BDC ( )Tj EMC (\026\027\023\031\030\020\026 \030\022\020\b\025\031\024\023\022\n\022 \022\ )Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\031\b\031 \f\027\007\027\025\022\t\ )Tj 0.148 Tw 0 -1.111 TD [(\033\031\024\023\032\020\030\020\021\213\022\200 )0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\021\025\027\240\032\005\213\022\025\025\013\026\022 \032\020\025\027\025\ \022\t\026\022 \033\032\t\026\031\235 )0.5(\n\022\213\n\022 \025\020)]TJ /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \r\032\031\021\025\t\200 \031\n\020\016\ \020\025\022\t \026\027\030\022\006\022\025\024\n\031\235 )Tj 0.023 Tw T* (\033\031\026\031\212\022 \(\210\215\004\).)Tj 0.026 Tw T* (\215\003\036\206\002\003\035\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\031\n\023\t\240\032\027 2024 \b\031\030\020 \033\032\031\021\027\030\027\ \025\031 \031\240\024\027\032\021\020\006\022\031\025\025\031\027 \033\031\ \033\027\032\027\007\025\031\027 \022\024\024\f\027\030\031\021\020\025\022\ \027 \026\027\023\031\030\031\021 )Tj 0.018 Tw T* (\030\022\020\b\025\031\024\023\022\n\022 \022)Tj /Span<>> BDC ( )Tj EMC (\200\022\032\r\032\b\022\007\027\024\n\031\235 \023\020\n\023\022\n\022 \ \f\027\007\027\025\022\t \033\031\024\023\032\020\030\020\021\213\022\200\ \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\240\032\005\213\022\025\025\013\026\022 \032\020\025\027\025\ \022\t\026\022 \033\032\t\026\031\235 \n\022\213\n\022 )Tj 0.126 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\031\021\020\025\022\027\026 \020\025\031\025\022\ \026\025\031\b\031 \031\033\032\031\024\025\022\n\020 \021)Tj /Span<>> BDC ( )Tj EMC (\021\022\030\027 \031\025\f\020\235\025-\203\031\032\026\013, \021)Tj /Span<>> BDC ( )Tj EMC (\n\031\023\031\032\031\026 \033\032\022\025\t\f\022 \r\007\020\024\023\022\ \027 75 \200\022\032\r\032\b\031\021. )Tj 0.027 Tw T* (\206\027\024\033\031\025\030\027\025\023\013 \240\013\f\022 \032\020\024\ \033\032\027\030\027\f\027\025\013 \025\020)Tj /Span<>> BDC ( )Tj EMC (\007\027\023\013\032\027 \b\032\r\033\033\013 \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \200\020\032\020\n\ \023\027\032\022\024\023\022\n \204\023\020\033\020 \026\027\030\022\006\ \022\025\024\n\031\235 )Tj 0.151 Tw T* (\204\021\020\n\r\020\006\022\022 \(\230\215\230\). \202\032\022\023\027\032\ \022\022 \021\n\f\005\007\027\025\022\t: \200\022\032\r\032\b-\032\027\024\ \033\031\025\030\027\025\023 \030\031\f\255\027\025 \022\026\027\023\017\ \031\033\013\023 \031\n\020\016\020\025\022\t \200\022\032\r\032\b\022\007\ \027\024\n\031\235 )Tj 0.042 Tw 0 -1.111 TD (\033\031\026\031\212\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\026 \022\016)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\027\007\022\024\f\027\025\025\013\200 \210\215\004. \202\032\ \022\023\027\032\022\022 \022\024\n\f\005\007\027\025\022\t: \031\023\024\ \r\023\024\023\021\022\027 \r)Tj /Span<>> BDC ( )Tj EMC (\032\027\024\033\031\025\030\027\025\023\020 \031\033\013\023\020 \031\n\ \020\016\020)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\025\022\t \200\022\032\r\032\b\022\007\027\024\n\031\235 \033\031\026\031\ \212\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\033\027\032\027\007\022\024\f\027\025\025\013\200 \210\215\004.)Tj 0.235 Tw T* (\206\036\207\210\035\034\003\201: \031\033\032\031\024 \200\022\032\r\032\ \b\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\200 \210\215\004 \021\013\t\021\022\f \031\ \023\024\r\023\024\023\021\022\027 \022\f\022 \025\022\016\n\r\005 \021\025\ \r\023\032\027\025\025\005\005 \024\031\b\f\020\024\031)Tj 0 Tw (-)Tj 0.306 Tw T* (\021\020\025\025\031\024\023\017 \021)Tj /Span<>> BDC ( )Tj EMC (\240\031\f\017\213\022\025\024\023\021\027 \031\023\021\027\023\031\021 \ \032\027\024\033\031\025\030\027\025\023\031\021 \025\020)Tj /Span<>> BDC ( )Tj EMC (\n\020\255\030\031\026 \230\215\230. \205\032\027\030\025\t\t \024\023\027\ \033\027\025\017 \024\031\b\f\020\024\031\021\020\025\025\031\024\023\022\ )Tj 0.101 Tw T* (\030\031\024\023\022\b\025\r\023\020 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\031\023\021\027\023\027 \025\020)Tj /Span<>> BDC ( )Tj EMC (\021\031\033\032\031\024\013 \031)Tj /Span<>> BDC ( )Tj EMC (\024\033\031\024\031\240\027 \022)Tj /Span<>> BDC ( )Tj EMC (\006\027\f\t\200 \021\013\033\031\f\025\027\025\022\t \032\r\023\022\025\ \025\031\b\031 \030\032\027\025\022\032\031\021\020\025\022\t \n\f\027\023\ \007\020\023\031\007)Tj 0 Tw (-)Tj 0.134 Tw T* [(\025\013\200 )0.6(\033\032\031\024\023\032\020\025\024\023\021 )0.6(\023\020\016\020. )0.6(\211)]TJ /Span<>> BDC ( )Tj EMC 11.551 0 Td [(\031\023\021\027\023\020\200 )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC 5.439 0 Td [(\021\031\033\032\031\024 )0.6(\031)]TJ /Span<>> BDC ( )Tj EMC 4.013 0 Td [(\033\031\024\f\027\030\031\021\020\023\027\f\017\025\031\024\023\022 )0.6(\021\013\033\031\f\025\027\025\022\t )0.5(\031\033\027\032\020\023\022\021\025\013\200 )0.6(\033\032\022\027\026\031\021 )]TJ 0.008 Tw -21.002 -1.111 Td (\033\032\022)Tj /Span<>> BDC ( )Tj EMC 1.717 0 Td [(\204\n\024\023\032\020\033\027\032\022\023\031\025\027\020\f\017\025\013\ \200 )0.7(\033\031\021\032\027\255\030\027\025\022\t\200 )0.5(\033\032\t\026\031\235 )0.6(\n\022\213\n\022 )0.5(\n\031\204\203\203\022\006\022\027\025\023 )0.5(\003\2051 )0.5(\216\021\027\023\020 )0.5(\033\032\022\240\f\022\255\020\027\023\024\t )0.5(\n)]TJ /Span<>> BDC ( )Tj EMC 40.064 0 Td (\024\032\027\030\025\027\235 )Tj 0.023 Tw -41.781 -1.111 Td (\024\023\027\033\027\025\022 \024\031\b\f\020\024\031\021\020\025\025\031\ \024\023\022 \(0,383 \(95% \030\031\021\027\032\022\023\027\f\017\025\013\ \235 \022\025\023\027\032\021\020\f: 0,119; 0,647\)\).)Tj 0.25 Tw T* (\207\003\202\035\224\232\036\001\002\036: \031\030\025\022\026 \022\016)Tj /Span<>> BDC ( )Tj EMC (\021\020\032\022\020\025\023\031\021 \203\031\032\026\022\032\031\021\020\ \025\022\t \027\030\022\025\031\b\031 \033\031\030\200\031\030\020 \n)Tj /Span<>> BDC ( )Tj EMC (\031\n\020\016\020\025\022\005 \200\022\032\r\032\b\022\007\027\024\n\031\ \235 \033\031\026\031\212\022 )Tj -0.041 Tw 0 -1.111 TD (\033\032\022)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\240\032\005\213\022\025\025\013\200 \032\020\025\027\025\022\ \t\200 \033\032\t\026\031\235 \n\022\213\n\022 \t\021\f\t\027\023\024\t \ \033\032\031\021\027\030\027\025\022\027 \022\024\024\f\027\030\031\021\020\ \025\022\t \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\022\026\027\025\027\025\022\027\026 \220\027\f\017\203\022\235\024\ \n\031\b\031 )Tj 0.004 Tw 0 -1.111 TD [(\026\027\023\031\030\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 4.165 0 Td [(\033\032\022\021\f\027\007\027\025\022\027\026 )0.6(\b\032\r\033\033\013 )0.6(\204\n\024\033\027\032\023\031\021, )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 14.633 0 Td [(\033\031\024\f\027\030\r\005\212\027\235 )0.6(\032\020\016\032\020\240\031\023\n\031\235 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 12.217 0 Td [(\021\025\027\030\032\027\025\022\027\026 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 5.783 0 Td [(\033\032\020\n\023\022\n\r )0.6(\025\020)]TJ /Span<>> BDC ( )Tj EMC 5.475 0 Td (\031\024\025\031\021\027 )Tj 0.023 Tw -42.272 -1.111 Td (\n\031\025\024\027\025\024\r\024\025\031\b\031 \032\027\213\027\025\022\t\ \020\f\b\031\032\022\023\026\031\021 \f\027\007\027\025\022\t \030\020\025\ \025\031\b\031 \021\022\030\020 \032\020\025\027\025\022\235 \025\020)Tj /Span<>> BDC ( )Tj EMC (\230\215\230.)Tj /T1_2 1 Tf 0.01 Tc 0.1 Tw 8 0 0 8 42.5596 319.3796 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.105 Tw 8.575 0 Td ( \021\025\027\240\032\005\213\022\025\025\013\027 \033\031\021\032\027\255\ \030\027\025\022\t \033\032\t\026\031\235 \n\022\213\n\022, 4D-\n\031\025\ \006\027\033\006\022\t, \n\031\025\023\032\031\f\017 \033\031\021\032\027\ \255\030\027\025\022\235, \026\025\031\b\031\204\023\020\033\025\031\027\ \200\022\032\r\032\b\022\007\027\024\n\031\027 )Tj 0.023 Tw -8.58 -1.2 Td (\f\027\007\027\025\022\027, \031\b\025\027\024\023\032\027\f\017\025\013\ \027 \032\020\025\027\025\022\t, \033\020\032\020\032\027\n\023\020\f\017\ \025\031\027 \030\032\027\025\022\032\031\021\020\025\022\027, \204\023\020\ \033\013 \026\027\030\022\006\022\025\024\n\031\235 \204\021\020\n\r\020\ \006\022\022)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.024 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5.2( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.014 Tc -0.035 Tw 8.982 0 Td ( \222\031\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \213\f\036\035\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\217.\200., \202\035\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\202., \207\026\035\033\030\026)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \217\031\n\016\027\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\200.\203., \207\026\030\007\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\203., \003\024\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\025.\224., \210\r\004\017\027\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\212.\200.,)14( )]TJ 0.021 Tc -8.987 -1.2 Td (\212\t\n\027\017\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \025\024\030\032\031\022)Tj /Span<>> BDC ( )Tj EMC (\204.\222. \222\023\024\030\027\t\036 \r\024\023\030\024\f\t \007\017\026\ \020\027\024\f\021\017\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\220\021\026\023\027\024\020\024 \b\017\030\031\030\020\ \017\004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \023\026\006\ \017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC [(\r\027\036\002\030\033\001\017\027\027\t\n\017)21( )]TJ 0.02 Tc -0.034 Tw 0 -1.2 TD [(\030\026\027\036\027\017\016\n\017 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017. )]TJ /T1_1 1 Tf -0.02 Tw 11.605 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.034 Tw [( )0.6(2026; )0.6(\021.)]TJ /Span<>> BDC ( )Tj EMC 11.854 0 Td [(25, )0.5(\223)]TJ /Span<>> BDC ( )Tj EMC 2.543 0 Td [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC 1.937 0 Td [(101\226115. )0.6(https://doi.org/10.33878/2073-7556-2026-25-1-101-115)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 65.6456 222.0332 Tm [(Contr)20(ov)12(er)20(sial issues of\022)-23.3(diagnosis and multi-stage sur)31(gical )]TJ 0.294 -1.167 Td [(tr)31(eatment in\022)-23.3(patients with e)21(xtr)21(aperitoneal r)31(ectal w)11(ounds)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 176.5293 Tm [(Dmitrii\022)-23.2(A)-31(.\022)-23.3(Sur)20(ov)]TJ 8.162 0 0 8.162 131.1041 181.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 135.74 176.5293 Tm [(, Roman\022)-23.2(V)62(.\022)-23.3(Esele)11(vich)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 251.5308 181.1913 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 262.8514 176.5293 Tm [(, P)20(av)12(el\022)-23.3(A)-30.9(.\022)-23.3(Alimov)]TJ 0 Tw 8.162 0 0 8.162 359.9802 181.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 364.6162 176.5293 Tm [(, Oleg\022)-23.2(V)62(.\022)-23.3(Balur)21(a)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 455.6969 181.1913 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 14 0 0 14 467.0175 176.5293 Tm (, )Tj -30.321 -1.143 Td [(V)31(aler)-31(y\022)-23.2(N.\022)-23.3(Rum)21(y)21(antse)11(v)]TJ 8.162 0 0 8.162 166.4822 165.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 171.1181 160.5293 Tm [(, Ser)31(gey\022)-23.2(N.\022)-23.3(Bar)31(dak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 292.9991 165.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 297.635 160.5293 Tm [(, K)41(onstantin\022)-23.2(Y)40(u.\022)-23.3(Z)21(otov)]TJ 0 Tw 8.162 0 0 8.162 419.9073 165.1913 Tm (1)Tj 14 0 0 14 424.5432 160.5293 Tm (, )Tj -27.287 -1.143 Td [(Dmitrii\022)-23.2(V)62(.\022)-23.3(Obchinnik)11.1(ov)]TJ 8.162 0 0 8.162 167.6434 149.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 172.2794 144.5293 Tm [(, Denis\022)-23.2(A)-31(.\022)-23.3(Dymnik)11.1(ov)]TJ 0 Tw 8.162 0 0 8.162 286.5857 149.1913 Tm (1)Tj 0.023 Tw 14 0 0 14 291.2216 144.5293 Tm [(, Mikhail\022)-23.2(S.\022)-23.3(K)41(or)20(zh)11(uk)]TJ 0 Tw 8.162 0 0 8.162 404.6322 149.1913 Tm (1)Tj 5.83 0 0 5.83 42.5197 130.19 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 126.86 Tm [(S.M.\022)-23.3(Kir)20(ov Militar)-30.9(y Medical Academ)21(y \(Akademika Lebede)11(v)10(a\022)-23.2(st., 6J, Saint P)10(eter)20(sbur)31(g, 1)138(9)79.9(40)25.1(44,Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 118.19 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 114.86 Tm [(St. P)10(eter)20.1(sbur)31(g Medical and social institute \(K)41(ondr)21.1(atie)11(v)10(sky A)20(v)12(e., 7)58.1(2, let)-20(ter A)-30.9(, St. P)10(eter)20(sbur)31(g, 1)138(9)46(5)35(2)46(7)127(1)69(, Russia\))]TJ /T1_1 1 Tf 0.057 Tw 9 0 0 9 90.7087 96.3561 Tm [(AIM: to )0.5(assess the )0.5(adherence of )0.5(surg)12(eons to v)16(ar)-36.9(ious methods )0.5(of diagnosis and surgical treatment of )0.5(patients with )]TJ 0.023 Tw 0 -1.111 TD 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Col)29.6(or)-24.4(ec)-16.4(t)14.6(al anast)16.6(omo)16.5(t)-32.4(ic leak)]TJ 0 Tc 0 Tw 25.986 0 Td (-)Tj 0.195 Tw -27.286 -1.25 Td [(a)-17(ge: a)]TJ /Span<>> BDC ( )Tj EMC [(nar)-24(r)-33(a)15(t)-31.9(i)-16(ve r)-24(ev)-16(iew of)]TJ /Span<>> BDC ( )Tj EMC [(def)-27.9(ini)-24(t)-32(ions, gr)-33(ading sy)-13(stems, and con)]TJ 0 Tw (-)Tj 0.27 Tw T* (sequences of)Tj /Span<>> BDC ( )Tj EMC [(leak)-10(s. )]TJ /T1_1 1 Tf [(F)27(ront Surg)]TJ /T1_0 1 Tf [(. 2024;11:1371567. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3389/)Tj T* [(fsur)-32(g.2024.1371567)]TJ 0 0 0 1 k /GS1 gs -0.039 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Almut)15.1(air)-37(i)]TJ /Span<>> BDC ( )Tj EMC [(FM. R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(Biomar)-23.9(k)10(er)-10(s in t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Dia)-17(gnosis of)]TJ /Span<>> BDC ( )Tj EMC [(Anast)17.1(omo)17(t)-32(ic )]TJ 0.194 Tw -1.796 -1.25 Td [(L)35(eak)-17(a)-17(ge Af)-27.9(ter Col)30(or)-24(ec)-16(t)15.1(al Sur)-32(ger)-24(y: A)]TJ /Span<>> BDC ( )Tj EMC [(Sy)-13(stema)15(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-)]TJ 0 Tw T* [(Anal)35(y)-13(sis. )]TJ /T1_1 1 Tf 3.827 0 Td (Cureus)Tj /T1_0 1 Tf 0.023 Tw [(. 2024;16\(6\):e62432. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.62432)]TJ 0 0 0 1 k /GS1 gs 0.304 Tw -3.827 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(S)15(tum)10(pf)]TJ /Span<>> BDC ( )Tj EMC 3.383 0 Td [(M, )0.5(Kl)-31(inge)]TJ /Span<>> BDC ( )Tj EMC [(U, )0.5(W)-16(ilms)]TJ /Span<>> BDC ( )Tj EMC 8.718 0 Td [(A, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(Changes )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he )0.5(e)-18(xtr)-32.9(a)]TJ 0 Tw (-)Tj 0.009 Tc 0.349 Tw -13.897 -1.25 Td [(cell)35.3(ul)-15.8(ar ma)15.3(tr)-36.7(ix as a)]TJ /Span<>> BDC ( )Tj EMC [(r)-36.8(isk f)16.2(a)-16.7(c)-15.8(t)17.3(or for anast)17.3(omo)17.2(t)-31.8(ic leak)-16.8(a)-16.7(ge af)-27.7(ter)9( )]TJ 0 Tc 0.109 Tw T* [(l)-16(ar)-32(ge bo)-14(wel sur)-32(ger)-24(y. )]TJ /T1_1 1 Tf 0 Tw [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf 0.109 Tw [(. 2005;137\(2\):229\22634. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* [(sur)-32(g.2004.07.011)]TJ 0 0 0 1 k /GS1 gs 0.051 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ed)-16(omsk)-15.9(is)]TJ /Span<>> BDC ( )Tj EMC [(P, Goudber)-32(g)]TJ /Span<>> BDC ( )Tj EMC [(MR, Sp)32(ar)-24(r)-24(ebo)-16(om)]TJ /Span<>> BDC ( )Tj EMC [(CL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ma)15(tr)-36.9(ix me)-12(t)15(all)30(o)]TJ 0 Tw (-)Tj -0.021 Tw -1.796 -1.25 Td [(p)25(r)-32(o)17(teinase-9 in r)-24(el)-15.9(a)15(t)-32(ion t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)32(a)15(t)-32(ients wi)-23.9(t)-13(h com)10(pl)-31(ica)15.1(t)-32(ions af)-28(ter col)30(or)-24(ec)]TJ 0 Tw (-)Tj 0.068 Tw T* [(t)15(al sur)-31.9(ger)-24(y: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-12.9(stema)15(t)-32(ic r)-23.9(ev)-16(iew. )]TJ /T1_1 1 Tf [(Int J )0.5(Colorectal )0.5(Dis.)]TJ /T1_0 1 Tf ( 2021;36\(1\):1\226)Tj 0.023 Tw T* [(10. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-020-03724-6)Tj 0 0 0 1 k /GS1 gs 0.087 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(L)35(uo)]TJ /Span<>> BDC ( )Tj EMC [(J, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(H, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(Y, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Oxid)42(a)15(t)-32(i)-16(ve S)15.1(tr)-24(ess L)35(evel as a)]TJ /Span<>> BDC ( )Tj EMC [(P)35(r)-24(edic)-16(t)17.1(or )]TJ 0.23 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(Anast)17.1(omo)17(t)-32(ic L)35(eak)-17(a)-17(ge af)-28(ter R)13(ec)-16(t)15(al Sur)-32(ger)-23.9(y. )]TJ /T1_1 1 Tf [(Mediators Inf)-22(lamm.)]TJ /T1_0 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2021;2021:9968642. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1155/2021/9968642)Tj /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 20.7653 56.0378 Tm (100)Tj ET endstream endobj 1000 0 obj <>/Border[0 0 0]/H/N/Rect[190.976 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<>/Border[0 0 0]/H/N/Rect[303.307 688.512 368.595 679.216]/Subtype/Link/Type/Annot>> endobj 1011 0 obj <>/Border[0 0 0]/H/N/Rect[440.523 658.512 514.146 649.056]/Subtype/Link/Type/Annot>> endobj 1012 0 obj <>/Border[0 0 0]/H/N/Rect[489.898 628.512 524.409 619.056]/Subtype/Link/Type/Annot>> endobj 1013 0 obj <>/Border[0 0 0]/H/N/Rect[303.307 618.512 360.443 609.216]/Subtype/Link/Type/Annot>> endobj 1014 0 obj <>/Border[0 0 0]/H/N/Rect[330.503 578.512 427.975 569.216]/Subtype/Link/Type/Annot>> endobj 1015 0 obj <>/Border[0 0 0]/H/N/Rect[387.359 548.512 464.815 539.216]/Subtype/Link/Type/Annot>> endobj 1031 0 obj <> endobj 1030 0 obj <> endobj 1029 0 obj <> endobj 1028 0 obj <> endobj 1027 0 obj <> endobj 1026 0 obj <> endobj 1025 0 obj <> endobj 1024 0 obj <> endobj 1023 0 obj <> endobj 1022 0 obj <> endobj 1021 0 obj <> endobj 1020 0 obj <> endobj 1019 0 obj <> endobj 1018 0 obj <> endobj 1017 0 obj <> endobj 1016 0 obj <> endobj 996 0 obj [1032 0 R 1033 0 R 1034 0 R 1035 0 R 1036 0 R 1037 0 R 1038 0 R 1039 0 R] endobj 997 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 724.8299 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.167 Tw 10 0 0 10 42.5197 700.4739 Tm (\210\023\030\036\007\036\035\036\027\017\036 \031\030\024\r\027\016 \f\r\ \024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\026\ , \204\212\202 )Tj 0.09 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\200\207\212 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\n \023\036\030\017\024\007\036 \n\024\032\036\021 )Tj 0.034 Tw T* (\f\035\031\032\017\021\034 \024\f\027\024\r\024\005 \007\035\016 \023\036\ \030\f\024\027\017\235\017\006\017\030\024\r\026\027\027\024\005 \021\026\ \022\021\017\022\017 )Tj 0.004 Tw T* (\r\036\007\036\027\017\016 \023\026\006\017\036\027\021\024\r \020\030\031\ \023\023\t \r\t\f\024\022\024\020\024 \030\017\f\022\026 \203\202, \r\022\ \035\033)Tj 0 Tw (-)Tj 0.282 Tw T* (\004\026\016 \031\f\017\035\036\027\027\t\005 \n\024\027\017\021\024\030\ \017\027\020, \026\020\030\036\f\f\017\r\027\t\005 \022\024\027\021\030\024\ \035\034 )Tj 0.028 Tw 0 -1.218 TD (\r\027\031\021\030\017\002\030\033\001\027\024\020\024 \007\026\r\035\036\ \027\017\016, \022\024\030\030\036\022\006\017\033 \024\022\f\017\007\026\ \021\017\r\027\024)Tj 0 Tw (-)Tj 0.101 Tw 0 -1.218 TD [(\020\024 )0.5(\f\021\030\036\f\f\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 5.511 0 Td [(\f\r\024\036\r\030\036\n\036\027\027\024\036 )0.6(\r\t\023\024\035\027\036\027\017\036 )0.5(\007\017\026\020\027\024\f\021\017)]TJ 0 Tw (-)Tj -5.511 -1.218 Td (\004\036\f\022\024\005 \017\035\017 \035\036\004\036\002\027\024\005 \030\ \036\035\026\023\026\030\024\021\024\n\017\017.)Tj 0.317 Tw T* [(\200 \n\027\024\020\024\235\026\022\021\024\030\027\024\005 \n\024\007\036\ \035\017 )0.5(\027\036\026\r\017\f\017\n\t\n\017 \023\030\036\007\017\022)]TJ 0 Tw (-)Tj 0.47 Tw T* [(\021\024\030\026\n\017 )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\001\r\024\r )0.5(\021\024\035\f\021\024\022\017\001\036\004\027\024\020\024 )]TJ 0.199 Tw 0 -1.218 TD (\026\027\026\f\021\024\n\024\026 \016\r\035\016\035\017\f\034 \031\030\024\ \r\036\027\034 \f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\ \024)Tj 0 Tw (-)Tj 0.171 Tw 0 -1.218 TD (\035\017\027\026, \r\036\035\017\004\017\027\026 \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\027\021\030\026\006\017\016 \204\212\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 )Tj 0.109 Tw 0 -1.218 TD (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017. \ \025\026\032\007\t\005 \017)Tj /Span<>> BDC ( )Tj EMC (\220\021\017\b \023\024\022\026\026\021\036\035\036\005 )Tj 0.18 Tw 0 -1.218 TD (\007\036\n\024\027\f\021\030\017\030\024\r\026\035 \024\021 \031\n\036\030\ \036\027\027\024\005 \007\024)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\036\005 \007\017\f\022\030\017)Tj 0 Tw (-)Tj 0.09 Tw 0 -1.218 TD (\n\017\027\017\030\031\033\013\036\005 \f\023\024\f\024\002\027\024\f\021\ \017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\b \022\024\n\002\017\027\026\006\017\016 \024\002\036\f\023\036)Tj 0 Tw (-)Tj 0.351 Tw 0 -1.218 TD (\004\017\r\026\035\026 \002\024\035\036\036 \r\t\f\024\022\031\033 \021\024\ \004\027\024\f\021\034 \023\030\024\020\027\024\017\030\024\r\026\027\017\ \016 )Tj 0.201 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \024\021\007\036\035\034\ \027\t\b \n\026\030\022\036)Tj 0 Tw (-)Tj 0.049 Tw 0 -1.218 TD (\030\024\r. \210\022\024\027\004\026\021\036\035\034\027\026\016 \024\006\ \036\027\022\026 \022\035\017\027\017\004\036\f\022\024\005 \027\026\004\ \017\n\024\f\021\017 )Tj 0.092 Tw T* [(\023\030\036\007\035\024\032\036\027\027\t\b )0.6(\023\030\024\020\027\024\f\021\017\004\036\f\022\017\b )0.6(\017\027\007\017\022\026\021\024\030\024\r )0.5(\021\030\036\002\031)]TJ 0 Tw (-)Tj 0.012 Tw 0 -1.218 TD (\036\021 \023\030\024\f\023\036\022\021\017\r\027\024\005 \r\026\035\017\ \007\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \022\030\031\023\027\t\b \027\036\026)Tj 0 Tw (-)Tj 0.158 Tw 0 -1.218 TD (\r\017\f\017\n\t\b \r\t\002\024\030\022\026\b \023\026\006\017\036\027\021\ \024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\020\024 \f\030\026\r\027\036\027\017\016 )Tj 0.043 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\f\031\013\036\f\021\r\031\033\013\017\n\017 )0.5(\002\017\024\n\026\030\022\036\030\027\t\n\017 \017)]TJ /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\030\026\007\017\024)Tj 0 Tw (-)Tj T* (\035\024\020\017\004\036\f\022\017\n\017 \n\024\007\036\035\016\n\017.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_2 1 Tf -0.026 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.8(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf [( \206)-10.5(\r)-4.2(\016)6(\022)1.7(\240)1.2(\031)6(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)29.4(\206)93.8(.)7.9(, )]TJ 0 Tw T* [(\216)98(\r)23.8(\f)3.3(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\215)19.5(.)27.5(\202)8.6(.)7.8(, \216)98(\r)23.8(\f)3.3(\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, \003)-17.3(\f)9.6(\022)-4.3(-)14.4(\207)10.9(\020)0.9(\030)1.9(\027)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)29.3(\216)122(.)]TJ /T1_2 1 Tf 0.4 Tw T* [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.2(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.6(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf [( \206)-10.4(\r)-4.2(\016)6(\022)1.7(\240)1.1(\031)6(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)29.3(\206)93.9(.)7.8(, )]TJ 0 Tw T* [(\216)98(\r)23.8(\f)3.3(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)7.8(, \001)5.9(\r)-4.3(\032)12.2(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\207)27.7(.)20.1(\215)19.4(.)]TJ /T1_2 1 Tf 0.018 Tc -0.018 Tw T* [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 11.349 0 Td [( \003)-17.3(\f)9.6(\022)-4.3(-)14.4(\207)10.9(\020)0.9(\030)1.9(\027 \205)-2.1(.)29.3(\216)92.9(, \216)98(\r)23.8(\f)3.4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)]TJ /T1_2 1 Tf 0.002 Tc -0.002 Tw -11.349 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \206)-10.5(\r)-4.2(\016)6(\022)1.7(\240)1.1(\031)6.1(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC [(\202)8.6(.)29.3(\206)93.9(.)7.8(, \003)-17.2(\f)9.6(\022)-4.3(-)14.3(\207)10.9(\020)0.9(\030)1.9(\027)]TJ /Span<>> BDC ( )Tj EMC [(\205)-2.1(.)29.4(\216)122(.)]TJ /T1_2 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf 0.756 Tw [( )0.5(\206)-10.5(\r)-4.2(\016)6.1(\022)1.7(\240)1.1(\031)6(\235)3.5(\016)2.2(\031\030)4.8(\020)]TJ /Span<>> BDC ( )Tj EMC 14.282 0 Td [(\202)8.6(.)29.3(\206)93.9(.)7.8(, )0.6(\216)98(\r)23.8(\f)3.3(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC 5.888 0 Td [(\215)19.4(.)27.5(\202)8.6(.)7.8(, )]TJ -0.122 Tc 0.122 Tw -20.17 -1.218 Td [(\003)-139.3(\f)-112.4(\022)-126.3(-)-107.6(\207)-111.1(\020)-121.1(\030)-120.1(\027)]TJ /Span<>> BDC 3.678 0 Td ( )Tj EMC [(\205)-124.1(.)-92.7(\216.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -3.678 -2.436 Td (AUTHOR CONTRIBUTIONS)Tj /T1_2 1 Tf -0.083 Tw T* [(S)7(t)-12.8(ud)-10.9(y c)3.7(o)0.8(nce)-0.7(p)-12.3(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n)15.4(:)]TJ /T1_4 1 Tf [( K)12.8(a)2.3(h)6.2(r)7.7(a)-0.8(m)-1.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.4(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.6(z)-17.4(i)9.1(b)-5.9(o)2.3(y)-2.4(z)12.4(o)-7.8(d)1.9(a)-14(, )]TJ 1.231 Tw T* [(M)5.2(a)2.2(h)5.2(m)4.3(a)-4.5(d)-1.4(s)9.6(h)1.9(o)3.2(h)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)2.9(o)-0.6(v)33.6(, A)17.1(f)-23.8(z)12.9(al)-28.6(s)9.6(h)1.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)3(o)-0.6(v)33.6(, )]TJ -0.006 Tc 0.006 Tw T* [(S)9.8(u)-1.4(k)-0.7(hr)-3.5(o)-4(b)]TJ /Span<>> BDC 3.152 0 Td ( )Tj EMC [(G)-7.4(.)]TJ /Span<>> BDC 1.041 0 Td ( )Tj EMC [(A)-2.4(l)-1.7(i)-10.5(-)-3.4(Za)-10.5(d)-7(e)]TJ /T1_2 1 Tf 0 Tc 3.099 Tw 19.051 47.494 Td [(D)-1.6(a)-8.4(t)-27.7(a c)3.7(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g)9(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj 0.903 Tw T* [(K)12.8(a)2.2(h)6.2(r)7.7(a)-0.8(m)-1.1(o)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.6(z)-17.4(i)9.1(b)-5.8(o)2.3(y)-2.5(z)12.4(o)-7.8(d)1.9(a)-14(, A)17.1(f)-23.8(z)12.9(al)-28.6(s)9.6(h)1.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(. G)4.9(u)2.8(l)2.9(o)-0.6(v)33.7(, )]TJ -0.005 Tc 0.005 Tw T* [(Zoi)4.4(r)-15.7(s)4.6(h)-3.1(o)]TJ /Span<>> BDC 2.825 0 Td ( )Tj EMC (M.)Tj /Span<>> BDC 1.172 0 Td ( )Tj EMC [(N)3.6(u)1.1(r)-19.6(z)7.4(o)-12.8(d)-3.1(a)]TJ /T1_2 1 Tf -0.002 Tc -0.035 Tw -3.997 -1.218 Td [(S)5(t)-29.7(a)-10.4(t)-39.4(i)0.7(s)-21.9(t)-39.4(i)3.2(c)-2( ana)-3.5(ly)-21.5(s)-18.6(i)0.7(s:)]TJ /T1_4 1 Tf 0 Tc -0.037 Tw 7.206 0 Td [( S)15.8(u)4.6(k)5.3(h)6.2(r)2.4(o)2(b)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.6(l)4.3(i)-4.6(-)2.6(Z)5.6(a)-4.5(d)-1(e)-20.1(, A)17.1(f)-23.7(z)12.9(al)-28.6(s)9.6(h)1.9(o)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)2.9(o)-0.6(v)]TJ /T1_2 1 Tf -0.009 Tc 0.009 Tw -7.206 -1.218 Td [(W)-5.9(r)-57(i)-15(t)-46.4(i)-1.9(n)-10.9(g:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.318 0 Td [( K)12.8(a)2.2(h)6.2(r)7.8(a)-0.8(m)-1.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.5(z)-17.5(i)9.2(b)-5.9(o)2.3(y)-2.5(z)12.4(o)-7.8(d)1.9(a)-14(, S)15.9(u)4.6(k)5.3(h)6.2(r)2.4(o)2(b)]TJ /Span<>> BDC ( )Tj EMC [(G)-1.4(.)]TJ /Span<>> BDC ( )Tj EMC [(A)3.7(l)4.3(i)-4.6(-)2.6(Z)5.6(a)-4.5(d)-1(e)]TJ /T1_2 1 Tf 0.006 Tc -0.006 Tw -3.318 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc -0.118 Tw 3.238 0 Td [( K)12.8(a)2.2(h)6.2(r)7.7(a)-0.8(m)-1.1(on)]TJ /Span<>> BDC ( )Tj EMC [(R)-2.5(.)]TJ /Span<>> BDC ( )Tj EMC [(R)10.2(u)-1.6(z)-17.4(i)9.1(b)-5.9(o)2.3(y)-2.4(z)12.3(o)-7.7(d)1.9(a)-14(, M)5.2(a)2.2(h)5.2(m)4.3(a)-4.5(d)-1.5(s)9.6(h)1.9(o)3.2(h)]TJ /Span<>> BDC ( )Tj EMC [(K)-13.6(.)]TJ /Span<>> BDC ( )Tj EMC [(G)4.9(u)2.8(l)2.9(o)-0.6(v)33.6(, )]TJ -0.006 Tc 0.006 Tw -3.238 -1.218 Td [(S)9.8(u)-1.4(k)-0.7(hr)-3.5(o)-4(b)]TJ /Span<>> BDC 3.152 0 Td ( )Tj EMC [(G)-7.4(.)]TJ /Span<>> BDC 1.041 0 Td ( )Tj EMC [(A)-2.4(l)-1.7(i)-10.6(-)-3.3(Za)-10.5(d)-7(e)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -4.193 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_2 1 Tf 0.007 Tw T* (\217\031\017\002\024\005\024\007\026 \025\026\b\030\026\n\024\027 \217\ \031\017\002\024\005)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f\f\024\030 )Tj 0.329 Tw T* (\022\026\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b\ \002\024\035\036\027\036\005 \2231 \017\n\036\027\017 \026\022\026)Tj 0 Tw (-)Tj 0.198 Tw T* (\007\036\n\017\022\026 \025.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\031\030\002\024\027\024\r\026, \206\210\211 \253\221\026\007\032\017\ \022\f\022\017\005 \020\024\f\031\007\026\030)Tj 0 Tw (-)Tj 0.173 Tw 0 -1.218 TD (\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\022\017\005 \031\ \027\017\r\036\030\f\017\021\036\021 \017\n\036\027\017 \202\002\031 \026\ \035\017 )Tj 0 Tw 0 -1.218 TD (\017\002\027\017 \222\017\027\024\273; ORCID 0000-0001-8381-0364)Tj 0.083 Tw 0 -1.218 TD (\206\031\035\024\r \204\026\b\n\026\007\001\024\b \025\031\030\002\024\027\ \026\035\017\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024\235\036\f)Tj 0 Tw (-)Tj 0.271 Tw 0 -1.218 TD (\f\024\030 \022\026\235\036\007\030\t \021\024\023\024\020\030\026\235\017\ \004\036\f\022\024\005 \026\027\026\021\024\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026)Tj 0 Tw (-)Tj 0.16 Tw 0 -1.218 TD (\021\017\r\027\024\005 \b\017\030\031\030\020\017\017 \017\n\036\027\017\ \023\030\024\235\036\f\f\024\030\026 \204.\025.)Tj /Span<>> BDC ( )Tj EMC (\025\026\030\017\n\024\r\026 )Tj 0.603 Tw 0 -1.218 TD (\206\210\211 \253\221\026\007\032\017\022\f\022\017\005 \020\024\f\031\007\ \026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\027\f\022\017\005\ )Tj 0.458 Tw 0 -1.218 TD (\031\027\017\r\036\030\f\017\021\036\021 \017\n\036\027\017 \202\002\031\ \026\035\017 \017\002\027\017 \222\017\027\024\273; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0001-5151-937X)Tj -0.029 Tw T* (\206\031\035\024\r \202\235\026\035\001\024 \202\n\017\030\001\024\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \026\024\004\027\t\005 \026\f\023\017\030\026\027\021 \022\026)Tj 0 Tw (-)Tj -0.011 Tw 0 -1.218 TD (\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\ \035\036\027\036\005 \2231 \017\n\036\027\017 \026\022\026\007\036\n\017\ \022\026 )Tj 0.159 Tw 0 -1.218 TD (\025.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\031\030\002\024\027\024\r\026, \206\210\211 \253\221\026\007\032\017\ \022\f\022\017\005 \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \ )Tj -0.049 Tw 0 -1.218 TD (\n\036\007\017\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\ \036\021 \017\n\036\027\017 \202\002\031 \026\035\017 \017\002\027\017 \222\ \017\027\024\273; )Tj 0 Tw T* (ORCID 0009-0002-0859-2939)Tj -0.025 Tw T* (\203\031\030\024\007\026 \003\024\017\030\001\024 \204\017\030\026\b\n\026\ \007)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 \022\026\235\036\007\030\t \ )Tj 0.083 Tw T* (\021\024\023\024\020\030\026\235\017\004\036\f\022\024\005 \026\027\026\021\ \024\n\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\024\005 \b\017\030\031\030\020\017\017\ )Tj 0.076 Tw T* [(\017\n\036\027\017 )0.6(\023\030\024\235\036\f\f\024\030\026 )0.5(\204.\025.)]TJ /Span<>> BDC ( )Tj EMC 10.303 0 Td [(\025\026\030\017\n\024\r\026, )0.5(\206\210\211 )0.6(\253\221\026\007\032\017\022\f\022\017\005 )]TJ 0.36 Tw -10.303 -1.218 Td (\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021 \017\n\036\027\ \017 )Tj 0 Tw T* (\202\002\031 \026\035\017 \017\002\027\017 \222\017\027\024\273; ORCID 0\ 009-0004-8029-9803)Tj 0.193 Tw T* (\202\035\017-\003\026\007\036 \222\031\b\030\024\002 \206\026\235\235\026\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tw (-)Tj -0.011 Tw T* (\235\036\007\030\t \b\017\030\031\030\020\017\004\036\f\022\017\b \002\024\ \035\036\027\036\005 \2231 \017\n\036\027\017 \026\022\026\007\036\n\017\ \022\026 )Tj 0.159 Tw T* (\025.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\031\030\002\024\027\024\r\026, \206\210\211 \253\221\026\007\032\017\ \022\f\022\017\005 \020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \ )Tj -0.049 Tw T* (\n\036\007\017\006\017\027\f\022\017\005 \031\027\017\r\036\030\f\017\021\ \036\021 \017\n\036\027\017 \202\002\031 \026\035\017 \017\002\027\017 \222\ \017\027\024\273; )Tj 0 Tw T* (ORCID 0000-0002-2456-7509)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_2 1 Tf 0 Tw 0 -1.218 TD [(K)-16(ahr)-33(amon R. Ruziboyzod)42.1(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-8381-0364)Tj T* [(Mahmadshoh K. Gul)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-5151-937X)Tj T* [(Afzalsho A. Gul)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0002-0859-2939)Tj T* [(Z)25(oir)-10(sho M. Nur)-23.9(zod)42(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-8029-9803)Tj T* [(Sukhr)-32(ob G. Al)-30.9(i-Z)10(ade)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2456-7509)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 188.9979 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.302 Tw 8 0 0 8 42.5197 176.1632 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Gessler)Tj /Span<>> BDC ( )Tj EMC [(B, Er)-37(ik)-9.9(sson)]TJ /Span<>> BDC ( )Tj EMC [(O, Angene)-12(te)]TJ /Span<>> BDC ( )Tj EMC [(E. Dia)-17(gnosis, tr)-23.9(ea)15(tment, and )]TJ 0.325 Tw -1.296 -1.25 Td (consequences of)Tj /Span<>> BDC ( )Tj EMC [(anast)17.1(omo)17(t)-32(ic leak)-16.9(a)-17(ge in col)30(or)-23.9(ec)-16(t)15(al sur)-31.9(ger)-24(y. )]TJ /T1_4 1 Tf 0 Tw (Int )Tj 0.315 Tw 0 -1.25 TD (J Colorectal Dis. )Tj /T1_2 1 Tf [(2017;32\(4\):549\226556. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-016-)Tj T* (2744-x)Tj 0 0 0 1 k /GS1 gs -0.062 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\214\036\002\036\007\034\022\024)Tj /Span<>> BDC ( )Tj EMC (\204. \222., \206\024\030\007\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\222.\222., \202\035\017\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\233.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \205\026\022\021\024\030\t \030\017\f\022\026 )Tj 0.08 Tw -1.296 -1.25 Td (\030\026\r\017\021\017\016 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \022\024\035\024\030\036\022\021\026\035\034\027\024\020\ \024 \026\027\026\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024)Tj 0 Tw (-)Tj 0.171 Tw T* [(\007\t \036\036 \023\030\024\235\017\035\026\022\021\017\022\017: \030\036\ \021\030\024\f\023\036\022\021\017\r\027\024\036 \022\024\020\024\030\021\ \027\024\036 )0.5(\017\f\f\035\036\007\024\r\026\027\017\036. )]TJ /T1_4 1 Tf 0.052 Tw T* (\020\016\031\021\020\t \200\022\032\r\032\b\022\t \022)Tj /Span<>> BDC ( )Tj EMC (\031\025\n\031\f\031\b\022\t)Tj /T1_2 1 Tf [(. 2022;12\(2\):17\22627. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17650/2)Tj T* (686)Tj /Span<>> BDC (-)Tj EMC (9594)Tj /Span<>> BDC (-)Tj EMC (2022)Tj /Span<>> BDC (-)Tj EMC (12)Tj /Span<>> BDC (-)Tj EMC (2)Tj /Span<>> BDC (-)Tj EMC (17)Tj /Span<>> BDC (-)Tj EMC (27)Tj 0 0 0 1 k /GS1 gs 0.004 Tw [( / L)35(ebedko)]TJ /Span<>> BDC ( )Tj EMC [(M.S., Gor)-24(deev)]TJ /Span<>> BDC ( )Tj EMC [(S.S., Al)-30.9(iev)-15(a)]TJ /Span<>> BDC ( )Tj EMC (E.V., )Tj 0.123 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-24(isk )0.5(f)16(a)-17(c)-16(t)17(or)-10(s for col)30(or)-24(ec)-16(t)15.1(al anast)17(omo)17(t)-32(ic )0.5(leak)-17(a)-17(ge and )0.5(me)-12(t)-13(hods )]TJ 0.154 Tw 29.055 11.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(i)-24(ts p)25(r)-24(event)-31.9(ion: a)]TJ /Span<>> BDC ( )Tj EMC [(r)-24(e)-12(tr)-32(ospec)-16(t)-32(i)-15.9(ve cohor)-22(t stud)17(y. )]TJ /T1_4 1 Tf [(P)15(elvic surg)12.1(er)-43(y and )]TJ 0 Tw T* (oncology)Tj /T1_2 1 Tf 0.099 Tw [(. 2022;12\(2\):17\22627. \(in Russ.\). d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.17650/2686-9594-)Tj T* (2022-12-2-17-27)Tj 0 0 0 1 k /GS1 gs 0.314 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(P)30(eng)16(yu W)22(ei, S)-16(i W)16(u, Jiale Gao, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Def)-28(ini)-24(t)-32(ion and gr)-33(ading )]TJ 0.013 Tc 0.459 Tw -1.296 -1.25 Td [(o)0.5(f)]TJ /Span<>> BDC 0.84 0 Td ( )Tj EMC [(a)0.5(n)0.6(a)0.5(s)0.5(t)17.6(o)0.5(m)0.5(o)17.6(t)-31.5(i)0.6(c)0.5( l)0.5(e)0.6(a)0.5(k)-16.4(a)-16.5(g)0.5(e)0.6( f)0.5(o)0.5(l)0.6(l)30.5(o)-13.5(w)0.6(i)0.5(n)0.6(g)0.5( r)-36.5(i)0.6(g)0.5(h)0.6(t)0.5( h)0.5(e)0.6(m)0.5(i)0.6(c)0.5(o)0.5(l)0.6(e)0.5(c)-15.5(t)17.6(o)0.5(m)0.6(y)0.5(.)0.5( )]TJ /T1_4 1 Tf -0.013 Tw [(B)0.6(J)0.5(S)]TJ /T1_2 1 Tf 0 Tc 0 Tw 26.502 0 Td (. )Tj 0.023 Tw -27.342 -1.25 Td [(2024;111\(7\):155. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1093/bjs/znae155)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.385 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.327 0 Td (Bona)Tj /Span<>> BDC ( )Tj EMC [(D, Danell)-31.3(i)]TJ /Span<>> BDC ( )Tj EMC [(P, S)-16.3(oz)-24.3(zi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12.3(t)]TJ /Span<>> BDC ( )Tj EMC [(al. C-r)-24.3(ea)-17.3(c)-16.3(t)-32.3(i)-16.3(ve P)34.7(r)-32.3(o)16.7(tein and)10( )]TJ 0 Tc 0.226 Tw -1.327 -1.25 Td [(P)35(r)-32(o)-16(cal)16(c)-23.9(i)-24(t)17(onin )0.5(L)35(evels )0.5(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 10.043 0 Td [(P)35(r)-24(edic)-15.9(t )0.5(Anast)17(omo)17(t)-31.9(ic )0.5(L)35(eak )0.5(Af)-27.9(ter )0.5(Col)30.1(or)-24(ec)-16(t)15(al )]TJ 0.135 Tw -10.043 -1.25 Td [(Sur)-32(ger)-23.9(y: Sy)-12.9(stema)15(t)-32(ic R)13(ev)-16(iew and Me)-12(t)15(a-anal)35(y)-13(sis. )]TJ /T1_4 1 Tf (J Gastrointest Surg.)Tj /T1_2 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2023;27\(1\):166\226179. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-022-05473-z)Tj /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8518 56.0378 Tm (99)Tj ET endstream endobj 1032 0 obj <>/Border[0 0 0]/H/N/Rect[192.966 163.459 263.622 154.003]/Subtype/Link/Type/Annot>> endobj 1033 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 153.459 64.8875 144.163]/Subtype/Link/Type/Annot>> endobj 1034 0 obj <>/Border[0 0 0]/H/N/Rect[225.71 113.459 263.622 104.003]/Subtype/Link/Type/Annot>> endobj 1035 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 103.459 131.415 94.1632]/Subtype/Link/Type/Annot>> endobj 1036 0 obj <>/Border[0 0 0]/H/N/Rect[424.519 173.459 496.063 164.003]/Subtype/Link/Type/Annot>> endobj 1037 0 obj <>/Border[0 0 0]/H/N/Rect[274.961 163.459 330.224 154.163]/Subtype/Link/Type/Annot>> endobj 1038 0 obj <>/Border[0 0 0]/H/N/Rect[348.933 133.459 418.676 124.163]/Subtype/Link/Type/Annot>> endobj 1039 0 obj <>/Border[0 0 0]/H/N/Rect[361.381 93.4593 458.204 84.1632]/Subtype/Link/Type/Annot>> endobj 1047 0 obj <> endobj 1046 0 obj <> endobj 1045 0 obj <> endobj 1044 0 obj <> endobj 1043 0 obj <> endobj 1042 0 obj <> endobj 1041 0 obj <> endobj 1040 0 obj <> endobj 995 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.086 Tw 10 0 0 10 70.8661 724.8299 Tm (\017)Tj /Span<>> BDC ( )Tj EMC (\031\f\017\035\036\027\027\024\n \030\026\f\023\026\007\036 \030\036\035\ \024\020\024 \022\024\035\035\026\020\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026)Tj 0 Tw (-)Tj 0.618 Tw 0 -1.218 TD (\f\021\024\n\024\026. \025\035\026\f\f\017\004\036\f\022\017\036 \017\f\ \f\035\036\007\024\r\026\027\017\016 \017\n\036\027\036\027\017\005 )Tj 0.19 Tw T* (\r\027\036\022\035\036\021\024\004\027\024\020\024 \n\026\021\030\017\022\ \f\026 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\006\017\016\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\035\f\021\024\n )Tj 0.062 Tw T* [(\022\017\001\036\004\027\017\022\036 )0.6(\023\024\022\026\026\035\017, )0.5(\004\021\024 )0.5(\007\017\f\002\026\035\026\027\f )0.6(\n\036\032\007\031 )0.5(\f\017\027\021\036\024\n )]TJ 0.124 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.874 0 Td [(\007\036\020\030\026\007\026\006\017\036\005 )0.6(\022\024\035\035\026\020\036\027\026 )0.5(\026\f\f\024\006\017\017\030\024\r\026\027 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 17.145 0 Td (\023\024\r\t\001\036\027)Tj 0 Tw (-)Tj 0.039 Tw -18.019 -1.218 Td (\027\t\n \030\017\f\022\024\n \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \001\r\024\r [11]. \207\024\035\036\036 \027\024)Tj 0 Tw (-)Tj -0.003 Tw 0 -1.218 TD [(\r\t\036 \007\026\027\027\t\036 \023\024\007\021\r\036\030\032\007\026\033\ \021 )0.5(\030\024\035\034 MMP-9 \017)]TJ /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \235\036\030)Tj 0 Tw (-)Tj 0.076 Tw 0 -1.218 TD [(\n\036\027\021\024\r \n\026\021\030\017\022\f\027\024\020\024 )0.5(\030\036\n\024\007\036\035\017\030\024\r\026\027\017\016 )0.5(\022\026\022 \n\026\030\022\201\030\024\r )]TJ 0.502 Tw T* (\027\036\002\035\026\020\024\023\030\017\016\021\027\024\020\024 \021\036\ \004\036\027\017\016 \023\024\f\035\036 \022\024\035\024\030\036\022\021\ \026\035\034\027\t\b )Tj 0 Tw T* (\030\036\036\022\006\017\005 [12].)Tj 0.326 Tw T* (\200 \027\026\001\036\n \023\030\017\n\036\030\036 \017\n\036\027\027\024\ \f\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\035\017\027 )Tj 0.067 Tw T* (\024\022\026\026\035\f\016 \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \027\026\004\017\n\t\b \027\036\026\r\ \017\f\017\n\t\b )Tj -0.028 Tw 0 -1.218 TD (\023\030\036\007\017\022\021\024\030\024\r \203\202: OR 1,32 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\t\005 1 \n\022\n\024\035\034/\035 \017)Tj /Span<>> BDC ( )Tj EMC [(A)17.1(UC )]TJ 0.323 Tw 0 -1.218 TD (0,84 \f)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 80% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 )Tj 0.135 Tw 0 -1.218 TD (78% \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\030\024\020\036)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (15 \n\022\n\024\035\034/\035. \233\021\017 \023\024\022\026\026\021\036\ \035\017 \f\024)Tj 0 Tw (-)Tj 0.255 Tw T* (\023\024\f\021\026\r\017\n\t \f)Tj /Span<>> BDC ( )Tj EMC [(\007\017\026\023\026\024\027\024\n A)17(UC, \022\024\021\024\030\t\005 \024\023\017\f\t\r\026\033\021 )]TJ 0.136 Tw T* [(\007\035\016 \253\022\035\026\f\f\017\004\036\f\022\017\b\273 )0.5(\002\017\024\n\026\030\022\036\030\024\r \(\222\217\207, )0.5(\215\025\221\) \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\007)Tj 0 Tw (-)Tj 0.2 Tw T* [(\021\r\036\030\032\007\026\033\021, )0.6(\004\021\024 )0.5(\n\026\030\022\201\030\t )0.5(\007\036\020\030\026\007\026\006\017\017 )0.6(\022\024\035\035\026\020\036\027\026 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.065 Tw T* (\021\036\027\006\017\026\035\034\027\024 \n\024\020\031\021 \026\027\016\ \021\034 \r\026\032\027\024\036 \n\036\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\026\035\020\024\030\017\021\n\026\b )Tj 0 Tw T* (\030\026\027\027\036\020\024 \023\030\024\020\027\024\017\030\024\r\026\ \027\017\016.)Tj 0.063 Tw T* [(\203\036 \n\036\027\036\036 \027\026\004\017\n\t\n )0.5(\022\024\n\023\024\027\036\027\021\024\n \023\026\021\024\020\036\027\036\ \026 )0.5(\203\202 )0.5(\r\t)]TJ 0 Tw (-)Tj 0.486 Tw T* [(\f\021\031\023\026\036\021 )0.5(\r\027\031\021\030\017\002\030\033\001\027\026\016 )0.6(\020\017\023\036\030\021\036\027\017\016. )0.6(\215\024\r\t\001\036\027\017\036 )]TJ 0.254 Tw T* [(\200\207\212 )0.5(\r\036\007\201\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 5.9 0 Td [(\f\027\017\032\036\027\017\033 )0.6(\f\023\035\026\027\b\027\017\004\036\f\022\024\005 )0.6(\023\036\030\235\031\017\017, )]TJ 0.105 Tw -5.9 -1.218 Td (\031\b\031\007\001\036\027\017\033 \n\017\022\030\024\006\017\030\022\031\ \035\016\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\036 \022\017\001\022\017, \030\024\f\021\031 )Tj 0.415 Tw T* (\r\027\031\021\030\017\023\030\024\f\r\036\021\027\024\020\024 \007\026\r\ \035\036\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\b\026\027\017\004\036\f\022\024\005 \027\026)Tj 0 Tw (-)Tj 0.089 Tw T* (\020\030\031\022\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\017\027\017\033 \001\r\024\r. \216\024\021\016 \f\023\036\006\017\026\ \035\034\027\t\b \030\026\002\024\021, \023\024)Tj 0 Tw (-)Tj 0.382 Tw T* (\f\r\016\013\201\027\027\t\b \200\207\212 \022\026\022 \022\024\035\017\004\ \036\f\021\r\036\027\027\024\n\031 \023\030\036\007\017\022\021\024\030\031\ )Tj 0.005 Tw T* (\203\202, \027\036\n\027\024\020\024, \007\026\027\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\027\024\005 \020\017\023\036\030\021\ \036\027\017\017 )Tj 0.161 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\026\002\007\024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\ \017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\024\n \007\036\n\024\027\f\021\030\017\030\031\033\021 )Tj 0.115 Tw T* [(\036\201 )0.5(\004\201\021\022\031\033 )0.5(\026\f\f\024\006\017\026\006\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 10.686 0 Td [(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 )0.6(\024\030\020\026\027)]TJ 0 Tw (-)Tj 0.081 Tw -10.686 -1.218 Td (\027\024\005 \007\017\f\235\031\027\022\006\017\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\f\035\024\032\027\036\027\017\016\n\017. \200)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\005 \n\024\007\036\035\017 )Tj 0.115 Tw T* (\200\207\212)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (15 \n\n \030\021. \f\021. \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\ \017\017 )Tj 0.292 Tw T* [(\f\024\023\030\024\r\024\032\007\026\035\024\f\034 A)17.1(UC 0,78, \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 )0.5(74% )]TJ 0.263 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 72%, \026)Tj /Span<>> BDC ( )Tj EMC (\035\024\020\017\f\021\017\004\036\f\022\017\005 \022\024\220\235\235\017\ )Tj 0 Tw (-)Tj 0.169 Tw T* (\006\017\036\027\021 \(\210\231 1,20 \027\026)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\t\005 1 \n\n \030\021. \f\021.\) \031\022\026\t\r\026\036\ \021 )Tj -0.024 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.182 0 Td [(\016\030\022\024 )0.5(\r\t\030\026\032\036\027\027\t\005 )0.6(\007\024\024\026\r\017\f\017\n\t\005 )0.6(\b\026\030\026\022\021\036\030 )0.5(\030\017\f\022\026.)]TJ 0.059 Tw -1.182 -1.218 Td (\230\027\021\036\020\030\026\035\034\027\026\016 \n\024\007\036\035\034,\ \r\022\035\033\004\026\033\013\026\016 \f\r\024\002\024\007\027\t\005 \024\ \022\f\017)Tj 0 Tw (-)Tj 0.087 Tw T* (\023\030\024\035\017\027, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC [(\204\212\202, \023\024\022\026\026\035\026 A)17(UC 0,90, \004\021\024 \f\024\023\024\f\021\026)]TJ 0 Tw (-)Tj 0.081 Tw T* (\r\017\n\024 \f)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\017\n\017 \022\024\n\002\017\027\017\030\024\r\026\027\027\ \t\n\017 \001\022\026\035\026\n\017, \023\030\036\007)Tj 0 Tw (-)Tj 0.13 Tw T* (\035\024\032\036\027\027\t\n\017 \007\035\016 \222\217\207, \215\025\221\ \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b \024\006\036\027\024\004\027\t\b\ )Tj 0 Tw T* [(\f\017\f\021\036\n \(\027\026\023\030\017\n\036\030, Dutch leak)-16.8(a)-17(ge scor)-24(e \017)]TJ /Span<>> BDC ( )Tj EMC (\007\030.\) [10].)Tj 0.558 Tw T* (\222 \023\030\026\022\021\017\004\036\f\022\024\005 \021\024\004\022\017\ \030\036\027\017\016 \023\024\035\031\004\036\027\027\t\036 \007\026\027\ )Tj 0 Tw (-)Tj 0.516 Tw T* (\027\t\036 \235\024\030\n\017\030\031\033\021 \022\024\027\006\036\023\006\ \017\033 \030\026\027\027\036\005 \f\021\030\026\021\017\235\017\022\026\ )Tj 0 Tw (-)Tj 0.405 Tw T* (\006\017\017 \030\017\f\022\026. \215\026\006\017\036\027\021\024\r, \031\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \031\032\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 )Tj 0.695 Tw T* (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\ \t\016\r\035\016\033\021\f\016: \f\r\024\002\024\007\027\t\005 )Tj 0.316 Tw T* (\024\022\f\017\023\030\024\035\017\027)Tj /Span<>> BDC ( )Tj EMC 5.471 0 Td (>)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td (15)Tj /Span<>> BDC ( )Tj EMC 1.548 0 Td [(\n\022\n\024\035\034/\035, )0.5(\200\207\212)]TJ /Span<>> BDC ( )Tj EMC 6.915 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC 1.048 0 Td [(15 )0.5(\n\n )0.5(\030\021. )0.5(\f\021. )]TJ 0.105 Tw -16.032 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (4)Tj /Span<>> BDC ( )Tj EMC (\027\n\024\035\034/\n\035, \n\024\032\027\024 \024\021\027\036\f\021\017\ \022)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \r\t\f\024)Tj 0 Tw (-)Tj 0.208 Tw T* (\022\024\020\024 \030\017\f\022\026 \203\202 \017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\f\n\026\021\030\017\r\026\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017: \031\f\017)Tj 0 Tw (-)Tj 0.042 Tw T* (\035\036\027\027\024\020\024 \n\024\027\017\021\024\030\017\027\020\026,\ \002\024\035\036\036 \032\201\f\021\022\024\020\024 \022\024\027\021\030\ \024\035\016 \200\207\212, )Tj 0.208 Tw T* (\022\024\030\030\036\022\006\017\017 \024\022\f\017\007\026\021\017\r\027\ \024\020\024 \f\021\030\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 \027\017\022\024\020\024 )Tj 0.146 Tw T* (\023\024\030\024\020\026 \007\035\016 \r\t\023\024\035\027\036\027\017\016\ \007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \030\036\035\026\ \023\026\030\024)Tj 0 Tw (-)Tj T* (\021\024\n\017\017 \017\035\017 \030\036\r\017\017\017 \026\027\026\f\021\ \024\n\024\026.)Tj 0.204 Tw T* (\210\004\036\r\017\007\027\024, \004\021\024 \023\030\036\007\035\024\032\ \036\027\027\026\016 \n\024\007\036\035\034 \021\030\036\002\031\036\021\ \r\026\035\017)Tj 0 Tw (-)Tj 0.281 Tw T* (\007\026\006\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\r\017\f\017\n\t\b \r\t\002\024\030\022\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\035\036\027\017\016 )Tj 0.67 Tw 23.244 64.543 Td (\f)Tj /Span<>> BDC ( )Tj EMC 1.339 0 Td [(\f\031\013\036\f\021\r\031\033\013\017\n\017 )0.6(\026\035\020\024\030\017\021\n\026\n\017, )0.6(\002\026\017\030\031\033\013\017\n\017\f\016 )]TJ 0.124 Tw -1.339 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\222\217\207, \215\025\221 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\022\024-\030\026\007\017\024\035\024\020\017\004\036\ \f\022\017\b \022\030\017\021\036\030\017\016\b. )Tj 0.199 Tw T* [(\210\007\027\026\022\024 \f\024\023\024\f\021\026\r\017\n\024\f\021\034 \ \027\026\001\017\b \031\f\035\024\r\027\t\b A)17(UC \017)]TJ /Span<>> BDC ( )Tj EMC (\210\231 )Tj 0.034 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\t\n\017 \f\024\r\030\036\n\036\027\027\t\b \017\f\f\035\ \036\007\024\r\026\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\n\026\030\022\036)Tj 0 Tw (-)Tj 0.109 Tw T* (\030\026\n \203\202 \f\r\017\007\036\021\036\035\034\f\021\r\031\036\021\ \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \r\022\035\033\004\036\027\017\036 \023\024\022\ \026)Tj 0 Tw (-)Tj -0.001 Tw T* (\026\021\036\035\036\005 \024\022\f\017\007\026\021\017\r\027\024\020\024\ \f\021\030\036\f\f\026, \022\024\035\035\026\020\036\027\024\035\017\026\ \017)Tj /Span<>> BDC ( )Tj EMC (\200\207\212 )Tj -0.032 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\t\036 \001\022\026\035\t \ \017\n\036\036\021 \030\036\026\035\034\027\t\036 \023\036\030\f\023\036\ \022\021\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\t [13].)Tj 0.048 Tw T* (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \001\r\024\ \r \021\024\035\f\021\024\022\017\001\036\004\027\024\020\024 \026\027\026\ \f\021\024\n\024)Tj 0 Tw (-)Tj 0.039 Tw T* (\026 \024\f\021\026\201\021\f\016 \024\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\017\002\024\035\036\036 \021\016\032\201\035\t\b \024\f\035\024\ \032\027\036\027\017\005 )Tj -0.038 Tw T* (\030\036\036\022\006\017\024\027\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026\027\024\r\017\021\036\035\034\027\t\b \024\023\036\030\ \026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\035)Tj 0 Tw (-)Tj -0.016 Tw T* (\f\021\024\005 \022\017\001\022\036; \036\201 \030\026\r\017\021\017\036\ \024\002\031\f\035\024\r\035\036\027\024 \f\024\004\036\021\026\027\017\ \036\n \027\026)Tj 0 Tw (-)Tj 0.228 Tw 0 -1.218 TD (\030\031\001\036\027\017\005 \n\017\022\030\024\006\017\030\022\031\035\016\ \006\017\017, \024\022\f\017\007\026\021\017\r\027\024\020\024 \f\021\030\ \036\f\f\026, )Tj 0.116 Tw 0 -1.218 TD (\007\036\020\030\026\007\026\006\017\017 \022\024\035\035\026\020\036\027\ \024\r\024\020\024 \n\026\021\030\017\022\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\024\005 \020\017\023\036\030\021\036\027\017\017.)Tj 0.034 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \031\032\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 )Tj 0.032 Tw T* (\023\024\f\035\036 \024\023\036\030\026\006\017\017 \r\t\016\r\035\016\033\ \021\f\016 \r\t\030\026\032\036\027\027\t\036 \017\n\036\027\036\027\017\ \016 )Tj 0.165 Tw T* (\023\030\024- \017)Tj /Span<>> BDC ( )Tj EMC (\026\027\021\017\024\022\f\017\007\026\027\021\027\024\020\024 \002\026\035\ \026\027\f\026 \(\023\024\r\t\001\036\027\017\036 \204\212\202 )Tj 0.414 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\017\036\027\024\r\t\b \022\024\027\255\033\020\026\021\024\r, \f\027\ \017\032\036\027\017\036 \026\f\022\024\030\002\017\027\024\r\024\005 )Tj -0.006 Tw T* (\022\017\f\035\024\021\t\), \023\024\022\026\026\021\036\035\017 \021\022\ \026\027\036\r\024\005 \020\017\023\024\022\f\017\017 \(\030\024\f\021 \035\ \026\022\021\026)Tj 0 Tw (-)Tj -0.012 Tw T* [(\021\026\), \031\f\017\035\036\027\017\036 \022\024\035\035\026\020\036\027\ \024\035\017\026 )0.5(\(\023\024\r\t\001\036\027\017\036 )0.5(\f\r\024\002\024\007\027\024\020\024 )]TJ 0.249 Tw T* (\024\022\f\017\023\030\024\035\017\027\026\), \f\027\017\032\036\027\017\ \036 \022\024\027\006\036\027\021\030\026\006\017\017 \f\036\030\024\021\ \024\027\017\027\026 )Tj 0.019 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.769 0 Td [(\027\026\004\017\n\024\036 )0.5(\031\r\036\035\017\004\036\027\017\036 )0.5(\200\207\212 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 12.443 0 Td [(\f\030\026\r\027\036\027\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t)Tj 0 Tw (-)Tj 0.171 Tw -13.212 -1.218 Td (\n\017 \f)Tj /Span<>> BDC ( )Tj EMC (\002\035\026\020\024\023\030\017\016\021\027\t\n \021\036\004\036\027\017\ \036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\ \024 )Tj 0 Tw T* (\023\036\030\017\024\007\026.)Tj 0.114 Tw T* [(\025\024\n\002\017\027\017\030\024\r\026\027\027\026\016 )0.6(\023\030\024\020\027\024\f\021\017\004\036\f\022\026\016 )0.6(\n\024\007\036\035\034, )0.5(\r\022\035\033\004\026)]TJ 0 Tw (-)Tj 0.132 Tw T* (\033\013\026\016 \f\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\ \035\017\027, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202, \024\002\035\026\007\026\036\021 )Tj 0.289 Tw T* [(\r\t\f\024\022\024\005 )0.5(\007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 )0.6(\006\036\027\027\024\f\021\034\033 )0.6(\(A)17(UC)]TJ /Span<>> BDC ( )Tj EMC 19.034 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 1.021 0 Td (0,90\) )Tj 0.173 Tw -20.055 -1.218 Td (\f)Tj /Span<>> BDC ( )Tj EMC (\004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 \024\022\024\ \035\024 85% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 )Tj 0.214 Tw T* (\023\024\030\016\007\022\026 80% \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\023\024\f\021\026\r\017\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\024\004\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\001\017)Tj 0 Tw (-)Tj 0.542 Tw T* [(\n\017 )0.5(\024\023\031\002\035\017\022\024\r\026\027\027\t\n\017 )0.5(\026\035\020\024\030\017\021\n\026\n\017, )0.5(\024\f\027\024\r\026\027\027\t\n\017 )]TJ 0.03 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b \222\217\207, \023\030\024\022\026\ \035\034\006\017\021\024\027\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\017\b )Tj 0 Tw T* (\001\022\026\035\026\b.)Tj 0.086 Tw T* (\212\035\016 \024\022\024\027\004\026\021\036\035\034\027\024\005 \024\006\ \036\027\022\017 \022\035\017\027\017\004\036\f\022\024\005 \027\026\004\ \017\n\024\f\021\017 )Tj 0.532 Tw T* (\023\030\036\007\035\024\032\036\027\027\t\b \023\030\024\020\027\024\f\021\ \017\004\036\f\022\017\b \017\027\007\017\022\026\021\024\030\024\r \027\ \036)Tj 0 Tw (-)Tj 0.185 Tw T* [(\024\002\b\024\007\017\n\t \023\030\024\f\023\036\022\021\017\r\027\t\036\ )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 \f)]TJ /Span<>> BDC ( )Tj EMC (\031\004\026\f\021\017\036\n )Tj 0.232 Tw T* (\002\024\035\034\001\017\b \027\036\026\r\017\f\017\n\t\b \022\024\020\024\ \030\021 \023\026\006\017\036\027\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\t\n )Tj -0.033 Tw T* (\f\030\026\r\027\036\027\017\036\n \f)Tj /Span<>> BDC ( )Tj EMC (\f\031\013\036\f\021\r\031\033\013\017\n\017 \002\017\024\n\026\030\022\036\ \030\027\t\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\017)Tj 0 Tw (-)Tj T* (\027\017\022\024-\030\026\007\017\024\035\024\020\017\004\036\f\022\017\n\ \017 \n\024\007\036\035\016\n\017.)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (\017\027\022\032\025\034\030\036\025\034\223 \034\255\255\035\036\031\017\ \026\032\025\034\223)Tj /T1_0 1 Tf -0.007 Tw 0 -1.218 TD (\203\026\f\021\024\016\013\036\036 \017\f\f\035\036\007\024\r\026\027\017\ \036 \r\t\023\024\035\027\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\021\030\024\f\023\036\022\021\017\r)Tj 0 Tw (-)Tj 0.208 Tw T* (\027\024\n \007\017\026\005\027\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \253\f\035\031\004\026\005\226\022\024\027\021\030\024\035\ \034\273 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017)Tj 0 Tw (-)Tj 0.205 Tw T* [(\030\024\r\026\027\017\036\n )0.5(\f\024\023\024\f\021\026\r\017\n\024\005 )0.6(\020\030\031\023\023\t )0.5(\023\026\006\017\036\027\021\024\r )0.6(\002\036 )0.5(\203\202. )]TJ 0.092 Tw T* (\221\026\022\024\005 \023\024\007\b\024\007 \023\024\r\024\035\016\036\021\ \035\031\004\001\036 \022\024\027\021\030\024\035\017\030\024\r\026\021\ \034 \r\035\017)Tj 0 Tw (-)Tj 0.259 Tw T* [(\016\027\017\036 \002\026\024\r\t\b \022\024\027\235\026\031\027\007\036\ \030\024\r, )0.5(\024\007\027\026\022\024 \024\020\030\026\027\017\004\017\r\026\036\021 \ )]TJ 0.156 Tw T* (\024\002\024\002\013\026\036\n\024\f\021\034 \023\024\035\031\004\036\027\ \027\024\005 \023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \n\ \024\007\036\035\017 )Tj 0.252 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (\r\f\033 \023\024\023\031\035\016\006\017\033 \002\024\035\034\027\t\b, \ \023\036\030\036\027\201\f\001\017\b \030\036\036\022\006\017\017 )Tj 0.209 Tw T* (\021\024\035\f\021\024\005 \022\017\001\022\017. \212\024\023\024\035\027\ \017\021\036\035\034\027\t\n \024\020\030\026\027\017\004\036\027\017\036\ \n \016\r)Tj 0 Tw (-)Tj -0.009 Tw T* (\035\016\036\021\f\016 \024\021\027\024\f\017\021\036\035\034\027\024 \027\ \036\002\024\035\034\001\024\005 \024\002\255\201\n \r\t\002\024\030\022\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021)Tj 0 Tw (-)Tj 0.102 Tw T* (\f\031\021\f\021\r\017\036 \r\027\036\001\027\036\005 \(\n\036\032\006\036\ \027\021\030\024\r\024\005\) \r\026\035\017\007\026\006\017\017 \n\024\007\ \036)Tj 0 Tw (-)Tj 0.105 Tw T* [(\035\017. \212\035\016 \024\022\024\027\004\026\021\036\035\034\027\024\020\ \024 \023\024\007\021\r\036\030\032\007\036\027\017\016 )0.5(\023\024\035\031\004\036\027\027\t\b )]TJ 0.126 Tw T* (\030\036\031\035\034\021\026\021\024\r \027\036\024\002\b\024\007\017\n\ \t \023\030\024\f\023\036\022\021\017\r\027\t\036 \017\f\f\035\036\007\024\ \r\026)Tj 0 Tw (-)Tj T* (\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\027\036\026\r\017\f\017\n\t\b \022\024\020\024\030\021\027\t\b \r\t\002\ \024\030\022\026\b.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_3 1 Tf 25 0 0 25 28.14 56.0378 Tm (98)Tj ET endstream endobj 993 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.391 Tw 10 0 0 10 42.5197 724.8299 Tm [(\024\022\f\017\023\030\024\035\017\027 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035 )0.6(\b\024\030\024\001\031\033 )0.5(\007\017\f\022\030\017)]TJ 0 Tw (-)Tj 0.143 Tw 0 -1.218 TD [(\n\017\027\017\030\031\033\013\031\033 )0.5(\f\023\024\f\024\002\027\024\f\021\034: )0.5(A)17(UC )0.5(0,83 \(95% )0.5(\212\230 0,72\226)]TJ 0 Tw T* (0,93; )Tj /T1_2 1 Tf 2.321 0 Td (p)Tj /T1_1 1 Tf 0.092 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). \215\024\030\024\020\024\r\024\036 \027\026\004\036\027\017\036\ )Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC (\n\022\n\024\035\034/\035 )Tj 0.193 Tw -2.321 -1.218 Td (\024\002\036\f\023\036\004\017\r\026\035\024 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\034 79,1% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004)Tj 0 Tw (-)Tj 0.24 Tw T* (\027\024\f\021\034 77,3%, \f)Tj /Span<>> BDC ( )Tj EMC (\215\215\037 87,2% \017)Tj /Span<>> BDC ( )Tj EMC (\210\215\037 65,4%. \212\035\016 \200\207\212 )Tj 0.276 Tw T* (\023\024\030\024\020)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC (15)Tj /Span<>> BDC ( )Tj EMC [(\n\n \030\021. \f\021. \b\026\030\026\022\021\036\030\017\024\r\026\035\ \f\016 A)17(UC 0,78 )]TJ 0.251 Tw 0 -1.218 TD (\(95% \212\230 0,65\2260,90; )Tj /T1_2 1 Tf 0 Tw 9.039 0 Td (p)Tj /T1_1 1 Tf 0.251 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC 1.945 0 Td (0,001\), \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\033 )Tj 0.371 Tw -10.984 -1.218 Td (69,8% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004\027\024\f\021\034\033 72,7%. \212\035\016\ \204\212\202 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\030\024\020\024\n)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC [(4,0 \027\n\024\035\034/\n\035 A)17(UC \f\024\f\021\026\r\017\035\026 0,80 \(95% \212\230 )]TJ 0 Tw T* (0,68\2260,91; )Tj /T1_2 1 Tf 4.787 0 Td (p)Tj /T1_1 1 Tf 0.317 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 74,4%, )Tj 0 Tw -4.787 -1.218 Td (\f\023\036\006\017\235\017\004\027\024\f\021\034)Tj /Span<>> BDC ( )Tj EMC (\227 77,3%.)Tj 0.059 Tw T* (\230\027\021\036\020\030\026\035\034\027\026\016 \n\024\007\036\035\034,\ \r\022\035\033\004\026\033\013\026\016 \f\r\024\002\024\007\027\t\005 \024\ \022\f\017)Tj 0 Tw (-)Tj -0.007 Tw 0 -1.218 TD (\023\030\024\035\017\027, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202, \023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\ \035\026 \027\026\017\r\t\f\001\031\033 )Tj 0.125 Tw 0 -1.218 TD [(\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \021\024\004\027\ \024\f\021\034: A)17(UC 0,93 \(95% \212\230 0,84\226)]TJ 0 Tw 0 -1.218 TD (0,98; )Tj /T1_2 1 Tf 2.442 0 Td (p)Tj /T1_1 1 Tf 0.213 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \023\030\036\r\024\f\b\024\007\016 \022\026\032\007\t\005 \017\ )Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\034\027\t\b )Tj 0 Tw -2.442 -1.218 Td (\n\026\030\022\036\030\024\r \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\035\024\013\026\007\017 \023\024\007 )Tj /T1_2 1 Tf -0.019 Tc 0.019 Tw [(RO)-18.9(C)]TJ /T1_1 1 Tf 0 Tc 0 Tw 12.467 0 Td (-\022\030\017\r\024\005 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.01 Tc 0.435 Tw -12.467 -1.218 Td (\221\026\022\017\n \024\002\030\026\024\n, \023\024\022\026\026\021\036\ \035\017, \024\021\030\026\032\026\033\013\017\036 \017\027\021\036\027)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.252 Tw T* [(\f\017\r\027\024\f\021\034 )0.5(\022\024\035\035\026\020\036\027\024\035\017\026 )0.5(\(\f\r\024\002\024\007\027\t\005 )0.5(\024\022\f\017\023\030\024\035\017\027\),)10( )]TJ 0.232 Tw T* [(\r\t\030\026\032\036\027\027\024\f\021\034 )0.5(\r\027\031\021\030\017\002\030\033\001\027\024\005 )0.5(\020\017\023\036\030\021\036\027\017\017 )0.5(\(\200\207\212\))10( )]TJ 0.165 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.935 0 Td [(\031\030\024\r\036\027\034 )0.5(\023\036\030\036\022\017\f\027\024\020\024 )0.5(\024\022\017\f\035\036\027\017\016 )0.5(\035\017\023\017\007\024\r )0.5(\(\204\212\202\),)10( )]TJ 0.352 Tw -0.935 -1.218 Td [(\024\002\035\026\007\026\033\021 )0.5(\r\t\f\024\022\024\005 )0.5(\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 )0.5(\027\026\004\017\n\024\f\021\034\033)10( )]TJ 0.373 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\017 \030\017\f\022\026 \027\036\f\024\f\ \021\024\016\021\036\035\034\027\024\f\021\017 \021\024\035\f\021\024\022\ \017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.345 Tw T* (\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\n\024\020\031\021 \002\t\021\034 \017\f\023\024\035\034\024\r\026\027\t\ )10( )]TJ 0.031 Tw T* [(\007\035\016 )0.5(\030\026\027\027\036\005 )0.5(\007\017\235\235\036\030\036\027\006\017\026\006\017\017 )0.5(\023\026\006\017\036\027\021\024\r )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 18.769 0 Td [(\f\021\036\023\036\027\017)10( )]TJ -0.01 Tw -18.769 -1.218 Td (\030\017\f\022\026.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 14 0 0 14 275.0305 724.8299 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc -0.045 Tw 10 0 0 10 274.9606 700.4739 Tm [(\215\024\035\031\004\036\027\027\t\036 )0.6(\007\026\027\027\t\036 )0.5(\023\024\007\021\r\036\030\032\007\026\033\021 )0.6(\n\031\035\034\021\017\235\026\022\021\024\030\027\031\033 )]TJ 0.145 Tw T* (\023\030\017\030\024\007\031 \027\036\f\024\f\021\024\016\021\036\035\034\ \027\024\f\021\017 \026\027\026\f\021\024\n\024\026, \027\026)Tj /Span<>> BDC ( )Tj EMC (\004\021\024 \031\022\026)Tj 0 Tw (-)Tj T* (\t\r\026\033\021 \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\036 \024\002\024\030\t [9].)Tj 0.117 Tw T* (\217\016\007 \n\036\021\026\026\027\026\035\017\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\f\017\f\021\036\n\026\021\017\004\036\f\022\017\b \024\002\024\030\024\ \r \023\024\022\026)Tj 0 Tw (-)Tj -0.042 Tw T* (\026\035, \004\021\024 \007\017\027\026\n\017\022\026 CRP \017)Tj /Span<>> BDC ( )Tj EMC (\215\025\221 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\036 3\2265)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\024\022 \023\024\f\035\036 )Tj -0.007 Tw 0 -1.218 TD [(\022\024\035\024\030\036\022\021\026\035\034\027\t\b \030\036\036\022\006\ \017\005 \024\002\036\f\023\036\004\017\r\026\036\021 A)17(UC \023\024\030\016\007\022\026 )]TJ 0.172 Tw 0 -1.218 TD [(0,80\2260,90, \023\024\r\024\035\016\016 \007\024\f\021\026\021\024\004\ \027\024 )0.5(\027\026\007\201\032\027\024 \017\f\022\035\033\004\026\021\034 )]TJ 0.205 Tw T* (\203\202 \023\030\017)Tj /Span<>> BDC ( )Tj EMC 3.561 0 Td [(\027\017\022\017\b \027\026\004\036\027\017\016\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\f\r\024\036\r\030\036\n\036\027\027\024 )0.5(\026\023\024\007\024)]TJ 0 Tw (-)Tj 0.201 Tw -3.561 -1.218 Td (\030\017\021\034 \024\f\035\024\032\027\036\027\017\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \027\026\030\026\f\021\026\027\017\017 [10]. \221\036\n \027\036 \ )Tj 0.038 Tw T* (\n\036\027\036\036, \220\021\017 \n\026\030\022\201\030\t \024\021\030\026\ \032\026\033\021, \023\030\036\032\007\036 \r\f\036\020\024, \f\017\f\021\ \036\n)Tj 0 Tw (-)Tj 0.058 Tw 0 -1.218 TD [(\027\024\036 )0.5(\r\024\f\023\026\035\036\027\017\036, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 7.821 0 Td [(\021\024 )0.5(\r\030\036\n\016 )0.5(\022\026\022 )0.6(\035\024\022\026\035\034\027\t\036 )0.5(\023\030\024\006\036\f\f\t )]TJ -0.001 Tw -7.821 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC 0.705 0 Td [(\024\027\036 )0.5(\026\027\026\f\021\024\n\024\026 )0.5(\(\024\022\f\017\007\026\021\017\r\027\t\005 )0.5(\f\021\030\036\f\f, )0.6(\007\036\020\030\026\007\026\006\017\016 )]TJ 0.297 Tw -0.705 -1.218 Td (\022\024\035\035\026\020\036\027\026, \027\026\030\031\001\036\027\017\016\ \n\017\022\030\024\006\017\030\022\031\035\016\006\017\017\) \024\f\021\ \026\033\021\f\016 )Tj -0.031 Tw 0 -1.218 TD (\n\036\027\036\036 \017\f\f\035\036\007\024\r\026\027\027\t\n\017. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \001\017\030\024\022\024 \017\f\023\ \024\035\034)Tj 0 Tw (-)Tj 0.169 Tw 0 -1.218 TD (\031\036\n\t\b \r\024\f\023\026\035\017\021\036\035\034\027\t\b \n\026\030\ \022\036\030\024\r \(\222\217\207\), \017\031\004\036\027\027\t\036 )Tj 0.156 Tw 0 -1.218 TD (\027\026\n\017 \023\024\022\026\026\021\036\035\017 \024\021\030\026\032\ \026\033\021 \f\023\036\006\017\235\017\004\036\f\022\017\036 \023\026\021\ \024\235\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\017\024\035\024\020\017\004\036\f\022\017\036 \r\036\027\034\016.)Tj 0.725 Tw 0 -1.218 TD (\210\f\024\002\036\027\027\024\f\021\034\033 \023\030\036\007\f\021\026\r\ \035\036\027\027\024\005 \030\026\002\024\021\t \016\r\035\016\036\021\f\ \016 )Tj 0.495 Tw T* (\026\022\006\036\027\021 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\021\036\035\016\b, \024\021\030\026\032\026\033\013\ \017\b \f\021\030\031\022\021\031\030\027\024-)Tj 0.381 Tw 0 -1.218 TD (\235\031\027\022\006\017\024\027\026\035\034\027\024\036 \f\024\f\021\024\ \016\027\017\036 \f\024\036\007\017\027\017\021\036\035\034\027\024\005 \ \021\022\026\027\017 )Tj 0.118 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\r\024\020\024 \022\026\030\022\026\f\ \026 \f\021\036\027\022\017 \022\017\001\022\017. \215\024\r\t\001\036\027\ \017\036 )Tj 0.21 Tw 0 -1.218 TD (\031\030\024\r\027\016 \f\r\024\002\024\007\027\024\020\024 \024\022\f\017\ \023\030\024\035\017\027\026 \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 )Tj 0.772 Tw T* (\f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \024\002 \026\022\021\ \017\r\017\026\006\017\017 \022\024\035\035\026\020\036\027\024\035\017\ \026 )Tj ET q /GS0 gs 453.543294 0 0 262.0472365 42.5196991 144.2708787 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.095 Tw 9 0 0 9 42.5197 133.3701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( ROC-\n\032\022\021\013\027 \024\021\031\240\031\030\025\031\b\031 \031\n\ \024\022\033\032\031\f\022\025\020, \021\025\r\023\032\022\240\032\005\213\ \025\031\b\031 \030\020\021\f\027\025\022\t, \026\020\f\031\025\031\021\031\ \b\031 \030\022\020\f\017\030\027\b\022\030\020 \022)Tj /Span<>> BDC ( )Tj EMC (\022\025\023\027\b\032\020\f\017\025\031\235 )Tj 0.085 Tw 0 -1.2 TD [(\026\031\030\027\f\022 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 4.071 0 Td [(\033\032\031\b\025\031\016\022\032\031\021\020\025\022\022 )0.6(\025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\022 )0.6(\023\031\f\024\023\031\n\022\213\027\007\025\031\b\031 )0.6(\020\025\020\024\023\031\026\031\016\020. )0.6(\205\021\031\240\031\030\025\013\235 \031\n\024\022\033\032\031\f\022\025\ : AUC 0,83; )0.5(\211\221\220: )]TJ 0 Tw -4.071 -1.2 Td (AUC 0,78; \215\220\003: AUC 0,80; \022\025\023\027\b\032\020\f\017\025\020\ \t \026\031\030\027\f\017: AUC 0,93)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.037 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)19(OC cur)-42(v)13(es for free h)12(y)14(dro)14(xyp)46(roline, intra-abdominal p)46(ressure, malondialdeh)12(y)14(de, and the)]TJ /Span<>> BDC ( )Tj EMC [(integ)14(rated model in p)46(redicting )]TJ 0.091 Tw T* [(colonic anastomo)13.1(tic leak)11.1(ag)12(e. 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DmHi0J(UTDΨ^UX\?xc3ތ ;p5UEtӚ**y0Ha7Na;zdg*gKz[ˁ0Z/#^08тƦ)&f'#?  :08:pTo>ypX48ӍT33USf@>oN+<%X6ov&8`hi2LK碝a"x bѲapq5ͣ5/% mz=jk MTM32LiFxkW{ѽчa;14SŊg46 >/5313UU`-3m%:ђo3F]3yN֧ɓ6Gේ<Wql 8H*+&rDⷫzpۇFqjꮩ֪@`&Nv7yŢ"cDDFxco>z4ՁMULr33េUTW]SUa(iH圑iѽFNN U\a33M7Yc{[ ᷼T׀o6 y눣crZ[7V`0{́|.[~0<|j'b")]@0{ 4o.4t^5ULSD˦nNoVyia92D=[ɇ޽}bj)ͼ<Ɇo M F-8}׃TUH> xioNyp͢hΈ_*w0̈́z' N(/fx|457]5awl>&&"8NU1/O6kaX<5Sa"UV4dL.Npq(,DQU89^C *w >mcx8 "ic8H^K>6)ޝ-hW|>cxHUc \M3N\ӜHa$F L")"5dm7#yVW5b&qfEYX}`w᳼8*>ovz0115Uy`uSMW3Ž4N N,4apxZiM4U3LETL[USDa&i'2_5xl<)F W45QT^&"כX}INx^(ެ{ -ŧ ]X>R-Mފ7co Myqq_YsDLD$CFa]hӵ1گ j\5;,ڋૌi&^C実 xkov\-QUX<TlfѲF4D艗xi/c.-Xk.55WS1V\`x+SUu&)\DDg0US4UhUj6x|aɍl>>stream endstream endobj 992 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.029 Tw 10 0 0 10 70.8661 444.7359 Tm (\030\021. \f\021.; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.029 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). \215\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\024\030\026\f\021\027\t\n \b\026\030\026\022\021\036\ \030\017\f\021\017)Tj 0 Tw (-)Tj -0.029 Tw 0 -1.218 TD (\022\026\n \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\n \023\024\ \022\026\026\021\036\035\016\n \027\036 \002\t\035\024 \031\f\021\026)Tj 0 Tw (-)Tj 0.135 Tw T* (\027\024\r\035\036\027\024 \027\026\035\017\004\017\036 \f\021\026\021\017\ \f\021\017\004\036\f\022\017 \027\026\004\017\n\t\b \030\026\035\017\004\ \017\005 )Tj 0 Tw T* (\n\036\032\007\031 \020\030\031\023\023\026\n\017.)Tj 0.383 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \031\030\024\r\036\027\034 \f\ \r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026 )Tj 0.028 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\024\005 \020\030\031\023\023\036 \002\t\035 \f\021\026\ \021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \r\t\001\036\ , )Tj 0.011 Tw T* (\004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \(18,0 [15,7\226\ 19,6] \023\030\024\021\017\r 12,7 )Tj 0.082 Tw T* ([11,1\22614,8] \n\022\n\024\035\034/\035; )Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.082 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \004\021\024 \f\r\017\007\036\021\036\035\034\f\021\r\031)Tj 0 Tw (-)Tj 0.176 Tw T* (\036\021 \024\002 \026\022\021\017\r\027\024\n \030\026\030\031\001\036\ \027\017\017 \022\024\035\035\026\020\036\027\024\r\024\020\024 \n\026\021\ \030\017\022)Tj 0 Tw (-)Tj 0.135 Tw T* (\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026\f\021\024\n\024\026. \215\024\022\026\026\021\ \036\035\017 \200\207\212 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \203\202 )Tj 0.328 Tw T* (\f\024\024\021\r\036\021\f\021\r\024\r\026\035\017 \r\027\031\021\030\017\ \002\030\033\001\027\024\005 \020\017\023\036\030\021\036\027\017\017 I\ \226II )Tj 0.085 Tw T* (\f\021\036\023\036\027\017, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\021\030\024\035\034\027\024\005 \020\030\031\023\023\036 \024\ \f\021\026\r\026\035\017\f\034 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\036\035\026\b \007\024\023\031\f\021\017\n\t\b \027\026\ \004\036\027\017\005.)Tj 0.131 Tw T* [(\212\035\016 \023\024\f\021\030\024\036\027\017\016 \n\027\024\020\024\235\ \026\022\021\024\030\027\024\005 )0.5(\035\024\020\017\f\021\017\004\036\f\022\024\005 \030\036)]TJ 0 Tw (-)Tj 0.283 Tw T* (\020\030\036\f\f\017\024\027\027\024\005 \n\024\007\036\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\b\024\007\027\t\005 \023\031\035 \023\030\036\007\017\022\021\024\ \030\024\r )Tj 0.419 Tw T* [(\r\022\035\033\004\026\035\017 )0.6(\023\024\022\026\026\021\036\035\017, )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\r\001\017\036\ )0.6(\023\024)]TJ 0 Tw (-)Tj 0.169 Tw T* [(\021\036\027\006\017\026\035\034\027\031\033 )0.6(\026\f\f\024\006\017\026\006\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 12.061 0 Td [(\203\202 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 3.489 0 Td (\024\007\027\024\235\026\022\021\024\030\027\024\n )Tj 0.018 Tw -15.55 -1.218 Td (\026\027\026\035\017\036 \()Tj /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.018 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,10\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033\013\017\036 \023\026\021\024\020\036\027\036\021\017\004\036\ \f\022\024\036 \024\002\024)Tj 0 Tw (-)Tj 0.169 Tw T* (\f\027\024\r\026\027\017\036 \(\022\035\017\027\017\022\024-\007\036\n\024\ \020\030\026\235\017\004\036\f\022\017\036 \b\026\030\026\022\021\036\030\ \017\f\021\017)Tj 0 Tw (-)Tj 0.03 Tw T* [(\022\017, \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\ \036 )0.5(\023\026\030\026\n\036\021\030\t, \n\026\030\022\036\030\t \024\022\f\017\ \007\026)]TJ 0 Tw (-)Tj 0.029 Tw T* (\021\017\r\027\024\020\024 \f\021\030\036\f\f\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\035\026\020\036\027\024\035\017\026, \200\207\212\). \200)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 )Tj 0.332 Tw T* (\023\024\001\026\020\024\r\024\020\024 \r\022\035\033\004\036\027\017\016\ \023\030\036\007\017\022\021\024\030\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\235\017\027\026\035\034\027\031\033 )Tj 0.289 Tw T* (\n\024\007\036\035\034 \r\024\001\035\017 \021\030\017 \027\036\026\r\017\ \f\017\n\t\b \235\026\022\021\024\030\026: \031\030\024\r\036\027\034 )Tj 0.063 Tw T* (\f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026, \204\212\202 \017)Tj /Span<>> BDC ( )Tj EMC (\200\207\212 \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 )Tj 0 Tw T* (\023\024\f\035\036 \024\023\036\030\026\006\017\017.)Tj 0.21 Tw T* (\200 \024\022\024\027\004\026\021\036\035\034\027\024\005 \n\024\007\036\ \035\017 \023\024\r\t\001\036\027\017\036 \022\024\027\006\036\027\021\030\ \026\006\017\017 )Tj 0.124 Tw T* (\f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026 \027\026)Tj /Span<>> BDC ( )Tj EMC (1 \n\022\n\024\035\034/\035 \026\f\f\024\006\017\017\030\024)Tj 0 Tw (-)Tj 0.172 Tw T* [(\r\026\035\024\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\031\r\036\035\017\004\036\027\017\036\n )0.5(\030\017\f\022\026 )0.5(\203\202 )0.5(\(\210\231 1,35; )0.5(95% \212\230 )]TJ 0 Tw T* (1,08\2261,69; )Tj /T1_1 1 Tf 4.527 0 Td (p)Tj /T1_0 1 Tf 0.057 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,009\). \212\035\016 \200\207\212 \022\026\032\007\t\036 \007\024\023\024\ \035\027\017\021\036\035\034)Tj 0 Tw (-)Tj 0.069 Tw -4.527 -1.218 Td (\027\t\036 1 \n\n \030\021. \f\021. \023\030\017\r\024\007\017\035\017 \022\ )Tj /Span<>> BDC ( )Tj EMC (\030\024\f\021\031 \001\026\027\f\024\r \027\036\f\024\f\021\024)Tj 0 Tw (-)Tj 0.077 Tw T* (\016\021\036\035\034\027\024\f\021\017 \026\027\026\f\021\024\n\024\026\ \(\210\231 1,35; 95% \212\230 1,10\2261,65; )Tj /T1_1 1 Tf 0 Tw 23.244 36.534 Td (p)Tj /T1_0 1 Tf 0.172 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\). \211\r\036\035\017\004\036\027\017\036 \031\030\024\r\027\016 \204\ \212\202 \027\026)Tj /Span<>> BDC ( )Tj EMC (1)Tj /Span<>> BDC ( )Tj EMC (\027\n\024\035\034/\n\035 )Tj 0.179 Tw T* (\021\026\022\032\036 \016\r\035\016\035\024\f\034 \027\036\026\r\017\f\017\ \n\t\n \023\030\036\007\017\022\021\024\030\024\n \203\202 \(\210\231 )Tj 0 Tw T* (2,86; 95% \212\230 1,25\2266,56; )Tj /T1_1 1 Tf (p)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,013\) \(\221\026\002\035. 2\).)Tj 0.277 Tw T* [(\200\022\035\033\004\036\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 6.083 0 Td [(\n\024\007\036\035\034 )0.5(\r\024\030\026\f\021\026, )0.5(\023\024\035\026, )0.5(\007\035\017\021\036\035\034\027\024\f\021\017 )]TJ 0.017 Tw -6.083 -1.218 Td (\024\023\036\030\026\006\017\017, \024\002\255\201\n\026 \022\030\024\r\024\ \023\024\021\036\030\017 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \022\035\017\027\017\022\024-\007\036)Tj 0 Tw (-)Tj T* (\n\024\020\030\026\235\017\004\036\f\022\017\b \023\026\030\026\n\036\021\ \030\024\r \027\036 \023\030\017\r\024\007\017\035\024 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\n\024)Tj (-)Tj T* (\n\031 \031\035\031\004\001\036\027\017\033 \022\026\004\036\f\021\r\026\ \n\024\007\036\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \f\024\023\030\024\r\024\032\007\026\035\024\f\034 )Tj 0.026 Tw T* [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\027\026\004\017\n\t\n )0.5(\r\022\035\026\007\024\n )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\017\f\022 )0.5(\203\202 )0.5(\()]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.026 Tw /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC 20.425 0 Td (0,05 )Tj 0.174 Tw -20.425 -1.218 Td (\007\035\016 \f\024\024\021\r\036\021\f\021\r\031\033\013\017\b \022\024\ \220\235\235\017\006\017\036\027\021\024\r\), \023\024\220\021\024\n\031\ \220\021\017 )Tj 0.321 Tw T* (\023\036\030\036\n\036\027\027\t\036 \002\t\035\017 \017\f\022\035\033\004\ \036\027\t \027\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\026\b \001\026\020\024\r\024\020\024 )Tj 0 Tw T* (\024\021\002\024\030\026.)Tj 0.3 Tw T* (\025\026\004\036\f\021\r\024 \017\021\024\020\024\r\024\005 \n\024\007\036\ \035\017 \002\t\035\024 \031\007\024\r\035\036\021\r\024\030\017\021\036\ \035\034)Tj 0 Tw (-)Tj -0.089 Tw T* [(\027\t\n: A)17(UC 0,93 \(95% \212\230 0,84\2260,98; )]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf -0.089 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\); \023\f\036\r\007\024-R\262 )Tj 0.072 Tw T* (\203\026\005\007\032\036\035\022\036\030\022\026 0,65; \021\036\f\021 \216\ \024\f\n\036\030\026\226\214\036\n\036\001\024\031 \245\262)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (9,0; )Tj /T1_1 1 Tf 0 Tw T* (p)Tj /T1_0 1 Tf 0.014 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34, \004\021\024 \f\r\017\007\036\021\036\035\034\f\021\r\031\036\021 \ \024)Tj /Span<>> BDC ( )Tj EMC (\b\024\030\024\001\036\n \f\024\020\035\026\f\017\017 \027\026)Tj 0 Tw (-)Tj T* (\002\035\033\007\026\036\n\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\022\026\026\027\027\t\b \r\036\030\024\016\021\027\024\ \f\021\036\005.)Tj 0.119 Tw T* (\212\035\016 \024\006\036\027\022\017 \023\030\024\020\027\024\f\021\017\ \004\036\f\022\024\005 \027\026\004\017\n\024\f\021\017 \024\021\007\036\ \035\034\027\t\b )Tj 0 Tw T* (\n\026\030\022\036\030\024\r \002\t\035 \023\030\024\r\036\007\201\027 )Tj /T1_1 1 Tf -0.019 Tc 0.019 Tw [(RO)-19(C)]TJ /T1_0 1 Tf 0 Tc 0 Tw 11.622 0 Td (-\026\027\026\035\017.)Tj -11.622 -1.218 Td (\215\030\017 )Tj /T1_1 1 Tf -0.019 Tc 0.019 Tw 2.233 0 Td [(RO)-19(C)]TJ /T1_0 1 Tf 0 Tc 0.379 Tw 1.469 0 Td (-\026\027\026\035\017\036 \031\030\024\r\036\027\034 \f\r\024\002\024\007\ \027\024\020\024 \024\022\f\017\023\030\024\035\017)Tj 0 Tw (-)Tj 0.158 Tw -3.702 -1.218 Td (\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC 2.729 0 Td [(2\2263-\017 \f\031\021\022\017 \023\024\f\035\036 )0.5(\024\023\036\030\026\006\017\017 \007\036\n\024\027\f\021\030\017\030\024\ \r\026\035 )]TJ 0.277 Tw -2.729 -1.218 Td (\b\024\030\024\001\031\033 \007\017\f\022\030\017\n\017\027\017\030\031\033\ \013\031\033 \f\023\024\f\024\002\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024)Tj 0 Tw (-)Tj 0.13 Tw T* [(\001\036\027\017\017 \203\202: A)17.1(UC 0,83 \(95% \212\230 0,72\2260,93; )]TJ /T1_1 1 Tf 0 Tw (p)Tj /T1_0 1 Tf 0.13 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj 0.259 Tw T* (\210\023\021\017\n\026\035\034\027\024\036 \023\024\030\024\020\024\r\024\ \036 \027\026\004\036\027\017\036)Tj /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (15,0 \n\022\n\024\035\034/\035 )Tj 0.193 Tw T* (\024\002\036\f\023\036\004\017\r\026\035\024 \004\031\r\f\021\r\017\021\036\ \035\034\027\024\f\021\034 79,1% \017)Tj /Span<>> BDC ( )Tj EMC (\f\023\036\006\017\235\017\004)Tj 0 Tw (-)Tj 0.181 Tw T* (\027\024\f\021\034 77,3%, \023\024\035\024\032\017\021\036\035\034\027\031\ \033 \023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\ )Tj 0 Tw (-)Tj 0.279 Tw T* (\027\024\f\021\034 \(\215\215\037\) 87,2% \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\017\006\026\021\036\035\034\027\031\033 \023\030\024\020\027\ \024\f\021\017\004\036)Tj 0 Tw (-)Tj 0.157 Tw T* (\f\022\031\033 \006\036\027\027\024\f\021\034 \(\210\215\037\) 65,4%, \024\ \002\013\031\033 \021\024\004\027\024\f\021\034 78,5% )Tj 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 0.315 Tw T* [(\212\017\026\020\027\024\f\021\017\004\036\f\022\026\016 )0.6(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.5(\f\r\024\002\024\007\027\024\020\024 )0.6(\024\022\f\017)]TJ 0 Tw (-)Tj 0.217 Tw T* (\023\030\024\035\017\027\026, \200\207\212 \017)Tj /Span<>> BDC ( )Tj EMC (\204\212\202 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\017 \203\202 \023\030\ \036\007)Tj 0 Tw (-)Tj 0.259 Tw T* (\f\021\026\r\035\036\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\021\026\002\035\017\006\036 3 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026 \030\017\f\031\027\022\036 1. \222\r\024\002\024\007\027\t\005 \ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.02 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \001\027\016\020\021\022\024\022\026\013\027 \033\032\027\030\022\n\023\ \031\032\013 \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\ \022 )0.5(\023\031\f\024\023\031\n\022\213\027\007\025\031\b\031 \020\025\020\024\023\ \031\026\031\016\020 \(\026\025\031\b\031\203\020\n\023\031\032\025\013\235\ \f\031\b\022\024\023\022\007\027)]TJ 0 Tw (-)Tj 0 -1.2 TD (\024\n\022\235 \032\027\b\032\027\024\024\022\031\025\025\013\235 \020\025\ \020\f\022\016\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.002 Tc -0.002 Tw 3.334 0 Td [( I)4.2(n)-2.8(d)-3.3(e)-5.7(p)-9.3(e)-5(n)-2.7(d)-3.3(e)-5(n)1.4(t)2( p)-0.8(re)-10.9(d)-1(ic)-30.4(t)-1(o)-0.9(r)-12.9(s)2( o)6(f)]TJ /Span<>> BDC 10.431 0 Td ( )Tj EMC [(c)4.8(o)-3.3(l)0.5(o)-2(n)3.6(ic)2( a)-3.1(n)2.4(a)-5.2(s)-12.8(t)-1(o)-2(m)-3.3(o)-0.8(t)-27.1(ic)2( s)8.7(u)-2.8(t)0.9(u)3.6(re)2( f)-6(a)-4.3(i)4.9(l)1.9(u)3.6(re)2( \()63.7(m)3(ul)7.3(t)-27.1(i)-0.9(v)8.3(a)-2.2(r)-37(i)3.5(a)-7.2(te)2( lo)-6.6(g)-16.7(i)8.6(s)-12.8(t)-27.1(ic)2( re)-5.7(g)0.5(re)-20(s)-8.5(s)-10.5(i)0.6(o)-2(n)2( a)-3.1(n)2.4(a)-2.5(l)8.6(y)-3.3(s)-10.4(i)8.6(s)70.2(\))]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 692.9117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 207.1791 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.8721 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 320.565 704.381 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 365.9193 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 704.381 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 479.3051 704.381 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 524.6594 693.1617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 681.6926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 206.9291 692.9117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 207.1791 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 263.8721 692.9117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 320.565 692.9117 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 365.9193 692.9117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 422.6122 692.9117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 479.3051 692.9117 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 681.6926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 681.4426 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.8721 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 681.4426 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 681.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 681.4426 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 670.2313 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 669.9813 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.8721 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 669.9813 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 669.9813 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 669.9813 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 658.77 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 658.52 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 71.1161 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 207.1791 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 207.1791 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.8721 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 320.565 658.52 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 320.565 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 365.9193 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 365.9193 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 422.6122 658.52 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 479.3051 658.52 cm 0 0 m 45.604 0 l S Q q 1 0 0 1 479.3051 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 647.3087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 647.0587 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 207.1791 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 263.8721 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 320.565 647.0587 cm 0 0 m 45.354 0 l S Q q 1 0 0 1 365.9193 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 422.6122 647.0587 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 479.3051 647.0587 cm 0 0 m 45.604 0 l S Q BT /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 8 0 0 8 119.2039 690.0118 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 15.704 0.717 Td (\017\240\b\002\226\004\220\003\002\006\b\013\005 \004\b\004\f\t\213)Tj 19.593 0 Td (\215\b\002\n\002\226\004\220\003\002\006\b\013\005 \004\b\004\f\t\213)Tj -21.487 -1.434 Td (\017\016)Tj 6.108 0 Td (95% \031\034)Tj /T1_3 1 Tf 7.827 0.001 Td (p)Tj /T1_2 1 Tf 5.907 -0.001 Td (\017\016)Tj 6.108 0 Td (95% \031\034)Tj /T1_3 1 Tf 7.827 0.001 Td (p)Tj /T1_0 1 Tf -53.244 -1.433 Td (\222\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\035\017\027,\ \n\022\n\024\035\034/\035)Tj 19.354 0 Td (1,50)Tj 5.966 0 Td (1,22\2261,85)Tj 6.882 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.994 0 Td (1,35)Tj 5.966 0 Td (1,08\2261,69)Tj 7.248 0 Td (0,009)Tj -52.411 -1.433 Td (\200\207\212, \n\n \030\021. \f\021.)Tj 19.354 0 Td (1,34)Tj 5.966 0 Td (1,14\2261,58)Tj 6.882 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.994 0 Td (1,35)Tj 5.966 0 Td (1,10\2261,65)Tj 7.248 0 Td (0,004)Tj -52.411 -1.433 Td (\204\212\202, \027\n\024\035\034/\n\035)Tj 19.354 0 Td (3,06)Tj 5.966 0 Td (1,61\2265,79)Tj 6.882 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj 6.994 0 Td (2,86)Tj 5.966 0 Td (1,25\2266,56)Tj 7.248 0 Td (0,013)Tj /T1_1 1 Tf 7 0 0 7 70.8661 635.574 Tm (\004\032\022\026\027\007\020\025\022\027: \217\237)Tj /Span<>> BDC ( )Tj EMC (\227 \031\023\025\031\213\027\025\022\027 \213\020\025\024\031\021; 95% \ \220\002)Tj /Span<>> BDC ( )Tj EMC [(\227 95% \030\031\021\027\032\022\023\027\f\017\025\013\235 \022\025\023\ \027\032\021\020\f \(\026\027\023\031\030)0.7( \211\020\f\017\030\020\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 616.2701 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \220\022\020\b\025\031\024\023\022\007\027\024\n\020\t \006\027\025\025\ \031\024\023\017 \033\031\n\020\016\020\023\027\f\027\235 \022)Tj /Span<>> BDC ( )Tj EMC [(\022\025\023\027\b\032\020\f\017\025\031\235 )0.5(\026\031\030\027\f\022 \021)]TJ /Span<>> BDC ( )Tj EMC (\033\032\031\b\025\031\016\022\032\031\021\020\025\022\022 \001\003 \(RO\ C-\020\025\020\f\022\016\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.318 0 Td [( D)-12.1(i)1.5(a)-5.1(g)-2.5(n)-2.4(o)-1(s)-14.8(t)-29.1(i)-1.8(c v)6.3(a)-4.5(lu)-3.2(e o)4.1(f i)3.9(n)-4.8(d)-3(i)-1.8(c)3.2(a)-9.1(t)-3(o)-3(r)-14.9(s a)-5.1(n)-4.8(d i)4(n)-0.6(t)-1.6(e)-7.7(g)-1.5(r)3.3(a)-4.5(l m)-5.3(o)-11.9(d)-5.3(e)-6.1(l i)3.9(n p)-2.8(r)-1.9(e)-13(d)-2.9(i)-1.8(c)-32.4(t)-29.1(i)3.9(n)-0.6(g a)-5.1(na)-7.1(s)-14.8(t)-3(o)-4(m)-5.3(o)-1.1(s)-12.5(i)6.6(s f)-8(a)-6.3(i)2.9(lu)1.6(r)-2(e \()30(RO)-11.7(C a)-5.1(na)-4.5(l)6.6(y)-5.3(s)-12.5(i)6.6(s)68.2(\))]TJ ET /GS2 gs q 1 0 0 1 70.8661 600.9681 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 600.9681 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 297.8878 600.9681 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 411.2736 600.9681 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 580.1489 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 579.8989 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 579.8989 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 579.8989 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 579.8989 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 568.6876 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 568.4376 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 568.4376 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 568.4376 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 568.4376 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 557.2263 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 556.9763 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 556.9763 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 556.9763 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 556.9763 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 545.765 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 545.515 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 545.515 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 545.515 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 545.515 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 534.3037 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 534.0537 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 534.0537 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 534.0537 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 534.0537 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 522.8425 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 522.5925 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 522.5925 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 522.5925 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 522.5925 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 511.3812 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 511.1312 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 71.1161 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 511.1312 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 184.502 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 297.8878 511.1312 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 411.2736 511.1312 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 411.2736 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 499.9199 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 499.6699 cm 0 0 m 113.636 0 l S Q q 1 0 0 1 184.502 499.6699 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 297.8878 499.6699 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 411.2736 499.6699 cm 0 0 m 113.636 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 107.8653 587.5335 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 11.317 0.6 Td (\255\002\206\002\240\b\013\005 \002\220\217\t\212\006\002\f\t\b, )Tj 3.218 -1.2 Td (\214\220\214\002\f\001/\f)Tj 13.124 0.6 Td (\026\224\031, \214\214 \006\003. \217\003.)Tj 14.003 0 Td (\215\031\032, \b\214\002\f\001/\214\f)Tj /T1_0 1 Tf -45.902 -2.033 Td (\215\024\030\024\020)Tj 17.955 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC (15 \n\022\n\024\035\034/\035)Tj 14.192 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC (15 \n\n \030\021. \f\021.)Tj 14.037 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC (4,0 \027\n\024\035\034/\n\035)Tj -46.184 -1.433 Td (AUC \(95% \212\230\))Tj 17.614 0 Td (0,83)Tj /Span<>> BDC ( )Tj EMC (\(0,72\2260,93\))Tj 14.173 0 Td (0,78)Tj /Span<>> BDC ( )Tj EMC (\(0,65\2260,90\))Tj 14.173 0 Td (0,80)Tj /Span<>> BDC ( )Tj EMC (\(0,68\2260,91\))Tj -45.96 -1.433 Td (\232\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034, %)Tj 20.063 0 Td (79,1)Tj 14.173 0 Td (69,8)Tj 14.173 0 Td (74,4)Tj -48.409 -1.433 Td (\222\023\036\006\017\235\017\004\027\024\f\021\034, %)Tj 20.063 0 Td (77,3)Tj 14.173 0 Td (72,7)Tj 14.173 0 Td (77,3)Tj -48.409 -1.433 Td (\215\215\037, %)Tj 20.063 0 Td (87,2)Tj 14.173 0 Td (83,3)Tj 14.173 0 Td (86,5)Tj -48.409 -1.433 Td (\210\215\037, %)Tj 20.063 0 Td (65,4)Tj 14.173 0 Td (55,2)Tj 14.173 0 Td (60,7)Tj -48.409 -1.433 Td (\221\024\004\027\024\f\021\034, %)Tj 20.063 0 Td (78,5)Tj 14.173 0 Td (70,8)Tj 14.173 0 Td (75,4)Tj /T1_1 1 Tf 7 0 0 7 70.8661 488.1852 Tm (\004\032\022\026\027\007\020\025\022\027: \004\031\032\031\b\031\021\013\ \027 \016\025\020\007\027\025\022\t \021\013\240\032\020\025\013 \033\031\ )Tj /Span<>> BDC ( )Tj EMC [(\022\025\030\027\n\024\r \224\030\027\025\020. A)29.5(UC)]TJ /Span<>> BDC ( )Tj EMC [(\227 \033\f\031\212\020\030\017 \033\031\030 R)19.2(OC-\n\032\022\021\031\235, \004\004\037)]TJ /Span<>> BDC ( )Tj EMC (\227 \033\031\f\031\255\022\023\027\f\017\025\020\t \033\032\031\b\025\031\ \024\023\022\007\027\024\n\020\t \006\027\025\025\031\024\023\017; \217\004\ \037)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0 -1.2 TD [(\031\023\032\022\006\020)49.1(\023\027\f\017\025\020\t \033\032\031\b\025\031\024\023\022\007\027\024\n\ \020\t \006\027\025\025\031\024\023\017. 95% \220\002 \030\f\t \007\r\021\ \024\023\021\022\023\027\f\017\025\031\024\023\022, \024\033\027\006\022\ \203\022\007\025\031)0.6(\024\023\022, \004\004\037, \217\004\037 \022)]TJ /Span<>> BDC ( )Tj EMC (\023\031\007\025\031\024\023\022 \032\020\024\024\007\022\023\020\025\013\ \033\031)Tj /Span<>> BDC ( )Tj EMC (\026\027\023\031\030\r \202\f\031\033\033\027\032\020-)Tj T* (\004\022\032\024\031\025\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1274 56.0378 Tm (96)Tj ET endstream endobj 982 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 983 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 984 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 985 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 986 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1056 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.844 Tw 10 0 0 10 42.5197 469.0919 Tm [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\r\001\017\036\ )0.6(\026\f\f\024\006\017\026\006\017\033 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.645 0 Td (\017\f\b\024\007\024\n )Tj 0.18 Tw -18.645 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\235\026\022\021\024\030\027\024\n \026\027\026\035\017\ \036 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.18 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,10\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\n\036\033\013\017\036 )Tj 0.506 Tw 0 -1.218 TD (\023\026\021\024\020\036\027\036\021\017\004\036\f\022\024\036 \024\002\024\ \f\027\024\r\026\027\017\036 \(\022\035\017\027\017\022\024-\007\036\n\024\ \020\030\026)Tj 0 Tw (-)Tj 0.318 Tw T* (\235\017\004\036\f\022\017\036 \b\026\030\026\022\021\036\030\017\f\021\017\ \022\017, \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\ \036 \023\026)Tj 0 Tw (-)Tj 0.147 Tw T* [(\030\026\n\036\021\030\t, \023\024\022\026\026\021\036\035\017 )0.5(\024\022\f\017\007\026\021\017\r\027\024\020\024 \f\021\030\036\f\f\026,\ \n\026\030\022\036)]TJ 0 Tw (-)Tj 0.344 Tw T* (\030\t \007\036\020\030\026\007\026\006\017\017 \022\024\035\035\026\020\ \036\027\026, \200\207\212\). \204\027\024\020\024\235\026\022\021\024\030\ \027\031\033 )Tj 0.511 Tw T* (\n\024\007\036\035\034 \f\021\030\024\017\035\017 \n\036\021\024\007\024\ \n \023\024\001\026\020\024\r\024\020\024 \r\022\035\033\004\036\027\017\ \016 )Tj 0.182 Tw T* [(\023\030\036\007\017\022\021\024\030\024\r \(for)-37.9(w)-12(ar)-24(d step)-17(wise\). \025\026\004\036\f\021\r\024 \017\021\024\020\024\r\024\005 )]TJ 0.385 Tw T* (\023\030\024\020\027\024\f\021\017\004\036\f\022\024\005 \n\024\007\036\035\ \017 \024\006\036\027\017\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\f\036\r\007\024-R\262 )Tj 0.951 Tw T* (\203\026\005\007\032\036\035\022\036\030\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036\030\017\033 \216\024\f\n\036\030\026\226\214\036\n\036\ \001\024\031. )Tj 0.181 Tw T* (\215\030\024\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\ \024\f\021\034 \024\021\007\036\035\034\027\t\b \022\024\035\017\004\036\ \f\021\r\036\027)Tj 0 Tw (-)Tj 0.124 Tw T* (\027\t\b \023\024\022\026\026\021\036\035\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\020\030\026\035\034\027\024\005 \n\024\007\036\035\017 \ \024\006\036\027\017\r\026\035\017 )Tj -0.019 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 )Tj /T1_2 1 Tf -0.019 Tc 0.019 Tw [(RO)-19(C)]TJ /T1_1 1 Tf 0 Tc -0.019 Tw 6.197 0 Td (-\026\027\026\035\017\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\004\201\021\024\n \023\035\024\013\026\007\017 \023\024\007 )Tj /T1_2 1 Tf -0.019 Tc 0.019 Tw [(RO)-19(C)]TJ /T1_1 1 Tf 0 Tc 0 Tw 15.561 0 Td (-)Tj 0.209 Tw -21.758 -1.218 Td [(\022\030\017\r\024\005 \(A)17.1(UC\), 95% \212\230 \017)]TJ /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.209 Tw (-\027\026\004\036\027\017\016. \210\023\021\017\n\026\035\034\027\t\036\ )Tj 0.088 Tw T* [(\023\024\030\024\020\024\r\t\036 )0.5(\027\026\004\036\027\017\016 )0.6(\024\023\030\036\007\036\035\016\035\017 )0.6(\023\024)]TJ /Span<>> BDC ( )Tj EMC 15.424 0 Td [(\017\027\007\036\022\f\031 )0.5(\224\007\036\027\026. )]TJ 0.145 Tw -15.424 -1.218 Td (\212\035\016 \r\t\002\030\026\027\027\t\b \023\024\030\024\020\024\r \030\ \026\f\f\004\017\021\t\r\026\035\017 \004\031\r\f\021\r\017\021\036\035\034\ )Tj 0 Tw (-)Tj 0.036 Tw T* (\027\024\f\021\034 \(Se\), \f\023\036\006\017\235\017\004\027\024\f\021\034\ \(Sp\), \023\024\035\024\032\017\021\036\035\034\027\031\033 \023\030\024\ )Tj 0 Tw (-)Tj 0.067 Tw T* (\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\024\f\021\034\ \(\215\215\037\) \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\017\006\026\021\036\035\034\027\031\033 \023\030\024)Tj 0 Tw (-)Tj 0.259 Tw T* (\020\027\024\f\021\017\004\036\f\022\031\033 \006\036\027\027\024\f\021\034\ \(\210\215\037\) \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\004\017\f\035\036\027\017\036\n 95% )Tj 0.152 Tw T* (\212\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \025\035\024\023\023\036\030\026\226\215\017\030\f\ \024\027\026. \215\030\024\020\027\024\f\021\017\004\036\f\022\017\036 )Tj 0.594 Tw T* (\b\026\030\026\022\021\036\030\017\f\021\017\022\017 \017\027\021\036\020\ \030\026\035\034\027\024\005 \n\024\007\036\035\017 \024\006\036\027\017\ \r\026\035\017 )Tj 0.103 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\036\027\017\016\n \023\030\036\007\f\022\026\026\027\027\024\ \005 \r\036\030\024\016\021\027\024\f\021\017 \203\202, \023\024\035\031\ )Tj 0 Tw (-)Tj 0.289 Tw T* (\004\036\027\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\235\026\022\021\024\030\027\024\005 \035\024\020\017\f\ \021\017\004\036\f\022\024\005 \030\036\020\030\036\f)Tj 0 Tw (-)Tj 0.248 Tw T* (\f\017\017. \222\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\ \017\n\t\n\017 \f\004\017\021\026\035\017 \030\036\031\035\034\021\026\021\ \t )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 140.2859 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.388 Tw 10 0 0 10 42.5197 115.9299 Tm (\200 \017\f\f\035\036\007\024\r\026\027\017\036 \r\022\035\033\004\036\027\ \t 65 \023\026\006\017\036\027\021\024\r, \017)Tj /Span<>> BDC ( )Tj EMC (\027\017\b )Tj 0.007 Tw T* (37)Tj /Span<>> BDC ( )Tj EMC [(\(56,9%\) )0.5(\n\031\032\004\017\027 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.833 0 Td (28)Tj /Span<>> BDC ( )Tj EMC [(\(43,1%\) \032\036\027\013\017\027. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC 9.326 0 Td (\024\f\027\024\r\027\024\005 )Tj 0.175 Tw -18.159 -1.218 Td (\020\030\031\023\023\036 \(\203\202\) \002\t\035\024 25)Tj /Span<>> BDC ( )Tj EMC (\(58,1%\) \n\031\032\004\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (18)Tj /Span<>> BDC ( )Tj EMC (\(41,9%\) )Tj 0.71 Tw T* (\032\036\027\013\017\027; \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 12 \(54,5%\) )Tj 0.061 Tw 23.244 38.97 Td (\017)Tj /Span<>> BDC ( )Tj EMC (10)Tj /Span<>> BDC ( )Tj EMC (\(45,5%\), \f\024\024\021\r\036\021\f\021\r\036\027\027\024, \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.061 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,99\). \200\024\030\026\f\021 \023\026)Tj 0 Tw (-)Tj 0.122 Tw T* (\006\017\036\027\021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \027\026\004\017\n\024 \027\036 \030\026\035\ \017\004\026\035\f\016: \n\036\007\017\026\027\026 )Tj 0.033 Tw T* [(\(Me )0.5([Q1\226Q3]\) )0.6(\f\024\f\021\026\r\017\035\026 )0.5(63,0 )0.6([57,4\22669,0] )0.5(\020\024\007\026 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 19.94 0 Td (\020\030\031\023)Tj 0 Tw (-)Tj 0.102 Tw -19.94 -1.218 Td (\023\036 \203\202 \017)Tj /Span<>> BDC ( )Tj EMC (61,2)Tj /Span<>> BDC ( )Tj EMC ([56,9\22670,0] \020\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \002\036 \027\036\f\024)Tj 0 Tw (-)Tj T* (\f\021\024\016\021\036\035\034\027\024\f\021\017 \()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,91\).)Tj 0.311 Tw T* [(\212\035\017\021\036\035\034\027\024\f\021\034 )0.5(\024\023\036\030\026\006\017\017 \002\t\035\026 \f\024\023\024\f\021\026\ \r\017\n\024\005: )0.5(144,9 )]TJ 0.152 Tw T* ([132,3\226155,1] \n\017\027. \023\030\024\021\017\r 136,3 [124,8\226150,\ 2] \n\017\027. )Tj 0 Tw T* (\()Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf 0.114 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,182\), \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n \017\027\021\030\026\024\023\036\030\026\006\017\024\027\ \027\024\005 \022\030\024\r\024)Tj 0 Tw (-)Tj 0.131 Tw T* (\023\024\021\036\030\017)Tj /Span<>> BDC ( )Tj EMC 3.231 0 Td [(\227 )0.5(280 )0.5([222,7\226337,3] )0.6(\n\035 )0.5(\023\030\024\021\017\r )0.6(260 )0.5([207,4\226)]TJ 0.301 Tw -3.231 -1.218 Td (312,6] \n\035 \()Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.301 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,360\). \221\026\022\017\n \024\002\030\026\024\n, \020\030\031\023\023\ \t \027\036 )Tj 0.077 Tw T* (\024\021\035\017\004\026\035\017\f\034 \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\f\027\024\r\027\t\n \002\026\024\r\t\n \022\035\017\027\017\022\024\ -\007\036\n\024\020\030\026)Tj 0 Tw (-)Tj 0.405 Tw T* [(\235\017\004\036\f\022\017\n )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.901 0 Td [(\017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\n )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022\026\n )]TJ 0 Tw -5.901 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.121 Tw T* (\211\030\024\r\036\027\034 \204\212\202 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \f\024\f\021\026\r\017\035 4,4 [3,9\2264,7] )Tj 0.268 Tw T* (\027\n\024\035\034/\n\035, \004\021\024 \002\t\035\024 \f\031\013\036\f\021\ \r\036\027\027\024 \r\t\001\036, \004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (\023\026)Tj 0 Tw (-)Tj 0.122 Tw T* (\006\017\036\027\021\024\r \002\036 \203\202 \(3,1 [2,4\2263,6] \027\n\024\ \035\034/\n\035; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.122 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\). )Tj -0.036 Tw T* (\025\024\027\006\036\027\021\030\026\006\017\016 \007\017\036\027\024\r\t\ \b \022\024\027\255\033\020\026\021\024\r \(\212\025\) \021\026\022\032\036\ \002\t\035\026 )Tj 0.284 Tw T* (\027\026\004\017\021\036\035\034\027\024 \023\024\r\t\001\036\027\026 \r\ )Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \203\202 \(3,1 [2,8\2263,4] )Tj 0.107 Tw T* [(\023\030\024\021\017\r )0.5(1,9 [1,7\2262,1] )0.5(\n\n\024\035\034/\n\035; )]TJ /T1_2 1 Tf 0 Tw 13.441 0 Td (p)Tj /T1_1 1 Tf 0.107 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC 1.657 0 Td [(0,001\), \021\024\020\007\026 )0.5(\022\026\022 )]TJ 0.25 Tw -15.098 -1.218 Td (\031\030\024\r\036\027\034 \026\f\022\024\030\002\017\027\024\r\024\005 \ \022\017\f\035\024\021\t \024\022\026\026\035\f\016 \f\021\026\021\017\f\ \021\017)Tj 0 Tw (-)Tj 0.244 Tw T* (\004\036\f\022\017 \027\026\004\017\n\024 \027\017\032\036 \(52,4 [47,6\ \22656,4] \023\030\024\021\017\r 65,5 )Tj 0 Tw T* ([59,7\22670,4] \n\n\024\035\034/\035; )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\).)Tj 0.295 Tw T* (\211 \002\024\035\034\027\t\b \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 \030\036\020\017\f\021\030\017\030\024\r\026\035\024\f\034 \002\ \024\035\036\036 \r\t\f\024\022\024\036 )Tj 0.203 Tw T* (\f\024\007\036\030\032\026\027\017\036 \035\026\022\021\026\021\026 \(2,\ 7 [2,3\2263,1] \023\030\024\021\017\r 1,6 [1,4\226)Tj 0.13 Tw T* (1,8] \n\n\024\035\034/\035; )Tj /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf 0.13 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \017)Tj /Span<>> BDC ( )Tj EMC (\f\r\024\002\024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\ \026 )Tj 0.15 Tw T* (\(18,0 [15,7\22619,6] \023\030\024\021\017\r 12,7 [11,1\22614,8] \n\022\n\ \024\035\034/\035; )Tj /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.287 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \026)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\006\036\027\021\030\026\006\017\016 \f\036\030\024\021\024\027\ \017\027\026, \027\026\023\030\024\021\017\r, )Tj 0.357 Tw T* (\002\t\035\026 \f\027\017\032\036\027\026 \(0,6 [0,5\2260,7] \023\030\024\ \021\017\r 0,9 [0,8\2260,9] )Tj 0 Tw T* (\n\022\n\024\035\034/\035; )Tj /T1_2 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\).)Tj 0.217 Tw T* (\200\027\031\021\030\017\002\030\033\001\027\024\036 \007\026\r\035\036\027\ \017\036 \(\200\207\212\) \031)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r \f)Tj /Span<>> BDC ( )Tj EMC (\203\202 )Tj 0.066 Tw T* [(\007\024\f\021\017\020\026\035\024 )0.5(16,1 [14,2\22617,9] )0.5(\n\n \030\021. )0.5(\f\021. )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 16.53 0 Td [(\027\026\004\017\n\024 )0.5(\023\030\036)]TJ 0 Tw (-)Tj 0.114 Tw -16.53 -1.218 Td (\r\t\001\026\035\024 \f\024\024\021\r\036\021\f\021\r\031\033\013\017\005\ \023\024\022\026\026\021\036\035\034 \031)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\027\t\b \002\036 )Tj 0.23 Tw T* [(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.5(\026\027\026\f\021\024\n\024\026 \(10,5 [8,8\22615,1]] \n\n )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.045 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \202\f\022\025\022\007\027\024\n\022\027 \022)Tj /Span<>> BDC ( )Tj EMC (\f\020\240\031\032\020\023\031\032\025\013\027 \200\020\032\020\n\023\027\ \032\022\024\023\022\n\022 \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\017\005 \023\ \031\f\024\023\031\n\022\213\027\007\025\031\b\031 \020\025\020\024\023\031\ )Tj 0 Tw (-)Tj 0 -1.2 TD (\026\031\016\020 \022)Tj /Span<>> BDC ( )Tj EMC (\240\027\016 \025\027\233 \(\031\030\025\031\203\020\n\023\031\032\025\013\ \235 \020\025\020\f\022\016\), Me [Q1\231Q3])Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.017 Tc -0.029 Tw T* [(\020a)-25.3(b)-30.8(l)-28.7(e)-17( 1)-14.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.046 Tw 3.288 0 Td [( C)1.2(li)3.9(n)1.7(i)-1.8(c)3.2(a)-4.5(l a)-5.1(n)-4.8(d l)-1.1(a)-0.9(b)-10.1(o)-3(r)3.3(a)-9.2(t)-3(o)-3(r)-43.7(y c)-2.5(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.7(s)-14.9(t)-29(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s w)-26.7(i)-3.4(t)-10.5(h a)-5(n)-4.9(d w)-26.7(i)-3.4(t)-10.6(h)-2.4(o)-3.4(u)-4.8(t c)2.8(o)-5.3(l)-1.6(o)-3(r)-2(e)-10.8(c)-32.4(t)-2(a)-4.5(l a)-5.1(na)-7.2(s)-14.8(t)-3(o)-4(m)-5.2(o)-2.9(t)-29.1(i)-1.8(c le)-7.5(a)-2.7(k)11.3(a)-5.2(g)-6.8(e \()64.8(u)0.7(n)1.6(i)-2.8(v)6.3(a)-4.2(r)-39(i)1.5(a)-9.2(t)-1.6(e a)-5.1(na)-4.5(l)6.7(y)-5.3(s)-12.5(i)6.6(s)68.2(\))29.3(, )]TJ -0.065 Tc 0.065 Tw -3.288 -1.2 Td [(M)-67(e)-65( [)-21.3(Q)-47.3(1)-25.5(\231)-102.1(Q)-65.5(3])]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 212.8484 693.581 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 326.2343 693.581 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 693.581 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 682.3618 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 682.1118 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 670.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 682.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 682.1118 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 682.1118 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 670.9005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 670.6505 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 670.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 670.6505 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 670.6505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 659.4392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 659.1892 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 659.1892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 659.1892 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 659.1892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 647.9779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 647.7279 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 647.7279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 647.7279 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 647.7279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 636.5167 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 636.2667 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 636.2667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 636.2667 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 636.2667 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 625.0554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 624.8054 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 624.8054 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 624.8054 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 624.8054 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 613.5941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 613.3441 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 602.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 613.3441 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 613.3441 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 613.3441 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 496.313 602.1328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 601.8828 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 601.8828 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 601.8828 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 601.8828 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 590.6715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 590.4215 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 590.4215 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 590.4215 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 590.4215 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 579.2102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 578.9602 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 578.9602 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 578.9602 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 578.9602 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 567.749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 567.499 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 567.499 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 567.499 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 567.499 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 556.2877 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 556.0377 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 556.0377 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 556.0377 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 556.0377 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 544.8264 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 544.5764 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 544.5764 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 544.5764 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 544.5764 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 533.3651 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 533.1151 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 42.7697 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 533.1151 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 212.8484 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 533.1151 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 533.1151 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 521.9038 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 521.6538 cm 0 0 m 170.329 0 l S Q q 1 0 0 1 212.8484 521.6538 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 326.2343 521.6538 cm 0 0 m 113.386 0 l S Q q 1 0 0 1 439.6201 521.6538 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 8 0 0 8 107.8653 684.9464 Tm (\200\002\220\004\213\004\003\r\f\001)Tj 17.712 0 Td (\025\032 \()Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj 11.2 0 Td (\224\r\213 \002\217\f\002\202\b\r\b\t\005 \()Tj /T1_5 1 Tf (n)Tj /T1_4 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (22\))Tj /T1_5 1 Tf 14.52 0 Td (p)Tj /T1_4 1 Tf (-value)Tj /T1_1 1 Tf -51.215 -1.433 Td (\215\024\035\024\r\024\030\026\f\021\027\t\036 \b\026\030\026\022\021\036\ \030\017\f\021\017\022\017)Tj 0 -1.433 TD (\200\024\030\026\f\021, \035\036\021)Tj 24.7 0 Td (63,0 [57,4\22669,0])Tj 14.173 0 Td (61,2 [56,9\22670,0])Tj 12.829 0 Td (0,914)Tj -51.703 -1.433 Td (\204\031\032\004\017\027\t, )Tj /T1_2 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 26.163 0 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(58,1\))Tj 14.173 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(54,5\))Tj 11.366 0 Td (0,797)Tj -51.703 -1.433 Td (\230\027\021\030\026\024\023\036\030\026\006\017\024\027\027\t\036 \023\024\ \022\026\026\021\036\035\017)Tj T* (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017, \n\017\027.)Tj 23.95 0 Td (144,9 [132,3\226155,1])Tj 14.173 0 Td (136,3 [124,8\226150,2])Tj 13.579 0 Td (0,182)Tj -51.703 -1.433 Td (\025\030\024\r\024\023\024\021\036\030\016, \n\035)Tj 24.293 0 Td (280 [222,7\226337,3])Tj 14.173 0 Td (260 [207,4\226312,6])Tj 13.237 0 Td (0,360)Tj -51.703 -1.433 Td (\214\026\002\024\030\026\021\024\030\027\t\036 \023\024\022\026\026\021\ \036\035\017 \(2\2263-\017 \f\031\021\022\017\))Tj T* (\204\212\202, \027\n\024\035\034/\n\035)Tj 25.45 0 Td (4,4 [3,9\2264,7])Tj 14.173 0 Td (3,1 [2,4\2263,6])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\212\017\036\027\024\r\t\036 \022\024\027\255\033\020\026\021\t, \n\n\024\ \035\034/\n\035)Tj 25.45 0 Td (3,1 [2,8\2263,4])Tj 14.173 0 Td (1,9 [1,7\2262,1])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\202\f\022\024\030\002\017\027\024\r\026\016 \022\017\f\035\024\021\026,\ \n\022\n\024\035\034/\035)Tj 24.7 0 Td (52,4 [47,6\22656,4])Tj 14.173 0 Td (65,1 [59,7\22670,4])Tj 12.463 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\214\026\022\021\026\021, \n\n\024\035\034/\035)Tj 25.45 0 Td (2,7 [2,3\2263,1])Tj 14.173 0 Td (1,6 [1,4\2261,8])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\222\r\024\002\024\007\027\t\005 \024\022\f\017\023\030\024\035\017\027,\ \n\022\n\024\035\034/\035)Tj 24.7 0 Td (18,0 [15,7\22619,6])Tj 14.173 0 Td (12,7 [11,1\22614,8])Tj 12.463 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\222\036\030\024\021\024\027\017\027, \n\022\n\024\035\034/\035)Tj 25.45 0 Td (0,6 [0,5\2260,7])Tj 14.173 0 Td (0,9 [0,8\2260,9])Tj 11.713 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj -51.336 -1.433 Td (\200\207\212, \n\n \030\021. \f\021.)Tj 24.7 0 Td (16,1 [14,2\22617,9])Tj 14.423 0 Td (10,5 [8,8\22615,1])Tj 12.213 0 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,001)Tj /T1_2 1 Tf 7 0 0 7 42.5197 510.1691 Tm (\004\032\022\026\027\007\020\025\022\027: p)Tj /Span<>> BDC ( )Tj EMC (\227 \033\031)Tj /Span<>> BDC ( )Tj EMC [(U-\n\032\022\023\027\032\022\005 \215\020\025\025\020\231\210)50.3(\022\023\025\022 \030\f\t \n\031\f\022\007\027\024\023\021\027\025\025\013\ \200 \033\032\022\016\025\020\n\031\021 \022)]TJ /Span<>> BDC ( )Tj EMC (\250\262-\n\032\022\023\027\032\022\005 \004\022\032\024\031\025\020 \(\033\ \032\022 \025\027\031\240\200\031\030\022\026\031\024\023\022)Tj /Span<>> BDC ( )Tj EMC (\227 \023\031\007\025\031\026\r \n\032\022\023\027\032\022\005 )Tj 0 -1.2 TD (\214\022\213\027\032\020\) \030\f\t \n\020\007\027\024\023\021\027\025\025\ \013\200 \033\032\022\016\025\020\n\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.7895 56.0378 Tm (95)Tj ET endstream endobj 1055 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf -0.023 Tw 10 0 0 10 70.8661 724.8299 Tm (\022\024\035\035\026\020\036\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\016 \r\027\031\021\030\017\002\030\033\001\027\024\020\ \024 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027)Tj 0 Tw (-)Tj 0.052 Tw 0 -1.218 TD [(\027\036\005 )0.5(\007\017\026\020\027\024\f\021\017\022\036 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\021\024\035\f\021\024\022\017\001\036\004\027\t\b )]TJ 0 Tw T* (\026\027\026\f\021\024\n\024\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 70.936 663.9399 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 2.106 Tw 10 0 0 10 70.8661 639.5839 Tm (\200\t\023\024\035\027\036\027\024 \030\036\021\030\024\f\023\036\022\021\ \017\r\027\024\036 \024\002\f\036\030\r\026\006\017\024\027)Tj 0 Tw (-)Tj 0.727 Tw T* (\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \253\f\035\031\004\026\005-\022\024\027\021\030\024\035\ \034\273. )Tj 0.213 Tw T* [(\215\030\024\026\027\026\035\017\017\030\024\r\026\027\t )0.5(\017\f\021\024\030\017\017 \002\024\035\036\027\017 65 \023\026\006\017\ \036\027\021\024\r, )]TJ 0.1 Tw 0 -1.218 TD (\023\036\030\036\027\036\f\001\017\b \023\035\026\027\024\r\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\f\030\024\004\036\027\027\t\036 \030\036\036\022\006\017\017 \021\ \024\035)Tj 0 Tw (-)Tj -0.049 Tw 0 -1.218 TD (\f\021\024\005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \023\036\030\r\017\004\027\ \024\020\024 \026\027\026\f\021\024\n\024\026 )Tj 0.021 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\r\024\007\031 \007\024\002\030\024\022\026\004\036\f\021\r\036\027\ \027\t\b )0.5(\026\002\024\035\036\r\026\027\017\005 \(\007\024\035\017\b\024)]TJ 0 Tw (-)Tj 0.222 Tw T* (\f\017\020\n\026, \007\024\035\017\b\024\022\024\035\024\027, \n\036\020\ \026\007\024\035\017\b\024\f\017\020\n\026, \007\024\035\017\b\024\f\017\ \020\n\026 )Tj 0.089 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\f\024\004\036\021\026\027\017\036\n \f\017\027\007\030\024\n \215\026\005\ \030\026 \017)Tj /Span<>> BDC ( )Tj EMC (\021.\007.\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \035\017\022\r\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\007\026\006\017\017 \021\024\035\f\021\024\022\017\001\036\004\027\t\b \ \f\021\024\n \026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 2021\2262025 \020\020.)Tj 0 -1.218 TD (\025\030\017\021\036\030\017\017 \r\022\035\033\004\036\027\017\016:)Tj 0 -1.218 TD (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\r\024\030\026\f\021 \f\021\026\030\001\036 18 \035\036\021;)Tj -0.01 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-277( )]TJ EMC 1.056 0 Td (\030\036\036\022\006\017\016 \024\002\024\007\024\004\027\024\005 \022\017\ \001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\036\n \026\027\026)Tj 0 Tw (-)Tj 0.261 Tw T* (\f\021\024\n\024\026 \253\022\024\027\036\006-\r-\022\024\027\036\006\273\ \017\035\017 \253\002\024\022-\r-\002\024\022\273, \035\017\002\024 )Tj 0.118 Tw T* (\035\017\022\r\017\007\026\006\017\016 \022\024\035\024\f\021\024\n\t \f\ )Tj /Span<>> BDC ( )Tj EMC (\027\026\035\024\032\036\027\017\036\n \021\024\035\f\021\024-\021\024\035\ )Tj 0 Tw (-)Tj T* (\f\021\024\022\017\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\ \026;)Tj 0.506 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )239( )]TJ EMC 1.056 0 Td (\007\024\002\030\024\022\026\004\036\f\021\r\036\027\027\t\005 \b\026\030\ \026\022\021\036\030 \026\002\024\035\036\r\026\027\017\016 \(\024\021)Tj 0 Tw (-)Tj 0.11 Tw T* (\f\031\021\f\021\r\017\036 \022\024\035\024\030\036\022\021\026\035\034\027\ \024\020\024 \030\026\022\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\031\020\017\b \035\024\022\026\004\036)Tj 0 Tw (-)Tj T* (\f\021\r\036\027\027\t\b \027\024\r\024\024\002\030\026\024\r\026\027\017\ \005\);)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\017\027\235\024\030\n\017\030\024\r\026\027\027\024\036 \f\024\020\035\026\ \f\017\036 \023\026\006\017\036\027\021\026.)Tj -1.056 -1.218 Td (\025\030\017\021\036\030\017\017 \017\f\022\035\033\004\036\027\017\016:\ )Tj 0.081 Tw T* (\226)Tj /Span<>> BDC [( )-186( )]TJ EMC 1.056 0 Td [(\035\024\022\026\004\036\f\021\r\036\027\027\t\036 )0.6(\027\024\r\024\024\002\030\026\024\r\026\027\017\016 )0.6(\(\007\035\016 )0.5(\017\f\022\035\033\004\036)]TJ 0 Tw (-)Tj T* (\027\017\016 \023\026\030\026\027\036\024\023\035\026\f\021\017\004\036\f\ \022\024\020\024 \r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\n\026\030\022\036\030\t\);)Tj -0.059 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-326( )]TJ EMC 1.056 0 Td [(\030\026\f\023\030\024\f\021\030\026\027\201\027\027\t\005 )0.5(\023\036\030\017\021\024\027\017\021 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021 \024\023\036\030\026\006\017\017;)Tj 0.029 Tw -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-238( )]TJ EMC 1.056 0 Td (\021\016\032\201\035\t\036 \f\024\023\031\021\f\021\r\031\033\013\017\036\ \026\002\024\035\036\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\007\017\017 \007\036)Tj 0 Tw (-)Tj T* (\022\024\n\023\036\027\f\026\006\017\017, \f\031\013\036\f\021\r\036\027\ \027\024 \r\035\017\016\033\013\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024;)Tj -1.056 -1.218 Td (\226)Tj /Span<>> BDC [( )-267( )]TJ EMC 1.056 0 Td (\024\021\f\031\021\f\021\r\017\036 \022\035\033\004\036\r\t\b \035\026\002\ \024\030\026\021\024\030\027\t\b \023\024\022\026\026\021\036\035\036\005\ .)Tj 0.06 Tw -1.056 -1.218 Td (\215\026\006\017\036\027\021\t \002\t\035\017 \030\026\007\036\035\036\027\ \t \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\r\036 \020\030\031\023\023\t. \210\f\027\024\r\027\031\033 )Tj 0.167 Tw T* (\020\030\031\023\023\031 \f\024\f\021\026\r\017\035\017 43 \023\026\006\017\ \036\027\021\026, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n )Tj 0.115 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036 \(\007\024 14-\b \f\031\021\024\022\) \030\026\r\017\ )Tj 0 Tw (-)Tj 0.182 Tw T* (\035\026\f\034 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\ \034 \021\024\035\f\021\024\022\017\001\036\004\027\024\020\024 \026\027\ \026\f\021\024\n\024)Tj 0 Tw (-)Tj 0.004 Tw T* (\026. \212\026\027\027\t\005 \007\017\026\020\027\024 \002\t\035 \r\036\ \030\017\235\017\006\017\030\024\r\026\027 \022\035\017\027\017\004\036\f\ \022\017, )Tj 0.094 Tw T* [(\030\036\027\021\020\036\027\024\035\024\020\017\004\036\f\022\017 )0.6(\(\r\t\b\024\007 )0.5(\022\024\027\021\030\026\f\021\026\), )0.6(\220\027\007\024\f\022\024\023\017\004\036)]TJ 0 Tw (-)Tj T* (\f\022\017 \017\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\035\026\023\026\030\024\021\024\n\017\017.)Tj 0.006 Tc 0.278 Tw T* [(\206\030\031\023\023\026 \f\030\026\r\027\036\027\017\016 \235\024\030\n\ \017\030\024\r\026\035\026\f\034 \030\036\021\030\024\f\023\036\022\021\017\ \r\027\024)6( )]TJ 0.077 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r, \023\036\030\036\027\201\f\001\017\b\ \026\027\026\035\024\020\017\004\027\t\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \030\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.134 Tw T* (\036\022\006\017\024\027\027\t\036 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \017)Tj /Span<>> BDC ( )Tj EMC [(\031\007\024\r\035\036\021\r\024\030\016\r\001\017\b \021\036\n)6( )]TJ 0.121 Tw T* (\032\036 \022\030\017\021\036\030\017\016\n \r\022\035\033\004\036\027\017\ \016 \017)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\016. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\024\021\002\024)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.238 Tw T* (\030\036 \031\004\017\021\t\r\026\035\017\f\034 \f\024\023\024\f\021\026\ \r\017\n\024\f\021\034 \023\024)Tj /Span<>> BDC ( )Tj EMC [(\023\024\035\031, \r\024\030\026\f\021\031)6( )]TJ 0.37 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC [(\021\017\023\031 \024\023\036\030\026\006\017\017 \(\031\030\024\r\036\027\ \034 \026\027\026\f\021\024\n\024\026\). \217\026\027\017\006\026)6( )]TJ 0.232 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \n\036\032\007\031 \023\026\006\017\036\027\021\ \026\n\017 \007\r\031\b \020\030\031\023\023 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.022 Tw 0 -1.218 TD [(\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \027\036 \023\030\036\r\ \t\001\026\035\026 5 \035\036\021; \f\031\013\036\f\021\r\036\027\027\t\b\ )6( )]TJ 0.184 Tw 0 -1.218 TD (\030\026\035\017\004\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\007\035\017\021\036\035\034\027\024\f\021\017 \024\023\036\030\026\006\017\ \017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\031 \017\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.248 Tw 0 -1.218 TD [(\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 \022\030\024\ \r\024\023\024\021\036\030\017 \021\026\022\032\036 \027\036 \024\021\n\036\ \004\036\027\024)6( )]TJ 0 Tc 0 Tw 0 -1.218 TD (\()Tj /T1_2 1 Tf 0.376 0 Td (p)Tj /T1_0 1 Tf 0.006 Tc /Span<>> BDC 0.484 0 Td ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC (0,05\).)Tj 0 Tc -0.023 Tw -0.86 -1.218 Td [(\221\026\022\017\n \024\002\030\026\024\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036 )0.5(\r\022\035\033\004\036\027\026 )0.5(\r\f\016 )0.5(\007\024\f\021\031\023)]TJ 0 Tw (-)Tj 0.077 Tw 0 -1.218 TD (\027\026\016 \f\024\r\024\022\031\023\027\024\f\021\034 \023\026\006\017\ \036\027\021\024\r, \031\007\024\r\035\036\021\r\024\030\016\033\013\017\ \b \022\030\017)Tj 0 Tw (-)Tj 0.229 Tw T* (\021\036\030\017\016\n, \026)Tj /Span<>> BDC ( )Tj EMC (\031\022\026\026\027\027\t\005 \023\036\030\017\024\007, \002\036 \007\ \024\023\024\035\027\017\021\036\035\034\027\t\b )Tj 0.168 Tw 23.244 64.543 Td (\253\024\004\017\f\021\024\022\273 \024\f\027\024\r\027\024\005 \020\030\ \031\023\023\t; \030\036\021\030\024\f\023\036\022\021\017\r\027\t\005 \023\ \024\007)Tj 0 Tw (-)Tj T* (\002\024\030 \022\026\f\026\035\f\016 \021\024\035\034\022\024 \020\030\031\ \023\023\t \f\030\026\r\027\036\027\017\016.)Tj 0.205 Tw T* (\211 \r\f\036\b \023\026\006\017\036\027\021\024\r \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2263-\017 \f\031\021\022\017 \023\024\f\035\036\024\023\036\030\026\006\ \017\024\027)Tj 0 Tw (-)Tj T* (\027\024\020\024 \023\036\030\017\024\007\026 \024\006\036\027\017\r\026\ \035\017 \f\035\036\007\031\033\013\017\036 \023\024\022\026\026\021\036\ \035\017:)Tj 0.264 Tw T* (\251)Tj /Span<>> BDC [( )-3( )]TJ EMC 1 0 Td (\n\026\030\022\036\030\t \024\022\f\017\007\026\021\017\r\027\024\020\024\ \f\021\030\036\f\f\026: \n\026\035\024\027\024\r\t\005 \007\017)Tj 0 Tw (-)Tj T* (\026\035\034\007\036\020\017\007 \(\204\212\202\), \007\017\036\027\024\r\ \t\036 \022\024\027\255\033\020\026\021\t \(\212\025\);)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\026\027\021\017\024\022\f\017\007\026\027\021\027\026\016 \026\013\017\ \021\026: \026\f\022\024\030\002\017\027\024\r\026\016 \022\017\f\035\024\ \021\026;)Tj 1.203 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )936( )]TJ EMC 1 0 Td (\n\026\030\022\201\030 \007\036\020\030\026\007\026\006\017\017 \022\024\ \035\035\026\020\036\027\026: \f\r\024\002\024\007\027\t\005 )Tj 0 Tw 0 -1.218 TD (\024\022\f\017\023\030\024\035\017\027;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\035\026\022\021\026\021 \023\035\026\n\t \022\026\022 \017\027\007\017\ \022\026\021\024\030\026 \021\022\026\027\036\r\024\005 \020\017\023\024\ \022\f\017\017;)Tj -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-267( )]TJ EMC 1 0 Td (\r\027\031\021\030\017\002\030\033\001\027\024\036 \007\026\r\035\036\027\ \017\036 \(\200\207\212\).)Tj 0.116 Tw -1 -1.218 Td (\211\030\024\r\036\027\034 \204\212\202 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 \024\023\030\036\007\036\ \035\016\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\030\036)Tj 0 Tw (-)Tj 0.147 Tw 0 -1.218 TD (\026\022\006\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (2-\021\017\024\002\026\030\002\017\021\031\030\024\r\024\005 \022\017\f\035\ \024\021\024\005 \f)Tj /Span<>> BDC ( )Tj EMC (\030\036\020\017\f\021\030\026\006\017)Tj 0 Tw (-)Tj 0.364 Tw 0 -1.218 TD (\036\005 \024\023\021\017\004\036\f\022\024\005 \023\035\024\021\027\024\ \f\021\017 \f\023\036\022\021\030\024\235\024\021\024\n\036\021\030\017\004\ \036\f\022\017. )Tj 0.07 Tw 0 -1.218 TD (\212\017\036\027\024\r\t\036 \022\024\027\255\033\020\026\021\t \024\006\ \036\027\017\r\026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\005 \n\036)Tj 0 Tw (-)Tj 0.196 Tw 0 -1.218 TD (\021\024\007\017\022\036 \023\024)Tj /Span<>> BDC ( )Tj EMC (\206\026\r\030\017\035\024\r\031. \025\024\027\006\036\027\021\030\026\006\ \017\033 \026\f\022\024\030\002\017\027\024\r\024\005 )Tj 0.221 Tw 0 -1.218 TD (\022\017\f\035\024\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\t\r\024\030\024\021\022\036 \022\030\024\r\017 \024\023\030\036\007\036\ \035\016\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 )Tj 0.173 Tw 0 -1.218 TD (\221\017\035\034\n\026\027\f\026. \211\030\024\r\036\027\034 \f\r\024\002\ \024\007\027\024\020\024 \024\022\f\017\023\030\024\035\017\027\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\t)Tj 0 Tw (-)Tj 0.126 Tw 0 -1.218 TD (\r\024\030\024\021\022\036 \022\030\024\r\017 \017\f\f\035\036\007\024\r\ \026\035\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\017\022\036 \207\036\030\020\n\026\027\026\226)Tj 0.087 Tw 0 -1.218 TD (\214\024\022\f\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\007\017\235\017\022\026\006\017\017 \222.\222.)Tj /Span<>> BDC ( )Tj EMC (\221\036\021\016\027\036\031. \211\030\024\r\036\027\034 \035\026\022\021\ \026)Tj 0 Tw (-)Tj 0.152 Tw 0 -1.218 TD (\021\026 \023\035\026\n\t \024\023\030\036\007\036\035\016\035\017 \022\ \024\035\024\030\017\n\036\021\030\017\004\036\f\022\017\n \n\036\021\024\ \007\024\n )Tj 0.315 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\030\036\026\022\006\017\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\024\022\f\017\007\017\235\036\027\017\035\024\n. \200\036\ \035\017\004\017\027\031 \r\027\031)Tj 0 Tw (-)Tj 0.119 Tw 0 -1.218 TD (\021\030\017\002\030\033\001\027\024\020\024 \007\026\r\035\036\027\017\016\ \(\200\207\212, \n\n \030\021. \f\021.\) \024\006\036\027\017\r\026\035\ \017 )Tj -0.007 Tw 0 -1.218 TD (\023\024)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021\027\024\005 \n\036\021\024\007\017\022\036\ \004\036\030\036 \n\024\004\036\r\024\005 \023\031\t\030\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.043 Tw 0 -1.218 TD [(\023\024\035\034\024\r\026\027\017\036\n \020\030\026\007\031\017\030\024\ \r\026\027\027\024\005 )0.5(\f\017\f\021\036\n\t, \r)]TJ /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\017 )Tj -0.024 Tw 0 -1.218 TD (\023\026\006\017\036\027\021\026 \035\201\032\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\023\017\027\036, \027\026)Tj /Span<>> BDC ( )Tj EMC (\r\t\007\024\b\036, \004\036\030\036 5\22610 \n\017\027\031\021 )Tj -0.007 Tw 0 -1.218 TD (\023\024\f\035\036 \022\026\021\036\021\036\030\017\026\006\017\017, \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\201\n\036 \r\r\036\007\201\027\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\n\024\004\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\r\024\005 \023\031\t\030\034 \030\026\f\021\r\024\030\026 \027\036 \002\ \024\035\036\036 25 \n\035.)Tj /T1_3 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_0 1 Tf 0.053 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\024\002\030\026\002\024\021\022\026 )0.5(\007\026\027\027\t\b )0.6(\023\030\024\r\024\007\017\035\026\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.803 0 Td (\017\f)Tj 0 Tw (-)Tj 0.104 Tw -20.803 -1.218 Td [(\023\024\035\034\024\r\026\027\017\036\n \023\026\022\036\021\024\r IBM\ SPS)17(S S)15(t)15(a)15(t)-32(ist)-32(ics 22.0 \(IBM )]TJ -0.034 Tw 0 -1.218 TD [(Cor)-24(p., \222\231\202\) \017)]TJ /Span<>> BDC ( )Tj EMC [(MedCal)16(c \(MedCal)16.1(c S)-16(of)-28(t)-32(w)-12(ar)-23.9(e L)45(td., \210\f\021\036\027\007\036, )]TJ -0.057 Tw 0 -1.218 TD (\207\036\035\034\020\017\016\). \203\024\030\n\026\035\034\027\024\f\021\ \034 \030\026\f\023\030\036\007\036\035\036\027\017\016 \022\024\035\017\ \004\036\f\021\r\036\027)Tj 0 Tw (-)Tj 0.302 Tw 0 -1.218 TD (\027\t\b \007\026\027\027\t\b \023\030\024\r\036\030\016\035\017 \022\030\ \017\021\036\030\017\036\n \231\026\023\017\030\024\226\211\017\035\022\026\ . )Tj 0.104 Tw 0 -1.218 TD (\222)Tj /Span<>> BDC ( )Tj EMC (\031\004\201\021\024\n \024\021\027\024\f\017\021\036\035\034\027\024 \027\ \036\002\024\035\034\001\024\020\024 \024\002\255\201\n\026 \r\t\002\024\ \030\022\017 )Tj 0.216 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\016\r\035\036\027\027\t\b \024\021\022\035\024\027\036\027\017\005 \ \024\021 \027\024\030\n\026\035\034\027\024\020\024 \030\026\f\023\030\036\ )Tj 0 Tw (-)Tj 0.503 Tw 0 -1.218 TD [(\007\036\035\036\027\017\016 )0.6(\002\024\035\034\001\017\027\f\021\r\024 )0.5(\022\024\035\017\004\036\f\021\r\036\027\027\t\b )0.6(\023\030\017\027\026\022\024\r )]TJ 0.098 Tw 0 -1.218 TD (\024\023\017\f\t\r\026\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \n\036\007\017\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\022\r\026\030\021\017\035\034\027\024\020\024 \030\026)Tj 0 Tw (-)Tj 0.051 Tw 0 -1.218 TD (\n\026\b\026)Tj /Span<>> BDC ( )Tj EMC (\227 Me [Q1\226Q3]. \212\035\016 \f\030\026\r\027\036\027\017\016 \022\024\ \035\017\004\036\f\021\r\036\027\027\t\b )Tj 0.045 Tw 0 -1.218 TD (\023\030\017\027\026\022\024\r \n\036\032\007\031 \007\r\031\n\016 \027\ \036\026\r\017\f\017\n\t\n\017 \020\030\031\023\023\026\n\017 \017\f)Tj 0 Tw (-)Tj 0.147 Tw 0 -1.218 TD [(\023\024\035\034\024\r\026\035\017 )0.6(\027\036\023\026\030\026\n\036\021\030\017\004\036\f\022\017\005 )0.6(U-\022\030\017\021\036\030\017\005 )0.5(\204\026\027\027\026\226)]TJ 0.084 Tw 0 -1.218 TD (\211\017\021\027\017. \025\026\004\036\f\021\r\036\027\027\t\036 \023\030\ \017\027\026\022\017 \023\030\036\007\f\021\026\r\035\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 )Tj 0.325 Tw 0 -1.218 TD (\026\002\f\024\035\033\021\027\t\b \027\026\004\036\027\017\005 \()Tj /T1_2 1 Tf 0 Tw (n)Tj /T1_0 1 Tf 0.325 Tw (\) \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\036\005 \(%\); \030\026\035\017\004\017\016 )Tj 0.126 Tw 0 -1.218 TD (\n\036\032\007\031 \020\030\031\023\023\026\n\017 \024\006\036\027\017\r\ \026\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \245\262-\022\030\017\021\036\030\017\016 )Tj 0.113 Tw 0 -1.218 TD [(\215\017\030\f\024\027\026, )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.929 0 Td [(\024\032\017\007\026\036\n\t\b )0.6(\004\026\f\021\024\021\026\b)]TJ /Span<>> BDC ( )Tj EMC 8.96 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.845 0 Td [(5 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 1.665 0 Td (\250)Tj /Span<>> BDC ( )Tj EMC 0.845 0 Td [(20% )0.5(\016\004\036)]TJ 0 Tw (-)Tj -18.245 -1.218 Td (\036\022)Tj /Span<>> BDC ( )Tj EMC (\227 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \021\024\004\027\024\020\ \024 \022\030\017\021\036\030\017\016 \205\017\001\036\030\026.)Tj 0.247 Tw 0 -1.218 TD (\212\035\016 \017\031\004\036\027\017\016 \235\026\022\021\024\030\024\r\ \030\017\f\022\026 \203\202 \r\t\023\024\035\027\016\035\017 \031\027\017\ )Tj 0 Tw (-)Tj 0.393 Tw 0 -1.218 TD (\r\026\030\017\026\027\021\027\t\005 \002\017\027\026\030\027\t\005 \035\ \024\020\017\f\021\017\004\036\f\022\017\005 \030\036\020\030\036\f\f\017\ \024\027)Tj 0 Tw (-)Tj 0.251 Tw 0 -1.218 TD (\027\t\005 \026\027\026\035\017. \212\035\016 \022\026\032\007\024\020\024\ \023\030\036\007\017\022\021\024\030\026 \030\026\f\f\004\017\021\t\r\026\ )Tj 0 Tw (-)Tj 0.236 Tw 0 -1.218 TD (\035\017 \024\021\027\024\001\036\027\017\036 \001\026\027\f\024\r \(\210\ \231\) \f)Tj /Span<>> BDC ( )Tj EMC (95% \007\024\r\036\030\017\021\036\035\034\027\t\n )Tj 0.278 Tw 0 -1.218 TD (\017\027\021\036\030\r\026\035\024\n \(\212\230\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \200\026\035\034\007\026 \017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_0 1 Tf (-\027\026\004\036\027\017\036. )Tj 0.298 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC 1.076 0 Td [(\017\f\b\024\007\027\t\005 )0.6(\023\031\035 )0.5(\023\036\030\036\n\036\027\027\t\b )0.6(\007\035\016 )0.5(\n\027\024\020\024\235\026\022\021\024\030\027\024\005 )]TJ 0.764 Tw -1.076 -1.218 Td (\035\024\020\017\f\021\017\004\036\f\022\024\005 \030\036\020\030\036\f\f\ \017\017 \r\022\035\033\004\026\035\017 \023\024\022\026\026\021\036\035\ \017, )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.2026 56.0378 Tm (94)Tj ET endstream endobj 1054 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022\224\005\025\013\t\ \025)21(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-10(\026)11(\025\213\026)11(\004\020\200\t\025\016)-9.9(\026\n )]TJ 0 -1 TD [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 35.864 1 Td [(Ne)11(w appr)20(oach)11(es to\022pr)31(ediction of\022colonic\022anastomotic leakage )]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 540.8533 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 540.8533 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 513.2455 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 513.2455 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 42.5197 459.1763 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 0.007 Tw 9 0 0 9 90.7087 730.4919 Tm [(\(MD)30(A\), free h)12(y)14(dro)14(xyp)46(roline, conjug)12.1(ated dienes, ascorbic acid, lactate and sero)13(tonin, as w)12(ell as intra-abdominal p)45.9(res)]TJ 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD [(sure \(IAP\), w)12(ere measured.)]TJ 0.089 Tw T* [(RESUL)30(T)-10(S: P)18(atients with C)-18(AL had signif)-43(icantly higher median lev)13(els of MD)30(A \(4,4 [3,9\2314,7] vs 3,1 [2,4\2313,6] nmol/)]TJ 0.148 Tw T* (mL; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\), free h)12(y)14(dro)14.1(xyp)46(roline \(18,0 [15,7\23119,6] vs 12,7 [11,1\23114,8] \251mol/L; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.001\) and IAP \(16,1 )Tj -0.011 Tw T* ([14,2\23117,9] vs 10.5 [8,8\23115,1] mmHg; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\) on postoperativ)13.1(e d)25.9(ays 2\2313 as com)16(pared with controls. R)19(OC analy)]TJ 0 Tw 44.743 0 Td (-)Tj -0.001 Tw -44.743 -1.111 Td [(sis show)12(ed good discr)-36.9(iminativ)13(e ability of free h)12(y)14(dro)14.1(xyp)46(roline for C)-18(AL: A)29(UC 0.83 \(95% conf)-42.9(idence inter)-41.9(v)15.9(al \(CI\) 0.72\231)]TJ 0.043 Tw T* (0.93; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\); at a cut-of)-39.9(f)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(15 \251mol/L, sensitivity w)13(as 79.1% \(95% CI 63.9\23189.9\), specif)-42.9(icity 77.3% \(95% CI )]TJ 0.016 Tw T* [(54.6\23192.2\), positiv)13(e p)46(redictiv)13(e v)16(alue \(PPV\) 87.2% \(95% CI 72.6\23195.7\) and neg)11.9(ativ)13(e p)46(redictiv)13(e v)16(alue \(NPV\) 65.4% )]TJ 0.093 Tw T* (\(95% CI 44.3\23182.8\). IAP)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(15 mmHg yielded an A)29(UC of 0.78 \(95% CI 0.65\2310.90; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.001\), sensitivity 69.8% )Tj 0.108 Tw T* [(and specif)-42.9(icity 72.7%; MD)30(A)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (4.0 nmol/mL)Tj /Span<>> BDC ( )Tj EMC [(\227 A)28.9(UC 0.80 \(95% CI 0.68\2310.91; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.001\), sensitivity 74.4% and )Tj -0.021 Tw T* [(specif)-43(icity )0.7(77.3%. )0.6(In )0.5(multiv)16.1(ar)-37(iable )0.6(logistic )0.6(reg)14(ression, )0.6(free )0.6(h)12(y)14(dro)14(xyp)46(roline )0.6(\(odds )0.6(ratio )0.6(\(OR\) )0.5(1.35; )0.6(95% )0.6(CI )0.5(1.08\2311.69; )]TJ 0.058 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.009\), IAP \(OR 1.35; 95% CI 1.10\2311.65; p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.004\) and MD)30(A \(OR 2.86; 95% CI 1.25\2316.56; p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.013\) w)12(ere )]TJ 0.098 Tw T* [(identif)-42.9(ied as independent p)46(redictors of C)-18(AL. The combined )0.5(three-mark)17.1(er model show)12(ed high p)46(rognostic accuracy)12(: )]TJ 0.023 Tw T* [(A)29(UC 0.93 \(95% CI 0.84\2310.98; p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.001\); p \(Hos)33(mer)23.1(-Lemeshow test\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.34; N)18(ag)12(elk)17(erk)17(e R\262)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.65.)Tj 0.102 Tw 0 -1.111 TD [(C)21(ON)22(CLUSION: com)16(p)46(rehensiv)13.1(e assess)33(ment of collag)12.1(enolysis mark)17.1(ers and intra-abdominal h)12(yper)-40(tension in the early )]TJ 0.023 Tw 0 -1.111 TD [(postoperativ)13.1(e per)-37(iod allows highly accurate p)46(rediction of the r)-37(isk of anastomo)13(tic leak)11(ag)12.1(e.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 42.5596 565.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( colonic anastomosis suture failure, p)46(rognosis, o)14(xid)26(ativ)13(e stress, o)14(xyp)46(roline, intra-abdominal p)46(ressure)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.037 Tc 0.135 Tw -9.871 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_3 1 Tf 0.023 Tc 0.144 Tw 6.58 0 Td [( R)-6.5(u)-22.8(z)-35.8(i)-6(b)-20.3(o)-15(y)-33.9(z)-11.3(o)-20.4(d)-9.2(a)]TJ /Span<>> BDC ( )Tj EMC [(K)-27(.R)-21.4(.)-23.5(, G)-11.2(u)-8.3(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(M)-7.1(.K)-27(.)-23.5(, G)-11.2(u)-8.4(l)-20.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-23(.)-23.8(A)-23(.)-23.5(, N)-5.6(u)-7.6(r)-42.9(z)-11.2(o)-20.4(d)-9.3(a)]TJ /Span<>> BDC ( )Tj EMC [(Z)-22.9(.)-7.3(M)-7.1(.)-23.5(, A)-11.7(l)-16.7(i)-12.8(-)1.5(Z)-34(a)-13(d)-15.3(e)]TJ /Span<>> BDC ( )Tj EMC [(S)-9.6(.)15(G)-11.6(. N)-14.5(e)-12.5(w a)-8.8(p)-12.3(p)-13.7(r)-15.8(o)-18.2(a)-11.1(c)-10.2(h)-15.1(e)-22.8(s t)-21.9(o)]TJ /Span<>> BDC ( )Tj EMC [(p)-13.7(r)-19.1(e)-21(d)-15.8(i)-5(c)-41.5(t)-46.2(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(c)-6.5(o)-15.6(l)-20.9(o)-9.2(n)-14(i)-5(c)23( )]TJ 0.024 Tw -6.585 -1.2 Td [(a)-7.6(n)-7.8(a)-26.6(s)-29.3(t)-21.9(o)-9.2(m)-12.4(o)-15.8(t)-46.2(i)-5(c l)-23.7(e)-13(a)-11.2(k)-24.2(a)-10.8(g)-14.4(e)-6.9(. )]TJ /T1_1 1 Tf 0.033 Tc -0.033 Tw 9.62 0 Td [(K)13.9(ol)3.6(op)2.4(r)3.1(o)3.4(k)-19.2(t)2.2(ol)3.6(o)-3.3(g)-13.2(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.023 Tc 0.024 Tw 7.019 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)19.9(;)9.8(2)-1.4(5)0.9(\()37.7(1)44.3(\))14.5(:)-1.4(9)-2.8(2)9.8(\226)50.8(1)14(0)-23.4(0)6.5(. \()-0.9(i)-3.2(n R)-6.5(u)-21.9(s)-22.3(s)-15.5(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.7(s)-8(:)1.9(/)84.7(/)36.4(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.8(/)11.2(1)14(0)6.5(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.6(8/)7.9(2)-8.9(0)9.3(7)-1.9(3)-13.3(-)41.2(7)10.7(55)-8.9(6)-26.7(-)9.7(2)-8.9(0)-3.8(2)4.1(6)-26.7(-)9.8(2)-1.5(5)-23.5(-)55.2(1)26.9(-)-4.2(9)-2.9(2)12.1(-)55.2(1)14(0)-23.4(0)]TJ /T1_2 1 Tf 0.01 Tc 0.025 Tw -16.634 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc 0.03 Tw 10.591 0 Td ( \206\r\016\022\240\031\235\016\031\030\020 \202\020\200\032\020\026\031\ \025 \206\r\016\022\240\031\235, \216\217\210 \253\020\030\255\022\n\024\ \n\022\235 \b\031\024\r\030\020\032\024\023\021\027\025\025\013\235 \026\ \027\030\022\006\022\025\024\n\022\235 \r\025\022\021\027\032\024\022\023\ \027\023 \022\026\027\025\022 \003\240\r \020\f\022 )Tj 0.023 Tw -10.596 -1.2 Td (\022\240\025\022 \205\022\025\031\273, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\022\025\031, 29-31, \220\r\213\020\025\240\027, 734026, \020\030\255\ \022\n\022\024\023\020\025; e-mail: dr.hero85@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.038 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.043 Tw 14.091 0 Td [( R)22(uzibo)12(yzod)26(a K)17(ahramon R)22(uzibo)12(y)42(, A)14(vicenna T)54(a)10(jik S)28(tate Medical U)22(niv)13(ersity)42.1(, Sino st., 29-31, Dushanbe, 734026, )]TJ 0.023 Tw -14.096 -1.2 Td [(T)54(a)10(jikistan; e-mail: dr)51(.hero85@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 26.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 26.11.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 18.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 396.0239 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.02 Tc 0.437 Tw 10 0 0 10 42.5197 371.6679 Tm [(\203\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.493 0 Td [(\f\024\r\036\030\001\036\027\f\021\r\024\r\026\027\017\036 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b)20( )]TJ 0.202 Tw -6.493 -1.218 Td (\021\036\b\027\017\022, \027\036\f\024\f\021\024\016\021\036\035\034\027\ \024\f\021\034 \026\027\026\f\021\024\n\024\026 \(\203\202\) \024\f\021\ \026)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.559 Tw 0 -1.218 TD (\036\021\f\016 \024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC [(\027\026\017\002\024\035\036\036 \026\022\021\031\026\035\034\027\t\b \023\ \030\024\002\035\036\n)20( )]TJ 0.479 Tw T* (\026\002\007\024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\ \017\017. \232\026\f\021\024\021\026 \007\026\027\027\024\020\024 \024\f\ )Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.14 Tw T* (\035\024\032\027\036\027\017\016 \r\026\030\034\017\030\031\036\021 \024\ \021 3% \007\024)Tj /Span<>> BDC ( )Tj EMC (15%, \026)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017 \027\017\022\017\b)20( )]TJ 0.027 Tw T* [(\022\024\035\024\030\036\022\021\026\035\034\027\t\b \026\027\026\f\021\024\ \n\024\026\b \n\024\032\036\021 \007\024\f\021\017\020\026\021\034 20%)20( )]TJ 0.25 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\036\036 [1,2]. \203\202 \026\f\f\024\006\017\017\030\024\r\026\ \027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\t\f\024\022\024\005 \035\036)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.047 Tw T* (\021\026\035\034\027\024\f\021\034\033 \(\007\024 16\22622%\), \027\036\024\ \002\b\024\007\017\n\024\f\021\034\033 \023\024\r\021\024\030)Tj 0 Tc 0 Tw (-)Tj 0.02 Tc 0.24 Tw T* (\027\t\b \r\n\036\001\026\021\036\035\034\f\021\r \017)Tj /Span<>> BDC ( )Tj EMC [(\235\024\030\n\017\030\024\r\026\027\017\036\n \023\024\f\021\024\016\027\ \027\024\005)20( )]TJ 0.201 Tw T* [(\f\021\024\n\t, )0.6(\004\021\024 )0.5(\f\031\013\036\f\021\r\036\027\027\024 )0.5(\f\027\017\032\026\036\021 )0.5(\022\026\004\036\f\021\r\024 )0.5(\032\017\027\017)20( )]TJ 0 Tw T* (\023\026\006\017\036\027\021\024\r)Tj /Span<>> BDC ( )Tj EMC ([3].)Tj 0 Tc 0.055 Tw T* (\200 \023\024\f\035\036\007\027\017\036 \020\024\007\t \027\026\004\017\ \021\036\035\034\027\024\036 \r\027\017\n\026\027\017\036 \031\007\036\035\ \016\036\021\f\016 )Tj 0.321 Tw T* (\030\026\027\027\017\n \035\026\002\024\030\026\021\024\030\027\t\n \023\ \030\036\007\017\022\021\024\030\026\n \203\202. \203\026\017\002\024\035\ \036\036 )Tj -0.045 Tw T* (\017\031\004\036\027\t \222-\030\036\026\022\021\017\r\027\t\005 \002\036\ \035\024\022 \(\222\217\207\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\022\026\035\034\006\017\021\024\027\017\027 )Tj 0.034 Tw T* (\(\215\025\221\), \007\035\016 \022\024\021\024\030\t\b \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\026\026\027\026\035\017\026\b \023\024\022\026\026\027\026 \ \007\017\026\020\027\024)Tj 0 Tw (-)Tj 0.194 Tw T* (\f\021\017\004\036\f\022\026\016 \006\036\027\027\024\f\021\034 \027\026\ )Tj /Span<>> BDC ( )Tj EMC (3\2265-\036 \f\031\021\022\017 \023\024\f\035\036 \022\024\035\024\030\036\ \022)Tj 0 Tw (-)Tj 0.137 Tw T* [(\021\026\035\034\027\t\b \030\036\036\022\006\017\005 \(A)17(UC 0,80\2260,84; \004\031\r\f\021\r\017\021\036\035\034\027\024\f\021\034\ )]TJ 0.391 Tw T* (70\226100%, \f\023\036\006\017\235\017\004\027\024\f\021\034 80\22690% \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b )Tj 0.048 Tw T* (\023\024\030\024\020\026\b\) [4,5]. \221\036\n \027\036 \n\036\027\036\036\ , \220\021\017 \n\026\030\022\201\030\t \024\021\030\026\032\026\033\021\ , )Tj 0.123 Tw T* [(\023\030\036\017\n\031\013\036\f\021\r\036\027\027\024, )0.6(\f\017\f\021\036\n\027\t\005 )0.6(\r\024\f\023\026\035\017\021\036\035\034\027\t\005 )0.5(\024\021\r\036\021 )]TJ 0.133 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\036 \007\026\033\021 \017\027\235\024\030\n\026\006\017\017 \024)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\034\027\t\b \n\036\b\026\027\017\n\026\b)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.469 Tw T* (\024\022\f\017\007\026\021\017\r\027\024\n \f\021\030\036\f\f\036, \007\036\ \020\030\026\007\026\006\017\017 \022\024\035\035\026\020\036\027\024\r\024\ \020\024 )Tj 0.18 Tw T* (\n\026\021\030\017\022\f\026, \021\022\026\027\036\r\024\005 \020\017\023\ \024\022\f\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\027\024\005 \020\017)Tj 0 Tw (-)Tj 0.29 Tw T* (\023\036\030\021\036\027\017\017, \017\020\030\026\033\013\017\b \022\035\ \033\004\036\r\031\033 \030\024\035\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\004\027\024\f\021\017 )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\026.)Tj 0.199 Tw 23.244 32.881 Td (\215\036\030\f\023\036\022\021\017\r\027\t\n \027\026\023\030\026\r\035\036\ \027\017\036\n \016\r\035\016\036\021\f\016 \023\024\017\f\022 \n\026\030\ )Tj 0 Tw (-)Tj 0.004 Tw T* [(\022\036\030\024\r, \024\021\030\026\032\026\033\013\017\b \023\026\021\024\ \020\036\027\036\021\017\004\036\f\022\017\036 )0.5(\n\036\b\026\027\017\n\t \027\036)]TJ 0 Tw (-)Tj 0.114 Tw T* (\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017: \035\024\022\026\ \035\034\027\031\033 \017\001\036\n\017\033, \024\022\f\017\007\026\021\017\ \r\027\t\005 )Tj 0.342 Tw T* (\f\021\030\036\f\f \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\036 \n\036\021\026\002\024\035\017\n\026\ \f\024\036\007\017\027\017\021\036\035\034\027\024\005 )Tj 0.131 Tw T* (\021\022\026\027\017 \(\022\024\035\035\026\020\036\027\024\035\017\) [\ 6]. \025\030\024\n\036 \021\024\020\024, \r\026\032\027\031\033 \030\024\ \035\034 )Tj 0.148 Tw T* (\017\020\030\026\036\021 \f\017\027\007\030\024\n \r\027\031\021\030\017\ \002\030\033\001\027\024\005 \020\017\023\036\030\021\036\027\017\017 \(\ \200\207\206\), )Tj 0.016 Tw T* (\022\024\021\024\030\t\005 \027\026\023\030\016\n\031\033 \031\b\031\007\ \001\026\036\021 \n\017\022\030\024\006\017\030\022\031\035\016\006\017\033\ \r)Tj /Span<>> BDC ( )Tj EMC (\022\017)Tj 0 Tw (-)Tj T* (\001\036\004\027\024\005 \f\021\036\027\022\036 [7].)Tj 0.617 Tw T* (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\t\036 \017\f\f\035\ \036\007\024\r\026\027\017\016 \007\036\n\024\027\f\021\030\017\030\031\033\ \021 )Tj 0.455 Tw T* [(\022\035\033\004\036\r\031\033 )0.6(\030\024\035\034 )0.5(\f\r\024\002\024\007\027\024-\030\026\007\017\022\026\035\034\027\t\b )0.6(\023\030\024\006\036\f\f\024\r )]TJ 0.101 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\001\036\027\017\016 \022\024\035\035\026\020\036\027\024\ \r\024\020\024 \n\026\021\030\017\022\f\026 \r)Tj /Span<>> BDC ( )Tj EMC (\026\032\017\r\035\036\027\017\017 )Tj 0.07 Tw T* [(\022\024\035\024\030\036\022\021\026\035\034\027\t\b )0.5(\026\027\026\f\021\024\n\024\024\r: \r\035\017\016\027\017\036 \020\017\ \023\024\022\f\017\017, )0.5(\020\017)]TJ 0 Tw (-)Tj 0.105 Tw T* [(\023\036\030\002\026\030\017\004\036\f\022\024\005 )0.6(\024\022\f\017\020\036\027\026\006\017\017, )0.5(\026\027\021\017\024\022\f\017\007\026\027\021\027\024\005 )0.6(\021\036\030\026)]TJ 0 Tw (-)Tj 0.133 Tw T* [(\023\017\017 \(\r\017\021\026\n\017\027 )0.5(C, N-\026\006\036\021\017\035\006\017\f\021\036\017\027, )0.5(\022\024\220\027\017\n )0.5(Q10\) \f\024)]TJ 0 Tw (-)Tj 0.022 Tw T* (\023\030\024\r\024\032\007\026\036\021\f\016 \017\n\036\027\036\027\017\ \036\n \031\030\024\r\027\036\005 \204\212\202, \f\r\024\002\024\007\027\ \024\020\024 )Tj 0 Tw T* (\024\022\f\017\023\030\024\035\017\027\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\004\027\024\f\021\017 \001\r\024\r [8].)Tj 0.197 Tw T* (\200 \220\021\024\005 \f\r\016\017 \023\030\036\007\f\021\026\r\035\016\ \036\021\f\016 \023\036\030\f\023\036\022\021\017\r\027\t\n \023\024\017\ \f\022 )Tj 0.416 Tw T* (\022\024\n\023\035\036\022\f\027\t\b \023\030\024\020\027\024\f\021\017\004\ \036\f\022\017\b \017\027\007\017\022\026\021\024\030\024\r, \024\021\030\ \026)Tj 0 Tw (-)Tj 0.185 Tw T* (\032\026\033\013\017\b \027\036 \021\024\035\034\022\024 \r\024\f\023\026\ \035\017\021\036\035\034\027\t\005 \024\021\r\036\021, \027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\035\024)Tj 0 Tw (-)Tj 0.127 Tw T* (\022\026\035\034\027\t\036 \023\030\024\006\036\f\f\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\036\027\022\036 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \024\022\f\017\007\026\021\017\r\027\024\036 )Tj 0.444 Tw T* [(\023\024\r\030\036\032\007\036\027\017\036, )0.6(\022\024\035\035\026\020\036\027\024\035\017, )0.6(\027\026\030\031\001\036\027\017\016 )0.5(\n\024\021\024\030\017\022\017 )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\027\024\005 \020\036\n\024\007\017\ \027\026\n\017\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 115.9299 Tm [(\017\034\r\237)5( \031\032\032\r\034\230\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.747 Tw 10 0 0 10 274.9606 91.5739 Tm [(\210\006\036\027\017\021\034 )0.5(\023\030\024\020\027\024\f\021\017\004\036\f\022\031\033 )0.6(\006\036\027\027\024\f\021\034 )0.6(\002\017\024\b\017\n\017\004\036)]TJ 0 Tw (-)Tj 0.286 Tw T* (\f\022\017\b \n\026\030\022\036\030\024\r \024\022\f\017\007\026\021\017\ \r\027\024\020\024 \f\021\030\036\f\f\026, \007\036\020\030\026\007\026\006\ \017\017 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (93)Tj ET endstream endobj 1051 0 obj [1057 0 R] endobj 1052 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 292.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 292.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 255.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 255.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-92-100)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.023 Tw 19 0 0 19 79.1962 695.3259 Tm [(\007\025\b\217\004 \224\025\202\220\025\202\217 \r\022)-23.3(\224\005\025\013\t\025)21.1(\212\n\005\025\b\017\t\n\206 \t\004\016\025\016)-9.9(\026)11(\025\213\026)11(\004\020\200\t\025\016)-10(\026\n )]TJ 5.352 -1.105 Td [(\026)11(\025\020\016)-10(\026)11(\025\r\n\204\004\225\t\025\013)10.1(\025 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\017)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 649.822 Tm [(\033)-21(\002)31(\212\n\255\025\221\212\025\202\017\022)-23.2(\037.\033)124(., \031)70(\002\020\025\b\022)-23.3(\235.\037., \031)70(\002\020\025\b\022)-23.3(\f)-31(.\f)-31(., \007\002\005)31(\212\025\202\017\022)-23.3(\203.\235., \f)-20.9(\020\n-\203\017\202\004\022)-23.3(\001.\031)72(.)]TJ 10 0 0 10 70.8661 632.1527 Tm [(\031)41(\036)20(\227 \253\032)40(\017\202\226\n\r\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-10(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026 \n\024\004\t\n \f\255\002 \017\020\n \n\255\t\n \001\n\t\025\273\ \(\002\020.\022)-23.2(\001\n\t\025, )]TJ 0 -1.2 TD [(\202.\022)-23.3(2)47(9-3)138(1)69(, \013)62(.\022)-23.2(\201\002\204\017\t\255\004, 7)57(3)58(402)46(6, \032)40(\017\202\226\n\r\n\016)-9.9(\026)11(\017\t\))]TJ /T1_0 1 Tf 0.278 Tw 9 0 0 9 119.0551 601.6488 Tm [(\037\036\035\034: )0.5(\031\006\027\025\022\023\017 )0.6(\033\032\031\b\025\031\024\023\022\007\027\024\n\r\005 )0.5(\016\025\020\007\022\026\031\024\023\017 )0.6(\026\020\032\n\027\032\031\021 )0.5(\031\n\024\022\030\020\023\022\021\025\031\b\031 )0.5(\024\023\032\027\024\024\020, )0.5(\030\027\b\032\020\030\020\006\022\022 )0.5(\n\031\f\f\020\b\027\025\020 )]TJ 0.023 Tw 0 -1.111 TD (\022)Tj /Span<>> BDC ( )Tj EMC (\021\025\r\023\032\022\240\032\005\213\025\031\235 \b\022\033\027\032\023\ \027\025\016\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\022 \025\027\024\031\024\023\031\t\023\027\f\ \017\025\031\024\023\022 \023\031\f\024\023\031\n\022\213\027\007\025\031\ \b\031 \020\025\020\024\023\031\026\031\016\020 \(\001\003\).)Tj 0.002 Tc 0.139 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \033\032\031\021\027\030\027\025\031 \032\027\023\ \032\031\024\033\027\n\023\022\021\025\031\027 \022\024\024\f\027\030\031\ \021\020\025\022\027 \033\031)Tj /Span<>> BDC ( )Tj EMC (\023\022\033\r \253\024\f\r\007\020\235-\n\031\025\023\032\031\f\017\273\ . \211)Tj /Span<>> BDC ( )Tj EMC [(\020\025\020\f\022\016)2( )]TJ 0.154 Tw T* (\021\n\f\005\007\027\025\031 65 \033\020\006\022\027\025\023\031\021 \033\ \031\024\f\027 \032\027\016\027\n\006\022\022 \023\031\f\024\023\031\235\ \n\022\213\n\022: \031\024\025\031\021\025\020\t \b\032\r\033\033\020 \(\ n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (43\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\020\006\022\027\025\023\013 \024)Tj /Span<>> BDC ( )Tj EMC (\032\020\016)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.094 Tw T* (\021\022\021\213\027\235\024\t \001\003, \b\032\r\033\033\020 \024\032\020\ \021\025\027\025\022\t \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (22\))Tj /Span<>> BDC ( )Tj EMC (\227 \033\020\006\022\027\025\023\013 \024)Tj /Span<>> BDC ( )Tj EMC (\025\027\031\024\f\031\255\025\027\025\025\013\026 \023\027\007\027\025\022\ \027\026. \001\020)Tj /Span<>> BDC ( )Tj EMC [(2\2313-\022 \024\r\023\n\022 \033\031\024\f\027)2( )]TJ 0.079 Tw 0 -1.111 TD [(\031\033\027\032\020\006\022\022 \031\006\027\025\022\021\020\f\022 \r\032\ \031\021\025\022 \026\020\f\031\025\031\021\031\b\031 \030\022\020\f\017\ \030\027\b\022\030\020 \(\215\220\003\), \024\021\031\240\031\030\025\031\ \b\031 \031\n\024\022\033\032\031\f\022\025\020, \f\020\n\023\020\023\020\ , \030\022\027\025\031\021\013\200)2( )]TJ 0.054 Tw 0 -1.111 TD (\n\031\025\236\005\b\020\023\031\021, \020\024\n\031\032\240\022\025\031\ \021\031\235 \n\022\024\f\031\023\013, \f\020\n\023\020\023\020, \024\027\ \032\031\023\031\025\022\025\020, \020)Tj /Span<>> BDC ( )Tj EMC [(\023\020\n\255\027 \021\027\f\022\007\022\025\r \021\025\r\023\032\022\240\ \032\005\213\025\031\b\031 \030\020\021\f\027\025\022\t)2( )]TJ -0.002 Tw T* (\(\211\221\220\).)Tj 0 Tc 0.237 Tw T* (\206\036\207\210\035\034\003\201: \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\001\003 \026\027\030\022\020\025\025\013\027 \r\032\031\021\025\022 \215\ \220\003 \(4,4 [3,9\2314,7] \033\032\031\023\022\021 3,1 [2,4\2313,6] \025\ \026\031\f\017/\026\f; )Tj 0.091 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC 0.801 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.823 0 Td [(0,001\), )0.6(\024\021\031\240\031\030\025\031\b\031 )0.6(\031\n\024\022\033\032\031\f\022\025\020 )0.7(\(18,0 )0.5([15,7\23119,6] )0.6(\033\032\031\023\022\021 )0.6(12,7 )0.5([11,1\23114,8] )0.6(\026\n\026\031\f\017/\f; )0.6(p)]TJ /Span<>> BDC ( )Tj EMC 37.164 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.823 0 Td [(0,001\) )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 3.777 0 Td (\211\221\220 )Tj 0.069 Tw -43.389 -1.111 Td (\(16,1 [14,2\23117,9] \033\032\031\023\022\021 10,5 [8,8\23115,1] \026\026\ \032\023. \024\023.; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\) \025\020)Tj /Span<>> BDC ( )Tj EMC (2\2313-\022 \024\r\023\n\022 \033\031\024\f\027 \031\033\027\032\020\006\ \022\022 \240\013\f\022 \024\023\020)Tj 0 Tw (-)Tj 0.053 Tw 0 -1.111 TD (\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\026\031 \021\ \013\213\027, \007\027\026 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \240\027\016 \025\027\024\031\024\023\031\t\023\027\ \f\017\025\031\024\023\022 \020\025\020\024\023\031\026\031\016\020. \004\ \032\022)Tj /Span<>> BDC ( )Tj EMC (ROC-\020\025\020\f\022\016\027 \024\021\031\240\031\030\025\013\235 )Tj 0.16 Tw 0 -1.111 TD [(\031\n\024\022\033\032\031\f\022\025 )0.5(\030\027\026\031\025\024\023\032\022\032\031\021\020\f )0.5(\200\031\032\031\213\r\005 )0.5(\030\022\024\n\032\022\026\022\025\022\032\r\005\212\r\005 )0.5(\024\033\031\024\031\240\025\031\024\023\017 \021)]TJ /Span<>> BDC ( )Tj EMC (\031\023\025\031\213\027\025\022\022 \001\003: AUC 0,83 \(95% )Tj 0.029 Tw T* [(\030\031\021\027\032\022\023\027\f\017\025\013\235 )0.6(\022\025\023\027\032\021\020\f )0.5(\(\220\002\) )0.5(0,72\2310,93; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 18.706 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.762 0 Td [(0,001\); )0.5(\033\032\022)]TJ /Span<>> BDC ( )Tj EMC 4.927 0 Td [(\033\031\032\031\b\031\021\031\026 )0.5(\016\025\020\007\027\025\022\022)]TJ /Span<>> BDC ( )Tj EMC 8.64 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC 0.762 0 Td [(15 )0.5(\026\n\026\031\f\017/\f )0.5(\007\r\021\024\023\021\022\023\027\f\017)]TJ 0 Tw (-)Tj 0.164 Tw -33.796 -1.111 Td [(\025\031\024\023\017 )0.5(\024\031\024\023\020\021\022\f\020 )0.6(79,1%, )0.6(\024\033\027\006\022\203\022\007\025\031\024\023\017)]TJ /Span<>> BDC ( )Tj EMC 17.665 0 Td [(\227 )0.5(77,3%, )0.5(\033\031\f\031\255\022\023\027\f\017\025\020\t )0.6(\033\032\031\b\025\031\024\023\022\007\027\024\n\020\t )0.5(\006\027\025\025\031\024\023\017 )0.5(\(\004\004\037\))]TJ /Span<>> BDC ( )Tj EMC 26.375 0 Td (\227 )Tj -0.003 Tw -44.039 -1.111 Td (87,2%, \031\023\032\022\006\020\023\027\f\017\025\020\t \033\032\031\b\025\ \031\024\023\022\007\027\024\n\020\t \006\027\025\025\031\024\023\017 \(\ \217\004\037\))Tj /Span<>> BDC ( )Tj EMC (\227 65,4%. \211\221\220)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (15 \026\026 \032\023. \024\023. \200\020\032\020\n\023\027\032\022\016\031\ \021\020\f\031\024\017 )Tj 0.122 Tw T* [(AUC )0.5(0,78 )0.5(\(95% )0.5(\220\002 )0.5(0,65\2310,90; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 13.475 0 Td (<)Tj /Span<>> BDC ( )Tj EMC 0.855 0 Td [(0,001\), )0.5(\007\r\021\024\023\021\022\023\027\f\017\025\031\024\023\017\005 )0.6(69,8% )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 15.913 0 Td [(\024\033\027\006\022\203\022\007\025\031\024\023\017\005 )0.5(72,7%; )0.5(\215\220\003)]TJ /Span<>> BDC ( )Tj EMC 12.738 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC 0.855 0 Td (4,0 )Tj 0.186 Tw -43.835 -1.111 Td (\025\026\031\f\017/\026\f)Tj /Span<>> BDC ( )Tj EMC (\227 AUC 0,80 \(95% \220\002 0,68\2310,91; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\), \007\r\021\024\023\021\022\023\027\f\017\025\031\024\023\017 74\ ,4%, \024\033\027\006\022\203\022\007\025\031\024\023\017 77,3%. )Tj 0.083 Tw T* (\211)Tj /Span<>> BDC ( )Tj EMC (\026\025\031\b\031\203\020\n\023\031\032\025\031\235 \f\031\b\022\024\023\ \022\007\027\024\n\031\235 \026\031\030\027\f\022 \025\027\016\020\021\022\ \024\022\026\013\026\022 \033\032\027\030\022\n\023\031\032\020\026\022 \ \001\003 \031\n\020\016\020\f\022\024\017 \024\021\031\240\031\030\025\013\ \235 \031\n\024\022\033\032\031)Tj 0 Tw (-)Tj -0.027 Tw T* [(\f\022\025 )0.5(\(\031\023\025\031\213\027\025\022\027 )0.5(\213\020\025\024\031\021 )0.5(\(\217\237\) )0.5(1,35; 95% )0.5(\220\002 1,08\2311,69; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 24.154 0 Td [(0,009\), )0.5(\211\221\220 \(\217\237 )0.5(1,35; 95% \220\002 )0.5(1,10\2311,65; p)]TJ /Span<>> BDC ( )Tj EMC 17.548 0 Td (=)Tj /Span<>> BDC ( )Tj EMC (0,004\) )Tj 0.036 Tw -41.703 -1.111 Td (\022)Tj /Span<>> BDC ( )Tj EMC 0.767 0 Td [(\215\220\003 )0.6(\(\217\237 )0.5(2,86; )0.6(95% )0.5(\220\002 )0.6(1,25\2316,56; )0.5(p)]TJ /Span<>> BDC ( )Tj EMC 15.074 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.768 0 Td [(0,013\). )0.6(\002\025\023\027\b\032\020\f\017\025\020\t )0.6(\026\031\030\027\f\017, )0.5(\031\240\236\027\030\022\025\t\005\212\020\t )0.5(\023\032\022 )0.6(\033\031\n\020\016\020\023\027\f\t, )0.5(\033\032\031)]TJ 0 Tw (-)Tj 0.101 Tw -16.61 -1.111 Td (\030\027\026\031\025\024\023\032\022\032\031\021\020\f\020 \021\013\024\031\ \n\r\005 \033\032\031\b\025\031\024\023\022\007\027\024\n\r\005 \023\031\ \007\025\031\024\023\017: AUC 0,93 \(95% \220\002 0,84\2310,98; p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,001\); \032)Tj /Span<>> BDC ( )Tj EMC (\(\023\027\024\023 )Tj 0.023 Tw T* (\225\031\024\026\027\032\020\231\035\027\026\027\213\031\r\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,34; \033\024\027\021\030\031-R\262 \001\020\235\030\255\027\f\n\027\032\ \n\020)Tj /Span<>> BDC ( )Tj EMC (\227 0,65.)Tj 0.197 Tw T* [(\207\003\202\035\224\232\036\001\002\036: )0.6(\n\031\026\033\f\027\n\024\025\020\t )0.6(\031\006\027\025\n\020 )0.5(\026\020\032\n\027\032\031\021 )0.6(\n\031\f\f\020\b\027\025\031\f\022\016\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 27 0 Td [(\021\025\r\023\032\022\240\032\005\213\025\031\235 )0.5(\b\022\033\027\032\023\027\025\016\022\022 )0.5(\(\024\021\031\240\031\030\025\013\235 )]TJ -0.017 Tw -27 -1.111 Td [(\031\n\024\022\033\032\031\f\022\025, )0.5(\215\220\003 \022)]TJ /Span<>> BDC ( )Tj EMC 7.895 0 Td [(\211\221\220\), )0.5(\021\013\033\031\f\025\027\025\025\020\t )0.5(\025\020)]TJ /Span<>> BDC ( )Tj EMC [(2\2313-\022 )0.5(\024\r\023\n\022 \033\031\024\f\027 )0.5(\031\033\027\032\020\006\022\022, \033\031\016\021\031\f\t\027\023 \024)]TJ /Span<>> BDC ( )Tj EMC 26.699 0 Td [(\021\013\024\031\n\031\235 )0.5(\023\031\007\025\031\024\023\017\005 \033\032\031)]TJ 0 Tw (-)Tj 0.033 Tw -34.593 -1.111 Td (\b\025\031\016\022\032\031\021\020\023\017 \032\022\024\n \001\003 \022)Tj /Span<>> BDC ( )Tj EMC (\021\013\030\027\f\t\023\017 \033\020\006\022\027\025\023\031\021 \b\032\ \r\033\033\013 \021\013\024\031\n\031\b\031 \032\022\024\n\020 \030\f\t \ \240\031\f\027\027 \022\025\023\027\025\024\022\021\025\031\b\031 \026\031\ \025\022\023\031\032\022\025\b\020 )Tj 0.023 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\032\020\025\025\027\235 \n\031\032\032\027\n\006\022\022 \023\027\032\020\ \033\022\022.)Tj /T1_2 1 Tf 0.01 Tc 0.009 Tw 8 0 0 8 70.9061 326.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_0 1 Tf 0 Tc 0.014 Tw 8.484 0 Td ( \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\017 \023\031\ \f\024\023\031\n\022\213\027\007\025\031\b\031 \020\025\020\024\023\031\026\ \031\016\020, \033\032\031\b\025\031\016\022\032\031\021\020\025\022\027\ , \031\n\024\022\030\020\023\022\021\025\013\235 \024\023\032\027\024\024\ , \031\n\024\022\033\032\031\f\022\025, \021\025\r\023\032\022)Tj 0 Tw (-)Tj 0.023 Tw -8.489 -1.2 Td (\240\032\005\213\025\031\027 \030\020\021\f\027\025\022\027)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.028 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.018 Tc -0.035 Tw 9.048 0 Td ( \217\031\017\002\024\005\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\025.\217., \206\031\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\025., \206\031\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \203\031\030\024\007\026)Tj /Span<>> BDC ( )Tj EMC (\003.\204., \202\035\017-\003\026\007\036)Tj /Span<>> BDC ( )Tj EMC (\222.\206. \203\024\r\t\036 \023\024\007\b\024\007\t \022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\020\027\024\017\030\024\r\026\027\017\033 \027\036\f\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc -0.035 Tw -9.053 -1.2 Td (\f\021\024\016\021\036\035\034\027\024\f\021\017 \021\024\035\f\021\024\022\ \017\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026. )Tj /T1_0 1 Tf -0.008 Tw (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf -0.035 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC (1, \f.)Tj /Span<>> BDC ( )Tj EMC (92\226100. https://doi.org/10.33878/2073-7556-2026-)Tj 0.023 Tc -0.023 Tw 0 -1.2 TD (25-1-92-100)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0 Tc 0.023 Tw 18 0 0 18 188.6772 229.0332 Tm [(Ne)11(w appr)20(oach)11(es to\022)-23.3(pr)31(ediction )]TJ 0 Tw ( )Tj 0.023 Tw -0.151 -1.167 Td [(of\022)-23.3(colonic\022)-23.2(anastomotic leakage)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 70.8661 183.5292 Tm [(K)41(ahr)21(amon\022)-23.3(R.\022)-23.2(Ru)21(ziboy)21(z)10(oda, Mahmadsh)11(oh\022)-23.2(K.\022)-23.3(Gulov)21(, Afz)15.1(alsh)11(o\022)-23.3(A)-31(.\022)-23.3(Gulov)21.1(, )]TJ 0 -1.143 TD [(Z)21(oir)20(sh)11(o\022)-23.2(M.\022)-23.3(Nur)20(z)10(oda, Sukhr)20.1(ob\022)-23.3(G.\022)-23.3(Ali-Z)21.1(ade)]TJ 10 0 0 10 70.8661 149.86 Tm [(A)20(vicenna T)40(ajik State Medical Univ)12.1(er)20(sit)-20(y \(Sino\022)-23.2(st., 2)47(9-3)138(1)69(, Dushanbe, 7)57(3)58(402)46(6, T)40(ajikistan\))]TJ /T1_0 1 Tf 0.029 Tw 9 0 0 9 119.0551 131.356 Tm [(\003IM: to assess the p)46(rognostic signif)-43(icance of mark)17(ers of o)14(xid)26(ativ)13(e stress, collag)12(en deg)14(rad)26(ation and intra-abdominal )]TJ 0.023 Tw 0 -1.111 TD [(h)12(yper)-40(tension in the dev)13(elopment of colorectal anastomo)13.1(tic leak)11.1(ag)12(e.)]TJ -0.029 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: retrospectiv)13.1(e case-control study w)13(as conducted including 65 patients af)-45.9(ter colorectal resec)]TJ 0 Tw (-)Tj 0.053 Tw T* [(tion: the study g)14(roup \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(43\) com)16(p)46(r)-36.9(ised patients who dev)13(eloped anastomo)13.1(tic leak)11(ag)12(e, and the com)16(par)-37(ison g)14(roup )]TJ -0.03 Tw T* (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(22\) included patients with an unev)13(entful postoperativ)13.1(e course. The g)14(roups w)12(ere com)16(parable in ter)-14(ms of ag)12(e, se)-15(x, )]TJ -0.024 Tw 0 -1.111 TD [(operativ)13(e time and intraoperativ)13.1(e blood loss \(p)]TJ /Span<>> BDC ( )Tj EMC (>)Tj /Span<>> BDC ( )Tj EMC [(0.05\). On postoperativ)13.1(e d)26(ays 2\2313, serum lev)13(els of malondialdeh)12(y)14(de )]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 610.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 76.0071 601.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 70.8661 139.8604 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 73.5728 130.9331 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_1 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.115 56.0378 Tm (92)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 396.85 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 397.481 736.808 m 397.242 736.808 397.049 736.616 397.049 736.376 c 397.049 736.376 l 397.049 726.285 l 397.049 726.045 397.242 725.853 397.481 725.853 c 397.481 725.853 l 455.382 725.853 l 455.62 725.853 455.815 726.045 455.815 726.285 c 455.815 726.285 l 455.815 736.376 l 455.815 736.616 455.62 736.808 455.382 736.808 c 455.382 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 426.4320445 736.8086309 cm BX /Sh0 sh EX Q Q q 396.85 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 413.5634 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 414.6923 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 418.0385 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 422.1581 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 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\200\035\026\007\ \017\n\017\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.307 Tw 0 -1.218 TD (\024\027\022\024\035\024\020 \024\021\007\036\035\036\027\017\016 \026\002\ \007\024\n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\017\ \017 \2232, )Tj 0.14 Tw T* (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; ORCID )Tj 0 Tw T* (0000-0003-2429-0834)Tj 0.739 Tw T* (\231\017\030\026\035\017\036\r \217\031\f\035\026\027 \204\026\020\024\n\ \036\021-\202\n\017\027\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.307 Tw T* (\024\027\022\024\035\024\020 \024\021\007\036\035\036\027\017\016 \026\002\ \007\024\n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\017\ \017 \2232, )Tj 0.14 Tw T* (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; ORCID )Tj 0 Tw T* (0000-0002-7346-4610)Tj 0.155 Tw 23.244 24.356 Td (\216\026\035\026\235\016\027 \202\035\036\022\f\026\027 \202\035\034\002\ \036\030\021\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\021.\027., \007\024\006\036\027\021 \022\026)Tj 0 Tw (-)Tj 0.154 Tw T* [(\235\036\007\030\t )0.5(\026\027\026\035\017\026 )0.6(\007\026\027\027\t\b )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.17 0 Td [(\017\f\022\031\f\f\021\r\036\027\027\024\020\024 )0.6(\017\027\021\036\035\035\036\022)]TJ 0 Tw (-)Tj 0.324 Tw -11.17 -1.218 Td (\021\026 \205\215\204, \025\031\002\026\027\f\022\017\005 \020\024\f\031\ \007\026\030\f\021\r\036\027\027\t\005 \031\027\017\r\036\030\f\017\021\036\ \021; )Tj 0 Tw T* (ORCID 0000-0003-2324-3649 SPIN-\022\024\007: 3917\2266210)Tj 0.24 Tw T* (\025\026\031\001\026\027\f\022\017\005 \200\026\035\036\030\017\005 \207\ \024\030\017\f\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\r\036\007\031)Tj 0 Tw (-)Tj 0.398 Tw T* (\033\013\017\005 \024\021\007\036\035\036\027\017\036\n \026\002\007\024\ \n\017\027\026\035\034\027\024\005 \024\027\022\024\035\024\020\017\017 \ \2232, )Tj 0.423 Tw 0 -1.218 TD (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; \007\024)Tj 0 Tw (-)Tj 0.268 Tw 0 -1.218 TD (\006\036\027\021 \022\026\235\036\007\030\t \b\017\030\031\030\020\017\004\ \036\f\022\017\b \002\024\035\036\027\036\005, \025\031\002\026\027\f\022\ \017\005 )Tj 0.291 Tw T* (\020\024\f\031\007\026\030\f\021\r\036\027\027\t\005 \n\036\007\017\006\017\ \027\f\022\017\005 \031\027\017\r\036\030\f\017\021\036\021; ORCID )Tj 0 Tw T* (0000-0001-7839-6410)Tj 0.426 Tw T* (\213\030\n\026\022\024\r \213\r\020\036\027\017\005 \202\035\036\022\f\036\ \036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \026\n\036\f\021\017)Tj 0 Tw (-)Tj 0.509 Tw T* (\021\036\035\034 \020\035\026\r\027\024\020\024 \r\030\026\004\026 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017,\ )Tj 0.14 Tw 0 -1.218 TD (\025\035\017\027\017\004\036\f\022\017\005 \024\027\022\024\035\024\020\017\ \004\036\f\022\017\005 \007\017\f\023\026\027\f\036\030 \2231; ORCID )Tj 0 Tw 0 -1.218 TD (0009-0003-7280-2360; SPIN-\022\024\007: 7388-9323)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(V)25(adim V. P)10.1(ol)30(ov)-16(ink)-16(in)]TJ /Span<>> BDC ( )Tj EMC (\227)Tj 5.83 0 0 5.83 395.1256 533.3118 Tm ( )Tj 10 0 0 10 396.4839 529.9818 Tm (0000-0003-3649-1027)Tj -9.318 -1.218 Td [(Nikol)-16(a)15.1(y V. Dor)-32(onin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2429-0834)Tj T* [(Rusl)-15.9(an M-A. S)-16(hir)-32.9(al)-31(iyev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-7346-4610)Tj T* [(Ale)-17.9(x)-11(an A. Khal)-15.9(af)-34(y)22(an)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2324-3649)Tj T* [(V)25(aler)-37(iy B. K)-15.9(aushansk)-15.9(iy)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7839-6410)Tj T* [(Ev)-21(geniy A. Er)-15.8(makov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0003-7280-2360)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 432.5579 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.174 Tw 8 0 0 8 70.8661 419.7232 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Miles)Tj /Span<>> BDC ( )Tj EMC 2.467 0 Td [(WE. )0.6(A)]TJ /Span<>> BDC ( )Tj EMC 2.85 0 Td [(me)-12(t)-13(hod )0.6(of)]TJ /Span<>> BDC ( )Tj EMC 4.712 0 Td [(per)-24(for)-15.9(ming )0.5(abd)-16(omino-per)-36.9(ineal )0.6(e)-18(x)-13(c)-24(ision )]TJ -0.008 Tw -11.325 -1.25 Td [(for car)-31.9(c)-24(inoma of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he r)-24(ec)-16(tum and of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ter)-16(minal por)-22(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he pel)30(v)-16(ic )]TJ 0.098 Tw 0 -1.25 TD [(col)30(on \(1908\). )]TJ /T1_1 1 Tf [(C)-18(A Cancer J Clin)]TJ /T1_0 1 Tf [(. 1971;21\(6\):361\226364. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.3322/)Tj T* [(canjcl)-31(in.21.6.361)]TJ 0 0 0 1 k /GS1 gs 0.203 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Holm)Tj /Span<>> BDC ( )Tj EMC (T, Ljung)Tj /Span<>> BDC ( )Tj EMC [(A, H\344ggmar)-23.9(k)]TJ /Span<>> BDC ( )Tj EMC [(T, Jur)-24(ell)]TJ /Span<>> BDC ( )Tj EMC [(G, L)-32(a)-17(ger)-31.9(gr)-24(en)]TJ /Span<>> BDC ( )Tj EMC [(J. E)35(xtended )]TJ 0.103 Tw -1.296 -1.25 Td [(abd)-16(ominoper)-36.9(ineal r)-23.9(esec)-16(t)-32(ion )0.5(wi)-24(t)-13(h )0.5(gl)35(uteus )0.5(maximus )0.5(fl)-16(ap )0.5(r)-24(econstr)-21.9(uc)]TJ 0 Tw (-)Tj 0.033 Tw T* [(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he pel)30(v)-15.9(ic fl)30.1(o)-16(or for r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_1 1 Tf (Br J Surg)Tj /T1_0 1 Tf (. 2007;94\(2\):232\226)Tj 0.023 Tw T* [(238. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.5489)Tj 0 0 0 1 k /GS1 gs 0.117 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Zhou)Tj /Span<>> BDC ( )Tj EMC (X, Sun)Tj /Span<>> BDC ( )Tj EMC (T, Xie)Tj /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)15(t)17(or abd)-16(ominoper)-37(ineal e)-17.9(x)-13(c)-24(i)]TJ 0 Tw (-)Tj 0.184 Tw -1.296 -1.25 Td [(sion for )0.5(l)30(o)-14(w r)-23.9(ec)-16(t)15(al cancer: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew and )0.5(me)-12(t)15(a-anal)35(y)-13(sis )]TJ 0.321 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he shor)-22(t-ter)-15.9(m outcome. )]TJ /T1_1 1 Tf (Colorectal Dis.)Tj /T1_0 1 Tf ( 2015;17\(6\):474\226481. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.12921)Tj 0 0 0 1 k /GS1 gs 0.057 Tw -1.847 -1.25 Td (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Muster)-9.9(s)]TJ /Span<>> BDC ( )Tj EMC [(GD, Kl)-15.9(aver)]TJ /Span<>> BDC ( )Tj EMC [(CEL, Bosk)10(er)]TJ /Span<>> BDC ( )Tj EMC [(RJI, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Biol)30.1(o)-16(gical Mesh Cl)30(osur)-23.9(e )]TJ 0.179 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he P)30(el)30.1(v)-16(ic Fl)30(o)-16(or Af)-28(ter )0.5(E)35(xtr)-33(alev)-15(a)15(t)17.1(or A)-14(bd)-16(ominoper)-37(ineal )0.5(R)13(esec)-16(t)-32(ion )]TJ 0.181 Tw T* [(for R)13(ec)-16(t)15(al Cancer: A)]TJ /Span<>> BDC ( )Tj EMC [(Mul)56.1(t)-32(icenter R)-10(and)-16(omized Contr)-32(olled T)50(r)-37(ial \(t)-13(he )]TJ 0 Tw T* [(BIOPEX-stud)17.1(y\). )]TJ /T1_1 1 Tf 0.241 Tw 6.63 0 Td (Ann Surg)Tj /T1_0 1 Tf [(. 2017;265\(6\):1074\2261081. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -6.63 -1.25 Td [(SL)-35(A.0000000000002020)]TJ 0 0 0 1 k /GS1 gs 0.289 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Bl)30(ok)]TJ /Span<>> BDC ( )Tj EMC (RD, de Jonge)Tj /Span<>> BDC ( )Tj EMC [(J, de K)25(oning)]TJ /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. P)35(r)-32(opensi)-23.9(t)-10(y S)-24(cor)-24(e )]TJ 0.172 Tw -1.296 -1.25 Td [(A)15(d)17(justed Com)10(p)32(ar)-36.9(ison of)]TJ /Span<>> BDC ( )Tj EMC [(P)30(el)30(v)-15.9(iper)-37(ineal M)-24(or)-23.9(bidi)-24(t)-10(y W)-16(i)-24(t)-12.9(h and W)-16(i)-24(t)-12.9(hout )]TJ 0.301 Tw T* [(Oment)17(opl)-16(ast)-9.9(y F)10(oll)30.1(o)-14(wing A)-13.9(bd)-16(ominoper)-37(ineal R)13(esec)-16(t)-32(ion for P)35(r)-37(imar)-23.9(y )]TJ 0.002 Tw T* [(R)13(ec)-16(t)15(al Cancer. )]TJ /T1_1 1 Tf [(Dis Colon R)21(ectum.)]TJ /T1_0 1 Tf [( 2019;62\(8\):952\226959. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj T* (DCR.0000000000001349)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.356 Tw T* [(6)0.5(.)]TJ /Span<>> BDC 0.815 0 Td ( )Tj EMC 0.51 0 Td [(A)-24.5(g)0.5(g)0.5(a)0.5(r)-37.6(w)-11.5(a)0.5(l)]TJ /Span<>> BDC 3.835 0 Td ( )Tj EMC [(N)0.5(,)0.5( S)0.5(e)0.5(sh)0.5(a)0.5(d)0.5(r)-36.5(i)]TJ /Span<>> BDC 5.499 0 Td ( )Tj EMC [(R)0.5(A)0.5(,)0.5( A)0.5(r)-31.5(v)-15.5(i)0.5(nd)]TJ /Span<>> BDC 5.208 0 Td ( )Tj EMC [(A)0.5(,)0.5( e)-11.5(t)]TJ /Span<>> BDC 2.806 0 Td ( )Tj EMC [(a)0.5(l)0.5(.)0.5( P)30.5(e)0.5(r)-36.5(i)0.5(ne)0.5(a)0.5(l)0.5( W)20.5(o)0.5(u)0.5(nd)10( )]TJ 0 Tc 0.32 Tw -18.673 -1.25 Td [(Com)10(pl)-31(ica)15(t)-31.9(ions F)10(oll)30.1(o)-14(wing E)35(xtr)-32.9(alev)-15(a)15(t)17(or )0.5(A)-14(bd)-16(ominoper)-36.9(ineal )0.5(E)35(x)-13(c)-24(ision: )]TJ 0.008 Tc 0.35 Tw T* [(E)34.9(xper)-37(ience )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 6.475 0 Td (a)Tj /Span<>> BDC ( )Tj EMC 1.062 0 Td [(R)13(egional )0.5(Cancer )0.5(Center. )]TJ /T1_1 1 Tf 10.992 0 Td [(Indian )0.5(J Surg Oncol.)]TJ /T1_0 1 Tf 0 Tc 0 Tw 9.109 0 Td ( )Tj 0.023 Tw -27.638 -1.25 Td [(2018;9\(2\):211\226214. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s13193-018-0741-y)Tj 0 0 0 1 k /GS1 gs 0.002 Tc 0.349 Tw T* [(7)0.5(.)]TJ /Span<>> BDC ( )Tj EMC 1.301 0 Td [(W)22.5(es)0.5(t)]TJ /Span<>> BDC 1.896 0 Td ( )Tj EMC [(N)0.5(P)0.5(, A)0.5(n)0.5(de)0.5(r)-36.5(i)0.5(n)]TJ /Span<>> BDC ( )Tj EMC [(C)0.5(,)0.5( Sm)0.5(i)-23.5(t)-12.5(h)]TJ /Span<>> BDC 9.86 0 Td ( )Tj EMC [(K)20.5(J,)0.5( e)-11.5(t)]TJ /Span<>> BDC 3.141 0 Td ( )Tj EMC [(a)0.5(l)0.5(. E)0.5(u)0.5(r)-31.6(o)0.5(p)0.5(e)0.5(an)0.5( E)35.5(xt)0.5(r)-32.5(a)0.5(l)0.5(ev)-14.5(a)15.5(t)17.4(o)0.5(r)2( )]TJ 0 Tc 0.35 Tw -16.197 -1.25 Td [(A)-14.1(bd)-16.1(ominoper)-37.1(ineal )0.5(E)34.9(x)-13.1(c)-24.1(ision S)14.9(tud)16.9(y )0.5(G)19.9(r)-32.1(oup. )0.5(Mul)55.9(t)-32.1(icentr)-24(e e)-18(xper)-37.1(ience )]TJ 0.126 Tw T* [(wi)-24(t)-13(h e)-18(xtr)-32.9(alev)-15(a)15(t)17(or abd)-16(ominoper)-36.9(ineal e)-18(x)-13(c)-24(ision for l)30.1(o)-14(w r)-24(ec)-16(t)15.1(al cancer. )]TJ /T1_1 1 Tf 0.023 Tw T* (Br J Surg)Tj /T1_0 1 Tf [(. 2010;97\(4\):588\226599. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.6916)Tj 0 0 0 1 k /GS1 gs -0.015 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(De Nar)-24(di)]TJ /Span<>> BDC ( )Tj EMC (P, Summo)Tj /Span<>> BDC ( )Tj EMC [(V, V)-15(ignal)-31(i)]TJ /Span<>> BDC ( )Tj EMC [(A, Cap)25(r)-24(e)-12(t)-30(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(G. S)15(t)15(and)42(ar)-24(d ver)-10(sus e)-18(xtr)-32.9(al)]TJ 0 Tw (-)Tj 0.002 Tw -1.296 -1.25 Td [(ev)-15(a)15(t)17(or abd)-16(ominoper)-36.9(ineal l)30(o)-14(w r)-23.9(ec)-16(t)15(al cancer e)-18(x)-12.9(c)-24(ision outcomes: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(s)]TJ 0 Tw (-)Tj -0.027 Tw T* [(tema)15(t)-32(ic r)-23.9(ev)-16(iew and me)-12(t)15(a-anal)35(y)-12.9(sis. )]TJ /T1_1 1 Tf (Ann Surg Oncol)Tj /T1_0 1 Tf (. 2015;22\(9\):2997\226)Tj 0.023 Tw T* [(3006. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1245/s10434-015-4368-8)Tj 0 0 0 1 k /GS1 gs 0.02 Tc 0.708 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.355 0 Td [(\204\031)0.5(\030\026\001\022)0.5(\024)]TJ /Span<>> BDC ( )Tj EMC [(\217)0.5(.\202.)0.5(, \211)0.5(\r\026\030\024)0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\230)0.5(.\207.)0.5(, \213)0.5(\030\n\026\022)0.5(\024\r)]TJ /Span<>> BDC ( )Tj EMC [(\213.\202)0.5(., \017)]TJ /Span<>> BDC ( )Tj EMC [(\f\024\026\r)0.5(\021.)20( )]TJ 0 Tc 0.35 Tw 27.7 42.5 Td (\233\022\f\021\030\026\035\036\r\026\021\024\030\027\026\016 \002\030\033\ \001\027\024-\023\030\024\n\036\032\027\024\f\021\027\026\016 \220\022\f\ \021\017\030\023\026\006\017\016 \023\030\016\n\024\005 )Tj -0.043 Tw T* (\022\017\001\022\017: \027\036\023\024\f\030\036\007\f\021\r\036\027\027\ \t\036 \030\036\031\035\034\021\026\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\021\030\026\007\017\006\017\024\027\027\024\005 )Tj 0 Tw T* (\021\036\b\027\017\022\024\005. )Tj /T1_1 1 Tf 4.325 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t)Tj /T1_0 1 Tf -0.003 Tw [(. 2017;\(4\):34\22639. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj -4.325 -1.25 Td (7556-2017-0-4-34-39)Tj 0 0 0 1 k /GS1 gs 0.198 Tw [( / Mur)-32.9(ashko)]TJ /Span<>> BDC ( )Tj EMC [(R.A., Uv)-15(ar)-31.9(ov)]TJ /Span<>> BDC ( )Tj EMC [(I.B., Er)-16(makov)]TJ /Span<>> BDC ( )Tj EMC (E.A., )Tj 0.04 Tw T* [(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)15(t)17(or A)-14(bd)-16(ominoper)-36.9(ineal E)35(x)-13(c)-24(ision of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he R)13(ec)-16(tum: S)-16(hor)-22(t-)]TJ 0.255 Tw T* [(T)40(er)-16(m Outcomes in Com)10(p)32(ar)-37(ison wi)-23.9(t)-13(h t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(Convent)-31.9(ional T)40(echnique. )]TJ /T1_1 1 Tf 0 Tw T* [(K)18(olop)46(roktologia)]TJ /T1_0 1 Tf 0.239 Tw [(. 2017;\(4\):34\22639. \(in Russ.\). )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.33878/2073-)Tj T* (7556-2017-0-4-34-39)Tj 0 0 0 1 k /GS1 gs 0.024 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (He)Tj /Span<>> BDC ( )Tj EMC [(Z, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(XY, Y)50(ang)]TJ /Span<>> BDC ( )Tj EMC [(X)16(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he cl)-30.9(inical ef)-56(f)-28(ica)-17(cy )]TJ 0.014 Tw -1.796 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.062 0 Td [(l)-16(ap)32(ar)-32(oscopic )0.5(e)-18(xtr)-32.9(alev)-15(a)15(t)17(or )0.5(abd)-16(ominoper)-36.9(ineal )0.5(e)-18(x)-13(c)-24(ision )0.5(\(EL)-34.9(APE\) )0.5(and )]TJ -0.005 Tw -1.062 -1.25 Td [(non-EL)-34.9(APE for l)30(o)-14(w r)-24(ec)-15.9(t)15(al cancer. )]TJ /T1_1 1 Tf [(U)21(pd)26(ates Surg.)]TJ /T1_0 1 Tf ( 2023;75\(3\):611\226617. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s13304-023-01466-y)Tj 0 0 0 1 k /GS1 gs 0.207 Tw -1.847 -1.25 Td (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Y)35(u)]TJ /Span<>> BDC ( )Tj EMC [(HC, P)30(eng)]TJ /Span<>> BDC ( )Tj EMC (H, He)Tj /Span<>> BDC ( )Tj EMC [(X)-19.9(S, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Com)10(p)32(ar)-37(ison of)]TJ /Span<>> BDC ( )Tj EMC [(shor)-21.9(t- and l)30(ong-)]TJ 0.252 Tw -1.796 -1.25 Td [(ter)-16(m outcomes af)-28(ter e)-18(xtr)-32.9(alev)-15(a)15(t)17(or abd)-16(ominoper)-36.9(ineal e)-18(x)-12.9(c)-24(ision and )]TJ 0.099 Tw T* [(st)15(and)42(ar)-24(d abd)-16(ominoper)-36.9(ineal e)-18(x)-13(c)-23.9(ision for r)-24(ec)-16(t)15(al cancer: a)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic )]TJ 0.058 Tw T* [(r)-24(ev)-15.9(iew and me)-12(t)15(a-anal)35(y)-13(sis)]TJ /T1_1 1 Tf (. Int J Colorectal Dis.)Tj /T1_0 1 Tf ( 2014;29\(2\):183\226191. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-013-1793-7)Tj 0 0 0 1 k /GS1 gs 0.078 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Qi)Tj /Span<>> BDC ( )Tj EMC (XY, Cui)Tj /Span<>> BDC ( )Tj EMC [(M, L)-32(iu)]TJ /Span<>> BDC ( )Tj EMC [(MX, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)15(t)17(or abd)-16(ominoper)-37(ineal e)-17.9(x)-13(c)-24(i)]TJ 0 Tw (-)Tj 0.009 Tw -1.796 -1.25 Td [(sion ver)-9.9(sus abd)-16(ominoper)-36.9(ineal e)-18(x)-12.9(c)-24(ision for )0.5(l)30(o)-14(w r)-23.9(ec)-16(t)15(al cancer: )0.5(a)]TJ /Span<>> BDC ( )Tj EMC [(me)-12(t)15(a-)]TJ 0 Tw T* [(anal)35(y)-13(sis. )]TJ /T1_1 1 Tf -0.008 Tw 3.705 0 Td [(Chin Med J \(Eng)13.1(l\).)]TJ /T1_0 1 Tf [( 2019;132\(20\):2446\2262456. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -3.705 -1.25 Td (CM9.0000000000000485)Tj 0 0 0 1 k /GS1 gs 0.195 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Habr-Gama)Tj /Span<>> BDC ( )Tj EMC [(A, S\343o Jul)-30.9(i\343o)]TJ /Span<>> BDC ( )Tj EMC [(GP, Ma)15(t)-29.9(t)15(a)-17(cheo)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. E)35(xtr)-33(alev)-14.9(a)14.9(t)17.1(or )]TJ 0.267 Tw -1.796 -1.25 Td [(A)-14(bd)-16(ominal )0.5(P)30(er)-36.9(ineal )0.5(E)35(x)-13(c)-24(ision )0.5(V)30(er)-10(sus )0.5(S)15(t)15(and)42(ar)-24(d )0.5(A)-14(bd)-16(ominal )0.5(P)30(er)-36.9(ineal )]TJ 0.012 Tc 0.442 Tw T* [(E)35(x)-12.9(c)-24(ision: Im)10(p)32(a)-17(c)-15.9(t on Q)-16(ual)-30.9(i)-24(t)-9.9(y of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he R)13(esec)-16(ted Spec)-24(imen and)12( )]TJ 0.009 Tc 0.352 Tw T* [(P)9.6(ost)16.6(oper)-33.4(a)14.6(t)-32.3(i)-16.4(ve M)-24.4(or)-24.3(bidi)-24.4(t)-10.4(y. )]TJ /T1_1 1 Tf [(W)28.6(orld J Surg.)]TJ /T1_0 1 Tf [( 2017;41\(8\):2160\2262167.)9( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00268-017-3963-1)Tj 0 0 0 1 k /GS1 gs -0.004 Tw -1.847 -1.25 Td (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(R)-10(ad)-17(w)-12(an)]TJ /Span<>> BDC ( )Tj EMC [(RW, T)40(ang)]TJ /Span<>> BDC ( )Tj EMC [(AM, Har)-24(r)-36.9(ies)]TJ /Span<>> BDC ( )Tj EMC [(RL, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)30(er)-22(t)-32(ical r)-23.9(ec)-16(tus abd)-16(ominis )]TJ 0.231 Tw -1.796 -1.25 Td [(fl)-16(ap )0.6(\(VRAM\) )0.6(for )0.5(per)-37(ineal )0.6(r)-24(econstr)-21.9(uc)-16(t)-32(ion )0.6(foll)30(o)-14(wing )0.6(pel)30(v)-16(ic )0.6(sur)-32(ger)-24(y: )]TJ 0.041 Tw T* (A)Tj /Span<>> BDC ( )Tj EMC 0.828 0 Td [(sy)-13(stema)15.1(t)-32(ic )0.5(r)-24(ev)-16(iew. )]TJ /T1_1 1 Tf 7.809 0 Td [(J )0.5(Plast )0.5(R)21(econstr )0.5(Aesthet )0.6(Surg.)]TJ /T1_0 1 Tf [( )0.5(2021;74\(3\):523\226)]TJ 0.023 Tw -8.636 -1.25 Td [(529. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.bjps.2020.10.100)Tj 0 0 0 1 k /GS1 gs 0.013 Tw T* (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(K)-16(asai)]TJ /Span<>> BDC ( )Tj EMC [(S, K)-15.9(a)-17(ga)10(w)-12(a)]TJ /Span<>> BDC ( )Tj EMC [(H, S)-16(hiomi)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Inc)-24(idence and r)-37(isk f)16(a)-17(c)-16(t)17(or)-10(s for )]TJ 0.089 Tw -1.796 -1.25 Td [(per)-37(ineal her)-14.9(nia af)-28(ter r)-32(obo)17(t)-32(ic abd)-16(ominoper)-36.9(ineal r)-23.9(esec)-16(t)-32(ion: a)]TJ /Span<>> BDC ( )Tj EMC (single-)Tj 0.078 Tw T* [(center, r)-23.9(e)-12(tr)-32(ospec)-16(t)-32(i)-15.9(ve cohor)-22(t stud)17.1(y. )]TJ /T1_1 1 Tf [(T)54(ech Colop)46(roctol. )]TJ /T1_0 1 Tf 0 Tw (2024;28\(1\):79. )Tj 0.023 Tw T* [(P)20(ubl)-31(ished 2024 Jul 4. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-024-02961-z)Tj 0 0 0 1 k /GS1 gs 0.011 Tc 0.401 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.839 0 Td (\206\035\026\007\t\001\036\r)Tj /Span<>> BDC ( )Tj EMC (\212.\200., \204\024\017\f\036\036\r)Tj /Span<>> BDC ( )Tj EMC (\204.\213., \231\036\035\036\020\036\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\222., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 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\005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf -0.017 Tw 10 0 0 10 42.5197 493.4479 Tm (\007\030\036\027\017\030\024\r\026\027\017\016, \004\026\f\021\024\021\026\ \031\f\023\036\001\027\t\b \017\f\b\024\007\024\r \f\024\f\021\026\r\035\ \016\035\026 )Tj 0 Tw 0 -1.218 TD (\035\017\001\034 30%.)Tj 0.16 Tw T* (\200 \027\026\001\036\n \017\f\f\035\036\007\024\r\026\027\017\017, \b\024\ \021\016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\036 \030\026\027\027\017\b \024\f)Tj 0 Tw (-)Tj 0.132 Tw T* (\035\024\032\027\036\027\017\005 \030\026\027\017\006\026 \027\036 \007\ \024\f\021\017\020\035\026 \f\021\026\021\017\f\021\017\004\036\f\022\024\ \005 \027\026)Tj 0 Tw (-)Tj 0.146 Tw T* [(\004\017\n\024\f\021\017, )0.5(\027\026\002\035\033\007\026\036\021\f\016 )0.6(\021\036\027\007\036\027\006\017\016 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 15.227 0 Td [(\036\036 )0.5(\031\n\036\027\034\001\036\027\017\033. )]TJ -15.227 -1.218 Td (\200\026\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\024\r\024\005 \023\035\026\f\021\017\022\017\ \030\036\032\036 )Tj -0.015 Tw T* [(\r\f\021\030\036\004\026\035\017\f\034 )0.5(\f\036\030\024\n\026 \017)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\020\027\024\036\027\017\036, )0.5(\004\021\024 )0.5(\r\036\030\024\016\021\027\024 \f\r\016\026)]TJ 0 Tw (-)Tj 0.014 Tw T* (\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\220\235\235\036\022\021\017\r\027\t\n \026\023\024\035\027\036\027\017\ \036\n \023\024\035\024\f\021\017 \021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\031\035\031\004)Tj 0 Tw (-)Tj 0.508 Tw T* (\001\036\027\017\036\n \007\030\036\027\017\030\024\r\026\027\017\016. \215\ \024\016\r\035\036\027\017\036 \027\036\022\030\024\026 \022\030\026\016\ )Tj 0.171 Tw T* (\035\024\f\022\031\021\026 \r)Tj /Span<>> BDC ( )Tj EMC (4% \f\035\031\004\026\036\r \023\024\007\004\201\030\022\017\r\026\036\021\ \027\036\024\002\b\024\007\017\n\024\f\021\034 )Tj 0.299 Tw T* (\021\013\026\021\036\035\034\027\024\005 \024\006\036\027\022\017 \r\026\ \f\022\031\035\016\030\017\026\006\017\017 \n\024\002\017\035\017\031\036\ \n\t\b )Tj 0 Tw T* (\021\022\026\027\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\030\026\002\024\021\022\017 \021\036\b\027\017\022\017 \r\t\007\ \036\035\036\027\017\016 \035\024\f\022\031\021\026.)Tj 0.129 Tw T* (\215\030\017 \026\027\026\035\017\036 \024\021\007\026\035\201\027\027\t\ \b \030\036\031\035\034\021\026\021\024\r \024\021\n\036\004\036\027\026\ \021\036\027)Tj 0 Tw (-)Tj 0.296 Tw T* (\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t \023\024\007\027\ \017\b \024\f\035\024\032\027\036\027\017\005 )Tj 0.219 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \027\024\r\024\005 \023\035\026\f\021\017\022\017\ , \r\022\035\033\004\026\016 \023\030\024\n\036\032\027\024\f\021\027\031\ \033 )Tj -0.025 Tw T* (\020\030\t\032\031 \(2%, 8% \017)Tj /Span<>> BDC ( )Tj EMC (6%, \n\036\007\017\026\027\026 \007\035\017\021\036\035\034\027\024\f\021\ \017 \027\026\002\035\033\007\036)Tj 0 Tw (-)Tj 0.086 Tw T* (\027\017\016 14 \n\036\f\016\006\036\r\). \233\021\024 \f\r\016\026\027\ \024 \f)Tj /Span<>> BDC ( )Tj EMC (\f\024\007\026\027\017\036\n \023\030\024\004\027\024\020\024 )Tj 0.037 Tw T* (\n\t\001\036\004\027\024-\235\026\f\006\017\026\035\034\027\024\020\024 \ \f\035\024\016, \031\022\030\036\023\035\016\033\013\036\020\024 \021\026\ \024\r\024\036 )Tj -0.009 Tw T* (\007\027\024, \021\024\020\007\026 \022\026\022 \023\030\024\f\021\024\036\ \031\001\017\r\026\027\017\036 \017\035\017 \031\f\021\026\027\024\r\022\ \026 \f\036\021\022\017 )Tj 0.037 Tw T* (\027\036 \r\f\036\020\007\026 \024\002\036\f\023\036\004\017\r\026\033\021\ \007\024\035\020\024\r\030\036\n\036\027\027\031\033 \023\024\007\007\036\ \030\032\022\031 )Tj 0.077 Tw T* ([26,27]. \222\024\020\035\026\f\027\024 \030\036\031\035\034\021\026\021\ \026\n \n\027\024\020\017\b \017\f\f\035\036\007\024\r\026\027\017\005, \ )Tj 0.125 Tw T* (\004\026\f\021\024\021\026 \030\026\r\017\021\017\016 \023\030\024\n\036\ \032\027\024\f\021\027\024\005 \020\030\t\032\017 \023\024\f\035\036 \023\ \030\017)Tj 0 Tw (-)Tj 0.088 Tw T* [(\n\036\027\036\027\017\016 )0.6(\030\026\035\017\004\027\t\b )0.5(\f\023\024\f\024\002\024\r )0.5(\023\035\026\f\021\017\022\017 )0.6(\023\024\f\035\036 )0.5(\233\035\207\215\233 )]TJ 0.095 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \022\024\035\036\002\035\036\ \021\f\016 \024\021 3,3% \007\024)Tj /Span<>> BDC ( )Tj EMC (67% [3,14,15]. )Tj 0.118 Tw T* (\203\036\024\002\b\024\007\017\n\024 \024\021\n\036\021\017\021\034, \004\ \021\024 \023\030\036\007\035\024\032\036\027\027\t\005 \027\026\n\017 \f\ \023\024)Tj 0 Tw (-)Tj 0.02 Tw T* (\f\024\002 \023\035\026\f\021\017\022\017 \016\r\035\016\036\021\f\016 \030\ \026\027\024\r\017\007\027\024\f\021\034\033 \027\036\f\r\024\002\024\007\ \027\024\005 )Tj 0.36 Tw T* (\026\031\021\024\023\035\026\f\021\017\022\017 \022\024\032\027\024-\n\t\ \001\036\004\027\t\n\017 \035\024\f\022\031\021\026\n\017, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj -0.003 Tw T* (\023\024\035\034\024\r\026\027\017\036 \017\n\036\027\027\024 \220\021\017\ \b \n\036\021\024\007\017\022 \023\024\r\024\035\016\036\021 \f\027\017\ \017\021\034 )Tj 0.151 Tw T* (\030\017\f\022\017 \235\024\030\n\017\030\024\r\026\027\017\016 \023\030\ \024\n\036\032\027\024\f\021\027\024\005 \020\030\t\032\017 [2,28]. )Tj -0.026 Tw T* (\233\235\235\036\022\021\017\r\027\024\f\021\034 \007\026\027\027\024\005\ \021\036\b\027\017\022\017 \026\022\030\t\021\017\016 \030\026\027\t \r\ )Tj /Span<>> BDC ( )Tj EMC (\023\035\026)Tj 0 Tw (-)Tj 0.036 Tw T* [(\027\036 )0.5(\004\026\f\021\024\021\t \030\026\r\017\021\017\016 )0.5(\023\030\024\n\036\032\027\024\f\021\027\024\005 )0.6(\020\030\t\032\017 )0.5(\f\024\023\024\f\021\026)]TJ 0 Tw (-)Tj T* (\r\017\n\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\036\n \f\036\021\004\026\021\t\b \017\ \n\023\035\026\027\021\024\r [29,30].)Tj 0.308 Tw T* (\211\035\031\004\001\036\027\017\036 \022\026\004\036\f\021\r\036\027\027\ \t\b \023\024\022\026\026\021\036\035\036\005 \032\017\027\017, \024\f\ \024)Tj 0 Tw (-)Tj 0.004 Tw T* (\002\036\027\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\026\f\023\036\022\021\036 \002\024\035\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\036\020\024 \r\024\f\023\030\017\016\021\017\016 \007\024\030\ \024\r\034\016, )Tj 0.126 Tw T* (\016\r\035\016\036\021\f\016 \022\035\033\004\036\r\t\n \026\030\020\031\ \n\036\027\021\024\n \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\034\031 \r\027\036\007\030\036\027\017\016 )Tj -0.037 Tw 23.244 41.405 Td (\007\026\027\027\024\005 \n\036\021\024\007\017\022\017. \230\n\036\027\027\ \024 \220\021\017 \023\026\030\026\n\036\021\030\t \024\023\030\036\007\036\ \035\016\033\021 )Tj 0.081 Tw T* (\031\f\023\036\b \030\036\026\002\017\035\017\021\026\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\r\030\026\013\036\027\017\036 \023\026\006\017\036\027\021\026 \022\ )Tj /Span<>> BDC ( )Tj EMC (\023\024\035)Tj 0 Tw (-)Tj -0.022 Tw T* (\027\024\006\036\027\027\024\005 \032\017\027\017 \023\024\f\035\036 \021\ \026\022\024\005 \021\016\032\036\035\024\005 \024\023\036\030\026\006\017\ \017 [31].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 432.5579 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.634 Tw 10 0 0 10 274.9606 408.2019 Tm [(\215\030\036\007\035\024\032\036\027\027\t\005 )0.6(\f\023\024\f\024\002 )0.5(\023\035\026\f\021\017\022\017 )0.6(\023\030\024\n\036\032\027\024\f\021\027\024\005 )]TJ 0.033 Tw T* (\030\026\027\t \023\024\f\035\036 \233\035\207\215\233 \023\030\016\n\024\ \005 \022\017\001\022\017, \024\f\027\024\r\026\027\027\t\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tw (-)Tj 0.164 Tw T* (\023\024\035\034\024\r\026\027\017\017 \007\036\220\023\017\021\036\035\ \017\017\030\024\r\026\027\027\024\020\024 \022\024\032\027\024-\023\024\ \007\022\024\032)Tj 0 Tw (-)Tj 0.57 Tw T* [(\027\024-\235\026\f\006\017\026\035\034\027\024\020\024 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 9.337 0 Td [(\023\036\030\036\n\036\013\036\027\027\024\020\024 )0.6(\021\030\036\031\020\024\035\034\027\024\020\024 )]TJ 0.303 Tw -9.337 -1.218 Td (\035\024\f\022\031\021\024\r, \023\030\036\007\f\021\026\r\035\016\036\021\ \f\024\002\024\005 \220\235\235\036\022\021\017\r\027\t\005 \n\036\021\024\ \007 )Tj 0.215 Tw T* (\030\036\022\024\027\f\021\030\031\022\006\017\017. \213\020\024 \023\030\ \017\n\036\027\036\027\017\036 \023\024\r\024\035\016\036\021 \f\027\017\ \017\021\034 )Tj 0.307 Tw T* (\017\027\021\036\027\f\017\r\027\024\f\021\034 \023\024\f\035\036\024\023\ \036\030\026\006\017\024\027\027\024\005 \002\024\035\017, \031\035\031\004\ \001\017\021\034 )Tj 0.309 Tw T* [(\022\026\004\036\f\021\r\024 )0.5(\032\017\027\017 )0.6(\023\026\006\017\036\027\021\024\r )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 13.246 0 Td [(\024\021\007\026\035\036\027\027\024\n )0.6(\023\036\030\017\024\007\036 )]TJ 0.017 Tw -13.246 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\n\024\027\f\021\030\017\030\031\036\021 \021\036\027\007\036\027\ \006\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t \022\026\022 )Tj 0.034 Tw T* (\030\026\027\027\017\b, \021\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\027\017\b \024\f\035\024\032\027\036\027\017\005, \r)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\027\024\f\021\017, \023\030\024)Tj 0 Tw (-)Tj T* (\n\036\032\027\024\f\021\027\t\b \020\030\t\032.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.026 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.024 Tc 0.05 Tw [( \004)-15.2(\031)-13.8(\f)-20.7(\031)-14.4(\021)-18.5(\022)-16.8(\025)-13.3(\n)-11.3(\022)-16.8(\025)]TJ /Span<>> BDC 20.061 0 Td ( )Tj EMC [(\211.)4.5(\211.)-16.2(,)-24( )]TJ -0.005 Tc 0.005 Tw -20.061 -1.218 Td [(\220)3.4(\031\032)-4.9(\031\025)5.1(\022)2.2(\025)]TJ /Span<>> BDC 3.495 0 Td ( )Tj EMC [(\001)23.8(.)23.5(\211)19.3(.)]TJ /T1_1 1 Tf 0 Tc 0.554 Tw -3.495 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 )0.5(\n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035\026)3.7(:)]TJ /T1_4 1 Tf -0.024 Tc 0.578 Tw [( )0.5(\004)-15.2(\031)-13.9(\f)-20.7(\031)-14.4(\021)-18.5(\022)-16.8(\025)-13.2(\n)-11.4(\022)-16.7(\025)]TJ /Span<>> BDC 19.533 0 Td ( )Tj EMC 0.787 0 Td [(\211.)4.5(\211.)-16.2(,)-24( )]TJ 0 Tc 0.426 Tw -20.319 -1.218 Td [(\220)8.4(\031)4.9(\032\031)5.3(\025)10.1(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.8(.)28.5(\211)24.3(.)7.8(, \237)14.1(\022)4.8(\032)3(\020)-5.2(\f)9.6(\022)3.8(\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\206)93.9(.)20.1(\215)19.4(.)47.3(-)-0.9(\003)-2.3(.)7.8(, \202)16.1(\020)-3.3(\r)9.3(\213)6.2(\020)4.4(\025)3.2(\024)4.1(\n)12.7(\022)10.1(\235 \211)24.3(.)27.5(\221)-4.4(, )]TJ -0.01 Tc 0.01 Tw T* [(\036)11.9(\032)-7.7(\026)-3.1(\020)-5.1(\n\031\021)]TJ /Span<>> BDC 3.352 0 Td ( )Tj EMC [(\036)12.8(.)-2.7(\003)-12.2(.)]TJ /T1_1 1 Tf 0.018 Tc -0.018 Tw -3.352 -1.218 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf 0.002 Tc -0.002 Tw 11.349 0 Td [( \225)18.6(\020)-3.2(\f)11.1(\020)2.9(\203)13(\t)12.2(\025)]TJ /Span<>> BDC 3.727 0 Td ( )Tj EMC [(\003.)9.3(\003.)]TJ /T1_1 1 Tf -15.076 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \004)8.8(\031)10.1(\f)3.4(\031)9.6(\021)5.5(\022)7.2(\025)10.7(\n)12.7(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)28.6(\211)24.3(.)7.8(, \220)8.4(\031)4.9(\032\031)5.3(\025)10.1(\022)7.2(\025)]TJ /Span<>> BDC ( )Tj EMC [(\001)28.9(.)28.5(\211)24.3(.)]TJ /T1_1 1 Tf -7.694 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.024 Tc 0.024 Tw [( \004)-15.2(\031)-13.9(\f)-20.7(\031)-14.4(\021)-18.4(\022)-16.8(\025)-13.3(\n)-11.3(\022)-16.8(\025)]TJ /Span<>> BDC 12.224 0 Td ( )Tj EMC [(\211.)4.5(\211.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw -12.224 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.081 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.5(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-19.9(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf -0.008 Tc 0.089 Tw [( V)17.9(a)-12.5(d)-6.6(im)]TJ /Span<>> BDC 16.442 0 Td ( )Tj EMC [(V)45.1(.)]TJ /Span<>> BDC 1.036 0 Td ( )Tj EMC [(P)17(o)-9.1(l)-5.1(o)-8.6(v)-36.6(ink)-26.5(in)-14(,)-8( )]TJ 0.008 Tw -17.478 -1.218 Td [(Nik)4.9(o)-9(l)-4.7(a)-13.9(y)]TJ /Span<>> BDC 2.904 0 Td ( )Tj EMC [(V)45.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(D)-14.1(o)-6.7(r)-5.6(o)-7.5(n)-1.8(in)5.6(.)]TJ /T1_1 1 Tf 0 Tc 0.194 Tw -3.859 -1.218 Td [(D)-1.6(a)-8.4(t)-27.7(a c)3.7(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.4(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.8(g)9(:)]TJ /T1_4 1 Tf -0.008 Tc 0.202 Tw [( V)17.9(a)-12.5(d)-6.6(i)0.5(m)]TJ /Span<>> BDC 16.215 0 Td ( )Tj EMC [(V)45.2(.)]TJ /Span<>> BDC 1.149 0 Td ( )Tj EMC [(P)17(o)-9(l)-5.1(o)-8.6(v)-36.6(ink)-26.5(i)0.5(n)-14(,)-8( )]TJ 0 Tc 1.094 Tw -17.364 -1.218 Td [(N)8(i)7.9(k)12.9(o)-1(l)3.3(a)-5.9(y)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(D)-6.1(o)1.3(r)2.4(on)6.2(i)8.4(n)-6(, R)10.2(us)9.3(l)3.3(a)-0.8(n M)5.4(.)47.2(-)-8.2(A)-12.6(. S)15.4(h)6.2(i)9.4(r)7.7(al)4.3(iy)0.9(e)-4(v)33.6(, )]TJ 0 Tw T* [(V)25.9(al)4.8(e)-1.7(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(B)10.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)12.8(a)1.8(us)9.6(h)4.9(a)-0.8(n)8.1(s)9.1(k)-18.5(iy)16.5(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(E)22(r)-14.6(m)4.3(a)1.7(k)12.9(ov)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.028 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \031\006\027\025\n\022 \n\020\007\027\ \024\023\021\020 \255\022\016\025\022 \033\020\006\022\027\025\023\031\021\ \024\032\020\021\025\022\021\020\027\026\013\200 \b\032\r\033\033 \024)Tj /Span<>> BDC ( )Tj EMC (\033\031\026\031\212\017\005 \027\021\032\031\033\027\235\024\n\031\b\031\ \031\033\032\031\024\025\022\n\020 \n\020)Tj 0 Tw (-)Tj 0 -1.2 TD (\007\027\024\023\021\020 \255\022\016\025\022 EQ-5D \021)Tj /Span<>> BDC ( )Tj EMC (\021\027\032\024\022\022 EQ-5D-3L)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.115 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.088 Tw 3.417 0 Td [( R)2.8(e)-22(s)6.7(u)-1.6(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-7.2(s)-10.5(s)0.5(e)-22(s)-10.5(s)-12.5(i)3.9(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(q)-3(ua)-4.5(li)-3.4(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(li)5.1(f)-13.4(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.9(o)-4(m)-1(p)-6.3(a)-4.2(r)-2(e)-12.9(d g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.8(s u)-4.4(s)-12.5(i)3.9(n)-0.6(g t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(E)20.6(u)1.6(r)-2(o)-5.3(p)-11.3(e)-7.5(a)-5.1(n E)21.9(Q)-31.4(-5)13.8(D Q)-10.1(ua)-4.5(li)-3.4(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(L)-1.2(i)5.1(f)-13.4(e )]TJ 0 Tw -3.417 -1.2 Td [(q)-3(u)-3.2(e)-22(s)-14.8(t)-29.1(i)-1.3(o)-4(n)0.8(na)-6.3(i)4.9(r)-2(e i)3.9(n t)-10.6(h)-2.3(e)]TJ /Span<>> BDC ( )Tj EMC [(E)21.9(Q)-31.4(-5)13.8(D)-28.5(-)22.7(3)18(L v)2.3(e)-6(r)-14.8(s)-12.5(i)-1.4(o)-4(n)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 693.581 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 241.1949 693.581 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 303.5571 693.581 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 374.4232 693.581 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.124 693.581 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 663.1618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 662.9118 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 662.9118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 662.9118 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 662.9118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 662.9118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 642.0925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 641.8425 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 641.8425 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 641.8425 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 641.8425 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 641.8425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 621.0233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 620.7733 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 620.7733 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 620.7733 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 620.7733 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 620.7733 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 599.9541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 599.7041 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 599.7041 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 599.7041 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 599.7041 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 599.7041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 578.8849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 578.6349 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 578.6349 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 578.6349 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 578.6349 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 578.6349 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 557.8157 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 557.5657 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 42.7697 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 241.1949 557.5657 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 241.1949 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 303.5571 557.5657 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 303.5571 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 557.5657 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 557.5657 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 536.7465 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 536.4965 cm 0 0 m 198.675 0 l S Q q 1 0 0 1 241.1949 536.4965 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 303.5571 536.4965 cm 0 0 m 70.866 0 l S Q q 1 0 0 1 374.4232 536.4965 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 448.124 536.4965 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 120.5865 675.3465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.557 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_5 1 Tf 2.091 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj -0.01 Tw 5.578 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_5 1 Tf 0 Tw 2.749 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.204 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_5 1 Tf 1.724 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_5 1 Tf 6.484 1.2 Td (\t)Tj /T1_3 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (D1-\200\002\240\t\202\b\002\217\003\001 EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.612 0.001 Td (1,5)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.669 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,37)Tj /T1_3 1 Tf -52.484 -2.635 Td (D2-\255\004\214\002\002\206\217\f\210\202\t\004\b\t\r EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.327 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,34)Tj /T1_3 1 Tf -0.004 Tw -52.484 -2.635 Td [(D3-\032\220\003\t\b\002\217\003\001 )0.5()]TJ /Span<>> BDC ( )Tj EMC 7.475 0 Td [(\212\002\217\r\240\b\r\b\002\005 )0.5(\202\t\213\b\t )0.5(EQ-5D-3L,)]TJ /T1_4 1 Tf [( )0.5(\240\020\f\f\013)]TJ 0 Tw -7.475 -1.2 Td (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.327 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,24)Tj /T1_3 1 Tf -52.484 -2.635 Td (D4-\224\002\f\001 \t)Tj /Span<>> BDC ( )Tj EMC (\240\t\217\220\002\214\226\002\006\003 EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;1\))Tj 8.327 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 7.301 1.2 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_3 1 Tf -51.618 -2.635 Td (D5-\224\r\217\212\002\220\002\005\217\003\002 \t\f\t \240\r\212\006\r\217\ \217\t\235 EQ-5D-3L,)Tj /T1_4 1 Tf ( \240\020\f\f\013)Tj 0 -1.2 TD (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.954 0.001 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.327 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 9.035 0 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(1;2\))Tj 8.168 1.2 Td (0,54)Tj /T1_3 1 Tf -52.484 -2.635 Td (EQ-VAS, )Tj /T1_4 1 Tf (\240\020\f\f\013)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 26.204 0.001 Td (80)Tj /Span<>> BDC ( )Tj EMC (\(70;85\))Tj 8.327 0 Td (70)Tj /Span<>> BDC ( )Tj EMC (\(65;75\))Tj 9.035 0 Td (70)Tj /Span<>> BDC ( )Tj EMC (\(65;75\))Tj 8.051 1.2 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_4 1 Tf 7 0 0 7 42.5197 525.0118 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.8644 56.0378 Tm (89)Tj ET endstream endobj 1102 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.138 Tw 10 0 0 10 70.8661 578.6938 Tm (\031\001\017\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\031 \(14% \(7/50\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 )Tj 0.167 Tw 0 -1.218 TD (\f\036\021\004\026\021\024\020\024 \220\027\007\024\023\030\024\021\036\ \026 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.167 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07\). \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\007\036\021\026\035\017\026\006\017\017 )Tj 0.366 Tw T* (\f\021\030\031\022\021\031\030\t \023\024\007\027\017\b \024\f\035\024\032\ \027\036\027\017\005 \027\026\002\035\033\007\026\036\021\f\016 \021\036\ \027)Tj 0 Tw (-)Tj 0.009 Tw 0 -1.218 TD (\007\036\027\006\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \004\026\f\021\024\021\t \017\b \r\024\027\ \017\022\027\024\r\036\027\017\016 \023\024\f\035\036 )Tj 0 Tw 0 -1.218 TD (\023\030\017\n\036\027\036\027\017\016 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 \023\035\026\f\021\017\022\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\))Tj 0.002 Tc 0.504 Tw 0 -1.218 TD (\222\035\024\032\027\024\f\021\017 \f)Tj /Span<>> BDC ( )Tj EMC [(\026\032\017\r\035\036\027\017\036\n \023\030\024\n\036\032\027\024\f\021\ \027\024\005 \030\026\027\t)2( )]TJ 0.59 Tw 0 -1.218 TD [(\f\021\026\035\017 \023\030\017\004\017\027\024\005 \007\035\016 \023\024\ \r\021\024\030\027\024\005 \020\024\f\023\017\021\026\035\017\026\006\017\ \017)2( )]TJ 0.228 Tw 0 -1.218 TD (\r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024)Tj /Span<>> BDC ( )Tj EMC 3.757 0 Td (\027\026\030 \r)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\020\024 \f\023\024\f\024\002\026)2( )]TJ 0.066 Tw -3.757 -1.218 Td [(\023\035\026\f\021\017\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.846 0 Td [(2% )0.5(\(1/50\) )0.5(\027\026\002\035\033\007\036\027\017\005, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 10.982 0 Td [(\020\030\031\023\023\036 )0.5(\023\030\024\f\021\024)]TJ 0 Tc 0 Tw (-)Tj 0.002 Tc 0.154 Tw -15.828 -1.218 Td (\020\024 \031\001\017\r\026\027\017\016 \030\026\027\t \021\026\022\032\036\ \r)Tj /Span<>> BDC ( )Tj EMC [(2% \(1/50\) \027\026\002\035\033\007\036\027\017\005.)2( )]TJ 0.218 Tw 0 -1.218 TD (\215\026\006\017\036\027\021\026\n, \031)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\b \023\030\017\n\036\027\016\035\026\f\034 \023\035\ \026\f\021\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.317 Tw T* (\023\024\035\034\024\r\026\027\017\036\n \f\036\021\004\026\021\024\020\ \024 \220\027\007\024\023\030\024\021\036\026, \027\017 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\007\027\024\n)2( )]TJ 0.097 Tw T* [(\f\035\031\004\026\036 \027\036 \023\024\021\030\036\002\024\r\026\035\026\ \f\034 \023\024\r\021\024\030\027\026\016 \020\024\f\023\017\021\026\035\ \017\026\006\017\016)2( )]TJ 0 Tc 0 Tw T* (\()Tj /T1_1 1 Tf 0.372 0 Td (\032)Tj /T1_0 1 Tf 0.002 Tc /Span<>> BDC 0.48 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,60\).)Tj 0 Tc 0.123 Tw -0.852 -1.218 Td (\207\024\035\036\r\024\005 \f\017\027\007\030\024\n, \f\024\b\030\026\027\ \016\033\013\017\005\f\016 \002\024\035\036\036 3 \n\036\f\016\006\036\r\ , )Tj 0.215 Tw T* (\030\036\032\036 \027\026\002\035\033\007\026\035\f\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 )Tj 0.204 Tw T* (\023\035\026\f\021\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\t\n \031\001\017\r\026\027\017\036\n \030\026\027\t, \ )Tj 0.142 Tw T* [(\027\024 \f\021\026\021\017\f\021\017\004\036\f\022\026\016 \027\026\004\ \017\n\024\f\021\034 )0.5(\220\021\024\020\024 \024\021\035\017\004\017\016 )0.5(\027\036 \007\024)]TJ 0 Tw (-)Tj 0.08 Tw T* (\f\021\017\020\027\031\021\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \023\035\026\f\021\017\022\ \017 \f\036\021\004\026\021\t\n \220\027)Tj 0 Tw (-)Tj 0.246 Tw T* (\007\024\023\030\024\021\036\024\n \004\026\f\021\024\021\026 \r\f\021\030\ \036\004\026\036\n\024\f\021\017 \220\021\024\020\024 \f\017\027\007\030\ \024\n\026 )Tj 0.169 Tw T* (\002\t\035\026 \023\030\026\022\021\017\004\036\f\022\017 \021\026\022\026\ \016 \032\036, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017 \023\030\017\n\036\027\036\027\017\017 )Tj 0 Tw T* (\027\024\r\024\020\024 \f\023\024\f\024\002\026 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (5\).)Tj /T1_2 1 Tf 0 -2.436 TD (\017\204\r\b\220\004 \220\004\201\r\217\003\004 \202\t\213\b\t \212\004\ \204\t\r\b\003\002)Tj /T1_0 1 Tf -0.05 Tw 0 -1.218 TD [(\200 \030\036\031\035\034\021\026\021\036 \026\027\026\035\017\026 )0.5(\f\021\030\031\022\021\031\030\t \024\006\036\027\022\017 )0.5(\022\026\004\036\f\021\r\026 \032\017)]TJ 0 Tw (-)Tj 0.062 Tw T* [(\027\017 )0.5(\031\f\021\026\027\024\r\035\036\027\024, )0.5(\004\021\024 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 9.906 0 Td [(\022\024\n\023\024\027\036\027\021\026\n )0.6(\253\215\024\007\r\017\032\027\024\f\021\034\273 )]TJ 0.218 Tw -9.906 -1.218 Td (\(D1\), \253\222\026\n\024\024\002\f\035\031\032\017\r\026\027\017\036\273\ \(D2\), \253\202\022\021\017\r\027\024\f\021\034 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024)Tj 0 Tw (-)Tj 0.233 Tw T* (\r\f\036\007\027\036\r\027\024\005 \032\017\027\017\273 \(D3\) \017)Tj /Span<>> BDC ( )Tj EMC (\253\207\036\f\023\024\022\024\005\f\021\r\024 \017\035\017 \007\036)Tj 0 Tw (-)Tj 0.12 Tw T* (\023\030\036\f\f\017\016\273 \(D5\) \f\030\026\r\027\017\r\026\036\n\t\036\ \020\030\031\023\023\t \027\036 \024\021\035\017\004\026\035\017\f\034,\ )Tj 0.168 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\017\005 \002\026\035\035 \024\006\036\027\022\017 \027\ \026\b\024\007\017\035\f\016 \002\035\017\032\036 \022)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\033 )Tj 0.649 Tw T* (\253\027\036\027\026\004\017\021\036\035\034\027\026\016 \023\030\024\002\ \035\036\n\026\273. \222\021\026\021\017\f\021\017\004\036\f\022\017 \027\ \026)Tj 0 Tw (-)Tj 0.196 Tw T* (\004\017\n\024\036 \024\021\035\017\004\017\036 \f\030\036\007\027\017\b\ \027\026\004\036\027\017\005 \002\026\035\035\034\027\024\005 \024\006\ \036\027\022\017 )Tj 0.134 Tw T* (\002\t\035\024 \r\t\016\r\035\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\022\024\n\023\024\027\036\027\021\036 \253\207\024\035\034 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\022\024\n\235\024\030\021\273 )Tj 0.05 Tw T* (\(D4\). \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\020\024 \f\023\024\f\024\002\026 \023\035\026\f\021\017\022\017 )Tj -0.044 Tw 0 -1.218 TD (\f\030\036\007\027\017\005 \002\026\035\035 \024\006\036\027\022\017 \002\ \t\035 \023\030\026\022\021\017\004\036\f\022\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 \253\027\036)Tj 0 Tw (-)Tj 0 -1.218 TD (\027\026\004\017\021\036\035\034\027\026\016 \023\030\024\002\035\036\n\ \026\273, \021\024\020\007\026 \022\026\022 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\030\024\f\021\024)Tj (-)Tj 0.098 Tw 0 -1.218 TD (\020\024 \031\001\017\r\026\027\017\016 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\016 \023\035\026\f\021\017\022\017 \f\ \036\021\004\026\021\t\n )Tj 0.104 Tw 0 -1.218 TD [(\220\027\007\024\023\030\024\021\036\024\n )0.6(\002\035\017\032\036 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 9.892 0 Td [(\031\030\024\r\027\033 )0.5(\253\027\026\004\017\021\036\035\034\027\026\016 )0.7(\023\030\024\002)]TJ 0 Tw (-)Tj -9.892 -1.218 Td (\035\036\n\026\273 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.153 Tw 0 -1.218 TD (\025\030\024\n\036 \021\024\020\024, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\017\r\026\036\n\t\b \020\030\031\023\023\026\b \r\t\016\ \r\035\036\027\024 \f\021\026)Tj 0 Tw (-)Tj 0.52 Tw 0 -1.218 TD [(\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024\036 )0.5(\024\021\035\017\004\017\036 \f\030\036\007\027\017\b \027\026\004\036\027\ \017\005 )]TJ 0.357 Tw 0 -1.218 TD (\030\036\005\021\017\027\020\026 \021\036\022\031\013\036\020\024 \f\024\ \f\021\024\016\027\017\016 \007\024\030\024\r\034\016. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj -0.077 Tw 23.244 49.93 Td (\023\030\017\n\036\027\036\027\017\016 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 \023\035\026\f\021\017\022\017 \023\026\006\017\036\027\021\ \t \f\031\013\036)Tj 0 Tw (-)Tj 0.129 Tw 0 -1.218 TD [(\f\021\r\036\027\027\024 )0.6(\r\t\001\036 )0.5(\024\006\036\027\017\r\026\035\017 )0.5(\021\036\022\031\013\036\036 )0.6(\f\024\f\021\024\016\027\017\036 )0.5(\007\024\030\024)]TJ 0 Tw (-)Tj -0.005 Tw T* (\r\034\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \023\030\017\n\036\027\036\027\017\016 )Tj 0.089 Tw 0 -1.218 TD (\023\030\024\f\021\024\020\024 \031\001\017\r\026\027\017\016 \030\026\027\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t, \020\007\036 \023\030\017\n\036\027\016\035\026\f\ \034 )Tj 0 Tw 0 -1.218 TD (\023\035\026\f\021\017\022\026 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024\021\036\024\n \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.415 Tw 10 0 0 10 303.3071 469.0918 Tm (\217\036\031\035\034\021\026\021\t \023\030\036\007\f\021\026\r\035\036\ \027\027\024\020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \f\r\017\ \007\036)Tj 0 Tw (-)Tj 0.159 Tw 0 -1.218 TD (\021\036\035\034\f\021\r\031\033\021 \024)Tj /Span<>> BDC ( )Tj EMC (\021\024\n, \004\021\024 \023\030\036\007\035\024\032\036\027\027\t\005 \ \027\024\r\t\005 \f\023\024\f\024\002 )Tj 0.017 Tw T* (\023\035\026\f\021\017\022\017 \023\030\024\n\036\032\027\024\f\021\027\024\ \005 \030\026\027\t \016\r\035\016\036\021\f\016 \023\036\030\f\023\036\022\ \021\017\r)Tj 0 Tw (-)Tj 0.155 Tw T* (\027\024\005 \n\036\021\024\007\017\022\024\005 \030\036\022\024\027\f\021\ \030\031\022\006\017\017 \023\024\f\035\036 \233\035\207\215\233 \023\030\ \016\n\024\005 )Tj 0.205 Tw T* (\022\017\001\022\017. \203\036\f\n\024\021\030\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\r\036\035\017\004\036\027\017\036 \r\030\036\n\036\027\017, \026\021\ \030\026\004\017)Tj 0 Tw (-)Tj 0.132 Tw T* (\r\026\036\n\024\020\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\004\036\f\022\017\005 \220\021\026\023, \004\021\024\ \016\r\035\016\036\021\f\016 \024\032\017\007\026)Tj 0 Tw (-)Tj 0.031 Tw T* (\036\n\t\n \007\035\016 \002\024\035\036\036 \021\036\b\027\017\004\036\f\ \022\017 \f\035\024\032\027\t\b \030\036\022\024\027\f\021\030\031\022\006\ \017\005, )Tj -0.014 Tw T* [(\036\020\024 )0.5(\023\030\017\n\036\027\036\027\017\036 )0.5(\023\024\r\024\035\016\036\021 )0.6(\007\024\f\021\017\004\034 )0.5(\030\016\007\026 )0.5(\022\035\017\027\017\004\036\f\022\017\b )]TJ 0 Tw T* (\023\030\036\017\n\031\013\036\f\021\r.)Tj 0.087 Tw T* (\203\026\017\002\024\035\036\036 \r\026\032\027\t\n \017)Tj /Span<>> BDC ( )Tj EMC [(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.5(\023\024\007\021\r\036\030\032\007\201\027\027\t\n )]TJ 0.335 Tw T* [(\023\030\036\017\n\031\013\036\f\021\r\024\n )0.6(\016\r\035\016\036\021\f\016 )0.5(\f\027\017\032\036\027\017\036 )0.6(\017\027\021\036\027\f\017\r\027\024\f\021\017 )]TJ 0.09 Tw T* (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\005 \002\024\ \035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\017\005 \023\036\030\017\024\007. \204\t \f\r\016)Tj 0 Tw (-)Tj -0.036 Tw T* [(\t\r\026\036\n \220\021\024\021 )0.5(\220\235\235\036\022\021 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\023\030\017\027\006\017\023\017\026\035\034\027\024 )0.5(\017\027\t\n )0.5(\023\024\007\b\024\007\024\n )]TJ -0.033 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\026\022\030\t\021\017\033 \007\036\235\036\022\021\026. \200)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 \023\030\024\f\021\024\020\024 \031\ \001\017\r\026\027\017\016 )Tj 0.047 Tw T* (\030\026\027\t, \f\024\002\f\021\r\036\027\027\024, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\017 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024)Tj 0 Tw (-)Tj 0.072 Tw T* (\021\036\024\n, \021\030\036\002\031\033\013\017\b \023\024\f\035\024\005\ \027\024\020\024 \f\024\023\024\f\021\026\r\035\036\027\017\016 \021\022\ \026\027\036\005 )Tj -0.035 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\016\032\036\027\017\036\n, \027\024\r\t\005 \n\036\021\024\007\ \023\024\r\024\035\016\036\021 \017\002\036\032\026\021\034 \220\021\024\ \020\024 )Tj 0.225 Tw T* (\027\036\032\036\035\026\021\036\035\034\027\024\020\024 \220\235\235\036\ \022\021\026 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\201\021 \023\036\030\036\n\036\013\036\027\017\016 \035\024)Tj 0 Tw (-)Tj 0.154 Tw T* (\f\022\031\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\026\023\024\035\027\036\027\017\016 \253\n\201\030\021\r\024\020\024\273\ \023\030\024\f\021\030\026\027\f\021\r\026 \024\002\255)Tj 0 Tw (-)Tj 0.442 Tw T* (\201\n\027\t\n\017, \b\024\030\024\001\024 \r\026\f\022\031\035\016\030\017\ \017\030\024\r\026\027\027\t\n\017 \021\022\026\027\016\n\017. )Tj 0.373 Tw T* (\233\021\024 \023\024\035\027\024\f\021\034\033 \f\024\024\021\r\036\021\ \f\021\r\031\036\021 \024\002\013\036\b\017\030\031\030\020\017\004\036\f\ \022\024\n\031 )Tj 0.102 Tw T* (\023\030\017\027\006\017\023\031)Tj /Span<>> BDC ( )Tj EMC 4.338 0 Td [(\227 )0.5(\030\036\022\024\027\f\021\030\031\022\006\017\016 )0.6(\002\036 )0.5(\027\026\021\016\032\036\027\017\016, )0.6(\f\023\024\f\024\002)]TJ 0 Tw (-)Tj 0.15 Tw -4.338 -1.218 Td (\f\021\r\031\016 \031\f\023\036\001\027\024\n\031 \026\032\017\r\035\036\ \027\017\033 \017)Tj /Span<>> BDC ( )Tj EMC (\f\027\017\032\036\027\017\033 \002\024\035\036\r\024\005 )Tj 0 Tw T* (\017\n\023\031\035\034\f\026\006\017\017 [24].)Tj 0.144 Tw T* (\025\030\024\n\036 \021\024\020\024, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\024\n \031\001\017\r\026\027\017\017 \030\026\027\t \021\ \026\022\032\036 \022\026\022 )Tj 0.208 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\017 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024\021\036\024\n \f\031\013\036\f\021\r\031\036\021 \r\t)Tj 0 Tw (-)Tj 0.072 Tw T* (\f\024\022\017\005 \030\017\f\022 \030\026\r\017\021\017\016 \030\026\027\ \036\r\024\005 \017\027\235\036\022\006\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\f\024\f\021\024\016)Tj 0 Tw (-)Tj 0.267 Tw T* [(\021\036\035\034\027\024\f\021\017 )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\001\r\026. )0.5(\230\f\f\035\036\007\024\r\026\027\017\036 )]TJ 0.036 Tw T* [(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\023\036\030\r\017\004\027\024\020\024 \023\030\024\f\021\024\020\024 \031\ \001\017\r\026\027\017\016, \023\030\024)]TJ 0 Tw (-)Tj 0.02 Tw T* (\r\036\007\036\027\027\024\036 \r)Tj /Span<>> BDC ( )Tj EMC (1975 \020\024\007\031 [25], \023\024\022\026\026\035\024, \004\021\024 \ \026\031\021\024\023\035\026\f\021\017)Tj 0 Tw (-)Tj 0.245 Tw T* [(\022\026 \024\002\036\f\023\036\004\017\r\026\036\021 \026\032\017\r\035\ \036\027\017\036 )0.5(\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t )]TJ 0.02 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 3 \n\036\f\016\006\036\r \r)Tj /Span<>> BDC ( )Tj EMC (67\22668% \027\026\002\035\033\007\036\027\017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\r \021\036\004\036)Tj 0 Tw (-)Tj 0.068 Tw T* (\027\017\036 6 \n\036\f\016\006\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (80%. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\007\036\027\017\017 \024\021\022\030\t\021\024\020\024\ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 5.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \004\031\016\030\025\022\027 \031\024\f\031\255\025\027\025\022\t \016\020\ \255\022\021\f\027\025\022\t \033\032\031\026\027\255\025\031\024\023\025\ \031\235 \032\020\025\013 \r)Tj /Span<>> BDC ( )Tj EMC 28.685 0 Td (\033\020\006\022\027\025\023\031\021 \b\032\r\033\033 \024\032\020\021\025\ \027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw -28.685 -1.2 Td [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.323 0 Td [( L)-8.8(a)-9.2(t)-1.5(e c)2.8(o)-4(m)-1(p)-4.9(li)-1.8(c)3.3(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-11.3(e)-5.9(r)-39(i)3.9(n)-2.4(e)-7.5(a)-4.5(l w)2.2(o)-3.4(u)0.7(n)-4.9(d h)-2.3(e)-7.5(a)-4.5(li)3.9(n)-0.6(g i)3.9(n p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e c)2.8(o)-4(m)-1(p)-6.3(a)-4.1(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.9(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.9351 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 684.5118 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 246.8642 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 323.3996 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 399.9351 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 476.4705 684.5118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 524.6594 625.2926 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 70.8661 625.0426 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 625.0426 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 625.0426 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 625.0426 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 625.0426 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 613.8234 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 613.5734 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 613.5734 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 613.5734 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 613.5734 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 476.4705 613.5734 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 137.5944 696.9465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.025 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_4 1 Tf 2.091 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.813 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_4 1 Tf 2.754 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.736 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_4 1 Tf 1.724 -1.2 Td (n)Tj /T1_2 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_4 1 Tf 6.661 1.2 Td (\t)Tj /T1_2 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (\200\002\213\240\b\t\r \002\217\f\002\202\b\r\b\t\235 \213\004\202\t\f\r\ \b\t\235 )Tj 0 -1.2 TD (\212\006\002\214\r\202\b\002\217\003\b\002\005 \006\004\b\013)Tj /T1_0 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj T* (\026\002\f\006\036\f\f)Tj T* (\f\r\017\013)Tj T* (\020\030\t\032\026)Tj 23.469 3.601 Td (49)Tj /Span<>> BDC ( )Tj EMC (\(98%\))Tj 1.616 -1.2 Td (0)Tj T* (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.067 3.6 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj T* (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 9.067 3.6 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 1.616 -1.2 Td (0)Tj -1.116 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj T* (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 8.319 6 Td (0,22)Tj /T1_2 1 Tf -52.484 -7.435 Td (\224\002\f\r\002\005 \217\t\b\240\006\002\214 \206\002\f\r\r 3 \214\r\217\ \235\204\r)Tj /T1_0 1 Tf 25.032 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 9.317 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.817 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 8.319 0 Td (0,28)Tj /T1_1 1 Tf 7 0 0 7 70.8661 602.0887 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC (\227 \n\032\022\023\027\032\022\235 \250)Tj 4.081 0 0 4.081 156.7616 604.4197 Tm (2)Tj 7 0 0 7 158.8021 602.0887 Tm ( \004\022\032\024\031\025\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_6 1 Tf 25 0 0 25 28.1526 56.0378 Tm (88)Tj ET endstream endobj 1101 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.08 Tw 10 0 0 10 42.5197 262.0659 Tm (\217\026\027\027\017\036 \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\036 \024\f\035\024\032\027\036\027\017\016 \f\024 \f\021\024\030\ \024\027\t )Tj -0.105 Tw 0 -1.218 TD (\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t \023\024\ \f\035\031\032\017\035\017 \023\030\017\004\017\027\024\005 \023\024\r\021\ \024\030\027\024\005 )Tj -0.029 Tw T* (\024\023\036\030\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (6% \(3/50\) \027\026\002\035\033\007\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036)Tj 0 Tw (-)Tj -0.02 Tw T* [(\027\017\016 )0.6(\027\024\r\024\020\024 )0.5(\f\023\024\f\024\002\026 )0.5(\023\035\026\f\021\017\022\017, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 13.174 0 Td [(10% )0.5(\(5/50\))]TJ /Span<>> BDC ( )Tj EMC 4.867 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 1.899 0 Td (\020\030\031\023)Tj 0 Tw (-)Tj 0.005 Tw -19.94 -1.218 Td (\023\036 \023\030\024\f\021\024\020\024 \031\001\017\r\026\027\017\016 \017\ )Tj /Span<>> BDC ( )Tj EMC (\r 12% \(6/50\))Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\f)Tj 0 Tw (-)Tj T* (\023\024\035\034\024\r\026\027\017\016 \f\036\021\004\026\021\024\020\024\ \220\027\007\024\023\030\024\021\036\026 \030\026\027\t \()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,58\).)Tj 0.352 Tw T* [(\210\021\027\024\f\017\021\036\035\034\027\024 )0.6(\021\016\032\036\f\021\017 )0.5(\030\026\027\027\017\b )0.5(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b )]TJ 0.837 Tw T* [(\024\f\035\024\032\027\036\027\017\005, )0.6(\f\024\020\035\026\f\027\024 )0.5(\022\035\026\f\f\017\235\017\022\026\006\017\017 )0.6(Cl)-16(av)-15.9(ien\226)]TJ 0.146 Tw T* [(Dind)-16(o, \024\f\035\024\032\027\036\027\017\016 II \017)]TJ /Span<>> BDC ( )Tj EMC (IV \f\021\036\023\036\027\017 \r\024 \r\f\036\b \f\030\026\r\027\017)Tj 0 Tw (-)Tj 0.06 Tw T* (\r\026\036\n\t\b \020\030\031\023\023\026\b \r\f\021\030\036\004\026\035\ \017\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\017\027\026\022\024\r\024\005 \004\026\f\021\024\021\024\005. )Tj 0.003 Tw T* [(\217\026\035\017\004\017\016 )0.5(\002\t\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\004\026\f\021\024\021\036 )0.5(\024\f\035\024\032\027\036\027\017\005 )0.5(I )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 17.176 0 Td [(III )0.5(\f\021\036\023\036\027\017. )]TJ 0.095 Tw -17.176 -1.218 Td (\200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\020\024 \f\023\024\f\024\002\026 \023\035\026\f\021\017\022\017 \023\ \030\036)Tj 0 Tw (-)Tj 0.273 Tw T* (\024\002\035\026\007\026\035\017 \024\f\035\024\032\027\036\027\017\016 \ I \f\021\036\023\036\027\017, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\026 \030\026\r\017)Tj 0 Tw (-)Tj 0.088 Tw T* (\021\017\016 \024\f\035\024\032\027\036\027\017\005 IIIa-IIIb \002\t\035\ \026 \027\036\f\022\024\035\034\022\024 \027\017\032\036, \004\036\n )Tj 0.004 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\030\024\f\021\024\020\024 \031\001\017\r\ \026\027\017\016 \030\026\027\t \017\035\017 \023\035\026\f\021\017\022\017\ \f\036\021)Tj 0 Tw (-)Tj T* (\004\026\021\t\n \220\027\007\024\023\030\024\021\036\024\n \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj /T1_3 1 Tf 1.651 Tw 23.244 18.267 Td (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\002\r \212\006\r\206\013\ \004\b\t\r \212\004\204\t\r\b\003\004 )Tj 0 Tw T* ()Tj /Span<>> BDC ( )Tj EMC (\217\003\004\204\t\002\b\004\006\r)Tj /T1_1 1 Tf 1.156 Tw T* (\210\002\013\017\005 \022\024\005\022\024-\007\036\027\034 \(14,5[13;17]\ ; 15,5[14;20]; )Tj 0 Tw T* (15[13;20], )Tj /T1_2 1 Tf 4.516 0 Td (p)Tj /T1_1 1 Tf 0.047 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,18\), \021\026\022\032\036, \022\026\022 \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )Tj 0.312 Tw -4.516 -1.218 Td (\023\030\036\002\t\r\026\027\017\016 \023\026\006\017\036\027\021\026 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\027\024\005 \022\024\005\022\036 \023\ \024)Tj 0 Tw (-)Tj 0.281 Tw T* [(\f\035\036 \024\023\036\030\026\006\017\017 )0.5(\(11,5[10;14]; 13[11;15]; )0.5(12,5[10;16], )]TJ /T1_2 1 Tf 0 Tw T* (p)Tj /T1_1 1 Tf 0.258 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,20\) \027\036 \017\n\036\035\017 \f\021\026\021\017\f\021\017\004\036\f\ \022\017 \027\026\004\017\n\t\b \024\021\035\017)Tj 0 Tw (-)Tj 0.362 Tw T* (\004\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \023\030\017\n\036\027\036\027\017\016 \027\024\ \r\024\005 \023\035\026\f\021\017\022\017, \023\030\024)Tj 0 Tw (-)Tj 0.167 Tw T* (\f\021\024\020\024 \031\001\017\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\f\021\017\022\017 \f\036\021\004\026\021\t\n \220\027\007\024\ \023\030\024\021\036\024\n )Tj 0 Tw T* (\(\f\024\024\021\r\036\021\f\021\r\036\027\027\024\).)Tj /T1_3 1 Tf 0.013 Tw 0 -2.436 TD (\200\002\213\240\b\t\r \002\217\f\002\202\b\r\b\t\235 \213\004\202\t\f\r\ \b\t\235 \212\006\002\214\r\202\b\002\217\003\b\002\005 )Tj 0 Tw 0 -1.218 TD (\006\004\b\013)Tj /T1_1 1 Tf 0.418 Tw T* (\215\024\007\027\017\036 \024\f\035\024\032\027\036\027\017\016 \f\024 \ \f\021\024\030\024\027\t \023\030\024\n\036\032\027\024\f\021\027\024\005\ )Tj 0.022 Tw T* (\030\026\027\t \030\026\r\017\035\017\f\034 \031)Tj /Span<>> BDC ( )Tj EMC (2% \(1/50\) \023\026\006\017\036\027\021\024\r \020\030\031\023\023\t \027\ \024\r\024)Tj 0 Tw (-)Tj 0.117 Tw T* [(\020\024 )0.5(\f\023\024\f\024\002\026 )0.6(\023\035\026\f\021\017\022\017, )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.995 0 Td [(14% )0.5(\(7/50\) )0.6(\020\030\031\023\023\t )0.5(\023\030\024\f\021\024\020\024 )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \031\006\027\025\n\022 \022\025\023\ \027\025\024\022\021\025\031\024\023\022 \240\031\f\027\021\031\b\031 \024\ \022\025\030\032\031\026\020 \021)Tj /Span<>> BDC ( )Tj EMC 29.115 0 Td (\b\032\r\033\033\020\200 \024\032\020\021\025\027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw -29.115 -1.2 Td [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.8(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.318 0 Td [( R)2.8(e)-22(s)6.7(u)-1.5(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-6.3(i)3.9(n s)-14.7(y)-4.8(n)-4.8(d)0.8(r)-2(o)-4(m)-5.3(e i)4(n)-0.6(t)-1.6(e)-7(n)3.7(s)-12.5(i)-3.4(t)-33.8(y a)-7.2(s)-10.5(s)0.5(e)-22(s)-10.4(s)5.1(m)-5.3(e)-7(n)-0.6(t i)3.9(n c)2.8(o)-3.9(m)-1(p)-6.3(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.3(u)-2.3(p)1.8(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 261.0374 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 317.7303 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 374.4232 715.181 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.124 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 684.5118 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 684.5118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 684.5118 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 684.5118 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 684.5118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 663.6926 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 663.4426 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 663.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 663.4426 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 663.4426 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 663.4426 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 642.6234 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 642.3734 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 642.3734 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 642.3734 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 642.3734 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 642.3734 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 621.3041 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 261.0374 621.3041 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 317.7303 621.3041 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 374.4232 621.3041 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 448.124 621.3041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.124 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 496.313 600.4849 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 600.2349 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 261.0374 600.2349 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 600.2349 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 374.4232 600.2349 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 448.124 600.2349 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 130.5078 696.9465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 18.526 1.2 Td (\025\002\004\235 )Tj -0.633 -1.2 Td (\212\f\004\217\003\t\220\004)Tj /T1_4 1 Tf 0.641 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.638 2.4 Td (\200\006\002\217\003\002\r )Tj -0.414 -1.2 Td (\210\230\t\004\b\t\r)Tj /T1_4 1 Tf 0.863 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 5.319 2.4 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_4 1 Tf 1.724 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_4 1 Tf 6.333 1.2 Td (\t)Tj /T1_3 1 Tf (-\213\b\004\201\r\b\t\r)Tj /T1_4 1 Tf 4.664 0 0 4.664 490.6943 699.6105 Tm (\001)Tj /T1_3 1 Tf 8 0 0 8 45.6044 675.8773 Tm (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 1-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf 0 -1.2 TD (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0;5,0\))Tj 7.087 0 Td (6,0)Tj /Span<>> BDC ( )Tj EMC (\(6,0;7,0\))Tj 8.15 0 Td (6,0)Tj /Span<>> BDC ( )Tj EMC (\(5,0;7,0\))Tj 8.945 1.2 Td (0,005)Tj /T1_3 1 Tf -52.234 -2.635 Td (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 3-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0;5,0\))Tj 7.087 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(5,0;6,0\))Tj 8.15 0 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\(4,0;5,0\))Tj 8.945 1.2 Td (0,002)Tj /T1_3 1 Tf -52.234 -2.635 Td (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 5-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(2,0;4,0\))Tj 7.087 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0;4,0\))Tj 8.15 0 Td (3,0)Tj /Span<>> BDC ( )Tj EMC (\(3,0;4,0\))Tj 8.695 1.2 Td (0,0007)Tj /T1_3 1 Tf -51.984 -2.635 Td (\255\006\r\240\b\t\005 \206\004\f\f \201\t\217\f\002\002\005 \006\r\005\ \003\t\b\n\002\002\005 \230\220\004\f\013 \(NRS\) 7-\r \217\210\003\220\ \t)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 28.053 0.001 Td (1,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0;2,0\))Tj 7.087 0 Td (2,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0;2,0\))Tj 8.15 0 Td (1,0)Tj /Span<>> BDC ( )Tj EMC (\(1,0;2,0\))Tj 9.195 1.2 Td (0,08)Tj /T1_2 1 Tf 7 0 0 7 42.5197 588.7503 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 569.4464 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( \206\020\025\025\022\027 \033\031\024\f\027\031\033\027\032\020\006\022\ \031\025\025\013\027 \031\024\f\031\255\025\027\025\022\t \033\032\031\026\ \027\255\025\031\024\023\025\031\235 \032\020\025)0.5(\013 \r)]TJ /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \b\032\r\033\033 \024\032\020\021\025\ \027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.337 0 Td [( E)18(a)-4.2(r)-10.1(l)6.7(y p)-9.1(o)-1.1(s)-14.8(t)-3(o)-5.3(p)-11.3(e)-6(r)3.3(a)-9.1(t)-29.1(i)-2.9(v)2.3(e c)2.8(o)-4(m)-1(p)-4.9(li)-1.7(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-11.2(e)-6(r)-39(i)3.9(n)-2.4(e)-7.5(a)-4.5(l w)2.3(o)-3.4(u)0.6(n)-4.8(d i)3.9(n p)-6.3(a)-9.2(t)-29(i)-1.4(e)-7(n)-0.6(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-3.9(m)-1(p)-6.3(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.3(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 554.1444 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 261.0374 554.1444 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 317.7303 554.1444 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 374.4232 554.1444 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 448.1241 554.1444 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 523.7252 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 523.4752 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 261.0374 523.4752 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 317.7303 523.4752 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 374.4232 523.4752 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 448.1241 523.4752 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 496.313 454.656 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 42.5197 454.406 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 261.0374 454.406 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 317.7303 454.406 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 374.4232 454.406 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 448.1241 454.406 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 496.313 366.3867 cm 0 0 m 0 87.769 l S Q q 1 0 0 1 42.5197 366.1367 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 42.7697 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 261.0374 366.1367 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 261.0374 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 317.7303 366.1367 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 374.4232 366.1367 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 374.4232 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 448.1241 366.1367 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 448.1241 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 496.313 297.3175 cm 0 0 m 0 68.569 l S Q q 1 0 0 1 42.5197 297.0675 cm 0 0 m 218.518 0 l S Q q 1 0 0 1 261.0374 297.0675 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 317.7303 297.0675 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 374.4232 297.0675 cm 0 0 m 73.701 0 l S Q q 1 0 0 1 448.1241 297.0675 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 130.5078 535.9099 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 18.526 1.2 Td (\025\002\004\235 )Tj -0.633 -1.2 Td (\212\f\004\217\003\t\220\004)Tj /T1_4 1 Tf 0.641 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.638 2.4 Td (\200\006\002\217\003\002\r )Tj -0.414 -1.2 Td (\210\230\t\004\b\t\r)Tj /T1_4 1 Tf 0.863 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 5.319 2.4 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_4 1 Tf 1.724 -1.2 Td (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_4 1 Tf 6.484 1.2 Td (\t)Tj /T1_3 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (\017\217\f\002\202\b\r\b\t\235 \212\006\002\214\r\202\b\002\217\003\b\002\ \005 \006\004\b\013)Tj /T1_1 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj 0 -1.2 TD (\f\036\030\024\n\026)Tj T* (\020\036\n\026\021\024\n\026)Tj T* (\027\026\020\027\024\036\027\017\036)Tj T* (\027\036\022\030\024 \035\024\f\022\031\021\026 \002\036 \030\026\f\b\024\ \032\007\036\027\017\016 \022\030\026\036\r \030\026\027\t)Tj T* (\027\036\022\030\024 \035\024\f\022\031\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\b\024\032\007\036\027\017\036\n \022\030\026\036\r \030\026\027\ \t)Tj 27.543 6.001 Td (42)Tj /Span<>> BDC ( )Tj EMC (\(84%\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj T* (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 6.587 6 Td (34)Tj /Span<>> BDC ( )Tj EMC (\(68%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.25 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj -0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 1.366 -1.2 Td (0)Tj T* (0)Tj 6.534 6 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(76%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj -0.25 -1.2 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 1.366 -1.2 Td (0)Tj T* (0)Tj 7.026 7.2 Td (0,43)Tj /T1_3 1 Tf -52.484 -8.635 Td (\017\217\f\002\202\b\r\b\t\235, \b\r \217\235\213\004\b\b\013\r \217)Tj /Span<>> BDC ( )Tj EMC (\212\006\002\214\r\202\b\002\217\003\b\002\005 \006\004\b\002\005)Tj /T1_1 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj T* (\007\017\f\235\031\027\022\006\017\016 \n\024\004\036\r\024\020\024 \023\ \031\t\030\016)Tj T* (\022\030\024\r\024\021\036\004\036\027\017\036 \r\027\031\021\030\017\002\ \030\033\001\027\024\036)Tj T* (\022\017\001\036\004\027\026\016 \027\036\023\030\024\b\024\007\017\n\024\ \f\021\034)Tj T* (\027\026\020\027\024\036\027\017\036 \035\026\023\026\030\024\021\024\n\027\ \024\005 \030\026\027\t)Tj T* (\220\r\036\027\021\030\026\006\017\016)Tj 0 -1.2 TD (\023\026\030\026\f\021\024\n\026\035\034\027\t\036 \024\f\035\024\032\027\ \036\027\017\016)Tj 0 -1.2 TD (\023\027\036\r\n\024\027\017\016)Tj 27.543 8.401 Td (45)Tj /Span<>> BDC ( )Tj EMC (\(90%\))Tj 0.5 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 1.116 -1.2 Td (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 1.116 -1.2 Td (0)Tj 0 -1.2 TD (0)Tj 0 -1.2 TD (0)Tj 5.471 8.4 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 1.616 -1.2 Td (0)Tj -1.116 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj T* (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 1.116 -1.2 Td (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 7.65 8.4 Td (43)Tj /Span<>> BDC ( )Tj EMC (\(86%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 1.116 -1.2 Td (0)Tj -1.116 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 1.116 -1.2 Td (0)Tj T* (0)Tj 7.026 9.6 Td (0,42)Tj /T1_3 1 Tf -52.484 -11.035 Td (\020\235\202\r\217\003\001 \002\217\f\002\202\b\r\b\t\005 \212\002)Tj /Span<>> BDC ( )Tj EMC (Clavien-Dindo)Tj /T1_1 1 Tf 1.063 -1.2 Td (\027\036\021 \024\f\035\024\032\027\036\027\017\005)Tj T* (I \f\021\036\023\036\027\034)Tj T* (II \f\021\036\023\036\027\034)Tj T* (IIIa \f\021\036\023\036\027\034)Tj T* (IIIb \f\021\036\023\036\027\034)Tj T* (IVa \f\021\036\023\036\027\034)Tj 28.043 6.001 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj -0.5 -1.2 Td (22)Tj /Span<>> BDC ( )Tj EMC (\(44%\))Tj 0 -1.2 TD (16)Tj /Span<>> BDC ( )Tj EMC (\(32%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 0 -1.2 TD (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 0 -1.2 TD (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 7.087 6 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj -0.5 -1.2 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(26%\))Tj 0 -1.2 TD (21)Tj /Span<>> BDC ( )Tj EMC (\(42%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 0 -1.2 TD (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 0.25 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 8.15 6 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj -0.5 -1.2 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(34%\))Tj 0 -1.2 TD (16)Tj /Span<>> BDC ( )Tj EMC (\(32%\))Tj 0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 0 -1.2 TD (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 0.25 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.142 7.2 Td (0,64)Tj /T1_2 1 Tf 7 0 0 7 42.5197 285.5829 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC (\227 \n\032\022\023\027\032\022\235 \250)Tj 4.081 0 0 4.081 128.4152 287.9139 Tm (2)Tj 7 0 0 7 130.4557 285.5829 Tm ( \004\022\032\024\031\025\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.9144 56.0378 Tm (87)Tj ET endstream endobj 1100 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.02 Tw 10 0 0 10 70.8661 201.1759 Tm [(\022\004\b\b\t\r )0.6(\212\002\217\f\r\002\212\r\006\004\204\t\002\b\b\013\r )0.6(\002\217\f\002\202\b\r\b\t\235 )0.5(\212\006\002\214\r\202)]TJ 0 Tw (-)Tj 0 -1.218 TD (\b\002\217\003\b\002\005 \006\004\b\013)Tj /T1_1 1 Tf 0.463 Tw T* [(\200 )0.5(\006\036\035\024\n, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 5.812 0 Td [(\030\026\027\027\036\n )0.6(\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n )0.5(\023\036\030\017\024\007\036 )]TJ 0.096 Tw -5.812 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \017\f\023\024\035\034\024\r\026\027\017\016 \027\ \024\r\024\005 \023\035\026\f\021\017\022\017 \004\026\f\021\024\021\026\ \024\f)Tj 0 Tw (-)Tj 0.055 Tw 0 -1.218 TD (\035\024\032\027\036\027\017\005 \f\024\f\021\026\r\017\035\026 24% \(12\ /50\), \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\f\021\024\020\024 )Tj 0.043 Tw 0 -1.218 TD (\031\001\017\r\026\027\017\016 \030\026\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 32% \(16/50\), \026)Tj /Span<>> BDC ( )Tj EMC (\r \020\030\031\023\023\036 \023\030\017\n\036\027\036)Tj 0 Tw (-)Tj 0.034 Tw 0 -1.218 TD (\027\017\016 \f\036\021\004\026\021\024\020\024 \220\027\007\024\023\030\ \024\021\036\026)Tj /Span<>> BDC ( )Tj EMC (\227 28% \(14/50\), \023\024\035\031\004\036\027)Tj 0 Tw (-)Tj 0.164 Tw 0 -1.218 TD (\027\t\036 \030\026\035\017\004\017\016 \027\036 \017\n\036\035\017 \f\021\ \026\021\017\f\021\017\004\036\f\022\024\005 \027\026\004\017\n\024\f\021\ \017 )Tj 0 Tw 0 -1.218 TD (\()Tj /T1_2 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,67\).)Tj 0.03 Tc 0.401 Tw 0 -1.218 TD (\200 \030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\ \024\027\027\024\n \023\036\030\017\024\007\036 \024\f\035\024\032)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.109 Tw 0 -1.218 TD (\027\036\027\017\016 \f\024 \f\021\024\030\024\027\t \023\030\024\n\036\032\ \027\024\f\021\027\024\005 \030\026\027\t \r)Tj /Span<>> BDC ( )Tj EMC [(\020\030\031\023\023\036)30( )]TJ 0.113 Tw 23.244 12.178 Td (\027\024\r\024\005 \023\035\026\f\021\017\022\017 \030\026\r\017\035\017\ \f\034 \031)Tj /Span<>> BDC ( )Tj EMC [(16% )0.5(\(8/50\) \023\026\006\017\036\027)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc -0.037 Tw 0 -1.218 TD (\021\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\030\024\f\021\024\020\024 \031\001\017\r\026\ \027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \031)Tj /Span<>> BDC ( )Tj EMC [(32% \(16/50\),)30( )]TJ 0.006 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \023\035\026\f\021\017\022\017 \f\036\021\004\026\ \021\t\n \220\027\007\024\023\030\024\021\036\024\n)Tj /Span<>> BDC ( )Tj EMC [(\227 24%)30( )]TJ 0.146 Tw 0 -1.218 TD (\(12/50\), \()Tj /T1_2 1 Tf 0 Tc 0 Tw (\032)Tj /T1_1 1 Tf 0.03 Tc 0.146 Tw /Span<>> BDC 4.925 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,17\). \213\f\035\017 \007\036\021\026\035\017\017\030\024\r\026\021\034\ \030\026\027\027\017\036)30( )]TJ 0.148 Tw -4.925 -1.218 Td [(\024\f\035\024\032\027\036\027\017\016, )0.5(\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 9.346 0 Td [(\023\030\017\n\036\027\036\027\017\017 )0.5(\027\024\r\024\020\024 )0.5(\f\023\024\f\024\002\026)30( )]TJ -0.003 Tw -9.346 -1.218 Td (\023\035\026\f\021\017\022\017 \027\036\f\022\024\035\034\022\024 \030\036\ \032\036 \r\024\027\017\022\026\035\017 \f\036\030\024\n\t \017)Tj /Span<>> BDC ( )Tj EMC 20.724 0 Td (\027\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.268 Tw -20.724 -1.218 Td (\020\027\024\036\027\017\036 \030\026\027\t. \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 \032\036 \r\030\036\n\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\017)30( )]TJ 0.023 Tw 0 -1.218 TD (\027\024\r\024\005 \023\035\026\f\021\017\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\b \027\026\002\035\033\007\036\027\017\016\b \030\026\r\017\035\ \f\016 \027\036)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.06 Tw 0 -1.218 TD (\022\030\024 \022\030\026\036\r \035\024\f\022\031\021\026 \(\r \024\007\ \027\024\n \017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\017\b \027\026\002\035\033\007\036\027\017\005)30( )]TJ 0.153 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC [(\030\026\f\b\024\032\007\036\027\017\036\n \022\030\026\036\r \023\024\f\ \035\036\024\023\036\030\026\006\017\024\027\027\024\005 \030\026\027\t)30( )]TJ 0 Tw 0 -1.218 TD (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \217\240\212\020\t \200\020\032\020\n\023\027\032\022\024\023\022\n\020\ \033\020\006\022\027\025\023\031\021 \b\032\r\033\033 \024\032\020\021\025\ \027\025\022\t \033\031)Tj /Span<>> BDC ( )Tj EMC (\032\027\016\r\f\017\023\020\023\020\026 \004\216\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.324 0 Td [( G)-5.7(e)-7(n)-2.4(e)-6(r)3.4(a)-4.5(l c)-2.5(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.5(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.2(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-6.2(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.4(u)-2.3(p)1.9(s a)-9.2(c)2.3(c)2.8(o)-3(r)-3(d)-3(i)3.9(n)-0.6(g t)-3(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e r)-2(e)-22(s)6.8(u)-1.6(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.6(h)-2.4(e P)22.6(H)14.9(I)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 715.181 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.9351 715.181 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 715.181 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 684.5118 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.9351 684.5118 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 684.5118 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 663.6925 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 663.4425 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 663.4425 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 663.4425 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.9351 663.4425 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 663.4425 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 642.6233 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 642.3733 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 642.3733 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 642.3733 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.9351 642.3733 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 642.3733 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 621.5541 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 621.3041 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 621.3041 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 621.3041 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 621.3041 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 621.3041 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 610.0849 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 609.8349 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 609.8349 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 609.8349 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 609.8349 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 609.8349 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 598.6157 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 598.3657 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 598.3657 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 598.3657 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 598.3657 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 598.3657 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 587.1464 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 586.8964 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 586.8964 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 586.8964 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 586.8964 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 586.8964 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 575.6772 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 575.4272 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 246.8642 575.4272 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 323.3996 575.4272 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 399.9351 575.4272 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 476.4705 575.4272 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 524.6594 535.408 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 535.158 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 535.158 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 535.158 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.9351 535.158 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 535.158 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 504.7388 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 504.4888 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 246.8642 504.4888 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 323.3996 504.4888 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 399.9351 504.4888 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 476.4705 504.4888 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 524.6594 464.4696 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 464.2196 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 246.8642 464.2196 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 323.3996 464.2196 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 399.9351 464.2196 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 476.4705 464.2196 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 524.6594 405.0004 cm 0 0 m 0 58.969 l S Q q 1 0 0 1 70.8661 404.7504 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 246.8642 404.7504 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 323.3996 404.7504 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 399.9351 404.7504 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 476.4705 404.7504 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 393.5311 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 393.2811 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 393.2811 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 393.2811 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.9351 393.2811 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 476.4705 393.2811 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_0 1 Tf 8 0 0 8 137.5944 696.9465 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.025 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_3 1 Tf 2.091 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.813 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_3 1 Tf 2.754 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.736 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_3 1 Tf 1.724 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_3 1 Tf 6.661 1.2 Td (\t)Tj /T1_0 1 Tf (-\213\b\004\201\r\b\t\r)Tj -50.866 -2.634 Td (\225\t\006\210\006\n\t\201\r\217\220\t\005 \220\f\t\006\r\b\217)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.256 0.001 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(10;14\))Tj 9.567 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(10;15\))Tj 9.567 0 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(10;13\))Tj 9.095 1.2 Td (0,96)Tj /T1_0 1 Tf -52.484 -2.635 Td (\021\002\f\t\201\r\217\003\002 \t\217\217\f\r\240\002\004\b\b\013\216 \ \f\t\214\226\002\210\213\f\002)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.256 0.001 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(12;16\))Tj 9.567 0 Td (15)Tj /Span<>> BDC ( )Tj EMC (\(12;16\))Tj 9.567 0 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(13;16\))Tj 9.095 1.2 Td (0,05)Tj /T1_0 1 Tf -52.484 -2.635 Td (\021\002\f\t\201\r\217\003\002 \212\002\006\004\202\r\b\b\013\216 \f\t\214\ \226\002\210\213\f\002)Tj /T1_2 1 Tf T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.663 0.001 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;1,1\))Tj 9.909 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;0\))Tj 9.567 0 Td (0)Tj /Span<>> BDC ( )Tj EMC (\(0;2\))Tj 8.345 1.2 Td (0,88)Tj /T1_0 1 Tf -52.484 -2.635 Td (\017\212\210\216\002\f\r\013\r \240\r\212\002\213\t\003\013)Tj /T1_1 1 Tf 24.782 0.001 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.567 0 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.567 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 8.569 0 Td (0,79)Tj /T1_0 1 Tf -52.484 -1.435 Td (\231\220\217\003\004\214\210\006\004\f\001\b\004\235 \r\b\002\213\b\004\ \235 \t\b\004\213\t\235)Tj /T1_1 1 Tf 25.032 0.001 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.567 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 9.567 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 8.319 0 Td (0,55)Tj /T1_0 1 Tf -52.484 -1.435 Td (\035\t\214\226\002\004\217\220\210\f\235\006\b\004\235 \t\b\004\213\t\235\ )Tj /T1_1 1 Tf 24.782 0.001 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 9.567 0 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.317 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 8.819 0 Td (0,31)Tj /T1_0 1 Tf -52.484 -1.435 Td (\200\r\006\t\b\r\006\004\f\001\b\013\005 \006\002\217\003)Tj /T1_1 1 Tf 24.782 0.001 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 9.567 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 9.567 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj 8.569 0 Td (0,61)Tj /T1_0 1 Tf -52.484 -1.435 Td (\037\r\f\002\217\003\b\002\217\003\001 \214\r\213\002\006\r\220\003\004\f\ \001\b\002\005 \226\004\217\204\t\t)Tj /T1_1 1 Tf 1.063 -1.2 Td (\n\t\001\036\004\027\t\005 \f\035\024\005 \(G1\))Tj T* (\017\027\021\030\026\n\036\024\030\036\022\021\026\035\034\027\024 \(G2\ \))Tj T* (\n\036\024\030\036\022\021\026\035\034\027\026\016 \235\026\f\006\017\016\ \(G3\))Tj 23.719 2.401 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj -0.25 -1.2 Td (31)Tj /Span<>> BDC ( )Tj EMC (\(62%\))Tj T* (10)Tj /Span<>> BDC ( )Tj EMC (\(20%\))Tj 9.567 2.4 Td (17)Tj /Span<>> BDC ( )Tj EMC (\(34%\))Tj 0 -1.2 TD (29)Tj /Span<>> BDC ( )Tj EMC (\(58%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 9.317 2.4 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj -0.25 -1.2 Td (37)Tj /Span<>> BDC ( )Tj EMC (\(74%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 8.569 3.6 Td (0,04)Tj /T1_0 1 Tf -52.484 -5.035 Td (\027\t\217\003\002\f\002\n\t\201\r\217\220\002\r \217\003\006\002\r\b\t\r\ )Tj /T1_1 1 Tf 1.063 -1.2 Td (\026\007\036\027\024\022\026\030\006\017\027\024\n\026)Tj 0 -1.2 TD (\026\007\036\027\024\022\026\030\006\017\027\024\n\026 \f\035\017\017\f\ \021\026\016)Tj 23.219 1.201 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1.866 -1.2 Td (0)Tj 7.701 1.2 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1.866 -1.2 Td (0)Tj 7.951 1.2 Td (48)Tj /Span<>> BDC ( )Tj EMC (\(96%\))Tj 0.5 -1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 8.319 2.4 Td (0,13)Tj /T1_0 1 Tf -52.484 -3.835 Td (\031\t\226\226\r\006\r\b\204\t\006\002\220\004 \002\212\210\216\002\f\t\ )Tj /T1_1 1 Tf 1.063 -1.2 Td (G1)Tj 0 -1.2 TD (G2)Tj 0 -1.2 TD (G3)Tj 23.469 2.401 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 0 -1.2 TD (31)Tj /Span<>> BDC ( )Tj EMC (\(62%\))Tj 0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj 9.317 2.4 Td (14)Tj /Span<>> BDC ( )Tj EMC (\(28%\))Tj T* (30)Tj /Span<>> BDC ( )Tj EMC (\(60%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(12%\))Tj 9.317 2.4 Td (12)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj T* (34)Tj /Span<>> BDC ( )Tj EMC (\(68%\))Tj 0.5 -1.2 Td (4)Tj /Span<>> BDC ( )Tj EMC (\(8%\))Tj 8.319 3.6 Td (0,86)Tj /T1_0 1 Tf -52.484 -5.035 Td (\026\f\t\235\b\t\r \b\r\002\004\240\233\211\004\b\003\b\002\n\002 \f\r\201\ \r\b\t\235)Tj /T1_1 1 Tf 1.063 -1.2 Td (TRG 0 \(\023\024\035\027\t\005 \024\021\r\036\021\))Tj T* (TRG 1 \(\023\024\004\021\017 \023\024\035\027\t\005 \024\021\r\036\021\)\ )Tj T* (TRG 2 \(\004\026\f\021\017\004\027\t\005 \024\021\r\036\021\))Tj T* (TRG 3 \(\027\036\021 \024\021\r\036\021\026\))Tj T* (\027\036 \023\030\024\r\024\007\017\035\024\f\034)Tj 23.969 4.801 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(3%\))Tj -0.25 -1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(14%\))Tj -0.25 -1.2 Td (30)Tj /Span<>> BDC ( )Tj EMC (\(60%\))Tj 0.25 -1.2 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(18%\))Tj 0.25 -1.2 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(6%\))Tj 9.567 4.8 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj -0.25 -1.2 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(16%\))Tj -0.25 -1.2 Td (25)Tj /Span<>> BDC ( )Tj EMC (\(50%\))Tj T* (14)Tj /Span<>> BDC ( )Tj EMC (\(28%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 9.567 4.8 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj -0.5 -1.2 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(22%\))Tj 0 -1.2 TD (24)Tj /Span<>> BDC ( )Tj EMC (\(48%\))Tj 0 -1.2 TD (12)Tj /Span<>> BDC ( )Tj EMC (\(24%\))Tj 0.5 -1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(2%\))Tj 8.319 6 Td (0,77)Tj /T1_0 1 Tf -52.484 -7.435 Td (\200\r\006\226\002\006\004\204\t\235 \002\212\210\216\002\f\t)Tj /T1_1 1 Tf 25.032 0.001 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(4%\))Tj 9.317 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 9.567 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(10%\))Tj 8.569 0 Td (0,46)Tj /T1_2 1 Tf 7 0 0 7 70.8661 381.7966 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020 \030\f\t \n\031\f\022\007\027\024\023\021\027\025\025\ \013\200 \033\031\n\020\016\020)49.3(\023\027\f\027\235; \n\032\022\023\027\032\022\235 \250)]TJ 4.081 0 0 4.081 344.0359 384.1276 Tm (2)Tj 7 0 0 7 346.0763 381.7966 Tm [( \004\022\032\024\031\025\020 \030\f\t \n\020\007\027\024\023\021\027\025\ \025\013\200 \033\031\n\020\016\020)49(\023\027\f\027\235)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 9 0 0 9 70.8661 362.4926 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \004\031\n\020\016\020\023\027\f\022 \033\032\031\030\031\f\255\022\023\ \027\f\017\025\031\024\023\022 \031\033\027\032\020\023\022\021\025\031\b\ \031 \021\026\027\213\020\023\027\f\017\024\023\021\020 \022)Tj /Span<>> BDC ( )Tj EMC (\031\240\236\027\026\020 \n\032\031\021\031\033\031\023\027\032\022 \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 \024\032\020\021\025\027\025\022\t)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.334 0 Td [( I)2.2(n)-4.8(d)-3(i)-1.7(c)3.2(a)-9.2(t)-3(o)-3(r)-14.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e d)0.8(u)1.6(r)3.3(a)-9.2(t)-29.1(i)-1.3(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)6.7(u)1.6(r)-2(g)-6.8(e)-6(r)-43.7(y a)-5.1(n)-4.8(d t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(v)3.3(o)-5.3(lu)0.6(m)-5.3(e o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(b)-3.3(l)-1.6(o)-12(o)-12(d l)-1.6(o)-1(s)-10.5(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-3.9(m)-1(p)-6.3(a)-4.2(r)-39(i)6.6(s)0.5(o)-4(n g)-1.5(r)-2(o)-3.3(u)-2.3(p)1.8(s)]TJ ET /GS2 gs q 1 0 0 1 70.8661 347.1907 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 347.1907 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 347.1907 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.935 347.1907 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 347.1907 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 316.7715 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 316.5215 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 316.5215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 316.5215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.935 316.5215 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 316.5215 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 295.7022 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 295.4522 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 246.8642 295.4522 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 323.3996 295.4522 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 399.935 295.4522 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 476.4705 295.4522 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 524.6594 265.033 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 70.8661 264.783 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 71.1161 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 246.8642 264.783 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 246.8642 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 323.3996 264.783 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 399.935 264.783 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 476.4705 264.783 cm 0 0 m 48.439 0 l S Q q 1 0 0 1 476.4705 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 243.9638 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 243.7138 cm 0 0 m 175.998 0 l S Q q 1 0 0 1 246.8642 243.7138 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 323.3996 243.7138 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 399.935 243.7138 cm 0 0 m 76.535 0 l S Q q 1 0 0 1 476.4705 243.7138 cm 0 0 m 48.439 0 l S Q BT /GS1 gs /T1_0 1 Tf 8 0 0 8 137.5944 328.9561 Tm (\200\r\006\r\214\r\b\b\004\235)Tj 15.025 0.6 Td (\025\002\004\235 \212\f\004\217\003\t\220\004)Tj /T1_3 1 Tf 2.091 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.813 1.2 Td (\200\006\002\217\003\002\r \210\230\t\004\b\t\r)Tj /T1_3 1 Tf 2.754 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj 6.736 1.8 Td (\200\f\004\217\003\t\220\004 \217\r\003\201\004\003\013\214 )Tj 1.107 -1.2 Td (\234\b\240\002\212\006\002\003\r\213\002\214)Tj /T1_3 1 Tf 1.724 -1.2 Td (n)Tj /T1_0 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50)Tj /T1_3 1 Tf 6.51 1.2 Td (\t)Tj /T1_0 1 Tf (-\213\b\004\201\r\b\t\r)Tj /T1_3 1 Tf 4.664 0 0 4.664 519.0408 331.6201 Tm (\001)Tj /T1_0 1 Tf 8 0 0 8 73.9508 307.8869 Tm (\017\206\227\r\r \006\r\214\235 \002\212\r\006\004\204\t\t, )Tj /T1_2 1 Tf (\026\022\025\r\023)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 23.506 0.001 Td (180)Tj /Span<>> BDC ( )Tj EMC (\(180;205\))Tj 9.567 0 Td (170)Tj /Span<>> BDC ( )Tj EMC (\(140;210\))Tj 9.567 0 Td (180)Tj /Span<>> BDC ( )Tj EMC (\(155;200\))Tj 9.845 1.2 Td (0,05)Tj /T1_0 1 Tf -52.484 -2.635 Td (\200\006\002\240\002\f\202\t\003\r\f\001\b\002\217\003\001 \234\003\004\212\ \004 \212\f\004\217\003\t\220\t )Tj T* (\212\006\002\214\r\202\b\002\217\003\b\002\005 \006\004\b\013, )Tj /T1_2 1 Tf (\026\022\025\r\023)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 24.256 0.001 Td (50)Tj /Span<>> BDC ( )Tj EMC (\(45;55\))Tj 9.567 0 Td (20)Tj /Span<>> BDC ( )Tj EMC (\(20;25\))Tj 9.567 0 Td (35)Tj /Span<>> BDC ( )Tj EMC (\(30;40\))Tj 8.228 2.4 Td (<)Tj /Span<>> BDC ( )Tj EMC (0,0001)Tj /T1_0 1 Tf -51.618 -3.835 Td (\017\206\233\r\214 \220\006\002\002\212\002\003\r\006\t, )Tj /T1_2 1 Tf (\026\f)Tj T* (Me \(Q1; Q3\))Tj /T1_1 1 Tf 23.506 0.001 Td (100)Tj /Span<>> BDC ( )Tj EMC (\(100;200\))Tj 9.567 0 Td (150)Tj /Span<>> BDC ( )Tj EMC (\(100;210\))Tj 9.567 0 Td (150)Tj /Span<>> BDC ( )Tj EMC (\(100;200\))Tj 9.845 1.2 Td (0,30)Tj /T1_2 1 Tf 7 0 0 7 70.8661 232.2292 Tm (\004\032\022\026\027\007\020\025\022\027: \032)Tj /Span<>> BDC ( )Tj EMC [(\227 \n\032\022\023\027\032\022\235 \202\032\020\024\n\027\f\020\231\210\ )30.3(\031\f\f\022\024\020)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (86)Tj ET endstream endobj 972 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 973 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 974 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 975 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 976 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1157 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.668 Tw 10 0 0 10 42.5197 724.8299 Tm [(\f\r\016\022\024\005 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 5.608 0 Td [(\022\030\036\f\021\006\024\r\024-\022\024\023\004\017\022\024\r\t\n )0.6(\f\024\004\035\036\027\036\027\017\036\n\), )]TJ 0.113 Tw -5.608 -1.218 Td (\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\005 \021\030\036\021\017 \022\030\036\f\021\006\024\ \r\024-\002\031\020\024\030\027\024\005 \f\r\016\022\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \024\002)Tj 0 Tw (-)Tj 0.159 Tw 0 -1.218 TD (\035\026\f\021\017 \f\036\007\026\035\017\013\027\024\020\024 \002\031\020\ \030\026 \(\022\024\027\036\004\027\t\005 \031\004\026\f\021\024\022 \022\ \030\036\f\021)Tj 0 Tw (-)Tj 0.244 Tw T* (\006\024\r\024-\002\031\020\024\030\027\024\005 \f\r\016\022\017\). \212\ \024\023\024\035\027\017\021\036\035\034\027\024 \f\036\021\022\031 \235\ \017\022)Tj 0 Tw (-)Tj 0.089 Tw T* (\f\017\030\024\r\026\035\017 \022)Tj /Span<>> BDC ( )Tj EMC (\n\016\020\022\017\n \021\022\026\027\016\n \n\036\032\007\031 \024\023\017\ \f\026\027\027\t\n\017 \r\t\001\036 )Tj 0 Tw T* (\001\r\026\n\017.)Tj /T1_2 1 Tf 0 -2.436 TD (\017\204\r\b\t\004\r\214\013\r \212\004\006\004\214\r\003\006\013)Tj /T1_3 1 Tf 0 -1.218 TD (\002\025\023\032\020\031\033\027\032\020\006\022\031\025\025\013\027:)Tj /T1_1 1 Tf 0.898 Tw ( \024\002\013\026\016 \023\030\024\007\024\035\032\017\021\036\035\034\027\ \024\f\021\034 )Tj 0.245 Tw T* (\024\023\036\030\026\006\017\017, \023\030\024\007\024\035\032\017\021\036\ \035\034\027\024\f\021\034 \220\021\026\023\026 \023\035\026\f\021\017\022\ \017 \023\030\024)Tj 0 Tw (-)Tj 1.06 Tw T* (\n\036\032\027\024\f\021\027\024\005 \030\026\027\t, \024\002\255\201\n \ \017\027\021\030\026\024\023\036\030\026\006\017\024\027\027\024\005 )Tj 0 Tw 0 -1.218 TD (\022\030\024\r\024\023\024\021\036\030\017.)Tj /T1_3 1 Tf 0.226 Tw 0 -1.218 TD [(\206\020\025\025\022\235 )0.5(\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\013\235 )0.7(\033\027\032\022\031\030 )0.5(\(\030\031 )0.5(30 )0.5(\024\r\023\031\n\):)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.068 Tw 0 -1.218 TD (\017\027\021\036\027\f\017\r\027\024\f\021\034 \002\024\035\036\r\024\020\ \024 \f\017\027\007\030\024\n\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\004\017\f\035\024\r\024\005 \030\036\005)Tj 0 Tw (-)Tj 0.155 Tw 0 -1.218 TD (\021\017\027\020\024\r\024\005 \001\022\026\035\036 \(NRS\) \027\026)Tj /Span<>> BDC ( )Tj EMC (1, 3, 5, 7-\036 \f\031\021\022\017; \004\026\f\021\024\021\026 )Tj 0.076 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\030\031\022\021\031\030\026 \024\f\035\024\032\027\036\027\017\005\ \f\024 \f\021\024\030\024\027\t \023\030\024\n\036\032\027\024\f\021\027\ \024\005 )Tj 0.097 Tw 0 -1.218 TD (\030\026\027\t \(\f\036\030\024\n\026, \020\036\n\026\021\024\n\026, \027\ \026\020\027\024\036\027\017\036, \027\036\022\030\024 \035\024\f\022\031\ \021\026\) )Tj 0.104 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\b \024\f\035\024\032\027\036\027\017\005; \021\016\032\036\ \f\021\034 \024\f\035\024\032\027\036\027\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\035\026\f)Tj 0 Tw (-)Tj 1.346 Tw 0 -1.218 TD [(\f\017\235\017\022\026\006\017\017 Cl)-16(av)-16(ien\226Dind)-15.9(o; \023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 )]TJ 0 Tw 0 -1.218 TD (\020\024\f\023\017\021\026\035\017\026\006\017\017.)Tj /T1_3 1 Tf 0.245 Tw T* (\217\023\030\020\f\233\025\025\013\235 \033\027\032\022\031\030 \(\026\027\ \030\022\020\025\020 14 \026\027\024\t\006\027\021\):)Tj /T1_1 1 Tf ( \004\026\f\021\024)Tj 0 Tw (-)Tj 0.105 Tw 0 -1.218 TD [(\021\026 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 2.036 0 Td [(\f\021\030\031\022\021\031\030\026 )0.5(\023\024\007\027\017\b )0.5(\024\f\035\024\032\027\036\027\017\005 )0.6(\023\030\024\n\036\032\027\024\f\021\027\024\005 )]TJ 0.07 Tw -2.036 -1.218 Td (\030\026\027\t \(\f\r\017\013\017, \026\002\f\006\036\f\f\t, \023\030\024\ \n\036\032\027\024\f\021\027\t\036 \020\030\t\032\017, \b\030\024)Tj 0 Tw (-)Tj 0.047 Tw 0 -1.218 TD (\027\017\004\036\f\022\017\005 \002\024\035\036\r\024\005 \f\017\027\007\ \030\024\n\); \024\006\036\027\022\026 \022\026\004\036\f\021\r\026 \032\ \017\027\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \024\023\030\024\f\027\017\022\024\r EQ-5D-3L\ \017)Tj /Span<>> BDC ( )Tj EMC [(EQ-V)37.2(A)35(S.)]TJ /T1_4 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf 0.241 Tw 0 -1.218 TD (\215\030\017 \024\023\030\036\007\036\035\036\027\017\017 \024\002\255\036\ \n\026 \r\t\002\024\030\022\017 \017\f\023\024\035\034\024\r\026\035\017\ \f\034 )Tj 0.349 Tw 0 -1.218 TD (\017\n\036\033\013\017\036\f\016 \007\026\027\027\t\036 \023\024\023\031\ \035\016\006\017\024\027\027\t\b \017\f\f\035\036\007\024\r\026\027\017\005\ , )Tj 0.242 Tw 0 -1.218 TD (\017\031\004\026\033\013\017\b \004\026\f\021\024\021\031 \030\026\r\017\ \021\017\016 \023\030\024\n\036\032\027\024\f\021\027\t\b \020\030\t\032\ )Tj 0.177 Tw 0 -1.218 TD ([3,14,15], \f\024\020\035\026\f\027\024 \022\024\021\024\030\t\n \220\021\ \024\021 \023\024\022\026\026\021\036\035\034 \022\024\035\036\002)Tj 0 Tw (-)Tj -0.071 Tw T* (\035\036\021\f\016 \024\021 3,3% \007\024)Tj /Span<>> BDC ( )Tj EMC (67%, \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\036\007\027\036\n 35%. \215\030\036\007\023\024\035\026\020\026\036\ \n\024\036 )Tj 0.393 Tw T* (\f\027\017\032\036\027\017\036 \004\026\f\021\024\021\t \r\024\027\017\022\ \027\024\r\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\027\024\005\ )Tj 0.345 Tw T* (\020\030\t\032\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\n\036\027\036\027\017\017 \027\024\r\024\020\024 \f\023\024\ \f\024\002\026 \023\035\026\f\021\017\022\017 )Tj -0.013 Tw T* (\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\020\024 \007\027\026 \f\024\f\021\026\r\035\016\036\021\ 10%.)Tj 0.813 Tw 0 -1.218 TD (\215\030\017 \030\026\f\004\036\021\036 \024\002\255\036\n\026 \r\t\002\024\ \030\022\017 \017\f\023\024\035\034\024\r\026\035\026\f\034 )Tj 0 Tw 0 -1.218 TD (\235\024\030\n\031\035\026 )Tj ET 0 0 0 0 k /GS0 gs 118.439 262.066 65.083 22.225 re f /PlacedPDF /MC0 BDC q 118.439 262.066 65.083 22.225 re W n 0 0 0 1 k q 1 0 0 1 120.2536 269.4193 cm 0 0 m -0.094 0 -0.175 0.025 -0.242 0.076 c -0.309 0.126 -0.343 0.195 -0.343 0.282 c -0.343 0.37 -0.215 0.917 0.04 1.925 c 0.296 2.933 0.43 3.481 0.444 3.568 c 0.45 3.602 0.454 3.679 0.454 3.8 c 0.454 4.062 0.373 4.193 0.212 4.193 c 0.057 4.193 -0.084 4.069 -0.212 3.82 c -0.286 3.679 -0.356 3.468 -0.423 3.185 c -0.464 3.051 -0.484 2.98 -0.484 2.974 c -0.497 2.933 -0.561 2.913 -0.675 2.913 c -0.816 2.913 l -0.857 2.953 -0.877 2.984 -0.877 3.004 c -0.877 3.031 -0.86 3.101 -0.827 3.216 c -0.625 4.008 -0.316 4.452 0.101 4.546 c 0.155 4.56 0.212 4.566 0.272 4.566 c 0.669 4.566 0.954 4.415 1.129 4.113 c 1.203 3.985 1.24 3.891 1.24 3.83 c 1.24 3.817 1.243 3.81 1.25 3.81 c 1.361 3.921 l 1.777 4.352 2.244 4.566 2.762 4.566 c 3.132 4.566 3.427 4.476 3.649 4.294 c 3.871 4.113 3.982 3.847 3.982 3.498 c 3.982 3.343 3.972 3.216 3.951 3.115 c 3.884 2.732 3.699 2.144 3.397 1.351 c 3.276 1.028 3.216 0.79 3.216 0.635 c 3.216 0.46 3.273 0.373 3.387 0.373 c 3.615 0.373 3.812 0.494 3.977 0.736 c 4.141 0.978 4.267 1.257 4.355 1.572 c 4.368 1.626 4.435 1.653 4.556 1.653 c 4.691 1.653 4.758 1.63 4.758 1.583 c 4.758 1.536 4.744 1.482 4.717 1.421 c 4.543 0.796 4.227 0.356 3.77 0.101 c 3.649 0.04 3.504 0.01 3.336 0.01 c 3.081 0.01 2.863 0.091 2.681 0.252 c 2.52 0.44 2.439 0.638 2.439 0.847 c 2.439 0.974 2.486 1.163 2.58 1.412 c 2.876 2.197 3.064 2.796 3.145 3.205 c 3.165 3.306 3.175 3.434 3.175 3.588 c 3.175 3.985 3.011 4.183 2.681 4.183 c 2.56 4.183 2.473 4.176 2.419 4.163 c 1.949 4.062 1.549 3.73 1.22 3.165 c 1.149 3.044 l 0.816 1.693 l 0.595 0.813 0.467 0.339 0.433 0.272 c 0.346 0.091 0.202 0 0 0 c f Q q 1 0 0 1 128.6019 273.028 cm 0 0 m 0 0.087 0.047 0.155 0.141 0.202 c 6.562 0.202 l 6.663 0.155 6.713 0.087 6.713 0 c 6.713 -0.074 6.666 -0.138 6.572 -0.191 c 3.367 -0.202 l 0.161 -0.202 l 0.054 -0.168 0 -0.101 0 0 c 0 -1.956 m 0 -1.855 0.054 -1.788 0.161 -1.754 c 6.572 -1.754 l 6.579 -1.761 6.594 -1.772 6.618 -1.789 c 6.641 -1.806 6.658 -1.819 6.668 -1.829 c 6.678 -1.84 6.688 -1.856 6.698 -1.88 c 6.708 -1.903 6.713 -1.929 6.713 -1.956 c 6.713 -2.043 6.663 -2.11 6.562 -2.157 c 0.141 -2.157 l 0.047 -2.11 0 -2.043 0 -1.956 c f Q q 1 0 0 1 155.5169 262.6396 cm 0 0 m -0.034 0.013 -0.05 0.037 -0.05 0.071 c -0.05 0.084 0.519 1.26 1.658 3.599 c 2.797 5.937 3.377 7.12 3.397 7.147 c 3.424 7.194 3.518 7.217 3.679 7.217 c 3.834 7.217 3.928 7.194 3.961 7.147 c 3.982 7.12 4.561 5.937 5.7 3.599 c 6.839 1.26 7.409 0.084 7.409 0.071 c 7.409 0.037 7.392 0.013 7.358 0 c h 5.836 0.917 m 5.836 0.937 5.01 2.634 3.357 6.008 c 2.98 5.248 2.564 4.402 2.107 3.468 c 0.867 0.927 l 3.347 0.917 l h f Q q 1 0 0 1 164.1786 268.6049 cm 0 0 m -0.132 0 -0.235 0.042 -0.31 0.127 c -0.385 0.211 -0.423 0.315 -0.423 0.437 c -0.423 0.776 -0.295 1.066 -0.039 1.308 c 0.217 1.55 0.524 1.671 0.881 1.671 c 1.286 1.671 1.621 1.562 1.887 1.343 c 2.152 1.124 2.315 0.839 2.377 0.487 c 2.386 0.402 2.391 0.324 2.391 0.254 c 2.391 -0.019 2.308 -0.275 2.144 -0.515 c 2.012 -0.712 1.747 -0.983 1.347 -1.326 c 1.178 -1.472 0.942 -1.688 0.642 -1.975 c 0.226 -2.369 l 0.762 -2.377 l 1.5 -2.377 1.892 -2.365 1.939 -2.341 c 1.958 -2.336 1.982 -2.287 2.01 -2.194 c 2.029 -2.141 2.061 -1.982 2.108 -1.714 c 2.108 -1.692 l 2.391 -1.692 l 2.391 -1.714 l 2.193 -3.004 l 2.193 -3.025 l -0.423 -3.025 l -0.423 -2.891 l -0.423 -2.797 -0.418 -2.743 -0.409 -2.729 c -0.404 -2.719 -0.207 -2.496 0.183 -2.059 c 0.696 -1.49 1.025 -1.114 1.17 -0.931 c 1.486 -0.503 1.643 -0.11 1.643 0.246 c 1.643 0.557 1.562 0.816 1.4 1.026 c 1.238 1.235 1.011 1.34 0.719 1.34 c 0.446 1.34 0.226 1.217 0.057 0.973 c 0.047 0.954 0.033 0.928 0.014 0.895 c 0 0.872 -0.007 0.858 -0.007 0.853 c -0.007 0.848 0.004 0.846 0.028 0.846 c 0.146 0.846 0.241 0.804 0.314 0.719 c 0.386 0.634 0.423 0.536 0.423 0.423 c 0.423 0.305 0.384 0.206 0.307 0.123 c 0.229 0.041 0.127 0 0 0 c f Q 139.745 272.719 42.84 -0.42 re f q 1 0 0 1 141.2766 275.9251 cm 0 0 m 0 -0.282 0.091 -0.423 0.272 -0.423 c 0.319 -0.423 0.36 -0.42 0.393 -0.413 c 0.729 -0.353 1.035 -0.084 1.31 0.393 c 1.378 0.501 1.438 0.625 1.492 0.766 c 1.505 0.806 1.522 0.832 1.542 0.842 c 1.562 0.852 1.613 0.857 1.693 0.857 c 1.828 0.857 1.895 0.83 1.895 0.776 c 1.895 0.763 1.882 0.722 1.855 0.655 c 1.781 0.44 1.662 0.223 1.497 0.005 c 1.332 -0.213 1.166 -0.386 0.998 -0.514 c 0.749 -0.702 0.484 -0.796 0.202 -0.796 c -0.04 -0.796 -0.247 -0.734 -0.418 -0.61 c -0.59 -0.486 -0.706 -0.323 -0.766 -0.121 c -0.78 -0.067 -0.786 0.024 -0.786 0.151 c -0.786 0.333 l -0.433 1.744 l -0.198 2.691 -0.077 3.168 -0.071 3.175 c -0.071 3.189 -0.242 3.195 -0.585 3.195 c -1.099 3.195 l -1.139 3.236 -1.161 3.263 -1.164 3.276 c -1.168 3.289 -1.159 3.347 -1.139 3.447 c -1.112 3.541 -1.095 3.592 -1.089 3.599 c -1.075 3.632 -1.043 3.651 -0.993 3.654 c -0.942 3.657 -0.773 3.659 -0.484 3.659 c 0.05 3.659 l 0.242 4.465 l 0.383 5.01 0.464 5.302 0.484 5.342 c 0.564 5.531 0.719 5.625 0.948 5.625 c 1.035 5.618 1.11 5.588 1.174 5.534 c 1.238 5.48 1.27 5.41 1.27 5.322 c 1.27 5.242 1.206 4.956 1.079 4.465 c 1.052 4.351 1.02 4.225 0.983 4.087 c 0.946 3.95 0.917 3.847 0.897 3.78 c 0.877 3.679 l 0.877 3.666 1.045 3.659 1.381 3.659 c 1.895 3.659 l 1.935 3.619 1.957 3.59 1.961 3.573 c 1.964 3.557 1.956 3.494 1.935 3.387 c 1.915 3.306 1.882 3.242 1.835 3.195 c 0.756 3.195 l 0.393 1.734 l 0.144 0.732 0.017 0.205 0.01 0.151 c 0.003 0.118 0 0.067 0 0 c f Q q 1 0 0 1 156.2542 275.5319 cm 0 0 m 0 -0.054 -0.02 -0.101 -0.06 -0.141 c -0.101 -0.181 -0.151 -0.202 -0.212 -0.202 c -0.245 -0.202 -0.319 -0.148 -0.433 -0.04 c -0.548 0.067 -0.864 0.38 -1.381 0.897 c -2.429 1.945 l -3.488 0.887 l -4.2 0.188 -4.566 -0.168 -4.586 -0.181 c -4.613 -0.195 -4.637 -0.202 -4.657 -0.202 c -4.711 -0.202 -4.759 -0.181 -4.803 -0.141 c -4.847 -0.101 -4.869 -0.054 -4.869 0 c -4.869 0.013 -4.862 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1.653 c 3.404 1.653 3.488 1.646 3.568 1.633 c 3.918 1.552 4.197 1.373 4.405 1.094 c 4.613 0.815 4.717 0.46 4.717 0.03 c 4.717 -0.286 4.654 -0.628 4.526 -0.998 c 4.358 -1.441 4.109 -1.83 3.78 -2.162 c 3.451 -2.495 3.091 -2.722 2.701 -2.843 c 2.554 -2.883 2.392 -2.903 2.218 -2.903 c 1.861 -2.903 1.583 -2.765 1.381 -2.49 c 1.331 -2.439 l 1.324 -2.446 1.25 -2.738 1.109 -3.316 c 0.968 -3.894 0.897 -4.187 0.897 -4.193 c 0.897 -4.207 0.899 -4.219 0.902 -4.229 c 0.906 -4.239 0.912 -4.247 0.922 -4.254 c 0.932 -4.26 0.942 -4.266 0.953 -4.269 c 0.963 -4.272 0.976 -4.276 0.993 -4.279 c 1.01 -4.282 1.026 -4.284 1.043 -4.284 c 1.06 -4.284 1.082 -4.286 1.109 -4.289 c 1.136 -4.292 1.159 -4.294 1.179 -4.294 c 1.26 -4.294 l 1.351 -4.294 l 1.603 -4.294 l 1.636 -4.341 1.655 -4.371 1.658 -4.385 c 1.662 -4.398 1.653 -4.459 1.633 -4.566 c 1.613 -4.647 1.593 -4.699 1.572 -4.723 c 1.552 -4.746 1.509 -4.758 1.441 -4.758 c 1.334 -4.758 1.158 -4.754 0.912 -4.748 c 0.667 -4.741 0.484 -4.738 0.363 -4.738 c -0.108 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0.127 c -0.385 0.211 -0.423 0.315 -0.423 0.437 c -0.423 0.776 -0.295 1.066 -0.039 1.308 c 0.217 1.55 0.524 1.671 0.881 1.671 c 1.286 1.671 1.621 1.562 1.887 1.343 c 2.152 1.124 2.315 0.839 2.377 0.487 c 2.386 0.402 2.391 0.324 2.391 0.254 c 2.391 -0.019 2.308 -0.275 2.144 -0.515 c 2.012 -0.712 1.747 -0.983 1.347 -1.326 c 1.178 -1.472 0.942 -1.688 0.642 -1.975 c 0.226 -2.369 l 0.762 -2.377 l 1.5 -2.377 1.892 -2.365 1.939 -2.341 c 1.958 -2.336 1.982 -2.287 2.01 -2.194 c 2.029 -2.141 2.061 -1.982 2.108 -1.714 c 2.108 -1.692 l 2.391 -1.692 l 2.391 -1.714 l 2.193 -3.004 l 2.193 -3.025 l -0.423 -3.025 l -0.423 -2.891 l -0.423 -2.797 -0.418 -2.743 -0.409 -2.729 c -0.404 -2.719 -0.207 -2.496 0.183 -2.059 c 0.696 -1.49 1.025 -1.114 1.17 -0.931 c 1.486 -0.503 1.643 -0.11 1.643 0.246 c 1.643 0.557 1.562 0.816 1.4 1.026 c 1.238 1.235 1.011 1.34 0.719 1.34 c 0.446 1.34 0.226 1.217 0.057 0.973 c 0.047 0.954 0.033 0.928 0.014 0.895 c 0 0.872 -0.007 0.858 -0.007 0.853 c -0.007 0.848 0.004 0.846 0.028 0.846 c 0.146 0.846 0.241 0.804 0.314 0.719 c 0.386 0.634 0.423 0.536 0.423 0.423 c 0.423 0.305 0.384 0.206 0.307 0.123 c 0.229 0.041 0.127 0 0 0 c f Q EMC Q BT 0 0 0 1 k /GS1 gs /T1_1 1 Tf 10 0 0 10 183.5229 262.0659 Tm ( ,)Tj 0.146 Tw -14.1 -1.218 Td (\030)Tj /Span<>> BDC ( )Tj EMC [(\227 \r\036\035\017\004\017\027\026 )0.5(\023\024\022\026\026\021\036\035\016 )0.5(\017\031\004\026\036\n\024\020\024 )0.5(\023\030\017\027\026\022\026, %; )]TJ 0.1 Tw 0 -1.218 TD (q)Tj /Span<>> BDC ( )Tj EMC (\227 \(100-p\); t)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\r\036\030\017\021\036\035\034\027\t\005 \022\024\220\235\235\ \017\006\017\036\027\021, \023\024)Tj 0 Tw (-)Tj 0.15 Tw T* (\022\026\t\r\026\033\013\017\005, \022\026\022\024\r\026 \r\036\030\024\ \016\021\027\024\f\021\034 \021\024\020\024, \004\021\024 \030\026\n\036\ \030\t )Tj -0.044 Tw T* [(\023\024\022\026\026\021\036\035\016 )0.5(\027\036 \002\031\007\031\021 \r\t\b\024\007\017\021\034 )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\020\030\026\027\017\006\t )0.5(\023\030\036\007\036\035\034\027\024\005 )]TJ 0.126 Tw T* (\024\001\017\002\022\017 \(\024\002\t\004\027\024 t)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (2, \004\021\024 \024\002\036\f\023\036\004\017\r\026\036\021 95% \r\036\030\ \024)Tj 0 Tw (-)Tj 0.104 Tw T* (\016\021\027\024\f\021\034 \002\036\024\001\017\002\024\004\027\024\020\ \024 \023\030\024\020\027\024\026\); \254)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\036\007\036\035\034\027\026\016 )Tj 0.041 Tw T* (\024\001\017\002\022\026 \023\024\022\026\026\021\036\035\016 [23]. \200\ )Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \030\026\f\004\036\021\026 \024\002\ \255\036\n )Tj 0 Tw T* (\r\t\002\024\030\022\017 \f\024\f\021\026\r\017\035 144 \(48)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (48)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (48\) \023\026\006\017\036\027\021\026.)Tj 0.053 Tw T* [(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 )0.6(\024\002\030\026\002\024\021\022\026 )0.5(\007\026\027\027\t\b )0.6(\023\030\024\r\024\007\017\035\026\f\034 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC 20.803 0 Td (\017\f)Tj 0 Tw (-)Tj -0.054 Tw -20.803 -1.218 Td [(\023\024\035\034\024\r\026\027\017\036\n )0.5(\023\026\022\036\021\026 \023\030\017\022\035\026\007\027\t\b \023\030\024\ \020\030\026\n\n S)15(t)15(a)15(t)-32(ist)-31.9(ica )]TJ 0.228 Tw T* [(13.3 \(TIBC)13(O, \222\231\202\). \212\035\016 \024\006\036\027\022\017 \030\026\f\023\030\ \036\007\036\035\036\027\017\016 \022\024)]TJ 0 Tw (-)Tj 0.576 Tw T* (\035\017\004\036\f\021\r\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005 \023\030\017\n\036\027\016\035\f\016 \022\030\017\021\036\030\017\ \005 )Tj 0.365 Tw T* [(\231\026\023\017\030\024\226\211\017\035\022\026. )0.6(\215\024\f\022\024\035\034\022\031 )0.5(\030\026\f\023\030\036\007\036\035\036\027\017\016 )0.6(\024\021\035\017\004\026)]TJ 0 Tw (-)Tj 0.064 Tw T* (\035\017\f\034 \024\021 \027\024\030\n\026\035\034\027\024\020\024, \007\ \035\016 \017\b \024\023\017\f\026\027\017\016 \017\f\023\024\035\034\024\ \r\026\035\017 )Tj 0.131 Tw T* (\n\036\007\017\026\027\031 \(Me\) \017)Tj /Span<>> BDC ( )Tj EMC (\017\027\021\036\030\022\r\026\030\021\017\035\034\027\t\005 \030\026\n\ \026\b [Q1; Q3]. )Tj 0.152 Tw 23.244 64.543 Td (\222\030\026\r\027\036\027\017\036 \022\024\035\017\004\036\f\021\r\036\027\ \027\t\b \023\024\022\026\026\021\036\035\036\005 \n\036\032\007\031 \021\ \030\036)Tj 0 Tw (-)Tj 0.138 Tw T* (\n\016 \020\030\031\023\023\026\n\017 \023\030\024\r\024\007\017\035\024\ \f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \027\036\023\026\030\026\n\036\021\030\017)Tj 0 Tw (-)Tj 0.334 Tw T* (\004\036\f\022\024\020\024 H-\022\030\017\021\036\030\017\016 \025\030\026\ \f\022\036\035\026\226\211\024\035\035\017\f\026. \222\030\026\r\027\036\ \027\017\036 )Tj 0.02 Tw T* (\022\026\004\036\f\021\r\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005 \024\f\031\013\036\f\021\r\035\016\035\024\f\034 \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034)Tj 0 Tw (-)Tj 0.055 Tw T* (\024\r\026\027\017\036\n \022\030\017\021\036\030\017\016 \245\262 \215\ \017\030\f\024\027\026. \211\030\024\r\036\027\034 \f\021\026\021\017\f\021\ \017\004\036)Tj 0 Tw (-)Tj T* (\f\022\024\005 \027\026\004\017\n\024\f\021\017 \002\t\035 \031\f\021\026\ \027\024\r\035\036\027 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\036 )Tj /T1_3 1 Tf (p)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 0.064 Tw T* [(\212\035\016 )0.5(\023\030\024\020\027\024\017\030\024\r\026\027\017\016 )0.6(\030\017\f\022\026 )0.5(\030\026\r\017\021\017\016 )0.6(\030\026\027\027\017\b )0.5(\023\024\f\035\036)]TJ 0 Tw (-)Tj 0.137 Tw T* (\024\023\036\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\ \017\005 \002\t\035\024 \023\030\017\n\036\027\036\027\024 \027\036\005\030\ \024)Tj 0 Tw (-)Tj 0.291 Tw T* [(\f\036\021\036\r\024\036 \n\024\007\036\035\017\030\024\r\026\027\017\036\ . )0.5(\222\021\030\024\017\035\017\f\034 \n\024\007\036\035\017 \n\027\024\020\ \024)]TJ 0 Tw (-)Tj 0.045 Tw 0 -1.218 TD [(\f\035\024\005\027\024\020\024 \023\036\030\f\036\023\021\030\024\027\026\ \(Mul)56(t)-31.9(il)-16(a)15(yer)-24(ed P)30(er)-32(ceptr)-31.9(on, MLP\) )]TJ -0.005 Tw 0 -1.218 TD (\007\035\016 \002\017\027\026\030\027\t\b \006\036\035\036\r\t\b \023\036\ \030\036\n\036\027\027\t\b \253\203\026\035\017\004\017\036 \030\026\027\ \027\017\b )Tj 0.013 Tw 0 -1.218 TD (\024\f\035\024\032\027\036\027\017\005 \023\030\024\n\036\032\027\024\f\021\ \027\024\005 \030\026\027\t\273. \212\035\016 \024\006\036\027\022\017 \023\ \030\024)Tj 0 Tw (-)Tj 0.335 Tw T* [(\020\027\024\f\021\017\004\036\f\022\024\005 )0.6(\f\023\024\f\024\002\027\024\f\021\017 )0.6(\n\024\007\036\035\036\005 )0.5(\017\f\023\024\035\034\024\r\026\035\f\016 )]TJ /T1_3 1 Tf -0.019 Tc 0.019 Tw T* [(RO)-19(C)]TJ /T1_1 1 Tf 0 Tc 0 Tw 1.469 0 Td (-\026\027\026\035\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 529.9818 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 10 0 0 10 274.9606 505.6258 Tm (\225\004\006\004\220\003\r\006\t\217\003\t\220\004 \n\006\210\212\212 \217\ \006\004\b\r\b\t\235)Tj /T1_1 1 Tf 0.036 Tw T* [(\215\030\017 )0.5(\026\027\026\035\017\036 )0.6(\024\002\013\036\005 )0.5(\b\026\030\026\022\021\036\030\017\f\021\017\022\017 )0.6(\023\026\006\017\036\027\021\024\r )0.5(\020\030\031\023\023 )]TJ 0.165 Tw T* [(\f\030\026\r\027\036\027\017\016 \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )0.5(\027\026\004\017\n\t\b \030\026\035\017\004\017\005 \r\t\016\r)]TJ 0 Tw (-)Tj 0.059 Tw T* (\035\036\027\024 \027\036 \002\t\035\024. \211\004\017\021\t\r\026\016, \ \004\021\024 \022\026\004\036\f\021\r\024 \031\007\026\035\036\027\017\016\ \023\030\036)Tj 0 Tw (-)Tj -0.002 Tw T* (\023\026\030\026\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 \b\026\030\026\022\021\036\030\017\f\021\017\022\017 \n\024\ \020\031\021 \r\035\017\016\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\006\036\f\f )Tj 0.179 Tw T* (\026\032\017\r\035\036\027\017\016 \023\030\024\n\036\032\027\024\f\021\ \027\024\005 \030\026\027\t, \023\030\024\r\036\007\036\027\024 \f\030\026\ \r)Tj 0 Tw (-)Tj 0.112 Tw T* (\027\036\027\017\036 \022\024\035\017\004\036\f\021\r\036\027\027\t\b \017\ )Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\b \023\024\022\026\026\021\036\035\ \036\005, )Tj 0.224 Tw T* [(\023\024\035\031\004\036\027\027\t\b )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\030\036\031\035\034\021\026\021\036 )0.5(\023\026\021\024\020\017\f\021\024\035\024\020\017\004\036\f\022\024\020\ \024 \017\f)]TJ 0 Tw (-)Tj 0.513 Tw T* (\f\035\036\007\024\r\026\027\017\016 \023\030\036\023\026\030\026\021\026\ . \215\036\030\036\004\017\f\035\036\027\027\t\036 \023\024\022\026\026\ \021\036)Tj 0 Tw (-)Tj 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(\013\036\f\021\r\035\036\027\017\036\n \023\030\017\027\006\017\023\026 \ \006\017\035\017\027\007\030\017\004\036\f\022\024\005 \030\036\036\022\ \006\017\017.)Tj 0.282 Tw 23.244 34.098 Td (\203\024\r\t\005 \f\023\024\f\024\002 \023\035\026\f\021\017\022\017 \(1\ -\016 \020\030\031\023\023\026\) \r\022\035\033\004\026\035 \027\036)Tj 0 Tw (-)Tj T* (\f\022\024\035\034\022\024 \220\021\026\023\024\r \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\):)Tj 0.326 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\215\024\f\035\036 )0.5(\n\026\030\022\017\030\024\r\022\017 )0.6(\024\023\036\030\026\006\017\024\027\027\024\020\024 )0.6(\023\024\035\016 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 19.059 0 Td (\031\007\026)Tj 0 Tw (-)Tj 0.096 Tw -20.355 -1.218 Td (\035\036\027\017\016 \023\030\036\023\026\030\026\021\026 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \202,\207\) \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \f\021\024\030\024\027\t \030\026\027\t )Tj -0.016 Tw T* (\r\t\022\030\026\017\r\026\035\f\016, \n\024\002\017\035\017\024\r\t\r\026\ \035\f\016 \017)Tj /Span<>> BDC ( )Tj EMC (\007\036\220\023\017\021\036\035\017\017\030\024\r\026\035)Tj 0 Tw (-)Tj 0.331 Tw T* (\f\016 \022\024\032\027\024-\023\024\007\022\024\032\027\024-\235\026\f\006\ \017\026\035\034\027\t\005 \035\024\f\022\031\021 \001\017\030\017\027\024\ \005 )Tj 0.113 Tw 0 -1.218 TD (3\2264)Tj /Span<>> BDC ( )Tj EMC (\f\n \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\017\021\026\033\013\036\005 \027\024\032\022\036 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \200\). \211)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\024\r )Tj 0.056 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC 0.725 0 Td [(\007\036\235\017\006\017\021\024\n )0.6(\n\016\020\022\017\b )0.5(\021\022\026\027\036\005 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\035\024\f\022\031\021 )0.5(\r\022\035\033\004\026\035\026\f\034 )0.6(\n\036)]TJ 0 Tw (-)Tj -0.725 -1.218 Td (\007\017\026\035\034\027\026\016 \023\024\030\006\017\016 \002\024\035\034\ \001\024\005 \016\020\024\007\017\004\027\024\005 \n\t\001\006\t.)Tj -0.035 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\200\t\022\030\024\036\027\027\t\005 )0.6(\035\024\f\022\031\021 )0.5(\023\024\020\030\031\032\026\035\f\016 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 14.033 0 Td [(\026\023\036\030\021\031\030\031 )0.6(\n\026\035\024\020\024 )]TJ 0.002 Tw -15.329 -1.218 Td (\021\026\026 \017)Tj /Span<>> BDC ( )Tj EMC (\235\017\022\f\017\030\024\r\026\035\f\016 \022)Tj /Span<>> BDC ( )Tj EMC (\021\022\026\027\016\n \023\030\024\021\017\r\024\023\024\035\024\032\027\ \024\005 \f\021\024)Tj 0 Tw (-)Tj -0.05 Tw T* (\030\024\027\t, \004\021\024 \024\002\036\f\023\036\004\017\r\026\035\024\ \024\002\255\036\n\027\024\036 \026\023\024\035\027\036\027\017\036 \007\ \036\235\036\022)Tj 0 Tw (-)Tj -0.036 Tw 0 -1.218 TD (\021\026 \b\024\030\024\001\024 \r\026\f\022\031\035\016\030\017\017\030\ \024\r\026\027\027\t\n\017 \021\022\026\027\016\n\017 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \206\).)Tj 0.413 Tw 0 -1.218 TD (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\222)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\017\r\024\023\024\035\024\032\027\024\005 \f\021\024\030\ \024\027\t \n\024\002\017\035\017\024\r\t\r\026\035\f\016 )Tj 0.324 Tw -1.296 -1.218 Td (\021\030\036\031\020\024\035\034\027\t\005 \022\024\032\027\024-\023\024\ \007\022\024\032\027\024-\235\026\f\006\017\026\035\034\027\t\005 \035\024\ \f\022\031\021 )Tj 0.037 Tw 0 -1.218 TD [(\023\024\007 )0.5(\031\020\035\024\n )0.6(60\22680 )0.5(\020\030\026\007\031\f\024\r )0.5(\024\021 )0.5(\006\036\027\021\030\026 )0.6(\030\026\027\t )0.5(\(\217\017\f.)]TJ /Span<>> BDC ( )Tj EMC 20.19 0 Td [(1 )0.5(\212\), )]TJ 0.056 Tw -20.19 -1.218 Td (\022\024\021\024\030\t\005 \023\036\030\036\n\036\013\026\035\f\016 \007\ \035\016 \026\022\030\t\021\017\016 \022\024\032\027\024\020\024 \007\036\ \235\036\022)Tj 0 Tw (-)Tj 0.015 Tw T* (\021\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\006\017\023\031 \023\036\030\036\n\036\013\036\027\027\t\ \b \021\030\036\031\020\024\035\034\027\t\b \035\024\f\022\031\021\024\r\ )Tj 0.19 Tw T* (\002\036 \027\026\021\016\032\036\027\017\016. \214\024\f\022\031\021 \023\ \036\030\036\n\036\013\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\006\036\027\021\030 \030\026\027\t, )Tj 0.066 Tw T* (\f\024\r\n\036\013\026\016 \r\036\030\001\017\027\031 \021\030\036\031\020\ \024\035\034\027\017\022\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\001\017\027\024\005 \030\024\n\002\026. )Tj 0.189 Tw T* [(\214\024\f\022\031\021 \235\017\022\f\017\030\024\r\026\035\f\016 )0.5(\024\021\007\036\035\034\027\t\n\017 \031\035\024\r\t\n\017 \001\r\026\n\ \017 )]TJ 0 Tw T* (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1 \213\).)Tj 0.138 Tw T* (\200\024 2-\005 \020\030\031\023\023\036 \007\036\235\036\022\021 \031\001\ \017\r\026\035\f\016 \023\024\f\035\024\005\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\r\024\f\f\021\026)Tj 0 Tw (-)Tj 0.295 Tw T* [(\027\024\r\035\036\027\017\036\n \f\036\007\026\035\017\013\027\024-\026\ \027\026\035\034\027\024\005 \022\035\036\021\004\026\021\022\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\022\024\032\017 )Tj 0 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\031\f\021\026\027\024\r\022\024\005 \023\030\024\n\036\032\027\024\f\021\ \027\024\020\024 \007\030\036\027\026\032\026.)Tj 0.161 Tw T* (\200 3-\005 \020\030\031\023\023\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\027\024 \023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\ \t \031\f\021\026\027\026\r)Tj 0 Tw (-)Tj 0.072 Tw T* [(\035\017\r\026\035\f\016 \f\036\021\004\026\021\t\005 )0.5(\017\n\023\035\026\027\021\026\021, \022\024\021\024\030\t\005 \235\017\022\ \f\017\030\024\r\026\035\f\016 )]TJ -0.014 Tw T* (\n\017\027\017\n\031\n \r)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\b \f\017\n\n\036\021\030\017\004\027\024 \030\026\f\023\024\ \035\024\032\036\027\027\t\b \021\024\004\022\026\b: )Tj 0.321 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\026\035\036 \022\030\036\f\021\006\024\r\024-\002\031\020\024\ \030\027\024\005 \f\r\016\022\017 \(\031\020\024\035 \n\036\032\007\031\ )Tj ET q 70.866 122.669 396.85 237.055 re W n q /GS0 gs 396.850395 0 0 237.0545285 70.8661652 122.6695315 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.072 Tw 9 0 0 9 70.8661 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \230\023\020\033\013 \032\027\n\031\025\024\023\032\r\n\006\022\022 \033\ \032\031\026\027\255\025\031\024\023\025\031\235 \032\020\025\013 \033\031\ \024\f\027 \230\f\221\004\230 \033\032\t\026\031\235 \n\022\213\n\022 \033\ \031)Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r \032\020\n\020 \025\022\255\025\027\020\026\033\r\ \f\t\032\025\031\b\031 )Tj 0 Tw 0 -1.2 TD (\031\023\030\027\f\020 \033\032\t\026\031\235 \n\022\213\n\022 \(\n\031\026\ \026\027\025\023\020\032\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\023\027\n\024\023\027\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.002 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( S)28(tag)12(es of)]TJ /Span<>> BDC ( )Tj EMC [(per)-37(ineal w)12(ound reconstruction af)-45.9(ter EL)-36(APE of)]TJ /Span<>> BDC ( )Tj EMC (the rectum for cancer of)Tj /Span<>> BDC ( )Tj EMC [(the low)12.1(er am)16(pullar)-43(y par)-39.9(t of)]TJ /Span<>> BDC ( )Tj EMC (the rectum )Tj 0 Tw T* [(\(see e)-14.9(xplanation in the)]TJ /Span<>> BDC ( )Tj EMC [(te)-14.9(xt\))]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_4 1 Tf 25 0 0 25 28.2152 56.0378 Tm (84)Tj ET endstream endobj 1156 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   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|S}i'f`ά>޵a0&};>V:U! **{y)Ƭ86% FKϾ"p>zX}ӽj]}!ypbGU?+! juKNZ=MQAsxFY F Zb v}ӽkaN4RUMʥ) ?m>t}ӽk vgϺwNȩ*W*J+ӽLٟ:>޵;3G;֧d2ʒ)`t}ӽk_ΏwNIT$ǂd=t}kǶWΏN̩*B$2PUz{?:>c''?֧fUJ ays8WZɹWݒ4}i_ 6_ΏwN̨!.AwU%SN|`4}ӽjveDTJUV!$'R{ x-u}ӽi>ǶP2)zvd "!IS:ACέɃvam22:No*J+T endstream endobj 1160 0 obj <>stream endstream endobj 1154 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.02 Tw 10 0 0 10 42.5197 724.8299 Tm (\023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \035\024\022\026\004\036\f\021\r\036\027\027\t\b\ \024\023\031\b\024\035\036\005 \220\021\024\005 \035\024\022\026\035\017\ \026)Tj 0 Tw (-)Tj 0.001 Tw 0 -1.218 TD (\006\017\017, \027\024 \f\024\023\030\024\r\024\032\007\026\035\026\f\034\ \r\t\f\024\022\024\005 \004\026\f\021\024\021\024\005 \023\024\f\035\036\ \024\023\036)Tj 0 Tw (-)Tj 0.05 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005 \ \(\007\024 49%\) \017)Tj /Span<>> BDC ( )Tj EMC (\035\024\022\026\035\034\027\t\b \030\036\006\017)Tj 0 Tw (-)Tj T* (\007\017\r\024\r \(\007\024 40%\) [1,2].)Tj -0.002 Tc 0.177 Tw T* (\210\007\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\033\004\036\r\t\b \007\024\f\021\017\032\036\027\017\005 \023\024\ \f\035\036\007\027\017\b \007\036\f\016\021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.07 Tw T* [(\035\036\021\017\005 \f\021\026\035\024 \r\027\036\007\030\036\027\017\036\ \022\024\027\006\036\023\006\017\017 \220\022\f\021\030\026\035\036\r\026\ \021\024\030\027\024\005)-2( )]TJ 0.278 Tw 0 -1.218 TD (\002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\024\005\ \220\022\f\021\017\030\023\026\006\017\017 \(\233\035\207\215\233\) \023\ \030\016)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.001 Tw 0 -1.218 TD [(\n\024\005 )0.6(\022\017\001\022\017, )0.6(\023\030\036\007\035\024\032\036\027\027\024\005 )0.5(Holm )0.6(T. )0.6(e)-12(t )0.6(al. )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 17.463 0 Td [(2007 )0.6(\020. )0.5([2].)-2( )]TJ -0.017 Tw -17.463 -1.218 Td [(\222\024\020\035\026\f\027\024 \220\021\024\005 \022\024\027\006\036\023\ \006\017\017, \031\035\031\004\001\036\027\017\036 \024\027\022\024\035\024\ \020\017\004\036\f\022\017\b)-2( )]TJ 0.095 Tw T* (\030\036\031\035\034\021\026\021\024\r \007\024\f\021\017\020\026\036\021\ \f\016 \026)Tj /Span<>> BDC ( )Tj EMC [(\f\004\036\021 \030\026\f\001\017\030\036\027\017\016 \024\002\255\036\n\ \026)-2( )]TJ 0.458 Tw T* [(\r\n\036\001\026\021\036\035\034\f\021\r\026, )0.5(\r\022\035\033\004\026\033\013\036\020\024 )0.5(\031\007\026\035\036\027\017\036 )0.5(\026\027\026\035\034\027\024\020\024)-2( )]TJ 0.2 Tw T* [(\022\026\027\026\035\026, )0.5(\r\f\036\005 )0.5(\n\t\001\006\t, )0.5(\023\024\007\027\017\n\026\033\013\036\005 )0.5(\026\007\027\017\005 )0.5(\023\030\024\b\024\007,)-2( )]TJ 0.031 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\017 [2,4,5]. \215\024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n A)-24.9(ggar)-38(w)-12(al N. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.2 Tw 0 -1.218 TD [(\026\r\021., \021\026\022\024\005 \023\024\007\b\024\007 \024\002\036\f\023\ \036\004\017\r\026\036\021 \f\027\017\032\036\027\017\036 \004\026\f\021\ \024\021\t)-2( )]TJ 0.105 Tw 0 -1.218 TD (\n\036\f\021\027\024\020\024 \030\036\006\017\007\017\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (30\22640% \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.135 Tw T* [(\n\036\027\036\027\017\036\n \207\215\233 \215\025 [6]. W)22(est N.P. \017)]TJ /Span<>> BDC ( )Tj EMC (\f\024\026\r\021., \r)Tj /Span<>> BDC ( )Tj EMC (\n\031\035\034\021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.074 Tw T* (\006\036\027\021\030\024\r\024\n \017\f\f\035\036\007\024\r\026\027\017\017\ , \024\023\031\002\035\017\022\024\r\026\027\027\024\n \r)Tj /Span<>> BDC ( )Tj EMC (2010)Tj /Span<>> BDC ( )Tj EMC [(\020.,)-2( )]TJ 0.586 Tw T* [(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\035, \004\021\ \024 \233\035\207\215\233 \f\027\017\032\026\036\021 \004\026\f\021\024\021\ \031)-2( )]TJ 0.032 Tw T* (CRM+)Tj /Span<>> BDC ( )Tj EMC (\f 49,6% \007\024)Tj /Span<>> BDC ( )Tj EMC (20,3%, \026)Tj /Span<>> BDC ( )Tj EMC (\004\026\f\021\024\021\031 \023\036\030\235\024\030\026\006\017\017 \024\ \023\031\b\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.112 Tw T* (\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (28,2% \007\024)Tj /Span<>> BDC ( )Tj EMC [(8,2% [7]. \217\016\007 \017\f\f\035\036\007\024\r\026\027\017\005 \023\024\ \022\026\026\035\017)-2( )]TJ 0.07 Tw T* (\f\b\024\032\017\036 \030\036\031\035\034\021\026\021\t [3,8\22613]. \210\ \007\027\026\022\024 \233\035\207\215\233 \026\f\f\024\006\017\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc -0.02 Tw T* (\030\031\036\021\f\016 \f)Tj /Span<>> BDC ( )Tj EMC [(\r\t\f\024\022\017\n\017 \023\024\022\026\026\021\036\035\016\n\017 \023\ \024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b)-2( )]TJ -0.017 Tw T* [(\024\f\035\024\032\027\036\027\017\005 \030\026\027 \023\030\024\n\036\032\ \027\024\f\021\017 \(\235\024\030\n\017\030\024\r\026\027\017\036 \f\036\ \030\024\n,)-2( )]TJ 0.414 Tw T* [(\030\026\r\017\021\017\036 \020\027\024\005\027\024-\f\036\023\021\017\004\ \036\f\022\017\b \024\f\035\024\032\027\036\027\017\005, \027\036\022\030\ \024)-2( )]TJ 0.118 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\f\b\024\032\007\036\027\017\036 \022\030\026\036\r \023\024\f\035\ \036\024\023\036\030\026\006\017\024\027\027\t\b \030\026\027, \235\024\030\ )Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.119 Tw T* (\n\017\030\024\r\026\027\017\036 \b\030\024\027\017\004\036\f\022\017\b \ \f\r\017\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\b\030\024\027\017\004\036\f\022\024\020\024 \002\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.217 Tw T* [(\035\036\r\024\020\024 \f\017\027\007\030\024\n\026\), \023\024\f\022\024\ \035\034\022\031 \024\027\026 \024\002\030\026\031\036\021 \023\024\035\ \024\f\021\034)-2( )]TJ 0.045 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017 \002\024\035\034\001\036\020\024\ \030\026\n\036\030\026, \004\036\n \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\027\007\026\030\021)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.143 Tw T* [(\027\024\005 )0.5(\207\215\233 )0.5(\215\025 )0.5([3,6,14\22619]. )0.6(\025)]TJ /Span<>> BDC ( )Tj EMC 11.664 0 Td [(\f\024\032\026\035\036\027\017\033, )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 6.088 0 Td [(\027\026\f\021\024\016\013\036\036)-2( )]TJ 0.448 Tw -17.752 -1.218 Td [(\r\030\036\n\016 \027\036 \f\031\013\036\f\021\r\031\036\021 \024\023\021\ \017\n\026\035\034\027\t\b \030\036\022\024\n\036\027\007\026\006\017\005\ )-2( )]TJ 0.054 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC [(\r\t\002\024\030\031 \021\024\020\024 \017\035\017 \017\027\024\020\024 \ \f\023\024\f\024\002\026 \023\035\026\f\021\017\022\017 \007\036\235\036\ \022\021\026)-2( )]TJ 0.04 Tw T* [(\021\026\024\r\024\020\024 \007\027\026. \213\f\035\017 \026\031\021\024\ \023\035\026\f\021\017\022\026 \(\023\030\024\f\021\024\036 \023\024\f\035\ \024\005\027\024\036)-2( )]TJ 0.027 Tw T* [(\031\001\017\r\026\027\017\036 \023\030\024\n\036\032\027\024\f\021\027\024\ \005 \030\026\027\t\), \023\030\017\n\036\027\016\036\n\026\016 \023\024\ \f\035\036)-2( )]TJ 0.134 Tw T* [(\207\215\233 )0.5(\215\025, \024\002\036\f\023\036\004\017\r\026\036\021 \r)]TJ /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \b\024\ \030\024)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.053 Tw T* [(\001\017\005 \030\036\031\035\034\021\026\021, \021\024 \023\024\f\035\036\ \233\035\207\215\233 \220\021\026 \021\036\b\027\017\022\026 \027\036 \r\ \f\036\020\007\026)-2( )]TJ 0.101 Tw T* [(\007\026\036\021 \r\024\n\024\032\027\024\f\021\034 \007\024\002\017\021\ \034\f\016 \023\024\035\027\024\020\024 \026\022\030\t\021\017\016 \030\ \026\027\t.)-2( )]TJ 0.157 Tw T* (\025\030\024\n\036 \021\024\020\024, \027\026\004\017\021\036\035\034\027\ \t\005 \030\026\027\036\r\024\005 \007\036\235\036\022\021 \023\030\024\n\ \036\032)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.121 Tw T* (\027\024\f\021\017 \027\026\030\016\007\031 \f)Tj /Span<>> BDC ( )Tj EMC (\027\017\022\024\005 \f\023\024\f\024\002\027\024\f\021\034\033 \022)Tj /Span<>> BDC ( )Tj EMC [(\026\032\017\r\035\036\027\017\033)-2( )]TJ 0.317 Tw T* [(\023\024\f\035\036 )0.5(\023\030\024\r\036\007\036\027\027\024\005 )0.5(\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\005 )0.5(\b\017\n\017\024\035\031\004\036)]TJ 0 Tc 0 Tw (-)Tj -0.002 Tc 0.129 Tw T* (\r\024\005 \021\036\030\026\023\017\017 \f\023\024\f\024\002\f\021\r\031\ \036\021 \030\026\r\017\021\017\033 \030\016\007\026 \023\024\f\035\036\ \024\023\036)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.098 Tw T* (\030\026\006\017\024\027\027\t\b \024\f\035\024\032\027\036\027\017\005,\ \r)Tj /Span<>> BDC ( )Tj EMC [(\021\024\n \004\017\f\035\036 \235\024\030\n\017\030\024\r\026\027\017\033\ )-2( )]TJ 0.199 Tw T* (\023\030\024\n\036\032\027\024\f\021\027\024\005 \020\030\t\032\017. \215\ \024)Tj /Span<>> BDC ( )Tj EMC [(\007\026\027\027\t\n \030\026\027\t\b \026\r\021\024\030\024\r)-2( )]TJ 0.002 Tw T* (\030\026\r\017\021\017\036 \220\021\024\020\024 \024\f\035\024\032\027\036\ \027\017\016 \022\024\035\036\002\035\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\023\030\036\007\036\035\026\b \024\021)-2( )]TJ 0.081 Tw T* (3,3% \007\024)Tj /Span<>> BDC ( )Tj EMC [(67% [3,14,15]. \207\024\035\034\001\017\027\f\021\r\024 \017\f\f\035\036\ \007\024\r\026\021\036\035\036\005)-2( )]TJ 0.247 Tw T* (\031\021\r\036\030\032\007\026\033\021, \004\021\024 \023\030\026\r\017\035\ \034\027\t\005 \r\t\002\024\030 \023\024\f\035\036\024\023\036\030\026\006\ \017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.006 Tw T* [(\024\027\027\024\005 \030\036\022\024\027\f\021\030\031\022\006\017\017 \ \023\030\024\n\036\032\027\024\f\021\017 \016\r\035\016\036\021\f\016 \026\ \035\024\020\024\n)-2( )]TJ 0.252 Tw T* [(\f\027\017\032\036\027\017\016 \030\017\f\022\024\r \030\026\r\017\021\017\ \016 \030\026\035\017\004\027\t\b \024\f\035\024\032\027\036\027\017\005\ )-2( )]TJ 0.15 Tw T* ([6,18,19]. \203\026)Tj /Span<>> BDC ( )Tj EMC [(\f\036\020\024\007\027\016\001\027\017\005 \007\036\027\034 \024\023\017\ \f\026\027\024 \n\027\024\032\036\f\021\r\024)-2( )]TJ 0.054 Tw T* (\n\036\021\024\007\017\022)Tj /Span<>> BDC ( )Tj EMC [(\227 \024\021 \023\030\024\f\021\024\020\024 \031\001\017\r\026\027\017\016\ \n\036\f\021\027\t\n\017 \021\022\026\027\016\n\017)-2( )]TJ -0.038 Tw T* (\007\024)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\032\027\t\b \030\036\022\024\027\f\021\030\031\022\006\017\005\ \f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \n\t\001\036\004)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.07 Tw T* [(\027\024-\022\024\032\027\t\b \035\024\f\022\031\021\024\r \(VRAM-\035\024\ \f\022\031\021, \020\030\026\006\017\035\024\023\035\026\f\021\017\022\026\ ,)-2( )]TJ 0.232 Tw T* (\016\020\024\007\017\004\027\t\036 \035\024\f\022\031\021\t\) \017)Tj /Span<>> BDC ( )Tj EMC (\002\017\024\035\024\020\017\004\036\f\022\017\b \017\035\017 \f\017\027\ \021\036\021\017)Tj 0 Tc 0 Tw (-)Tj -0.002 Tc 0.35 Tw T* [(\004\036\f\022\017\b \f\036\021\004\026\021\t\b \017\n\023\035\026\027\021\ \026\021\024\r [5,20]. \207\024\035\034\001\017\027\f\021\r\024)-2( )]TJ -0.062 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 1.11 0 Td [(\027\017\b )0.5(\f\035\024\032\027\t \r)]TJ /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\027\036\027\017\017 \017)Tj /Span<>> BDC ( )Tj EMC 11.419 0 Td [(\027\036 )0.5(\017\f\022\035\033\004\026\033\021 )0.5(\030\026\r\017\021\017\036)-2( )]TJ -0.055 Tw 10.716 64.543 Td (\030\026\027\027\017\b \017)Tj /Span<>> BDC ( )Tj EMC [(\023\024\007\027\017\b \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\t\b \024\f\035\024\032\027\036\027\017\005 \f\024)-2( )]TJ 0 Tw T* (\f\021\024\030\024\027\t \030\026\027\t, \035\024\f\022\031\021\024\r, \026\ )Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \007\024\027\024\030\f\022\017\b \031\004\026\f\021\ \022\024\r.)Tj 0 Tc 0.052 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \022\024\027\f\036\027\f\031\ \f \024\021\027\024\f\017\021\036\035\034\027\024 \030\036\022\024\027\f\ \021\030\031\022)Tj 0 Tw (-)Tj -0.039 Tw T* (\006\017\017 \023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\ \t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\020\024 \007\027\026 \023\024\f\035\036 \233\035\207\ \215\233 )Tj 0.109 Tw T* [(\023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC [(\027\026\f\021\024\016\013\036\036 )0.6(\r\030\036\n\016 )0.5(\024\021\f\031\021\f\021\r\031\036\021, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 20.789 0 Td (\030\036)Tj 0 Tw (-)Tj 0.125 Tw -20.789 -1.218 Td [(\031\035\034\021\026\021\t \f\030\026\r\027\017\021\036\035\034\027\t\b\ )0.5(\017\f\f\035\036\007\024\r\026\027\017\005 \004\026\f\021\024 \023\030\024\ \021\017)]TJ 0 Tw (-)Tj -0.016 Tw 0 -1.218 TD [(\r\024\030\036\004\017\r\t, \004\021\024 \023\024\007\004\036\030\022\017\ \r\026\036\021 \027\036\024\002\b\024\007\017\n\024\f\021\034 )0.5(\007\026\035\034\027\036\005)]TJ 0 Tw (-)Tj 0 -1.218 TD (\001\017\b \017\t\f\022\026\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \027\026\023\030\026\r\035\036\027\017\017 [21,22\ ].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 603.0498 Tm [(\017\034\r\237)5( \031\032\032\r\034\230\037\023\026\022\031\025)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.544 Tw 10 0 0 10 274.9606 578.6938 Tm (\211\035\031\004\001\036\027\017\036 \030\036\031\035\034\021\026\021\024\ \r \023\035\026\f\021\017\022\017 \023\030\024\n\036\032\027\024\f\021\027\ \024\005 )Tj 0.115 Tw T* (\030\026\027\t \023\024\f\035\036 \233\035\207\215\233 \023\030\016\n\024\ \005 \022\017\001\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\024\007\031 \027\017\032\027\036)Tj 0 Tw (-)Tj 0.029 Tw T* (\026\n\023\031\035\016\030\027\024\020\024 \030\026\022\026 \023\031\021\ \036\n \023\030\017\n\036\027\036\027\017\016 \027\024\r\024\020\024 \f\023\ \024\f\024\002\026 )Tj 0 Tw 0 -1.218 TD (\023\035\026\f\021\017\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 275.0305 505.6258 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 10 0 0 10 274.9606 481.2698 Tm (\031\t\213\004\005\b \t\217\217\f\r\240\002\004\b\t\235 \t)Tj /Span<>> BDC ( )Tj EMC (\234\003\t\201\r\217\220\t\r \004\217\212\r\220\003\013)Tj /T1_1 1 Tf 0.105 Tw 0 -1.218 TD (\230\f\f\035\036\007\024\r\026\027\017\036 \n\027\024\020\024\006\036\027\ \021\030\024\r\024\036, \030\026\027\007\024\n\017\017\030\024\r\026\027\ \027\024\036, )Tj 0.393 Tw T* (\022\024\027\021\030\024\035\017\030\031\036\n\024\036, \r\t\023\024\035\ \027\036\027\027\024\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\002\026\036 \022\024\035\024\023\030\024\022)Tj 0 Tw (-)Tj 0.102 Tw T* [(\021\024\035\024\020\017\004\036\f\022\024\020\024 )0.5(\024\021\007\036\035\036\027\017\016 )0.5(\206\207\211\003 )0.5(\203\230\230)]TJ /Span<>> BDC ( )Tj EMC 15.375 0 Td [(\227 )0.5(\025\025\207 \223 )0.5(1 \017\n. )]TJ 0.074 Tw -15.375 -1.218 Td (\023\030\024\235. \222.\200.)Tj /Span<>> BDC ( )Tj EMC (\210\004\026\023\024\r\f\022\024\020\024 \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\007\036\035\036\027\017\016 \026\002\007\024\n\017\027\026\035\034\ \027\024\005 )Tj 0.201 Tw T* (\024\027\022\024\035\024\020\017\017 \206\207\211\003 \025\210\212 \223 \ 1 \(\020.)Tj /Span<>> BDC ( )Tj EMC (\025\030\026\f\027\024\007\026\030\) \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 )Tj 0.166 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\024\022\021\016\002\030\016 2022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\026\005 2025 \020\020. \215\030\024\021\024\022\024\035 \017\f\f\035\036\ \007\024)Tj 0 Tw (-)Tj 0.061 Tw T* (\r\026\027\017\016 \002\t\035 \024\007\024\002\030\036\027 \035\024\022\026\ \035\034\027\t\n \220\021\017\004\036\f\022\017\n \022\024\n\017\021\036\ \021\024\n )Tj 0.004 Tw T* (\(\215\030\024\021\024\022\024\035 \223112 \024\021 12.10.2022 \020.\) \017\ )Tj /Span<>> BDC ( )Tj EMC (\026\030\036\020\017\f\021\030\017\030\024\r\026\027 )Tj 0.111 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\007\031\027\026\030\024\007\027\024\n \030\036\036\f\021\030\036\ \030\026\027\007\024\n\017\017\030\024\r\026\027\027\t\b \022\024\027)Tj 0 Tw (-)Tj 0.007 Tw T* (\021\030\024\035\017\030\031\036\n\t\b \017\f\f\035\036\007\024\r\026\027\ \017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\f\026\005\021\036 Cl)-31(inical)56.1(tr)-37(ial.gov: )]TJ 0.046 Tw T* (IDNCT06066931. \230\f\f\035\036\007\024\r\026\027\017\036 \023\030\024\r\ \036\007\036\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\024\021\r\036\021)Tj 0 Tw (-)Tj T* (\f\021\r\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\216\036\035\034\f\017\027\022\f\022\024\005 \007\036\022\035\026\030\026\ \006\017\036\005.)Tj /T1_4 1 Tf T* (\202\032\022\023\027\032\022\022 \021\n\f\005\007\027\025\022\t \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027:)Tj /T1_1 1 Tf 0.052 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\026\006\017\036\027\021\t \f\021\026\030\001\036 18 \035\036\021, \f\ \021\030\026\007\026\033\013\017\036 \030\026\022\024\n \027\017\032)Tj 0 Tw (-)Tj 0.15 Tw -1.296 -1.218 Td (\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021\007\036\035\026\ \023\030\016\n\024\005 \022\017\001\022\017 \fT1-T4N0-2M0 )Tj 0.174 Tw T* [(\(\023\024 \022\035\026\f\f\017\235\017\022\026\006\017\017 \035\024\022\ \026\004\036\f\021\r\036\027\027\t\b )0.5(\024\023\031\b\024\035\036\005 TNM )]TJ 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (8-\005 \030\036\007\026\022\006\017\017\).)Tj T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\026\006\017\036\027\021\t \f)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\017\030\031\036\n\024\005 \233\035\207\215\233 \023\030\ \016\n\024\005 \022\017\001\022\017.)Tj 0.152 Tw -1.296 -1.218 Td (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(\205\017\017\004\036\f\022\017\005 \f\021\026\021\031\f )0.5(\023\026\006\017\036\027\021\024\r \023\024)]TJ /Span<>> BDC ( )Tj EMC (\022\035\026\f\f\017\235\017\022\026\006\017\017 )Tj 0 Tw -1.296 -1.218 Td [(A)35(SA I-II.)]TJ 0.073 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\024\007\023\017\f\026\027\027\024\036 \017\027\235\024\030\n\017\030\ \024\r\026\027\027\024\036 \f\024\020\035\026\f\017\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (\031\004\026)Tj 0 Tw (-)Tj -1.296 -1.218 Td (\f\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\017.)Tj /T1_4 1 Tf T* (\202\032\022\023\027\032\022\022 \025\027 \021\n\f\005\007\027\025\022\t\ :)Tj /T1_1 1 Tf T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\215\035\024\f\022\024\022\035\036\021\024\004\027\t\005 \030\026\022 \023\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\017\235\017\022\026\006\017\017 \007\017\026\020\027\024\026\ )Tj 0.013 Tw -1.296 -1.218 Td (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\203\026\035\017\004\017\036 \024\f\021\030\t\b \020\027\024\005\027\t\b\ \023\030\024\006\036\f\f\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \b\017\030\031\030)Tj 0 Tw (-)Tj 0.058 Tw -1.296 -1.218 Td (\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\f\021\ \r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\n\036\032\027\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\r \022\030\036\f\021)Tj 0 Tw (-)Tj T* (\006\024\r\024-\022\024\023\004\017\022\024\r\024\005 \024\002\035\026\f\ \021\017.)Tj /T1_4 1 Tf T* (\202\032\022\023\027\032\022\022 \022\024\n\f\005\007\027\025\022\t \022\ \016)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\t:)Tj /T1_1 1 Tf 0.464 Tw T* (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\210\021\022\026 \023\026\006\017\036\027\021\024\r \024\021 \031\004\026\ \f\021\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\n \220\021\026\023\036 )Tj 0 Tw -1.296 -1.218 Td (\017\f\f\035\036\007\024\r\026\027\017\016.)Tj /T1_4 1 Tf T* (\004\032\022\025\006\022\033 \032\020\024\033\032\027\030\027\f\027\025\022\ \t \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\013)Tj /T1_1 1 Tf 0.456 Tw T* (\217\026\f\023\030\036\007\036\035\036\027\017\036 \023\026\006\017\036\027\ \021\024\r \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \023\030\024\r\024\007\017\035\024\f\034 )Tj 0.408 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\024\n\024\013\034\033 \022\024\n\023\034\033\021\036\030\027\024\005\ )0.5(\023\030\024\020\030\026\n\n\t \020\036\027\036\030\026\021\024\030\026 \ )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tw 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8394 56.0378 Tm (83)Tj ET endstream endobj 1153 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 296.9706 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 296.9706 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 259.7628 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 259.7628 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 205.6936 cm 0 0 m 453.543 0 l S Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 119.1012 723.8861 Tm [(Reconstr)10.1(uction of\022)-23.3(perineal w)11(ound and pelvic floor )]TJ 0.929 -1.167 Td [(af)-31(ter e)21(xtr)21(ale)11(v)10(ator abdominoperineal e)21(x)21(cision )]TJ 0.004 -1.167 Td [(of\022)-23.3(th)11(e r)31.1(ectum: a\022)-23.3(nov)12(el solution to\022)-23.2(th)11(e pr)20(oblem )]TJ 0.528 -1.167 Td [(\(r)31(esults of\022)-23.3(a\022)-23.3(multicenter r)21.1(andomiz)10(ed study\))]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 636.3822 Tm [(V)31(adim\022)-23.3(V)62(.\022)-23.2(P)9.9(olovinkin)]TJ 8.162 0 0 8.162 181.6265 641.0442 Tm (2,3)Tj 0.023 Tw 14 0 0 14 193.5102 636.3822 Tm [(, Nik)11(olay\022)-23.2(V)62(.\022)-23.3(Dor)20(onin)]TJ 0 Tw 8.162 0 0 8.162 309.0065 641.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 313.6425 636.3822 Tm [(, Ruslan M.-)-42(A)-31(. Shir)21.1(aliy)10(e)11(v)]TJ 0 Tw 8.162 0 0 8.162 454.0441 641.0442 Tm (1)Tj 14 0 0 14 458.6801 636.3822 Tm (, )Tj -27.701 -1.143 Td [(Ale)21(x)11(an\022)-23.2(A)-31(.\022)-23.3(Khalaf)-31(y)21(an)]TJ 8.162 0 0 8.162 188.7664 625.0442 Tm (4)Tj 0.023 Tw 14 0 0 14 193.4024 620.3822 Tm [(, V)31(aleriy\022)-23.2(B.\022)-23.3(K)41(aushansky)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 325.1384 625.0442 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 336.459 620.3822 Tm [(, Ev)10(geniy\022)-23.2(A)-31(.\022)-23.3(Ermak)11(ov)]TJ 0 Tw 8.162 0 0 8.162 457.4158 625.0442 Tm (1)Tj 5.83 0 0 5.83 70.8661 606.043 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 602.713 Tm [(Clinical Oncology Dispensar)-30.9(y No. 1 \(Dimitr)20(ov)10(a\022)-23.2(st., 1)150(46, Kr)21.1(asnodar)52(, 3500)25(40, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 594.043 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 590.713 Tm [(Scientif)-20.9(ic Resear)31(ch Institute\022)-23.2(\230 Ochapov)10(sky Regional Clinical Hospital No. 1 \(1st May\022)-23.3(st., 1)112(6)58.1(7)127(, Kr)21(asnodar)52(, )]TJ -0.331 -1.2 Td (350086, Russia\))Tj 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 570.043 Tm (3)Tj 0.023 Tw 10 0 0 10 74.1775 566.713 Tm [(K)31(uban State Medical Univ)12.1(er)20(sit)-20(y \(Sedina\022)-23.2(st., 4, Kr)21(asnodar)52(, 350063, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 558.0431 Tm (4)Tj 0.023 Tw 10 0 0 10 74.1775 554.7131 Tm [(K)31(uban State Univ)12(er)20(sit)-19.9(y \(Stavr)20(opolskay)21.1(a\022)-23.3(st., 1)150(49, Kr)21(asnodar)52(, 3500)25(40, Russia\))]TJ /T1_1 1 Tf 0.006 Tw 9 0 0 9 119.0551 536.2091 Tm [(AIM: to im)16(p)46(rov)13(e the outcomes of per)-36.9(ineal w)12(ound reconstruction af)-46(ter EL)-35.9(APE for low rectal cancer by applying a ne)10(w )]TJ 0.023 Tw 0 -1.111 TD [(reconstructiv)13.1(e techniq)14(ue.)]TJ 0.129 Tw T* [(P)45(A)45(TIENT)-9.9(S A)53(ND METHODS: a cohor)-40(t multicenter randomized controlled tr)-37(ial included 150 patients, allocated into )]TJ 0.104 Tw T* [(three g)14(roups depending on the per)-36.9(ineal w)12(ound reconstruction techniq)14(ue: ne)10(w techniq)14(ue \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\), sim)16(ple w)12(ound )]TJ 0.011 Tw T* (closure \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50\), mesh repair \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\). The time of the reconstruction stag)12(e, blood loss, pain intensity)42(, freq)14(uency of )]TJ 0.035 Tw 0 -1.111 TD [(early )0.6(\(up )0.5(to )0.6(30 )0.5(d)26(ays\) )0.6(\(seroma, )0.6(hematoma, )0.6(suppuration, )0.6(f)-22(lap )0.6(necrosis\) )0.6(and )0.5(late )0.5(\(median )0.5(14 )0.5(months\) )0.5(postoperativ)13(e )]TJ -0.01 Tw 0 -1.111 TD [(com)16(plications \(f)-42.9(istulas, abscesses, per)-37(ineal her)-14(nias, chronic pain syndrome\) w)12(ere studied; patient q)14(uality of life w)13(as )]TJ 0 Tw 0 -1.111 TD (assessed.)Tj 0.032 Tw 0 -1.111 TD [(RESUL)30(T)-10(S: the time of the reconstruction stag)12(e w)13(as long)12.1(er in the ne)10(w techniq)14(ue g)14(roup \(50 [45; 55] min\) com)16(pared )]TJ 0.036 Tw 0 -1.111 TD [(to 20 [20; 25] min for sim)16.1(ple closure and 35 [30; 40] min for mesh repair \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC [(0.0001\). P)18(ain intensity on d)26(ays 1, )]TJ 0.028 Tw T* [(3, and 5 w)13(as low)12.1(er in the ne)10(w reconstruction )0.5(techniq)14(ue g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.005, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.002, p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.0007\). The freq)13.9(uency of )]TJ 0.001 Tw T* [(early com)16(plications w)13(as 16% in the ne)10(w techniq)14(ue g)14(roup v)13(ersus 32% and 24% in the com)16(par)-37(ison g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.17\). )Tj -0.018 Tw T* [(The dif)-39.9(ferences w)12(ere no)13(t statistically signif)-43(icant. W)28.9(ound suppuration dev)13(eloped in 2)]TJ /Span<>> BDC ( )Tj EMC (\(4%\) vs. 8)Tj /Span<>> BDC ( )Tj EMC (\(16%\) and 5)Tj /Span<>> BDC ( )Tj EMC (\(10%\), )Tj 0.061 Tw T* (p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.43. Late com)16.1(plications w)12(ere recorded in 2% of patients in the ne)10(w reconstruction g)14(roup v)13(ersus 14% in each )]TJ 0.079 Tw T* [(of the com)16(par)-37(ison g)14(roups \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.07\). The rate of chronic f)-43(istulas \(0, 2)]TJ /Span<>> BDC ( )Tj EMC (\(4%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.22\), per)-37(ineal her)-14(nia )]TJ 0.068 Tw T* (\(1)Tj /Span<>> BDC ( )Tj EMC (\(2%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), 3)Tj /Span<>> BDC ( )Tj EMC (\(6%\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.22\). Quality of life indicators w)12(ere signif)-43(icantly better in the ne)10(w reconstruction )]TJ 0.023 Tw T* [(g)14(roup \(p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0.0001\).)Tj 0.05 Tw 0 -1.111 TD [(C)21(ON)22(CLUSIONS: per)-36.9(ineal w)12(ound reconstruction using the ne)10(w techniq)14(ue af)-46(ter EL)-35.9(APE for rectal cancer req)14(uires more )]TJ 0.109 Tw 0 -1.111 TD [(time, but it p)46(rovides reduced postoperativ)13.1(e pain intensity)42.1(, im)16.1(p)46(rov)13(ed q)14(uality of life, and demonstrates a clinically )]TJ 0.023 Tw T* [(signif)-43(icant trend tow)13.1(ards reducing the freq)14(uency of early and late postoperativ)13(e com)16(plications.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 330.9398 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.074 Tw 4.948 0 Td [( )0.5(\027xtralev)16.1(ator )0.5(abdominoper)-36.9(ineal )0.6(e)-15(xcision, )0.6(rectal )0.5(cancer)61.1(, )0.5(reconstructiv)13.1(e )0.5(surg)12(er)-43(y)42(, )0.5(per)-36.9(ineal )0.5(w)12(ound, )0.6(postoperativ)13(e )0.6(com)16(plications, )0.6(q)14(uality )]TJ 0.023 Tw -4.953 -1.2 Td (of)Tj /Span<>> BDC ( )Tj EMC [(life, p)46(rediction, multicenter study)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.039 Tc -0.044 Tw -9.871 -2.617 Td [(F)3.3(O)-4.5(R)8.9( C)-17.3(I)-15.5(T)45.5(A)37.7(T)-24.4(I)-1.2(ON:)]TJ /T1_3 1 Tf 0.025 Tc -0.035 Tw 6.426 0 Td [( P)-0.8(o)-15.5(l)-20.8(o)-10.2(v)-51.6(i)-3.1(n)-8.7(k)-41(i)-3.1(n)]TJ /Span<>> BDC ( )Tj EMC [(V)39.8(.)40.7(V)39.8(.)-23.4(, S)-10.2(h)-13.8(i)-5.9(r)-30.7(a)-11.3(l)-16.6(i)-17.1(y)-20.4(e)-15.6(v)]TJ /Span<>> BDC ( )Tj EMC [(R)-21.3(.)-7.2(M)-7(.)12(-)-8.3(A)-22.8(.)-23.4(, K)-20.4(h)-8.2(a)-11.3(l)-37.7(a)-14.3(f)-67.5(y)-24.1(a)-7.5(n)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.9(.)-23.8(A)-22.9(.)-23.4(, K)-30.3(a)-8.9(u)-21.8(s)-8.7(h)-8.2(a)-7.5(n)-11.1(s)-11(k)-45.5(y)]TJ /Span<>> BDC ( )Tj EMC [(V)39.9(.)0.5(B)3.4(.)-23.4(, E)-1.8(r)-35.8(m)-8.2(a)-11(k)-3.6(o)-10.2(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.5(.)-23.8(A)-22.9(. R)-6.6(e)-19(c)-6.3(o)-9.1(n)-11.1(s)-29.2(t)-30.7(r)-30.2(u)-6.3(c)-41.4(t)-46.1(i)-6.7(o)-9.1(n o)-12(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-24.6(e)-12(r)-56.3(i)-3(n)-16(e)-12.9(a)-11.3(l w)-13.4(o)-13.2(u)-4.9(n)-14.4(d)25( )]TJ 0.033 Tc 0.029 Tw -6.431 -1.2 Td [(a)-7.6(n)-14.5(d p)-24.7(e)-18(l)-5.6(v)-51.7(i)-5(c f)-47(l)-20.9(o)-18.6(o)-11.8(r a)-14.4(f)-66.2(t)-24.7(e)-12.1(r e)-33.1(x)-44.7(t)-30.8(r)-30.8(a)-11.4(l)-23.7(e)-15.8(v)-28.3(a)-18.2(t)-21.9(o)-11.8(r a)-18.2(b)-22.1(d)-11.1(o)-9.2(m)-14.5(i)-3.2(n)-11.9(o)-8.3(p)-24.6(e)-12.1(r)-56.4(i)-3.2(n)-16.1(e)-13(a)-11.4(l e)-33.1(x)-5.4(c)-38.2(i)-7.4(s)-26.1(i)-6.8(o)-9.2(n o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15.1(e r)-19.1(e)-19.1(c)-41.5(t)-22.3(u)-7(m)4.5(: a)]TJ /Span<>> BDC ( )Tj EMC [(n)-11.8(o)-10.4(v)-18.6(e)-18(l s)-19.1(o)-15.6(l)-23.3(u)-16.3(t)-46.2(i)-6.7(o)-9.2(n t)-21.8(o)]TJ /Span<>> BDC ( )Tj EMC [(t)-26.1(h)-15(e p)-13.7(r)-15.7(o)-11.6(b)-18.2(l)-23.7(e)-11.5(m \()39.2(r)-19.1(e)-22.8(s)-8.7(u)-8.4(l)-15.4(t)-48.9(s o)-12.1(f)]TJ /Span<>> BDC ( )Tj EMC (a)Tj /Span<>> BDC ( )Tj EMC [(m)-8.1(u)-8.4(l)]TJ 0 Tc 0 Tw 56.341 0 Td (-)Tj 0.029 Tc -0.035 Tw -56.341 -1.2 Td [(t)-46.1(i)-4.9(c)-9.6(e)-11.5(n)-17.2(t)-24.6(e)-12(r r)-30.7(a)-7.5(n)-14.5(d)-11(o)-9.1(m)-14.4(i)-8.2(z)-13.9(e)-21(d s)-29.3(t)-22.2(u)-10.3(d)-20.4(y)19.7(\))10.5(. )]TJ /T1_1 1 Tf 0.039 Tc -0.039 Tw [(K)14(ol)3.7(op)2.5(r)3.2(o)3.4(k)-19.1(t)2.3(ol)3.7(o)-3.3(g)-13.1(i)6.8(a)5.9(.)]TJ /T1_3 1 Tf 0.029 Tc -0.035 Tw 19.571 0 Td [( 2)-8.8(0)-3.7(2)4.3(6)19.9(;)9.9(2)-1.3(5)1(\()37.8(1)44.3(\))14.6(:)-3.7(8)-1.4(1)26.5(\226)-5.2(91)4.3(. \()-0.8(i)-3.1(n R)-6.4(u)-21.8(s)-22.2(s)-15.5(.)43.3(\))10.5(. h)-17.1(t)-49.3(t)-29.3(p)-18.7(s)-7.9(:)2(/)84.8(/)36.5(d)-11(o)-12.5(i.)2.8(o)-11.7(r)-16.6(g)-22.7(/)11.2(1)14.1(0)6.6(.)-5.5(3)8(3)-15.9(8)1.4(7)4.7(8/)7.9(2)-8.8(0)9.4(7)-1.8(3)-13.2(-)41.3(7)10.7(5)0.5(5)-8.8(6)-26.6(-)9.7(2)-8.8(0)-3.7(2)4.3(6)-26.7(-)9.8(2)-1.3(5)-23.4(-)55.2(1)27(-)-25.2(8)-1.4(1)27(-)-4.1(91)]TJ /T1_2 1 Tf 0.017 Tc 0.345 Tw -19.566 -2.617 Td [(\026\020\021\033\030)4.9( \020\036\017)4.9( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0.007 Tc 0.35 Tw 11.372 0 Td [( \220\031\032\031\025\022\025 \001.\211., \216\221\210\207 \253\202\f\022\ \025\022\007\027\024\n\022\235 \031\025\n\031\f\031\b\022\007\027\024\n\022\ \235 )0.5(\030\022\024\033\020\025\024\027\032 \2421\273 \215\022\025\016\030\032\020\ \021\020 \202\032\020\024\025\031\030\020\032\024\n\031\b\031 \n\032\020\ \t,)7( )]TJ 0 Tc 0.023 Tw -11.377 -1.2 Td (\r\f.)Tj /Span<>> BDC ( )Tj EMC (\220\022\026\022\023\032\031\021\020, \030.)Tj /Span<>> BDC ( )Tj EMC (146, \202\032\020\024\025\031\030\020\032, 350040, \206\031\024\024\022\t\ ; \023\027\f.: +7)Tj /Span<>> BDC ( )Tj EMC (\(918\) 626-55-13; e-mail: nikolajdoronin23@mail.ru)Tj /T1_2 1 Tf 0.012 Tc 0.344 Tw 0.005 -1.2 Td [(ADDRESS)5.2( F)13.1(OR)5.1( C)19.1(ORRESPONDEN)23.2(CE:)]TJ /T1_1 1 Tf 0.002 Tc 0.349 Tw 14.754 0 Td [( Doronin N)28.2(.V)61.1(., Clinical Oncology Dispensar)-42.9(y N)17.1(o. 1, Dimitrov)16.2(a st., 146, Krasnod)26.1(ar)61.1(, 350040, R)22.1(ussia;)2( )584( )]TJ 0 Tc 0.023 Tw -14.759 -1.2 Td (tel.:)Tj /Span<>> BDC ( )Tj EMC (+7)Tj /Span<>> BDC ( )Tj EMC (\(918\))Tj /Span<>> BDC ( )Tj EMC [(626-55-13; e-mail: nik)13(ola)10.1(jdoronin23@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 23.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 23.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 23.10.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 23.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 140.2859 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0.282 Tw 10 0 0 10 70.8661 115.9299 Tm [(\230\f\021\024\030\017\016 \030\026\r\017\021\017\016 \b\017\030\031\030\ \020\017\004\036\f\022\017\b )0.5(\n\036\021\024\007\024\r \035\036\004\036\027\017\016 )]TJ 0.203 Tw 0 -1.218 TD (\035\024\022\026\004\036\f\021\r\036\027\027\t\b \024\023\031\b\024\035\ \036\005 \023\030\016\n\024\005 \022\017\001\022\017 \027\026\004\026\035\ \026\f\034 )Tj 0.194 Tw T* (\036\013\036 \f)Tj /Span<>> BDC ( )Tj EMC (\f\036\030\036\007\017\027\t XVIII \r\036\022\026, \027\024 \030\036\r\024\ \035\033\006\017\024\027\027\024\036 \f\024)Tj 0 Tw (-)Tj -0.004 Tw T* (\002\t\021\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \027\026\023\030\026\r\035\036\027\017\017 \023\030\024\017\ \024\001\035\024 \035\017\001\034 \r)Tj /Span<>> BDC ( )Tj EMC (1908)Tj /Span<>> BDC ( )Tj EMC (\020., )Tj -0.047 Tw 23.244 6.089 Td [(\022\024\020\007\026 W)-16(ill)-31(iam Er)-14.9(nest Miles, \024\f\027\024\r\t\r\026\016\f\034 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\023\024\027\017\n\026\027\017\017 )Tj 0.019 Tw T* (\030\026\f\023\030\024\f\021\030\026\027\036\027\017\016 \024\023\031\b\024\ \035\036\r\024\020\024 \023\030\024\006\036\f\f\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\035\017\n\235\026\021\017)Tj 0 Tw (-)Tj -0.035 Tw T* (\004\036\f\022\017\n \023\031\021\016\n, \023\030\036\007\035\024\032\017\ \035 \027\024\r\031\033 \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024\021 \023\036\030\017\024\007 \r\030\036\n\036)Tj 0 Tw (-)Tj 0.146 Tw T* (\027\017 \024\023\036\030\026\006\017\033)Tj /Span<>> BDC ( )Tj EMC (\227 \002\030\033\001\027\024-\023\030\024\n\036\032\027\024\f\021\027\031\ \033 \220\022\f\021\017\030\023\026)Tj 0 Tw (-)Tj -0.002 Tw T* (\006\017\033 \023\030\016\n\024\005 \022\017\001\022\017 \(\207\215\233 \ \215\025\). \233\021\026 \024\023\036\030\026\006\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\007\024\035\020\017\036 )Tj 0.144 Tw T* (\020\024\007\t \f\021\026\035\026 \024\f\027\024\r\027\t\n \030\026\007\017\ \022\026\035\034\027\t\n \r\n\036\001\026\021\036\035\034\f\021\r\024\n \ )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 544.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 73.5728 535.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1276 56.0378 Tm (82)Tj ET endstream endobj 1150 0 obj [1161 0 R] endobj 1151 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-9.9(\026\t\025\221 \005\017\t\217 \n\022\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 \224\025\016)-10(\020\004 )]TJ 0 -1 TD [(\237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-9.9(\026\t\025\221 \237\r\016)-10(\026\n\005\224\017\n\n )]TJ T* [(\224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\004 \005\004\204\004\ \t\n\004 \224\005\025\255\020\004\024\217 \(\005\004\212)21(\002\020\200)21(\026)11(\017\026\217 )]TJ T* [(\024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 \n\016\016)-9.9(\020\004\202\025\b\017\t\n\213\))]TJ 33.617 3 Td [(Reconstr)10(uction of\022perineal w)11.1(ound and pelvic floor af)-30.9(ter e)21(xtr)21(ale)11.1(v)9.9(ator )]TJ 4.064 -1 Td [(abdominoperineal e)21(x)21(cision of\022th)10.9(e r)31(ectum: a\022nov)12(el solution )]TJ 0.015 -1 Td [(to\022th)11(e pr)20.1(oblem \(r)31(esults of\022a\022multicenter r)21(andomiz)10(ed study\))]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 171.4105 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 171.4105 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 124.6027 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 124.6027 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-81-91)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 62.3798 695.3259 Tm [(\033\004\r)10(\025\t\016)-10(\026\005\002\r\n\213 \224\005\025\024\004\226\t\025\016)-10(\026\t\025\221 \005\017\t\217 \n\022)-23.3(\026)11(\017\212\025\b\025\013)10(\025 \202\t\017 )]TJ 0.436 -1.105 Td [(\224\025\016)-10(\020\004 \237\r\016)-10(\026\005\017\020\004\b\017\026)11(\025\005\t\025\221 \255\005\206\204\t\025-\224\005\025\024\004\226\t\025\ \016)-10(\026\t\025\221 )]TJ -0.938 -1.105 Td [(\237\r\016)-10(\026\n\005\224\017\n\n \224\005\213\024\025\221 \r\n\204\r\n: \t\025\b\025\ \004 \005\004\204\004\t\n\004 \224\005\025\255\020\004\024\217 )]TJ 0.594 -1.105 Td [(\(\005\004\212)21(\002\020\200)21.1(\026)10.9(\017\026\217 \024\t\025\013)10(\025\004\t\026\005\025\b\025\013)10.1(\025 \005\017\t\202\025\024\n\212\n\005\025\b\017\t\t\025\013)10(\025 )]TJ 0 Tw 7.775 -1.105 Td [(\n\016\016)-10(\020\004\202\025\b\017\t\n\213\))]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 586.822 Tm [(\034\025\020\025\b\n\t\r\n\t\022)-23.2(\021.\021.)]TJ 8.162 0 0 8.162 138.8981 591.484 Tm (2,3)Tj 0.023 Tw 14 0 0 14 150.7818 586.822 Tm [(, \201\025\005\025\t\n\t\022)-23.2(\007.\021.)]TJ 0 Tw 8.162 0 0 8.162 238.2888 591.484 Tm (1)Tj 0.023 Tw 14 0 0 14 242.9248 586.822 Tm [(, \222\n\005\017\020\n\004\b\022)-23.2(\033)124(.\235.-)-63(\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 359.1032 591.484 Tm (1)Tj 0.023 Tw 14 0 0 14 363.7392 586.822 Tm [(, \205\017\020\017\216\213\t\022)-23.2(\f)-31(.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 452.8979 591.484 Tm (4)Tj 14 0 0 14 457.5339 586.822 Tm (, )Tj -29.644 -1.143 Td [(\037)41(\017\002\204\017\t\016\r\n\221\022)-23.3(\021.\006.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 140.1448 575.484 Tm [(1,)-69(3)]TJ 0 Tc 0.023 Tw 14 0 0 14 151.4654 570.822 Tm [(, \240\005\024\017\r)10(\025\b\022)-23.2(\240.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 236.4105 575.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 556.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 553.1527 Tm [(\031\006)42(\227)31(\203 \253\037\020\n\t\n\225\004\016\r\n\221 \025\t\r)10(\025\020\025\013\n\225\004\016\r\n\221 \202\n\016\224\017\t\016\004\005 \ \0231\273 \235\n\t\212\202\005\017\b\017 \037)20(\005\017\016\t\025\202\017\005\016\r)10(\025\013)10(\025 \r\005\017\213 \(\002\020.\022)-23.3(\201\n\024\n\026\005\025\b\017, )]TJ -0.331 -1.2 Td [(\202.\022)-23.3(1)150(46, \013)62.1(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-32(, 3500)25(40, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 532.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 529.1527 Tm [(\031\006)42(\227)31(\203 \253\007\017\002\225\t\025-\n\016\016)-9.9(\020\004\202\025\b\017\026)11(\004\020\200\016\r\n\221 \n\t\016)-10(\026\n\026)-19.9(\002)-20(\026\022)-23.3(\230 \037)20(\005\017\004\b\017\213 \r)-9.9(\020\n\t\n\225\004\016\r\017\213 \255\025\020\200\t\n\017 \0231 \n\024.\ \022)-23.3(\224\005\025\216)-51.9(. )]TJ -0.331 -1.2 Td [(\001.\021.\022)-23.3(\036\225\017\224\025\b\016\r)10.1(\025\013)10(\025\273 \235\n\t\212\202\005\017\b\017 \037)20(\005\017\016\t\025\202\017\005\016\r)10(\025\013)10(\025 \r\005\017\213 \(\002\020.\022)-23.3(1 \235\017\213, \202.\022)-23.2(1)112(6)58(7)127(, \013)62(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-32(, 350086, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 508.4828 Tm (3)Tj 0.023 Tw 10 0 0 10 45.8311 505.1528 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\255\017\t\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020\ .\022)-23.3(\001\004\202\n\t\017, \202.\022)-23.2(4, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-32(, 350063, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 484.4828 Tm (4)Tj 0.023 Tw 10 0 0 10 45.8311 481.1529 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\255\017\t\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \002\t\n\b\004\005\016\n\026)11(\004\026\273 \(\002\020.\022)-23.2(\001\026)11(\017\b\005\025\224\025\020\200\016\r\017\213, \202.\022)-23.3(1)150(49, \013)62(.\022)-23.3(\037)20(\005\017\016\t\025\202\017\005)-31.9(, )]TJ -0.331 -1.2 Td [(3500)25(40, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0.021 Tw 9 0 0 9 90.7087 450.649 Tm [(\217\221\217\205\001\217\211\003\001\002\036: )0.6(\204\n\024\023\032\020\f\027\021\020\023\031\032\025\020\t )0.7(\240\032\005\213\025\031-\033\032\031\026\027\255\025\031\024\023\025\020\ \t )0.7(\204\n\024\023\022\032\033\020\006\022\t )0.5(\(\230\f\221\004\230\) )0.6(\033\032\t\026\031\235 )0.6(\n\022\213\n\022 )0.5(\024\031\033\032\t\255\027\025\020 )]TJ 0.023 Tw 0 -1.111 TD (\024)Tj /Span<>> BDC ( )Tj EMC (\203\031\032\026\022\032\031\021\020\025\022\027\026 \031\240\213\022\032\ \025\031\b\031 \030\027\203\027\n\023\020 \033\032\031\026\027\255\025\031\ \024\023\022, \033\032\022\021\031\030\t\212\027\b\031 \n)Tj /Span<>> BDC ( )Tj EMC (\021\013\024\031\n\031\235 \007\020\024\023\031\023\027 \031\024\f\031\255\ \025\027\025\022\235.)Tj 0.06 Tw T* (\037\036\035\034: \r\f\r\007\213\027\025\022\027 \032\027\016\r\f\017\023\ \020\023\031\021 \032\027\n\031\025\024\023\032\r\n\006\022\022 \033\032\ \031\026\027\255\025\031\024\023\025\031\235 \032\020\025\013 \033\031\024\ \f\027 \230\f\221\004\230 \033\032\t\026\031\235 \n\022\213\n\022 \033\031\ )Tj /Span<>> BDC ( )Tj EMC (\033\031\021\031\030\r )Tj 0.023 Tw T* (\032\020\n\020 \025\022\255\025\027\020\026\033\r\f\t\032\025\031\b\031 \ \031\023\030\027\f\020 \033\r\023\027\026 \033\032\022\026\027\025\027\025\ \022\t \025\031\021\031\b\031 \024\033\031\024\031\240\020 \033\f\020\024\ \023\022\n\022.)Tj 0.215 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\n\031\b\031\032\023\025\031\027 \026\025\031\b\031\006\027\025\023\032\031\ \021\031\027 \032\020\025\030\031\026\022\016\022\032\031\021\020\025\025\ \031\027 \n\031\025\023\032\031\f\022\032\r\027\026\031\027 \022\024\024\ \f\027\030\031\021\020\025\022\027 )Tj 0.249 Tw 0 -1.111 TD (\021\n\f\005\007\027\025\013 150 \033\020\006\022\027\025\023\031\021, \032\ \020\024\033\032\027\030\027\f\027\025\025\013\200 \021)Tj /Span<>> BDC ( )Tj EMC (\016\020\021\022\024\022\026\031\024\023\022 \031\023 \024\033\031\024\031\ \240\020 \033\f\020\024\023\022\n\022 \033\032\031\026\027\255\025\031\024\ \023\025\031\235 \032\020\025\013 )Tj 0.026 Tw 0 -1.111 TD (\021)Tj /Span<>> BDC ( )Tj EMC (\023\032\022 \b\032\r\033\033\013: \025\031\021\013\235 \024\033\031\024\ \031\240 \(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\), \033\032\031\024\023\031\027 \r\213\022\021\020\025\022\027 )0.5(\032\020\025\013 \(n)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(50\), \033\f\020\024\023\022\n\020 )0.5(\024\027\023\007\020\023\013\026 \204\025\030\031\033\032\031\023\027\016\ \031\026 )]TJ 0.044 Tw T* (\(n)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (50\). \002\016\r\007\020\f\022 \033\032\031\030\031\f\255\022\023\027\f\017\ \025\031\024\023\017 \204\023\020\033\020 \033\f\020\024\023\022\n\022, \ \n\032\031\021\031\033\031\023\027\032\005, \022\025\023\027\025\024\022\ \021\025\031\024\023\017 \240\031\f\027\021\031\b\031 \024\022\025\030\032\ \031\026\020, )Tj -0.004 Tw T* (\007\020\024\023\031\023\r \032\020\025\025\022\200 \(\030\031 30 \024\r\ \023\031\n\) \(\024\027\032\031\026\020, \b\027\026\020\023\031\026\020,\ \025\020\b\025\031\027\025\022\027, \025\027\n\032\031\016 \f\031\024\n\ \r\023\020\), \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\016\030\025\022\200 \(\026\027\030\022\020\025\020 14)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\t)Tj 0 Tw (-)Tj 0.05 Tw T* (\006\027\021\) \033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\ \013\200 \031\024\f\031\255\025\027\025\022\235 \(\024\021\022\212\022, \ \020\240\024\006\027\024\024\013, \033\032\031\026\027\255\025\031\024\023\ \025\013\027 \b\032\013\255\022, \200\032\031\025\022\007\027\024\n\022\235\ \240\031\f\027\021\031\235 \024\022\025\030)Tj 0 Tw (-)Tj 0.023 Tw T* (\032\031\026\), \031\006\027\025\022\021\020\f\022 \n\020\007\027\024\023\ \021\031 \255\022\016\025\022 \033\020\006\022\027\025\023\031\021.)Tj 0.194 Tw T* [(\206\036\207\210\035\034\003\201: )0.6(\033\032\031\030\031\f\255\022\023\027\f\017\025\031\024\023\017 )0.5(\204\023\020\033\020 )0.6(\033\f\020\024\023\022\n\022 )0.5(\240\031\f\017\213\027 )0.6(\021)]TJ /Span<>> BDC ( )Tj EMC 26.851 0 Td [(\b\032\r\033\033\027 )0.5(\025\031\021\031\b\031 )0.5(\024\033\031\024\031\240\020 )0.5(\(50 )0.6([45; )0.5(55] )0.5(\026\022\025.\) )]TJ 0.15 Tw -26.851 -1.111 Td (\033\032\031\023\022\021 20 [20; 25] \026\022\025. \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\024\023\031\026 \r\213\022\021\020\025\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (35 [30; 40] \026\022\025. \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\f\020\024\023\022\n\027 \024\027\023\n\031\235 \(p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\). )Tj 0.107 Tw T* (\002\025\023\027\025\024\022\021\025\031\024\023\017 \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020 \025\020)Tj /Span<>> BDC ( )Tj EMC (1, 3, 5-\027 \024\r\023\n\022 \025\022\255\027 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \025\031\021\031\b\031 \024\033\031\024\031\240\020\ \033\f\020\024\023\022\n\022 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,005, )Tj 0.076 Tw 0 -1.111 TD (\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002, \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0007\). \002\026\027\027\023 \026\027\024\023\031 \023\027\025\030\027\ \025\006\022\t \n)Tj /Span<>> BDC ( )Tj EMC (\024\025\022\255\027\025\022\005 \007\020\024\023\031\023\013 \032\020\025\ \025\022\200 \031\024\f\031\255\025\027\025\022\235 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \025\031\021\031\b\031 )Tj 0.001 Tw 0 -1.111 TD [(\024\033\031\024\031\240\020 )0.6(16% )0.5(\033\032\031\023\022\021 )0.6(32% )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 11.549 0 Td [(24% )0.6(\021)]TJ /Span<>> BDC ( )Tj EMC 2.692 0 Td [(\b\032\r\033\033\020\200 )0.6(\024\032\020\021\025\027\025\022\t )0.6(\(p)]TJ /Span<>> BDC ( )Tj EMC 9.027 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.733 0 Td [(0,17\). )0.6(\020\n\255\027 )0.5(\031\023\026\027\007\027\025 )0.6(\023\032\027\025\030 )0.5(\n)]TJ /Span<>> BDC ( )Tj EMC 12.775 0 Td [(\r\026\027\025\017\213\027\025\022\005 )0.6(\007\020\024\023\031)]TJ 0 Tw (-)Tj 0.007 Tw -36.777 -1.111 Td (\023\013 \033\031\016\030\025\022\200 \031\024\f\031\255\025\027\025\022\ \235 \r)Tj /Span<>> BDC ( )Tj EMC (2% \033\020\006\022\027\025\023\031\021 \b\032\r\033\033\013 \025\031\021\ \031\235 \033\f\020\024\023\022\n\022 \033\032\031\023\022\021 14%)Tj /Span<>> BDC ( )Tj EMC (\227 \021)Tj /Span<>> BDC ( )Tj EMC (\n\020\255\030\031\235 \022\016)Tj /Span<>> BDC ( )Tj EMC (\024\032\020\021\025\022\021\020\027\026\013\200 )Tj 0.004 Tw T* (\b\032\r\033\033 \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,07\), \021\n\f\005\007\020\t \032\020\016\021\022\023\022\027 \200\032\ \031\025\022\007\027\024\n\022\200 \024\021\022\212\027\235 \(0, 2)Tj /Span<>> BDC ( )Tj EMC (\(4%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,22\), \033\032\031\026\027\255\025\031\024\023\025\031\235 \b\032\013\255\ \022 )Tj 0.116 Tw T* (\(1)Tj /Span<>> BDC ( )Tj EMC (\(2%\), 4)Tj /Span<>> BDC ( )Tj EMC (\(8%\), 3)Tj /Span<>> BDC ( )Tj EMC (\(6%\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,22\), \200\032\031\025\022\007\027\024\n\031\b\031 \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020 \(2)Tj /Span<>> BDC ( )Tj EMC (\(4%\), 6)Tj /Span<>> BDC ( )Tj EMC (\(12%\), 3)Tj /Span<>> BDC ( )Tj EMC (\(6%\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,28\). )Tj 0.023 Tw T* (\004\031\n\020\016\020\023\027\f\022 \n\020\007\027\024\023\021\020 \255\ \022\016\025\022 \016\025\020\007\022\026\031 \f\r\007\213\027 \021)Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \025\031\021\031\235 \033\f\020\024\023\022\n\022 \(\ p)Tj /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,0001\).)Tj 0.05 Tw T* [(\211\201\211\217\220\201: )0.5(\030\f\t )0.6(\021\013\033\031\f\025\027\025\022\t )0.6(\033\f\020\024\023\022\n\022 )0.5(\033\032\031\026\027\255\025\031\024\023\025\031\235 )0.6(\032\020\025\013 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 25.611 0 Td [(\033\032\022\026\027\025\027\025\022\027\026 )0.5(\025\031\021\031\b\031 )0.5(\024\033\031\024\031\240\020 )0.5(\033\031\024\f\027 )0.5(\230\f\221\004\230 )0.5(\033\032\t)]TJ 0 Tw (-)Tj 0.029 Tw -25.611 -1.111 Td (\026\031\235 \n\022\213\n\022 \023\032\027\240\r\027\023\024\t \240\031\f\ \017\213\027 \021\032\027\026\027\025\022, \025\031 \031\025\020 \031\240\ \027\024\033\027\007\022\021\020\027\023 \024\025\022\255\027\025\022\027\ \022\025\023\027\025\024\022\021\025\031\024\023\022 \033\031\024\f\027\ \031\033\027\032\020\006\022\031\025\025\031\235 )Tj 0.031 Tw T* (\240\031\f\022, \r\f\r\007\213\027\025\022\027 \n\020\007\027\024\023\021\ \020 \255\022\016\025\022 \022)Tj /Span<>> BDC ( )Tj EMC (\030\027\026\031\025\024\023\032\022\032\r\027\023 \n\f\022\025\022\007\027\ \024\n\022 \016\025\020\007\022\026\r\005 \023\027\025\030\027\025\006\022\ \005 \n)Tj /Span<>> BDC ( )Tj EMC (\024\025\022\255\027\025\022\005 \007\020\024\023\031\023\013 )Tj 0.023 Tw 0 -1.111 TD (\032\020\025\025\022\200 \022)Tj /Span<>> BDC ( )Tj EMC (\033\031\016\030\025\022\200 \033\031\024\f\027\031\033\027\032\020\006\022\ \031\025\025\013\200 \031\024\f\031\255\025\027\025\022\235.)Tj /T1_2 1 Tf 0.01 Tc 0.133 Tw 8 0 0 8 42.5596 205.3797 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.138 Tw 8.608 0 Td ( \204\n\024\023\032\020\f\027\021\020\023\031\032\025\020\t \240\032\005\ \213\025\031-\033\032\031\026\027\255\025\031\024\023\025\020\t \204\n\024\ \023\022\032\033\020\006\022\t, \032\020\n \033\032\t\026\031\235 \n\022\ \213\n\022, \032\027\n\031\025\024\023\032\r\n\023\022\021\025\020\t \200\ \022\032\r\032\b\022\t, \033\032\031)Tj 0 Tw (-)Tj 0.023 Tw -8.613 -1.2 Td (\026\027\255\025\031\024\023\025\020\t \032\020\025\020, \033\031\024\f\027\ \031\033\027\032\020\006\022\031\025\025\013\027 \031\024\f\031\255\025\027\ \025\022\t, \n\020\007\027\024\023\021\031 \255\022\016\025\022, \033\032\ \031\b\025\031\016\022\032\031\021\020\025\022\027, \026\025\031\b\031\006\ \027\025\023\032\031\021\031\027 \022\024\024\f\027\030\031\021\020\025\022\ \027)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.025 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)4.8( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.015 Tc -0.035 Tw 9.004 0 Td ( \215\024\035\024\r\017\027\022\017\027)Tj /Span<>> BDC ( )Tj EMC (\200.\200., \212\024\030\024\027\017\027)Tj /Span<>> BDC ( )Tj EMC (\203.\200., \231\017\030\026\035\017\036\r)Tj /Span<>> BDC ( )Tj EMC (\217.\204.-\202., \216\026\035\026\235\016\027)Tj /Span<>> BDC ( )Tj EMC (\202.\202., \025\026\031\001\026\027\f\022\017\005)Tj /Span<>> BDC ( )Tj EMC (\200.\207., \213\030\n\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC [(\213.\202. \217\036\022\024\027\f\021\030\031\022\006\017\016)15( )]TJ 0.023 Tc 0.06 Tw -9.009 -1.2 Td (\023\030\024\n\036\032\027\024\f\021\027\024\005 \030\026\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\021\026\024\r\024\020\024 \007\027\026 \023\024\f\035\036 \220\022\f\021\ \030\026\035\036\r\026\021\024\030\027\024\005 \002\030\033\001\027\024-\ \023\030\024\n\036\032\027\024\f\021\027\024\005 \220\022\f\021\017\030\023\ \026\006\017\017 \023\030\016\n\024\005 \022\017\001\022\017: \027\024\r\ \024\036 \030\036\001\036)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.067 Tw 0 -1.2 TD [(\027\017\036 )0.5(\023\030\024\002\035\036\n\t )0.6(\(\030\036\031\035\034\021\026\021\t )0.5(\n\027\024\020\024\006\036\027\021\030\024\r\024\020\024 )0.5(\030\026\027\007\024\n\017\017\030\024\r\026\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016\). )]TJ /T1_1 1 Tf -0.023 Tw 36.574 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.067 Tw [( )0.5(2026; )0.5(\021.)]TJ /Span<>> BDC ( )Tj EMC 12.232 0 Td [(25, )0.5(\223)]TJ /Span<>> BDC ( )Tj EMC 2.762 0 Td [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC 2.156 0 Td [(81\22691.)23( )]TJ -0.023 Tw -53.724 -1.2 Td (https://doi.org/10.33878/2073-7556-2026-25-1-81-91)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 459.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 47.6607 450.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0145 56.0378 Tm (81)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 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ORCID 0000-0003-22\ 94-7169)Tj 0.122 Tw T* (\207\017\030\033\022\024\r \210\035\036\020 \204\017\b\026\005\035\024\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \f\021\026\030\001\017\005 \027\026\031\004)Tj 0 Tw (-)Tj 0.238 Tw T* (\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\036\027\ \017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.318 Tw 0 -1.218 TD (\027\024\005 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\ \205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024)Tj 0 Tw (-)Tj 0.251 Tw 0 -1.218 TD (\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0002-1081-1793)Tj 0.471 Tw T* [(\215\036\030\001\017\027\026 )0.5(\202\027\026\f\021\026\f\017\016 )0.6(\213\r\020\036\027\034\036\r\027\026)]TJ /Span<>> BDC ( )Tj EMC 14.737 0 Td [(\227 )0.5(\r\030\026\004 )0.5(\031\035\034\021\030\026)]TJ 0 Tw (-)Tj 0.931 Tw -14.737 -1.218 Td (\r\031\022\024\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \024\ \021\007\036\035\036\027\017\016 \031\035\034\021\030\026\r\031\022\024\ )Tj 0 Tw (-)Tj 0.561 Tw T* (\r\024\005 \007\017\026\020\027\024\f\021\017\022\017 \205\206\207\211 \253\ \203\204\230\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\ \017 )Tj 0.629 Tw T* (\017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0000-0002-4884-876X)Tj 0.127 Tw 23.244 23.138 Td (\204\031\007\030\024\r \202\027\007\030\036\005 \202\027\026\021\024\035\ \034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \r\036\007\031\013\017\005 \027\026)Tj 0 Tw (-)Tj 0.121 Tw T* (\031\004\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\ \026 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 )Tj 0.66 Tw T* (\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\ \211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\024\035\024\ \020\017\017 )Tj 0.223 Tw T* [(\017\n\036\027\017 )0.5(\202.\203.)]TJ /Span<>> BDC ( )Tj EMC 5.253 0 Td [(\217\t\032\017\b\273 )0.6(\204\017\027\007\030\026\r\026 )0.5(\217\024\f\f\017\017; )0.6(\023\030\024\235\036\f\f\024\030 )]TJ 0.172 Tw -5.253 -1.218 Td [(\022\026\235\036\007\030\t \022\024\035\024\023\030\024\022\021\024\035\024\ \020\017\017 )0.5(\205\206\207\210\211 \212\215\210 \253\217\024\f\f\017\005\f\022\026\016\ )]TJ 0.427 Tw T* [(\n\036\007\017\006\017\027\f\022\026\016 )0.6(\026\022\026\007\036\n\017\016 )0.5(\027\036\023\030\036\030\t\r\027\024\020\024 )0.6(\023\030\024\235\036\f\f\017\024)]TJ 0 Tw (-)Tj 0.34 Tw 0 -1.218 TD (\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026\027\017\016\ \273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID )Tj 0 Tw 0 -1.218 TD (0000-0002-1207-5988)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(T)35(imur V. Nik)-15.9(ishin)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6991-1716)Tj T* [(Iv)-15(an V. K)25.1(ost)15(ar)-24(ev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1778-0571)Tj 0 -1.218 TD [(Ale)-18(x)-10.9(ander Y)35(u. T)35(i)-24(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1636-8075)Tj 0 -1.218 TD [(Mar)-37(ia A. Igna)15.1(tenko)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0005-1182-419X)Tj 0 -1.218 TD [(Ev)-21(geny E. Zhar)-23.9(kov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-3403-9731)Tj T* [(Ikr)-32(omzhon I. Dad)42.1(ashev)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-2294-7169)Tj T* [(Oleg M. Bir)-23.9(yukov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1081-1793)Tj T* [(P)30(er)-10(shina E. Anast)15.1(asia)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-4884-876X)Tj T* [(Andr)-24(e)-10.9(y A. Mudr)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-1207-5988)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 456.9139 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.197 Tw 8 0 0 8 42.5197 444.0792 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(v)-15(an )0.5(Oostend)-16(or)-24(p)]TJ /Span<>> BDC ( )Tj EMC [(JY, )0.5(V)30(er)-24(k)-17(ade)]TJ /Span<>> BDC ( )Tj EMC 12.086 0 Td [(C, Han-Geur)-21.9(ts)]TJ /Span<>> BDC ( )Tj EMC 6.056 0 Td [(IJM, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. )0.5(L)-32(iga)15(t)-32(ion )]TJ 0.092 Tw -19.438 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(inter)-10(sphinc)-16(ter)-36.9(ic f)-28(istul)-15.9(a tr)-32.9(a)-17(c)-16(t \(LIFT\) for tr)-32.9(ans-sphinc)-16(ter)-36.9(ic cr)-24(ypt)17.1(o)]TJ 0 Tw (-)Tj 0.117 Tw 0 -1.25 TD [(gl)-16(andul)-15.9(ar anal f)-28(istul)-15.9(a: l)30(ong-ter)-16(m im)10(p)32(a)-17(c)-16(t on f)16(aecal cont)-32(inence. )]TJ /T1_4 1 Tf 0 Tw (BJS )Tj T* (Open.)Tj /T1_1 1 Tf 0.023 Tw [( 2024;8\(3\):zr)-32.9(ae025. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1093/bjsopen/zr)-33(ae025)]TJ 0 0 0 1 k /GS1 gs -0.019 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Madboul)35(y)]TJ /Span<>> BDC ( )Tj EMC [(KM, El S)-16(ha)-24(zl)35(y)]TJ /Span<>> BDC ( )Tj EMC [(W, A)-14(bbas)]TJ /Span<>> BDC ( )Tj EMC [(K)-25(S, e)-12(t al. L)-32(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(inter)-9.9(sphinc)]TJ 0 Tw (-)Tj 0.041 Tw -1.296 -1.25 Td [(ter)-37(ic f)-28(istul)-15.9(a tr)-33(a)-17(c)-16(t ver)-10(sus mucosal ad)-17(v)-15(ancement fl)-16(ap in p)32(a)15(t)-32(ients wi)-24(t)-13(h )]TJ 0.008 Tc 0.349 Tw T* [(high tr)-32.7(anssphinc)-15.7(ter)-36.7(ic f)-27.7(istul)-15.7(a-in-ano: a)]TJ /Span<>> BDC ( )Tj EMC [(p)25.3(r)-31.7(ospec)-15.7(t)-31.7(i)-15.7(ve r)-32.7(and)-15.7(omized)8( )]TJ 0 Tc 0 Tw T* [(tr)-37(ial. )]TJ /T1_4 1 Tf 0.085 Tw 2.319 0 Td [(Dis Colon R)21(ectum.)]TJ /T1_1 1 Tf [( 2014 O)-16(c)-16(t;57\(10\):1202\2261208. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.319 -1.25 Td (DCR.0000000000000194)Tj 0 0 0 1 k /GS1 gs 0.103 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Zhang)Tj /Span<>> BDC ( )Tj EMC (L, Zhan)Tj /Span<>> BDC ( )Tj EMC [(C, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(L, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(iga)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he inter)-10(sphinc)-15.9(ter)-37(ic f)-28(is)]TJ 0 Tw (-)Tj 0.092 Tw -1.296 -1.25 Td [(tul)-16(a tr)-33(a)-17(c)-16(t \(LIFT\) for high tr)-32.9(anssphinc)-16(ter)-37(ic f)-28(istul)-16(as: a)]TJ /Span<>> BDC ( )Tj EMC [(d)-16(ouble-center )]TJ 0.047 Tw T* [(r)-24(e)-12(tr)-31.9(ospec)-16(t)-32(i)-16(ve stud)17(y wi)-24(t)-13(h l)30(ong-ter)-16(m foll)30(o)-14(w-up. )]TJ /T1_4 1 Tf [(Ann Colop)46.1(roctol.)]TJ /T1_1 1 Tf ( 2025 )Tj 0.023 Tw T* [(F)10(eb;41\(1\):77\22683. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3393/a)-17(c.2024.00024.0003)]TJ 0 0 0 1 k /GS1 gs 0.033 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (Chase)Tj /Span<>> BDC ( )Tj EMC [(T)25(JG, Q)-16(uddus)]TJ /Span<>> BDC ( )Tj EMC [(A, Sel)30(v)-15(akumar)]TJ /Span<>> BDC ( )Tj EMC [(D, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)37(AAFT for com)10(ple)-18(x anal )]TJ -0.012 Tw -1.296 -1.25 Td [(f)-28(istul)-15.9(a: a)]TJ /Span<>> BDC ( )Tj EMC [(useful t)17(o)-16(ol, ho)-14(wever, cur)-23.9(e is unl)-31(ik)10(el)35(y. )]TJ /T1_4 1 Tf [(T)54(ech Colop)46(roctol)]TJ /T1_1 1 Tf (. 2021 )Tj 0.023 Tw T* [(O)-16(c)-16(t;25\(10\):1115\2261121. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-021-02486-9)Tj 0 0 0 1 k /GS1 gs -0.006 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(L)-32(a T)45(or)-24(r)-23.9(e)]TJ /Span<>> BDC ( )Tj EMC [(M, Go)-16(gl)-31(ia)]TJ /Span<>> BDC ( )Tj EMC [(M, Micar)-24(ell)-30.9(i)]TJ /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)35.1(ong ter)-16(m r)-24(esul)56.1(ts of)]TJ /Span<>> BDC ( )Tj EMC [(v)-16(ideo\226)]TJ 0.302 Tw -1.296 -1.25 Td [(assisted anal f)-28(istul)-15.9(a tr)-23.9(ea)15(tment for com)10(ple)-18(x anal f)-28(istul)-16(a: ano)17(t)-13(h)]TJ 0 Tw (-)Tj 0.294 Tw T* [(er sha)15(t)-30(ter)-24(ed dr)-24(eam? )]TJ /T1_4 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf [( 2023 O)-16(c)-16(t;25\(10\):2017\2262023. )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1111/codi.16662)Tj 0 0 0 1 k /GS1 gs 0.076 Tw -1.847 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(de )0.5(l)-16(a )0.5(P)10(or)-22(t)-32(ill)-15.9(a)]TJ /Span<>> BDC ( )Tj EMC 5.628 0 Td [(F, )0.5(Mu\361oz-Cr)-22(uzad)-15.9(o)]TJ /Span<>> BDC ( )Tj EMC 7.423 0 Td [(MVD, )0.5(Maestr)-24(e)]TJ /Span<>> BDC ( )Tj EMC 5.669 0 Td [(MV, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.8 0 Td [(al. )0.5(Pl)-16(a)15(tele)-11.9(t-)]TJ 0.09 Tw -22.816 -1.25 Td [(r)-37(ich pl)-16(as)26(ma \(PRP\) ver)-9.9(sus f)-27.9(ibr)-37(in gl)35(ue in cr)-24(ypt)17(o)-16(genic f)-28(istul)-16(a\226in\226ano: )]TJ 0.302 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC 0.998 0 Td [(phase )0.5(III )0.5(single-center, )0.6(r)-33(and)-16(omized, )0.5(d)-16(ouble\226bl)-30.9(ind )0.5(tr)-37(ial. )]TJ /T1_4 1 Tf 24.498 0 Td [(Int )0.5(J )]TJ 0.276 Tw -25.495 -1.25 Td [(Colorectal )0.5(Dis)]TJ /T1_1 1 Tf [(. 2019 Jun;34\(6\):1113\2261119. )0.5(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s00384-)Tj T* (019-03296-0)Tj 0 0 0 1 k /GS1 gs 0.159 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\205\030\024\035\024\r)Tj /Span<>> BDC ( )Tj EMC 3.476 0 Td [(\222.\202., )0.5(\025\031\034\n\017\027\024\r)]TJ /Span<>> BDC ( )Tj EMC 7.026 0 Td [(\202.\204., )0.5(\025\024\030\024\035\017\022)]TJ /Span<>> BDC ( )Tj EMC 6.296 0 Td [(\200.\224., )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 3.424 0 Td [(\f\024\026\r\021. )0.5(\215\036\030\r\t\005 )]TJ 0.322 Tw -21.518 -1.25 Td [(\024\023\t\021 \007\r\031\b\220\021\026\023\027\024\020\024 \035\036\004\ \036\027\017\016 )0.5(\021\030\026\027\f\f\235\017\027\022\021\036\030\027\t\b )0.5(\f\r\017\013\036\005 \023\030\016\n\024\005 )]TJ -0.006 Tw T* (\022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \235\017\002\030\017\027\024\r\024\020\024 \022\035\ \036\016. )Tj /T1_4 1 Tf (\206\031\024\024\022\235\024\n\022\235 \255\r\032\025\020\f \b\020\024\023\ \032\031)Tj 0 Tw (-)Tj 0.002 Tc 0.35 Tw T* (\204\025\023\027\032\031\f\031\b\022\022, \b\027\033\020\023\031\f\031\b\ \022\022, \n\031\f\031\033\032\031\n\023\031\f\031\b\022\022. )Tj /T1_1 1 Tf -0.002 Tw (2017;27\(4\):102\226)Tj 0 Tc 0.312 Tw T* [(107. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-4376-2017-27-4-102-107)Tj 0 0 0 1 k /GS1 gs 0.312 Tw [( / F)10(r)-32(ol)30(ov)]TJ /Span<>> BDC ( )Tj EMC (S.A., )Tj 0.01 Tw T* [(K)25(uzminov)]TJ /Span<>> BDC ( )Tj EMC [(A.M., K)25(or)-32(ol)-30.9(ik)]TJ /Span<>> BDC ( )Tj EMC [(V.Y)35(u., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. T)47(he)]TJ /Span<>> BDC ( )Tj EMC [(f)-28(ir)-9.9(st e)-18(xper)-37(ience of)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(w)-14(o-st)15(a)-17(ge )]TJ 0.042 Tw T* [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-33(anssphinc)-16(ter)-36.9(ic f)-28(istul)-15.9(as of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he r)-24(ec)-16(tum sing f)-28(ibr)-37(ingl)35(ue. )]TJ /T1_4 1 Tf 0.166 Tw T* [(R)19(os Zh Gastroenterol Gepatol K)18(olop)46(roktol)]TJ /T1_1 1 Tf (. 2017;27\(4\):102\226107. \(In )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.22416/1382-4376-2017-27-4-102-107)Tj 0 0 0 1 k /GS1 gs 0.161 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(Her)-24(r)-23.9(er)-32(os)]TJ /Span<>> BDC ( )Tj EMC [(MD, Gar)-32(c)-24(ia-Ar)-23.9(r)-33(anz)]TJ /Span<>> BDC ( )Tj EMC [(M, Guad)42(al)-16(ajar)-32.9(a)]TJ /Span<>> BDC ( )Tj EMC [(H, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. A)10(ut)17(ol)30(o)-16(gous )]TJ 0.107 Tw -1.296 -1.25 Td [(e)-18(xp)32(anded adipose\226der)-37(i)-16(ved stem cells for t)-13(he)]TJ /Span<>> BDC ( )Tj EMC [(tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(ple)-17.9(x )]TJ 0.197 Tw T* [(cr)-24(ypt)17.1(o)-16(gl)-16(andul)-16(ar per)-37(ianal f)-28(istul)-15.9(as: a)]TJ /Span<>> BDC ( )Tj EMC [(phase III r)-33(and)-16(omized cl)-31(inical )]TJ 0.051 Tw 29.055 45 Td [(tr)-37(ial \(F)24(A)15(TT 1: f)-28(istul)-15.9(a ad)-17.1(v)-14.9(anced t)-13(her)-33(apy tr)-37(ial 1\) and l)30(ong-ter)-16(m ev)-15(al)35(u)]TJ 0 Tw (-)Tj T* [(a)15(t)-32(ion. )]TJ /T1_4 1 Tf 0.26 Tw 2.919 0 Td [(Dis Colon R)21(ectum)]TJ /T1_1 1 Tf [(. 2012 Jul;55\(7\):762\226772. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1097/)Tj -2.919 -1.25 Td (DCR.0b013e318255364a)Tj 0 0 0 1 k /GS1 gs 0.222 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\231\026\b\030\026\005)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \206\026\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\204., \206\026\017\027)Tj /Span<>> BDC ( )Tj EMC (\204.\224. \233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036\ \024\002\024)Tj 0 Tw (-)Tj 0.17 Tw -1.296 -1.25 Td (\f\027\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\005 \022\035\017\027\017\004\036\f\022\017\005 \024\023\ \t\021 \021\030\026\027\f\023\035\026\027\021\026\006\017\017 \022\031\035\ \034\021\031\030\t )Tj 0.162 Tw T* (\026\031\021\024\035\024\020\017\004\027\t\b \n\036\036\027\b\017\n\026\ \035\034\027\t\b \f\021\r\024\035\024\r\t\b \022\035\036\021\024\022 \032\ \017\030\024\r\024\005 \021\022\026\027\017 )Tj 0.161 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.868 0 Td [(\022\024\n\023\035\036\022\f\027\024\n )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\n )0.6(\035\036\004\036\027\017\017 )0.5(\220\022\f\021\030\026- )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 20.61 0 Td (\004\030\036\f\235\017\027\022\021\036\030)Tj 0 Tw (-)Tj 0.05 Tw -21.478 -1.25 Td (\027\t\b \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017\ . )Tj /T1_4 1 Tf (\001\031\021\031\024\023\022 \200\022\032\r\032\b\022\022. )Tj /T1_1 1 Tf 0 Tw (2012;20\(6\):60\22669. )Tj -0.018 Tw T* [(/ S)-16(hakhr)-33(ai)]TJ /Span<>> BDC ( )Tj EMC [(S.V., Gain Y)35(u.M., Gain)]TJ /Span<>> BDC ( )Tj EMC [(M.Y)35.1(u. E)35(xper)-37(iment)15(al just)-32(if)-28(ica)15(t)-32(ion and )]TJ 0.079 Tw T* [(f)-28(ir)-10(st cl)-31(inical e)-18(xper)-37(ience of)]TJ /Span<>> BDC ( )Tj EMC [(tr)-33(anspl)-16(ant)15(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(cul)56.1(tur)-24(e of)]TJ /Span<>> BDC ( )Tj EMC [(aut)17(ol)30(o)-16(gical )]TJ 0.183 Tw T* [(adipose t)-32(issue mesenchymal stem cells in com)10(ple)-17.9(x sur)-32(gical tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.006 Tw T* (ment of)Tj /Span<>> BDC ( )Tj EMC [(e)-18(xtr)-32.9(a- and tr)-33(ans-sphinc)-16(ter r)-24(ec)-16(tum f)-28(istul)-15.9(as. )]TJ /T1_4 1 Tf [(N)17(ov)13(osti Khirurgii.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* (2012;20\(6\):60\22669. \(In Russ.\).)Tj 0.015 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Or)-22(t)-32(iz)]TJ /Span<>> BDC ( )Tj EMC [(H, Mar)-24(zo)]TJ /Span<>> BDC ( )Tj EMC (J, Ciga)Tj /Span<>> BDC ( )Tj EMC [(MA, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)-10(and)-16(omized cl)-30.9(inical tr)-37(ial of)]TJ /Span<>> BDC ( )Tj EMC (anal )Tj 0.001 Tc 0.349 Tw -1.796 -1.25 Td [(f)-27.5(is)0.5(t)0.5(ul)-15.5(a)0.5( pl)35.5(u)0.5(g v)0.5(er)-9.5(s)0.5(us)0.5( e)0.5(nd)-15.5(o)0.5(r)-23.6(e)0.5(c)-15.5(t)15.4(a)0.5(l)0.5( ad)-16.5(v)-14.5(an)0.5(ce)0.5(me)0.5(n)0.5(t f)0.5(l)-15.5(ap)0.5( f)0.5(or)0.5( t)-12.5(he)]TJ /Span<>> BDC 24.742 0 Td ( )Tj EMC [(t)0.5(r)-23.6(e)0.5(a)15.5(t)]TJ 0 Tc 0 Tw (-)Tj 0.003 Tc 0.35 Tw -24.742 -1.25 Td (ment of)Tj /Span<>> BDC ( )Tj EMC [(high cr)-24.2(ypt)16.8(o)-16.2(gl)-16.3(andul)-16.2(ar f)-28.2(istul)-16.2(a in ano. )]TJ /T1_4 1 Tf (Br J Surg.)Tj /T1_1 1 Tf [( 2009)3( )]TJ 0 Tc 0.023 Tw T* [(Ma)15(y;96\(5\):608\226612. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1002/bjs.6613)Tj 0 0 0 1 k /GS1 gs 0.155 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Zhang)Tj /Span<>> BDC ( )Tj EMC [(Y, L)-32(i)]TJ /Span<>> BDC ( )Tj EMC (F, Zhao)Tj /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. V)-15(ideo\226assisted anal f)-28(istul)-15.9(a tr)-23.9(ea)15(t)]TJ 0 Tw (-)Tj 0.182 Tw -1.796 -1.25 Td [(ment combined wi)-23.9(t)-13(h anal f)-28(istul)-15.9(a pl)35(ug for tr)-24(ea)15(tment of)]TJ /Span<>> BDC ( )Tj EMC [(hor)-10(seshoe )]TJ 0.001 Tc 0.35 Tw T* [(anal f)-28.3(istul)-16.2(a. )]TJ /T1_4 1 Tf [(J Int Med R)20.7(es.)]TJ /T1_1 1 Tf [( 2021 Jan;49\(1\):300060520980525.)1( )]TJ 0 Tc 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1177/0300060520980525)Tj 0 0 0 1 k /GS1 gs 0.123 Tw -1.847 -1.25 Td (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(G)20(r)-32(ossber)-31.9(g)]TJ /Span<>> BDC ( )Tj EMC [(SJ, Har)-24(r)-32.9(an)]TJ /Span<>> BDC ( )Tj EMC [(N, Bebing)17.1(t)17(on)]TJ /Span<>> BDC ( )Tj EMC [(B, e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC (al. Use of)Tj /Span<>> BDC ( )Tj EMC [(t)-13(he OVESC)13(O )]TJ 0.125 Tw -1.796 -1.25 Td [(OT)25(SC\256 p)25(r)-31.9(o)-16(c)-16(t)17(ol)30(o)-16(g)16(y cl)-30.9(ip for cl)30(osur)-23.9(e of)]TJ /Span<>> BDC ( )Tj EMC 15.193 0 Td [(f)-28(istul)-16(a\226in\226ano a)15(t )0.5(W)-16(i)-24(ts Donald )]TJ 0.109 Tw -15.193 -1.25 Td [(Gor)-24(d)-16(on Medical Centr)-24(e)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC [(single centr)-24(e e)-18(xper)-37(ience. )]TJ /T1_4 1 Tf (S Afr J Surg.)Tj /T1_1 1 Tf 0 Tw ( )Tj T* (2020;58\(2\):74\22677.)Tj 0.35 Tw T* (13.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(P)35(r)-32(osst)]TJ /Span<>> BDC ( )Tj EMC 3.036 0 Td [(RL, )0.6(Jo)-16(os)]TJ /Span<>> BDC ( )Tj EMC 4.177 0 Td [(AK, )0.6(Ehni)]TJ /Span<>> BDC ( )Tj EMC 4.222 0 Td [(W, )0.5(e)-12(t)]TJ /Span<>> BDC ( )Tj EMC 2.885 0 Td [(al. )0.5(P)34.9(r)-32(ospec)-16.1(t)-32(i)-16(ve )0.5(pil)29.9(o)17(t )0.5(stud)16.9(y )]TJ 0.045 Tw -16.116 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC [(anor)-24(ec)-16(t)15.1(al f)-27.9(istul)-16(a cl)30(osur)-24(e wi)-23.9(t)-13(h t)-12.9(he)]TJ /Span<>> BDC ( )Tj EMC [(OT)25(SC P)35(r)-31.9(o)-16(c)-16(t)17(ol)30(o)-16(g)16(y. )]TJ /T1_4 1 Tf (Colorectal Dis.)Tj /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2014;17:81\22686. d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1111/codi.12762)Tj 0 0 0 1 k /GS1 gs 0.13 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(N)-14(or)-24(dholm-Car)-9.9(stensen)]TJ /Span<>> BDC ( )Tj EMC [(A, P)30(er)-24(r)-24(egaar)-23.9(d)]TJ /Span<>> BDC ( )Tj EMC [(H, Ha)-17(gen)]TJ /Span<>> BDC ( )Tj EMC [(KB, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. F)-19(istul)-16(a )]TJ 0.163 Tw -1.796 -1.25 Td [(l)-16(aser cl)30(osur)-24(e \(F)-19(iL)-32(aC\252\) for f)-28(istul)-16(a-in-ano)]TJ /Span<>> BDC ( )Tj EMC [(\227 ye)-12(t ano)17(t)-13(her technique )]TJ 0.011 Tw T* [(wi)-24(t)-12.9(h 50% heal)-31(ing r)-32.9(a)15(tes? )]TJ /T1_4 1 Tf (Int J Colorectal Dis.)Tj /T1_1 1 Tf ( 2021;36\(9\):1831\2261837. )Tj 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.1007/s00384-021-03915-9)Tj 0 0 0 1 k /GS1 gs 0.113 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)-16(ilhelm)]TJ /Span<>> BDC ( )Tj EMC (A. A)Tj /Span<>> BDC ( )Tj EMC [(new technique for sphinc)-15.9(ter\226p)25(r)-24(eser)-31.9(v)-16(ing anal f)-28(is)]TJ 0 Tw (-)Tj -0.02 Tw -1.796 -1.25 Td [(tul)-16(a r)-24(ep)32(air using a)]TJ /Span<>> BDC ( )Tj EMC [(novel r)-33(adial emi)-23.9(t)-30(t)-32(ing l)-16(aser p)25(r)-32(obe. )]TJ /T1_4 1 Tf [(T)54(ech Colop)46(roctol.)]TJ /T1_1 1 Tf 0 Tw ( )Tj 0.023 Tw T* [(2011;15:445\226449. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s10151-011-0766-5)Tj 0 0 0 1 k /GS1 gs 0.286 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (Almughamsi)Tj /Span<>> BDC ( )Tj EMC [(AM, Z)10.1(ak)-32(y)]TJ /Span<>> BDC ( )Tj EMC [(MK)-25(S, Alshanqi)-23.9(t)-32(i)]TJ /Span<>> BDC ( )Tj EMC [(AM, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. 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TD [(\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, )0.5(\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\035\026\021\036\030\026\035\034\027\024\n)Tj /Span<>> BDC ( )Tj EMC 18.049 0 Td (\227 \007\035\016 )Tj 0.08 Tw -18.049 -1.218 Td (\235\024\030\n\017\030\024\r\026\027\017\016 \035\024\f\022\031\021\026 \ \r\024\n\024\032\027\024 \024\006\036\027\017\021\034 \007\r\026 \r\026\ )Tj 0 Tw (-)Tj 0.097 Tw T* (\030\017\026\027\021\026, \f\023\030\026\r\026 \017)Tj /Span<>> BDC ( )Tj EMC (\f\035\036\r\026 \024\021 \r\027\031\021\030\036\027\027\036\020\024 \f\r\ \017\013\036\r\024\020\024 )Tj 0 Tw T* (\024\021\r\036\030\f\021\017\016;)Tj 0.255 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-12( )]TJ EMC 1 0 Td (\212\024\f\021\026\021\024\004\027\026\016 \r\026\f\022\031\035\016\030\017\ \026\006\017\016 \023\036\030\036\n\036\013\036\027\027\024\020\024 \035\ \024)Tj 0 Tw (-)Tj 0.13 Tw 0 -1.218 TD [(\f\022\031\021\026: )0.5(\n\024\002\017\035\017\026\006\017\016 )0.6(\035\024\f\022\031\021\026 )0.6(\r\t\023\024\035\027\016\036\021\f\016 )0.6(\f)]TJ /Span<>> BDC ( )Tj EMC 18.673 0 Td (\r\022\035\033)Tj 0 Tw (-)Tj -18.673 -1.218 Td (\004\036\027\017\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\017 \022\026\r\036\030\027\024\027\024\005 \021\022\026\027\017\ ;)Tj 0.02 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-247( )]TJ EMC 1 0 Td (\210\021\f\031\021\f\021\r\017\036 \f\r\016\017 \n\036\032\007\031 \026\ \027\026\021\024\n\017\004\036\f\022\024\005 \024\027\024\005 \220\022\f\ )Tj 0 Tw (-)Tj 0.011 Tw 0 -1.218 TD (\021\030\026\022\006\017\017 \035\024\f\022\031\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\022\035\036\021\004\026\021\024\004\027\t\n\017 \023\030\024\f\021\030\026\ \027\f\021\r\026\n\017, )Tj 0 Tw T* (\020\007\036 \r\024\n\024\032\027\024 \027\026\035\017\004\017\036 \020\ \027\024\005\027\t\b \026\021\036\022\024\r.)Tj 0.156 Tw -1 -1.218 Td (\215\024 \027\026\001\036\n\031 \n\027\036\027\017\033, \n\036\021\024\007\ \035\017\022\r\017\007\026\006\017\017 \r\027\031\021\030\036\027\027\036\ \020\024 )Tj 0.391 Tw 0 -1.218 TD (\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016 \023\036\ \030\036\n\036\013\036\027\027\t\n \035\026\021\036\030\026\035\034\027\t\ \n )Tj 0.039 Tw 0 -1.218 TD (\035\024\f\022\031\021\024\n \n\024\032\036\021 \030\026\f\f\n\026\021\030\ \017\r\026\021\034\f\016 \022\026\022 \024\007\017\027 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\027\024)Tj 0 Tw (-)Tj -0.055 Tw 0 -1.218 TD (\006\036\027\027\t\b \f\023\024\f\024\002\024\r \b\017\030\031\030\020\017\ \004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \253\f\035\024\032\ \027\t\b\273 )Tj -0.001 Tw T* (\023\030\016\n\024\022\017\001\036\004\027\t\b \f\r\017\013\036\005 \f)Tj /Span<>> BDC ( )Tj EMC (\035\033\002\024\005 \035\024\022\026\035\017\026\006\017\036\005 \020\027\ \024\005)Tj 0 Tw (-)Tj 0.229 Tw T* (\027\024\020\024 \023\030\024\006\036\f\f\026, \027\036\f\n\024\021\030\016\ \027\026)Tj /Span<>> BDC ( )Tj EMC (\021\024, \004\021\024 \036\020\024 \220\235\235\036\022\021\017\r)Tj 0 Tw (-)Tj 0.208 Tw T* [(\027\024\f\021\034 )0.5(\f\021\026\021\017\f\021\017\004\036\f\022\017 )0.6(\007\024\f\021\024\r\036\030\027\024 )0.5(\b\031\032\036 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.637 0 Td (\027\026\035\017\004\017\017 )Tj 0.133 Tw -18.637 -1.218 Td [(\020\027\024\005\027\024-\r\024\f\023\026\035\017\021\036\035\034\027\t\b\ )0.7(\026\021\036\022\024\r )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 14.705 0 Td (\n\036\032\f\235\017\027\022\021\036\030\027\024\n, )Tj 0.442 Tw -14.705 -1.218 Td (\017\001\017\024\026\027\026\035\034\027\024\n, \023\036\035\034\r\017\024\ \030\036\022\021\026\035\034\027\024\n \023\030\024\f\021\030\026\027\f\021\ \r\026\b. )Tj 0.286 Tw T* (\215\030\017\027\016\021\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \022\024\027\006\036\ \023\006\017\016 \b\017\030\031\030\020\017\017 )Tj 0.447 Tw T* (\253\f\035\024\032\027\t\b\273 \023\030\016\n\024\022\017\001\036\004\027\ \t\b \f\r\017\013\036\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 )Tj 0.37 Tw T* (\020\027\024\005\027\024\020\024 \023\030\024\006\036\f\f\026 \r)Tj /Span<>> BDC ( )Tj EMC [(\022\035\036\021\004\026\021\024\004\027\t\b )0.5(\023\030\024\f\021\030\026\027\f\021\r\026\b )]TJ -0.004 Tw T* (\023\030\036\007\023\024\035\026\020\026\036\021 \n\027\024\020\024\220\021\ \026\023\027\024\036 \035\036\004\036\027\017\036, \020\007\036 \023\036\ \030\r\t\n \220\021\026)Tj 0 Tw (-)Tj 0.06 Tw T* [(\023\024\n )0.5(\r\t\023\024\035\027\016\036\021\f\016 )0.6(\r\f\022\030\t\021\017\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 12.42 0 Td [(\007\030\036\027\017\030\024\r\026\027\017\036 )0.6(\020\027\024\005\027\t\b )]TJ 0.062 Tw -12.42 -1.218 Td (\026\021\036\022\024\r, \026)Tj /Span<>> BDC ( )Tj EMC (\007\026\035\036\036 \027\036\024\002\b\024\007\017\n \r\t\002\024\030 \n\ \036\021\024\007\026 \030\026\007\017\022\026\035\034)Tj 0 Tw (-)Tj 0.101 Tw T* (\027\024\020\024 \035\036\004\036\027\017\016 \f\r\017\013\026 \023\030\016\ \n\024\005 \022\017\001\022\017. \221\024 \036\f\021\034, \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034)Tj 0 Tw (-)Tj 0.333 Tw T* (\001\017\027\f\021\r\036 \f\035\031\004\026\036\r \023\026\006\017\036\027\ \021\t \253\024\002\030\036\004\036\027\t\273 \027\026, \n\017\027\017)Tj 0 Tw (-)Tj 0.14 Tw T* (\n\031\n, \007\r\036 \024\023\036\030\026\006\017\017. \215\030\036\007\035\ \024\032\036\027\027\t\005 \032\036 \027\026\n\017 \f\023\024\f\024\002 \ )Tj 0.056 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC [(\n\017\027\017\n\026\035\034\027\024\005 \021\030\026\r\n\036 )0.5(\026\027\026\035\034\027\024\020\024 \022\026\027\026\035\026 )0.5(\(\023\024 \f\031\021\017, )]TJ 0.087 Tw T* (\021\030\026\027\f\026\027\026\035\034\027\t\005 \220\021\026\023 \023\024\ )Tj /Span<>> BDC ( )Tj EMC (\031\030\024\r\027\033 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\036\004\036\027\017\016 \023\024\f\035\036 \023\036\030\r\024\005 \024\023\ \036\030\026)Tj 0 Tw (-)Tj 0.215 Tw T* (\006\017\017 \023\030\026\022\021\017\004\036\f\022\017 \031)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\r\017\027\t \023\026\006\017\036\027\021\024\r \f\024 \253\ \f\035\024\032)Tj 0 Tw (-)Tj 0.203 Tw T* [(\027\t\n\017\273 )0.5(\f\r\017\013\026\n\017 \023\030\016\n\024\005 )0.5(\022\017\001\022\017 )0.5(\(50% \023\026\006\017\036\027\021\024\r)]TJ /Span<>> BDC ( )Tj EMC 21.11 0 Td (\227 )Tj -0.054 Tw -21.11 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\035\017\004\017\017 \026\021\036\022\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036; )Tj 0.105 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (52,4% \f\035\031\004\026\036\r)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\001\017\024\026\027\026\035\034\027\024\005 \035\024\022\026\035\017\ \026\006\017\017 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\b\017\030\031\030\020\017\017 \f\035\024\032\027\t\b \f\r\017\ )Tj 0 Tw (-)Tj T* (\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 140.2858 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.274 Tw 10 0 0 10 70.8661 115.9298 Tm (\217\036\031\035\034\021\026\021\t \027\026\001\036\020\024 \017\f\f\035\ \036\007\024\r\026\027\017\016 \023\030\024\007\036\n\024\027\f\021\030\017\ \030\024)Tj 0 Tw (-)Tj 0.113 Tw T* (\r\026\035\017, \004\021\024 \n\036\021\024\007 \035\017\022\r\017\007\026\ \006\017\017 \r\027\031\021\030\036\027\027\036\020\024 \f\r\017\013\036\ \r\024\020\024 )Tj 0.059 Tw T* (\024\021\r\036\030\f\021\017\016 \023\036\030\036\n\036\013\036\027\027\t\ \n \035\026\021\036\030\026\035\034\027\t\n \035\024\f\022\031\021\024\n\ \023\024)Tj 0 Tw (-)Tj -0.072 Tw T* (\r\024\035\016\036\021 \024\007\027\024\220\021\026\023\027\024 \035\017\ \022\r\017\007\017\030\024\r\026\021\034 \253\f\035\024\032\027\t\036\273\ \f\r\017\013\017 )Tj 0.136 Tw 23.244 64.543 Td [(\023\030\016\n\024\005 \022\017\001\022\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(80% \027\026\002\035\033\007\036\027\017\005. \212\r\031\b\220\021\026\023\ \027\024\036 )0.5(\b\017)]TJ 0 Tw (-)Tj 0.089 Tw 0 -1.218 TD (\030\031\030\020\017\004\036\f\022\024\036 \035\036\004\036\027\017\036,\ \r)Tj /Span<>> BDC ( )Tj EMC (\021\024\n \004\017\f\035\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\021\024\030\027\t\n \023\030\017)Tj 0 Tw (-)Tj -0.01 Tw 0 -1.218 TD (\n\036\027\036\027\017\036\n \n\036\021\024\007\026 \214\215\214 \023\024\ \r\024\035\016\036\021 \007\024\002\017\021\034\f\016 \017\035\036\004\ \036\027\017\016 )Tj 0 Tw 0 -1.218 TD (\031)Tj /Span<>> BDC ( )Tj EMC (96,7% \023\026\006\017\036\027\021\024\r.)Tj 0.427 Tw 0 -1.218 TD (\211\004\017\021\t\r\026\016 \n\017\027\017\n\026\035\034\027\t\005 \030\ \017\f\022 \030\026\r\017\021\017\016 \023\024\f\035\036\024\023\036)Tj 0 Tw (-)Tj 0.813 Tw 0 -1.218 TD [(\030\026\006\017\024\027\027\t\b )0.5(\024\f\035\024\032\027\036\027\017\005, )0.6(\027\017\022\031\033 )0.6(\017\027\021\036\027\f\017\r\027\024\f\021\034 )]TJ 0.835 Tw 0 -1.218 TD (\002\024\035\036\r\024\020\024 \f\017\027\007\030\024\n\026, \024\021\f\031\ \021\f\021\r\017\036 \024\021\030\017\006\026\021\036\035\034\027\024\020\ \024 )Tj 0.463 Tw 0 -1.218 TD (\r\035\017\016\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC (\235\031\027\022\006\017\024\027\026\035\034\027\024\036 \f\024\f\021\024\ \016\027\017\036 \026\027\026\035\034\027\024)Tj 0 Tw (-)Tj 0.532 Tw T* [(\020\024 )0.5(\f\235\017\027\022\021\036\030\026, )0.6(\n\036\021\024\007 )0.5(\214\215\214 )0.5(\016\r\035\016\036\021\f\016 )0.6(\002\036\024\023\026\f\027\t\n )]TJ 0 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\021\030\026\r\n\026\021\017\004\027\t\n.)Tj /T1_2 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_0 1 Tf 0.389 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.3(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_3 1 Tf [( \215)8.4(\r)7.1(\030)2.7(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.01 Tc 0.01 Tw T* [(\001)4.6(\022)-2.3(\n)2.7(\022\213\022)-2.7(\025)]TJ /Span<>> BDC 3.69 0 Td ( )Tj EMC [()55(.)18.5(\211)14.4(.)]TJ /T1_0 1 Tf 0 Tc 0.716 Tw -3.69 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.8(\024)-11(\021)-17.6(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_3 1 Tf -0.01 Tc 0.726 Tw [( \001)4.6(\022)-2.3(\n)2.8(\022\213\022)-2.8(\025)]TJ /Span<>> BDC 19.526 0 Td ( )Tj EMC [()55(.)18.5(\211)14.3(.)-2.2(,)-10( )]TJ 0 Tc 0 Tw -19.526 -1.218 Td [(\215)8.4(\r)7.1(\030)2.7(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)7.8(, \004)8.8(\027)-0.9(\032)5.9(\213)9.6(\022)7.2(\025)9.6(\020)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)30.3(\036)22.8(.)7.8(, )]TJ /T1_0 1 Tf (\212\026\007\026\001\036\r \230.\230.)Tj 0.002 Tc -0.002 Tw T* [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 7.694 0 Td [( \215)8.4(\r)7.1(\030)2.7(\032\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.2(.)7.3(\003)-2.3(.)7.8(, \001)14.6(\022)7.7(\n)12.7(\022)9.6(\213)9.6(\022)7.3(\025)]TJ /Span<>> BDC ( )Tj EMC [()65(.)28.5(\211)24.3(.)]TJ /T1_0 1 Tf 0.126 Tw -7.694 -1.218 Td [(\222)17.2(\021)-21.5(\026)-11.8(\021)-17.7(\017)-2.4(\f)-36(\021)-17.7(\017)4.6(\004)-8.2(\036)-10.4(\f)-1.6(\022)-19.1(\026)-21.1(\016 \024)-11.8(\002)3(\030)-11.3(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \007)-20.1(\026\027)1.7(\027)1.7(\t)-12.8(\b)-9.3(:)]TJ /T1_3 1 Tf -0.007 Tc 0.133 Tw [( \002)16.2(\b\025)2.5(\020)-5.2(\023)-3(\027)-4.7(\025)3.8(\n)2.7(\031)]TJ /Span<>> BDC 19.802 0 Td ( )Tj EMC [(\215)12.4(.\003)-9.3(.)0.8(,)-7( )]TJ -0.01 Tc 0.01 Tw -19.802 -1.218 Td [(\001)4.6(\022)-2.3(\n)2.7(\022\213\022)-2.7(\025)]TJ /Span<>> BDC 3.69 0 Td ( )Tj EMC [()55(.)18.5(\211)14.4(.)-2.2(,)-10( \234)5.1(\020)-8.2(\032)-4.1(\n\031\021)]TJ /Span<>> BDC 5.23 0 Td ( )Tj EMC [(\036)12.8(.)20.3(\036)12.9(.)]TJ /T1_0 1 Tf 0 Tc 0 Tw -8.92 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.4(\030)-11.8(\024)-4.2(\r)-9(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_3 1 Tf 0.839 Tw [( \215)8.4(\r)7.1(\030)2.8(\032\031)9.7(\021)]TJ /Span<>> BDC ( )Tj EMC [(\003)-2.3(.)7.3(\003)-2.3(.)7.9(, \202)15.6(\031)-0.8(\024\023)6.9(\020)1.9(\032\027)6.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\002)28.9(.)28.5(\211)24.3(.)7.8(, )]TJ -0.01 Tc 0.01 Tw T* [()42.8(\022)-2.3(\023)-5.9(\031\021)]TJ /Span<>> BDC 2.519 0 Td ( )Tj EMC [(\003)-12.3(.)17.5(\224)16.7(.)-2.2(,)-10( \221)4.6(\022)-5.3(\032)-4.6(\005)-4.7(\n\031\021)]TJ /Span<>> BDC 6.017 0 Td ( )Tj EMC [(\217)17.6(.)10.1(\215)9.5(.)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -8.536 -2.436 Td (AUTHORS CONTRIBUTION)Tj /T1_0 1 Tf 0.194 Tw T* [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_3 1 Tf [( A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.4(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.2(r)2.4(o)-0.6(v)33.7(, )]TJ -0.008 Tc 0.008 Tw T* [(T)-10.7(im)-2.8(u)-1.8(r)]TJ /Span<>> BDC 2.199 0 Td ( )Tj EMC [(V)45.1(.)]TJ /Span<>> BDC 0.955 0 Td ( )Tj EMC [(Nik)-26.4(i)3(s)1.6(h)-1.8(in)]TJ /T1_0 1 Tf 0 Tc 1.014 Tw -3.154 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_3 1 Tf 0 Tw ( )Tj -0.086 Tw -15.798 -1.218 Td [(T)-2.7(i)8.4(m)5.2(u)6.1(r)]TJ /Span<>> BDC ( )Tj EMC 2.346 0 Td [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8(i)7.9(k)-18.5(i)11.1(s)9.6(h)6.2(i)8.4(n)-6(, A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.5(d)5.2(r)2.4(o)-0.6(v)33.6(, A)3.8(n)4.8(a)-3(s)-10.7(t)2.3(a)-3(s)-8.3(i)6(a E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(P)24(e)-1.7(r)-10.7(s)9.6(h)6.2(i)8.4(n)4.8(a)-14(, )]TJ -0.002 Tc 0.002 Tw -2.346 -1.218 Td [(I)4.1(k)0.9(ro)-1.6(m)6.8(z)6.1(ho)-1.6(n)]TJ /Span<>> BDC 4.161 0 Td ( )Tj EMC (I.)Tj /Span<>> BDC 0.864 0 Td ( )Tj EMC [(D)-5.2(a)-6.5(da)-4.9(s)7.6(he)-6(v)]TJ /T1_0 1 Tf -0.052 Tc 0.052 Tw -5.025 -1.218 Td [(Te)-75.9(x)-88(t)-52( w)-73(r)-99.9(i)-58(t)-89.4(i)-44.9(n)-53.9(g)-43(:)]TJ /T1_3 1 Tf 0 Tc 0 Tw 5.233 0 Td [( A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.5(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.2(r)2.4(o)-0.6(v)33.6(, T)-2.6(i)8.4(m)5.2(u)6.1(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.1(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8.1(i)7.9(k)-18.5(i)11(s)9.6(h)6.2(i)8.4(n)]TJ /T1_0 1 Tf -0.007 Tc 1.28 Tw -5.233 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_3 1 Tf 0 Tc 1.273 Tw 10.361 0 Td [( M)5.2(ar)-35.3(i)5.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(I)10.1(g)1.8(n)4.9(a)-4.9(t)2.8(e)-2.6(n)7.5(k)12.9(o)-3.7(, )]TJ 0 Tw -10.361 -1.218 Td [(T)-2.7(i)8.4(m)5.2(u)6.1(r)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(N)8(i)7.9(k)-18.5(i)11.1(s)9.6(h)6.1(i)8.5(n)-6(, E)20.6(v)8.2(g)-2.5(e)-2.6(n)6.2(y)]TJ /Span<>> BDC ( )Tj EMC [(E)19.8(.)]TJ /Span<>> BDC ( )Tj EMC [(Z)1.8(h)4.8(ar)-2.5(k)12.9(o)-0.6(v)]TJ /T1_0 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_3 1 Tf 0 Tc 0.837 Tw 3.238 0 Td [( A)3.8(n)-0.6(d)5.2(r)2.4(e)-2.4(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(u)-1.6(d)5.3(r)2.4(o)-0.6(v)33.6(, I)14(v)10.8(a)-0.8(n)]TJ /Span<>> BDC ( )Tj EMC [(V)53.2(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(o)3.3(s)-10.7(t)2.3(ar)2.4(e)-4(v)33.6(, )]TJ -0.005 Tc 0.005 Tw -3.238 -1.218 Td [(A)-1.4(le)-33.6(xa)-5.8(n)-5.6(d)-6(e)-6.7(r)]TJ /Span<>> BDC 3.884 0 Td ( )Tj EMC [(Y)28.7(u)2.7(.)]TJ /Span<>> BDC 1.43 0 Td ( )Tj EMC [(T)-7.7(i)-4.1(t)-3.6(o)-5.6(v)28.6(,)-5( O)-12.3(le)-8.5(g)]TJ /Span<>> BDC 4.261 0 Td ( )Tj EMC (M.)Tj /Span<>> BDC 1.172 0 Td ( )Tj EMC [(Bi)4.4(r)-45.2(y)-1.2(uk)7.9(o)-5.5(v)]TJ /T1_2 1 Tf 0 Tc 0.023 Tw -10.747 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_0 1 Tf 1.391 Tw T* (\203\017\022\017\001\017\027 \221\017\n\031\030 \200\035\026\007\017\n\017\ \030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \r\030\026\004-)Tj 0.944 Tw T* [(\022\024\035\024\023\030\024\022\021\024\035\024\020, )0.6(\205\206\207\211 )0.5(\253\203\204\230\037 )0.5(\022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 )]TJ 0.629 Tw T* (\017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0000-0001-6991-1716)Tj 0.01 Tc 0.391 Tw T* (\025\024\f\021\026\030\036\r \230\r\026\027 \200\026\f\017\035\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \030\031\022\024\r\024\007\017)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.591 Tw T* [(\021\036\035\034 )0.5(\024\021\007\036\035\026 )0.5(\024\002\013\036\005 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 11.222 0 Td [(\030\036\022\024\027\f\021\030\031\022\021\017\r\027\024\005 )0.5(\022\024\035\024)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.339 Tw -11.222 -1.218 Td (\023\030\024\022\021\024\035\024\020\017\017 \205\206\207\211 \253\203\204\ \230\037 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017 \017\ \n\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.452 Tw T* (\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC [(\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; \023\030\024\235\036\f\f\024\030)10( )]TJ 0.062 Tw T* [(\022\026\235\036\007\030\t \022\024\035\024\023\030\024\022\021\024\035\024\ \020\017\017 \205\206\207\210\211 \212\215\210 \253\217\024\f\f\017\005\f\ \022\026\016)10( )]TJ 0.283 Tw T* (\n\036\007\017\006\017\027\f\022\026\016 \026\022\026\007\036\n\017\016 \ \027\036\023\030\036\030\t\r\027\024\020\024 \023\030\024\235\036\f\f\017\ \024)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.23 Tw T* [(\027\026\035\034\027\024\020\024 \024\002\030\026\024\r\026\027\017\016\ \273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID)10( )]TJ -0.01 Tw T* (0000-0002-1778-0571)Tj 0 Tc 0.171 Tw T* (\221\017\021\024\r \202\035\036\022\f\026\027\007\030 \224\030\034\036\r\ \017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \020\035\026\r\027\t\005 \027\026\031\004)Tj 0 Tw (-)Tj 0.238 Tw T* (\027\t\005 \f\024\021\030\031\007\027\017\022 \024\021\007\036\035\036\027\ \017\016 \024\002\013\036\005 \017)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\024\027\f\021\030\031\022\021\017\r)Tj 0 Tw (-)Tj 0.318 Tw T* (\027\024\005 \022\024\035\024\023\030\024\022\021\024\035\024\020\017\017\ \205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024)Tj 0 Tw (-)Tj 0.251 Tw T* (\020\017\017 \017\n\036\027\017 \202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ ; ORCID )Tj 0 Tw T* (0000-0002-1636-8075)Tj 0.221 Tw T* (\230\020\027\026\021\036\027\022\024 \204\026\030\017\016 \202\027\007\030\ \036\036\r\027\026)Tj /Span<>> BDC ( )Tj EMC (\227 \f\023\036\006\017\026\035\017\f\021 \024\021\007\036\035\026 )Tj 0.045 Tw T* (\023\035\026\027\017\030\024\r\026\027\017\016 \017)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\017\026\006\017\017 \027\026\031\004\027\t\b \017\f\ \f\035\036\007\024\r\026\027\017\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.19 56.0378 Tm (78)Tj ET endstream endobj 1165 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.285 Tw 10 0 0 10 42.5197 517.8039 Tm (\027\026)Tj /Span<>> BDC ( )Tj EMC 1.491 0 Td [(\030\036\031\035\034\021\026\021 )0.6(\023\030\017\n\036\027\036\027\017\016 )0.5(\214\215\214, )0.5(\017\035\036\004\036\027\017\016 )0.5(\031\007\026\035\024\f\034 )]TJ 0.236 Tw -1.491 -1.218 Td [(\007\024\002\017\021\034\f\016 )0.6(\002\024\035\036\036 )0.5(\004\036\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 9.99 0 Td [(60% )0.5(\021\026\022\024\020\024 )0.5(\030\024\007\026 )0.6(\023\026\006\017\036\027\021\024\r )]TJ 0 Tw -9.99 -1.218 Td (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (9\).)Tj 0.172 Tw 0 -1.218 TD [(\217\036\006\017\007\017\r )0.5(\026\002\024\035\036\r\026\027\017\016 )0.5(\r\t\016\r\035\036\027 \r)]TJ /Span<>> BDC ( )Tj EMC [(12/60 )0.5(\(20,0%\) \027\026)]TJ 0 Tw (-)Tj 0.16 Tw T* (\002\035\033\007\036\027\017\016\b. \230)Tj /Span<>> BDC ( )Tj EMC (\027\017\b \024\021 \007\026\035\034\027\036\005\001\036\020\024 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 )Tj 0.024 Tw T* (\035\036\004\036\027\017\016 \024\021\022\026\026\035\017\f\034 2/12 \(\ 16,7%\) \002\024\035\034\027\t\b. \215\024\r\021\024\030\027\024 )Tj 0.439 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033\013\017\036 4\2269)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \002\t\035\017 \024\023\036\030\017\030\024\r\026\ \027\t )Tj -0.012 Tw T* (10/60 \(16,7%\) \023\026\006\017\036\027\021\024\r. \200)Tj /Span<>> BDC ( )Tj EMC (8/10 \(80,0%\) \f\035\031\004\026\016\b \r\t)Tj 0 Tw (-)Tj 0.079 Tw T* (\023\024\035\027\036\027\024 \023\030\024\r\036\007\036\027\017\036 \007\ \030\036\027\017\030\031\033\013\036\005 \035\017\020\026\021\031\030\t.\ \212\026\035\036\036, )Tj 0.514 Tw T* (\031\004\017\021\t\r\026\016 \007\017\f\021\026\035\034\027\031\033 \n\017\ \020\030\026\006\017\033 \f\r\017\013\036\r\024\020\024 \b\024\007\026 )Tj 0.314 Tw T* (\023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \035\026\021\036\ \030\026\035\034\027\024\020\024 \035\024\f\022\031\021\026 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036)Tj 0 Tw (-)Tj 0.113 Tw T* (\007\031\033\013\036\005 \n\017\020\030\026\006\017\017 \035\017\020\026\ \021\031\030\t, \r\024 \r\f\036\b 8 \027\026\002\035\033\007\036\027\017\ \016\b )Tj 0.027 Tw T* (\r\t\023\024\035\027\036\027\024 \024\023\036\030\026\021\017\r\027\024\036\ \r\n\036\001\026\021\036\035\034\f\021\r\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\255\036\n\036 \017\f)Tj 0 Tw (-)Tj 0.037 Tw T* (\f\036\004\036\027\017\016 \f\r\017\013\026 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021 \022\017\001\022\017. \200)Tj /Span<>> BDC ( )Tj EMC (1/10 \(10,0%\) \f\035\031)Tj 0 Tw (-)Tj -0.033 Tw T* (\004\026\036 \f\r\017\013 \031\f\023\036\001\027\024 \035\017\022\r\017\007\ \017\030\024\r\026\027 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \023\036\030\036\r\016)Tj 0 Tw (-)Tj 0.021 Tw T* (\022\017 \f\r\017\013\036\r\024\020\024 \b\024\007\026 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \023\030\024\f\021\030\ \026\027\f\021\r\036. )Tj 0.167 Tw T* (\200)Tj /Span<>> BDC ( )Tj EMC (1/10 \(10,0%\) \027\026\002\035\033\007\036\027\017\017, \023\024\r\021\024\ \030\027\024 \017\f\023\024\035\034\024\r\026\027 )Tj 0.029 Tw T* (\n\036\021\024\007 \023\036\030\036\n\036\013\036\027\017\016 \214\215\214\ \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\017\021\036\035\034\027\t\n \030\036\031\035\034\021\ \026)Tj 0 Tw (-)Tj T* (\021\024\n \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 262.0659 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.128 Tw 10 0 0 10 42.5197 237.7099 Tm [(\215\030\024\021\024\021\017\023\024\n )0.5(\007\035\016 \n\036\021\024\007\026 )0.5(\214\215\214 \016\r\035\016\036\021\f\016 )0.5(\027\026\017\002\024\035\036\036 )0.5(\023\024)]TJ 0 Tw (-)Tj 0.037 Tw T* (\023\031\035\016\030\027\t\005 \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \f\023\024\f\024\002\ \b\017\030\031\030\020\017\004\036\f\022\024\020\024 )Tj 0.187 Tw T* (\035\036\004\036\027\017\016 \253\f\035\024\032\027\t\b\273 \f\r\017\013\ \036\005 \023\030\016\n\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \023\030\016)Tj 0 Tw (-)Tj 0.045 Tw T* (\n\024\022\017\001\036\004\027\t\005 \(\023\030\024\022\f\017\n\026\035\034\ \027\t\005\) \035\024\f\022\031\021, \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036\027\017\033 )Tj 0.135 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\t\n, \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\001\036\n\031 \n\027\036\027\017\033, \031)Tj /Span<>> BDC ( )Tj EMC (\035\026\021\036\030\026\035\034\027\024\020\024 \023\030\016)Tj 0 Tw (-)Tj 0.192 Tw T* (\n\024\022\017\001\036\004\027\024\020\024 \035\024\f\022\031\021\026 \r\ )Tj /Span<>> BDC ( )Tj EMC (\024\023\030\036\007\036\035\036\027\027\t\b \022\035\017\027\017\004\036\ \f\022\017\b )Tj 0 Tw T* (\f\017\021\031\026\006\017\016\b \036\f\021\034 \030\016\007 \023\030\036\ \017\n\031\013\036\f\021\r:)Tj 0.109 Tw T* (\251)Tj /Span<>> BDC [( )-158( )]TJ EMC 1 0 Td [(\204\036\021\024\007 \002\024\035\036\036 \023\030\024\f\021 \021\036\b\027\ \017\004\036\f\022\017, )0.5(\021\026\022 \022\026\022 \253\031\020\024\035 \026\021\026)]TJ 0 Tw (-)Tj 0.265 Tw T* (\022\017 \b\017\030\031\030\020\026\273 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\024\002\017\035\017\026\006\017\017 \035\026\021\036\030\026\035\034\ \027\024\020\024 \035\024)Tj 0 Tw (-)Tj 0.103 Tw T* [(\f\022\031\021\026 \030\026\f\023\024\035\026\020\026\036\021\f\016 \f\031\ \013\036\f\021\r\036\027\027\024 )0.5(\007\017\f\021\026\035\034\027\036\036, \004\036\n )]TJ 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\022\f\017\n\026\035\034\027\024\n \035\024\f\022\031\021\036\ ;)Tj 0.008 Tw -1 -1.218 Td (\251)Tj /Span<>> BDC [( )-259( )]TJ EMC 1 0 Td [(\200\024\n\024\032\027\024\f\021\034 )0.5(\r\t\002\024\030\026 \027\026\017\002\024\035\036\036 )0.5(\024\023\021\017\n\026\035\034\027\024\005 \021\022\026\027\017 )]TJ 0.06 Tw T* [(\007\035\016 )0.5(\235\024\030\n\017\030\024\r\026\027\017\016 \035\024\f\022\031\021\026.\ )0.5(\221\026\022, \036\f\035\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC (\023\030\024\022\f\017)Tj 0 Tw (-)Tj 0.075 Tw T* (\n\026\035\034\027\024\n \035\024\f\022\031\021\036 \027\036\021 \026\035\ \034\021\036\030\027\026\021\017\r\t \024\021\007\036\035\031 \023\030\016\ \n\024\005 )Tj ET q 274.961 483.166 221.102 241.171 re W n q /GS0 gs 221.1023475 0 0 241.2680546 274.9606228 483.0686982 cm /Im0 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.073 Tw 9 0 0 9 274.9606 472.3656 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf ( ROC-\n\032\022\021\020\t \016\020\021\022\024\022\026\031\024\023\022 \032\ \027\006\022\030\022\021\020 \205\004\202 \031\023 \022\025)Tj 0 Tw (-)Tj 0.148 Tw 0 -1.2 TD (\030\027\n\024\020 \026\020\024\024\013 \023\027\f\020. AUC)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,09 \(95% \220\002 0,53; 0,88\), )Tj 0.056 Tw T* (\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,032, \023\031\007\n\020 \031\023\024\027\007\n\022 \024\031\031\023\021\ \027\023\024\023\021\r\027\023 30,7 \n\b/\026\262. \232\r\021)Tj 0 Tw (-)Tj 0.059 Tw T* (\024\023\021\022\023\027\f\017\025\031\024\023\017)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66,7% \(95% \220\002 34,9; 90,1%\). \205\033\027\006\022\203\022\007)Tj 0 Tw (-)Tj 0.079 Tw T* (\025\031\024\023\017)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (81,3% \(95% \220\002 67,4; 91,1%\). \004\037\004\206)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (47,1% \(95% )Tj 0 Tw T* (\220\002 23,0; 72,2%\). \004\037\217\206)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90,7% \(95% \220\002 77,9; 97,4%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.086 Tw T* [(F)-16(igure 2)16(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( R)19(OC is the)]TJ /Span<>> BDC ( )Tj EMC [(cur)-42(v)13(e of)]TJ /Span<>> BDC ( )Tj EMC [(AF recur)-15.9(rence v)13(ersus body mass )]TJ 0.079 Tw T* [(inde)-15(x. A)29(UC)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0.09 \(95% CI 0.53; 0.88\), p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.032, cut-)Tj 0.16 Tw T* [(of)-40(f point cor)-16(responds tok)15(g/m2. TP)66(R)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (66.7% \(95% CI 34.9; )Tj -0.02 Tw T* [(90.1%\). FP)66(R)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(81.3% \(95% CI 67.4; 91,1%\). PPV \(positiv)13(e p)46(re)]TJ 0 Tw (-)Tj 0.079 Tw T* [(dictiv)13(e )0.5(v)16(alue\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(47.1% )0.5(\(95% CI )0.5(23.0; 72.2%\). NPV )0.5(\(neg)12(ativ)13(e )]TJ 0 Tw T* [(p)46(redictiv)13.1(e v)16(alue\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (90.7% \(95% CI 77.9; 97.4%\))Tj ET q 274.961 122.57 221.102 220.492 re W n q /GS0 gs 221.1023475 0 0 220.6222255 274.9606228 122.4394817 cm /Im1 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tw 9 0 0 9 274.9606 111.7701 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( \020\n\023\022\n\020 \030\020\f\017\025\027\235\213\027\b\031 \f\027\007\ \027\025\022\t )0.5(\033\020\006\022\027\025\023\031\021 \024)]TJ /Span<>> BDC ( )Tj EMC (\032\027)Tj 0 Tw (-)Tj T* (\006\022\030\022\021\031\026 \205\004\202 \033\031\024\f\027 \033\032\022\ \026\027\025\027\025\022\t \f\020\023\027\032\020\f\017\025\031\b\031 \f\ \031\024\n\r\023\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.046 Tw T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( Manag)12(ement strategy for patients with recur)-16(rent ano)]TJ 0 Tw (-)Tj T* [(rectal f)-42.9(istula af)-45.9(ter lateral f)-21.9(lap p)46.1(rocedure)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.005 Tw -25.827 72.346 Td [(\020\004\206\f\t\204\004 )0.5(9.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( )0.5(\211\f\022\t\025\022\027 )0.5(\025\020\f\022\007\022\t \b\025\031\235\025\013\200 )0.5(\016\020\023\027\n\031\021 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 20.248 0 Td [(\022\200 )0.5(\f\031\n\020\f\022)]TJ 0 Tw (-)Tj 0.094 Tw -20.248 -1.2 Td (\016\020\006\022\022 \025\020)Tj /Span<>> BDC ( )Tj EMC (\204\203\203\027\n\023\022\021\025\031\024\023\017 \026\027\023\031\030\020\ \035\004\035 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\f\027\007\027\025\022\022 \024\f\031\255)Tj 0 Tw (-)Tj 0 -1.2 TD (\025\013\200 \024\021\022\212\027\235 \033\032\t\026\031\235 \n\022\213\n\ \022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.102 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 9.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0.075 Tw 3.374 0 Td [( I)2.3(m)-1(p)-6.3(a)-9.2(c)-32.4(t o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-3(u)1.6(r)-9.1(u)-1.5(le)-7(n)-0.6(t c)2.8(o)-5.3(l)-3.8(le)-10.9(c)-32.4(t)-29.1(i)-1.4(o)-4(n)3.7(s a)-5.1(n)-4.8(d t)-10.6(h)-2.4(e)-6.2(i)4.9(r l)-1.6(o)-12.4(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n o)-3.9(n )]TJ 0 Tw -3.374 -1.2 Td [(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)6.7(u)-3.7(c)2.3(c)2.9(e)-22(s)-10.5(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(L)-5.6(R)6.8(F i)3.9(n c)2.8(o)-4(m)-1(p)-4.9(le)-32.3(x a)-5.1(na)-4.5(l \243)6.4(s)-14.8(t)-1.1(u)-1.6(l)-1(a)-7.2(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 682.781 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 184.502 682.781 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 263.872 661.9618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 42.5197 661.7118 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 661.7118 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 650.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 650.2505 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 650.2505 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 639.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 638.7892 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 638.7892 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 627.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 627.3279 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 627.3279 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 616.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 615.8666 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 604.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 615.8666 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 604.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 604.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 604.4054 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 593.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 604.4054 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 593.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 593.1941 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 592.9441 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 581.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 592.9441 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 581.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 581.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 581.4828 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 570.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 581.4828 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 570.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 570.2715 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 570.0215 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 558.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 570.0215 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 558.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 558.8102 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 558.5602 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 42.7697 547.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 184.502 558.5602 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 184.502 547.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 263.872 547.3489 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 547.0989 cm 0 0 m 141.982 0 l S Q q 1 0 0 1 184.502 547.0989 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 54.2607 674.1464 Tm (\025\004\f\t\201\t\r, \216\004\006\004\220\003\r\006 \t)Tj /Span<>> BDC ( )Tj EMC (\f\002\220\004\f\t\213\004\204\t\235 )Tj 3.75 -1.2 Td (\n\b\002\005\b\013\216 \213\004\003\r\220\002)Tj 13.099 1.2 Td (\021\002\f-\002 \013\f\r\201\r\b\b\013\216 )Tj -0.124 -1.2 Td (\212\004\204\t\r\b\003\002 \()Tj /T1_5 1 Tf (n)Tj /T1_3 1 Tf (/N\(%\)\))Tj /T1_1 1 Tf -17.807 -1.433 Td (\206\027\024\005\027\t\036 \026\021\036\022\017)Tj 19.393 0 Td (28/39)Tj /Span<>> BDC ( )Tj EMC (\(71,8%\))Tj -19.393 -1.433 Td (\204\027\024\032\036\f\021\r\036\027\027\t\036 \020\027\024\005\027\t\036\ \026\021\036\022\017)Tj 19.393 0 Td (15/23)Tj /Span<>> BDC ( )Tj EMC (\(65,2%\))Tj -19.393 -1.433 Td (\204\036\032\f\235\017\027\022\021\036\030\027\t\005 \026\021\036\022)Tj 19.893 0 Td (4/8)Tj /Span<>> BDC ( )Tj EMC (\(50,0%\))Tj -19.893 -1.433 Td (\230\001\017\024\026\027\026\035\034\027\t\005 \026\021\036\022)Tj 19.393 0 Td (11/21)Tj /Span<>> BDC ( )Tj EMC (\(52,4%\))Tj -19.393 -1.433 Td (\215\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\005 \026\021\ \036\022)Tj 19.893 0 Td (4/9)Tj /Span<>> BDC ( )Tj EMC (\(44,4%\))Tj -19.893 -1.433 Td (\217\036\021\030\024\030\036\022\021\026\035\034\027\t\005 \026\021\036\ \022)Tj 19.643 0 Td (8/11)Tj /Span<>> BDC ( )Tj EMC (\(72,7%\))Tj -19.643 -1.433 Td (\215\024\007\f\035\017\017\f\021\t\005 \026\021\036\022)Tj 20.314 0 Td (\275\(50,0%\))Tj -20.314 -1.433 Td (\200\027\031\021\030\017\f\021\036\027\024\004\027\t\005 \026\021\036\022\ )Tj 19.893 0 Td (1/3)Tj /Span<>> BDC ( )Tj EMC (\(33,3%\))Tj -19.893 -1.433 Td (\215\024\007\022\024\032\027\t\005 \026\021\036\022)Tj 19.393 0 Td (13/16)Tj /Span<>> BDC ( )Tj EMC (\(81,3%\))Tj -19.393 -1.433 Td (\003\026\021\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005 \023\036\030\ \036\020\024\030\024\007\022\036)Tj 19.985 0 Td (5/5)Tj /Span<>> BDC ( )Tj EMC (\(100%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.9518 56.0378 Tm (77)Tj ET endstream endobj 1166 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   {!A16QUbu"#%23CRSTa $&'()*45789:BDEFGHIJVWXYZcdefghijqrstvwxyz {!1AQ"q2Ra4B3CSrst #$%&'()*56789:DEFGHIJTUVWXYZbcdefghijuvwxyz?0Ъ0i$nWr53w6ݵ׺18ؘx[Q85q Jnje rn:]ubJΪIp8^6!{sޞ䧻V*vk 71-\n#NZ)[yuO/puչw6\Q)qï *&]^>s57'}zq+zq+`<4J!<4J!| .'wa 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<SkN^jZFLܔ=?-f)VQͮ:/k^qte"Ys}y[(x.eDPViKU s 4o%̳N 1UYD̲ij/LN4DË!J Hk#=+W(ԲU"M4s|TB0Ĉ&,/ ;PAAAAAAAAAAӮxNE<JٕDܽ2Yp6\9~9"ַ[3Kֲ@UxW8qvqT3ˡ BF(<RlK.'O\48aˁ MDCKɲn%S @ (v8Æ:(6}([iK2[ Sb1PogZl˔(KXJĪ<97iHȦIJGf];XlݹBKe Nψ׎Qv $2lN $t]Oq6Rd"awx7mF>*ߢ*3+ځcLX^Avb)         ԮxNE<AۯS2 v](u (; ]Щ&59< R`TJJsp!]K+2*$LU 3Pmf'`xx"$[[XH2:s,`5Ch "b Oõ{OAAAAAAAAA@ծxNE<AG!c*8p#9AALX^Avb)         ֮7KijBkIA?q蘧   "bSgjN }SAAAAAAAAAnJ*kd/be-ޅY VhVRxp{ìMDzh7Nr#At߇l{ Ӧ;c܈n7Gt"=4Mvǹ:oö=ȏM~Dzh7Nr#At߇l{ Ӧ;c܈n7GiiJ`x{OU+YG&J!ZXޒIҥRؖu+K=L{         c9Ojeey pDևr%} ;+15܉_q=aJA hw"WbXkCzZȕDևr%} ;+15܉_q=aJGc)JHevJ[GH;          endstream endobj 1222 0 obj <>stream endstream endobj 1221 0 obj <>stream endstream endobj 1164 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.286 Tw 10 0 0 10 70.8661 335.1339 Tm (\200\f\036 \023\026\006\017\036\027\021\t \r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 3\2266)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\016\006\036\r \024\002\f\035\036\007\024\r\026\027\t. )Tj 0.233 Tw 0 -1.218 TD (\215\024)Tj /Span<>> BDC ( )Tj EMC 1.566 0 Td [(\007\026\027\027\t\n )0.5(\022\035\017\027\017\022\024-\017\027\f\021\030\031\n\036\027\021\026\035\ \034\027\024\020\024 )0.6(\024\002\f\035\036\007\024\r\026)]TJ 0 Tw (-)Tj 0.194 Tw -1.566 -1.218 Td (\027\017\016, \030\036\006\017\007\017\r \026\002\024\035\036\r\026\027\ \017\016 \007\017\026\020\027\024\f\021\017\030\024\r\026\027 \031)Tj /Span<>> BDC ( )Tj EMC (12/60 )Tj 0.1 Tw T* (\(20,0%; 95% \212\230: 10,8\22632,3\) \023\026\006\017\036\027\021\024\r\ . \221\026\022\017\n \024\002\030\026)Tj 0 Tw (-)Tj 0.203 Tw T* [(\024\n, )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\034 )0.7(\n\036\021\024\007\026 )0.5(\f\024\f\021\026\r\017\035\026 )0.5(48/60 )0.5(\(80%; )]TJ 0 Tw T* (95% \212\230 67,7; 89,2\) \f\035\031\004\026\036\r.)Tj 0.108 Tw T* [(\210\006\036\027\022\026 )0.5(\235\031\027\022\006\017\024\027\026\035\034\027\024\020\024 )0.5(\f\024\f\021\024\016\027\017\016 )0.6(\026\023\017\030\026\021\036\035\034\027\024\020\024 )]TJ 0.18 Tw T* [(\026\023\023\026\030\026\021\026 )0.5(\023\030\016\n\024\005 )0.6(\022\017\001\022\017 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 12.599 0 Td [(\023\024\n\024\013\017 )0.5(\f\235\017\027\022\021\036\030\024\n\036)]TJ 0 Tw (-)Tj 0.137 Tw -12.599 -1.218 Td (\021\030\017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\t W)22(e)-18(xner, \r\t\023\024\035\027\036\027\027\024\036 \031)]TJ /Span<>> BDC ( )Tj EMC (46 \023\026\006\017\036\027\021\024\r )Tj 0.059 Tw T* [(\023\024\f\035\036 \024\023\036\030\026\006\017\017, \023\024\022\026\026\ \035\026 )0.5(\024\021\f\031\021\f\021\r\017\036 \023\024\r\030\036\032\007\026\033\013\ \036)]TJ 0 Tw (-)Tj 0.187 Tw T* (\020\024 \r\024\007\036\005\f\021\r\017\016 \n\036\021\024\007\026 \214\ \215\214 \027\026)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\t\005 \f\235\017\027\022\021\036\030 )Tj 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (7\).)Tj 0.067 Tw T* (\212\035\016 \024\006\036\027\022\017 \r\024\n\024\032\027\t\b \023\030\ \036\007\017\022\021\024\030\024\r \030\026\r\017\021\017\016 \030\036\006\ \017)Tj 0 Tw (-)Tj 0.132 Tw T* (\007\017\r\026 \f\r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017\ \023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \023\036\030\036\ )Tj 0 Tw (-)Tj 0.27 Tw T* (\n\036\013\036\027\027\024\020\024 \035\026\021\036\030\026\035\034\027\024\ \020\024 \035\024\f\022\031\021\026 \r\t\023\024\035\027\036\027 \031\027\ \017\r\026)Tj 0 Tw (-)Tj 0.41 Tw T* (\030\017\026\027\021\027\t\005 \026\027\026\035\017 \023\024\021\036\027\ \006\017\026\035\034\027\t\b \235\026\022\021\024\030\024\r \030\017\f\022\ \026 )Tj 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (8\).)Tj 0.002 Tc 0.098 Tw T* [(\210\007\027\017\n )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 4.275 0 Td [(\r\t\016\r\035\036\027\027\t\b )0.5(\235\026\022\021\024\030\024\r, )0.5(\023\024\r\t\001\026\033\013\017\n )0.5(\030\017\f\022)2( )]TJ 0.399 Tw -4.275 -1.218 Td (\030\026\r\017\021\017\016 \030\036\006\017\007\017\r\026 \f\r\017\013\026\ \023\030\016\n\024\005 \022\017\001\022\017, \016\r\035\016\035)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc 0.248 Tw T* (\f\016 \031\r\036\035\017\004\036\027\027\t\005 \017\027\007\036\022\f \n\ \026\f\f\t \021\036\035\026. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\021\030\024\036)Tj 0 Tc 0 Tw (-)Tj 0.002 Tc -0.002 Tw T* (\027\017\017 )Tj /T1_1 1 Tf -0.017 Tc 0.017 Tw 2.014 0 Td [(RO)-19(C)]TJ /T1_0 1 Tf 0.002 Tc 0.226 Tw 1.475 0 Td (-\022\030\017\r\024\005 \r\t\016\r\035\036\027\024, \004\021\024 \023\030\ \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\007\036\022\f\036 \n\026\f\f\t)2( )]TJ 0.202 Tw -3.489 -1.218 Td (\021\036\035\026)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC [(30,7 \022\020/\n\262 \r\024\030\026\f\021\026\036\021 \r\036\030\024\016\ \021\027\024\f\021\034 \r\024\r\030\026\021\026)2( )]TJ 0.016 Tw 23.244 25.574 Td (\026\002\024\035\036\r\026\027\017\016 \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,14; 95% \212\230 1,02; 1,29; )Tj /T1_1 1 Tf 0 Tc 0 Tw (\032)Tj /T1_0 1 Tf 0.002 Tc 0.016 Tw /Span<>> BDC 19.044 0 Td ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0,02\))2( )]TJ 0 Tw -19.044 -1.218 Td (\(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0 Tc -0.003 Tw T* (\025\030\024\n\036 \021\024\020\024, \f\021\026\021\017\f\021\017\004\036\ \f\022\017 \027\026\004\017\n\t\n\017 \235\026\022\021\024\030\026\n\017\ \030\017)Tj 0 Tw (-)Tj -0.062 Tw T* (\f\022\026 \030\026\r\017\021\017\016 \030\036\006\017\007\017\r\026 \f\ \r\017\013\026 \023\030\016\n\024\005 \022\017\001\022\017 \016\r\035\016\ \035\017\f\034 )Tj 0.074 Tw T* (\020\027\024\005\027\t\036 \026\021\036\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\n\036\032\f\235\017\027\022\021\036\030\027\024\n \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5,50 \(95% )Tj 0.141 Tw T* (\212\230 1,14; 26,6\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.141 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\), \017\001\017\024\026\027\026\035\034\027\024\n \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (16,8 )Tj 0.142 Tw T* (\(95% \212\230 3,20; 7,55\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.142 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0009)Tj /T1_1 1 Tf 0 Tw (\))Tj /T1_0 1 Tf 0.142 Tw ( \017)Tj /Span<>> BDC ( )Tj EMC (\023\036\035\034\r\017\024\030\036\022\021\026\035\034)Tj 0 Tw (-)Tj 0.145 Tw T* [(\027\024\n )0.5(\023\030\024\f\021\030\026\027\f\021\r\026\b )0.5(\(\210\231)]TJ /Span<>> BDC ( )Tj EMC 10.451 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(7,86 )0.5(\(95% )0.5(\212\230 )0.5(1,69; 36,6\), )]TJ /T1_1 1 Tf 0 Tw -10.451 -1.218 Td (\032)Tj /T1_0 1 Tf 0.134 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \017\b \022\024\n\002\017\027\026\006\017\016 \(\n\027\ \024\032\036\f\021\r\036\027\027\t\036 )Tj -0.003 Tw T* (\026\021\036\022\017\) \(\210\231)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4,40 \(95% \212\230 1,14; 16,9\), )Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.003 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\). \200)Tj /Span<>> BDC ( )Tj EMC (\021\024 )Tj -0.031 Tw T* [(\032\036 \r\030\036\n\016 \020\027\024\005\027\024-\r\024\f\023\026\035\017\ \021\036\035\034\027\t\036 )0.5(\024\004\026\020\017, \030\026\f\023\024\035\026\020\026\033)]TJ 0 Tw (-)Tj 0.055 Tw T* (\013\017\036\f\016 \030\036\021\030\024\030\036\022\021\026\035\034\027\024\ , \023\024\007\f\035\017\017\f\021\024 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\f\021\036\027\024\004)Tj 0 Tw (-)Tj T* (\027\024, \027\036 \031\b\031\007\001\026\035\017 \023\030\024\020\027\024\  \023\030\017\n\036\027\036\027\017\016 \214\215\214.)Tj 0.335 Tw T* (\222\021\024\017\021 \023\024\007\004\036\030\022\027\031\021\034, \004\021\ \024 \031)Tj /Span<>> BDC ( )Tj EMC (39/60 \(65,0%\) \002\024\035\034\027\t\b, )Tj 0.301 Tw T* (\r\022\035\033\004\036\027\027\t\b \r)Tj /Span<>> BDC ( )Tj EMC [(\017\f\f\035\036\007\024\r\026\027\017\036, \017\n\036\035\017\f\034 )0.5(\020\027\024\005\027\024-\r\024\f)]TJ 0 Tw (-)Tj 0.091 Tw T* (\023\026\035\017\021\036\035\034\027\t\036 \024\004\026\020\017 \(\026\021\ \036\022\017\), \031)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\020\024 \030\016\007\026 \023\026\006\017\036\027\021\024\r\ )Tj 0.282 Tw T* (\r\t\007\024\030\024\r\035\036\027\017\016 \031\007\026\035\024\f\034 \007\ \024\002\017\021\034\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (28/39 \(71,8%\) )Tj 0.039 Tw T* (\027\026\002\035\033\007\036\027\017\016\b. \200)Tj /Span<>> BDC ( )Tj EMC (23/39 \(59,0%\) \f\035\031\004\026\016\b \026\021\036\022\017 \017\n\036\ \035\017 )Tj -0.005 Tw T* (\n\027\024\032\036\f\021\r\036\027\027\t\005 \b\026\030\026\022\021\036\030\ , \023\024\f\035\036 \023\030\017\n\036\027\036\027\017\016 \023\030\036\ \007\035\024)Tj 0 Tw (-)Tj -0.025 Tw T* (\032\036\027\027\024\020\024 \n\036\021\024\007\026 \f\r\017\013 \031\007\ \026\035\024\f\034 \035\017\022\r\017\007\017\030\024\r\026\021\034 \031\ )Tj /Span<>> BDC ( )Tj EMC (15/23 )Tj 0.309 Tw T* (\(65,2%\) \023\026\006\017\036\027\021\024\r. \221\026\022\017\n \024\002\ \030\026\024\n, \007\026\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026)Tj 0 Tw (-)Tj 0.436 Tw T* (\035\017\004\017\017 \026\021\036\022\024\r, \f\021\026\021\017\f\021\017\ \004\036\f\022\017 \027\026\004\017\n\024 \r\035\017\016\033\013\017\b \ )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.076 Tw 9 0 0 9 70.8661 730.483 Tm [(\020\004\206\f\t\204\004 )0.6(7.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\217\006\027\025\n\020 )0.5(\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 )0.7(\024\031\024\023\031\t\025\022\t )0.6(\016\020\033\022\032\020\023\027\f\017\025\031\b\031 )0.6(\020\033\033\020\032\020\023\020 )0.6(\033\032\t\026\031\235 )0.5(\n\022\213\n\022 )0.5(\030\031)]TJ /Span<>> BDC ( )Tj EMC 39.6 0 Td (\022)Tj /Span<>> BDC ( )Tj EMC 0.807 0 Td [(\033\031\024\f\027 )0.6(\033\032\022\026\027\025\027\025\022\t )0.5(\033\027\032\027)]TJ 0 Tw (-)Tj -40.408 -1.2 Td (\026\027\212\027\025\025\031\b\031 \f\020\023\027\032\020\f\017\025\031\b\ \031 \033\032\t\026\031\n\022\213\027\007\025\031\b\031 \f\031\024\n\r\023\ \020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.076 Tc 0.076 Tw 0 -1.2 TD [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.25 0 Td [( A)-17.8(s)-10.5(s)0.5(e)-22(s)-10.5(s)5.1(m)-5.2(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5(na)-4.5(l s)4.4(p)-1.1(h)1.7(i)3.9(n)-2.9(c)-32.4(t)-1.6(e)-6(r f)-18(u)0.6(n)-2.9(c)-32.4(t)-29.1(i)-1.4(o)-4(n b)-10.1(ef)-13.4(o)-3(r)-2(e a)-5.1(n)-4.8(d af)-50.9(t)-1.6(e)-6(r l)-1.1(a)-9.2(t)-1.6(e)-5.9(r)3.3(a)-4.5(l r)-2(e)-10.9(c)-32.4(t)-2(a)-4.5(l \247)-66.8(a)-5.2(p r)-2(e)-7.7(p)-6.3(a)-6.3(i)4.9(r)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 704.381 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 365.9193 704.381 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 428.2815 704.381 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 490.6437 704.381 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 524.6594 683.5618 cm 0 0 m 0 20.569 l S Q q 1 0 0 1 70.8661 683.3118 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 683.3118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 683.3118 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 490.6437 683.3118 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 662.5005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 662.2505 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 662.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 662.2505 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 490.6437 662.2505 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 641.4392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 641.1892 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 71.1161 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 365.9193 641.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 365.9193 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 428.2815 641.1892 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 490.6437 641.1892 cm 0 0 m 34.266 0 l S Q q 1 0 0 1 490.6437 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 524.6594 620.3779 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 620.1279 cm 0 0 m 295.053 0 l S Q q 1 0 0 1 365.9193 620.1279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 428.2815 620.1279 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 490.6437 620.1279 cm 0 0 m 34.266 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 198.346 690.9464 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 22.063 0.6 Td (\031\002 \002\212\r\006\004\204\t\t)Tj 1.393 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj 5.648 1.2 Td (\200\002\217\f\r \002\212\r\006\004\204\t\t)Tj 2.147 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (46)Tj /T1_3 1 Tf 7.152 0.6 Td (\t)Tj /T1_0 1 Tf -53.953 -2.033 Td (\210\006\036\027\022\026 \023\024)Tj /Span<>> BDC ( )Tj EMC (\001\022\026\035\036 Wexner, \002\026\035\035\t, )Tj /T1_1 1 Tf (\215\027 \(Q1; Q3\))Tj T* (Min\231Max)Tj /T1_0 1 Tf 38.885 1.2 Td (1)Tj /Span<>> BDC ( )Tj EMC (\(0; 3\))Tj 0.48 -1.2 Td (0\22611)Tj 7.315 1.2 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(0; 3\))Tj 0.48 -1.2 Td (0\22612)Tj 6.209 1.2 Td (0,68)Tj -53.37 -2.633 Td (\222\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021, )Tj /T1_1 1 Tf (\215\027 \(Q1; Q3\))Tj T* (Min\231Max)Tj /T1_0 1 Tf 38.135 1.2 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(37; 40\))Tj 0.98 -1.2 Td (29\22650)Tj 6.815 1.2 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(36; 40\))Tj 0.98 -1.2 Td (27\22646)Tj 6.459 1.2 Td (0,86)Tj 7.52 0 0 8 73.9508 632.5626 Tm (\204\026\022\f\017\n\026\035\034\027\024\036 \007\026\r\035\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n \f\024\022\030\026\013\036\027\017\017, \n\n \030\ \021.)Tj /Span<>> BDC ( )Tj EMC (\f\021., )Tj /T1_1 1 Tf (\215\027 \(Q1; Q3\))Tj 8 0 0 8 73.9508 622.9626 Tm (Min\231Max)Tj /T1_0 1 Tf 37.043 1.2 Td (148,5)Tj /Span<>> BDC ( )Tj EMC (\(127; 169\))Tj 1.823 -1.2 Td (93\226236)Tj 5.972 1.2 Td (150,5)Tj /Span<>> BDC ( )Tj EMC (\(130; 164\))Tj 1.823 -1.2 Td (98\226224)Tj 6.709 1.2 Td (0,46)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 9 0 0 9 70.8661 603.4086 Tm (\020\004\206\f\t\204\004 8.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( \210\025\022\021\020\032\022\020\025\023\025\013\235 \020\025\020\f\022\ \016 \203\020\n\023\031\032\031\021, \033\032\027\030\033\031\f\031\255\022\ \023\027\f\017\025\031 \021\f)0.5(\022\t\005\212\022\200 \025\020)]TJ /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\027 \032\027\006\022\030\022\021\020 \205\004\ \202)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 8)-39.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0 Tw 3.339 0 Td [( U)7.5(n)1.7(i)-2.9(v)6.3(a)-4.2(r)-38.9(i)1.5(a)-9.2(t)-1.6(e a)-5.1(na)-4.5(l)6.7(y)-5.3(s)-12.5(i)6.6(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(f)-8.1(a)-9.1(c)-32.4(t)-3(o)-3(r)-14.9(s p)-9.1(o)-2.9(t)-1.6(e)-7(nt)-29.1(i)1.5(a)-4.5(l)-3.9(l)6.6(y i)3.9(n)9.3(\247)-65.7(u)-3.2(e)-6.9(n)-3(c)2.9(e)-12.9(d A)10(F r)-2(e)-10.9(c)-0.6(u)1.7(r)-19.5(r)-2(e)-7(n)-2.9(c)2.8(e)]TJ ET /GS2 gs q 1 0 0 1 70.8661 588.1067 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 195.8405 588.1067 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 588.1067 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 588.1067 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 576.8875 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 576.6375 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 195.8405 576.6375 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 576.6375 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 576.6375 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 565.4183 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 70.8661 565.1683 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 565.1683 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 565.1683 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 565.1683 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 553.957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 553.707 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 553.707 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 553.707 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 553.707 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 542.4957 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 542.2457 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 542.2457 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 542.2457 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 542.2457 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 531.0344 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 530.7844 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 530.7844 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 530.7844 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 530.7844 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 519.5731 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 519.3231 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 195.8405 519.3231 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 519.3231 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 519.3231 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 508.1118 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 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q 1 0 0 1 467.9665 462.0167 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 450.8054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 450.8054 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 450.5554 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 71.1161 439.0862 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 195.8405 450.5554 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 195.8405 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 450.5554 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 450.5554 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 439.3362 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 427.6249 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 195.5905 439.0862 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 427.8749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 439.0862 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 427.8749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 439.0862 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 427.8749 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 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393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 404.6944 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 404.6944 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 393.4752 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 381.756 cm 0 0 m 0 11.469 l S Q q 1 0 0 1 195.5905 393.2252 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 393.2252 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 467.9665 393.2252 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 524.6594 382.006 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 71.1161 370.2947 cm 0 0 m 0 11.461 l S Q q 1 0 0 1 195.5905 381.756 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 381.756 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 381.756 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 370.5447 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 71.1161 359.0834 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 195.5905 370.2947 cm 0 0 m 187.337 0 l S Q q 1 0 0 1 195.8405 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 370.2947 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 382.9272 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 467.9665 370.2947 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 467.9665 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 524.6594 359.0834 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 358.8334 cm 0 0 m 124.974 0 l S Q q 1 0 0 1 195.8405 358.8334 cm 0 0 m 187.087 0 l S Q q 1 0 0 1 382.9272 358.8334 cm 0 0 m 85.039 0 l S Q q 1 0 0 1 467.9665 358.8334 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 211.4378 579.4721 Tm (\203\004\220\003\002\006\013)Tj 23.752 0 Td (\017\016 \(95% \031\034\))Tj /T1_3 1 Tf 11.598 0.001 Td (\t)Tj /T1_0 1 Tf -52.536 -1.433 Td (\230\204\221, \022\020/\n)Tj 4.664 0 0 4.664 106.0864 570.6749 Tm 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2,76\))Tj 11.302 0 Td (0,69)Tj -51.953 -1.433 Td (\210\021\027\024\001\036\027\017\036 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 )Tj T* (\022)Tj /Span<>> BDC ( )Tj EMC (\n\t\001\006\026\n \027\026\030\031\032\027\024\020\024 \f\235\017\027\022\ \021\036\030\026)Tj 22.949 1.2 Td (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 )Tj 17.702 0 Td (0,53)Tj /Span<>> BDC ( )Tj EMC (\(0,06; 4,80\))Tj 11.302 0 Td (0,57)Tj -29.175 -1.433 Td (\233\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 17.873 0 Td (6,60)Tj /Span<>> BDC ( )Tj EMC (\(0,79; 55,5\))Tj 11.302 0 Td (0,08)Tj -51.953 -1.433 Td (\212\017\026\n\036\021\030 \200\222\210, \n\n)Tj 40.651 0 Td (0,96)Tj /Span<>> BDC ( )Tj EMC (\(0,59; 1,57\))Tj 11.302 0 Td (0,88)Tj -51.953 -1.433 Td (\203\026\035\017\004\017\036 \020\027\024\005\027\024-\r\024\f\023\026\035\ \017\021\036\035\034\027\t\b )Tj T* (\024\004\026\020\024\r \(\026\021\036\022\024\r\))Tj 21.019 1.2 Td (\204\027\024\032\036\f\021\r\036\027\027\t\036 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\026\021\036\022)Tj 18.627 0 Td (5,50)Tj /Span<>> BDC ( )Tj EMC (\(1,14; 26,6\))Tj /T1_2 1 Tf 11.162 -0.001 Td (0,03)Tj /T1_0 1 Tf -29.061 -1.433 Td (\215\024\007\f\035\017\017\f\021\t\005 \026\021\036\022)Tj 17.898 0 Td (4,27)Tj /Span<>> BDC ( )Tj EMC (\(0,25; 73,8\))Tj 11.302 0 Td (0,31)Tj -29.895 -1.433 Td (\200\027\031\021\030\017\f\021\036\027\024\004\027\t\005 \026\021\036\022\ )Tj 18.686 0 Td (9,40)Tj /Span<>> BDC ( )Tj EMC (\(0,77; 144\))Tj 11.209 0 Td (0,07)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1774 56.0378 Tm (76)Tj ET endstream endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj <> endobj 27 0 obj <> endobj 28 0 obj <> endobj 1243 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1244 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1245 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1246 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1247 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1254 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.427 Tw 10 0 0 10 42.5197 615.2279 Tm (\r\n\036\001\026\021\036\035\034\f\021\r\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\n\036\021 \f\024\f\021\024\016\021\036\035\034\027\024\f\ \021\017 \001\r\024\r )Tj 0.215 Tw 0 -1.218 TD [(\235\017\022\f\017\030\024\r\026\027\027\024\020\024 )0.5(\035\024\f\022\031\021\026 \017)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\t\b \024\f)Tj 0 Tw (-)Tj 0.173 Tw T* [(\035\024\032\027\036\027\017\005. )0.5(\215\026\035\034\006\036\r\024\036 \017\f\f\035\036\007\024\r\026\027\017\ \036 \023\030\016\n\024\005 )0.5(\022\017\001\022\017, )]TJ 0.064 Tw 0 -1.218 TD (\027\036 \023\030\024\r\024\007\017\035\024\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 1 \n\036\f\016\006\026 \023\024\f\035\036 \024\ \023\036\030\026\006\017\017, )Tj 0.148 Tw 0 -1.218 TD (\f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \f\027\017\032\036\027\017\016 \030\017\f\022\026 \024\ \002\030\026\021\027\024\020\024 \f\n\036\013\036\027\017\016 \235\017\022\ )Tj 0 Tw (-)Tj 0.174 Tw 0 -1.218 TD (\f\017\030\024\r\026\027\027\024\020\024 \035\024\f\022\031\021\026. \212\ \035\016 \024\006\036\027\022\017 \030\036\031\035\034\021\026\021\024\r\ \023\030\017)Tj 0 Tw (-)Tj 0.198 Tw T* (\n\036\027\036\027\017\016 \n\036\021\024\007\026 \214\215\214, \002\t\035\ \017 \024\002\024\027\026\004\036\027\t \023\036\030\r\017\004\027\t\036\ )Tj 0.215 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\r\021\024\030\017\004\027\t\036 \022\024\027\036\004\027\t\036 \021\024\ \004\022\017, \023\036\030\r\017\004\027\024\005 \022\024\027\036\004\027\ \024\005 )Tj -0.034 Tw T* (\021\024\004\022\024\005 \016\r\035\016\036\021\f\016 \004\026\f\021\024\ \021\026 \027\036 \027\026\f\021\031\023\035\036\027\017\016 \030\036\006\ \017\007\017\r\026 \026)Tj 0 Tw (-)Tj 0.021 Tw T* (\002\024\035\036\r\026\027\017\016 \(\220\235\235\036\022\021\017\r\027\024\ \f\021\034 \035\036\004\036\027\017\016\), \r\021\024\030\017\004\027\t\n\ \017)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.126 Tw T* (\024\006\036\027\022\026 \235\031\027\022\006\017\024\027\026\035\034\027\ \024\020\024 \f\024\f\021\024\016\027\017\016 \026\023\017\030\026\021\036\ \035\034\027\024\020\024 )Tj 0.403 Tw T* [(\026\023\023\026\030\026\021\026 \023\030\016\n\024\005 )0.5(\022\017\001\022\017; \r\t\030\026\032\036\027\027\024\f\021\017 \002\024\ \035\036\r\024\020\024 )]TJ 0.044 Tw T* (\f\017\027\007\030\024\n\026; \235\026\022\021\024\030\024\r \030\017\f\022\ \026, \023\030\036\007\023\024\035\024\032\017\021\036\035\034\027\024 \r\ \035\017\016)Tj 0 Tw (-)Tj T* (\033\013\017\b \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\017\021\017\036 \030\036\006\017\007\017\r\026.)Tj /T1_2 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_1 1 Tf -0.004 Tc 1.14 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\026\016 \024\002\030\026\002\ \024\021\022\026 \007\026\027\027\t\b \r\t\023\024\035\027\036\027\026)-4( )]TJ 0.154 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(RS)15(tudio \(R v. 4.4.1 \(R Cor)-24(e T)40(eam, V)-15(ienna, A)10(ustr)-37(ia\)\))-4( )]TJ 0.179 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC [(\023\030\017\n\036\027\036\027\017\036\n \002\017\002\035\017\024\021\036\ \022 base, g)17(tsummar)-24(y, ggpl)30(o)17.1(t2,)-4( )]TJ 0.08 Tw T* (pROC, ROCR \017)Tj /Span<>> BDC ( )Tj EMC [(GenBinomApps. \003\027\026\004\036\027\017\016 \022\026\004\036\f\021\r\036\ \027\027\t\b)-4( )]TJ 0.403 Tw T* (\027\024\n\017\027\026\035\034\027\t\b \023\030\017\027\026\022\024\r \023\ \030\017\r\024\007\017\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \026\002\f\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.095 Tw T* (\035\033\021\027\t\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\f\017\021\036\035\034\027\t\b \004\026\f\021\024\021 \(\ )Tj /T1_3 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf -0.004 Tc 0.095 Tw 14.483 0 Td ( \(%\) \017\035\017 )Tj /T1_3 1 Tf 0 Tc 0 Tw (n)Tj /T1_1 1 Tf -0.004 Tc 0.004 Tw 4.455 0 Td [(/N\(%\)\).)-4( )]TJ 0.279 Tw -18.937 -1.218 Td (\203\036\023\030\036\030\t\r\027\t\036 \017)Tj /Span<>> BDC ( )Tj EMC (\022\026\004\036\f\021\r\036\027\027\t\036 \023\024\030\016\007\022\024\r\ \t\036 \r\036\035\017\004\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.185 Tw T* (\027\t \(\023\030\017 \004\017\f\035\036 \027\026\004\036\027\017\005)Tj /Span<>> BDC ( )Tj EMC (\250)Tj /Span<>> BDC ( )Tj EMC [(5\) \024\023\017\f\t\r\026\035\017 \n\036\007\017\026\027\024\005,)-3.9( )]TJ 0.121 Tw T* (\027\017\032\027\017\n \017)Tj /Span<>> BDC ( )Tj EMC (\r\036\030\b\027\017\n \022\r\026\030\021\017\035\016\n\017 \(Me \(Q1; Q\ 3\)\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.191 Tw T* (\032\036 \030\026\n\026\b\024\n \(Min\226Max\). \222)Tj /Span<>> BDC ( )Tj EMC [(\006\036\035\034\033 \024\006\036\027\022\017 )0.5(\007\017\027\026\n\017\022\017)-4( )]TJ 0.247 Tw T* [(\017\n\036\027\036\027\017\016 \022\024\035\017\004\036\f\021\r\036\027\ \027\t\b \023\024\022\026\026\021\036\035\036\005 \023\030\017\n\036\027\ \016\035\017)-4( )]TJ 0.302 Tw T* [(\022\030\017\021\036\030\017\005 \211\017\035\022\024\022\f\024\027\026 \ \007\035\016 \f\r\016\026\027\027\t\b \020\030\031\023\023. \215\024\017\ \f\022)-4( )]TJ 0.324 Tw T* [(\235\026\022\021\024\030\024\r, \022\024\021\024\030\t\036 \n\024\020\035\ \017 \002\t \002\t\021\034 \026\f\f\024\006\017\017\030\024\r\026\027\t)-4( )]TJ 0.207 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\r\024\027\017\022\027\024\r\036\027\017\036\n \030\036\006\017\007\017\ \r\026, \024\f\031\013\036\f\021\r\035\016\035\017 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.22 Tw T* (\013\034\033 \031\027\017\r\026\030\017\026\027\021\027\024\020\024 \035\ \024\020\017\f\021\017\004\036\f\022\024\020\024 \030\036\020\030\036\f\f\ \017\024\027\027\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.087 Tw T* (\020\024 \026\027\026\035\017\026 \f)Tj /Span<>> BDC ( )Tj EMC [(\031\022\026\026\027\017\036\n \027\026\004\036\027\017\016 \024\021\027\ \024\001\036\027\017\016 \001\026\027\f\024\r)-4( )]TJ -0.033 Tw T* (\(\210\231\) \017)Tj /Span<>> BDC ( )Tj EMC (\036\020\024 95% \212\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \200\026\035\034\007\026. \212\035\016 \024\006\036\ \027\022\017 \r\035\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.034 Tw T* (\016\027\017\016 \022\024\035\017\004\036\f\021\r\036\027\027\024\005 \023\ \036\030\036\n\036\027\027\024\005 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\017\f\b\024\007 \023\030\024\r\036\007\036\027)-3.9( )]TJ /T1_3 1 Tf -0.023 Tc 0.023 Tw 0 -1.218 TD [(RO)-19(C)]TJ /T1_1 1 Tf -0.004 Tc 0.226 Tw 1.457 0 Td (-\026\027\026\035\017, \030\026\f\f\004\017\021\t\r\026\035\017 \023\035\ \024\013\026\007\034 \023\024\007 )Tj /T1_3 1 Tf -0.023 Tc 0.023 Tw [(RO)-19(C)]TJ /T1_1 1 Tf -0.004 Tc 0.004 Tw 17.352 0 Td [(-\022\030\017\r\024\005)-4( )]TJ 0.042 Tw -18.809 -1.218 Td [(\(A)17(UC\), \036\036 \f\021\026\027\007\026\030\021\027\024\036 \024\021\022\035\ \024\027\036\027\017\036, 95% \212\230 \017)]TJ /Span<>> BDC ( )Tj EMC [(\031\030\024\r\036\027\034)-4( )]TJ 0.369 Tw 0 -1.218 TD (\027\026\004\017\n\024\f\021\017. \210\021\030\036\027\031\033 \021\024\ \004\022\031 \024\023\030\036\007\036\035\016\035\017 \022\030\017\021\036\ \030\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.135 Tw T* [(\036\n \247\024\007\036\027\026; \007\035\016 \027\036\036 \030\026\f\f\004\ \017\021\t\r\026\035\017 \004\031\r\f\021\r\017\021\036\035\034\027\024\f\ \021\034,)-4( )]TJ 0.065 Tw T* (\f\023\036\006\017\235\017\004\027\024\f\021\034, \023\030\036\007\f\022\ \026\026\021\036\035\034\027\031\033 \006\036\027\027\024\f\021\034 \023\ \024\035\024\032\017)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc 0.006 Tw T* (\021\036\035\034\027\024\020\024 \030\036\031\035\034\021\026\021\026 \(\ \215\037\215\217\) \017)Tj /Span<>> BDC ( )Tj EMC (\023\030\036\007\f\022\026\026\021\036\035\034\027\031\033 \006\036\027\ )Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.036 Tw T* (\027\024\f\021\034 \024\021\030\017\006\026\021\036\035\034\027\024\020\024\ \030\036\031\035\034\021\026\021\026 \(\215\037\210\217\); \007\035\016\ \220\021\017\b \023\024)Tj 0 Tc 0 Tw (-)Tj -0.004 Tc -0.047 Tw T* (\022\026\026\021\036\035\036\005, \026)Tj /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 \007\035\016 \023\036\030\r\017\004\027\024\005 \021\ \024\004\022\017 \017\f\f\035\036\007\024\r\026\027\017\016)-4( )]TJ 0 Tw T* (\030\026\f\f\004\017\021\t\r\026\035\017 95% \212\230 \023\024)Tj /Span<>> BDC ( )Tj EMC (\n\036\021\024\007\031 \025\035\024\023\023\036\030\026\226\215\017\030\f\ \024\027\026.)Tj 0 Tc 1.255 Tw T* (\217\026\035\017\004\017\016 \f\004\017\021\026\035\017 \f\021\026\021\017\ \f\021\017\004\036\f\022\017 \027\026\004\017\n\t\n\017 )Tj 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_3 1 Tf (\032)Tj /T1_1 1 Tf /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 275.0305 615.2279 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.001 Tw 10 0 0 10 274.9606 590.8719 Tm (\212\035\017\021\036\035\034\027\024\f\021\034 \024\023\036\030\026\006\017\ \017 \f\024\f\021\026\r\035\016\035\026 \024\021 15 \007\024)Tj /Span<>> BDC ( )Tj EMC (95 \n\017\027\031\021 )Tj -0.012 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\036 \r)Tj /Span<>> BDC ( )Tj EMC (40 \(30; 50\) \n\017\027\031\021, \017\027\021\030\026\024\023\036\030\026\ \006\017\024\027\027\t\b )Tj 0 Tw T* (\024\f\035\024\032\027\036\027\017\005 \027\036 \026\235\017\022\f\017\030\ \024\r\026\027\024.)Tj 0.044 Tw T* (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \023\026\006\017\036\027\021\024\r \024\002\036\ \002\024\035\017)Tj 0 Tw (-)Tj 0.122 Tw T* (\r\026\035\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \023\030\036\023\026\030\026\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\t \027\036\f\021\036\030\024\017\007)Tj 0 Tw (-)Tj 0.205 Tw T* (\027\t\b \023\030\024\021\017\r\024\r\024\f\023\026\035\017\021\036\035\034\ \027\t\b \f\030\036\007\f\021\r, \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\027\026\004\036\027\017\017 )Tj 0.271 Tw T* (\027\026\030\022\024\021\017\004\036\f\022\017\b \026\027\026\035\034\020\ \036\021\017\022\024\r \027\036 \002\t\035\024 \027\036\024\002\b\024\007\ \017\n\024)Tj 0 Tw (-)Tj 0.152 Tw T* (\f\021\017. \204\036\007\017\026\027\026 \031\030\024\r\027\016 \002\024\ \035\036\r\024\020\024 \f\017\027\007\030\024\n\026 \027\036 \023\030\036\ \r\t)Tj 0 Tw (-)Tj 0.216 Tw T* (\001\026\035\026 3)Tj /Span<>> BDC ( )Tj EMC (\002\026\035\035\024\r \026)Tj /Span<>> BDC ( )Tj EMC (\r\036\f\034 \023\036\030\017\024\007 \027\026\002\035\033\007\036\027\017\ \016 \031)Tj /Span<>> BDC ( )Tj EMC (\r\f\036\b )Tj 0.326 Tw T* [(\023\026\006\017\036\027\021\024\r. )0.6(\204\026\022\f\017\n\026\035\034\027\026\016 )0.6(\017\027\021\036\027\f\017\r\027\024\f\021\034 )0.6(\002\024\035\036\r\024\020\024 )]TJ 0 Tw T* (\f\017\027\007\030\024\n\026 \027\026\002\035\033\007\026\035\026\f\034 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (2\2264)Tj /Span<>> BDC ( )Tj EMC (\f\031\021\022\017 \023\024\f\035\036 \024\023\036\030\026\006\017\017, \ )Tj 0.072 Tw T* (\004\021\024, \027\026\017\002\024\035\036\036 \r\036\030\024\016\021\027\ \024, \f\r\016\026\027\024 \f)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\r\t\n \026\022\021\024\n \007\036)Tj 0 Tw (-)Tj 0.06 Tw T* (\235\036\022\026\006\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017\024\007\036. \215\024\f\035\036 4-\t\b )Tj 0.165 Tw T* (\f\031\021\024\022 \023\024\f\035\036 \024\023\036\030\026\006\017\017 \017\ \027\021\036\027\f\017\r\027\024\f\021\034 \002\024\035\036\r\t\b \024\013\ \031)Tj 0 Tw (-)Tj 0.175 Tw T* (\013\036\027\017\005 \027\026\004\017\027\026\036\021 \026\022\021\017\r\ \027\024 \f\027\017\032\026\021\034\f\016, \026)Tj /Span<>> BDC ( )Tj EMC (\022 10-\n\031 \007\027\033 )Tj 0 Tw T* (\002\024\035\034 \023\030\026\022\021\017\004\036\f\022\017 \024\021\f\031\ \021\f\021\r\031\036\021 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0.086 Tw T* (\200 \023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\ \036\030\017\024\007\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (14-\036 \f\031\021\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (1/60 )Tj 0.136 Tw T* [(\(1,7%\) \027\026\002\035\033\007\036\027\017\017 )0.5(\026\235\017\022\f\017\030\024\r\026\027\026 \030\036\021\030\026\022\006\ \017\016 \035\026\021\036)]TJ 0 Tw (-)Tj 0.205 Tw T* (\030\026\035\034\027\024\020\024 \035\024\f\022\031\021\026, \023\026\006\ \017\036\027\021\031 \r\t\023\024\035\027\036\027\024 \023\030\024\r\036\ \007\036\027\017\036 )Tj 0 Tw T* (\035\017\020\026\021\031\030\t \r)Tj /Span<>> BDC ( )Tj EMC (\026\n\002\031\035\026\021\024\030\027\t\b \031\f\035\024\r\017\016\b.)Tj 0.096 Tw T* (\204\036\007\017\026\027\026 \022\024\035\017\004\036\f\021\r\026 \007\027\ \036\005, \023\030\024\r\036\007\036\027\027\t\b \023\026\006\017\036\027\ \021\026\n\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\021\026\006\017\024\027\026\030\036, \f\024\f\021\026\r\017\035\026 7\ \(6,0;8,5\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 6.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \004\031\n\020\016\020\023\027\f\022 \024\203\022\025\n\023\027\032\031\ \026\027\023\032\022\022 \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021, \021\n\f\005\007\027\025\025\013\200\ \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027, \030\031)Tj /Span<>> BDC ( )Tj EMC (\031\033\027\032\020\023\022\021\025\031\b\031 \021\026\027\213\020\023\027\ \f\017\024\023\021\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 6)-29.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.002 Tc -0.002 Tw 3.329 0 Td [( S)11.1(p)0.9(h)3.7(i)5.9(n)-0.9(c)-30.4(te)-3.9(ro)-2(m)-3.3(e)-6.6(t)-7.6(r)-41.8(y)2( p)-4.3(a)-2.2(r)5.4(a)-3.1(m)-3.3(e)-6.6(te)-4(r)-12.9(s)2( b)-8.1(e)1.9(f)-11.3(o)-1(re)2( s)8.7(u)3.6(rg)-4.8(e)-4(r)-41.8(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 42.7697 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 246.8642 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 703.7117 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 371.5886 715.181 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 715.181 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.7697 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 309.2264 692.4926 cm 0 0 m 0 11.219 l S Q q 1 0 0 1 371.3386 703.7117 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 371.5886 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 433.9508 703.7117 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 692.4926 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 692.2426 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 42.7697 680.7812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 692.2426 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 692.2426 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 692.2426 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 681.0312 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 692.2426 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 680.7812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 680.7812 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 669.5699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 680.7812 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 246.8642 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 680.7812 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 309.2264 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 669.5699 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.5699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 669.5699 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 669.3199 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 42.7697 657.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.8642 669.3199 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 246.8642 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 669.3199 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 669.3199 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 658.1087 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 669.3199 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 433.9508 657.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 657.8587 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.7697 646.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 246.6142 657.8587 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 246.8642 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 309.2264 657.8587 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 309.2264 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 371.5886 646.6474 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 433.9508 646.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 496.313 646.6474 cm 0 0 m 0 11.211 l S Q q 1 0 0 1 42.5197 646.3974 cm 0 0 m 204.344 0 l S Q q 1 0 0 1 246.8642 646.3974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 309.2264 646.3974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 371.5886 646.3974 cm 0 0 m 62.362 0 l S Q q 1 0 0 1 433.9508 646.3974 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_5 1 Tf 0 Tc 0 Tw 8 0 0 8 104.3951 700.8117 Tm (\200\002\220\004\213\004\003\r\f\t \240\004\f\r\b\t\235 )Tj /Span<>> BDC ( )Tj EMC (\004\b\004\f\001\b\002\214 \220\004\b\004\f\r)Tj 28.106 0.6 Td (\025\002\006\214\004)Tj -0.995 -1.2 Td (\(min\232max\))Tj 7.991 1.317 Td (\034\217\217\f\r\240\210\r\214\004\235 \n\006\210\212\212\004, N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj -0.38 -1.434 Td (\215\r \(Q1; Q3\))Tj 8.498 0 Td (Min\232Max)Tj /T1_1 1 Tf -50.568 -1.433 Td (\222\030\036\007\027\036\036 \007\026\r\035\036\027\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\024\036, \n\n \030\021.\f\021.)Tj 26.998 0 Td (\240\036\027\013\017\027\t)Tj 8.574 0 Td (41\22663)Tj 6.815 0 Td (38)Tj /Span<>> BDC ( )Tj EMC (\(37; 40\))Tj 8.776 0 Td (29\22650)Tj -24.05 -1.433 Td (\204\031\032\004\017\027\t)Tj 8.46 0 Td (43\22661)Tj -35.572 -1.433 Td (\204\026\022\f\017\n\026\035\034\027\024\036 \007\026\r\035\036\027\017\036\ \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n \022\026\027\026\035\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\024\035\036\r\024\n )Tj T* (\f\024\022\030\026\013\036\027\017\017, \n\n \030\021.\f\021.)Tj 26.998 1.2 Td (\240\036\027\013\017\027\t)Tj 8.074 0 Td (110\226178)Tj 6.222 0 Td (148,5)Tj /Span<>> BDC ( )Tj EMC (\(127; 169\))Tj 9.618 0 Td (93\226236)Tj -23.8 -1.433 Td (\204\031\032\004\017\027\t)Tj 7.96 0 Td (121\226227)Tj ET q /GS0 gs 221.1023475 0 0 192.5342954 274.9606228 122.6196675 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.008 Tw 9 0 0 9 274.9606 111.7701 Tm (\022\t\217\210\b\002\220 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \220\022\025\020\026\022\n\020 \r\032\031\021\025\t \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020 \033\031\024\f\027 \031\033\027)Tj 0 Tw (-)Tj T* (\032\020\006\022\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\211\003\237 \021)Tj /Span<>> BDC ( )Tj EMC (\023\027\007\027\025\022\027 10 \030\025\027\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0.034 Tw T* [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf [( P)18(ain scores \(according to the Visual Analogue Scale, )]TJ 0 Tw T* [(V)42(A)50(S\) for 10 d)26.1(ays in postoperativ)13.1(e per)-36.9(iod)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.8394 56.0378 Tm (75)Tj ET endstream endobj 1255 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""   &_5Ert!"12AQTU #$%&'()*346789:BCDFGHIJRSVaWXYZbcdefghijqsuvwxyzk!A1a24Qq#3rѲ "$%&'()*56789:BCDEFGHIJRSTUVWXYZbcdefghijstuvwxyz? 9AjVy<0ⴉi0QE ))v?^aه,#.;0rd~?άvr7~?fLGß3ӳY&G#\va<X;0rd~?fLGՀӳX#.;0rd~?ζ=1;0rd~?fLGՀӳY&G#\va<ߑ:(C{0rd~?fLGՀӳY&G#\va<X;0o9gs[Öyɑr92?V;N9gqه,~G#\̡xÖyɑr92?V;N9gqه,#.u`Öyɑr92?Xw;>9gqه,#.u`Öyɑr92?V;N9g?Y&G#\biه,#.;0rd~?άvr92?YGՙx\va<9gsfLGÖyɑ:va<ߑr92?ZEbva<9gsfLGÖ?Y%va<9gs<Ġ,(i(V_6rI-~;+Ev;((w"7$jf=uX 2˽v>Ъv:ک;8CaqEv(*P&'\ MND%~7|j~Zj{g^s5v(k }S6IL_]( ҪP:єu#;}C꟯FQ:P|LQ왉{&bV9/YQs I_Bd/}}yؽ y(q@1|EﰳQg\H, /[Luod1p,p(6K| 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Htln)9H򟃘čU|{aItڂT{6xS$X9"ǘmeoA[%f=uX 2˽v>c$c&Z.۔|ժwdV9[,P q+V5ik܍J]lx2HluZSvR״\(Ԝ;]C꟯FQ6b*U~ CsrK.rIbY,2JrI$3GIy2l9gOtkK\S9UYf8bmD̞I-P(F(+Қ?9(+Қ?9ny k'gƟTGk_|P\< |LPjMQzLtaHd̲C,$dl(bQZy$3  In$7;81$)w4.r7rꘀQ˹w_IuGrꘀ ݼ_cܻ=1˹w_IuGrꘀ uT+6旤,^˺K;uTeܻw_IuL@jW`8]]P/}}y]˺K;uTeܻ,$YR#ܕw1yr}%1w..]]S&'Zլ;(9r9r{y8ukHN)Njrg[,}sܻw_IuL@]˺KeqC}ġ4βyy-VKQ-mlOMҴN% jRO1..?F!jsTɚMznnIfr̶bVgekj(g'$cL6pM<3fr'YG.G4Xƥ .PW)4"sPW)4"sЕ,Oύ>&I5P(5S׭}B1(+Қ?9U\)3NE?ɐI$2K&ƍ]_[# jaY3ll2k}dsZ6 +8"j8 P’R3"kBj8&(XsHA֙|nSK&9|t1x\6QanrI:=ÛLގ)No7%dqE9CVvn졅ĜT&yɖesn%h\9%1* =`),I-s[e=vkU!C[Y9}$Xʮ“8TWfޗ:t{%yYQEg QEgeE)C5)MeMuHKc\.tKI9ib),E,˘/TtqR4Ze^8vpNdPܫq9A0jrMM*'Hb,ŬIfIeE.JeYFVvN+ɩ3Ԧga{S|m]SvMi MYu&Plrjf.3sqI6 $ʹ#$Rl$$]8RJnJt[IIKp_#n+TuSY;VR.N,ۣ(m;'Z\w5Ǔ;[TBe ]Gϱ֪Q'*)+82G أp4)ruR⃲=JҏߤXw#Zɐ-mofŭ-x&L-U:u-2XPAn;JIb]W~#Pө%[kqDrm8u(!wdܧ$A;#ԯ=(GRV;N+J?~(;#ԯ=(GՒr (m;8-TqK[''(SsI7T3S2k{KRVm'Mp9iR↍U|;<04V* 4QbQILvG^zQAyG?vW~#Poc Qjյs&&\b.x4*m&TY4y=IoC6Q8]Iz)8W~#PvG^zQCdzHW~#PsdVT bQiuʥq5jRnQ"HեK[V1뉸{(U0Rs;#ԯ=(GRV;N+J?~(n3S-TXE -)C;NΈNSr*ȭ)(Օ8;;E5e (sjR⃲=JҏߤX;#ԯ=(GRV;k,R- jN88X)қzŜj~ZYŪm8ⅸrX[SO\x3Vdy>YFXibS$8~O.Uo`I''JN+J?~(;#ԯ=(GՀӲ=Jҏߤ+J?~(uf vx(=0(LA^n)Ɣ͒NQ,ѫ=Jҏߤf&ɲ2X"a5Rt ^vG^zQAyG?vW~#P7SOgN8+%pPpU5#'>(d'Yk7VڔQNER⃲=JҏߤX;#ԯ=(GRV;=LKkUA8bɢQ]W!;Nq{#ԯ=(G'&ԬR-r_7 !\7QC$t@dzHW~#PdY K[K2ٳfʼnlX`;N+J?~(nu7S2{;(5RV$K''iDtiڝaX7~8m`ʬ i(W' ;ңI$l=Jҏߤ+J?~(5c""';8-zݤWGfvEvyu`Kc9>QclF8m,)J)sLdu}9NY;EpΎq20תvv~'Rjp9DrfvMvYZ9Gf1)95 nQ[eV+KH8snTU5rM4ӣYnŗ-GGm*IDinT5i+5PFqBr jn[}[ZXYG,*OmSY=qZFPY($ejtpCmr8mlpZ P6Ӫk}9˲}O {);8lvNPCz'z3rIPYEN'Pc';+xaJŤ⢾:ͬkqr><יG;Qq#rQp[e6ڥOZ((jq;' Pi:NH%5&l [qCFxpz:Ş6%;X&B1)Ѯqi6&ۉv8"q(n(mVums NPMfheqZEqQMͶx@\)]Q7 ;oYfRwhN;n4 ൴QCqBpBM *5ܢ;hHNK24Ъ endstream endobj 1256 0 obj <>stream endstream endobj 1253 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.005 Tw 10 0 0 10 70.8661 128.1078 Tm [(\217\006\027\025\n\020 )0.5(\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 )0.5(\024\031\024\023\031\t\025\022\t )0.5(\016\020\033\022\032\020\023\027\f\017\025\031\b\031 )]TJ 0 Tw 0 -1.218 TD (\020\033\033\020\032\020\023\020 \033\032\t\026\031\235 \n\022\213\n\022\ )Tj /T1_1 1 Tf 0.105 Tw T* (\215\024 \007\026\027\027\t\n \f\235\017\027\022\021\036\030\024\n\036\021\ \030\017\017 \031)Tj /Span<>> BDC ( )Tj EMC (49/60 \(81,7%\) \023\026\006\017)Tj 0 Tw (-)Tj 0.023 Tw T* [(\036\027\021\024\r, )0.5(\r\022\035\033\004\036\027\027\t\b )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 8.861 0 Td [(\017\f\f\035\036\007\024\r\026\027\017\036, )0.6(\027\026)]TJ /Span<>> BDC ( )Tj EMC 7.432 0 Td (\007\024\024\023\036\030\026\006\017\024\027)Tj 0 Tw (-)Tj 0.086 Tw -16.293 -1.218 Td (\027\024\n \220\021\026\023\036 \r\t\016\r\035\036\027\024 \f\027\017\032\ \036\027\017\036 \007\026\r\035\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\035\034\027\024\n )Tj 0.066 Tw 23.244 64.543 Td (\022\026\027\026\035\036, \f\024\024\021\r\036\021\f\021\r\031\033\013\036\ \036 1 \f\021\036\023\036\027\017 \027\036\007\024\f\021\026\021\024\004\ \027\024\f\021\017 )Tj 0.047 Tw T* (\026\027\026\035\034\027\024\020\024 \f\235\017\027\022\021\036\030\026.\ \222\035\036\007\031\036\021 \024\021\n\036\021\017\021\034, \004\021\024\ \027\017 \r)Tj /Span<>> BDC ( )Tj EMC (\024\007)Tj 0 Tw (-)Tj 0.2 Tw T* (\027\024\n \f\035\031\004\026\036 \r)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\005 \020\030\031\023\023\036 \023\026\006\017\036\027\021\024\ \r \027\036 \002\t\035\024 \022\035\017)Tj 0 Tw (-)Tj 0.489 Tw T* [(\027\017\004\036\f\022\017\b )0.5(\023\030\024\016\r\035\036\027\017\005 )0.6(\027\036\007\024\f\021\026\021\024\004\027\024\f\021\017 )0.6(\026\027\026\035\034\027\024\020\024 )]TJ 0.003 Tw T* (\f\235\017\027\022\021\036\030\026. \200)Tj /Span<>> BDC ( )Tj EMC (3/60 \(5,0%\) \027\026\002\035\033\007\036\027\017\016\b \r\t\016\r\035\036\ \027\026 \027\036)Tj 0 Tw (-)Tj -0.005 Tw T* (\007\024\f\021\026\021\024\004\027\024\f\021\034 \026\027\026\035\034\027\ \024\020\024 \f\235\017\027\022\021\036\030\026 2 \f\021\036\023\036\027\ \017, \f)Tj /Span<>> BDC ( )Tj EMC (\022\035\017)Tj 0 Tw (-)Tj 0.154 Tw T* [(\027\017\004\036\f\022\017\n\017 )0.6(\023\030\024\016\r\035\036\027\017\016\n\017 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 12.085 0 Td [(\r\017\007\036 )0.5(\027\036\007\036\030\032\026\027\017\016 )0.6(\020\026\024\r )]TJ 0 Tw -12.085 -1.218 Td (\017)Tj /Span<>> BDC ( )Tj EMC (\032\017\007\022\024\020\024 \022\017\001\036\004\027\024\020\024 \f\024\ \007\036\030\032\017\n\024\020\024 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (6\).)Tj 0.06 Tw T* (\215\030\017 \024\006\036\027\022\036 \235\031\027\022\006\017\017 \007\036\ \030\032\026\027\017\016 \022\017\001\036\004\027\024\020\024 \f\024\007\ \036\030\032\017)Tj 0 Tw (-)Tj 0.244 Tw 0 -1.218 TD (\n\024\020\024 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\017 \001\022\026\035\t \026\027\026\035\034\027\024\005\ \017\027\022\024\027\021\017\027\036\027\006\017\017 )Tj 0.162 Tw 0 -1.218 TD [(W)22(e)-18(xner \r)]TJ /Span<>> BDC ( )Tj EMC (\023\030\036\007\024\023\036\030\026\006\017\024\027\027\024\n \023\036\030\ \017\024\007\036 \002\026\035\035\t \r\026\030\034\017)Tj 0 Tw (-)Tj 0 -1.218 TD (\030\024\r\026\035\017 \024\021 0 \007\024)Tj /Span<>> BDC ( )Tj EMC (11, \026)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\026 \f\024\f\021\026\r\017\035\026 1 \(0; 3\) \002\ \026\035\035.)Tj /T1_0 1 Tf 0.12 Tw 0 -2.436 TD (\027\200\025\022\n\020 \031\033\027\032\020\006\022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\021\027\030\027\025\022\027 \033\020\006\022\027\025\023\031\021 \021)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027)Tj 0 Tw (-)Tj 0 -1.218 TD (\032\020\006\022\031\025\025\031\026 \033\027\032\022\031\030\027)Tj /T1_1 1 Tf 0.758 Tw 0 -1.218 TD (\216\017\030\031\030\020\017\004\036\f\022\024\036 \r\n\036\001\026\021\036\ \035\034\f\021\r\024 \r\t\023\024\035\027\016\036\021\f\016 \023\024\007\ )Tj 0.211 Tw 0 -1.218 TD (\f\023\017\027\026\035\034\027\024)Tj /Span<>> BDC (\005)Tj EMC ( \026\027\036\f\021\036\017\036)Tj /Span<>> BDC (\005)Tj EMC ( \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\035\024\032\036\027\017\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (\f\023\017\027\036 \022\026\022 )Tj 0.309 Tw 0 -1.218 TD (\007\035\016 \035\017\021\024\021\024\n\017\017. \215\024\f\035\036 \026\ \027\021\017\f\036\023\021\017\004\036\f\022\024\005 \024\002\030\026\002\ \024\021\022\017 )Tj 0.083 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\030\036\r\017\017\017 \023\036\030\017\026\027\026\035\034\027\024\005\ \024\002\035\026\f\021\017, \026\027\026\035\034\027\024\020\024 \022\026\ \027\026\035\026, )Tj 0.047 Tw 0 -1.218 TD (\024\027\007\017\030\024\r\026\027\017\016, \023\030\024\022\030\026\001\ \017\r\026\027\017\016 \022\030\026\f\017\021\036\035\036\n \f\r\017\013\ \036\r\024)Tj 0 Tw (-)Tj -0.033 Tw 0 -1.218 TD (\020\024 \b\024\007\026 \017)Tj /Span<>> BDC ( )Tj EMC (\020\027\024\005\027\t\b \023\024\035\024\f\021\036\005 \r\t\023\024\035\ \027\016\036\021\f\016 \023\036\030\r\t\005 \220\021\026\023 )Tj 0.035 Tw T* (\024\023\036\030\026\021\017\r\027\024\020\024 \r\n\036\001\026\021\036\035\ \034\f\021\r\026)Tj /Span<>> BDC ( )Tj EMC (\227 \017\f\f\036\004\036\027\017\036 \f\r\017\013\036\r\024)Tj 0 Tw (-)Tj 0.01 Tw T* (\020\024 \b\024\007\026 \007\024)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 \f\021\036\027\022\017, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \r\f\022\030\t\021\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\007\030\036)Tj 0 Tw (-)Tj 0.099 Tw T* [(\027\017\030\024\r\026\027\017\036 )0.6(\020\027\024\005\027\024-\r\024\f\023\026\035\017\021\036\035\034\027\t\b\ )0.6(\024\004\026\020\024\r )0.5(\(\026\021\036\022\024\r\) )]TJ 0 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\b \027\026\035\017\004\017\017.)Tj 0.122 Tw T* (\200\021\024\030\t\n \220\021\026\023\024\n \r\t\023\024\035\027\016\036\ \021\f\016 \023\035\026\f\021\017\004\036\f\022\024\036 \026\022\030\t\021\ \017\036 )Tj 0.237 Tw T* [(\r\027\031\021\030\036\027\027\036\020\024 )0.6(\f\r\017\013\036\r\024\020\024 )0.5(\024\021\r\036\030\f\021\017\016 )0.6(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 17.084 0 Td [(\023\024\n\024\013\017 )0.5(\035\026)]TJ 0 Tw (-)Tj 0.221 Tw -17.084 -1.218 Td (\021\036\030\026\035\034\027\024\020\024 \023\030\016\n\024\022\017\001\036\ \004\027\024\020\024 \035\024\f\022\031\021\026. \215\024\f\035\036 \020\ \017\007\030\024)Tj 0 Tw (-)Tj 0.335 Tw T* (\023\030\036\023\026\030\024\r\022\017 \023\024\007\f\035\017\017\f\021\ \024\020\024 \f\035\024\016 \f\021\036\027\022\017 \026\027\026\035\034\027\ \024\020\024 )Tj 0.103 Tw T* (\022\026\027\026\035\026 \017)Tj /Span<>> BDC ( )Tj EMC (\007\017\f\021\026\035\034\027\024\020\024 \024\021\007\036\035\026 \027\ \017\032\027\036\026\n\023\031\035\016\030\027\024\020\024 \024\021)Tj 0 Tw (-)Tj 0.101 Tw T* (\007\036\035\026 \023\030\016\n\024\005 \022\017\001\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\036\022\006\017\017 \r\027\031\021\030\036\027\027\036\020\024\ \f\r\017\013\036)Tj 0 Tw (-)Tj 0.143 Tw 0 -1.218 TD (\r\024\020\024 \024\021\r\036\030\f\021\017\016, \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 \n\024\002\017\035\017\026\006\017\017 \035\026\021\ \036\030\026\035\034\027\024\020\024 )Tj 0.276 Tw 0 -1.218 TD (\f\035\017\017\f\021\024-\023\024\007\f\035\017\017\f\021\024\020\024 \ \035\024\f\022\031\021\026 \024\f\021\030\t\n \023\031\021\036\n \r\t)Tj 0 Tw (-)Tj 0.358 Tw 0 -1.218 TD (\023\024\035\027\016\036\021\f\016 \007\031\020\024\024\002\030\026\027\ \t\005 \030\026\030\036 \026\027\024\007\036\030\n\t. \212\026\035\036\ \036 )Tj 0.349 Tw T* [(\021\030\026\027\f\026\027\026\035\034\027\t\n )0.5(\007\024\f\021\031\023\024\n, \024\021 \f\r\017\013\036\r\024\020\024 \024\ \021\r\036\030\f\021\017\016 )]TJ -0.023 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\016\n\024\005 \022\017\001\022\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\022\024\r\024\n \027\026\023\030\026\r\035\036\027\017\017, \n\024\ \002\017\035\017\031\036\021)Tj 0 Tw (-)Tj -0.016 Tw T* [(\f\016 \f\035\017\017\f\021\024-\023\024\007\f\035\017\017\f\021\t\005\ )0.5(\035\024\f\022\031\021 \f\021\036\027\022\017 \027\017\032\027\036\026\n\ \023\031)]TJ 0 Tw (-)Tj 0.035 Tw T* (\035\016\030\027\024\020\024 \024\021\007\036\035\026 \023\030\016\n\024\ \005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\022\026\r\036\030\027\024\027\024\005 \021\022\026\027\034\033 )Tj 0.054 Tw T* (\(\002\035\017\032\026\005\001\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \024\023\036\030\026\006\017\017 \r\027\031\021\030\036\027\ \027\017\005 \020\036\n\024\030\030\024\017)Tj 0 Tw (-)Tj 0.111 Tw T* (\007\026\035\034\027\t\005 \031\036\035\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\036\036 \027\026\035\017\004\017\017. \215\030\024\017\r\024\007\017\021\ \f\016 \022\030\026\005)Tj 0 Tw (-)Tj 0.085 Tw T* (\027\036 \220\022\024\027\024\n\027\024\036 \017\f\f\036\004\036\027\017\ \036 \023\026\021\024\035\024\020\017\004\036\f\022\017 \017\n\036\027\036\ \027\027\t\b )Tj 0.012 Tw T* (\021\022\026\027\036\005 \r)Tj /Span<>> BDC ( )Tj EMC [(\024\002\035\026\f\021\017 \253\f\022\036\035\036\021\017\017\030\024\r\ \026\027\027\024\020\024\273 )0.5(\r\027\031\021\030\036\027\027\036\020\024 )]TJ T* [(\f\r\017\013\036\r\024\020\024 \024\021\r\036\030\f\021\017\016, )0.5(\035\017\002\024 )0.5(\036\020\024 \022\033\030\036\021\026\032, )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\007\031\033)Tj 0 Tw (-)Tj 0.091 Tw T* (\013\017\n \036\020\024 \031\001\017\r\026\027\017\036\n. \212\026\035\036\ \036 \f\235\024\030\n\017\030\024\r\026\027\027\t\005 \035\024\f\022\031\ \021 )Tj 0.043 Tw T* (\f\n\036\013\026\036\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027\031 \f\r\017\013\036\r\024\020\024 \024\021\r\036\ \030\f\021\017\016, \026\022\030\t\r\026\016 )Tj 0.066 Tw T* [(\036\020\024. )0.5(\003\026\021\036\n )0.5(\023\030\024\017\r\024\007\017\021\f\016 )0.6(\235\017\022\f\026\006\017\016 )0.6(\022\030\026\016 )0.5(\023\036\030\036\n\036\013\036\027)]TJ 0 Tw (-)Tj 0 -1.218 TD (\027\024\020\024 \035\024\f\022\031\021\026 \022)Tj /Span<>> BDC ( )Tj EMC (\022\030\026\033 \f\235\024\030\n\017\030\024\r\026\027\027\024\005 \030\ \026\027\t.)Tj 0.298 Tw 0 -1.218 TD (\200 \023\036\030\r\t\036 \f\031\021\022\017 \023\024\f\035\036 \b\017\030\ \031\030\020\017\004\036\f\022\024\020\024 \r\n\036\001\026\021\036\035\034\ )Tj 0 Tw (-)Tj 0.257 Tw 0 -1.218 TD [(\f\021\r\026 )0.5(\023\024\f\021\036\035\034\027\t\005 )0.6(\030\036\032\017\n )0.5(\023\026\006\017\036\027\021\026\n )0.6(\027\036 )0.5(\027\026\027\026\004\026\035\f\016. )]TJ 0.284 Tw 0 -1.218 TD (\203\026\004\017\027\026\016 \f\024 \r\021\024\030\t\b \f\031\021\024\022\ , \023\026\006\017\036\027\021\t \023\036\030\036\r\024\007\017\035\017\f\ \034 )Tj 0.225 Tw 0 -1.218 TD (\027\026)Tj /Span<>> BDC ( )Tj EMC (\024\002\013\017\005 \002\024\035\034\027\017\004\027\t\005 \030\036\032\ \017\n, \026)Tj /Span<>> BDC ( )Tj EMC (\017\f\022\035\033\004\036\027\017\036\n \026)Tj 0 Tw (-)Tj 0.091 Tw 0 -1.218 TD (\027\016\021\017\016 \023\024\035\024\032\036\027\017\016 \f\017\007\016\ . \200)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036\024\023\036\030\026\006\017\024\027\027\024\n \023\036\ \030\017)Tj 0 Tw (-)Tj 0.223 Tw 0 -1.218 TD (\024\007\036 \023\026\006\017\036\027\021\026\n \036\032\036\007\027\036\ \r\027\024 \r\t\023\024\035\027\016\035\017\f\034 \023\036\030\036\r\016\ \022\017, )Tj -0.013 Tw 0 -1.218 TD (\r\022\035\033\004\026\r\001\017\036 \024\006\036\027\022\031 \f\024\f\021\ \024\016\027\017\016 \024\002\035\026\f\021\017 \024\023\036\030\026\021\ \017\r\027\024\020\024 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.145 Tw 9 0 0 9 70.8661 730.483 Tm (\020\004\206\f\t\204\004 3.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \202\f\022\025\022\007\027\024\n\020\t \200\020\032\020\n\023\027\032\022\ \024\023\022\n\020 \033\020\006\022\027\025\023\031\021, \021\031)Tj 0 Tw (-)Tj 0 -1.2 TD (\213\027\030\213\022\200 \021)Tj /Span<>> BDC ( )Tj EMC (\022\024\024\f\027\030\031\021\020\025\022\027)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.463 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 3)-18.7(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.436 Tw 3.754 0 Td [( C)1.2(li)3.9(n)1.7(i)-1.8(c)3.2(a)-4.5(l c)-2.4(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-9.2(t)-29.1(i)-1.4(e)-7(n)-0.6(t)-32.9(s i)3.9(n)-2.9(c)-1.1(lu)-5.9(d)-5.2(e)-12.9(d i)3.9(n )]TJ 0 Tw -3.754 -1.2 Td [(t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.1(y)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 70.8661 693.5811 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 653.5618 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 229.8563 693.5811 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 653.5618 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 292.2185 653.5618 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 653.3118 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 622.9006 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 653.3118 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 622.9006 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 292.2185 622.9006 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 622.6506 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 601.8393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 229.8563 622.6506 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 601.8393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 601.8393 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 601.5893 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 580.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 229.8563 601.5893 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 580.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 292.2185 580.778 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 70.8661 580.528 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 550.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 229.8563 580.528 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 550.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 292.2185 550.1167 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 70.8661 549.8667 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 538.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 549.8667 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 538.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 538.6554 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 538.4054 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 527.1942 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 538.4054 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 527.1942 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 527.1942 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 526.9442 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 526.9442 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 130.3145 670.5464 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 13.178 1.8 Td (\026\217\r \212\004\204\t\r\b\003\013, )Tj 0.384 -1.2 Td (\220\f\211\201\r\b\b\013\r )Tj -0.655 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r)Tj 2.046 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj /T1_1 1 Tf -21.998 -1.433 Td (\215\024\035)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\240\036\027\f\022\017\005)Tj T* (\204\031\032\f\022\024\005)Tj 20.114 1.2 Td (32)Tj /Span<>> BDC ( )Tj EMC (\(53,3%\))Tj T* (28)Tj /Span<>> BDC ( )Tj EMC (\(46,7%\))Tj -21.177 -1.433 Td (\200\024\030\026\f\021, \035\036\021, )Tj /T1_0 1 Tf (Me \(Q1; Q3\))Tj 0 -1.2 TD (Min\231Max)Tj /T1_1 1 Tf 20.1 1.2 Td (46,5)Tj /Span<>> BDC ( )Tj EMC (\(39,0; 55,5\))Tj 2.008 -1.2 Td (32\22666)Tj -22.108 -1.433 Td (\230\204\221, \022\020/\n)Tj 4.664 0 0 4.664 106.0864 595.6266 Tm (2)Tj 8 0 0 8 108.4184 592.9626 Tm (, )Tj /T1_0 1 Tf (Me \(Q1; Q3\))Tj -4.308 -1.2 Td (Min\231Max)Tj /T1_1 1 Tf 20.1 1.2 Td (27,3)Tj /Span<>> BDC ( )Tj EMC (\(24,9; 31,1\))Tj 1.323 -1.2 Td (18,9\22640,6)Tj -21.423 -1.433 Td (\215\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \026\ \002\024\035\036\r\026\027\017\016, \n\036\f\016\006\t, )Tj /T1_0 1 Tf (Me )Tj 0 -1.2 TD (\(Q1; Q3\))Tj T* (Min\231Max)Tj /T1_1 1 Tf 21.627 1.2 Td (7)Tj /Span<>> BDC ( )Tj EMC (\(4; 13\))Tj 0.48 -1.2 Td (1\226112)Tj -22.108 -1.433 Td (\217\036\006\017\007\017\r\027\t\005 \b\026\030\026\022\021\036\030 \f\r\ \017\013\026)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj 21.177 0 Td (10)Tj /Span<>> BDC ( )Tj EMC (\(16,7%\))Tj -21.177 -1.433 Td (\215\030\036\r\036\027\021\017\r\027\026\016 \035\017\020\026\021\031\030\ \026 )Tj /T1_0 1 Tf (n)Tj /T1_1 1 Tf ( \(%\))Tj 21.177 0 Td (13)Tj /Span<>> BDC ( )Tj EMC (\(22,0%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.02 Tw 8.82 0 0 9 70.8661 510.2249 Tm (\020\004\206\f\t\204\004 4.)Tj 0 0 0 1 k /GS1 gs /T1_0 1 Tf ( \217\024\025\031\021\025\013\027 \200\020\032\020\n\023\027\032\022\024\ \023\022\n\022 \205\004\202 \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \206\210\207\002)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.027 Tw 9 0 0 9 70.8661 499.4248 Tm [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 4)-38(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0 Tw 3.337 0 Td [( M)0.8(a)-6.3(i)4(n s)0.5(o)-4(n)-2.4(o)-8.6(g)-1.5(r)3.3(a)-5.2(p)-1.1(h)1.7(i)-1.8(c c)-2.4(ha)-4.2(r)3.3(a)-9.2(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29(i)-1.8(c)-26.7(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(A)10(F o)-3.9(n TR)11.5(U)13.9(S)]TJ ET /GS2 gs q 1 0 0 1 70.8661 494.9229 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 454.9036 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 229.8563 494.9229 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 454.9036 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 292.2185 454.9036 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 454.6536 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 405.0424 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 229.8563 454.6536 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 405.0424 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 292.2185 405.0424 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 404.7924 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 355.1811 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 229.8563 404.7924 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 355.1811 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 292.2185 355.1811 cm 0 0 m 0 49.361 l S Q q 1 0 0 1 70.8661 354.9311 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 354.9311 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_2 1 Tf 8 0 0 8 130.3145 471.8883 Tm (\200\002\220\004\213\004\003\r\f\t)Tj 13.178 1.8 Td (\026\217\r \212\004\204\t\r\b\003\013, )Tj 0.384 -1.2 Td (\220\f\211\201\r\b\b\013\r )Tj -0.655 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r)Tj 2.046 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60)Tj /T1_1 1 Tf -21.998 -1.433 Td (\210\021\027\024\001\036\027\017\036 \f\r\017\013\036\r\024\020\024 \b\024\ \007\026 \022)Tj /Span<>> BDC ( )Tj EMC (\027\026\030\031\032\027\024\n\031 )Tj T* (\f\235\017\027\022\021\036\030\031)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj -0.01 Tc 1.063 -1.2 Td (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 \(\023\024\r\036\ \030\b\027\024\f\021\027\026\016 \023\024\030\006\017\016\))Tj 0 Tc T* (\221\030\026\027\f\f\235\017\027\022\021\036\030\027\t\005 \(\020\035\031\ \002\024\022\026\016 \023\024\030\006\017\016\))Tj T* (\233\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\005)Tj 20.364 2.4 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13,3%\))Tj -0.25 -1.2 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(18,3%\))Tj T* (41)Tj /Span<>> BDC ( )Tj EMC (\(68,3%\))Tj -21.177 -1.433 Td (\214\024\022\026\035\017\026\006\017\016 \r\027\031\021\030\036\027\027\ \036\020\024 \f\r\017\013\036\r\024\020\024 )Tj T* (\024\021\r\036\030\f\021\017\016)Tj /T1_0 1 Tf (, n)Tj /T1_1 1 Tf ( \(%\))Tj 1.063 -1.2 Td (\215\036\030\036\007\027\016\016)Tj T* (\207\024\022\024\r\026\016)Tj T* (\003\026\007\027\016\016)Tj 20.114 2.4 Td (36)Tj /Span<>> BDC ( )Tj EMC (\(60,0%\))Tj 0.25 -1.2 Td (6)Tj /Span<>> BDC ( )Tj EMC (\(10,0%\))Tj -0.25 -1.2 Td (18)Tj /Span<>> BDC ( )Tj EMC (\(30,0%\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.074 Tw 9 0 0 9 70.8661 338.2118 Tm [(\020\004\206\f\t\204\004 )0.6(5.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf [( )0.5(\225\020\032\020\n\023\027\032 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 10.123 0 Td [(\f\031\n\020\f\022\016\020\006\022\t )0.5(\b\025\031\235\025\013\200 )0.5(\016\020\023\027\n\031\021 )0.6(\(\033\031 )]TJ 0 Tw -10.123 -1.2 Td (\030\020\025\025\013\026 \206\210\207\002\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf -0.027 Tc 0.059 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 5)-24.2(.)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.032 Tw 3.355 0 Td [( L)-9.7(o)-12.5(c)3.2(a)-4.5(li)8(z)8.4(a)-9.2(t)-29.1(i)-1.4(o)-4(n a)-5.1(n)-4.8(d f)-13.4(e)-7.5(a)-9.2(t)-1.1(u)1.6(r)-2(e)-22(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-3(u)1.6(r)-9.1(u)-1.5(le)-7(n)-0.6(t e)-32.4(x)-32.5(t)-1.6(e)-7(n)3.7(s)-12.5(i)-1.4(o)-4(n)3.7(s \()61.4(a)-9.2(c)]TJ 0 Tw 20.915 0 Td (-)Tj 0.003 Tc -0.003 Tw -24.271 -1.2 Td [(c)5.8(ordi)6.9(n)2.4(g)3( to)]TJ /Span<>> BDC 3.956 0 Td ( )Tj EMC [(T)2.7(R)14.6(U)16.9(S)36.4(\))]TJ ET /GS2 gs q 1 0 0 1 70.8661 301.3098 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 261.2906 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 229.8563 301.3098 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 261.2906 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 292.2185 261.2906 cm 0 0 m 0 39.769 l S Q q 1 0 0 1 70.8661 261.0406 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 249.8293 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 261.0406 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 249.8293 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 249.8293 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 249.5793 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 238.368 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 249.5793 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 238.368 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 238.368 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 238.118 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 226.9067 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 238.118 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 226.9067 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 226.9067 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 226.6567 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 215.4455 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 226.6567 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 215.4455 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 215.4455 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 215.1955 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 203.9842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 215.1955 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 203.9842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 203.9842 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 203.7342 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 192.5229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 203.7342 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 192.5229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 192.5229 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 192.2729 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 181.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 192.2729 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 181.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 181.0616 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 180.8116 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 169.6003 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 180.8116 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 169.6003 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 169.6003 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 169.3503 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 71.1161 158.139 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 229.8563 169.3503 cm 0 0 m 62.612 0 l S Q q 1 0 0 1 229.8563 158.139 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 292.2185 158.139 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 70.8661 157.889 cm 0 0 m 158.99 0 l S Q q 1 0 0 1 229.8563 157.889 cm 0 0 m 62.612 0 l S Q BT /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 8 0 0 8 77.7353 278.2752 Tm (\225\004\006\004\220\003\r\006 \t)Tj /Span<>> BDC ( )Tj EMC (\f\002\220\004\f\t\213\004\204\t\235 \n\b\002\005\b\013\216 \213\004\003\ \r\220\002)Tj 19.75 1.8 Td (\026\217\r \212\004\204\t\r\b\003\013, )Tj 0.384 -1.2 Td (\220\f\211\201\r\b\b\013\r )Tj -0.655 -1.2 Td ()Tj /Span<>> BDC ( )Tj EMC (\t\217\217\f\r\240\002\004\b\t\r)Tj 0.546 -1.2 Td (N)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (60, )Tj /T1_3 1 Tf (n)Tj /T1_2 1 Tf ( \(%\))Tj /T1_1 1 Tf -20.497 -1.433 Td (\204\027\024\032\036\f\021\r\036\027\027\t\036 \026\021\036\022\017 \(>\ )Tj /Span<>> BDC ( )Tj EMC (1\))Tj 21.557 0 Td (23)Tj /Span<>> BDC ( )Tj EMC (\(38,3\))Tj -21.557 -1.433 Td (\215\024\007\022\024\032\027\t\005 \026\021\036\022)Tj 21.557 0 Td (16)Tj /Span<>> BDC ( )Tj EMC (\(26,7\))Tj -21.557 -1.433 Td (\230\001\017\024\026\027\026\035\034\027\t\005 \026\021\036\022)Tj 21.557 0 Td (21)Tj /Span<>> BDC ( )Tj EMC (\(35,0\))Tj -21.557 -1.433 Td (\217\036\021\030\024\030\036\022\021\026\035\034\027\t\005 \026\021\036\ \022)Tj 21.557 0 Td (11)Tj /Span<>> BDC ( )Tj EMC (\(18,3\))Tj -21.557 -1.433 Td (\215\036\035\034\r\017\024\030\036\022\021\026\035\034\027\t\005 \026\021\ \036\022)Tj 21.807 0 Td (9)Tj /Span<>> BDC ( )Tj EMC (\(15,0\))Tj -21.807 -1.433 Td (\204\036\032\f\235\017\027\022\021\036\030\027\t\005 \026\021\036\022)Tj 21.807 0 Td (8)Tj /Span<>> BDC ( )Tj EMC (\(13,3\))Tj -21.807 -1.433 Td (\215\024\007\f\035\017\017\f\021\t\005 \026\021\036\022)Tj 21.807 0 Td (2)Tj /Span<>> BDC ( )Tj EMC (\(3,33\))Tj -21.807 -1.433 Td (\003\026\021\036\022 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\022\021\024\r\026\020\017\027\026\035\034\027\024\005 \023\036\030\ \036\020\024\030\024\007\022\036)Tj 22.057 0 Td (5)Tj /Span<>> BDC ( )Tj EMC (\(8,3\))Tj -22.057 -1.433 Td (\200\027\031\021\030\017\f\021\036\027\024\004\027\t\005 \026\021\036\022\ )Tj 22.057 0 Td (3)Tj /Span<>> BDC ( )Tj EMC (\(5,0\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.2525 56.0378 Tm (74)Tj ET endstream endobj 1252 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.251 Tw 10 0 0 10 42.5197 456.9139 Tm [(\f\r\017\013\036\r\024\020\024 )0.6(\024\021\r\036\030\f\021\017\016 )0.5(\030\026\035\017\004\027\t\n\017 )0.6(\n\036\021\024\007\026\n\017, )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 20.659 0 Td (\021\024\n )Tj 0 Tw -20.659 -1.218 Td (\004\017\f\035\036 \017)Tj /Span<>> BDC ( )Tj EMC (\253\021\030\026\007\017\006\017\024\027\027\t\n\017\273.)Tj 0.071 Tw 0 -1.218 TD (\233\235\235\036\022\021\017\r\027\024\f\021\034 \253\021\030\026\007\017\ \006\017\024\027\027\t\b\273 \n\036\021\024\007\024\r, \027\036\f\024\n\027\ \036\027)Tj 0 Tw (-)Tj T* (\027\024, \r\t\001\036 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.23 Tw T* (\210\007\027\026\022\024 \030\017\f\022 \023\024\r\030\036\032\007\036\027\ \017\016 \026\023\017\030\026\021\036\035\034\027\024\020\024 \026\023\023\ \026\030\026\021 )Tj 0.111 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\017 \007\026\027\027\t\b \f\023\ \024\f\024\002\024\r )Tj 0.012 Tw T* (\007\024\f\021\017\020\026\036\021 26%. \222\035\036\007\031\036\021 \024\ \021\n\036\021\017\021\034, \004\021\024 \020\027\024\005\027\t\036 \026\ \021\036\022\017 )Tj 0.221 Tw T* (\021\026\022\032\036 \n\024\020\031\021 \016\r\035\016\021\034\f\016 \024\ \021\027\024\f\017\021\036\035\034\027\t\n \023\030\036\023\016\021\f\021\ \r\017\036\n )Tj 0.233 Tw T* (\007\035\016 \023\030\017\n\036\027\036\027\017\016 \253\021\030\026\007\ \017\006\017\024\027\027\t\b\273 \n\036\021\024\007\024\r, \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 )Tj 0.149 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC 0.818 0 Td [(\004\036\n )0.6(\017\b )0.6(\007\030\036\027\017\030\024\r\026\027\017\036 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 10.398 0 Td [(\022\026\004\036\f\021\r\036 )0.6(1 )0.6(\220\021\026\023\026 )0.6(\035\036\004\036\027\017\016 )]TJ 0 Tw -11.216 -1.218 Td (\023\030\024\r\024\007\017\021\f\016 \031)Tj /Span<>> BDC ( )Tj EMC (48\22665% \023\026\006\017\036\027\021\024\r.)Tj 0.113 Tw T* (\200 2022 \020\024\007\031 \r)Tj /Span<>> BDC ( )Tj EMC (\205\206\207\211 \253\203\204\230\037 \022\024\035\024\023\030\024\022\021\ \024\035\024\020\017\017 \017\n\036\027\017 )Tj 0.208 Tw T* (\202.\203.)Tj /Span<>> BDC ( )Tj EMC (\217\t\032\017\b\273 \204\017\027\007\030\026\r\026 \217\024\f\f\017\017\ \030\026\030\026\002\024\021\026\027 \017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036)Tj 0 Tw (-)Tj 0.014 Tw T* (\007\030\036\027 \f\023\024\f\024\002 \b\017\030\031\030\020\017\004\036\ \f\022\024\005 \035\017\022\r\017\007\026\006\017\017 \f\r\017\013\036\005\ \023\030\016)Tj 0 Tw (-)Tj 0.05 Tw T* (\n\024\005 \022\017\001\022\017 \n\036\021\024\007\024\n \023\036\030\036\ \n\036\013\036\027\017\016 \035\026\021\036\030\026\035\034\027\024\020\024\ \023\030\016)Tj 0 Tw (-)Tj T* (\n\024\022\017\001\036\004\027\024\020\024 \035\024\f\022\031\021\026 [2\ 4].)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 237.7099 Tm (\017\034\r\237)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.195 Tw 10 0 0 10 42.5197 213.3539 Tm (\210\006\036\027\017\021\034 \220\235\235\036\022\021\017\r\027\024\f\021\ \034 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\034 \b\017\030\031\030\020\017\004\ \036)Tj 0 Tw (-)Tj 0.091 Tw T* (\f\022\024\020\024 \n\036\021\024\007\026 \035\017\022\r\017\007\026\006\ \017\017 \f\r\017\013\036\005 \023\030\016\n\024\005 \022\017\001\022\017\ \035\026)Tj 0 Tw (-)Tj 0.044 Tw T* [(\021\036\030\026\035\034\027\t\n )0.6(\023\030\016\n\024\022\017\001\036\004\027\t\n )0.6(\035\024\f\022\031\021\024\n )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 16.575 0 Td [(\023\026\006\017\036\027\021\024\r )0.6(\f\024 )]TJ 0 Tw -16.575 -1.218 Td (\253\f\035\024\032\027\t\n\017\273 \f\r\017\013\026\n\017 \023\030\016\n\ \024\005 \022\017\001\022\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 140.2859 Tm [(\f\026\017\031\034\022\024\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.225 Tw 10 0 0 10 42.5197 115.9299 Tm (\212\035\016 \024\006\036\027\022\017 \220\235\235\036\022\021\017\r\027\ \024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC (\002\036\024\023\026\f\027\024\f\021\017 \f\023\024\f\024)Tj 0 Tw (-)Tj 0.354 Tw T* (\002\026 \b\017\030\031\030\020\017\004\036\f\022\024\005 \035\017\022\r\ \017\007\026\006\017\017 \253\f\035\024\032\027\t\b\273 \f\r\017\013\036\ \005 )Tj 0.209 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017 \n\036\021\024\007\024\n \023\ \036\030\036\n\036\013\036\027\017\016 \035\026\021\036\030\026\035\034\027\ \024\020\024 )Tj 0.169 Tw T* [(\023\030\016\n\024\022\017\001\036\004\027\024\020\024 )0.6(\035\024\f\022\031\021\026 )0.6(\023\030\024\r\036\007\036\027\024 )0.5(\024\007\027\024\006\036\027\021\030\024\r\024\036 )]TJ 0.02 Tw 23.244 37.752 Td (\024\007\027\024\020\030\031\023\023\024\r\024\036 \023\030\024\f\023\036\ \022\021\017\r\027\024\036 \017\f\f\035\036\007\024\r\026\027\017\036, \r\ )Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024)Tj 0 Tw (-)Tj 0.149 Tw T* [(\030\024\036 \r\022\035\033\004\036\027\t )0.5(60 \023\026\006\017\036\027\021\024\r )0.5(\f\024 \f\035\024\032\027\t\n\017 )0.5(\f\r\017\013\026\n\017 )]TJ 0.241 Tw T* (\023\030\016\n\024\005 \022\017\001\022\017, \024\023\036\030\017\030\024\ \r\026\027\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\024\007 \f)Tj /Span<>> BDC ( )Tj EMC (\027\024\016\002\030\016 )Tj 0 Tw T* (2022 \023\024)Tj /Span<>> BDC ( )Tj EMC (\016\027\r\026\030\034 2025 \020\020.)Tj 0.144 Tw T* (\200 \020\030\031\023\023\036 \017\f\f\035\036\007\024\r\026\027\017\016\ \027\036\027\026\004\017\021\036\035\034\027\024 \023\030\036\024\002\035\ \026\007\026\035\017 )Tj 0.2 Tw T* (\032\036\027\013\017\027\t)Tj /Span<>> BDC ( )Tj EMC (\227 32)Tj /Span<>> BDC ( )Tj EMC (\(53,3%\), \n\031\032\004\017\027 \002\t\035\024 28)Tj /Span<>> BDC ( )Tj EMC (\(46,7%\). )Tj -0.012 Tw T* (\200\024\030\026\f\021 \r\026\030\034\017\030\024\r\026\035 \024\021 32\ \007\024)Tj /Span<>> BDC ( )Tj EMC (66 \035\036\021 \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (46,5 )Tj 0.003 Tw T* (\(39,0; 55,5\) \035\036\021, \026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\007\024\035\032\017\021\036\035\034\027\024\f\021\034 \026\027\ \026\n\027\036\026 \026\002\024)Tj 0 Tw (-)Tj 0.052 Tw T* (\035\036\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \024\021 1 \007\024)Tj /Span<>> BDC ( )Tj EMC (112 \n\036\f\016\006\036\r \f)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\026\027\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (7 \(4,0; )Tj 0.165 Tw T* (13,0\). \212\030\036\027\017\030\031\033\013\017\036 \024\023\036\030\026\ \006\017\017 \(\035\017\020\026\021\031\030\026\) \002\t\035\017 \r\t)Tj 0 Tw (-)Tj T* (\023\024\035\027\036\027\t \031)Tj /Span<>> BDC ( )Tj EMC (13/60 \(22,0%\) \023\026\006\017\036\027\021\024\r \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (3\).)Tj /T1_3 1 Tf 0 -2.436 TD (\215\027\023\031\030\013 \031\240\024\f\027\030\031\021\020\025\022\t \033\ \020\006\022\027\025\023\031\021)Tj /T1_1 1 Tf 0.148 Tw 0 -1.218 TD (\200 \030\026\n\022\026\b \017\f\f\035\036\007\024\r\026\027\017\016 \r\f\ \036\n \023\026\006\017\036\027\021\026\n \007\024)Tj /Span<>> BDC ( )Tj EMC (\017)Tj /Span<>> BDC ( )Tj EMC (\023\024\f\035\036 )Tj 0.16 Tw T* (\(\r)Tj /Span<>> BDC ( )Tj EMC (\f\030\024\022\017 \024\021 3 \007\024)Tj /Span<>> BDC ( )Tj EMC (6 \n\036\f\016\006\036\r\) \024\023\036\030\026\021\017\r\027\024\020\024\ \035\036\004\036\027\017\016 )Tj 0.089 Tw T* [(\f\r\017\013\026 \023\030\016\n\024 \022\017\001\022\017 \n\036\021\024\007\ \024\n )0.5(\214\215\214 )0.5(\r\t\023\024\035\027\016\035\017 )0.5(\021\030\026\027\f)]TJ 0 Tw (-)Tj 0.222 Tw T* (\030\036\022\021\026\035\034\027\024\036 \031\035\034\021\030\026\r\031\ \022\024\r\024\036 \017\f\f\035\036\007\024\r\026\027\017\036 \017)Tj /Span<>> BDC ( )Tj EMC (\024\006\036\027\022\031 )Tj 0.402 Tw T* [(\235\031\027\022\006\017\017 \026\023\017\030\026\021\036\035\034\027\024\ \020\024 )0.5(\026\023\023\026\030\026\021\026 \023\030\016\n\024\005 \022\017\001\022\ \017 )]TJ -0.009 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\235\017\027\022\021\036\030\024\n\036\021\030\ \017\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\001\022\026\035\t W)22(e)-18(xner. \200)]TJ /Span<>> BDC ( )Tj EMC (\030\026\n)Tj 0 Tw (-)Tj -0.024 Tw T* (\022\026\b \023\030\024\021\024\022\024\035\026 \027\026\002\035\033\007\ \036\027\017\016 \023\026\006\017\036\027\021\t \023\024\f\035\036 \024\023\ \036\030\026\006\017\017 )Tj 0.374 Tw T* [(\036\032\036\007\027\036\r\027\024 \023\030\024\b\024\007\017\035\017 )0.5(\024\006\036\027\022\031 \002\024\035\036\r\024\020\024 \f\017\027\007\030\ \024\n\026 )]TJ 0 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\r\017\031\026\035\034\027\024-\026\027\026\035\024\020\024\r\024\005 \001\ \022\026\035\036 \(\200\202\231\).)Tj /T1_3 1 Tf 1.74 Tw 0 -2.436 TD (\220\020\025\025\013\027 \023\032\020\025\024\032\027\n\023\020\f\017\025\ \031\b\031 \r\f\017\023\032\020\016\021\r\n\031\021\031\b\031 )Tj 0 Tw 0 -1.218 TD (\022\024\024\f\027\030\031\021\020\025\022\t)Tj /T1_1 1 Tf 0.159 Tw T* (\215\024 \007\026\027\027\t\n \031\035\034\021\030\026\r\031\022\024\r\024\ \020\024 \017\f\f\035\036\007\024\r\026\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 )Tj 0.197 Tw T* [(\023\030\036\024\002\035\026\007\026\035\017 \023\026\006\017\036\027\021\ \t )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\220\022\f\021\030\026\f\235\017\027\022\021\036\030\027\t\n\017 )0.5(\f\r\017)]TJ 0 Tw (-)Tj -0.04 Tw T* (\013\026\n\017 \(41)Tj /Span<>> BDC ( )Tj EMC (\(68,3%\)\). \221\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\002\024\035\034\001\017\027\f\021\r\036 \027\026\002\035\033\007\036\027\ \017\005 )Tj 0.313 Tw T* (\026\235\017\022\f\017\030\024\r\026\027\t \020\027\024\005\027\t\036 \ \026\021\036\022\017 \r)Tj /Span<>> BDC ( )Tj EMC (\023\026\030\026\030\036\022\021\026\035\034\027\t\b )Tj 0.203 Tw T* (\022\035\036\021\004\026\021\024\004\027\t\b \023\030\024\f\021\030\026\027\ \f\021\r\026\b \017/\017\035\017 \022\017\001\036\004\027\024\005 \f\021\ \036\027)Tj 0 Tw (-)Tj 0.028 Tw T* (\022\036 \(39/60 \(65,0%\)\). \215\030\017\004\036\n \031)Tj /Span<>> BDC ( )Tj EMC (23/39 \(38,3%\) \002\024\035\034\027\t\b )Tj 0 Tw T* (\017\n\036\035\017\f\034 \n\027\024\032\036\f\021\r\036\027\027\t\036 \026\ \021\036\022\017 \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (4,5\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\203\203\027\n\023\022\021\025\031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\240\027\016\031\033\020\024\025\031\024\023\017 \253\024\203\022\025\n\023\ \027\032\031\024\240\027\032\027\b\020\005\212\022\200\273 \026\027\023\031\ \030\031\021 \f\027\007\027\025\022\t \024\021\022\212\027\235 \033\032\t\ \026\031\235 \n\022\213\n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( E)25.6(f)-42.4(f)-13.4(e)-10.9(c)-32.3(t)-29.1(i)-2.9(v)2.3(e)-7(n)-2.4(e)-22(s)-10.5(s a)-5.1(n)-4.8(d s)3.5(a)-0.6(f)-13.4(e)-8.6(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(s)4.4(p)-1.1(h)1.7(i)3.9(n)-2.9(c)-32.4(t)-1.6(e)-6(r)22.3(-)-1.5(s)4.4(p)-6.3(a)-4.1(r)-39(i)3.9(n)-0.6(g t)-1.6(e)-10.9(c)-2.5(h)0.8(n)1.7(iq)-3(u)-3.2(e)-21.9(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)-2(e)-7.4(a)-9.2(t)-10.6(m)-5.3(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5.1(na)-4.5(l \243)6.4(s)-14.8(t)-1.1(u)-1.6(l)-1(a)-7.2(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 178.8327 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 258.2028 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 337.5728 715.181 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 416.9429 715.181 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 684.7618 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 684.5118 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 684.5118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 684.5118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 684.5118 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 684.5118 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 673.3005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 673.0505 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 673.0505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 673.0505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 673.0505 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 673.0505 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 661.8392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 661.5892 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 661.5892 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 661.5892 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 661.5892 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 661.5892 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 650.3779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 650.1279 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 650.1279 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 650.1279 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 650.1279 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 650.1279 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 638.9166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 638.6666 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 638.6666 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 638.6666 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 638.6666 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 638.6666 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 627.4553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 627.2053 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 627.2053 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 627.2053 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 627.2053 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 627.2053 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 615.994 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 615.744 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 615.744 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 615.744 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 615.744 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 615.744 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 604.5328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 604.2828 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 178.8327 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 604.2828 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 416.9429 604.2828 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 100.1613 696.9464 Tm (\215\r\003\002\240)Tj 11.383 0.6 Td (\231\226\226\r\220\003\t\b\002\217\003\001)Tj 0.414 -1.2 Td (\(Min\232Max, %\))Tj 8.485 1.8 Td (\200\002\217\f\r\002\212\r\006\004\204\t\002\b\b\004\235 )Tj 3.575 -1.2 Td (\025\032\255)Tj -2.139 -1.2 Td (\(Min\232Max, %\))Tj 9.436 1.8 Td (\027\b\002\005\b\013\r \213\004\003\r\220\t)Tj 0.486 -1.2 Td (\(Min\232Max, %\))Tj 9.804 1.8 Td (\200\006\r\r\b\003\t\b\004\235 )Tj 1.179 -1.2 Td (\f\t\n\004\003\210\006\004)Tj -1.061 -1.2 Td (\(Min\232Max, %\))Tj /T1_1 1 Tf -48.381 -1.433 Td (LIFT [1,2,3])Tj 20.336 0 Td (28\22694)Tj 10.171 0 Td (1\22623)Tj 10.699 0 Td (6)Tj 9.671 0 Td (43)Tj -50.878 -1.433 Td (VAAFT [4,5])Tj 20.336 0 Td (22\22687)Tj 10.523 0 Td (0-1)Tj 10.347 0 Td (2)Tj 9.671 0 Td (39)Tj -50.878 -1.433 Td (\205\017\002\030\017\027\024\r\t\005 \022\035\036\005 [6,7])Tj 20.336 0 Td (42\22679)Tj 10.949 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (68)Tj -50.878 -1.433 Td (\204\222\025 [8,9])Tj 20.086 0 Td (27\226100)Tj 11.199 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (59)Tj -50.878 -1.433 Td (\025\024\035\035\026\020\036\027\024\r\t\005 \017\n\023\035\026\027\021 \ [10,11])Tj 20.336 0 Td (20\22688)Tj 10.949 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (73)Tj -50.878 -1.433 Td (OTSC [12,13])Tj 20.336 0 Td (38\22665)Tj 10.949 0 Td (0)Tj 9.921 0 Td (0)Tj 9.671 0 Td (98)Tj -50.878 -1.433 Td (FiLaC [14,15])Tj 20.336 0 Td (30\22682)Tj 10.171 0 Td (0\22610)Tj 10.699 0 Td (0)Tj 9.671 0 Td (81)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 9 0 0 9 42.5197 587.5635 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \230\203\203\027\n\023\022\021\025\031\024\023\017 \022)Tj /Span<>> BDC ( )Tj EMC (\240\027\016\031\033\020\024\025\031\024\023\017 \253\023\032\020\030\022\ \006\022\031\025\025\013\200\273 \026\027\023\031\030\031\021 \f\027\007\ \027\025\022\t \024\021\022\212\027\235 \033\032\t\026\031\235 \n\022\213\ \n\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf -0.027 Tc 0.027 Tw T* [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.334 0 Td [( E)25.6(f)-42.4(f)-13.4(e)-10.9(c)-32.3(t)-29.1(i)-2.9(v)2.3(e)-7(n)-2.4(e)-22(s)-10.5(s a)-5.1(n)-4.8(d s)3.5(a)-0.6(f)-13.4(e)-8.6(t)-33.8(y o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)3.3(a)-8.7(d)-3(i)-3.4(t)-29.1(i)-1.4(o)-3.9(na)-4.5(l m)-5.3(e)-8.6(t)-10.6(h)-2.4(o)-12(d)-5.7(s i)3.9(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(t)-9.6(r)-2(e)-7.5(a)-9.1(t)-10.6(m)-5.3(e)-7(n)-0.6(t o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-5.1(na)-4.5(l \243)6.4(s)-14.8(t)-1.1(u)-1.6(l)-1.1(a)-7.1(s)]TJ ET /GS2 gs q 1 0 0 1 42.5197 572.2615 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 178.8327 572.2615 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 258.2028 572.2615 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 337.5728 572.2615 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 416.9429 572.2615 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 496.313 541.8423 cm 0 0 m 0 30.169 l S Q q 1 0 0 1 42.5197 541.5923 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 178.8327 541.5923 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 258.2028 541.5923 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 541.5923 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 416.9429 541.5923 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 530.381 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 530.131 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 178.8327 530.131 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 258.2028 530.131 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 530.131 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 416.9429 530.131 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 509.3198 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 509.0698 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 42.7697 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 178.8327 509.0698 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 178.8327 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 258.2028 509.0698 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 337.5728 509.0698 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 416.9429 509.0698 cm 0 0 m 79.62 0 l S Q q 1 0 0 1 416.9429 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 488.2585 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 488.0085 cm 0 0 m 136.313 0 l S Q q 1 0 0 1 178.8327 488.0085 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 258.2028 488.0085 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 337.5728 488.0085 cm 0 0 m 79.37 0 l S Q q 1 0 0 1 416.9429 488.0085 cm 0 0 m 79.62 0 l S Q BT /GS1 gs /T1_4 1 Tf 8 0 0 8 100.1613 554.027 Tm (\215\r\003\002\240)Tj 11.383 0.6 Td (\231\226\226\r\220\003\t\b\002\217\003\001)Tj 0.414 -1.2 Td (\(Min\232Max, %\))Tj -0.233 Tw 8.485 1.8 Td (\200\002\217\f\r)Tj /Span<>> BDC ( )Tj EMC (\002\212\r\006\004\204\t\002\b\b\004\235 )Tj 0 Tw 3.575 -1.2 Td (\025\032\255)Tj -2.139 -1.2 Td (\(Min\232Max, %\))Tj 9.436 1.8 Td (\027\b\002\005\b\013\r \213\004\003\r\220\t)Tj 0.486 -1.2 Td (\(Min\232Max, %\))Tj 9.804 1.8 Td (\200\006\r\r\b\003\t\b\004\235 )Tj 1.179 -1.2 Td (\f\t\n\004\003\210\006\004)Tj -1.061 -1.2 Td (\(Min\232Max, %\))Tj /T1_1 1 Tf -48.381 -1.433 Td (\253\217\036\032\031\013\026\016\273 \035\017\020\026\021\031\030\026 [1\ 6,17])Tj 20.336 0 Td (70\22693)Tj 10.171 0 Td (8\22622)Tj 10.699 0 Td (0)Tj 9.921 0 Td (0)Tj -51.128 -1.433 Td (\230\f\f\036\004\036\027\017\036 \f\r\017\013\026 \f)Tj /Span<>> BDC ( )Tj EMC (\031\001\017\r\026\027\017\036\n )Tj T* (\f\235\017\027\022\021\036\030\026 [18\22621])Tj 20.336 1.2 Td (84\22696)Tj 10.171 0 Td (7\22627)Tj 10.671 0 Td (\226)Tj 9.699 0 Td (48)Tj -50.878 -2.633 Td (\215\030\016\n\024\022\017\001\036\004\027\t\005 \(\023\030\024\022\f\017\ \n\026\035\034\027\t\005\) )Tj T* (\035\024\f\022\031\021 [22,23])Tj 20.336 1.2 Td (55\22699)Tj 10.171 0 Td (0\22625)Tj 10.449 0 Td (35)Tj 9.921 0 Td (65)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8768 56.0378 Tm (73)Tj ET endstream endobj 1251 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 337.5706 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 337.5706 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 300.3627 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 300.3627 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 246.2935 cm 0 0 m 453.543 0 l S Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 18 0 0 18 141.2594 723.8861 Tm [(Displaced later)21(al r)31(ectal flap for anal f)-21(istulas)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 70.8661 699.3822 Tm [(Timur\022)-23.2(V)62(.\022)-23.3(Nikishin)]TJ 8.162 0 0 8.162 164.0419 704.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 168.6778 699.3822 Tm [(, Iv)10(an\022)-23.3(V)62.1(.\022)-23.3(K)40.9(ostar)31.1(e)11(v)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 266.9692 704.0442 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 278.2899 699.3822 Tm [(, Ale)21(x)11(ander\022)-23.2(Y)40(u.\022)-23.3(Titov)]TJ 0 Tw 8.162 0 0 8.162 395.5783 704.0442 Tm (1)Tj 14 0 0 14 400.2143 699.3822 Tm (, )Tj -23.525 -1.143 Td [(Maria\022)-23.2(A)-31(.\022)-23.3(Ignatenk)11(o)]TJ 8.162 0 0 8.162 181.3885 688.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 186.0245 683.3822 Tm [(, Ev)10(geny\022)-23.2(E.\022)-23.3(Zhark)11(ov)]TJ 0 Tw 8.162 0 0 8.162 298.9875 688.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 303.6234 683.3822 Tm [(, Ikr)20(omzh)11(on\022)-23.2(I.\022)-23.3(Dadash)11(e)11(v)]TJ 0 Tw 8.162 0 0 8.162 440.9465 688.0442 Tm (2)Tj 14 0 0 14 445.5825 683.3822 Tm (, )Tj -26.765 -1.143 Td [(Oleg\022)-23.3(M.\022)-23.2(Bir)-31(y)10(uk)11(ov)]TJ 8.162 0 0 8.162 170.4967 672.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 175.1327 667.3822 Tm [(, Anastasia\022)-23.2(E.\022)-23.3(P)10(er)20(shina)]TJ 0 Tw 8.162 0 0 8.162 302.5706 672.0442 Tm (1)Tj 0.023 Tw 14 0 0 14 307.2065 667.3822 Tm [(, Andr)31(ey\022)-23.2(A)-31(.\022)-23.3(Mudr)20(ov)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 420.8833 672.0442 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 70.8661 653.043 Tm (1)Tj 0.023 Tw 10 0 0 10 74.1775 649.713 Tm [(R)20(y)21(zhikh National Medical Resear)31(ch Center of\022)-23.3(Colopr)20.1(octology \(Saly)21(ama Adily)21(a\022)-23.3(st., 2, Moscow)22(, 1)125(23)58(423, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 70.8661 641.043 Tm (2)Tj 0.023 Tw 10 0 0 10 74.1775 637.713 Tm [(Russian Medical Academ)21.1(y of\022)-23.3(Continuous Pr)20(ofessional Education \(Barrikadnay)21.1(a\022)-23.3(st., 2/1)69(, bld. 1)69(, Moscow)22(, )]TJ -0.331 -1.2 Td [(1)125(2)23(5)23(99)35(3, Russia\))]TJ /T1_1 1 Tf 0.042 Tw 9 0 0 9 119.0551 607.209 Tm [(AIM: ev)16(aluating ef)-39.9(fectiv)13(eness and safety of the method of f)-43(istula repair using a lateral rectal f)-22(lap in patients with )]TJ 0.023 Tw 0 -1.111 TD [(anal f)-43(istulas in)11(v)13(olving more than 1/3 of the e)-15(xter)-13.9(nal sphincter \(com)16(ple)-15(x anal f)-43(istulas\).)]TJ 0.012 Tc 0.111 Tw T* [(P)45(A)45(TIENT)-10(S A)53(ND METHODS: a sing)13(le-centre, p)46(rospectiv)13(e, sing)13(le-g)14(roup study included 60 patients who under)-32(w)12(ent)12.1( )]TJ 0.065 Tw T* [(anal f)-43(istula repair using a lateral rectal f)-22(lap \(LRF\). The check)32(-up before and af)-46(ter the surg)12(er)-43(y w)12.9(as car)-16(r)-37(ied out)12( )]TJ -0.014 Tw T* (using instrumental methods)Tj /Span<>> BDC ( )Tj EMC [(\227 transrectal ultrasound \(TR)27(US\) and sphincterometr)-43(y)32(. The ma)10(jor)-37(ity of patients had)12( )]TJ -0.001 Tw 0 -1.111 TD [(an e)-15(xtrasphincter)-37(ic f)-43(istula \(41/60 \(68.3%\)\), pararectal cavities w)12(ere detected in 39/60 \(65%\) patients, includ)]TJ 0 Tc 0 Tw (-)Tj 0.012 Tc 0.03 Tw 0 -1.111 TD [(ing multiple cavities in 23/39 \(38.3%\). The late results w)12(ere studied af)-46(ter 3\23112)]TJ /Span<>> BDC ( )Tj EMC [(months. The median follow-up)12( )]TJ 0.14 Tw T* [(w)13(as 7 \(4; 8\) months. The p)46(r)-37(imar)-43(y endpoint w)13(as the rate of non-recur)-16(rence cases \(treatment ef)-40(fectiv)13(eness\),)12( )]TJ 0.125 Tw T* [(the second)26(ar)-43(y ones w)12(ere the assess)33(ment of continence, pain syndrome, r)-37(isk factors for unsatisfactor)-43(y results)12( )]TJ -0.012 Tw T* [(\(recur)-16(rence\).)]TJ 0.008 Tc 0.035 Tw T* [(RESUL)30(T)-10(S: )0.6(the )0.6(ef)-40(fectiv)13(eness )0.6(of )0.5(the )0.6(LRF )0.6(method )0.6(w)13(as )0.5(48/60 )0.6(\(80%; )0.6(95% )0.5(CI )0.6(67.7; )0.5(89.2\) )0.6(cases. )0.6(Sphincterometr)-43(y )0.5(and)8( )]TJ 0.073 Tw T* [(W)30(e)-15(xner\222)37(s )0.5(incontinence )0.6(scale )0.5(show)12(ed )0.5(no )0.5(w)12(orsening )0.5(of )0.5(continence )0.5(af)-46(ter )0.6(surgical )0.5(treatment )0.6(\(1 )0.5(\(0; )0.5(3\) )0.6(point )0.6(before)8( )]TJ 0.053 Tw T* [(the surg)12(er)-42.9(y and 2 \(0; 3\) points af)-46(ter 3\2316)]TJ /Span<>> BDC ( )Tj EMC (months \(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.68\)\). The assess)33(ment of r)-36.9(isk factors for unsatisfactor)-43(y)8( )]TJ -0.024 Tw T* [(results )0.5(of )0.5(LRF )0.5(application )0.5(rev)13(ealed )0.5(such )0.5(factors )0.5(as )0.5(e)-15(xcess )0.5(body )0.5(w)12(eight )0.5(\(body )0.5(mass )0.5(inde)-15(x)]TJ /Span<>> BDC ( )Tj EMC 34.642 0 Td (\241)Tj /Span<>> BDC ( )Tj EMC 0.725 0 Td [(30.7 )0.5(k)15(g/m\262\) )0.5(\(body )0.5(mass)8( )]TJ 0.096 Tw -35.366 -1.111 Td [(inde)-15(x)]TJ /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC [(30.7 k)15(g/m\262\) \(odds ratio \(OR\))]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(1.14 \(95% coincidence inter)-42(v)16(al \(CI\) 1.02; 1.29\), p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.02\); purulent)8( )]TJ 0.057 Tw T* [(intersphincter)-37(ic leak)-23(s \(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5.50 \(95% CI 1.14; 26.6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.03\); purulent ischioanal leak)-23(s\(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(16.8 \(95% CI)8( )]TJ 0.051 Tw T* (3.20; 7.55\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.0009\) and purulent pelviorectal leak)-22.9(s\(OR)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7.86 \(95% CI 1.69; 36.6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.008\), as w)12(ell as)7.9( )]TJ 0.067 Tw 0 -1.111 TD (multiple purulent cavities \(OR)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (4.40 \(95% CI 1.14; 16.9\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.03\).A)14(t the same time, the LRF method allows)8( )]TJ 0.104 Tw 0 -1.111 TD [(to achiev)13(e recov)13(er)-43(y in 28/39 \(71.8%\) patients with solitar)-43(y cavities, and in 15/23 \(65.2%\) cases of multiple)8( )]TJ -0.008 Tw T* (cavities.)Tj 0 Tc 0 Tw T* [(C)21(ON)22(CLUSION: the LRF method allows for the one-stag)12.1(e elimination of \244com)16(ple)-15(x\245 anal f)-43(istulas in 80% of cases, with)]TJ (-)Tj -0.005 Tw T* [(out w)12(orsening of anal continence. According to the Visual Analogue Scale, the\ median score did no)13(t e)-15(xceed 3 for the )]TJ -0.007 Tw T* [(entire follow-up per)-37(iod, what cor)-15.9(responds to a low lev)13(el of pain; at the same time, the maximum intensity w)13(as no)13(ted )]TJ 0.023 Tw T* (on the 2\2314)Tj /Span<>> BDC ( )Tj EMC [(d)25.9(ays af)-46(ter surg)12(er)-43(y)42(, whereas by the 10 d)26(ay almost all patients did no)13(t e)-15(xper)-37(ience pain.)]TJ /T1_2 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 361.9398 Tm [(KEYW)22(ORDS:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( anal f)-43(istula, RF)105(, lateral rectal f)-22(lap, LRF)105(, anal incontinence, AI)]TJ /T1_2 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_2 1 Tf 0.013 Tc -0.046 Tw -9.871 -2.617 Td [(F)3.5(O)-4.4(R)9( C)-17.2(I)-15.3(T)45.6(A)37.8(T)-24.2(I)-1.1(ON:)]TJ /T1_3 1 Tf -0.001 Tc -0.037 Tw 6.083 0 Td [( N)-13.2(i)-6.4(k)-40.8(i)-7.2(s)-8.5(h)-13.7(i)-3(n)]TJ /Span<>> BDC ( )Tj EMC [(T)52.7(.)40.9(V)39.9(.)-23.2(, K)-10.9(o)-15.6(s)-29(t)-36.6(a)-9.9(r)-18.8(e)-15.6(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.1(.)40.9(V)39.9(.)-23.2(, T)-17(i)-15.5(t)-21.7(o)-10(v A)-22.7(.)51.9(Y)12.8(u)-8.7(.)-23.3(, I)-4.5(g)-8.5(n)-7.5(a)-18(t)-24.4(e)-11.3(n)-8.5(k)-3.5(o)]TJ /Span<>> BDC ( )Tj EMC [(M)-6.9(.)-23.6(A)-22.7(.)-23.3(, Z)-19.4(h)-8(a)-10(r)-30.5(k)-3.5(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(E)-5.4(.)0.7(E)-5.3(.)-23.3(, D)-11.5(a)-12.8(d)-9(a)-26.3(s)-8.6(h)-14.8(e)-15.6(v)]TJ /Span<>> BDC ( )Tj EMC [(I)-10.1(.)-9.5(I)-10(.)-23.3(, B)-14.7(i)-5.7(r)-60.3(y)-21.3(u)-9.3(k)-3.5(o)-10(v)]TJ /Span<>> BDC ( )Tj EMC [(O)11.7(.)-7(M)-6.9(.)-23.2(, P)-3.9(e)-11.9(r)-30(s)-8.5(h)-13.8(i)-2.9(n)-7.6(a)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.8(.)0.7(E)-5.3(.)-23.3(, M)-5.5(u)-10.1(d)-10.2(r)-15.5(o)-10.1(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-22.7(.)-23.7(A)-22.7(.)-1( )]TJ 0.009 Tc -0.035 Tw -6.088 -1.2 Td [(D)-30.3(i)-7.3(s)-9.3(p)-20.1(l)-37.8(a)-11(c)-9.7(e)-21(d l)-37.7(a)-18.2(t)-24.7(e)-12.1(r)-30.7(a)-11.4(l r)-19.1(e)-19(c)-41.5(t)-36.8(a)-11.3(l f)-47.1(l)-37.7(a)-8.8(p f)-25.2(o)-11.8(r a)-7.6(n)-7.8(a)-11.4(l f)-62.9(i)-7.4(s)-29.3(t)-22.2(u)-8.4(l)-37.7(a)-26.6(s)-15.5(. )]TJ /T1_1 1 Tf 0.019 Tc -0.019 Tw [(K)13.9(ol)3.6(op)2.4(r)3.2(o)3.4(k)-19.2(t)2.3(ol)3.6(o)-3.3(g)-13.1(i)6.7(a)5.8(.)]TJ /T1_3 1 Tf 0.009 Tc -0.035 Tw 25.759 0 Td [( 2)-8.9(0)-3.8(2)4.2(6)20(;)9.8(2)-1.4(5)1(\()37.7(1)44.3(\))14.5(:)29.3(7)12.7(1)26.4(\226)-23.7(8)-23.3(0)6.5(. \()-0.9(i)-3.2(n R)-6.4(u)-21.9(s)-22.3(s)-15.4(.)43.2(\))10.4(. h)-17.1(t)-49.4(t)-29.4(p)-18.6(s)-8(:)1.9(/)84.7(/)36.5(d)-11.1(o)-12.5(i.)2.7(o)-11.8(r)-16.7(g)-22.7(/)11.2(1)14(0)6.6(.)-5.6(3)7.9(3)-15.9(8)1.3(7)4.7(8/)7.9(2)-8.9(0)9.4(7)-1.9(3)-13.3(-)41.2(7)10.8(55)-8.9(6)-26.7(-)9.8(2)-8.9(0)-3.8(2)4.2(6)-26.7(-)]TJ -0.004 Tc 0.004 Tw -25.759 -1.2 Td [(2)-28.4(5)-50.5(-)28.1(1-)14.2(7)-14.4(1-)-52.2(8)-50.4(0)]TJ /T1_2 1 Tf 0.01 Tc -0.041 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_1 1 Tf 0 Tc -0.036 Tw 10.46 0 Td ( \001\022\n\022\213\022\025 \022\026\r\032 \211\f\020\030\022\026\022\032\ \031\021\022\007, \214\216\221\210 \253\001\215\002\037 \n\031\f\031\033\ \032\031\n\023\031\f\031\b\022\022 \022\026\027\025\022 \003.\001.)Tj /Span<>> BDC ( )Tj EMC (\206\013\255\022\200\273 \215\022\025\016\030\032\020\021\020 \206\031\024\ \024\022\022, \r\f.)Tj /Span<>> BDC ( )Tj EMC (\205\020\f\t\026\020 )Tj 0.023 Tw -10.465 -1.2 Td (\003\030\022\f\t, \030.)Tj /Span<>> BDC ( )Tj EMC (2, \215\031\024\n\021\020, 123423, \206\031\024\024\022\t; e-mail: timur\ nikishin@mail.ru)Tj /T1_2 1 Tf 0.01 Tc 0.012 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_1 1 Tf 0 Tc 0.017 Tw 14.038 0 Td [( Timur V)61(. Nikishin, Ryzhikh N)18(ational Medical R)21(esearch Center of)]TJ /Span<>> BDC ( )Tj EMC [(Colop)46(roctology Salyama Adilya st., 2, Moscow)52(, )]TJ 0.023 Tw -14.043 -1.2 Td [(123423, R)22(ussia; e-mail: timur)-14(nikishin@mail.ru)]TJ 0 Tw 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 05.12.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 05.12.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 188.9979 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0.006 Tc 0.138 Tw 10 0 0 10 70.8661 164.6418 Tm [(\200 \027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \r\f\036 \n\036\ \021\024\007\t )0.5(\b\017\030\031\030\020\017\004\036\f\022\024\020\024 \035\036)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.109 Tw 0 -1.218 TD (\004\036\027\017\016 \253\f\035\024\032\027\t\b\273 \f\r\017\013\036\005\ \023\030\016\n\024\005 \022\017\001\022\017 \n\024\032\027\024 \031\f)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.327 Tw T* (\035\024\r\027\024 \030\026\007\036\035\017\021\034 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\007\r\036 \020\030\031\023\023\t. \025\024\027\006\036\023\021\031\026\035\ \034\027\024\005)6( )]TJ 0.13 Tw T* (\024\f\024\002\036\027\027\024\f\021\034\033 \f\024\r\030\036\n\036\027\027\ \t\b, \021\026\022 \027\026\t\r\026\036\n\t\b \f\235\017\027)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.446 Tw T* [(\022\021\036\030\024\f\002\036\030\036\020\026\033\013\017\b, )0.5(\n\036\021\024\007\024\r )0.5(\016\r\035\016\036\021\f\016 )0.5(\023\030\036\r\026\035\017\030\024)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.372 Tw T* (\r\026\027\017\036 \r\026\032\027\024\f\021\017 \023\024\035\027\024\005\ \017\027\021\026\022\021\027\024\f\021\017 \026\023\017\030\026\021\036\ \035\034)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.229 Tw T* [(\027\024\020\024 \026\023\023\026\030\026\021\026 \023\030\016\n\024\005\ \022\017\001\022\017 \027\026\007 \030\026\007\017\022\026\035\034\027\024\ \f\021\034\033)6( )]TJ 0 Tw T* (\(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj 0 Tc 0.205 Tw 23.244 10.96 Td [(\221\026\022\017\n )0.5(\024\002\030\026\024\n, )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 8.385 0 Td [(\023\030\036\007\f\021\026\r\035\036\027\027\024\005 )0.6(\021\026\002\035\017\006\t )0.6(\r\017\007\027\024, )]TJ 0.506 Tw -8.385 -1.218 Td (\004\021\024 \f\024\r\030\036\n\036\027\027\t\036 \f\235\017\027\022\021\ \036\030\024\f\002\036\030\036\020\026\033\013\017\036 \n\036\021\024\007\ \t )Tj 0.008 Tw T* (\002\036\024\023\026\f\027\t \017)Tj /Span<>> BDC ( )Tj EMC (\027\036\021\030\026\r\n\026\021\017\004\027\t \007\035\016 \003\202\215\ \025, \024\007\027\026\022\024 \017\b \220\235)Tj 0 Tw (-)Tj 0.111 Tw T* (\235\036\022\021\017\r\027\024\f\021\034 \024\f\021\026\r\035\016\036\021\ \032\036\035\026\021\034 \035\031\004\001\036\020\024. \025\030\024\n\036\ \021\024\020\024, )Tj 0.063 Tw T* [(\f\031\013\036\f\021\r\036\027\027\t\n )0.6(\024\020\030\026\027\017\004\036\027\017\036\n )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 13.208 0 Td [(\r\024\n\024\032\027\024\f\021\017 )0.6(\017\b )0.5(\023\030\017)]TJ 0 Tw (-)Tj 0.184 Tw -13.208 -1.218 Td (\n\036\027\036\027\017\016 \024\f\021\026\033\021\f\016 \020\027\024\005\ \027\t\036 \026\021\036\022\017; \r)Tj /Span<>> BDC ( )Tj EMC (\023\024\007\026\r\035\016\033\013\036\n )Tj 0.26 Tw T* [(\002\024\035\034\001\017\027\f\021\r\036 \f\035\031\004\026\036 \021\030\ \036\002\031\036\021\f\016 )0.5(\n\027\024\020\024\220\021\026\023\027\024\036 \035\036\004\036)]TJ 0 Tw (-)Tj 0.089 Tw T* (\027\017\036 \(\007\030\036\027\017\030\031\033\013\026\016 \035\017\020\ \026\021\031\030\026\), \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036, \023\024-\023\030\036\032\027\036\n\031, )Tj 0.621 Tw T* (\027\036\024\002\b\024\007\017\n\024 \023\030\024\r\036\007\036\027\017\036\ \024\021\007\036\035\034\027\024\020\024 \021\030\026\027\f\026\027\026\ \035\034)Tj 0 Tw (-)Tj 0.35 Tw T* (\027\024\020\024 \220\021\026\023\026 \024\023\036\030\026\006\017\017)Tj /Span<>> BDC ( )Tj EMC (\227 \035\017\022\r\017\007\026\006\017\017 \r\027\031\021\030\036\027\027\ \036\020\024 )Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 70.8661 615.7134 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 73.5728 606.7861 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.165 56.0378 Tm (72)Tj ET endstream endobj 1248 0 obj [1257 0 R] endobj 1249 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10.1(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 \212\017\202\t\004\013\ )10.1(\025 \224\005\025\220\025\202\017 )]TJ 0 -1 TD [(\224\004\005\004\024\004\234\004\t\t\217\024 \020\017\026)11(\004\005\017\020\200\t\217\024 \224\005\213\024\025\r\n\204\004\225\t\217\ \024\022\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 43.237 1 Td [(Displaced later)21(al r)31.1(ectal flap for anal f)-20.9(istulas)]TJ ET 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 46.0167 167.4103 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 167.4103 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 46.0167 130.2025 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 43.0197 130.2025 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q BT 0 0 0 1 k /T1_1 1 Tf 10 0 0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-71-80)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 96.0909 695.3259 Tm [(\033\004\212)21(\002\020\200)21(\026)11(\017\026\217 \220\n\005\002\005\013\n\225\004\016\r)10(\025\013)10(\025 \020\004\225\004\t\n\213 \016\b\n\234\004\221 )]TJ -0.607 -1.105 Td [(\212\017\202\t\004\013)10(\025 \224\005\025\220\025\202\017 \224\004\005\004\024\004\234\004\t\t\217\ \024 \020\017\026)11(\004\005\017\020\200\t\217\024 )]TJ 0 Tw 4.291 -1.105 Td [(\224\005\213\024\025\r\n\204\004\225\t\217\024\022)-23.2(\020\025\016\r\002)-19.9(\026)11(\025\024)]TJ 0 0 0 1 k /GS1 gs 14 0 0 14 42.5197 628.822 Tm [(\007\n\r\n\204\n\t\022)-23.2(\032.\021.)]TJ 8.162 0 0 8.162 119.9147 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 124.5506 628.822 Tm [(, \037)31(\025\016)-10(\026)11(\017\005\004\b\022)-23.2(\030.\021.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 214.4659 633.484 Tm [(1,)-69(2)]TJ 0 Tc 0.023 Tw 14 0 0 14 225.7865 628.822 Tm [(, \032)30(\n\026)11(\025\b\022)-23.2(\f)-31(.\207.)]TJ 0 Tw 8.162 0 0 8.162 299.3217 633.484 Tm (1)Tj 0.023 Tw 14 0 0 14 303.9577 628.822 Tm [(, \030\013\t\017\026)11.1(\004\t\r)10(\025\022)-23.3(\235.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 405.1283 633.484 Tm (1)Tj 14 0 0 14 409.7642 628.822 Tm (, )Tj -26.232 -1.143 Td [(\223)42(\017\005\r)10(\025\b\022)-23.3(\240.\240.)]TJ 8.162 0 0 8.162 112.9153 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 117.5513 612.822 Tm [(, \201\017\202\017\204\004\b\022)-23.2(\030.\030.)]TJ 0 Tw 8.162 0 0 8.162 209.6504 617.484 Tm (2)Tj 0.023 Tw 14 0 0 14 214.2863 612.822 Tm [(, \006\n\005\206\r)10(\025\b\022)-23.2(\036.\235.)]TJ 0 Tw 8.162 0 0 8.162 307.3653 617.484 Tm (1)Tj 0.023 Tw 14 0 0 14 312.0013 612.822 Tm [(, \034\004\005\204\n\t\017\022)-23.2(\f)-31(.\240.)]TJ 0 Tw 8.162 0 0 8.162 401.8464 617.484 Tm (1)Tj 14 0 0 14 406.4824 612.822 Tm (, )Tj -25.997 -1.143 Td [(\235\002\202\005\025\b\022)-23.2(\f)-31(.\f)-31(.)]TJ -0.069 Tc 0.069 Tw 8.162 0 0 8.162 118.9066 601.484 Tm [(1,)-69(2)]TJ 0 Tc 0 Tw 5.83 0 0 5.83 42.5197 582.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 579.1527 Tm [(\210\031\006)42(\227 \253\007\235\030\003 \r)10(\025\020\025\224\005\025\r)-9.9(\026)11(\025\020\025\013\n\n \n\024\004\t\n \f)-30.9(.\007.\022)-23.3(\033\217\226\n\220\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\ \n \(\002\020.\022)-23.3(\001\017\020\213\024\017 \f)-20.9(\202\n\020\213, \202.\022)-23.3(2, \013)62.1(.\022)-23.3(\235\025\016\r\b\017, )]TJ -0.331 -1.2 Td [(1)125(23)58(423, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 558.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 555.1527 Tm [(\210\031\006)21(\036)20(\227 \201\034\036 \033)21(\235\f\007\034\036 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\ \002\020.\022)-23.2(\006\017\005\005\n\r\017\202\t\017\213, \202.\022)-23.3(2/1)69(, \016)-10(\026\005)-31(.\022)-23.3(1)69(, \013)62(.\022)-23.2(\235\025\016\r\b\017, 1)125(2)23(5)23(99)35(3, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf 0.058 Tw 9 0 0 9 90.7087 536.6488 Tm [(\037\036\035\034 )0.6(\002\205\205\035\036\220\217\211\003\001\002\226: )0.6(\031\006\027\025\n\020 )0.6(\204\203\203\027\n\023\022\021\025\031\024\023\022 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 20.683 0 Td [(\240\027\016\031\033\020\024\025\031\024\023\022 )0.7(\200\022\032\r\032\b\022\007\027\024\n\031\b\031 )0.5(\026\027\023\031\030\020 )0.5(\f\022\n\021\022\030\020\006\022\022 )0.5(\024\021\022\212\027\235 )]TJ 0.215 Tw -20.683 -1.111 Td (\033\032\t\026\031\235 \n\022\213\n\022 \f\020\023\027\032\020\f\017\025\ \013\026 \033\032\t\026\031\n\022\213\027\007\025\013\026 \f\031\024\n\r\ \023\031\026 \(\035\004\035\) \r)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021 \024\031 \024\021\022\212\020\026\022\ \033\032\t\026\031\235 \n\022\213\n\022, )Tj 0.023 Tw 0 -1.111 TD (\021\031\021\f\027\n\020\005\212\022\026\022 \240\031\f\027\027 1/3 \025\ \020\032\r\255\025\031\b\031 \024\203\022\025\n\023\027\032\020 \(\030\020\ \f\027\027 \253\024\f\031\255\025\013\027\273 \024\021\022\212\022 \033\032\ \t\026\031\235 \n\022\213\n\022\).)Tj 0.338 Tw T* (\004\003\037\002\036\001\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \021)Tj /Span<>> BDC ( )Tj EMC (\031\030\025\031\006\027\025\023\032\031\021\031\027 \033\032\031\024\033\ \027\n\023\022\021\025\031\027 \031\030\025\031\b\032\r\033\033\031\021\031\ \027 \022\024\024\f\027\030\031\021\020\025\022\027 \240\013\f\031 \021\n\ \f\005\007\027\025\031 )Tj 0.05 Tw T* (60)Tj /Span<>> BDC ( )Tj EMC (\033\020\006\022\027\025\023\031\021, \n\031\023\031\032\013\026 \021\013\ \033\031\f\025\027\025\020 \f\022\n\021\022\030\020\006\022\t \024\021\022\ \212\020 \033\032\t\026\031\235 \n\022\213\n\022 \f\020\023\027\032\020\f\ \017\025\013\026 \033\032\t\026\031\n\022\213\027\007\025\013\026 \f\031\ \024\n\r)Tj 0 Tw (-)Tj 0.029 Tw 0 -1.111 TD [(\023\031\026. )0.5(\217\240\024\f\027\030\031\021\020\025\022\027 )0.5(\033\020\006\022\027\025\023\031\021 )0.5(\030\031)]TJ /Span<>> BDC ( )Tj EMC 14.409 0 Td (\022)Tj /Span<>> BDC ( )Tj EMC 0.761 0 Td [(\033\031\024\f\027 )0.5(\031\033\027\032\020\023\022\021\025\031\b\031 )0.5(\021\026\027\213\020\023\027\f\017\024\023\021\020 \033\032\031\021\031\030\ \022\f\031\024\017 )0.5(\033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\033\031\026\031\212\022 \022\025\024\023\032\r)Tj 0 Tw (-)Tj 0.095 Tw -15.17 -1.111 Td (\026\027\025\023\020\f\017\025\013\200 \026\027\023\031\030\031\021)Tj /Span<>> BDC ( )Tj EMC [(\227 \023\032\020\025\024\032\027\n\023\020\f\017\025\031\b\031 )0.5(\r\f\017\023\032\020\016\021\r\n\031\021\031\b\031 )0.5(\022\024\024\f\027\030\031\021\020\025\022\t \(\206\210\207\002\) \022)]TJ /Span<>> BDC ( )Tj EMC (\024\203\022\025\n\023\027\032\031\026\027\023\032\022\022. )Tj -0.023 Tw 0 -1.111 TD [(\004\032\027\021\020\f\022\032\r\005\212\027\027 \n\031\f\022\007\027\024\ \023\021\031 \033\020\006\022\027\025\023\031\021 \022\026\027\f\022 \204\ \n\024\023\032\020\024\203\022\025\n\023\027\032\025\013\235 )0.5(\200\031\030 \024\021\022\212\020 41/60 \(68,3%\). \001\020\f\022\007\022\ \027 \b\025\031\235)]TJ 0 Tw (-)Tj 0.138 Tw T* (\025\031-\021\031\024\033\020\f\022\023\027\f\017\025\013\200 \016\020\023\ \027\n\031\021 \021\013\t\021\f\027\025\013 \r)Tj /Span<>> BDC ( )Tj EMC (39/60 \(65%\), \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \026\025\031\255\027\024\023\021\027\025\025\013\027 \016\ \020\023\027\n\022 \016\020\203\022\n\024\022\032\031\021\020\025\013 )Tj 0.009 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (23/39 \(38,3%\). \217\023\030\020\f\027\025\025\013\027 \032\027\016\r\f\ \017\023\020\023\013 \f\027\007\027\025\022\t \240\013\f\022 \022\016\r\007\ \027\025\013 \007\027\032\027\016 3\23112)Tj /Span<>> BDC ( )Tj EMC (\026\027\024\t\006\027\021. \215\027\030\022\020\025\020 \025\020\240\f\005\ \030\027\025\022\t )Tj 0.096 Tw T* (\024\031\024\023\020\021\022\f\020 7 \(4; 8\) \026\027\024\t\006\027\021\ . \004\027\032\021\022\007\025\031\235 \n\031\025\027\007\025\031\235 \023\ \031\007\n\031\235 \240\013\f\020 \007\020\024\023\031\023\020 \025\027\025\ \020\024\023\r\033\f\027\025\022\t \032\027\006\022\030\022\021\020 \016\ \020\240\031\f\027)Tj 0 Tw (-)Tj 0.238 Tw T* [(\021\020\025\022\t )0.6(\(\204\203\203\027\n\023\022\021\025\031\024\023\017 )0.6(\f\027\007\027\025\022\t\), )0.5(\021\023\031\032\022\007\025\013\026\022)]TJ /Span<>> BDC ( )Tj EMC 20.816 0 Td [(\227 )0.5(\031\006\027\025\n\020 )0.5(\203\r\025\n\006\022\031\025\020\f\017\025\031\b\031 )0.6(\024\031\024\023\031\t\025\022\t )0.5(\016\020\033\022\032\020\023\027\f\017\025\031\b\031 )]TJ -0.033 Tw -20.816 -1.111 Td (\020\033\033\020\032\020\023\020 \033\032\t\026\031\235 \n\022\213\n\022\ ; \021\013\032\020\255\027\025\025\031\024\023\022 \240\031\f\027\021\031\ \b\031 \024\022\025\030\032\031\026\020; \203\020\n\023\031\032\031\021 \ \032\022\024\n\020, \033\032\027\030\033\031\f\031\255\022\023\027\f\017\ \025\031 \021\f\022\t\005\212\022\200 )Tj 0.023 Tw T* (\025\020)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\021\022\023\022\027 \032\027\006\022\030\022\021\020.)Tj 0.044 Tw 0 -1.111 TD [(\206\036\207\210\035\034\003\201: )0.6(\204\203\203\027\n\023\022\021\025\031\024\023\017 )0.6(\026\027\023\031\030\020 )0.6(\035\004\035 )0.5(\024\031\024\023\020\021\022\f\020 )0.6(48/60 )0.5(\(80%; )0.6(95% )0.5(\220\002 )0.5(67,7; )0.5(89,2\) )0.5(\024\f\r\007\020\027\021. )0.5(\001\022 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC 42.512 0 Td (\031\030\025\031\026 )Tj 0.305 Tw -42.512 -1.111 Td (\025\020\240\f\005\030\027\025\022\022 \021)Tj /Span<>> BDC ( )Tj EMC (\033\031\024\f\027\031\033\027\032\020\006\022\031\025\025\031\026 \033\027\ \032\022\031\030\027 \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \024\203\022\025\n\023\027\032\031\026\027\023\032\ \022\022 \022)Tj /Span<>> BDC ( )Tj EMC (\031\006\027\025\n\027 \025\027\030\031\024\023\020\023\031\007\025\031\024\ \023\022 )Tj 0.162 Tw 0 -1.111 TD (\020\025\020\f\017\025\031\b\031 \024\203\022\025\n\023\027\032\020 \033\ \031)Tj /Span<>> BDC ( )Tj EMC (\213\n\020\f\027 Wexner \025\027 \016\020\203\022\n\024\022\032\031\021\020\ \025\031 \r\200\r\030\213\027\025\022\t \203\r\025\n\006\022\022 \030\027\ \032\255\020\025\022\t \(1 \(0; 3\) \240\020\f\f\020 )Tj -0.002 Tw T* (\030\031)Tj /Span<>> BDC ( )Tj EMC 1.208 0 Td [(\031\033\027\032\020\023\022\021\025\031\b\031 )0.5(\021\026\027\213\020\023\027\f\017\024\023\021\020 )0.6(\022)]TJ /Span<>> BDC ( )Tj EMC 13.945 0 Td [(2 )0.5(\(0; )0.5(3\) )0.5(\240\020\f\f\020)]TJ /Span<>> BDC ( )Tj EMC 5.986 0 Td [(\227 )0.5(\007\027\032\027\016 )0.5(3\2316)]TJ /Span<>> BDC ( )Tj EMC 5.421 0 Td (\026\027\024. \(\032)Tj /Span<>> BDC ( )Tj EMC 3.067 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.731 0 Td [(0,68\)\). )0.6(\004\032\022)]TJ /Span<>> BDC ( )Tj EMC 4.859 0 Td [(\031\006\027\025\n\027 )0.6(\203\020\n\023\031\032\031\021 )0.5(\032\022\024\n\020 )]TJ 0.07 Tw -35.218 -1.111 Td (\032\020\016\021\022\023\022\t \032\027\006\022\030\022\021\020 \016\020\ \240\031\f\027\021\020\025\022\t \021\013\t\021\f\027\025\031, \007\023\031\ \024\023\020\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\ \026\031 \024\025\022\255\020\027\023 \204\203\203\027\n\023\022\021\025\ \031\024\023\017 \033\032\022\026\027)Tj 0 Tw (-)Tj 0.02 Tw T* (\025\027\025\022\t \035\004\035 \022\016\240\013\023\031\007\025\020\t \026\ \020\024\024\020 \023\027\f\020 \(\033\032\022 \022\025\030\027\n\024\027\ \026\020\024\024\013 \023\027\f\020)Tj /Span<>> BDC ( )Tj EMC (\241)Tj /Span<>> BDC ( )Tj EMC (30,7 \n\b/\026\262\) \(\031\023\025\031\213\027\025\022\027 \213\020\025\ \024\031\021 \(\217\237\))Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (1,14 )Tj 0.048 Tw T* (\(95% \030\031\021\027\032\022\023\027\f\017\025\013\235 \022\025\023\027\ \032\021\020\f \(\220\002\) 1,02; 1,29\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,02\), \b\025\031\235\025\013\027 \016\020\023\027\n\022 \021)Tj /Span<>> BDC ( )Tj EMC (\026\027\255\024\203\022\025\n\023\027\032\025\031\026 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (5,50 )Tj 0.002 Tw T* (\(95% \220\002 1,14; 26,6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,03\), \022\213\022\031\020\025\020\f\017\025\031\026 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (16,8 \(95% \220\002 3,20; 7,55\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,0009\) \022)Tj /Span<>> BDC ( )Tj EMC (\033\027\f\017\021\022\031\032\027\n\023\020\f\017)Tj 0 Tw (-)Tj 0.08 Tw T* (\025\031\026 \(\217\237)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (7,86 \(95% \220\002 1,69; 36,6\), \032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,008\) \033\032\031\024\023\032\020\025\024\023\021\020\200, \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \026\025\031\255\027\024\023\021\027\025\025\013\027 \ \b\025\031\235\025\013\027 \016\020\023\027\n\022 )Tj 0.096 Tw 0 -1.111 TD (\(\217\237)Tj /Span<>> BDC ( )Tj EMC 2.102 0 Td (=)Tj /Span<>> BDC ( )Tj EMC [(4,40 )0.5(\(95% \220\002 )0.5(1,14; )0.5(16,9\), \032)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC 13.536 0 Td [(0,03\). )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC [(\023\031 )0.5(\255\027 \021\032\027\026\t, )0.5(\026\027\023\031\030 )0.5(\035\004\035 )0.5(\033\031\016\021\031\f\022\f )0.5(\030\031\240\022\023\017\024\t \021\013\016\030\031\032\031\021\f\027\025\ \022\t )]TJ 0.052 Tw -15.638 -1.111 Td (\r)Tj /Span<>> BDC ( )Tj EMC (28/39)Tj /Span<>> BDC ( )Tj EMC (\(71,8%\) \033\020\006\022\027\025\023\031\021 \024)Tj /Span<>> BDC ( )Tj EMC (\b\025\031\235\025\013\026\022 \016\020\023\027\n\020\026\022, \033\032\022\ \007\027\026 \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\025\020\f\022\007\022\022 \026\025\031\255\027\024\023\021\027\025\025\013\ \200 \016\020\023\027\n\031\021 \024\021\022\212 \r\030\020)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\f\031\024\017 \f\022\n\021\022\030\022\032\031\021\020\023\017 \021)Tj /Span<>> BDC ( )Tj EMC (15/23)Tj /Span<>> BDC ( )Tj EMC (\(65,2%\) \024\f\r\007\020\t\200.)Tj 0.096 Tw T* (\207\003\202\035\224\232\036\001\002\036: \026\027\023\031\030 \035\004\035\ \033\031\016\021\031\f\t\027\023 \031\030\025\031\204\023\020\033\025\031\ \f\022\n\021\022\030\022\032\031\021\020\023\017 \253\024\f\031\255\025\ \013\027\273 \024\021\022\212\022 \033\032\t\026\031\235 \n\022\213\n\022\ \021)Tj /Span<>> BDC ( )Tj EMC (80% )Tj 0.068 Tw T* (\025\020\240\f\005\030\027\025\022\235, \033\032\022)Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026, \025\027 \r\200\r\030\213\020\t \203\r\025\n\006\022\031\ \025\020\f\017\025\031\b\031 \024\031\024\023\031\t\025\022\t \016\020\033\ \022\032\020\023\027\f\017\025\031\b\031 \020\033\033\020\032\020\023\020\ \033\032\t\026\031\235 \n\022\213\n\022. )Tj 0.124 Tw T* (\221\031\f\027\021\031\235 \024\022\025\030\032\031\026, \021)Tj /Span<>> BDC ( )Tj EMC (\024\032\027\030\025\027\026, \025\027 \033\032\027\021\013\213\020\f \253\ \024\f\020\240\031\b\031\273 \r\032\031\021\025\t \031\212\r\212\027\025\ \022\235, \033\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \021\022\016\r\020\f\017\025\031-\020\025\020\f\ \031\b\031\021\031\235 )Tj -0.025 Tw T* (\213\n\020\f\013 \240\031\f\022. \004\031)Tj /Span<>> BDC ( )Tj EMC (\030\020\025\025\013\026 \021\022\016\r\020\f\017\025\031-\020\025\020\f\ \031\b\031\021\031\235 \213\n\020\f\013 \240\031\f\022, \026\027\030\022\ \020\025\020 \240\020\f\f\031\021 \025\027 \033\032\027\021\013\213\020\f\ \020 3-\200 \016\020)Tj /Span<>> BDC ( )Tj EMC (\021\027\024\017 \033\027\032\022\031\030 )Tj 0.078 Tw T* (\025\020\240\f\005\030\027\025\022\t, \007\023\031 \024\031\031\023\021\027\ \023\024\023\021\r\027\023 \024\f\020\240\031\026\r \r\032\031\021\025\005\ \240\031\f\027\021\013\200 \031\212\r\212\027\025\022\235; \033\032\022\ )Tj /Span<>> BDC ( )Tj EMC (\204\023\031\026 \026\020\n\024\022\026\020\f\017\025\020\t \022\025\023\ \027\025\024\022\021)Tj 0 Tw (-)Tj 0.051 Tw T* (\025\031\024\023\017 \240\013\f\020 \031\023\026\027\007\027\025\020 \025\ \020)Tj /Span<>> BDC ( )Tj EMC (2\2314)Tj /Span<>> BDC ( )Tj EMC (\024\r\023\n\022 \033\031\024\f\027 \031\033\027\032\020\006\022\022, \023\ \031\b\030\020 \n\020\n \n)Tj /Span<>> BDC ( )Tj EMC (10 \024\r\023\n\020\026 \033\032\020\n\023\022\007\027\024\n\022 \021\024\ \027 \033\020\006\022\027\025\023\013 \025\027 )Tj 0.023 Tw 0 -1.111 TD (\022\024\033\013\023\013\021\020\f\022 \240\031\f\027\021\013\200 \031\212\ \r\212\027\025\022\235.)Tj /T1_2 1 Tf 0.01 Tc -0.005 Tw 8 0 0 8 42.5596 201.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0 Tw 8.47 0 Td ( \024\021\022\212 \033\032\t\026\031\235 \n\022\213\n\022, \205\004\202,\ \f\020\023\027\032\020\f\017\025\013\235 \033\032\t\026\031\235 \n\022\213\ \027\007\025\013\235 \f\031\024\n\r\023, \035\004\035, \f\022\n\021\022\030\ \020\006\022\t \024\021\022\212\020 \033\032\t\026\031\235, \b\025\031\235\ \025\013\027 \016\020\023\027\n\022, )Tj 0.023 Tw -8.475 -1.2 Td (\033\032\027\021\027\025\023\022\021\025\020\t \f\022\b\020\023\r\032\020\ , \025\027\030\031\024\023\020\023\031\007\025\031\024\023\017 \020\025\020\ \f\017\025\031\b\031 \024\203\022\025\n\023\027\032\020, \001\003\205)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.017 Tc -0.04 Tw -10.401 -2.617 Td [(\020\036\017)5.3( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.007 Tc -0.035 Tw 8.866 0 Td ( \203\017\022\017\001\017\027)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \025\024\f\021\026\030\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\200., \221\017\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \230\020\027\026\021\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \240\026\030\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\213.\213., \212\026\007\026\001\036\r)Tj /Span<>> BDC ( )Tj EMC (\230.\230., \207\017\030\033\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \215\036\030\001\017\027\026)Tj /Span<>> BDC ( )Tj EMC [(\202.\213.,)7( )]TJ 0.023 Tc -0.014 Tw -8.871 -1.2 Td (\204\031\007\030\024\r)Tj /Span<>> BDC ( )Tj EMC [(\202.\202. \217\036\031\035\034\021\026\021\t \b\017\030\031\030\020\017\ \004\036\f\022\024\020\024 \035\036\004\036\027\017\016 \f\r\017\013\036\ \005 \026\007\027\036\020\024 \023\030\024\b\024\007\026 \023\036\030\036\ \n\036\013\036\027\027\t\n \035\026\021\036\030\026\035\034\027\t\n \023\ \030\016\n\024\022\017\001\036\004\027\t\n \035\024\f\022\031\021\024\n.\ )23( )]TJ /T1_1 1 Tf -0.023 Tw 0 -1.2 TD (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.024 Tw ( 2026; \021.)Tj /Span<>> BDC ( )Tj EMC (25, \223)Tj /Span<>> BDC ( )Tj EMC 14.78 0 Td (1, \f.)Tj /Span<>> BDC ( )Tj EMC (71\22680. https://doi.org/10.33878/2073-7556-2026-25-1-71-80)Tj ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 545.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tc 0 Tw 9 0 0 9 47.6607 536.226 Tm (\021\033\r\035\f\033)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.0519 56.0378 Tm (71)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 0.311 c -1.142 0.229 -1.202 0.131 -1.24 0.024 c -1.29 -0.132 -1.312 -0.296 -1.304 -0.459 c -1.304 -0.569 -1.292 -0.677 -1.267 -0.784 c -1.244 -0.885 -1.202 -0.983 -1.145 -1.07 c -1.09 -1.154 -1.016 -1.224 -0.93 -1.275 c -0.833 -1.33 -0.722 -1.356 -0.611 -1.352 c -0.457 -1.357 -0.307 -1.301 -0.194 -1.195 c -0.078 -1.077 -0.005 -0.922 0.011 -0.757 c 0.587 -0.757 l 0.556 -1.055 0.419 -1.332 0.202 -1.538 c -0.022 -1.721 -0.306 -1.815 -0.595 -1.803 c -0.777 -1.806 -0.958 -1.771 -1.126 -1.7 c -1.293 -1.642 -1.445 -1.547 -1.57 -1.421 c -1.68 -1.297 -1.763 -1.151 -1.814 -0.993 c -1.87 -0.822 -1.898 -0.643 -1.896 -0.462 c -1.898 -0.276 -1.871 -0.091 -1.817 0.087 c -1.766 0.252 -1.682 0.405 -1.57 0.537 c -1.459 0.664 -1.323 0.766 -1.168 0.834 c -0.991 0.914 -0.798 0.955 -0.603 0.954 c -0.457 0.954 -0.311 0.935 -0.17 0.895 c -0.039 0.858 0.084 0.799 0.194 0.72 c 0.302 0.643 0.393 0.543 0.459 0.428 c 0.531 0.298 0.572 0.155 0.582 0.008 c 0 0.008 l 0 0 l f Q q 1 0 0 1 394.8712 733.5723 cm 0 0 m 0.577 0 l 0.577 -2.048 l 1.615 -0.985 l 2.322 -0.985 l 1.323 -1.944 l 2.417 -3.604 l 1.716 -3.604 l 0.919 -2.337 l 0.577 -2.669 l 0.577 -3.604 l 0 -3.604 l h f Q q 1 0 0 1 398.712 732.5762 cm 0 0 m 0.436 0 l 0.436 0.218 l 0.429 0.352 0.448 0.486 0.488 0.614 c 0.521 0.705 0.577 0.786 0.651 0.85 c 0.717 0.905 0.795 0.943 0.879 0.961 c 0.966 0.979 1.056 0.988 1.145 0.988 c 1.28 0.993 1.416 0.981 1.548 0.954 c 1.548 0.505 l 1.509 0.516 1.469 0.523 1.429 0.528 c 1.379 0.532 1.33 0.532 1.28 0.528 c 1.209 0.53 1.14 0.511 1.081 0.473 c 1.019 0.419 0.987 0.337 0.999 0.255 c 0.999 -0.011 l 1.498 -0.011 l 1.498 -0.441 l 1.009 -0.441 l 1.009 -2.622 l 0.436 -2.622 l 0.436 -0.428 l 0.005 -0.428 l 0.005 0 l 0 0 l f Q q 1 0 0 1 401.7535 729.8965 cm 0 0 m -0.191 -0.003 -0.381 0.032 -0.559 0.104 c -0.715 0.167 -0.856 0.264 -0.972 0.388 c -1.091 0.512 -1.181 0.659 -1.238 0.82 c -1.356 1.18 -1.356 1.567 -1.238 1.925 c -1.181 2.087 -1.091 2.234 -0.972 2.358 c -0.856 2.481 -0.715 2.578 -0.559 2.643 c -0.199 2.78 0.198 2.78 0.558 2.643 c 0.714 2.578 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(\025\024\n\026\030\024\r \212\n\017\021\030\017\005 \202\035\036\022\f\026\ \027\007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\031\007\036\027\021 6 \022\031\030)Tj 0 Tw (-)Tj 0.485 Tw T* (\f\026 \023\036\007\017\026\021\030\017\004\036\f\022\024\020\024 \235\026\ \022\031\035\034\021\036\021\026 \205\206\207\210\211 \200\210 \025\206\204\ \211 )Tj 0 Tw T* (\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; ORCID 0009-0008-11\ 42-5430)Tj /T1_1 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_0 1 Tf 0 Tw 0 -1.218 TD [(V)-15(ic)-16(t)17(or A. L)-31.9(a)-24(zar)-23.9(enko)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-2069-7701)Tj 0 -1.218 TD [(Dmi)-24(tr)-36.9(iy A. Sever)-36.9(inov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4460-1353)Tj 0 -1.218 TD [(V)-15(ia)-17(chesl)-15.9(av A. L)-32(ip)32(a)15(t)17.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-6121-7412)Tj T* [(T)40(a)15(t)-10(y)22(ana N. K)25.1(udr)-24(y)22(av)-24(tsev)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-1009-3004)Tj T* [(Dmi)-24(tr)-23.9(y A. Sever)-36.9(inov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0003-4460-1353)Tj T* [(Dmi)-24(tr)-23.9(y A. K)25(omar)-32(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0008-1142-5430)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 566.5159 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.203 Tw 8 0 0 8 70.8661 553.6812 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(W)-16(inst)17(on)]TJ /Span<>> BDC ( )Tj EMC [(DEM, P)-24(ina)]TJ /Span<>> BDC ( )Tj EMC [(N, K)-16(asp)25.1(r)-24(zyck)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(T, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. A)Tj /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-23.9(ev)-16(iew )]TJ -0.042 Tw -1.296 -1.25 Td (of)Tj /Span<>> BDC ( )Tj EMC 1.006 0 Td [(single-l)-15.9(a)15(yer )0.5(ver)-10(sus )0.5(d)-16(ouble-l)-16(a)15.1(yer intest)-31.9(inal )0.5(anast)17(omosis: )0.5(is )0.5(one be)-11.9(t)]TJ 0 Tw (-)Tj -1.006 -1.25 Td (ter? )Tj /T1_3 1 Tf -0.009 Tw 1.784 0 Td [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surgical R)21.1(esearch)]TJ /T1_0 1 Tf [(. 2024;302:606\226610. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj -1.784 -1.25 Td (jss.2024.07.105)Tj 0 0 0 1 k /GS1 gs 0.267 Tw 0 -1.25 TD (2.)Tj /Span<>> BDC ( )Tj EMC [(Anir)-21.9(ut)-13(han)]TJ /Span<>> BDC ( )Tj EMC [(D, P)35(r)-33(anav)-16(i)]TJ /Span<>> BDC ( )Tj EMC [(AR, Sr)-24(eena)15(t)-12.9(h)]TJ /Span<>> BDC ( )Tj EMC [(GS, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. Ef)-55.9(f)-28(ica)-17(cy of)]TJ /Span<>> BDC ( )Tj EMC (sin)Tj 0 Tw (-)Tj 0.001 Tc 0.35 Tw T* [(gle l)-16.4(a)14.6(yer)-24.4(ed intest)-32.4(inal anast)16.6(omosis over d)-16.4(ouble l)-16.4(a)14.6(yer)-24.4(ed intest)-32.4(i)]TJ 0 Tc 0 Tw (-)Tj 0.006 Tc 0.35 Tw T* [(nal anast)16.7(omosis-an open l)-16.3(abelled, r)-33.3(and)-16.3(omized contr)-32.3(olled tr)-37.3(ial.)6( )]TJ /T1_3 1 Tf 0 Tc 0.102 Tw T* [(Inter)-14(national Jour)-14(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Surg)12(er)-43(y)]TJ /T1_0 1 Tf [(. 2020;78:173\226178. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1016/j.)Tj T* (ijsu.2020.04.066)Tj 0 0 0 1 k /GS1 gs 0.01 Tc 0.372 Tw T* (3.)Tj /Span<>> BDC ( )Tj EMC 1.326 0 Td (\202\020\026\036\r)Tj /Span<>> BDC ( )Tj EMC 2.992 0 Td [(\233.\025., )0.5(\230\f\n\026\005\t\035\024\r\026)]TJ /Span<>> BDC ( )Tj EMC 8.33 0 Td [(\003.\233., )0.5(\204\026\n\036\007\024\r)]TJ /Span<>> BDC ( )Tj EMC 6.692 0 Td [(\221.\233. )0.6(\215\030\024\235\017\035\026\022\021\017\022\026)10( )]TJ 0 Tc 0.133 Tw -19.34 -1.25 Td [(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.5(\001\r\024\r \022\017\001\036\004\027\t\b \026\027\026\f\021\024\n\024\024\ \r. )]TJ /T1_3 1 Tf [(\001\031\021\031\024\023\022 )0.5(\200\022\032\r\032)]TJ 0 Tw (-)Tj 0.011 Tc -0.011 Tw T* (\b\022\022)Tj /T1_0 1 Tf 0.417 Tw [(. 2022;30\(1\):86\22694. d)-16.2(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs -0.011 Tw (10.18484/2305-0047.2022.1.86)Tj 0 0 0 1 k /GS1 gs 0 Tc 0.428 Tw ( / )Tj 0.188 Tw T* [(A)-25(gha)15(yev)]TJ /Span<>> BDC ( )Tj EMC [(E.K., Is)26(ma)15(yil)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(Z.E., Mamed)-16(ov)]TJ /Span<>> BDC ( )Tj EMC [(T.E. P)35(r)-24(event)-31.9(ion of)]TJ /Span<>> BDC ( )Tj EMC [(sutur)-24(e )]TJ 0.019 Tc 0.678 Tw T* [(insuf)-55.7(f)-27.7(ic)-23.6(iency in intest)-31.7(inal anast)17.3(omoses. )]TJ /T1_3 1 Tf [(N)17.3(ov)13.3(osti Khirurgii)]TJ /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.023 Tw T* [(2022;30\(1\):86\22694. \(In Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18484/2305-0047.2022.1.86)Tj 0 0 0 1 k /GS1 gs 0.242 Tw T* (4.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(U)13(pp)32(al)]TJ /Span<>> BDC ( )Tj EMC [(A, P)-23.9(iga)-24(z)-24(zi)]TJ /Span<>> BDC ( )Tj EMC [(A. New technol)30.1(o)-16(gies t)17(o)]TJ /Span<>> BDC ( )Tj EMC [(p)25(r)-24(event anast)17(omo)17(t)-32(ic )]TJ 0 Tw -1.296 -1.25 Td (leak. )Tj /T1_3 1 Tf 0.18 Tw 2.345 0 Td [(Clin Colon R)21(ectal Surg)]TJ /T1_0 1 Tf [(. 2021;34\(6\):379\226384. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 20.813 0 Td (10.1055/s-)Tj -23.158 -1.25 Td (0041-1735268)Tj 0 0 0 1 k /GS1 gs -0.027 Tw T* (5.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(R)-10(adu)]TJ /Span<>> BDC ( )Tj EMC [(ER, V)29(oicu)]TJ /Span<>> BDC ( )Tj EMC [(SI, T)47(hakur)]TJ /Span<>> BDC ( )Tj EMC [(VK. P)10(ol)35(ymer)-37(ic membr)-33(anes for biomedical )]TJ 0 Tw -1.296 -1.25 Td [(appl)-31(ica)15(t)-31.9(ions. )]TJ /T1_3 1 Tf 5.544 0 Td [(P)15(olymers)]TJ /T1_0 1 Tf 0.023 Tw (. 2023;15)Tj /T1_3 1 Tf 0 Tw (:)Tj /T1_0 1 Tf 0.023 Tw [(619. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.3390/pol)35(ym15030619)]TJ 0 0 0 1 k /GS1 gs 0.017 Tc 0.62 Tw -5.544 -1.25 Td (6.)Tj /Span<>> BDC ( )Tj EMC 1.347 0 Td (\037\t\023\035\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\025.\206., \212\036\027\017\f\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\214., \206\026\017\027)Tj /Span<>> BDC ( )Tj EMC (\224.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)17( )]TJ 0.009 Tc 0.35 Tw -1.347 -1.25 Td (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \024\002\ \024\f\027\024\r\026\027\017\036 \023\030\017\n\036\027\036\027\017\016 \ \n\036\021\024\007\024\r \002\017\024\035\024)Tj 0 Tc 0 Tw (-)Tj 0.008 Tc 0.35 Tw T* (\020\017\004\036\f\022\024\005 \026\013\017\021\t \021\024\035\f\021\024\ \022\017\001\036\004\027\024\020\024 \026\027\026\f\021\024\n\024\026, \ \f\235\024\030\n\017\030\024\r\026\027)Tj 0 Tc 0 Tw (-)Tj 0.247 Tw T* (\027\024\020\024 \r)Tj /Span<>> BDC ( )Tj EMC (\031\f\035\024\r\017\016\b \035\026\023\026\030\024\f\022\024\023\017\004\ \036\f\022\017 \026\f\f\017\f\021\017\030\024\r\026\027\027\024\005 \024\ \023\036\030\026\006\017\017. )Tj /T1_3 1 Tf 0.045 Tw T* (\225\022\032\r\032\b\022\t. \211\031\024\023\031\007\025\020\t \036\021\032\ \031\033\020)Tj /T1_0 1 Tf [(. 2023;2\(12\):158\226175. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.34883/)Tj T* (PI.2023.12.2.019)Tj 0 0 0 1 k /GS1 gs 0.046 Tw [( / T)60(sypl)-16(akov)]TJ /Span<>> BDC ( )Tj EMC (K.G., Denisenko)Tj /Span<>> BDC ( )Tj EMC [(V.L., Gain Y)34.9(u.M., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.008 Tw T* [(E)35(xper)-37(iment)15.1(al subst)15.1(ant)-32(ia)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(biol)30(o)-16(gical p)25(r)-32(o)17(tec)-16(t)-32(ion me)-12(t)-13(hods appl)35.1(y)]TJ 0 Tw 27.286 0 Td (-)Tj 0.028 Tw -27.286 -1.25 Td [(ing for col)30(onic anast)17(omosis for)-16(med under condi)-23.9(t)-32(ions of)]TJ /Span<>> BDC ( )Tj EMC [(l)-15.9(ap)32(ar)-32(oscopi)]TJ 0 Tw (-)Tj 0.001 Tw T* [(call)35(y assisted sur)-32(ger)-23.9(y. )]TJ /T1_3 1 Tf [(Surg)12(er)-43(y. Easter)-14(n Europe)]TJ /T1_0 1 Tf (. 2023;2\(12\):158\226175. )Tj 0.023 Tw T* [(\(in Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.34883/PI.2023.12.2.019)Tj 0 0 0 1 k /GS1 gs 0.219 Tw T* (7.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\024\004\036\021\t\020\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\203.\207., \204\036\007\r\036\007\036\r\026)Tj /Span<>> BDC ( )Tj EMC [(\214.\200. \217\036\031\035\034\021\026\021\t )0.5(\f\030\026\r\027\017\021\036\035\034\027\024\020\024 )]TJ 0.285 Tw -1.296 -1.25 Td [(\026\027\026\035\017\026 )0.5(\002\017\024\035\024\020\017\004\036\f\022\024\005 )0.6(\020\036\030\n\036\021\017\004\027\024\f\021\017 )0.6(\001\r\024\r )0.5(\032\036\035\031\007\022\026 )0.5(\031)]TJ /Span<>> BDC ( )Tj EMC 24.783 0 Td (\022\024\001\036\022. )Tj /T1_3 1 Tf 0.012 Tc 0.456 Tw -24.783 -1.25 Td (\002\016\021\027\024\023\022\t \215\027\255\030\r\025\020\032\031\030\025\ \031\235 \020\n\020\030\027\026\022\022 \020\b\032\020\032\025\031\b\031\ \031\240\032\020\016\031\021\020\025\022\t)Tj /T1_0 1 Tf 0 Tc 0 Tw (. )Tj 0.282 Tw T* [(2018;42\(20\):88\22691. / K)25.1(o)-16(che)-12(t)-10(ygov)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(N.B., Med)-17(vedev)-15(a)]TJ /Span<>> BDC ( )Tj EMC [(L.V. R)13(esul)56.1(ts )]TJ 0.01 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(com)10(p)32(ar)-33(a)15(t)-32(i)-16(ve anal)35(y)-12.9(sis of)]TJ /Span<>> BDC ( )Tj EMC [(t)-12.9(he biol)30(o)-15.9(gical t)-32(ightness of)]TJ /Span<>> BDC ( )Tj EMC [(gastr)-37(ic sutur)-24(es )]TJ 0.189 Tw T* [(in ca)15(ts. )]TJ /T1_3 1 Tf [(N)18(e)10(ws of)]TJ /Span<>> BDC ( )Tj EMC [(the Inter)-13.9(national Academ)11(y of)]TJ /Span<>> BDC ( )Tj EMC [(A)11(g)14(rar)-36.9(ian Education. )]TJ /T1_0 1 Tf 0.023 Tw T* (2018;42\(20\):88\22691. \(in Russ.\).)Tj 0.137 Tw T* (8.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\204\024\f\024\035\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\202.\200., \204\031\021\024\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\200., \206\031\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\222.\200., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \222\024\r\030\036\n\036\027\027\t\036 )Tj 0.018 Tc 0.65 Tw -1.296 -1.25 Td (\f\023\024\f\024\002\t \027\026\035\024\032\036\027\017\016 \022\017\001\ \036\004\027\024\020\024 \001\r\026. )Tj /T1_3 1 Tf [(\001\020\r\007\025\031\027 \031\240\031\016\032\027\025\022\027.)18( )]TJ 0 Tc 0.188 Tw T* [(\215\027\030\022\006\022\025\024\n\022\027 )0.6(\025\020\r\n\022)]TJ /T1_0 1 Tf [(. )0.5(2024;2:43\22648. )0.6(/ )0.6(M)-24(osol)30(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 20.286 0 Td [(A.V., )0.6(Mut)17(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC 5.614 0 Td (T.V., )Tj 0.094 Tw -25.9 -1.25 Td (Gunov)Tj /Span<>> BDC ( )Tj EMC [(S.V., e)-11.9(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-24(oder)-15(n me)-12(t)-13(hods of)]TJ /Span<>> BDC ( )Tj EMC [(intest)-31.9(inal sutur)-37(ing. )]TJ /T1_3 1 Tf 0 Tw [(Scientif)-43(ic )]TJ 0.023 Tw T* [(revie)10(w. Medical sciences)]TJ /T1_0 1 Tf (. 2024;2:43\22648. \(in Russ.\))Tj 0.295 Tw T* (9.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td [(S)-24(co)17(t)-30(t)]TJ /Span<>> BDC ( )Tj EMC [(BB, W)12(ang)]TJ /Span<>> BDC ( )Tj EMC [(Y, W)16(u)]TJ /Span<>> BDC ( )Tj EMC [(R, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. L)-31.9(ight)]TJ /Span<>> BDC (-)Tj EMC [(a)-17(c)-16(t)-32(i)-16(v)-15(a)15.1(ted pho)17(t)17(oseal)-30.9(ing )]TJ 0.108 Tw -1.296 -1.25 Td [(wi)-24(t)-13(h human amnio)17.1(t)-32(ic membr)-33(ane str)-24(eng)17(t)-12.9(hens bo)-14(wel anast)17(omosis in )]TJ 0.136 Tw T* (a)Tj /Span<>> BDC ( )Tj EMC 0.832 0 Td [(hypo)17(tensi)-15.9(ve, tr)-32.9(auma)]TJ /Span<>> BDC (-)Tj EMC [(r)-24(elev)-14.9(ant )0.5(swine )0.5(model. )]TJ /T1_3 1 Tf 18.11 0 Td [(Lasers )0.5(in )0.5(Surg)12(er)-43(y )0.5(and )]TJ 0 Tw 10.114 55 Td (Medicine)Tj /T1_0 1 Tf 0.023 Tw [(. 2022;3\(54\):407\226417. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.1002/ls)26(m.23485)]TJ 0 0 0 1 k /GS1 gs 0.011 Tc 0.424 Tw T* (10.)Tj /Span<>> BDC ( )Tj EMC 1.842 0 Td (\230\027\026\030\b\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \214\017\023\026\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \003\026\021\024\035\024\022\017\027\026)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)11.1( )]TJ 0.019 Tc 0.703 Tw -1.842 -1.25 Td (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \024\002\ \024\f\027\024\r\026\027\017\036 \220\235\235\036\022\021\017\r\027\024\f\ \021\017 \023\030\017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.208 Tw T* (\027\017\016 \027\024\r\t\b \023\024\035\017\n\036\030\027\t\b \n\036\n\002\ \030\026\027 \007\035\016 \020\036\030\n\036\021\017\026\006\017\017 \035\ \017\027\017\017 \001\r\024\r )Tj 0.246 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \021\024\035\f\021\024\022\017\ \001\036\004\027\t\b \026\027\026\f\021\024\n\024\024\r. )Tj /T1_3 1 Tf (\211\027\024\023\025\022\n \204\n\024)Tj 0 Tw (-)Tj 0.01 Tc 0.37 Tw T* (\033\027\032\022\026\027\025\023\020\f\017\025\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\n\f\022\025\022\007\027\024\n\031\235 \200\022\032\r\032\b\022\022)Tj /T1_0 1 Tf [(. 2016;3:176\226180. /)10( )]TJ 0 Tc 0.301 Tw T* [(M)-24(osol)30(ov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(A.V., Mut)17(ov)-15(a)]TJ /Span<>> BDC ( )Tj EMC (T.V., Gunov)Tj /Span<>> BDC ( )Tj EMC [(S.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. M)-23.9(oder)-15(n me)-12(t)-13(hods )]TJ 0.005 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(intest)-32(inal sutur)-36.9(ing. )]TJ /T1_3 1 Tf [(Scientif)-43(ic revie)10.1(w. Medical sciences)]TJ /T1_0 1 Tf (. 2024;2:43\226)Tj 0.023 Tw T* (48. \(in Russ.\).)Tj 0.007 Tc 0.349 Tw T* (11.)Tj /Span<>> BDC ( )Tj EMC 1.824 0 Td [(\215\026\021\036\027\021 \223 2813120 C1 \217\024\f\f\017\005\f\022\026\016\ \205\036\007\036\030\026\006\017\016, \204\215\025 A61L)7.1( )]TJ 0 Tc 0.138 Tw -1.824 -1.25 Td (15/24, A61L 15/28, A61L 15/44. \216\017\030\031\030\020\017\004\036\f\022\ \026\016 \023\024\035\017\n\036\030\027\026\016 \n\036\n)Tj 0 Tw (-)Tj 0.118 Tw T* (\002\030\026\027\026 : \223 2023127789 : \026\016\r\035. 27.10.2023 : \024\ \023\031\002\035. 06.02.2024 / )Tj 0.082 Tw T* (\200.\215.)Tj /Span<>> BDC ( )Tj EMC (\206\026\r\030\017\035\033\022, \200.\202.)Tj /Span<>> BDC ( )Tj EMC (\214\017\023\026\021\024\r, \213.\222.)Tj /Span<>> BDC ( )Tj EMC [(\204\017\001\017\027\026 \017 \f\024\026\r\021. 11. P)40(a)15(tent N)-14(o. )]TJ 0.097 Tw T* [(2813120 C1 Russian F)10(eder)-33(a)15(t)-32(ion, IPC A61L 15/24, A61L 15/28, A61L )]TJ 0.099 Tw T* [(15/44. Sur)-31.9(gical pol)35(ymer membr)-33(ane : N)-14(o. 2023127789 : appl)-30.9(ica)15(t)-32(ion )]TJ 0.201 Tw T* [(27.10.2023 : publ)-31(ished 06.02.2024 / V.P.)]TJ /Span<>> BDC ( )Tj EMC [(Gavr)-36.9(il)35(yuk, V.A.)]TJ /Span<>> BDC ( )Tj EMC [(L)-32(ip)32(a)15(t)17(ov, )]TJ 0.023 Tw T* (E.S.)Tj /Span<>> BDC ( )Tj EMC [(Mishina e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al.)Tj 0.08 Tw T* (12.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td (\217\036\026\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\215.\202., \206\030\017\r\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\222.\206. \233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\026\016\ \024\006\036\027\022\026 \n\036\b\026)Tj 0 Tw (-)Tj 0.188 Tw -1.796 -1.25 Td [(\027\017\004\036\f\022\017\b \023\030\024\004\027\024\f\021\027\t\b \f\r\ \024\005\f\021\r \023\030\036\006\017\017\024\027\027\t\b )0.5(\024\007\027\024\030\016\007\027\t\b \n\036\032)]TJ 0 Tw (-)Tj 0.073 Tw T* [(\022\017\001\036\004\027\t\b )0.5(\026\027\026\f\021\024\n\024\024\r. )]TJ /T1_3 1 Tf 10.29 0 Td [(\020\021\032\022\007\027\024\n\022\235 )0.5(\026\027\030\022\n\031-\240\022\031\f\031\b\022\007\027\024\n\022\235 )0.6(\021\027\024\023)]TJ 0 Tw (-)Tj -10.29 -1.25 Td (\025\022\n)Tj /T1_0 1 Tf 0.015 Tw [(. 2020;3\(23\):67\22672. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.29039/2070-8092-2020-23-3-67-72)Tj 0 0 0 1 k /GS1 gs ( )Tj 0.017 Tw T* [(/ )0.5(R)13(ezanov)]TJ /Span<>> BDC ( )Tj EMC 4.268 0 Td [(P.A., )0.5(G)20(r)-36.9(i)-16(venko)]TJ /Span<>> BDC ( )Tj EMC 5.882 0 Td [(S.G. )0.5(E)35(xper)-36.9(iment)15(al )0.5(ev)-15(al)35(ua)15(t)-32(ion )0.5(of)]TJ /Span<>> BDC ( )Tj EMC 12.924 0 Td (mechanical )Tj 0.02 Tw -23.074 -1.25 Td [(str)-23.9(enght p)25(r)-32(oper)-22(t)-32(ies in p)25(r)-23.9(ec)-24(ise single-l)-15.9(a)15(yer)-24(ed intest)-32(inal anast)17(omosis. )]TJ /T1_3 1 Tf -0.031 Tw T* [(T)54(aur)-37(ide )0.6(Medical )0.6(and )0.6(Biological )0.6(Bulletin)]TJ /T1_0 1 Tf [(. )0.5(2020;3\(23\):67\22672. )0.6(\(in )0.5(Russ.\). )]TJ 0 Tw T* [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td (10.29039/2070-8092-2020-23-3-67-72)Tj 0 0 0 1 k /GS1 gs 0.012 Tc 0.425 Tw -1.847 -1.25 Td [(1)0.5(3)0.5(.)]TJ /Span<>> BDC 1.33 0 Td ( )Tj EMC 0.511 0 Td [(\230)0.5(\r)0.5(\026)0.6(\027)0.5(\024)0.5(\r)]TJ /Span<>> BDC 3.117 0 Td ( )Tj EMC [(\222)0.5(.)0.5(\212)0.5(.)0.5(,)0.5( \222)0.5(\035)0.5(\017)0.5()0.6(\024)0.5(\r)0.5(\f)0.5(\022)0.5(\017)0.6(\005)]TJ /Span<>> BDC 8.146 0 Td ( )Tj EMC [(\206)0.5(.)0.5(\200)0.5(.)0.5(,)0.5( \231)0.5(\017)0.5(\022)0.5(\031)0.6(\027)0.5(\024)0.5(\r)0.5(\026)]TJ /Span<>> BDC 7.434 0 Td ( )Tj EMC [(\242)0.5(.)0.5(\200)0.5(.)0.5(,)0.6( \017)]TJ /Span<>> BDC 3.821 0 Td ( )Tj EMC [(\f)0.5(\024)0.5(\026)0.5(\r)0.5(\021)0.5(.)12( )]TJ 0 Tc 0.111 Tw -24.361 -1.25 Td (\233\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \n\024\007\ \036\035\017\030\024\r\026\027\017\036 \022\024\n\023\030\036\f\f\017\024\ \027\027\024\020\024 \026\027\026\f\021\024\n\024\026 )Tj -0.043 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC [(\007\r\031\f\021\r\024\035\034\027\024\005 \220\027\021\036\030\024\f\021\ \024\n\036 )0.5(\f)]TJ /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n )0.5(\031\f\021\030\024\005\f\021\r\026 \017)]TJ /Span<>> BDC ( )Tj EMC 25.329 0 Td (\027\017\022\036)Tj 0 Tw (-)Tj -0.01 Tw -25.329 -1.25 Td (\035\017\007\026 \021\017\021\026\027\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\026\n\016\021\034\033 \235\024\030\n\t. )Tj /T1_3 1 Tf (\211\027\024\023\025\022\n \204\n\024\033\027\032\022\026\027\025\023\020\ \f\017\025\031\235 \022)Tj /Span<>> BDC ( )Tj EMC (\n\f\022)Tj 0 Tw (-)Tj 0.196 Tw T* [(\025\022\007\027\024\n\031\235 )0.6(\200\022\032\r\032\b\022\022)]TJ /T1_0 1 Tf [(. )0.5(2022;15\(1\):46\22657. )0.5(d)-15.9(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw 18.714 0 Td (10.18499/2070-478X-)Tj -18.714 -1.25 Td (2022-15-1-46-57)Tj 0 0 0 1 k /GS1 gs 0.005 Tw [( / Iv)-14.9(anov)]TJ /Span<>> BDC ( )Tj EMC [(S.D., S)-16(l)-31(izovsk)-15.9(i\031)]TJ /Span<>> BDC ( )Tj EMC [(G.V., S)-16(hikunov)-14.9(a)]TJ /Span<>> BDC ( )Tj EMC [(Y.V., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC (al. )Tj 0.064 Tw T* [(E)35(xper)-37(iment)15.1(al simul)-15.9(a)15(t)-32(ion of)]TJ /Span<>> BDC ( )Tj EMC [(com)10(p)25(r)-24(ession anast)17(omosis in d)-16(ouble-bar)]TJ 0 Tw 27.286 0 Td (-)Tj 0.049 Tw -27.286 -1.25 Td [(r)-24(eled enter)-32(ost)17(omy using a)]TJ /Span<>> BDC ( )Tj EMC [(t)-32(i)-23.9(t)15(anium nick)10(el)-30.9(ide memor)-23.9(y shape dev)-16(ice. )]TJ /T1_3 1 Tf 0.115 Tw T* [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(e)-15(xper)-37(imental and clinical surg)12(er)-43(y.)]TJ /T1_0 1 Tf ( 2022;15\(1\):46\22657. \(in )Tj 0.023 Tw T* [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.18499/2070-478X-2022-15-1-46-57)Tj 0 0 0 1 k /GS1 gs 0.052 Tw T* (14.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(W)22(eber)]TJ /Span<>> BDC ( )Tj EMC (MC, Clees)Tj /Span<>> BDC ( )Tj EMC (Z, Buck)Tj /Span<>> BDC ( )Tj EMC [(A, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. R)11(ole of)]TJ /Span<>> BDC ( )Tj EMC [(t)-13(he ser)-31.9(osa in intest)-32(inal )]TJ 0.239 Tw -1.796 -1.25 Td [(anast)17(omo)17(t)-32(ic heal)-31(ing: insights fr)-32(om in-dept)-13(h hist)17.1(ol)30(o)-16(gical anal)35(y)-12.9(sis )]TJ 0.007 Tc 0.35 Tw T* (of)Tj /Span<>> BDC ( )Tj EMC [(human )0.5(and mur)-37.1(ine anast)16.9(omoses. )]TJ /T1_3 1 Tf 16.47 0 Td (BJS Open)Tj /T1_0 1 Tf [(. 2024;8\(5\):108.)7( )]TJ 0 Tc 0 Tw -16.47 -1.25 Td [(d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 1.847 0 Td [(10.1093/bjsopen/zr)-32.9(ae108)]TJ 0 0 0 1 k /GS1 gs 0.157 Tw -1.847 -1.25 Td (15.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Al)30(ver)-23.9(d)17(y)]TJ /Span<>> BDC ( )Tj EMC [(JC, S)-24(char)-24(de)-10.9(y)]TJ /Span<>> BDC ( )Tj EMC [(HM. Anast)17(omo)17(t)-32(ic leak: t)17(o)-14(w)-12(ar)-23.9(d an)]TJ /Span<>> BDC ( )Tj EMC (under)Tj 0 Tw 25.49 0 Td (-)Tj 0.312 Tw -27.286 -1.25 Td [(st)15(anding of)]TJ /Span<>> BDC ( )Tj EMC [(i)-23.9(ts r)-32(o)-16(o)17(t causes. )]TJ /T1_3 1 Tf [(Jour)-13.9(nal of)]TJ /Span<>> BDC ( )Tj EMC [(Gastrointestinal Surg)12(er)-42.9(y)]TJ /T1_0 1 Tf 0 Tw (. )Tj 0.023 Tw T* [(2021;11\(25\):2966\2262975. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.1007/s11605-021-05048-4)Tj 0 0 0 1 k /GS1 gs 0.135 Tw T* (16.)Tj /Span<>> BDC ( )Tj EMC 1.796 0 Td [(Ok)-17(afor)]TJ /Span<>> BDC ( )Tj EMC [(DK, K)-16(a)15(t)-10(y)22(al)]TJ /Span<>> BDC ( )Tj EMC [(G, K)-16(aur)]TJ /Span<>> BDC ( )Tj EMC [(G, e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. S)-16(ingle-l)-15.9(a)15(yer or d)-15.9(ouble-l)-16(a)15(yer )]TJ -0.05 Tw -1.796 -1.25 Td [(intest)-31.9(inal anast)17(omosis: A)]TJ /Span<>> BDC ( )Tj EMC [(sy)-13(stema)15.1(t)-32(ic r)-24(ev)-15.9(iew of)]TJ /Span<>> BDC ( )Tj EMC [(r)-33(and)-16(omized contr)-31.9(olled )]TJ 0 Tw T* [(tr)-37(ials. )]TJ /T1_3 1 Tf 2.646 0 Td (Cureus)Tj /T1_0 1 Tf 0.023 Tw [(. 2023;15\(10\):e46697. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw [(10.7759/cur)-23.9(eus.46697)]TJ /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.165 56.0378 Tm (70)Tj ET endstream endobj 1271 0 obj <>/Border[0 0 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[(Ef)-31(fectiv)12.1(eness of ne)11(w polymer membr)21.1(anes for intestinal anastomoses)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.134 Tw 10 0 0 10 42.5197 578.6938 Tm (\r\024\007\031\b\026 \r)Tj /Span<>> BDC ( )Tj EMC (\032\017\007\022\024\f\021\017\) \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\036\027\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (2\2263)Tj /Span<>> BDC ( )Tj EMC (\030\026\026 \023\030\036)Tj 0 Tw (-)Tj 0.232 Tw 0 -1.218 TD [(\r\t\001\026\033\013\036\n )0.5(\027\024\030\n\026\035\034\027\024\036 )0.6(\235\017\017\024\035\024\020\017\004\036\f\022\024\036 )0.6(\007\026\r\035\036\027\017\036 )]TJ 0.024 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\r\036\021\036 \240\025\221 \(20\22630 \n\n \030\021.\f\021\ .\). \221\026\022\032\036 \f\021\024\017\021 \024\021\n\036)Tj 0 Tw (-)Tj 0.094 Tw 0 -1.218 TD [(\021\017\021\034, )0.5(\004\021\024 )0.5(\023\030\017)]TJ /Span<>> BDC ( )Tj EMC 5.753 0 Td [(\017\f\023\024\035\034\024\r\026\027\017\017 )0.6(\030\026\030\026\002\024\021\026\027\027\t\b )0.6(\026\r\021\024\030\026)]TJ 0 Tw (-)Tj 0.026 Tw -5.753 -1.218 Td (\n\017 \215\204 \(\020\030\031\023\023\t \2231\2265\) \024\021\n\036\004\ \026\033\021\f\016 \r\t\f\024\022\017\036 \027\026\004\036\027\017\016 \ )Tj 0.326 Tw 0 -1.218 TD (\007\026\r\035\036\027\017\016, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\022\024\021\024\030\024\n \r\017\031\026\035\034\027\024 \030\036\020\017\ \f\021\030\017\030\024\r\026\035\017 )Tj 0.289 Tw 0 -1.218 TD (\023\030\017\027\026\022\017 \027\026\030\031\001\036\027\017\016 \020\036\ \030\n\036\021\017\004\027\024\f\021\017 \025\202. \200\036\030\024\016\021\ \027\024, )Tj 0.025 Tw 0 -1.218 TD (\220\021\024 \024\002\031\f\035\024\r\035\036\027\024 \023\035\024\021\027\ \024\005 \235\017\022\f\026\006\017\036\005 \215\204 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \001\r\024\r )Tj 0.23 Tw 0 -1.218 TD (\026)Tj /Span<>> BDC ( )Tj EMC 1.352 0 Td [(\f\004\036\021 )0.5(\017\b )0.6(\r\t\f\024\022\017\b )0.5(\026\007\020\036\017\r\027\t\b )0.5(\f\r\024\005\f\021\r. )0.6(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 18.863 0 Td (\220\021\024\n )Tj 0.135 Tw -20.215 -1.218 Td (\027\026)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\021\016\032\036\027\017\017 \017\f\f\035\036\007\024\r\026\027\ \017\016 \(\023\024\020\030\031\032\036\027\017\016 \025\202 \f)Tj /Span<>> BDC ( )Tj EMC (\215\204 )Tj 0.128 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\031\) \027\036 \024\021\n\036\004\026\035\024\f\034 \027\026\030\ \031\001\036\027\017\016 \f\024\023\030\017\022\024\f\027\024\r\036\027\017\ \016 )Tj 0.243 Tw T* (\023\024\r\036\030\b\027\024\f\021\017 \215\204 \017)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 \f\021\036\027\022\017, \r)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\017\036 \024\021 )Tj 0.058 Tw T* (\n\036\n\002\030\026\027 \020\030\031\023\023\t \223 6, \235\017\022\f\026\ \006\017\016 \022\024\021\024\030\t\b \022)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 )Tj 0.188 Tw T* [(\f\021\036\027\022\036 \002\t\035\026 \n\017\027\017\n\026\035\034\027\024\ \005 )0.5(\r\r\017\007\031 \f\035\026\002\024\r\t\030\026\032\036\027\027\t\b )]TJ 0.027 Tw T* (\026\007\020\036\017\r\027\t\b \f\r\024\005\f\021\r, \004\021\024 \027\ \026\004\017\021\036\035\034\027\024 \026\021\030\031\007\027\016\035\024\ \b\024\007 )Tj 0 Tw T* (\220\022\f\023\036\030\017\n\036\027\021\026.)Tj 0.091 Tw T* (\215\030\017 \030\026\027\032\017\030\024\r\026\027\017\017 \020\030\031\ \023\023 \017\f\f\035\036\007\024\r\026\027\017\016 \024\021 \027\026\017\ \002\024\035\034)Tj 0 Tw (-)Tj 0.209 Tw T* [(\001\036\020\024 )0.5(\027\026\004\036\027\017\016 )0.6(\007\026\r\035\036\027\017\016 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC 11.948 0 Td [(\027\026\017\n\036\027\034\001\036\n\031, )0.6(\023\024\035\031\004\017\035\017 )]TJ 0.051 Tw -11.948 -1.218 Td [(\f\035\036\007\031\033\013\017\005 )0.5(\030\016\007: \223 )0.5(8 > \223 1 > )0.5(\223 4 > \223 )0.5(5 > \223 2 > \223 )0.5(3 )]TJ 0.099 Tw T* (> \223 7, \223 6. \215\030\017\n\036\004\026\021\036\035\034\027\024, \004\ \021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \2236 \017)Tj /Span<>> BDC ( )Tj EMC (\2237 )Tj 0.194 Tw T* (\027\026\017\n\036\027\034\001\017\036 \027\026\004\036\027\017\016, \022\ \024\021\024\030\t\036 \023\030\026\022\021\017\004\036\f\022\017 \027\036\ \024\021)Tj 0 Tw (-)Tj 0.349 Tw T* (\035\017\004\026\033\021\f\016. \233\021\024 \022\024\f\r\036\027\027\024\ \023\024\r\024\035\016\036\021 \f\031\007\017\021\034 \024)Tj /Span<>> BDC ( )Tj EMC (\027\017)Tj 0 Tw (-)Tj 0.221 Tw T* (\022\024\005 \220\235\235\036\022\021\017\r\027\024\f\021\017 \017\007\036\ \035\017\016 \007\035\016 \007\026\027\027\024\020\024 \r\026\030\017\026\ \027\021\026 )Tj 0 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\016.)Tj 0.01 Tc 0.175 Tw T* (\200\t\f\024\022\017\036 \027\026\004\036\027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \2238 \f)Tj /Span<>> BDC ( )Tj EMC [(\017\f\023\024\035\034\024\r\026\027\017\036\n)9.9( )]TJ 0.118 Tw T* (\007\r\031\030\016\007\027\024\020\024 \001\r\026, \002\035\017\022\017\ \022)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\024\r\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \f)Tj /Span<>> BDC ( )Tj EMC (\017\f)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.263 Tw T* [(\023\024\035\034\024\r\026\027\017\036\n \030\026\030\026\002\024\021\026\ \027\027\t\b \026\r\021\024\030\026\n\017 \024\002\030\026\006\024\r.)10( )]TJ 0.23 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\220\021\024\n, \027\036\f\n\024\021\030\016 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (\001\017\030\024\022\024\036 \024\002\f\031\032\007\036\027\017\036 \f\030\ \036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.543 Tw T* [(\007\017 )0.5(\017\f\f\035\036\007\024\r\026\021\036\035\036\005 )0.5(\220\235\235\036\022\021\017\r\027\024\f\021\017 )0.5(\024\007\027\024\030\016\007\027\024\020\024)10( )]TJ 0.176 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC (\007\r\031\030\016\007\027\024\020\024 \001\r\024\r [13\22616], \r)Tj /Span<>> BDC ( )Tj EMC [(\f\035\031\004\026\036 )0.5(\017\f\023\024\035\034\024\r\026)]TJ 0 Tc 0 Tw (-)Tj 0.01 Tc 0.361 Tw T* (\027\017\016 \024\030\017\020\017\027\026\035\034\027\024\020\024 \n\036\ \021\024\007\026 \023\027\036\r\n\024\023\030\036\f\f\017\017 \r)Tj /Span<>> BDC ( )Tj EMC (\022\026)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.23 Tw T* [(\004\036\f\021\r\036 \f\023\024\f\024\002\026 \024\006\036\027\022\017 \020\ \036\030\n\036\021\017\004\027\024\f\021\017 \026\027\026\f\021\024\n\024\ \026)10( )]TJ 0.127 Tw T* (\026)Tj /Span<>> BDC ( )Tj EMC [(\f\004\036\021 \031\021\036\004\022\017 \r\024\007\031\b\026, \023\030\036\ \007\023\024\004\021\036\027\017\036 \f\021\024\017\021 \024\021\007\026\ \021\034)10( )]TJ 0.056 Tw T* [(\007\r\031\030\016\007\027\024\n\031 \001\r\031. \221\026\022\032\036 \253\ \026\n\036\027\017\021\034\273 \007\r\031\030\016\007\027\t\005 \001\024\ \r)10( )]TJ 0.286 Tw 0 -1.218 TD (\017)Tj /Span<>> BDC ( )Tj EMC (\031\n\036\027\034\001\017\021\034 \r\030\036\n\016 \024\023\036\030\026\ \006\017\017 \023\024\r\024\035\017\021 \023\030\017\n\036\027\036)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.223 Tw 0 -1.218 TD (\027\017\036 \030\026\030\026\002\024\021\026\027\027\t\b \215\204, \022\ \024\021\024\030\t\036 \023\024\n\017\n\024 \026\007\020\036\017\r)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.313 Tw 0 -1.218 TD [(\027\t\b )0.5(\f\r\024\005\f\021\r )0.5(\024\002\035\026\007\026\033\021 )0.5(\036\013\036 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC 13.874 0 Td [(\026\027\021\017\002\026\022\021\036\030\017\026\035\034\027\024\005)10( )]TJ 0.101 Tw -13.874 -1.218 Td (\026\022\021\017\r\027\024\f\021\034\033, \004\021\024 \023\024\r\024\035\ \017\021 \017\f\023\024\035\034\024\r\026\021\034 \017\b \017)Tj /Span<>> BDC ( )Tj EMC (\r \031\f)Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.184 Tw 0 -1.218 TD (\035\024\r\017\016\b \023\036\030\017\021\024\027\017\021\026. \003\026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \220\035\026\f\021\017\004\027\024\f\021\017 \215\204 \r\024\ )Tj 0 Tc 0 Tw (-)Tj 0.01 Tc 0.019 Tw 0 -1.218 TD (\n\024\032\027\024 \030\026\f\f\n\024\021\030\036\021\034 \r\026\030\017\ \026\027\021\t \017\b \027\026\035\024\032\036\027\017\016 \027\026)Tj /Span<>> BDC ( )Tj EMC [(\024\027\031)10( )]TJ 0.345 Tw 0 -1.218 TD (\025\202 \r)Tj /Span<>> BDC ( )Tj EMC [(\b\024\007\036 \220\027\007\024\r\017\007\036\024\b\017\030\031\030\020\017\ \004\036\f\022\017\b \024\023\036\030\026\021\017\r\027\t\b)10( )]TJ -0.01 Tw 0 -1.218 TD (\r\n\036\001\026\021\036\035\034\f\021\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 14 0 0 14 275.0305 578.6938 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.203 Tw 10 0 0 10 274.9606 554.3378 Tm (\203\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 \025\202 \ \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 \016\r\035\016\036\021\ \f\016 )Tj 0.544 Tw 0 -1.218 TD (\026\022\021\031\026\035\034\027\024\005 \023\030\024\002\035\036\n\024\005\ \026\002\007\024\n\017\027\026\035\034\027\024\005 \b\017\030\031\030\020\ \017\017. )Tj 0.28 Tw T* [(\217\036\031\035\034\021\026\021\t )0.6(\023\030\024\r\036\007\036\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024\r\024\035\016\033\021 )]TJ 0.066 Tw T* (\031\021\r\036\030\032\007\026\021\034, \004\021\024 \n\036\b\026\027\017\ \004\036\f\022\024\036 \031\022\030\t\021\017\036 \024\027\t \025\202 \030\ \026)Tj 0 Tw (-)Tj 0.407 Tw T* [(\030\026\002\024\021\026\027\027\t\n\017 \024\002\030\026\006\026\n\017\ )0.5(\215\204 \016\r\035\016\036\021\f\016 )0.5(\007\024\f\021\026\021\024\004\027\024 )]TJ 0.124 Tw T* (\220\235\235\036\022\021\017\r\027\t\n \n\036\021\024\007\024\n \023\030\ \024\235\017\035\026\022\021\017\022\017 \027\036\f\024\f\021\024\016\021\ \036\035\034)Tj 0 Tw (-)Tj 0.045 Tw T* (\027\024\f\021\017 \025\202. \233\021\024 \023\024\r\024\035\016\036\021\ \030\036\022\024\n\036\027\007\024\r\026\021\034 \017\b \007\035\016 \007\ \026\035\034)Tj 0 Tw (-)Tj T* (\027\036\005\001\036\020\024 \021\036\f\021\017\030\024\r\026\027\017\016\ .)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.133 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-5.9(\017)2.7()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.8(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.8(:)]TJ /T1_4 1 Tf [( \035)14.6(\020)0.7(\016)5.1(\020)1.8(\032\027)2.3(\025)10.7(\n)9.8(\031)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)7.3(\003)-2.3(.)7.8(, )]TJ -0.007 Tc 0.007 Tw T* [(\035)7.6(\022)0.7(\033\020)-5.2(\023)-3(\031)2.6(\021)]TJ /Span<>> BDC 3.694 0 Td ( )Tj EMC [(\211)17.3(.\003)-9.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -3.694 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.3(\026)-6.4(\002)-9.9(\024)-10.8(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.5(\024)-4.3(\r)10.4(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw [( \205)1.9(\027\021)-7.8(\027)-7.9(\032)-0.6(\022\025)-3.2(\031)2.6(\021)]TJ /Span<>> BDC 17.148 0 Td ( )Tj EMC [(\220)-5.6(.\003)-9.3(.)]TJ /T1_1 1 Tf 0.018 Tc -0.018 Tw -17.148 -1.218 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.7(:)]TJ /T1_4 1 Tf -0.029 Tc 0.029 Tw 11.349 0 Td [( \202)6.3(\r)-21.9(\030)-26.3(\032)-18.3(\t)-14.4(\021)-23.5(\006)-26.3(\027)-22.4(\021)-26.9(\020)]TJ /Span<>> BDC 4.945 0 Td ( )Tj EMC [()36(.\001.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -16.294 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.007 Tc 0.007 Tw 7.694 0 Td [( \205)1.8(\027\021)-7.8(\027)-7.9(\032)-0.6(\022\025)-3.2(\031)2.6(\021)]TJ /Span<>> BDC 4.408 0 Td ( )Tj EMC [(\220)-5.6(.\003)-9.3(.)0.8(,)-7( \202)8.6(\031)-4.6(\026\020)-5.2(\032)-6.9(\031)2.6(\021)]TJ /Span<>> BDC 5.853 0 Td ( )Tj EMC [(\220)-5.6(.\003)-9.3(.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -17.955 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf [( \035)14.6(\020)0.6(\016)5.1(\020)1.8(\032\027)2.3(\025)10.7(\n)9.8(\031)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)7.3(\003)-2.3(.)7.8(, \035)14.6(\022)7.8(\033)7.4(\020)1.8(\023)4(\031)9.6(\021)]TJ /Span<>> BDC ( )Tj EMC [(\211)24.3(.)7.3(\003)-2.3(.)]TJ /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.098 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.5(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e )0.5(s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( V)-5.5(i)2.6(c)-28.6(t)1.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-4.5(a)-4.5(z)12.9(ar)2.4(e)-2.6(n)7.5(k)12.9(o)-3.7(, )]TJ -0.006 Tc 0.006 Tw T* [(V)-11.5(ia)-11(c)-4.1(h)-4.1(e)-24(s)3.3(l)-2.7(a)-10.4(v)]TJ /Span<>> BDC 4.081 0 Td ( )Tj EMC [(A)-18.6(.)]TJ /Span<>> BDC 1.08 0 Td ( )Tj EMC [(L)-2.9(ip)-8(a)-10.9(t)-4.6(o)-6.6(v)]TJ /T1_1 1 Tf 0 Tc 1.014 Tw -5.16 -1.218 Td [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n )0.5(a)2.4(n)-4.6(d )0.6(p)-3.8(r)-6(o)-7(ce)-13.3(s)-12.8(s)-16.6(i)7.1(n)-1.9(g )0.6(o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC 15.798 0 Td [(t)-16.7(h)-5.3(e )0.6(m)1.8(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf 0 Tw ( )Tj -15.798 -1.218 Td [(D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(e)-4(v)6.6(e)-1.7(r)-35.2(i)8.4(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf -0.007 Tc 0.007 Tw T* [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( p)-10.8(r)-12.9(o)-14(c)-6.9(e)-20.2(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf -0.005 Tc 0.005 Tw 9.088 0 Td [( T)44.7(a)-9.9(t)-35(y)-1.2(a)-5.8(na)]TJ /Span<>> BDC 3.339 0 Td ( )Tj EMC [(N)8(.)]TJ /Span<>> BDC 1.088 0 Td ( )Tj EMC [(K)7.3(u)-6.6(dr)-45.2(y)-1.2(a)-9.4(v)-36.5(t)-34.1(se)-9(v)5.8(a)]TJ /T1_1 1 Tf 0 Tc 0.976 Tw -13.516 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20.1(:)]TJ /T1_4 1 Tf [( D)-2(m)5.8(i)0.9(t)-5.4(r)-35.3(iy)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(S)5.6(e)-4(v)6.6(e)-1.7(r)-35.3(i)8.4(n)1.9(o)-0.6(v)33.6(, )]TJ 0 Tw T* [(D)-2(m)5.8(i)0.9(t)-5.4(r)-40.2(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.5(.)]TJ /Span<>> BDC ( )Tj EMC [(K)13.3(om)4.3(ar)2.5(o)-0.6(v)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw T* [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( V)-5.5(i)2.6(c)-28.6(t)1.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)-4.6(a)-4.5(z)13(ar)2.4(e)-2.6(n)7.5(k)12.9(o)-3.7(, V)-5.5(i)6(a)-5(c)1.8(h)1.9(e)-18(s)9.3(l)3.3(a)-4.4(v)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(L)3.2(i)5.8(p)-2(a)-4.9(t)1.4(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.581 Tw T* (\214\026\026\030\036\027\022\024 \200\017\022\021\024\030 \202\027\026\021\ \024\035\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \007.\n.\027., \023\030\024)Tj 0 Tw (-)Tj 0.964 Tw T* [(\235\036\f\f\024\030, )0.5(\026\r\036\007\031\033\013\017\005 )0.5(\022\026\235\036\007\030\024\005 )0.6(\b\017\030\031\030\020\017\004\036\f\022\017\b )]TJ 0.653 Tw T* (\002\024\035\036\027\036\005 \230\027\f\021\017\021\031\021\026 \027\036\ \023\030\036\030\t\r\027\024\020\024 \024\002\030\026\024\r\026\027\017\ \016, )Tj 0.29 Tw T* [(\030\036\022\021\024\030 \205\206\207\210\211 )0.5(\200\210 \025\206\204\211 )0.5(\204\017\027\007\030\026\r\026 \217\024\f\f\017\017; )0.5(ORCID )]TJ 0 Tw T* (0000-0002-2069-7701.)Tj 0.03 Tc 0.702 Tw T* (\214\017\023\026\021\024\r \200\016\004\036\f\035\026\r \202\035\036\022\ \f\026\027\007\030\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC [(\227 \007.\n.\027.,)30( )]TJ 0.676 Tw T* [(\023\030\024\235\036\f\f\024\030, \023\030\024\235\036\f\f\024\030 \022\026\ \235\036\007\030\t \024\023\036\030\026\021\017\r\027\024\005)30( )]TJ 0.767 Tw T* (\b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\023\024\020\030\026\235\017\004\036\f\022\024\005 \026\027\026\021\ \024\n\017\017, \026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 1.138 Tw T* [(\r\036\007\031\033\013\017\005 \035\026\002\024\030\026\021\024\030\017\036\ \005 \220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\024\005)30( )]TJ 0.621 Tw T* [(\b\017\030\031\030\020\017\017 )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 6.372 0 Td [(\024\027\022\024\035\024\020\017\017 )0.5(\027\026\031\004\027\024-\017\f\f\035\036\007\024\r\026\021\036\035\034)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.432 Tw -6.372 -1.218 Td [(\f\022\024\020\024 \017\027\f\021\017\021\031\021\026 \220\022\f\023\036\ \030\017\n\036\027\021\026\035\034\027\024\005 \n\036\007\017\006\017\027\ \t,)30( )]TJ 0.109 Tw T* (\023\030\024\030\036\022\021\024\030 \023\024)Tj /Span<>> BDC ( )Tj EMC (\027\026\031\004\027\024\005 \030\026\002\024\021\036 \017)Tj /Span<>> BDC ( )Tj EMC [(\017\027\027\024\r\026\006\017\024\027\027\024\n\031)30( )]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tc 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 2.)Tj 0 0 0 1 k /GS1 gs /T1_4 1 Tf [( \206\027\016\r\f\017\023\020\023\013 \033\031\033\020\032\025\031\b\031\ \024\032\020\021\025\027\025\022\t \016\025\020\007\027\025\022\235 \030\ \020\021\f\027\025\022\t \021\031\016\030)0.5(\r\200\020 \033\032\022)]TJ /Span<>> BDC ( )Tj EMC (\033\025\027\021\026\031\033\032\027\024\024\022\022 \n\022\213\027\007\025\ \013\200 \020\025\020\024\023\031\026\031\016\031\021)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.027 Tc 0.027 Tw 0 -1.2 TD [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 2)-34.3(.)]TJ 0 0 0 1 k /GS1 gs /T1_4 1 Tf 0 Tc 0 Tw 3.334 0 Td [( R)2.8(e)-22(s)6.7(u)-1.5(l)5.3(t)-32.9(s o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(p)-6.3(a)-6.3(i)5(r)-33.4(w)-26.7(i)6.6(s)0.5(e c)2.8(o)-4(m)-0.9(p)-6.4(a)-4.1(r)-39(i)6.6(s)0.5(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(a)-6.2(i)4.9(r p)-2.8(r)-2(e)-22(s)-10.5(s)6.7(u)1.6(r)-2(e v)6.4(a)-4.5(lu)-3.2(e)-22(s d)0.8(u)1.7(r)-39(i)3.9(n)-0.6(g p)-3.7(n)-2.4(e)-4.2(u)0.6(m)-5.3(o)-5.3(p)-2.8(r)-2(e)-21.9(s)-10.5(s)-12.5(i)-1.4(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(i)4(n)-0.6(t)-1.6(e)-22(s)-14.8(t)-29.1(i)3.9(na)-4.5(l a)-5.1(n)0.5(a)-7.2(s)-14.8(t)-3(o)-4(m)-5.3(o)-1.1(s)0.5(e)-22(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 99.4626 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 156.1555 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 212.8484 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 269.5413 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 326.2343 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 382.9272 715.181 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 703.7117 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 703.7117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 692.2505 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 692.2505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 680.7892 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 680.7892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 669.3279 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 669.3279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 657.8666 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 657.8666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.4053 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 646.4053 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 646.4053 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 635.194 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 634.944 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 42.7697 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 99.4626 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 99.4626 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 156.1555 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 212.8484 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 269.5413 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 326.2343 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 382.9272 634.944 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 634.944 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 623.7328 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 623.4828 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 99.4626 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 156.1555 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 212.8484 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 269.5413 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 326.2343 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 382.9272 623.4828 cm 0 0 m 56.693 0 l S Q q 1 0 0 1 439.6201 623.4828 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 58.9604 706.5463 Tm (\027\006\210\212\212\004)Tj 7.838 0 Td (\2362)Tj 7.087 0 Td (\2363)Tj 7.087 0 Td (\2364)Tj 7.087 0 Td (\2365)Tj 7.087 0 Td (\2366)Tj 6.97 0 Td (\236 7)Tj 7.087 0 Td (\236 8)Tj /T1_1 1 Tf -51.91 -1.433 Td (\223 1)Tj 9.683 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 6.337 0 Td (0,001*)Tj 7.087 0 Td (0,003*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 2)Tj 16.77 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 6.337 0 Td (0,001*)Tj 7.087 0 Td (0,002*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 3)Tj 23.856 0 Td (1,0)Tj 7.087 0 Td (1,0)Tj 6.337 0 Td (0,024*)Tj 7.337 0 Td (0,054)Tj 7.587 0 Td (1,0)Tj -52.203 -1.433 Td (\223 4)Tj 30.943 0 Td (1,0)Tj 6.337 0 Td (0,001*)Tj 7.087 0 Td (0,003*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 5)Tj 37.28 0 Td (0,002*)Tj 7.087 0 Td (0,005*)Tj 7.837 0 Td (1,0)Tj -52.203 -1.433 Td (\223 6)Tj 45.116 0 Td (1,0)Tj 6.337 0 Td (0,002*)Tj -51.453 -1.433 Td (\223 7)Tj 51.453 0 Td (0,004*)Tj /T1_4 1 Tf 7 0 0 7 42.5197 611.998 Tm [(\004\032\022\026\027\007\020\025\022\027: \207\025\020\n\031\026 \253*\273\ \031\023)16.3(\026\027\007\027\025\013 \024\023\020)49(\023\022\024\023\022\007\027\024\n\022 \016\025\020\007\022\026\013\027 \ \016\025\020\007\027\025\022\t \(\033\032\022 p)]TJ /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8518 56.0378 Tm (69)Tj ET endstream endobj 1262 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 10 0 0 10 70.8661 724.8299 Tm (\()Tj /T1_1 1 Tf (n)Tj /T1_0 1 Tf 0.182 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (30\) \r)Tj /Span<>> BDC ( )Tj EMC (\220\022\f\023\036\030\017\n\036\027\021\026\035\034\027\t\b \020\030\031\ \023\023\026\b \017)Tj /Span<>> BDC ( )Tj EMC (\024\021\035\017\004\027\t\n )Tj 0.124 Tw 0 -1.218 TD (\024\021 \027\024\030\n\026\035\034\027\024\020\024 \030\026\f\023\030\036\ \007\036\035\036\027\017\036\n \r\t\002\024\030\022\017 \023\024)Tj /Span<>> BDC ( )Tj EMC (\022\030\017\021\036)Tj 0 Tw (-)Tj 0.032 Tw T* (\030\017\033 \231\026\023\017\030\024\226\211\017\035\022\026 \f\030\026\ \r\027\036\027\017\036 \027\036\f\022\024\035\034\022\017\b \020\030\031\ \023\023 \007\035\016 )Tj -0.012 Tw T* (\024\006\036\027\022\017 \f\021\026\021\017\f\021\017\004\036\f\022\017 \ \027\026\004\017\n\t\b \030\026\035\017\004\017\005 \023\030\024\r\024\ \007\017\035\017 )Tj 0.28 Tw T* (\f)Tj /Span<>> BDC ( )Tj EMC (\017\f\023\024\035\034\024\r\026\027\017\036\n \027\036\023\026\030\026\ \n\036\021\030\017\004\036\f\022\024\020\024 H-\022\030\017\021\036\030\017\ \016 )Tj 0.797 Tw T* [(\025\030\026\f\022\036\035\026\226\211\024\035\035\017\f\026. )0.6(\215\024\023\026\030\027\t\036 )0.5(\f\030\026\r\027\036\027\017\016 )0.6(\(post-)]TJ 0.165 Tw 0 -1.218 TD [(ho)-16(c \f\030\026\r\027\036\027\017\016\), \r\t\023\024\035\027\036\027\t \f)]TJ /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 U-\022\030\017\021\036\030\017\016 )Tj 0.681 Tw 0 -1.218 TD [(\204\026\027\027\026\226\211\017\021\027\017. )0.6(\025\030\017\021\017\004\036\f\022\017\005 )0.6(\031\030\024\r\036\027\034 )0.5(\027\026\004\017\n\024\f\021\017 )]TJ 0.169 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\r\036\030\022\036 \f\021\026\021\017\f\021\017\004\036\f\022\ \017\b \020\017\023\024\021\036 \r)Tj /Span<>> BDC ( )Tj EMC (\007\026\027\027\024\n \017\f)Tj 0 Tw (-)Tj T* (\f\035\036\007\024\r\026\027\017\017 \023\030\017\027\017\n\026\035\017 \ \030\026\r\027\t\n 0,05.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 578.6938 Tm [(\033\034\020)21(\224)50(\r\237)46(\024)52(\026)45(\024\233)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.131 Tw 10 0 0 10 70.8661 554.3378 Tm (\222\024\020\035\026\f\027\024 \023\024\035\031\004\036\027\027\t\n \r)Tj /Span<>> BDC ( )Tj EMC (\b\024\007\036 \017\f\f\035\036\007\024\r\026\027\017\016 \007\026\027\027\ \t\n, )Tj 0.445 Tw T* (\017\n\036\033\021\f\016 \f\021\026\021\017\f\021\017\004\036\f\022\017 \ \027\026\004\017\n\t\036 \024\021\035\017\004\017\016 \n\036\032\007\031\ )Tj -0.006 Tw T* (\020\030\031\023\023\026\n\017 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf -0.006 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,00002\). \203\026\017\002\024\035\034\001\036\036 \027\026\004\036\027\ \017\036 \007\026\r\035\036)Tj 0 Tw (-)Tj -0.028 Tw T* (\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\027\036\r\n\024\023\030\036\f\f\017\017 \f\235\024\030\n\017\030\024\ \r\026\027\027\t\b \025\202 \r\t\016\r\035\036)Tj 0 Tw (-)Tj -0.005 Tw T* (\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \2238 \(\007\r\031\030\016\007\027\t\005 \025\202\ \) \(85 [79,5; 87]\), \f)Tj /Span<>> BDC ( )Tj EMC (\030\026)Tj 0 Tw (-)Tj -0.051 Tw T* (\027\017\006\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (0,5 \n\n \030\021.\f\021. \024\021\n\036\004\036\027\t \027\026\004\036\ \027\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \2231 )Tj 0.063 Tw T* (\(\215\204 \002\036 \r\027\036\f\036\027\017\016 \026\027\021\017\002\026\ \022\021\036\030\017\026\035\034\027\t\b \f\030\036\007\f\021\r\) \(84,5\ )Tj 0.24 Tw T* ([83; 85]\) \017)Tj /Span<>> BDC ( )Tj EMC (\2234 \(\215\204 \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\f\036\027\017\036\n \214\036\r\024\235\035\024\022\f\026\006\017\ \027\026 )Tj 0.185 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\005 \215\200\215 \017)Tj /Span<>> BDC ( )Tj EMC (\247\024\020\036\022\f\024\035\026 \r)Tj /Span<>> BDC ( )Tj EMC (\f\035\024\005 \202\035\034\020\017\027\026\021\026 \027\026\021\030\017\ \016\) )Tj 0.133 Tw T* (\(84,5 [83,25; 86]\) \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (2\). \203\024 \027\026\004\036\027\017\016 \020\030\031\023\023\t \2238\ )Tj 0.602 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \023\ \030\036\024\002\035\026\007\026\036\021 \021\024\035\034\022\024 \027\026\ \007 )Tj 0.181 Tw 23.244 29.227 Td (\027\026\004\036\027\017\016\n\017 \020\030\031\023\023 \223 6 \(62 [60\ ,5; 63]\) \017)Tj /Span<>> BDC ( )Tj EMC (\223 7 \(63,5 )Tj 0.075 Tw 0 -1.218 TD ([59,5; 65,75]\) \027\026)Tj /Span<>> BDC ( )Tj EMC (23 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\) \017)Tj /Span<>> BDC ( )Tj EMC (21,5 \()Tj /T1_1 1 Tf 0 Tw (\032)Tj /T1_0 1 Tf 0.075 Tw /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\) \n\n )Tj 0 Tw 0 -1.218 TD (\030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021., \f\024\024\021\r\036\021\f\021\r\036\027\027\024 \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (2\).)Tj 0.268 Tw 0 -1.218 TD (\215\030\017 \f\030\026\r\027\036\027\017\017 \007\026\027\027\t\b \024\002\ \027\026\030\031\032\036\027\t \f\021\026\021\017\f\021\017\004\036\f\022\ \017 )Tj 0.006 Tw 0 -1.218 TD (\027\026\004\017\n\t\036 \024\021\035\017\004\017\016 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b \(\221\026\002\035.)Tj /Span<>> BDC ( )Tj EMC (2\): \027\026\004\036\027\017\016 \007\026\r)Tj 0 Tw (-)Tj -0.032 Tw 0 -1.218 TD (\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\027\036\r\n\024\023\030\036\f\f\017\017 \025\202 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \223 6 \(\n\036\n\002\030\026\027\026 )Tj 0.001 Tw 0 -1.218 TD (\017\023\035\026\027\021\017\030\031\036\n\026\016\) \(62 [60,5; 63]\) \n\ \036\027\034\001\036 \027\026)Tj /Span<>> BDC ( )Tj EMC (22,5 \n\n \030\021. )Tj -0.029 Tw 0 -1.218 TD (\f\021., \004\036\n \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \223 1 \(84,5 [83;85]\) \017)Tj /Span<>> BDC ( )Tj EMC (\223 4 \(84,5 [83,25; )Tj 0.027 Tw T* (86]\), \027\026)Tj /Span<>> BDC ( )Tj EMC (22)Tj /Span<>> BDC ( )Tj EMC (\227 \020\030\031\023\023\t \223 5 \(84 [82; 86,75]\), \027\026)Tj /Span<>> BDC ( )Tj EMC (21,5)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.078 Tw T* (\020\030\031\023\023\t \223 2 \(83,5 [83; 86,75]\), \027\026)Tj /Span<>> BDC ( )Tj EMC (21)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \2233 )Tj 0 Tw T* (\(83 [81,25; 85,25]\).)Tj 0.091 Tw T* (\200 \020\030\031\023\023\036 \2237 \(\017\f\023\024\035\034\024\r\026\027\ \017\036 \024\007\027\024\030\016\007\027\024\020\024 \025\202\) \(63,5 \ )Tj 0.472 Tw T* ([59,5; 65,75]\) \027\026\004\036\027\017\016 \024\006\036\027\017\r\026\ \036\n\024\020\024 \023\026\030\026\n\036\021\030\026 )Tj 0.182 Tw T* (\f\021\026\021\017\f\021\017\004\036\f\022\017 \027\026\004\017\n\024 \n\ \036\027\034\001\036 \027\026\004\036\027\017\005 \r)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026\b )Tj 0.066 Tw T* (\2231 \(84,5 [83; 85]\) \017)Tj /Span<>> BDC ( )Tj EMC (\2234 \(84,5 [83,25; 86]\) \(\027\026 21 \n\n )Tj 0.023 Tw T* (\030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021.\), \2232 \(83,5 [83; 86,75]\) \(\027\026 20 \n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021.\), \017)Tj /Span<>> BDC ( )Tj EMC (\2235 )Tj 0 Tw T* (\(84 [82; 86,75]\) \(\027\026 20,5 \n\n \030\021.)Tj /Span<>> BDC ( )Tj EMC (\f\021.\).)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 303.3769 493.4478 Tm [(\037\036)10(\032\224\222\230\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0 Tc 0.254 Tw 10 0 0 10 303.3071 469.0918 Tm (\215\030\017 \026\027\026\035\017\036 \007\026\027\027\t\b \023\027\036\ \r\n\024\023\030\036\f\f\017\017 \025\202 \r\t\016\r\035\036\027\024, )Tj 0.27 Tw T* (\004\021\024 \r\024 \r\f\036\b \020\030\031\023\023\026\b \017\f\f\035\036\ \007\024\r\026\027\017\016, \027\036\026\r\017\f\017\n\024 \024\021 )Tj 0.201 Tw T* (\n\036\021\024\007\017\022\017 \027\026\035\024\032\036\027\017\016 \025\ \202 \017)Tj /Span<>> BDC ( )Tj EMC (\022\024\035\017\004\036\f\021\r\026 \030\016\007\024\r \001\r\024\r, )Tj 0.47 Tw T* [(\020\036\030\n\036\021\017\004\027\024\f\021\034 )0.6(\027\026\030\031\001\026\035\026\f\034 )0.6(\(\023\024\016\r\035\036\027\017\036 )0.5(\023\031\t\030\034\022\024\r )]TJ ET q 70.866 306.667 113.386 111.439 re W n q /GS0 gs 113.385838 0 0 111.4640488 70.8661352 306.6414348 cm /Im0 Do Q Q q 184.252 306.667 113.386 108.409 re W n q /GS0 gs 113.385838 0 0 108.5813585 184.2519593 306.4946953 cm /Im1 Do Q Q q 297.638 306.667 113.386 110.356 re W n q /GS0 gs 113.385838 0 0 110.5031414 297.6377756 306.5204051 cm /Im2 Do Q Q q 411.024 306.667 113.386 111.439 re W n q /GS0 gs 113.385838 0 0 111.4640488 411.0236225 306.6414348 cm /Im3 Do Q Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.025 Tw 9 0 0 9 70.8661 295.8671 Tm [(\022\t\217\210\b\002\220 )0.5(1.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( )0.5(\205\200\027\026\020 )0.5(\021\013\033\031\f\025\027\025\022\t )0.5(\031\033\027\032\020\023\022\021\025\013\200 )0.6(\021\026\027\213\020\023\027\f\017\024\023\021 )0.6(\024)]TJ /Span<>> BDC ( )Tj EMC 25.929 0 Td [(\022\024\033\031\f\017\016\031\021\020\025\022\027\026 )0.5(\031\240\032\020\016\006\031\021 \004\215: )0.5(\003)]TJ /Span<>> BDC ( )Tj EMC 13.499 0 Td [(\227 \r\007\020\024\023\031\n )0.5(\023\031\025\n\031\235 )0.5(\n\022\213\n\022 )]TJ 0.014 Tw -39.428 -1.2 Td [(\033\031\030\b\031\023\031\021\f\027\025 )0.5(\030\f\t \026\031\030\027\f\022\032\031\021\020\025\022\t )0.6(\023\032\020\021\026\013 )0.5(\022)]TJ /Span<>> BDC ( )Tj EMC [(\025\020\f\031\255\027\025\022\t )0.6(\004\215; \221)]TJ /Span<>> BDC ( )Tj EMC 25.612 0 Td [(\227 \021\013\033\031\f\025\027\025\031 )0.5(\026\031\030\027\f\022\032\031\021\020\025\022\027 \023\032\020\021\026\013\ \r\007\020\024\023\n\020 \n\022\213\n\022; )0.5(\211)]TJ /Span<>> BDC ( )Tj EMC 23.782 0 Td (\227 )Tj 0 Tw -49.394 -1.2 Td (\025\020\f\031\255\027\025 \031\030\025\031\032\t\030\025\013\235 \020\025\ \020\024\023\031\026\031\016; \216)Tj /Span<>> BDC ( )Tj EMC (\227 \020\025\020\024\023\031\026\031\016 \r\n\032\013\023 \004\215)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.006 Tw 0 -1.2 TD [(F)-16(igure 1)47(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( The)Tj /Span<>> BDC ( )Tj EMC [(scheme for per)-34(for)-13.9(ming surgical inter)-41.9(v)12.9(entions using PM sam)16(ples: A)]TJ /Span<>> BDC ( )Tj EMC (\227 a)Tj /Span<>> BDC ( )Tj EMC (section of)Tj /Span<>> BDC ( )Tj EMC [(the intestine is p)46(repared to)]TJ /Span<>> BDC ( )Tj EMC (simu)Tj 0 Tw (-)Tj 0.01 Tw T* [(late injur)-42.9(y and ov)13(erlap PM; )0.5(\221)]TJ /Span<>> BDC ( )Tj EMC [(\227 simulation )0.5(of)]TJ /Span<>> BDC ( )Tj EMC [(intestinal )0.5(tube site injur)-43(y )0.5(w)13(as per)-34(for)-14(med; B)]TJ /Span<>> BDC ( )Tj EMC [(\227 sing)13(le-row anastomosis; \216)]TJ /Span<>> BDC ( )Tj EMC (\227 anas)Tj 0 Tw (-)Tj T* [(tomosis cov)13.1(ered with PM)]TJ ET q /GS0 gs 344.6119112 0 0 130.3093856 70.8661194 101.0538041 cm /Im4 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 70.8661 90.1701 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_1 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \033\025\027\021\026\031\033\032\027\ \024\024\022\022 \n\022\213\027\007\025\013\200 \020\025\020\024\023\031\ \026\031\016\031\021 \021)Tj /Span<>> BDC ( )Tj EMC [(\022\024)0.5(\024\f\027\030\r\027\026\013\200 \b\032\r\033\033\020\200, \026\026 \032\ \023. \024\023.)]TJ 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf [( R)21(esults of)]TJ /Span<>> BDC ( )Tj EMC [(pneumop)46.1(ression of)]TJ /Span<>> BDC ( )Tj EMC (intestinal anastomoses, mm Hg)Tj ET 1 0.68 0 0.12 k /GS0 gs 157.661 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 167.2109 315.4346 Tm (A)Tj ET 1 0.68 0 0.12 k 271.457 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 281.0117 315.4346 Tm (\224)Tj ET 1 0.68 0 0.12 k 385.929 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 395.4786 315.4346 Tm (\026)Tj ET 1 0.68 0 0.12 k 497.906 306.666 25.512 25.512 re f BT 0 0 0 0 k /T1_3 1 Tf 11 0 0 11 508.0544 315.4346 Tm (\027)Tj 1 0.68 0 0.12 k /T1_4 1 Tf 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.14 56.0378 Tm (68)Tj ET endstream endobj 1263 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   ####''',,,   ####''',,,""  !1A"2Qq#a $%&'()*3456789:BCDEFGHIJRSTUVWXYZbcdefghijrstuvwxyz 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Tw 0 -1.218 TD (\n\036\027\036\027\017\016 \024\002\030\026\006\024\r \023\024\035\017\n\ \036\030\027\t\b \n\036\n\002\030\026\027, \030\026\030\026\002\024\021\ \026\027)Tj 0 Tw (-)Tj 0.058 Tw T* (\027\t\b \007\035\016 \023\030\024\235\017\035\026\022\021\017\022\017 \027\ \036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 \022\017\001\036\ \004\027\t\b )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\024\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_1 1 Tf 0.01 Tc 0.018 Tw 14 0 0 14 42.5896 420.3799 Tm [(\207)21(\026)45(\024\034\033\031\026)-10(\r\233)5( \031)5(\016)-18.3(\207\034)-31(\024)35(\037\230\233)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc -0.008 Tw 10 0 0 10 42.5197 396.0239 Tm (\212\017\026\005\027 \017\f\f\035\036\007\024\r\026\027\017\016: \220\022\ \f\023\036\030\017\n\036\027\021\026\035\034\027\024\036 \024\007\027\024\ \006\036\027\021)Tj 0 Tw (-)Tj -0.007 Tw T* (\030\024\r\024\036 \f\030\026\r\027\017\021\036\035\034\027\024\036 \023\ \030\024\f\023\036\022\021\017\r\027\024\036 \f)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\f\021\t\n \024\f\035\036)Tj 0 Tw (-)Tj 0.081 Tw T* (\023\035\036\027\017\036\n. \222\030\024\022\017 \017\f\f\035\036\007\024\ \r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 1 \n\036\f\016\006. \025\024\027\036\004\027\026\016 )Tj 0.207 Tw T* (\021\024\004\022\026 \017\f\f\035\036\007\024\r\026\027\017\016)Tj /Span<>> BDC ( )Tj EMC 8.92 0 Td (\227 \031\030\024\r\036\027\034 \r\027\031\021\030\017\023\030\024\f\r\036\ \021\027\024\020\024 )Tj 0 Tw -8.92 -1.218 Td (\007\026\r\035\036\027\017\016 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\017\f\021\036\004\036\027\017\017 \r\024\007\031\b\026 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026\f\021\024\n\024\026.)Tj 0.176 Tw T* (\200 \022\026\004\036\f\021\r\036 \n\026\021\036\030\017\026\035\024\r \017\ \f\f\035\036\007\024\r\026\027\017\016 \017\f\023\024\035\034\024\r\026\ \035\017 )Tj 0.204 Tw T* [(\024\002\030\026\006\t \n\027\024\020\024\f\035\024\005\027\t\b )0.5(\023\024\035\017\n\036\030\027\t\b \n\036\n\002\030\026\027 \(\215\204\)\ , )]TJ 0.061 Tw T* (\030\026\030\026\002\024\021\026\027\027\t\b \022\024\035\035\036\022\021\ \017\r\024\n \026\r\021\024\030\024\r \(\020\030\031\023\023\t \2231\226\ 5\) )Tj 0.149 Tw T* ([11], \026)Tj /Span<>> BDC ( )Tj EMC (\r \022\026\004\036\f\021\r\036 \020\030\031\023\023\t \f\030\026\r\027\036\ \027\017\016, \017\f\023\024\035\034\031\036\n\t\036 )Tj 0.214 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 \023\030\026\022\021\017\022\036\ \017\007\036\035\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 \n\036\n\002\030\026\027\026 \017\n)Tj 0 Tw (-)Tj T* (\023\035\026\027\021\017\030\031\036\n\026\016 \002\017\024\023\024\035\017\ \n\036\030\027\026\016 \(\020\030\031\023\023\026 \2236\) \(\221\026\002\ \035.)Tj /Span<>> BDC ( )Tj EMC (1\).)Tj -0.026 Tw T* [(\210\f\024\002\036\027\027\024\f\021\034\033 )0.6(\215\204 )0.5(\016\r\035\016\036\021\f\016 )0.5(\017\b )0.5(\021\030\036\b\f\035\024\005\027\024\036 )0.6(\f\021\030\024\036\027\017\036: )]TJ 0.161 Tw T* (\023\036\030\r\t\005 \f\035\024\005, \024\002\030\026\013\036\027\027\t\005\ \022)Tj /Span<>> BDC ( )Tj EMC (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017, \r\t)Tj 0 Tw (-)Tj 0.032 Tw T* (\023\024\035\027\036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\027\026\021\030\017\036\r\024\005 \f\024\035\017 \022\026\030\002\024\022\ \f\017\n\036\021\017\035\006\036\035\035\033\035\024\t )Tj 0.211 Tw T* (\(Na-\025\204\037\), \023\030\036\023\016\021\f\021\r\031\036\021 \030\026\ \r\017\021\017\033 \f\023\026\036\004\027\t\b \f\030\026\013\036)Tj 0 Tw (-)Tj -0.001 Tw T* (\027\017\005, \r\021\024\030\024\005 \f\035\024\005 \r\t\023\024\035\027\ \036\027 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\035\036\027\027\024 \002\017\024\007\036\020\030\026\007\017)Tj 0 Tw (-)Tj 0.161 Tw T* (\030\031\036\n\024\020\024 \n\026\021\036\030\017\026\035\026 \(\202\035\ \034\020\017\027\026\021 \027\026\021\030\017\016\), \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\f\021\026\r\035\016\036\021 )Tj 0.143 Tw T* (\235\024\030\n\024\024\002\030\026\031\033\013\031\033 \004\026\f\021\034\ \215\204, \026)Tj /Span<>> BDC ( )Tj EMC (\021\030\036\021\017\005 \f\035\024\005, \023\030\017\035\036)Tj 0 Tw (-)Tj 0.025 Tw T* (\020\026\033\013\017\005 \022)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \026\027\026\f\021\024\n\024\026, \r\t\023\024\035\027\036\ \027 \017)Tj /Span<>> BDC ( )Tj EMC (\r\024\007\024\030\026\f\021\r\024)Tj 0 Tw (-)Tj 0.259 Tw T* (\030\017\n\024\020\024 \023\024\035\017\n\036\030\026)Tj /Span<>> BDC ( )Tj EMC (\227 \023\024\035\017\r\017\027\017\035\023\017\030\030\024\035\017\007\024\ \027 \(\215\200\215\), )Tj 0.298 Tw T* (\024\002\031\f\035\026\r\035\017\r\026\036\021 \235\017\022\f\026\006\017\ \033 \215\204 \026)Tj /Span<>> BDC ( )Tj EMC (\f\004\036\021 \r\t\030\026\032\036\027\027\024\005 )Tj 0 Tw T* (\026\007\020\036\017\r\027\024\005 \f\023\024\f\024\002\027\024\f\021\017\ .)Tj 0.11 Tw T* (\200 \022\026\004\036\f\021\r\036 \024\002\255\036\022\021\026 \017\f\f\035\ \036\007\024\r\026\027\017\016 \002\t\035\017 \017\f\023\024\035\034\024\ \r\026)Tj 0 Tw (-)Tj 0.008 Tw T* (\027\t \031\004\026\f\021\022\017 \021\024\027\022\024\005 \022\017\001\022\ \017 \007\035\017\027\024\005 7 \f\n, \001\017\030\017\027\024\005 2 \f\n\ , )Tj 0.171 Tw T* (\017\255\016\021\t\036 \031)Tj /Span<>> BDC ( )Tj EMC (\007\036\f\016\021\017 \021\030\031\023\024\r \035\017\006 \n\031\032\f\022\ \024\020\024 \023\024\035\026, \031\n\036\030)Tj 0 Tw (-)Tj 0.066 Tw T* (\001\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\r\024\030\026\f\021\036 \024\021 30 \007\024)Tj /Span<>> BDC ( )Tj EMC (45 \035\036\021, \027\036 \017\n\036\033\013\017\b \r)Tj /Span<>> BDC ( )Tj EMC (\026\027\026\n)Tj 0 Tw (-)Tj 0.194 Tw T* (\027\036\036 \f\017\f\021\036\n\027\t\b \026\002\024\035\036\r\026\027\ \017\005, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022\032\036 \026\002\024\035\036\r\026\027\017\005 )Tj 0.638 Tw 23.244 43.841 Td (\024\030\020\026\027\024\r \032\036\035\031\007\024\004\027\024-\022\017\ \001\036\004\027\024\020\024 \021\030\026\022\021\026 \(\023\030\024\021\ \024\022\024\035 )Tj 0.083 Tw T* (\217\233\025 \223 2 \024\021 29 \n\026\016 2025 \020.\). \003\026\002\024\ \030 \n\026\021\036\030\017\026\035\026, \026)Tj /Span<>> BDC ( )Tj EMC (\021\026\022)Tj 0 Tw (-)Tj 0.308 Tw T* (\032\036 \017\f\f\035\036\007\024\r\026\027\017\016 \024\f\031\013\036\f\ \021\r\035\016\035\017 \r)Tj /Span<>> BDC ( )Tj EMC (\021\036\004\036\027\017\036 \023\036\030\r\t\b )Tj 0.024 Tw T* (\f\031\021\024\022 \f)Tj /Span<>> BDC ( )Tj EMC (\n\024\n\036\027\021\026 \027\026\f\021\031\023\035\036\027\017\016 \f\n\ \036\030\021\017. \211\004\026\f\021\022\017 \021\024\027\022\024\005 )Tj 0.088 Tw T* (\022\017\001\022\017 \030\026\f\f\036\022\026\035\017 \023\024\023\036\030\ \036\004\027\024, \026\021\036\n \r\024\f\f\021\026\027\026\r\035\017\r\ \026\035\017 )Tj 0.09 Tw T* [(\027\036\023\030\036\030\t\r\027\024\f\021\034 \023\031\021\036\n \027\026\ \035\024\032\036\027\017\016 )0.5(\022\017\001\036\004\027\024\020\024 \026\027\026\f\021\024)]TJ 0 Tw (-)Tj 0.309 Tw T* [(\n\024\026 )0.5(\023\024)]TJ /Span<>> BDC ( )Tj EMC 4.045 0 Td [(\021\017\023\031 )0.6(\253\022\024\027\036\006-\r-\022\024\027\036\006\273, )0.6(\022\024\021\024\030\t\036 )0.5(\031\022\030\t\r\026\035\017 )]TJ 0.112 Tw -4.045 -1.218 Td (\017\f\f\035\036\007\031\036\n\t\n\017 \215\204 \(\217\017\f.)Tj /Span<>> BDC ( )Tj EMC (1\). \200)Tj /Span<>> BDC ( )Tj EMC (\022\026\032\007\024\005 \020\030\031\023\023\036 \017\f\f\035\036)Tj 0 Tw (-)Tj 0.139 Tw T* (\007\024\r\026\027\017\016 \r\t\023\024\035\027\036\027\024 \023\024)Tj /Span<>> BDC ( )Tj EMC (10 \026\027\026\f\021\024\n\024\024\r \026\021\030\026\r\n\026\021\017\004\ )Tj 0 Tw (-)Tj 0.027 Tw T* (\027\024\005 \027\017\021\034\033 \(\215\024\035\017\020\035\026\022\021\ \017\027 3/0\). \221\026\022\032\036 \r)Tj /Span<>> BDC ( )Tj EMC (\017\f\f\035\036\007\024\r\026\027\017\036 )Tj 0.244 Tw T* (\r\022\035\033\004\017\035\017 \036\013\036 \007\r\036 \020\030\031\023\023\ \t \002\036 \017\f\023\024\035\034\024\r\026\027\017\016 \215\204: )Tj 0.204 Tw T* (\020\030\031\023\023\026 \2237)Tj /Span<>> BDC ( )Tj EMC (\227 \024\007\027\024\030\016\007\027\t\005 \027\036\023\030\036\030\t\r\ \027\t\005 \024\002\r\017\r\027\024\005 )Tj 0.004 Tw T* (\026\027\026\f\021\024\n\024 \004\036\030\036 \r\f\036 \f\035\024\017 \ \022\017\001\036\004\027\024\005 \f\021\036\027\022\017\) \017)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\026 )Tj 0.131 Tw T* (\223 8)Tj /Span<>> BDC ( )Tj EMC (\227 \007\r\031\030\016\007\027\t\005 \026\027\026\f\021\024\n\024, \023\ \036\030\r\t\005 \030\016\007 \022\024\021\024\030\024\020\024 )Tj 0.048 Tw T* (\007\024\023\024\035\027\036\027 \r\021\024\030\t\n \030\016\007\024\n \031\ \035\024\r\t\b \f\036\030\024\027\024-\n\t\001\036\004\027\t\b )Tj -0.018 Tw T* [(\001\r\024\r. \215\024\f\035\036 \235\024\030\n\017\030\024\r\026\027\017\ \016 \026\027\026\f\021\024\n\024\026 )0.5(\017\f\f\035\036\007\031\036\n\t\005 )]TJ 0.078 Tw T* [(\235\030\026\020\n\036\027\021 )0.5(\021\024\027\022\024\005 \022\017\001\022\017 )0.5(\023\024\n\036\013\026\035\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 16.127 0 Td (\007\027\024 \022\024\027\021\036\005\027\036)Tj 0 Tw (-)Tj 0.059 Tw -16.127 -1.218 Td (\030\026, \026\023\024\035\027\036\027\027\024\020\024 \r\024\007\024\005\ , \f)Tj /Span<>> BDC ( )Tj EMC (\024\007\027\024\005 \017)Tj /Span<>> BDC ( )Tj EMC (\f\021\024\030\024\027 \023\030\024\017\r\024)Tj 0 Tw (-)Tj 0.296 Tw T* (\007\017\035\f\016 \023\030\024\022\024\035 \017\027\255\036\022\006\017\ \024\027\027\024\005 \017\020\035\024\005, \023\024\007\022\035\033\004\036\ \027\027\024\005 )Tj 0.151 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\f\024\036\007\017\027\017\021\036\035\034\027\024\005 \021\030\031\002\022\ \036 \026\r\021\024\n\026\021\017\004\036\f\022\024\020\024 \021\024\027\ \024\n\036\021)Tj /Span<>> BDC (-)Tj EMC 0.08 Tw T* (\030\026 \f)Tj /Span<>> BDC ( )Tj EMC (\023\024\n\024\013\034\033 \f\017\f\021\036\n\t \007\035\016 \r\027\031\021\ \030\017\r\036\027\027\t\b \r\035\017\r\026\027\017\005. )Tj 0.136 Tw T* (\215\030\017)Tj /Span<>> BDC ( )Tj EMC (\026\023\031\f\022\036 \021\024\027\024\n\036\021\030\026 \r\024\007\031\ \b \026\023\024\035\027\016\035 \024\023\017\f\026\027\027\031\033 )Tj 0.099 Tw T* [(\f\017\f\021\036\n\031 [12]. \215\024\022\026\026\021\036\035\034 )0.5(\n\026\022\f\017\n\026\035\034\027\024 \007\024\f\021\017\020\027\031\021\ \024\020\024 )]TJ 0.07 Tw T* (\007\026\r\035\036\027\017\016 \(\n\n \030\021. \f\021.\) \n\026\027\024\ \n\036\021\030 \030\036\020\017\f\021\030\017\030\024\r\026\035 \026\r\021\ \024)Tj 0 Tw (-)Tj 0.216 Tw T* [(\n\026\021\017\004\036\f\022\017. \212\035\016 \023\024\r\t\001\036\027\017\ \016 )0.5(\021\024\004\027\024\f\021\017 \017\f\f\035\036\007\024\r\026\027\017\016\ )]TJ 0.154 Tw T* (\023\030\024\r\024\007\017\035\017 \r\017\007\036\024\235\017\022\f\026\006\ \017\033 \022\026\032\007\024\020\024 \220\021\026\023\026 \017\f\f\035\036\ \007\024)Tj 0 Tw (-)Tj 0.146 Tw T* (\r\026\027\017\016, \021\026\022\032\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\t\023\024\035\027\036\027\017\017 \017\f\f\035\036\007\024\r\026\027\017\ \016 \017\f\023\024\035)Tj 0 Tw (-)Tj 0.224 Tw T* (\027\017\021\036\035\036\005 \027\036 \017\027\235\024\030\n\017\030\024\ \r\026\035\017 \024)Tj /Span<>> BDC ( )Tj EMC (\023\030\017\027\026\007\035\036\032\027\024\f\021\017 \024\002)Tj 0 Tw (-)Tj 0.017 Tw T* (\030\026\006\026 \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\027\022\030\036\021\027\024\005 \020\030\031\023\023\036 \017\f\ \f\035\036\007\024\r\026\027\017\016, \001\017\235\030\031\016 \017\b )Tj 0 Tw T* (\027\026\017\n\036\027\024\r\026\027\017\016.)Tj /T1_4 1 Tf 0 -2.436 TD (\030\002\001\002\007\220\002\007\006\n\220\235\007\240 \001\005\001\003\007\ \255)Tj /T1_2 1 Tf 0.146 Tw 0 -1.218 TD [(\222\021\026\021\017\f\021\017\004\036\f\022\031\033 )0.5(\024\002\030\026\002\024\021\022\031 \023\024\035\031\004\036\027\027\t\b\ \007\026\027\027\t\b \023\030\024)]TJ 0 Tw (-)Tj 0.107 Tw T* [(\r\024\007\017\035\017 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 4.133 0 Td [(\023\030\024\020\030\026\n\n\036 )0.5(S)15(t)15(a)15(t)-32(ist)-31.9(ica )0.5(v. )0.5(13.0 )0.5(\(TIBC)13(O, )0.5(\222\231\202\). )]TJ 0.213 Tw -4.133 -1.218 Td (\203\036\023\030\036\030\t\r\027\t\036 \007\026\027\027\t\036 \023\030\036\ \007\f\021\026\r\035\036\027\t \r)Tj /Span<>> BDC ( )Tj EMC (\r\017\007\036 \n\036\007\017\026)Tj 0 Tw (-)Tj 0.088 Tw T* (\027\t, 25 \017)Tj /Span<>> BDC ( )Tj EMC [(75 \023\030\024\006\036\027\021\017\035\036\005 )0.5(\(\204\036 [25; 75]\). \215\030\017)]TJ /Span<>> BDC ( )Tj EMC (\f\030\026\r\027\036)Tj 0 Tw (-)Tj 0.038 Tw T* (\027\017\017 \023\024\035\031\004\036\027\027\t\b \027\026\004\036\027\017\ \005 \r)Tj /Span<>> BDC ( )Tj EMC (\f\r\016\017 \f)Tj /Span<>> BDC ( )Tj EMC (\n\026\035\024\005 \r\t\002\024\030\022\024\005 )Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf 0 Tw 9 0 0 9 42.5197 730.483 Tm (\020\004\206\f\t\204\004 1.)Tj 0 0 0 1 k /GS1 gs /T1_3 1 Tf ( \205\031\024\023\020\021 \022\024\024\f\027\030\r\027\026\013\200 \033\031\ \f\022\026\027\032\025\013\200 \026\027\026\240\032\020\025 \021)Tj /Span<>> BDC ( )Tj EMC [(\b\032\r\033\033\020\200 \022\024\024\f\027\030)0.5(\031\021\020\025\022\t, \026\b/\024\026)]TJ 5.247 0 0 5.247 357.6124 733.48 Tm (2)Tj 1 0.68 0 0.12 k /GS0 gs /T1_5 1 Tf -0.027 Tc 0.027 Tw 9 0 0 9 42.5197 719.683 Tm [(T)0.5(a)-35.3(b)-40.7(l)-38.7(e)-27( 1)-24.5(.)]TJ 0 0 0 1 k /GS1 gs /T1_3 1 Tf 0 Tc 0 Tw 3.324 0 Td [( C)1.2(o)-4(m)-1(p)-9.1(o)-1(s)-12.5(i)-3.4(t)-29.1(i)-1.4(o)-4(n o)4(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-10.5(h)-2.4(e s)-14.8(t)-1.1(u)-5.9(d)-3(i)-1.4(e)-12.9(d p)-9.1(o)-5.3(l)6.6(y)-4.8(m)-5.3(e)-6(r m)-5.2(e)-7(m)2(b)-3.5(r)3.3(a)-5.1(n)-2.4(e)-22(s i)4(n t)-10.6(h)-2.4(e)]TJ /Span<>> BDC ( )Tj EMC [(s)-14.8(t)-1.1(u)-5.9(d)-7.2(y g)-1.4(r)-2(o)-3.4(u)-2.3(p)1.8(s)-23.3(, m)-1(g)-9.2(/)65.8(c)-6.6(m)]TJ 5.247 0 0 5.247 340.7453 722.68 Tm (2)Tj ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 73.9508 715.181 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 73.9508 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 198.6752 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 198.6752 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 297.8878 715.181 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 397.1004 715.181 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 42.7697 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 73.9508 703.7117 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 73.9508 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.6752 703.7117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 198.6752 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 703.7117 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 397.1004 703.7117 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 682.9005 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 682.6505 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 73.9508 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.4252 682.6505 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 682.6505 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 397.1004 682.6505 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 496.313 661.8392 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 661.5892 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 73.9508 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 198.4252 661.5892 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 661.5892 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 397.1004 661.5892 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 631.1779 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 630.9279 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 73.9508 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 198.4252 630.9279 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 630.9279 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 397.1004 630.9279 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 600.5166 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 600.2666 cm 0 0 m 31.681 0 l S Q q 1 0 0 1 42.7697 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 73.9508 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 198.4252 600.2666 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 198.6752 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 297.8878 600.2666 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 397.1004 600.2666 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 397.1004 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 496.313 569.8553 cm 0 0 m 0 30.161 l S Q q 1 0 0 1 42.5197 569.6053 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 42.7697 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 73.9508 569.6053 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 73.9508 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 198.6752 569.6053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 198.6752 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 297.8878 569.6053 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 397.1004 569.6053 cm 0 0 m 99.463 0 l S Q q 1 0 0 1 496.313 548.7941 cm 0 0 m 0 20.561 l S Q q 1 0 0 1 42.5197 548.5441 cm 0 0 m 31.431 0 l S Q q 1 0 0 1 73.9508 548.5441 cm 0 0 m 124.724 0 l S Q q 1 0 0 1 198.6752 548.5441 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 297.8878 548.5441 cm 0 0 m 99.213 0 l S Q q 1 0 0 1 397.1004 548.5441 cm 0 0 m 99.463 0 l S Q BT /GS1 gs /T1_5 1 Tf 8 0 0 8 46.2045 706.5463 Tm (\027\006\210\212\212\004)Tj 7.894 0 Td (\200\006\002\t\213\002\240\t\003\r\f\001)Tj 15.948 0 Td (1 \217\f\002\005)Tj 12.402 0 Td (2 \217\f\002\005)Tj 12.402 0 Td (3 \217\f\002\005)Tj /T1_2 1 Tf -47.376 -1.433 Td (1)Tj 3.1 0 Td (\214\026\002\024\030\026\021\024\030\017\016 \220\022\f\023\036\030\017\n\ \036\027\021\026\035\034\027\024\005 )Tj 2.224 -1.2 Td (\b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\024\027\022\024\035\024\020\017\017, )Tj -1.149 -1.2 Td (\017\f\023\t\021\026\021\036\035\034\027\026\016 \035\026\002\024\030\026\ \021\024\030\017\016 )Tj -0.465 -1.2 Td (\n\036\007\017\006\017\027\f\022\017\b \017\007\036\035\017\005 \203\230\ \230 \233\204 )Tj 5.114 -1.2 Td (\025\206\204\211,)Tj -5.469 -1.2 Td (\203\230\214 \024\030\020\026\027\017\004\036\f\022\024\020\024 \f\017\027\ \021\036\026 \025\206\211)Tj 19.016 6 Td (Na-\025\204\037)Tj -0.049 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.83 -1.2 Td (9,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 13.196 1.2 Td (\215\200\215)Tj -0.794 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1)Tj -47.125 -1.433 Td (2)Tj 18.607 0 Td (Na-\025\204\037)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\214\036\r\024\235\035\024\022\f\026\006\017\027)Tj 1.326 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2/1,05)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,05)Tj 13.961 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.83 -1.2 Td (9,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 13.196 1.2 Td (\215\200\215)Tj -0.794 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1)Tj -47.125 -1.433 Td (3)Tj 22.371 0 Td (Na-\025\204\037)Tj -0.049 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.213 -1.2 Td (+)Tj /Span<>> BDC ( )Tj EMC (\247\024\020\036\022\f\024\035)Tj -1.273 -1.2 Td (9,3)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3/4,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 15.085 2.4 Td (\215\200\215)Tj -0.794 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1)Tj -47.125 -2.633 Td (4)Tj 22.371 0 Td (Na-\025\204\037)Tj -0.049 -1.2 Td (9,4)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 1.2 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.213 -1.2 Td (+)Tj /Span<>> BDC ( )Tj EMC (\247\024\020\036\022\f\024\035)Tj -1.273 -1.2 Td (9,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3/4,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.321 2.4 Td (\215\200\215)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\214\036\r\024\235\035\024\022\f\026\006\017\027)Tj 0.581 -1.2 Td (5,0)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,1/0,73)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,07)Tj -44.736 -2.633 Td (5)Tj 19.042 0 Td (Na-\025\204\037)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\020\017\026\035\031\030\024\027\024\r\026\016 )Tj 1.669 -1.2 Td (\022\017\f\035\024\021\026 \(\f\n\036\f\034\))Tj 1.611 -1.2 Td (9,7)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj 11.572 2.4 Td (\202\035\034\020\017\027\026\021 Na)Tj 0.58 -1.2 Td (10,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,3)Tj 10.01 1.2 Td (\215\200\215)Tj /Span<>> BDC ( )Tj EMC (+)Tj /Span<>> BDC ( )Tj EMC (\204\036\021\030\024\027\017\007\026\024\035)Tj 0.752 -1.2 Td (4,2)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2/1,8)Tj /Span<>> BDC ( )Tj EMC (\261)Tj /Span<>> BDC ( )Tj EMC (0,2)Tj -45.236 -2.633 Td (6)Tj 3.944 0 Td (\230\f\023\024\035\034\031\036\n\026\016 \r)Tj /Span<>> BDC ( )Tj EMC (\022\035\017\027\017\004\036\f\022\024\005 )Tj 4.173 -1.2 Td (\023\030\026\022\021\017\022\036)Tj 13.472 1.2 Td (\204\036\n\002\030\026\027\026 \017\n\023\035\026\027\021\017\030\031\036\ \n\026\016 \002\017\024\023\024\035\017\n\036\030\027\026\016 \(\002\026\ \022\021\036\030\017\026\035\034\027\t\005 \f\024\023\024\035\017\n\036\030\ )Tj 4.037 -1.2 Td (\023\024\035\017\024\022\f\017\002\031\021\017\030\026\021\026 \f)Tj /Span<>> BDC ( )Tj EMC (\r\026\035\036\030\026\021\024\n, \023\024\035\017\220\021\036\035\036\027\ \020\035\017\022\024\035\034\))Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_6 1 Tf 25 0 0 25 512.9018 56.0378 Tm (67)Tj ET endstream endobj 1260 0 obj <>stream q /GS0 gs /Fm0 Do Q 0 0 0 1 K 1 j 1 J [0 2.997]0 d /GS1 gs q 1 0 0 1 74.3631 505.5841 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 505.5841 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q [0 2.997]0 d q 1 0 0 1 74.3631 468.3763 cm 0 0 m 448.048 0 l S Q []0 d q 1 0 0 1 71.3661 468.3763 cm 0 0 m 0 0 l 452.543 0 m 452.543 0 l S Q 0 j 0 J q 1 0 0 1 70.8661 414.3071 cm 0 0 m 453.543 0 l S Q BT 0 0 0 1 k /T1_0 1 Tf 0.118 Tw 9 0 0 9 119.0551 730.4919 Tm [(MA)45(TERIAL)-27.9(S A)53(ND METHODS: )0.5(the )0.5(mater)-37(ials )0.5(of )0.5(the p)46(resent )0.5(study )0.5(w)12(ere ne)10(w )0.5(sam)16(ples \(g)14(roups N)17(o. )0.5(1\2315\) of )0.5(multilayer )]TJ 0.113 Tw 0 -1.111 TD [(polymer membranes \(5 g)14(roups dif)-40(fer)-37(ing in com)16(position with addition )0.5(of v)16(ar)-37(ious antibacter)-37(ial ag)12(ents, a contrast )]TJ 0.029 Tw T* [(ag)12(ent in dif)-39.9(ferent layers\) and the membrane, the im)16(planted biopolymer \(g)14(roup N)17(o. 6\). S)28.1(tudy design: e)-15(xper)-36.9(imental )]TJ 0.051 Tw T* [(sing)13(le-center com)16(parativ)13.1(e p)45.9(rospectiv)13.1(e with sim)16.1(ple blinding. S)28(tudy ter)-14(ms)]TJ /Span<>> BDC ( )Tj EMC (\227 1 month. The end point of the study is )Tj 0.022 Tw T* [(the lev)13(el of intraluminal p)46(ressure at the air e)-15(xpiration in the anastomosis zone. The ef)-40(fectiv)13(eness studies w)12(ere con)]TJ 0 Tw (-)Tj 0.02 Tw 0 -1.111 TD [(ducted by pneumop)46(ressing \(using an automatic tonometer\) a section of the s)33(mall intestine af)-45.9(ter applying a sing)13(le-)]TJ -0.002 Tw 0 -1.111 TD [(row intestinal anastomosis, on which the test sam)16(ples w)12(ere placed. The p)46(ressure inside the sing)13(le-row \(g)14(roup 7\) and )]TJ -0.009 Tw T* [(double-row \(g)14(roup 8\) anastomoses w)13(as also measured without the use of membranes. The study used 7 cm long \ and )]TJ 0.028 Tw T* [(2 cm wide sections of the s)32.9(mall intestine tak)17(en from ten male cad)26(av)13(ers ag)12(ed betw)12(een 30 and 45. The sam)16(ples w)12(ere )]TJ 0.023 Tw T* [(collected within 24 hours of death. Each g)14(roup included 10 sam)16(ples.)]TJ 0.029 Tw T* [(RESUL)30(T)-10(S: the highest median of p)46(ressure v)16(alue \(85 [79.5; 87] mm Hg\) w)13(as obser)-42(v)13(ed in g)14(roup 8 \(double-row anas)]TJ 0 Tw (-)Tj 0.025 Tw T* [(tomosis\), with a median dif)-39.9(ference of 0.5 com)16(pared to g)14(roup 1 \(84.5 [83; 85] mm Hg\) \(using membranes without )]TJ 0.013 Tw T* [(antibacter)-36.9(ial ag)12.1(ents\) and g)14(roup )0.5(4 \(84.5 [83.25; 86] )0.5(mm Hg\) \(using )0.5(membranes with Lev)13(of)-21.9(lo)14(x)10(acin in the PVP layer )]TJ 0.021 Tw T* [(and )0.6(Y)48(og)12(e)-15(xol )0.5(in )0.5(the )0.6(sodium )0.6(alginate )0.5(layer\). )0.6(How)12(ev)13(er)61(, )0.6(the )0.5(v)16(alues )0.6(of )0.5(g)14(roup )0.6(8 )0.5(are )0.5(statistically )0.5(signif)-43(icantly )0.5(higher )0.5(than )]TJ 0.093 Tw 0 -1.111 TD [(the v)16(alues of g)14(roups 6 \(62 [60.5; 63] mm Hg\) and 7 \(63.5 [59.5; 65.75] mm Hg\) by 23\ \(p)]TJ /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0.002\) and 21.5 )Tj 0.023 Tw 0 -1.111 TD (\(p)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC [(0.004\) respectiv)13(ely)32(.)]TJ 0.133 Tw T* [(C)21(ON)22(CLUSION: the study sugg)12(ests that the mechanical shelter of the intestinal anastomosis with ne)10(w membrane )]TJ 0.023 Tw T* [(sam)16(ples is a fairly ef)-40(fectiv)13(e method for p)46(rev)13(enting their failure.)]TJ /T1_1 1 Tf 0.01 Tc -0.01 Tw 8 0 0 8 70.9061 545.2226 Tm [(KEYW)22(ORDS:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.948 0 Td [( surgical membranes, polymers, antibacter)-36.9(ial ag)12(ents, e)-15(xper)-37(iment, intestinal anastomoses, tightness)]TJ /T1_1 1 Tf 0.01 Tc 0.018 Tw -4.948 -1.909 Td [(C)19(ONFL)-33(ICT)5( OF)]TJ /Span<>> BDC 5.312 0 Td ( )Tj EMC [(INTE)25(REST)61.9(:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.559 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC [(authors declare no conf)-22(lict of)]TJ /Span<>> BDC ( )Tj EMC (interest)Tj /T1_1 1 Tf 0.01 Tc -0.01 Tw -9.871 -1.909 Td [(FIN)16(A)31(N)23(CIN)23(G:)]TJ /T1_0 1 Tf 0 Tc 0.023 Tw 4.966 0 Td ( the)Tj /Span<>> BDC ( )Tj EMC (study had no sponsorship)Tj /T1_1 1 Tf 0.057 Tc 0.064 Tw -4.966 -2.617 Td [(F)3.2(O)-4.6(R)8.7( C)-17.5(I)-15.6(T)45.4(A)37.6(T)-24.5(I)-1.3(ON:)]TJ /T1_2 1 Tf 0.043 Tc 0.073 Tw 6.769 0 Td [( L)-41.1(a)-27.5(z)-27.5(a)-10.2(r)-19.1(e)-11.4(n)-8.8(k)-3.7(o)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-23(.)-23.5(, L)-12.2(i)-2.5(p)-20(a)-18.2(t)-21.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(V)39.7(.)-23.9(A)-23(.)-23.5(, S)-29.3(e)-15.8(v)-18.7(e)-12.1(r)-56.4(i)-3.2(n)-11.9(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.8(A)-23(.)-23.5(, K)-15.9(u)-10.4(d)-10.4(r)-60.6(y)-24.2(a)-10.7(v)-54.9(t)-48.9(s)-22.9(e)-15.8(v)-28.4(a)]TJ /Span<>> BDC ( )Tj EMC [(T)52.5(.)-1.9(N)-2.8(.)-23.5(, K)-11.1(o)-9.2(m)-8.3(a)-10.2(r)-15.8(o)-10.3(v)]TJ /Span<>> BDC ( )Tj EMC [(D)16.4(.)-23.9(A)-23(. Ef)-62.5(f)-28.5(e)-19.1(c)-41.5(t)-46.2(i)-14.5(v)-18.7(e)-11.5(n)-16(e)-22.8(s)-22.3(s o)-12.1(f n)-16.1(e)-12.5(w p)-22.3(o)-15.7(l)-8.2(y)-27.5(m)-16.6(e)-12.1(r)43( )]TJ 0.028 Tc -0.035 Tw -6.774 -1.2 Td [(m)-16.1(e)-11.1(m)-7.9(b)-13.3(r)-30.4(a)-7.1(n)-15.6(e)-22.4(s f)-24.8(o)-11.3(r i)-2.7(n)-16.9(t)-24.2(e)-22.4(s)-28.8(t)-45.7(i)-2.7(n)-7.4(a)-10.9(l a)-7.1(n)-7.4(a)-26.1(s)-28.8(t)-21.4(o)-8.8(m)-11.9(o)-15.4(s)-22.4(e)-22.3(s)-15.1(. )]TJ /T1_0 1 Tf 0.034 Tc -0.034 Tw [(K)10.3(o)-3.6(lo)-3.6(p)-1.1(rok)-22.7(t)-1.3(o)-3.7(lo)-6.8(g)-16.7(i)3.1(a)2.3(.)]TJ /T1_2 1 Tf 0.028 Tc -0.035 Tw 24.473 0 Td [( 2)-8.4(0)-3.3(2)4.6(6)20.4(;)10.3(2)-1(5)1.4(\()38.2(1)44.7(\))15(:)4.6(6)-2(5)-22.2(\226)44.7(7)11.7(0)7(. \(i)-2.7(n R)-6(u)-21.5(s)-21.8(s)-15(.)43.7(\))10.8(. h)-16.7(t)-49(t)-28.9(p)-18.2(s)-7.5(:)2.3(/)85.2(/)36.9(d)-10.7(o)-12(i.)3.1(o)-11.3(r)-16.2(g)-22.3(/)11.6(1)14.5(0)6.9(.)-5.1(3)8.4(3)-15.5(8)1.8(7)5.1(8/)8.4(2)-8.4(0)9.7(7)-1.4(3)-12.8(-)41.6(7)11.2(5)0.9(5)-8.5(6)-26.2(-)10.2(2)-8.5(0)-3.3(2)4.7(6)-26.3(-)]TJ 0.067 Tc -0.067 Tw -24.473 -1.2 Td [(2)22.6(5)0.5(-)79.1(1)50.9(-)-4(6)21.6(5)0.5(-)65.2(7)35.2(0)]TJ /T1_1 1 Tf 0.01 Tc 0.057 Tw 0.005 -2.617 Td [(\026\020\021\033\030)5( \020\036\017)5( \013\033\021\033\013\023\030\037\023:)]TJ /T1_0 1 Tf 0 Tc 0.062 Tw 10.655 0 Td ( \205\027\021\027\032\022\025\031\021 \220\026\022\023\032\022\235 \003\025\ \030\032\027\027\021\022\007, \214\216\221\217\210 \211\217 \202\216\215\ \210 \215\022\025\016\030\032\020\021\020 \206\031\024\024\022\022, \r\f\ .)Tj /Span<>> BDC ( )Tj EMC (\202.)Tj /Span<>> BDC ( )Tj EMC (\215\020\032\n\024\020, \030.)Tj /Span<>> BDC ( )Tj EMC (3, \202\r\032\024\n, 305041, \206\031\024\024\022\t; )Tj 0.023 Tw -10.66 -1.2 Td (\023\027\f.:)Tj /Span<>> BDC ( )Tj EMC (+7)Tj /Span<>> BDC ( )Tj EMC (\(920\) 262-15-55; e-mail: dmitriy.severinov.93@mail.ru)Tj /T1_1 1 Tf 0.01 Tc 0.09 Tw 0.005 -1.2 Td [(ADDRESS)5( F)13(OR)5( C)19(ORRESPONDEN)23(CE:)]TJ /T1_0 1 Tf 0 Tc 0.095 Tw 14.195 0 Td [( Dmitr)-42.9(y A. Sev)13(er)-36.9(inov)63(, K)17(ursk S)28(tate Medical U)22(niv)13(ersity)42(, K. Mar)-32(x st., 3, K)17(ursk, 305041, R)22(ussia; e-mail: dmitr)-36.9(iy)32(.)]TJ 0 Tw -14.199 -1.2 Td [(sev)13(er)-37(inov)53(.93@mail.ru)]TJ 0 -2.792 TD (\220\020\023\020 \033\031\024\023\r\033\f\027\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 28.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (\004\031\024\f\027 \030\031\032\020\240\031\023\n\022)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (\004\032\022\025\t\023\031 \n)Tj /Span<>> BDC ( )Tj EMC (\033\r\240\f\022\n\020\006\022\022)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj ( )Tj -38.268 -1.375 Td (Received)Tj /Span<>> BDC ( )Tj EMC (\227 28.08.2025)Tj /Span<>> BDC ( )Tj EMC 19.488 0 Td (Revised)Tj /Span<>> BDC ( )Tj EMC (\227 19.12.2025)Tj /Span<>> BDC ( )Tj EMC 18.78 0 Td (Accepted for publication)Tj /Span<>> BDC ( )Tj EMC (\227 17.02.2026)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 70.936 359.4899 Tm (\023\023\034\230\034\022\031\034)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0.147 Tw 10 0 0 10 70.8661 335.1339 Tm [(\210\023\036\030\026\006\017\017 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC [(\024\030\020\026\027\026\b )0.5(\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\032\036\035\031\007\024\004)Tj 0 Tw (-)Tj 0.134 Tw 0 -1.218 TD (\027\024-\022\017\001\036\004\027\024\n \021\030\026\022\021\036 \(\240\025\ \221\) \016\r\035\016\033\021\f\016 \027\026\017\002\024\035\036\036 \030\ \026\f)Tj 0 Tw (-)Tj 0.533 Tw T* (\023\030\024\f\021\030\026\027\201\027\027\t\n\017 \r\026\030\017\026\027\ \021\026\n\017 \b\017\030\031\030\020\017\004\036\f\022\017\b \r\n\036)Tj 0 Tw (-)Tj 0.342 Tw T* (\001\026\021\036\035\034\f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\027\026\f\021\024\016\013\036\036 \r\030\036\n\016 [1]. \203\036\024\021\ \255\036\n\035\036\n\t\n )Tj 0.128 Tw T* (\220\021\026\023\024\n \024\f\027\024\r\027\024\005 \n\026\f\f\t \024\023\ \036\030\026\006\017\005 \027\026)Tj /Span<>> BDC ( )Tj EMC (\030\026\035\017\004\027\t\b \024\021)Tj 0 Tw (-)Tj 0.196 Tw T* (\007\036\035\026\b \240\025\221 \016\r\035\016\036\021\f\016 \235\024\030\ \n\017\030\024\r\026\027\017\036 \022\017\001\036\004\027\t\b \026\027\026\ )Tj 0 Tw (-)Tj 0.272 Tw T* (\f\021\024\n\024\024\r \(\025\202\) \007\035\016 \r\024\f\f\021\026\027\ \024\r\035\036\027\017\016 \027\036\023\030\036\030\t\r\027\024\f\021\017\ )Tj 0.081 Tw T* (\022\017\001\036\004\027\017\022\026 [2]. \203\036\f\n\024\021\030\016 \027\ \026)Tj /Span<>> BDC ( )Tj EMC (\027\026\004\017\021\036\035\034\027\t\036 \007\024\f\021\017\032\036)Tj 0 Tw (-)Tj 0.105 Tw T* [(\027\017\016 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC 2.65 0 Td (\b\017\030\031\030\020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC 5.01 0 Td [(\002\017\024\017\027\032\036\027\036\030\017\017, )0.5(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\034 )]TJ 0.029 Tw -7.66 -1.218 Td (\022\017\001\036\004\027\t\b \026\027\026\f\021\024\n\024\024\r \(\203\025\ \202\) \024\f\021\026\201\021\f\016 \027\026\004\017\021\036\035\034\027\ \024\005 )Tj 0.153 Tw T* (\031\020\030\024\024\005 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017\024\ \027\027\024\n \023\036\030\017\024\007\036 [3]. )Tj 0.146 Tw T* (\203\025\202)Tj /Span<>> BDC ( )Tj EMC (\227 \007\024\f\021\026\021\024\004\027\024 \017\031\004\036\027\027\024\ \036 \024\f\035\024\032\027\036\027\017\036, \022\024\021\024\030\024\036\ )Tj 0.173 Tw T* (\023\030\017\r\024\007\017\021 \022)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\017\021\024\027\017\021\031 \017)Tj /Span<>> BDC ( )Tj EMC (\n\027\024\020\024\220\021\026\023\027\t\n \023\024\r\021\024\030\027\t\n\ )Tj 0.139 Tw T* [(\b\017\030\031\030\020\017\004\036\f\022\017\n )0.6(\r\n\036\001\026\021\036\035\034\f\021\r\026\n, )0.6(\026)]TJ /Span<>> BDC ( )Tj EMC 14.717 0 Td [(\r )0.5(\f\035\031\004\026\036 )0.6(\023\024\007\027\036\005 )]TJ 0.058 Tw -14.717 -1.218 Td (\007\017\026\020\027\024\f\021\017\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 \035\036\021\026\035\034\027\024\n\031 \017\f\b\024\007\031 [4]. \215\ \030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \004\026)Tj 0 Tw (-)Tj 0.228 Tw T* (\f\021\024\021\026 \027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\ \021\017 \026\r\017\f\017\021 \024\021 \n\027\024\020\017\b \235\026\022\ \021\024)Tj 0 Tw (-)Tj 0.252 Tw T* (\030\024\r. \221\026\022, \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \220\027\021\036\030\024-\220\ \027\021\036\030\024\026\027\026\f\021\024)Tj 0 Tw (-)Tj 0.261 Tw T* [(\n\024\026 )0.5(\004\026\f\021\024\021\026 )0.6(\027\036\f\024\f\021\024\016\021\036\035\034\027\024\f\021\017 )0.6(\027\036 )0.5(\023\030\036\r\t\001\026\036\021 )0.6(3% )]TJ 0.005 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\023\035\026\027\024\r\t\b \r\n\036\001\026\021\036\035\034\f\021\r\026\b\ , \026)Tj /Span<>> BDC ( )Tj EMC (\r \031\030\020\036\027\021\027\t\b \f\035\031\004\026\016\b )Tj -0.027 Tw T* (\007\024\f\021\017\020\026\036\021 9,8% [5]. \222\021\024\017\021 \024\021\ \n\036\021\017\021\034, \004\021\024 \203\025\202 \004\026\013\036 \r\024\ )Tj 0 Tw (-)Tj 0.02 Tw T* (\027\017\022\026\036\021 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\235\024\030\n\017\030\024\r\026\027\017\017 \253\027\017\022\017\b\273\ \022\024\035\024\030\036\022\021\026\035\034\027\t\b )Tj 0 Tw T* (\026\027\026\f\021\024\n\024\024\r [6].)Tj 0.03 Tc 0.089 Tw 23.244 28.009 Td (\210\f\024\002\031\033 \020\030\031\023\023\031 \023\026\006\017\036\027\ \021\024\r \235\024\030\n\017\030\031\033\021 \023\024\f\021\030\026\007\ \026\r)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.185 Tw T* (\001\017\036 \r)Tj /Span<>> BDC ( )Tj EMC (\030\036\031\035\034\021\026\021\036 \007\024\030\024\032\027\024-\021\030\ \026\027\f\023\024\030\021\027\t\b \023\030\024\017\f)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.213 Tw T* [(\001\036\f\021\r\017\005, \022\024\020\007\026 \017\n\036\033\021 \n\036\ \f\021\024 \030\026\030\t\r\t \022\017\001\036\004\027\024\005)30( )]TJ 0.399 Tw T* (\f\021\036\027\022\017, \017)Tj /Span<>> BDC ( )Tj EMC (\024\023\036\030\026\021\017\r\027\t\036 \r\n\036\001\026\021\036\035\034\ \f\021\r\026 \023\036\030\r\017\004)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc 0.507 Tw T* (\027\024 \r\t\023\024\035\027\016\033\021\f\016 \r)Tj /Span<>> BDC ( )Tj EMC [(\031\f\035\024\r\017\016\b \017\027\235\017\006\017\030\024\r\026\027\027\ \024\005)30( )]TJ 0.115 Tw T* [(\002\030\033\001\027\024\005 )0.5(\023\024\035\024\f\021\017 [7]. )0.5(\221\026\022\032\036 \036\013\036 \002\024\035\036\036 \021\016\032\036\035\ \024\005)30( )]TJ 0.183 Tw T* (\022\026\021\036\020\024\030\017\036\005 \023\026\006\017\036\027\021\024\ \r \016\r\035\016\033\021\f\016 \030\026\027\036\027\t\036 \r)Tj /Span<>> BDC ( )Tj EMC [(\b\024\007\036)30( )]TJ -0.013 Tw T* [(\r\024\036\027\027\t\b )0.5(\022\024\027\235\035\017\022\021\024\r )0.5(\017-\026 )0.5(\r\t\f\024\022\024\005 )0.5(\220\027\036\030\020\017\017 )0.5(\021\030\026\r)]TJ 0 Tc 0 Tw (-)Tj 0.03 Tc 0.116 Tw T* [(\n\017\030\031\033\013\036\020\024 )0.5(\026\020\036\027\021\026 )0.5(\(\023\031\035\017, )0.5(\024\f\022\024\035\022\017\), )0.5(\004\021\024 )0.6(\023\030\017\r\024\007\017\021)30( )]TJ 0.072 Tw T* (\022)Tj /Span<>> BDC ( )Tj EMC (\023\030\024\027\017\022\026\033\013\017\n \030\026\027\036\027\017\016\n\ \002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\036\036)30( )]TJ 0.633 Tw T* [(\n\026\f\f\017\r\027\024\005 \024\002\f\036\n\036\027\036\027\027\024\f\021\ \017 \n\017\022\030\024\024\030\020\026\027\017\n\026\n\017)30( )]TJ 0.065 Tw T* [([8]. \233\021\024 )0.5(\024\022\026\t\r\026\036\021 \024\021\030\017\006\026\021\036\035\034\027\ \024\036 \r\035\017\016\027\017\036 \027\026)]TJ /Span<>> BDC ( )Tj EMC (\004\026)Tj 0 Tc 0 Tw (-)Tj 0.03 Tc T* (\f\021\024\021\031 \203\025\202)Tj /Span<>> BDC ( )Tj EMC ([9].)Tj 0.016 Tc 0.371 Tw T* [(\212\035\016 \023\030\024\235\017\035\026\022\021\017\022\017 \203\025\202\ , \031\f\022\024\030\036\027\017\016 \030\036\020\036\027\036\030\026\006\ \017\017)16( )]TJ 0.069 Tw T* (\021\022\026\027\036\005 \r)Tj /Span<>> BDC ( )Tj EMC (\024\027\036 \025\202 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\r\t\001\036\027\017\016 \220\235\235\036\022\021\017\r\027\024\f\ \021\017 \b\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc -0.02 Tw T* (\030\031\030\020\017\004\036\f\022\017\b \r\n\036\001\026\021\036\035\034\ \f\021\r \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\027\036\n \023\024\f\035\036\024\023\036\030\026\006\017)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.225 Tw T* (\024\027\027\024\n \023\036\030\017\024\007\036 \030\026\030\026\002\026\ \021\t\r\026\033\021\f\016 \027\024\r\t\036 \002\017\024\n\026\021\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.224 Tw T* [(\030\017\026\035\t, \f\024\007\036\030\032\026\013\017\036 \026\027\021\017\ \002\026\022\021\036\030\017\026\035\034\027\t\036 \f\030\036\007\f\021\r\ \026.)16( )]TJ 0.315 Tw T* [(\221\026\022\017\036 \017\007\036\035\017\016 \(\023\035\036\027\022\017\ , \n\036\n\002\030\026\027\t\), \024\002\035\026\007\026\033\013\017\036\ )16( )]TJ 0.473 Tw T* [(\030\016\007\024\n \023\024\017\021\017\r\027\t\b \f\r\024\005\f\021\r,\ \021\026\022\017\b \022\026\022 \r\t\f\024\022\026\016)16( )]TJ 0.273 Tw T* (\026\007\020\036\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\022\017\001\036\004\027\024\005 \f\021\036\027\022\036, \002\017\024\007\ \036\020\030\026\007\026\006\017\016, \021\030\036)Tj 0 Tc 0 Tw (-)Tj 0.016 Tc 0.351 Tw T* [(\002\031\033\021 \r\f\036\f\021\024\030\024\027\027\036\020\024 \021\036\ \f\021\017\030\024\r\026\027\017\016 [10]. \200\026\032\027\t\n)16( )]TJ 0.148 Tw T* (\220\021\026\023\024\n \016\r\035\016\036\021\f\016 \024\006\036\027\022\ \026 \020\036\030\n\036\021\017\004\027\024\f\021\017 \025\202 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC [(\017\b)16( )]TJ -0.016 Tw T* (\017\f\023\024\035\034\024\r\026\027\017\017.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_4 1 Tf 0 Tc 0 Tw 7.5 0 0 7.5 70.8661 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj -51.938 -95.622 Td [(\037)31(\036\035\036\034\033\036\037\032)20(\036\035\036\031\030\027, \026)11(\025\024 2)23(5, \023\0221)69(, 202)46(6)]TJ 43.059 0 Td [(K)20(OL)30(OPROKT)20(OL)30(OGIA)-30.9(, v)10(ol. 2)23(5, \023\0221)69(, 202)46(6)]TJ /T1_5 1 Tf 25 0 0 25 28.1274 56.0378 Tm (66)Tj ET endstream endobj 1233 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1234 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1235 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1236 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/TrimBox[0.0 0.0 566.929 793.701]/Type/Page>> endobj 1237 0 obj 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0 10 42.5197 724.8299 Tm (https://doi.org/10.33878/2073-7556-2026-25-1-65-70)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0.023 Tw 19 0 0 19 74.5551 695.3259 Tm [(\036\004\t\r\017 \237\216\216\004\r)-9.9(\026\n\b\t\025\016)-10(\026\n \224\005\n\024\004\t\004\t\n\213 \224\025\020\n\024\004\005\t\217\ \220 )]TJ 2.546 -1.105 Td [(\024\004\024\255\005\017\t \202)-21(\020\213 \r\n\204\004\225\t\217\220 \017\t\017\016)-10(\026)11(\025\024\025)21(\212\025\b)]TJ 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 649.822 Tm [(\035\017\212\017\005\004\t\r)10(\025\022)-23.2(\021.\f)-31(.)]TJ 8.162 0 0 8.162 134.7965 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 139.4325 649.822 Tm [(, \035\n\224\017\026)11(\025\b\022)-23.2(\021.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 224.1394 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 228.7753 649.822 Tm [(, \001\004\b\004\005\n\t\025\b\022)-23.2(\201.\f)-31(.)]TJ 0 Tw 8.162 0 0 8.162 329.652 654.484 Tm (1)Tj 0.023 Tw 14 0 0 14 334.2879 649.822 Tm [(, \037)62(\002\202\005\213\b\004\b\017\022)-23.2(\032.\007.)]TJ 0 Tw 8.162 0 0 8.162 435.823 654.484 Tm (2)Tj 14 0 0 14 440.4589 649.822 Tm (, )Tj -28.424 -1.143 Td [(\037)31(\025\024\017\005\025\b\022)-23.3(\201.\f)-30.9(.)]TJ 8.162 0 0 8.162 123.639 638.484 Tm (1)Tj 5.83 0 0 5.83 42.5197 619.4827 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 616.1527 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\005\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \024\004\202\n\n\t\016\r\n\221 \002\t\n\b\004\005\ \016\n\026)11(\004\026\273 \235\n\t\212\202\005\017\b\017 \033\025\016\016\n\n \(\002\020\ .\022)-23.3(\037.\022)-23.3(\235\017\005\r\016\017, \202.\022)-23.3(3, )]TJ -0.331 -1.2 Td [(\013)62(.\022)-23.3(\037)62(\002\005\016\r, 3050)25.1(4)103(1)69(, \033\025\016\016\n\213\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 595.4827 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 592.1527 Tm [(\210\031\006)21(\036)20(\227 \021\036 \253\037)62(\002\005\016\r\n\221 \013)10(\025\016\002\202\017\005\016)-9.9(\026\b\004\t\t\217\221 \002\t\n\b\004\005\016\n\026)11.1(\004\026\273 \(\002\020.\022)-23.2(\033\017\202\n\234\004\b\017, \202.\022)-23.2(33, \013)62(.\022)-23.3(\037)62(\002\005\016\r, 305000, \033\025\016\016\n\213\))]TJ /T1_1 1 Tf -0.016 Tw 9 0 0 9 90.7087 573.6488 Tm (\037\036\035\034: \021)Tj /Span<>> BDC ( )Tj EMC (\204\n\024\033\027\032\022\026\027\025\023\027 ex vivo \031\006\027\025\022\ \023\017 \204\203\203\027\n\023\022\021\025\031\024\023\017 \033\032\022\ \026\027\025\027\025\022\t \031\240\032\020\016\006\031\021 \033\031\f\022\ \026\027\032\025\013\200 \026\027\026\240\032\020\025, \032\020\016\032\020\ \240\031)Tj 0 Tw (-)Tj 0.023 Tw 0 -1.111 TD (\023\020\025\025\013\200 \030\f\t \033\032\031\203\022\f\020\n\023\022\n\ \022 \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\022 \n\ \022\213\027\007\025\013\200 \020\025\020\024\023\031\026\031\016\031\021\ .)Tj 0.027 Tw T* (\215\003\036\206\002\003\035\201 \002)Tj /Span<>> BDC ( )Tj EMC (\215\036\217\220\201: \026\020\023\027\032\022\020\f\020\026\022 \025\020\ \024\023\031\t\212\027\b\031 \022\024\024\f\027\030\031\021\020\025\022\t\ \024\023\020\f\022 \031\240\032\020\016\006\013 \026\025\031\b\031\024\f\ \031\235\025\013\200 \033\031\f\022\026\027\032\025\013\200 )Tj 0.086 Tw T* (\026\027\026\240\032\020\025 \(\b\032\r\033\033\013 \2421\2315, \031\023\ \f\022\007\020\005\212\022\027\024\t \024\031\024\023\020\021\031\026 \024\ )Tj /Span<>> BDC ( )Tj EMC (\030\031\240\020\021\f\027\025\022\027\026 \032\020\016\f\022\007\025\013\ \200 \020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\013\200 \024\ \032\027\030\024\023\021, )Tj -0.029 Tw T* (\n\031\025\023\032\020\024\023\025\031\b\031 \021\027\212\027\024\023\021\ \020 \021)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\f\022\007\025\013\027 \024\f\031\022\) \022)Tj /Span<>> BDC ( )Tj EMC (\022\024\033\031\f\017\016\r\027\026\020\t \021)Tj /Span<>> BDC ( )Tj EMC (\n\f\022\025\022\007\027\024\n\031\235 \033\032\020\n\023\022\n\027 \026\ \027\026\240\032\020\025\020, \022\026\033\f\020\025\023\022\032\r)Tj 0 Tw (-)Tj -0.05 Tw 0 -1.111 TD (\027\026\020\t \240\022\031\033\031\f\022\026\027\032\025\020\t \(\b\032\ \r\033\033\020 \2426\). \220\022\016\020\235\025 \022\024\024\f\027\030\031\ \021\020\025\022\t: \204\n\024\033\027\032\022\026\027\025\023\020\f\017\ \025\031\027 \031\030\025\031\006\027\025\023\032\031\021\031\027 \024\032\ \020\021\025\022\023\027\f\017\025\031\027 )Tj 0.078 Tw 0 -1.111 TD (\033\032\031\024\033\027\n\023\022\021\025\031\027 \024)Tj /Span<>> BDC ( )Tj EMC (\033\032\031\024\023\013\026 \031\024\f\027\033\f\027\025\022\027\026. \205\ \032\031\n\022 \022\024\024\f\027\030\031\021\020\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 1 \026\027\024\t\006. \202\031\025\027\007\025\020\t \023\031\007\n\ \020 \022\024\024\f\027\030\031\021\020\025\022\t)Tj /Span<>> BDC ( )Tj EMC (\227 )Tj 0.018 Tw T* [(\r\032\031\021\027\025\017 \021\025\r\023\032\022\033\032\031\024\021\027\ \023\025\031\b\031 )0.5(\030\020\021\f\027\025\022\t )0.5(\033\032\022)]TJ /Span<>> BDC ( )Tj EMC [(\022\024\023\027\007\027\025\022\022 )0.5(\021\031\016\030\r\200\020 )0.5(\021)]TJ /Span<>> BDC ( )Tj EMC [(\016\031\025\027 \020\025\020\024\023\031\026\031\016\020. )0.5(\002\024\024\f\027\030\031\021\020\025\022\t \204\203\203\027\n\023\022\021\ )]TJ 0 Tw (-)Tj 0.021 Tw T* (\025\031\024\023\022 \033\032\031\021\031\030\022\f\022 \033\r\023\027\026\ \033\025\027\021\026\031\033\032\027\024\024\022\022 \(\024 \033\031\026\ \031\212\017\005 \020\021\023\031\026\020\023\022\007\027\024\n\031\b\031\ \023\031\025\031\026\027\023\032\020\) \r\007\020\024\023\n\020 \023\031\ \025\n\031\235 \n\022\213\n\022 )Tj 0.13 Tw T* (\033\031\024\f\027 \025\020\f\031\255\027\025\022\t \031\030\025\031\032\ \t\030\025\031\b\031 \n\022\213\027\007\025\031\b\031 \020\025\020\024\023\ \031\026\031\016\020, \025\020)Tj /Span<>> BDC ( )Tj EMC (\f\022\025\022\005 \213\021\031\021 \n\031\023\031\032\031\b\031 \033\031\ \026\027\212\020\f\022 \023\027\024\023\022\032\r\027\026\013\027 )Tj 0.124 Tw T* (\031\240\032\020\016\006\013. \020\n\255\027 \022\016\026\027\032\t\f\022\ \030\020\021\f\027\025\022\027 \021\025\r\023\032\022 \031\030\025\031\032\ \t\030\025\031\b\031 \(\b\032\r\033\033\020 \2427\) \022)Tj /Span<>> BDC ( )Tj EMC (\030\021\r\032\t\030\025\031\b\031 \020\025\020\024\023\031\026\031\016\031\ \021 \(\b\032\r\033\033\020 )Tj 0.068 Tw T* (\242 8\) \240\027\016 \022\024\033\031\f\017\016\031\021\020\025\022\t \026\ \027\026\240\032\020\025. \211)Tj /Span<>> BDC ( )Tj EMC (\n\020\007\027\024\023\021\027 \031\240\236\027\n\023\020 \022\024\024\f\ \027\030\031\021\020\025\022\t \240\013\f\022 \022\024\033\031\f\017\016\ \031\021\020\025\013 \r\007\020\024\023\n\022 \023\031\025\n\031\b\031 )Tj -0.01 Tw T* (\n\022\213\027\007\025\022\n\020 \030\f\022\025\031\235 7 \024\026, \213\ \022\032\022\025\031\235 2 \024\026, \022\016\236\t\023\013\027 \r)Tj /Span<>> BDC ( )Tj EMC (\030\027\024\t\023\022 \023\032\r\033\031\021 \f\022\006 \026\r\255\024\n\ \031\b\031 \033\031\f\020, \r\026\027\032\213\022\200 \021)Tj /Span<>> BDC ( )Tj EMC (\021\031\016\032\020\024\023\027 \031\023 )Tj 0.067 Tw T* (30 \030\031)Tj /Span<>> BDC ( )Tj EMC (45 \f\027\023. \207\020\240\031\032 \026\020\023\027\032\022\020\f\020, \ \020)Tj /Span<>> BDC ( )Tj EMC (\023\020\n\255\027 \022\024\024\f\027\030\031\021\020\025\022\t \031\024\ \r\212\027\024\023\021\f\t\f\022 \021)Tj /Span<>> BDC ( )Tj EMC (\023\027\007\027\025\022\027 \033\027\032\021\013\200 \024\r\023\031\n \024\ )Tj /Span<>> BDC ( )Tj EMC (\026\031\026\027\025\023\020 )Tj 0.023 Tw 0 -1.111 TD (\025\020\024\023\r\033\f\027\025\022\t \024\026\027\032\023\022. \211)Tj /Span<>> BDC ( )Tj EMC (\n\020\255\030\031\235 \b\032\r\033\033\027 \021\013\033\031\f\025\027\025\ \031 \033\031)Tj /Span<>> BDC ( )Tj EMC (10 \022\024\024\f\027\030\031\021\020\025\022\235.)Tj 0.046 Tw 0 -1.111 TD (\206\036\207\210\035\034\003\201: \024\031\b\f\020\024\025\031 \033\031\ \f\r\007\027\025\025\013\026 \021)Tj /Span<>> BDC ( )Tj EMC (\200\031\030\027 \022\024\024\f\027\030\031\021\020\025\022\t \030\020\025\ \025\013\026, \022\026\027\005\023\024\t \024\023\020\023\022\024\023\022\ \007\027\024\n\022 \016\025\020\007\022\026\013\027 \031\023\f\022)Tj 0 Tw (-)Tj 0.157 Tw T* [(\007\022\t )0.5(\026\027\255\030\r )0.5(\b\032\r\033\033\020\026\022 )0.5(\(\032)]TJ /Span<>> BDC ( )Tj EMC 10.33 0 Td (=)Tj /Span<>> BDC ( )Tj EMC 0.89 0 Td [(0,00002\). )0.5(\001\020\022\240\031\f\017\213\027\027 )0.5(\016\025\020\007\027\025\022\027 )0.6(\026\027\030\022\020\025\013 )0.5(\030\020\021\f\027\025\022\t \(85 [79,5; )0.5(87] )0.5(\026\026 )0.5(\032\023. )0.5(\024\023.\) )]TJ -0.011 Tw -11.22 -1.111 Td (\033\032\022)Tj /Span<>> BDC ( )Tj EMC (\033\025\027\021\026\031\033\032\027\024\024\022\022 \024\203\031\032\026\ \022\032\031\021\020\025\025\013\200 \n\022\213\027\007\025\013\200 \020\ \025\020\024\023\031\026\031\016\031\021 \021\013\t\021\f\027\025\031 \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\027 \2428 \(\030\021\r\032\t\030\025\013\235 \020\025\020\ \024\023\031\026\031\016\), )Tj -0.007 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\032\020\016\025\022\006\027\235 \026\027\030\022\020\025 \021)Tj /Span<>> BDC ( )Tj EMC (0,5 \031\023\026\027\007\027\025\013 \016\025\020\007\027\025\022\t \021\ )Tj /Span<>> BDC ( )Tj EMC (\b\032\r\033\033\020\200 \2421 \(84,5 [83; 85] \026\026 \032\023. \024\023\ .\) \(\024 \022\024\033\031\f\017\016\031\021\020\025\022\027\026 \026\027\ \026)Tj 0 Tw (-)Tj 0.006 Tw T* (\240\032\020\025 \240\027\016 \021\025\027\024\027\025\022\t \020\025\023\ \022\240\020\n\023\027\032\022\020\f\017\025\013\200 \024\032\027\030\024\ \023\021\) \022)Tj /Span<>> BDC ( )Tj EMC (\2424 \(84,5 [83,25; 86] \026\026 \032\023. \024\023.\) \(\026\027\026\240\ \032\020\025\020 \024)Tj /Span<>> BDC ( )Tj EMC (\021\025\027\024\027\025\022\027\026 )Tj -0.023 Tw T* (\035\027\021\031\203\f\031\n\024\020\006\022\025\020 \021)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\235 \004\211\004 \022)Tj /Span<>> BDC ( )Tj EMC (\246\031\b\027\n\024\031\f\020 \021)Tj /Span<>> BDC ( )Tj EMC (\024\f\031\235 \003\f\017\b\022\025\020\023\020 \025\020\023\032\022\t\)\ . \217\030\025\020\n\031 \016\025\020\007\027\025\022\t \b\032\r\033\033\ \013 \2428 \024\023\020\023\022\024\023\022)Tj 0 Tw (-)Tj 0.044 Tw T* (\007\027\024\n\022 \016\025\020\007\022\026\031 \033\032\027\031\240\f\020\ \030\020\027\023 \023\031\f\017\n\031 \025\020\030 \016\025\020\007\027\025\ \022\t\026\022 \b\032\r\033\033 \2426 \(62 [60,5; 63] \026\026 \032\023.\ \024\023.\) \022)Tj /Span<>> BDC ( )Tj EMC (\2427 \(63,5 [59,5; )Tj 0.023 Tw T* (65,75] \026\026 \032\023. \024\023.\) \025\020)Tj /Span<>> BDC ( )Tj EMC (23 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,002\) \022)Tj /Span<>> BDC ( )Tj EMC (21,5 \(\032)Tj /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (0,004\), \024\031\031\023\021\027\023\024\023\021\027\025\025\031.)Tj 0.246 Tw 0 -1.111 TD [(\207\003\202\035\224\232\036\001\002\036: )0.5(\033\032\031\021\027\030\027\025\025\031\027 )0.5(\022\024\024\f\027\030\031\021\020\025\022\027 )0.6(\033\031\016\021\031\f\t\027\023 )0.5(\r\023\021\027\032\255\030\020\023\017, \007\023\031 \026\027\200\020\025\ \022\007\027\024\n\031\027 )0.5(\r\n\032\013\023\022\027 )0.5(\016\031\025\013 \202\003 )]TJ 0.023 Tw 0 -1.111 TD (\025\031\021\013\026\022 \031\240\032\020\016\006\020\026\022 \004\215 \t\ \021\f\t\027\023\024\t \033\031\023\027\025\006\022\020\f\017\025\013\026\ \026\027\023\031\030\031\026 \033\032\031\203\022\f\020\n\023\022\n\022\ \025\027\024\031\024\023\031\t\023\027\f\017\025\031\024\023\022 \202\003\ .)Tj /T1_2 1 Tf 0.01 Tc 0.092 Tw 8 0 0 8 42.5596 318.3795 Tm [(\037\036\035\034\033\032\031\033)5( \030\036\027\032\026:)]TJ /T1_1 1 Tf 0 Tc 0.097 Tw 8.566 0 Td [( \200\022\032\r\032\b\022\007\027\024\n\022\027 )0.5(\026\027\026\240\032\020\025\013, )0.5(\033\031\f\022\026\027\032\013, )0.5(\020\025\023\022\240\020\n\023\027\032\022\020\f\017\025\013\027 )0.5(\024\032\027\030\024\023\021\020, \204\n\024\033\027\032\022\026\027\025\ \023, )0.5(\n\022\213\027\007\025\013\027 \020\025\020\024\023\031\026\031\016\013,\ )0.6(\b\027\032\026\027)]TJ 0 Tw (-)Tj -8.571 -1.2 Td (\023\022\007\025\031\024\023\017)Tj /T1_2 1 Tf 0.01 Tc 0.018 Tw 0.005 -1.909 Td [(\037\027\025\024\036\023\037\022)5( \023\025\022\033\021\033\030\027\032:)]TJ /T1_1 1 Tf 0 Tc 0.023 Tw 10.401 0 Td ( \020\021\023\031\032\013 \016\020\t\021\f\t\005\023 \031\240 \031\023\024\ \r\023\024\023\021\022\022 \n\031\025\203\f\022\n\023\020 \022\025\023\027\ \032\027\024\031\021)Tj /T1_2 1 Tf 0.01 Tc -0.01 Tw -10.401 -1.909 Td (\024\023\025\026\025\030\023\021\027\032\026\025\023\033:)Tj /T1_1 1 Tf 0 Tc 0.023 Tw 8.655 0 Td ( \022\024\024\f\027\030\031\021\020\025\022\027 \025\027 \022\026\027\f\031\ \024\033\031\025\024\031\032\024\n\031\235 \033\031\030\030\027\032\255\ \n\022)Tj /T1_2 1 Tf 0.04 Tc 0.345 Tw -8.655 -2.617 Td [(\020\036\017)4.6( \016\023\022\023\021\027\032\026\025\023\017:)]TJ /T1_3 1 Tf 0.03 Tc 0.35 Tw 9.631 0 Td ( \214\026\026\030\036\027\022\024)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \214\017\023\026\021\024\r)Tj /Span<>> BDC ( )Tj EMC (\200.\202., \222\036\r\036\030\017\027\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202., \025\031\007\030\016\r\006\036\r\026)Tj /Span<>> BDC ( )Tj EMC (\221.\203., \025\024\n\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\212.\202. \210\006\036\027\022\026 \220\235\235\036\022\021\017\r)Tj 0 Tc 0 Tw (-)Tj 0.023 Tc 0.257 Tw -9.636 -1.2 Td [(\027\024\f\021\017 )0.5(\023\030\017\n\036\027\036\027\017\016 )0.5(\027\024\r\t\b )0.5(\023\024\035\017\n\036\030\027\t\b )0.5(\n\036\n\002\030\026\027 )0.5(\007\035\016 )0.5(\022\017\001\036\004\027\t\b )0.5(\026\027\026\f\021\024\n\024\024\r. )]TJ /T1_1 1 Tf -0.023 Tw 35.244 0 Td (\202\031\f\031\033\032\031\n\023\031\f\031\b\022\t.)Tj /T1_3 1 Tf 0.257 Tw [( )0.5(2026; \021.)]TJ /Span<>> BDC ( )Tj EMC 12.802 0 Td [(25, )0.5(\223)]TJ /Span<>> BDC ( )Tj EMC [(1, )0.5(\f.)]TJ /Span<>> BDC ( )Tj EMC 5.678 0 Td [(65\22670.)23( )]TJ -0.023 Tw -53.724 -1.2 Td (https://doi.org/10.33878/2073-7556-2026-25-1-65-70)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 0 Tc 0.023 Tw 18 0 0 18 121.9353 205.7639 Tm [(Ef)-31(fectiv)12.1(eness of ne)11.1(w polymer membr)21(anes )]TJ 3.063 -1.167 Td (for intestinal anastomoses)Tj 0 0 0 1 k /GS1 gs 0 Tw 14 0 0 14 42.5197 160.26 Tm [(Victor\022)-23.2(A)-31(.\022)-23.3(La)20(z)15(ar)31(enk)11(o)]TJ 8.162 0 0 8.162 153.4764 164.922 Tm (1)Tj 0.023 Tw 14 0 0 14 158.1123 160.26 Tm [(, Viach)11(eslav\022)-23.2(A)-31(.\022)-23.3(Lipatov)]TJ 0 Tw 8.162 0 0 8.162 287.0907 164.922 Tm (1)Tj 0.023 Tw 14 0 0 14 291.7266 160.26 Tm [(, Dmitriy\022)-23.2(A)-31(.\022)-23.3(Se)11(v)12(erinov)]TJ 0 Tw 8.162 0 0 8.162 414.8666 164.922 Tm (1)Tj 14 0 0 14 419.5026 160.26 Tm (, )Tj -26.927 -1.143 Td [(T)40(at)-20(y)21(ana\022)-23.2(N.\022)-23.3(K)31(udr)-31(y)21(avtse)11(v)10(a)]TJ 8.162 0 0 8.162 184.0384 148.922 Tm (2)Tj 0.023 Tw 14 0 0 14 188.6743 144.26 Tm [(, Dmitr)-30.9(y\022)-23.3(A)-31(.\022)-23.3(K)41(omar)20(ov)]TJ 0 Tw 8.162 0 0 8.162 304.5911 148.922 Tm (1)Tj 5.83 0 0 5.83 42.5197 129.9208 Tm (1)Tj 0.023 Tw 10 0 0 10 45.8311 126.5908 Tm [(K)31(ur)20(sk State Medical Univ)12.1(er)20(sit)-20(y \(K. Marx\022)-23.3(st., 3, K)31(ur)20(sk, 3050)25.1(4)103(1)69(, Russia\))]TJ 0 Tw ( )Tj 5.83 0 0 5.83 42.5197 117.9208 Tm (2)Tj 0.023 Tw 10 0 0 10 45.8311 114.5908 Tm [(K)31(ur)20(sk State Univ)12(er)20(sit)-19.9(y \(Radishch)11(e)11(v)10(a\022)-23.3(st., 33, K)31(ur)20(sk, 305000, Russia\))]TJ /T1_1 1 Tf 0.047 Tw 9 0 0 9 90.7087 96.0869 Tm [(AIM: ev)16(aluate )0.5(the ef)-40(fectiv)13(eness )0.5(of ne)10(w polymer membranes )0.5(for p)46(rev)13(ention of intestinal anastomoses leak)11(ag)12(e in e)-15(x )]TJ 0.023 Tw T* [(viv)13(o e)-15(xper)-36.9(iment.)]TJ ET 1 0.68 0 0.12 k /GS0 gs q 1 0 0 1 42.5197 582.1533 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 0 Tw 9 0 0 9 47.6607 573.226 Tm (\021\033\r\035\f\033)Tj ET 1 0.68 0 0.12 k q 1 0 0 1 42.5197 104.5913 cm 0 0 m 0 0 l 0 -11.339 l 42.52 -11.339 l 42.52 0 l h f Q BT 0 0 0 0 k /T1_2 1 Tf 9 0 0 9 45.2263 95.664 Tm (ABSTRACT)Tj 1 0.68 0 0.12 k /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_4 1 Tf 25 0 0 25 512.7895 56.0378 Tm (65)Tj ET q 0 g 0 G 0 j 0 J /Fm1 Do Q 0 0 0 0 k 368.504 725.67 59.155 11.338 re f /PlacedPDF /MC0 BDC q 369.135 736.808 m 368.896 736.808 368.703 736.616 368.703 736.376 c 368.703 736.376 l 368.703 726.285 l 368.703 726.045 368.896 725.853 369.135 725.853 c 369.135 725.853 l 427.035 725.853 l 427.273 725.853 427.469 726.045 427.469 726.285 c 427.469 726.285 l 427.469 736.376 l 427.469 736.616 427.273 736.808 427.035 736.808 c 427.035 736.808 l h W n q 0 g -0.0000005 -10.9560913 -10.9560913 0.0000005 398.0855785 736.8086309 cm BX /Sh0 sh EX Q Q q 368.504 725.67 59.155 11.337 re W n 0 0 0 0.84 k q 1 0 0 1 385.2169 732.4249 cm 0 0 m -0.025 0.1 -0.063 0.196 -0.112 0.287 c -0.157 0.374 -0.218 0.451 -0.292 0.515 c -0.37 0.582 -0.46 0.632 -0.558 0.664 c -0.669 0.701 -0.786 0.719 -0.903 0.717 c -1.076 0.722 -1.247 0.681 -1.4 0.6 c -1.536 0.526 -1.652 0.42 -1.74 0.292 c -1.83 0.158 -1.895 0.008 -1.934 -0.149 c -2.018 -0.48 -2.018 -0.827 -1.934 -1.158 c -1.896 -1.316 -1.83 -1.466 -1.74 -1.602 c -1.653 -1.731 -1.536 -1.837 -1.4 -1.912 c -1.247 -1.993 -1.076 -2.033 -0.903 -2.029 c -0.774 -2.032 -0.647 -2.006 -0.528 -1.955 c -0.427 -1.906 -0.337 -1.837 -0.263 -1.753 c -0.185 -1.665 -0.124 -1.563 -0.082 -1.453 c -0.034 -1.338 0 -1.218 0.019 -1.094 c 0.635 -1.094 l 0.624 -1.297 0.578 -1.497 0.497 -1.684 c 0.421 -1.857 0.312 -2.015 0.175 -2.146 c 0.039 -2.277 -0.123 -2.379 -0.3 -2.446 c -0.492 -2.519 -0.695 -2.555 -0.9 -2.552 c -1.15 -2.557 -1.397 -2.506 -1.625 -2.404 c -1.829 -2.307 -2.01 -2.169 -2.157 -1.997 c -2.308 -1.821 -2.423 -1.617 -2.497 -1.397 c -2.655 -0.924 -2.655 -0.412 -2.497 0.061 c -2.423 0.281 -2.307 0.485 -2.157 0.661 c -2.01 0.833 -1.829 0.973 -1.625 1.07 c -1.398 1.174 -1.15 1.226 -0.9 1.222 c -0.707 1.223 -0.515 1.196 -0.329 1.14 c -0.159 1.088 0.001 1.006 0.144 0.898 c 0.278 0.793 0.39 0.662 0.473 0.513 c 0.562 0.349 0.615 0.167 0.629 -0.019 c 0 -0.019 l 0 0 l f Q q 1 0 0 1 386.3458 733.5723 cm 0 0 m 0.584 0 l 0.584 -1.328 l 0.662 -1.204 0.771 -1.103 0.9 -1.033 c 1.046 -0.951 1.213 -0.91 1.381 -0.914 c 1.627 -0.9 1.869 -0.979 2.058 -1.137 c 2.234 -1.312 2.325 -1.556 2.305 -1.803 c 2.305 -3.596 l 1.716 -3.596 l 1.716 -1.976 l 1.724 -1.817 1.678 -1.66 1.585 -1.53 c 1.486 -1.43 1.347 -1.379 1.206 -1.392 c 1.114 -1.39 1.024 -1.408 0.94 -1.445 c 0.865 -1.479 0.798 -1.529 0.744 -1.591 c 0.687 -1.656 0.645 -1.73 0.616 -1.812 c 0.586 -1.896 0.571 -1.986 0.571 -2.077 c 0.571 -3.615 l 0 -3.615 l 0 0 l f Q q 1 0 0 1 389.692 731.1235 cm 0 0 m 0 -0.099 0.014 -0.198 0.043 -0.292 c 0.069 -0.382 0.112 -0.466 0.17 -0.54 c 0.229 -0.611 0.304 -0.669 0.388 -0.709 c 0.486 -0.754 0.594 -0.776 0.702 -0.773 c 0.845 -0.78 0.987 -0.742 1.108 -0.664 c 1.217 -0.582 1.296 -0.468 1.336 -0.337 c 1.881 -0.337 l 1.827 -0.603 1.675 -0.838 1.456 -0.996 c 1.35 -1.073 1.231 -1.131 1.105 -1.169 c 0.971 -1.208 0.831 -1.229 0.691 -1.227 c 0.509 -1.227 0.328 -1.191 0.16 -1.121 c 0.007 -1.063 -0.13 -0.972 -0.244 -0.855 c -0.356 -0.73 -0.44 -0.583 -0.491 -0.422 c -0.548 -0.243 -0.576 -0.056 -0.574 0.133 c -0.575 0.313 -0.545 0.493 -0.486 0.664 c -0.426 0.826 -0.335 0.974 -0.22 1.102 c 0.004 1.375 0.338 1.534 0.691 1.535 c 0.883 1.539 1.072 1.495 1.243 1.408 c 1.402 1.326 1.541 1.209 1.649 1.067 c 1.759 0.922 1.838 0.757 1.883 0.582 c 1.932 0.396 1.945 0.203 1.92 0.013 c 0 0.013 l 0 0 l 1.342 0.377 m 1.335 0.468 1.315 0.557 1.283 0.643 c 1.253 0.724 1.209 0.798 1.153 0.863 c 1.097 0.922 1.03 0.97 0.957 1.004 c 0.874 1.043 0.783 1.063 0.691 1.062 c 0.6 1.062 0.509 1.044 0.425 1.009 c 0.345 0.976 0.273 0.926 0.213 0.863 c 0.153 0.799 0.105 0.724 0.072 0.643 c 0.037 0.559 0.017 0.468 0.014 0.377 c 1.355 0.377 l h f Q q 1 0 0 1 393.8116 731.7051 cm 0 0 m -0.012 0.144 -0.082 0.276 -0.194 0.366 c -0.31 0.452 -0.451 0.495 -0.595 0.489 c -0.675 0.488 -0.755 0.476 -0.831 0.452 c -0.918 0.424 -0.998 0.375 -1.062 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[(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 \220\n\005\002\005\013\n\225\ \004\016\r)10(\025\221 \224\025\024\025\234\n )]TJ 0 -1 TD [(\224\005\n\022\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\ \r\n \t\017\022\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 39.559 1 Td [(A dif)-30.9(fer)31(entiated algorithm for pr)20(oviding sur)31(gical car)31(e )]TJ 0.177 -1 Td [(for\022r)31.1(ectal injuries at th)10.9(e\022stages of\022medical e)11(v)10(acuation)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.037 Tw 10 0 0 10 42.5197 724.8299 Tm [(\021\036\b\027\017\004\036\f\022\017\b )0.6(\024\001\017\002\024\022 )0.5(\n\036\021\024\007\017\022\017 )0.6(\022\024\035\024\f\021\024\n\017\017. )0.5(\215\030\017)]TJ /Span<>> BDC ( )Tj EMC 20.306 0 Td (\r\027\036)Tj 0 Tw (-)Tj 0.185 Tw -20.306 -1.218 Td (\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\b \r)Tj /Span<>> BDC ( )Tj EMC (35,7% \022\035\017\027\017\004\036\f\022\017\b \027\026\002\035\033)Tj 0 Tw (-)Tj 0.295 Tw 0 -1.218 TD [(\007\036\027\017\005 )0.6(\023\024\021\030\036\002\024\r\026\035\026\f\034 )0.5(\030\036\036\022\006\017\016 )0.6(\023\030\016\n\024\005 )0.5(\022\017\001\022\017. )0.5(\200\024 )]TJ 0.195 Tw T* (\r\f\036\b \f\035\031\004\026\016\b \r\t\f\024\022\024\036 \r\027\036\002\ \030\033\001\017\027\027\024\036 \217\215\025 \027\036 \002\t\035\024 )Tj 0.06 Tw T* [(\030\026\f\023\024\027\026\027\024 )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.374 0 Td [(\023\030\036\007\t\007\031\013\017\b )0.6(\220\021\026\023\026\b. )0.5(\222\026\027\026\006\017\024\027\027\026\016 )0.6(\030\036)]TJ 0 Tw (-)Tj 0.074 Tw -6.374 -1.218 Td (\035\026\023\026\030\024\021\024\n\017\016 \023\030\017\n\036\027\016\035\ \026\f\034 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036 \r)Tj /Span<>> BDC ( )Tj EMC (46,2% \f\035\031)Tj 0 Tw (-)Tj -0.012 Tw 0 -1.218 TD (\004\026\036\r, \026)Tj /Span<>> BDC ( )Tj EMC (\r\024 2-\005 \020\030\031\023\023\036, \f\024\024\021\r\036\021\f\021\r\ \036\027\027\024, \r)Tj /Span<>> BDC ( )Tj EMC (54,7% \027\026\002\035\033)Tj 0 Tw (-)Tj 0.162 Tw 0 -1.218 TD (\007\036\027\017\005. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \017\027\021\031\002\026\006\017\033 \021\024\027\022\024\ \005 \022\017\001\022\017 \f)Tj /Span<>> BDC ( )Tj EMC (\006\036\035\034\033 )Tj 0.141 Tw T* (\007\036\022\024\n\023\030\036\f\f\017\017 \r\t\023\024\035\027\016\035\017\ \r)Tj /Span<>> BDC ( )Tj EMC (40,8% \f\035\031\004\026\036\r \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031)Tj 0 Tw (-)Tj 0.165 Tw T* (\021\030\017\002\030\033\001\017\027\027\t\b \217\215\025 \017)Tj /Span<>> BDC ( )Tj EMC (\r 23,8% \022\035\017\027\017\004\036\f\022\017\b \027\026\002\035\033)Tj 0 Tw (-)Tj 0.114 Tw T* (\007\036\027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC 4.723 0 Td [(\r\027\036\002\030\033\001\017\027\027\t\b )0.5(\217\215\025. )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (9,5% \027\026\002\035\033\007\036\027\017\005 )Tj 0.042 Tw -4.723 -1.218 Td (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\b\ \007\024\023\024\035\027\017\021\036\035\034\027\024 \031\001\017\r\026\ )Tj 0 Tw (-)Tj -0.046 Tw 0 -1.218 TD [(\035\017 \030\026\027\t \n\024\004\036\r\024\020\024 \023\031\t\030\016\ . )0.5(\200)]TJ /Span<>> BDC ( )Tj EMC (36,5% \f\035\031\004\026\036\r \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023)Tj 0 Tw (-)Tj 0.129 Tw 0 -1.218 TD (\023\036 \017)Tj /Span<>> BDC ( )Tj EMC (\r 33,3% \027\026\002\035\033\007\036\027\017\005 \r\024 2-\005 \020\030\ \031\023\023\036 \r\t\023\024\035\027\016\035\017 )Tj 0.056 Tw 0 -1.218 TD (\023\030\024\004\017\036 \024\023\036\030\026\006\017\017, \027\026\023\030\ \016\n\031\033 \027\036 \f\r\016\026\027\027\t\036 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017)Tj 0 Tw (-)Tj 0.012 Tw T* (\036\n \023\030\016\n\024\005 \022\017\001\022\017. \205\024\030\n\017\030\ \024\r\026\027\017\036 \020\027\024\005\027\t\b \026\002\f\006\036\f\f\024\ \r )Tj 0.133 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.883 0 Td [(\235\035\036\020\n\024\027\t )0.5(\021\026\026 )0.6(\r)]TJ /Span<>> BDC ( )Tj EMC 7.479 0 Td [(\024\f\027\024\r\027\024\005 )0.6(\020\030\031\023\023\036 )0.5(\027\036 )0.5(\026\030\036\020\017\f\021\030\017)]TJ 0 Tw (-)Tj 0.028 Tw -8.363 -1.218 Td (\030\024\r\026\027\t. \200)Tj /Span<>> BDC ( )Tj EMC (\020\030\031\023\023\036 \f\030\026\r\027\036\027\017\016 \017\n\036\035\ \017 \n\036\f\021\024 \020\027\024\005\027\024-\027\036)Tj 0 Tw (-)Tj 0.125 Tw T* [(\022\030\024\021\017\004\036\f\022\017\036 )0.5(\017\n\036\027\036\027\017\016 )0.5(\025\215\221, \024\021\n\036\004\036\027\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC (2-\036 \f\031\021\022\017 )Tj -0.024 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC 0.683 0 Td [(12,5% )0.5(\027\026\002\035\033\007\036\027\017\016\b, )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 9.766 0 Td [(3-\036 )0.5(\f\031\021\022\017 \017)]TJ /Span<>> BDC ( )Tj EMC 4.704 0 Td (\002\024\035\036\036)Tj /Span<>> BDC ( )Tj EMC 2.624 0 Td [(\227 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC (62,5% )Tj 0 Tw -17.775 -1.218 Td (\f\035\031\004\026\036\r.)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 444.7358 Tm [(\020)21(\026\027\r\241\225\034\022\031\034)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.28 Tw 10 0 0 10 42.5197 420.3798 Tm [(\217\036\031\035\034\021\026\021\t )0.6(\023\030\024\r\036\007\201\027\027\024\020\024 )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 )0.6(\023\024\r\024\035\016\033\021 )]TJ 0.129 Tw T* [(\027\026\020\035\016\007\027\024 )0.6(\023\030\024\007\036\n\024\027\f\021\030\017\030\024\r\026\021\034 )0.6(\f\024\r\030\036\n\036\027\027\t\036 )0.5(\007\026\027\027\t\036 )]TJ 0.245 Tw T* (\024)Tj /Span<>> BDC ( )Tj EMC (\b\026\030\026\022\021\036\030\017\f\021\017\022\026\b \217\215\025, \024\ \002\255\201\n\036 \024\022\026\026\027\017\016 \b\017\030\031\030\020\017\ )Tj 0 Tw (-)Tj 0.124 Tw T* [(\004\036\f\022\024\005 )0.5(\023\024\n\024\013\017 \027\026)]TJ /Span<>> BDC ( )Tj EMC 8.164 0 Td [(\233\204\233, )0.5(\026)]TJ /Span<>> BDC ( )Tj EMC [(\021\026\022\032\036 )0.5(\f\030\024\022\026\b \017)]TJ /Span<>> BDC ( )Tj EMC 9.798 0 Td (\b\026\030\026\022\021\036\030\036 )Tj 0.227 Tw -17.961 -1.218 Td (\017\n\036\r\001\017\b \n\036\f\021\024 \024\f\035\024\032\027\036\027\017\ \005. \222\017\f\021\036\n\026\021\017\026\006\017\016 \023\024\035\031\ )Tj 0 Tw (-)Tj 0.341 Tw T* [(\004\036\027\027\t\b \030\036\031\035\034\021\026\021\024\r )0.5(\017\f\f\035\036\007\024\r\026\027\017\016 \023\024\r\024\035\017\035\026\ )0.5(\030\026)]TJ 0 Tw (-)Tj 0.257 Tw T* (\030\026\002\024\021\026\021\034 \007\017\235\235\036\030\036\027\006\017\ \030\024\r\026\027\027\t\005 \026\035\020\024\030\017\021\n \024\022\026\ \026\027\017\016 )Tj 0.078 Tw T* (\b\017\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017 \ \027\026)Tj /Span<>> BDC ( )Tj EMC (\233\204\233, \023\024\r\024\035\016\033\013\017\005 \030\036\020\035\026\ )Tj 0 Tw (-)Tj 0.045 Tw T* (\n\036\027\021\017\030\024\r\026\021\034 \027\036 \021\024\035\034\022\024\ \024\002\255\201\n \024\023\036\030\026\021\017\r\027\024\020\024 \035\036\ \004\036\027\017\016, )Tj 0 Tw T* (\027\024 \017)Tj /Span<>> BDC ( )Tj EMC (\023\024\022\026\026\027\017\016 \022)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\033 \025\215\221.)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (\222\030\032\255\020\034\036 \032\026\020\017\022\017\026)Tj /T1_1 1 Tf 0.616 Tw 0 -1.218 TD [(\025)-4.1(\024)-4.3(\027)1.7(\006)-6(\036)-6.8(\023)2.2(\006)-6(\017)-5.4(\016 \017)]TJ /Span<>> BDC ( )Tj EMC [(\007)-6(\017)2.8()-9.9(\026\005)1.7(\027 \017)-2.4(\f)3.1(\f)-38.9(\035)-6.7(\036)-19(\007)-4.4(\024)-4.3(\r)-8.9(\026\027)1.7(\017)-5.5(\016)13.7(:)]TJ /T1_4 1 Tf -0.027 Tc 0.643 Tw [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 19.17 0 Td ( )Tj EMC [(\002)1.9(.)0.5(\224.)-19.2(,)-27( )]TJ -0.01 Tc 0.01 Tw -19.17 -1.218 Td [(\215)-1.6(\r)-3.4(\024\020)-5.5(\022)-12.3(\f)-6.7(\031\021)]TJ /Span<>> BDC 3.837 0 Td ( )Tj EMC [(\211)14.3(.)-2.7(\003)-12.2(.)-2.2(,)-10( \003)9.9(\240)-8.5(\030)-13.8(\r)-14.3(\032)-7(\020)-24.3(\200)-11.9(\026)-3.1(\020)-5.7(\025)-6.2(\031\021)]TJ /Span<>> BDC 8.093 0 Td ( )Tj EMC [(\206)83.9(.)66.5(\214)44.8(.)]TJ /T1_1 1 Tf 0 Tc 1.042 Tw -11.93 -1.218 Td [(\222)-4.6(\002)-9.9(\024)0.7(\030 \017)]TJ /Span<>> BDC ( )Tj EMC [(\024)-11.8(\002)3(\030)-11.4(\026)-6.3(\002)-9.9(\024)-10.9(\021)-17.7(\022)-19.1(\026 \n)1.3(\026)-11.8(\021)-9.9(\036)-1.7(\030)-7.6(\017)-0.6(\026)-33.1(\035)-2.4(\024)-4.3(\r)10.3(:)]TJ /T1_4 1 Tf -0.027 Tc 1.069 Tw [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 18.744 0 Td ( )Tj EMC [(\002)1.8(.)0.5(\224.)-19.1(,)-27( )]TJ -0.004 Tc 0.004 Tw -18.744 -1.218 Td [(\003)15.9(\240)-2.5(\030)-7.8(\r)-8.3(\032)-1(\020)-18.4(\200)-5.8(\026)2.9(\020\025\031)5.6(\021)]TJ /Span<>> BDC 5.79 0 Td ( )Tj EMC [(\206)89.9(.)72.5(\214)50.8(.)]TJ /T1_1 1 Tf 0.018 Tc 2.182 Tw -5.79 -1.218 Td [(\222)35.2(\021)-3.5(\026)6.2(\021\017)15.6(\f)-18(\021\017)22.5(\004)9.8(\036)7.6(\f)16.4(\022)-1.1(\026)-3(\016)18( \024)6.2(\002)21(\030)6.6(\026)11.7(\002)8.1(\024)7.1(\021\022)-1.1(\026)21.8(:)]TJ /T1_4 1 Tf -0.027 Tc 2.227 Tw 13.549 0 Td [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 4.037 0 Td ( )Tj EMC [(\002)1.8(.)0.5(\224.)-19.1(,)-27( )]TJ -0.004 Tc 0.004 Tw -17.586 -1.218 Td [(\003)15.9(\240)-2.5(\030)-7.8(\r)-8.3(\032)-1(\020)-18.4(\200)-5.8(\026)2.9(\020\025\031)5.6(\021)]TJ /Span<>> BDC 5.79 0 Td ( )Tj EMC [(\206)89.9(.)72.5(\214)50.8(.)]TJ /T1_1 1 Tf 0.002 Tc -0.002 Tw -5.79 -1.218 Td [(\203)7.2(\026\023)4.2(\017\f)-10.8(\026)1.7(\027)3.7(\017)-6.7(\036)2.1( \021)-7.9(\036)-3.4(\022\f)-34(\021)-19.5(\026)5.7(:)]TJ /T1_4 1 Tf -0.027 Tc 0.027 Tw 7.694 0 Td [( \202)-10.4(\022)-22.4(\026)]TJ /Span<>> BDC 1.838 0 Td ( )Tj EMC [(\002)1.8(.)0.5(\224.)]TJ /T1_1 1 Tf 0 Tc 0 Tw -9.531 -1.218 Td [(\217)5.5(\036)-19(\007)-20.1(\026\022)-32.6(\021)-17.7(\017)1.5(\030)-11.8(\024)-4.4(\r)-8.8(\026\027)1.8(\017)-8.7(\036)6.5(:)]TJ /T1_4 1 Tf -0.01 Tc 0.01 Tw [( \215)-1.6(\r)-3.4(\024\020)-5.5(\022)-12.3(\f)-6.7(\031\021)]TJ /Span<>> BDC 11.204 0 Td ( )Tj EMC [(\211)14.3(.)-2.7(\003)-12.2(.)]TJ /T1_3 1 Tf 0 Tc 0.023 Tw 12.04 53.583 Td (AUTHORS CONTRIBUTION)Tj /T1_1 1 Tf 0.451 Tw 0 -1.218 TD [(C)-6.5(o)0.8(nce)-0.7(p)-12.3(t a)2.4(n)-4.6(d d)-5.5(e)-13.3(s)-16.6(i)3.2(g)1.2(n o)-2.3(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e s)-20(t)-12.8(ud)-10.9(y)-11.8(:)]TJ /T1_4 1 Tf [( I)10(g)-2.5(o)1.4(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)11(i)8.4(m)-6.5(, )]TJ 0 Tw 0 -1.218 TD [(V)-5.5(i)0.9(t)2.3(all)11.1(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(us)7.8(a)-2(i)7.5(l)2.9(o)-0.6(v)33.6(, R)-4.1(i)8.4(n)4.8(a)-4.9(t F)65.2(.)]TJ /Span<>> BDC ( )Tj EMC [(A)6(b)-5.9(d)5.2(u)6.1(r)7.7(a)1.7(k)5.3(h)5.3(m)4.3(a)-0.8(n)1.9(o)-0.6(v)]TJ /T1_1 1 Tf -0.013 Tw 0 -1.218 TD [(C)-6.5(o)-5.8(l)-19(l)-14.3(e)-9.4(c)-32.5(t)-37.3(i)3.2(o)0.8(n a)2.4(n)-4.6(d p)-3.8(r)-6(o)-7(ce)-13.2(s)-12.9(s)-16.5(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.6(h)-5.3(e m)1.9(a)-8.4(t)-15.2(e)-2.1(r)-48(i)5.1(a)-1.5(l)-22.5(:)]TJ /T1_4 1 Tf [( I)10(g)-2.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC [(Y)33.7(u)7.7(. K)10.9(i)8.4(m)-6.4(, )]TJ -0.005 Tc 0.005 Tw 0 -1.218 TD [(R)-9.1(i)3.4(na)-9.9(t)-5( F)60.2(.)]TJ /Span<>> BDC 3.01 0 Td ( )Tj EMC [(A)1(b)-10.9(du)1.1(r)2.7(a)-3.2(khm)-0.7(a)-5.8(n)-3.1(o)-5.6(v)]TJ /T1_1 1 Tf -0.007 Tc 1.114 Tw -3.01 -1.218 Td [(St)-34.7(a)-15.4(t)-44.4(i)-4.3(s)-27(t)-44.4(i)-1.8(c)-18.8(a)-8.5(l)-7( )0.6(p)-10.8(r)-13(o)-14(c)-6.8(e)-20.3(s)-19.8(s)-23.6(in)-8.9(g)2(:)]TJ /T1_4 1 Tf 0 Tc 1.107 Tw 10.195 0 Td [( )0.5(I)10(g)-2.5(o)1.3(r)]TJ /Span<>> BDC ( )Tj EMC 4.275 0 Td [(Y)33.7(u)7.7(. )0.6(K)10.9(i)8.4(m)-6.5(, )0.5(R)-4.1(i)8.4(n)4.9(a)-4.9(t )]TJ -0.005 Tc 0.005 Tw -14.47 -1.218 Td [(F)60.2(.)]TJ /Span<>> BDC 0.692 0 Td ( )Tj EMC [(A)1(b)-10.9(du)1.1(r)2.7(a)-3.2(khm)-0.7(a)-5.8(n)-3.1(o)-5.6(v)]TJ /T1_1 1 Tf 0 Tc 0 Tw -0.692 -1.218 Td [(W)3.1(r)-48(i)-6(t)-37.4(i)7.1(n)-1.9(g o)-2.2(f)]TJ /Span<>> BDC ( )Tj EMC [(t)-16.7(h)-5.3(e t)-15.2(e)-23.9(x)-36(t)-20(:)]TJ /T1_4 1 Tf -0.008 Tc 0.008 Tw [( I)2(g)-10.5(o)-6.7(r)]TJ /Span<>> BDC 9.742 0 Td ( )Tj EMC [(Y)25.7(u.)-8( K)2.9(im)]TJ /T1_1 1 Tf 0.006 Tc -0.006 Tw -9.742 -1.218 Td [(E)11.6(dit)-31.4(i)13.1(n)4.1(g)15(:)]TJ /T1_4 1 Tf 0 Tc 0 Tw 3.238 0 Td [( V)-5.5(i)0.9(t)2.3(all)11(y)]TJ /Span<>> BDC ( )Tj EMC [(A)-12.6(.)]TJ /Span<>> BDC ( )Tj EMC [(M)5.6(us)7.9(a)-2(i)7.4(l)2.9(o)-0.6(v)]TJ /T1_3 1 Tf 0.023 Tw -3.238 -2.436 Td (\255\026\036\031\036\025\034\223 \017\224 \032\026\020\017\022\032\225 \(\ ORCID\))Tj /T1_1 1 Tf 0.006 Tc 0.424 Tw 0 -1.218 TD (\025\017\n \230\020\024\030\034 \224\030\034\036\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \f\021\026\030\001\017\005 \024\030\007\017\027\026\021\024\030 \b\017\ )Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.645 Tw T* [(\030\031\030\020\017\004\036\f\022\024\020\024 \024\021\007\036\035\036\027\ \017\016 \(\027\036\024\021\035\024\032\027\024\005 \b\017\030\031\030\020\ \017\017,)6( )]TJ 0.11 Tw T* (\027\026)Tj /Span<>> BDC ( )Tj EMC (20 \022\024\036\022\) \235\017\035\017\026\035\026 \2231 \205\206\207\211\ \253\203\204\230\037 \r\t\f\024\022\017\b \n\036)Tj 0 Tc 0 Tw (-)Tj 0.006 Tc 0.463 Tw T* (\007\017\006\017\027\f\022\017\b \021\036\b\027\024\035\024\020\017\005)Tj /Span<>> BDC ( )Tj EMC [(\227 \006\036\027\021\030\026\035\034\027\t\005 \r\024\036\027\027\t\005\ )6( )]TJ 0.314 Tw T* (\022\035\017\027\017\004\036\f\022\017\005 \020\024\f\023\017\021\026\035\ \034 \017\n\036\027\017 \202.\202.)Tj /Span<>> BDC ( )Tj EMC [(\200\017\001\027\036\r\f\022\024\020\024\273)6( )]TJ 0.686 Tw T* [(\204\017\027\017\f\021\036\030\f\021\r\026 )0.6(\024\002\024\030\024\027\t )0.6(\217\024\f\f\017\005\f\022\024\005 )0.5(\205\036\007\036\030\026\006\017\017;)6( )]TJ 0.279 Tw T* [(ORCID 0009-0004-4515-2275, SPIN-\022\024\007: 5081-5918,)6( )]TJ 0 Tw T* [(A)10(ut)-13(hor ID: 854679)]TJ 0 Tc 0.295 Tw T* [(\204\031\f\026\017\035\024\r )0.5(\200\017\021\026\035\017\005 )0.6(\202\027\026\021\024\035\034\036\r\017\004)]TJ /Span<>> BDC ( )Tj EMC 14.231 0 Td [(\227 )0.5(\007.\n.\027., )0.5(\027\026\004\026\035\034)]TJ 0 Tw (-)Tj 0.352 Tw -14.231 -1.218 Td [(\027\017\022 \b\017\030\031\030\020\017\004\036\f\022\024\020\024 )0.5(\024\021\007\036\035\036\027\017\016 \(\f \024\023\036\030\026\006\017\024\ \027\027\t\n\017 )]TJ 0.413 Tw T* (\002\035\024\022\026\n\017 \017)Tj /Span<>> BDC ( )Tj EMC [(\006\036\027\021\030\026\035\034\027\024\005 \f\021\036\030\017\035\017\ \026\006\017\024\027\027\024\005\) )0.5(\205\206\207\211 )]TJ 0.307 Tw T* (\253\203\204\230\037 \r\t\f\024\022\017\b \n\036\007\017\006\017\027\f\022\ \017\b \021\036\b\027\024\035\024\020\017\005)Tj /Span<>> BDC ( )Tj EMC (\227 \006\036\027)Tj 0 Tw (-)Tj 0.583 Tw T* [(\021\030\026\035\034\027\t\005 \r\024\036\027\027\t\005 \022\035\017\027\ \017\004\036\f\022\017\005 )0.5(\020\024\f\023\017\021\026\035\034 \017\n\036)]TJ 0 Tw (-)Tj 0.782 Tw T* (\027\017 \202.\202.)Tj /Span<>> BDC ( )Tj EMC (\200\017\001\027\036\r\f\022\024\020\024\273 \204\017\027\017\f\021\036\030\ \f\021\r\026 \024\002\024\030\024\027\t )Tj 0.118 Tw T* (\217\024\f\f\017\005\f\022\024\005 \205\036\007\036\030\026\006\017\017,\ \023\030\036\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\ \030\t \b\017)Tj 0 Tw (-)Tj 0.062 Tw T* (\030\031\030\020\017\017 \(\f \022\031\030\f\024\n \024\027\022\024\035\024\ \020\017\017 \017)Tj /Span<>> BDC ( )Tj EMC (\035\031\004\036\r\024\005 \007\017\026\020\027\024\f\021\017\022\017\) \ )Tj 0.024 Tw T* (\235\017\035\017\026\035\026 \235\036\007\036\030\026\035\034\027\024\020\ \024 \020\024\f\031\007\026\030\f\021\r\036\027\027\024\020\024 \002\033\ \007\032\036\021\027\024)Tj 0 Tw (-)Tj 0.115 Tw T* [(\020\024 \r\024\036\027\027\024\020\024 \024\002\030\026\024\r\026\021\036\ \035\034\027\024\020\024 )0.5(\031\004\030\036\032\007\036\027\017\016 )0.5(\r\t\f\001\036\020\024 )]TJ 0.498 Tw T* [(\024\002\030\026\024\r\026\027\017\016 )0.6(\253\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\026\016 )0.6(\026\022\026\007\036\n\017\016 )0.5(\017\n. )]TJ 0.25 Tw T* (\222.\204.)Tj /Span<>> BDC ( )Tj EMC 2.209 0 Td [(\025\017\030\024\r\026\273 )0.5(\r)]TJ /Span<>> BDC ( )Tj EMC [(\020. )0.5(\204\024\f\022\r\036; ORCID )0.5(0000-0002-0168-)]TJ 0.637 Tw -2.209 -1.218 Td [(0939, eLIBRAR)-13.9(Y SPIN-\022\024\007: 3379-0023, eLIBRAR)-13.9(Y )]TJ 0 Tw T* [(A)10(ut)-13(hor ID: 856312)]TJ 0.191 Tw T* (\202\002\007\031\030\026\b\n\026\027\024\r \217\017\027\026\021 \205\026\ \030\017\007\024\r\017\004)Tj /Span<>> BDC ( )Tj EMC (\227 \022.\n.\027., \f\021\026\030\001\017\005 )Tj 0.211 Tw T* [(\023\030\036\023\024\007\026\r\026\021\036\035\034 \022\026\235\036\007\030\ \t )0.5(\(\b\017\030\031\030\020\017\017 \027\036\024\021\035\024\032\027\t\b \f\ \024)]TJ 0 Tw (-)Tj 0.303 Tw T* (\f\021\024\016\027\017\005\) \235\017\035\017\026\035\026 \235\036\007\036\ \030\026\035\034\027\024\020\024 \020\024\f\031\007\026\030\f\021\r\036\027\ \027\024\020\024 )Tj 0.394 Tw T* (\002\033\007\032\036\021\027\024\020\024 \r\024\036\027\027\024\020\024 \ \024\002\030\026\024\r\026\021\036\035\034\027\024\020\024 \031\004\030\ \036\032\007\036)Tj 0 Tw (-)Tj 0.584 Tw T* (\027\017\016 \r\t\f\001\036\020\024 \024\002\030\026\024\r\026\027\017\016\ \253\200\024\036\027\027\024-\n\036\007\017\006\017\027\f\022\026\016 )Tj 0.435 Tw T* (\026\022\026\007\036\n\017\016 \017\n. \222.\204.)Tj /Span<>> BDC ( )Tj EMC (\025\017\030\024\r\026\273 \204\017\027\024\002\024\030\024\027\t \217\024\ \f\f\017\017 )Tj 0 Tw T* (\r)Tj /Span<>> BDC ( )Tj EMC (\020.)Tj /Span<>> BDC ( )Tj EMC (\204\024\f\022\r\036; ORCID 0000-0001-7037-943\216)Tj /T1_3 1 Tf 0.023 Tw 0 -2.436 TD (INFORMATION ABOUT THE)Tj /Span<>> BDC ( )Tj EMC (AUTHORS \(ORCID\))Tj /T1_1 1 Tf 0 Tw 0 -1.218 TD [(Igor Y)35(u. Kim)]TJ /Span<>> BDC ( )Tj EMC (\227 0009-0004-4515-2275)Tj T* [(V)-15(i)-24(t)15(all)35(y A. Musail)30.1(ov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0002-0168-0939)Tj T* [(R)-24(ina)15(t F. A)-13.9(bdur)-33(akhmanov)]TJ /Span<>> BDC ( )Tj EMC (\227 0000-0001-7037-943\216)Tj 1 0.68 0 0.12 k /GS0 gs /T1_2 1 Tf 0.01 Tc -0.01 Tw 14 0 0 14 42.5896 152.4639 Tm [(\r\031\024\034\033)48(\026)45(\024)-10(\224\033)48(\026/REFERENCES)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0 Tc 0.224 Tw 8 0 0 8 42.5197 139.6292 Tm (1.)Tj /Span<>> BDC ( )Tj EMC 1.296 0 Td (\025\026\035\026\004\036\r)Tj /Span<>> BDC ( )Tj EMC (\210.\200., \215\026\023\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\202.\224., \221\024\022\n\026\022\024\r)Tj /Span<>> BDC ( )Tj EMC (\204.\202., \017)Tj /Span<>> BDC ( )Tj EMC (\f\024\026\r\021. \210)Tj /Span<>> BDC ( )Tj EMC (\027\036\024\002)Tj 0 Tw (-)Tj 0.01 Tc 0.384 Tw -1.296 -1.25 Td [(\b\024\007\017\n\024\f\021\017 )0.5(\023\030\036\024\002\030\026\024\r\026\027\017\016 )0.5(\f\017\f\021\036\n\t )0.5(\n\036\007\017\006\017\027\f\022\024\020\024 )0.5(\024\002\036\f\023\036\004\036)]TJ 0 Tc 0 Tw (-)Tj 0.256 Tw 0 -1.25 TD (\027\017\016 \r\024\005\f\022 \(\f\017\035\) \r)Tj /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\t\b \031\f\035\024\r\017\016\b. )Tj /T1_4 1 Tf 0 Tw (\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 )Tj T* (\255\r\032\025\020\f)Tj /T1_1 1 Tf 0.196 Tw [(. 2024;345\(2\):4\2268. d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.52424/00269050_2024_345_2_)Tj T* (4)Tj 0 0 0 1 k /GS1 gs 0.097 Tw [( / K)-16(al)-16(a)-17(chev)]TJ /Span<>> BDC ( )Tj EMC [(O.V., P)39.9(apkov)]TJ /Span<>> BDC ( )Tj EMC [(A.Y)35.1(u., T)45(okmakov)]TJ /Span<>> BDC ( )Tj EMC [(M.A., e)-12(t)]TJ /Span<>> BDC ( )Tj EMC [(al. On t)-13(he)]TJ /Span<>> BDC ( )Tj EMC (need )Tj 0.299 Tw T* [(t)17(o)]TJ /Span<>> BDC ( )Tj EMC 1.366 0 Td [(tr)-33(ansfor)-15.9(m )0.5(t)-13(he)]TJ /Span<>> BDC ( )Tj EMC 6.352 0 Td [(medical )0.6(suppor)-22(t )0.5(sy)-12.9(stem )0.5(for )0.6(tr)-32(o)-16(ops )0.6(\(for)-32(ces\) )0.6(in )]TJ 0.159 Tw -7.718 -1.25 Td [(moder)-15(n condi)-24(t)-32(ions. )]TJ /T1_4 1 Tf [(Militar)-42.9(y Medical Jour)-13.9(nal.)]TJ /T1_1 1 Tf ( 2024;345\(2\):4\2268. \(in )Tj 0.023 Tw 29.055 7.5 Td [(Russ.\). d)-16(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 0 Tw (10.52424/00269050_2024_345_2_4)Tj 0 0 0 1 k /GS1 gs 0.013 Tc 0.469 Tw T* (2.)Tj /Span<>> BDC ( )Tj EMC 1.334 0 Td (\025\026\f\017\n\024\r)Tj /Span<>> BDC ( )Tj EMC (\217.\217., \210\r\004\026\030\024\r)Tj /Span<>> BDC ( )Tj EMC (\210.\204., \222\026\n\024\b\r\026\035\024\r)Tj /Span<>> BDC ( )Tj EMC (\230.\204., \017)Tj /Span<>> BDC ( )Tj EMC [(\f\024\026\r\021.)13( )]TJ 0 Tc 0.034 Tw -1.334 -1.25 Td [(\222\023\036\006\017\026\035\017\017\030\024\r\026\027\027\026\016 )0.5(\b\017\030\031\030\020\017\004\036\f\022\026\016 )0.5(\023\024\n\024\013\034 \r)]TJ /Span<>> BDC ( )Tj EMC (\f\024\r\030\036\n\036\027\027\024\n \r\024\036\027)Tj 0 Tw (-)Tj 0.324 Tw T* (\027\024\n \022\024\027\235\035\017\022\021\036: \030\024\035\034 \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\f\021\024 \027\026)Tj /Span<>> BDC ( )Tj EMC (\023\036\030\036\007\024\r\t\b \220\021\026\023\026\b \n\036\007\017\006\ \017\027)Tj 0 Tw (-)Tj 0.143 Tw T* (\f\022\024\005 \220\r\026\022\031\026\006\017\017. )Tj /T1_4 1 Tf (\211\031\027\025\025\031-\026\027\030\022\006\022\025\024\n\022\235 \255\ \r\032\025\020\f)Tj /T1_1 1 Tf (. 2024;345\(2\):9\22618. )Tj 0 Tw 27.638 0 Td ( )Tj 0.025 Tc -0.025 Tw -27.638 -1.25 Td [(d)-15.6(oi:)]TJ /Span<>> BDC ( )Tj EMC 1 0.68 0 0.12 k /GS0 gs 2.832 0 Td (10.52424/00269050_2024_345_2_9)Tj 0 0 0 1 k /GS1 gs 0.885 Tw [( / K)-15.7(asimov)]TJ /Span<>> BDC ( )Tj EMC [(R.R.,)25( )]TJ 0 Tc -0.163 Tw -2.832 -1.25 Td [(O)-23.6(vchar)-31.6(ov)]TJ /Span<>> BDC 3.731 0 Td ( )Tj EMC 0.07 0 Td [(O.M., )0.5(Samok)0.5(hv)-14.6(al)30.4(ov)]TJ /Span<>> BDC ( )Tj EMC 7.341 0 Td [(I.M., )0.5(e)-11.5(t)]TJ /Span<>> BDC ( )Tj EMC 2.785 0 Td [(al. )0.5(Spec)-23.5(ial)-30.6(ized )0.5(sur)-31.6(gica)0.5(l )0.5(car)-23.6(e )0.5(in )0.5(mod)]TJ 0 Tw (-)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.8268 56.0378 Tm (63)Tj ET endstream endobj 1347 0 obj <>/Border[0 0 0]/H/N/Rect[149.71 116.925 263.622 107.469]/Subtype/Link/Type/Annot>> endobj 1348 0 obj <>/Border[0 0 0]/H/N/Rect[42.5197 106.925 46.5197 97.6292]/Subtype/Link/Type/Annot>> endobj 1349 0 obj <>/Border[0 0 0]/H/N/Rect[314.069 146.925 431.98 137.629]/Subtype/Link/Type/Annot>> endobj 1350 0 obj <>/Border[0 0 0]/H/N/Rect[297.619 96.9252 421.44 87.6292]/Subtype/Link/Type/Annot>> endobj 1354 0 obj <> endobj 1353 0 obj <> endobj 1352 0 obj <> endobj 1351 0 obj <> endobj 1322 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 0 0 0 1 k /GS1 gs /T1_0 1 Tf 0.121 Tw 10 0 0 10 70.8661 456.9139 Tm (\024\002\255\016\f\027\017\021\034 \026\027\026\021\024\n\024-\021\024\023\ \024\020\030\026\235\017\004\036\f\022\017\n\017 \024\f\024\002\036\027\027\ \024\f\021\016)Tj 0 Tw (-)Tj 0.331 Tw 0 -1.218 TD (\n\017 \030\026\f\023\024\035\024\032\036\027\017\016 \r\027\036\002\030\ \033\001\017\027\027\t\b \024\021\007\036\035\024\r \023\030\016\n\024\005\ )Tj 0.076 Tw T* (\022\017\001\022\017, \007\036\235\017\006\017\021\024\n \024\023\t\021\027\ \t\b \f\023\036\006\017\026\035\017\f\021\024\r \017)Tj /Span<>> BDC ( )Tj EMC (\n\036\007\017\022\024-)Tj 0.056 Tw T* (\021\026\022\021\017\004\036\f\022\024\005 \024\002\f\021\026\027\024\r\022\ \024\005. \205\024\030\n\017\030\024\r\026\027\017\036 \024\021\r\024\007\ \016\013\036\005 )Tj 0.131 Tw T* [(\022\024\035\024\f\021\024\n\t )0.5(\027\026)]TJ /Span<>> BDC ( )Tj EMC 6.141 0 Td [(\023\036\030\036\007\027\033\033 )0.6(\002\030\033\001\027\031\033 )0.5(\f\021\036\027\022\031 )0.5(\r\t\023\024\035\027\016)]TJ 0 Tw (-)Tj 0.172 Tw -6.141 -1.218 Td (\035\017 \027\026)Tj /Span<>> BDC ( )Tj EMC (25,9% \004\026\013\036 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031\021\030\017\002\030\033\001\017\027\027\t\b \030\026\027\036\027\ \017\016\b )Tj 0.034 Tw T* (\(80,6%\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\024\021\027\024\001\036\027\017\033 \022)Tj /Span<>> BDC ( )Tj EMC (\023\026\006\017\036\027\021\026\n \f)Tj /Span<>> BDC ( )Tj EMC (\r\027\036\002\030\033\001\017\027\027\t)Tj 0 Tw (-)Tj T* (\n\017 \217\215\025 \(54,7%\).)Tj 0.115 Tw T* [(\215\030\017 \030\036\021\030\024\f\023\036\022\021\017\r\027\024\n \026\ \027\026\035\017\036 )0.5(\030\036\031\035\034\021\026\021\024\r \b\017\030\031\030\020\017)]TJ 0 Tw (-)Tj -0.036 Tw T* (\004\036\f\022\024\020\024 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M2!8^9 ISf9;Sk4~"!֛6J&N7.G|qpGhijoB{ڞΑW>uiKqD6܄DT`SPyI-4e~̮b:jTWY0Q:Z cÅ&ffy97ДJy4NL'PkiIijNJ5FNcS :)Be)Bj{ŸXeu=ԙm*T}դ)32qtvR$)`ub2"Bd>=R✦R^ʄ%DJJ$\wS3g݊6Ҷ%鲛ZG#<ۧt+I$F[KFD]]2$|qRm 6FCSrڐ#Q`̭R85P8nˊrTK$2=t쮉P$ʚfa;7&Qik$ZRk,9XȨ:E˞#a6v[lX_rUKǟ.dnJa6)3xI 7EA:gFPTk4yv=ͻܹ=R9CDbM)٨tc>^Oj~9]ɴj[&H-ݵ"VF>ɠR%#a BdxRdi%YE+3j7 ;2YmqܪE5D8$ۛc'7ws ,Ji$66jI3Gc2ɪuJTdIddOUԑ&ýkh#)~"Q&~TdwrnMp݇-FjZ)VJR7!M9EmQ1ٙL?`t':"+,ƲF,N 5aYѕҭ{tuӨQ0M)"RKqfEJ;zW8Zrа#&sc)Z^#L="#i/RԄII܄it RBĞRtқ$sRuٲvyjGDdm$B6#3I gw>stream endstream endobj 1355 0 obj <>stream endstream endobj 1318 0 obj <>stream q /GS0 gs /Fm0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 42.7216 Tm [(\201\n\216\216\004\005\004\t\n\005\025\b\017\t\t\217\221 \017\020\013)10(\025\005\n\026\024 \025\r\017\212\017\t\n\213 \220\n\005\002\005\013\n\225\ \004\016\r)10(\025\221 \224\025\024\025\234\n )]TJ 0 -1 TD [(\224\005\n\022\005\017\t\004\t\n\213\220 \224\005\213\024\025\221 \r\n\204\ \r\n \t\017\022\237\026)11(\017\224\017\220 \024\004\202\n\n\t\016\r)10(\025\221 \237\b\017\r\002\017\n\n)]TJ 39.559 1 Td [(A dif)-30.9(fer)31(entiated algorithm for pr)20(oviding sur)31(gical car)31(e )]TJ 0.177 -1 Td [(for\022r)31.1(ectal injuries at th)10.9(e\022stages of\022medical e)11(v)10(acuation)]TJ 0 0 0 1 k /GS1 gs /T1_1 1 Tf 0.211 Tw 10 0 0 10 42.5197 615.2279 Tm (\n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\017 \024\023\ \036\030\026\006\017\005 \023\024)Tj /Span<>> BDC ( )Tj EMC (\032\017\027\036\027\027\t\n \023\024)Tj 0 Tw (-)Tj 0.354 Tw 0 -1.218 TD (\022\026\026\027\017\016\n. \215\030\017)Tj /Span<>> BDC ( )Tj EMC (\220\021\024\n \023\024\022\026\026\027\017\036\n \022)Tj /Span<>> BDC ( )Tj EMC (\007\030\036\027\017\030\024\r\026\027\017\033 )Tj 0.836 Tw T* (\023\030\036\f\026\022\030\026\035\034\027\024\020\024 \023\030\024\f\021\ \030\026\027\f\021\r\026 \007\024\035\032\027\024 \016\r\035\016\021\034\ \f\016 )Tj 0.722 Tw 0 -1.218 TD (\027\026\035\017\004\017\036 \020\027\024\005\027\024-\027\036\022\030\024\ \021\017\004\036\f\022\017\b \017\n\036\027\036\027\017\005 \025\215\221\ . )Tj 0.147 Tw 0 -1.218 TD (\215\030\036\r\036\027\021\017\r\027\024\036 \007\030\036\027\017\030\024\ \r\026\027\017\036 \025\215\221 \023\024\022\026\026\027\024 \023\030\017\ )Tj /Span<>> BDC ( )Tj EMC (\r\t)Tj 0 Tw (-)Tj 0 -1.218 TD (\f\024\022\017\b \026\n\023\031\035\016\030\027\t\b \030\026\027\036\027\ \017\016\b.)Tj 0.129 Tw T* (\215\030\017 \027\017\022\017\b \030\026\027\036\027\017\016\b \023\030\ \016\n\024\005 \022\017\001\022\017, \007\024\f\021\031\023\027\t\b \r\017\ )Tj 0 Tw (-)Tj 0.256 Tw T* (\031\026\035\034\027\024\n\031 \022\024\027\021\030\024\035\033 \023\024\ \r\030\036\032\007\036\027\017\005, \007\024\f\021\026\021\024\004\027\024\ \r\t)Tj 0 Tw (-)Tj 0.185 Tw T* (\023\024\035\027\036\027\017\016 \023\036\030\r\017\004\027\024\005 \b\017\ \030\031\030\020\017\004\036\f\022\024\005 \024\002\030\026\002\024\021\022\ \017, \004\021\024 )Tj 0.552 Tw 23.244 9.742 Td (\f\024\r\023\026\007\026\036\021 \f)Tj /Span<>> BDC ( )Tj EMC [(\002\024\035\034\001\017\027\f\021\r\024\n )0.5(\027\026\031\004\027\t\b \023\031\002\035\017\022\026\006\017\005 )]TJ 0.049 Tw T* (\023\024)Tj /Span<>> BDC ( )Tj EMC (\021\036\n\036 \017\f\f\035\036\007\024\r\026\027\017\016, \022\026\022 \ \017)Tj /Span<>> BDC ( )Tj EMC (\007\024\023\031\f\021\017\n\024\f\021\034 \031\001\017\r\026\027\017\016\ )Tj 0.085 Tw T* (\024\007\017\027\024\004\027\t\b \030\026\027 \023\030\016\n\024\005 \022\ \017\001\022\017, \030\026\n\036\030\026\n\017 \007\024)Tj /Span<>> BDC ( )Tj EMC (2,0 \f\n. )Tj 0.143 Tw 0 -1.218 TD (\215\030\017)Tj /Span<>> BDC ( )Tj EMC 1.996 0 Td [(\n\027\024\032\036\f\021\r\036\027\027\t\b )0.6(\017)]TJ /Span<>> BDC ( )Tj EMC 7.816 0 Td [(\f\022\r\024\027\t\b )0.6(\030\026\027\036\027\017\016\b )0.5(\023\024\022\026\026\027\026 )]TJ 0.034 Tw -9.812 -1.218 Td (\024\002\f\021\030\031\022\021\017\r\027\026\016 \030\036\036\022\006\017\ \016 \023\024)Tj /Span<>> BDC ( )Tj EMC (\021\017\023\031 \024\023\036\030\026\006\017\017 \206\026\030\021\n\026\ \027\026. )Tj 0.067 Tw 0 -1.218 TD (\203\026)Tj /Span<>> BDC ( )Tj EMC (\220\021\026\023\036 \f\023\036\006\017\026\035\017\017\030\024\r\026\027\ \027\024\005 \n\036\007\017\006\017\027\f\022\024\005 \023\024\n\024\013\ \017 )Tj 0.061 Tw T* (\021\026\022\032\036 \023\030\017\n\036\027\017\n \023\030\036\007\f\021\ \026\r\035\036\027\027\t\005 \026\035\020\024\030\017\021\n, \f)Tj /Span<>> BDC ( )Tj EMC (\031\004\036\021\024\n )Tj 0.12 Tw T* (\017\n\036\033\013\036\005\f\016 \035\026\002\024\030\026\021\024\030\027\ \024-\007\017\026\020\027\024\f\021\017\004\036\f\022\024\005 \002\026\t\ , \023\024)Tj 0 Tw (-)Tj 0.265 Tw T* (\r\024\035\016\033\013\017\005 \r\t\023\024\035\027\017\021\034 \022\024\ \030\030\036\022\021\017\030\031\033\013\017\005 \024\002\255\201\n \b\017\ )Tj 0 Tw (-)Tj T* (\030\031\030\020\017\004\036\f\022\024\005 \023\024\n\024\013\017.)Tj 0.272 Tw T* (\221\026\022\017\n \024\002\030\026\024\n, \n\024\032\027\024 \026\022\ \035\033\004\017\021\034, \004\021\024 \f\024\004\036\021\026\027\027\t\005\ )Tj 0.21 Tw T* (\b\026\030\026\022\021\036\030 \024\021\n\036\004\036\027 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (89,3%, \r\024 2-\005 )Tj 0.014 Tw T* (\020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 \r)Tj /Span<>> BDC ( )Tj EMC (100%. \230\024\035\017\030\024\r\026\027\027\t\005 \b\026\030\026\022\021\ \036\030 \030\026\027\036\027\017\005 )Tj -0.084 Tw T* (\r\f\021\030\036\004\026\035\f\016 \r)Tj /Span<>> BDC ( )Tj EMC (10,7% \022\035\017\027\017\004\036\f\022\017\b \027\026\002\035\033\007\036\ \027\017\005 \023\030\017)Tj /Span<>> BDC ( )Tj EMC (\r\027\031)Tj 0 Tw (-)Tj 0.409 Tw T* (\021\030\017\002\030\033\001\017\027\027\t\b \030\026\027\036\027\017\016\ \b, \022\024\021\024\030\t\036 \023\030\036\r\026\035\017\030\024\r\026\035\ \017 )Tj 0.223 Tw T* (\017)Tj /Span<>> BDC ( )Tj EMC 0.973 0 Td [(\f\024\f\021\026\r\017\035\017 )0.6(68,8%. )0.5(\200\027\036\002\030\033\001\017\027\027\t\036 )0.6(\217\215\025 )0.5(\f\024\f\021\026\r\017\035\017 )]TJ 0.161 Tw -0.973 -1.218 Td [(31,2%. \210\006\036\027\022\026 \023\024\035\031\004\036\027\027\t\b )0.5(\030\036\031\035\034\021\026\021\024\r \023\024\022\026\t\r\026\036\021\ , )]TJ -0.043 Tw T* (\004\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\024\002\036\017\b \020\030\031\023\023\026\b \027\026\004\017\n\024 \023\ \030\036\r\026\035\017\030\024\r\026\035\017 \024\f\022\024\035\024\004)Tj 0 Tw (-)Tj 0.067 Tw T* (\027\t\036 \030\026\027\036\027\017\016. \221\026\022, \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036 \024\027\017 \f\024\f\021\026\r\017\035\017\ 79,6% )Tj -0.038 Tw T* (\f\035\031\004\026\036\r, \023\030\036\r\026\035\017\030\024\r\026\035\017\ \027\026\007 \023\031\035\036\r\t\n\017 \(16,1%\) \017)Tj /Span<>> BDC ( )Tj EMC (\n\017\027)Tj 0 Tw (-)Tj 0.044 Tw T* (\027\024-\r\030\t\r\027\t\n\017 \(4,3%\). \200\024 2-\005 \020\030\031\023\ \023\036 \021\026\022\032\036 \023\030\036\024\002\035\026)Tj 0 Tw (-)Tj 0.205 Tw T* (\007\026\035\017 \024\020\027\036\f\021\030\036\035\034\027\t\036 \024\f\ \022\024\035\024\004\027\t\036 \030\026\027\036\027\017\016)Tj /Span<>> BDC ( )Tj EMC (\227 71,5% )Tj -0.007 Tw T* (\f\035\031\004\026\036\r \023\030\024\021\017\r \023\031\035\036\r\t\b \(\ 4,7%\). \203\026\017\002\024\035\036\036 \004\026\f\021\024 \r)Tj /Span<>> BDC ( )Tj EMC (\f\024)Tj 0 Tw (-)Tj 0.094 Tw T* (\004\036\021\026\027\017\017 \f)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\036\n \r\027\031\021\030\017\002\030\033\001\017\ \027\027\024\020\024 \024\021\007\036\035\026 \023\030\016)Tj 0 Tw (-)Tj 0.061 Tw T* [(\n\024\005 )0.5(\022\017\001\022\017 )0.6(\024\021\n\036\004\036\027\024 )0.5(\023\024\r\030\036\032\007\036\027\017\036 )0.6(\n\024\004\036\r\024\020\024 )0.5(\023\031\t\030\016, )]TJ 0.076 Tw T* [(\023\030\024\f\021\026\021\t )0.5(\017)]TJ /Span<>> BDC ( )Tj EMC (\031\030\036\021\030\t)Tj /Span<>> BDC ( )Tj EMC [(\227 )0.5(32,2% \f\035\031\004\026\036\r, )0.5(\n\026\020\017\f\021\030\026\035\034\027\t\b )]TJ 0.176 Tw T* (\f\024\f\031\007\024\r)Tj /Span<>> BDC ( )Tj EMC (\227 28%, \022\024\f\021\036\005 \021\026\026)Tj /Span<>> BDC ( )Tj EMC (\227 25,8%. \230)Tj /Span<>> BDC ( )Tj EMC (\024\030\020\026\027\024\r )Tj 0.347 Tw T* (\002\030\033\001\027\024\005 \023\024\035\024\f\021\017 \027\026\017\002\ \024\035\036\036 \004\026\f\021\024 \026\235\017\022\f\017\030\024\r\026\ \027\024 )Tj 0.069 Tw T* (\030\026\027\036\027\017\036 \021\024\027\022\024\005 \022\017\001\022\017\ )Tj /Span<>> BDC ( )Tj EMC (\227 22,6% \f\035\031\004\026\036\r, \024\002\024\007\024\004\027\024\005\ )Tj 0.116 Tw T* (\022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 19,3% \027\026\002\035\033\007\036\027\017\005. \221\026\022\032\036\ \r)Tj /Span<>> BDC ( )Tj EMC (7,5% \f\035\031\004\026\036\r )Tj 0.07 Tw T* (\024\021\n\036\004\036\027\024 \023\024\r\030\036\032\007\036\027\017\036\ \032\036\035\031\007\022\026, \026)Tj /Span<>> BDC ( )Tj EMC (\r)Tj /Span<>> BDC ( )Tj EMC (3,2%)Tj /Span<>> BDC ( )Tj EMC (\227 \020\036\023\026\021\024)Tj 0 Tw (-)Tj 0.206 Tw T* (\002\017\035\017\026\030\027\024\005 \024\027\t. \215\030\017)Tj /Span<>> BDC ( )Tj EMC [(\r\027\036\002\030\033\001\017\027\027\024\005 )0.5(\035\024\022\026\035\017\026\006\017\017, )]TJ 0.355 Tw T* [(\027\026\017\002\024\035\036\036 \004\026\f\021\024 \r\f\021\030\036\004\ \026\035\017 )0.5(\023\024\r\030\036\032\007\036\027\017\016 \n\024\004\036\r\024\020\024 \ )]TJ 0.2 Tw T* (\023\031\t\030\016, \031\030\036\021\030\t)Tj /Span<>> BDC ( )Tj EMC (\227 30,9% \022\035\017\027\017\004\036\f\022\017\b \f\035\031\004\026\036\ \r, \022\024)Tj 0 Tw (-)Tj 0.014 Tw 0 -1.218 TD (\f\021\036\005 \021\026\026)Tj /Span<>> BDC ( )Tj EMC (\227 28,6%, \n\026\020\017\f\021\030\026\035\034\027\t\b \f\024\f\031\007\ \024\r)Tj /Span<>> BDC ( )Tj EMC (\227 23,8%. )Tj 0.152 Tw 0 -1.218 TD (\200)Tj /Span<>> BDC ( )Tj EMC (\n\036\027\034\001\036\005 \f\021\036\023\036\027\017 \017\n\036\035\017\ \n\036\f\021\024 \023\024\r\030\036\032\007\036\027\017\016 \024\002\024\ )Tj 0 Tw (-)Tj 0.198 Tw 0 -1.218 TD (\007\024\004\027\024\005 \022\017\001\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 4,3% \027\026\002\035\033\007\036\027\017\005 \017)Tj /Span<>> BDC ( )Tj EMC (\021\024\027\022\024\005 \022\017\001)Tj 0 Tw (-)Tj T* (\022\017)Tj /Span<>> BDC ( )Tj EMC (\227 9,5% \f\035\031\004\026\036\r.)Tj 0.05 Tw T* (\215\030\017 \026\027\026\035\017\036 \030\036\031\035\034\021\026\021\ \024\r \017\031\004\036\027\017\016 \024\002\255\201\n\026 \024\023\036\ \030\026\006\017\005 )Tj 0.283 Tw T* (\023\030\017)Tj /Span<>> BDC ( )Tj EMC (\030\026\027\036\027\017\016\b \023\030\016\n\024\005 \022\017\001\022\017\ \n\024\032\027\024 \024\021\n\036\021\017\021\034, \004\021\024 )Tj -0.016 Tw T* (\031\001\017\r\026\027\017\036 \030\026\027 \023\030\017\n\036\027\016\035\ \024\f\034 \023\030\017\n\036\030\027\024 \r)Tj /Span<>> BDC ( )Tj EMC (\030\026\r\027\024\n \022\024\035\017)Tj 0 Tw (-)Tj -0.03 Tw T* (\004\036\f\021\r\036 \(\r 1-\005 \020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 30,2%, \r\024 2-\005 \020\030\031\023\023\036)Tj /Span<>> BDC ( )Tj EMC (\227 28,5%, )Tj 0.081 Tw T* (\f\024\024\021\r\036\021\f\021\r\036\027\027\024\). \217\036\036\022\006\ \017\016 \023\030\016\n\024\005 \022\017\001\022\017 \002\t\035\026 \023\ \030\017)Tj 0 Tw (-)Tj 0.054 Tw T* (\n\036\027\036\027\026 \027\026)Tj /Span<>> BDC ( )Tj EMC (57,9% \004\026\013\036 \r)Tj /Span<>> BDC ( )Tj EMC (1-\005 \020\030\031\023\023\036 \(69,8%\) \023\024)Tj /Span<>> BDC ( )Tj EMC (\f\030\026\r)Tj 0 Tw (-)Tj -0.037 Tw T* (\027\036\027\017\033 \f\024 2-\005 \020\030\031\023\023\024\005 \(11,9%\)\ , \023\030\017)Tj /Span<>> BDC ( )Tj EMC /T1_2 1 Tf 0 Tw (p)Tj /T1_1 1 Tf -0.037 Tw /Span<>> BDC ( )Tj EMC (<)Tj /Span<>> BDC ( )Tj EMC (0,05,)Tj /T1_2 1 Tf 0 Tw ( )Tj /T1_1 1 Tf -0.037 Tw 17.825 0 Td (\004\021\024 \n\024\032\027\024 )Tj ET q /GS0 gs 221.1023475 0 0 112.3516816 42.5196833 389.1611042 cm /Im0 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 Tw 9 0 0 9 42.5197 378.3611 Tm (\022\t\217\210\b\002\220 2.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \f\020\240\031\032\020\023\031\032\025\013\ \200 \033\031\n\020\016\020\023\027\f\027\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 -1.2 TD [(F)-16(igure 2)16.1(.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Dynamics of)Tj /Span<>> BDC ( )Tj EMC [(laborator)-42.8(y parameters)]TJ ET q /GS0 gs 221.1023475 0 0 109.7109404 42.5196833 247.3462378 cm /Im1 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 236.5462 Tm (\022\t\217\210\b\002\220 3.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \220\022\025\020\026\022\n\020 \205-\032\027\020\n\023\022\021\025\031\b\ \031 \240\027\f\n\020)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 3.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( Dynamics of)Tj /Span<>> BDC ( )Tj EMC [(C-reactiv)13.2(e p)46(ro)13(tein)]TJ ET q /GS0 gs 221.1023475 0 0 114.2722228 42.5196833 100.9700975 cm /Im2 Do Q BT 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 9 0 0 9 42.5197 90.1701 Tm (\022\t\217\210\b\002\220 4.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \206\027\016\r\f\017\023\020\023\013 \031\006\027\025\n\022 \033\031)Tj /Span<>> BDC ( )Tj EMC (\211\003\237 \240\031\f\022)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf T* [(F)-16(igure 4.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf [( R)21(esults of)]TJ /Span<>> BDC ( )Tj EMC [(the visual analog scale assess)33.3(ment of)]TJ /Span<>> BDC ( )Tj EMC (pain)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf 0 72.346 TD (\020\004\206\f\t\204\004 7.)Tj 0 0 0 1 k /GS1 gs /T1_2 1 Tf ( \225\020\032\020\n\023\027\032\022\024\023\022\n\020 \031\024\f\031\255\ \025\027\025\022\235)Tj 1 0.68 0 0.12 k /GS0 gs /T1_3 1 Tf -0.076 Tc 0.076 Tw 0 -1.2 TD [(T)-48.5(a)-84.3(b)-89.8(l)-87.7(e)-76( 7.)]TJ 0 0 0 1 k /GS1 gs /T1_2 1 Tf 0 Tc 0 Tw 3.25 0 Td [( C)-1.1(ha)-4.2(r)3.3(a)-9.1(c)-32.4(t)-1.6(e)-6(r)-39(i)6.6(s)-14.8(t)-29.1(i)-1.8(c)-26.7(s o)4.1(f)]TJ /Span<>> BDC ( )Tj EMC [(c)2.8(o)-4(m)-1(p)-4.9(li)-1.8(c)3.2(a)-9.2(t)-29.1(i)-1.4(o)-4(n)3.7(s)]TJ ET 0 0 0 1 K 0.5 w /GS2 gs q 1 0 0 1 42.5197 715.181 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 235.5256 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 337.5728 715.181 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 439.6201 715.181 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 496.313 703.9617 cm 0 0 m 0 10.969 l S Q q 1 0 0 1 42.5197 703.7117 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 703.7117 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 703.7117 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 703.7117 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 692.5005 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 692.2505 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 692.2505 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 692.2505 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 692.2505 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 681.0392 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 680.7892 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 680.7892 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 680.7892 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 680.7892 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 669.5779 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 669.3279 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 669.3279 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 669.3279 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 669.3279 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 658.1166 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 657.8666 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 42.7697 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 235.5256 657.8666 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 235.5256 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 337.5728 657.8666 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 439.6201 657.8666 cm 0 0 m 56.943 0 l S Q q 1 0 0 1 439.6201 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 496.313 646.6553 cm 0 0 m 0 10.961 l S Q q 1 0 0 1 42.5197 646.4053 cm 0 0 m 193.006 0 l S Q q 1 0 0 1 235.5256 646.4053 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 337.5728 646.4053 cm 0 0 m 102.047 0 l S Q q 1 0 0 1 439.6201 646.4053 cm 0 0 m 56.943 0 l S Q BT /GS1 gs /T1_3 1 Tf 8 0 0 8 117.3998 706.5463 Tm (\017\217\f\002\202\b\r\b\t\r)Tj 17.188 0 Td (\017\217\b\002\b\004\235 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (15\))Tj 12.489 0 Td (\255\006\004\b\r\b\t\235 \()Tj /T1_4 1 Tf (n)Tj /T1_3 1 Tf /Span<>> BDC ( )Tj EMC (=)Tj /Span<>> BDC ( )Tj EMC (24\))Tj /T1_4 1 Tf 13.884 0.001 Td (p)Tj /T1_1 1 Tf -52.536 -1.433 Td (\200\027\031\021\030\017\002\030\033\001\027\024\005 \026\002\f\006\036\f\ \f)Tj 29.146 0 Td (6,6%)Tj 12.506 0 Td (12,6%)Tj 10.301 0 Td (0,56)Tj -51.953 -1.433 Td (\210\f\021\030\026\016 \022\017\001\036\004\027\026\016 \007\017\027\026\ \n\017\004\036\f\022\026\016 \027\036\023\030\024\b\024\007\017\n\024\f\021\ \034)Tj 28.896 0 Td (13,4%)Tj 13.006 0 Td (4,2%)Tj 10.051 0 Td (0,74)Tj -51.953 -1.433 Td (\206\027\024\005\027\t\036 \026\002\f\006\036\f\f\t \017)Tj /Span<>> BDC ( )Tj EMC (\235\035\036\020\n\024\027\t \021\026\026)Tj 29.489 0 Td (0%)Tj 12.163 0 Td (33,3%)Tj 10.051 0 Td (0,001)Tj -51.703 -1.433 Td (\202\027\026\220\030\024\002\027\026\016 \027\036\022\035\024\f\021\030\017\ \007\017\026\035\034\027\026\016 \017\027\235\036\022\006\017\016)Tj 29.146 0 Td (6,6%)Tj 13.135 0 Td (8,3)Tj 9.671 0 Td (0,76)Tj -51.953 -1.433 Td (\210\020\027\036\f\021\030\036\035\034\027\t\005 \023\036\030\017\021\024\ \027\017\021*)Tj 28.896 0 Td (73,4%)Tj 13.135 0 Td (41,6)Tj 9.921 0 Td (0,62)Tj 1 0.68 0 0.12 k /GS0 gs /T1_0 1 Tf 7.5 0 0 7.5 42.5197 759.8869 Tm [(\036\033\030\031\030\007\f)-20.9(\035\214\007\231\240 \001\032)50(\f)42(\032\214\030)]TJ 51.938 0 Td (ORIGINAL ARTICLES)Tj /T1_5 1 Tf 25 0 0 25 512.002 56.0378 Tm (61)Tj ET endstream endobj 1319 0 obj <>stream Adobed     '$''''$25552;;;;;;;;;;   ####''',,,   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